LOCUS 042_IIG_Bs27_027_SNP 3500474 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1ev-cvskbtq VERSION urn.local...1ev-cvskbtq KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3500364..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 226633..226634 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_026" CDS 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /modified_by="User" /translation="MQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIAS GPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADF AEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDV YKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYV FTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPE YVNQRVLSFLCGGIK*" /label="PG10_pseudo_BSU02260" gene 226647..227522 /gene="cesB" /locus_tag="PG10_pseudo_BSU02260" /old_locus_tag="BSU_02260" /modified_by="User" /label="PG10_pseudo_BSU02260" promotor_-35 226866..226873 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 226882 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 226887..226905 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 227523..227717 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 227718..228251 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 228242..228730 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 228723..229514 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 229489 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 229569..229847 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 229890..229899 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 229908 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 229912..229927 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 229953..231293 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 231293 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 231359 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 231362..231381 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 231401..232288 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 232289..232432 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 232404..232411 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 232425..232444 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 232434 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 232488..233456 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(233310..233328) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(233327) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(233344..233349) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 233453 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(233492) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(233492..234736) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(234770..234788) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234779) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234799..234807) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(234807..234825) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234823) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234841..234846) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(234881..236776) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(234897) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 236642..236661 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 236659 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(236797..237546) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 237519..237700 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(237547..237617) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(237606..237625) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(237621) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(237641..237648) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 237687..237694 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 237702 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 237707..237726 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 237765..238472 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 238438..238439 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238455..238469 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238465 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 238506..238781 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(238564..238582) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(238570) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(238597..238603) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 238773 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 238824..238828 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 238844..238863 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 238850 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 238861..238989 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 238990..240060 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 240049 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(240097..241509) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(240114) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(241510..241621) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(241594..241613) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(241621) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(241628..241635) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(241630..242577) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(242615..242634) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(242632) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(242649..242656) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(242706..244142) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(242721) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(244165..245148) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(245242..245259) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 245247..245266 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(245249) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 245253 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(245275..245282) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 245450..246682 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 246693..247637 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 247614 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 247734..247741 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 247746..247863 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 247746 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 247755..247774 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 247864..248790 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 248820..250286 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 250370..251737 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 251774..253141 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 253155..253162 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 253177..253194 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 253180 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 253211..253912 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 253862 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 253906 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 254003..255535 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 255547..255550 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 255565..255584 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 255577..255811 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 255577 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 255812..256732 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 256734..256741 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 256756..256775 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 256766 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 256789..257036 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 257005 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 257134..257295 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 257212..257312 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 257272 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 257316..258254 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 257360 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 258277..258296 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 258282..258350 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 258282 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 258351..259031 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 259033..259968 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 260060..260983 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(260530..261714) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 261002..261688 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(261649..261783) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 261683 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(261743..262129) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(261759) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(262155..262173) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262174) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(262187..262193) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(262207..263205) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(262250) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 262386..262391 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 262405 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 262407..262425 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(262419) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(262421..262435) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(262441) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(262443..262447) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 262443..262871 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 262850 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 262916..262922 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 262935..262954 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 262937 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 262977..263708 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(263179..263198) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263205) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263212..263219) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 263626 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 263790..263966 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 263918..263924 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 263931..263948 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 263942 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 263985..265736 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(264039..264054) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264045) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264067..264076) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 265749..265961 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 265962..266021 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 266022..266750 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(266030) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(266747..267394) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(267409..267428) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 267422..267428 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(267423) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(267443..267447) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 267443..267462 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 267445 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 267473..268585 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(267819) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(267822..267841) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(267857..267861) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 268579 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(268627..270066) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(268634) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(270106..270672) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(270710..270729) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(270724) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(270744..270751) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 270826..270832 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 270848..270865 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 270854 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 270889..272016 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 271989 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 272113..272119 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272133..272152 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272133 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 272179..272817 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 272803 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 272848..273438 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(272855..273238) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(272879) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(273052,273054) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(273268..273287) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(273275) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(273301..273308) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 273410..273413 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273429..273448 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273440 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 273473..274549 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 274543 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(274589..275545) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(274617) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(275558..276259) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(276283..276302) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(276289) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(276318..276321) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 276339..276342 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 276358..276377 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 276368 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 276403..277143 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 277144..278304 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 278355..278363 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 278375..278393 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 278375 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 278440..279372 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(279412..280476) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(279413) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(280477..280667) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(280499..280630) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(280652..280671) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(280672) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(280686..280693) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 280804..282222 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(282265..282283) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282273) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282297..282304) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 282329..282408 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 282329 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 282331..282337 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 282352..282369 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 282409..283770 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 283771..284351 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(283778..284281) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(284282..284363) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 284353 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(284355..284374) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 284356..284375 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(284364) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 284404..285525 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 285519 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 285566..285572 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 285587..285605 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 285590 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 285632..286408 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(285639) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 286433..288118 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 287373..287473 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 287433 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 287499 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 288115 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 288209..288216 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288232..288251 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288238 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 288306..289265 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 288861..288867 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 288881..288900 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 288885 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 289237 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 289321..290016 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 289974..290816 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 290803 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(290854..291849) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 291805..291812 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 291827..291846 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 291833..292035 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 291833 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(291881..291900) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(291889) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(291915..291922) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 292019..292028 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 292037..292132 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 292037 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 292041..292056 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 292133..292732 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 292754..293335 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 293370..293948 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 293999..294772 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 294759 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 294857..296470 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 296486..297577 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 297551 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 297631..297638 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 297653..297672 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 297661 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 297699..298901 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 298881 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(299154..300326) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(299169) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(300395..300697) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(300423) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(300680..300699) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(300699) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(300713..300719) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 300946..300965 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 300946 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 300987..302243 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(300995) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 302245..303093 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 303093..303974 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 303955 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(303987) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(304012..305163) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(304031) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(305164..305251) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 305219..305226 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(305238..305257) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 305241..305260 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(305251) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 305254 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(305270..305276) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 305313..306746 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 306051..306059 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306071..306089 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306090 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 306728 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 306789..306796 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 306811..306830 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 306820 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 306862..307443 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 307256 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 307260..307264 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 307419..307426 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307441..307460 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 307454..307591 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 307454 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 307592..309571 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 309585 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 309651..309658 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 309668 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 309672..309691 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 309748..310713 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 310745..312370 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 310751 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 312357 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(312415..313953) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(312433) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(313007..313107) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(313047) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 313967..313971 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 313987..314006 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314001 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(314033..314052) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(314036) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 314066..314530 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(314067..314073) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 314540..314545 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 314561..314579 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 314571 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 314604..315233 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 315244..315253 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315267..315286 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315275 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 315303..316064 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(315703..316065) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 316061 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(316066..317406) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(317433..317444) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(317443) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(317459..317465) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 317485..317491 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 317499 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 317506..317517 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 317536..318132 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 318140..318147 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 318161..318261 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 318161..318180 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 318161 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(318257) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 318262..319080 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 319062 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(319130..319723) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(319137) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(319738..319757) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319753) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319772..319775) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(319781..319929) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 319831..319838 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 319851..319870 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 319853..319961 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 319855 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(319923..319941) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 319929..319936 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(319939) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319951..319970 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(319957..319962) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319963 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 319999..320559 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 320536 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(320587..321348) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(320611) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(321380..321399) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321381..321388 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321386) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321403..321422 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321414..321419) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321415 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 321466..322440 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 322441..322511 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 322512..323468 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 322927..322933 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 322948..322959 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 322955 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 323469..323547 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 323522..323527 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 323544..323562 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 323549 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 323552..324334 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 324299 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 324344..324471 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 324448..324452 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324467..324486 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324473 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 324525..325436 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 325453..327000 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 326424..326430 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326444..326463 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326452 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 326535..326541 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326554..326573 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326563 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 326999..327003 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 327001..327123 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 327003 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 327124..328545 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(327644..329499) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 328525 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 328570..328666 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 328637..328644 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328659..328678 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328668 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 328698..329933 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(329492..329510) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(329509) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(329524..329531) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(329917) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(329970..330827) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(329983) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(330832..331716) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(331768) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(331773..331786) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(331801..331809) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(331816..332670) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(332689..332708) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(332709) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(332723..332726) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 332760..332779 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(332760..332778) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 332767..332831 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 332768 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(332777) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(332794..332799) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 332832..333842 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 333843..336290 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(333874..335325) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(333878) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(335386..335706) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 335557..335562 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 335576..335580 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 335583 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(335615) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(335617..335636) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(335650..335657) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(335738..338155) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(338180..338199) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(338194) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(338211..338217) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(338277..340409) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(340416..342731) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(342750..342850) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(342790) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 342833..342840 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 342854..342873 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 342866 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 342911..344116 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 344101 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 344160..344166 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 344181..344200 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 344189 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 344233..345147 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 345144..345728 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 345739..345746 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 345760..345779 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 345770 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 345824..346009 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 346037..347230 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 347222 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 347267..348936 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(347279..347959) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(347285) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(347969..348832) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(348854..348873) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(348866) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(348868..351702) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(348888..348895) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 348905..348911 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 348926..348944 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 348938..349160 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 348938 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 348994..349191 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 349129..349134 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 349150..349168 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 349162 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 349210..349665 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 349640 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 349688..349694 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 349701 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 349708..349719 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 349747..350079 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 350060 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 350165..350172 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350188..350207 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350192 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 350233..351666 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 351644 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(351703..352101) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(352098..352198) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(352128..352577) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(352138) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(352592..352611) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(352600) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(352602..352744) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(352625..352632) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(352745..354466) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 352757..352764 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 352775..355918 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 352775 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 352779..352798 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(352780..352880) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(352820) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(354490..354508) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(354505) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(354522..354529) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(354577..355134) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(354580) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(355140..355772) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(355798..355817) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(355813) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(355832..355835) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 355896..355899 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 355914..355933 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 355920 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 356006..356368 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 356352 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 356615..356618 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 356633..356652 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 356641..356941 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 356641 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 356942..367705 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 367718..378469 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 370854..370994 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 378506..382333 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 382362..383090 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 383072 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 383128..383135 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 383138 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 383147..383166 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 383191..384417 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 384411 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(384432..384989) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(384447..384547) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(384469) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(384487) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(385018..385037) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(385020) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(385043..385981) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(386020..386038) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(386027) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(386054..386059) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 386105..387439 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(387434..387601) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(387612..388109) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(388136..388155) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(388148) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(388214..388861) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(388890..388909) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(388893) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(388925..388929) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(389030..389181) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(389182..389925) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(389238) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(389939..390643) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(390630..391436) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(391485..391504) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(391497) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(391518..391525) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(391552..392424) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(392162..392180) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392169) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(392195..392201) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 392478..392485 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(392493..392512) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 392499..392518 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(392499) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 392507 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 392514..393128 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(392526..392533) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 393131..394552 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 394569..394796 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 394793..395257 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 395238 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 395264..395265 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 395265 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 395324..396169 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(396209..397687) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(396217) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 397714..397716 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(397715..397734) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 397725 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 397733..397751 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(397735) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(397737..>397920) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(397749..397756) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 397905..397914 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 397920..397921 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 397926 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(397936..399375) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(398260..398271) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(398266) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(398285..398291) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399418..399437) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 399419..399426 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(399425) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399440..399459 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399444 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399448..399455) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 399482..400792 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 400670..400676 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400690..400708 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400698 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 400794..400801 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 400816..400835 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 400825 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 400861..402249 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 402257 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 402307..402313 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402327..402338 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402328 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 402372..403235 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 403255..404040 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 403360..403379 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 403360 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 403448 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 404042 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(404085..404699) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(404096) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(404712..406337) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(406372..406944) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(406966..406985) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(406981) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(406999..407006) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 407066..407085 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 407078 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 407109..407462 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 407433 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 407526..407533 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 407547..407566 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 407552 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 407562..407634 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 407635..409071 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 409096..409527 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 409529..410650 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 410633 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 410679..410682 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 410698..410717 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 410700 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 410741..411805 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 410975..410983 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 410997..411016 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411007 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 411799 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 411872..411879 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411892..411911 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411905 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 411940..412503 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 412504..413228 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(412563..413171) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(413189..413208) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 413205..413211 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(413212) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 413224..413243 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413230 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 413257..413649 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 413626 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(413682..413846) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(413702) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(413856..413874) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413878) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413889..413895) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413908..413915 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413929..413948 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413932 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 413979..414728 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 414705 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(414781) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 414811..414817 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 414831..414850 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 414837..414933 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 414837 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 414934..415707 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 415722..416936 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 416960..417733 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 417778..418500 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 418503..419510 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 418996 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 419090..419190 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 419150 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 419526..420278 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 420276..420285 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 420299..420318 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 420309 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 420342..420983 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 420969 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(420981..421406) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(421026) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 421059..421065 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421079..421098 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421080 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 421156..421401 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 421402..421812 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(421407..421694) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(421715..421734) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(421731) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 421788..421792 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421809..421828 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421814 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 421845..423851 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 423852..423952 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 423953..424855 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 424835 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 424928..424935 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424949..424968 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 424953..425040 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 424953 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 425041..427125 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 427112 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 427154..427160 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427174..427192 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427186 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 427197..427278 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 427240..427247 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 427261..427280 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 427280 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 427337..428848 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 428832 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(428868..429413) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(428901) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(429480..429498) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(429494) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(429513..429519) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 429555..429561 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 429573 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 429576..429594 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 429620..430480 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 430496..430999 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 430980 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 431028..431035 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431049..431068 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431051 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 431085..431636 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 431651..431657 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431672..431690 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431685 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 431714..432136 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 432141..432149 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432160..432179 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 432179..432545 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 432179 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(432205..432305) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(432240..432508) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(432245) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 432502 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 432582..432591 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432604..432619 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432609 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 432642..433451 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 433432 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(433495..433785) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(433499) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(433813..433832) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 433813..433831 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 433819 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(433829) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 433907..433914 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433928..433947 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433932 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 433970..434404 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 434401..434404 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 434413 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 434421..434440 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 434469..436652 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 436635 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 436701..436707 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 436722..436740 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 436723..436854 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 436723 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 436855..437943 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 437924..438775 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 438786..440495 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 440488..441750 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 441756..443867 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 443851 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 443964..443971 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443986..444005 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443993 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 444003..444146 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 444144 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 444189..444342 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 444343..446166 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 446158 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 446225..446674 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 446687..446693 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 446708..446726 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 446709 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 446741..448465 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(447577..448436) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(448438..448549) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 448449 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(448457..448660) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(448481) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(448509..448609) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 448518..448523 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448540..448558 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448549) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 448550..448765 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 448550 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(448616..448687) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(448659) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(448688..448954) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(448970..448989) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(448988) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(449001..449008) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(449058..450335) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(449077) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(450397..450416) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450409) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450411..450488) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(450429..450436) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(450472..450491) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450488) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450505..450514) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(450565..450822) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(450573) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(450639) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(450900..451352) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(451371..451389) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(451388) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(451403..451409) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 451421 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 451429..451448 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 451470..452288 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 452279 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 452356..452362 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452376..452394 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452384 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 452417..452788 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(452421) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 452805 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(452839) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(452842..452845) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 452867..452874 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 452886..452905 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 452893 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 452920..453261 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 453255..453614 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(453317..453610) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 453555 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 453599 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(453651..454472) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(453655) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(454494..454512) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(454515) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(454526..454532) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(454557..455609) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 454869..454876 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 454891..455678 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 454891..454910 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454892 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(455622..455641) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(455627) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(455655..455662) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 455679..457286 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 457276..457956 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 457957..458031 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 457998..458005 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 458020..458037 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 458033 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 458077..459342 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 459335 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(459389) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 459426..459443 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 459428 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 459490..460542 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 460543..460786 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 460743 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 460819..461745 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 461765..462505 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 462564..462583 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 462569 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 462600..462935 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 462910 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 462955..463024 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 462990..462997 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 463011..463030 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 463025 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 463063..464208 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 464190 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(464233..464412) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(464251) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(464366..464530) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(464413..464581) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(464573..464592) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(464583) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(464607..464614) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 464722..464727 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464743..464761 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464747 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 464777..465649 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 465013..465022 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465035..465050 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 465038 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(465594..465663) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(465637) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 465650..465999 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(465664..465984) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 465980..465984 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 465993..466007 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 466001..466158 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 466001 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(466005..466024) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466020) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466038..466045) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 466159..467223 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 467211 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 467295..468668 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 468699..468705 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468719..468730 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 468729 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 468772..468791 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 468773..468947 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 468773 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 468915..468922 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 468937..468956 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 468949..469016 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 468949 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 469068..470552 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 470545 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 470665..470724 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 470665..470674 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 470667 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 470686..470701 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 470725..471204 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 471194..472675 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 472645 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 472690..473017 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(472699) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(472927..473526) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 472987..472992 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 473005..473024 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 473019..473620 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 473019 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(473550..473569) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(473561) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 473621..473986 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 473989..473994 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 474010..474151 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 474010..474028 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 474010 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 474152..475168 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 475153 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 475213..475220 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 475234..475253 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 475241 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 475283..476452 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 476381..476386 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476401..476419 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476407 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 476482..476485 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476501..476520 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476502 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 476568..476849 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 476854..477204 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(476994..477470) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(477037) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 477184 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 477238..477245 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477259..477278 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 477267 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 477319..478143 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(477453..477471) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(477470) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(477472..478071) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(477485..477492) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(478060..478078) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478071) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(478073..478661) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(478092..478098) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 478148..478513 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 478517..478918 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(478659..478678) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478676) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478692..478701) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 478930..479937 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 479931..479937 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 479952..479970 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 479958 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 479999..480328 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 480325..480807 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 480773..481561 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 481561..482160 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 482146 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 482204..482210 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482225..482244 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(482233,482235) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 482237 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 482271..482387 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 482403..482696 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 482664..482672 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 482684..482703 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 482693..483133 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 482699 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(482932..485987) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 483117..483560 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 483535 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 483591..483592 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 483608..483627 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 483608 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 483654..485813 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 485801..485820 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 485823..486039 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 485823 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(485823..485936) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(485976..485995) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(485993) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(486010..486018) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 486040..486492 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 486498..486504 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486519..486538 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 486527..486614 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 486527 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(486559) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 486615..486689 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 486694..486784 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 486814..486885 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 486897..486971 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 486998..487073 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 487085..487166 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 487231 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 487247..>487332 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 487332..487333 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<487333..487639) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 487352 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(487384) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(487640..488659) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(488335..488354) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488348) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488369..488376) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488448..488452 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488469..488488 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488473 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 488474..488918 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 488919..489329 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 489330..489399 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 489356 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(489452..489901) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 490016..490558 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 491031..491035 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 491052..491071 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 491061 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 491111..491875 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 492069..493379 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 493402..493961 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 493962..494138 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 494163..494849 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 495191..495195 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 495210..495229 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 495218 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(495265,495267) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 495274..495459 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 495458 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 495809..496402 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 496515..496522 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496536..496555 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496547..496664 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 496547 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(496582) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 496665..496865 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(496763..497551) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 496768 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 496869 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(496933..497011) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(497552..498013) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 498022..498567 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(498065) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(498072..498091) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(498107..498114) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 498534 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(498581..498817) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(498915..499790) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 499903..500862 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(499924) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(499928..499947) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(501015..501887) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(501980..501985) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(501987..501988) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(501992) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 502061..502067 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 502075 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 502081..502100 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 502114..503502 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 503478 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 503612..504904 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 504913..504919 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 504934..504953 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 504941 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 504952..505062 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 505063..505509 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 505538 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 505589..505596 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505611..505630 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 505612 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 505746..506339 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 506382 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(506458) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 506471..506478 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 506492 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 506493..506512 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(506691..507350) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(507399..507418) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(507406) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(507430..507435) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(507772..508635) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 508678..508684 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 508699..508718 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(508700..508719) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 508714 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(508724) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(508734..508741) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 508790..510181 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 510309..510316 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 510327..510346 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 510341 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 510375..510800 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 510801..512055 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(510853..511425) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(510858) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(511426..511506) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(511507..511836) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(511853..511872) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(511870) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 512044..512063 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 512057 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 512091..512963 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 512850 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 513048 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(513113..513499) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(513125) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(513500..513564) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 513552..513559 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(513553..513572) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(513566) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 513573..513592 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 513576 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(513587..513594) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 513610..514203 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(514347..515534) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 515670..515674 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 515688 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515689..515708 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 515738..516334 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 516448..516633 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 516612 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 516745..516748 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 516755..516941 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 516755 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 516763..516782 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 516942..517277 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 517290..518597 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 518629..518733 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 518742..518855 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 519041..519049 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 519060..519078 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 519077 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 519095..519880 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 519142 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 519890 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(519937..520857) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 520990..522438 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(522556..523179) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(523203..523222) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 523211..523218 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(523222) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 523233..523252 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 523235 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(523237..523243) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 523269..523949 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 523982 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(524029..524472) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(524034) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(524495..524514) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(524519) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524528..524535) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(524558..524737) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(524734..524877) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 524828..524830 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 524846..524865 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524862 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 525145..526368 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 526361..527002 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 526996 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(527029..527048) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(527050) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(527062..527069) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 527110..527115 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 527118..529292 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 527128 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 527130..527148 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(528194..528212) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(528194) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(529296..529703) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 529313..529317 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 529327 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 529330..529349 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(529341) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(529704..530606) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(530607..530702) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(530682..530701) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(530702) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(530715..530722) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(530808..531497) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(531587..532399) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(532428..532447) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532441) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532463..532470) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(532510..533403) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(532530) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(533404..533496) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(533477..533496) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(533494) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(533512..533519) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 533685..533692 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 533707..533726 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 533713 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 533879..534499 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 534223..534229 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 534234 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 534243..534261 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 534515..535453 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 535441..535444 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535459..535478 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 535466..535554 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 535466 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 535555..535944 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 535935 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 536058..536077 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 536060..536129 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 536060 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 536130..536468 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 536456 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(536508..536744) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(536532) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 536556..536562 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 536577..536588 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 536588 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(536745..536906) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(536910..537275) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(536950) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(537276..537506) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 537490 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(537527..537546) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537544) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(537546..537629) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(537560..537569) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(537630..538307) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(538278..538289) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(538292) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(538304..538310) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(538308..539141) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 538323..538328 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538343..538354 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538348 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 538420..539127 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(539142..539573) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(539586..539828) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(539842..540114) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(540136..540155) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(540140) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(540169..540178) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 540333..540340 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 540356..540375 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 540364 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 540413..541000 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 540997..541341 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 541342..541503 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 541504..541977 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 541978..542670 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(542120) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(542137..543780) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(543815..544012) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 543829..543831 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 543848..543866 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 543852 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(543858) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 543978 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(544004..544023) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(544016) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(544036..544043) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(544099) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(544100..545476) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(545526..545545) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(545541) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(545615,545617) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 545616..545649 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(545648..546166) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(545662) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(546192..546211) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546211) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546227..546230) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546248..546255 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546270..546289 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546288 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(546300..546701) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(546300..546428) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 546318..546410 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 546320..546321 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(546632..546826) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(546859..546870) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(546867) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546884..546890) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 546945..546952 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 546966..546985 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 546968..547068 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 546970 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(547016) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 547028 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 547036..547043 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547057..547076 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 547072..547159 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 547072 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 547160..547236 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 547250..547323 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 547483..549037 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 549205..552132 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 552188..552304 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 552318..552394 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 552455..552531 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 552528 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 552632..552636 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 552652..552671 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 552656 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 552712..553689 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 553704..554180 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 554161..554850 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 554860..555315 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 555308..556348 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 556312 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(556578..558506) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(556595) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 558258..558277 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 558268 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 558270..558459 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 558424..558431 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 558445..558464 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 558461..558631 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 558461 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(558526..558545) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(558538) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(558559..558566) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 558632..559144 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 559141..559788 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 559618..559718 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 559678 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 559810..559983 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 559990..560754 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 560734 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(560792..560983) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(560809) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(560980..561714) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 561372..561377 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561392..561410 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 561394 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 561713..561714 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 561724..561738 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 561746 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(561751..561770) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561768..561876 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(561771) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561784..561789) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 561850..561856 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561870..561889 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 561878..561952 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 561878 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 561953..562237 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 562284..563918 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 563919..564011 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 563968 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(564006..564134) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 564013..>565239 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(564137..564295) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(564340..564468) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(564561..564770) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(564763..565068) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(565239,565246) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 565240..565245 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(565344..567833) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(565366) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567847..567866) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567873) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567880..567887) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 567936..567937 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 567952..568034 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 567952 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 567953..567972 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 568035..569096 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 569170..570561 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 570588..570595 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 570609..570628 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 570614 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 570656..571618 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 571603 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 571743..571752 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 571759 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 571765..571780 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 571814..572497 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 572498..572562 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 572563..573588 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 573588..574352 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 574383..575354 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 575344 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 575388 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(575401..576426) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(576458..576477) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576476) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576491..576497) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576686..576693 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 576706 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 576708..577010 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 576708..576727 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 577011..578432 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 578424 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(578480) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(578480..579520) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 579060..579069 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579083..579102 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 579084..579619 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 579084 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(579521..579815) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 579620..579639 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 579621..579918 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 579621 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(579810..579824) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(579815) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 579917..579936 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579920 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 579959..580330 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 580316 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 580396..581442 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 581416 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(581476..581634) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(581492) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(581691..581823) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(581734) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(581824..582033) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(582066..582085) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582077) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(582116..582931) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 582758..582767 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582780..582799 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 582780 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(582944..583933) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(583798..583816) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583806) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583832..583837) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(583955..583970) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583976) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(583982..583991) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(584031..585572) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(584044) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(585603..585622) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(585617) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(585636..585645) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(585724..587133) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(585738) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(587171..587458) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(587174..587193) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(587188) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 587464..587471 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587487..587506 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587488 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 587531..588403 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 588368 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(588643) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 588697..588716 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 588707 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 588753..589715 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 589715..590911 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 590933..593146 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 593141..593148 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 593163..593182 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 593179..593308 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 593179 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 593309..594850 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 594836 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 594957..594961 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 594977..594996 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 594987 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 594994..595096 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 595122 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 595231..596553 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 596531 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 596574 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 596603..596612 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 596623..596763 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 596623 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 596625..596640 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 596764..597567 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 597552 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 597635..597642 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597656..597675 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597662..597725 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 597662 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 597726..597893 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 597900 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 597944..597950 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 597965..597983 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 597968..598054 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 597968 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 598033..598040 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598054..598073 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598056 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 598107..598661 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 598661..598858 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 598848 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 598904..598911 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 598926..598945 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 598928 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 598938..599040 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 599041..599180 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 599181..599669 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 599662..600804 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 600801..602096 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(601106..601125) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(601127) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(601140..601147) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 602170..602895 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 602888..603142 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 603139..603822 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 603806..606034 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(604054) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 606010..607440 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 607441..607541 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 607542..608582 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 608579..609166 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 608589..608603 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 608598 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(608865..608883) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(608872) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(608899..608904) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 609163..610701 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 610717..611985 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 611970 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(612025..612444) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(612514..612533) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(612523) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 612588..613862 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 613811 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(613877..614104) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(613888) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(614105..614525) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 614172..614177 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 614188 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 614191..614210 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 614233..615975 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(614510..614521) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(614525) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(614535..614541) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 614556 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 615949..615955 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615967 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615968..615987 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 616002..616997 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 617000..617314 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 617177 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 617319 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(617349..618926) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(617363) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(618940..618959) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(618959) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(618974..618980) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 619123..619126 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 619140 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 619143..619162 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 619191..619877 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 619939..622158 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 622182..624188 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 624204..625394 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(624399..624403) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(624403) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 625431..625450 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 625439..625555 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 625439 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(625503) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 625556..626566 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(625573..625673) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(625613) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 626549 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 626593..627397 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(626604..627302) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(626625) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(627322..627340) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(627343) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(627356..627361) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(627409..628887) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(627423) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(628275) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(628278..628291) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(628888..629018) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(629009..629027) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(629018) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(629042..629048) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 629149..629152 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 629167..629300 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 629167 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 629169..629188 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 629301..629591 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 629607..631064 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 631078..632508 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 632489 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(632523..633392) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(632565) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 633182..633187 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 633203..633221 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 633215 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(633393..633467) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 633445..633452 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(633461..633480) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 633467 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 633468..633487 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(633474) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(633495..633502) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 633524..636682 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 636669 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 636921..636924 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636939..636958 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636947 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 637005..637916 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 637917..638171 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 638172..639551 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 639552..640144 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(639564..640466) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 640101 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 640146..640446 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 640447..640782 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 640783..640856 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 640857..643496 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 643508..645307 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(643748..643763) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(643763) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(643775..643784) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645308..645419 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 645420..646568 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 646569..647758 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(646830..647135) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(647202..647408) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(647648..648103) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(647661) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(648123..650132) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(648490..648509) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(648497) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(648522..648527) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(650159..650178) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(650169) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 650344..651366 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 651466..651473 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 651487..651506 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 651488 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 651528..652658 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 652648..652821 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 652776 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 652822..652926 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 652893..652900 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 652915..652934 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 652928 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 652981..653700 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(652983) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 653558..653565 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653579..653598 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653589 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 653682 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 653769..653778 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 653792..653811 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 653795 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(653799..653817) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(653819) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(653833..653838) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 653834..654271 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(653841) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 654271 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 654331..654338 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654354..654373 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654359 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 654386..654970 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 654951 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 655049..655492 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 655489..656349 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 656411..656416 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 656432..656450 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 656432 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(656454..656468) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(656459) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(656476..656480) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 656476..656724 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 656708..656971 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 656986..657555 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 657556..657634 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 657607..657612 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 657627..657646 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 657636 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 657680..658222 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 658189 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 658245..658547 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 658590..658598 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658609..658627 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658615 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 658662..659291 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 659288..661021 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 661021..662127 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 662081 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 662166..662169 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 662184..662203 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 662191 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 662231..663514 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 663511..664440 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 664444..665334 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 665350..666384 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 666407..668692 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 668706..669404 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 669397..670059 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 670056..670682 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 670803..672665 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 670843..670943 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 670903 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(671441) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(671442..671461) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(671474..671483) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 672711..674549 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 674707..675360 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 675368..677359 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 677403..679976 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(678725..678743) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678738) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678759..678764) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 680098..681606 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 681661..682617 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(681935) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(681961..682061) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(682001) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 682631..683518 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 683265..683270 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 683286..683304 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 683289 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 683527..684867 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(683961..685652) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 684868..684949 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 684950..685645 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 685643 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(685682..686008) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(685697) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 685995 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(686031..686050) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(686049) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(686065..686072) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(686112..686474) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(686497..686516) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(686511) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(686529..686535) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(686545..687105) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(686577) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(687088..687107) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687105) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687121..687130) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 687193..687200 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 687209 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 687213..687232 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 687258..687839 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 687833..688129 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 688121 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 688200..688207 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688221..688240 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688229 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 688284..688451 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 688493..688500 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 688516..688535 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 688517 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 688561..689205 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 689141 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 689185 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 689205..690197 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 690131 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 690175 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(690221..690724) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(690749..690768) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(690757) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(690782..690789) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 690887..691996 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 691979 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(692031..693101) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(692055) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(693132..693151) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(693158) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(693166..693173) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 693181..693187 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 693202..693220 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 693211 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 693251..696436 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 696423 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 696486..696491 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696507..696525 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 696528 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 696556..696559 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 696576..696595 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 696577..696882 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 696577 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 696883..698802 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 698801 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 698890..698899 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 698909..699037 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 698909 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 698913..698932 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(698963) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 699038..699802 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 699809..700777 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 700801..701712 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 701590..701599 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701612..701631 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701615 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 701741..702919 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 702460..702466 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702481..702500 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702495 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 702920..703855 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 703727 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 703837 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(703878) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(703886..705115) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(705144..705163) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705162) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705179..705186) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(705226..705933) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(705255) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(705956..705975) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(705979) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(706025..707410) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(706047) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(707459..707478) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(707476) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(707493..707500) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 707578..707585 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 707593 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 707599..707617 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 707660..709117 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(708453..708472) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(708467) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(708485..708494) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 709131..709991 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 709975 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 710059..710066 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 710080..710099 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 710085 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 710126..712015 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 711999 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 712079..712098 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 712087 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 712138..712584 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(712140) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(712224..712227) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(712229) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(712245..712246) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 712571 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 712647..712654 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 712668..712687 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 712680 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 712709..713131 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 712967 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 713197..714387 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(714451) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 714678..714833 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(714953..716509) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(714977) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 716339..716345 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716360..716371 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716377 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(716559..716578) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(716563) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(716594..716598) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 716619..716622 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 716638..716657 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 716641 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 716682..717812 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 717795 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 717880..718326 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(718379..719398) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(718389) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(719419..719438) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(719423) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(719425..719879) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(719451..719458) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 719517..719524 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 719538..719557 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 719545..720642 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 719545 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(719880..721100) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(721137..721156) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721144) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(721172..721179) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721198..721205 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 721217..721392 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 721217 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 721220..721239 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 721349 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 721436..722899 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(721801..723471) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 722900..723393 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 723381..723386 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 723395..726660 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 723395 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 723402..723420 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(723472..724272) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(724285..725286) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(724872..724891) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(724884) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(724906..724913) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(725283..726284) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(726354..726373) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(726356..727303) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(726375) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(726375) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 726630..726635 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 726651..726669 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 726662..727287 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 726662 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 727283..727302 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 727289..727820 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 727289 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(727345..727364) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727352) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727378..727385) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(727412..727780) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(727781..727893) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(727882..727901) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(727893) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(727913..727920) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 727961..727967 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 727981..727999 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 727981 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 728024..728371 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(728025) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 728367 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 728412..728492 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 728493..728512 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 728494 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 728562..729824 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 729819 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 729877..729880 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729895..729914 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729903 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 729951..731387 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 731379 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 731478..731497 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 731489 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 731514..733142 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 733114..733794 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 733797..734756 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 734725 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 734848..734855 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 734868..734887 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 734879..734951 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 734879 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 734952..736253 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 736250..736256 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736270..736281 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 736271 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 736309..737103 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 737079 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 737158..737161 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737176..737195 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737189 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 737222..738313 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(738304..738579) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 738314..738645 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(738593..738612) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(738607) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(738627..738634) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 738646..739311 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(739352..739489) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(739366) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(739490..739620) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(739606..739624) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 739616..739621 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(739620) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 739631..740695 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 739632 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 739637..739655 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(739640..739645) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(739646..739801) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(739802..739907) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(739908..740222) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(740223..740303) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(740304..741053) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(741082..741101) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(741095) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(741097..742233) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(741113..741121) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 741164..741165 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 741185..741204 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 741188 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 741225..742583 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(742219..742238) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742233) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742252..742261) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 742469 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 742579 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(742616..744565) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(742633) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 743675..743681 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 743697..743715 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 743701..744665 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 743701 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744566..744640) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(744617..744636) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(744640) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(744642..745164) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(744652..744656) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 744666..744803 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 744781 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 744782..744801 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 744822..745214 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(745162..745180) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(745177) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(745196..745201) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 745283..745289 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745304..745322 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745304 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 745339..746754 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(745340) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(745366..745466) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(745406) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(746751..747827) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 746755..750121 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(747851..748051) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(748067..749221) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(749202..750743) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(750793..750804) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(750796) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(750818..750824) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 750853..750860 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750875..750894 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750882 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(750928) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 750936..752348 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(750954..751054) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(750994) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 752419..754104 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(752725..752740) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752732) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752753..752762) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 754077..754081 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754097..754116 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754100 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 754125..754841 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 754834 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 754916..754919 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 754935..754954 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 754944 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 754981..755646 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 755627 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(755683..760071) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(755702) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(760104..760123) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(760121) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(760138..760141) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 760248..760254 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 760268..760286 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 760271 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 760314..760832 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 760818 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(760862) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 760863..762513 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(760872..762062) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(762063..762154) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(762155..762370) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(762214) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(762402..762421) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(762416) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(762436..762437) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 762483..762490 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 762505..762524 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 762515 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 762573..763043 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 763061..763381 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 763405..764232 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 764211..764217 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764232..764243 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 764250..764406 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 764250 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(764282) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 764381 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(764431..765606) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(764436) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 765043..765049 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765065..765083 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765069..765722 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 765069 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765631..765650) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765646) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765664..765671) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765712..765717 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 765724 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 765732..765750 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 765774..766829 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 766843..766849 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766864..766875 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 766868 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 766900..767694 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 767682 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(767733..768575) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(767735) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(768576..769697) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(769738..769757) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(769756) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(769773..769777) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 769785..769792 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 769806..769825 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 769816 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 769842..770027 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 770006 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 770070..770076 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 770082 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770091..770102 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 770128..770919 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 770917 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(770957..771817) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(770971) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(771837..771856) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771851) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771872..771875) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(771916..772875) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(771939) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(772886..772905) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(772889) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(772921..772924) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 772936..772940 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 772954..772973 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 772963 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 772994..773857 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 773858..773970 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 773971..775371 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 775383 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 775677..775684 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775700..775719 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 775706 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 775713..775996 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 775997..776263 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(776211..776230) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776229) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776245..776248) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 776264..776745 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 776716..776719 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776736..776755 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 776747..776994 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 776747 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 776995..777972 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 777973..778065 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 778022 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 778106..778112 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778124..778143 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778133 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 778168..778620 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 778650..779339 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 779344 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 779516..779534 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 779523 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 779571..780572 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 780576..781604 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 781618..782814 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(781619) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 782835..784211 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 784205 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 784258..784265 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 784278..784297 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 784286 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 784327..786144 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 786145..786151 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 786163 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 786166..786177 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 786198..786377 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 786361 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(786413..786742) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(786427) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(786792..787250) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(787251..787343) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(787344..787901) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 787767..787772 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787780 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787787..787805 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 787791..788378 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(787933..788700) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(788712..789935) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(789941..790255) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(790303..790322) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790316) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(790337..790340) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 790547..790566 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 790550 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 790591..791940 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 791969..791988 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 791971 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 792005..792769 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(792149..792163) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(792179..792185) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(792179) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 792784..794367 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 794347 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 794396..794403 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794418..794437 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794426 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 794473..796194 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 796188..798002 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 797977 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 798084..798091 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 798105..798124 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 798109 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 798157..798561 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 798579..799436 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 799423 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 799530..800474 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(800341) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(800389..800489) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800429) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 800649..802097 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 802124..803065 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 803075..804256 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 804246 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 804316..804322 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 804337..804356 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 804355 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 804380..805582 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 805579..806241 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 806249 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 806385..807320 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 807333..808523 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 808537..809694 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 808648..808653 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 808668..808686 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 808669 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(809692..809766) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(809735) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(809767..810315) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(810316..810395) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(810384..810403) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(810395) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(810417..810422) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 810518..810521 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810537..810556 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810544 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 810588..811220 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 811199 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 811335..811340 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811354..811373 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811364 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 811409..812497 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(811899..812287) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(812287) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(812289..812308) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(812321..812329) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(812533..813150) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(812551) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(813116..814369) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(813177..813196) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(813189) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(813210..813217) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(814403..814422) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814421) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814437..814444) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 814448..814467 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 814453 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 814493..815029 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(815026..816582) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(816604..816622) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816621) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816638..816641) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(816693..817175) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(816709) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(817200..817219) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(817216) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(817234..817240) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 817261..817268 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 817282..817301 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 817290 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 817347..819917 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 819888 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(819935..820912) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(819946) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 820927..820934 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(820939..820958) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 820949..820968 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 820951..821042 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 820951 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(820956) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820973..820980) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 821043..822044 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 822041..823072 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 823053 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 823123..823125 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 823141..823160 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 823144 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 823187..824068 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 824079..824086 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824102..824121 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824111 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 824156..824740 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 824727 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(824779..824970) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(824797) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(825002) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(825005..825016) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(825031..825037) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(825037..825147) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(825176..825187) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825178) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825202..825208) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(825202..826113) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 825999..826002 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 826019..826038 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 826029..826201 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 826029 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826135..826153) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826149) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826167..826173) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 826202..826996 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 826998..827312 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(827220..827488) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 827302 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 827386..827391 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827407..827426 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827412 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 827455..828648 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 828649..828883 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(828681..828833) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(828698) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828862..828869 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 828883..828902 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 828885..828957 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 828885 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(828892..828903) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(828902) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(828918..828924) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 828958..829227 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 829216 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 829305..829311 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 829326 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 829327..829345 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 829372..829890 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 829891..829958 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 829926..829935 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 829947..829962 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 829960 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 829975..830307 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 830294..831154 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 831152 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 831212..831218 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 831232..831243 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 831240..831304 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 831240 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831262..831281) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(831271) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 831287..831293 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(831295..831296) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 831306..831386 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 831306 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 831308..831326 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 831387..832376 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(831536) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(831541..831545) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(831562..831566) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832377..832447 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 832448..835033 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 835002 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(835026..836009) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(835060) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 835483..835492 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 835505..835524 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 835509 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(836010..836157) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 836114..836118 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 836134..836153 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 836141 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 836147..836224 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(836155..836174) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(836157) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(836189..836196) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 836225..837334 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 837171..837175 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837191..837210 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837203 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837335..837647 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(837342..837566) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(837596..837607) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837598) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837621..837627) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 837648..838400 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 838417..838423 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838438..838449 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838439 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(838446..838460) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(838467) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(838469..838473) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 838469..838723 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 838721 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(838746) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 838812..839156 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 838819..838827 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838838..838856 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838840 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 839139 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 839195..839202 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 839216..839235 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 839225..839299 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 839225 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 839300..839830 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 839821 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 839918..841660 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 841647 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(841737..842798) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(841748) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(842799..842889) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(842887..842906) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(842896) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(842921..842928) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(843018..844307) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(843021) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(844335..844354) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844354) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(844356..845067) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(844366..844371) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 844400..844407 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844421..844440 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844421 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 844460..844933 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 844970..844977 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 844992..845011 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 844998 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 845056..845493 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 845475 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(845528..845881) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 845541 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(845551) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 845877..845881 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 845889..845903 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(845893..845912) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 845893..845984 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 845893 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(845903) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 845961..845964 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 845979..845998 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 845986..846088 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 845986 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 846089..846973 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 846956..846963 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846977..846996 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 846992..847264 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 846992 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(847025) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 847265..848819 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 848987..851914 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 851915..852000 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 851976..851983 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 851997..852016 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 852002 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 852026..852141 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 852151..852225 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 852231..852322 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 852318 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 852357..852428 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 852438..852513 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 852523..852599 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 852611..852687 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 852700..852775 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 852781..852853 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 852876..852960 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 852966..853039 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 853064..853139 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 853149..853220 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 853270..853344 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 853350..853420 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 853428..853516 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 853517..853593 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 853550 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 853595..853763 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 853720..853727 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 853726 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 853741..853760 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853765 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 853782..853863 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(853799..853816) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(853802) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(853837..853842) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(853872) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(853942..854718) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(853956) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(854745..854760) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(854767) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(854773..854782) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 854802..854808 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 854823..854834 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 854826 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 854860..855063 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 855046 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(855122) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(855148..855420) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(855379..855397) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855386) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 855401..855408 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(855414..855419) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 855421..855440 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 855429 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 855462..856154 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 856183..856187 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(856186..856205) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856198) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 856201..856220 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(856220..856227) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 856224..856331 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 856231 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 856362 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 856464..858236 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 858212 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 858257..859182 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(858274..859629) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(859657..859676) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859674) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859690..859699) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859747..859753 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859768..859787 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859796 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 859880..860077 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(860104..861555) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(860114) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 861532..861538 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861553..861572 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861556 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861573..861592) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 861578..861907 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(861592) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861606..861613) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(861651..861669) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(861676) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 861864 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 861963..862730 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 862748..863746 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 863743..864573 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 864596..865726 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 865753..865772 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 865759 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 865830..866366 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 866367..866437 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 866407..866414 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866428..866447 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866439 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 866478..866747 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 866550..866554 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866577..866593 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866593 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 866734 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(866765..867238) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(866801) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(867240..867440) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(867469..867488) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(867483) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(867501..867508) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 867564..867569 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 867583..867602 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 867583 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 867634..867707 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 867708..867890 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(867798..868421) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(867813) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 867847 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 867892..868503 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(868445..868464) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(868466) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(868478..868485) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 868504..869664 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 869673 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 869690..869702 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 869695 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 869731..870666 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(869749) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 870650..870653 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 870668 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 870669..870688 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 870704..871186 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 871169 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 871236..871952 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 871256..871263 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 871278..871297 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 871279 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 871943..872656 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 872668..873375 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 873259 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 873303 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 873369 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(873402..873577) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(873445) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(873569..873588) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(873577) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(873603..873610) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 873642..873647 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873663..873681 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873663 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 873725..875620 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 874167..874267 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 874227 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 874293 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 875613 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 875677..875682 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875698..875716 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875701..875799 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 875701 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 875800..876978 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 875998..876001 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876016..876035 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876020 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(876261) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 876957 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 877065..877072 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877087..877106 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877087 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 877138..877602 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 877427..877433 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877448..877466 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877461 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 877611..877617 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877631..877642 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877637 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 877638..878303 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 878344..879942 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 879965..880495 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 880508..880882 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 880871 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 880882..881037 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 880972..880978 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880993..881012 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 881003 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 881042..881803 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(881355..881373) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(881369) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(881389..881394) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 881806..882171 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 882173..882871 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 882888..883805 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 883798..884739 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 884721 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(884831..885034) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(884845) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(885035..885162) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 885122..885133 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 885139 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(885151..885170) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885162) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885164..886302) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(885184..885189) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 885329..885336 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885351..885369 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885358 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 885359..885469 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 885470..886300 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 886259 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(886303..887382) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(887392..887411) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(887413) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(887427..887431) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 887489..887496 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887510..887529 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887516 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 887555..888946 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(888582..888985) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 888925 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(888986..889441) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(889456..889474) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(889484) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(889489..889495) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 889533..889539 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889553..889564 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889557 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 889591..890160 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 889787..889793 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 889804 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 889807..889818 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 890135 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 890203..890212 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 890226..890245 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 890236 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 890281..891249 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 891125 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(891181..891834) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(891198) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(891865..891876) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891867) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891891..891897) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891906..891914 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 891917..895570 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 891925..891943 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891940 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 895567..896163 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 896142 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(896193..897101) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 897157..897165 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(897158..897169) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897164) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(897166..897652) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 897176 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897179..897198 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(897183..897189) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 897212..897607 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(897638..897657) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(897652) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 897692..897698 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 897707 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 897712..897723 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(897722..897736) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(897736) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(897744..897748) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 897744..898166 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(898070..898170) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(898110) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 898144 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(898176) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 898216..898223 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 898237..898256 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 898245 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 898293..898955 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 898971..900512 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 900495 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 900596..900787 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 900818..900825 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 900840..900859 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 900851..900932 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 900851 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 900933..902285 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 902313..902891 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 902886..902893 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 902908..902927 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902919 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 902934 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 902979..903069 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 903070..903894 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 903913..905403 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 904714..904720 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 904735..904754 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 904745 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 905404..905492 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 905449 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 905455..905555 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 905515 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 905544..907211 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 906973..906978 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906993..907011 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 907002 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 907056..907062 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907077 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907078..907096 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 907179 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 907224..907297 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 907279..907286 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 907299 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 907300..907319 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 907343..909088 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 909077 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 909122..909191 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 909193..909212 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 909193 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 909237..910376 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 910373..911017 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 911014..911538 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 911503 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(911553..911795) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(911574) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(911831..911842) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(911842) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(911856..911863) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 911930..911936 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 911950..911961 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 911960 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 911996..912319 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 912320..914186 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(912361..913827) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(912373) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(912460) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(913867..913885) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913879) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913899..913906) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(913980..914420) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(914010) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 914408..914414 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 914428..914439 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 914430..914540 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 914430 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(914442..914461) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(914458) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(914473..914479) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 914499 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(914527..916185) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(914532) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(916076..916094) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916096) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916108..916114) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916157..916162 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916178..916196 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916191 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 916216..917622 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 917602 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(917652..919037) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(917678) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(919064) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(919066..920597) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(919074..919085) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 919193..919200 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919213..919232 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 919219..919506 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 919219 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 919469..919472 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 919487..919506 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 919508 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 919567..920571 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 920433 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 920563 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(920597) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(920604..920619) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 920609 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(920631..920640) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(920642..921517) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 921570..921571 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(921583..921602) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 921588..921607 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(921589) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 921598 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(921617..921622) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 921626..922726 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 922737..922743 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922758..922776 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922763 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 922800..923669 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 923677 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 923754..923757 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 923769 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 923772..923791 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 923817..923836 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 923822..923918 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 923822 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 923919..925316 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 925296 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 925377..925381 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925397..925416 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925404 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 925434..926789 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 926770 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(926824..928233) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 928282..928285 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 928300..928319 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 928302 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(928304..928323) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(928316) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(928339..928343) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 928343..928771 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 928750 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(928802..929092) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(928826) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(929080..930156) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(930146..930637) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(930638..930740) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(930729..930748) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930740) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930762..930765) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 930778..930784 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 930795 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 930799..930817 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(930828) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 930834..931829 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 931808 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 931891..931894 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 931909..931928 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 931914 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 931964..932563 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 932578 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 932623..934577 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(932632..933966) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(932651) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(934027..934458) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(934470..934489) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934480) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(934504..934510) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(934506..934606) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 934541..934548 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(934546) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 934562..934581 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 934579 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 934615..935796 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 935781 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 935826..935964 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 935960..935979 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 935966..936122 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 935966 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 936123..937508 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 937398 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 937484 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(937522..937878) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(937875..938270) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(938257..938988) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(939013..939032) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(939034) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 939081..939089 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939098 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939103..939118 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 939112..939185 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 939172..939173 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 939187 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 939189..939208 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 939222..939329 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 939330..939383 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 939354 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 939434..939453 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 939440 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 939478..940593 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 940573 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 940630..940649 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 940630 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 940663..941406 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 941378 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(941430..942278) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(941454) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 942274..942279 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(942279..942378) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 942295..942313 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 942297 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 942302..942497 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(942367..942386) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(942381) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(942401..942404) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 942496..942515 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 942499..942562 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 942499 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 942563..943411 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 943402 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(943454..944815) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(943478) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(944816..944886) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(944859..944878) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(944886) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(944942..945442) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(944974) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(945464..945482) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(945484) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(945497..945503) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 945521..945528 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 945536..945605 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 945537 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 945543..945562 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 945606..945767 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 945697 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 945768..945886 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 945887..947644 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 947641..949662 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 949650 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(949711..950331) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(949726) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 950316..950416 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(950345..950364) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950360) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(950370..950495) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 950376 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950379..950382) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(950509..950528) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(950518) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(950542..950551) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 950574 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(950600..950803) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(950605) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(950804..950914) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 950844..950944 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 950904 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(950920) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(950924..950935) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(950950..950956) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(951012..951230) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(951046) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(951271..951290) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951288) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951304..951311) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(951380..952741) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(951398) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(951442) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(952731..953822) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(953146..953160) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953158) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953174..953182) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(953823..953928) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(953912..953930) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(953932) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(953946..953951) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 953994..954001 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 954016..954035 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 954027 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 954089..955222 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 955223..955314 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 955315..955668 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 955656 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(955712..956785) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(955819) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(956807..956826) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(956819) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(956840..956847) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 956922..956929 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956942 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956944..956963 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 956953..957106 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 957063 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 957108..957191 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 957148 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 957204..957209 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 957225..957243 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 957234 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 957271..958137 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 958119 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 958182..958185 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958200..958219 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958208 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 958249..959754 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 959724 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(959772..960989) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(959778) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(960996..961493) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(961557..961895) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(961907..961926) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(961931) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(961940..961947) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 961967..961974 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 961989..962008 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 961999 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 962060..962827 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 962828 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(962848..963033) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(963069..963087) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963080) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963098..963106) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963107..963110 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963125..963144 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963135 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 963160..964056 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 964049..965308 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 965292 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 965356..965363 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965375..965394 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965380 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 965415..966641 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(966116) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 966646..969537 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 967927..967932 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 967948..967966 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 967954 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 969545..969550 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969565..969584 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969580 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 969611..970555 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 970533 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 970614..970619 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 970635..970653 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 970638 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 970680..970892 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 970885 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(970923) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(970933..971811) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(971121) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(971849..971868) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971873) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(971882..971889) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 971909..971918 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 971930 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 971931..971950 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(971967..971981) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(971968) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 971971..972057 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(971990..971994) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 972058..972309 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 972182..972268 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 972266 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(972278..972540) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 972311..972794 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(972321) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(972533..972552) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(972540) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(972542..972610) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(972566..972571) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(972611..973129) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 972916..972924 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972936..972954 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972949 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(973160..973179) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973178) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973195..973201) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973278..973281 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 973296..973315 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 973301 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 973337..973678 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(973532..973674) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(973575) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(973675..974286) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 973679..974444 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(973751) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 974282..974286 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974294..974307 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974306 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974311..974330) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(974334) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(974345..974348) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 974401 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(974464..974820) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(974468) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 974897..974902 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(974903..974922) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(974917) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 974918..974936 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974918 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974919..975182) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 974950..975141 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 975142..976577 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(975215..975733) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(975227) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(975734..975821) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(975813..975832) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(975821) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(975846..975853) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(975858..976937) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(976976..976995) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976987) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976989..977070) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(977084..977521) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(977115) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(977554..977573) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977568) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 977571 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(977587..977594) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(977593..977889) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(977636) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(977887..977898) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977893) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977913..977919) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 977949..977956 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977970..977989 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977979 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 978009..978752 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 978745..979971 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(979304..979322) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979319) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979338..979343) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 979991..980701 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 980665 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(980719..981909) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(980729) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(980794) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(981933..981952) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(981954) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(981966..981971) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(981982..983373) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(983384..983403) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983389) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983416..983425) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(983439..983753) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(983798..984298) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(983825) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(984311..984330) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 984313..984317 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(984332) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 984333..984352 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984334 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984347..984348) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 984365..984371 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 984386..984397 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 984391 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 984420..986564 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(984464..984475) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984467) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(984489..984495) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 986601..986607 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 986621..986640 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 986631 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 986686..987747 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 987819..988751 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 988766..990178 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 988769 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 990155 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 990239..990246 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 990260..990279 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 990265 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 990324..990899 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 990643..990646 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 990661 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 990663..990682 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 990900..990969 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 990970..993297 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 993279 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(993339..994316) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(993352) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(994330..994349) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994348) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994363..994369) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994375..994383 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 994394..994412 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 994401 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 994443..995219 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(994935..995556) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 995220..995591 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(995534..995553) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995555) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995567..995576) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995569..995576 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995591..995610 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995593 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 995632..996672 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 996685..997092 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 997063 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(997129..998418) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(997159) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(998419..998519) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(998518..998537) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998519) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(998521..998657) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(998552..998558) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(998689..998829) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(998702) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(998848..998867) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(998867) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(998880..998887) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 998911..998917 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 998931..998950 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 998934 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 998981..999715 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 999728..1000723 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1000788..1001432 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1001420 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1001460..1001463 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1001478..1001497 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1001485 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1001549..1003090 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1003070 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1003129..1003524) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1003146) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1003544..1003555) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1003548) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1003570..1003576) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003609..1003612 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1003620 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1003627..1003646 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1003673..1004953 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1004100..1004119) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1004114) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1004135..1004140) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1004940 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1004990) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1004992..1006137) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1006138..1006204) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1006193..1006212) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1006210) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1006228..1006232) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1006517..1006524 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1006539..1006558 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1006541 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1006572..1007021 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1007037..1007044 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007059..1007078 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007066 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1007093..1008085 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1008086 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1008131..1008241 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1008219..1008226 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008242..1008261 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008243 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1008302..1009273 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1009252 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1009305..1009886) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1009328) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1009910..1009929) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1009922) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1009945..1009948) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1009957..1011051) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1011048..1012487) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1012494..1013054) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1012504..1012523) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1012518) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1013079..1013098) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1013093) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1013113..1013120) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1013189..1014487) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1013200) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1014541..1014559) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014544) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014573..1014579) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1014626..1016155) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1016182..1016200) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016192) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1016211..1016216 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1016215..1016220) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1016228 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1016232..1016250 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1016267..1017124 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1017106 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1017152..1017385) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1017185) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1017402..1017421) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1017405..1017406 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017405 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017409..1017424 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017424) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1017426..1018281) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1017436..1017443) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1017608..1017615 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1017627..1017646 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1017633 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1017678..1018256 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1018257..1018402 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1018303..1019202) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1018326) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1018389..1018392 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018404 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1018410..1018414 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1018448 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1018493..1019359 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1019229..1019247) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019246) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1019262..1019268) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019336..1019343 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019358..1019377 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019361 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1019419..1019688 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1019680 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1019728) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1019731..1021200) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1021197..1021397) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1021398..1021516) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1021499..1021518) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021516) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1021531..1021538) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1021604) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1021605..1021967) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1021805..1021810 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021826..1021844 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021827 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1021836..1022075 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1021997..1022016) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022015) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022031..1022038) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022057..1022064 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1022077 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1022078..1022097 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1022119..1022742 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1022744..1023250 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1023243 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1023301..1023308 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023322..1023341 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1023331..1023430 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1023331 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1023431..1024930 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1024938..1024945 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1024957 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1024959..1024978 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1025007..1025534 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1025496 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1025548..>1025568) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1025568,1025584) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1025569..1025583 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1025584..1025870 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1025584..1025705) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1025590) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1025706..1026860) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1026861..1026932) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1026915..1026934) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026931) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026948..1026953) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1026967..1028172) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1028193..1028212 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1028198 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1028286..1030013 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1029599..1029606 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1029621..1029640 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1029628 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1030043..1030369) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1030487..1030924) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1030496) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030955..1030974) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030975) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030987..1030996) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1031044..1031051 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031065..1031084 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031077 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1031108..1034608 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1034595..1038293 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1038294..1038364 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1038365..1039540 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1039537..1042929 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1042184..1042190 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1042205..1042216 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1042212 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1042281..1043254) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1042943..1043245 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1043225 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1043299) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1043303..1043304 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1043323 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1043362..1043949) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1043964..1043983) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043983) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043999..1044001) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044004..1044010 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1044022 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1044025..1044043 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1044028..1044094 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1044095..1045939 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1045940..1046007 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1045964 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1046069..1046548) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1046568) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1046572..1046590) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1046601..1046609) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1046740..1046744 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1046757 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1046759..1046778 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1046780..1047604 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1046992..1046998 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047013..1047031 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047020 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1047614..1049064 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1047634..1049001) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1049033..1049040 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1049054..1049073 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1049066 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1049125..1049988 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1050006..1051019 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1051002 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1051071..1051078 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1051093..1051112 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1051112..1051227 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1051112 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1051228..1052256 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1052278 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1052307..1052816) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1052326) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052829..1052847) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052845) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052859..1052867) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1052866..1053528) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1053547..1053553 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1053567..1053586 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1053576 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1053595..1055049 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1054904..1055056) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1054939) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1055057..1055695) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1055696..1055830) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1055744..1055749 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055765..1055783 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055766 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1055776..1055900 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1055816..1055835) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055830) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055850..1055857) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1055901..1056707 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1056700 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1056735..1057334) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1056754) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1057331..1058500) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1058501..1058612) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1058613..1059323) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1059367..1059386) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1059389) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1059399..1059408) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1059438..1059447 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1059461..1059480 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1059472 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1059508..1060194 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1060191..1060949 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1060946 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1060994..1061623) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1061657..1061675) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1061674) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1061690..1061695) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1061719..1062834) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1061748) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1062843..1064111) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1064137..1064148) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1064146) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1064162..1064168) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1064223..1065071) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1064234) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1065076..1065525) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1065546..1065565) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065560) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065581..1065582) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1065615..1067453) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1065642) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1067535) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1067543..1067660) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1067712..1067731) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1067726) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1067746..1067753) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1067767..1068258) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1068276..1068279 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1068282..1068301) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1068294..1068313 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068295 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1068300) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1068316..1068323) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1068357..1069253 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1069240 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1069316) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1069328..1069329 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1069329..1069382 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1069329..1069343) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1069347) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1069361..1069366 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069381..1069399 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069384 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1069421..1070263 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1069916..1069924 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1069935..1069953 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069935 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070264..1070377 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1070378..1070737 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1070726 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1070768..1070965) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1070781) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1070966..1071162) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1071162) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1071164..1071175) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1071190..1071196) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1071222..1072034) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1072072..1072091) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1072092..1072099 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1072092) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1072105..1072112) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072111..1072130 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1072113 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1072155..1072922 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1072931..1072937 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1072951 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1072952..1072971 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1072986..1073294 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1073279 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1073324..1073589 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1073590..1075020 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1075065..1075559 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1075523 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1075697..1075704 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1075703 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1075718..1075737 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1075766..1076803 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1076823..1078043 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1078058..1078834 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1078831..1079988 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1080059..1081114 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1080669,1080670) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1080948..1080967) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1080958) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1081107..1084199 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1084187..1085146 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1085109 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1085149..1085423) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1085174..1085180 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1085182) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1085195..1085206 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085216 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1085232..1085411 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1085421 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1085457..1085642) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1085468) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085671..1085690) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085688) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085701..1085708) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085743..1085749 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085761..1085780 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085766 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1085823..1085832 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1085832 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1085845..1085864 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1085891..1086625 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1086384..1086986) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1086606..1086611 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1086624 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1086624 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1086627..1086645 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1086707..1087264 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1086966..1086985) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1086986) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087000..1087004) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087271..1087278 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087293..1087312 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1087305 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1087355..1088308 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1087972..1087976 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1087992..1088011 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1088005 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1088323..1088514 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1088493 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1088538..1088878 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1088544..1088783) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1088560) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1088796..1088815) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1088817) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1088829..1088838) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1088844..1088851 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1088866..1088885 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1088880 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1088948..1089886 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1089025..1089034 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1089043 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1089046..1089061 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1089909..1091150 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1090123..1090141) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090131) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090157..1090162) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1091001 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1091134 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1091175..1091184 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1091197..1091216 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1091199 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1091211..1091219 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1091226..1092011 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1091231..1091249 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1091243 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1092012..1092096 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1092028..1092046) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1092045) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1092061..1092066) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1092064..1092071 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1092086..1092105 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1092098..1092202 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1092098 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1092203..1093189 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1093186..1094175 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1094181..1094187 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1094186..1094262 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1094186 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1094263..1094754 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1094727..1095893 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1095884 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1095969..1096919 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1096936..1097847 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1097861 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1097906..1098013 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1097986..1097991 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1098007..1098025 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1098015 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1098052..1098804 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1098784 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1098839..1099831) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1098860) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1099890..1100104) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1099938) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1100123..1100142) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100136) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1100391..1100398 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1100412..1100574 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1100413..1100432 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1100413 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1100575..1102212 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1102106 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1102213..1102319 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1102320..1103255 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1102363..1102382) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1102380) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1102398..1102404) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1103259..1104176 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1104181..1105257 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1105259..1106176 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1106146 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1106226..1106229 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106242 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106244..1106263 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1106283..1107500 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1107553..1107562 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1107575..1107590 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1107584..1107663 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1107584 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1107664..1108242 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1108243..1108357 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1108294..1108313) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1108298) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1108327..1108334) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1108360..1108373 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1108360 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1108423..1108818 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1108654..1108754) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1108694) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1108816 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1108861..1109650 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1108861..1109517) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1109547..1109565) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109562) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109580..1109585) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109623..1109630 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109644..1109663 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1109652..1109793 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1109652 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1109687..1109827 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1109794..1110450 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1110440 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1110445..1110567) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1110485..1110574 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1110553..1110561 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1110572..1110590 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1110576..1110640 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1110576 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1110641..1111762 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1111416..1111422 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1111434 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1111437..1111455 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1111648..1111656 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1111668..1111686 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1111675 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1111756..1111762 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111777..1111788 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111786 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1111809..1113821 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1111884..1111891 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1111906..1111925 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1111918 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1113768 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1113822..1114123 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1113859..1114026) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1113872) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1114046..1114064) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1114062) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1114080..1114085) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1114116..1114123 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1114125..1114250 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1114125 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1114131..1114269 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1114138..1114157 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1114207 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1114340..1115239) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1114371) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1114575..1114580 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1114587 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1114596..1114614 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1114603..1116504 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1115236..1115634) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1115635..1115814) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1115806..1115825) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115814) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115837..1115844) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1115889..1116434) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1115913) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1116435..1116637) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1116638..1117210) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1116783..1116801) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1116792) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1116814..1116821) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1117239..1117258) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1117256) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1117272..1117275 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1117273..1117280) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1117288 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1117291..1117310 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1117335..1117703 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1117732..1118367 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1118386..1119186 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1119249..1120100 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1120059 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1120113..1120847) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1120135) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1120969..1120973 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1120990..1121009 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1121004 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1121005..1121081 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1121082..1122926 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1121409..1121428) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1121433) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1122928..1122935 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1122949..1122968 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1122955 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1122988..1123096 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1123091 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1123175..1123885 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1123860..1124477 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1124461..1125570 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1125570..1125770 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1125767..1126537 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1126534..1127544 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1127563..1128378 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1128352 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1128425..1128431 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1128444..1128463 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1128454 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1128514..1129290 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1129279 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1129294..1129295 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1129295..1130355 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1129299..1131578) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1129317) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1131453..1131627) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1131506..1131514 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131525..1131543 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1131529..1131664 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1131529 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1131615..1131634) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1131626) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1131642..1131648 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1131650..1131654) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1131663..1131681 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131666 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1131695..1131949 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1131925 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1132015) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1132022..1132444) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1132448..1132963) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1133000..1133722) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1133761..1133780) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1133782) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1133831..1133838 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133853..1133872 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1133857 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1133890..1134010 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1134015 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1134078..1135199 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1135192..1136364 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1136347 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1136381..1136399 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1136391 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1136392..1137921 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1136397..1136942) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1136418) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1137012..1138202) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1138228..1138247) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138232) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138262..1138269) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1138296..1138303 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1138307 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1138317..1138336 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1138375..1138447 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1138389..1138406) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138403) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1138427..1138433) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1138437 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1138462..1139197) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1138482..1140130 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1138491) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139199..1139287) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1139242) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1139288..1140517) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1139410) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1140087 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1140518..1140603) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1140558..1140565 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140580..1140599 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1140589..1140608) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140593 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1140607) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140621..1140627) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1140643..1140963 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1140973 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1141018..1141115 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1141116..1141247 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1141263..1141436 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1141473..1141934 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1141905..1141912 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1141927..1141946 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1141935..1142175 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1141935 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1142148..1142155 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142169..1142187 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142177 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1142200..1142703 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1142715..1142999 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1142969 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1143001) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1143012..1143015) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1143160..1143687 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1143834..1143839 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143852..1143871 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143855 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1143861..1144178 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1144179..1144414 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1144415..1145170 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1145171..1145258 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1145215 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1145258..1145318) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1145289) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1145319..1145666) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1145698..1145716) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1145711) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1145713..1146169) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1145727..1145735) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1146129..1146147 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1146141 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1146147..1146166) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1146169) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1146180..1146187) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1146217..1148163 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1148139 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1148193..1148194 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1148194..1148292 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1148267..1148273 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1148288..1148307 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1148294..1148362 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1148294 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1148363..1148845 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1148825 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1148891..1149397) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1148915) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1149422..1149441) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149428) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1149430..1149615) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1149616..1150011) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1150034..1150052) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150047) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1150049..1150749) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1150067..1150072) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1150155..1150162 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1150176..1150195 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1150187 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1150240..1150719 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1150718 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1150759..1150953) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1150794) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1150967..1150982) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1150983) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1150994..1151003) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1151119..1151448) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1151485..1151504) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151498) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151500..1152067) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1151519..1151524) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151552..1151556 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151572..1151591 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1151576..1152077 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1151576 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1152068..1153057) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1153058..1153077) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1153061) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1153091..1153096) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1153180..1153428) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1153190) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1153424..1153428 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153437..1153451 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1153446 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1153453..1153472) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153462) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1153486..1153495) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153543..1153550 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1153557..1153576) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1153564..1153583 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153566) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1153577 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1153578..1153681 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1153590..1153597) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1153682..1155085 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1155074 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1155125..1155598) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1155129) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1155620..1155638) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155638) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155653..1155658) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1155723..1155890) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1155726) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1155902..1155920) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155911) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155933..1155940) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1156017..1156916 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1156925..1157323) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1156955) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1157352..1157371) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157371) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157386..1157393) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1157424..1157999) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1157439) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158018..1158036) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158033) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158050..1158056) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1158074..1158080 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1158095..1158113 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1158096 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1158145..1161102 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1161095..1161655 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1161648 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1161693..1161811 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1161789..1161792 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1161808..1161827 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1161813 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1161852..1162493 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1161861) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1162466 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1162572..1163198 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1163200 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1163203) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1163229..1163507) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1163247) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1163536..1163547) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1163549..1163555) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1163555) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1163557..1163973) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1163725 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1163726..1163745 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163743..1163897 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1163898..1165088 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1163971..1163990) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1163973) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1164004..1164013) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1165111..1166289 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1166330..1166518) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1166346) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1166544..1166563) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166547) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166577..1166583) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1166605..1166612 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166627..1166646 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166638 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1166653..1166672) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1166657) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1166687..1166694) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1166692..1167504 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1167483 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1167550..1168302) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1167559) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1168302..1169054) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1169174..1170148) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1169209) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1170169..1170188) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1170195) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1170197..1172703) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1170203..1170210) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1170231..1170237 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170252..1170270 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1170255 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1170280..1170777 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1170778..1170891 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1170871..1170875 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1170891..1170910 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1170893..1171165 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1170893 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1171166..1171588 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1171628..1172806 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1172637..1172737 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1172695..1172713) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172697 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1172703) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1172725..1172733) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1172805 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1172914..1172921 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172936..1172955 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1172961 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1173004..1174425 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1174493..1175872 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1175012..1175031) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1175017) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1175045..1175052) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175897 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1175907..1175914 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1175909..1175976 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1175977..1176990 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1176996..1178015 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1178040..1179119 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1179116..1179952 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1180000..1181268 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1181212..1181215 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1181231..1181235 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1181233 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1181301..1181320 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1181301 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1181356..1182357 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1182039..1182139) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1182079) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1182333 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1182434..1183876 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1183873..1185366 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1185405..1186169) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1185424) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1185937,1185939) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1186196,1186203) /created_by="User" /modified_by="User" /label="TF8A" N_region 1186197..1186202 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1186205..1186525 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1186534 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1186543..1186746) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1186562..1186699) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1186586) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1186785..1186955) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1186791) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1186955..1187701) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1187536..1187555) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187553) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187571..1187578) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1187727..1187745) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1187740) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1187761..1187766) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1187811..1188812) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1187840) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1188825..1189442) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1189478..1189497) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189480) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1189482..1189579) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1189513..1189517) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1189559..1189578) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189579) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189593..1189600) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1189624..1189643) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1189636) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1189718..1191034) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1189733) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1191081..1191100) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1191097) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1191115..1191118) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1191317..1191324 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1191339..1191358 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1191351..1191422 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1191351 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1191423..1192373 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1192361 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1192474..1192620 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1192628..1194778 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1193517..1193617 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1193577 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1193665 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1194790..1195761 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1195118..1195759) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1195804) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1195829..1196195) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1195872) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1196175..1196190) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1196195) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1196202..1196211) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1196279..1197628) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1196293) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1197668..1197675 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1197680..1197699) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197688 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1197690..1197709 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1197698) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1197700..1197782) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1197710..1197717) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1197739..1197745 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197760..1197779 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197763 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1197765..1197784) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197782) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1197797..1198615 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1197800..1197803) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198593 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1198672..1198679 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198694..1198713 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198698 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1198744..1199568 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1199585..1200511 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1200517..1201479 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1201211..1201216 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201232..1201250 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201233 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1201484..1202491 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1202494..1204143 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1204137 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1204231..1205190 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1205187..1206287 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1206284..1207174 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1207187..1208176 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1207470..1208197) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1208166 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1208211..1209379 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1208219..1209268) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1208242) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1209295..1209314) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1209306) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1209329..1209336) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1209358..1210218) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1210243..1210261) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210260) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1210277..1210283) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1210292..1210299 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1210313..1210332 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1210320 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1210378..1210896 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1210887 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1210961..1210967 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1210979..1211085 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1210979 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1210981..1210992 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1211060..1211063 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211079..1211098 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211087 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1211135..1212334 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1212323 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1212368..1212739 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1212411..1212635) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1212715..1212721 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212735..1212746 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212741 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1212780..1213511 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1213489 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1213550..1213558 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1213569..1213587 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1213577 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1213603..1214130 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1214120..1214638 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1214632..1214639 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1214653..1214672 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1214656 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1214671..1214782 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1214745 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1214860..1215198 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1215198..1215515 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1215515..1215518 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215534..1215553 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215546 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1215586..1216488 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1216479 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1216535..1216541 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1216547 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1216555..1216574 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1216576..1216786 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1216744 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1216839..1217936 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1217026..1217028 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217030..1217034 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217030 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1217948..1219195 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1219186 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1219257..1219264 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1219279..1219298 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1219288 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1219321..1219746 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1219735 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1219777..1220220) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1219811) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1220247..1220266) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220253) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220281..1220284) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1220302..1220308 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220322..1220340 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220328 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1220363..1220773 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1220751 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1220800..1220970 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1220971..1221648 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1221020..1221490) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1221044) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1221512..1221531) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221528) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1221530..1221637) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1221547..1221550) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1221606 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1221663..1223951) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1221682) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1223952..1224014) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1223974..1224074) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1224014) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1224079..1224234) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1224080) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224267..1224286) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224279) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224281..1224366) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1224302..1224309) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1224367..1225326) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1225327..1225378) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1225371..1225390) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225383) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1225404..1225410) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225495..1225498 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1225511 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1225514..1225533 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1225549..1226382 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1226358 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1226413..1227177) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1226434) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1227152..1228795) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1228782..1229381) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1229383..1229985) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1230063) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1230082..1230194) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1230195..1230198 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1230209..1230228) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1230214..1230233 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1230225 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1230230) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1230243..1230250) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1230296..1230982 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1230986..1232350 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1232347..1233027 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1233056..1233061 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233077..1233095 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233080 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1233119..1233631 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1233617 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1233662..1233668 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233682..1233693 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1233683 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1233714..1233851 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1233824 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1233910..1233917 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1233931..1233950 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1233933..1234252 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1233933 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1233965..1234118 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1234230..1234239 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234252..1234271 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1234254..1234355 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1234254 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1234356..1235711 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1235702 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1235754..1236086) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1236102..1236121) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236112) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1236114..1236502) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1236137..1236142) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1236174..1236274 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1236234 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1236281..1236436 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1236445..1236452 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236459..1236476 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1236476 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1236487..1236506) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1236502) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1236520..1236526) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1236524..1236706 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1236674 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1236731..1236739 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1236750..1236768 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1236756..1236838 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1236756 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1236839..1237303 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1237288 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1237318..1238439) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1237727..1237735 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1237749..1237768 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1237752..1238530 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1237752 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1238468..1238479) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238488) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238494..1238500) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1238531..1239082 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1239050 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1239110..1239922) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1239882..1239901) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1239896) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1239915..1239920) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240023..1240029 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1240040..1240114 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1240040 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1240043..1240054 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1240115..1241809 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1241822..1242835 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1242820 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1242861..1244696) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1242910) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1244700..1245635) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1245606..1245617) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1245616) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1245632..1245638) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1245672..1248074) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1245704) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1247922..1248124) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1248113..1248131) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248124) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248145..1248152) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248191..1248198 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248212..1248231 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248224 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1248255..1248920 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1248789..1248808) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1248806) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1248822..1248831) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1248915..1248922 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1248937..1248956 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1248950 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1248976..1249109 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1248997..1249971 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1249060 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1249959 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1250081..1250089 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250103..1250111 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250113 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1250116..1250202 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1250175..1250182 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1250196..1250215 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1250204 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1250235..1250990 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1250987..1252132 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1252133..1253292 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1252143..1252337) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1252150) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1252380..1252391) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1252390) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1252406..1252412) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1252468..1253169) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1252502) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1253170..1253250) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1253242..1253261) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253250) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1253266..1253273 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1253275..1253282) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1253287..1253306 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1253294 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1253340..1254236 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1254230 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1254341..1254345 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254361..1254380 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254365 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1254410..1255759 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1255747 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1255808..1255814 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255828..1255839 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1255836..1255903 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1255836 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1255904..1256059 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1256062..1256238 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1256128..1256228 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1256188 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256234 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1256281..1257303) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1256304) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1257348..1257367) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1257364) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1257379..1257385) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1257492..1257500 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1257508 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1257511..1257529 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1257556..1259772 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1259547..1260487) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1259625..1259632 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1259647..1259666 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1259649 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1259769..1260266 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1260267..1260506 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1260356..1260481 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1260474 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1260515..1261576) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1260532) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1261584..1262777) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1261644 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1262864) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1262870..1263026) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1263061..1263080) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263062) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263096..1263103) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1263106..1263109 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1263110..1263889) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1263125..1263144 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1263134 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1263582..1263589 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1263602..1263621 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1263617 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1263624..1263941 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1263911..1263918 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263919..1263938) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1263933..1263952 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263933) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1263943 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263954..1263961) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1263984..1265180 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1265162..1265169 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265184..1265203 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1265203 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1265219..1265319 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1265318 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1265404..1266621 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1266618..1267325 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1267283..1267912 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1267927..1268463 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1268310..1268503) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1268463 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1268504..1268824) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1268562) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1268825..1268914) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1268850..1268856 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268871..1268889 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1268881 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1268882..1268966 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1268896..1268915) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1268913) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1268930..1268933) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1268940..1268947 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1268962..1268981 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1268968..1269026 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1268968 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1269024) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1269027..1269284 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1269278 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1269370..1269801 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" downshifts complement(1269841) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" SCAR join(1269876,1269986) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_027" N_region 1269877..1269985 /modified_by="User" /label="IIG_Bs27_027" CDS complement(1269996..1272095) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1269996..1272095) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1270018) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1272096..1272346) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1272306..1272406) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1272346) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1272382..1272387 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1272397 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1272403..1272421 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1272460..1273503 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1272460..1273503 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1273504..1273595 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1273572..1273576 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1273593..1273612 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273597 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1273642..1273686 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1273642..1273686 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1273663 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1273708..1273815 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1273816..1274475 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1273816..1274475 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1274468..1274917 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1274468..1274917 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1274910..1275641 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1274910..1275641 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1275659..1276156 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1275659..1276156 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1276157..1276433 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1276391 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1276401) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1276470..1276714) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1276511) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1276715..1277071) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1276715..1277071) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1277102..1277121) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1277119) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1277156..1277174 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1277161 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1277240..1277986 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1277240..1277986 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1278041 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1278389..1278397 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278411..1278430 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278415 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1278467..1279666 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1278467..1279666 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1278549..1278555 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1278570..1278588 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1278576 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1279635..1279637 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279657..1279675 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279669 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1279682..1279909 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1279682..1279909 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1279759..1279778) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1279767) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1279910..1280005 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1280006..1280704 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1280006..1280704 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1280657..1281483) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1280685..1280936 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1280685..1280936 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1281186..1281201 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1281209..1281420 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1281209 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1281385 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1281472..1281491) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1281494) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1281507..1281514) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1281559..1281566 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1281581..1281600 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1281583 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1281619..1281909 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1281619..1281909 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1281946..1282029) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1281989) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1282030..1282215) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1282030..1282215) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1282248..1282267) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282259) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1282261..1282605) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1282281..1282288) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1282314..1282319 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1282335..1282354 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282342 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1282381..1282575 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1282381..1282575 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1282551 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1282596..1282614) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1282612) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1282631..1282636) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1282874..1283500 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1282874..1283500 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1283431 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1283557..1283562 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1283569 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1283578..1283596 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1283618..1284955 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1283618..1284955 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1285006..1285503 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1285006..1285503 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1285352..1285358 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1285367 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1285373..1285391 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1285477 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1285598..1285604 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285615..1285634 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285627 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1285631..1285738 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1285739..1287652 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1285739..1287652 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1285888..1285907) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1285905) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1285920..1285929) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1286056..1286075) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1286081) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1286089..1286095) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1287633 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1287709) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1287920..1287939) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287929) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287953..1287960) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1288004..1288023 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1288014 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1288059..1289150 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1288059..1289150 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1288799 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1289129 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1289163..1289381) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1289174..1289431 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1289368..1289387) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1289381) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1289403..1289410) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1289432..1290397 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1289432..1290397 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1290415..1290422 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1290437..1290456 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1290449 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1290460..1291326 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1290460..1291326 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1291181..1291185 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291202..1291221 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291210 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1291328 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1291373..1291524 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1291373..1291524 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1291373..1291524 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1291502..1291508 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291522..1291533 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291526 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1291555..1293654 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1291555..1293654 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1293672..1293676 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293692..1293711 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293703 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1293752..1294018 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1293752..1294018 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1294018..1295730 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1294018..1295730 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1295717 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1295770..1295776 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1295791..1295802 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1295794 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1295821..1296060 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1295821..1296060 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1295841..1297180) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1296138..1297166 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1296138..1297166 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1297136 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1297181..1297861) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1297181..1297861) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1297871..1297890) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1297894) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1297905..1297912) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1297946..1297953 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1297967..1297985 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1297973 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1297996..1299963 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1297996..1299963 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1298436..1298451) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1298448) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1299934 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1300007..1300009 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1300025..1300044 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1300035 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1300077) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1300101..1300967 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1300101..1300967 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1300947 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301006..1301779) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1301006..1301779) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1301023) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1301811..1301830) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1301821) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1302054..1302073 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1302067 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1302069..1302172 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1302116..1304230 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1302116..1304230 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1303409..1303427) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303421) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303443..1303448) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1304211 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1304303..1304311 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1304323..1304341 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304335 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1304394..1306214 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1304394..1306214 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1306225..1307406) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1306225..1307406) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1306259) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1307434..1307453) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307450) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1307482..1307500) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307494) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1307496..1307564) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1307515..1307520) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1307558..1307577) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307564) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1307608..1307769) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1307608..1307769) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1307792..1307811) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1307805) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1307825..1307832) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1307906..1307913 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1307925 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1307926..1307944 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1307973..1308884 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1307973..1308884 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1307978) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1308427..1308435 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308449..1308466 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1308452 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1308869 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1308928..1309392) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1308928..1309392) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1308946) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1309422..1309441) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1309432) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1309456..1309463) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1309518..1310810) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1309518..1310810) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1309540) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1310834..1310853) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1310838) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1310869..1310873) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1310886..1311380) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1310886..1311380) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1311396..1311415) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1311412) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1311429..1311438) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1311437..1312297) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1311437..1312297) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1312318..1312337) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1312331) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1312368..1312375 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1312391..1312410 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1312404 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1312440..1313204 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1312440..1313204 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1313205..1313353 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1313334..1313352 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1313355..1313504 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1313355 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1313402) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1313505..1315235 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1313505..1315235 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1315301..1315819 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1315301..1315819 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1315817 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1315862..1315867 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1315880..1315899 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1315883 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1315915..1316463 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1315915..1316463 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1316464..1316615 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1316616..1317839 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1316616..1317839 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1317802..1317820) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1317812) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1317818 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1317835..1317840) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1317888..1317895 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1317907..1318008 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1317907 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1317910..1317929 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1317925..1318008 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1317925..1318008 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1317965 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1318019..1318024 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1318039..1318323 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1318039 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1318041..1318059 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1318300..1318306 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1318320..1318331 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1318325..1318412 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1318325 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1318401..1318420 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1318414 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1318485..1318724 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1318485..1318724 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1318725..1318833 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1318834..1319352 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1318834..1319352 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1319389..1319396 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1319410..1319429 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1319424 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1319486..1319683 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1319486..1319683 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1319679 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1319724..1319820 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1319821..1320264 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1319821..1320264 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1320265..1320372 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1320340..1320345 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1320360..1320379 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1320374 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1320413..1321294 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1320413..1321294 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1321273 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1321329..1321336 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1321351..1321370 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1321356 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1321406..1321882 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1321406..1321882 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1321872..1322765 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1321872..1322765 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1322781..1323236 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1322781..1323236 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1323052..1323071) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323065) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1323085..1323093) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1323230 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1323275..1323282 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1323296..1323315 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1323297 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1323341..1324051 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1323341..1324051 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1323350) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1323460..1323464) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323460) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1324121..1325245 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1324121..1325245 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1325257..1325263 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325277..1325288 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325279 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1325283..1325297) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1325307..1325311) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1325307..1325552 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1325307..1325552 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1325308) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1325540 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1325585..1326535 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1325589..1326392) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1325589..1326392) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1325601) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326443..1326462) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326452) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326476..1326483) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1326508..1326515 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1326530..1326549 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1326537..1326628 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1326537 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1326629..1327171 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1326629..1327171 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1327243..1327689 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1327243..1327689 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1327697 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328082..1328089 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1328102 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1328104..1328123 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1328155..1328730 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1328155..1328730 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1328708 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1328771..1329736) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1328771..1329736) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1328784) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1329080..1329081 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329099..1329118 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329105..1329829 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1329105 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1329757..1329775) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329778) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1329790..1329795) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1329816..1329822 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1329832 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1329836..1329855 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1329873..1330472 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1329873..1330472 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1330523..1331542 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1330523..1331542 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1331560..1332852 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1331560..1332852 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1332813..1333334 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1332813..1333334 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1333334..1333807 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1333334..1333807 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1333800..1334033 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1333800..1334033 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1334012 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1334078..1334083 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1334100..1334118 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1334108 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1334120..1334206 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1334196..1334199 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1334208 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1334214..1334233 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1334257..1336014 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1334257..1336014 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1336026..1337840 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1336026..1337840 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1336463..1336482) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1336473) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1336497..1336504) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337891..1337900 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1337912..1337927 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337916 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1337950..1338645 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1337950..1338645 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1338650..1339783 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1338650..1339783 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1339784..1340476 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1339784..1340476 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1340473..1341666 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1340473..1341666 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1341644 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1341715..1341721 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341735..1341746 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341743 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1341788..1341795 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1341810..1341829 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1341815..1341906 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1341815 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1341870..1341877 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1341891..1341910 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1341908 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1341946..1342701 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1341946..1342701 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1342094) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1342096..1342098) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1342698..1343609 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1342698..1343609 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1343624..1345531 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1343624..1345531 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1345516 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1345600..1345607 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345618..1345637 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345621 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1345676..1346257 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1345676..1346257 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1346242 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1346286 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1346291..1346560) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1346291..1346560) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1346296) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1346561..1346626) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1346607..1346626) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1346626) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1346679..1346686 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1346697..1346716 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1346701 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1346741..1348363 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1346741..1348363 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1348351 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1348420..1349331 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1348420..1349331 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1349336 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1349365..1350597) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1349365..1350597) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1349376) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1350615..1350634) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350639) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1350649..1350654) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350707..1350841) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1350707..1350841) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1350718) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1350863..1350881) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1350874) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1350876..1350941) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1350897..1350902) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1350942..1351949) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1350942..1351949) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1351995) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1351996..1352004) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1352018..1352026) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1352136..1352145 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1352157 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1352158..1352173 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1352160..1352232 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1352233..1352511 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1352233..1352511 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1352509 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1352543..1354172) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1352554..1352658 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1352566) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1352640..1352647 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352659..1352678 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352660 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1352701..1353987 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1352701..1353987 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1354003..1354836 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1354003..1354836 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1354169..1354187) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1354184) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1354203..1354208) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1354899..1355564 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1354899..1355564 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1355548 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1355655..1355661 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1355676..1355695) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1355676..1355695 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355688 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1355690) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1355719..1357452 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1355719..1357452 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1356847..1357451) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1357441 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1357486..1359153) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1357486..1359153) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1357496) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1359159..1359368) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1359159..1359368) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1359405..1359424) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359427) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1359429..1359606) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1359439..1359442) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1359607) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1359609..1359620) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1359634..1359640) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359679..1359686 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359700..1359719 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359716 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1359754..1360527 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1359754..1360527 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1360498 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1360563..1361117) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1360563..1361117) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1360574) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1361139..1361158) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361149) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1361173..1361180) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1361202 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1361226) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1361227..1361385) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1361227..1361385) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1361292..1361435) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1361292..1361435) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1361381..1361385 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1361386..1361454) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1361395..1361409 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361422 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1361438..1361457) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1361467) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1361470..1361479) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1361541..1361548 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361562..1361581 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361566 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1361599..1362270 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1361599..1362270 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1361938..1361947 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1361960..1361978 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361972 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1362217 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1362445..1362450 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1362467..1362486 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1362468..1362693 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1362468 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1362472..1362491) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1362488) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1362592..1362600) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1362598) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1362614..1362622) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1362694..1363809 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1362694..1363809 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1363813..1364790 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1363813..1364790 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1364791..1364904 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1364825..1364844) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364842) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364859..1364862) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1364905..1366233 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1364905..1366233 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1365049..1365056 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365071..1365090 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365074 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1366238..1367650 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1366238..1367650 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1367647 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1367695..1368069) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1367695..1368069) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1367743) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1368100..1368119) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1368110) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1368273..1368278 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1368294..1368312 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1368304 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1368308..1368417 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1368340) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1368401..1368408 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1368419 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1368423..1368442 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1368438..1368648 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1368438..1368648 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1368488..1368607 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1368488..1368607 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1368494) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1368594 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1368639..>1370238 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1368647..1370119) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1368647..1370119) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1368665) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1370120..1370215) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1370198..1370217) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370215) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1370222..1370225 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1370232..>1370238) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 1370238..1370239 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_019" CDS 1370436..1372376 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1370436..1372376 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1372366..1372635 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1372366..1372635 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1372601..1372605 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1372619..1372638 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1372632 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1372635..1373156 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1372635..1373156 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1373153..1373446 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1373153..1373446 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1373486..1374097) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1373486..1374097) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1373500) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1374129..1374148) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374138) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1374163..1374166) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1374353) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1374370..1374558) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1374370..1374558) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1374424) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1374580..1374599) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1374597) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1374612..1374619) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1374625..1374644 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1374632 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1374671..1376509 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1374671..1376509 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1376566..1376883 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1376566..1376883 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1376857 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1376932) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1376939..1377148) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1376939..1377148) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1377162..1377181) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1377177) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1377231..1377860) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1377231..1377860) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1377262) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1377762..1377780) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1377768) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1377792..1377800) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1377895..1377906) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1377900) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1377912..1377917 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1377921..1377927) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377933..1377951 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1377933 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1377934..1378014 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1378015..1379343 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1378015..1379343 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1379199..1379346) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1379242) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1379344..1379934 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1379347..1379832) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1379347..1379832) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1379844..1379863) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379872) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1379878..1379885) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1379935..1380864 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1379935..1380864 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1380449..1380468 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380458 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1380888..1380891 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1380906..1380925 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1380914 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1380962..1381243 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1380962..1381243 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1381232 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1381306..1381309 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1381322..1381448 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1381322 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1381327..1381333 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1381449..1382660 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1381449..1382660 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1382670..1382674 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382689..1382708 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382708 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382735..1386181 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1382735..1386181 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1385747..1385765) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385767) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385781..1385786) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1386161 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1386206 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1386238) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1386250 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1386584..1387504) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1386584..1387504) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1386590) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387544..1387563) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387559) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387577..1387584) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1387639..1387646 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387660..1387679 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1387661..1387766 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1387661 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1387768..1387858 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1387768 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1387774..1387777 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1387792..1387808 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1387859..1388776 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1387859..1388776 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1388805 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1388824 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1388825..1388830 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1388884..1388889 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1388904..1388922 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1388912..1389015 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1388912 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1389016..1390086 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1389016..1390086 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1390119..1391987 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1390119..1391987 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1391987..1392610 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1391987..1392610 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1392613..1392945 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1392613..1392945 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1392972..1393865 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1392972..1393865 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1393840 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1393897..1394259) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1393897..1394259) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1393916) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1394252..1394256 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394265..1394278 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1394283..1394302) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1394287..1394398 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1394287 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1394295) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1394317..1394324) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1394399..1394845 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1394399..1394845 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1394431..1394438 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394450..1394469 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394455 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1394854..1394861 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394875..1394894 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394886 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1394929..1395969 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1394929..1395969 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1395892..1395910) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395897) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1395926..1395931) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1395949 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1396133..1396142 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396156..1396175 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396170 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1396201..1396599 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1396201..1396599 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1396205) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1396615..1396854 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1396615..1396854 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1396833 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1396921..1396928 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1396939..1396958 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1396944 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1396970..1397419 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1396970..1397419 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1397405 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1397474..1397746 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1397474..1397746 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1397551..1397774) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1397749..1397869 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1397749..1397869 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1397776..1397899) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1397819) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1397870..1397975 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1397900..1397912) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397907) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397927..1397933) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1397956..1397960 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1397976..1397995 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1397977..1398068 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1397977 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1398069..1398623 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1398069..1398623 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1398628..1399113 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1398628..1399113 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1399080 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1399124..1400350) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1399124..1400350) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1399125..1400399 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1400351..1400452) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1400374..1400381 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400393..1400412 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1400401..1400530 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1400401 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1400447..1400465) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1400462) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1400482..1400487) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1400531..1401313 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1400531..1401313 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1401093..1401099 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1401113..1401124 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1401124 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1401315..1402340 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1401315..1402340 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1402224 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1402357..1403604) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1402357..1403604) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1402384) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1403521..1403527 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1403541..1403552 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1403545 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1403601..1403786) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1403601..1403786) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1403619..1403623 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1403639..1403658 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1403648..1403783 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1403648 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1403677..1403696) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1403687) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1403710..1403717) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1403754..1403761 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403775..1403794 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403785 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1403814..1404332 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1403814..1404332 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1404354..1404533 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1404354..1404533 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1404513 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1404556) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1404560..1404563) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1404614..1404619 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1404635..1404653 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1404636 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1404679..1405260 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1404679..1405260 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1405261 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1405317..1405799) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1405317..1405799) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1405336) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1405789 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1405822..1405841) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1405841) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1405855..1405862) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1405899..1405905 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1405917..1405936 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1405919 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1405959..1406855 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1405959..1406855 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1406926..1408545 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1406926..1408545 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1408517 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1408579..1408582 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1408597..1408670 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1408597..1408616 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408597 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1408654) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1408671..1409102 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1408671..1409102 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1409172..1410107 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1409172..1410107 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1409774..1411226) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1410147..1410500 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1410147..1410500 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1410497..1412647 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1410497..1412647 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1411207..1411225) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411226) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411240..1411246) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1412630 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1412702..1412707 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1412723..1412741 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1412723 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1412764..1414704 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1412764..1414704 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1414500..1414506 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1414521..1414529 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1414527 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1414677 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1414722..1414789 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1414759..1414763 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1414779..1414798 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1414791..1414879 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1414791 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1414880..1416364 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1414880..1416364 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1416365..1416475 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1416476..1417450 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1416476..1417450 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1417451..1418806 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1417451..1418806 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1418630..1418635 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1418651..1418669 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1418661 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1418867..1419967 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1418867..1419967 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1419968..1420089 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1420090..1421181 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1420090..1421181 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1420570..1420579 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1420592..1420607 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1420597 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1420603..1420703 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1420663 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1421213..1422124 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1421213..1422124 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1422142 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1422254..1423045 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1422254..1423045 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1423042..1423737 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1423042..1423737 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1423760..1424467 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1423760..1424467 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1424485..1424850 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1424485..1424850 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1424702..1424705 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1424721..1424740 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1424737 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1424851..1425023 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1425024..1426346 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1425024..1426346 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1425231) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1425235..1425239) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1425254..1425258) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1426382..1427530 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1426382..1427530 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1427504 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1427625,1427632) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1427626..1427631 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1427632..1427677 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1427642..1427649 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1427662..1427681 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1427679 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1427736..1428530 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1427736..1428530 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1428448..1428451 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1428466..1428485 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1428474 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1428543..1428644 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1428543..1428644 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1428631 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1428732..1430012 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1428732..1430012 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1429953..1429969) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1429958) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1430033..1430038 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1430054..1430072 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1430058 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1430095..1430340 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1430095..1430340 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1430256..1430264 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430275..1430293 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430283 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1430341..1430451 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1430443..1430462 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1430453 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1430503..1431339 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1430503..1431339 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1431346..1432038 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1431346..1432038 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1432035..1432490 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1432035..1432490 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1432497..1432769 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1432497..1432769 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1432758 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1432830..1433603 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1432830..1433603 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1433319..1433326 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1433340..1433358 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433363 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1433604..1433696 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1433697..1434191 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1433697..1434191 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1434204..1434211 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1434225..1434244 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1434232 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1434254..1434480 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1434254..1434480 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1434447 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1434533..1437298 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1434533..1437298 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1437289 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1437344) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1437379..1437385 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1437400..1437411 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1437400 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1437443..1437817 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1437443..1437817 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1437849..1437853 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1437868 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1437869..1437888 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1437920..1438384 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1437920..1438384 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1438386..1439297 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1438386..1439297 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1439292..1439299 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1439314..1439333 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1439328 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1439337..1439453 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1439337..1439453 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1439480..1440025 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1439480..1440025 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1439674) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1440016 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1440029..1440146 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1440029..1440146 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1440199..1441506 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1440199..1441506 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1441507..1441621 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1441507..1441621 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1441652..1442566 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1441652..1442566 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1442550..1443836 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1442550..1443836 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1443833..1444927 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1443833..1444927 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1444912..1448127 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1444912..1448127 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1448124..1448894 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1448124..1448894 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1448894..1449829 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1448894..1449829 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1449798..1450517 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1449798..1450517 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1450496..1451146 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1450496..1451146 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1451148 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1451193..1451265 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1451245..1451252 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1451266..1451285 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1451267 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1451291..1451396 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1451291..1451396 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1451397..1451557 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1451558..1452259 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1451558..1452259 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1452271..1453335 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1452271..1453335 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1453384..1454532 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1453384..1454532 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1453473) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1453485..1453489) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1453507..1453508) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454545..1455138 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1454545..1455138 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1455139..1455236 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1455237..1456010 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1455237..1456010 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1455915..1455922 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1455937..1455956 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1455938 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1456013..1456798 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1456013..1456798 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1456779..1457267 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1456779..1457267 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1457247 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1457294) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1457307..1459025) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1457307..1459025) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1459047..1459066) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1459061..1459066 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1459061) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1459079..1459084) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1459082..1459100 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1459086 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1459141..1461813 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1459141..1461813 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1460546..1460565) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1460557) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1460580..1460587) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1461819..1461838 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1461822..1461895 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1461822 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1461896..1462771 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1461896..1462771 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1462848..1463117 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1462848..1463117 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1462928..1462932) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1462933) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1463125..1463739 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1463125..1463739 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1463743..1463946 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1463743..1463946 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1463935 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1464027..1465247 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1464027..1465247 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1465086..1465661) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1465244..1467661 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1465244..1467661 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1465657..1465675) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1465661) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1465689..1465695) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1467512..1467516 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1467532..1467551 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467543 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1467688..1468170 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1467688..1468170 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1468175..1469128 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1468175..1469128 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1469115..1470458 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1469115..1470458 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1470462..1471553 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1470462..1471553 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1471560..1472324 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1471560..1472324 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1471613 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1472318..1474264 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1472318..1474264 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1474173..1474179 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1474193..1474211 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1474209 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1474279..1475175 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1474279..1475175 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1475180..1475833 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1475180..1475833 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1475831..1475840 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1475854..1475873 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1475859 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1475906..1476550 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1475906..1476550 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1476311..1476317 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1476328 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1476332..1476350 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1476441..1476446 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1476462..1476480 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1476475 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1476551..1476621 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1476622..1476702 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1476622..1476702 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1476717 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1476762..1477134 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1476775..1476963) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1476775..1476963) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1476791) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1476837) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1476964..1477056) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1477038..1477057) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1477056) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1477073..1477076) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1477107..1477114 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1477129..1477147 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1477136 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1477175..1477178 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1477193..1477212 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1477201 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1477240..1477602 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1477240..1477602 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1477453) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1477618..1479279 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1477618..1479279 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1479280..1479369 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1479342..1479349 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1479363..1479382 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1479371 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1479418..1480080 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1479418..1480080 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1480106..1481008 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1480106..1481008 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1480986..1483034 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1480986..1483034 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1483070..1483077 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1483092..1483111 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1483098 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1483143..1483709 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1483143..1483709 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1483723..1484724 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1483723..1484724 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1484743..1485696 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1484743..1485696 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1485689..1486429 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1485689..1486429 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1486460..1486464 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1486480..1486499 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1486485 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1486513..1486746 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1486513..1486746 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1486727 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1486755..1486855 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1486815..1486885 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1486815 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1486886..1487635 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1486886..1487635 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1487607 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1487677..1487683 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487695..1487714 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487717 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1487736..1491296 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1487736..1491296 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1491230..1492300) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1491316..1492305 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1491316..1492305 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1492292 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1492342..1492827) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1492342..1492827) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1492345) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1492849..1492867) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1492865) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1492881..1492888) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1492930..1492936 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1492951..1492970 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1492953 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1493004..1493336 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1493004..1493336 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1493007) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1493350..1494690 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1493350..1494690 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1494691..1494795 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1494796..1495068 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1494796..1495068 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1495068..1495313 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1495068..1495313 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1495285 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1495330..1495434 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1495435..1495821 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1495435..1495821 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1495826..1496350 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1495826..1496350 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1496347..1497078 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1496347..1497078 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1497084..1497091 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1497105..1497124 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1497109 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1497157..1497198 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1497157..1497198 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1497218..1497565 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1497218..1497565 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1497567 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1497620..1497626 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1497639..1497707 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1497639 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1497640..1497659 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1497708..1498556 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1497708..1498556 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1498577..1498584 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1498597..1498615 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1498607 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1498627..1499394 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1498627..1499394 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1499426..1501156 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1499426..1501156 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1500663) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1500664..1500683) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1500698..1500705) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1501153..1501434 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1501153..1501434 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1501266 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1501435..1501554 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1501526..1501533 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1501547..1501566 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1501556 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1501607..1502764 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1501607..1502764 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1501679..1501779) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1501719) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1502793..1503695 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1502793..1503695 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1503685 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1503756..1504649 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1503756..1504649 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1504655..1504662 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1504677..1504696 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1504684..1504836 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1504684 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1504837..1506912 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1504837..1506912 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1506882 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1506944..1506949 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1506956 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1506965..1506983 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1506988..1508295 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1506988..1508295 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1508301..1508305 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1508322..1508341 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1508332 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1508363..1509277 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1508363..1509277 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1508402..1508406 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1508419 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1508422..1508441 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1509290..1509835 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1509290..1509835 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1509852..1511255 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1509852..1511255 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1511295..1512074 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1511295..1512074 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1512049 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1512093 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1512194..1512201 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512214..1512232 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1512225..1512378 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1512225 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1512353..1512360 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512375..1512394 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1512380 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1512454..1512843 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1512454..1512843 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1512843..1513295 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1512843..1513295 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1513296..1513297 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1513352..1514116 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1513352..1514116 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1514126..1514132 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1514145..1514648 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1514145..1514648 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1514147..1514158 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1514161 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1514644..1514650 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1514665..1514684 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1514667..1514791 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1514667 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1514792..1515532 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1514792..1515532 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1515514 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1515559..1515633 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1515634..1516515 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1515634..1516515 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1516516..1516660 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1516661..1517383 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1516661..1517383 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1517385..1517942 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1517385..1517942 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1517889) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1517931..1517934 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1517949..1517968 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1517967..1518072 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1517967 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1518073..1518855 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1518073..1518855 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1518859..1519668 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1518859..1519668 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1519649..1519656 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1519671..1519690 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1519672 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1519730..1520881 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1519730..1520881 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1520888..1522156 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1520888..1522156 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1522189..1523883 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1522189..1523883 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1523884..1523991 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1523992..1528305 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1523992..1528305 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1528306..1528370 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1528316..1528533 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1528316..1528533 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1528342..1528348 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1528363..1528374 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1528372..1528439 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1528372 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1528422..1528428 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1528441..1528634 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1528441 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1528442..1528461 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1528635..1529105 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1528635..1529105 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1528956) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1529140..1530255 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1529140..1530255 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1529202..1529302) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1529242) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1530269..1530544 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1530269..1530544 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1530546..1530848 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1530546..1530848 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1530868..1533018 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1530868..1533018 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1532913..1532919 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1532928 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1532934..1532952 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1533015..1533293 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1533015..1533293 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1533310..1533663 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1533310..1533663 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1533654 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1533745..1534674 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1533745..1534674 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1534459..1534466 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1534480..1534499 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1534489 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1534693..1535643 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1534693..1535643 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1535676..1535682 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1535683..1535799 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1535683 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1535697..1535716 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1535800..1536069 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1535800..1536069 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1536052 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1536097..1536182 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1536163..1536166 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1536182..1536201 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1536184 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1536242..1538359 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1536242..1538359 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1538142 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1538343 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1538388..1538476 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1538477..1539436 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1538477..1539436 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1538545..1538553) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1538548) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1538567..1538574) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1539040..1539045 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1539061..1539079 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1539066 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1539476..1540705 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1539476..1540705 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1540694 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1540734..1540739 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1540749 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1540755..1540773 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1540783..1541040 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1540783..1541040 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1541041..1541095 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1541068 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1541137..1541146 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1541156..1541225 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1541156 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1541160..1541179 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1541226..1542119 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1541226..1542119 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1542122..1542724 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1542122..1542724 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1542778..1542797 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1542778..1542849 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1542778 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1542850..1543890 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1542850..1543890 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1543891..1543981 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1543982..1545196 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1543982..1545196 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1545227..1546099 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1545227..1546099 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1545570..1546754) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1546106 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1546199..1546202 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1546216 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1546218..1546237 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1546277..1547944 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1546277..1547944 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1546741..1546759) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1546758) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1546775..1546780) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1547932 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1547999..1548005 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1548019..1548030 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1548020 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1548060..1548797 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1548060..1548797 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1548794..1549006 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1548794..1549006 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1549034..1549053 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1549048 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1549137..1551500 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1549137..1551500 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1551501..1551601 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1551562..1551569 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1551584..1551603 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1551602 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1551644..1552369 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1551644..1552369 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1552356 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1552425..1552431 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1552444 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1552446..1552457 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1552508..1553716 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1552508..1553716 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1553674 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1553785..1553792 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1553805..1553824 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1553827 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1553839..1553842 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1553858..1553870 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1553872 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1553896..1555176 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1553896..1555176 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1555173..1556459 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1555173..1556459 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1556309 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1556460..1556513 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1556514..1557242 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1556514..1557242 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1557258..1557264 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1557276 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1557278..1557289 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1557289) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1557300..1557314) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1557323..1557327) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1557323..1557580 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1557323..1557580 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1557565 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1557597) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1557638..1557641 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1557656..1557675 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1557656 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1557710..1558225 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1557710..1558225 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1558161..1558499 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1558161..1558499 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1558566..1559432 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1558566..1559432 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1558629..1558729 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1558689 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1559392 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1559482..1560063 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1559482..1560063 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1560081..1561331 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1560081..1561331 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1561332..1561458 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1561438..1561445 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1561460..1561479 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1561460 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1561504..1562550 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1561504..1562550 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1562562 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1562607..1562672 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1562644..1562653 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1562666..1562681 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1562674 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1562718..1563893 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1562718..1563893 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1563894..1563993 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1563967..1563974 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1563988..1564007 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1563995..1564168 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1563995 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1564169..1565731 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1564169..1565731 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1565708 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1565800..1566594 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1565800..1566594 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1566349..1566354 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1566370..1566388 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1566390 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1566638..1566643 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1566654..1566793 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1566654 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1566659..1566677 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1566686) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1566697..1566710) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1566719..1566723) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1566730) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1566794..1567054 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1566794..1567054 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1567006 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1567038) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1567050 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567095..1567269 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1567253..1567260 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1567271 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1567275..1567294 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1567320..1568363 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1567320..1568363 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1568376..1569554 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1568376..1569554 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1569536 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1569634..1569637 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1569646 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1569652..1569671 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1569702..1571231 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1569702..1571231 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1571233..1571664 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1571233..1571664 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1571647 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1571795..1571800 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1571816..1571834 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1571824..1571925 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1571824 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1571926..1572471 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1571926..1572471 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1572465 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1572472) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1572529..1572532 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1572547..1572566 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1572551 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1572604..1575180 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1572604..1575180 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1575196..1577079 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1575196..1577079 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1576982..1577476) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1576994 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1577004) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1577226..1577233 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577248..1577267 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1577258..1577391 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1577258 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1577263..1577413) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1577263..1577413) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1577348 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1577477..1577932) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1577477..1577932) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1577933..1578024) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1578012..1578031) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1578024) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1578048..1578051) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1578087..1578644) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1578087..1578644) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1578735..1578736 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1578787) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1578793..1579149) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1578793..1579149) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1579209..1579222) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1579214) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1579228..1580052) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1579228..1580052) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1580074..1580093) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1580090) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1580105..1580111) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1580163..1581491) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1580163..1581491) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1580170) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1581514..1581533) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1581533) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1581547..1581555) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1581648..1581655 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1581663..1581682) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1581671..1581690 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1581674) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1581677 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1581695..1581702) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1581716..1581793 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1581716..1581793 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1581718) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1581771..1581947 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1581771..1581947 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1581928 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1581973..1582161 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1582156..1582175 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1582163 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1582227..1582934 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1582227..1582934 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1582945..1582951 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1582965..1582984 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1582969 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1583004..1583456 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1583004..1583456 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1583444 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1583470..1583823) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1583470..1583823) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1583511) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1583837..1584154) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1583837..1584154) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1584198..1584217) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584206) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584232..1584239) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1584291..1584566) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1584291..1584566) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1584292) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1584562..1584567 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1584583..1584601 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1584593..1584612) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1584603 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1584606) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584625..1584634) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1584655..1585068 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1584655..1585068 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1585119 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1585125..1585144 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1585168..1586112 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1585168..1586112 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1586092..1586100 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1586111..1586129 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1586113 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1586152..1586373 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1586152..1586373 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1586163) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1586225..1586229) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1586229) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1586244..1586249) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1586373 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1586569..1586841 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1586569..1586841 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1586857..1586864 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1586878..1586897 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1586880 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1586923..1587153 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1586923..1587153 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1587154..1587230 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1587187 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1587232..1587339 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1587312..1587319 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1587333..1587352 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1587341 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1587396..1587788 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1587396..1587788 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1587748..1589850 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1587748..1589850 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1589868..1590857 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1589868..1590857 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1590817 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1590871..1591530) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1590886) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1590907..1591527 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1590907..1591527 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1591508 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1591543..1591547 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1591565..1591932 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1591565 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1591569..1591586 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1591575) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1591591..1592358) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1591591..1592358) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1592367..1592386) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592390) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1592399..1592408) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1592512..1592517 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1592533..1592551 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1592533 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1592815..1592820 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1592837..1592855 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1592841..1592981 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1592841 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1592982..1593950 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1592982..1593950 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1593919 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1594014..1594022 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1594029 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1594033..1594052 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1594083..1595345 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1594083..1595345 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1595363..1596628 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1595363..1596628 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1596676..1596683 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1596698..1596717 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1596710 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1596738..1597145 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1596738..1597145 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1596744) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1597126..1597144 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1597151 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1597204) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1597204..1598538 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1597204..1598538 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1598515 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1598560..>1598609 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1598609..1598610 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1598610..1599362 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1598702..1598720) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1598720) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1598736..1598741) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1599363..1600754 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1599363..1600754 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1600785..1602386 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1600785..1602386 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1600901..1601206) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1601201..1601220) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1601206) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1601234..1601242) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1602384 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1602523..1603677) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1602523..1603677) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1602526) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1603576..1603754) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1603722..1603728 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1603737..1603756) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1603738..1603754 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1603748 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1603754) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1603771..1603774) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1603781..1603788 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603803..1603822 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1603814..1603918 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1603815 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1603919..1605256 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1603919..1605256 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1605257..1605331 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1605288 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1605407..1606906 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1605407..1606906 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1606907..1607222 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1607180 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1607389..1608024) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1607389..1608024) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1608061..1608080) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1608070) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1608095..1608102) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1608212..1608219 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1608234..1608253 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1608236..1608434 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1608236 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1608435..1609850 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1608435..1609850 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1609840 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1609943) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1609952..1611136) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1609952..1611136) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1611137..1611216) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1611209..1611227) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1611220) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1611243..1611248) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1611528..1611535 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1611550..1611569 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1611558 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1611600..1612061 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1611600..1612061 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1612091..1612525 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1612091..1612525 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1612274..1612579) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1612372 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1612526..1613622 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1612581..1612866) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1612624) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1612861..1612880) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612866) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612892..1612897) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1613128) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1613128..1613388) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1613128..1613388) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1613409..1613428) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1613419) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1613441..1613450) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1613623..1613748 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1613623..1613748 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1613749..1613865 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1613792..1613956 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1613792..1613956 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1613840..1613849 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1613863..1613882 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1613867..1614177 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1613867 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1614158..1614165 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1614179..1614198 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1614179 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1614230..1615069 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1614230..1615069 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1614252..1614271) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1614273) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1614286..1614289) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1615029 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1615175) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1615176..1615482) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1615192..1615479) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1615192..1615479) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1615219) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1615306..1615314 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1615328..1615347 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1615330 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1615341..1615501 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1615473 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1615522..1616244) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1615522..1616244) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1615527) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1616269..1616288) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1616277) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1616279..1616403) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1616404..1616760) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1616404..1616760) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1616784..1616803) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1616801) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1616819..1616823) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1617000) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1617006..1617206) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1617006..1617206) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1617189 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1617228..1617247) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1617240) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1617260..1617269) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1617381..1617569) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1617381..1617569) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1617397) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1617538..1617545) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1617551) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1617598..1617617) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1617616) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1617632..1617639) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1617648..1617785 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1617648..1617785 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1617679..1617684 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1617699..1617717 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1617717..1617819 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1617717 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1617820..1618218 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1617820..1618218 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1618219..1619023 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1618283..1618717) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1618283..1618717) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1618299) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1618747..1618766) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1618763) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1618780..1618787) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1619024..1619212 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1619024..1619212 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1619213..1619298 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1619257 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1619327..1619333 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1619345..1619504 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1619345 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1619347..1619358 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1619505..1621067 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1619505..1621067 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1619808..1619827) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619817) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1619842..1619849) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1621097..1622188 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1621097..1622188 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1622178..1623392 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1622178..1623392 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1623470..1623477 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1623492..1623511 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1623503 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1623539..1624345 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1623539..1624345 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1624153..1625251) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1624350..1624967 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1624350..1624967 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1624964..1626604 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1624964..1626604 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1625238..1625257) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1625251) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625271..1625279) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1626244..1627010) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1626641..1627006 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1626641..1627006 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1626983 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1627003..1627283) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1627003..1627283) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1627012..1627143) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1627055) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1627103..1627112 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1627125..1627134) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1627126..1627145 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1627131 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1627133..1627231 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1627143) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1627145..1627275) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1627232..1627990 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1627232..1627990 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1627265 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1627281..1627300) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1627282) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1627315..1627322) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1627805..1628016) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1627969 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1628014..1628633 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1628017..1628556) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1628017..1628556) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1628557..1628571) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628563) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628585..1628591) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1628611..1628620 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1628633..1628648 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1628635 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1628674..1629108 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1628674..1629108 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1628966..1629313 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1628966..1629313 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1629109..1629441 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1629400..1629409 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1629421..1629436 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1629443..1629621 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1629443 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1629512..1629591 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1629512..1629591 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1629578 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1629650..1630267) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1629650..1630267) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1629651) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1630291..1630310) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630312) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630324..1630331) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1630347..1630354 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1630366 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1630368..1630387 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1630417..1630734 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1630417..1630734 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1630434..1630452) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630437) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630466..1630473) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1630753..1631406 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1630753..1631406 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1631409..1631416 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1631430..1631449 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1631443 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1631470..1631703 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1631470..1631703 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1631704..1631839 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1631807..1631814 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1631828..1631847 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1631841 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1631872..1633875 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1631872..1633875 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1632076..1632095) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1632093) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1633865 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1633877..1634535) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1633975 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1633976..1633995 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1634028..1634474 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1634028..1634474 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1634498..1634517 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1634506 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1634517..1634534) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1634535) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1634553..1634557) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1634560..1634778 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1634560..1634778 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1634790 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1634835..1635134 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1634852..1635025) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1634852..1635025) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1634865) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1635063..1635082) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1635070) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1635096..1635103) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1635105..1635113 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1635125..1635144) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1635125..1635143 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1635136..1635244 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1635136 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1635137) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1635159..1635166) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1635245..1635952 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1635245..1635952 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1635972..1635979 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1635991..1636010 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1635999 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1636041..1636403 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1636041..1636403 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1636421..1636424 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1636439..1636458 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1636450 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1636482..1636973 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1636482..1636973 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1636969 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1637004..1637432) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1637004..1637432) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1637021) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1637450..1637469) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637462) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1637464..1637549) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1637483..1637490) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1637520..1637529 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1637539..1637648 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1637539 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1637542..1637561 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1637544..1637563) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1637549) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1637551..1637634) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1637578..1637581) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1637605 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1637666..1638058) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1637666..1638058) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1637679) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1637901..1637906 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1637922..1637940 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1637926 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1638036..1638040 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1638050..1638064 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1638065..1638084) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1638067 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1638080) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638098..1638107) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1638139..1638285) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1638139..1638285) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1638160) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1638317..1638463) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1638317..1638463) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1638463..1638596 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1638463 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1638474..1638476 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1638479..1638490) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1638493) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638505..1638511) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1638586..1638593 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1638598..1638690 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1638598 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1638608..1638627 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1638649) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1638691..1641420 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1638691..1641420 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1638711..1638715) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1638715) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1641421..1641491 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1641492..1642004 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1641492..1642004 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1641961 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1642030..1642036 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1642049 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1642051..1642062 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1642085..1642210 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1642085..1642210 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1642103) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1642224..1642230 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1642245..1642256 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1642247 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1642275..1642421 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1642275..1642421 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1642458..1642709 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1642458..1642709 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1642687 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1642730..1642735 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1642749..1642768 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1642753..1642844 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1642753 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1642845..1643210 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1642845..1643210 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1643226..1643525 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1643226..1643525 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1643501 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1643556..1643843) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1643556..1643843) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1643577) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1643643) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1643873..1643892) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1643885) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1643908..1643915) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1643931..1644512) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1643931..1644512) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1644513..1644643 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1644538..1644557) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1644555) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1644628..1644631 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1644645 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1644647..1644666 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1644682..1645089 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1644682..1645089 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1645085 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1645151..1645154 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1645169..1645188 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1645173..1645487 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1645173 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1645488..1647455 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1645488..1647455 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1647459..1649879 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1647459..1649879 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1649859 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1649887..1650076) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1649926..1650102) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1649926..1650102) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1649930) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1650077..1650487) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1650077..1650487) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1650460..1650479) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650463) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1650494..1650501) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1650528..1650547) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650529) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1650562..1650569) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1650576..1650595) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1650587) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1650609..1650618) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1650835..1650840 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1650853..1650872 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1650858 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1650871..1650935 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1650936..1652333 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1650936..1652333 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1652322 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1652367 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1652423..1653169) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1652546..1652553 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1652565 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1652566..1652585 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1652636..1654135 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1652636..1654135 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1653168..1653187) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1653191) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1653201..1653210) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1654083 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1654203..1654466 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1654203..1654466 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1654725) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1654725..1655993) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1654725..1655993) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1655994..1656123) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1656124..1657665) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1656124..1657665) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1657666..1657987) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1657977..1657996) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1657988) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1658011..1658014) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1658214..1658221 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1658234..1658253 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1658241 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1658260..1658706 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1658260..1658706 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1658713..1659606 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1658713..1659606 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1659223..1659242 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1659231 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1659679..1660275 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1659679..1660275 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1660265 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1660324..1661523) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1660324..1661523) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1661524..1661595) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1661583..1661594) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661595) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661609..1661615) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1661693..1663228) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1661693..1663228) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1661705) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1663239..1664021) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1663239..1664021) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1664042..1664941) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1664042..1664941) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1664956..1665177) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1664956..1665177) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1665192..1666526) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1665192..1666526) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1666536..1668185) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1666536..1668185) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1666585..1666685 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1666645 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1668229..1669371) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1668229..1669371) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1669390..1669408) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669407) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669424..1669429) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1669462..1669767) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1669462..1669767) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1669757..1669930) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1669757..1669930) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1670038..1671570) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1670038..1671570) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1670049) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1671605..1671624) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1671605) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1671637..1671646) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1671706..1672098) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1671706..1672098) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1671737) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1672126..1672137) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672133) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672151..1672157) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1672205,1672212) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1672206..1672211 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1672212..1672317) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1672302..1672321) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672317) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672335..1672342) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1672591..1674066) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1672591..1674066) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1672603) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1674100..1675077) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1674100..1675077) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1675106..1675124) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1675118) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1675136..1675144) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1675211..1676602) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1675211..1676602) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1675225) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1675371 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1676392..1676398 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1676412..1676430 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1676423..1676756 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1676423 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1676603..1676707) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1676667..1676767) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1676707) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1676729..1676734 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1676750..1676768 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1676758 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1676816..1676823 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1676836..1676855 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1676839 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1676888..1677433 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1676888..1677433 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1677417 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1677527..1677599) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1677527..1677599) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1677625) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1677652..1678197) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1677652..1678197) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1678237..1678256) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678251) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678270..1678277) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1678513..1678743) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1678513..1678743) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1678527) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1678769..1678788) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1678781) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1678800..1678806) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1678835..1678854) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1678845) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1678858..1678865 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1678879..1678898 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1678883 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1678928..1680691 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1678928..1680691 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1680672 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1680792..1681649) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1680792..1681649) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1681695..1681714) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1681715) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1681728..1681735) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1681777..1682766 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1681777..1682766 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1681833..1682791) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1682823..1684304) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1682823..1684304) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1682836) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1684321..1688883) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1684321..1688883) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1687344..1687444 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1687404 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1688884..1688955) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1688935..1688954) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1688952..1688959 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1688955) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1688969..1688976) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1688971 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1688974..1688993 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1689030..1689932 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1689030..1689932 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1689912 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1689984..1691099) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1689984..1691099) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1691096..1691989) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1691096..1691989) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1691994..1692013) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1692002 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1692012) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692027..1692033) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1692042..1692060) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1692060) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1692076..1692081) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1692137..1692505) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1692137..1692505) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1692540..1692558) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1692563) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1692565..1692684) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1692570..1692578) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1692676..1692695) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1692684) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1692686..1692782) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1692710..1692717) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1692805..1693521) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1692805..1693521) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1692827) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1693559..1693578) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693568) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693594..1693597) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1693622..1693628 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1693642..1693660 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1693647 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1693672..1693977 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1693672..1693977 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1693961 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1694048..1694818 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1694048..1694818 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1694800..1694807 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1694819 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1694822..1694841 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1694862..1695395 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1694862..1695395 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1695396..1695481 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1695438 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1695474..1696718) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1695474..1696718) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1695483..1696222 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1695488) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1696719..1696811) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1696812..1698275) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1696812..1698275) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1698293..1699327) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1698293..1699327) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1699339..1699410) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1699382) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1699411..1699502) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1699411..1699502) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1699530..1699549) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1699542) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1699564..1699571) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1699584..1699591 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1699605..1699624 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1699609 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1699651..1701693 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1699651..1701693 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1701701..1701710 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1701723..1701738 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1701726 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1701760..1702053 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1701760..1702053 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1702033 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1702078..1702425) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1702109) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1702426..1702830) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1702426..1702830) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1702831..1702926) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1702916..1702931) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1702916..1703035) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1702916..1703035) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1702926) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702944..1702953) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1703031..1703037 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1703051..1703062 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1703062..1703270 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1703062 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1703105..1703227 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1703105..1703227 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1703271..1703564 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1703271..1703564 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1703565..1703658 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1703615 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1703680..1705365) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1703680..1705365) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1703692) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1705366..1705453) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1705445..1705463) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1705453) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1705477..1705484) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1705622..1705631 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1705641 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1705644..1705663 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1705690..1707141 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1705690..1707141 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1707117 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1707178..1707876) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1707178..1707876) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1707193) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1707911..1707930) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1707930) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1707932..1708145) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1707944..1707951) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1708146..1708823) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1708146..1708823) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1708824..1711313) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1708996..1710033 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1708996..1710033 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1710230..1710236 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1710251..1710262 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1710263 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1710290..1710973 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1710290..1710973 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1711314..1711619) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1711314..1711619) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1711620..1711721) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1711700..1711719) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1711721) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1711734..1711741) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1711749..1711851) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1711791) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1711852..1713030) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1711852..1713030) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1713056..1713075) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1713075) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1713089..1713098) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1713153..1713641) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1713153..1713641) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1713178) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1713666..1713821) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1713666..1713821) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1713861..1714616) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1713861..1714616) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1714869..1714874 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1714890..1714908 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1714905 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1714924..1715280 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1714924..1715280 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1715239..1715478) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1715239..1715478) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1715281..1715717 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1715479..1715580) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1715581..1716078) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1715581..1716078) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1716079..1716178) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1716179..1717090) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1716179..1717090) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1717112..1717123) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717114) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717138..1717144) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1717374..1717381 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1717390 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1717396..1717415 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1717437..1717919 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1717437..1717919 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1717929..1718183 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1717929..1718183 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1718184..1718288 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1718289..1719083 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1718289..1719083 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1719084..1720094 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1719207..1720079) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1719207..1720079) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1720180..1721058 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1720180..1721058 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1721171..1721230) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1721206) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1721231..1721662) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1721231..1721662) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1721682..1721701) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1721690) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1721692..1721925) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1721715..1721721) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1721926..1721944) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1721926..1722558) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1721926..1722558) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1721932) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1721960..1721965) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1722696..1722703 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722718..1722737 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1722722 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1722784..1723704 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1722784..1723704 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1723215..1723234) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723230) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723249..1723256) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1723705..1724362 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1724201..1724563) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1724201..1724563) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1724624..1724836) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1724624..1724836) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1724875..1724882 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1724897..1724916 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1724900 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1724940..1725203 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1724940..1725203 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1725181 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1725580..1728180) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1725580..1728180) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1728181..1728290) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1728206..1728213 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1728228..1728247 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1728236..1728863 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1728236 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1728280..1728299) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728290) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728314..1728320) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1728336..1728795) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1728378) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1728840) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1728850..1729491) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1728850..1729491) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1729492..1729609) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1729586..1729605) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729609) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729619..1729621) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1729697,1729704) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1729698..1729703 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1729704..1729788 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1729704..1729781 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1729704..1729768) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1729704..1729788 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1729766 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1729799..1730131) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1729799..1730131) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1729813) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1730196..1730921) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1730196..1730921) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1730936..1731679) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1730936..1731679) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1731707..1731726) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1731726) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1731740..1731746) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1731757..1732332) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1731757..1732332) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1732338..1733039) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1732338..1733039) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1733069..1733088) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733069) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1733073..1733088) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1733103..1733110) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1733103..1733110) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1733113) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1733116..1733598) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1733116..1733598) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1733637..1733654) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1733641) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1733652..1734593) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1733652..1734593) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1733685) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1734623..1734642) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734631) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734656..1734660) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1734664..1734673 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1734686..1734705 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1734694 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1734709..1734773 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1734745..1734750 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1734766..1734784 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1734775 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1734799..1735344 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1734799..1735344 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1735303 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1735371..1735694) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1735371..1735694) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1735378) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1735715..1735734) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735726) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735747..1735754) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1735815..1735821 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1735832 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1735836..1735855 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1735888..1736565 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1735888..1736565 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1736557 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1736655..1737191) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1736655..1737191) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1736678) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1737218..1737237) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737238) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1737251..1737258) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1737328..1738110) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1737328..1738110) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1737337) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1738132..1738150) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738151) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738164..1738170) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1738207..1738214 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1738229..1738248 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1738233 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1738281..1738778 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1738281..1738778 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1738785..1738788 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1738804..1738823 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1738806 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1738842..1739819 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1738842..1739819 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1739791 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1739916..1739923 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739938..1739957 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1739945 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1739981..1741039 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1739981..1741039 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1741040..1741109 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1741093..1741099 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1741111..1741130 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1741111 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1741159..1742271 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1741159..1742271 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1742290..1742889 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1742290..1742889 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1742827 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1742871 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1742911..1743409) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1742947) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1743381..1743390 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1743393..1743411) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1743402..1743596 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1743402 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1743403..1743422 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743409) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1743428..1743433) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1743484..1744347) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1743484..1744347) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1743497) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1743553 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1743585) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1743598..1744365 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1744343..1744347 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1744356..1744370 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1744367 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1744386..1744405) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744399) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1744401..1744594) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1744417..1744423) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1744595..1746370) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1744595..1746370) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1746371..1746501) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1746494..1746696) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1746494..1746696) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1746546) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1746694..1746713) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1746712) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1746714..1746906) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1746726..1746733) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1746935..1747561) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1746935..1747561) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1746951) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1747595..1747614) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1747608) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1747628..1747635) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1747712..1748203) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1747712..1748203) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1747721) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1748215..1748233) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1748227) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1748247..1748253) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1748278..1748610) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1748278..1748610) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1748611..1748901) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1748626..1748631 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1748646..1748664 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1748648 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1748688..1748915 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1748688..1748915 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1748902..1749378) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1748902..1749378) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1748916..1749423 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1749379..1749481) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1749396..1749401 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1749416..1749434 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1749425 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1749445..1749708 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1749445..1749708 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1749461..1749480) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749481) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1749483..1750008) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1749494..1749498) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1749713..1749946 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1749713..1749946 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1749933 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1750032..1750376) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1750032..1750376) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1750053) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1750377..1750449) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1750445..1750464) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750449) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1750451..1750554) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1750478..1750483) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1750541..1750556) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750554) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1750569..1750578) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1750697) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1750733..1750936) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1750733..1750936) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1750957..1750976) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1750975) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1750977..1751043) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1750992..1750999) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1751009..1751016 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1751028 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1751030..1751042) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1751030..1751049 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1751033..1751165 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1751054) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1751166..1752653 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1751166..1752653 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1751609..1751626) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1751615) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1751639..1751647) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1752639 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1752701..1752706 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1752722..1752740 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1752727 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1752754..1754652 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1752754..1754652 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1753697..1753716) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753705) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753730..1753739) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1754642..1755487 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1754642..1755487 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1755488..1756994 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1755520..1756857) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1755520..1756857) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1755531) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1756885..1756904) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756900) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1756902..1758060) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1756919..1756926) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1756978..1756981 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756996..1757015 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1756996 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1757076..1758041 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1757076..1758041 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1758029 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1758091..1759344) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1758091..1759344) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1758105) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1759360..1762194) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1759360..1762194) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1762289..1762308) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762304) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762306..1762422) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1762323..1762330) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1762423..1764339) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1762423..1764339) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1764350..1765264) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1764350..1765264) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1765268..1765287) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1765283) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1765304..1765308) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1765328..1765918) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1765328..1765918) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1766011..1767255) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1766011..1767255) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1766013) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1767318..1767336) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767331) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1767333..1767553) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1767349..1767356) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1767539..1767557) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1767553) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1767569..1767577) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1767637..1768854) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1767637..1768854) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1767663) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1768887..1768906) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768895) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1768920..1768927) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1769090..1769713) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1769090..1769713) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1769714..1769864) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1769740..1769746 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1769752 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1769760..1769771 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1769778..1769786 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1769794..1769894 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1769798..1769816 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1769809 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1769847..1769865) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1769854..1769939 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1769854 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1769864) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769881..1769887) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1769915..1769922 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1769935..1769954 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1769941 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1769979..1771337 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1769979..1771337 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1770321..1770332) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1770326) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1770346..1770352) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1771353..1772201 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1771353..1772201 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1771617..1771636) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771624) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771650..1771658) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1772164 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1772196) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1772227..1772892) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1772227..1772892) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1772241) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1772911..1773261) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1772911..1773261) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1773258..1773536) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1773258..1773536) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1773563..1773582) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773579) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1773597..1773603) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1773612..1774508) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1773612..1774508) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1774350..1774359 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1774370 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1774373..1774392 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1774388..1774606 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1774532..1774551) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1774552) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1774563..1774570) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1774607..1775080 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1774607..1775080 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1775077 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1775115..1775351) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1775115..1775351) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1775123) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1775374..1775393) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1775389) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1775407..1775416) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1775436..1776770) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1775436..1776770) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1776771..1776906) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1776903..1776922) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776913) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776937..1776944) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1777002..1777009 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1777024..1777043 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1777027 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1777028..1777134 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1777135..1777524 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1777135..1777524 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1777534 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1777931..1778269) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1777931..1778269) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1778292..1778299 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1778313..1778332 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1778322 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1778326..1778398 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1778357..1778376) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778360) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778388..1778394) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1778399..1779007 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1778399..1779007 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1778997 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1779050..1779652) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1779050..1779652) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1779668..1780579) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1779668..1780579) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1780608..1780627) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780624) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780643..1780648) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1780700..1780703 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1780718..1780737 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1780720 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1780763..1780963 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1780763..1780963 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1780963..1782453 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1780963..1782453 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1781698..1781709) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781702) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781723..1781729) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1782441 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1782488..1783888) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1782488..1783888) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1782512) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1783659..1783668 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1783680..1783695 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1783694 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1783908..1783927) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783928) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1783941..1783948) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1783987..1783996 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1784002 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1784009..1784028 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1784041..1784742 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1784041..1784742 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1784767..1784775 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1784789..1784808 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1784794 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1784830..1785081 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1784830..1785081 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1785102 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1785152..1785973) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1785152..1785973) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1785178) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1785974..1786055) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1786056..1786757) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1786056..1786757) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1786758..1786847) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1786832..1786851) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786847) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786867..1786871) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1786905..1786911 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1786926..1786937 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1786943 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1786959..1787084 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1786959..1787084 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1787082 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1787124..1787438) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1787124..1787438) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1787136) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1787459..1787477) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1787466) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1787488..1787496) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1787499..1788110) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1787499..1788110) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1788188..1788364) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1788188..1788364) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1788192) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1788203) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1788207..1788226) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1788242..1788245) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1788378..1788396) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1788399) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1788401..1788622) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1788412..1788417) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1788422..1788427 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1788442..1788460 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1788444 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1788483..1788626 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1788483..1788626 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1788623..1789303) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1788623..1789303) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1788627..1789638 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1789330..1789349) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789336) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789363..1789372) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1789454..1789678) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1789454..1789678) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1789468) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1789719..1789738) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1789731) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1789765..1790043) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1789765..1790043) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1790040..1791455) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1790040..1791455) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1790711..1790714 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1790730..1790749 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1790735 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1791484..1792311) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1791484..1792311) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1792289..1793599) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1792289..1793599) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1793608..1794261) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1793608..1794261) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1794246..1794935) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1794246..1794935) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1794942..1796276) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1794942..1796276) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1796257..1796412) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1796257..1796412) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1796295..1796313) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1796311) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1796329..1796334) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1796406..1796639) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1796406..1796639) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1796413) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1796515..1796519 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1796528..1796542 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1796543 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1796544..1796563) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1796553) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1796578..1796587) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1796599..1797378) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1796599..1797378) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1797407..1798687) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1797407..1798687) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1798055..1798073) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798071) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798087..1798094) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1798655..1798673) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798665) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798689..1798694) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1798752..1799057) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1798752..1799057) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1798885) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1799081..1799100) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1799096) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1799114..1799123) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1799193..1799202 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1799216..1799235 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1799216 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1799237) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1799239..1799253) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1799262..1799266) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1799262..1799663 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1799262..1799663 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1799670..1800623 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1799670..1800623 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1800613 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1800694..1801842) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1800694..1801842) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1800711) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1801855..1801859 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1801868..1801887) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1801875..1801894 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1801877) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1801885 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1802146..1802154 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1802168..1802187 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1802171 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1802212..1803237 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1802212..1803237 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1802615 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1802617..1802621 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1802631..1802632 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1803229 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1803281..1803712) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1803281..1803712) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1803286) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1803713..1804246) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1803713..1804246) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1804250..1804256 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1804267..1804377 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1804267 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1804269..1804288 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1804274..1804293) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1804294) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1804309..1804310) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1804378..1804803 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1804378..1804803 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1804791 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1804836..1806067 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1804853..1806190) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1804853..1806190) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1806262..1806456) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1806262..1806456) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1806275) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1806469..1807032) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1806469..1807032) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1807042..1807809) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1807042..1807809) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1807833..1807852) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807850) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807863..1807870) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807887..1808468) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1807887..1808468) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1808469..1808584) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1808616..1808867) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1808616..1808867) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1808629) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1808890..1808909) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1808904) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1808953..1810221) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1808953..1810221) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1810255..1810274) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810274) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1810286..1810293) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1810428..1810447 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1810431 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1810470..1811465 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1810470..1811465 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1811486..1812127 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1811486..1812127 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1812128..1813229 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1812166..1812786) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1812166..1812786) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1812192) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1812787..1813293) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1812787..1813293) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1813290..1814084) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1813290..1814084) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1814168..1814701) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1814168..1814701) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1814173) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1814631..1814636 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1814647..1815593 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1814649 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1814653..1814671 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1814719..1815330) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1814719..1815330) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1815362..1815381) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815381) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815394..1815399) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1815550 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1815590..1816363) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1815590..1816363) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1815625) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1816405..1816839) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1816405..1816839) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1816417) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1816868..1816887) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1816879) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1816881..1816945) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1816901..1816908) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1816924) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1816946..1818622) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1816946..1818622) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1818623..1818813) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1818802..1818821) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1818813) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1818836..1818839) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1818911..1820044) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1818911..1820044) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1818927) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1820066..1820085) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1820069) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1820104..1820721) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1820104..1820721) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1820737..1821219) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1820737..1821219) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1821220..1821367) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1821358..1821376) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1821368) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1821387..1821395) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1821421..1821430 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1821443..1821458 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1821445..1821531 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1821445 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1821494..1821501 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1821516..1821535 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1821533 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1821562..1822467 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1821562..1822467 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1822502..1822521 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1822516 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1822517..1822697 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1822698..1823846 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1822698..1823846 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1822867..1823896) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1823842 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1823878..1823897) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1823896) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1823912..1823920) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1823927..1824073 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1823927..1824073 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1823966..1823973 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1823987..1824006 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1823998..1824088 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1823998 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1824089..1824289 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1824089..1824289 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1824304 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1824341..1824523) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1824341..1824523) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1824349..1824654 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1824358) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1824584..1824602) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1824616..1824622) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1824620) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1824630..1824636 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1824651..1824662 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1824656 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1824679..1824948 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1824679..1824948 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1824803 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1824931 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1824976..1825158) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1824976..1825158) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1824996) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1825151..1825831) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1825151..1825831) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1825832..1825969) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1825848..1825853 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1825866..1825885 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1825871 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1825914..1826603 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1825914..1826603 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1825967..1825983) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1825970) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1825971..1826360) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1826341..1826360) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826358) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826372..1826380) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1826603..1827001 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1826603..1827001 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1826994..1827000 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1827015..1827026 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1827026 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1827043..1827171 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1827043..1827171 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1827172..1828152 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1827179..1828069) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1827179..1828069) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1827216) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1828091..1828110) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828098) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828122..1828128) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1828126 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1828170..1828316) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1828170..1828316) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1828186) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1828340) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1828341..1828352) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1828367..1828373) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1828391..1828648) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1828391..1828648) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1828668..1828687) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828683) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828699..1828706) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1828713..1832294) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1828713..1832294) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1832295..1832366) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1832356..1832375) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1832366) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1832411..1832608) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1832454) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1832470..1832559) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1832470..1832559) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1832587..1832606) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1832608) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1832621..1832628) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1832630..1833136) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1832630..1833136) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1833140..1834237) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1833140..1834237) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1834255..1834266) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834258) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834281..1834287) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1834311..1835627) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1834311..1835627) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1834324) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1835624..1836208) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1835624..1836208) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1836297..1836397) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1836297..1836397) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1836304) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1836398..1836538) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1836539..1838044) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1836539..1838044) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1837980..1838080) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1838020) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1838032 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1838070..1838089) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838086) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838103..1838110) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1838156..1839148) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1838156..1839148) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1838174) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1839193..1839783) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1839193..1839783) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1839785..1840759) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1839785..1840759) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1840797..1841816) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1840797..1841816) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1841864..1841883) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1841874) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1841895..1841902) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1841937..1841944 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1841958..1842037 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1841958 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1841959..1841978 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1842038..1842865 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1842038..1842865 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1842867..1843631 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1842867..1843631 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1843620 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1843662) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1843672..1845597) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1843672..1845597) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1845628..1845647) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845632) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1845634..1845698) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1845662..1845666) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1845699..1845890) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1845699..1845890) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1845909..1845927) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845918) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1845920..1846225) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1845943..1845948) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1845957..1845963 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1845978..1845989 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1845987 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1846054..1846206 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1846054..1846206 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1846216 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1846259..1847416) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1846259..1847416) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1846270) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1847504..1847904) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1847504..1847904) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1847514) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1847901..1847920) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1847919) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1847935..1847941) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1847963..1848259) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1847963..1848259) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1848284..1848303) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1848294) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1848317..1848324) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1848337..1848966) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1848337..1848966) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1848932) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1848968..1849195) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1848968..1849195) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1849223..1849242) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1849238) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1849240..1849394) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1849256..1849264) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1849279..1849407) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1849279..1849407) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1849394) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1849396..1849507) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1849397..1849416) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1849432..1849436) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1849508..1850749) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1849508..1850749) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1850463..1850481) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1850472) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1850496..1850503) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1850765..1853014) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1850765..1853014) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1853030..1853049) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1853046) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1853063..1853069) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1853117..1853623) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1853117..1853623) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1853140) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1853667..1853686) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1853684) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1853700..1853707) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1853705..1853714 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1853728..1853747 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1853740 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1853761..1854180 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1853761..1854180 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1854181..1854331 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1854201..1854578) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1854201..1854578) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1854234) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1854576..1854721 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1854608..1854626) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1854627) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1854640..1854649) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1854722..1854741 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1854723 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1854766..1854954 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1854766..1854954 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1854970 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1854993..1855364) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1854993..1855364) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1855026) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1855376..1855395) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855389) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855408..1855413) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1855410..1855655) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1855410..1855655) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1855681..1855699) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855686) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855711..1855719) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1855805..1855811 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855826..1855837 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855833 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1855854..1855958 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1855854..1855958 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1855940 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1855983..1856945) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1855983..1856945) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1856113..1856122 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1856134..1856149 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1856134 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1856138..1856473 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1856444..1856448 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1856464..1856483 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1856475..1856985 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1856475 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1856946..1857402) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1856986..1857606 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1856986..1857606 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1857391..1857402) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857402) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1857417..1857423) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1857628..1860372 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1857628..1860372 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1860042) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1860358 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1860448..1860942) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1860448..1860942) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1860461) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1860939..1861598) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1860939..1861598) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1861617..1862315) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1861617..1862315) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1862316..1862407) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1862408..1863700) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1862408..1863700) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1863701..1863762) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1863762..1863781) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1863762) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1863796..1863803) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1863844..1865025) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1863844..1865025) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1863848) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1865048..1865533) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1865048..1865533) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1865481..1865500) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1865498) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1865513..1865520) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1865542..1865712) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1865542..1865712) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1865713..1865784) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1865746..1865752 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1865767..1865786) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1865767..1865778 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1865774..1865848 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1865774 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1865784) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1865786..1865854) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1865802..1865808) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1865818 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1865855..1868650) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1865855..1868650) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1866323..1866327 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1866324 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1866329..1866333 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1866980..1866995) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1866994) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1867008..1867017) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1868651..1868775) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1868776..1869159) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1868776..1869159) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1869161..1870021) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1869161..1870021) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1870023..1870856) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1870023..1870856) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1870857..1871064) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1871059..1871078) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1871064) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1871095..1871099) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1871102..1872079) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1871102..1872079) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1872064..1873257) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1872064..1873257) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1873262..1874395) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1873262..1874395) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1874392..1875102) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1874392..1875102) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1875095..1875508) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1875095..1875508) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1875524..1876327) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1875524..1876327) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1876339..1876674) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1876339..1876674) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1876694..1876713) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1876704) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1876727..1876734) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1876743..1876750 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1876759..1876778) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1876764..1876783 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1876770 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1876778) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1876814..1877686 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1876814..1877686 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1877728..1878522) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1877728..1878522) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1877753) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1878523..1878590) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1878591..1879148) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1878591..1879148) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1879149..1879228) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1879273) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1879295..1880062) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1879295..1880062) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1880097..1880771) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1880097..1880771) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1880773..1881276) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1880773..1881276) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1881285 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1881340..1881359) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1881340) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1881374..1881381) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1881419..1881865) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1881419..1881865) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1881868 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1881920..1882459) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1881920..1882459) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1881933) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1882492..1882510) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1882503) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1882522..1882530) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1882531..1883802) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1882531..1883802) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1883803..1883870) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1883867..1883886) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1883870) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1883900..1883907) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1883937..1883956) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1883943) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1883945..1884089) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1883967..1883974) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1884071..1884089) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1884089) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1884105..1884110) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1884138..1885424) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1884138..1885424) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1884161) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1885435..1886550) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1885435..1886550) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1886599..1887681) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1886599..1887681) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1887692..1888495) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1887692..1888495) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1888180..1888199) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1888197) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1888211..1888218) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1888488..1889690) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1888488..1889690) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1889671..1890318) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1889671..1890318) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1889765) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1889941..1889944) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1889941) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1890161) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1890323..1891075 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1890323..1891075) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1890323..1891075) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1890356..1890358) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1890359 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1890465,1890468) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890479,1890481) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890481,1890483) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890506,1890508) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890508,1890512) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890514,1890516) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890523,1890525) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890538,1890540) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890541,1890543) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890546,1890548) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890556,1890558) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890559,1890561) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890562,1890564) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890568,1890570) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890594,1890596) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890626,1890628) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890679,1890681) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890727,1890729) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890742,1890746) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890760,1890762) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890769,1890771) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890781,1890783) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890846,1890848) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890856,1890858) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890864,1890867) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890884,1890886) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890900,1890902) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890928,1890930) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890943,1890945) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890968,1890970) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1890985,1890987) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1891000,1891002) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1891068..1892084) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1891068..1892084) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1892056..1893603) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1892056..1893603) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1893682..1893813) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1893725) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1893804..1893823) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1893813) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1893819..1894202) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1893819..1894202) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1893838..1893845) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1894199..1895287) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1894199..1895287) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1894328..1894343) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1894341) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1894356..1894364) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1895287..1896459) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1895287..1896459) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1896494..1896513) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1896511) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1896526..1896533) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1896534..1897304) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1896534..1897304) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1897330..1897349) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1897347) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1897361..1897367) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1897379..1897540) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1897422) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1897541..1897990) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1897541..1897990) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1898033..1898052) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1898040) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1898065..1898072) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1898106..1899152) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1898106..1899152) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1899094..1899795) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1899094..1899795) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1899802..1900557) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1899802..1900557) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1900558..1900643) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1900632..1900651) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1900643) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1900662..1900669) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1900721..1900948) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1900721..1900948) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1900742) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1900970..1901542) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1900970..1901542) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1901571..1901590) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1901581) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1901583..1901666) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1901603..1901609) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1901711) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1901730..1902008) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1901730..1902008) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1902009..1902234) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1902216..1902235) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1902234) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1902252..1902257) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1902382..1903860) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1902382..1903860) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1902395) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1903861..1904022) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1904009..1904027) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1904034) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1904041..1904775) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1904041..1904775) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1904042..1904047) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1904067) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1904797..1905000) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1904797..1905000) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1905036..1905055) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905057) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905069..1905076) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1905122..1905321) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1905165) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1905296..1905315) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905321) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905329..1905338) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1905338..1906375) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1905338..1906375) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1906393..1907703) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1906393..1907703) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1907704..1907828) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1907814..1907833) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1907828) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1907848..1907851) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1907857..1908051) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1907857..1908051) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1908048..1908941) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1908048..1908941) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1908938..1909537) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1908938..1909537) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1909410..1909416 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1909425..1909608 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1909427 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1909430..1909441 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1909548..1909566) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1909567) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1909582..1909587) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1909615..1909746 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1909615..1909746 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1909734 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1909789..1910838) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1909789..1910838) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1909809) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1910713) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1910851..1911999) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1910851..1911999) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1911180..1911183 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1911207 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1911273 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1911977 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1912000..1912139) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1912138..1912157) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1912139) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1912141..1912231) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1912172..1912179) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1912232..1912906) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1912232..1912906) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1912907..1912984) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1912985..1913161) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1912985..1913161) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1913173..1913191) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913190) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1913206..1913212) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1913206..1913859) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1913206..1913859) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1913889..1913908) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913902) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1913924..1913928) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1913952..1915304) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1913952..1915304) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1913967) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1915339..1916256) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1915339..1916256) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1915727) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1915878..1915885) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1915881) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1916294..1916305) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916303) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1916319..1916325) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1916395..1917051) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1916395..1917051) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1916409) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1917076..1917095) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1917091) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1917171..1918145) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1917171..1918145) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1917179) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1917999..1918004 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1918020..1918038 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1918030..1918223 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1918030 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1918181 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1918254..1919537) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1918254..1919537) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1918257) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1918295..1918301 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1918313..1918317 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1918313 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1919580..1919599) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919601) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919614..1919621) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1919693..1920277) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1919693..1920277) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1919695) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1920278..1920359) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1920352..1920371) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1920359) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1920385..1920392) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1920436..1921215) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1920436..1921215) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1921241..1921256) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1921252) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1921268..1921277) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1921301..1921744) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1921301..1921744) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1921318) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1921807..1922529) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1921807..1922529) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1922088) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1922480..1923049) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1922480..1923049) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1922798..1922816) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1922814) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1922831..1922837) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1923068..1923814 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1923109..1924599) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1923109..1924599) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1924592..1925650) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1924592..1925650) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1924940..1924949 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1924960..1925750 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1924960 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1924962..1924981 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1925691..1925710) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925714) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925722..1925729) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1925728..1925734 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1925748..1925767 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1925752..1925821 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1925752 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1925801..1925808 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1925823..1925915 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1925823..1925842 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1925823 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1925916..1926164 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1925916..1926164 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1926148 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1926204..1926776) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1926204..1926776) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1926224) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1926768..1927075) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1926768..1927075) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1926777..1926881) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1927074..1927093) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927090) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927107..1927113) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1927202..1927209 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1927220 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1927224..1927243 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1927273..1928850 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1927273..1928850 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1928832 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1928893..1929660) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1928893..1929660) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1928908) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1929162..1929774 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1929687..1929706) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929700) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1929721..1929724) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1929734 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1929772..1930878) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1929772..1930878) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1929789) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1930814..1931398) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1930814..1931398) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1931192..1931197 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1931208 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1931212..1931216 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1931349..1931354 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1931366 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1931370..1931388 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1931406 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1931447..1931466) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1931451..1931558 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1931455) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931479..1931486) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1931514 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1931543..1931601) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1931574) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1931602..1933371) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1931602..1933371) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1931658) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1933368..1934090) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1933368..1934090) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1934091..1934170) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1934171..1935346) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1934171..1935346) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1935366..1936994) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1935366..1936994) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1936991..1937530) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1936991..1937530) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1937531..1937624) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1937625..1938359) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1937625..1938359) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1938368..1938387) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938391) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938402..1938406) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1938451..1938987) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1938451..1938987) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1938456..1938475) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938460) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938490..1938497) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1938992..1939582) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1938992..1939582) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1939570..1940718) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1939570..1940718) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1940740..1940758) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1940747) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1940773..1940778) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1940841..1941380) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1940841..1941380) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1940854) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1941389..1941406) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941404) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941421..1941426) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1941435..1942028) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1941435..1942028) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1942018..1942773) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1942018..1942773) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1942617..1942626 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1942639..1942658 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1942648 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1942819..1942838) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942834) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942852..1942859) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1942999..1943006 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1943017..1943036 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1943022 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1943054..1943578 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1943054..1943578 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1943592..1943966) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1943592..1943966) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1943608) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1944028..1944047) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1944040) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1944059..1944066) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1944079..1944543) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1944079..1944543) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1944414..1944418 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1944432..1944436 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1944435 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1944576..1945772) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1944576..1945772) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1945787..1946434) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1945787..1946434) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1946445..1947530) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1946445..1947530) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1947531..1947659) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1947660..1947804) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1947660..1947804) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1947821..1947840) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947831) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1947855..1947862) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1947924..1948268) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1947924..1948268) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1947939) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1948300..1948318) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948313) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1948327..1948332 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1948333..1948339) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1948347..1949269 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1948347 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1948348..1948366 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1948354..1948369) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948357) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1948359..1948425) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1948382..1948391) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1948420..1948428) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948425) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948442..1948450) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1948503..1949057) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1948503..1949057) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1948513) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1949083..1949102) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949101) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1949103..1949502) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1949114..1949120) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1949324..1949560 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1949324..1949560 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1949503..1949709) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1949503..1949709) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1949742..1949761) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1949764) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1949818..1950072) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1949818..1950072) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1949952..1949961 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949963..1950352) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1949963..1950352) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1949975..1951046 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1949975..1949994 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1949975 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1950330..1950533) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1950330..1950533) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1950942..1951058 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1950942..1951058 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1951009 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1951135..1951144 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1951157..1951176 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1951157 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1951199..1951411 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1951199..1951411 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1951405 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1951547) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1951547..1951978) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1951547..1951978) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1951979..1952065) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1952048..1952067) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952065) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952081..1952086) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1952115..1952124 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1952134..1952231 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1952134 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1952137..1952152 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1952232..1953104 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1952232..1953104 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1953011 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1953077 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1953134..1954453) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1953134..1954453) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1953154) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1954454..1954518) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1954514..1954533) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954518) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954548..1954555) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1954559..1955177) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1954559..1955177) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1955163,1955170) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1955164..1955169 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1955170..1955186) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1955187..1956356) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1955187..1956356) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1956385..1956396) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1956400) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1956410..1956416) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1956502) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1956511..1957326) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1956511..1957326) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1957339..1958523) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1957339..1958523) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1958572..1958591) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958590) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1958592..1958683) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1958607..1958614) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1958684..1959574) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1958684..1959574) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1959582..1959809) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1959582..1959809) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1959712..1959731) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959723) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959745..1959752) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1959802) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1959811..1959829) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1959839..1959857) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1959845..1959851) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1959852) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959874..1959879) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1959934) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1959934..1960383) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1959934..1960383) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1960407..1960426) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1960417) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1960419..1960495) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1960442..1960446) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1960496..1961140) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1960496..1961140) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1961171..1961189) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1961188) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1961204..1961209) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1961241..1961456) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1961241..1961456) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1961321) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1961556..1962875) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1961556..1962875) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1961563) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1962893..1964299) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1962893..1964299) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1964347..1964366) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1964356) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1964358..1964439) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1964381..1964388) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1964440..1965867) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1964440..1965867) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1965912..1966901) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1965912..1966901) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1966902..1966981) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1966963..1966982) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966981) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1966983..1967303) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1966997..1967004) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1967022..1967029 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1967042..1967061 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1967044 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1967083..1967433 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1967083..1967433 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1967305..1967441) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1967348) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1967442..1968605) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1967442..1968605) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1968602..1969159) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1968602..1969159) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1969089..1969189) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1969129) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1969173..1969178 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1969194..1969212 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1969196..1969210) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1969200 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1969207..1969381 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1969212..1969215) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1969215) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1969234..1969356 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1969234..1969356 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1969357..1969364 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1969378..1969397 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1969383 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1969419..1970339 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1969419..1970339 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1970328 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1970371..1970595) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1970371..1970595) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1970428) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1970618..1970637) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1970625) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1970652..1970659) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1970674..1970681 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970696..1970715 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970703 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1970757..1971674 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1970757..1971674 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1971649 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1971714..1971953) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1971714..1971953) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1971725) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1971966..1972289) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1971966..1972289) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1972032..1972051) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972033) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972065..1972072) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1972286..1973317) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1972286..1973317) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1972313..1972332) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1972320) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1972343..1972350) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1973310..1973654) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1973310..1973654) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1973664..1974134) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1973664..1974134) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1974135..1974211) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1974135 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1974186..1974205) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1974211) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1974213..1974319) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1974220..1974227) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1974320..1974658) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1974320..1974658) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1974655..1975893) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1974655..1975893) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1974817..1974818 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1974828 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1974883 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1975918..1975936) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1975927) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1975953..1975958) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1975998..1976001 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976016..1976035 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1976025 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1976059..1976265 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1976059..1976265 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1976748..1976751 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976766..1976785 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1976782 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1976814..1978046 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1976814..1978046 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1977893..1978255 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1977893..1978255 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1978072..1978251) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1978105) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1978252..1978638) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1978252..1978638) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1978642..1979601) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1978642..1979601) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1979602..1979672) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1979673..1981019) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1979673..1981019) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1981020..1981094) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1981095..1981874) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1981095..1981874) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1981880..1982839) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1981880..1982839) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1982861..1982880) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982880) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982895..1982902) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1982936..1982943 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1982957..1983243 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1982957 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1982959..1982978 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1982973..1983218 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1982973..1983218 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1983244..1984080 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1983244..1984080 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1984078 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1984121..1985764) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1984121..1985764) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1984133) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1985782..1985788 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1985795 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1985802..1985813 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1985820..1985839) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1985825) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1985871..1985878 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1985892..1985911 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1985894 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1985936..1986952 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1985936..1986952 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1986939 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1987001..1987010 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987023..1987038 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987027 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1987062..1987823 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1987062..1987823 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1987731 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1987819 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1987851..1988051) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1987867..1987992) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1987867..1987992) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1987894) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1987985..1988017) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1987985..1988017) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1988045..1988064) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1988051) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1988077..1988084) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1988099..1989022) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1988099..1989022) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(1989048..1989067) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1989061) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1989081..1989086) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1989160..1989167 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1989181..1989200 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1989183..1989248 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 1989183 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 1989249..1990718 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 1989249..1990718 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 1990701 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 1990726..1990765 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(1990738,1990741) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1990746,1990747) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(1990758,1990759) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 1990767 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1990841..1992250) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(1990841..1992250) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(1990858) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(1990931) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(1992314..1992332) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1992316) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1992360..1993604) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(1992360..1993604) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(1993605..1993879) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 1993625..1993632 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1993646..1993665 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1993646 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 1993677..1993964 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 1993677..1993964 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(1993861..1993880) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(1993881) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(1993896..1993899) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 1993995..1994822 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 1993995..1994822 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 1994639 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 1994815 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1994827..1995747) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(1994870) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1994940..1994946 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1994960..1994978 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1994969 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 1995002..1995730 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 1995002..1995730 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(1995771..1996886) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(1995771..1996886) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(1995792) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(1996904..1998427) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(1996904..1998427) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(1998010..1998029) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998032) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1998044..1998048) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998420..1998842) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(1998420..1998842) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 1998871..1998878 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1998892..1998911 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1998906..1999059 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 1998906 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 1999016 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(1999044..1999574) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(1999044..1999574) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 1999061..1999696 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(1999591..1999602) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999598) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999617..1999623) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999626..2000594) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(1999626..2000594) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(1999642) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2000665..2001387) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2000665..2001387) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2000676) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2001380..2002039) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2001380..2002039) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2002040..2002119) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2002120..2002887) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2002120..2002887) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2002937..2002956) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2002952) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2002971..2002978) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2003155..2003592) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2003155..2003592) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2003164) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2003616..2003635) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2003637) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2003650..2003657) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2003690..2003696 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2003709 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2003711..2003729 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2003753..2004646 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2003753..2004646 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2004679..2004686 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004702..2004721 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2004710 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2004747..2005916 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2004747..2005916 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2005899 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2005989..2006825 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2005989..2006825 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2006823 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2006887) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2006887..2008161) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2006887..2008161) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2008184..2009167) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2008184..2009167) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2009181..2010173) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2009181..2010173) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2010195..2011619) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2010195..2011619) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2011640..2012731) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2011640..2012731) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2012750..2013844) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2012750..2013844) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2013856..2014755) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2013856..2014755) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2014791..2014810) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2014796) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2014798..2014879) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2014880..2016958) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2014880..2016958) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2017018..2017037) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2017035) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2017045..2017052 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2017054..2017057) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2017066..2017085 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2017073 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2017111..2017347 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2017111..2017347 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2017338 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2017389..2018294) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2017389..2018294) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2017392) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2018312..2019730) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2018312..2019730) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2018607..2018626) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2018624) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2019745..2020863) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2019745..2020863) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2020897..2022036) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2020897..2022036) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2022064..2022927) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2022064..2022927) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2022952..2024133) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2022952..2024133) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2023713) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2023820..2023826) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2023823) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2024047..2024147) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2024087) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2024180..2024198) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2024198) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2024214..2024219) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2024260..2024991) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2024260..2024991) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2024267) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2025014..2025033) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025025) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2025048..2025051) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2025070..2025690) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2025070..2025690) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2025705..2025998) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2025705..2025998) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2026018..2026037) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2026024) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2026052..2026059) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2026254..2026261 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026275..2026294 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2026292..2026497 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2026292 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2026306..2026458 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2026306..2026458 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2026466..2026473 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2026488..2026507 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026499 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2026531..2027649 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2026531..2027649 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2027634 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2027676..2027846) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2027719) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2027830..2027845) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027846) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2027848..2027976) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2027857..2027866) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2027975..2027994) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027998) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2028008..2028016) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2028108) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2028114..2028917) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2028114..2028917) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2028960..2028978) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028966) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2028968..2029120) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2028989..2028997) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2029116..2029135) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2029128) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2029147..2029154) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2029162..2029163 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2029223..2030953) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2029223..2030953) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2029238) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2030990..2031439) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2030990..2031439) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2031440..2031525) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2031537..2032382) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2031537..2032382) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2031570) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2032379..2034280) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2032379..2034280) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2033488..2033494 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033509..2033520 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2033517 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2034281..2034409) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2034404..2034423) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034409) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034438..2034444) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2034455..2035345) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2034455..2035345) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2035335..2035589) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2035335..2035589) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2035586..2036932) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2035586..2036932) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2036933..2037069) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2037070..2037921) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2037070..2037921) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2037933..2038328) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2037933..2038328) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2038371..2038390) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2038390) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2038392..2038554) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2038592..2038999) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2038592..2038999) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2038599) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2039020..2040372) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2039020..2040372) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2039901..2039920) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2039908) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2039935..2039941) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2040384..2040863) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2040384..2040863) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2040922..2040941) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2040933) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2040955..2040962) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2041019..2041675) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2041019..2041675) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2041026) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2041676..2042365) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2041676..2042365) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2042358..2042978) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2042358..2042978) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2042684..2042702) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2042702) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2042718..2042723) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2042992..2044191) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2042992..2044191) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2044210..2044611) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2044210..2044611) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2044618..2044824) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2044618..2044824) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2044847..2045362) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2044847..2045362) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2045356..2046279) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2045356..2046279) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2046280..2046354) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2046355..2046636) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2046355..2046636) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2046656..2046674) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2046679) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2046690..2046695) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2046781..2047338) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2046781..2047338) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2046793) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2047363..2048424) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2047363..2048424) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2048421..2048867) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2048421..2048867) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2048916..2048935) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2048932) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2048948..2048955) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2048954..2049490) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2048954..2049490) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2049503..2049514) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2049512) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2049528..2049534) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2049560..2049566 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2049579 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2049581..2049599 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2049636..2049639 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2049654..2049673 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2049665 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2049717..2050673 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2049717..2050673 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2050713..2051108 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2050713..2051108 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2050991..2051091 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2051051 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2051094 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2051105..2051980) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2051105..2051980) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2052007..2052025) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052024) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2052041..2052046) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052106..2052534) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2052106..2052534) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2052133) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2052569..2052588) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052577) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2052604..2052608) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052634..2053470) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2052634..2053470) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2053494..2053513) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2053505) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2053507..2054051) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2053527..2053534) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2053551..2053556 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2053570..2053589 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2053570 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2053581..2053660 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2053661..2054041 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2053661..2054041 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2053977 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2054021 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2054076..2055542) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2054076..2055542) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2054096) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2055535..2056881) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2055535..2056881) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2056911..2057999) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2056911..2057999) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2058073..2058272) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2058073..2058272) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2058123) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2058273..2058343) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2058276..2058281 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2058297..2058315 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2058301 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2058311..2058440 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2058329..2058348) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2058343) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2058362..2058369) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2058441..2060114 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2058441..2060114 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2060135..2060929 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2060135..2060929 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2060465..2060466 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2060471 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2060953..2060956 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2060972..2060991 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2060973..2061111 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2060973 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2061112..2061285 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2061112..2061285 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2061270..2061274 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2061287..2061306 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2061287 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2061319..2061654 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2061319..2061654 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2061631 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2061721 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2061753) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2061770,2061777) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2061771..2061776 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2061846..2061852 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2061853 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2061866..2061877 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2061896..2062222 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2061896..2062222 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2062039..2062263) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2062082) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2062204 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2062264..2062443) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2062264..2062443) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2062462..2062480) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2062477) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2062495..2062501) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2062514..2062888) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2062514..2062888) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2062889..2063272) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2062889..2063272) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2063298..2063645) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2063298..2063645) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2063629..2064060) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2063629..2064060) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2064050..2064346) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2064050..2064346) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2064360..2065331) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2064360..2065331) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2065384..2066454) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2065384..2066454) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2066472..2066491) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2066488) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2066505..2066512) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2066637..2066865) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2066678) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2066866..2067819) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2066866..2067819) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2067843..2067862) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2067864) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2067876..2067882) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2067902..2067908 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2067923..2067941 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2067941 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2067962..2069290 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2067962..2069290 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2069291..2070265 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2069343..2070179) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2069343..2070179) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2070180..2070364) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2070266..2070336 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2070266..2070336 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2070403..2070783) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2070403..2070783) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2070409) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2070812..2070830) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2070831) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2070845..2070851) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2070870..2070875 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2070891..2070909 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2070900 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2070950..2070957 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2070972 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2070973..2070992 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2071015..2071260 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2071015..2071260 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2071157 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2071246 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2071291..2072046 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2071300..2071935) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2071300..2071935) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2071325) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2071957..2071976) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2071974) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2071990..2071997) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2072014..2072021 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2072036..2072055 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2072048 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2072068) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2072070..2072084) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2072092..2072096) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2072092..2072265 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2072092..2072265 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2072253 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2072297..2072611) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2072297..2072611) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2072298..2073365 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2072311) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2072614..2073675) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2072614..2073675) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2073737..2074867) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2073737..2074867) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2074875..2074893) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2074907) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2074909..2074914) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2074950..2076866) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2074950..2076866) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2074977) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2075982..2075988 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2076001..2077030 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2076001 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2076004..2076022 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2076867..2076933) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2076927..2076946) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2076933) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2076961..2076968) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2076983..2077948) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2076983..2077948) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2077959..2078174) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2077959..2078174) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2078175..2078283) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2078284..2079807) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2078284..2079807) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2079825..2079844) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079838) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2079859..2079866) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2079897..2080070) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2079897..2080070) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2079924) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2080086..2080097) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080098) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2080111..2080117) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2080137..2080700) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2080137..2080700) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2080701..2080784) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2080785..2080934) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2080785..2080934) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2080831) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2080971..2080990) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2080981) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2081006..2081009) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2081018..2082097) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2081018..2082097) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2082094..2082564) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2082094..2082564) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2082509..2082517 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2082531..2082539 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2082532..2082705 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2082533 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2082600..2082619) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082612) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082631..2082638) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2082677..2082681 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2082697..2082716 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2082707 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2082744..2083097 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2082744..2083097 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2083094..2083558 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2083094..2083558 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2083544 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2083587..2084369) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2083587..2084369) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2083598) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2084380..2085189) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2084380..2085189) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2085210..2086094) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2085210..2086094) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2086094..2087023) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2086094..2087023) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2087092..2087994) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2087092..2087994) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2088049) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2088057..2088073) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2088084..2088086) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2088103,2088105) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2088149..2090299) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2088149..2090299) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2088159) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2088893..2088911) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088901) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088927..2088933) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2089588..2089607) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2089605) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2089621..2089630) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2090349..2090368) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2090354) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2090384..2090388) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2090413..2091705) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2090413..2091705) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2091728..2091739) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091739) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091753..2091759) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091812..2092420) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2091812..2092420) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2091827) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2092472..2092491) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092483) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2092485..2092553) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2092506..2092513) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2092544..2092562) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092553) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092577..2092583) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092599..2093081) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2092599..2093081) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2093082..2093374) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2093124..2093130 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093145..2093164 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2093158 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2093191..2093958 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2093191..2093958 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2093372..2093390) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2093374) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2093376..2094312) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2093404..2093410) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2093959..2094389 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2094346 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2094357) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2094374..2094802) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2094374..2094802) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2094798..2094802 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2094812..2094826 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2094821 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2094825..2094844) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2094848) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2094859..2094866) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2095017..2095022 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2095038..2095056 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2095050 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2095079..2095378 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2095079..2095378 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2095391..2095398 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2095413..2095432 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2095424..2095500 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2095424 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2095501..2096634 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2095501..2096634 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2096615 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2096660..2097049) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2096660..2097049) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2096686) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2097080..2097091) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2097084) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2097105..2097111) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2097124..2097131 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2097142..2097161 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2097143 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2097182..2097763 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2097182..2097763 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2097761 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2097806..2098414 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2097806..2098243) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2097806..2098243) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2097810) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2098244..2098338) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2098334..2098353) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2098338) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2098368..2098375) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2098381..2099262) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2098381..2099262) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2099258..2099263 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2099279..2099297 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2099295 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2099300..2099319) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2099306) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2099308..2099635) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2099324..2099333 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2099340 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2099346..2099365 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2099378..2099632 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2099378..2099632 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2099619 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2099659..2100552) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2099659..2100552) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2099664..2100465 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2099680) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2100562..2101878) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2100562..2101878) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2101914..2101933) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101925) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101949..2101953) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2101982..2101991 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2102003 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2102005..2102024 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2102047..2102790 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2102047..2102790 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2102772 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2102794..2102801 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2102815..2102834 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2102817..2102912 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2102817 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2102913..2103857 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2102913..2103857 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2103828 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2103880..2105001) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2103880..2105001) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2103905) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2104994..2105644) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2104994..2105644) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2105645..2105753) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2105741..2105760) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105753) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2105755..2105868) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2105776..2105780) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2105901..2106263) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2105901..2106263) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2105913) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2106259..2106263 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106271..2106285 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2106292 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2106300..2106319) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106302) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2106304..2106425) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2106331..2106338) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2106414..2106433) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2106422..2106441 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2106425) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2106427..2106566) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2106428..2106532 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2106428 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2106447..2106453) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2106496..2106503 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106517..2106536 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2106534..2108683 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2106534 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2106592..2107707) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2106592..2107707) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2106611) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2107708..2107905) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2107906..2109717) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2107906..2109717) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2109312..2109318 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2109328 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2109330..2109349 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2109357..2109653 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2109357..2109653 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2109751..2110245) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2109751..2110245) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2110218..2110236) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2110229) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2110246..2110359) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2110248..2110256) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2110254..2110259 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110275..2110293 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2110290 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2110344..2110362) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2110359) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2110361..2110438) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2110378..2110383) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2110404..2110423) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2110438) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2110439..2110442) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2110499..2111311) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2110499..2111311) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2111337..2111975) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2111337..2111975) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2111976..2112107) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2112101..2112120) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2112108..2114147) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2112108..2114147) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2112110) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2112135..2112142) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2112154) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2112220) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2114140..2115027) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2114140..2115027) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2115110..2115284) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2115110..2115284) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2115144) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2115259..2115264 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2115280..2115298 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2115288..2115307) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2115290..2116702 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2115290 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2115300) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2115322..2115329) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2115324..2116091) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2115324..2116091) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2116128..2116271) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2116128..2116271) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2116272..2116418) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2116419..2117324) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2116419..2117324) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2117305..2117715) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2117305..2117715) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2117753..2117772) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2117764) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2117766..2117833) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2117787..2117790) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2117834..2118205) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2117834..2118205) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2118186..2118659) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2118186..2118659) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2118660..2120795) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2118660..2120795) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2120639..2120644 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2120659 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2120660..2120678 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2120874..2121833) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2120874..2121833) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2120889) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2121830..2123026) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2121830..2123026) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2121897..2121916) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2121902) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2121930..2121937) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2121977..2121995) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2121989) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2122010..2122016) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2122204) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2122218..2122229) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2122244..2122250) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2123045..2123326) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2123045..2123326) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2123383..2123802) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2123383..2123802) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2123397) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2123827..2124822) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2123827..2124822) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2124844..2126157) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2124844..2126157) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2126193..2126208) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2126210) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2126221..2126230) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2126288..2126734) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2126288..2126734) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2126301) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2126499) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2126749..2126922) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2126749..2126922) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2126858..2126862 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2126863 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2126983..2127002) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2126998) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127016..2127023) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2127041..2127046 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2127061 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2127062..2127080 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2127095..2128018 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2127095..2128018 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2128055..2129410) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2128055..2129410) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2128061) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2129410..2130180) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2129410..2130180) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2130203..2131138) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2130203..2131138) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2131163..2132290) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2131163..2132290) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2132207..2132210 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2132218 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2132291..2132468) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2132330..2132420 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2132330..2132420 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2132490..2134325) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2132490..2134325) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2132513) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2134349..2134912) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2134349..2134912) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2134913..2134983) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2134984..2136015) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2134984..2136015) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2136056..2136075) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2136069) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2136090..2136097) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2136096..2137235) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2136096..2137235) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2137108..2137119) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2137112) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2137133..2137139) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2137288..2139126) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2137288..2139126) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2137310) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2139161..2139180) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139178) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2139196..2139200) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139260..2139598) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2139260..2139598) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2139266) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2139615..2140820) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2139615..2140820) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2140840..2140858) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2140852) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2140874..2140879) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2140883..2141989) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2140883..2141989) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2142017..2142028) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142024) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142043..2142049) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2142088..2142091 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2142104 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2142107..2142126 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2142118..2142192 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2142193..2142459 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2142193..2142459 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2142448 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2142474..2143517) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2142474..2143517) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2142519) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2143546..2143565) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2143557..2143706) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2143557..2143706) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2143558) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143579..2143583) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2143581..2143920) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2143624) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2143693..2143699 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2143713..2143732 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2143714 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2143747..2143881 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2143747..2143881 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2143875 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2143921..2146251) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2143921..2146251) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2143938..2143957) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2143954) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2143971..2143980) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146255..2146824) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2146255..2146824) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2146851..2146870) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2146861) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2146885..2146892) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2146891..2147508) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2146891..2147508) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2147529..2147534 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2147546 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2147550..2147568 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2147569..2147583) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147571) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2147573..2148420) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2147592..2147596) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2147592..2148413 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2147592..2148413 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2148408..2148427) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2148414..2148494 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2148421) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2148441..2148448) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2148454 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2148479..2149222) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2148479..2149222) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2148509) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2149219..2149575) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2149219..2149575) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2149593..2150153) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2149593..2150153) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2150143..2150712) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2150143..2150712) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2150724..2151014) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2150724..2151014) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2151008..2151850) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2151008..2151850) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2151842 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2151868..2152968) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2151868..2152968) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2152972..2153490) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2152972..2153490) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2153400..2153417) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153414) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2153433..2153436) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2153491..2154052) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2153524) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2153715..2153722 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2153733..2153833 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2153733..2153752 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153733 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2153783..2154041) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2153783..2154041) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2153834..2153992 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2153834..2153992 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2153993..2154239 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2154040..2154059) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154051) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2154075..2154079) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2154103..2154250) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2154140) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2154196 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2154241..>2154318 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2154245..2154264) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2154250) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2154277..2154286) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2154318,2154320) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2154319 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2154320..2154762 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2154333..2154749) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2154333..2154749) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2154795..2156093) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2154795..2156093) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2156080..2156775) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2156080..2156775) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2156841..2156858) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2156850) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2156936..2156942 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2156949..2156967 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2156964 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2157043..2158260 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2157043..2158260 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2157502..2157509 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2157524..2157543 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2157540 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2158179..2158427 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2158179..2158427 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2158356..2159403) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2158772..2159329 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2158772..2159329 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2159330..2159452 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2159405..2159819) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2159448) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2159820..2160344) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2159820..2160344) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2160192..2160199 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2160210..2160229 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2160224 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2160345..2160432) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2160427..2160446) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160432) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2160434..>2160570) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2160461..2160468) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2160570,2160577) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2160571..2160576 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2160629..2161159) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2160629..2161159) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2161205..2161224) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2161228) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2161238..2161245) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2161294..2162274 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2161294..2162274 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2162548..2163864) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2162548..2163864) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2163865..2163978) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2163979..2164848) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2163979..2164848) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2164871..2164890) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164888) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164905..2164910) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2164955..2164956) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164963) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164993..2164994) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2164993..2166096 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2164993..2166096 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2165986..2166005 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2165992 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2166343) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2166369..2167202) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2166369..2167202) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2167232..2167251) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2167241) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2167407..2167411 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2167422..2167644 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2167422 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2167426..2167445 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2167645..2167908 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2167645..2167908 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2167896 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2168045..2168860 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2168045..2168860 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2169195..2169267) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2169238) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2169268..2169624) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2169268..2169624) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2169677..2170036) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2169677..2170036) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2170129..2170148) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2170139) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2170308..2170409) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2170308..2170409) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2170449..2170551) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2170491) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2170552..2170938) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2170552..2170938) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2170980..2170996) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2170996) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2171129..2171135 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171150..2171161 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171150 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2171187..2171432 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2171187..2171432 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2171450..2171818 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2171450..2171818 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2171837..2172973 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2171837..2172973 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2172992..2173189 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2172992..2173189 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2173205..2173504 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2173205..2173504 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2173495 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2173767..2174189) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2173767..2174189) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2174187..2174190 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2174206..2174225 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2174221..2174371 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2174221 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2174224..2174243) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2174231) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2174257..2174264) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2174340..2174359) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2174348) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2174372..2174566 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2174372..2174566 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2174374..2174381) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2174584..2174591 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2174607..2174626 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2174611 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2174612..2174696 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2174697..2175746 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2174697..2175746 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2175814..2175821 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175836..2175855 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2175849 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2175877..2176386 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2175877..2176386 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2176355 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2176400..2177505 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2176428..2178461) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2176428..2178461) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2176453) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2178370..2178537) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2178370..2178537) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2178462..2178617) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2178618..2179445) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2178618..2179445) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2179466..2180275) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2179466..2180275) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2180292..2180780) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2180292..2180780) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2180780..2181220) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2180780..2181220) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2181217 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2181257..2181275) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2181261) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2181410..2184217) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2181410..2184217) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2184433..2184452) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2184439) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2184764..2184904 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2184764..2184904 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2184885..2184904 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2184895 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2184943..2186331 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2184943..2186331 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2186320 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2186353..2186426) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2186395) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2186427..2187059) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2186427..2187059) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2186483) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2187113..2187132) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2187124) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2187138..2187144 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2187147..2187154) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187158..2187177 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187163 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2187212..2188039 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2187212..2188039 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2188035 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2188152..2188161 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2188174..2188189 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2188179 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2188235..2188735 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2188235..2188735 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2188735..2189592 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2188735..2189592 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2189610..2189621) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189629) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2189636..2189642) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2189703..2191607 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2189703..2191607 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2191688..2191694 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2191710..2191728 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2191716 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2191741..2192031 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2191741..2192031 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2192032..2192147 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2192129..2192136 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2192149..2192274 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2192149 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2192150..2192168 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2192168..2192268 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2192168..2192268 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2192231 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2192275..2195439) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2192275..2195439) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2192291) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2193425..2193434 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2193448..2193467 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2193469 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2195455..2196039) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2195455..2196039) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2196262..2196804) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2196262..2196804) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2196805..2196890) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2196888..2196903) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2196890) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2196916..2196925) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2196959..2197175) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2196993..2197151) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2196993..2197151) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2197002) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2197173..2197192) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2197175) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2197177..2197307) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2197206..2197215) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2197308..2197457) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2197308..2197457) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2197451 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2197458..2197548) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2197550..2197769) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2197593) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2197715 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2197748..2197767) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2197769) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2197771..2197846) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2197782..2197789) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2197847..2198647) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2197847..2198647) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2198716..2198869) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2198759) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2198860..2198879) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2198869) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2198894..2198900) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2198910..2199278) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2198910..2199278) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2199279..2199375) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2199361..2199380) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2199365..2199368 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2199381) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2199384..2199403 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2199386 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2199387..2199593 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2199396..2199400) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2199594..2202536 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2199594..2202536 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2202555..2203037 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2202555..2203037 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2203017 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2203073..2203303) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2203073..2203303) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2203093) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2203304..2203385) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2203386..2204525) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2203386..2204525) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2204527..2205450) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2204527..2205450) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2205443) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2205451..2205514) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2205515..2206210) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2205515..2206210) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2205950..2205969) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2205968) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2205982..2205991) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2206231..2206872) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2206231..2206872) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2206439..2206458) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206458) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2206475..2206478) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2206924..2206933 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2206930..2206949) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2206936) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2206946..2206965 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2206955..2207019 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2206955 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2206965..2206968) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2207000..2207007 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2207021 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2207023..2207040 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2207065..2207268 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2207065..2207268 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2207275 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2207305..2208006) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2207305..2208006) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2207317) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2208071..2209825) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2208071..2209825) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2208099..2208118) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2208109) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2209140..2209155) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209143) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2209168..2209177) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2209371..2209389) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209385) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2209404..2209411 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2209404..2209409) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2209426..2209445 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2209431 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2209879..2210352) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2209879..2210352) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2209886) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2210353..2210485) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2210467..2210486) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210485) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2210487..2210595) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2210500..2210507) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2210588..2210607) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210595) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2210603..2211238) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2210603..2211238) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2210623..2210627) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2210733..2210738 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2210754..2210772 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210761 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2211245..2212513) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2211245..2212513) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2212532..2213461) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2212532..2213461) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2213467..2214120) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2213467..2214120) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2214121..2214225) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2214207..2214226) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214225) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214242..2214246) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2214272..2215354) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2214272..2215354) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2214306) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2215370..2215389) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2215390) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2215404..2215407) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2215480) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2215485..2215766) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2215485..2215766) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2215545) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2215784..2216200) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2215784..2216200) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2216032..2216050) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216051) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2216066..2216071) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2216208..2216474) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2216208..2216474) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2216362..2216370 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2216385..2216404 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2216393..2217582 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2216393 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2216475..2216535) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2216529..2216548) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216535) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2216559..2219195) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2216559..2219195) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2216562..2216569) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2218961..2218979) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218977) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218993..2219000) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2219196..2219274) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2219275..2219482) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2219275..2219482) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2219490..2219509) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2219505) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2219524..2219531) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2219526..2220587) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2219526..2220587) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2220496..2220501 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2220507..2220742 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2220508 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2220517..2220535 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2220604..2220615) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220605) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220629..2220635) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2220743..2221471 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2220743..2221471 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2221199) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2221493..2222314 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2221493..2222314 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2222375..2223025 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2222375..2223025 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2223042..2223698 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2223042..2223698 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2223697 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2223733..2223864) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2223733..2223864) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2223751) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2223886..2224077) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2223886..2224077) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2224089..2224613) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2224089..2224613) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2224200) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2224204..2224215) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2224230..2224236) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2224584..2224595) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2224590) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2224610..2224616) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2224671..2227067) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2224671..2227067) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2224697) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2224917..2224923 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2224931 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2224938..2224949 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2224951..2225300 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2225052) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2227092..2227712) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2227092..2227712) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2227798..2228913) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2227798..2228913) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2227799) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2228944..2230083) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2228944..2230083) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2229650..2229669) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2229662) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2229683..2229690) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2230102..2230518) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2230102..2230518) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2230519..2230616) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2230601..2230620) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230616) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230636..2230639) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2230664..2230671 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2230685..2230704 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2230693 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2230721..2231986 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2230721..2231986 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2231985 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2232028..2232792) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2232028..2232792) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2232046) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2232876..2233076) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2232876..2233076) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2232894) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2233063 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2233064..2233073 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2233074..2233093) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2233085) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2233106..2233113) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2233128..2234906) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2233128..2234906) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2234920..2236194) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2234920..2236194) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2236284..2236516) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2236284..2236516) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2236314) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2236526..2236529 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2236540..2236559) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2236544..2236563 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2236546..2236830 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2236546 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2236559) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236574..2236581) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2236576..2236746) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2236576..2236746) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2236777..2236788) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2236794) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2236803..2236809) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2236806..2236813 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2236827..2236845 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2236832 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2236879..2238435 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2236879..2238435 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2238414 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2238462..2238860) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2238462..2238860) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2238470) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2238914..2241118) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2238914..2241118) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2241147..2241166) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241154) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2241156..2241246) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2241181..2241188) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2241210 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2241286..2241798) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2241286..2241798) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2241291) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2241804..2244164) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2241804..2244164) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2242268..2242287) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2242276) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2242301..2242310) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2244178..2244197) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244189) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2244212..2244218) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2244231..2244554) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2244231..2244554) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2244575..2244593) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2244586) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2244608..2244614) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2244630..2245127) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2244630..2245127) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2245128..2245203) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2245197..2245216) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2245203) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2245230..2245237) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2245285..2247498) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2245285..2247498) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2245290) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2247057..2247062 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2247076..2247095 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2247084 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2247537..2247833) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2247537..2247833) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2247744 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2247834..2247912) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2247874..2247879 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2247896..2247914 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2247898..2247917) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2247898 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2247912) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2247914..2248832) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2247932..2247935) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2247949..2249505 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2247949..2249505 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2248818..2248836) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2248832) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2248848..2248856) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2249506..2250270 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2249509..2250165) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2249509..2250165) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2250184..2250195) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2250196) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2250209..2250215) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2250248..2250253 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2250269..2250287 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2250272 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2250300..2250752 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2250300..2250752 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2250736 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2250791) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2250809..2251075) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2250809..2251075) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2251112..2252257) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2251112..2252257) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2251164) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2251208) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2251210..2251229) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2251244..2251249) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2252284..2253312) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2252284..2253312) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2253342..2253542) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2253342..2253542) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2253535..2254539) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2253535..2254539) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2254550..2255155) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2254550..2255155) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2255174..2255193) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255190) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2255192..2255293) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2255204..2255210) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255294..2255806) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2255294..2255806) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2255835..2255846) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2255850) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2255854..2257161) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2255854..2257161) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2255861..2255867) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2257115) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2257185..2257203) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2257200) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2257218..2257224) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2257232..2258257) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2257232..2258257) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2258294..2258313) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2258314) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2258328..2258335) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2258383..2258390 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258404..2258423 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2258412 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2258444..2258449 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2258458 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2258465..2258483 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2258495..2259142 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2258495..2259142 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2258817..2259150) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2259121 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2259152..2259349) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2259188..2259310) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2259188..2259310) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2259195) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2259358) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2259359..2259376) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2259383..2259390) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2259395..2259685 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2259395..2259685 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2259406..2259425 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2259406..2259553 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2259406 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2259692..2259832 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2259692..2259832 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2259821 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2259881..2259887 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2259895..2259995 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2259902..2259920 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2259903 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2259955 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2259996..2261450 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2259996..2261450 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2261451 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2261491..2262213) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2261491..2262213) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2261496..2261917 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2261507) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2262236..2262255) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262253) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2262269..2262276) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2262316..2262912) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2262316..2262912) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2262331) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2262955..2262966) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2262957) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2262959..2263023) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2262981..2262987) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2263060..2264223) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2263060..2264223) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2263068) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2264224..2264299) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2264275..2264293) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264299) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264309..2264314) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264340..2265446) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2264340..2265446) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2265022..2265040) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2265047) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2265056..2265061) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2265358 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2265359..2265362 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2265433..2266302) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2265433..2266302) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2265527 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2266256..2267851) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2266256..2267851) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2267879..2267886 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2267879..2267898) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2267900 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2267902..2267921 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267903) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267913..2267920) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2267954..2269141 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2267954..2269141 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2267955..2267974) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2267973) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2267989..2267998) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2268856..2268861 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2268870 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2268872..2268891 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2269101..2269643 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2269101..2269643 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2269626 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2269668..2270525) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2269668..2270525) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2269671..2270380 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2269688) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2270542..2270985) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2270542..2270985) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2271046..2272332) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2271046..2272332) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2272366..2272944) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2272366..2272944) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2272945..2273010) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2272995..2273014) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273010) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2273012..2273229) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2273022..2273144 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2273022..2273144 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2273028..2273035) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2273265..2273549) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2273265..2273549) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2273274) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2273562..2273900) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2273562..2273900) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2273903..2274211) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2273903..2274211) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2274225..2274300) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2274225..2274300) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2274312..2274331) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274332) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2274345..2274352) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274358..2275224) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2274358..2275224) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2275217..2276011) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2275217..2276011) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2276014 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2276020..2276120 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2276035..2276053) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2276046) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2276069..2276074) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2276080 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2276123 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2276158) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2276161..2276967) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2276161..2276967) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2276969..2277649) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2276969..2277649) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2277702..2278220) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2277702..2278220) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2278217..2279089) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2278217..2279089) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2279120..2280133) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2279120..2280133) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2280174) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2280186..2280204) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2280225..2280920) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2280225..2280920) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2280957..2281526) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2280957..2281526) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2281378..2281393) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281387) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281406..2281415) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2281565..2281584) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281581) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281598..2281604) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2281677) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2281679..2282677) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2281679..2282677) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2282724..2282743) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282732) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2282755..2282762) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2282800) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2282811..2283557) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2282811..2283557) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2283585..2283604) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2283592) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2283619..2283626) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2283697..2284989) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2283697..2284989) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2283702) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2284990..2285048) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2285049..2287691) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2285049..2287691) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2287692..2287750) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2287751..2287973) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2287751..2287973) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2287794) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2288002..2288021) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288014) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2288016..2288124) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2288036..2288041) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2288078..2288087 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2288100..2288119 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2288101 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2288117..2288131) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288124) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288139..2288143) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2288139..2288330 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2288139..2288330 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2288349..2289374) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2288349..2289374) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2288379) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2289407..2291134) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2289407..2291134) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2290736..2290739 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2290755..2290774 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2290761 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2291130..2291134 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2291143..2291157 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2291157 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2291172..2291190) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2291188) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2291206..2291211) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2291265..2292557) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2291265..2292557) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2291282) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2292587..2293561) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2292587..2293561) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2293558..2294346) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2293558..2294346) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2294336..2295280) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2294336..2295280) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2295313..2296143) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2295313..2296143) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2296151..2297518) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2296151..2297518) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2297582..2297601) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2297588) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2297590..2297679) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2297639..2297658 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2297647 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2297676..2297695) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2297679) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2297681..2298097) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2297706..2297714) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2297748..2298245 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2297748..2298245 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2298081..2298099) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2298097) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2298099..2298229) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2298115..2298121) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2298209..2298220) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2298229) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2298235..2298241) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2298267..2298854) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2298267..2298854) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2298295) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2298851..2301175) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2298851..2301175) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2301176..2301287) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2301272..2301291) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2301287) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2301305..2301312) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2301356..2303014) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2301356..2303014) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2301375) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2303058..2303076) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2303069) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2303092..2303097) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2303166..2304428) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2303166..2304428) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2303176) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2304429..2304518) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2304506..2304525) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2304518) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2304520..2304651) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2304537..2304544) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2304696) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2304700..2305974) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2304700..2305974) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2305975..2306164) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2306151..2306170) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2306164) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2306185..2306189) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2306202..2307206) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2306202..2307206) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2307231..2307250) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2307249) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2307262..2307269) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2307325..2307924) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2307325..2307924) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2307346) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2307937..2309355) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2307937..2309355) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2309244..2309248 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2309263..2309267 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2309263 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2309405..2310502) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2309405..2310502) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2310523..2312079) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2310523..2312079) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2310919..2310922 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2310935..2313376 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2310935 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2310937..2310956 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2312066..2313094) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2312066..2313094) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2313118..2313636) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2313118..2313636) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2313357..2313360 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2313376..2313380 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2313378 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2313633..2315357) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2313633..2315357) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2315358..2315478) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2315479..2315725) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2315479..2315725) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2315522) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2315726..2315852) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2315834..2315853) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2315852) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2315854..2315984) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2315868..2315875) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2315979..2315998) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2315988) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2316012..2316015) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2316110..2316119 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2316133..2316152 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2316135 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2316173..2316508 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2316173..2316508 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2316502 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2316589..2316596 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2316610..2316629 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2316612..2316676 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2316612 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2316677..2317132 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2316677..2317132 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2317240..2317246 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2317260..2317278 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2317267 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2317316..2318137 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2317316..2318137 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2318130 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2318194 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2318201..2318274) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2318201..2318274) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2318235) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2318311..2318330) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2318314) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2318344..2318351) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2318405..2318914) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2318405..2318914) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2318422) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2318930..2319526) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2318930..2319526) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2319539..2320276) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2319539..2320276) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2320358..2320377) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2320374) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2320387..2321487) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2320387..2321487) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2320392..2320397) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2320404) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2321510..2321528) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2321526) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2321543..2321548) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2321602..2322420) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2321602..2322420) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2321614) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2322428..2322868) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2322428..2322868) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2322911..2322930) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2322920) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2322922..2323064) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2322946..2322950) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2323109) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2323112..2323336) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2323112..2323336) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2323385 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2323387..2323405 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2323394..2323413) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2323414) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2323427..2323436) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2323452..2323895) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2323452..2323895) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2323956..2324717) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2323956..2324717) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2323964) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2324720..2326480) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2324720..2326480) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2326514..2327122) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2326514..2327122) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2326892..2326899 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2326912..2326931 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2326914 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2327123..2327218) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2327208..2327227) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2327218) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2327220..2327841) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2327242..2327249) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2327357..2327361 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2327371..2327471 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2327378..2327397 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2327387 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2327415..2327861 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2327415..2327861 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2327431 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2327849 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2327887) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2327905..2329131) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2327905..2328396) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2327905..2329131) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2327905..2328396) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2329245) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2329257..2329436) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2329257..2329436) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2329289) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2329461..2329480) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2329468) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2329493..2329500) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2329501..2331273) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2329501..2331273) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2331300..2331319) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2331314) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2331333..2331340) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2331403) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2331409..2331723) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2331409..2331723) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2331749..2331768) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331763) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2331765..2331974) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2331784..2331786) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2331868..2331978) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2331868..2331978) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2331964..2331982) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2331974) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2331997..2332003) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2332046..2333533) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2332046..2333533) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2333534..2333646) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2333627..2333646) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2333646) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2333661..2333668) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2333750..2334727) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2333750..2334727) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2333758) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2334763..2335536) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2334763..2335536) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2335551..2336327) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2335551..2336327) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2335616 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2336342..2336926) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2336342..2336926) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2336968..2336987) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2336968) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2337000..2337007) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2337031..2338713) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2337031..2338713) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2338742..2338761) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2338750) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2338838) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2338902..2339306) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2338902..2339306) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2338904) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2339321..2341678) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2339321..2341678) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2341699..2343411) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2341699..2343411) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2343412..2343484) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2343485..2344018) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2343485..2344018) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2344025..2344282) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2344025..2344282) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2344309..2344328) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344325) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344340..2344347) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2344365..2344384 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2344372 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2344416..2345357 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2344416..2345357 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2345089..2345108) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345104) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2345122..2345129) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2345340 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2345372) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2345393..2347807) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2345393..2347807) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2345416) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2347823..2348857) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2347823..2348857) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2348858..2349178) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2348939..2349145 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2348939..2349145 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2349168..2349432 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2349168 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2349173..2349192) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2349175..2349189 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2349178) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349207..2349210) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2349212..2349958) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2349212..2349958) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2349985..2350004) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2349991..2349997 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2349998) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2350011..2350022 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2350018..2350024) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2350025 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2350077..2350292 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2350077..2350292 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2350274..2351686) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2350303..2350310 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2350326..2350345 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2350334 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2350361..2351467 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2350361..2351467 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2351503..2351506 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2351522..2351541 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2351526 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2351570..2352982 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2351570..2352982 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2351672..2351691) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351686) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2351704..2351713) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2352979..2354313 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2352979..2354313 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2354012,2354014) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2354311 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2354350) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2354352..2354594) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2354352..2354594) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2354595..2354766) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2354654..2354824) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2354654..2354824) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2354767..2356563) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2354767..2356563) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2354869..2354887) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2354887) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2354899..2354907) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2356560 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2356588..2356607) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2356598) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2356622..2356628) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2356658..2356714) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2356682) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2356715..2358217) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2356715..2358217) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2358088) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2358192..2358292) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2358232) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2358236..2359081) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2358236..2359081) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2359082..2360023) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2359082..2360023) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2360059..2361360) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2360059..2361360) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2361391..2362575) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2361391..2362575) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2362572..2363390) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2362572..2363390) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2363368..2364057) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2363368..2364057) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2364074..2365756) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2364074..2365756) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2365770..2367260) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2365770..2367260) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2367353..2367372) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367360) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2367362..2367437) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2367387..2367394) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2367438..2368409) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2367438..2368409) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2368410..2368538) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2368523..2368542) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2368538) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2368557..2368560) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2368606..2369691) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2368606..2369691) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2368620) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2369717..2369736) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2369740) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2369751..2369758) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2369809..2369818 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2369824 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2369830..2369845 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2369875..2370267 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2369875..2370267 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2370238 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2370283..2370589 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2370283..2370552) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2370283..2370552) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2370299) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2370468) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2370546 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2370609..2370968) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2370609..2370968) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2370622) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2371000..2371200) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2371000..2371200) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2371213..2371734) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2371213..2371734) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2371796..2371935) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2371796..2371935) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2371932..2371951) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371942) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2371944..2372008) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2371965..2371972) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2371990..2372009) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2372008) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2372025..2372029) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2372127..2372134 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2372148..2372166 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2372148 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2372180..2372845 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2372180..2372845 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2372823 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2372877..2373572) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2372877..2373572) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2372899) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2372943) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2373594..2374034) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2373594..2374034) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2374056..2374075) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2374075) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2374091..2374094) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2374168..2374893) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2374168..2374893) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2374197) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2374871..2376652) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2374871..2376652) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2376736..2376739 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2376748..2376767) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2376753) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2376754..2376773 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2376761 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2376819..2377601 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2376819..2377601 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2377585 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2377635) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2377642..2379573) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2377642..2379573) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2379617..2379864) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2379617..2379864) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2379620..2379629) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379620) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2379675) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2379875..2379894) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2379888) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2379890..2379970) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2379910..2379914) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2379971..2380816) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2379971..2380816) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2380836..2380854) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2380842) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2380870..2380875) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2380895..2381536) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2380895..2381536) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2381570..2382505) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2381570..2382505) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2382533..2383951) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2382533..2383951) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2383980..2383999) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383988) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384014..2384017) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384066..2384524) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2384066..2384524) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2384085) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2384525..2384672) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2384663..2384682) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2384672) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2384674..2384752) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2384697..2384700) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2384797) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2384798..2385178) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2384798..2385178) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2385179..2385333) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2385313..2385332) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2385320 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2385321..2385340 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2385333) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385347..2385353) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2385411..2385422) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2385417..2386439) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2385417..2386439) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2385418) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385437..2385443) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2386483..2386502) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2386514) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2386515..2386522) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2386645..2387025) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2386645..2387025) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2386669) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2387026..2387156) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2387081..2387085 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387101..2387120 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2387102..2387208 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2387102 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2387146..2387165) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387156) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387180..2387187) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2387209..2388399 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2387209..2388399 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2388031..2388049) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2388047) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2388065..2388070) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2388423..2389265 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2388423..2389265 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2389038..2389043 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2389059..2389077 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2389060 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2389258 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2389298) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2389307..2389900) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2389307..2389900) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2389916..2390548) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2389916..2390548) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2390549..2390713) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2390714..2391544) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2390714..2391544) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2391567..2394209) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2391567..2394209) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2394264..2394283) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2394273) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2394297..2394304) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2394333..2394452) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2394376) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2394453..2396192) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2394453..2396192) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2396185..2396907) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2396185..2396907) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2396975..2396994) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2396985) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2396987..2397087) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2397008..2397014) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2397119..2398057) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2397119..2398057) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2397132) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2398101..2399372) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2398101..2399372) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2399157..2399176) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2399169) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2399373..2399455) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2399455) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2399457..2399535) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2399457..2399476) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2399492..2399496) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2399536..2400654) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2399536..2400654) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2400149 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2400496..2400499 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2400504 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2400633 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2400655..2400861) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2400829..2400841 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2400840 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2400847..2400866) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2400861) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2400881..2400885) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2400981) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2400988..2401452) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2400988..2401452) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2401465..2401484) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2401479) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2401481..2402666) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2401481..2401486 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2401497..2401505) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2401501..2401519 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2401507 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2401549..2402664 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2401549..2402664 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2402635 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2402697..2403080) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2402697..2403080) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2402711) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2403081..2403172) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2403173..2404930) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2403173..2404930) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2404973..2405932) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2404973..2405932) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2405933..2406034) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2406023..2406042) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406034) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2406058..2406062) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2406116..2407093) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2406116..2407093) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2406143) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2407078..2407950) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2407078..2407950) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2407912..2407917 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2407933..2407951 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2407937..2409111 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2407937 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2407951..2408034) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2408023..2408042) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408034) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2408036..2408188) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2408058..2408062) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2408190..2408284) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2408233) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2408285..2409517) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2408285..2409517) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2409518..2409634) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2409622..2409641) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2409634) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2409654..2413001) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2409654..2413001) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2409655..2409662) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2410666..2410675 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2410687..2410702 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2410687 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2410875..2410894) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2410894) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2410908..2410915) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2413032..2413051) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2413050) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2413065..2413072) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2413090..2413095 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2413107 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2413111..2413129 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2413141..2413482 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2413141..2413482 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2413479..2413982 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2413479..2413982 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2414015..2414018 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2414033..2414052 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2414033 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2414084..2414275 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2414084..2414275 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2414085) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2414251 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2414293..2415234) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2414293..2415234) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2414296..2414667 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2414328) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2414636..2414645 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2414659..2414678 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2414669..2415063 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2414669 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2415025..2415031 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2415047..2415066 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2415065..2415364 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2415065 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2415253..2415272) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2415269) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2415271..2415685) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2415287..2415290) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2415365..2415667 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2415365..2415667 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2415668..2417463 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2415686..2417005) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2415686..2417005) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2417031..2417050) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2417052) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2417065..2417070) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2417181..2418083) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2417181..2418083) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2418102..2419352) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2418102..2419352) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2419370..2420062) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2419370..2420062) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2420109..2421437) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2420109..2421437) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2421434..2421715) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2421434..2421715) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2421730..2422734) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2421730..2422734) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2422731..2423510) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2422731..2423510) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2423507..2424214) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2423507..2424214) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2424244..2424963) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2424244..2424963) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2424789..2424796 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424811..2424830 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424811 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2424985..2425797) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2424985..2425797) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2425811..2426620) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2425811..2426620) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2426634..2427170) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2426634..2427170) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2427207..2427214 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2427225..2427244) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2427228..2427247 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2427231..2427322 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2427231 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2427241) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2427258..2427265) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2427323..2428249 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2427323..2428249 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2427725..2428254) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2428299) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2428300..2428983) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2428300..2428983) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2428984..2429045) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2429046..2429813) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2429046..2429813) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2429858..2429877) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429880) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2429893..2429895) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2429940..2430176) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2429940..2430176) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2430025 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2430045) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2430136..2431521) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2430136..2431521) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2431518..2432729) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2431518..2432729) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2432730..2432807) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2432800..2432819) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2432806) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2432834..2432841) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2432899..2433411) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2432899..2433411) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2432917) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2433437..2433456) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2433445) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2433470..2433477) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2433496..2434683) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2433496..2434683) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2433511) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2434684..2434788) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2434773..2434792) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2434788) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2434790..2434919) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2434808..2434812) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2434856..2435059) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2434856..2435059) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2434917..2434928) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2434919) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2434943..2434949) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2435031..2436020) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2435031..2436020) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2435049) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2436081..2436584) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2436081..2436584) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2436087) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2436301..2436401 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2436361 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2436580 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2436607..2436626) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2436623) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2436640..2436647) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2436694..2437149) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2436694..2437149) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2436722) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2437163..2437843) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2437163..2437843) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2437255) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2437262..2437273) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2437288..2437294) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2437581) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2437856..2437874) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2437870) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2437889..2437894) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2437918..2438412) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2437918..2438412) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2437933) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2438425..2439432) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2438425..2439432) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2439456..2439471) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439473) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2439475..2439554) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2439483..2439492) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2439532..2439551 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2439542 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2439547..2439566) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2439551..2439617 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2439554) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439582..2439586) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2439618..2440421 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2439618..2440421 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2440351 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2440409 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2440453..2442042) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2440453..2442042) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2440462) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2442062..2443651) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2442062..2443651) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2443697..2443714) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443702) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2443730..2443736) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2443829) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2443830..2444039) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2443830..2444039) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2444035..2444039 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2444039 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2444048..2444062 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2444060..2444071) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2444071) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444086..2444092) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2444133..2445338) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2444133..2445338) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2445342..2446487) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2445342..2446487) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2446488..2447631) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2446574..2446581 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2446592..2446681 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2446592 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2446594..2446613 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2446682..2448019 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2446682..2448019 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2447617..2447636) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2447631) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2447651..2447658) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2447995 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2448114..2449802) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2448114..2449802) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2448115) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2449803..2449908) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2449885..2449893 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2449896..2449915) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2449904..2449923 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449908) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2449908 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2449909..2449998 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2449910..2450469) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2449931..2449933) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2449999..2450805 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2449999..2450805 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2450473..2450492) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450486) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450504..2450511) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2450755..2450801) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2450777) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2450802..2451425) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2450802..2451425) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2450806..2451148 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2451126..2451133 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451148..2451167 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2451150..2451293 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2451150 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2451265..2451269 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2451285..2451304 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2451295..2451425 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2451295 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2451427..2451551 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2451427 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2451441..2451459) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2451443..2451462 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2451459) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451470..2451478) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2451552..2452043 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2451552..2452043 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2452022 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2452081..2453820) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2452081..2453820) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2452099) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2453294..2453301 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2453315..2453333 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2453318 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2453320..2453915 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2453850..2453869) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2453858) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2453860..2454693) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2453896..2453903 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2453917..2454114 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2453917..2453936 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2453917 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2453974..2454106 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2453974..2454106 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2454115..2454717 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2454115..2454717 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2454640 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2454695..2454914) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2454703 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2454738) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2454750 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2454795..2454968 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2454910..2454928) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2454922) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2454926 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2454943..2454949) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2454988..2456256) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2454988..2456256) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2455014) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2456280..2456553) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2456280..2456553) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2456301..2456444) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2456344) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2456551..2456570) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2456563) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2456583..2456590) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2456598..2458316) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2456598..2458316) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2458330..2458337 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2458344..2458363) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2458352..2458371 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458358 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2458367) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2458377..2458383) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2458400..2458407 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458421..2458440 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458424 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2458477..2459109 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2458477..2459109 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2458682..2458690 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2458704..2458723 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2458710 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2459136..2459780 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2459136..2459780 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2459777..2460940 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2459777..2460940 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2460931 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2460951..2461679) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2460951..2461679) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2460987) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2461669..2462487) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2461669..2462487) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2462550..2463554) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2462550..2463554) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2462567) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2463589..2463608) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2463604) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2463606..2463714) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2463714..2463733) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2463714) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2463716..2463781) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2463747..2463753) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2463827) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2463830..2464906) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2463830..2464906) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2464947..2464966) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2464967) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2464969..2465069) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2464981..2464988) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2465003 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2465057..2465076) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465069) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2465090..2465096) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2465142..2465468) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2465142..2465468) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2465151) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2465492..2465947) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2465492..2465947) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2465978..2466400) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2465978..2466400) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2466421..2466439) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466434) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2466453..2466459) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2466473..2466491) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2466482) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2466502..2466510) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2466562..2467860) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2466562..2467860) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2466571) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2467885..2467904) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467886) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2467888..2468084) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2467917..2467926) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2468067..2468086) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2468084) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2468098..2468104) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2468110..2470968) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2468110..2470968) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2471002..2471021) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2471012) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2471037..2471041) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2471111) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2471128..2471733) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2471128..2471733) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2471749..2472558) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2471749..2472558) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2472573..2472896) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2472573..2472896) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2472897..2473035) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2472935..2473051) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2472935..2473051) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2473022..2473041) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2473035) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2473043..2473050 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2473065..2473084 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2473070 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2473131..2473577 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2473131..2473577 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2473578..2474306 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2473632..2474705) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2473632..2474705) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2473651) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2474727..2474746) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2474731) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2474760..2474767) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2474802..2474805 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2474820..2474839 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2474825 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2474864..2475181 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2474864..2475181 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2475181 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2475234..2476934) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2475234..2476934) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2475253) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2476966..2476984) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476973) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476999..2477005) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2477016..2477786) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2477016..2477786) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2477787..2477875) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2477873..2477892) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477875) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2477908..2477912) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2477932..2478573) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2477932..2478573) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2477942) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2478007) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2478599..2478618) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2478608) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2478610..2479058) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2478634..2478638) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2478717..2478723 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2478738..2478749 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2478745 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2478780..2479058 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2478780..2479058 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2479059..2479229 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2479059..2479673) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2479059..2479673) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2479207 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2479674..2480009) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2480001..2480020) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2480009) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2480035..2480042) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2480036..2482192) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2480036..2482192) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2481733,2481735) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2482218..2483147) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2482218..2483147) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2483196..2484110) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2483196..2484110) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2483873..2483891) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2483881) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2483905..2483911) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2484136..2484687) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2484136..2484687) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2484550..2484569 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2484553 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2484710..2484729) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2484722) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2484745..2484748) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2484770..2484777 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484788..2484807 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2484791..2484802) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2484795 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2484805) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2484816..2484822) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2484836..2485771 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2484836..2485771 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2485747 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2485805..2487196) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2485805..2487196) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2485817) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2487197..2487637) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2487223..2487228 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2487242..2487261 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2487255 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2487293..2488591 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2487293..2488591 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2487614..2487633) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2487637) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2487648..2487654) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2488578 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2488631..2489788) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2488631..2489788) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2488656) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2488904..2488909 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2488924..2488942 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2488932 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2489785..2490495) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2489785..2490495) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2490509..2490524) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2490526) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2490536..2490545) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2490552..2490553 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2490565..2490670 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2490565 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2490573..2490583 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2490636..2490642 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490657..2490676 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2490672..2490785 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2490672 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2490786..2491007 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2490786..2491007 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2490990 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2491059 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2491128..2491847) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2491128..2491847) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2491142) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2491913) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2491916..2493550) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2491916..2493550) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2493582..2493601) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2493598) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2493668..2493672 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2493688..2493707 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2493706 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2493752..2495014 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2493752..2495014 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2495015..2495113 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2495087..2495093 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2495109..2495127 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2495115..2495202 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2495115 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2495203..2496741 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2495203..2496741 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2496721 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2496778..2496960) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2496778..2496960) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2496797) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2496975..2496993) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2496995) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2497009..2497014) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2497028..2497696) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2497028..2497696) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2497718..2499004) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2497718..2499004) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2499016..2499519) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2499016..2499519) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2499516..2500637) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2499516..2500637) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2500645..2501610) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2500645..2501610) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2501636) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2501637..2501656) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2501671..2501678) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2501766..2501773 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2501786 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2501789..2501808 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2501826..2504144 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2501826..2504144 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2504134 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2504185..2505681) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2504185..2505681) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2504187) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2505706..2506566) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2505706..2506566) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2506642..2506661) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2506651) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2506677..2506684) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2506773..2507534) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2506773..2507534) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2506802) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2507535..2507610) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2507611..2508798) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2507611..2508798) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2508867..2509874) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2508867..2509874) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2509877..2510572) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2509877..2510572) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2510569..2511738) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2510569..2511738) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2510605..2510612 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2510627..2510646 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2510645 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2511728..2513074) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2511728..2513074) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2512144..2512148 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2512163 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2512164..2512182 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2513064..2513840) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2513064..2513840) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2513841..2513933) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2513919..2513938) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2513933) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2513953..2513960) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2514050..2514949) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2514050..2514949) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2514972..2514990) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514989) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2515001..2515009) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2515079..2515086 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2515102..2515121 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2515108 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2515167..2516201 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2515167..2516201 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2516150..2516157 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2516172..2516180 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2516189 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2516235..2517515 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2516235..2517515 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2517508..2518419 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2517508..2518419 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2518416..2519246 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2518416..2519246 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2519219..2519223 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2519239..2519258 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2519247 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2519266..2520564 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2519266..2520564 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2520545 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2520586..2520897) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2520586..2520897) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2520597) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2520921..2520940) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520929) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2520955..2520962) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2520963 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2521014..2523428) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2521014..2523428) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2521018) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2523429..2523524) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2523538..2523752) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2523538..2523752) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2523569) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2523764..2523783) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2523785) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2523789..2523794 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2523798..2523803) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523810..2523828 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2523823..2524263 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2523823 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2523855..2524190) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2523855..2524190) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2524185..2524449) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2524434..2524453) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2524449) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2524468..2524475) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2524488..2524495 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2524509..2524528 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2524525 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2524527..2524594 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2524595..2525380 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2524595..2525380 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2525381..2525437 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2525617..2526810) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2525617..2526810) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2525637) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2526811..2526909) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2526890..2526909) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526909) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2526923..2526930) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2526947..2526950 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2526965..2526984 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2526969 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2526999..2527745 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2526999..2527745 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2527640 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2527739 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2527782..2529722) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2527782..2529722) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2527793) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2529712..2530473) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2529712..2530473) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2530497..2530515) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2530516) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2530575..2531579) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2530575..2531579) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2530614) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2531572..2532267) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2531572..2532267) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2532291..2532309) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532303) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532325..2532328) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2532364..2533674) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2532364..2533674) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2532386) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2533664..2534359) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2533664..2534359) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2534374..2535351) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2534374..2535351) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2535381..2536367) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2535381..2536367) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2536237..2536246 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2536253 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2536259..2536274 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2536361..2537239) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2536361..2537239) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2537232..2537624) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2537232..2537624) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2537625..2537869) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2537658..2537795) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2537658..2537795) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2537793 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2537864..2537883) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537869) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2537897..2537904) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2537950..2538222) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2537950..2538222) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2537957) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2538262..2538273) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2538266..2538274 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2538266) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2538277 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538288..2538294) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538288..2538306 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2538317..2538322 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538336..2538355 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2538343 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2538384..2539352 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2538384..2539352 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2539349..2539933 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2539349..2539933 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2539897 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2539923..>2540054) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2539923..>2540054) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2539964) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2540057..2540058 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2540058..2540073) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2540064..2540083) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2540073) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2540075..2540209) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2540095..2540102) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2540184..2540203) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2540209) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2540302..2541693) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2540302..2541693) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2540310) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2541694..2541828) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2541829..2543727) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2541829..2543727) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2542885..2542891 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2542906..2542917 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2542918 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2543728..2543851) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2543877..2545079) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2543877..2545079) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2543896) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2545122..2545133) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2545128) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2545130..2545246) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2545147..2545153) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2545247..2545385) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2545247..2545385) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2545345 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2545394..2545413) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2545409) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2545430..2545434) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2545506..2545513 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2545525 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2545527..2545546 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2545582..2547165 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2545582..2547165 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2547154 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2547204..2547446) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2547204..2547446) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2547218) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2547498..2548271) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2547498..2548271) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2548272..2548362) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2548338..2548347 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2548351..2548370) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2548359 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2548360..2548379 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2548364) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2548385..2548392) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2548422..2549426 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2548422..2549426 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2549439..2550221 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2549439..2550221 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2549443..2550991) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2550196..2551008 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2550196..2551008 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2550993 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2551035..2551511) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2551035..2551511) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2551036) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2551541..2551560) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2551554) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2551556..2551690) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2551690) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2551692..2551703) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2551718..2551724) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2551720..2552124) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2551720..2552124) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2552152..2552171) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552169) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2552171..2552257) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2552184..2552193) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2552290..2552727) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2552290..2552727) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2552302) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2552744..2552762) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2552762) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2552764..2552989) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2552777..2552783) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2552819..2552838 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2552820..2552996 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2552820..2552996 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2552821 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2552990..2553427) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2552990..2553427) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2553016 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2553446..2553465) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2553467) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2553476..2553484) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2553547..2554020) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2553547..2554020) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2553556) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2553643) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2554021..2554372) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2554092..2554099 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554112..2554131 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554117 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2554149..2554376 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2554149..2554376 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2554373..2554936) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2554373..2554936) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2554961..2554980) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2554976) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2555030..2555278) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2555030..2555278) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2555051) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2555306..2555325) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2555339..2555346) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2555343) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2555405..2555411 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2555425..2555436 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2555437 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2555483..2556814 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2555483..2556814 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2556858..2557898 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2556858..2557898 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2557892..2557898 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2557913..2557924 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2557923 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2557952..2558110 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2557952..2558110 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2558099 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2558129..2559016) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2558129..2559016) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2558152) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2559006..2560313) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2559006..2560313) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2560319..2561071) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2560319..2561071) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2561090..2562010) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2561090..2562010) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2562046..2562057) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2562047) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562049..2562140) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2562071..2562077) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2562125 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2562126..2562145) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2562128..2562140 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2562140) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562142..2562223) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2562160..2562167) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2562223) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2562232..2562251) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2562265..2562272) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2562290..2563405) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2562290..2563405) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2562333) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2563402..2564862) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2563402..2564862) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2564305..2564323) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564309) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2564338..2564344) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2564951) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2564953..2565768) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2564953..2565768) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2565803..2566627) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2565803..2566627) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2565885..2565904) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2565885) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2565920..2565923) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2566051) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2566061..2566072) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2566087..2566093) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2566615..2568357) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2566615..2568357) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2568354..2569769) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2568354..2569769) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2569770..2569882) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2569862..2569881) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2569882) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2569884..2570034) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2569897..2569900) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2569995..2570001 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2570015..2570034) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2570015..2570026 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2570023 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2570034) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2570048..2570057) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2570059..2570778 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2570059..2570778 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2570129..2570786) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2570767 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2570787..2571605) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2570787..2571605) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2571626..2571645) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2571640) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2571660..2571668) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2571706..2571714 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2571727..2571746 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2571728 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2571777..2573063 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2571777..2573063 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2573060..2574010 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2573060..2574010 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2574013..2575236 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2574013..2575236 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2575160) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2575237..2575804 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2575310..2575741) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2575310..2575741) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2575336) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2575743..2576798) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2575743..2576798) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2576813..2577946) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2576813..2577946) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2577979..2577998) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577998) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2578011..2578020) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2578084..2578093 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2578107..2578126 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2578109 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2578136..2579209 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2578136..2579209 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2578433..2578439 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2578450 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2578453..2578464 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2579198 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2579236..2579242 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2579257 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2579258..2579276 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2579289..2579756 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2579289..2579756 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2579728 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2579787..2582183) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2579787..2582183) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2579802) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2582170..2583624) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2582170..2583624) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2583621..2584652) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2583621..2584652) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2584676..2585818) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2584676..2585818) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2585815..2587698) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2585815..2587698) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2586524..2587943 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2587730..2587745) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587743) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587760..2587765) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2587810) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2587931..2588002) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2587931..2588002) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2588028..2588118) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2588028..2588118) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2588122..2588196) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2588122..2588196) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2588207..2588283) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2588207..2588283) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2588299..2588372) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2588299..2588372) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2588383..2588458) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2588383..2588458) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2588476..2588551) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2588476..2588551) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2588564..2588640) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2588564..2588640) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2588652..2588728) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2588652..2588728) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2588746..2588838) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2588746..2588838) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2588845..2588921) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2588845..2588921) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2588924..2589000) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2588924..2589000) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2589020..2589092) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2589020..2589092) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2589098..2589174) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2589098..2589174) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2589190..2589266) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2589190..2589266) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2589276..2589361) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2589276..2589361) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2589376..2589450) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2589376..2589450) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2589456..2589542) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2589456..2589542) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2589553..2589628) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2589553..2589628) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2589666..2589741) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2589666..2589741) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2589774..2589849) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2589774..2589849) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2589870..2589987) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2589870..2589987) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2590043..2592970) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2590043..2592970) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2593138..2594692) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2593138..2594692) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2594494,2594496) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2594693..2594984) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2594820..2594828 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2594826 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2594936 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2594957..2594976) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2594984) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2594986..2595952) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2594990..2594997) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2595109..2595112 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2595124 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2595127..2595146 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2595157..2595258 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2595157..2595258 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2595257 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2595358..2595936 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2595358..2595936 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2595926 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2595978..2596499) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2595978..2596499) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2595996) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2596068) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2596517..2598046) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2596517..2598046) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2598067..2598591) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2598067..2598591) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2598635..2598650) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2598641) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2598643..2598730) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2598662..2598671) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2598715..2598733) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2598725 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2598729..2598748 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2598730) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2598748..2598753) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2598759..2599247 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2598759..2599247 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2599224 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2599253..2599831) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2599253..2599831) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2599269..2599660 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2599280) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2599865..2599884) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599874) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599898..2599905) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2599919..2601127) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2599919..2601127) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2599940) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2600896..2600915) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600908) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2600930..2600937) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2601144..2602616) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2601144..2602616) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2602667..2602686) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2602668) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2602701..2602708) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2602728..2602734 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2602748..2602767 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2602763 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2602815..2603357 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2602815..2603357 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2603340 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2603434..2603441 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2603454..2603554 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2603454 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2603456..2603475 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2603555..2604100 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2603555..2604100 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2604087 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2604192..2604199 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2604213..2604232 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2604220 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2604225..2604393 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2604225..2604393 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2604374 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2604466..2605134 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2604466..2605134 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2605141..2606478 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2605141..2606478 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2606464 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2606514..2606777) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2606514..2606777) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2606532) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2606817..2606836) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606819) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606849..2606856) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606886..2607734) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2606886..2607734) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2607779..2607798) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2607789) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2607813..2607820) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2607895..2609430) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2607895..2609430) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2607904) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2609088..2609188 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2609148 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2609214 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2609431..2609598) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2609587..2609606) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2609598) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2609600..2610477) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2609621..2609628) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2609840..2609849 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2609863..2609882 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609863 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2609915..2610400 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2609915..2610400 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2610401..2610687 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2610507..2610579) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2610507..2610579) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2610522) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2610566) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2610590..2610609) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2610610) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2610624..2610627) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2610644 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2610687..2611517) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2610687..2611517) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2610698) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2611518..2611609) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2611610..2612776) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2611610..2612776) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2612772..2612776 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2612784..2612798 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2612800..2612819) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2612800 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2612819) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2612833..2612840) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2612898..2612905 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2612911 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2612916..2612935 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2612958..2613944 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2612958..2613944 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2613915 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2613985..2615259) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2613985..2615259) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2613998) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2615285..2615599) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2615285..2615599) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2615617..2617074) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2615617..2617074) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2617079..2617855) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2617079..2617855) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2617889..2617908) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2617905) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2617912..2619981) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2617912..2619981) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2620014..2620033) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620026) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620047..2620053) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2620119..2622107) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2620119..2622107) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2620138) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2622111..2622118 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2622128..2622146) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2622134..2622153 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2622141) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2622150 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2622160..2622167) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2622216 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2622221..2624206) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2622221..2624206) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2622226) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2624227..2624245) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2624242) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2624244..2624331) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2624259..2624266) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2624332..2626320) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2624332..2626320) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2626345..2626363) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2626360) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2626377..2626384) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2626497..2628485) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2626497..2628485) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2626516) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2628506..2628524) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2628527) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2628537..2628544) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2628587..2628596 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2628610..2628629 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2628613 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2628643..2629380 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2628643..2629380 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2628668..2628687) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2628676) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2628703..2628707) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2629381..2632201 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2629394..2629648) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2629394..2629648) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2629420) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2629649..2629905) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2629906..2630304) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2629906..2630304) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2630264..2630398) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2630264..2630398) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2630347..2630366) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2630354) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2630381..2630387) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2630424..2632088) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2630424..2632088) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2630440) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2631396..2631415) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631401) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2631429..2631436) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2632113..2632131) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2632130) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2632147..2632152) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2632215..2633504) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2632215..2633504) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2632224) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2633033..2633039 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2633053..2633071 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2633059 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2633063..2633715 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2633548..2634225) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2633548..2634225) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2633558) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2633900..2634576 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2634260..2634279) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2634267..2634530) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2634267..2634530) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2634281) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634293..2634300) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2634542..2634560) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634556) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2634576..2634581) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2634577..2634909 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2634577..2634909 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2634594..2634600 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2634615..2634632 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2634626 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2634906..2635892 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2634906..2635892 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2635867) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2635889..2636293) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2635889..2636293) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2636294..2636352) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2636353..2636724) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2636353..2636724) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2636783..2638135) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2636783..2638135) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2636794) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2636950..2636968) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2636967) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2636984..2636989) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2638108) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2638111..2638122) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2638167..2638186) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638173) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2638175..2638246) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2638201..2638204) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2638247..2639419) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2638247..2639419) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2638582..2639503 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2639452..2639471) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2639465) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2639488..2639491) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2639523..2640686) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2639523..2640686) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2639538) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2640701..2640720) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2640719) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2640721..2640876) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2640735..2640742) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2640772..2640778 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640793..2640811 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640803 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2640804..2640862 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2640849..2640855 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2640851..2640862) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2640864 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2640869..2640880 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2640876..2640882) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2640876) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640878..2641189) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2640916..2641152 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2640916..2641152 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2641112 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2641178 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2641230..2641622) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2641230..2641622) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2641234) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2641664..2641683) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2641671) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2641673..2641823) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2641699..2641703) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2641726..2641732 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2641739..2642723 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2641739 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2641747..2641765 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2641824..2642984) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2641824..2642984) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2642876..2642882 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2642894 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2642896..2642900 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2642985..2643485) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2642985..2643485) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2643515..2643534) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2643521..2643527 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2643536) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2643542..2643553 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643542 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643545..2643552) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2643554..2643632 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2643633..2644454 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2643633..2644454 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2644434 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2644481) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2644483..2644743) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2644483..2644743) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2644733..2644736 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2644751..2644770 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2644763 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2644764..2644829 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2644769..2644788) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2644774) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2644800..2644806) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2644830..2645993 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2644830..2645993 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2646056..2646062 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646074..2646093 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646084 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2646119..2647405 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2646119..2647405 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2647121..2647863) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2647400..2647407 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647421..2647440 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2647422 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2647451..2647837 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2647451..2647837 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2647819 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2647864..2648481) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2647864..2648481) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2648516..2648534) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648533) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2648535..2650623) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2648549..2648554) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2648597..2648600 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2648615..2648634 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2648626 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2648692..2649870 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2648692..2649870 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2649908..2649914 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2649926..2649945 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2649931 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2649963..2651837 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2649963..2651837 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2650603..2650622) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2650623) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2650636..2650645) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2651858..2652271 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2651858..2652271 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2652263 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2652474..2653031) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2652474..2653031) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2652495..2652514 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2652505 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2652515) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2652527..2653208 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2653057..2653076) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2653065) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2653092..2653096) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2653209..2654810 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2653209..2654810 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2654803..2655510 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2654803..2655510 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2655495 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2655674..2655681 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2655692..2655981 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2655692 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2655696..2655715 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2655982..2657061 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2655982..2657061 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2657137..2658669 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2657137..2658669 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2658662..2659708 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2658662..2659708 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2659709..2660668 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2659709..2660668 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2660669..2660790 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2660763..2660766 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2660781..2660800 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2660792 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2660822..2662168 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2660822..2662168 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2662151 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2662204..2662419) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2662204..2662419) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2662359..2662365 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662379..2662390 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662383 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2662430..2662448) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662437) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2662462..2662469 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2662464..2662469) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2662484..2662579 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2662484..2662503 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2662484 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2662542..2662546 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2662562..2662581 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2662581..2662730 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2662581 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2662650..2665055 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2662650..2665055 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2665048..2665479 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2665048..2665479 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2665479..2665820 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2665479..2665820 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2665711..2665811 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2665771 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2665813..2667294 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2665813..2667294 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2666546..2668414) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2667300..2667776 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2667300..2667776 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2667776..2668060 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2667776..2668060 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2668044..2668418 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2668044..2668418 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2668389 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2668457..2668837) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2668457..2668837) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2668459) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2668856..2669500) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2668856..2669500) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2669501..2669580) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2669581..2671890) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2669581..2671890) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2670575..2670582 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2670596..2670615 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2670611 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2671484..2672455 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2671484 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2671496..2671512 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2671905..2672072) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2671905..2672072) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2672060..2672958) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2672060..2672958) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2672959..2673072) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2673066..2673085) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673072) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673099..2673105) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2673143..2673283) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2673143..2673283) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2673172) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2673284..2673370) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2673354..2673373) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673370) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673387..2673393) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2673470..2673488) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673480) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2673503..2673509) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2673505..2673630 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2673505..2673630 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2673658..2674087) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2673683..2673688 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2673700) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2673703..2673721 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2673705 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2673744..2674112 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2673744..2674112 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2674088..2675317) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2674088..2675317) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2674113..2675426 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2675352..2675371) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2675371) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2675384 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2675386..2675393) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2675454..2676926) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2675454..2676926) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2675464) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2676807..2676811 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2676814 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2676924 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2676942..2677493) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2676942..2677493) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2677515..2677534) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2677528) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2677547..2677554) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2677590..2677988) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2677590..2677988) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2677989..2678059) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2678060..2678308) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2678060..2678308) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2678331..2678350) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678342) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2678366..2678369) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2678381..2678602) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2678381..2678602) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2678408) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2678596 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2678620..2678639) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2678626) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2678652..2678661) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2678662..2679771) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2678662..2679771) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2679423..2679430 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2679445..2679464 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2679454..2679848 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2679454 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2679819..2679838) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2679835) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2679837..2680277) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2679840..2679842 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2679850 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2679852..2679857) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2679858..2679877 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2679886..2680275 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2679886..2680275 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2680316..2680552) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2680316..2680552) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2680322) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2680572..2680591) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680586) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2680588..2680728) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2680605..2680614) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2680729..2681259) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2680729..2681259) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2681279..2681298) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2681290) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2681292..2681378) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2681310..2681318) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2681373..2681392) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2681380) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2681406..2681415) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2681457..2682188) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2681457..2682188) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2681487) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2682203..2682222) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682214) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2682237..2682244) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2682251..2682706) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2682251..2682706) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2682659..2682665 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2682680..2682698 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2682688..2685055 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2682688 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2682738..2685968) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2682738..2685968) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2685965..2690452) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2685965..2690452) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2689727..2689733 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2689748..2689766 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2689754..2690716 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2689754 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2690513..2691868) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2690513..2691868) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2690534) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2691883..2692122) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2691883..2692122) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2692192..2692485) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2692192..2692485) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2692202) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2692479 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2692486..2692564) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2692527..2692534 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2692544..2692563) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692545 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2692549..2692566 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692564) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692578..2692585) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2692623..2692628 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692643..2692662 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2692655..2692761 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2692655 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2692830..2692836 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2692850..2692869 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2692853 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2692958..2692961 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2692970 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2692973..2692992) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2692977..2692996 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2692995) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2693006..2694274 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2693006..2694274 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2693007..2693014) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2694334..2694353 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2694339 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2694376..2695512 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2694376..2695512 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2695512 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2695561..2695569 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2695579 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2695581..2695599 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2695624..2696301 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2695624..2696301 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2696285 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2696345..2696554) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2696345..2696554) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2696357) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2696570..2703706) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2696570..2703706) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2703726..2704664) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2703726..2704664) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2704692..2706311) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2704692..2706311) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2706340..2707536) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2706340..2707536) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2707384..2707391 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707406..2707425 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707413 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2707562..2708347) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2707562..2708347) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2708348..2708457) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2708452..2708471) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2708457) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2708459..2708540) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2708485..2708492) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2708541..2709410) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2708541..2709410) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2709411..2709491) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2709475..2709494) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709491) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709508..2709515) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709624..2710220) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2709624..2710220) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2710221..2710305) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2710256..2710263 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2710273 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2710278..2710297 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2710299..2710313) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710305) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710321..2710325) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2710321..2710923 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2710321..2710923 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2710909 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2710993..2712321) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2710993..2712321) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2711009) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2712375..2712394) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712378) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712409..2712416) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712468..2713970) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2712468..2713970) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2712483) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2713535..2713549 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2713551 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2713971..2714045) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2713993..2714000 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714011..2714030 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2714013..2714127 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2714013 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2714040..2714059) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2714050) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2714128..2714604 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2714128..2714604 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2714553 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2714635..2715291) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2714635..2715291) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2714663) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2714939..2714948 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2714962..2714981 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2714979 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2714981..2715427 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2715305) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2715307..2715318) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2715333..2715339) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2715384 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2715395..2715715) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2715395..2715715) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2715409) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2715429..2715639 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2715581..2715681 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2715641..2715750 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2715641 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2715707 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2715734..2715753) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715739) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2715752..2716303 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2715768..2715775) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2715769..2715912) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2715769..2715912) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2715936..2715955) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2715957) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2715971..2715974) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2716085..2717305) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2716085..2717305) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2716113) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2717306..2717433) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2717433) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2717435..2717499) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2717435..2717453) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2717469..2717474) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2717490..2717509) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717498) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717524..2717531) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2717573..2717580 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2717592..2717611 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2717592 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2717637..2718635 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2717637..2718635 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2717660..2717678) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2717675) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717695..2717700) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2718611 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2718674..2718814) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2718674..2718814) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2718686) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2718815..2718944) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2718925..2718944) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2718944) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2718946..2719193) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2718958..2718964) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2719001..2719008 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719022..2719041 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719030 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2719093..2720073 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2719093..2720073 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2719194) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2719198..2719209) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2719223..2719229) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2720041 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2720146) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2720147..2720770) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2720147..2720770) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2720794..2721312) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2720794..2721312) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2721359..2721378) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2721371) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2721373..2721481) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2721468..2721485) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721479) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721500..2721507) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2721635) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2721650..2722012) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2721650..2722012) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2722043..2722062) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722053) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722076..2722083) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2722091..2722945) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2722091..2722945) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2722661..2722680) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722669) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2722693..2722702) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2722967..2722986) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2722981) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723001..2723004) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723068..2724282) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2723068..2724282) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2723617..2723623 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2723638..2723656 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2723645 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2723649..2724418 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2724319..2724338) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2724324) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2724353..2724360) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2724375 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2724419..2724655) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2724419..2724655) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2724420..2724836 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2724437) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2724620..2724621) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2724625..2724629) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2724627) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2724670..2724689) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2724671) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2724703..2724710) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2724813..2724818 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2724832..2724851 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2724838 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2724918..2725985 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2724918..2725985 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2725969 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2726011..2726337) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2726011..2726337) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2726034) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2726369..2726388) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2726386) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2726401..2726408) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2726421..2726425 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2726437..2726772 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2726437..2726772 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2726438..2726457 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2726443 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2726562) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2726750 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2726814..2728787) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2726814..2728787) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2726826) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2728802..2728820) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728825) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2728832..2728840) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2728895..2729824) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2728895..2729824) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2728908) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2729821..2730879) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2729821..2730879) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2730879..2732180) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2730879..2732180) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2732065..2732074 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2732089..2732108 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2732096 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2732181..2732262) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2732247..2732266) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732262) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2732264..2732380) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2732281..2732288) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2732381..2733400) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2732381..2733400) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2733208..2733213 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733229..2733247 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733233 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2733423..2733441) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733430) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2733439..2733444 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2733457..2733462) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2733460..2733524 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2733460..2733478 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733460 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2733497..2733506 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2733519..2733538 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2733526 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2733553..2734053 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2733553..2734053 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2734080..2734850) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2734080..2734850) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2734108) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2734879..2735313) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2734879..2735313) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2735337..2735612) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2735337..2735612) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2735632..2735651) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2735657) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2735659..2736351) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2735665..2735672) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2735675..2735681 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2735696..2735707 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2735704 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2735727..2736359 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2735727..2736359 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2736320 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2736375..2737271) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2736375..2737271) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2736396) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2737272..2737406) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2737393..2737412) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2737406) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2737428..2737432) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2737446..2737452 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2737466..2737477 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737478 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2737506..2738486 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2737506..2738486 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2737584) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2737598..2737617) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2737634..2737637) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2738478 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2738514..2739278) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2738514..2739278) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2738530) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2739292..2739310) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739300) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739326..2739331) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739351..2739656) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2739351..2739656) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2739359) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2739670..2739689) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739693) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739703..2739711) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739721..2741109) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2739721..2741109) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2741129..2741950) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2741129..2741950) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2741968..2742816) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2741968..2742816) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2742335..2742340 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2742356..2742374 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2742370 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2742827..2742846) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2742842) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2742854..2743201) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2742854..2743201) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2743214..2743233) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743233) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2743247..2743253) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743298..2744638) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2743298..2744638) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2743326) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2744382) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2744695..2744701 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2744715..2744734 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2744717..2744735) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744723 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2744724..2744812 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2744734) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2744751..2744756) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2744813..2746408 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2744813..2746408 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2746553..2747902 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2746553..2747902 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2747908..2749200 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2747908..2749200 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2749213..2750697 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2749213..2750697 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2750697..2751041 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2750697..2751041 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2750763..2750766 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2750784..2750803 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2750796 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2751016 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2751057..2751444) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2751404..2751413 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2751426..2751445 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2751429 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2751465..2751596) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2751465..2751596 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2751465..2751596 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2751465..2751596) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2751597..2751665 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2751632 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2751802..2752323) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2751802..2752323) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2752314..2754551) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2752314..2754551) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2754552..2755385) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2754552..2755385) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2755382..2755999) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2755382..2755999) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2755491) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2755996..2756988) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2755996..2756988) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2756989..2757075) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2757053..2757072) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2757075) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2757086..2757091) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2757217..2758467) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2757217..2758467) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2758484..2759722) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2758484..2759722) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2759945..2760082 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2759945..2760082 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2760104..2760107 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2760122..2760141 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760123 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2760164..2761030 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2760164..2761030 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2761033 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2761064..2762167) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2761064..2762167) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2761079) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2762168..2763101) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2762205..2762212 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762226..2762245 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762236 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2762287..2762293 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2762304 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2762308..2762327 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2762349..2763077 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2762349..2763077 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2763102..2763956) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2763102..2763956) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2763289..2763308) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2763301) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2763459..2763559) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2763499) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2763970..2764872) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2763970..2764872) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2764876..2765754) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2764876..2765754) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2765812..2767080) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2765812..2767080) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2766971..2767071 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2767031 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2767151) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2767161..2768147) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2767161..2768147) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2768094 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2768097..2768101 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2768190..2768209) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768203) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2768224..2768231) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2768361) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2768363..2768737) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2768363..2768737) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2768801) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2768808..2768819) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2768833..2768839) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2768840..2769958) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2768840..2769958) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2769983..2770002) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2769989) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2769991..2770601) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2770016..2770022) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2770055..2770064 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2770078..2770097 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2770082 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2770095..2770110) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770099) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2770117..2770121) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2770117..2770263 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2770117..2770263 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2770263..2770538 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2770263..2770538 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2770407) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2770423..2770437) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2770446..2770450) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2770518 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2770602..2770985) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2770602..2770985) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2770986..2771095) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2771096..2771374) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2771096..2771374) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2771372..2771391) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2771396) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771406..2771413) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2771537..2771643) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2771580) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2771644..2773041) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2771644..2773041) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2772839 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2773062..2773505) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2773062..2773505) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2773495..2774715) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2773495..2774715) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2774715..2776028) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2774715..2776028) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2776046..2776831) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2776046..2776831) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2776875..2776894) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2776876) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2776908..2776915) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2776932..2776951) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2776941) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2776943..2777024) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2776967..2776971) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2776988..2777235) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2776988..2777235) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2777025..2777162) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2777025..2777162) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2777163..2777247) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2777231..2777250) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2777247) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2777249..2777355) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2777266..2777269) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2777356..2777733) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2777356..2777733) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2777750..2777761) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2777756) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2777775..2777781) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2777818..2778642) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2777818..2778642) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2777826) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2777975) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2778002..2778007 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2778023..2778041 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2778025 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2778656..2779324) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2778656..2779324) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2779317..2780342) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2779317..2780342) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2780343..2780447) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2780448..2780554) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2780448..2780554) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2780517 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2780581..2780600) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780593) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2780595..2780668) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2780616..2780623) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2780669..2781013) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2780669..2781013) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2781014..2781119) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2781120..2781440) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2781120..2781440) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2781442..2781882) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2781442..2781882) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2781882..2782118) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2781882..2782118) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2781894) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2782133) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2782138..2782149) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2782164..2782170) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2782174..2782557) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2782174..2782557) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2782584..2782603) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2782595) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2782616..2782623) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2782624..2782980) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2782624..2782980) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2783003..2783022) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2783013) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2783036..2783041) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2783091..2784875) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2783091..2784875) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2783101) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2784890..2786065) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2784890..2786065) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2786076..2788445) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2786076..2788445) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2787864..2787869 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2787884..2787902 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2787887 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2788513..2788532) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2788516) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2788524..2788790) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2788546..2788553) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2788571..2788577 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2788592..2788603 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2788614 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2788620..2788766 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2788620..2788766 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2788767..2789793 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2788791..2789699) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2788791..2789699) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2789700..2790222) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2789794..2790039 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2789794..2790039 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2790052..2790384 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2790052..2790384 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2790205..2790224) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2790222) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2790238..2790247) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2790373 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2790445..2790452 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2790466..2790485 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2790477 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2790543..2791010 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2790543..2791010 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2791007..2792632 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2791007..2792632 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2792617 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2792668..2793051) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2792668..2793051) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2793070..2793459) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2793070..2793459) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2793481..2793810) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2793481..2793810) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2793845..2793864) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2793852..2793859 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2793859) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2793874..2793893 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2793878..2793885) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2793884 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2793944..2794831 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2793944..2794831 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2794851..2795138) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2794851..2795138) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2794863) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2795163..2795990) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2795163..2795990) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2795179) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2795991..2796128) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2796113..2796132) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2796128) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2796148..2796151) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2796208..2796645) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2796208..2796645) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2796669..2796687) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2796675) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2796703..2796708) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2796755..2798263) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2796755..2798263) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2796776) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2798254..2798550) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2798254..2798550) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2798573..2798592) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2798589) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2798607..2798610) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2798627..2798632 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2798644..2798663 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2798644 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2798684..2799526 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2798684..2799526 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2799056..2799062 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2799077..2799088 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2799085 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2799553..2799560 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2799569 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2799572..2799591 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2799616..2800077 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2799616..2800077 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2800053 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2800121..2801497) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2800121..2801497) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2800129) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2801498..2801669) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2801650..2801669) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801669) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801680..2801687) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2801730..2801749) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2801740..2801759 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2801742 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2801748) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2801750..2802813) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2801764..2801771) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2801775..2802452 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2801775..2802452 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2802449..2803804 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2802449..2803804 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2802903..2803831) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2803772 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2803832..2803996) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2803832..2803996) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2804020..2804027 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2804041..2804060 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2804045..2804064) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2804051..2804163 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2804051 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2804058) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2804060..2804338) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2804078..2804085) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2804164..2805039 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2804164..2805039 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2804328..2804347) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804338) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2804340..2804881) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2804361..2804368) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2804873..2804891) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2804881) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2804883..2805012) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2804904..2804911) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2805014 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2805057) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2805075..2806463) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2805075..2806463) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2806487) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2806492..2806510) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2806521..2806529) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2806530..2806715) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2806530..2806715) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2806719 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2806759..2806778) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2806768..2806774 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2806773) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2806788..2806799 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806791 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2806794..2806797) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2806833..2808281 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2806833..2808281 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2807829..2810472) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2808250..2809347 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2808250..2809347 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2809344..2810465 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2809344..2810465 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2810473..2811108) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2810473..2811108) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2811086..2812168) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2811086..2812168) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2812165..2812890) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2812165..2812890) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2812924..2813796) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2812924..2813796) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2813815..2813834) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813835) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813849..2813852) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2813897..2814574) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2813897..2814574) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2813913) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2814601..2814981) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2814601..2814981) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2815004..2815023) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815024) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2815038..2815041) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2815143..2816411) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2815143..2816411) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2815156) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2816445..2816464) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816456) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2816479..2816486) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2816582) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2816588..2817169) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2816588..2817169) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2817192..2818520) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2817192..2818520) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2818520..2819581) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2818520..2819581) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2819544..2820488) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2819544..2820488) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2820489..2820758) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2820597..2820727) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2820597..2820727) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2820735..2820754) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2820758) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2820760..2821687) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2820770..2820777) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2820820..2820827 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2820842..2820861 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2820846 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2820886..2821677 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2820886..2821677 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2821548 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2821658 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2821715..2822593) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2821715..2822593) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2821732) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2822617..2822635) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822636) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822649..2822655) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2822665..2824407) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2822665..2824407) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2824404..2825117) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2824404..2825117) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2825148..2825167) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2825166) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2825270..2825509) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2825270..2825509) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2825277) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2825505..2825523) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2825513..2826043) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2825513..2826043) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2825514) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2825538..2825544) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2826046..2826065) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826053) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2826058..2826396 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2826058..2826396 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2826080..2826087) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2826096..2826115) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826108) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2826130..2826136) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2826142..2826242 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2826202 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2826370..2826470 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2826430..2826516 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2826430 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2826517..2827674 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2826517..2827674 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2827660 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2827735..2828145 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2827735..2828145 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2828144 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2828179..2829408) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2828179..2829408) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2828196) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2829401..2830090) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2829401..2830090) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2830074..2831267) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2830074..2831267) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2831311..2831330) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2831324) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2831345..2831352) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2831438..2832247) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2831438..2832247) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2831455) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2831594..2831603 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2831616..2831635 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2831620 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2832263..2833273) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2832263..2833273) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2833273..2834427) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2833273..2834427) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2834360..2834379) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834377) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2834391..2834398) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2834439..2834446 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2834461..2834480 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2834470 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2834525..2835472 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2834525..2835472 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2835448 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2835492 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2835646 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2835707..2837116) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2835707..2837116) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2835722) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2836534..2836538 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2836556..2836572 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2836563 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2836570..2837537 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2837218) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2837220..2837399) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2837220..2837399) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2837429..2837446) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837440) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837461..2837468) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2837494 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2837516..2837656) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2837516..2837656) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2837526) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2837684) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2837686..2838274) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2837689..2837700) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2837714..2837720) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2837746..2837753 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2837767 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2837769..2837788 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2837823..2838305 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2837823..2838305 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2838319..2838326 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2838340..2838359 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2838352 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2838405..2840258 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2838405..2840258 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2840244 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2840286..2841212) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2840286..2841212) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2840298) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2841224..2841243) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841245) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841259..2841262) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2841281..2841300 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2841290 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2841323..2842105 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2841323..2842105 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2842077..2842769 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2842077..2842769 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2842761 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2842800..2843630) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2842800..2843630) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2842806) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2843493..2843497 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843513..2843517 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843522 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2843632 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2843660..2843679) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2843678) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2843694..2843701) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2843786..2843792 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2843806 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2843807..2843825 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2843853..2844338 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2843853..2844338 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2844337 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2844382..2846394) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2844382..2846394) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2844390) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2846060..2846064) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2846062) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2846395..2846546) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2846523..2846541) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2846546) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2846649..2848364) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2846649..2848364) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2846656) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2848390..2850207) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2848390..2850207) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2850249..2850268) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2850258..2850265 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2850268) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2850271 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2850278..2850297 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2850281..2850288) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2850378..2852702) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2850378..2852702) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2850396) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2852722..2852729 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2852744..2852763 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2852745..2852760) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2852748 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2852750) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2852795..2852814) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852804) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852830..2852836) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2852840..2852859) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852860) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852873..2852881) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2852887) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2852900..2853508) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2852900..2853508) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2853547..2853566) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2853564) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2853582..2853586) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2853695..2854111) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2853695..2854111) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2853705) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2854116..2854784) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2854116..2854784) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2854836..2854855) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2854851) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2854862) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2854869..2854874) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2854904..2857012) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2854904..2857012) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2857004..2857105) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2857099..2857118) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2857105) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2857134..2857141) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2857172..2859580) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2857172..2859580) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2857194) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2857260) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2859581..2859663) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2859664..2859873) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2859664..2859873) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2859897..2859916) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2859918) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2859929..2859935) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2859947..2860252) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2859947..2860252) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2860216..2860235 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2860227 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2860266..2860285) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2860292) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2860299..2860305) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2860344..2860350 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2860365..2860383 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2860373 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2860380..2861456 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2860380..2861456 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2861443 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2861493..2862128) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2861493..2862128) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2861506) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2862129..2862226) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2862206..2862225) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2862226) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2862239..2862245) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2862288..2864183) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2862288..2864183) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2864234..2864245) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864234) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2864260..2864266) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2864333) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2864346..2864747) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2864346..2864747) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2864744..2865103) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2864744..2865103) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2865100..2865672) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2865100..2865672) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2865710..2865729) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865715) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865743..2865750) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2865783..2866577) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2865783..2866577) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2866598..2866616) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866610) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2866631..2866637) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2866643..2866662) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866654) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2866656..2866721) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2866676..2866683) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2866763..2867122) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2866763..2867122) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2866766) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2867106..2867114) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867116) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2867129..2867134) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2867174..2867193) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867182) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2867184..2867248) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2867206..2867210) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2867248) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2867249..2867268) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2867283..2867290) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2867299..2867769) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2867299..2867769) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2867596..2867696 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2867656 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2867766 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2867814..2867833) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2867820) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2867822..2867913) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2867849..2867852) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2867914..2870253) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2867914..2870253) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2869014..2869017 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2869033..2869036 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2869042 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2870272..2871012) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2870272..2871012) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2870668..2870686) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2870680) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2870701..2870707) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2871040..2871058) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2871054) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2871142) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2871144..2871374) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2871144..2871374) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2871404..2871423) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2871425) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2871438..2871441) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2871463..2871469 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2871483..2871494 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871484 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2871523..2872293 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2871523..2872293 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2871545..2871553 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2871564..2871582 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871594 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2872333..2872566) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2872333..2872566) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2872657..2872664 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2872672 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2872676..2872695 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2872718..2873125 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2872718..2873125 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2873155..2873574 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2873155..2873574 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2873612..2873619 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2873633..2873652 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2873640 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2873666..2873992 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2873666..2873992 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2873993..2874077 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2874048..2874055 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2874068..2874086 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2874079 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2874117..2875817 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2874117..2875817 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2874833..2875826) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2875795 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2875857..2876537) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2875857..2876537) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2875871) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2876231..2876237 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2876252..2876270 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2876257..2879008 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2876257 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2876554..2877474) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2876554..2877474) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2877486..2878139) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2877486..2878139) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2878156..2879301) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2878156..2879301) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2879302..2879369) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2879369) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2879370..2879389) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2879400..2879404 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2879404..2879407) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879420..2879438 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879425 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2879520..2879524 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2879540..2879559 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2879543 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2879585..2880118 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2879585..2880118 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2879785..>2880184) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2880107 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2880184,2880191) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2880185..2880190 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2880191..2880266 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2880191..2880257) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2880262..2880951) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2880262..2880951) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2880302) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2880894..2880902 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880916..2880935 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2880930 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2880969..2881880) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2880969..2881880) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2881900..2882553) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2881900..2882553) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2882576..2883718) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2882576..2883718) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2883762..2883781) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2883777) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2883796..2883799) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2883915..2883922 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2883935..2883954 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2883946 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2883982..2884539 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2883982..2884539 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2884540..2885304 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2884557..2885192) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2884557..2885192) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2884570) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2885233..2885251) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885239) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885267..2885273) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2885278..2885285 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885297..2885316 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885306 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2885342..2885956 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2885342..2885956 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2885942 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2886010..2886013 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2886028..2886047 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2886036 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2886088..2886786 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2886088..2886786 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2886759 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2886822..2888639) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2886822..2888639) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2886841) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2887012) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2888681..2888700) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2888685..2888704 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2888690 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2888694) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2888759..2889226 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2888759..2889226 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2889223 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2889271..2890563) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2889271..2890563) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2889281) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2890593..2892128) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2890593..2892128) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2892121..2892882) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2892121..2892882) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2892913..2894097) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2892913..2894097) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2894098..2894338) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2894338) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2894340..2894413) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2894352..2894371) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2894387..2894391) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2894414..2895421) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2894414..2895421) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2895340..2895343 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2895360..2895362 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2895362 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2895468..2896490) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2895468..2896490) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2895484) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2895512..2895513) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2896491..2896602) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2896528 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2896583..2896602) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896602) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2896604..2896714) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2896616..2896623) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2896697..2896716) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2896712) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2896729..2896738) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2896788..2898182) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2896788..2898182) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2896802) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2898281..2898300) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2898295) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2898315..2898322) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2898322..2898329 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2898343..2898362 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2898349 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2898386..2899474 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2898386..2899474 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2899454 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2899523..2900533) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2899523..2900533) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2899530) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2900534..2900611) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2900601..2900620) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2900611) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2900634..2900641) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2900690..2901568) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2900690..2901568) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2901226..2901232 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2901247..2901258 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2901258 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2901602..2901609 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2901615..2901634) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2901620) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2901623..2901642 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2901625 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2901648..2901652) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2901668..2902585 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2901668..2902585 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2902574 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2902626..2903969) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2902626..2903969) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2904038..2904273) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2904038..2904273) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2904172) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2904274..2904370) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2904371..2905405) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2904371..2905405) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2905427..2905445) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2905433) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2905458..2905465) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2905513..2906235) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2905513..2906235) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2905529) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2906235..2907674) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2906235..2907674) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2907222..2907225 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2907242 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2907243..2907247 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2907396 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2907550 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2907551..2907552 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2907701..2908417) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2907701..2908417) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2908321..2908328 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2908342..2908344 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2908342 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2908415 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2908418..2908484) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2908481..2908500) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2908484) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2908515..2908522) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2908592..2909194) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2908592..2909194) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2909211..2910326) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2909211..2910326) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2910330..2911067) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2910330..2911067) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2910356..2910375) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2910370) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2910387..2910394) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2911068..2911973) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2911068..2911973) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2911993..2912011) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2912004) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912027..2912030) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2912182..2912189 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912200..2912219 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912207 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2912257..2913066 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2912257..2913066 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2913102..2914313 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2913102..2914313 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2914300 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2914367..2915656) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2914367..2915656) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2915736..2917799) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2915736..2917799) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2917818..2918669) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2917818..2918669) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2918673..2919929) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2918673..2919929) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2919969..2921234) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2919969..2921234) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2921266..2921285) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2921288) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2921300..2921307) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2921375..2922367) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2921375..2922367) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2921409) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2922497..2922546) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2922520) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2922547..2923206) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2922547..2923206) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2923207..2923312) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2923304..2923323) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923313) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923338..2923341) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2923365..2923372 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923387..2923406 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923387 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2923390..2923495 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2923396..2923413) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923400) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923421..2923427) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2923496..2925187 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2923496..2925187 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2925172 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2925214..2926524) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2925214..2926524) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2925217..2926287 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2925226) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2926344..2926363 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2926344..2926602 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2926344 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2926538..2926557) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2926553) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2926572..2926575) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2926603..2926821 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2926603..2926821 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2926800 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2926828,2926835) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2926829..2926834 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2926866..2926869 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2926875 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2926886..2926904 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2926920..2928389 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2926920..2928389 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2928366 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2928392..2928583 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2928392..2928583 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2928562 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2928610..2929095) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2928610..2929095) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2929118..2929429) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2929118..2929429) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2929481..2929573) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2929481..2929573) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2929613..2929632) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2929630) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2929646..2929653) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2929704..2930387) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2929704..2930387) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2929722) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2930403..2931758) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2930403..2931758) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2931770..2931785) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2931786) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2931797..2931806) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2932060..2932067 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2932081..2932100 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2932084 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2932106..2932296 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2932297..2933718 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2932297..2933718 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2933712 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2933792..2935342 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2933792..2935342 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2935386..2935392 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2935406..2935417 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2935406 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2935450..2937012 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2935450..2937012 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2936990 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2937002..2937691 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2937002..2937691 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2937041..2937048 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2937062..2937081 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2937071 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2937672 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2937770) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2937773..2938108 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2937773..2938108 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2938108..2938428 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2938108..2938428 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2938429..2938619 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2938464..2938976) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2938464..2938976) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2938596 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2939012..2939023) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2939018) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2939038..2939044) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2939091..2939227) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2939134) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2939228..2940571) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2939228..2940571) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2940600..2940619) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2940608) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2940632..2940641) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2940633..2940638 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2940654..2940672 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2940657 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2940866..2940875 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2940884 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2940889..2940908 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2940927..2941889 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2940927..2941889 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2941890..2942143 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2942170) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2942174..2942249) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2942174..2942249) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2942276..2942295) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2942297) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2942311..2942314) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2942380..2942386 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2942396..2942471 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2942396 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2942401..2942420 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2942448..2942455 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2942469..2942488 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2942473 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2942519..2943112 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2942519..2943112 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2943101 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2943146..2943544 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2943158..2943838) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2943158..2943838) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2943182) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2943835..2945520) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2943835..2945520) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2945513..2947786) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2945513..2947786) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2947764..2948648) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2947764..2948648) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2948654..2949490) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2948654..2949490) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2949491..2950798) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2949491..2950798) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2949856..2949865 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949878..2949897 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2949882 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2950838..2952091) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2950838..2952091) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2952092..2952186) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2952187..2953956) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2952187..2953956) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2953877..2953882 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2953898..2953916 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2953908 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2953994..2954013) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954007) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2954026..2954033) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2954069..2955019) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2954069..2955019) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2955034..2955052) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2955047) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2955064..2955072) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2955153) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2955225..2955800) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2955225..2955800) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2955237) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2955843..2955862) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2955849..2955856 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2955859) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2955866 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2955869..2955888 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2955877..2955884) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2955917..2956237 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2955917..2956237 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2956218 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2956264) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2956264..2957856) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2956264..2957856) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2957875..2958468) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2957875..2958468) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2958510..2958529) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2958523) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2958544..2958548) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2958594..2958599 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958615..2958633 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958616 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2958789..2958796 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2958810..2958829 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2958814 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2958851..2959828 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2958851..2959828 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2959800 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2959866..2961806) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2959866..2961806) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2959890) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2961781..2962560) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2961781..2962560) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2962561..2962642) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2962643..2963713) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2962643..2963713) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2963707..2964420) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2963707..2964420) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2964466..2964485) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2964478) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2964480..2964741) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2964498..2964501) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2964501..2964508 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2964519..2964538 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2964524 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2964567..2964776 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2964567..2964776 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2964754 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2964786) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2964812..2965576) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2964812..2965576) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2964834) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2965577..2965834) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2965577..2965834) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2965858..2966808) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2965858..2966808) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2966831..2967784) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2966831..2967784) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2967786..2968673) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2967786..2968673) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2968698..2969174) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2968698..2969174) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2969194..2969213) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969208) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969229..2969233) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2969252..2969271) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969265) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969286..2969289) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2969341..2969491) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2969384) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2969492..2970442) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2969492..2970442) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2970443..2970530) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2970519..2970538) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970530) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2970532..2970623) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2970553..2970556) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2970571..2970577 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970591..2970609 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970605 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2970606..2973992 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2970648..2972069) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2970648..2972069) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2970668) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2970792) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2971696..2971700 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2971706 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2971985..2971989 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2971992 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2972070..2972267) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2972190 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2972255..2972274) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2972267) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2972286..2972293) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2972450..2973904) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2972450..2973904) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2972470) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2973905..2974029) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2973950 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2974030..2975799) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2974030..2975799) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2975800..2975874) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2975863..2975882) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2975874) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2975964..2976323) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2975964..2976323) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2975984) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2976338..2978248) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2976338..2978248) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2978250..2978792) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /modified_by="User" /translation="MVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGKNKE SIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKKTDI YTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDEEKA KNKVEKLINSITFLIDKKEK*" /label="PG10_pseudo_BSU_34850" gene complement(2978250..2978792) /gene="yvcA" /locus_tag="PG10_pseudo_BSU_34850" /old_locus_tag="BSU_34850" /modified_by="User" /label="PG10_pseudo_BSU_34850" N_region 2978851..2979900 /comment="Inserted sequence is a combination of three independent chromosomal regions. First the arabinose inducible mtlA promoter, second a copy of the original comK gene as well as third a copy of the original comS gene." /modified_by="User" /label="IIG_Bs27_024" promotor_-35 2978911..2978918 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2978932..2978951 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2978937 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" CDS 2979011..2979589 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 2979011..2979589 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" CDS 2979638..2979778 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 2979638..2979778 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" S_feature complement(<2979901..2979942) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" CDS complement(2979968..2980597) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2979968..2980597) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2979987) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2980594..2981352) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2980594..2981352) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2981349..2982086) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2981349..2982086) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2982083..2982721) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2982083..2982721) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2982579..2982679 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2982639 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2982722..2983306) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2982722..2983306) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2983303..2984586) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2983303..2984586) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2984583..2985224) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2984583..2985224) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2985217..2986392) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2985217..2986392) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2986393..2986470) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2986436..2986442 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986454..2986473 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2986454..2986473) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986467 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2986470) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2986486..2986493) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2986602..2986621 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2986609 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2986643..2987395 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2986643..2987395 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2987396..2987634 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2987417..2987428) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2987423) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2987443..2987449) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2987635..2988300 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2987635..2988300 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2988271 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2988320..2988838) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2988320..2988838) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2988354) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2988842..2989492) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2988842..2989492) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(2989489..2990427) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(2989489..2990427) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(2990451..2991260) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(2990451..2991260) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(2991274..2992206) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(2991274..2992206) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(2992248..2992267) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992254) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2992283..2992288) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2992323..2992330 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2992342 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2992345..2992362 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2992388..2993578 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 2992388..2993578 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 2993376..2993382 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2993397 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2993398..2993416 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2993575..2994303 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 2993575..2994303 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 2994321..2995052 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 2994321..2995052 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(2995072..2998941) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(2995072..2998941) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(2995194) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2998961..2998972) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998968) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998987..2998993) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2999031..2999037 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999051..2999070 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2999056 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 2999106..2999579 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 2999106..2999579 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 2999580..2999687 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(2999620..3000837) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(2999620..3000837) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(2999633) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2999659..2999664 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2999679..2999690 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2999689..2999974 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 2999689 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 2999931 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3000853..3001599) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3000853..3001599) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3001600..3001786) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3001772..3001791) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3001786) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3001805..3001812) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3001920..3001927 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3001942..3001961 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3001954 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3001955..3002024 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3002025..3002534 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3002025..3002534 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3002430..3003768) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3002471) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3002555..3003766 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3002555..3003766 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3003764 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3003794..3004153) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3003794..3004153) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3003809..3004525 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3003813) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3004155..3004352) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3004155..3004352) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3004357..3005454) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3004357..3005454) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3005479..3005805) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3005479..3005805) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3005858..3005873) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005873) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3005875..3006365) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3005885..3005894) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3005953..3005956 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3005971..3005990 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3005981 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3006023..3006253 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3006023..3006253 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3006356..3006375) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3006366) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3006391..3006395) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3006452..3006934) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3006452..3006934) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3006460 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3006475) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3006607) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3006615..3006618) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3006695..3006699) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006695) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3006715..3006718) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3006935..3007068) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3007096..3009969) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3007096..3009969) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3007113) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3009977..3011962) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3009977..3011962) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3011996..3012015) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012008) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3012010..3012095) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3012027..3012034) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3012140) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3012148..3012378) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3012148..3012378) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3012405..3012424) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3012415) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3012417..3012481) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3012438..3012445) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3012458..3012476) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012479) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3012491..3012497) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3012547) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3012573..3012673) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3012613) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3012695..3012702 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012716..3012735 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3012733 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3012825..3015320 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3012825..3015320 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3015335..3015339 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3015353 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3015396..3015965 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3015396..3015965 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3015996..3017330 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3015996..3017330 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3017311 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3017378..3018571) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3017378..3018571) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3017387) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3017452) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3018572..3018649) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3018575) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3018650..3018988) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3018650..3018988) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3018963..3019079) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3018963..3019079) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3019080..3019169) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3019151..3019169) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3019169) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3019171..3019251) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3019183..3019188) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3019237..3019255) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3019251) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3019269..3019276) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3019388..3020830) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3019388..3020830) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3019477) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3020876..3020887) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3020887) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3020902..3020908) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3020970..3021860) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3020970..3021860) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3020987) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3021853..3022539) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3021853..3022539) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3022540..3022672) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3022662..3022681) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022672) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3022696..3022699) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3022773..3023111) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3022773..3023111) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3022774) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3023138..3023157) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3023151) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3023160..3024044) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3023160..3024044) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3023171..3023178) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3024032..3024051) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3024053) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3024066..3024073) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3025201..3025272), complement(3024171..3025199)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3024171..3025272) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3024187) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3025273..3025341) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3025342..3027867) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3025342..3027867) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3027868..3027948) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3027938..3027957) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3027948) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3028035..3028604) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3028035..3028604) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3028043) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3028571..3028577 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3028590..3028609 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3028597 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3028631..3028649) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3028639) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3028641..>3028742) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3028661..3028669) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3028742..3028743 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3028746..3029228) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3028746..3029228) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3029244..3029510) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3029244..3029510) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3029511..3029590) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3029591..3030010) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3029591..3030010) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3030049..3030067) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3030060) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3030081..3030088) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3030084..3030806) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3030084..3030806) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3030770..3031066) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3030770..3031066) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3031092..3031111) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031105) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3031122..3031129) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3031126..3032517) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3031126..3032517) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3032531..3032550) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3032546) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3032564..3032571) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3032623..3033468) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3032623..3033468) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3032634) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3032885..3032892 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3032906..3032925 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3032916..3034648 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3032916 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3033495..3033514) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033514) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3033529..3033532) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3033566..3034255) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3033566..3034255) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3033580) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3034256..3034337) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3034338..3035495) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3034338..3035495) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3035496..3035623) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3035543..3035546 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3035561..3035580 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3035572..3035658 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3035572 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3035617..3035636) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3035623) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3035640..3035648 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3035647..3035654) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3035660 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3035662..3035670 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3035712..3036365 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3035712..3036365 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3036068..3036660) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3036365..3037540 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3036365..3037540 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3036656..3036674) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036665) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036688..3036694) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3037512 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3037613..3038689) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3037613..3038689) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3037629) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3037675..3037684 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3037698..3037717 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3037706..3038939 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3037706 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3038690..3038772) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3038760..3038779) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3038772) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3038791..3038797) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3038834..3040027) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3038834..3040027) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3038864) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3040056..3040814) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3040056..3040814) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3040838..3041518) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3040838..3041518) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3041547..3043013) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3041547..3043013) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3043014..3043097) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3043098..3044483) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3043098..3044483) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3044545..3045714) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3044545..3045714) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3045711..3047162) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3045711..3047162) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3047218..3047367) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3047218..3047367) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3047312..3047851) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3047312..3047851) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3047907..3047924) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3047911) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3048078..3049568) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3048078..3049568) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3048100) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3049607..3051724) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3049607..3051724) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3051748..3052056) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3051748..3052056) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3051962 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3052052..3052056 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052065..3052079 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3052066..3052084) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3052072 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3052098..3052105) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3052101) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3052122..3052130 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3052144..3052157 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3052162 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3052240..3053160 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3052240..3053160 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3053150 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3053200..3054342) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3053200..3054342) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3053224) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3054381..3054400) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3054395) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3054415..3054418) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3054471..3054475 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3054491..3054510 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3054492..3054587 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3054493 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3054588..3055466 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3054588..3055466 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3055467..3056558 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3055536..3055891) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3055800..3056018 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3055800..3056018 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3055892..3055975) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3055892..3055975) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3055976..3056167) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3056168..3058870) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3056168..3058870) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3058871..3058993) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3058892..3058898 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3058913..3058931 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3058918..3061750 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3058918 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3058994..3060334) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3058994..3060334) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3060375..3060581) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3060375..3060581) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3060582..3061455) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3061449..3061468) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061455) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3061457..3061696) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3061481..3061487) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3061678..3061696) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3061696) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3061710..3061717) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3061719..3061726 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3061738..3061757 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3061752..3061882 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3061752 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3061824..3061924 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3061884 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3061888..3062484 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3061888..3062484 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3062082 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3062523..3064106) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3062523..3064106) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3062566 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3064126..3064953) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3064126..3064953) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3064954..3065018) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3065014..3065033) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065018) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3065020..3065117) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3065049..3065052) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3065118..3067358) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3065118..3067358) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3067358..3069379) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3067358..3069379) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3068121..3068130 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3068143..3068158 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3068154 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3069380..3069539) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3069540..3069929) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3069540..3069929) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3069930..3070064) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3070048..3070067) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070064) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3070078..3070085) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3070219..3070225 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3070236..3070328 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3070236 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3070237..3070256 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3070329..3071099 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3070329..3071099 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3070456..3070804) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3070808..3070819) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3070812) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3070834..3070840) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3071124 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3071132..3072277 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3071132..3072277 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3072265 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3072319..3072326 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072341..3072360 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3072351 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3072397..3073725 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3072397..3073725 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3073720 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3073781) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3073805..3073806 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3073829 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3073882..3075123) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3073882..3075123) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3073901) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3075145..3075163) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075167) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3075176..3075183) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3075264..3075431) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3075264..3075431) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3075291) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3075446..3076588) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3075446..3076588) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3076607..3077056) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3076607..3077056) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3076750..3076756 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3076764 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3076770..3076788 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3076777..3078986 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3077071..3078252) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3077071..3078252) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3078966..3078973 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3078988 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3078989..3079008 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3079009) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3079014..3079028) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3079036..3079040) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3079036..3080016 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3079036..3080016 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3079865..3079872 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3079886..3079905 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3079901 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3080018..3080899 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3080018..3080899 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3080896..3081291 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3080896..3081291 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3081307..3082788 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3081307..3082788 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3082790..3083758 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3082790..3083758 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3083770..3084687 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3083770..3084687 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3084696..3084702 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3084717..3084735 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3084719 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3084769..3085305 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3084769..3085305 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3085288 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3085333..3085443 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3085412..3085418 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3085433..3085444 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3085445 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3085461..3085757 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3085461..3085757 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3085758..3086410 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3085797..3086324) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3085797..3086324) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3085807) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3086344..3086363) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3086357) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3086368 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3086377..3086384) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3086423) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3086424..3087191) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3086424..3087191) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3087253..3088965) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3087253..3088965) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3087864..3087873 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087887..3087906 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3087887 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3089019..3089038) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089024) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3089044..3089051 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3089053..3089057) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3089065..3089084 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3089075 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3089123..3090031 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3089123..3090031 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3090099..3090107 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3090109..3090241 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3090109 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3090121..3090140 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3090242..3091570 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3090242..3091570 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3091561 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3091627..3092304) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3091627..3092304) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3091637) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3092364..3093506) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3092364..3093506) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3093543..3093562) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3093551) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3093553..3093633) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3093576..3093584) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3093634..3094722) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3093634..3094722) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3094723..3094836) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3094778..3094787 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3094800..3094819 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3094813 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3094836) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3094840..3094854) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3094863..3094867) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3094863..3095450 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3094863..3095450 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3094951..3095430 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3094951..3095430 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3095334..3095531) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3095367 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3095377) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3095436 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3095515 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3095530..3095549) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3095536) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3095558..3095565 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3095562..3095571) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3095580..3095599 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3095586 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3095624..3096241 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3095624..3096241 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3096242..3096342 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3096299 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3096368..3096377 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096389..3096404 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096390 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3096419..3096754 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3096419..3096754 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3096710..3096728) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096719) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3096743..3096748) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3096753 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3096759..3098336) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3096759..3098336) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3096798..3098509 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3098487..3098494 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3098505..3098524 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3098511 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3098550..3099026 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3098550..3099026 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3099040..3099633 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3099040..3099633 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3099630..3100166 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3099630..3100166 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3100147 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3100193..3100414) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3100193..3100414) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3100361 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3100368..3100369 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3100411..3100956) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3100411..3100956) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3100973..3100980 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3100995..3101014 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3100999 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3101079..3101960 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3101079..3101960 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3102045..3102761) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3102045..3102761) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3102065) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3102771..3103235) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3102771..3103235) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3103225..3105033) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3103225..3105033) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3105052..3105312) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3105052..3105312) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3105322..3105744) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3105322..3105744) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3105745..3105827) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3105819..3105838) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3105827) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3105851..3105858) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3105961..3106086) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3105961..3106086) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3106004..3106135) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3106047) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3106136..3106921) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3106136..3106921) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3106922..3107037) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3107030..3107049) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107037) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107063..3107070) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3107113..3108435) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3107113..3108435) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3107125) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3108469) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3108471..3108596) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3108471..3108489) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3108505..3108510) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3108576..3108595) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3108596) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3108630..3109394) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3108630..3109394) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3109413) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3109447..3110160) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3109447..3110160) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3109464) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3110150..3110896) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3110150..3110896) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3110928..3110947) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3110940) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3110964..3110967) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3111130..3111273) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3111130..3111273) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3111151) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3111274..3111359) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3111349..3111360) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3111359) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3111361..3111591) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3111398..3111402 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111418..3111437 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111427 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3111477..3113087 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3111477..3113087 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3111579..3111597) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111591) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3111593..3111767) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3111611..3111618) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3111754..3111773) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3111767) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3111787..3111795) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3113074..3115842 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3113074..3115842 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3115891) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3115968..3116825) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3115968..3116825) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3116831..3117607) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3116831..3117607) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3117633..3117652) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3117655) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3117657..3117729) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3117667..3117674) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3117731..3117830) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3117774) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3117831..3118172) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3117831..3118172) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3118194..3118213) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118213) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3118227..3118234) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3118249..3118632) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3118249..3118632) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3118654..3118673) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3118661..3118680 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3118665 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3118674) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3118688..3118695) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3118755..3118774 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3118758 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3118807) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3118807..3119217 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3118807..3119217 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3119218..3119301 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3119259 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3119357..3119665) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3119357..3119665) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3119358) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3120009..3120845 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3120009..3120845 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3120225..3120232 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3120247..3120266 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3120250 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3120844 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3120892..3121284) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3120892..3121284) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3120898) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3121357..3121782) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3121357..3121782) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3121843..3121862) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121859) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3121861..3121945) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3121877..3121884) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3121924 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3121927..3121946 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3121937..3121956) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3121945) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3121947..3123031) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3121970..3121975) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3121974..3123038 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3121974..3123038 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3123039..3123923 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3123061..3123870) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3123061..3123870) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3123076) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3123904..3124716) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3123904..3124716) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3124717..3124796) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3124747..3124754 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124768..3124787 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124777 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3124790..3124808) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3124796) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3124822..3124829) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3124879..3125880) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3124879..3125880) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3124885) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3125935..3125954) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3125959) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3125961..3126045) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3126046..3126327) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3126046..3126327) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3126342..3126452) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3126342..3126452) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3126483..3126501) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3126505) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3126517..3126522) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3126598..3126604 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3126618..3126637 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3126634 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3126677..3127090 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3126677..3127090 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3127112..3128302 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3127112..3128302 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3128393..3129799) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3128393..3129799) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3128690) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3129832..3129851) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3129850) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3129866..3129869) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3129905..3131377) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3129905..3131377) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3131558..3132916) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3131558..3132916) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3131572) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3132916..3133485) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3132916..3133485) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3133504..3133515) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3133522) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3133529..3133535) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3133592..3133759) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3133592..3133759) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3133669..3134133) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3133669..3134133) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3134163..3134182) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3134168) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3134196..3134203) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3134334..3134337 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3134352..3134371 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3134356 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3134415..3135629 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3134415..3135629 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3135245..3135263) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135246) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3135277..3135284) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3135495..3135501 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3135515..3135534 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3135517 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3135641..3135991 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3135641..3135991 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3135984 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3136043..3136051 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3136065..3136073 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3136072 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3136114..3136123 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3136136..3136151 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3136140 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3136172..3136753 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3136172..3136753 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3136270..3136289) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3136280) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3136303..3136311) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3136734 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3136794..3137216) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3136794..3137216) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3136813) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3137251..3137266) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137270) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3137279..3137288) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3137327..3138178) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3137327..3138178) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3137336) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3137578) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3137815..3137817 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137834..3137853 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3137835..3138181 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3137835 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3138173..3138176 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3138183..3138318 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3138183 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3138212) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3138218..3138227) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3138319..3138810 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3138319..3138810 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3138548..3138553 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3138569..3138587 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3138580 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3138671..3139579) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3138807..3139325 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3138807..3139325 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3139130 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3139328 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3139484..3139615 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3139484..3139615 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3139612..3140046) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3139612..3140046) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3139624) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3140095..3140114) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140102) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3140104..3140401) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3140129..3140136) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3140175..3140179 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3140196..3140215 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3140208..3140288 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3140209 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3140289..3141737 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3140289..3141737 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3140401) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3140402..3140420) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3140403..3140746) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3140436..3140442) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3140724..3140742) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140746) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140758..3140763) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3141726 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3141758..3142531) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3141758..3142531) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3141780) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3142606..3142609 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3142625..3142644 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3142629 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3142676..3143059 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3142676..3143059 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3143046 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3143094..3143735) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3143094..3143735) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3143144) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3143803..3144204) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3143803..3144204) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3144253..3144272) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144263) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3144265..3144338) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3144287..3144292) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144339..3146048) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3144339..3146048) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3146045..3146419) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3146045..3146419) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3146416..3146733) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3146416..3146733) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3146734..3146818) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3146818) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3146820..3146833) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3146820..3146913) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3146914..3147078) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3146914..3147078) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3147001..3147019) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3147013) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3147031..3147039) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3147079..3147250) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3147251..3147433) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3147251..3147433) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3147434..3147580) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3147568..3147587) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3147580) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3147582..3147696) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3147602..3147609) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3147683,3147685) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3147710 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3147713..3147717 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3147730..3147918) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3147730..3147918) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3147741) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3147908 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3147944..3147962) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3147955) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3147976..3147982) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3147991..3148491) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3147991..3148491) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3148527..3148546) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3148534) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3148560..3148566) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3148626..3149759) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3148626..3149759) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3148644) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3149786..3149805) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3149793) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3149856..3149874) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3149872) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3149888..3149895) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3149951..3150976) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3149951..3150976) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3149964) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3150992..3151780) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3150992..3151780) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3151806..3151825) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3151812) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3151814..3152025) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3151839..3151846) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3152026..3152187) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3152026..3152187) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3152200..3152218) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3152220) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3152232..3152238) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3152281..3152955) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3152281..3152955) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3152296) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3153008..3153148) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3153008..3153148) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3153279..3153962) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3153279..3153962) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3154339..3154343 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3154348..3155379) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3154348..3155379) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3154358..3154377 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3154364) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3154376 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3155407..3155425) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3155420) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3155422..3155539) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3155441..3155446) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3155481..3155486 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3155498..3158158 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3155498 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3155502..3155520 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3155575..3156885) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3155575..3156885) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3155584) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3156909..3156928) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3156916) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3156919..3157659) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3156919..3157659) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3156942..3156951) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3157290) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3157292..3157300) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3157314..3157322) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3157414..3157429) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3157422) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3157442..3157451) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3157660..3157787) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3157788..3158018) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3157788..3158018) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3158019..3158281) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3158154..3158173 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3158160 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3158188..3158661 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3158188..3158661 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3158265..3158284) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3158281) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3158283..3158666) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3158299..3158302) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3158695..3159093) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3158695..3159093) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3158711) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3159085..3159103) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159094) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159117..3159123) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3159117..3160538) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3159117..3160538) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3160564..3161427) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3160564..3161427) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3161428..3161503) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3161504..3163012) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3161504..3163012) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3163029..3163574) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3163029..3163574) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3163571..3164083) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3163571..3164083) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3164084..3164245) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3164246..3164458) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3164246..3164458) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3164504..3165238) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3164504..3165238) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3165052..3165152 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3165112 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3165246..3165629) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3165246..3165629) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3165318..3165336) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3165320) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3165630..3165900) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3165862..3165871 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3165871 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3165876..3165895) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3165885..3165904 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3165900) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3165902..3166023) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3165908..3165915) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3166052..3166681) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3166052..3166681) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3166068) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3166725..3166744) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3166748) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3166759..3166766) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3166816..3168063) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3166816..3168063) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3166839) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3168105..3168124) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168122) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3168124..3168208) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3168139..3168144) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3168253) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3168270..3168812) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3168270..3168812) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3168825..3169274) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3168825..3169274) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3169275..3169374) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3169366..3169385) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3169374) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3169399..3169406) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3169431..3169883) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3169431..3169883) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3169900..3169919) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3169918) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3169934..3169937) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3169959..3170516) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3169959..3170516) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3170543..3170561) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3170556) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3170577..3170582) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3170595..3171635) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3170595..3171635) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3170600) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3171636..3171700) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3171690..3171709) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3171700) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3171702..3171791) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3171725..3171729) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3171792..3172235) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3171792..3172235) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3172302..3172976) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3172302..3172976) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3172738..3172756) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3172745) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3172771..3172777) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3173008..3173025) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3173009) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3173041..3173046) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3173082 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3173086..3173105 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3173117..3173479 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3173117..3173479 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3173492) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3173496..3173783) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3173496..3173783) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3173784..3173842) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3173840..3173859) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3173843..3174709) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3173843..3174709) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3173856) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3173872..3173881) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3174711..3175781) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3174711..3175781) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3174714) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3175782 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3175809..3175828) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3175833) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3175835..3175946) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3175842..3175848) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3175878..3175897 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3175892 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3175907..3176293 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3175907..3176293 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3175928..3175946) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3175946) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3175960..3175967) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3176361..3176369 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3176380..3176398 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3176381 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3176415..3176969 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3176415..3176969 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3176899..3176903 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3176904 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3176948 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3177003..3177962) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3177003..3177962) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3177025) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3178000..3178018) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178014) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178033..3178039) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3178044..3179792) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3178044..3179792) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3178518..3178536) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178526) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3178551..3178557) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3179793..3179883) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3179867..3179886) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3179883) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3179900..3179907) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3180026) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3180031..3180618) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3180031..3180618) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3180707..3180907) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3180707..3180907) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3180720) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3180908..3180985) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3180981..3181000) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3180985) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181014..3181021) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3181026..3182309) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3181026..3182309) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3182310..3182612) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3182340..3182501) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3182340..3182501) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3182592..3182611) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182612) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3182627..3182631) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182716..3183681) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3182716..3183681) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3182722) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3183298..3183307 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3183320..3183339 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3183328 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3183712..3185001) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3183712..3185001) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3185002..3185361) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3185380..3186018) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3185380..3186018) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3185406) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3186019..3186137) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3186138..3186995) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3186138..3186995) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3186996..3187122) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3187104..3187123) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3187122) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3187137..3187144) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3187176..3187550) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3187176..3187550) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3187590..3187608) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3187604) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3187606..3188245) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3187607..3187610 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3187619..3187627) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3187626..3187645 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187639 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3187653..3187658 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187674..3187693 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187684 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3187716..3188237 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3187716..3188237 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3188180..3188183 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3188198..3188217 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3188212 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3188235..3188254) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3188245) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3188256 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3188269..3188276) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3188319..3189926) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3188319..3189926) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3188332) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3189927..3190114) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3190102..3190121) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190114) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3190136..3190143) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3190168..3190689) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3190168..3190689) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3190224) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3190690..3190792) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3190773..3190792) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190792) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3190794..3190871) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3190808..3190811) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3190872..3192011) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3190872..3192011) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3192008..3194125) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3192008..3194125) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3194126..3194184) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3194185..3194204) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3194198) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3194218..3194225) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3194224..3194230 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3194244..3194255 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3194249 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3194280..3195476 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3194280..3195476 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3194472..3195350) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3195340..3195358) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195351) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3195374..3195379) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3195489..3196451 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3195489..3196451 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3196465..3196471 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3196486..3196504 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3196486 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3196532..3196804 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3196532..3196804 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3196538) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3196794 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3196839..3197245 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3196846..3197370) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3196846..3197370) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3196868) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3197380..3199107) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3197380..3199107) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3199141..3199160) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3199155) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3199174..3199180) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3199196..3200698) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3199196..3200698) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3200722..3200740) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200740) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3200755..3200761) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3200785..3201157) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3200828) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3201184..3201855) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3201184..3201855) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3201202) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3201852..3202406) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3201852..3202406) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3202432..3203895) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3202432..3203895) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3203885..3207571) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3203885..3207571) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3207602..3207621) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3207626) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3207628..3207757) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3207767..3208243) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3207767..3208243) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3207802) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3208266..3208285) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3208278) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3208300..3208303) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3208350 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3208353..3208372 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3208387..3209106 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3208387..3209106 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3209090 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3209138..3209854) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3209138..3209854) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3209140) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3209210) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3209880..3209899) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3209892) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3209953..3211140) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3209953..3211140) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3211170..3211189) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3211188) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3211276..3212946) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3211276..3212946) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3211278) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3212943..3213371) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3212943..3213371) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3213439..3213453 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3213439..3213458) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213446 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3213455) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3213475..3213478) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3213510..3213529) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3213522) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3213551,3213558) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3213552..3213557 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3213558..3216036 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3213559..3214935) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3213559..3214935) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3214974..3216329) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3214974..3216329) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3216365..3216384) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3216383) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3216397..3216406) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3216509..3216528 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3216510 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3216555) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3216559..3217704 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3216559..3217704 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3217563..3217567 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3217584..3217603 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3217591 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3217674) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3217688..3217807 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3217688..3217807 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3217792 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3217837..3217905 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3217906..3218379 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3217906..3218379 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3218368 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3218411..3219283) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3218411..3219283) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3218422) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3218488) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3219344..3220174) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3219344..3220174) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3220175..3220270) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3220258..3220277) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3220269) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3220290..3220297) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3220315..3220320 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3220336..3220354 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3220338 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3220376..3222451 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3220376..3222451 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3222504) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3222628..3222743) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3222671) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3222744..3223262) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3222744..3223262) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3223276..3223935) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3223276..3223935) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3223958..3223961 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3223971..3223990) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3223976..3223995 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3223979 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3223989) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3223991..3224274) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3224005..3224012) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3224044..3224232 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3224044..3224232 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3224221 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3224275..3224694) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3224275..3224694) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3224744..3224763) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224755) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224778..3224785) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3224814..3226730) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3224814..3226730) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3226008..3226026) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3226013) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3226043..3226047) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3226761) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3226784..3227005) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3226784..3227005) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3227037..3227258) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3227037..3227258) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3227290..3227552) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3227301 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3227333) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3227340..3227495) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3227340..3227495) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3227502..3227505 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3227514..3227527 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3227521 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3227529..3227548) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227552) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3227562..3227568) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3227575..3228975) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3227575..3228975) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3228975..3229445) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3228975..3229445) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3229401) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229557..3230057) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3229557..3230057) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3229560) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3230093..3231394) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3230093..3231394) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3231418..3231437) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231432) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3231434..3231555) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3231453..3231455) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3231556..3231780) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3231556..3231780) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3231781..3231865) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3231854..3231873) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3231864) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3231888..3231891) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3231931..3231937 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3231952..3231963 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3231953 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3231995..3232771 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3231995..3232771 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3232757 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3232859..3232866 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3232881..3232900 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3232885..3237111 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3232885 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3232915..3233805) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3232915..3233805) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3233805..3233905) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3233845) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3233973..3234818) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3233973..3234818) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3234136) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3234867..3235766) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3234867..3235766) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3235809..3235828) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235812) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3235842..3235849) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3235913) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3235913..3236884) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3235913..3236884) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3236919..3236938) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236944) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236954..3236958) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3237032..3237043) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3237035) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3237057..3237063) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3237106..3237125 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3237113 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3237154..3237918 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3237154..3237918 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3237905 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3237925,3237932) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3237926..3237931 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3237932..3237984 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3237934..3239172) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3237934..3239172) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3239214..3239233) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3239226) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3239245..3239252) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3239382..3240794) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3239382..3240794) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3239389) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3240794..3242494) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3240794..3242494) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3241463..3241479) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3241475) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3242568..3244115) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3242568..3244115) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3242575) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3244159) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3244161..3244341) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3244162..3244180) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3244342..3245616) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3244342..3245616) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3245617..3245699) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3245699) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3245712..3245730) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3245792) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3245793..3246257) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3245793..3246257) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3246258..3246368) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3246350..3246369) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3246368) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3246384..3246391) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3246579) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3246581..3247036) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3246581..3247036) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3246671..3246690 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3246679 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3247029..3247880) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3247029..3247880) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3247894..3248841) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3247894..3248841) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3248841..3249581) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3248841..3249581) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3249599..3249604 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3249605 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3249606..3250625) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3249606..3250625) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3249619..3249637 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3250489..3250498 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3250511..3250526 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3250522 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3250628..3251350) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3250628..3251350) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3251343..3252464) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3251343..3252464) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3252464..3253333) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3252464..3253333) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3253334..3254503) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3253334..3254503) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3254524..3255948) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3254524..3255948) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3255953..3256723) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3255953..3256723) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3256758..3256777) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3256772) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3256791..3256800) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3256891..3256896 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256912..3256930 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3256914..3257042 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3256914 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3257043..3257588 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3257043..3257588 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3257574 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3257632..3258003) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3257632..3258003) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3257650) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3258065..3259387) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3258065..3259387) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3259407..3259724) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3259407..3259724) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3259753..3259772) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259764) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3259786..3259792) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3259827..3259834 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3259850..3259869 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3259853 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3259892..3261262 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3259892..3261262 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3261287..3261964) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3261287..3261964) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3261301) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3261791..3261810) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3261807) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3261826..3261831) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3261978..3262784) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3261978..3262784) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3262277..3262295) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262291) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3262310..3262316) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3262813..3262832) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3262819) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3262848..3262855) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3262874..3263407) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3262874..3263407) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3263455..3264090) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3263455..3264090) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3264083..3264421) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3264083..3264421) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3264443..3264462) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3264454) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3264477..3264484) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3264505..3264508 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3264523..3264542 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3264523 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3264565..3265380 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3264565..3265380 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3265359 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3265435) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3265470..3265718) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3265470..3265718) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3265490) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3265736) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3265738..3265811) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3265746..3265752) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3265812..3267251) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3265812..3267251) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3267248..3268633) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3267248..3268633) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3268652..3268661) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3268666) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3268668..3268732) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3268711..3268728) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268732) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268744..3268751) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3268774..3268793) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3268792) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3268807..3268814) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3268873..3268876 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3268883 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3268891..3268910 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3268935..3269705 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3268935..3269705 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3269706..3270773 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3269744..3270574) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3269744..3270574) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3269745) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3270600..3270619) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270606) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3270614..3270916) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3270614..3270916) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3270634..3270641) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3270917..3271055) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3271040..3271059) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3271055) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3271370..3271378 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3271389..3271407 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3271390 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3271446..3271523 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3271446..3271523 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3271456..3271457 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3271459..3272460) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3271459..3272460) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3272461..3272622) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3272634..3273383) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3272634..3273383) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3272667) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3273401..3273420) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273418) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273435..3273438) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3273489..3274670) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3273489..3274670) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3273503) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3274671..3274802) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3274796..3274811) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3274802) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3274823..3274832) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3275037..3275044 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3275055..3275165 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3275055..3275074 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275055 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3275166..3275429 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3275166..3275429 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3275319 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3275435 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3275472..3275846) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3275472..3275846) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3275483) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3275848..3276462) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3275848..3276462) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3276476..3278425) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3276476..3278425) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3277689..3277708 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3277695 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3278119..3278219 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3278179 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3278289 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3278453..3279418) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3278453..3279418) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3279419..3279487) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3279474..3279493) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279487) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3279489..3279674) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3279506..3279510) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3279605..3279610 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3279626..3279644 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279631 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3279665..3279684) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279674) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3279676..3279785) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3279699..3279703) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3279741 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3279770..3279789) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279785) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279805..3279809) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3279863..3279881) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3279868..3279874 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3279880) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3279889..3279907 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3279892 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279897..3279902) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3279934..3280179 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3279934..3280179 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3280161 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3280250..3281791) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3280250..3281791) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3280279) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3281795..3282967) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3281795..3282967) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3282985..3283003) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3283007) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3283018..3283024) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3283048..3283431) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3283048..3283431) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3283449..3284120) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3283449..3284120) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3284142..3284161) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284151) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284177..3284180) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3284261..3284264 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3284279..3284298 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3284288..3284475 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3284288 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3284476..3284634 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3284476..3284634 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3284635..3285019 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3285000..3285005 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3285021..3285039 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3285021 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3285077..3285385 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3285077..3285385 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3285163) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3285167..3285267) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3285207) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3285382..3286923 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3285382..3286923 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3286914 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3286954..3287556) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3286954..3287556) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3286968) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3287557..3287838) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3287839..3289089) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3287839..3289089) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3287935) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3289108..3290265) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3289108..3290265) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3289181..3289200) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3289208) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3290262..3291707) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3290262..3291707) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3291741..3291760) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3291751) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3291774..3291781) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3291864..3292532) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3291864..3292532) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3291873) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3292529..3293347) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3292529..3293347) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3293355..3294260) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3293355..3294260) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3293995..3294014) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3294006) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3294301..3294320) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3294311..3294318 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3294322) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3294330 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3294332..3294351 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3294336..3294343) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3294366..3294752 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3294366..3294752 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3294734..3295411 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3294734..3295411 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3295383 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3295455..3295462 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3295473 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3295476..3295495 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3295515..3296714 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3295515..3296714 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3296748..3296945 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3296748..3296945 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3296924 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3296980..3298170) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3296980..3298170) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3296995) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3297079) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3298194..3298213) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3298210) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3298230..3298237 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3298246 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3298251..3298270 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3298291..3298671 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3298291..3298671 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3298569 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3298640 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" downshifts complement(3298716) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3298731..3298732 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_020" promotor_-35 <3298732..3298735 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3298750..3298769 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3298769 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3298981..3298988 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3299001..3299020 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3299001 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3299053..3300432 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3299053..3300432 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3300141..3301344) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3300486..3301328 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3300486..3301328 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3301379..3302239) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3301379..3302239) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3301389) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3302223 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3302261..3302279) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302279) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302294..3302300) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302349..3303062) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3302349..3303062) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3302464..3302465 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3302485..3302502 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3302487 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3303090..3303101) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3303091) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3303116..3303122) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3303137..3303143 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3303158..3303177 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3303168 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3303213..3303728 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3303213..3303728 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3303729..3303935 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3303729..3303935 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3303895 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3303977..3305218 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3303977..3305218 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3305309..3305317 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3305328..3305346 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3305339 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3305374..3306741 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3305374..3306741 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3306718 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3306771..3307403) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3306771..3307403) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3306789) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3307439..3307454) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3307447) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3307467..3307475) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3307545..3308480) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3307545..3308480) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3307557) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3308224..3308233 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3308247..3308266 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3308251 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3308481..3308568) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3308551..3308570) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308568) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3308586..3308590) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3308613..3308625) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308613) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3308640..3308646) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3308643..3308777) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3308643..3308777) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3308724..3308731 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3308745..3308764 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3308754 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3308757..3308861 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3308856..3308865 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3308863 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3308877..3308892 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3308899) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3308901..3308915) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3308927..3309076 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3308927..3309076 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3309094..3310605 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3309094..3310605 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3310602..3311789 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3310602..3311789 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3311806..3312042 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3311806..3312042 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3312042..3313220 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3312042..3313220 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3313221..3313310 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3313311..3314069 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3313311..3314069 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3314037 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3314071..3315298) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3314117..3314124 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314138..3314157 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314151 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3314210..3315301 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3314210..3315301 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3315203 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3315291 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3315335..3316663) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3315335..3316663) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3315343) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3316660..3316992) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3316660..3316992) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3317011..3318369) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3317011..3318369) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3318385..3318693) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3318385..3318693) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3318738..3318757) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318754) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3318771..3318777) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3318822) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3318822..3320747) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3318822..3320747) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3319485..3319494 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3319508..3319527 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3319516 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3320820..3320837) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3320844) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3320852..3320859) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3320910..3321068) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3320910..3321068) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3320937) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3321097..3321687) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3321097..3321687) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3321715..3321733) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3321726) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3321747..3321753) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3321756..3321762 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3321778..3321796 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3321781 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3321816..3323459 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3321816..3323459 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3321953..3323502) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3323454 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3323504..3323595) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3323506..3323512 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3323520 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3323527..3323546 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3323547) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3323564..3324766 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3323564..3324766 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3323597..3324762) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3323640) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3324763..3325539) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3324763..3325539) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3325536..3326423) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3325536..3326423) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3326430..3326618) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3326430..3326618) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3326615..3326821) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3326615..3326821) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3326818..3327138) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3326818..3327138) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3326951..3326960 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3326973..3326992 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3326975 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3327131..3327667) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3327131..3327667) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3327695) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3327696..3327711) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3327723..3327732) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3327798..3327805 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3327819..3327838 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3327828 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3327879..3329252 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3327879..3329252 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3328159..3328701) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3328689..3328708) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3328701) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3328723..3328730) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3329087 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3329267..3330097) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3329267..3330097) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3329273) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3330116..3330134) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3330131) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3330149..3330155) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3330175) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3330177..3330196) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3330183..3331910) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3330183..3331910) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3330282) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3331907..3333610) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3331907..3333610) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3333610..3334626) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3333610..3334626) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3334500..3334518) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3334509) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3334534..3334539) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3334610..3336016) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3334610..3336016) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3336017..3336225) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3336208..3336227) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336225) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3336227..3336335) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3336241..3336246) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3336332..3336351) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3336347) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3336365..3336372) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3336493..3336500 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3336510 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3336515..3336533 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3336572..3337924 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3336572..3337924 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3337523..3340005) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3337909 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3338000..3338019 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3338006 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3338046..3339734 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3338046..3339734 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3339732..3339741 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339753..3339768 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3339757 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3339792..3339992 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3339792..3339992 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3339993..3340937 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3340006..3340845) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3340006..3340845) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3340871..3340889) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3340889) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3340902..3340909) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3340904 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3340952..3342049) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3340952..3342049) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3340953) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3342082..3342101) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3342099) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3342101..3342169) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3342114..3342121) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3342170..3343063) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3342170..3343063) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3343090..3343109) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343109) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343123..3343130) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3343137..3343142 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343158..3343176 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343167 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3343184..3343190 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3343205..3343223 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3343211 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3343247..3344704 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3343247..3344704 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3344130..3344148) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3344145) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3344163..3344168) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3344685 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3344729 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3344746..3345582) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3344746..3345582) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3344764) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3345659..3345761) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3345659..3345761) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3345685) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3345787..3345806) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345798) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3345800..3346541) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3345820..3345826) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3345878..3345885 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345898..3345916 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345907 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3345917..3346002 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3345978..3345985 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345999..3346018 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3346004 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3346150..3346692 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3346150..3346692 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3346517..3346536) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3346541) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3346550..3346559) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3346682 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3346727..3347049 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3346767..3347786) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3346767..3347786) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3346785) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3347812..3347831) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3347826) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3347846..3347849) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3347901..3348407) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3347901..3348407) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3348413..3348432) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348435) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3348437..3348440 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3348446..3348452) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3348455..3348474 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3348458 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3348537..3349412 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3348537..3349412 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3348787..3348875) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3348809) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3348835..3348935) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3348875) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3349490..3349963 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3349490..3349963 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3349981..3351201 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3349981..3351201 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3351188..3351844 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3351188..3351844 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3351842..3351847 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3351861..3351880 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3351864 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3351894..3353126 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3351894..3353126 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3351911) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3353111 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3353172..3353181 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3353194..3353209 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3353196..3353418 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3353196 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3353375 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3353429..3353435 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3353448..3353548 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3353448 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3353450..3353468 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3353527..3353534 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3353548..3353566 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3353550..3353647 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3353550 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3353648..3353911 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3353648..3353911 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3353675..3353678 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3353693..3353712 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3353705 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3353859 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3353903 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3353978..3353987 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3353993 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3353999..3354014 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3354040..3354528 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3354040..3354528 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3354533..3354540 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354554..3354573 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3354564 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3354594..3354700 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3354594..3354700 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3354695 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3354783..3355916 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3354783..3355916 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3355056..3355299) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3355294..3355313) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3355303) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3355328..3355335) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3355922..3355929 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3355944..3355963 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3355950 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3355985..3356091 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3355985..3356091 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3356038 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3356092..3356168 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3356169..3357305 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3356169..3357305 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3357292 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3357358..3358131) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3357358..3358131) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3357368) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3358148..3358798) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3358148..3358798) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3358795..3359511) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3358795..3359511) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3359535..3360953) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3359535..3360953) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3360121..3360139) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3360140) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3360155..3360160) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3360954..3361038) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3361022..3361040) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361038) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361056..3361061) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3361107..3361955) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3361107..3361955) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3361117) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3361956..3362141) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3362130..3362149) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362141) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3362143..3362868) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3362165..3362169) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3362303..3362310 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3362323..3362342 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3362332 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3362342..3362444 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3362342..3362444 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3362445..3362548 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3362520..3362526 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3362540..3362551 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3362550 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3362571..3363764 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3362571..3363764 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3362855..3362873) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362871) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3362886..3362893) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3363540 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3363760 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3363806..3364234) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3363806..3364234) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3364235..3364477) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3364235..3364477) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3364478..3364541) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3364530..3364545) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364541) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3364557..3364566) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3364574 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3364622..3364912) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3364622..3364912) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3364628) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3364937..3364956) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3364954) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3364962..3367022) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3364962..3367022) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3364970..3364977) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3367051..3367069) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367055) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3367084..3367090) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3367115..3367120 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3367134 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3367136..3367154 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3367148..3367222 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3367223..3368503 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3367223..3368503 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3368504..3368643 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3368600 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3368661..3369389) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3368661..3369389) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3368678) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3369420..3369439) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369431) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3369453..3369460) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3369577..3369684) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3369620) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3369685..3370518) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3369685..3370518) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3370549..3370568) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370568) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3370582..3370589) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3370614..3371294) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3370614..3371294) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3371341..3371360) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3371350) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3371374..3371381) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3371442..3371445 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3371460..3371479 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3371460 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3371501..3372787 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3371501..3372787 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3372232..3372250) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3372240) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3372264..3372271) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3372758 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3372806..3374245) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3372806..3374245) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3372829) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3374269..3374288) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3374286) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3374327..3375475) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3374327..3375475) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3375502..3375518) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375518) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3375520..3375604) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3375533..3375538) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3375605..3375793) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3375605..3375793) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3375824..3375955) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3375824..3375955) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3375967..3376428) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3375967..3376428) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3376444..3376740) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3376444..3376740) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3376768..3377256) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3376768..3377256) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3377274..3377726) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3377274..3377726) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3377727..3377795) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3377796..3378125) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3377796..3378125) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3378126..3378247) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3378248..3378664) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3378248..3378664) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3378715..3379083) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3378715..3379083) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3379077..3379547) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3379077..3379547) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3379548..3379872) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3379873..3380301) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3379873..3380301) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3380363..3387367) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3380363..3387367) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3387374..3387388 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3387388 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3387398..3387417) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387413) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387432..3387439) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3387529..3388464) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3387529..3388464) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3387750) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3388465..3388585) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3388616..3389062) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3388616..3389062) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3388630) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3389099..3389118) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3389106) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3389132..3389139) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3389165..3390574) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3389165..3390574) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3390597..3392426) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3390597..3392426) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3392418..3392518) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3392458) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3392460..3392652) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3392633..3392652) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3392652) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3392654..3392787) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3392665..3392672) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3392809..3393117) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3392809..3393117) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3392832) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3393163..3393606) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3393163..3393606) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3393603..3395312) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3393603..3395312) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3394474..3394493) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3394482) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3395332..3395601) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3395332..3395601) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3395613..3395978) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3395613..3395978) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3395979..3396044) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3396031..3396050) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3396044) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3396065..3396068) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3396285..3397694) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3396285..3397694) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3396308) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3397695..3397804) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3397828..3397992) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3397828..3397992) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3397877..3397895) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3397892) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3397906..3397914) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3398184..3398203) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3398200) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3398216..3398223) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3398232..3398239 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3398254..3398273 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3398257 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3398311..3398757 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3398311..3398757 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3398762 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3398870..3400396 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3398870..3400396 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3400393..3402051 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3400393..3402051 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3402064..3403329 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3402064..3403329 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3403322..3404281 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3403322..3404281 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3404282..3404356 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3404357..3405784 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3404357..3405784 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3405780 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3405828..3407129) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3405828..3407129) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3405845) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3407159..3408340) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3407159..3408340) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3408341..3408420) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3408421..3409092) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3408421..3409092) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3409041..3409044 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3409059 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3409060..3409079 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3409120..3409139) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409135) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3409153..3409160) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3409198..3410139) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3409198..3410139) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3410184..3410203) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410190) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3410192..3410272) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3410219..3410222) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3410288..3410289 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3410385..3410391 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3410407..3410425 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3410417 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3410479..3411864 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3410479..3411864 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3411850 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3411895..3412445 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3411906..3413786) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3411906..3413786) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3411912) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3413787..3413884) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3413875..3413894) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413884) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413909..3413916) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3413954..3414205) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3413954..3414205) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3413972) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3414227..3414246) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3414236) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3414269..3414275 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3414289..3414307 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3414290 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3414322..3415143 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3414322..3415143 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3415127 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3415172..3416314) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3415172..3416314) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3415182) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3416315..3416414) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3416402..3416421) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3416413) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3416435..3416442) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3416457..3417794 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3416457..3417794 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3417199..3417799) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3417833..3418312) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3417833..3418312) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3417844) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3418392..3419384) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3418392..3419384) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3418416) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3419374 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3419407..3419426) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3419425) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3419441..3419448) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3419447..3419454 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3419468..3419892 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3419468 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3419469..3419488 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3419474..3419886 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3419474..3419886 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3419494) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3419504..3419518) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3419526..3419530) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3419858 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3419893..3420627 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3419893..3420627 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3420627..3420896 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3420627..3420896 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3420900..3421382 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3420900..3421382 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3421403..3423646 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3421403..3423646 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3423643..3424842 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3423643..3424842 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3424598..3424616) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424620) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3424631..3424637) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3424833 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3424906) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3424906..3426138) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3424906..3426138) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3426170..3426189) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3426182) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3426203..3426208) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3426239..3426664) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3426239..3426664) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3426692..3426711) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3426706) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3426724..3426730) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3426856..3426863 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3426873 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3426878..3426897 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3426921..3427376 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3426921..3427376 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3427314 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3427377..3427990 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3427406..3428614) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3427406..3428614) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3427433) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3428615..3428721) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3428722..3429735) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3428722..3429735) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3429736..3429809) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3429794..3429813) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3429809) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3429826..3429833) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3429829..3430404) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3429829..3430404) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3429853) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3430433..3430452) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430447) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3430467..3430474) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3430475..3430481 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3430496..3430514 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3430503 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3430535..3431605 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3430535..3431605 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3431603 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3431662..3432093) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3431662..3432093) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3432123..3432130 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3432144..3432163 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3432153..3432319 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3432153 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3432205..3432224) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432225) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3432239..3432246) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3432320..3432724 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3432320..3432724 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3432341..3433393) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3432694..3433386 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3432694..3433386 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3433426..3434457) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3433426..3434457) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3433438) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3434424..3434427 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3434440 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3434444..3434463 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3434494..3434512) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434512) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434527..3434533) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3434550..3435698) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3434550..3435698) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3435737..3435756) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3435748) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3435767..3435774) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3435820..3435827 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3435841..3435860 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3435848 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3435894..3436625 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3435894..3436625 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3436618..3438159 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3436618..3438159 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3438188..3439534 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3438188..3439534 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3438987..3438991 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3439007..3439026 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3439016 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3439557..3440963 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3439557..3440963 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3440952 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3441060..3441079 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3441062..3441353 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3441062 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3441326..3441333 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3441348..3441367 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3441355 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3441377..3441384 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3441399..3441418 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441402) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3441405..3441419) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3441414 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3441427..3441431) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3441427..3441990 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3441427..3441990 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3442004..3443533 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3442004..3443533 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3443360) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3443526 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3443559..3443642) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3443602) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3443643..3445082) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3443643..3445082) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3445096..3445326) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3445096..3445326) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3445327..3445538) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3445535..3445554) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445540) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445569..3445576) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3445602..3445609 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3445620..3445639 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3445635 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3445670..3446380 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3445670..3446380 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3446408..3446566 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3446408..3446566 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3446643 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3446697..3447419) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3446697..3447419) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3446709) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3447320..3447323 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3447339..3447343 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3447354 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3447440..3448069) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3447440..3448069) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3448070..3448218) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3448219..3448977) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3448219..3448977) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3448667..3448686) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3448683) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3448699..3448706) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3448958..3449917) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3448958..3449917) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3449906 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3449953..3449956 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3449961 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3449975..3450124) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3449975..3450124) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3449982) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3450033..3450050 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3450038 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3450119 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3450145..3450164) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3450166) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3450179..3450186) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3450459..3450466 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3450481..3450500 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3450485 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3450596..3452521 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3450596..3452521 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3452522..>3452551 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" SCAR 3452551..3452552 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs27_025" downshifts 3452561 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3452809..3453699) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3452809..3453699) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3452815) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3452877) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3453773..3455176) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3453773..3455176) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3455177..3455398) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3455399..3456604) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3455399..3456604) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3456661..3456679) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3456664) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3456774..3456779 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456794..3456813 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456809 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3456845..3458230 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3456845..3458230 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3458212..3458400) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3458212..3458400) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3458517..3458645) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3458517..3458645) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3458569 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3458665..3459867) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3458665..3459867) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3458689) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3459899..3459910) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3459899) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3459925..3459931) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3459949..3460743) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3459949..3460743) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3460765..3461607) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3460765..3461607) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3461594..3462961) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3461594..3462961) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3462188,3462190) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3462951..3464786) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3462951..3464786) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3464794..3465501) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3464794..3465501) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3465502..3465598) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3465586..3465605) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465598) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3465600..3465792) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3465621..3465624) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3465792) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3465802..3465821) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3465884) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3465885..3465957) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3465885..3465957) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3465993..3466069) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3465993..3466069) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3466070..3466150) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3466151..3466222) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3466151..3466222) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3466232..3466307) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3466232..3466307) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3466279..3466295 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3466292 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3466308..3466404) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3466388..3466407) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3466404) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3466421..3466428) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3466438..3466539) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3466478) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3466532..3467824) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3466532..3467824) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3466543) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3467864..3467883) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467884) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3467898..3467905) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3468030..3468449) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3468030..3468449) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3468447..3468458) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468458) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3468473..3468479) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3468570..3469934) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3468570..3469934) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3468590) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3468634) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3469965..3469984) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3469979) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3469999..3470001) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3470046..3470052 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3470067..3470085 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3470069 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3470104..3470304 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3470104..3470304 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3470274 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3470319..3470640 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3470352..3470555) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3470352..3470555) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3470556..3470856) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3470621..3470624 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3470639..3470658 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3470642 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3470676..3470816 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3470676..3470816 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3470817..3470888 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3470864) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3470867..3470881) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3470889..3470893) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3470889..3472097 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3470889..3472097 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3472078 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3472202..3474259 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3472202..3474259 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3474124 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3474296..3474745) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3474296..3474745) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3474310) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3474742..3476721) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3474742..3476721) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3475223..3475242) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3475226) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3475639..3475646 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3475660..3475678 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3475664..3476330 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3475664 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3476758..3477687) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3476758..3477687) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3477688..3477824) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3477806..3477825) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477824) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477840..3477845) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3477914..3478063) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3477914..3478063) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3477940) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3478102..3478121) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3478119) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3478135..3478141) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3478142..3478151 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3478164..3478183 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3478170 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3478182) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3478184..3478697) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3478186..3478200) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3478209..3478213) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3478209..3478691 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3478209..3478691 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3478678 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3478721..3479098) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3478721..3479098) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3478723..3479252 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3478742) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3479153..3479172) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479165) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3479186..3479193) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3479234..3479238 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3479252..3479271 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3479254 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3479279..3479293) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3479282) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3479303..3480232 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3479303..3480232 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3480218 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3480234..3480235 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3480237..3480791) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3480237..3480791) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3480809..3481189) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3480809..3481189) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3481245..3482180) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3481245..3482180) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3482170..3482179 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3482193..3482212 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3482200 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3482224..3482243) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3482238) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3482239..3482997) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3482239..3482997) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3482256..3482263) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3482530..3483033 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3482992 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3483062..3483301) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3483062..3483301) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3483068) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3483136) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3483345..3483863) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3483345..3483863) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3483904..3484191) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3483904..3484191) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3484192..3484258) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3484257..3484276) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3484258) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3484290..3484295) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3484302..3485402) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3484302..3485402) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3485450..3485469) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3485465) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3485484..3485491) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3485529..3487532) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3485529..3487532) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3487583..3487789) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3487583..3487789) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3487751..3487770) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3487776) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3487785..3487791) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3487815..3487834) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3487826) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3487851..3487855) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3487883..3488899) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3487883..3488899) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3488932..3488950) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3488944) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3488966..3488971) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3489075) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3489259..3489264 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3489277..3489358 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3489277 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3489280..3489298 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3489359..3489976 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3489359..3489976 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3489947..3489955 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3489966 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3489969..3489987 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3489988 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3490015..3490863) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3490015..3490863) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3490035) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3490856..3491617) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3490856..3491617) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3491651..3491670) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3491669) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3491761) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3491764..3491772) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3491786..3491794) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3491798..3491806 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3491814 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3491818..3491836 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3491865..3492305 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3491865..3492305 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3492254 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3492356..3493207) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3492356..3493207) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3492375) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3493208..3493328) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3493329..3494048) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3493329..3494048) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3494062..3495948) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3494062..3495948) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3495969..3497348) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3495969..3497348) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3497349..3497479) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3497471..3497490) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3497479) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3497506..3497510) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3497534..3497553) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3497544) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3497567..3497574) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3497634..3497640 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3497645..3499930 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3497645 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3497655..3497674 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3497659..3498285) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3497659..3498285) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3497676) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3498282..3499067) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3498282..3499067) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3499112..3499131) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499124) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3499126..3499211) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3499143..3499149) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3499212..3499562) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3499212..3499562) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3499563..3499713) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3499714..3499848) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3499714..3499848) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3499872..3499972 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3499884..3499903) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499894) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3499896..3499964) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3499919..3499926) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3499932..>3500065 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3499932 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3499950..3499969) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3499964) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3499985..3499989) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3500066..3500213 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3500089..3500362) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3500215..3500474 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcagatacaa gattcaatgc agtttgccgc ggttgaaagt ggtctgcgct 226681 tttaccaggc atatgatcaa agcctttctt tgtggccgat tgagtcggaa gcattctatg 226741 tttctactcg ttttggaaaa acacatatca ttgcaagtgg gccaaaggac gcaccttcgc 226801 tcattttgct tcacggaggc cttttcagct ctgcgatgtg gtatccgaat atcgcagcgt 226861 ggagcagtca atttcgtaca tatgcggtcg atataatagg agacaaaaat aaaagtatac 226921 catcagcagc catggaaacg agagctgatt ttgcagaatg gatgaaagat gtctttgatt 226981 ctcttggact tgagacggca catctggccg gcctttcgct tggcgggtcc catatcgtga 227041 atttcttact ccgcgcgcct gaaagagtag agcgggcggt tgttatcagt cccgctgaag 227101 cgtttatttc atttcatccg gatgtctata aatacgctgc agagcttaca ggggcaagag 227161 gagctgaatc atatatcaag tggatcacag gcgacagtta tgatctgcat cctttactgc 227221 aaagacaaat tgtggcgggc gtggaatggc aggatgagca aaggagcctg aagccgacag 227281 aaaacggctt tccgtacgtg ttcacagacc aggaattgaa atcaatacaa gtcccggtac 227341 ttctgatgtt cggtgagcac gaggctatgt accatcagca aatggccttt gagcgggctt 227401 cggtattggt gccgggaatt caggctgaaa tcgtaaagaa cgccggacat ctgttatctc 227461 tggagcagcc agagtacgtc aatcaacgcg tcttgtcctt tttatgcggg gggataaaat 227521 agtaaggaac atgaaaagat tggcattcat ttttcaaaag gtaacaaatg ttgtataata 227581 atagaatttg aatgctgctt tttttgggag cattctatgt tatcatgctt attggagaaa 227641 aatttttcct gtaacgctat tcgatcacta tcgtcaaata atatagatgg ttttacaatt 227701 ggaggtttgg ttacactgtg aattacatcc cctgtatgat tacgatagga aacttcattt 227761 gcggattgct ggcgattcat tccttgctat atcacaacat tcattcagca gtgcttttta 227821 tttttacagg catgttcctt gatttctttg acgggatggc tgctcgtaag ctgaatgccg 227881 tttctgatat ggggagagaa ctggattcgt ttgccgatct ggttacgttt ggggtggctc 227941 cttctatgct tgcttacagt gtcgcgttgt ataccctgcc atttatcggg atcttatgcg 228001 cattgacgta cagcatttgc ggaatgcttc gcctctctaa atttaacatt gaacaaagca 228061 agctcccgac gtttatcggt atgccgattc cgtttgcggg catgtgtctc gttattctaa 228121 gcttcaccta taacccgatc cttctggcaa tcggcacttg cggactctca tatttgatgg 228181 tgagtaaaat aaaattccct cattttaaaa aacatgcggc agaaaacctg gagtctggga 228241 gatggaatta gttcagcagc tcatagcgga ttacggttat ctcgctattt ttttgatgct 228301 ggtattagga attgtaggat tgccgattcc agatgaagtg atgatgaccg ttgttggcta 228361 tttcacgcat accgatgtat tgaattatga gctttcgata ttgattagtt ttgtcggggc 228421 tttgttaggt atgctgatca gctacatgat tggcagaaaa gccggacgcc cgtttatcga 228481 caagtacggc aagtgggtcg gcttaaaaga aaaaagaatg atgaaagtgg aaaaatggat 228541 gaagaaatac ggtccatatt ctcttatttt aggttatttt attcccggcg tcagacatgt 228601 gacgtgctac ttttcgggga tcggcaaaat ggatctgaaa acgtatgttg cgtttgctgc 228661 aatcggcgcc tttttatggt gctttgtttt tattacaatc ggaagggtta tagggattat 228721 tcatgtttaa tacggctgta aagattctgt atcgatcatt gatagagctg acgaatcatc 228781 gtctgtcatc ctatctgatt aaaggatttt gcgagtcgaa aatcagcaaa ccggtcattc 228841 cgcttttctc aaaacatttt cggctgaatt gggatgatgt ggacggtacg gctgctgatt 228901 acggatcgct gtccgaattg ttcattcgac aaataaatct ggagcggcgc cctgtgtcaa 228961 aagaggcgca tgcggtggtc agccctgttg acggtgtggt tcagacggta ggaatcatca 229021 acccgaatca aacctttacg gtgaagggaa aagattactc attcgctgag ctgaccggct 229081 gtaaaagcgc agaccatcaa tacaacggcg gatatttcgt cgtgctgtat ttaagcccga 229141 ggcattatca ccgtttccat tctccgatca gctgcaggta tcaaaagctg gccgagctcg 229201 gaaatcgctc atacccggta aatcaactag gcttaaaata cgggaaagat gtgctgtcga 229261 aaaattatcg gtttgtgtac gagctgaata gcggcagccg aaatgtcctg atgattcctg 229321 tcggcgcgat gaatattaat tctatcgtgc agacgaatac ccgtactgaa ttggagatcg 229381 gcgaggagct gggatacttt tcatttggct caaccgtcat tttggttttt gaaaaagacg 229441 cgttccagcc gtccgcccat ttagcagaag gccaagaagt ccaagtcgga gaactgatag 229501 gttacgaaga ataaaaagag gagcttgcat aaacgcagcg cctctttttt tgaagaaagg 229561 tgagattcat ggagaaacaa atcatcagct ggattacaga ttatcagaac accggagatg 229621 aagccgtcct gcggcaagtg cgagaagtgt gctggccgat cgttgaagcg gttttgcaag 229681 agaaagtaat ggatgatgaa caagcgaaca atttgcgcga aaaaggaatc gagcggtttc 229741 cattcatcat cagcaaatac caagcggatg tgcagcttcc ggttgagaca tttttacaaa 229801 atacgtatcg gttttacttt catcaggtga tgagagaatc cagctaaagc ttctttcaac 229861 agagaagctt ttttttgttg gcaggaaaag gaaacttttt ctatatctat ctcgtaatga 229921 ctagagaacc tagcagaaaa ggagagatag aattgaaacg aatgatagtg agaatgaccc 229981 tgccgctgct gatcgtttgt ctggcgtttt cttctttttc agcctcagcc cgtgctgctt 230041 ctgaagaaaa atattgggat cactggattg aacgacatgc acagcctctg gatgcttcca 230101 atgcttcaaa caaagacctt cgatttctaa aaaaggtgct gaagggaaaa cgaatcgttc 230161 agttaggaga aaccacacac ggtgctggcg aaatcaatgc cacaaaggtc agaatgatca 230221 aatacctcca cgaagagctg ggatacgatg tattggcctt tgaatccggc tttcctgata 230281 caaatgcatc ctaccttaat atggaccaat taacccctaa aagcacgatg aaaaactcca 230341 tttacgctgt atggcacaca gaagatgtcg tcgaattgtt tgattacatg aaagagcaaa 230401 aagagaaagg cgatccgctg atccttaccg gttttgatat tcaaagcatg aagaattcat 230461 tcaatgtagc tgcgactcaa tgggtaaaag cggtggaccc tgagaaagca gagttgctct 230521 cccaatcaga aaatgatttt tcaacattag tgacagacag caatacgttt gatgaatttt 230581 cgcaaaagaa ggaaaagctt gtgaaaaact atcagaagct gatcaagttc actaaaacac 230641 atgcttcaga gctaaaagaa aaccttccaa aagagccgaa agcttatgag atgtttatgc 230701 attctcttca gctgagaatt gacgtaatgg aaacatatat gctggaagaa atgaaagaaa 230761 aactagagga gtatccggag aatattgagg atttttcatt ctttatgaga gaccgcatga 230821 tggctgaaca atttcagtgg gtagccgaca ccctttatcc gaaaaagaaa atcattgtct 230881 ggggccacaa ttaccatcta cgcaaacaga atacgaagat gataaaggac tgggtacagc 230941 taaacggccc taacatgggt gattatttgc cggagcggct gaaaaaacaa acatatacga 231001 ttggcattta tgcttactca ggtgcgagtc ttgatagctc cgataataag actgttaagc 231061 cggttacaag cccgccgccg tctgggagcc ttgaagcttt gctgaaagcg gcggaccgac 231121 cggctgtttt tgttgatttt ctccatacaa aaaacaagaa aggcacttcg tggatgtata 231181 ccccgcggac tgcgctctat tgggggtaca tggaagagca gatgatcctg aaggaacaat 231241 atgacggtgt catttggctg gagcatatca cgccctctgt cattatcaag tgagcggtgt 231301 cccctgtggt aaacagggga tttttacata tcgcaaaaat aatcaaaaca tataatccgt 231361 gatccattat tctaaaacag aaaggagatt ggagcgtgca atgtattatg aaaaagctgt 231421 ccagaaaaca atcaattgga ttgaatcaca tttacatgag caaatatcaa acgaggatat 231481 tgttaacgtt tcaagctttt caaaattcca ttttcatcgg atttttcaaa aagaagtcgg 231541 catgtcggtt gcttcttata ttcggttaag acgtcttgcg aatgcggcgg cagctttgct 231601 ttatacagat catcgtatta tcgatattgc tttgtattat cagtttgaat ctcaagaagc 231661 atttacgagg acgttcaaaa agatgtatca catgccgcca ggagcatacc gaacatttat 231721 gaaacgcttt acttcaaaaa aggaggaatc ttacatggag aaaaaaatga aaggctgggt 231781 attgagcggg agccatccgt tccaattcga aatggggatt gaccgggaaa atgtacatca 231841 gggaaaagct tcagggtatt taaagtcaac gatggttcag gatatcggtg aatttgcgac 231901 gatgatgcag caattcaaag cagatcgcta tctaggaaaa aggcttcgtc tatcaagttt 231961 tatcaaaaca aagggggtgc agcattttgc ctcactttgg atgcgggttg acagtgctgc 232021 tgatgatgtt ctccaatttg ataatatgag caacagacct attaccggaa caaccaattg 232081 gaatcattat gctatcgttt tagatgtccc agaaaatagc gctgtgatat cttttggcgt 232141 tcaattatct gggccgggtc aggtgtggat ggatcatgtt gtttttgaag aggtagatga 232201 gagcgttcct tcaacaaacc ttgaaatgcc gggagaactt ttagatgaac cggtaaattt 232261 atcttttgaa gaggaactac aaaaatagtt ttcagacaac tacttttatt agtgagttaa 232321 tggaaaatac tatttgttat taataaaccc ttgtgctgct taggtttgta agagcttgga 232381 tatttttatc agtctgggcg gatctgttca tctttgcggc attttcctgt atgatatagt 232441 aagagtgtgc atagcaacta actataattg aacagggtgt ttaaaacatg gaaaaacaat 232501 acagagtatt actttactat aaatatgttc cgattgaaga tccagaggcg tttagagagc 232561 agcatctggc tttttgtaag gagcttggtt tgttaggccg tatccttgtt tcttctgaag 232621 gaattaacgg tacggtatca ggtacggttg aacagactga aaaatatatg gaaacaatga 232681 aagctgatcc tcgctttgcg gacatggtat ttaaaattga tgaagcagaa ggccatgcct 232741 tcaaaaaaat cttcgtccgc cataaaaaag agcttgtaac gcttcgtctt gaagatgatg 232801 tcgatccgaa cgaaacaaca ggccagcatt tgaagcctgc agaattttat gagaagatgc 232861 aggatccaaa cacaattgtc atcgacgcgc gtaacgatta cgagtatgac cttggccatt 232921 tcagaggtgc ggtccgtcct gacatcgaag ccttccgtga attacctgaa tggattgaag 232981 agcacaaaga tatgcttgaa ggcaaaaaga ttttaacgta ctgtacaggc ggcgtgcgct 233041 gtgaaaagtt ctcaggatgg ctggtgaagc aaggctttga agatgtagct cagcttgatg 233101 gcggaatcgt gacatacgga aaagatccag aggtgcaagg caagctttgg gacggccagt 233161 gctacgtatt tgatgaaaga atcagcgtgc ctgtcaaccg tgtcgagcat gtgattgtcg 233221 gcaaggacta ctttacagga gaaccgtgtg agcgttatgt gaactgcgca aatccatctt 233281 gcaataaaaa aatgatatgc acaccggaaa atgagtataa atatatgcgc agctgcagcc 233341 acgaatgccg cacgaaccca agaaacctgt atgtgaaaga gcataatatg acagaagaag 233401 aagtaaacgc aagactggca gcgattgaaa cagaagatca cgctgctgct gaataaaaaa 233461 agaacacctc gtattgaggt gttctttttt tctatatgct ttcagtttgg ctgtttgcgg 233521 aaacccattc tttttggcgg aaggcctttt cccattttga taccacgata caggcgatcg 233581 catgtcccgg tacgttcacg cctgttctcg ccatgtccat gacgcggtca acacccgcga 233641 taatggcaac gccttcagcc ggcagtccta cagcattggc agtcgccaga agaactacaa 233701 gcgatcctga gggtacagct gcaatgcctt tactggtcat cacaagcaca agcatcatga 233761 gcagctgctg ggacaatgtc atgtctactt gaaaggcctg tgcgagaaag atacaagaaa 233821 ccgataaata taagctggag ccgtcacagt tcaatgacaa gccggaggga acgacaaatg 233881 ataccactcg tttgggacag ccgtatttct ccattctatc catcagctga gggagaatgg 233941 tttcagtgct tgtggtggaa aatgcaatta aaaacagatc ccatatcatt ttcaatactt 234001 cgaaatactt aatctgaaag atgagaccga caagcggaaa gaggacaaag aggatcagga 234061 acaggccaag gaatacggtg ccaaccagct taaacatagg gaggaggagt tcaatgccat 234121 attggcctac agaagcagcc atcagggcta acacgccgat aggagcagtg accatgacga 234181 tttgcgtgag cttgaacata atctgagctg tagattcaaa aaacttcatt actggttcag 234241 aagctttgcc gataccagct gcggcgacac caaataaaat ggcgaagaaa ataacggcaa 234301 gcaaatcatt tctggccatg acatcaataa tgtttgtagg gataatatcc aggatcattt 234361 gcttgaaatc aacaactttg tctgtgtagc cggaaagttc atgaatatct ttttttgcca 234421 aatgggagag gtcaagcccg acacctggtt ttaagacatt cgctaataaa agtccaagcc 234481 ctaataccaa cgttgtaatc acttcgaacc aaatgatcgt cttgatgccg agactgccca 234541 tttttttcat gcttccgctt cctgcggctc caatgacaat ggtagaaaat acaatcggca 234601 caacaatcat tttaatcagg cggataaatc catctccgac aggcctcagt gccatcccga 234661 aatcaggaaa aaagtggccg atcaccgcgc cgacagccaa agcgattaaa atttgaaacg 234721 cgattaattt tttcaaatga atcccccttt agaacgatag aatgtaggca tattcatatc 234781 attcgtgatt caaatgcaaa cacctttttt caagttattt tattttgaca gcgctttcat 234841 tatgttggcg aaaaagtccc ccgcagcagg ggggactttt ttacttcatt tgaatgtgct 234901 ttagatcttc ttcagaggta tttgtgaaaa taaccggtgt tatggctgaa gcggcatgct 234961 gcttgatgta attgagatca aaggtgagaa gcagttcgcc ttgtttgacg gcttgtccgc 235021 ttgtgacatg tgcttcaaag ccttccccat tcagtttgac ggtatcgatg ccgacatgaa 235081 tcaggatttc agtgccgccg gcgctcataa agccgatggc gtgttttgtc ggaaaaatcg 235141 agacgatctc gccgtccgca ggtgcaacga cttttccttc tgatggtata atcgcaaatc 235201 cctcgcccat cattttttct gaaaagacct gatcaggcac atcccctaaa gagactgttt 235261 ctcctttaat cggataaata aaggtctcat cggaatcggg cttcagcggt ttgtcagtta 235321 ccgtgtccag cgcggcggcg gtggcaggga cgcctccggc catgattgtt ttgatgtcgt 235381 cttttaaggc atcggacttg gttccgaata ttgcctggaa gttgttgttg acctccagca 235441 cacctactgc accaagccgt tttaattcat ccttgcagac ttggcttggc tgatgaacgg 235501 tcacacgaag ccttgtgata catgcatcca ggttagcgat attttgctgt ccgcccaagg 235561 cctgcagcac gtgaaaggca agctggtctt ttgcaactgg agctttctcc tcattctgac 235621 cgtcttcatc tgtctcacgg ccgggcgttt tcaaattcca tttcagaatc gcaaatcgga 235681 acaaataata ataaatgaaa gcaaacacga tcccgacagg aatgacaacc cagccgtttg 235741 tagacagtcc gtagttcaag acgtagtcaa ttcctccgcc tgagaacgta tagccgtggc 235801 ggacatggaa taaatcacaa acgacaaaga tgacgccggc aagaatagag ttaatcaaat 235861 agagcacggg cgcaacgaac aagaaagaaa actcaaccgg ttctgtaatt ccggtcagca 235921 tagatgtgag cgccgcagaa atcatcacgc cggagatcat ttttttcttt tccggacgcg 235981 cggtatggat aatggcaaga gcaacggccg gcagacagaa aatcatgtaa gggaaatccc 236041 ccatcataaa gcgcccggct gtcgggtctc ccgcgaaaaa ccttgtcagg tcgccggtta 236101 cggtgttgcc tgttgatggg tctgtgtatt ctcccatcat aaaatagaaa ggcgtataaa 236161 aaatatgatg caggccaaaa ggaatcagca aacgatagat cgttgcataa aagaacaggc 236221 cgactgttga atcggcaatt aaactgctgg ctgcgttaat tccgttttgg atcagcggcc 236281 aaacgaatga gaaaatgacg ccgatcacca atgaactgac ggaagtaatg atcgggacaa 236341 agcgttttcc agagaaaaat ccaaggaccg gatgcagctc gattgatgaa aatcgcttat 236401 ataaataggc ggcgagaagc ccgataatga ttcctccgaa aacccccata tcaatcaggt 236461 gctcggctcc ttcatacgga ggctgaaggc cgagtaattt tcccatattg tcgagggtga 236521 cggttaaaat taagtatccg atgacagcgg caagtccggc tacaccttct ccgccggcta 236581 atccgatcgc gacccccacg gcgaaaatca gcggaaggtt atcgaataca acgccgcccg 236641 catcctttat aatagggatg ttcagtaaat ccttgtctcc gaaacggagc aaaagacctg 236701 ctgccggcag gacggcaacc ggagtcatca acgcgcggcc aagctgctgc agaatttgaa 236761 atgccttttt aaacatgaca gtctcctttt attgtgttat gagaatgatg cactctttaa 236821 tttttgagct gctttataat cggcgataac ggttacatga ttgtgttttt gaagaatgga 236881 ggctggtaca tctgtcgtga caggaccttc agccatcttt tgaatggcgt ctgctttttc 236941 ctcgccgctt gctaaaagca caatatgttt gctgaattcc atgatggttt taatgcccat 237001 tgaaatcgcg agtctcggaa ccagcaccgg atcgccgccg aagaatctgg catttgcctg 237061 tatcgtgctt tccgagagct tcacaacacg tgtccggtct tcaaaatcag atcccggttc 237121 attaaaaccg atatggccat tggcgccgat gccgagaatt tggacatcaa tgcctcccgc 237181 ctggcggatg agatcctcgt atactttgca tgccgcctca agctgcggat tgtctccttg 237241 cgggatatga atatgatcag gctgcatatt gatatgctga aaaagatgct catgcataaa 237301 atggttataa ctttgcggat gagatggaga gagaccagca tattcatcca aattaaatgt 237361 agtaaccttt gaaaaatcaa tttcgcctgc ctgatagtct gaaatcaact gcttatacaa 237421 gccgaccggt gtgcttcctg ttgccaggcc gagaacggca tctttcttag cttgtatttg 237481 ttctttaata atggcagcgc ttaacttaca gagttcttcg tagtgctcgg cgatcagaat 237541 cttcatgtga caccccctca aagagataga caagcaccat atttgttatg accaatttat 237601 gatacttgtc attacgaatt tagcaccgcc cttatcaaac tgtcaatatt aatttctgaa 237661 aatttgttat aaaagaagga tacaaatctt tcatattggg agggcaaatg gtattatggt 237721 ctcaatgaaa aagaacggat tgcatacaga atggggagaa tgaaatgaca gctttatatt 237781 ctgttatcaa gtttaaaatc attgagttaa ttaaatcggg caaatatcag gcgaatgatc 237841 agctgccgac ggagagtgag ttttgcgaac aatatgatgt cagcagaaca actgtgagac 237901 tggctctgca gcagctagag cttgagggat atattaaaag aattcaagga aaagggacat 237961 ttgtatcggc ggccaaaata caaacgccga ttccgcataa gattacgagc tttgcagaac 238021 aaatgagagg acttcgttct gaatcaaaag tgcttgagct tgtggtgatt cctgccgatc 238081 attccatcgc cgagcttttg aaaatgaaag agaatgaacc tgtcaacaag cttgtcagag 238141 tcagatacgc cgagggggaa cctttgcagt atcatacctc atatattccc tggaaggcgg 238201 caccggggct ggcgcaggag gaatgcaccg gctcgctgtt tgaattgtta aggacaaaat 238261 acaatattga aatcagcagg ggcacggaat cgatcgaacc gattttaacg gatgaaacga 238321 tcagcggaca cttattaacc aatgtcggag cgcctgcgtt tttatcagaa tcccttacct 238381 atgataaaaa tgaagaagtg gtggaatatg cgcaaattat tacacgggga gaccgaacga 238441 aattcaccgt agaacagtca tatcattcat aaagcaatgt gttttaagaa gggaatggtg 238501 gttctatgtt tttatttacg aatggaaaag tgctgtgggg agcagtgatt gctgcattca 238561 tcctttcaat tgtattttac ccttttctgc cgacgcagat gccgattcat tatgatgttg 238621 cgaacagtcc ggatctgacg gttaacaagc tggcggggac tgtgatgctg cctgttttga 238681 tggtggtgtt tgcatgggcg cggaagatca attggcaatt tgtattcgca gtgtatattt 238741 tgctgatttg ccacattgtc gtcctttgtt tagcgctcta aatcaaacag ccagaataaa 238801 actggctgtt ttctttaatt tcagcttcat ctgacaatga atgtggtgta taatagctga 238861 tgatcctaaa gaatattctg aaatttatag gtgtgaagcg gcgtattatt aaaggaaagg 238921 ctgtatactt tttgcagctt taaaaagact gaatatttaa acaattatgt gaaaggtgtg 238981 ctgattagat tgaataagct tattgaacga gaaaaaactg tatattataa ggaaaagccc 239041 gacccgtctt ccttggggtt tggacaatat tttacagatt atatgtttgt gatggactac 239101 gaagagggga ttggatggca tcatccgaga attgcgccgt acgcaccgct tacgcttgat 239161 ccgtcttcat ctgtttttca ttacggccag gctgtttttg aaggattaaa agcatacaga 239221 acagacgacg gcagggtgct gctgttccgt ccggatcaaa atatcaaacg gctgaacaga 239281 tcgtgtgagc gcatgagcat gcccccttta gacgaagagc tggtgcttga ggcattgacg 239341 caattagttg agctggagaa agattgggtt ccaaaggaaa aaggaacgtc actgtatatt 239401 cgtccttttg tcattgccac agaaccgagt ctcggtgtga aggcatccag gagctataca 239461 tttatgatcg tgctttcgcc tgtcggctcc tattatggcg acgatcagct gaagccggtt 239521 agaatctatg tcgaagatga gtatgtgagg gcggtcaacg gaggagtcgg gtttgcaaaa 239581 acggctggaa actatgccgc cagtcttcag gcacagcgga aagcgaatga actgggctat 239641 gaccaggtac tgtggctgga cgccatcgaa aagaaatatg tggaagaagt agggagcatg 239701 aacatctttt tcgtcataaa cggggaagct gtcacacctg ctttaagcgg aagcatttta 239761 agcggggtta cacgtgcgtc tgcgattgaa ttgattcgaa gctggggcat tccggttcgt 239821 gaagagagaa tatcgattga tgaggtgtat gcggcctctg cacgcggaga attgacagag 239881 gtctttggca caggcacggc agcagtcgtt acgcctgtcg gtgaactcaa catccatgga 239941 aaaacggtga ttgtaggcga cgggcaaatc ggggacctct cgaaaaagct gtatgaaacg 240001 ataacagata ttcagcttgg caaggtaaaa ggcccgttta actggacagt ggaagtgtga 240061 aaatcgaaaa agaacctgcc cggaggcagg ttctttttat tttgaatgag tcatatcagc 240121 agccggctgg cttttgcggt tttttacata atatattgca tagcaaatgg ccataaatgg 240181 aacgccgcaa tagagtgcga ttctttgatt cggatcaaag gcaatgccaa cgacggaagc 240241 caggcataac aggaacgcag caatcggcac gaacggatac aaaggggttc tgtatttcaa 240301 atcagtaacc ttgtttcccg cttcgatata acgttttctg aacatgaatt gagaagcagc 240361 gattcccatc cacacgacaa cgacggcaaa accggaaatc gacacgagca caacgtatac 240421 agtgtctggc gcaaatacgc tggacagcaa cgacagaatg ccgccgatca tgctgaacac 240481 cagcgcgtta aaaggggttc cttttgacgt cagctttgca aatgtcggat gaagcgtttt 240541 ttcttttgat aaagaccaca gcatccggga agaagcgtag agtccggaat tagccgctga 240601 caggatcgct gtcaggataa caaagttcat gatatcggct gcgtatggta caccgactct 240661 gtcaaagaca gcgacaaacg ggcttttgat gacacctgca tcttgaatcg gaatcagccc 240721 tgacagcaca aaaattgttc cgacaaagaa gagcgagaga cgccagaccg ttgtttttat 240781 cgcttttggt atcgtcttgt caggatcaac gctttcaccg gctgcgattc cgattagttc 240841 cgttcccgaa aaggcaaaat tgacggacag catcgtcatc aaaatcggga caaatccatt 240901 gggaaaaagc ccgccttccg ccgtgaagtt ggacagcatc ggagcggctt ctccgccttt 240961 gatcgggatg atgccgaaca tggcagagcc gcctaaaaga ataaataata caatggctaa 241021 tactttgatg ctggaaaacc aaaattctga ttcagcgaaa aacttgaccg aaaatgcgtt 241081 aagcaagaag atgaacagcg caaagacggc actccacatc caaaccgatg tatgggggaa 241141 ccagcgctgc attaacaggc cggctgctgt gaattctgat cccaatgcca cggtccatgt 241201 cagccaatac agccaagcga ccgtaaatcc ggtgcccggc cctatgtatt tggctgcata 241261 ggtgtgaaag gcgccggtca caggcatggc gactgacagc tcaccgaggc atagcatgac 241321 cagatagacg atgccggccc cgactaagta ggcgagtatc gttccggccg ggcctgcttg 241381 ctgaatggta taacctgagc ttaaaaacag cccggttccg atgacacctc ccaaggaaag 241441 cataaagagg tgccggcttt tcatacttct ctgaaaggtt gtctcattct tgttgtgggc 241501 agagttcatc tttttccaac tttctatcag cgatttattt ccttcctaat aaaaaatctc 241561 atgtcagaaa gtgacacgag actccggcga accggcttta agttagaata tacaaactat 241621 tccgataagt caagttgttt ttaaagagcg ggcccaagcc gcaatttctt gaatattttc 241681 gggttttgtc cggcagcagc cgccaatcag cctcgctcct ttttcatgcc aggtgcgggc 241741 gctcgccccg taagattctg cgcatgctgc gccgttccac gtttttgttt ccggatcata 241801 ttgctcacct gaattcgggt agacaatgat cggttttgac gtgttctttt ttaactcctc 241861 tatcaaggaa gggatatgct gaagcggcgt gcagttgatg ccgagtgctg caatttggcg 241921 gtgttcatca agccacgatg cgcagtcagc tgcaggtgtt ccgtcactga tatgcaagcc 241981 gtctttagca ctgaagctga tccatgcata cgtttcagga aattccttca acagccgaac 242041 aatcgctttg gcttcagtca gacacggaat cgtttcgcat gccaatacat cagctccggc 242101 ttcaatcagc gccttcatcc gggggcgatg aaattcaatc agttcatctt ctgatattgc 242161 gtagttgccg cgatactcag acccgtctgc aagataagcg ccataagggc ctatagaagc 242221 cgcaatgatc ggttttggcc gattcaaacg gttctcttca agcgaccaaa attcatcacg 242281 tgcttcagct gcgatgctga cggacaactc gatgagccgg cgtgcttccg cttcgctcag 242341 cccgcgtgcg gcaaagcctt caaatgtaga ctgatagctg gcggtgattg cacaatcggc 242401 gcctgccgca aaataatcag tatgaacttg tttaatcagc tccggctctt ccatcaggat 242461 ttttgccgac cacagactgt cattcaaatt acagcccttg cgttcaagct cggtcgccat 242521 ggcgccgtct agcacaataa gcgggtatgt atctaatatg tgttggatag gattcataga 242581 atgtaccgat gccttctttc agattttttt gaaaaagata tgaaaatcgt aatggaggct 242641 tacgtgtttg tcaataaacg caaaaagaga aaggtgttca gcccatatgt ctgaacaccc 242701 ttttcttatg atatttgttt gttgtgcgtg tcagtctttg tgtctgaaac cggccagcac 242761 tcaatgccat tatggttttt gagcacatct ttataaaaga ccggatcctt gcctgctttt 242821 ttctggcgtg tatagtcttt cagcgccgta aaaacgacct ttgatagtaa gaaaatcgcg 242881 attaaattca cgatgaccat caaacccatg aacaaatcag caagatccca gacgagctgg 242941 actttggcaa cacagccaaa cacgatcatt gccagcacgc cgatacggta gacaaaaatc 243001 agttttttgc ttttgttcaa aaagccgata ttggtttcgc cataataata gtttccaatt 243061 agagcacaga atccgaataa caaaatcaga atcgcgagaa agcctgatgc ccatgatccg 243121 acatgggagc tgagggaggc ttgtgtcaag gcgattccgc tcagacccgg agtatgatag 243181 gcatccgaaa acagaatgat aaaagcggtg cttgtacaaa tgaccagtgt atctgtcagt 243241 acaccaaaag cttggatcag cccctgtttg acgggatggc ttgttgtggc ggtggcagcg 243301 gcatttggtg cgcttcccat tcccgcttcg tttgaaaaga ttccccgtct gacgccttgc 243361 atgagtgccg cgcccaaagc cccgccggcg gcctggtcaa aaccaaacgc atttttcacg 243421 attagcgcaa gcacacctgg cagctgcgta atgttggaga aaatgacgaa aaacgcaact 243481 ccgatataca ggacagccaa tacgacgaca atggattcag ccagctttgc aatgcgcttg 243541 actccgccaa aaataatcgt gccgaataca gcaattaaaa tgagtcccaa tgtcaggcgg 243601 tttgtgccaa acgcgttttc aaaggcaagg ctgactgtat tggattgaac cgagttgaag 243661 acgataccga acgataaggt gattaacaca gcgaacagcg cgcccatcca ccttttgttc 243721 agcccttttt ccatgtaata cgccggcccg ccgcggaagc cgtttacatc ttttacttta 243781 taaatctgag ccagtgtgct ttccacaaag ctggatgctg atccgataat ggcgataatc 243841 cacatccaga agattgcacc gggcccgccg agtgcaatgg cgatagcaat gcccgtaata 243901 tttcccgttc cgacacgggc cgccatgctg atgcaaaagg cttgaaacgg agaaatgctg 243961 ttttttgacc gggaagcagc accttctctt aataccctga ccatttcttt cagcatgcga 244021 acctgtaaaa acttaagcct gaacgtaaaa tagattccaa aagaaaggag caaaacaatt 244081 aatagctttg accacaaaag atcatttgca ataccgacga tatgttctag gatttgctgc 244141 atagaatcac ctcttttttc atgtttaaaa aatgctgagc tcccattcct gcgccatatg 244201 cttcagcagc ataccgccag tgaggctgtt gccgtattca tcaatggcag gcccgtaaat 244261 gccgatgccg catccggatt gaaaaggctg ttctcttctg gcgcttggag gcaccagcgc 244321 catgatgccg ccggagacgc cgcttttggc cggcacgccg acaaacgccg catatttgcc 244381 tgaagcgttg tacatgccgc acgtcagcat taatgccttg gccaattttg ccacatcttt 244441 tggaatcacc tgctcgtgtc gaatcggatg atacccgtca tgagcaagga tcaggccgat 244501 caacgcaata tcttctgtag tgctctccat agcgcattgc ttcaagtaca cctcaagtgt 244561 ttcttctact tcagcttcta aaaagtttgt ttcttttaaa tagtaggcca gcgctctgtt 244621 gcggtgggcg gtttcccatt cagaacggaa tacttcttca tgaattcttg gccgttttcc 244681 tatcaaagtt tccatcaccg agtaaagaaa ctcgagcttt tcgtatgcag attctccggg 244741 aaggatcgaa gcgatggtga gggcacccgc gttgatcatg ggattgaagg gctttcccgg 244801 cttgttgatt tcgagccgaa tgattgaatt aaaggcgtca cctgtcggct cgacatctac 244861 gcggtcaagc acatagggaa tgccgcggct catgcaggcg gcaataaagc taatcacttt 244921 tgaaatgctt tgcatggtaa aagagacgtt ccagtcgccg gcgtgtatca tcgttccatc 244981 aggctccaat acacagatgc cgagctgtga atcattgact tttcctaaag cggggatata 245041 gtttgcgctt tgtccattgg cggcaaaagg gcgatagtat tcaacccaat catgaagctg 245101 taacgccggg tttatgtctt tctggtgctc ttttatcaat tctttcatcg aattcctcct 245161 cactgatttt tttcttaaag gactgaggtg tatcaaaacg aaggctaagg gggcgttaaa 245221 cgctttcata atagcggaag gtataattac tgtataatgg agactacaga atcatacaaa 245281 atacgacaaa aacattttga aaataagcag taagatttat aaaaacctca tgttctgggt 245341 caaaagcaat ttgcaggttt tctcccgatt ccccaaaata aaaagcgagg atgtgatcaa 245401 cataaaactg gaacggttta ttgaaaaaga cggatatata ctggccctca tgctgattac 245461 ggtgccgctg gccggtgaac tgaaatttta tcccctcaat gaagaattcc gggtcagctt 245521 tggggcaccg gtttttttct tctttttatc attgttgcgg catgtgcccg ctgtgctgcc 245581 gggttttctg actggagcgg ctgttttcat ctttcgcgtc tttctggaat tatggggcgg 245641 aggacacaat gggctgactc cgattctgta tgatcaagcg tctggctttt tcttttatat 245701 gacttacgcc tgtctgtttt ccatattaaa ggccaatcgt ttccgtgaac ggccgattat 245761 gctcggtttc attgggttta tgattgaagt tgtgtcagat tgtgtcgagc taactgtgca 245821 atttctcatt tttcatacgg ttgtcacgcc tgagaaaatc actgacattg cggtgattgc 245881 gatttctcac acatttattg tgatgagctt ttatagtgtg ctgaagctgt atgaaacaca 245941 atcgagagaa aaacagacaa ggcagcagca cgagcacatg ctgatgatcg tttccaattt 246001 atatgaagaa acggtgcacc taaaaaagac attgaaaacg acagagaaag tgacaaacga 246061 ttcgtatcag ctctatcggg aaatgaaggg caaggatgtt cagctgagcg gcagaatcct 246121 gagactggcc ggagagattc atgaagtgaa aaaggacaac cagcggatat tcgcagggct 246181 ttcaaaactg atttcgaatg agagtttgag agattatatg agggcttctg atttgctgca 246241 gctcgtgatt cgaatgaatg aaaagtacgc tgaagcacta gggaagcaga ttgattttta 246301 ctgctcgatc gagggagagc atgacgaata tcacgtattt atcgtgcttt cgatcattaa 246361 taatctaaca gcaaatgcgg tagaggctat ggatgaagag ggaatggtca gcctgaggct 246421 ccgtaagcca aatgagagta tggtagaatt ccaggtggaa gacaatggcc ccgggatttc 246481 cgagaaaatc ggagacattg tgtttgaccc gggctttact tcaaaatatg acgaatttgg 246541 cacgccttct acgggtatcg gactttccta cgtaaaggaa atcgtgacag agctagaagg 246601 ggatatcacg tttgataatc agcagcgggg agtggtgttt gccatcaggc tgcctgtccg 246661 gcatttgatt cagaaagggt gaaccaaaag ctatgcgttt ttttattgca gatgatgacc 246721 gtgcggtgcg gtcaatttta aggcagatca ttgaggacga agatctcggg gaagctgctg 246781 gtgaagcaga cgacggaagc caagtggaag ggcatatgct gcaatttaag cagattgata 246841 ttttattaat cgatctgtta atgcccggaa gagacggcat tgagacgatt cgtcagatcc 246901 agaatacgta ctccggcaaa atcgtaatga tctctcaagt ggaggcgaag gaaatggtcg 246961 gggaagcgta ctcgctcggc atcgaatatt ttatccataa gccgattaac cgcattgaaa 247021 ttgtcacggt tctccaaaag gtgaaggagc ggatcgagct tgaacactcg attggagcca 247081 ttcagcattc tctaagccgg cttgtcaatc ggactgaacg gaaagcgcgt ccccagcaga 247141 agagtgacag cggtttaaaa gaggcaggaa cattcctgtt gtccgagctg ggcatgatgg 247201 gagaaggcgg cgcacatgat ctcatggcgg tcctgcagta tttagcagaa cacgagcaat 247261 ccgagccgca cgaaaaacaa agcccttcgc taaaacaaat attcacccaa gtagcggtac 247321 ggaagctggg gacaggagcc tcacagacgg aagtcaatcg cgaaatgaaa gcctcggagc 247381 agcgtatccg cagagcgatt attcattcgc tgcaccattt tgcttcactg ggcacaactg 247441 atttttcgaa tccaaaattt gaaacctatg catcgaaatt ctttgatttt ccggttgtca 247501 gccagaaaat gaaagaactc caatccaagg atgcaaaacc ccttgcacct gctagaataa 247561 atatgaaaaa attcatccac gtgttttttt tggaagcaaa gcttttgcat gagacgatga 247621 aacaaagaag gatataaacc aaacagccgg ctgaccaggc tgtttttttg ctgcgcagaa 247681 tcccggccgg acagtgattt accgcttttt tataaaatat cagaaaataa agatattgac 247741 ttattgttta tttgtcttac aattaaacaa aaggatatat gggaaggagc ggatgtgaaa 247801 gaaaaattaa taaaagcgct tacagataga ggccgtatac acaaataaca ggaggttatg 247861 ttgatgagcc gtatcagaaa agcacccgct ggaattttag gttttccggt tgctcctttt 247921 aacacacaag gaaaactgga ggaagaagct ctttttcaaa acattgagtt tttgctgaat 247981 gagggcttgg aagcgatatt tatcgcttgc gggtctggtg aattccaatc tctcagccag 248041 aaggaatatg agcaaatggt ggaagtcgca gtctcggcag ccggaggaaa ggtgccggtc 248101 tacacggggg tgggcggcaa cctcagcaca gcgcttgatt gggcgcagct gtcggagaaa 248161 aaaggcgccg acggctactt gattctgcct ccgtatttgg tgcatggcga acaggagggg 248221 ctgtaccagt atgcgaaaac gattattgaa agcactgact tgaacgcgat tctttatcag 248281 cgcgataacg cagttctctc tgttgaacag atcaaacgtc tgaccgaatg tgaacagctt 248341 gtcggtgtca aagacggggt aggaaatatg gatttgaata tcaatctcgt ctatacgatc 248401 ggcgaccgct tgggatggct caacggaatg ccgatggctg aagtgacgat gccggcttat 248461 ctgccgatcg ggttccactc ttactcttca gcgatttcaa attatatccc gcatatttcg 248521 cgaatgttct atgatgcatt gaaaaacgga aatgacgagc ttgtgaagga actctatcgg 248581 catgtgattc tgccgatcaa cgacattcgc aaacaacgaa aaggctacgc cgtatccttg 248641 attaaagccg gtatggaaat catgggtttg aatgtaagga atacagccag accgcctgtc 248701 ggcccggttg aaaaagatca ttatcagcaa ttggaagcaa ttttgaagca ggcggctgac 248761 cgttttccga aaaaagccgc gacggtttga ccagaaaaaa cacgaaaggg gcaatgggca 248821 tgtctgtgat cacggaacaa aacacgtacc tcaactttat taacggagag tgggttaagt 248881 ctcaatcagg cgatatggtc aaagtcgaaa accctgccga tgtgaatgat attgtcggat 248941 atgtacagaa ttcaacggct gaagatgtgg aacgtgccgt caccgccgcc aatgaagcca 249001 aaacggcttg gagaaagctg acgggtgccg agcgcggcca atacttatac aaaacagcgg 249061 atatcatgga gcagcgcttg gaggaaatcg ccgcctgtgc aacgcgtgaa atgggtaaaa 249121 cattgccgga agcgaaggga gaaacagccc gggggattgc cattctgcgc tattacgccg 249181 gagagggcat gcgaaaaacg ggtgacgtca ttccgtctac tgacaaagac gcgctcatgt 249241 ttaccacccg tgttccgctc ggtgtggtcg gtgtgatttc tccgtggaac ttcccagtgg 249301 cgattccgat ttggaaaatg gcgccggcat tggtatacgg caataccgtt gtcatcaaac 249361 cggcgacaga aacagctgtg acatgcgcga agatcattgc ctgctttgag gaagcggggc 249421 tcccggcagg ggtcatcaat ttggtgacag gcccgggttc tgttgtcggg caggggcttg 249481 ctgagcatga cggtgtaaac gccgttacgt ttaccggttc aaatcaagtc ggaaaaatca 249541 tcgggcaagc cgctttagcg aggggagcca aatatcagct tgagatgggc ggcaaaaacc 249601 ctgtcatcgt agctgatgac gctgaccttg aagctgcggc agaagctgtc ataacggggg 249661 ccttccgttc aaccggccag aaatgcaccg cgacaagccg tgtcatcgta caaagcggaa 249721 tttacgagcg ctttaaagaa aaactgctcc agcgcacaaa agatattaca atcggagaca 249781 gcttaaaaga ggatgtctgg atgggaccga tagccagcaa gaatcagctt gataactgcc 249841 tgtcatacat tgagaaaggc aaacaggagg gcgcttccct tttaatagga ggagaaaagc 249901 tggagaacgg aaagtatcaa aacggctatt atgttcagcc tgccatcttt gacaatgtga 249961 catctgagat gacaattgcc caggaggaaa ttttcggtcc ggtgatcgcc ttgatcaagg 250021 tggactcgat agaggaggcg ctgaacatcg ccaatgatgt gaagttcggt ttaagtgcat 250081 ccatcttcac ggaaaacatc ggccgaatgc tttctttcat tgatgaaatc gatgccgggc 250141 tggttcggat caatgcagaa agcgcaggtg ttgagctgca ggcgcctttt ggcggcatga 250201 agcagtcgag ctcccactcc cgagaacagg gtgaggcagc gaaggacttt ttcacagcga 250261 tcaaaactgt ttttgtgaag ccgtaatggt gctggaaaga ggcgtgcgtc tctttcccgg 250321 tttatcacaa ccagcatatg attctctact ttgaaaagga gaagatacta tgaaaaaaga 250381 ctttgcgagt gttactccgg cgggcaaaaa aacgtccgtg cgctggttca tcgtgtttat 250441 gctgtttctt gtgacctcta ttaactacgc ggatcgagcg acgctttcca tcaccggaga 250501 ttccgtccag cacgatttgg gattggactc ggtcgccatg ggatatgtct tttctgcctt 250561 tggctgggcc tatgtcatcg gacagcttcc gggcggctgg ctgctggacc gttttggttc 250621 aaagactatc attgcgttaa gcatcttttt ctggtcgttt tttacgttgc tgcaaggggc 250681 gattggcttt ttctccgccg gcacagcgat tatcctgctg tttgcactgc gttttctggt 250741 tggtttatca gaagcgcctt catttcccgg aaacggcaga gttgttgcct catggtttcc 250801 aagctccgag cgcgggacag cttcagcctt ttttaattca gcacaatact tcgcaatcgt 250861 cattttttct cctttaatgg gctggcttac ccactctttc ggctggcatt ccgttttcgt 250921 tgtcatgggt attgcaggca ttcttctggc tgtcatctgg ctaaaaacgg tgtatgaacc 250981 gaaaaaacat ccgaaggtta atgaagctga gcttgcgtac atcgaacagg gcggcgggct 251041 gatttccatg gatgacagta aaagcaaaca agaaacagaa tcgaaatggc cgtatatcaa 251101 acagctgtta acgaaccgca tgctgattgg cgtgtacatc gcgcaatact gtattacgac 251161 tctcacctat ttctttctca catggtttcc ggtatatttg gttcaggccc gcggcatgtc 251221 tattcttgaa gctgggtttg tcgcttccct gccggcgctg tgcggatttg ccggcggcgt 251281 gcttgggggc attgtgtcag acatcttact caaaaaaggc cgttcactga cctttgcaag 251341 aaaagtgcca atcattgccg gcatgctgct gtcttgcagt atgattgtct gtaactacac 251401 agattcagca tggctcgtcg ttgtcattat gtcgctcgcg tttttcggaa aaggcttcgg 251461 cgcattgggt tgggctgtcg tgtcggacac gtctccgaaa gaatgtgcag gattaagcgg 251521 cggtttgttc aacactttcg ggaatattgc ctcaattaca acaccgatta ttatcggata 251581 cattgtcaat gccactggat ctttcaatgg cgcgcttgtg tttgtcggcg ctaacgcgat 251641 tgcggcgatc ctcagctatt tgctgctggt cgggccgatc aaacgggtcg tgttaaagaa 251701 acaagaacaa gaccccgatc aatcgttgcc tgtctaatat ttatgaaagc gctttataaa 251761 gggaggaaaa tgcatgagtt caccgataca agagcaggtt caaaaagaaa aaagatcgaa 251821 tattccctca atttctgaaa tgaaggtgat tcctgttgcg ggacatgaca gcatgctgct 251881 gaatctaagc ggagcacaca gcccgttttt tacccggaat atcgtaatct taacagacag 251941 cagcggaaat cagggagtcg gcgaggtgcc tggcggagag catattcgcc gcacactgga 252001 gctgtcagag ccgcttgttg tcggaaaatc tatcggtgcg taccaggcga tattgcaaac 252061 ggtcagaaag cagtttggcg atcaggacag gggagggcga ggaaaccaga cgtttgattt 252121 gcgcaccact gtgcacgccg tcaccgcact ggaagcggct ttgttggatt tgcttggaaa 252181 gtttcttcag gaaccggtcg cggctttgct gggcgaaggg aagcagcgtg atgaagtaaa 252241 aatgctcggt tacctctttt acatcggcga ccgaaatcgg acgaccttgc cgtatcaaag 252301 cgatgagcag tcagattgtg cgtggttccg tctgcgccat gaggaagcgc tgacgccgga 252361 ggccattgtg cgtcttgccg aatccgcaca ggagcgctat ggctttcagg atttcaaatt 252421 gaaaggcggg gtgctgcggg gagaagagga aatcgaagct gttaccgcat tatcgaaacg 252481 ttttccagag gcaaggatca ctcttgatcc gaacggggca tggtcattag aggaagctat 252541 tgcattatgc aaaggaaagc aagatgtgct cgcgtatgcg gaagatccat gcggggatga 252601 gaatggctac tccgctcgtg aagtaatggc tgaattccgc cgcgcgacag ggcttccgac 252661 tgcgacaaat atgattgcga ctgactggcg ggaaatgggt cacgcgattc agctccacgc 252721 ggtcgatata ccgctggctg atccgcattt ttggacgatg caagggtcgg tgcgggttgc 252781 gcaaatgtgc catgattggg gtttgacatg gggctcgcac tccaacaacc actttgatat 252841 ttcccttgcg atgtttaccc atgtggcagc agcggctccg gggcggatca cggcgattga 252901 tacccattgg atctggcagg acgggcagcg attaacgaaa cagccttttg agatttcttc 252961 tggctgtgtc aaggtgccgg ataagcctgg actaggcgtc gatattgata tggaacaagt 253021 ggaaaaagcg catgagatct atcggaaaat gaatttaggc gcacggaatg atgcgatccc 253081 aatgcagttc ctgatcagca actgggaatt tgaccggaag cgcccgtgtc ttgtgcgata 253141 agtttgattg taaatattgt catatccgct attttgtctt acaattgaac aactgaaggg 253201 agagttgttc gtgtacgaag gtttagagga tttgaaagtc gatacagtca atcggaaaac 253261 attagccaag caggtcatcg aacggattgt ccatttatta tcgagcggac agttgagggc 253321 cggagacaaa ttgccgacag aaatggaact gatggacatt ttgcatgtca gcaggccggt 253381 gctacgggaa gcactcagtt cacttgaaac gctgggcgtc attacgagaa aaacacgagg 253441 gggcacatat ttcaacgata aaatcggcat gcagccattt tccgtcatgc ttgctttggc 253501 cactgataat cttccggcta tcattgaagc gcggatggcg ctagaactcg ggctcgtgac 253561 aattgccgcg gaaaaaatca atgaggaaga gcttcagcgt ttgcagaaga cgatcgacga 253621 tattgccaac agcactgaca atcattatgg tgaagcggat aaagagttcc atcgaattat 253681 tgcgttaagc gccaataacc ccgtcgttga agggatgatt cagtccctgc tgatcaccca 253741 tgcgaaaatt gacagccaaa ttccgtacag ggagagagat gtaacggtcg aatatcacaa 253801 aaaaatctac gacgcccttg ccaaaagaga tccgtacaaa gcacattacc acatgtatga 253861 gcatctgaaa tttgtccgtg acaaaattct aaaaggaatg gatgaaaaat aatggtgagc 253921 aaccgcagtt gaaacgtaag agctgcggtt tttttaaacc aatttagaaa acgcttacta 253981 aaatatgagg agtgattttc atatggcgat gaacctcagg aagaaccaag ccccccttta 254041 catcaaagtg catgaaatag ataacaccgc gattattgta aatgatggag ggctgccaaa 254101 gggcactgtt ttctcatgcg ggctcgtact tgaagaggat gttcctcaag gccataaggt 254161 ggccctcacc gatctcaatc aaggggacga gatcgtgcgt tacggagagg tgatcggatt 254221 tgctgatgag acgatcaaac gcgggagctg gatacgggaa gccctcgtga gaatgcccgc 254281 tcctccggcg ttagacgatc ttcctctcgc aaacagggtg ccgcagccgc ggcccccact 254341 tgaaggatat acatttgaag gataccgaaa tgcggatggc agtgcgggga caaaaaatat 254401 cctcggcatc acgacaagtg ttcaatgtgt tgttggcgtt ttggattatg cagtcaaacg 254461 aataaaagaa gagctgctgc cgaaataccc aaatgtcgat gacgttgtgc cgctgcatca 254521 tcaatacgga tgcggcgtgg cgatcaatgc gcccgacgct gtcattccga tccgcacgat 254581 tcaaaatctt gcgaagcatc cgaacttcgg cggtgaagta atggtaatcg gattgggatg 254641 tgaaaagctc ctcccggaaa gaattgcctc cgaaaatgat gatgacattc tatcgctcca 254701 ggatcaccga ggttttgcgg cgatgatcca atccattttg gaaatggcgg aggaacggtt 254761 aatcaggctg aacagcagaa cccgggtgtc atgccctgtt tcggatctgg ttatcggcct 254821 gcaatgcggc ggcagtgatg cgttttccgg cgtgacggcg aaccctgccg tggggtatgc 254881 ggctgattta ttggttcgcg caggtgcaac ggttttgttt tctgaagtga cagaggtgcg 254941 ggatgccatt catttattaa cgccgcgggc tgtcagtgaa gaggtcggac aatcgctgat 255001 caaagagatg aagtggtatg acagctatct tcggcgggga gacgcagacc gtagcgcaaa 255061 cccgtcacca ggcaataaaa aaggcggatt atccaatgtg gtggaaaaag cgttaggttc 255121 ggtagcgaaa tcaggcacaa gccccatctc cggcgtgctc ggccctggtg aaagagcaaa 255181 gcaaaaaggc ctgctgttcg cggcgacacc ggcaagcgat tttgtgtgcg gcaccctgca 255241 gctggctgcg ggcatgaatt tgcaggtgtt tacgacaggg agaggaacac catatggcct 255301 ggctgctgcg ccggttctga aagtatcgac gcggcattcc ttatcagagc attgggctga 255361 tttaatcgat atcaatgccg gccgaatcgc gacaggagag gccagtatcg aagacgtagg 255421 ctgggaaatc ttcaggacga ttttggatgt ggcaagcggc cgcaaacaaa cgtgggcaga 255481 ccgttggggt cttcataatg atttgtgctt gtttaatcct gctccagtga cttgattcat 255541 gtttttatag cggaaagatg gaatatgctg taaaatgaaa atcagcgtat aggaaacgga 255601 ggggttacag catggcattc attagattcc gagtgacacg aattcaatag tgaacaactc 255661 tcgcctgaat gcgagagaat cgggatgaat ccgcctatgt atgagccctt atatggttat 255721 caaaaaagag ggtggcgtgc ctgccctttt ttgtgccttc aagcatccct tctctctact 255781 gcaggccgga gcatgagaaa ggggaaatgg gatgacaaac cttaacgaaa aacagcttat 255841 cactgagatt gtcgggcttg cacgcagcca aggtttgacg gttcattctg agaacgcgca 255901 attgaatgaa accggaatgg actttcaagt tgtatttgcc aaggacgaca caggtatgcc 255961 atgggtgctg cgaaaaccgc ggcgaagtga tgttgtggaa agagcatctg cagaaggcat 256021 aacgcttgcc tttctccgcg cgaatctgac tgctgatgtg ccggattgga gaattcatac 256081 accggaattg atcgcttacc ccatgttaaa aggaacgccg gctgctggaa ttgacttgga 256141 acaaaagcaa tatgtatgga atatggatca tcagccgccg tcagacgact ttgtccgcac 256201 acttgccgac atactggctg aattacatgg cacggatcaa atatctgctg ggcaatccgg 256261 aatagaagtg ataaggccag aagatttcag gcaaatgaca gcagactcta tggttgatgt 256321 gaagaataag cttggcgtat ctacgacgct ttgggaaaga tggcaaaagt gggtagatga 256381 tgatgcatac tggccgggtt tctcttcttt gatacacggc gatctccacc cgccgcatat 256441 ccttatcgat caaaatggac gtgtcacagg acttctggat tggacagaag cgaaggttgc 256501 tgacccagcc aaggattttg ttctttatca aaccattttc ggagaaaaag aaactgcccg 256561 tttgcttgaa tactatgatc aagcaggcgg ccgaatatgg gcaaaaatgc aggaacacat 256621 ctcagagatg caggcggcgt atccggtgga aatcgccaag ctagctctgc aaacacagca 256681 ggaggaacac atcaatatgg cgctggaagc acttggtgta acatcggatt aagaattgac 256741 ttcgtttcat gaaccgagta ttataaactc tacaaataat agaacggatt aacaatcgtg 256801 aggaagagca agtacgcatc agaatggagg ttcagagagt cggtggcagg tgtgaaccga 256861 tcctcccctg atgccgaatg ggcttctgaa ttgctttgct gaacggatag taggcgatgc 256921 cgggtttctc tccccgttac caagagagga gtatcgaaac ataggttttc tgtacttaga 256981 gtgaacggct gtatagctgt taataaaggt ggtaccgcga gaccctcgtc ctttgcatag 257041 gacgggggtt ttttgtgttt cttaaaggag gtgacggcca atgtacgatg gctggtggtg 257101 gcatagcaga tgagttagaa aggaggatat caaatggtca ttgcaactga tgatcttgag 257161 gtcgcatgtc ctaaatgtga aagagcggga gaaatcgaag gaacaccttg cccggcctgc 257221 agcggaaaag gtgttattct gactgctcaa ggatatacgc ttctcgattt tatccaaaag 257281 catttgaata agtaaaggag aaaagctgag ctgagatgag agcagaagag cagagtaaga 257341 ttcgtgaggc cgcagcaggt acgatttttt tgctgatcgg aacagtttgt tttgcgtcta 257401 aatcgatttg gataaaatgg gcataccaaa tgggtgctga gccagatgcc gtgctgctat 257461 acaggcagct gctggctgtt ccgctgtttt ggctgatttt tttaatatac cgtcctccaa 257521 tgccagacgg taagaaaaaa ggagacctat ggaaggcttg tggcgcggga gtgttttgtt 257581 tttttctgtc tcccttgctt gattttatcg ggctgaacca tgtatccgca atggttgaac 257641 gtatattgct gatgagctat ccgttgtttg tgtttggatt caccgcgtgt cgtgaccgga 257701 aaatgtcctc aattcaggac cttttcgcag ttctggcggt catgtttggg cttttcttgg 257761 cgctgggcgg ctggaatgct gagcttttcc aggcgaatat gattggagct gtattcattt 257821 tgttatcttc ggccgtctat gctggttatc ttgtcctttc cgggcatctc gtccatcaaa 257881 tcggagggat ccgtctcaat gcatacggga tgacagctgc tggagctgcc atgatgcttt 257941 acacagggat aaaatcggcg gctggcatga atacgccaat ggcagcatat ccgctttcta 258001 tgtatggttt gttcgcagta attgcagtcg ttaccacagt gattccattt gtgctaatgc 258061 ttgagggcat aaaacgaatc ggggcacagc gagccgccgc catttcaatg gcagggccta 258121 tcctgacgat tttctatgga gctttatttc tcggtgaacg gctcgggctc attcaagtca 258181 ttggatgcgg tggcgtattt tttgtcatta cgggcatgga atacaggaag ctgaaaacag 258241 gaaaaaaaga ataattttta taaaacacac acgtttttca attacaataa gtgtaattac 258301 gtgtgtgttt tttgattttg taaaggttag gtgaggagat gcagcgcata ttgcttgtag 258361 aagacgacca ctcaatcagt gaaatggtgg atcattattt aacaaaagaa ggctttggaa 258421 ttgtgcatgc tttcgacgga gaagagggca tccggctgtt tcagcagggt tcatacgatt 258481 tggtcctcct tgatatcatg ctcccgaagc tgaacggcat ggattttctg aaaatcatcc 258541 gggaaaaaag caatataccg gtcttaatga tttcggcaaa agatggagat gtggacaagg 258601 cattgggact gggctttggg gcggatgatt atatcgccaa accgttttcg atgattgagc 258661 tgacagcccg agtaaaagcc gcgatacggc gggcgacgca atattcggca gaggagccgg 258721 ctgtgaataa ggtgatccgg attcaccagc ttgcgataga tatagacaat gtttccgttt 258781 tgaaaaacgg agagccgctc cagctgacgt caacagaatg gcagctgctg tgcttatttg 258841 catcaaatcc taaaaaagtg tttacgaaag aacaaatcta ccgttccgtt tggaatgaag 258901 agtactttga tgatcagaac atcattaacg tacatatgcg gcggctcaga gaaaagattg 258961 aggatgaccc ctcctcccct caatatatta aaacgttatg gggcatcggt tataaattag 259021 gagagtttta gaatgacagt gctatgggtg gccgctgtca tcgctctggc gtgtctgaat 259081 gtgattcaat tcataatgaa aaagaagcgg gacgggaatc tggcttacac ggctgaccag 259141 cttagctaca tgctcagccg ggattcggca ggacaaattt tgcttcctac agacgatcat 259201 gcgctcaaag acttgcttgt taacatcaat cttatcgttg agaatcgtca gcagatcagc 259261 gcccaatttg ccaaaacaga gcaatccatg aagcggatgc tgaccaatat gtcgcacgac 259321 ctgaaaacgc cgttaacggt cattctcggt tatattgaag ccattcaaag tgacccgaac 259381 atgccggacg aagagcggga aagattgctg gggaagctcc gccagaaaac aaatgaactt 259441 attcagatga tcaattcctt ttttgattta gcgaaattag aatctgaaga taaagagatc 259501 ccgatcacca aagtacatat gaacgacata tgcaaacgaa atatcctgca ctattatgac 259561 gctgttcagt caaaaggctt tcaagcagcc atcgatatcc ccgatacgcc ggtgtatgcg 259621 caggcgaatg aagaggctct ggacagaatc ctgcaaaacc tattgtccaa tgcgattcaa 259681 tatggcgcgg ccggcaagtt aatcgggctg acgctgtctt atgatgagag gaacatcgcc 259741 atcaccgtat gggatcgcgg aaaagggatt agtgaaaccg atcagcagcg ggtgtttgag 259801 aggctgtaca cactggaaga atccagaaat aaagcatttc aaggaagcgg cttgggttta 259861 accatcacaa aacggcttac agaaaaaatg ggaggcatca tatccgtcca aagcaagccg 259921 tacgaacgga ctgcatttac gatcacattg aaacgcatga catattaatc gtaagaattt 259981 cttaaggttt gagaaataaa aatgacaggg ctcgccgcta caatagaaaa caggaaaaga 260041 gagggaagga gaaacaaagt tgacttatat cgtacaaaca aacgggctga ccaaaacata 260101 tcagggcaaa gaggtcgtat ccaatgtcag catgcatatt aaaaaaggtg aaatctatgg 260161 ctttctcggc ccgaacggcg cggggaaaac aaccattatg aaaatgctga cgagccttgt 260221 caaaccgaca agcggtgaaa tcatcatcct tgggaacaag ttcacccaca cgtcatatga 260281 ggtgctgggg aacatcggca gcatgattga atatccgatt ttttatgaaa acctgacagc 260341 tgaagaaaat ttagatctgc attgtgaata tatgggatac cacaataaaa aagccataca 260401 agaagtgctg gatatggtga atttaaaaca aatcgacaaa aaacccgtca aaaccttttc 260461 cctcgggatg aagcagcgcc ttggaattgc gcgtgccatc ctcacgaagc cggacctgct 260521 tattctggat gagccggtga atggtcttga ccctctcggc attaaaaaga tcaggcaatt 260581 gtttcaagtg ctgagcaaag agtacgggat gacgctgctg atctcaagcc acctgctggg 260641 tgaaatcgaa caaatcgcgg acacaatcgg cgtcattcgg gacggcaggc tgcttgaaga 260701 ggtatcaatg gaggatgtca ggggccagaa cactgaatac atcgagcttg tcacgccgaa 260761 tcagacaagg gcctgctttg tgctggagaa agagctgcaa ttaaccaact ttaaaatatt 260821 aaatgagaaa acgattcgaa tttacgaggc tgaagcctct caggctgcca tatccaaagc 260881 attgatttta aatgatgtag acattgaatc aatgaacaaa aagtatacgt cgctggagga 260941 ttattttatc aaattgatca acggcaatag catcagtgcg taaaggagga gagacacgtt 261001 gatgaatttg atcagaatcg aattaagaaa aatgaaaatg ggctggtata tcagaggtgc 261061 cctcattgcc aacgtgatca ttatgggttt tatgtggctg atcagttatt ccgaaaaagc 261121 cgatggcggg gtttcgttcc aaagtacgga tgaagcattc ctcatcatcg gcaccttcgt 261181 cagagcggta tttatcgtat ttggcgctgt gctgatcgta aaattggtga tttcggaata 261241 taaaaacaaa accattcttg tgatgttcac gtacccgatc agccgtaaaa agctgctcac 261301 cgctaagctc atgatcgcgg gcggactgac gtttatcacg attttacttt caaatatact 261361 catagccgcc ggtttctttt ggctgaactc gatctgccat ttcataccgg gagagcttac 261421 ttccgagatc atttctcaac aggcggtcaa aatggcggtt ttcgcttttg gcgccgctgg 261481 aaccagttta gttcccatct tttttgggat gcgtagacac tcggttccgg cgaccatcat 261541 ttcatctgta gtaattgtga tgctcatcag ctcaacaagt ccgggcttct cgatttcatc 261601 tgttgtgtat atcccgttat cgttagcggc attcggtttg ttcttttcct acatggcgat 261661 caggaatgcg gacaagcagg atgcgtaaac aaaggcgccc aatatgtata aaaggccgat 261721 gctgtcagca ccggcctttc cattatgagt ctgttcttgt ttcaagataa tgcttcttgc 261781 caatctcttt gctcatcata tagaaatgga agcaatattc accgattgcc atgacgatcg 261841 cgccgaataa agccgccaat gcaacttcac cgccagtcat ccccatagaa agcggcatgc 261901 ccatcagcca gatcacgaga aaggccaaac caaaatcagc caaagttgca atcatattat 261961 tccatttcgg caatacataa agatcgccca gcaaataaga aataacccct aacacaatcg 262021 tcattagcag cgtatcacca aacgtgaaac caaagcccag accaagcacc agatacaaca 262081 caataatcgt cataatacct ttaatagcga gcgctttcac atgtgtcatt acaattcctc 262141 cttttgtcat ttgatttgtt atgtataatt cctcaaatgt aaaaagttaa accttatttc 262201 ttttcggagg cgggtgcaaa tctgctgggg agaggtcaat gatgtgaatc caggaattga 262261 ggctgcggcg cttcgacagc ggaaacgtga agcttgtact gcaccggacg ctgctttgat 262321 gcccaacagc ccattatgtt tgctgttttt agatgaataa atttaaaaac ttctcctgtc 262381 cctccgtcat cacttctgaa gtaatgaaat atgatgaaaa gagatcaagg ggaggtgacg 262441 tgatggcggt cgtgagagca acgagtgcgg atgtcgattt gatggcaagg ctgctcagag 262501 cggaagcgga aggcgaaggc aagcagggga tgctgcttgt cggcaacgtt ggaattaatc 262561 ggctgcgggc gaattgctca gattttaaag gcctccgcac catcaggcag atgatttatc 262621 agccacacgc gtttgaggct gtgactcatg gatattttta tcaaagggcg cgagatagcg 262681 agcgtgccct tgcacgccgg tcgattaatg gtgaaaggcg ctggcctgca aaatttagtt 262741 tatggtactt caggccgcag ggggactgtc cagcccagtg gtataaccag ccgtttgtgg 262801 ccagatttaa gtcacactgc ttttatcagc cgacggcgga gacgtgtgaa aatgtatata 262861 acacatttta gagacaggac accgttcaaa ttgaacggtg tttttctttg aaaagatgca 262921 atgcaaaata ttcctgtgag ataatcaaag aaaaaagagc tgacggagat gacagaatgg 262981 caacaattga cctgcaaaag aaaagtgtaa agatcgtact ggagaaaaag cagttaacga 263041 aggtgacggc tcgtgttgga ctggttcttg atattacggg atcgatgaga ccgctctaca 263101 aaaacgggac ggttcaaaat gtggtggagc ggattttggc agtggctgat cagtttgatg 263161 ataacggttt gctggatgta tgggtgtatg ataatgaatt ttcccgatta aagccagttt 263221 cagaaaagga tttttcgggc tatgtcgatc gtgaaatttt aaataatgac cgcttgcata 263281 aattcggcag aaatgatgag ccgccagtca tgaaggacgt gctgcgcaaa tatgttacgg 263341 aggaaccgag ctcgtatcct gctttcattg tttttatcaa tgacgggggc tgtaaaaagt 263401 caatcaaacc gataattgaa gcttcttctg ataaaccggt gttctggcag tttgtcggca 263461 tcggaaacgg aaactttgat tttctcaata aactggatac gttagaaggg cgtgtcattg 263521 ataacacgaa cttcctgcat atcgaagaga ttgaccgcat ttctgatgat gagctttatg 263581 atgctctgct tgctgaattt ccattttggc tgaaagaagc gaaggaaaaa gggattgtaa 263641 gagaacaaga gcctcctgct gaaaagccga aaaagaaggg ctttttcagc agattgtttt 263701 cgaaataact gataaagagc actgagtcat tctgcgaaat ggctcggtgt ttttgttttt 263761 ttaagatcat gtgaagaaaa ataggccgaa tgggcggctt gcaaacgaca ggatatgcag 263821 aaaacgcgtc attcagccag ctttcggcat gtttcagcag caggcttgtg agggaagacc 263881 tgtttttaat gttcagcgct tacaatcagt tcacacttct tcacagtcgt ttaacaatga 263941 tttcctataa tggagacgat caatgaggag agaggggatc ttgaatggca tacgacagtc 264001 gttttgatga atgggtacag aaactgaaag aggaaagctt tcaaaacaat acgtttgacc 264061 gccgcaaatt tattcaagga gcggggaaga ttgcaggact ttctcttgga ttaacgattg 264121 cccagtcggt tggggccttt gaagtaaatg ctgcgcctaa cttctcaagc tatccgttta 264181 cattaggggt agcgtcaggt gatccgcttt ctgacagtgt cgtgctttgg acacgtctgg 264241 caccagatcc gctgaatggc gggggaatgc cgaagcaagc agtgcctgtc aaatgggagg 264301 tcgcaaagga tgagcatttc cgcaaaatcg taagaaaagg cactgaaatg gctaaaccaa 264361 gtcttgccca ttccgttcat gtggaagcgg acgggcttga gccaaacaaa gtgtactatt 264421 accgtttcaa aaccggccat gaactaagcc ctgtcggaaa aacaaaaaca ctgcctgccc 264481 ctggcgccaa tgtgccgcaa atgacctttg catttgcttc ctgccagcaa tatgagcacg 264541 gatattatac ggcctacaag catatggcaa aggaaaagct tgatcttgtc ttccatctcg 264601 gtgattacat atatgaatac ggcccaaatg aatatgtatc aaaaacaggc aatgtccgca 264661 cgcacaacag cgcggaaatc attacgctgc aagactatcg gaaccgtcac gctcaatacc 264721 gttctgacgc caatcttaaa gctgcacatg cggcattccc ttgggttgta acttgggatg 264781 accatgaagt tgaaaacaac tatgccaata aaatacctga aaaaggacag tcggttgaag 264841 cattcgtgct ccgccgcgcg gcagcatacc aggcatacta tgaacatatg ccgctccgca 264901 tttcctcttt gccgaatggc ccagatatgc agctgtaccg gcactttacg tacggaaacc 264961 tggcgtcctt caatgtgctt gatacccgcc agtacaggga cgaccaagcc aataacgacg 265021 gcaataagcc gccttctgat gaatcgcgca atccgaatcg gactctgctt ggaaaagaac 265081 aggagcagtg gctcttcaac aatttgggca gctcgacagc ccactggaat gtgctggcgc 265141 agcagatttt ctttgccaag tggaatttcg ggacaagcgc aagcccgatc tacagcatgg 265201 attcgtggga cggctacccg gctcagcgcg aacgggttat caatttcatt aaaagcaaaa 265261 atctgaataa tgttgtcgta ctgacaggtg atgtacacgc aagctgggca tcgaatttgc 265321 atgtcgattt cgagaagaca agttcaaaaa tattcggagc cgaatttgtt ggaacctcga 265381 tcacttccgg agggaacgga gcggataagc gagcggatac ggaccaaatt ttaaaagaaa 265441 atccgcacat ccagttcttt aacgactatc gcggatatgt ccgctgtaca gtgacgcctc 265501 accagtggaa agccgattat cgggtgatgc catttgtgac cgagccgggc gcagccattt 265561 ccacgcgggc ttcattcgtt taccagaaag accaaaccgg gttgagaaag gtatcatcca 265621 caacaatcca aggcggggtg aagcaatccg atgaggtcga agaggatcgt ttcttttcgc 265681 acaacaaagc ccacgaaaaa caaatgatta agaagcgtgc aaaaatcacg aattaaggag 265741 tggaaattat gttttcaaac attggaatac cgggcttgat tctcatcttc gtcatcgccc 265801 tcattatttt tggcccttcc aagctgccgg aaatcgggcg tgccgccgga cggacactgc 265861 tggaatttaa aagcgccaca aaatcacttg tgtctggtga tgaaaaagaa gagaaatcag 265921 ctgagctgac agcggtaaag caggacaaaa acgcgggctg aatgctgatg aggcagacac 265981 cgggtctgcc tcttttttta tgaaagggag ggcttttttg aatggataaa aaagaaaccc 266041 atctgatcgg gcatttagaa gagcttcgcc gccggattat cgtcaccctt gcggcatttt 266101 ttctatttct catcacggct tttttgttcg tacaggacat ttatgactgg ctgatcaggg 266161 atttggatgg aaagctggct gtgctaggac cgagtgaaat cctctgggtg tatatgatgc 266221 tttccggcat ttgtgccatt gcggcttcta tccctgttgc cgcgtaccag ctgtggcgtt 266281 tcgttgcacc ggcgctgact aaaacggagc gcaaggtgac gctcatgtac ataccaggtt 266341 tatttgcgtt gtttttggcg ggcatctcct tcggatactt tgtcttgttt ccgatcgtgc 266401 tcagcttttt gactcattta tcctccggcc actttgaaac gatgtttacg gctgaccgct 266461 actttaggtt tatggtgaat ttgagcctgc cgttcggctt cttgtttgag atgcccttgg 266521 tggtgatgtt tttaacaagg ctgggcatct taaatcctta cagactggcc aaagcgagaa 266581 agctttccta ttttctgctg attgtcgtgt ccatattgat tacaccgcct gattttattt 266641 ctgattttct cgtgatgatc ccgcttcttg tcctgtttga agtgagtgtc accctatcgg 266701 cgtttgtcta caaaaagagg atgagggaag aaacagcggc ggccgcttag tgcagcgtac 266761 cacccggtga cttcacatcc tcatcatatt gtgcggccgt aacagcggcg attctcaatg 266821 cccggacaat cgtgtccagg ctgaggctcg gcgctgtttt gtcgattgtt tgctgcggaa 266881 tgtaaggaat atgaataaaa ccgccgcgaa tgtgtgggga tgtccggcta atgtgatcca 266941 ttaacccgta gaacaaatag ttgcatacaa aggtccccgc tgtgtaggaa accgcagctg 267001 gaatgccgtg ttccttcatc ttagcagtca ttcgtttcac gggaagcctt gtccagtaag 267061 cggcgggccc atctggagaa atctcttcat caatcggctg atgtccttcg ttatcgggga 267121 ttcgcgcatc tgcaaggttg attgccactc gttccggtgt aatctgcatc cgtcctcctg 267181 cttggccgac acaaattacg atatctggct gatgtttttg aatggcttgg cgcagagtgt 267241 ccagagcgga tctaaagacg gttggaattt gttccgctgt aataatggct tcttctgtct 267301 cgaagccatt aagccgtttc gccgcttccc atgatggatt gacggtttct ttgtcaaaag 267361 ggtcaaagcc tgtgatcagc actttttttc tcattctccc atctcctttt tcttttattc 267421 tattgtttat ttatgggttt ttcatcaaaa taatgtaaag gagtgaatca taatggagca 267481 tttgccggag cagtatcgcc agttattccc aaccttgcag acgcatacga tgcttgccag 267541 ctgttctcag agcgcattgg cagagcctgt atcaagggcg atccaggatt attatgatag 267601 cctgctgtat aaagggacga actggaaaga agcgattgaa aaaacagagt ttgcgagaaa 267661 cgagtttgca aagctgatcg gggctgaacc ggatgaagtg gcgattgtgc cgtcagtttc 267721 tgatgcactg gtttctgtag catcgtcctt aactgcattt ggaaagaagc acgttgtata 267781 tacagatatg gattttccgg cggtgcctca tgtttggcag gcacactccg attataccgt 267841 atccgtcatt ccatcaatag acggcgtgct gccgcttgaa caatatgaaa cgcatatttc 267901 ggatgaaaca gtactgacgt gtgttcctca cgttcattat cgtgacggct atgttcagga 267961 tataaaagcg attgccgaga tttctcagag aaagggctct ttattgtttg tagatgctta 268021 tcaatcagcc gggcatattc ccattgatgt gaaggaatgg ggcgtagata tgctggcagc 268081 aggcacccgg aagtatttgc tcggcatacc gggtgtggcg tttctttatg tgagaaagga 268141 gctggctgac gcactgaagc cgaaagcatc agcttggttc ggaagagaga gcggatttga 268201 tggggcttat gcaaaagtcg cgcgccgttt tcaaacgggc accccagctt ttatcagcgt 268261 atacgcagct gcagcggctt tatcgctgct gaatcatatt ggggtttctc atatcaggga 268321 tcatgtgaaa acgatctgtg ccgatgcagt tcaatatgcc gctgaaaaag gcctgcagct 268381 ggcggcggca caaggtggga ttcagccggg catggttgcg atccgggatg agcgggcatc 268441 ggaaacggcg gggttgctga agaagaaaaa agtgatttgc gcgccgcggg aaaatgttat 268501 ccgtctcgct ccccattttt ataatacgaa ggaggaaatg cggcacgcga ttgatgaaat 268561 cgcggcgaaa acgatccaca agtaaacatg aaaaagcccc tgaacactag tcaggggctt 268621 ttcatattaa tgatctactt taacgcgttt cataaagaaa gcgccaatta aaccgataat 268681 ggcaacaatc attgcaaaca caaatgcgtg ctgtacgcct gctgtcaaag cttgcgggat 268741 gactgccgga tcggcagggt ttttaactgt actcatataa tcatgctggc ctgcagccat 268801 aatgctgacc gcaaccgctg ttccgatagc gccggccatt tgctgcagcg tgttcataat 268861 ggcggtgccg tctggataaa attcacgcgg cagttggttt aaaccgtttg tctgtgcagg 268921 catcatgatc atagaaatcc cgatcatcaa gcaggtgtgc aggatgataa tcagcacagc 268981 tgttgaagtg gtcgtgacat ttgagaagaa ccatagtaca acggtgacaa tcacaaatcc 269041 cggaatgaca agccatttcg gcccgtattt atcgaacaag cggcctgtaa caggggacat 269101 aaatccattt aaaataccgc ccggcaagag aacaagacca gatgcaaatg cagtgaggac 269161 taagccgcct tgcagataca tcggcagaag cagcatagat gacagaatga ccatcataca 269221 aatgaacacc atgatcacac ccaaaataaa catcgggtat ttgaacgcac ggaggttcat 269281 cataggctgc ttcattgtca gctggcggat tgaaaataag ataaggccga caacgccgac 269341 aatcagcgac acgataacag tcgggctgga ccatcccccg gagccttcac ccgcgttgct 269401 gaatccgaat acaatgccgc cgaagccaat cgtcgacagg atgatagaca atacatcgat 269461 tttcggcttt gtcgtttcag atacattttg catatatgcg ataccgaaaa caagcgccag 269521 cacaaggaat ggaagagaga tccagaaaat ccagtgccag ttgagatgct ccagaaccaa 269581 tcctgagaaa gttgggccga tggcgggcgc gaacataatg acaagcccga tcgttcccat 269641 tgcggcaccc cgtttatgag gcgggaaaat caccaagatt gtgttaaaca tcagcggcag 269701 taaaagaccg gttccaagtg cctgaacgat ccttgccgct aataaaaacg agaagctcgg 269761 cgcaagcgcc gcaatgaatg tacctaaaat tgaaaagata agtgacacgg taaaaagctg 269821 tcttgttgtg aaccactgca acagcagtcc tgaaacagga acaaggatac cgagtacaag 269881 caggtagccc gtcgttaacc attggacggt tgccgctgta atgttcaatt ccttcataag 269941 gtcggttaac gcaatattca gcgctgtttc actgaacatg ccgataaaac cggccaacag 270001 caaggaaatc ataatcggca tcactttgta ttgctgagat gctttagctg ttgtttccaa 270061 aatcatttcc cctctctatc aactgcatgt agtatgtcgt tttttttatc tcttcagcag 270121 gtcaggaatg cagctggaga tatgaaggag cggcgtactg ttttttgccg tcaaagataa 270181 aaggatgccg ccttcaatca tcgcgttaac cacagtgctg gcttcttttg cacggctctc 270241 gctgcagcca gtctgccgca gtttttcctc atacacagag gcccattctt tgtaggcttc 270301 atgacaggct tcgcgcaacg gttcgctttt caatgacgtc tcagccgcta gcaagcccac 270361 aggcaagcct tcaatgtctt ccgtacatga aaactggcag gagagctcct tcaaaaaggc 270421 ttgaatgcct tccgctggat cggtgcaggc ttccatgcag tccgcgattt tctgacggat 270481 atactccttc atctcattca cggcttcgat cgcaagctgt tctttacccc cgggaaagtg 270541 gtagtaaaga gagcctttag gcgcgccgct ttcctttata atctggttca gccccgtgcc 270601 gtaataccct tgcagctgaa aaagccgggt agctgccgaa aggattttct cacgggaatc 270661 tccataactc ataacattcc caccttactg aattgcaatc aaaaatatag tgactggtct 270721 attatcttga ttcaatcatc aattgtcaag aaaaattcat tgtatgaaaa gacaaaaaaa 270781 gaaggatatg acaacaaaaa atactgagag aaaagctgac tgatcttttg actgaataga 270841 taaaatgtac aatgattaat catcatatgg atgtaaggag agaaatagat gaaaaaacaa 270901 cgaatgctcg tactttttac cgcactattg tttgttttta ccggatgttc acattctcct 270961 gaaacaaaag aatccccgaa agaaaaagct cagacacaaa aagtctcttc ggcttctgcc 271021 tctgaaaaaa aggatctgcc aaacattaga attttagcga caggaggcac gatagctggt 271081 gccgatcaat cgaaaacctc aacaactgaa tataaagcag gtgttgtcgg cgttgaatca 271141 ctgatcgagg cagttccaga aatgaaggac attgcaaacg tcagcggcga gcagattgtt 271201 aacgtcggca gcacaaatat tgataataaa atattgctga agctggcgaa acgcatcaac 271261 cacttgctcg cttcagatga tgtagacgga atcgtcgtga ctcatggaac agatacattg 271321 gaggaaaccg cttatttttt gaatcttacc gtgaaaagtg ataaaccggt tgttattgtc 271381 ggttcgatga gaccttccac agccatcagc gctgatgggc cttctaacct gtacaatgca 271441 gtgaaagtgg caggtgcccc tgaggcaaaa gggaaaggga cgcttgttgt tcttaacgac 271501 cggattgcct cagcccgata tgtcaccaaa acaaacacaa ctacaacaga tacatttaaa 271561 tcagaagaaa tgggcttcgt cggaacaatt gcagatgata tctattttaa taatgagatt 271621 acccgtaagc atacgaagga cacggatttc tcggtttcta atcttgatga gctgccgcag 271681 gttgacatta tctatggata ccaaaatgac ggaagctacc tgtttgacgc tgctgtaaaa 271741 gccggagcaa aggggattgt atttgccggt tctgggaacg ggtctttatc tgatgcagcc 271801 gaaaaagggg cggacagcgc agtcaaaaaa ggcgttacag tggtgcgctc tacccgcacg 271861 ggaaatggtg tcgtcacacc aaaccaagac tatgcggaaa aggacttgct ggcatcgaac 271921 tctttaaacc cccaaaaagc acggatgttg ctgatgcttg cgcttaccaa aacaaatgat 271981 cctcaaaaaa tccaagctta tttcaatgag tattgaagaa aagaaggcga ataagccttc 272041 ttttttttgg ctttttagga ccaataatga cctctgaatc ttaaaatttc tttaaaaata 272101 agccaaaatt accctttact taattaattt ggtaacgtaa tataattgga gaatttgtta 272161 caaaaaaagg aggatattat gaaatttgta aaaagaagga tcattgcact tgtaacaatt 272221 ttgatgctgt ctgttacatc gctgtttgcg ttgcagccgt cagcaaaagc cgctgaacac 272281 aatccagtcg ttatggttca cggtattgga ggggcatcat tcaattttgc gggaattaag 272341 agctatctcg tatctcaggg ctggtcgcgg gacaagctgt atgcagttga tttttgggac 272401 aagacaggca caaattataa caatggaccg gtattatcac gatttgtgca aaaggtttta 272461 gatgaaacgg gtgcgaaaaa agtggatatt gtcgctcaca gcatgggggg cgcgaacaca 272521 ctttactaca taaaaaatct ggacggcgga aataaagttg caaacgtcgt gacgcttggc 272581 ggcgcgaacc gtttgacgac aggcaaggcg cttccgggaa cagatccaaa tcaaaagatt 272641 ttatacacat ccatttacag cagtgccgat atgattgtca tgaattactt atcaagatta 272701 gatggtgcta gaaacgttca aatccatggc gttggacaca tcggccttct gtacagcagc 272761 caagtcaaca gcctgattaa agaagggctg aacggcgggg gccagaatac gaattaatga 272821 aaaacaaaac cttgaagaat gctattcttc aaggttattc tgctttcagc acaatggttt 272881 tcgcagccat atcatgaacg gtttgttttt tcttcgtaaa tgcggcagtc aaatagatca 272941 ggcgggagaa cacatgcacc cacgctatca ggtaacggac aatggcttgc gggaaggata 273001 tttttttata tgtttcgtcc ctcacgattt gcagcccgat gatttttttg cctagtgtgc 273061 ccttccaatt tgtcagcggc atcagcaaag ggtacacaat cagcatcaat atggcgacaa 273121 taatgacacc ggcggaccca tcgccaaacg taaatccggc tgccaaaatc actgctgcgg 273181 caatgattac atcaagtaaa agagcgcagg cgcgcagcat gaaaccagct agttccaata 273241 gaaacactcc ttaaaatgtt aaataaacac ctaatgattg taaaaaagaa gggcctaaag 273301 tgggaatagg tgataagcct taaatcacaa aagttggtga aaatgtcata ggtaaattgg 273361 cataatcagc cagcttatca cattaccaaa ttctttttta gcccgaaacc aagccctcag 273421 aagttatttt tgttaaaata gaaaagttac aacagaattc ggagggttta ttgtgggaaa 273481 agtgaaacga aatgcccctt gcccatgcgg cagcggcaag aaatataaaa aatgctgcgg 273541 aagtaaagtt gtcgacttcc cggcggaact agcggcaaaa gaagcgaaac aaattcagga 273601 agacttagtg gagtatgcct tcacagtaca tagagaaagc atttcaggct ttatcaacca 273661 gcatgatttt ctttctgcta tggacagaca gacgaaagac atcagcgtat ttaacttagg 273721 aatctgggga atcttcttcc acccgcttgc tggtgagaag acaatcttcg aagagtacct 273781 tcagaaaaaa ggcgattcga tcactcgtcc gaaaacgcgt gagatcgtag aatcatggca 273841 gagcatgacg cctgctttat tgctgctgaa ggacctgaag gaaggcatca ttcactttga 273901 agatgtcatt acggcaaaac aattcgaagt ggaaatggac gccagcaatc aagaccttcc 273961 tccagtggga agcctgattc ttggataccc aatccacgaa gcggaaaaag cagaattctt 274021 catgcagttc acgatcttcc cggtgaagag aacagaagcg ctgatcagca aggtgaagaa 274081 atatgcggat gccgctgtga aggacggcaa aacgccggag gacttcatga agcaggaatt 274141 caacaacgtt ctgttcgcgt tgttagctga gaaagatgaa gagccacaag cagagaaagc 274201 ggaagtaagc actgttgagt gggcaaacga cttggagaaa gaaaccgctg cggctattga 274261 agaaggcatg agcggggaag agtatccgac tgaattgatc ccagctgtta ttgacatctg 274321 gaaaacattc tgcgagaaaa aatcacctgt catcagaaag ccggaagctt ttgcggcggc 274381 agttgaatat tatgtaaacg caatttctct taacggcgcg tccgtttccc aggctaaact 274441 ggcgaaaaaa tacggcgtta gcgcatcaac gatttccagc cgttacaaag aaattgaaag 274501 cacgctgcaa gatgaagcag atcgttttgc acaagcgtta tcctcataat ggaaaaaacc 274561 ttgaaaagcc aggcttttca aggttttttt atttctgaaa cggaattttg atttctaacc 274621 ggaagatggg gtggcggtag gtaaaatcca gcctgccaaa agcgcccttc accagttttt 274681 gaatgatata tgtgcccatg ccttcatgag cgccgttttt cgttgagcgg ccaaacgatt 274741 gataaattgt atcgagcact tttgggtcca tcccgggagt gctgttttca caagtcagta 274801 cataaagccc gctgcgcagt gaagtctcca gtttaatctc tgctttttct cgggcctccg 274861 ccgcgctgtc gagcgcattt tctaatatgt tgccgaccaa gctgacctga tcagcaggcg 274921 aaaacggaag ggaagaaagc ggtgtatgca tatgcagcga aacactcaca ttcgaggcgc 274981 gggctttttc taaaaaatca taaagcaccc ctgcaacgta cgcgttctct cctttcaaaa 275041 aacggtcata ttggctgtat tgatccgccc agttttgaat atatgcttgt gtatctgcct 275101 tgggctgagc tgatttgatt gcagtgatat gtttcattgt gtcatgattc cggcttctga 275161 catcaatcag catttgattg gcgtgctgtt cagcttgagt cagcttatca atttgatcag 275221 aaagccttgc ctgcaaagca gactgtccga tacggagccc ttcacaccct gcaaatatcg 275281 cgattacaca taataccggc atgatgtctg tgccaatcaa caccactccc accgacatca 275341 cttgaatcac cgcaatccac gcacaaagcc ctgaggaaca gtgtttccac acccgcttcg 275401 tattccaaat gtacaatcct gcagcagctg cgcctaaagc agcggcgagc caagaggcgg 275461 ctgtgctgtg tgaaaaagca gcagctccct gataacatat gaaactaaat aaaatcagat 275521 aaagacattg aaaaagggta atcacgtact aaactcctca aaaatagtag ttttgaaaat 275581 aatcaagctg ctgcttagtg atcatcgctt ttttagacgt tccctcaaag gaaactgtga 275641 atgaatgctt ggtataagcg gaaaaatgct ttatgtaatg aatgttgata ataaaggaac 275701 gatgcgaacg aagaaaatct ttttcgggca ggtcgccttt aatatcattt aatgtttgat 275761 acgtttgcac ctcttcggcg gttgtcacaa tcgtcgtcga acgtcccgtc cgttctgcga 275821 aaataatatc cttcttttgc aggacgtgca tttcagactt ttgctttatc aatatacgcc 275881 cattcaaact cgtttccgtt ttctttttca agtaccggtc gaaggaagcg gccagacggt 275941 cggcatagta cggcttcata atataatcat ggacgttcag gtcaaaggcg tgaaccgcat 276001 aaccgccgtg gccggtaaca aaaatcacat ccacatcaag tgaatgggat ttgatcaaat 276061 cagcaagctc gtagccagac atatggggca tctcgatatc ggcaagcagc agatcaatgt 276121 ctccgttctt tacccgcctg taggcttcct tcgctgaatc ggtggaaaag acaatttcga 276181 cgtcctgcat tctggacacg atcgcttcta acttctctaa atctactcga taatcatcta 276241 caagtccgac ttttaccatt atcattcccc tagttacata gaatcatctt tattctatcc 276301 catttcacga cataaaaaga actcttcgcg acaactttat ccaactaatc cagcttttcg 276361 tatatagtca ttactagaaa taaagataag ggagattgtg acatgattac actgaccgat 276421 tgcagccgca ggtttcagga taagaaaaaa gtagtcaaag cggtgcgaga tgtaagctta 276481 acaattgaaa aaggagaagt cgtcggcatt ctcggagaaa acggtgccgg caaaacgacg 276541 atgctgagaa tgattgcttc cttgcttgaa ccatcacagg gtgtaatcac agtagacggc 276601 tttgacacgg tcaagcagcc ggctgaggtc aaacaaagaa tcggtgtctt attcggagga 276661 gaaaccgggc tttacgacag gatgaccgct aaagaaaatc tccaatactt cggcaggctg 276721 tatgggctga accgccacga gatcaaagca agaatagaag atttatcgaa acggttcggc 276781 atgcgcgatt atatgaaccg gagagtgggc gggttttcga aaggcatgag gcagaaagtc 276841 gccattgcca gagcgctgat tcacgatccg gacatcattt tatttgatga gccgacaact 276901 gggcttgata ttacgtcaag caacatcttc cgcgaattta tacagcagct gaaaagagaa 276961 caaaaaacga ttcttttctc cagccacatt atggaggaag tgcaggcgct ctgtgacagt 277021 gtcatcatga ttcacagcgg agaggtgatt taccgagggg cgcttgaatc actatacgag 277081 agcgagcgca gtgaggattt gaattacatc tttatgtcta agcttgtcag ggggatttct 277141 taaatgctga gccatattta taaaaaagaa atgatcgacg ctttacgcga cagaaaaacg 277201 atattactca caatcttagt gccgatgatt atgatgcttg gacttgtctt tttttatgaa 277261 agcatgctgt ccgacaaagg ggagcagtac acgctggctg tcggccattc gcttccgccc 277321 gcactggaaa gcaagcttaa tgagattgac gaaatcagcg taaaaacatt tgcaaagcct 277381 gaagaggcag ttgatgaagg aaaagcagat gcctatctga acgtcccgaa agagttcgac 277441 tcatatgtca acagcatgac accttttaag gttgatgttt acggcaattc aatcgatcaa 277501 gggtcgtcaa atgccatgca gcttgtgcag tctgccttag atcagtacaa aaatgaaatt 277561 gtgcagcaac gtttaacaaa taagcatatt gatcaatcgg tgatccagcc gtttacaatt 277621 cagcaaaagg aagcggatga ggagaaaggg acttccgcta ttatgctttc cgccattctg 277681 cccatgctga ttctgacttc cattgtttcc ggcgcaatgc cgatcgctct tgatatcatg 277741 gccggtgaaa aggaccgaaa gtcaatcgag gcgctgctat taacgccagt cagcagaaac 277801 aaagtgctgg tcggcaagtg gcttgcggtt tccacttttg gcgtggcttc aggtgtattt 277861 gctttggtgt ttttgatttt gtccaccgtg ttatttaccg aaaatttaaa aacggccttc 277921 cagctgggag atcatatgtg gagtgtaatc ggcgcttcag ccttaatcat tgtgctctct 277981 gcattgctga tatctgcgat ggagcttttc atcagcatca tgtccagctc ggtaaaagaa 278041 gcgcaaagtt atatgtctct cgtcgtcttt ctgcctgtgt tcccgatgtt tttcatcttc 278101 agcaaggcac cgaaccaatt tgacttatca tactttctca tcccgtttct gaacctgcat 278161 gcgttattta aacagctttt attcgggatg gttgacccgg ctaccatttt gtctacgtca 278221 ggaaccatcg ccgtgctcat cgccatcttc tttttactag ccagagcctg cttcctgaaa 278281 gacaaatggg ttcttccaaa ataaacttgc gaaaggagaa atacactttc tcctttttgt 278341 atatcctgaa aaaagaagga aaatagaaaa aggatatcta atacaaaaag tgaccctgca 278401 ctatttttca tcaaaattgg tttcaaagga gaaggaacaa tggatcaaac acgtacactc 278461 ggcaaaacga agctgaaggt gaagcggatc ggattcggcg cgaatgcggt cggcgggcat 278521 aatctatttc caaatctaaa tgatgaaaca gggaaggatt tagtgcgcac ggcattggat 278581 ggcggcgtca attttatcga taccgccttt atatatggat tggggcgatc tgaagaatta 278641 atcggcgaag tcgtacagga acgcggcgtg cggaatgagc tcatcatcgc caccaaagga 278701 gctcataaag aagtggacgg cagcattgaa ttagacaata gccgggagtt tcttcgcagc 278761 gaggtggaga agagcctgaa gcggctgaaa acagattaca ttgatttgta ttatgttcac 278821 tttccggatg gaaaaacacc tctcgctgaa gtggcgggca ctttgaaaga gctgaaggat 278881 gaggggaaaa tcaaagcgat cggcgcttcg aacctcgatt atcagcaatt gcaggatttt 278941 aatgctgacg gctatttgga ggtcttccag gccgaatatt ctctcataca gcgtgatgcc 279001 gagaaagagc ttcttccata ctgtgaaaaa caaggcatct cctttattcc ttactttccg 279061 cttgcgtccg gactgctgac aggaaaattc acgcaagaca cagtctttga tgatttcaga 279121 aaggataaac ctcaatttca gggtgaaacg tttatccaca atctcaaaaa agtagataag 279181 ctgaaagcag tagcggagga aaaacaagcg gatacggcac atgtcgcctt ggcgtggctg 279241 ttaacgagac cggcgattga tgccattatt ccaggagcta aacgaccgga gcaattacag 279301 gataacctga aaaccttgaa cattgaactg accgaagatg aagtgaattt catcagcgac 279361 attttcaaat aaaaaaggaa atagccgtca tggctatttc cttttggtgt tttattcttt 279421 gatgaatgct tcgactaatt ctgctgctct gtaatcatcc atatcaagct gccattggtc 279481 gatgtcattt ttcttcattt tcacttcaac tgttttttca gatgaagcag gtccaagctt 279541 tttgaattcc tcaggataga cttgaagcgc gtatttcact gcctcttcat agctggcact 279601 agagttttta ctgtagtagt ctttcacttt gtcttcgatg cggtctgaaa gagaagatgc 279661 atctacaggt ttaactgtgg cttcaacaat tgcttcgtct ttagagattg aagtcgtttt 279721 tgcttgaatg gaagagtttt tgcttaatcc ctctttaatg ccgttcacga tattatcaag 279781 cgctttgctg tccgcatatg tgctggaaag gccggaagct gagagataac cgtctttggc 279841 tgattcatta aaatcattta caatttcatt tttgttagcg ccggtgattt tttcgaaatc 279901 ggcgttatct ttgccgaaaa gaaggacatc aacataagct gataacgctt ttgcagaatc 279961 ttggagctta tctgccgtcg ccaggatttt tttgtctttt ccgtcaattt taaaagtaac 280021 tgattttggc tttttatcac cgtaagattc cggcgtatag ttaagctcgt attgcttgcc 280081 tttatctaca acgaagaaaa gatttccttc aacggatttg tcagcgttaa tcgtgctgcc 280141 ctgaagcttt tcgctatagt cttcagggtc tgtgtcagac attttggtat caccttgata 280201 caatgtgaaa tccatactgt ctacattcag cgggtctttt cctgtgtttt tcaccgcgac 280261 attgactttt aacacaagct ggtcatctga agtggactta tcatatttag acggaagtgt 280321 gtaagagaca tccttgattt tgacttgagc tatatctgag cttttttctg tttctgattc 280381 tttcttctcc gcgcttgttt tgctgccgga acaagcagct gtaaacatca tcagcagaag 280441 aattaggaaa acagcgtacg tttttttctg aaacattcat ttttcctcct caaatggttt 280501 aggaaagggg agtcttttgt ctttgagaaa tggatctttt tgaatggatt agcatcatat 280561 aaccaaaaaa atcagttctt ttctcacggt tttcaccgga ttttctggaa actccgccct 280621 cctttgtcat gaatggacct ataaaaagtt acaacggaat taattttaag attattagct 280681 tttatattga ataggttcat catcctattt ttggtgaaaa atgttctggt aaaactggta 280741 aactcagaaa actgtgtatt ttagactatt actttttgat tagttggagg gaacttaaga 280801 aggatgaaag gggccgcctt tgtgaagaaa gagggactga aacaaaaagc actggaaatc 280861 ggccgggtgc cgacacactt aaaactggaa attgaagatt atggcggtga tgataaaaga 280921 gctcattttt gttgggcaga tcctcaggat gagaataccg gcattatcgt ggagcttgga 280981 ccggacggag agctggaatc cctttcccgt gatattgagc ctgaaagcgg agaaaggctg 281041 tctgaggaga aactagagga tatcatgcgc caatttgtcg agactcatca tccgggggca 281101 ctctctgcct ttgttcgtga agaaaatgac cgtgcatacg gcgataaagt gagattttca 281161 tatgttcaaa tggaggctgg gcttcctctc cccatgagcg gatttatggc tgatgtttcc 281221 ttatcaggtg agattgttta cttccgttat tacggcgaag cgggcagcat catcaagcca 281281 aagcgggtcg cggatgttga agaggcactt gcctttatca agaaggacgt ggagttcgac 281341 cttttgtttg aggttctcca tcgttctgtt tacaaaaacg gagatgatca gccgcatttg 281401 gtgtacgagc ctgaaggtag ggcgattacc gtacctgcgg atttggttca agaagaacaa 281461 gcagttgatg atgacgatga ttacagggag ccggagagct ttcctctccc tttattcgag 281521 ggcatccgcg aaaaggccga tcctgacagc atgattggta ttgaaaatgg gtttgtcaaa 281581 gagcgggaag cggatttggg agatgggaga attggaatcg tttggcggaa tccggatgac 281641 cctgtgtatc agccggcgga taaaagcatg gacagctggt ttaagggacg gactcatcaa 281701 gtgctgaaaa ccatctataa caaagaaacc ggaaaactcg aaggcgtcat gtcatttatg 281761 gagaaaaaag ggccgctgac agtaaccttg gcagagtgtg aaaaaatcgc gcttcgcttt 281821 ctatttgctt tatttccgaa tgccgatcaa tattttagga tcagatacga cgaaaaagat 281881 gaagaagaaa acgcagtcgc tggttttacg tttgaagcgc attgtcacgg agttccgctc 281941 cgatttgggc agatcagaat ttgtgtcagc cgccagacag ggtatatcac cgtttatatg 282001 ggaccggata ttgacccaaa taagctggca accattgatc ctgtgccggc tatttcagtt 282061 gaacaagcca agtctatctt ttggcagcat tttaaagttg agcttggctg ggaaagagag 282121 tacggggatg atgaagaaca cagctaccgg ctcgtctata agccggtgta tccgcatttt 282181 atcgatgcac atacagggga gcctgtcttc agcatatggt gaaacagcca aaagtcacgc 282241 aattgcctca gatatagaag agagtatgtg atgaaagtaa cagaaagaat ctcaaaaaac 282301 aatgacaata atagaaaagg acctttcttc actttaaatg aagaaaggtc tttttatata 282361 ataaacagga ttctctttgt cgtagactct ttgaaaggga tgacttcatt ggttaataaa 282421 cagctgaaaa agaaggcgca ggagatcgga aatgtaccga cgcattatga gcttgagata 282481 gaagattacg accaaaagca aaagaagtac gggcaggcat attttatctg gaaggaccct 282541 aaagatccgg aaaagcacat tacagttgaa cttagaaatg acggcgcctt gctcaccttt 282601 tcaacaactg tccactccga gacagacaaa aaacttccag atgccgagct gaagctgacg 282661 gctcttcagt ttgccgctgc caatcatccc ggcacattta tgaattttca ttttcaaggc 282721 aaggaagaaa gggggcagca catccggttt gtctatacca aaatggagct ggggcttccg 282781 attcccaatt caggcttttt aattgatatg acacgaagcg gtcagattgt ccactttcta 282841 tattacgggg aagggcataa agccgaagtt ccgacggaat ttgtagcaaa agagaaggtt 282901 gtatcccatt acttaaacac aatgtctttt gagctgatgt acgatgtcat tgatggcgaa 282961 caggaaccaa ggcttgtata tgaaccgatt ctaccgggat acagctatcc cgcagatgta 283021 gacgaaattg tgcccgacca gcatatcgca gatgaaagaa tagaaaacac ggcgccactg 283081 ccgccgcttc agaacaagga agaagttgat atatttgcct tgctgggttt tacctctgat 283141 atgcagaaag tcagtgaaag agactttgga gaacaaattg gaagcacgtg gcgcaggggc 283201 gctgcgccgg agcgtaagga tttaagcata ggaagctatt ttgaaacgag aaataaaaat 283261 acaatcaaaa tgaagacgga taaaagaacc ggaaaattaa aagcagcgct ttcttttatg 283321 gactggcgga acaacctcca atgctccacg gaagaatgcc aagagatagc gcttcaattt 283381 ttgtatgccc tctatccgag agcggctgag tttttcaggg tgaatcccgt ccgaattgat 283441 gaaagaggga gagtccgcaa ccatttttct gtctggtata aaggagtgcc gctgcggttc 283501 ggcgctgccc gcatcattgt caatccggaa actgggttga ttgacgcttt tatggcgcct 283561 gatattgaac ctgaacaatt ggaagcgata aatcacaggc cggatgtttc cgctgaagaa 283621 gcgaaagaag catttttagc cgcttttgat gtgaaactgg aatggcagcc tgattttaca 283681 gcaggcagtg accagcactg caaacttgtc tataagccgg tttacccttc ctatattgat 283741 gcgcacataa ggaaaaagaa aaggctgtga ggggtgtcta gttaggaatc atctccaagt 283801 gggggtagtc cttgaatcgt ttccaatccc cgccccattc gaaaccgagt gtcttagcga 283861 tctcgacaac ctccagccaa tctgattttc cgttttgatt gccgtcatat tccatatccc 283921 atatgatgct gccatccttt ttttgaaggg cgaaatcaat cgctaaacca tagttatgat 283981 acgattcccc tcctcttgca taggtgacaa tattcccttt ttttgtacgt ccctgtttat 284041 ataattcatc ttgttcctta aaggacctga atccttcagt aatgacgacg tcaatgcctt 284101 tattcgctgc agcggctttg agtgcatcgg cattctgctt cacaatcgga tgaagatccg 284161 aggggacagg catgtcctgc aaggcgtttt gagaatgcca ttcatgccga atataactaa 284221 aacaaagatc tagaagaaat agaatacata agataacaaa tgtttttgcg ggtaagttca 284281 tatcggtctc actttctcaa gatgtgctga atgttaacgc ttttaagtga ttgactctct 284341 ctaaaagcga acagctatga taaaatataa cataaatagt agcaggagga aggaggcaga 284401 ccgatgagag caaagattcc atcagaagaa gtagcagtaa agctgaatga atggtacaag 284461 ctcattcgcg catttgaagc agatcaagca gaagcgttaa agcaggagat tgaatatgat 284521 ttagaagata tggaagagaa tcaggacttg cttttatatt tttctttgat ggaattccgg 284581 catcgaatca tgcttgataa gctgatgccg gtgaaagaca gcgataccaa gcctccgttc 284641 tctgatatgc tgaacgaaat tgaaagcaat cagcaaaaac tcacgggctt actggaatac 284701 tacttttatt atttcagagg aatgtacgaa ttcaagcaga aaaatttcat attagcgatt 284761 gaccattata aacatgccga ggaaaagctc gagtatgtcg aggatgagat cgaaaaagct 284821 gagtttcttt ttaaagtcgc agaagtgtat tatcacatca aacaaacgta tttttccatg 284881 aattatgcga gccaggcgct tgatatctat acgaaatatg aactgtacgg tcgccgccgg 284941 gttcagtgtg aatttatcat cgccggaaat ttgaccgatg tgtatcatca tgaaaaagca 285001 ctgacccact tgtgcagcgc tttagaacat gccaggcagc ttgaagaagc gtacatgatc 285061 gctgctgcct attataatgt cggacactgt aagtacagtc tgggtgatta caaagaagcg 285121 gagggctatt tcaaaacagc cgccgccatt tttgaggagc acaactttca gcaagctgtt 285181 caagctgtat tttcactgac ccatatctac tgtaaagagg gaaaatacga caaggcagta 285241 gaggcttatg accgcgggat aaagagcgcg gctgaatggg aggatgacat gtacttgacg 285301 aaattccgcc tcattcatga gctgtatctt ggaagcggcg acctgaacgt gcttacagaa 285361 tgctttgacc tgctggaatc caggcagctt cttgctgacg ccgaagatct gctgcatgat 285421 acagcggaac gtttcaatca gttggaacat tacgagtccg ccgctttctt ttaccgcagg 285481 ctgatgaata ttaaaaagaa gcttgccgag cagcgttttc aataggaaat ggcagagaac 285541 tacaggttct ctgctttttt tgtgctgttt tcaactcgga aaaacagggt attttccact 285601 gcatagtgag aaacagagga ggatatcaag tatgtacaaa gatttaaccg gaaaaacagc 285661 gattgtgaca gggtcttcaa aaggaatcgg gaaagccatt gcggaacggt tcggaaagga 285721 gaaaatgaat gttgttgtaa attaccacag cgacccgtct ggagcagatg aaactctgga 285781 aatcattaag cagaacggag ggaaagccgt ctcagttgag gcggacgtgt caaaagaaga 285841 ggggattcag gcgctcttgg acacagcttt agagcatttc ggcacgctcg atgtgatggt 285901 aaacaactcc ggttttaacg gcgttgaggc gatgccgcat gagatgagtc ttgaagattg 285961 gcagagagtg attgatgtca atgttaccgg aacctttctg ggagcgaaag cagcacttaa 286021 ccacatgatg aaaaacaata tcaagggcaa tgtgctgaat atctcaagtg ttcatcagca 286081 gattccgcgc cctgtaaacg ttcagtattc cacatccaaa ggcggcatca agatgatgac 286141 ggaaacgctg gcgctcaatt atgcggataa gggaatccgc gtcaatgcga tagcgcccgg 286201 caccattgcc acagaatcaa atgttgatac gaaaaaggaa gagagcaggc aaaaacaatt 286261 gaaaaaaatc ccgatgaaag ccttcggaaa gcctgaagaa gtggcggcag cagcagcttg 286321 gctcgtatct gaggaagcaa gctatgtgac cggcgcaaca cttttcgtcg acggcggaat 286381 gacactttat ccatctcagc ttgaatagaa gacaaaacag ggggattgcg ggatgaaaac 286441 agactggtgg aaggatgcag tggtgtacca aatttacccg agaagctttc aggacagcaa 286501 tggagacgga attggggact tgcgggggat tatttcccgt cttgactaca taaaggagct 286561 cggggcagat gtgatttgga tttgcccgat ctatccttct ccgaatgttg attacggcta 286621 tgatgtgaca aaccataagg cgattatgga ttcttacgga acaatggacg attttcacga 286681 gctgctggac caggtgcatc agcggggatt aaagctggtg atggactttg tgttaaatca 286741 cacctcggtc gagcatccgt ggtttaaaga agcggagctg gacaaaaaca gcaaataccg 286801 tagctattat tattggcgtc ccggcacaaa gaacggcccg ccgacggact ggctctcaaa 286861 ctatggatgc ccggtctggc aatacgaaga gcacaccgga gaatactatc tccatatgaa 286921 tgccgtcaaa caagctgatt taaactggga aaatcccgaa gttcgccagg cggtgtatga 286981 catgatgaaa ttttggctcg ataaaggggt cgacggtttg cgaattgatc agctccatct 287041 catttctaag aaagaatatc ttccttcgta tgaggactat atcaatcagc aggcagagcc 287101 gaagcccttt cagccaaatg gcgaacgaat ccatgactat ttaaaagaaa tcacagatga 287161 agtgttttct cattatgatg tcatgtctgt cggagaggtc ggcagtgtca caccggaaga 287221 aggcctgaaa tatacgggaa cagataagca tgagctgaat atgatttttc actttcagca 287281 tatggagctt gatcagcagc ccggaaaaga acattgggat ttgaagcccc ttgagctttc 287341 tgatttaaaa tcggttttga caaaatggca aaagaagctt gaacatcaag gctggaatac 287401 attgttttgg tgcaaccacg accagccccg gattgtgtcc agattcggag acgatgggga 287461 ataccgcaaa gcatcagcga aaatgctggc agccgtaatt tattttatga agggcacgcc 287521 gtatatttat cagggagaag aaatcgggat gacaaacgcg ccgttcaccc ggattgaaga 287581 ctacaaagat atccaaacga tcaatatgta tcataaacgg gtgtttgaaa aaggctatga 287641 tccaaatgat gtgatgagat cgatcttagc caaaagccgg gatcacgccc ggaccccgat 287701 gcagtggaac agcggcaaaa atgccggatt tactgacggc acgccttggc tgaaggtcaa 287761 tccgaacttc accgcaatca atgtggagga agcgcaggga gatcctgatt ctgtcttaaa 287821 ctattacaaa aagctgatca gcctgagaaa gcagtacgct gacctcatga aagggagctt 287881 tgatcttttg cttccggacg atccgcagtt gtttgtatac atgagagaaa acagtaaaca 287941 acagcttttg tcggtcaata atttttcaaa agagcaggct gtttttcagt ggcctaagaa 288001 ctgcggcaaa gctcaggcct cactgcttct cagcaattat aacaacgatg atcttgatga 288061 cgaaatggtg ttccggcctt atgagagcag ggtctatctt ctggacaaaa caaactaatg 288121 attgaagtag cccggcattt ttagccgggt ttttttagta catatattcg ctctgcaggc 288181 gggaagaata aatgaaaatg aaatttattc ttgcaaaacg taatgacttc ggtttattat 288241 gatataggat tacaaaatcg ttatcatttt gatttaaagt tactgaaaaa gaggggatat 288301 acgatatgtt taaaaaatgg agcggtttgt ttgtgattgc agcgtgcttt ttattagttg 288361 cagcatgcgg caactcatca acaaaagggt cggcggattc aaagggtgat aaactgcacg 288421 ttgtcacaac gttctacccg atgtatgaat tcacaaaaca aattgtaaaa gacaaaggcg 288481 atgtggatct gttaatccca tcttccgttg aaccgcatga ttgggaaccg acgccgaaag 288541 acattgccaa cattcaggat gctgatttgt tcgtttataa tagtgaatac atggagacat 288601 gggttccgtc agctgaaaaa agcatgggcc aaggccatgc cgttttcgtt aatgcaagca 288661 aaggcattga tttaatggaa ggctctgaag aagaacacga agagcatgat catggggagc 288721 atgagcacag tcatgcaatg gaccctcacg tatggcttag ccctgttctg gcacagaagg 288781 aagttaaaaa tattacggct caaatcgtga agcaggaccc ggataacaaa gaatactatg 288841 agaaaaatag taaagaatat attgcaaaac tgcaggatct tgataaacta tatcgtacaa 288901 ccgcaaaaaa agcggagaaa aaagaattta tcacgcagca tacagctttt ggctatctgg 288961 caaaagaata cggcttgaag caggttccga ttgcagggct ttcacctgac caagaaccga 289021 gcgcagccag cttggcaaag ctgaaaacat atgccaaaga acataatgta aaagttattt 289081 actttgaaga aattgcatcc tcaaaggtcg cagatacgct cgccagtgaa atcggcgcga 289141 agacagaagt gctgaataca ctggaaggct tgagcaaaga agaacaggat aaaggtttag 289201 ggtatatcga cattatgaaa caaaacctcg atgccctgaa agattcacta ttggttaaat 289261 cataagatag tgtgcgccgg aggggtgcac actatttctt tgtgagaaag gaagattaac 289321 atgaatctcg tctcattgaa agatatcgtt ttcggctatt cccatacgcc tgttttagat 289381 aaagtatcac ttgatattga aagcggtgag ttcgtcggca tcactggacc aaacggcgcc 289441 tctaaatcga cgctcataaa ggtaatgctc ggcatgctga aaccgtggga aggcacagtg 289501 acgatcagta aaaggaatac agaagggaaa cgcctgacca tagggtacgt cccgcagcaa 289561 atttcttcat ttaatgccgg atttccgagc acggtgctgg agcttgttca gtcaggccgc 289621 tatacaaaag ggaaatggtt taaacgttta aatgaagaag atcatcttga agtagaaaaa 289681 gcattgaaaa tggtggaaat gtgggacctc cgccatcgta aaatcggtga tttatcaggc 289741 ggacagaaac agaaaatctg tatcgccaga atgctcgcca gcaacccgga tctgctgatg 289801 ctggacgaac cgacgacagc tgttgattac gacagcagaa aaggatttta cgaatttatg 289861 catcatctcg tgaaaaatca caaccgcaca gttgtgatgg ttactcacga acaaaacgaa 289921 gtacagcaat ttttagataa agtgattcga ttagagagag gagaaaaagg cggatggaaa 289981 tgtttgactt ggaattcatg cgacgagctt ttctagcagg cggcatgatc gccgtcatgg 290041 ctccgatact aggagtgtat ctcgttctca gaagacaggc cttaatggct gacacacttt 290101 cacatatctc attgtcaggt gttgccatcg gcttttttct cagcaccaat ataaccgcag 290161 caagcatagt cgtcgtgacc atcggcgcga tcggaattga atacatgcgg cgggcgtatc 290221 ggacttattc agaagtgtcc attgccatct taatggcagc tggtttgtcc ttcgcgatgt 290281 ttttaatcag cctttccaaa ggcacagcca atatgagcat cgatcaatac ctatttggat 290341 cgcttgtgac agtaaaccag cagcaggtct atattatcag tattatcaca ctgctgatcc 290401 tgctttattt tattgtactg agaaggccgc tctacctgct gacgtttgat gaagctacag 290461 ccaaaacatc gggaatcaat acaaacgttc tctcgttgtc attcagtatt gtcacaggcc 290521 ttgcgatttc agtcattatt ccgatcatcg gggtccttct tgtatcggcc ctgctcgtat 290581 tgccggcagc cttcgccatc agaattgcaa aaggctttaa catggttttc attacagcca 290641 tactcatttc attattcagc gtatttacgg gactgacatc atcctatcag ctcgggacgc 290701 cgccaggtcc gtctattacc ctgctattga tcgttttgct attaatcgga tttgcagttc 290761 agggagtttg gacgtttatc aaaaaagaag ctcagcgcaa aaaaagaagc cgataacatg 290821 aaaagcagtt ttccctaggg aaaactgctt tttttataga aacaattcgg caaggcgctc 290881 ataagattct tttttcgcct caaaatcaaa cacattgcac agaaccatga tttcatttgt 290941 ttcgtagcag cctgtgaggt ctaacagctg ttgtttgaca gtggtgggag aaccgatcac 291001 catccgcttt ctgttttctt ctatgagttt tttatcggac gctgtatagg gatgagcttt 291061 cgcttcctcg atgcttggca cgcggctgtc caagcctttt ccgacgcgaa gaagccacag 291121 atcctggctt aatgcgagtt cttctgcctc ttcatctgtt tttgcgcaaa tgacaaaaat 291181 cgtaaacagt gcggatggat tcgaaaaatg ggctgagggc cgaaagcttt cccggtagat 291241 gcggaatgca ttttctcctc gctcgggatt aatgaaatgc ccaaatacat atccaatccc 291301 ctggtgcgcc gcgcgtcttg cgctgttttc accaagaccg agcacccata gctcgggtgc 291361 cgtaccaata aggggcgccg ctttgattcc ggcatacgga tggtcgggag gaagggaatc 291421 tgttagaaaa taagagacat cctgcagctg tctgttaaat tcggttaagc tttttttcac 291481 cccgtccgtt aatgcaagtc tggtttttgt cgtgccgccg ggggagcgac cgacgccgag 291541 gtcaatccgg tttggataca gggcctcaag ctggcgaaag gtttcagcca ctttaaatgg 291601 gctgtattgg ggcagaagca cgccgcctga tccgacacga atggtgtttg tctgtgctgc 291661 gatgcgggcg atcatgattt caggcgctgt gcttgccagt cctttcgtgc tgtgatgctc 291721 ggcaaaccaa taacgcttat agccccactg ttcgcttaat tgggcaagct caaccgaatg 291781 ctggagagtt gtcacagggc tttctccttt agaaacaggt gcctgatcaa gtatgcttaa 291841 atgaatcaaa aggccgcttc ctttctgtct gtttttagat ggtgacacca gaataggcaa 291901 aatgacttgc ccgcgtcaaa tggtttgttt aagaagcgca ctttatagca tttgcaaatc 291961 atatatcaaa tatggaagtt ttttttcgag gtttttcgtc aattattctt aacttttacg 292021 aaactttgat ataataacaa acgtatatat tagtaattta cggcttattt tccttgtgag 292081 cgtaaaaata aatgtgacta tcttcacatt ttgatgagta ggagtgaatc gtgtggcaat 292141 ttctttagaa aaaggtcaac gaattgattt aacaaaagga aaagccggtc tgtcaaaatt 292201 gatggtcggt ctcggctggg acccagtgtc ctcaggcgga ggattcttca gcaaactgct 292261 tggcggaggc ggtccgaata tcgactgtga cgcttcagtg ctgatgctgg aaaacggaaa 292321 attcaccgat aagaaaaacc tgatttattt cggcaacctg aaaagccgct gcggcggtgt 292381 acagcataca ggcgacaacc tgacgggtga cggtgcgggc gatgacgagc aaattatgat 292441 agatttagat aaagtgcctg gaaacatcga taagcttgta tttgtagtga acatttacga 292501 ttgtgtcaga agaaaacaag atttcggcat gattcaaaat gcgtttatcc gcgtagttga 292561 tcaatctaat cacgaggaaa tgctcaagta caatttgaga gacaattacg ccggcagaac 292621 aagcctgatt acagcagaaa tctaccgcag cggcagtgag tggaagtttg cggcggtcgg 292681 tgaaggcaca aacgatacga gattagaaga tattatcagt cgatacgtat aaaagaaaag 292741 gagtggatga aacatgacaa tttcattggc aaaaggacaa aaagtagatt taacaaaaac 292801 aaatccgggt ctttcaaagg ttgttgtcgg tttaggctgg gatacgaaca agtatgacgg 292861 cgggcacgac tttgatcttg actcaagtgt gtttctgtta gacgccgcgg gcaaatgcgc 292921 gtcaccaaac gactttattt tctacaacca gcttgaaggc ggcaacggtt cagtcgttca 292981 ttcaggcgac aacctgactg gtgctggcga aggcgacgat gagaatgtaa aagtaaatct 293041 cagcgctgta ccggcaaaca ttgataaaat ctcatttgtt attaccattc acgatgcaga 293101 agcgcgcagc caaaactttg gacaagtatc aaacgcgttt gtccgcatcg taaatgaaga 293161 aacaaatgaa gagctcatcc gttacgatct tgcagaagat ttctctattg aaacggcaat 293221 cattgcaggg gagctttaca gacataacgg cgagtggaaa ttctcagcaa tcggctcagg 293281 ctaccaaggc ggccttgccc gcattgcaac agactacggt ttgcaagtcg gttaagacaa 293341 atacgaagag cagaaaggag agaggcagta tggccattca attatcaaaa ggacagcgca 293401 ttgatttaac aaaaacaaat ccgggactga ctaaagcggt gatcggctta ggctgggata 293461 caaacaagta ctccggcgga cacgattttg acctggatgc ttcggccttt ttagttgatg 293521 cgcatgataa ctgcgtaaat gatctcgatt tcgtcttcta taataacctt gaacatccga 293581 gcggcggtgt catccatacg ggtgacaacc gcacgggtga gggcgacgga gatgatgagc 293641 agattatcgt tgatttctca aaaatccctg ctcacattga gaaaatcggc atcacagtga 293701 ccattcacga cgctgaagca cgcagccaaa actttggaca agtttccaat gcatttgtcc 293761 gcgttgtgga tgaagaaacg cagaatgagc ttcttcgctt cgatttggga gaagacttct 293821 ccattgaaac agctgttgtc gtttgtgagc tttacagaca cggcggcgag tggaaattca 293881 atgcaatcgg cagcggattt tccggcgggc tggctgcatt gtgccggaat tacggtttgc 293941 aagtgtaagc gagtgacaaa tagagaagtc accgtttcaa attataggag gaaaaaactt 294001 ggacttttta catcatattt tgtctacgta tgcttcattt ttcgattgga aaatgtgggg 294061 ggaagttctg actgatcctg tttcctgggg tttgatcggt tcccttgttg ttctggaagg 294121 ccttttatcg gccgataacg cgcttgttct tgcggtcatg gttaaacacc tgccggaaaa 294181 acagcggaaa aaagcgttaa cgtatggttt gtttggagct tatattttca ggtttatttt 294241 catcgggctc ggtatgcttc tcattaaatt ctggtggatc aaggtgcttg gcgcgcttta 294301 cctggcttgg ctcgtcatta agcacttctg gataggcgaa aaagaagagg aagcggacgg 294361 catgaagaaa aactcttgga tggtccgcac gttcgggatc ttctgggcga ctgtcatttc 294421 agtagaatta atggatcttg ccttctctgt ggacagcatc ctggccgcgt ttgcagtatc 294481 tgaaaaagta tgggtgcttc tgattggcgg tatgcttggt attttaatga tgcgtacagt 294541 ggcaaaagtg ttccttgtgc tgattgataa aattcctgag ctggaaaaca cagcattcgt 294601 cttaatcggc attatcgcgc tgaaaatggc ggggagcgct ttccattacg aaatgccgca 294661 ctctgtattc ttcattatca ttatcgctgc atttgcggta acattgatca ttcactacat 294721 caataaacaa aagcaggtgc gcgaacaaac agccgcttca aaagaagaat aaaacaaaac 294781 aaggagggag gttcaatgtc cttccttttt tgttaccgaa atatcgtttc aatgacaaac 294841 cggaaaggag gatatgatga gacaagaaga actaaccatt cataaagcac ttccggctga 294901 tggcgattgg aaaagcctgc tgtttcagcc attgccggag cgggatcact atgaaactgc 294961 acaaggcctt tctttttctc gtcttgccgg tcagatattg ggcacgccta ttgatgagac 295021 ggactactat aacgagctgt atgagctgtc tgtaaacgac cgcataacga ttttgagtga 295081 aacgcttgat aaaacaatcg aaccggaaac atttcaaaag cttcagcata ttcattccat 295141 caatcagaaa gaaaaagggc tgtcagtcag ccgctttgtt gcctttctgg acggggaaaa 295201 gctgattgcg aagcactcaa atcccttgat gcaccgccat ttaagaaaag cgttgatgac 295261 gcttttacat acctttgcgg acagtcatga aaaggggctg aatcatcctg attttcgcag 295321 agtgctgctt gatgtctcga agttttcctt aaaccatctg aacccttggc tggaaaaaac 295381 cgatatagag cgggagatgc cgaaggttgt ttggtatgga gatgcgacga aaagccagct 295441 ctatttctta tattatctga tgctggtcgg ctgtgatgta ctgctgttcc atccggcggg 295501 aacggatcag ctggcgcttg tcgacccgaa gcaggagctc ggttttacgg aaaagctccc 295561 ggatgtttcg gagcttcagc cgtttccgaa agaaaaacca gaccggaaat caacagtggc 295621 ttaccgctca acaaaggaaa ttgaacatgt gctgaatcac gaggaatcca tgctatataa 295681 gccgtggcag ttcagagatc acacaccggt gtccgttacg ctgaaaacga cctatgatga 295741 attgttttta atcacgaaag aacgcgcctt tattcggccg aatttcaaag ctgataaaca 295801 ttccattgag attccgaatg tattcgccaa aattatgggc gtgtcgaaag acaataagga 295861 atattggaac aggcttcata ctctagcgga ttatcaggaa acagaaatgg tcagaagctt 295921 tccatttaca gaagaaataa agtcgaacta tcaatttcac tacagccacg cacttgatca 295981 agaagggaac attgatccgg acaagctgat ggcaagcaat gtgtggcagt acaaacagct 296041 gccggcgggc gttcagactg ccattgccaa aacgatttcg agaatgtgca ggtacccgcg 296101 gcttaaagcc ttgcatcagg aacaagtcaa ggatgttcaa atctatttgt ttaaacaaac 296161 aacaaacctg cctgctaatc tgctgaaatt gattcaaatg ttcgactatg cgcaaaccgt 296221 tccgaaactc gttttatatc atacggaaat gagcggcgga ctcacgcgtt cggatgctgc 296281 cgccctgctg ttcctgaatg aaatcggaat cgatatcatc atttataatc cgcccggaca 296341 ccaagatatt gagcagttta ttgaagagga tcagtatgat atccactggc tggatgacat 296401 ggtgtttcag caggactaca aagagccttc gcttgtgaaa aggctcttca gaaccattac 296461 ccaaaaataa ggagagaaga aaagcatgac aacagaaaat caaaatccgc ttgttctcga 296521 taaaaatgaa gagatttccc agcaaaaagc tgacgatatc cgtcttcagc tccgtcagga 296581 accagaagtg aagcggcttg ctcaacaaat tgacgtcaaa aaccaaatgg agctgcttga 296641 gtacggcaag gagccggccg ttgaaatatc caagttctct gaccgcatct tggggatgat 296701 gaaaacaaca agcgtgacag actccggcac aatgctgact cagcttggga aaatcatgga 296761 ccgcttcgac aaaaatgatt ttgatgagcc aaagggatta atggcgaaaa ttttcaaacg 296821 cggcggcagc atgattgaaa aaatctttaa aaagtatcag acgcttggcg gagagattga 296881 aaaaatccac gttgagattt caaaatacaa agatgagatg acgaagacga actacacgct 296941 cgatgaaatg tatgaaaaca atatcaaata ctatatggag cttgaaaaat acgtcgttgc 297001 cgggcagatg aaactggaag agatgcagtc gatccttcct tcatatgagg aaaaagcggc 297061 aagcgggaac cagctggcgc aaatgcagct cgatacgttg cgcaacggca ttcaggcgct 297121 tgaggaacgg gtgtatgatc ttgacatggc acggatggtg gcgcttcaaa ccgcacctca 297181 aatccgtctc ctgcagcgag gaaatgcaaa gctgatcggg aaaatcaact ccgcgtttat 297241 cattaccatt ccgattttca aaaacggcat tattcaggct gttacggtaa agcggcaaaa 297301 gcttgtggct gattccatga gcgagcttga ccgccggaca aacgagatgc tgaaacgaaa 297361 tgctgaaaac atctcgagcc aaagtgttga aattgcgaga atggccggca gaccgagcat 297421 agatattgaa acgattgaat cgtcttggaa cacgattgtc agcggcatgc aggaaacaaa 297481 acaaatcgaa gaagaaaaca agcgcctccg cgaagacggc gcgagacgaa ttgcccagct 297541 tcaggataat attaaaaaag cagcattgca gcaataataa aaaccccgct tgtggaacat 297601 aagcggggta tttcaattac atcatttagt taatgacaat gtgtaaagac aggtgtaaac 297661 ttaaacggta atcattttgc atatcagagg tgttggcaat gggaaaacaa cagcctatat 297721 cccagcgtaa actgctgggc gtcgccggtt tggggtggct gtttgatgca atggatgtcg 297781 gaatattatc gtttattatc gccgcgctcc atgtagagtg gaatctgtcg cccgaagaaa 297841 tgaaatggat cggaagcgtc aattccatcg gcatggctgc gggtgcgttt ttgtttggtt 297901 tgcttgctga tcgaatcggc cgcaaaaaag tgttcatcat caccctttta tgcttttcca 297961 tcggaagcgg catttccgct tttgtgacga gcttatcggc atttctaatc cttcgtttcg 298021 tgattggtat gggacttggc ggcgagcttc cagtcgcttc aacactcgtt tcggaagcgg 298081 ttgtgcctga aaagcggggc agagtgattg tgcttttgga aagcttttgg gccgtgggct 298141 ggctcgcagc ggccttgatt tcttactttg tgataccaag cttcggctgg caggctgccc 298201 ttctgttaac tgcgctgact gctttttatg cgctgtacct gcggacgagt ctacctgatt 298261 cgccgaaata tgaatcgctt tctgccaaaa agaggtcgat gtgggagaat gtaaaaagcg 298321 tctgggcaag acagtatata cggccgacgg tgatgctgtc gatcgtttgg ttctgtgtgg 298381 tgttttctta ttacggcatg ttcctatggc tcccgagtgt catgctgctg aaaggcttca 298441 gcatgattca aagctttgaa tatgtcctgc tgatgacgct tgctcagcta cctggctatt 298501 tctctgccgc atggctgatt gaaaaagcgg gccggaagtg gatactcgtc gtttacttga 298561 ttggcacagc aggaagcgcc tatttcttcg gaacggcgga ttccttaagt cttctgctta 298621 cggctggagt gctgttatcg tttttcaatc tcggtgcgtg gggcgtgctg tatgcttata 298681 ccccggagca atacccgact gcgattcgag caacaggttc aggaacgaca gcagcgtttg 298741 gaagaatcgg cggcatcttc gggcctttgc tcgtcggaac cctggcagcc cgtcatattt 298801 cgttttcggt catcttttca atcttttgca ttgcaatctt acttgcggtt gcttgtattt 298861 tgattatggg gaaagaaacg aaacaaactg agctagaata ggaaaagcac ctcttaaaag 298921 aggtgctttc agcgtgtcga caaaccctcg cattcgttgt caggactgcg cttcggtgct 298981 caatgcgaag tggatcaacg gctaaattct caggcgtcct gcctaaacgc cgtcgtcatc 299041 acatcctgtg aatgtccgct cctatgctcg tccttcctag acttcaaggg ttttcaatca 299101 cgctgaaaag attttgtcaa caatctgagg cacctcttga atgaggtgct tttttacaat 299161 tgcgcccggg ctgtggattg gcgtttcccg gttttactga ttgtctggta gagcgtcata 299221 gaaagtatga acagaatggc agtaaatcct gtgacagctc cgaaatgctg tgtgctttga 299281 tataaaaaac ctgcaatact tgtaccgaca gtggttccgg catacatagc ggcattggaa 299341 agggaagcga tggttcctcg cgcatttggt gcaatggatt gaaagacacc catcattaac 299401 ggaaagatga tgccagctgt aaagaacgtg agaaaaaagc cggcttctac taaaaacaag 299461 tttggaaaga acggaagagc gaaatagaga gcgcccatta gcagcatccc gctgatcagt 299521 gttttaaaca tgcccagctt ttctgaaacc cggctgccga taaggctccc gagcatattt 299581 cccagtccga gtacaagcat agctgcgcca atttgtgaca cggttaaatg ataatccgcg 299641 gaaagccaag tacccagaaa gctgaacgat gcgaagtttc cggtttgaaa cagaaaatag 299701 gcaagcagaa tgaccgatgt tttcggcaat gaaaaaagct cccgataggg gttgacaatt 299761 gatgggcgcg ccaatggttc agaaggccgg atgccaggca tgaccgccgc caggatcaat 299821 agaagaataa gcgagcacgc tgacaaaacg aaaaatggcg tatgccatgt aaaggaagcg 299881 agaaaccctc caataggaag tccgagcatt tgtgaagcgg ccaaacctgc tgtcgcaatc 299941 cccatgcctt ttatgatctg agaaggctgg acaatgactg ggatggacgc ccaaatttga 300001 ggcgtcacaa acgcagcgct aacgcctgcg gcaaaacgga acaggcacat ggcggcaaaa 300061 gagggagcga tgccgcataa aaatgtggat acgataaagc ctgcaagtcc ccacagcatg 300121 actgttttcc tgttcagccg gtctgagatt gggcctgcaa tgaaagcgaa gagtgcataa 300181 ccgagtgcat aagcactgac catccagcct gacaaatcag tagagacatg aaactgatcc 300241 tgtaaaaggg ggagaagcgg cgaaagcaaa aaggtatccg tgccaatgac aaacatgaca 300301 ctgaagaaaa gccaaatgcg attcaaattt tatcactcct attgttttat aactttaaaa 300361 ctatgaaaca gatatgtata gagaaaaccc tttgttagag ggtttccaaa aagccaggca 300421 ggtatgtttg aaatgtgtct tcacgcagac tgacgtattt tgtccgcgaa tctttccggg 300481 ttgccgtcaa tcccgcttca cgcagcgttt taaaatgata agatgccgtg gttttgacaa 300541 tattgcactt ttcacctact tcaccgcagc tgagttcttt tccgctgaca taaagcgtac 300601 gaataatggc aagccttgat tcatcagaca gtgctttaaa aatttgcgct ctgatttgat 300661 catctgattg tttcatagtc atgaaactat aatacataat gggtgttgaa aaagcaactt 300721 atttttccag taaaggagca ggaagtcata agaggaagga ggaattcaat tccaataaaa 300781 gcgttttcaa ctaaaggtag gagaaaaatc acccgtaaaa tacaatcata taggaggatt 300841 acagagcatt tagaagcata aataagatca tgtggtcaca tggatgttta taaagaaatg 300901 gtacagaata aaagagaata tgctgtttgt gtgggaagtt acataaatgt tacggtaata 300961 aagattgctt aatatggagg gaaaatatga gtgtagatga gaaaccaatt aagataaaag 301021 tcgagaaagt ctctaagatt tttgggaaac aaacaaagaa ggcagttcaa atgcttgcca 301081 acggaaagac aaaaaaagag atcctgaaag caaccggatc aaccgttggg gttaatcagg 301141 cagattttga agtatatgat ggtgagatat ttgtcatcat gggtctatca gggagcggta 301201 aatcaacttt agtacggatg ttaaaccggc ttattgaacc gactgccgga aatatttaca 301261 ttgatggtga catgataaca aatatgtcaa aagaccagct ccgggaagtc cgccggaaaa 301321 aaatcagcat ggtcttccaa aagttcgctc tgtttccgca cagaacgata cttgaaaaca 301381 cagaatacgg actggagctt caaggtgtag acaaacaaga gcggcagcaa aaagcgcttg 301441 agtctcttaa gctcgttgga ctggaaggat ttgaacacca atatcccgac cagctttccg 301501 gcgggatgca gcagcgtgtc ggccttgccc gcgcgttgac gaatgacccg gacatccttc 301561 tgatggacga agcgttcagt gcgctcgatc cactgattcg taaagatatg caggatgagc 301621 ttcttgatct tcacgataat gtcggaaaaa caattatctt tattacgcat gacttggacg 301681 aagcgttgcg gatcggcgac agaattgtcc taatgaagga cggcaacatc gttcaaatcg 301741 gcacgcctga agaaatcctg atgaatccat ctaacgaata tgttgagaaa ttcgtcgaag 301801 atgttgattt gtctaaagtc ctcacagcag gccacattat gaaacgcgct gaaacagtgc 301861 ggattgataa agggcctcgc gtagcattga cactgatgaa aaaccttgga atttcttcaa 301921 tttatgcagt ggataaacaa aagaaattat taggtgttat ctatgcgtct gatgcgaaaa 301981 aagcggctga gtctgatttg tcacttcaag acatcttgaa tacagaattt acgactgtac 302041 cagagaatac gtatctgact gagatttttg acgttgtgtc cgatgcgaat attccaattg 302101 cggttgtgga tgagaagcaa agaatgaaag gaattgtcgt aagaggcgcg ctgattggcg 302161 cacttgccgg caataacgag tatatcaatg ctgaaggcac taacgaacaa acacaagatc 302221 cttctgcaca ggaggtgaaa taagatggat agactgccta gaataccttt agcagatatt 302281 attgaccgtt ttgttgactg gattacgatg acgtttggcg gattcttcga cggaatcgct 302341 aacggattgg ccgcttttgt aaatggaatt gtcaccggtc ttggatttat tccatctatt 302401 ttgttaacga ttattttcgc cgcacttgcg tggtggatca gtacaagggg aattgcgtta 302461 tttacgttga ttggattcct cctgatcgat tatttaggat attgggaccc aatgctgcaa 302521 acattggcgc ttgttttgac atctgtgatt atttcgattg tggtcggggt tccgatcgga 302581 atttgggcgt ctcagaaaga aacggttcgc cgtattgtaa cgccaattct tgatttaatg 302641 cagacaatgc ctgctttcgt atatctattg ccggcgattt tcttctttaa catcggtgtt 302701 gtgccgggtg ttgttgcatc tgttatcttc gcgatgccgc cgacaatccg catgactgtt 302761 ctcggtatta aacaagtgcc ggcggatttg attgaagcga ctgaggcatt cggttctaca 302821 acagctcagc gtttgtttaa agttcagctc ccgcttgcga caaaaacgat tttggccggg 302881 atcaaccaga gcatcatgct tgcgttatca atggttgtta tcgccgcaat ggtcggtgca 302941 ccgggacttg gttctgaagt atacagtgcc gttacacagc tgaaaaccgg ggtcggagta 303001 gaggccggta tcgccatcgt tatcgttgcc attaccctgg accgtattac tcaaaatatt 303061 aaagtgaaga agaaaagcag ggggaatgcc tgatgcttaa aaaaatcata ggcatcggcg 303121 tttccgccat gctggcgctc tcacttgcgg cttgcggttc agaaaacgat gaaaatgcat 303181 ccgcagcaga acaagtgaat aagaccatca tcgggattga ccccggttca gggattatgt 303241 ccctgactga caaagcgatg aaggattatg acctgaatga ctggacattg atttcagcgt 303301 caagtgctgc gatgaccgct acgcttaaaa agtcatacga ccgtaagaaa ccgattatca 303361 ttacaggatg gacaccgcac tggatgttct ccagatataa gctgaaatat ctcgatgatc 303421 cgaaacaatc ttatggcagc gcagaggaaa tccatacgat cacacgcaaa ggcttcagca 303481 aagagcagcc gaatgccgca aagcttctga gccagtttaa atggacgcag gacgaaatgg 303541 gcgaaatcat gatcaaggtg gaagaaggcg agaaacctgc caaagttgct gctgagtacg 303601 tcaataaaca caaggatcag attgccgaat ggacaaaagg cgttcaaaag gtgaagggag 303661 acaaaatcaa ccttgcctat gtggcgtggg acagtgagat tgcaagtaca aacgtcatag 303721 gcaaagtctt agaagacttg ggctatgagg taacacttac tcaggtagag gctgggccga 303781 tgtggactgc aattgcgacg ggaagtgcgg atgcatccct ttccgcatgg ctgccgaata 303841 cccataaagc atacgccgct aaatataaag gcaaatatga tgatattggc accagtatga 303901 ctggtgtgaa gatggggctt gttgttcctc aatatatgaa aaatgtcaac tcaattgaag 303961 atttgaagaa gtaatcaaaa aagcagcctg tgtcaggctg ctttttttgc gttaagaagc 304021 gttagcggca gcaagtgatt ccgccttctg aaatgttttg agcacggcgt tcgccaaaat 304081 atgaatgccg gtaaacatcg catttctgtc aaaggtcatg tgcggatgat ggagccccgg 304141 ctggagcccg cagcctagtc cgagcatcgt tgttttcaga ttcggcacct tcacggcgta 304201 aaaatggaaa tcctcgccgc cggtggtgac aagcgggtca tcaagccgct cagccccgat 304261 gatttccgta atggcttctg ccatgatcgc ttcagcttct ttattttgtg ttgccgcagg 304321 aaggctgtgt tctttgtgca gctcgatctt tgcgccaaat gcagcggcgg ccgcttcaca 304381 ggctctttct gtttcggcga ttaatgcctc catggcttca ttggtctgtg cgcgcaaatc 304441 aaggctgaac gatgcttttc ctggaatgat gttagagctt tcaccgccgg cttgcagttt 304501 tgtcattttg acggtatgcg ggatttgcgg gtcaatatga atgagtccga gcttgtgtac 304561 aagaaatgcc gcaatttcaa tgctgttttt cccgaggtgc ggacgggcgc catgagcctc 304621 ttccccgatg atcgttccct caatgtgctg gcttgatccg tgcagaatag aaggagcgca 304681 gcggccgttc tgtgtttcct ggatcggacg gacgtgaacg ccatacaaat agtcgatatc 304741 atcaagcacg ccttcttcta tcattttcaa ggcgccgccg cctttttctt ctgccggctg 304801 aaagataaaa cggattgtgc ccttcggaag ctcaggttgt ttttttagca gcattaacgt 304861 gcccaatgcc attgtcatat gtgaatcgtg tccgcaggaa tggttggcgc gaaatgtgcc 304921 gttaacctcc tgccacagcg cgtcaatatc agcgcgtacc gctacaacag gtgagcctga 304981 gccgatttcg ccgacaaccc cggtgcagtc tgaaaacgtg cgcgtccggc accctaaatc 305041 ctcaagcttt tgtttcaaaa atgaagttgt ctcatattcc ttccagctga cttcagggtt 305101 cgcgtgcaga tgctcgaaga tgtccataat ggtttgtttc atttcttctg aaagcttttg 305161 catggtaaga aatacctcct tctatcagaa tgaattttta ccttctttac tttatttata 305221 ttgaaacagg aagataggct gtatataata tagcacatat tgctactatt cagaataatt 305281 aatattttca aacagagggg atggatcgaa atatgagtat gccagcagcc gaaacacagc 305341 ctaagaaaaa acgtatgaca tttaaaatgc ctgacgccta tgtcctctta tttatgattg 305401 ctttcatttg cgcaatcgct tcatatattg tgccggcagg tgaatttgac cgcgtgacaa 305461 agggggatgt cacgaccgct gttccgggaa gctatcattc aattgaacag tctccggtca 305521 gattgatcag cttttttact tctctacagg atggaatggt tggatcagca cccatcatct 305581 ttctgatttt attcacaggc ggcaccattg ctattctaga aaaaacgggt gccatcaatg 305641 gcctgattta caatgtcatc agcaaattcc gcacaaagca attattattt atttgtattg 305701 tcggcgcatt gttctccatt ctcggaacaa ccgggattgt cgtgaattca gttatcggtt 305761 ttatccccat cggcctcatt gtggcacgat ccttaaaatg ggacgcagtc gcgggagccg 305821 ctgttatata catcggctgc tacgctggat ttaactccac catattatca ccgtcaccgc 305881 tcggtttatc acaatcaatc gcggagctcc ctcttttctc aggaatcggc ctgcgagttg 305941 tgatatacat atgctttttg ctgtcttcta ttatttatat ctatttgtat acgagaaaat 306001 taaaaaaatc aaaagatgcc agtgtgttag gaacagattg gttccctgcg gcaggaatgg 306061 gcgaagccgg taaagaagaa gatcagtcag tgccgtttac cgttcgccat aagctgattt 306121 tggctgtggc gggactctca cttgtcggat ttttatacgg cgctttgaag cttggctggt 306181 cagattccca aatggctgcg acatttattt ttatttctgt ccttgccggt ttaataggcg 306241 ggcttgcggc gaacgatatt gccaaaacct tcattacggg ctgccaaagt cttgtatacg 306301 gggcgctgat tgtcgggatg gcacgaagca tttccgttat ccttgaaaat ggaaagcttc 306361 tcgatactgt cgtcaatgct ttggcttcac ttttggatgg attcagcccg attgctgggg 306421 caatcggcat gtatatcgcc agtgcgctgc ttcattttct catctcttca ggttctggcg 306481 aagccgttgt atttattcca atcctggcgc cgctcgctga tttgatggga atcacgagac 306541 aggttgcggt tgaagcggtt atgcttggag aaggggtcgt caactgtgtg aacccgacat 306601 ccggcgttct catggcggtg cttgccgcca gcggtattcc gtatgtcaag tggctgcggt 306661 ttatggtgcc gcttgctctg atttggttct tgatcgggct tgtctttatc gtgatcggag 306721 tcatgatcaa ttgggggccg ttttaacgat tgctgcccgc cggcttgtac ggcgggcttt 306781 tgagttattc attgcagaag cgcaggctgt tattgtaaca tgtaagccat aagccattcg 306841 taaaagtgcg ggaggaaggt catgaataat ctgcgtaata gactttcagg cgtgaatggg 306901 aaaaataaga gagtaaaaga aaaagaacaa aaaatctggt cggagattgg gatgatagcg 306961 ggagcatttg cgctgcttga tgtgatcatc cgcggcatta tgtttgaatt tccgtttaaa 307021 gaatgggctg caagccttgt gtttttgttc atcattatct tatattactg catcagggct 307081 gcggcatccg gaatgctcat gccgagaata gacaccaaag aagaactgca aaaacgggtg 307141 aagcagcagc gaatagaatc aattgcggtc gcctttgcgg tagtggtgct tacgatgtac 307201 gacaggggga ttccccatac attcttcgct tggctgaaaa tgattcttct ttttatcgtc 307261 tgcggcggcg ttctgtttct gcttcggtat gtgattgtga agctggctta cagaagagcg 307321 gtaaaagaag aaataaaaaa gaaatcatct tttttgtttg gaaagcgagg gaagcgttca 307381 cagtttcggg cagctttttt tataggaaca ttgatttgta ttcactctgc caagttgttt 307441 tgatagagtg attgtgataa ttttaaatgt aagcgttaac aaaattctcc agtcttcaca 307501 tcggtttgaa aggaggaagc ggaagaatga agtaagaggg atttttgact ccgaagtaag 307561 tcttcaaaaa atcaaataag gagtgtcaag aatgtttgca aaacgattca aaacctcttt 307621 actgccgtta ttcgctggat ttttattgct gtttcatttg gttctggcag gaccggcggc 307681 tgcgagtgct gaaacggcga acaaatcgaa tgagcttaca gcaccgtcga tcaaaagcgg 307741 aaccattctt catgcatgga attggtcgtt caatacgtta aaacacaata tgaaggatat 307801 tcatgatgca ggatatacag ccattcagac atctccgatt aaccaagtaa aggaagggaa 307861 tcaaggagat aaaagcatgt cgaactggta ctggctgtat cagccgacat cgtatcaaat 307921 tggcaaccgt tacttaggta ctgaacaaga atttaaagaa atgtgtgcag ccgctgaaga 307981 atatggcata aaggtcattg ttgacgcggt catcaatcat accaccagtg attatgccgc 308041 gatttccaat gaggttaaga gtattccaaa ctggacacat ggaaacacac aaattaaaaa 308101 ctggtctgat cgatgggatg tcacgcagaa ttcattgctc gggctgtatg actggaatac 308161 acaaaataca caagtacagt cctatctgaa acggttctta gacagggcat tgaatgacgg 308221 ggcagacggt tttcgatttg atgccgccaa acatatagag cttccagatg atggcagtta 308281 cggcagtcaa ttttggccga atatcacaaa tacatctgca gagttccaat acggagaaat 308341 cctgcaggat agtgcctcca gagatgctgc atatgcgaat tatatggatg tgacagcgtc 308401 taactatggg cattccataa ggtccgcttt aaagaatcgt aatctgggcg tgtcgaatat 308461 ctcccactat gcatctgatg tgtctgcgga caagctagtg acatgggtag agtcgcatga 308521 tacgtatgcc aatgatgatg aagagtcgac atggatgagc gatgatgata tccgtttagg 308581 ctgggcggtg atagcttctc gttcaggcag tacgcctctt ttcttttcca gacctgaggg 308641 aggcggaaat ggtgtgaggt tcccggggaa aagccaaata ggcgatcgcg ggagtgcttt 308701 atttgaagat caggctatca ctgcggtcaa tagatttcac aatgtgatgg ctggacagcc 308761 tgaggaactc tcgaacccga atggaaacaa ccagatattt atgaatcagc gcggctcaca 308821 tggcgttgtg ctggcaaatg caggttcatc ctctgtctct atcaatacgg caacaaaatt 308881 gcctgatggc aggtatgaca ataaagctgg agcgggttca tttcaagtga acgatggtaa 308941 actgacaggc acgatcaatg ccaggtctgt agctgtgctt tatcctgatg atattgcaaa 309001 agcgcctcat gttttccttg agaattacaa aacaggtgta acacattctt tcaatgatca 309061 actgacgatt accttgcgtg cagatgcgaa tacaacaaaa gccgtttatc aaatcaataa 309121 tggaccagag acggcgttta aggatggaga tcaattcaca atcggaaaag gagatccatt 309181 tggcaaaaca tacaccatca tgttaaaagg aacgaacagt gatggtgtaa cgaggaccga 309241 gaaatacagt tttgttaaaa gagatccagc gtcggccaaa accatcggct atcaaaatcc 309301 gaatcattgg agccaggtaa atgcttatat ctataaacat gatgggagcc gagtaattga 309361 attgaccgga tcttggcctg gaaaaccaat gactaaaaat gcagacggaa tttacacgct 309421 gacgctgcct gcggacacgg atacaaccaa cgcaaaagtg atttttaata atggcagcgc 309481 ccaagtgccc ggtcagaatc agcctggctt tgattacgtg ctaaatggtt tatataatga 309541 ctcgggctta agcggttctc ttccccattg agggcaaggc tagacgggac ttaccgaaag 309601 aaaccatcaa tgatggtttc ttttttgttc ataaatcaga caaaactttt ctcttgcaaa 309661 agtttgtgaa gtgttgcaca atataaatgt gaaatacttc acaaacaaaa agacatcaaa 309721 gagaaacata ccctggaagg atgattaatg atgaacaaac atgtaaataa agtagcttta 309781 atcggagcgg gttttgttgg aagcagttat gcatttgcgt taattaacca aggaatcaca 309841 gatgagcttg tggtcattga tgtaaataaa gaaaaagcaa tgggcgatgt gatggattta 309901 aaccacggaa aggcgtttgc gccacaaccg gtcaaaacat cttacggaac atatgaagac 309961 tgcaaggatg ctgatattgt ctgcatttgc gccggagcaa accaaaaacc tggtgagaca 310021 cgccttgaat tagtagaaaa gaacttgaag attttcaaag gcatcgttag tgaagtcatg 310081 gcgagcggat ttgacggcat tttcttagtc gcgacaaatc cggttgatat cctgacttac 310141 gcaacatgga aattcagcgg cctgccaaaa gagcgggtga ttggaagcgg cacaacactt 310201 gattctgcga gattccgttt catgctgagc gaatactttg gcgcagcgcc tcaaaacgta 310261 cacgcgcata ttatcggaga gcacggcgac acagagcttc ctgtttggag ccacgcgaat 310321 gtcggcggtg tgccggtcag tgaactcgtt gagaaaaacg atgcgtacaa acaagaggag 310381 ctggaccaaa ttgtagatga tgtgaaaaac gcagcttacc atatcattga gaaaaaaggc 310441 gcgacttatt atggggttgc gatgagtctt gctcgcatta caaaagccat tcttcataat 310501 gaaaacagca tattaactgt cagcacatat ttggacgggc aatacggtgc agatgacgtg 310561 tacatcggtg tgccggctgt cgtgaatcgc ggagggatcg caggtatcac tgagctgaac 310621 ttaaatgaga aagaaaaaga acagttcctt cacagcgccg gcgtccttaa aaacatttta 310681 aaacctcatt ttgcagaaca aaaagtcaac taaccgcaac tttagagtaa agggctgatt 310741 gtcaatgtgg gagcagttgt atgatccgtt tggaaacgag tatgtgagcg cacttgtggc 310801 gctcactccg attctctttt ttcttttggc tttaactgtt ttgaaaatga aaggcattct 310861 tgcggcattt cttaccctag ccgtcagttt cttcgtctcc gtttgggcat ttcatatgcc 310921 ggttgaaaaa gcgatttctt ctgttttgtt aggaatcggg agcgggctgt ggcccattgg 310981 ctacatcgtc ctgatggcgg tgtggctgta taaaatcgcc gtgaaaaccg ggaaatttac 311041 cattattcgg tccagcattg ccggcatttc gcctgaccaa cgattacagc tattattaat 311101 tggtttttgt tttaacgcgt ttttagaagg cgcggccggt tttggtgttc cgattgcgat 311161 tagtgcggcg ctgctcgtcg aacttggttt taaaccgtta aaagcggcgg cgctctgctt 311221 gattgcaaac gctgcctccg gagcctttgg ggcgattggg attcctgtca tcacaggggc 311281 gcagattggt gatttgtctg ctcttgagct gtctcggaca ttaatgtgga cactgccgat 311341 gatctcattt ttaataccat tcctgcttgt attcttatta gaccgaatga aaggaatcaa 311401 acagacatgg cccgctcttc tggttgtgag cggtgggtat acagcggttc agacactgac 311461 aatggcggtg ctcgggccgg aattagcaaa cattttggcg gccttattca gcatgggcgg 311521 gcttgccctc ttcctccgca aatggcagcc gaaagagatt taccgcgagg aaggggccgg 311581 cgatgctggt gagaaaaagg cataccgtgc cgctgacatt gcgaaagcgt ggtctccttt 311641 ctacatttta actgcggcga tcaccatctg gagccttcct gccttcaaag cgcttttcca 311701 agaaggcggg ctgttatatc aatcaacgct cctgttcaaa atgccttttc tgcatcagca 311761 aattatgaaa atgccgccga ttgcgccatc tgccatgccg ttagatgcag tctttaaagt 311821 tgatctgctg tcagcgactg gtacagcgat tttagcggcg gtcatcgtga cagggctgtt 311881 cagcaaaaag ttctcctctc gggatgcctt tgcttccttg aaggagacgg gaaaagagct 311941 gtgggtgccg attatgacga tctgcttcgt gatggggttt gccaatctgg ccaacttcgc 312001 agggctcagc tcttcaattg ggttagcatt ggcgaaaaca ggagacctgt tcccgtttgt 312061 cagtcctgtt ctcggctgga ttggcgtgtt catcaccggt tctgttgtca gcaataatgc 312121 tttgttcggc catttgcagg ttgtcacggg agcgcagatc ggtgcgggtt cagatttgct 312181 gttagccgca aatacggcgg gcggtgtcat ggcgaaactt gtttctcctc aatctatcgc 312241 catcgctgcc gcagcggtcg gccaaacagg caaggaatct aaactgttta aaaggacagt 312301 ggcgtacagc ctgattctgt tattgatcat ttgtatatgg acgtttattc ttgcaagatt 312361 aggagtgtaa tagaaaaaag cagtacatgc ccagcatgta ctgctttttt tatgttaatt 312421 tgctttcttt gtcatttcgg ctgttgtttt cactctggct tttcccataa ataaaatggt 312481 aaccgccgcg aggacaattg gaatcaaagc gagcaaaaag acatacgtga tacttgatga 312541 catcgcgtca ataatgcgat tcaggatcgc atcaggaatc tgggaacgtg ttcccgcttg 312601 gaatatctcc tgcgggtcgc caatattttg cgcagcgcct gatcccgctg agcctttcat 312661 accgctgaag gcgtcattca gcttgtttgt gaatacgttt gtttgcaccg ttccgaaaat 312721 ggtgacacct aaggtcatgc caaatgatcg caaaaatgaa tttgtagagt ttgccgttcc 312781 ccgaaagcga ggttcaagat cattcatcga tgccgccggc agcagggaga agttaaagcc 312841 tacaccaaag cctgaaatca tcataaagac tgtcagccat acccgtgctg tgtcaggcgt 312901 catattggaa agaagcagca tgccgataaa gaaagctata acagatatca gcatcaaatt 312961 gcggaagctt gccttcgttt ggaagatccc gccgatcatg cttccgatga ctgatccaat 313021 catcatcggc gtcagaatga agcccgcgct tgtcgccgag ctgccgtaga ccgcctgaac 313081 gaaaatcgga ataaataccg ctaaaataat aaatgttccg ccatacagga aagcgagaat 313141 ctgtgctgtg gcaaacaagc ggttcttaaa catccagaaa gaaataatcg gctcttctgc 313201 ttttctctcc acaataaaaa aggcaatgaa gaaaacggcg aatacaataa acagcccgat 313261 gatctgaatg gagttccaat cgtatgtttt gccgccaagc tcaagggcga acatcaggca 313321 tacaatggat acgactaagg taatcgcgcc gccccagtct attttctgct ttctgtgctc 313381 cagagattct ttgtagtagc gaataatgaa aaacaatgac aatgcgccga tcggcacatt 313441 gatgtaaaac acccagtgcc agctgatcga atctgtaatg atcgcgccta agagcggacc 313501 aagaacactg gataatccaa atacagcacc gaacatgccg gacatttttc cgcgtttttc 313561 cggcggaaac aaatcaaaga taatggtaaa ggcaatcggc aggagcgcgc cgcctccgat 313621 cccttgaatg gcccggaaga tgatcagctg attcatcgtc tgggcaatcc cgcataaagc 313681 agaaccgatt aagaaaaaaa taagtccaaa caggaaaaaa cgttttcggc cgtacatatc 313741 ggaaagcttg ccgtaaatcg gcatgccagc cataaccgcc accatatagg atgccgtcac 313801 ccaggcaaat ttatcgaagc ttccaagatc ggctacgata ttgcccatcg cggtggcaac 313861 aatcgtattg tccattgcag acatcaagat gcccagcagg agaccgagga ccacaaattt 313921 ggtggaagcc tgttttgctg ttgttgtgtc catttgttct acctcctctt acttttctat 313981 gtaagttctg atatcatgat aatagtttga ttgttgaata tctcgattat caagataaac 314041 tcgattttat agggaggact gtcagttgtc aacaagaaat tccagaagtg agttggaaaa 314101 gactgctgtt cagctttttc gaaaactggg cacaagaacg gttctgtttc atcaggcagc 314161 cgctcaagct ctcggtctgt ttcccaccga tttgaaatca gctgacattt taaatgaagc 314221 agggccgatg acggccggag agctggggaa aaaaaccggc ctcagcacgg gttccgtcac 314281 ggcgcttgtt gaccggctgg aaaaagcggg gtatgtggct cgtgaaaagg acccgaacga 314341 tcgcaggaga gtcgtaatcg tccctttgac tgcttcgaaa aaacatataa aggatttgtt 314401 ccgtcctctg tctgagtcaa cgatggattt gtgccgcgaa tatacggaag aggagctgga 314461 actcattttc agttttgtag gcaaagctgc cgatattatg gaggaagagc ttgaacgtct 314521 gaaacagtaa gtgaatttgt gcatagcttg gcccgttccc gaataaattg tacaagttac 314581 ataagagaag ggagtacggg ccggtgaaca tttttttgag ctatattgtg ctgggactgt 314641 ccttgtctgc gcctgtgggg ccagtgaatg cggcgcaaat agacaaagga attaaaaacg 314701 gtttttggca tgcatggatt ttcggtttag gcgccatgac agcggatggg ctgtacatgc 314761 tttttatcta tttcgggctg tcgcagttct tgaccgctcc atttgtgaaa acgtttttgt 314821 ggctgttcgg cttttttgtc ctgacctata ccggaattga aacgctgaaa aacgtcagag 314881 aaccgatgga tgtgcgaagc tcgcggggga aaccgtcata caggaaaaca ttcgcatcgg 314941 gttttctcat ttcattgtca aacccattga gcatcctttt ttggcttgga atttacggaa 315001 gcattcttgc gaaaacagca gaggcctaca atatgaatca gcttctaatc tatagctccg 315061 gcatcatgat cggcatttta atctgggatt tctgcatggc tatcacagcc agtacgttca 315121 gaaacctgct tcatgaaaag ctattgagag gattgaccgg aatcgccggt gtatccctcc 315181 ttgtgtttgg cttttacttt ggttatcagg gcatcaaaca gttattgggc tgattcatga 315241 aggacagtca cctgccgctt ccagttttaa tatagtatcc agatgatact ggaggtggat 315301 caatggtgaa tgggatttac accaaaagtt ttctggaacg tattcaggaa gagcttcctg 315361 aatggcaaag aatcgctttt gagctgctgg cagaaactct gggggacgac gcggatacat 315421 ttccgtgcat tcccggacgc caggcgtttc tgactgatca gcttcggatt gcttttgccg 315481 gagatccgcg ggaaaaccgc acagcggagg aactggctcc gttgcttgcg gagtacggca 315541 agatatcgcg ggacacggga aaatacgcat ccctcgttgt gttgtttgat acaccggaag 315601 atttggcgga gcattattcg attgaagcgt atgaagagct gttttggcgc tttttaaata 315661 gactgagtca tcaagacgaa aaagaatggc cggaagacat tccggccgat cctgagcatt 315721 ataaatggga gttttgtttt gacggcgagc cgtatttcat tctgtgcgct acaccggggc 315781 acgaggcaag aagaagccgg agctttcctt tttttatggt cacgtttcag ccaaggtggg 315841 tgtttgatga cctaaatgga tcaactgcat ttggccgtaa catgagcagg ctgatccgat 315901 ctcgtttaga ggcctatgat caggctccga ttcacccgca attaggctgg tacggaggaa 315961 aagataatcg tgaatggaag cagtatttcc tccgtgatga cgaaaaacag gtatcgaagt 316021 gcccgttttc ttatttaaag aacatgttca acaaaatgaa ataaatcaag gactggcagg 316081 gcgatcttta tgaccctgct ttttttgata gatcatggta acgatggcga taatcacgag 316141 aaaacctatg ctgacgaaaa aaccgggccg gcttgatttt tcaaacaatg taccggacac 316201 agctgcagca atcagaacca tcgctaaata aatttgcgtt tttcccatgc cctcgggatc 316261 agtcagcttt ttgctggaga acaggataaa cagccaagtg tataaaagca taagccccgc 316321 agctgttgtc atatgctcat aaatgttttt aggcagcact aacgacaaaa taatggagag 316381 gacaagcccc gcaaacgtca gcccaagtgc cggccagcat atttttttgc cttcctttag 316441 agtaaagcat ttcggcgcgt cgccgtcatc agccattgta caaagcaatg tcgtaaccgc 316501 aaatagcgaa gcgacaaggg tcgagaaccc tgcgatgatg aaaatcccgt taaatatatc 316561 aaggatgatc tcaaggttat atccttttaa tgacgtaatg aacggactgt cctgttcagt 316621 aaacgtgtgt aacggaacca aaagcagagc aagcccgatt gaaatgatat aaataatcgc 316681 cagcgtcgcc agcatcagtt tccctgattt agacgcttcc tcaggttttt ttaagtgaac 316741 cgccatcagc cccatgacct caattccgcc aaaagcgtaa aacgcgtaga ttaaacctgt 316801 ccacagcccc atggcgccgt atgggaaaaa ctcactcgtc ttatttggaa catgtatgcc 316861 atgatttccg ccggacagga taccgcataa agccaggatg gcaatgacaa taaacataaa 316921 aatagcagct gttttaatga ctgccagcac gttttctgtt ttttcaaaga cggacaggcc 316981 ggtgaaaata ataaggagcc caagtactgc gtagattgag gcaaacaccc atagcggcac 317041 ttgaggaaac caatgcttcg taaagagcga aatggctgtc agctggcttc cggtaatcag 317101 catttctgat gtccagtaca cccagccgtt gctgaagcct gcccatttgc cgaatgcttt 317161 tcgggcatac gcacaaaacg agcccttttc cggctgcttc gccgatagct tggcgagctg 317221 ttcaaagaca aaatacgtac cgatccctgc gatcagaaat gaaaggagaa cggaaaaacc 317281 gctttttaca attgcgatgc tggaaccgag aaagaagcct gttccaatcg tgcagccgac 317341 tccgatcagt gacagctgcc accaagccag attccctttt ggctggtctt tttttgtttg 317401 gctcattatt tattcaaccc cttttatcta aggttagatt gtgatctgtc caaagcttat 317461 atacatcgga tttttgcctc tttttacatg gagaaggaag cagacgctca tactaatgaa 317521 aaaaggagca aaccaatgac acagcaatat attgtggagc cgaaaaaagg gcttgggctg 317581 aagctgaaaa aggggcagat tttaaaggtg gttgatgtag aagggcagca ggtggctgat 317641 tttgtcgcat accatgccaa ggatttttat gaacaccttg atcagggagc gacgatagac 317701 gccaatcact ccattcatgt gaaggtcaac gaccatctct actccaacct gtataagccg 317761 atgttaaccc tgattgaaga tacggtcggc aagcatgatc tgctgttgcc cgcctgccgt 317821 cctgatatga acaggctctt atatgggaag caaaaggatg agtttcagga tacgtgctat 317881 gacaatatga accgtgcgct tgagcagttt ggcgtaccga agccccacat gcattaccca 317941 tttgcgattt ttatgaatac tgtccttgat gagaaaggga atctgtctgt ggaaacgccg 318001 ctttcgaatg ccggagatta tgtaaggctc agggcggaga tggatttaat tgtcgcgttt 318061 tcttcctgcc cgattgaaaa agggaaatgc aatggcgaca gtgtgacatc catacgggtt 318121 gaagtcagct gatctctctt gttcacagtg aatgaagacc tgtgctatat ttaataggga 318181 tacataacag tcatgattca ttttcattga tttagggaaa tgatcagtaa taagggaaaa 318241 tgtacaggag gaatgattgg gatgagcatg caggaaaaga ttatgcgtga gttacatgtg 318301 aagccctcaa ttgatccaaa gcaagaaatt gaggaccgag tcaatttttt aaaacaatat 318361 gtaaagaaaa ccggtgctaa aggctttgta ttgggaatca gcgggggcca ggattcaaca 318421 cttgcgggaa gactcgctca gcttgcggtg gagagcattc gcgaggaggg cggagacgct 318481 caatttatcg cggtccgtct tccgcatggc acacagcagg atgaagacga tgcccagctt 318541 gctttgaagt ttattaagcc ggataaatca tggaagtttg atattaaatc gacagtcagc 318601 gctttttctg atcagtatca gcaggaaaca ggcgatcagc tgacggactt taataaagga 318661 aacgtaaaag caagaacaag aatgatcgcg caatacgcga tcggcggcca ggaaggtctt 318721 cttgtgttag gaacagacca tgctgctgaa gcagtgactg gtttctttac gaagtacggt 318781 gacggcggag cagacctcct gccgctgaca ggcttgacga agcgccaggg aagaaccttg 318841 ctgaaagagc tgggtgcacc ggaacgctta tacttaaaag aaccgactgc cgatctgctc 318901 gacgaaaaac cgcagcagtc ggatgaaaca gagcttggca tttcctacga cgagattgac 318961 gattatctcg aaggaaaaga agtatcagcg aaagtatcag aagcgctgga aaaacgctac 319021 agcatgactg aacataaacg ccaggttccg gcgtctatgt ttgatgactg gtggaaataa 319081 gttgaagaaa gcccgctctc ggagcgggct tttgtcgtgt acagaagctt tatttgatgc 319141 ggatatgatt cagctttacc attaatctgt cggcgaacct tcggaggctg cctcttgtat 319201 caggatctaa tgggagttcg gctctcgcgg caatgttctc tgccacatcc tgaatcgaca 319261 ggttgtctgt ttgaatgtgg tcctcaaaaa tgggtgatga taatccttca acacagcggt 319321 caatttgttt ggcggcccat gagttttttc cttctgctct ggtgcgcagc ctttttaaca 319381 aggtttcctt tgaagccatt agtgtaaagt ggtgaacgat cctgccttcc tgtctgagcc 319441 tgccgatgat ctcattgaag tattcagggt gtacaatcgt cataggcaca ataaggatgc 319501 cgcggtatgt atctgtcaga gaagctagca aactgtaatt gaacgcccgc cataaaggat 319561 agctttgaaa atcgtccttt gcgatctcct gcggcaccat ggagcgcagc gcaaaaccca 319621 ttttctcggg atcatacacg taagatgggt tcagccttct gtgcagttcg aaggctgttt 319681 gtgtttttcc cgaaccgaat gccccgttta tccaaatgat catcgccatt tctcccttcc 319741 tatttatcat acagaaaaag acccttccat cgaagagtca gctggaaaaa caataaaggc 319801 ggaaggtttt aacgcttttt tgcgtcgaag tattaaaata cctgcagaaa tgttgtacaa 319861 tgaatgtcat tcaggcaaaa atggctacaa caaagcgcac tataagcttg accggtaaag 319921 ccggtatcta tataaatatt cgctaaataa gcatataatg aatatataat ttcattcctt 319981 aggaggattt cgccgaagat gaacgctaaa cgagccatcc cagtaagaga aagaaatatc 320041 gtcctgatcg gattcatggg tgtaggaaaa acaacaatcg gccaattggt cgctaaaaaa 320101 ttatatagag attttattga tattgaccag cagatcgaaa aggatttcaa tatgtcaatt 320161 cctgagatat ttgagaaaaa gggagaagac tttttccgga aaacggagaa ggaatatatt 320221 ttagacatct gccatcataa acgattcaaa atcgtatctc tgggcggggg atcttttaaa 320281 caagaagaaa tcagaaattg ctgtctggaa aactgtctcg tgcttcatct ggacctgtca 320341 tgggagaact ggaagcagcg cgcggattta ttgatcgaaa gccgccctgt actgcataac 320401 cgttcaatgg atgaaatgga acagctgttt aacgaaagaa aagtcattta tgacaagcac 320461 aattcaaaag tggcaacaga caacctttcc ccggaagagg ttgccgatta cattgttgag 320521 acattaaaaa ttggctggga tctttatcag ccgatgtaaa aagccgtgcg cagcgcacgg 320581 ctttttttat cgttttatcc cttgtatcaa aatcgctttt aaacaaaagg agatgggctg 320641 tccgttttgg ttcaatgtaa tacagaacgt gtcgcgtgct tcgtctgatg cgtgattcaa 320701 gtgggtaatg atttgttttt ctcggtcagc gggggttccg cctcgtttga tccagctatc 320761 gtattgaatc ggcaagttcc acttttggat gtcttgatag gccagttgat tggcgctgaa 320821 catcgcctgc cattctgata atgagctttc acgaacatgg gaagggtctc gaagccggtt 320881 caaatgattg acaaactcat caagaacggg atcttcaggc gcgtaatgat caactaagag 320941 aaaacgtccg tcctgtttta gtacgcgtgc aacctctctg acagctttgc ggacatctga 321001 aaaatggtgg gctgcgtatc ggcaggtgat gatgtcaaat gaatcgtcgg ggaaggggag 321061 tgactctgcc gttccttgct gaaagcgtac gttttcaact cctttttctt gcgcgaagga 321121 ggacgcaacc tcaaccatct ctttcgttgc atcaacaccg atgcactcct gtacataagg 321181 agaaaatgcc agcgccgtat ggccggcgcc cgctcctata tccagcactc gatgctctgc 321241 ccggcattcc gctgttttga tcatcaaccc caaatcttcc ccctcggcaa ataccttttc 321301 atcccgatac atctcggcgt ttttagaaaa cggtgtttca tttgtcattt gaaccagctc 321361 cttcttttcg taaatgatga tatggattat gttagcaatt tctgttatga ttcgtccaag 321421 atataaaaat gatgaaaatg ataggttcaa cctatggagg ctgaaatgga tattaaagtg 321481 atggaatatg cagcggaaat tgcccggcgc caaagcttta caaaggcggc ggaacatctt 321541 catatcgcac agccgtctct cagccagcaa atcaaaaagc ttgaggctga gctggggctt 321601 accctttttc acagatccca tggctctgtt acactgacac ctcacggcag gcgtttcatt 321661 gaaaaagccg aggacatcat tcgttccaga gatgatttgc ttcgggaaat gcaggagcga 321721 tcacagggaa tcggtcataa attatccatc gggattcctg ctgtaacagg gagatatctc 321781 tttcctccgc tgctgaagca gtttttggcg cgctatcctc atgtggaggt tcagcttgtt 321841 gaaaaagatc cggtttcatt agagaagatg acggcaaagg gagaagttga cctttctgtt 321901 ttatccttgc ccatcgagga tgaacggctc tccattacac ccttgctcac ggaaccggtt 321961 gttctcgcgg tgccgaagga aaaacaaagg tggatgccgc cggaattggt cgcgctgatt 322021 gagaaagcgc tggaagaaga tgagggacgc cagccgtgtg tgccgattga catggtaagg 322081 aacgtgccct ttattctgtt aaaagaaggc ttcggctttc gcaggacagt tctcgatctc 322141 tgtgcggaaa gcggctttaa gccgaatgct gcctttaaga cgagccatat tgaaaccgcc 322201 caatctcttg tggctaacgg attaggtgtg acaatggcac cgaatatggt cagaagggat 322261 aaagatccgg gtgtgatcta tttatcgatt caatccgcgc catcacgaac cctcgtcttt 322321 gtctttttaa agaaccgcta tgtcagtctg acggcccagg cctttatgga actaagccgg 322381 gaaagtctta aacaaacgtt tgatgaaggc tgtctgggaa acaaagatga aaatatttag 322441 aaaacaaaga cgaaacgtgg tagtatagga atacaaacta aatcttataa aacaaagggg 322501 aataatcgga aatgcaacta ttcgatctgc cgctcgacca attgcaaaca tataagcctg 322561 aaaaaacagc accgaaagat ttttctgagt tttggaaatt gtctttggag gaacttgcaa 322621 aagtccaagc agaacctgat ttacagccgg ttgactatcc tgctgacgga gtaaaagtgt 322681 accgtctcac atataaaagc ttcggaaacg cccgcattac cggatggtac gcggtgcctg 322741 acaaggaagg cccgcatccg gcgatcgtga aatatcatgg ctacaatgca agctatgatg 322801 gtgagattca tgaaatggta aactgggcac tccatggcta cgccacattc ggcatgcttg 322861 tccgcggcca gcagagcagc gaggatacga gtatttcacc gcacggtcac gctttgggct 322921 ggatgacgaa aggaattctt gataaagata catactatta ccgcggtgtt tatttggacg 322981 ccgtccgcgc gcttgaggtc atcagcagct tcgacgaggt tgacgaaaca aggatcggtg 323041 tgacaggagg aagccaaggc ggaggtttaa ccattgccgc agcagcgctg tcagacattc 323101 caaaagccgc ggttgccgat tatccttatt taagcaactt cgaacgggcc attgatgtgg 323161 cgcttgaaca gccgtacctt gaaatcaatt ccttcttcag aagaaatggc agcccggaaa 323221 cagaagtgca ggcgatgaag acactttcat atttcgatat tatgaatctc gctgaccgag 323281 tgaaggtgcc tgtcctgatg tcaatcggcc tgattgacaa ggtcacgccg ccgtccaccg 323341 tgtttgccgc ctacaatcat ttggaaacaa agaaagagct gaaggtgtac cgctacttcg 323401 gacatgagta tatccctgct tttcaaactg aaaaacttgc tttctttaag cagcatctta 323461 aaggctgata aatgtgaaaa gccgccgcat atcatcaggc ggtttttttc tgcaaactgc 323521 cggaatgaga acagactgga gacgaataga tatgaaacaa agaatcattg atgaattaaa 323581 acggatcgag cagtcatacg gagtcaaaat cgtgtatgcc gtcgagtcag gaagccgcgc 323641 atggggattt ccctcgcagg atagtgatta cgacgtccgc tttatttatg ttccgaaaaa 323701 ggagtggtac ttttcaattg agcaggagcg tgatgtcatt gaggaaccga ttcacgattt 323761 gctggatatc agcggctggg agctgagaaa aacgcttcgg cttttcaaaa agtcaaaccc 323821 tccgctactc gaatggctgt cctcagacat tgtgtattat gaagcattta cgaccgcaga 323881 gcagttaaga aaactccgca cggaggcatt taagcctgaa gcaagcgtgt atcactatat 323941 caatatggcg agaaggaacg tcaaggatta tctacaagga caagaggtca aaattaaaaa 324001 gtacttctac gttcttcggc ctattttggc ctgccaatgg attgaaaagc acggaaccat 324061 accgccaatg gactttactg ttttgatgaa tgaacttgtt gctgaacccg agctgaaggc 324121 tgaaatggaa accttgcttg aacggaaaag aagaggggaa gagcttgacc tcgaagcaag 324181 aatcgatgtt attcaccaat tcattgaaac ggaaatcgaa agaatcatgg aagcggcaaa 324241 agaactgaag gcagagaaaa aagatatgac atctgaattg aaccgtttgc ttttgaatac 324301 ggttgaagaa gtgtggaagg atggaggaag ctgatgtttt ttgtcgcttc cttttctcct 324361 ttattcgaca gaatcccccc ccgactttct aactatctga ttgtggcaaa cccacaaaaa 324421 taatcagaat ctttgtattt tgagaatatt gtgaacgctg gttttgtcca tttacaataa 324481 actcatacaa atacttctta gattgcgggg tgttgaggtt ggaagtgatc acaagagatt 324541 ttttcttatt tttatccaaa agcggctttc tcaataaaat ggcgaggaac tggggaagtc 324601 gggtagcagc gggtaaaatt atcggcggga atgactttaa cagttcaatc ccgaccattc 324661 gacagcttaa cagccaaggc ttgtcagtta ctgtcgatca tttaggcgag tttgtgaaca 324721 gcgccgaggt cgcacgggag cgtacggaag agtgcattca aaccattgcg accatcgcgg 324781 atcaggagct gaactcacac gtttctttaa aaatgacgtc tttaggtttg gatatagata 324841 tggatttggt gtatgaaaat atgacaaaaa tccttcagac ggccgagaaa cataaaatca 324901 tggtcaccat tgacatggag gacgaagtca gatgccagaa aacgcttgat attttcaaag 324961 atttcagaaa gaaatacgag catgtgagca cagtgctgca agcctatctg taccggacgg 325021 aaaaagacat tgacgatttg gattctttaa acccgttcct tcgccttgta aaaggagctt 325081 ataaagaatc agaaaaagta gctttcccgg agaaaagcga tgtcgatgaa aattacaaaa 325141 aaatcatccg aaagcagctc ttaaacggtc actatacagc gattgccaca catgacgaca 325201 aaatgatcga ctttacaaag cagcttgcca aggaacatgg cattgccaat gacaagtttg 325261 aatttcagat gctgtacggc atgcggtcgc aaacccagct cagcctcgta aaagaaggtt 325321 ataacatgag agtctacctg ccatacggcg aggattggta cggctacttt atgagacgcc 325381 ttgcagaacg tccgtcaaac attgcatttg ctttcaaagg aatgacaaag aagtaaaaaa 325441 ggagagatta tcatgacaac accttacaaa cacgagccat tcacaaattt ccaagatcaa 325501 aacaacgtgg aagcgtttaa aaaagcgctt gcgacagtaa gcgaatattt aggaaaagac 325561 tatccgcttg tcattaacgg cgagagagtg gaaacggaag cgaaaatcgt ttcaatcaac 325621 ccagctgata aagaagaagt cgtcggccga gtgtcaaaag cgtctcaaga gcacgctgag 325681 caagcgattc aagcggctgc aaaagcattt gaagagtgga gatacacgtc tcctgaagag 325741 agagcggctg tcctgttccg cgctgctgcc aaagtccgca gaagaaaaca tgaattctca 325801 gctttgcttg tgaaagaagc aggaaagcct tggaacgagg cggatgccga tacggctgaa 325861 gcgattgact tcatggagta ttatgcacgc caaatgatcg aactggcaaa aggcaaaccg 325921 gtcaacagcc gtgaaggcga gaaaaaccaa tatgtataca cgccgactgg agtgacagtc 325981 gttatcccgc cttggaactt cttgtttgcg atcatggcag gcacaacagt ggcgccgatc 326041 gttactggaa acacagtggt tctgaaacct gcgagtgcta cacctgttat tgcagcaaaa 326101 tttgttgagg tgcttgaaga gtccggattg ccaaaaggcg tagtcaactt tgttccggga 326161 agcggagcgg aagtaggcga ctatcttgtt gaccatccga aaacaagcct tatcacattt 326221 acgggatcaa gagaagttgg tacgagaatt ttcgaacgcg cggcgaaggt tcagccgggc 326281 cagcagcatt taaagcgtgt catcgctgaa atgggcggta aagatacggt tgttgttgat 326341 gaggatgcgg acattgaatt agcggctcaa tcgatcttta cttcagcatt cggctttgcg 326401 ggacaaaaat gctctgcagg ttcacgtgca gtagttcatg aaaaagtgta tgatcaagta 326461 ttagagcgtg tcattgaaat tacggaatca aaagtaacag ctaaacctga cagtgcagat 326521 gtttatatgg gacctgtcat tgaccaaggt tcttatgata aaattatgag ctatattgag 326581 atcggaaaac aggaagggcg tttagtaagc ggcggtactg gtgatgattc gaaaggatac 326641 ttcatcaaac cgacgatctt cgctgacctt gatccgaaag caagactcat gcaggaagaa 326701 attttcggac ctgtcgttgc attttgtaaa gtgtcagact ttgatgaagc tttagaagtg 326761 gcaaacaata ctgaatatgg tttgacaggc gcggttatca caaacaaccg caagcacatc 326821 gagcgtgcga aacaggaatt ccatgtcgga aacctatact tcaaccgcaa ctgtacaggt 326881 gctatcgtcg gctaccatcc gtttggcggc ttcaaaatgt cgggaacgga ttcaaaagca 326941 ggcgggccgg attacttggc tctgcatatg caagcaaaaa caatcagtga aatgttctaa 327001 gcgggactaa atgggcatcc tccctgcggg ggtgtccatt tcatccatat actataaaaa 327061 agaggaggaa gtgccataga aaacacacag ctgattattt cgatttgtat ttatatggcg 327121 ggaatgctgc taatcggcta ctttgcttac aagcgtacgt cgaatctgac ggattatatg 327181 ctgggaggac gctctttggg tccggcagta accgctctca gtgccggcgc tgccgatatg 327241 agcggctggc tgctaatggg gcttccgggc gccatgtttt ctactggtct gagcggcgct 327301 tggatcgtca tcggactttg ccttggagcg tgggcgaact ggctttacgt cgcaccacgg 327361 ctgagaacct atactgaaaa agcggggaat tctattacaa ttcccggatt cctggaaaat 327421 cgcttcggag atcaaacaaa gcttctcaga ctgttttcgg gaattgtcat tttagtcttt 327481 ttcacgtttt atgtatcgtc cggaatggtg tccggcggcg tcttattcaa cagcatcttg 327541 gggatggatt atcacaccgg cctgtggatt gtgacgggtg ttgttgtggc atataccctg 327601 tttggcggct ttttggcagt cagctggaca gattttgttc aggggattat tatgtttgcc 327661 gcactcattc ttgtgccgat cgttacgttt ttccacacgg gaggagcagg tgatacagtt 327721 gctgaaatcc gctctgtaga tcctgatatg tttaatattt tcaaaggaac gagcgtcctt 327781 ggcattattt ctttgtttgc ctgggggctg ggatactttg gccagccgca tattattgtg 327841 cgttttatgg cgataacgtc tgtcaaagag atcaaaagag cgcgcagaat tgggatgggc 327901 tggatgattt tgtctgcagt aggcgcagtg ctgaccggtt tgggcggaat cgcttattac 327961 catcagcgcg gcatgacact gaaggaccca gagacgattt ttattcaatt agggaatatc 328021 ttgttccatc cgattatcac gggttttctg atttcagcga ttttggccgc gattatgagt 328081 acaatttctt cccagctgct tgtgacatca agctctctgg tagaagattt gtataagtcg 328141 atgttcagac gctcagcttc agataaagaa ctggtgtttt taggccgact ggctgttctg 328201 gctgtttcaa ttgtcgcgtt ggttctggct tgggagaaaa ataacaccat ccttggattg 328261 gtcagctacg cgtgggcggg cttcggtgca tcattcgggc cagttgtact gctcagtctg 328321 ttttggaaac gaatgaccaa atggggggca ctcgccggca tgattgtggg agcagcgact 328381 gtaatcattt gggcgaatgc cggtctttcg gactttctgt atgaaatgat acctggtttt 328441 gctgcgagtc tattatctgt cttttttgtc agcatattga cgcaggctcc gtcacaagct 328501 gtcacagacc agttcaacga ctaccaagat acaatgtcgc aataaagatc gaaaggagga 328561 ggaaggggct gtcccttttt cctcttttct ccttttaagc ggccattttt ttcttttgga 328621 aacaaacgta tttttttcta tacaaaaaga ccccgtatgg atatgattaa agtaaaaaaa 328681 gtataggaga aaaaggtatg gaagagcttt tagagagagt tttttcattt tcagatgttg 328741 ataagctaat tgattttatt agctatgaac tgcaaaagcc agtgatactg gaaagcgcgg 328801 atttcttttt gttagcctat aattcttact atattaacca ttttgattct gccaaccagc 328861 agactatttt ttcgaaaaag tgtccggtcc agatttttga gaggtttctg aaggacggaa 328921 ttattgaaaa attgaaaaca gagcctgagc cttttcgcgt caataaaatt gaaagcattg 328981 ggttaaacca gagggtggtc gtgagtgcaa agcacaaagg ggaagtcatg ggctacatct 329041 ggattcagga gctggaccaa aatctgacgg atgaagagct cgactttttg tacgagacct 329101 ccttccatgt cgggaaaatc atttataaaa cgaataaatt gaaacaggaa aaggaagaaa 329161 aagcagagga tctcatcaaa cgggcgatct atcagcaatt tacctctgag aaggaactca 329221 gacgggaagc tgaaaggatc aacaccgtgc tgccttccat gttttcagtt gttatcctgc 329281 acgccgcaaa tggggatggg gaagcggttg aggatttaaa ggaaaatatc aggtcgtacc 329341 tgaatttacg ggataaggtc agtcatgtct taacgatcga atcaaacatt gtcatcgtcg 329401 tagcgagttt ttcccaaaaa agctccgtct cctcagcagc ttctgagttt attaacaagc 329461 tgttaacaca ttttcacttt caaaaaatac ctacccctat ttatatcggt atcggaaacg 329521 aatataatca cctattaaaa cttggcaaga gctacacaga agcacttgaa gtcatcaaag 329581 ccgcagaaat caccggcaat caggaaaaca ttccatatga atatgccaaa ctcggcattt 329641 accgctattt agaaagcatc gaacagaaaa atgaattttt agaatacgag aataaagatt 329701 tagctttatt aaaagcaaaa gacgaagaaa gcagcactga gctgctcaaa accttggaaa 329761 tctatctcct caacaactgc aaaacaaaac cagcggcaga acagctgttt attcaccaaa 329821 atacattgaa ttaccgcatc aaacagatta ctgagatgac gtcgatcgat ttaagcgatt 329881 tcagaacgcg gtgccagctc tatctcgatt tgatgctgat gaaaaagaaa taaaaaagaa 329941 accagtactt gtactggttt cgtcttcact taaaatcctc tgtaaacata cggatcatca 330001 ggttttttaa tggtattcca gtcagttact ttgacgacag ggagagttga cttgaatggc 330061 tggtaatatt ctgaggccag agtgccctta atgtgaatcc attcatcatc cttgatgtcc 330121 atgtccttcg gaaattccac aagcatcccg tacacgccgg aatcagcgat acagtgaatg 330181 atgccaaacc ttaatacgaa cagctgattt ttgttaattg cgtttccttt gtaagcaaat 330241 ccatgaaatt ctatcgtccg tccgagaaat tcacccggat agttatagat ggtttccatt 330301 ccttttagga aatcgtcatc ggtcagagaa atctcttttt tgctggaata cttattaaac 330361 agctgtttca tttgtttgtc atagctgtct tgcgcgtaat aaaggctggc atcaggccgc 330421 aaatactgtg tttgggagta gtgatctccg ctctccatcg ccttaaacga gaaccctttt 330481 gttttgacta tggatgagtc aagcgttgca atcgggaaga agatgcctga caccaaagga 330541 aaaagaaaaa caacataaat caaataacgc tgataaaatg gcttgttttg ttcatggtca 330601 tgctcgtgat catggccgca cccgcaatca tggtcatggt gatgtccgct tttttcaggc 330661 gacttgataa atagatatgc ttggacggcg gtcagaatgg ccagcaggaa gatcgcaata 330721 aaggaaagat aggcatattt catattgata tattttgtta gatttcctga ggcatgcaga 330781 tgataaaaga aaaacgtaaa tcccatcagc accaataaac gaaacatcca atcacccctt 330841 taccagtagt gatcccgcta aaacaatcac gacaatgtat gtaatcagca ggaaaacaaa 330901 tcgttttttg aaggccgcaa gcatcatcaa tagattctta atatccacca ttgcaccaaa 330961 gacgagaaag gcgattaacg atcctaatga aaacgtgctg ctgaaggaag acgcgatgaa 331021 cgcatcaact tctgaacaaa gcgacaggac aaacgccaga cccatcatca cgagggaaga 331081 ggatacatca ttctgcccga tcgcaagcag agtggatgtt ttgacatacg tctgcatagc 331141 ggctgcgata aaggcgccga tgattaaata tttccccacg gagaaaaatt catcaatggc 331201 atgccgcaag gtcccgccca gtttttggag caaggtgccg tgatgatgat ggtggtgccc 331261 gggttcatca ggctttaaaa gctggttatc cttaaattga taggataaga tgaccccgat 331321 gatcagcgaa acggcgagag ccagtccgcc tctgtaaaag accacgctcc atctattccc 331381 gaacgcaata taagtagaaa ataaaacgat aggattaatg ataggcgcgg tcagcatgaa 331441 agcaacgccc gcatgcagag gaactccctt taacagaagc cgcctcgtaa tcgggatgat 331501 gccgcattcg caggcgggaa ataaaacgcc ggccagcgca ccgaataaaa cggcgagaaa 331561 acggtttttc ggcatgattc ttgcaatcat ttcttcagaa acaaacattt gaatgattcc 331621 ggaaagtatg acgccaatca gaataaacgg aatggcttct attaaaatgc tgataaaaat 331681 agaattcagc tgaagaaaag atgattgtgc tgtcacaata aaacctccgc tcatgttaag 331741 ctgcctttct tatgatacca gaaaaaaagg cactgcttgt ttgacggagg aggggaaagg 331801 atcgtttcac tttggttagg attccaaaaa gccgagtagg atactgcctg tttctgcagc 331861 ttcttttccg agccaaatca ggtgtcccca tgagtgaagc aaacagagaa cagcgccacg 331921 aatgtgctct tttgcatgat gtgcatgtga caagtcaacc aatccgtcat aaacactttg 331981 cataatcagc acgggacata tgatggcttg caggtctttt aaagagacag cggcggtttg 332041 tgacaagtca atcagaaatc cttcacccga gcgctgccgg ctgttcattt tccgaaatgc 332101 ttctatgtct ttttcattca tcaaggactt gattcgctga aacggaagcg tgctgaattg 332161 ggggctcata gctcgaaaca tcaaacgcgg gaaagcgtta ttcaaggaag aaatcagctt 332221 ccatatccac ttttccaccg gcgggcggaa gagaatttcc cccaatttat attcagtgtc 332281 ttttggggtg agccactctt tggtgactgc ggattgcagg gtcaatgtat ttactctttc 332341 cggataatgt gaggcaaagc atatgccgct cggccctcct gctgagatgg cgatcacatg 332401 gacactctcg atttgtagat gatctaataa tttcacatag aaacggcagg cattggcaag 332461 actttttcca atttcttttg acgtccgtcc atagccaggc cttgaaggcg taatgatgga 332521 atacccttgt tcaatcaacg ctgtgtatcc gaattcctcg taacaatttg aatgcccgcc 332581 atgcatgaca aggatcggag ttcccttgcc tgtcacagaa tattctagtg taccgccatc 332641 gaaggtgatc gtttcaactc gtcttttcat ctgtttcacc caattggttt ttgcctatta 332701 tagagttttc agcaattgac cacaaggtag aagaaatgaa taaacaaagg cccttgaaat 332761 atgatatact ttgtattgat attcattctc aattaaaact ttgatataga tgtgaacggg 332821 aggcaggacg gatggctgag aatcaagagg tatatgacgt tacgattata ggcggggggc 332881 cgatcgggct gtttactgct ttttactgcg ggatgcggga gctgaaaaca aaggtaatcg 332941 aatttttgcc gaagctcgga gggaaggtgt ctttattctt tcctgagaaa atcattcgcg 333001 atatcggcgg cataccgggg attgcgggaa agcagctgat cgagcagctg aaggagcagg 333061 cggcaacgtt tgatcctgat atcgtattga atcagcgtgt gaccgggttt gaacgcctag 333121 atgacggcac cattgttctg acgggttctg aagggaaaaa gcactataca agaactgtga 333181 ttttggcttg cggcatgggt acacttgagg tcaatgagtt tgacagcgag gatgcggccc 333241 gatatgcggg caaaaatctt cattatggag tggagaagct cgatgcgttt aaagggaaac 333301 gcgtggtgat atcaggcggc ggagatactg cggtcgattg ggctaatgag cttgaaccga 333361 ttgcggcgtc tgtgactgtc gttcatcggc gtgaggaatt cggcggaatg gaaagcagcg 333421 tgacgaaaat gaagcaatca tcggtgcggg tgcttacgcc ttatcggctg gagcagttga 333481 acggagatga agagggcatc aaaagcgtga ccgtttgtca tactgagtct ggccagagga 333541 aagacataga aattgatgag ctgatcatta atcatgggtt caaaattgat ctcgggccga 333601 tgatggagtg ggggctggag attgaagaag gaagggtgaa agctgacaga catatgcgaa 333661 cgaatcttcc gggcgtgttt gtggcgggcg acgcggcttt ttatgaaagc aagctgagat 333721 tgattgccgg cggatttacg gaaggcccga cagcggtcaa cagtgccaag gcttatctgg 333781 accctaaggc cgagaatatg gcgatgtatt ccacccatca taaaaaattg gtgcataaat 333841 aaaacagccc ttgaggaaaa gggctgcttg ccatcaggtg tgaaggagtt ttttctctgc 333901 atgttgattg tggatgaaag ctagcaattc atcctgttct tgtacggctg tgaatccata 333961 aatgccggca gctgagtcat cgcctatgca gacgatagga gggcggcttg ctgacggttc 334021 cggcaaaatg ccaatttgtt cgccaccatt gatcaattgc tgaacggaca gcttgtttgg 334081 gcaaatgacc atgtgcagcg gggattcact gatggtacgc tgaatcatgt gggtgaaccg 334141 gtcatctatg acgttttcat gagtgatata aaacgaacag gattcatgct tttgcatgtt 334201 ttccactgca tggcggctcc cgacaacaag acgtttctct gaatcaggct gaatggcggt 334261 gacaagaaag ccccgtttct caagctctgt ctttgcttgc tcagatgctg cactcagttt 334321 ggctgtcagc tggcggatgt cgattttctg agaagccagt gctctgaaaa attcacaaac 334381 cgcccggcgc gatgtgaaaa aaacgtcttc aaaggtgcca atctttcgaa gaatttcttc 334441 attgacaggc atgttttcgg tccgccattt cggccactcg atgagatcgg cgccggaatc 334501 gcgcagcttg tctgcaagcg ggtcttcatc ttcgccatga gtcacaacca tcaaatgccg 334561 tccgatgagc ggtttgcttt caaaccagct gtgtgtttga aagttgacga tgtctccgat 334621 gacgataatc gcagggtttg taatctggtg ttcctgcact ttttgctgaa tgttctcaag 334681 tgttcctttc acactccgct ggcggcccca cgttccccat tggatgacaa tgacagggac 334741 agaaggcgat ttcccgtatg aaataagctg ctggcaaata taagacaagt tcttgacacc 334801 catgtaaaaa acaagggttt gaacgcttcg ggccagccct tcccagtcaa ggttcggcgt 334861 gccttttaat gatttatcat gcgctgtaat catggcaaaa gacgatgcaa aatcccgatg 334921 cgtgacgggg atgcccgcat atagcggcgc tgcaattcca gaggtgattc ccggcaccat 334981 ttcatagcga atgccgtgct catgaagagc atctgcttcc tcgccgactc tgccgaatac 335041 gctcggatct ccgcccttca agcgaacgac ggttaaccca tttaatgctt tttcaaccag 335101 cagggcgtta atttcttttt gtttcataaa atggcggttt ggcagttttc cgcaataaat 335161 aaactggcag tccggtgatg caaattcgag cagcttcggg ttggcgagcc ggtcatataa 335221 aatcacatct gcttccttga gcgcctgttt tcctttgatg gtgagcaggc ctgggtcgcc 335281 gggtccggct cccacgaaat atacgattcc gttcttcatg atcatgtcat ccttccgtca 335341 ctgtaaaaaa tgaaggacca ctagaaaagt gatccggtct tttgatcaat atacgagata 335401 aacatgttct ccttcgatca gcgtttcata tgttttgacg catccgtggt caggttcttg 335461 gacgattccg tcttctaagg aaattttcca gtcgtgcatc gggcagaaaa catattgacc 335521 gctgacgatg ccttctgcca ggacgccgcc cttatgcgga cagcggtttt caatggcgcg 335581 gatgcttccg tctgaaagct tgaaaaccgc gagctcctta tcttcaatat acactgtttt 335641 gcctaattgt tcaggcaatt cttcaatttt tccgatacat acttttgtta cgtctttgtt 335701 taccatgtcc attcctcctc aatgatagtt tttgtcatta tgatgtggtc acgacatttt 335761 caaataattc tttagaggtt tgtttatcct ctaaaaagtc tttccacgga tccttgtgga 335821 cagagagtgt ttcattcatt cggccgttca gctcctgccg cttttccgga tcgtttaaca 335881 cggattggac atgggataaa ccgacgcgct caagccatgc ggacgtacgc tccagatagt 335941 ttgcggtttc cctgtaatat tgcaggtaag cgcccgcgta ttctaagact tcttcatttg 336001 ttttcacctt catcagcaaa tcgccggcac gcaaatgggt tccgccgttt ccgccgacat 336061 aaagctccca gcctccgtcg atgccgacaa cgccaaggtc cttaatgccg gattccgcac 336121 agtttcgcgg gcaggcagac acggccattt tgactttgtg aggcgtgttc agcccttcga 336181 attttttctc aagcgcaatg cccagtgcca tggagtcttg tgtgccgaag cggcagaatt 336241 gctcgcctac acatgttttc actgtgcgga gcgtttttcc gtacgcgtag cccgatggca 336301 tatcaagatc ttcccatacc ttcggaaggt cttctttttt cacgccgata agatcaattc 336361 gctggccgcc tgtcattttc acgagcggga tctcatattt gtcaacgaca tcggcgatct 336421 tgcgcaaatc tgtggagttg gtcacgccgc cgtacatccg aggaacgact gagtatgttc 336481 cgtctttttg aatattggcg tgcattcgtt cattaacaaa gcgggatgtc cggtcatcct 336541 cgtatttggt tggattgatc atgcctaagt agtagttcag agcgggtcgg catttagaac 336601 agccttctgg cgttttccag ccgagcacat tcatgacttc tcttgtatgt gacagccctt 336661 tggctttgat ttcttctacg acttcatctc tcgacaatgt ggtgcagccg caaatggctt 336721 ctttttgcgc tgacgcatca aagtctgatc cgagcgtatg ctggaggatt tcttctacga 336781 gcggcttaca gcctccgcat gagcgggatg cgccggtgca tgctttgatt tcgtccgttg 336841 acgagcagcc cttttcctgt atggcttgaa taatcgcacc ttttgacacg ccgttacagc 336901 cgcagatgat ttcatcgtcg ctcatcgctg cggttatgct tgtgcctgct tcctggctga 336961 ggggctgtaa gattgatatt ttagaggttt cagagatatc ggcttctttt tgaatcatag 337021 aaaacaggcg attgccttcg ctgctgtcgc cgaataaaac agcaccgaca atttgattgc 337081 ctctcaggac aattttttta tagatgccgt cctgctcatc gaagacttta atcgcttttt 337141 tctcctctga ttcgttaaag tcaccggcag agaagacctc gacgcctgat acctttaact 337201 gtgtggagag aacggagccc tcatacggtt ttgtttcgat gccgcacata tgctttgcca 337261 gcacttttgc ctgttcatac agcggcgcca caagcccgta ggcgattcct cggtgctcgg 337321 cacattcgcc gaccgcgtaa atgtgcggga tttcagtctg catataatcg ttgacgatga 337381 tgccgcggtt aaccggaatg ccgctctcgg ccccgagcgt tgtatttggg cggatgccga 337441 cagccatgac gactaaatca gcttcaatgc ttgtgccatc cttgaatcgg aggccttcga 337501 cacggtcgtc accgacaatt tcttctgttt gcttttcaag taaaaaggtc ataccttgtt 337561 tttctaactc gttttgcagc aggcgtcctg ccgttgcatc aagctggcgc tccatcagga 337621 atggggcaag gtggatgacg gacacgtcca tgccgagatt cagcagtccg cgagctgctt 337681 ccaaaccaag tagtcctccg ccgatgacgg cagctttttt atattgtttt gacgcggcga 337741 gcattgtgtc tgtatctttt atgtcccgga aagctgtgac gccttttttg tctgcgcccg 337801 gaatcggaag gataaaaggg accgatcctg tcgccaggat caattcatcg taaggctgga 337861 ttctgtctgc atctgtgatg actgttttgt tttccgtgtc cactttgatg actgtttcat 337921 ttgtatacaa ttgaatgttg ttttcttcgt accagtccca atcgtttaac gtaatatctt 337981 taatatctgt atcgccttga agcacttttg acaaaaggat tcggttgtaa ttgggatgcg 338041 gttcggcacc gaaaattgtg atctgaaact cgtctttagc aacactcagt atctcttcaa 338101 tggcccttac cccggccatt ccattaccaa caagaactag ctgttttttt cccatcagat 338161 gatccgctcc ttatcaaatg ttttttccag cgtagcacag caaaaaggaa tatttaagat 338221 acatgttata aaatgtaaca aaatatacga aaagttctaa aaattttatg aaaaatttaa 338281 ataggtatga ttcggacggc gcatacctta aaaccgggca ttttacaggc tggatctaag 338341 gcttccccga ttaaatcatt cacattttga gcgtctgccc aatggatggg aacaaaaacg 338401 gtatcttttc tgatttgttc tgataatttg ctgcggacgg tgatgcttcc ccgcggcgat 338461 tctattttta ccagtacacg gtcctcgata ttgtaggtcg ctgctgtttg cggatggatc 338521 tccataaacg attcaaaatg tctcgcggca agggcggcgc tttttcttgt ttggacgcct 338581 gttaagtagt gagacatgac tctgcctgtc gttaaataaa gcggataatc ggctgtcggc 338641 ttctcttttg gaacaggtgg ttcgtttgga atcacactta atgccgcttt ttgatccgga 338701 tgagcaaatg attctgtaaa caagcgccca gttccgggat gatcagattc cggacacggc 338761 caatgaatgc cgccttcacg tctgagcctg ccgtatgaga tgcctgaata atcggcaatc 338821 ccgcctcggc tcgcttctct caattcattg aaaatatcct ccgctgacgt ataagaaaag 338881 tagcggccct tgccgagagc ggatgcgaga tcacaaatga tctgccaatc atgctttgct 338941 tcgccggggc atggccggct tgcttctctt aatgtcacgc gtccttctac atttgtcatg 339001 gtgccttcat cttctaagta agaggaggca ggtaaaatca catctgcgta tttcgcagtc 339061 tcagaaataa acaaatcgat tgcgacaaag aatgtcagtc ttcttaaagc ctttttcacg 339121 agatttgcat ttggactgga aacagcaggg ttggagcaca tgaggaacag tcctttgatg 339181 tcgccgtcat tgattttttc catcatttca taggctgaga caccttttcg cgggagttca 339241 tcctgatgga ttccccacac tttcgcaata tgcgcccggt gttcttcgtt ttcgatagaa 339301 cggtagcctg gaagctgatc ggctttttgg ccatgctctc tggcgccttg cccgttgcct 339361 tgtccggtga tcgccccgta gcccgagtaa ggtttgccga tttttcctgt gatcagcacc 339421 atgtttaaga agcctttcac agccgctgtt ccatcggttt gctgttcaat cccgcgggct 339481 gtaaacagca tgccggacgt ttccttggca aacttcacag cagcttttct tatatccacc 339541 agcgagacac tcgtctgttc ggcgatgtca ttcaggtcca acgagtcagt atgctgcttc 339601 agctcttcga atccatttgt tcgtgattga atgaaatcct cgtttataag ctgttcgtca 339661 atgatgattt tgacgagacc gttggcaagg gcggcgtctg tgccgggttt gattttcaga 339721 tgaagatcgg cgattttcgt tgtcgctgtt tcacgaggat caatggcaat gaagtaagct 339781 ccgttttctt tcgctttttc aaaatacggc ataatcgtag gctggcattc cgcaatattg 339841 gtgccggcca gaatgatcac acgggtgtgg gggatgtctg ataaaggatt cgttaagcct 339901 ctgtccgcgc cgaatgtttg gttggctgcg gtggctgctg cggacataca aagtctcccg 339961 ttgtagtcga tgtattttgt ctgtaagcct actcgtgcga acttccctaa caaatacgcc 340021 tcttcatttg taatcgaggc gcttccgtat accgccatgg cgtcatgtcc gtgttcagtt 340081 tggatcattg tcacttggtc tttgatatga ttcagtgctt cttcccagga aacaggcata 340141 aactcgccgt ttttcttcag cagcggccgg gtgatgcggg aggagttcaa ggcatgctgg 340201 tgagcattca tgcccttgat gcatagccga ccctgtgtcg taggattatc aatcccgatc 340261 gcagtgtact ttttgcgcgt gacgatggtt tgttccacga gctgcatttt gcactgcatg 340321 ctgcaaaacg ggcattgagt gtcatatgtt ttttctgatt ggacgtcttg ctgtttatca 340381 cggaaatatc taagcagtcg ttcagtcaaa atgcctcatc ctttcttata tgcgcccgtc 340441 tctacagtcg ggttttgaat cagtgacaga tctgtttgga ggctttccag cagctgtgcc 340501 cttaggtctt cttcgaatag cacttctctg atatgaacga tcccgagacg gtctatccac 340561 tgatgaacac cttctaagta atgagccgtt tcccgataat actggatcag tcctttgatc 340621 atgccggcag tgctgtcttc gttctcagtc acgcaaaaca aagctcctga acgggcatga 340681 gttccccgga cgccgccgat gtgaatgtcc cagccagctt gtgtccgaat tgcgccgaca 340741 tcttgcaggg cggcctcggt gcagtctgtt tcacatgata agctgataga aatgggagcg 340801 ggtaagggaa gcatctcaag ttgtctttcg atttgggctg ccagctgctg aatcgatcga 340861 ttttgcccgc atgtacatgc tttgatgctt tgcagcgcgt gtcggtgttc attagtgtaa 340921 acgggcattt tcaggtcttt tttcatgttc gggagatccg caggcttgat cccggaaagc 340981 ttcagccttt ggccgtgagt gatggatacg tcgggaatgc tgtatgcctc aatgatgttg 341041 gcgatggttc ttagctgctc cgcgtttgtc cgcccgccgt acatttgcgg aatcaggatg 341101 catgtctctt cagtggctgg ctcaggctgg acaaacccag ggtacagcat ttccagatag 341161 tattgaatcg caggaacaca agtactgcat ccgttttttg ttttccagtc aagctggttc 341221 atcacttctg ccggattagt gaatggcctg cgctgaagct cagcgatgat gtcgtcttct 341281 gtaaaatcag tacagctgca aaacgaaggt gtgctggcgg gcttcgtata ttcgctgttg 341341 gtcatgtatc tcaaaaggtc ttcaacgagc ggtttgcatc ctccgcagga cccagtggct 341401 ttggtgcagt gcttgacttc ctcaacagtt gttaagctat tcgtgtgcac cgcgtcttca 341461 atcgcgcctt tcgtcactgt gttgcattgg caaatcgttt cactggaagg catggattca 341521 aataaagggc cgcttgtctc cggttcgatg atctgttttt tggcaatgga gatgtctcgt 341581 tgtttaagca ggctgtcgag aagccgctgc ttgtcacggg tgtctccgaa taaaataacg 341641 ccggccagtt tgtcatctac aaaaagcgct tttttataaa cgcctgcttg ttcgtcgtag 341701 attttgatgc tcgtcgtgcg ttcatcctct tggatctttc ctgctgacca cacatcgatt 341761 ccagctattt ttaacgccgc agatggtgct gagccttgat attcctcaca tggaacgccg 341821 caaatatgac tggcgagcgc ttttccctgc tcataaagcg gagccaccaa tccgtacacc 341881 gttccgttat gctcagcgca ttcaccaacg gcgtagatat tcggttcgct tgtctgcatg 341941 aagtcattca cgatgatccc gcggttcact ttgattccag cggatacagc caattcaata 342001 ttcggtttga cgccggccgc catcacaatc aagtctgctt ttaatgaaga gccatcttta 342061 aaatggattc ggtctgcctt cgtggcgccg gaaatggaga cggtgtcttt ctccaaaaga 342121 aaggttaggc ctttttgttc cagctctgtt tgcagcagcc gcgccgctgt ttgatcgagc 342181 tgtttttgca taatgccggc ggagtggtga atgacgctga catccatacc gagatgctgt 342241 aaacctactg cagcttccag tcctaataag ccggctccga ttaccgcagc cttttgaaag 342301 tgctgggcca tgttcatcag cgcttggcag tcttctattg tccgaaatcc atagacacct 342361 tttttgtctg ccccggggat agggagaata tgaggggagg agcctgttgc cactattaat 342421 ttgtcatacg acagagtgcg tttccgatct gtgatgacct gctgctgatc tgtatcaatc 342481 tgaataaccg tttcgcctgt gtaaagcgtg atcccgtgct tgtcgtacca atccttgctg 342541 ttcagtgtaa tatcatcgag tgacgcttca ccctgcaata cagaggataa gagaatgcga 342601 ttgtaattgg gatgcggctc gcttccgaaa atgacaatct caaacatgtg gcgattcagc 342661 tttaatactt cttcaataca gcggattccg gccatgccgt ttcccgctaa cactaatctt 342721 tgtttcttca tgtatcagac ctcctttggc gaagctcgta agttttctcc tattaaaaat 342781 tatgtcacaa tgcattgtta acgcattaaa cgtgtcacaa aaacttacac atgtcttttc 342841 cagaaaataa tggtcctata tccttgattc agaaaatgta aaataatgag ggtctagaaa 342901 ggggaatctt atgaagctgt cggaactgaa aactagcggt catccactca ctttgctctg 342961 ttccttttta tactttgatg tcagttttat gatatgggtt atgcttgggg cgctgggtgt 343021 ttatatttct caggattttg gcctgtctcc ttttgagaaa gggcttgtcg tagctgtgcc 343081 gattttatct ggatctgtgt ttcgtatcat tcttggtatt ttaacggaca gaatcggacc 343141 gaaaaaaacg gcagtgatcg ggatgctggt gacgatgatt ccgctgcttt gggggacatt 343201 cggcggccgt tccctgactg agctgtatgc catcgggatt ctgcttggcg tggcgggagc 343261 aagctttgct gtagcgctgc ctatggccag ccgctggtat ccgcctcatt tgcagggact 343321 tgcgatgggg attgccggag cggggaacag cggcacgttg tttgcaaccc tgtttggccc 343381 tcgtctggca gagcagttcg gctggcacat tgtcatggga attgcgctaa ttccattatt 343441 gatcgtcttt attctttttg tatccatggc aaaggattcc cctgcacagc cgtctcccca 343501 gccgctcaaa agctatctgc atgtgtttgg gcaaaaggaa acatggtttt tctgcctgct 343561 gtacagcgtc acatttggcg gatttgtcgg gctctcaagc tttttatcta ttttctttgt 343621 tgatcaatac cagctgtcaa aaattcacgc aggggacttc gttacattat gtgtggcggc 343681 ggggagcttt ttccggcctg tcgggggctt gatttcagat cgtgtcggcg gcacgaaagt 343741 tctttctgta ttgtttgtca tcgtggcact gtgtatggcc ggagtcagta gcctgccatc 343801 tctctcaatg gttattgttc tattgtttgt cggaatgatg gggctcggaa tgggaaacgg 343861 cgcagtattc cagctcgtgc cgcagcgctt ccgcaaagaa atcggcatgg tgacgggaat 343921 cgtcggtgcg gccggaggaa tcggagggtt tttcttgccg aacatcttag gatctctcaa 343981 acagatgaca ggcacatatg ctatcggttt tatcacgttt tcctgtatcg cgctgctggc 344041 gtttgcactt gtgcttgccg caggctatta ctggcggaaa agctggagcg cggaaagcag 344101 cccggcggat gtttaggatt ttgacggaca cgcgtttgtg cgtgtctttt ttattttctc 344161 ttgattttca acagtgaacc gatcaaaata aatagtaatt attacgattt gttagtgaga 344221 ggagttttct gaatgaatca acatacgctg ctcccgaaaa aaacggagcg tcttcaatac 344281 tttggatcgg tcagtccgat caaaggcgag aaaccagtgg aaaaagagaa aatgaaggac 344341 ctgcaaaata tcaggaagga ttattttttt gacattcagc atgtaggtgt agctaatgtg 344401 tcccatccag tcacaatcac ttctgccatg atgcctgccg agcaaacaac ggctgcgaac 344461 tttacaatga cttgtaattt gccgagaaat cagaagggga ttaacatgag ccggttaaca 344521 gagctgctgc aagtctatca tcaaaatggc tggattctct cattttcctc tcttcagcaa 344581 tttacgaaag agcttgcaga aaacatggac acatcatctg ccacagttga agtgaggttt 344641 ccgtggtttt tcgaacggaa aagcccgaag cttgagaaag cgggtttgat gcatgctgat 344701 atattcatgt ctgtcaccta tcgcaaagat cagccgttta aacagcgtgc cggcatctca 344761 gcaaaagtaa cgactctgtg cccttgctcc aaggaaatca gcgaatacag tgcccataat 344821 cagaggggaa cggtcagcat ttgggcggat attcacccgg ccgcatcgct gccaagtgat 344881 gttaaagctg atttgcttca cgccgcagaa tcaaatgctt ctgcgagact gcatccggta 344941 ttgaagcggc ctgatgaaaa agccgtgaca gaaacggcct atgaaaaccc gagatttgtt 345001 gaggatctcg cccggctgat tgctgcagat ttgtttgagc ttgaatgggt gtcagccttt 345061 gagattgaat gccgaaatga agaatcgatc catcttcacg atgcctatgc gaagctgtgt 345121 ttttcgaagg aagtggataa aatatgaaac tctcattatt cattattgca gttcttatgc 345181 cagtcatcct gctgtcagcc tgctccgatc atgcagaaga acacgcaagt atcaatacaa 345241 agaaaacggt cgaaaacata acggacgttc gaaaaacagc aaaaacaagc attgattgga 345301 caaagccttc gggcggagaa tacccggata ttaaacagaa gcatgtctgg attgatgtga 345361 atgtgaagga gcagaaggct tacatcaagg aaggaagcaa caccatctat acaatgatga 345421 tttcttctgg tcttgatcaa acaaaagatg atgctacgcc aaagggcacc ttttatgtag 345481 agcctgaacg gggagaatgg tttttctccg aaggatacca ggaaggcgca gaatactggg 345541 tatcatggaa aaatcacggt gaatttttat ttcatagtgt gccaatgact aaggatcaaa 345601 aagtcatcaa aacggaagca gaaaaactag gaacgaaagc atctcacgga tgtatcaggc 345661 tgaccattcc agatgcgaaa tgggtatatg aaaatatccc tgaacataca aaagtggtga 345721 tcagctgaat tgaaaaccgt tgacaaaaag gaaaaaagac catacaattt aaatcgtaac 345781 aattacgttt tatgataaat ggcttatcat tgtctgtgca tctgtgaaaa gcggaaaggc 345841 atcgattaag gatcttgctg tcggcaaagg caaggatttg cgatggggaa aaggattaaa 345901 cgcggttgga gtctttactg atttagaaat cgggcggcag cgagaaatga gcgcgaaaag 345961 ctgctctaca ccattgtaca tacggcgaag tattcaattt aaatcgtaat cattctattt 346021 taatggaggc actattatga aaaaaattcc ggttaccgta ctgagcggtt atctcggtgc 346081 gggaaaaaca acattgctga acagcatttt gcaaaatcgc gaaggcttga aaatagcggt 346141 tatcgtaaac gatatgagcg aggtgaacat tgacgcgggc ttggttaagc aggaaggtgg 346201 cctttccaga acagatgaaa agcttgtgga aatgtcaaat ggctgcattt gctgcacgct 346261 tcgcgaagac ttattaattg aagttgagaa gctggcaaaa gacggacggt ttgattatat 346321 cgtcatcgaa tcgacaggaa tcagcgaacc gatcccggtg gcccagactt tctcttatat 346381 cgatgaagag atgggaatcg atcttacaaa attctgtcag ctggatacga tggtgacggt 346441 tgttgatgcc aaccgttttt ggcatgatta tcagtcaggc gaaagccttc tggaccgcaa 346501 agaagcattg ggggaaaagg atgaaagaga aatcgccgac ctcttgatcg atcaaattga 346561 gttttgcgat gtactgatct taaataaatg tgatttggtc agcgagcaag agctcgaaca 346621 gcttgaaaac gttcttcgta aactgcagcc aagagccagg ttcattcgtt ccgtcaaagg 346681 aaatgtaaaa ccgcaggaga ttttgcatac agggttattt aacttcgagg aagcgagcgg 346741 atcggccggc tggattcaag agctgacggc aggccatgcg gaacacaccc cggaaacaga 346801 agaatacggt atctcttcat ttgtatataa gagacgtttg ccgtttcatt ctacacgatt 346861 ttaccgttgg ttggatcaaa tgccaaagaa cgtggtacgt gccaaaggaa tcgtctggtg 346921 cgcatctcat aacaacctcg ctttgctgat gtcgcaagca ggtccgtcgg ttacgattga 346981 gcctgtatct tattgggtgg cggcgttgcc gaagcttgag caggagcaag tcaaacagca 347041 ggagccggaa atcctggagg agtgggaccc ggagttcggc gaccgcctaa cgcagctagt 347101 ttttatcgga actgacctgg atgaagaaac gatcacgaaa gagcttgatc aatgcctgtt 347161 gactgagtat gaatttgatt ccgactggtc gctgtttgag gacccgttta aatggaagct 347221 gaatcaatag aaaaaaagcc gtcccatggg gaacggcttt ttttaatgaa acgtttgttt 347281 aaacataatg agcgtatttt ttctcaagga tattctgaaa gaccgcggca atggagcaga 347341 tggcccaata aatgagagcg gtcagaatat acatggtcat ataatcaaac tctctgcccc 347401 cgatgatttt cgcatgctgg agcaattccg gcactgtaat catcgcagcg agagaggacg 347461 ccttgatcaa gtcgagcaat acattggcaa gcggaggcag cgcaatacgt atcgattgcg 347521 gcaaaatgat gcccctcatc gtctgccaat aggaaagacc cagcgaggat gcggcttccc 347581 actgtccttt ttcgacggat gaaatggctg aacggttaat ttccgcaatg taggcggcgc 347641 tgtttaggct aaagccgatt aaagcagccg tgacagcgga aaattcaatg ccgatataag 347701 gaaacccgaa ataaaggata aacaaaatca ccaaaatcgg aacgcctcgc ataaatgaga 347761 tatagagctt cgccggccat cttaacaaag caagtttaga cattctggcg agtgatatga 347821 acaggccgat cacagttccc gcaaacatgc ttacaaaaga gatgagcagt gtataaccaa 347881 tgccttttat gacataaggg aacgattcaa tggccagctt cgtgttgaaa atatattccc 347941 actgaatgct attgatcatg gcgtccgatt acaaatcaac gtcctgaacg tcggcatcaa 348001 ttttttttga tacatctgct ttattgaaga attgtttcga cagtttagtc aaagagccat 348061 ccttgctcat ctctttcaat gcttcgttca tctttttctg aagtgccgca ttgctttttt 348121 tcatgacaag ggcctgtttg ttcggcatgt acttgatgtc aggatgaatt gtaatgttga 348181 gatccgggaa tgccgcgagc gcaagtgtct gcaggtaata gtcgtttaaa atgacgtcag 348241 tgcgtccgtt ggcaacatct tttaaatatt gctcattcgt cgcattatca taaatcactt 348301 ctttggcgcc gtattttctc gcgacctcca tgtagacggt tgtagccgcg ccagccgctt 348361 tcttcccttt taaatccttg agcgttttaa tccctgataa atcgtctttt cggacaattg 348421 ccgtgccgta tgaatattta tatggagtgg aaaatgcgaa cttctcctca cggtccttcg 348481 tcacatcgat gtcattcgcg gctgcgtcaa cctgtccgct gttcaccgct gtcagcatcc 348541 cgtcaatgcc catctccttg aactcaacct tcagccccaa gcgttttgcc gcttcacgaa 348601 caacttcaac ctcgtagccc gtcagcttat cagagccaga gtcagtatcg tgataagaag 348661 tgggatagag cgtacctgat gtagcgacta cgattttccc tttatcctta atctgctccc 348721 agcctgtatc cttggaatcg gcttcatttt tgccggaaca ggctgccaat ataagaaaga 348781 aagccattgt gaaactgaat ataacggctt tggaatgcat gaatgatttc acctatagtt 348841 cccccaatct gttaatcaac taaaaagata gcattgaaca taaggggttg caatatgttg 348901 atcgcgtttt caaaaagttc gaattgtgta tacaaaaagc atgggtgggt gtttaaaagc 348961 gtctatgaag ggaagaggtg atgaaaaaag gaattgtcca aggatgaatg ccagacgtac 349021 caaggaaacg catgtgaaag tgaaggatgc agcagacccg tcactcatct atgccaatac 349081 cggaagaaat ggtcaagagg catgaaaccg atcttcagaa taaatttaag tcttgctgat 349141 gcccctaagg catatgatat attcgatgag aaagaaaatg gaaacattta aaccataatg 349201 gggagtcaaa tgaatattta caaaccagcc ggattttgga tcagacttgg agctgcattg 349261 ttagactaca ttatagtctc cgtgccgctt ttgctgatct attggctgat tacaggaaaa 349321 gacccaaacg acagcatgtt catcagtttg gttgttctgc tgtattctat tttgctgccg 349381 atgttttggc gcggttatct tatcggaaaa aggatctgcg gaatcagaat cgtaaaaaaa 349441 gacggatcac aggtcagtct gttaacaatg tttttacggg ttattgtagc cggcctggtt 349501 tactgtataa ccttcggact cggcttgatc gccagcctga ttctgattgc cgtacgagaa 349561 gacaaacgga ccctgcatga tttaatcgcg ggaacatatg tcacttatgc gacaccaggt 349621 gaagaggaac ttaatgctga cgaagagatt agaaagagcg aataatggtt cgctcttttt 349681 atttttatgc ataaaaaata caaggcagca aaacatatga aaaataggat tggaggaata 349741 aaatggatga aacgaataac catcaacatt atcacaatgt tcattgcagc ggctgtcatt 349801 tctctgaccg gtacagctga ggccgctgaa aaacagcagc agtctcccgc aaatgttaca 349861 ctgacagatc agcaaaagaa agagattgaa caactggaag cagagattct taaaaagcgc 349921 aaagacgtga tctcaaagta tgtacaatac ggtatcctgc ctaaagaaag aggagaacac 349981 atcaaaaatc acttggacaa acactttgaa atgatgaaac aaaacggctt tgttccaaag 350041 caccatcctc atccgcataa atttgaaaaa agacattaag attttaagca tccaatggga 350101 attgggtgct tttgcgttat ttacaggtag gcaatattag ctgagctgtt ccgcgactaa 350161 catcgagttg atatgaaacg cgtttcatag cctatgatag gtttatcaaa taattcagga 350221 gtgataaaca ctatgatcca ccagcatcca gaatcttttc cgaaacattt tttgtggggc 350281 tctgcttctg cagcgtacca gattgaaggc gcttggaatg aagatggcaa aggcccttct 350341 gtttgggatg tgtttacgaa aataccgggc aaaacgttta aaggaaccaa tggcgagatt 350401 gcggttgacc attatcaccg atttaaagaa gatgtcgctc tgatggctga gatggggtta 350461 aaagcatatc gattttccgt cagctggcca cgggtttttc caaaaggaaa aggagagatc 350521 aatgaagcag gtctagcgtt ttacgatagt ctgattgatg aattgctttc tcatcacatc 350581 gagccggttc tgactttata tcactgggat ttgcctcaag cgcttatgga cgaatacggc 350641 gggtttgaat ccagaaacat catagaggat tttaatcact actgtattac tctttataaa 350701 cgttttggag acagggtgaa atattgggtt acgttaaacg aacagaacta caattttaat 350761 cacggattta ttacagccat gcatccgcct ggagtgaaag acagaaaacg attttacgaa 350821 gcaaaccata ttgcgtttct ggctaatgca aaagccatcg aatcatttag agaatatgtg 350881 cctgaaggca aaataggtcc tagctttgct tattctccgg cttacccttt atcaagtcat 350941 ccagaggata tactggcatt tgaaaacgcc gaagaattta cgaacaattg gtggcttgac 351001 atgtattgct ggggaaccta cccgcaaatt ccattccgct gcttggaaaa acagggatgg 351061 gcgccgacaa ttgaagcagg agatatggac ctgctcgcca aagggaagcc tgattttgta 351121 ggtgtcaatt attatcagac gatcacctat gaacgaaatc cgcttgatgg tgtgtcagaa 351181 gggaaaatga atacgacagg ccaaaaggga accaatcagg agacggggat acccggagtg 351241 ttcaaaacga aaaaaaatcc gcatctgaca acgagcaact gggattggac aattgaccca 351301 attgggctgc gtatcggtct tcgccgaatt acaagccgct atcagcttcc agtgtttata 351361 acagagaacg gtttgggtga atttgataaa gttgaggacg gcactgtaca ggatgattat 351421 cgaattgatt atttgcgttc gcatcttgag caatgcagac aagccatcag tgacggtgtc 351481 gatttaatcg gctattgcag ctggtcgttt actgatctgt taagctggct gaacggctac 351541 caaaaaagat acggatttgt atatgtcaat cgtgatgaag aaagcacatc cgatttaaaa 351601 cgcttgaaga aaaaaagctt ttattggtat caagatgtca tcaagacaaa cggagaaagt 351661 ttataaagag tccctgagag ttattctctc aggggttttt cattacacag aaacagcatc 351721 aataatataa gtgtcggcgt gcaaatctga catttcagcc ggcacagtcc agcatgtcaa 351781 ttgatagtct cctttaggca gatcaaagga cagtctttta gacatgatgc tttcaatatg 351841 aattccgttt tctgtgacat gaaaaggaac agtcactttt ttttcgtagg agtttactgt 351901 ttctgaactg ttcaggcgaa aaagaataaa ggcctttgta tttcgctgtg cctcaaagga 351961 aatggctccg tctgccgcag catatccttt ttcaatcgct tcgtcagtcc aatccattac 352021 aggaggtgta gaatcctttt gaaatacagt aaattgatga tatgaaatcg aaagttcttg 352081 cggcttccat gatttgatca atgtgctgtt cctcctctat gtactgttta ctgaattgtg 352141 aataaaacct ttgtgccgtc tgggtaatcg gtaagccgat gcccgaccca agagcctgct 352201 ccgcggttgt cagcgggaga aatgtattct acagaagctc cctcaccgcc ttctttgcac 352261 atggccattg gccattcatc tctgtcatac ccctttttgg aaggtacgtc ctttaatgat 352321 tgctcgcggc gttcttcagc tccgtctctg tcaatagtgc acacctctga gtgcccctca 352381 tttatcgcat ccttaatatg cttggcagtt tcgggatacc ggtcagatgg gaaggccatt 352441 gtttcatcat attctttcgt ttgagacgtt ttttgatcag ctgagaaaaa gtctcctttt 352501 atcaggccga cagctgcagc tgctatgatg acgatgacga gaagtatcgt ttttatgatg 352561 tccgtcgtga tgttcacctc ccgcttttaa aactgacaca agagtaatcc agaaagcatt 352621 tggtgtaaag gtttaaattt tatgttttac gatcagttta ttgcagaaat cgtaatttta 352681 gcagatcgaa atatttgttt tcagcaaaat acgattgcca atttacaata atgatagtaa 352741 gtcatcagcc gttttcggct tgattaatca ttttaaattg gcttatgata ccggtaagct 352801 cctcagctaa ttgagaaagt gtttcagaag ctgcggtaat ctcctccatt gcagcaaatt 352861 gctcctctgt taatgcagcc gcttgccggg tatttttagt agattcttta atgtcggccg 352921 tattggctgc aaaggaatca tttatttgat gtgcactggc tgaaatgttt gttacagatg 352981 ctgataaatc actaatctcg gcgctgattt cacctgttgc agctgcaatt tccttaaatg 353041 catctctggt gcgctggatc atggtgactc cttctgcagc ttctgttttc acatgctcaa 353101 cagatcttgc agaccggttc atatcctttt gtatttctat gatcagtttt gaaatctgcc 353161 ccgcagactg ttgagactct tctgctaatt tccgtacttc atcagcaaca acagcaaagc 353221 cttttccttg ttcaccggct ctggcagctt caatcgctgc attcagcgca agcaggtttg 353281 tctgatcagc aatttgggtg atgaccgata aaatttgctc aatttgttta gagcggccgt 353341 ctaactggtg tatgatttct ccgcttttct gaattgactg gtgaatcgca tccatttgcg 353401 cctgtacatt tgcaatttcc ttttgtccaa tgtctgcttt tgattgagcg agctgccctt 353461 tgtcagcgat agcggcagta tttgcagaaa tatcccggat gtctgctgaa gcttgtttta 353521 atgagctttc actattttca attcgggtga tctgatcttg ggctccattt gcaatctgct 353581 gtacagcttc tgtgattttt tctgaagctt gatttgtttc ctctgctccg gctgagagct 353641 gctgagaggc tgacgcaagc tgaagggctg attgttgtac ggtttgtatg gtatcgttca 353701 gcttcattct catcttatta taatagacgc ttagttctga aagctcgtca ccggttttgt 353761 ctgacacctc tattgtcata tctccgtttc cggcactttc aaaggcgctt tttaaagcgt 353821 tcagccgctt gttgattttt ctggtgaaaa ccaagacaag gatgactgat accataatga 353881 cgataacaag aacgatagcg aattgagtga aaagtgattg tgtaagtgat gctaaaatac 353941 tttgattagc tccggtatac agcatgccga tgatgttccc attttgatct tttaacggca 354001 tgtatgcagt ctgataagaa gaacctgcta catctgcttg tccgtaaaaa cgctttcctt 354061 tctttaaaac agcggcaata acttcagaag aagcctgggt gccgacggct ctttcgccat 354121 ttttcatgac attggttgca acacgagtat cgccttggaa aatggtaatg gtatcacctg 354181 tcttttcacc aagcagatca acaatatctt catttccatt gatttgtgtt tgccctttat 354241 agagcttatt gtttttcacc tgccagtcgc ctgacatgac atcatcaata taagtgctgc 354301 ttaaagcgag atcacctttc gctttttcag ttgccatttg tttcatgctt tctgtaattt 354361 ccttaagcat cacagtgcca actgatgccg aaaacaaaag aatcaccacg aaaacgaggc 354421 aaagaatttt agttcctagc ttcatcttaa atcgttttat caacataatt cctcccttta 354481 cgatttgcag gtcatattac ttatcgggtt tttgggttta aagttttatt ttagaaaaaa 354541 taaaaccggc ctgatcttca ggccggttgt gtgatgctat tcaaggtttg cgtggtgagt 354601 gaacatagtt tcagaatcga gacctttttt ctccatgagt tttaaaatca ctgcatcata 354661 gaagagcagc aaagtttgtt caaataatga tcccattggc tgaatggttt tatagcttcc 354721 gttagactgg tctttagggg aaccaggcat tctgatgatg aggtccgctt gttttccgat 354781 gcttgattcc ggattgatgg ttaaagcggc aacaattccg tgtaagcttt ttgcttttgc 354841 tgcggtatga atcaagctct ttgtctcgcc tgatcctgag ccgataataa ctagatctcc 354901 ttcggcgagc ggcggagtga gaatctcacc tactatatgg gcgttgaagc ccatgtgcat 354961 cagtctcatc gcgaaggatt ttgccatcag gccagaccgc cccgcacccg cggtgaaaat 355021 ttggtgggat gaaagaatgt gatcggcaag ctggtcagct tcttcattag aaatataagc 355081 tgctgaattg tgtaactcat tgagaatttc cgctacgtat tcagtcgttt tcatcggagt 355141 tatccttgga caatcagctg cttcattttt gaagctgttt ccgccttatc agctgcgctt 355201 gtaattccgc ccccgacaat gacaaggtca ggcttttgct ggatcacttc tggcagtgta 355261 tcaagtttga tgccgcccgc gattgcggtt tttgcgtttt ttacggtatt tttgattgtc 355321 gttaattctt cgaaagagtt tttgccctct gcttgaagat catagccagt gtggacgcag 355381 atgtagtcaa caccgagtgc gtcaatttct ttcgcacggg attcgatatc tttcacgtta 355441 atcatgtcca ctaagatttt cttcttttgt tttttggctt cttctactgc gcctttaatc 355501 gttgcatcgt ctgtagcccc taaaacggtg atgatgtcag cgcctgcttc cgacgctttc 355561 ataatttcgt agcctccggc atccatgatt ttcaggtctg caagaacctt caattgagga 355621 aatgcttctt ttatttcttt aacggctctt aggccttcat tgatgacgac cggtgttccg 355681 atttcaacta cgtcgatgta ttgttctacc tctttgacaa gctcaatggc ttccgggatg 355741 ttgacgaggt ctaatgcaag ctgtaattcc attgttgatc cactcccttt ttcgaattat 355801 tgttcattct ataggttcct tcttttgttg agaagtaggc actttgaagt caacaagtta 355861 cttggaggat actgtgagga gagacaatca gatttctttc gcttgatttt atgagtgagt 355921 ataatgaaaa aagagtctgc aaaaaagtaa gtaagtgatg atacgtatct aacatacaaa 355981 aaggttacta agggggggga ttctattgag ccggatggac gacaaaaggt ttaattgtga 356041 gaaggaatta acgcttgcag tgattggcgg taaatggaaa atgctcattt tatggcattt 356101 aggaaaagaa ggcacaaaac ggttcaatga attaaaaaca ttgattcctg atattacgca 356161 gaagatcctc gtgaatcagc tgagagagct tgagcaggat atgattgttc acagggaagt 356221 gtatccagtt gtcccgccga aggttgaata ttctctgacc ccgcacggag aaagcctcat 356281 gcctattctt gaagccatgt atgagtgggg gaaaggctat atggaattga ttgatatcga 356341 caaaaatgtc atgaaagaat cgttgtaaga cgctcttcgc aagggtgtct ttttttgcct 356401 ttttttcggt ttttgcgcgg tacacatagt catgtaaaga ttgtaaattg cattcagcaa 356461 taaaaaaaga ttgaacgcag cagtttggtt taaaaatttt tatttttctg taaataatgt 356521 ttagtggaaa tgattgcggc atcccgcaaa aaatattgct gtaaataaac tggaatcttt 356581 cggcatcccg catgaaactt ttcacccatt tttcggtgat aaaaacattt ttttcattta 356641 aactgaacgg tagaaagata aaaaatattg aaaacaatga ataaatagcc aaaattggtt 356701 tcttattagg gtggggtctt gcggtcttta tccgcttatg ttaaacgccg caatgctgac 356761 tgacggcagc ctgctttaat agcggccatc tgttttttga ttggaagcac tgctttttaa 356821 gtgtagtact ttgggctatt tcggctgtta gttcataaga attaaaagct gatatggata 356881 agaaagagaa aatgcgttgc acatgttcac tgcttataaa gattagggga ggtatgacaa 356941 tatggaaata actttttacc ctttaacgga tgcacaaaaa cgaatttggt acacagaaaa 357001 attttatcct cacacgagca tttcaaatct tgcggggatt ggtaagctgg tttcagctga 357061 tgcgattgat tatgtgcttg ttgagcaggc gattcaagag tttattcgca gaaatgacgc 357121 catgcgcctt cggttgcggc tagatgaaaa cggggagcct gttcaatata ttagcgagta 357181 tcggcctgtt gatataaaac atactgacac tactgaagat ccgaatgcga tagagtttat 357241 ttcacaatgg agccgggagg aaacgaagaa acctttgccg ctatacgatt gtgatttgtt 357301 ccgtttttcc ttgttcacca taaaggaaaa tgaagtgtgg ttttacgcaa atgttcatca 357361 cgtgatttct gatggtatct ccatgaatat tctcgggaat gcgatcatgc acatttattt 357421 agaattagcc agcggctcag agacaaaaga aggaatctcg cattcattta tcgatcatgt 357481 tttatctgaa caggaatatg ctcaatcgaa gcggtttgaa aaggacaagg cgttttggaa 357541 caaacaattt gaatcggtgc ctgaacttgt ttccttgaaa cggaatgcat ccgcaggggg 357601 aagtttagat gctgagaggt tctctaaaga tgtgcctgaa gcgcttcatc agcagattct 357661 gtcgttttgt gaggcgaata aagtcagtgt tctttcggta tttcaatcgc tgctcgccgc 357721 ctatttgtac agggtcagcg gccagaatga tgttgtgacg ggaacattta tgggcaaccg 357781 gacaaatgcg aaagagaagc agatgcttgg catgtttgtt tctacggttc cgcttcggac 357841 aaacattgac ggcgggcagg cgttttcaga atttgtcaaa gaccggatga aggatctgat 357901 gaagacactt cgccaccaaa agtatccgta taatctccta atcaacgatt tgcgtgaaac 357961 aaagagctct ctgaccaagc tgttcacggt ttctcttgaa tatcaagtga tgcagtggca 358021 gaaagaagag gatcttgcct ttttgactga gccgattttc agcggcagcg gattaaatga 358081 tgtctcaatt catgtaaagg atcgatggga tactgggaaa ctcaccatag attttgatta 358141 ccgcactgat ttattttcac gtgaagaaat caacatgatt tgtgagcgca tgattaccat 358201 gctggagaac gcgttaacgc atccagaaca tacaattgat gaattaacac tgatttctga 358261 tgcggagaaa gagaagctgc ttgcgagggc cggcggtaaa tctgtgagct accgtaagga 358321 catgacgata ccagagctgt tccaagaaaa ggctgaactg ctttctgatc atccagcggt 358381 tgtatttgaa gatcgcacat tgtcctatcg aacgttacat gagcaatctg cacgcatcgc 358441 caatgtgctg aaacagaaag gggttggccc ggacagtcct gtcgcggttt tgattgaacg 358501 ctctgaacgg atgattacag ctatcatggg aattttaaaa gccggcggag cctatgtgcc 358561 gattgatccg ggttttcctg ctgagcgcat tcaatatatt ttggaggact gcggggcgga 358621 tttcatcctg actgaatcga aggttgcggc gcctgaagcc gatgctgagc tgattgactt 358681 agatcaggcg attgaggaag gtgcagaaga aagcctgaat gcagatgtga acgctcggaa 358741 ccttgcctac attatttaca catcgggaac aaccggacgc ccgaaaggcg ttatgatcga 358801 gcatcgccag gttcatcatt tggttgaatc tctgcagcag acgatttatc aaagcggcag 358861 ccaaaccctg cggatggcat tgcttgcgcc gttccacttt gatgcgtcag tgaagcagat 358921 cttcgcgtcg cttcttttgg gccaaaccct ttatatcgta ccgaagaaaa cagtgacgaa 358981 cggggccgcc cttactgcat attatcggaa gaacagcatt gaggcgacgg acggaacacc 359041 ggctcatttg caaatgctgg cagcagcagg cgattttgaa ggcctaaaac tgaagcacat 359101 gctgatcgga ggagaaggcc tgtcatctgt tgttgcggac aagctgctga agctgtttaa 359161 agaagccggc acagcgccgc gtttgactaa tgtgtacggg ccgactgaaa cgtgcgttga 359221 cgcgtctgtt catccggtta tccctgagaa tgcagttcaa tcagcgtatg tgccgatcgg 359281 gaaagcgctg gggaataacc gcttatatat tttggatcaa aaaggccggc tgcagcctga 359341 aggcgtggcg ggtgagcttt atatcgcggg agacggtgtg ggccgaggct atttacattt 359401 gcctgaatta acggaagaga agtttttaca agatccattc gtgccgggcg atcgcatgta 359461 ccggaccggg gacgtggtgc gctggcttcc agatggaaca atcgaatatt taggcagaga 359521 ggatgaccag gtcaaagtcc gcggataccg gattgagctt ggggaaattg aagccgtgat 359581 tcagcaggcg ccagacgttg caaaagccgt tgttttggca cgccctgacg aacagggaaa 359641 tcttgaggtt tgcgcatatg ttgtgcagaa gcctggaagc gaatttgcgc cagccggttt 359701 gagggagcat gcggccagac agcttcctga ctatatggtg ccggcttact ttacagaagt 359761 gacagaaatt ccgcttacac caagcggcaa agtcgaccgc cgcaagctgt ttgcactaga 359821 ggtgaaggct gtcagcggca ctgcctatac agcgccgcga aatgagactg aaaaagcaat 359881 cgcagccatt tggcaggacg tgctgaacgt tgagaaggcg gggatctttg acaatttctt 359941 tgaaactggc ggacattcat taaaagccat gaccctttta acaaagattc ataaggaaac 360001 aggcattgag attccgcttc aatttttgtt tgagcatccg acgattacgg ctcttgcaga 360061 ggaagctgat cacagagaaa gcaaagcttt tgcggtgatt gaacctgctg aaaaacagga 360121 gcattacccg ctttcattgg cacagcagcg aacatatatc gtcagccagt tcgaggatgc 360181 gggagtcggc tataacatgc cagcagcagc aattctggaa gggcctttag atattcaaaa 360241 gctggagcgc gcatttcagg gattaatccg acgccacgag tcattgagaa catcatttgt 360301 tcttgaaaac agcacgccga gacagaaaat tcacgatagc gttgatttca acatcgaaat 360361 gattgaaaga ggcggccgct cagatgaggc aattatggct tcattcgttc ggacatttga 360421 tttggcgaaa gctccgctgt tcagaatcgg tttgctgggg cttgaagaga accgtcatat 360481 gctgctgttt gacatgcacc atttgatttc tgacggtgta tccattggca ttatgctgga 360541 ggagttagca cgcatttata aaggcgaaca gcttcctgat cttcgtctcc agtataagga 360601 ctacgctgta tggcaaagca gacaggctgc tgaagggtac aagaaggacc aggcttattg 360661 gaaggaagtc tttgcaggcg agctcccggt gcttcagctt ctgtccgatt acccaagacc 360721 acctgttcaa agctttgaag gggatcgggt gtcaatcaag ctggatgcgg gggtaaagga 360781 tcgcctcaat cgtttggctg aacaaaacgg cgccacttta tatatggtga tgctttccgc 360841 ttactatacg cttttgtcaa agtatacggg gcaggatgac atcattgtcg ggacaccgtc 360901 agcgggcaga aatcactccg atacagaggg cattatcggg atgttcgtca atacgcttgc 360961 gattcgcagt gaggtgaagc agaatgagac gtttacccaa ttgatctcgc gtgtccgcaa 361021 acgggtgctg gatgcctttt ctcatcagga ctatccgttt gagtggcttg ttgaagattt 361081 gaacatcccg cgtgatgtta gcaggcatcc gctgtttgac acgatgttca gccttcaaaa 361141 cgcgacagag ggcattccgg ctgtcggcga tctttccttg tctgttcaag agaccaattt 361201 caagattgcc aaatttgatt tgacggtgca ggcgagagaa accgatgaag gcattgagat 361261 tgatgtggat tacagcacaa agctgtttaa acaaagcacg gcagacaggc tgcttacgca 361321 ttttgcgcgt ttgcttgaag atgctgcggc tgatccagag aagccgattt ctgagtataa 361381 gcttctttct gaagaggagg ctgcttcgca aattcagcag tttaacccgg gcagaacacc 361441 ttatccgaaa gataaaacaa ttgttcagct gtttgaggag caagcggcga atacgccaga 361501 ccacactgcg cttcaatatg aaggcgaatc actcacttat cgtgaactga atgaacgggc 361561 caatcgttta gcccgcggca ttctttctct tggagctggc gaaggcagaa ctgcggctgt 361621 cttatgcgag cggtcaatgg atatgattgt gtcgatcttg gcagtattaa aatcaggttc 361681 ggcttatgtt ccgatcgatc cggaacatcc gattcagcgg atgcagcatt tcttccgtga 361741 cagcggagca aaggtgcttc tcactcagag gaaattaaag gctttggcgg aagaagcgga 361801 atttaagggc gttatcgtgc tagccgatga ggaagaaagc tatcatgccg atgcgcgaaa 361861 tctcgcactg cctcttgatt ctgcagcaat ggccaacctg acgtatactt ccggaacgac 361921 tggaacacct aaggggaata tcgtgacaca tgccaatatt ctccgcacgg tgaaggaaac 361981 gaattatctc agcattacag aacaggatac gattctcggt ctttccaatt acgtgtttga 362041 cgcgtttatg ttcgatatgt tcggctcttt gttaaacgga gccaagctgg tgctgatacc 362101 gaaggaaacc gttttggaca tggctcgcct gtcccgcgtc attgaacggg agaacatcag 362161 cattctcatg attacaaccg ctttgttcca cttgcttgtg gacttgaatc cggcatgctt 362221 gtcaacgctt cgcaagatta tgtttggcgg ggaacgggct tcggttgagc atgtcagaaa 362281 agctttgcaa acggttggaa agggcaagct ccttcatatg tatggaccgt ctgaaagcac 362341 ggttttcgcg acgtatcatc cggttgatga attggaggag cacacgctgt ctgttccgat 362401 tggaaaaccg gtcagcaata cggaagtata cattcttgac cgtacgggac acgtgcagcc 362461 tgccgggatt gccggagagc tttgcgtcag cggcgaagga ctcgtgaaag gctattacaa 362521 ccgtccagaa ctgactgagg agaaatttgt tccccatccg tttacatccg gcgaacgcat 362581 gtataaaacg ggagaccttg cgagatggct gccgaatggc gacatcgaat ttatcgggcg 362641 aatcgaccat caggtgaaga ttcgcggaca gcgcatcgag cttggagaaa tcgaacatca 362701 gctgcaaacc catgatcgtg ttcaggaaag tgttgtgctt gccgttgatc aaggagcggg 362761 agataaactg ttgtgtgctt actatgtcgg agaaggagac atctcatcac aagagatgag 362821 agagcatgct gcgaaggact tgccggcata tatggttcct gcggtgttta tccaaatgga 362881 cgagctgccg ctgacaggga acggaaaaat tgaccggaga gcgctgccga ttcctgatgc 362941 caacgtttca agaggtgttt catatgttgc gccacgcaat ggaacggaac aaaaagtcgc 363001 ggacatttgg gcacaggtac ttcaggcaga acaagtcggc gcttatgacc acttctttga 363061 cattggcgga cattcattag caggcatgaa gatgcttgcc ttggttcatc aggaactggg 363121 cgttgagctg tcactcaagg atctcttcca gtcaccgacg gttgagggct tggcacaggt 363181 gattgcctct gctgaaaaag ggacagccgc aagtatcagc ccggcagaga aacaagatac 363241 gtatcctgtt tcttcaccgc aaaaacggat gtacgtgctt cagcagcttg aggatgcgca 363301 aacgagctat aacatgccgg cggttctgcg cctgacaggt gagcttgatg ttgaaaggct 363361 taacagcgtc atgcagcagt taatgcagcg tcatgaagcc ttgagaacca cgtttgaaat 363421 aaaagatgga gaaacggtgc agcggatctg ggaagaggct gagtgcgaga tagcctattt 363481 cgaagccccg gaagaagaga cagagcggat cgtttctgag tttattaagc ctttcaaaat 363541 cgaccaactt ccactgttca gaatagggct tatcaagcat tcagacactg agcatgtgct 363601 gctgttcgat atgcatcata ttatttctga tggtgcatct gtcggtgtgc tgattgagga 363661 gctttcaaag ctgtacgacg gagaaaccct tgagccgctc cgtattcaat ataaggatta 363721 tgccgtgtgg cagcagcagt tcattcagtc tgagctttac aagaagcaag aagagcattg 363781 gctgaaggag ctggacggag agctgccggt gctgacgctt ccgactgatt acagtcggcc 363841 tgccgttcaa acatttgagg gagaccgcat tgcattttca ttagaagcag gcaaagctga 363901 tgctctgcgc aggcttgcaa aagaaacgga ttccacgctt tacatggtgc ttctggcttc 363961 atacagtgcg tttttatcaa aaattagcgg gcaagacgat atcatcgtcg gttcacctgt 364021 ggccggacga tctcaagcgg acgtcagccg cgtcatcgga atgttcgtca atacattggc 364081 gctgcgcacg tatccgaagg gtgaaaagac gtttgctgac tatcttaacg aagtgaaaga 364141 aacggcactc agcgcttttg atgcgcagga ttacccactt gaggatttga tcggaaatgt 364201 tcaggttcag cgtgacacaa gcagaaatcc gttattcgat gcagtttttt caatgcaaaa 364261 tgcgaatata aaggatttaa caatgaaagg gattcagctt gagccgcatc cgtttgaacg 364321 gaaaacagcc aagtttgacc tcacgctgac ggctgacgaa accgacggag ggcttacatt 364381 cgtactcgaa tacaatacag ctctgtttaa gcaggaaacg attgaacgat ggaagcaata 364441 ttggatggag cttttagatg cagttactgg gaacccgaac cagccgcttt ccagcctgtc 364501 actggtcacc gagacagaaa agcaagcgct tcttgaggca tggaagggca aagcgctgcc 364561 tgtgccgaca gacaaaacgg ttcatcagct attcgaagag actgcccagc gccacaaaga 364621 ccgcccggct gtcacataca acggccagtc ttggacgtac ggcgagctga atgcgaaggc 364681 aaaccgtctc gcgcggattc tgatggactg cggcatcagc ccggatgacc gcgtcggcgt 364741 tctcacgaag ccgtcgcttg aaatgtccgc cgcggtgctc ggcgtcttga aagccggagc 364801 ggcgtttgtg ccgattgatc ctgactatcc ggatcagcgg attgagtata ttttacagga 364861 cagcggcgcg aagcttctct tgaaacagga aggcatttca gtgccggaca gctatacggg 364921 agatgtcatt cttctcgacg gaagccgcac gattctaagc ctgccgcttg atgaaaacga 364981 cgaggaaaat ccagaaaccg ctgtaaccgc ggagaacttg gcgtacatga tttacacgtc 365041 tggaacgacc ggacagccga agggtgtcat ggtcgagcac catgcgcttg tgaacctgtg 365101 cttctggcac cacgacgcgt tcagcatgac agcggaggac cgcagtgcga agtacgcggg 365161 ctttgggttc gacgcttcca tttgggagat gttcccgacc tggacgatcg gtgccgaact 365221 tcacgtcatt gaggaagcga tccgcctcga tatcgtccgc ctgaacgatt attttgaaac 365281 gaacggcgta acgatcacgt tcctgccgac acagcttgcg gaacagttca tggagcttga 365341 gaacacatca cttcgcgtat tgcttactgg aggagacaag ctgaagcgcg cagtgaaaaa 365401 gccgtacaca ctcgtcaata actacgggcc gacagagaat acggtcgttg ccacaagcgc 365461 agaaatccat ccggaggaag gctcgctttc catcggaagg gccattgcca atacgagagt 365521 atacattctc ggcgagggca atcaggtgca gccggaaggc gtagccggag agctttgcgt 365581 ggcggggcgc ggactggcac gcggctatct gaatcgagaa gacgaaaccg cgaagcggtt 365641 tgtcgctgat ccgtttgtgc cgggtgagcg catgtaccgc accggcgatt tggtgaaatg 365701 gacgggcggc ggcatcgaat acatcggccg gatcgaccag caggtcaagg tccgcggcta 365761 ccggatcgag ctctcagaaa ttgaagtcca gctcgcccag ctttctgagg tgcaggatgc 365821 ggcggtgaca gctgtcaaag ataaaggcgg caacacagcg atcgcggcgt atgtcacacc 365881 ggaatcagct gacatagaag cactgaaatc agcactgaag gaaaccctgc cggattacat 365941 gatcccggcg ttctgggtga cgctgaacga gcttccggtt acggcaaacg gcaaagtgga 366001 ccgcaaagcc ttgcctgagc cggacatcga agcgggaagc ggagaataca aagcgccgac 366061 gaccgacatg gaagagctgc ttgccggcat ctggcaggac gtgcttggaa tgtctgaagt 366121 cggtgtcacc gacaatttct tctcgcttgg cggagattcc atcaaaggaa ttcaaatggc 366181 gagccgcttg aaccagcacg gctggaagct ggaaatgaaa gatctcttcc agcacccgac 366241 gatcgaagag ctcacccagt acgtagagcg tgccgaaggc aaacaggcag accaaggccc 366301 ggtggagggc gaagtcatcc tgacgccgat ccagcgctgg ttctttgaaa agaacttcac 366361 gaacaagcac cactggaacc aatctgtgat gcttcacgcc aagaagggct ttgatcctga 366421 acgggtggag aaaacattgc aggcgctgat cgagcatcat gacgcgctcc gcatggtcta 366481 tcgtgaggga caggaagacg tcattcaata caacagaggt cttgaagctg cttcagctca 366541 attggaggtc atccagattg agggccaagc tgcagattac gaagaccgaa tagagagaga 366601 agcggagcgt ttgcaaagca gcatcgactt gcaggaaggc ggcttgttaa aagcaggctt 366661 gttccaagcg gaagacggag atcacttgct tcttgccatt caccacttag tggttgacgg 366721 cgtgtcgtgg cggattttac tggaggattt cgccgcggta tatacacagc ttgagcaagg 366781 caatgaaccg gttctcccgc agaaaacaca ttcatttgca gagtatgcag agagattgca 366841 agacttcgcg aactccaaag cctttttgaa agaaaaagag tattggagac agcttgaaga 366901 acaagctgtt gcggcaaagc ttccgaaaga ccgcgaatct ggtgatcagc gaatgaaaca 366961 tacaaagaca attgaattct cgctgactgc tgaagagaca gaacagctca ccacaaaggt 367021 gcatgaggca tatcacacag aaatgaatga tattttgctg acggcattcg gattggcaat 367081 gaaggagtgg acgggtcaag atcgagtaag tgttcattta gaggggcatg gacgtgaaga 367141 aatcatagaa gacctgacca tttctcgcac agtcggctgg tttacaagta tgtacccaat 367201 ggtgctcgat atgaagcatg cggatgatct gggctaccag ctgaagcaaa tgaaagaaga 367261 tatcagacat gtgccgaata agggagtcgg atacggcatt ctgcgctatc tgacggcacc 367321 ggaacataaa gaagatgtgg cgttctcgat tcagccggat gtcagcttca actatttagg 367381 tcagtttgac gaaatgtcgg atgcaggttt gtttacgaga tcagagctgc catcaggaca 367441 gtcattaagc cctgaaacag aaaaaccgaa tgcgctggat gttgtcggat atatcgaaaa 367501 cggaaaactg acgatgtcac tggcctatca ttctcttgaa tttcatgaaa aaacagtaca 367561 aacattcagt gacagcttta aagcgcatct tctcagaatc attgaacatt gcctatctca 367621 agatggtacg gaactgaccc cgagtgatct tggtgacgac gatttgacgc tggatgagct 367681 ggataaatta atggaaattt tctaatagag gtggcatatg agcaaaaaat cgattcaaaa 367741 ggtgtacgca ctgacaccaa tgcaggaggg aatgctgtat catgcgatgc ttgatccgca 367801 ttcttcctcg tacttcacac aattagagct tgggattcac ggcgcttttg atcttgaaat 367861 ctttgagaaa agcgtcaatg aactgattcg gtcatacgat attctccgta cggtatttgt 367921 gcatcagcag ctgcaaaaac cgcgtcaggt cgtgttagcg gaacgcaaaa caaaagtgca 367981 ttatgaggat atcagtcatg cagacgaaaa ccgccagaaa gagcacattg agcgttacaa 368041 acaagacgtt cagcgccaag gctttaacct ggcaaaagac atattgttca aggtagcggt 368101 tttccgcctt gctgcagatc agctgtatct tgtctggagc aatcatcata ttatgatgga 368161 cggctggagc atgggcgtcc tcatgaaaag cctgttccaa aactatgaag cgctcagagc 368221 aggcaggaca ccggcaaacg gtcagggcaa gccttattcc gattacatca agtggcttgg 368281 aaaacaggac aatgaagaag cggagagcta ctggagcgag cgcttggcgg gttttgaaca 368341 gccaagcgtg ctcccgggcc gcctgcctgt gaaaaaagac gaatacgtca ataaagaata 368401 ttcatttaca tgggacgaaa cactggttgc ccgtattcag caaaccgcaa atctccatca 368461 agtgacaggg cctaacctat ttcaggccgt ttggggcatt gttctcagca aatacaactt 368521 tacggatgat gtgatcttcg gaacggtcgt ctcgggacga ccgtctgaaa tcaacggaat 368581 cgaaacgatg gcggggctgt ttatcaacac cattccagtg cgggtgaaag ttgaacgaga 368641 tgctgcattc gctgatattt tcacagctgt tcagcagcat gcagtagagg cagagcgtta 368701 cgattacgtg ccgctctatg agattcaaaa acgctcagct cttgatggca atctcttaaa 368761 ccatctggtc gcgtttgaaa attatccgct tgatcaagag cttgaaaacg gcagcatgga 368821 agaccgcctc gggttttcga ttaaggtaga aagcgcattt gaacaaacga gcttcgattt 368881 caacctgatt gtgtatccgg gcaaaacgtg gaccgtcaaa attaaatata acggagccgc 368941 ctttgattcc gcttttatcg aacggacagc ggagcacctt acccgcatga tggaagcagc 369001 tgtcgatcag ccggccgctt ttgtgcgtga gtacgggctt gtgggagacg aagagcagcg 369061 gcaaattgtc gaggtgttta acagcacgaa agccgaactc cctgaaggaa tggctgttca 369121 ccaagtgttt gaagagcaag cgaaacggac gccggcgagc accgccgtcg tatatgaagg 369181 aaccaagctg acgtaccgcg agctgaatgc agcggctaac cgtctggcga gaaagcttgt 369241 cgaacatggg cttcaaaaag gggaaacagc agcgattatg aacgaccgct cagtagaaac 369301 cgttgtcggc atgctggctg ttttaaaagc aggcgccgca tatgtgccgc ttgatccagc 369361 gcttcctggg gatcgtcttc gtttcatggc agaggacagc tccgttcgaa tggttttgat 369421 cggaaattct tatacagggc aggcacatca gctgcaagtg ccggttctta cactggacat 369481 aggctttgaa gagagtgaag cggctgacaa tctcaacctg ccatccgccc cgtctgattt 369541 ggcgtacatc atgtacacat ccggttcaac gggcaaaccg aaaggcgtca tgatcgaaca 369601 taaaagcatt ctgcgcctcg tcaaaaatgc cgggtacgtt cctgttactg aagaagaccg 369661 catggcgcaa acgggagctg tcagctttga tgccggaacg tttgaggtat tcggcgcact 369721 gctgaatggc gcagcacttt atccggtcaa aaaagagaca ctgcttgatg cgaaacaatt 369781 tgctgcattc ctgcgtgagc aaagcatcac aactatgtgg ctgacatcac ctttattcaa 369841 ccagcttgct gcaaaggatg cgggtatgtt cggcacactg cgccatttaa tcatcggcgg 369901 agatgccctt gtcccgcata ttgtcagcaa agtaaaacag gcatcgccgt cgctttcatt 369961 gtggaacgga tacggcccga cagaaaacac gacgttttca accagttttc tgatcgaccg 370021 cgagtatggc ggctctatcc caatcgggaa gccgatcgga aattccactg cctatattat 370081 ggatgagcag caatgcctgc agccaatcgg cgcgcctggt gagctttgcg taggcggaat 370141 cggtgtagcg cgtgggtatg tcaatctccc tgagctgacg gagaagcaat ttctggaaga 370201 cccgttcaga ccgggtgaga gaatttaccg cactggtgac ttggcaagat ggctgccgga 370261 cggcaatatc gaatttttag gcagaatcga caaccaagtg aaggtgcgcg gcttccgaat 370321 tgagcttggc gaaattgaaa caaaactgaa catggctgag catgtgacag aagccgcggt 370381 gatcatacgc aagaacaaag cagacgaaaa tgaaatttgc gcgtacttca cggcggatcg 370441 tgaagtggct gtgagtgagc tgagaaaaac actgtctcag tctttgcctg actatatggt 370501 ccctgcccac ctgattcaaa tggacagcct gccgctcacg ccaaacggga aaatcaacaa 370561 aaaggaactg cctgcaccgc aatcagaagc cgtgcagccg gaatacgcag caccaaaaac 370621 agagagtgaa aagaaattag cggagatctg ggaaggaata ctcggcgtca aagcaggcgt 370681 taccgataac ttctttatga tcggcggcca ttctttgaaa gcgatgatga tgacggcgaa 370741 aattcaagag cattttcata aggaagttcc gataaaagtg ctttttgaaa agccgactat 370801 tcaagaactg gcactgtatt tggaagagaa cgaaagcaag gaggagcaga cgtttgaacc 370861 gatcaggcaa gcatcttatc agcagcatta tcctgtatcc ccggcccagc ggagaatgta 370921 tatcctcaat cagcttggac aagcaaacac aagctacaac gtccccgctg tacttctgct 370981 ggagggagaa gtagataaag accggcttga aaacgcgatt cagcaattaa tcaaccggca 371041 cgaaatcctc cgtacatcgt ttgacatgat cgacggagag gttgtgcaaa ccgttcataa 371101 aaacatatcg ttccagctgg aggctgccaa gggacgggaa gaagacgcgg aagagataat 371161 caaagcattt gttcagccgt ttgaattaaa ccgcgcgccg ctcgtccgtt cgaagcttgt 371221 ccagctggaa gaaaaacgcc acctgctgct cattgatatg catcatatta ttactgacgg 371281 aagttcaaca ggcattctaa tcggtgatct tgccaaaata tatcaaggcg cagatctgga 371341 actgccacaa attcactata aagattacgc agtttggcac aaagaacaaa ctaattatca 371401 aaaagatgag gaatactggc tcgatgtctt taaaggcgaa ctgccaatac tggatcttcc 371461 cgcggatttc gagcggccag ctgaacggag ctttgcggga gagcgcgtga tgtttgggct 371521 tgataagcaa atcacggctc aaatcaaatc gctcatggca gaaacagata cgacaatgta 371581 catgtttttg ctggcggcgt tcaatgtact cctttccaag tacgcgtcac aggatgatat 371641 cattgtcggc tcgccgacag ctggcagaac acatcctgat ctgcaaggtg tgccgggtat 371701 gtttgtcaac acggtggcac tcagaacggc accagcggga gataaaacct tcgcgcaatt 371761 ccttgaagag gtcaaaacag ccagccttca agcattcgag caccagagct atccgcttga 371821 ggagctgatt gaaaagcttc cgcttacaag ggatacaagc agaagtccgc tgttcagcgt 371881 gatgttcaac atgcagaata tggagattcc ttcattaaga ttaggagatt tgaagatttc 371941 ctcgtattcc atgcttcatc atgttgcgaa atttgatctt tccttggaag cggtcgagcg 372001 tgaagaggat atcggcctaa gctttgacta tgcgactgcc ttgtttaagg acgagacgat 372061 ccgccgctgg agccgccact ttgtcaatat catcaaagcg gccgcggcta atccgaacgt 372121 tcggctgtct gatgtagatc tgctttcatc tgcagaaacg gctgctttgc tagaagaaag 372181 acatatgact caaattaccg aagcaacctt tgcagcactt tttgaaaaac aggcccagca 372241 aacacctgac cattctgcgg tgaaggctgg cggaaatctg ttgacctatc gcgagcttga 372301 tgaacaggcg aaccagctgg cgcatcatct tcgtgcccaa ggggcaggaa atgaagacat 372361 cgtcgcgatt gttatggacc ggtcagctga agtcatggta tccattctcg gtgtcatgaa 372421 ggcgggggca gctttccttc cgattgatcc tgatacacct gaagaacgaa tccgttattc 372481 attagaggac agcggagcaa aatttgcggt cgtgaatgaa agaaacatga cggctattgg 372541 gcaatatgaa gggataattg tcagccttga tgacggtaaa tggagaaatg aaagcaagga 372601 gcgcccatca tccatttccg ggtctcgcaa tcttgcatac gtcatttata cgtccggtac 372661 gaccggaaag ccaaagggcg tgcagattga gcatcgtaat ctgacaaact atgtctcttg 372721 gtttagtgaa gaggcgggcc tgacggaaaa tgataagact gtattgcttt catcttacgc 372781 atttgacctt ggctatacga gcatgttccc tgtacttctg ggcgggggcg agctccatat 372841 cgtccagaag gaaacctata cggcgccgga tgaaatagcg cactatatca aggagcatgg 372901 gatcacttat atcaagctga caccgtctct gttccataca atagtgaaca ccgccagttt 372961 tgcaaaagat gcgaactttg aatccttgcg cttgatcgtc ttgggaggag aaaaaatcat 373021 cccgactgat gttatcgcct tccgtaagat gtatggacat accgaattta tcaatcacta 373081 cggcccgaca gaagcaacga tcggcgccat cgccgggcgg gttgatctgt atgagccgga 373141 tgcatttgcg aaacgcccga caatcggacg cccgattgcg aatgccggtg cgcttgtctt 373201 aaatgaagca ttgaagcttg tgccgcctgg agcgagcgga cagctctata tcacgggaca 373261 ggggctcgcg agagggtatc tcaacaggcc tcagctgaca gccgagagat ttgtagaaaa 373321 tccatattcg ccgggaagcc tcatgtacaa aaccggagat gtcgtacgaa gactttctga 373381 cggtacgctt gcatttatcg gccgggctga tgatcaggtg aaaatccgag gctaccgcat 373441 tgagccgaaa gaaattgaaa cggtcatgct cagcctcagc ggaattcaag aagcggttgt 373501 actagcggtt tccgagggcg gtcttcaaga gctttgcgcg tattatacgt cggatcaaga 373561 tattgaaaaa gcagagctcc ggtaccagct ttccctaaca ctgccgtctc atatgattcc 373621 tgctttcttt gtgcaggttg acgcgattcc gctgacggca aacggaaaaa ccgacagaaa 373681 cgctctgccg aagcctaacg cggcacaatc cggaggcaag gccttggccg caccggagac 373741 agcgcttgaa gaaagtttat gccgcatttg gcagaaaacg cttggcatag aagccatcgg 373801 cattgatgac aattttttcg atttaggcgg ccattcatta aaagggatga tgctgattgc 373861 caacattcag gcggaattgg agaaaagcgt accgcttaaa gcactgttcg agcagccgac 373921 agttcgccag ctggcggctt atatggaggc gtctgctgtt tcaggcggcc atcaagtact 373981 caaaccggct gacaagcagg atatgtatcc attgtcatcc gcacagaaac gaatgtacgt 374041 gctcaatcag cttgaccgcc agacgataag ctacaacatg ccatctgttc ttctaatgga 374101 aggagagctt gatatttcgc gcctgcgcga ctcactcaat cagcttgtga accgtcacga 374161 atcattgcgg acgtcattta tggaagctaa tggtgagcct gttcagcgca tcattgagaa 374221 ggcggaggtt gatcttcatg tgtttgaagc caaagaagac gaagcggacc aaaagattaa 374281 ggaatttatc cggccattcg acttaaacga cgcaccgctc attcgcgcag ctttgcttcg 374341 aatagaagcg aaaaaacatt tgctgctttt agatatgcat catatcatcg cagacggcgt 374401 ctcaagaggc atctttgtaa aagaattggc gctgctttac aaaggagagc agcttccgga 374461 gccgacgctt cattataaag atttcgccgt ttggcaaaat gaagctgagc aaaaagaacg 374521 gatgaaggag catgaggcgt actggatgtc agttctttca ggcgagctgc cagagcttga 374581 tctcccgctc gattatgccc gtccgcctgt gcaaagcttt aaaggagata cgatccgttt 374641 ccgtacggga agtgagacgg caaaggcggt agaaaaactg cttgccgaaa ccggaacgac 374701 cttgcacatg gtgctccatg ctgttttcca cgtcttttta agcaaaattt ccggacagcg 374761 ggatatcgtc atcggctccg ttactgccgg ccggacgaat gctgatgttc aggacatgcc 374821 gggaatgttc gtcaatacac ttgccctgag aatggaagcg aaagaacagc aaacatttgc 374881 ggagcttttg gagctagcaa agcagacgaa cctgtcagcc cttgagcatc aggagtatcc 374941 gtttgaagat ctggttaatc agcttgatct ccctcgggat atgagccgaa acccattgtt 375001 taatgtgatg gtgacgacag aaaaccctga taaagaacag cttacattgc aaaatctgag 375061 catttcacct tatgaggctc atcagggaac ttctaagttt gatctgacac tgggcggatt 375121 tactgatgaa aatggcattg gcttgcagct cgaatatgcg acagatctgt tcgcaaaaga 375181 aacagctgaa aaatggagcg aatacgttct gcggctacta aaggctgttg cggataaccc 375241 gaaccagccg ctttccagtc tgttactggt caccgagaca gaaaagcaag cgcttcttga 375301 ggcatggaag ggcaaagcgc tgcctgtgcc gacagacaaa acggttcatc agctattcga 375361 agagactgtc cagcgccaca aagaccgccc ggctgtcaca tacaacggcc aatcttggac 375421 gtacggcgag ctgaacgcga aggcaaaccg cctcgcccgg attctgatgg actgcggcat 375481 cagcccggat gaccgcgtcg gcgttctcac gaagccgtcg cttgaaatgt ccgccgcggt 375541 gctcggcgtc ttgaaagccg gagcggcgtt tgtgccgatt gatcctgact acccggatca 375601 gcggattgag tatattttac aggacagcgg cgcgaagctt ctcttgaaac aggaaggcat 375661 ttcagtgccg gacagctata cgggagatgt cattcttctc gacggaagcc gcacgattct 375721 aagcctgccg cttgatgaaa acgacgaggg aaatccagaa accgctgtaa ccgcggagaa 375781 cttggcgtac atgatttaca cgtctggaac gaccggacag ccgaagggtg tcatggtcga 375841 gcaccatgcg cttgtgaacc tgtgcttctg gcaccacgac gcgttcagca tgacagcgga 375901 ggaccgcagt gcgaagtacg cgggcttcgg gttcgacgct tccatttggg agatgttccc 375961 gacctggacg atcggcgctg aacttcacgt cattgatgaa gcgatccgcc tcgatatcgt 376021 ccgcctgaac gattattttg aaacgaacgg cgtaacgatc acgttcctgc cgacacagct 376081 tgcggaacag ttcatggagc ttgagaacac atcacttcgc gtcctcttga ccggaggaga 376141 caagctgaag cgggcagtga aaaagccgta cacactcgtc aacaactacg ggccgacaga 376201 aaatacggtc gttgccacaa gcgcagaaat ccatccggag gaaggctcgc tttccatcgg 376261 acgggccatt gccaatacga gagtatacat tctcggcgag ggcaatcagg tgcagccgga 376321 aggcgtagcc ggagagcttt gcgtggcggg gcgcggactg gcacgaggct atctgaatcg 376381 agaagacgaa accgcgaagc ggtttgtcgc tgatccgttt gtgccgggtg aacgcatgta 376441 ccgcaccggc gacttggtga agtgggtgaa cggcggcatc gaatacatcg gccggatcga 376501 ccagcaggtc aaggtccgcg gctaccggat cgagctctca gaaattgaag tccagctcgc 376561 ccagctttct gaggtgcagg atgcggcggt gacagctgtc aaagataaag gcggcaatac 376621 agcgatcgcg gcgtatgtca caccggaaac agctgacata gaagcactaa aatcaacact 376681 aaaggaaacc ctgccggatt acatgatccc ggcgttctgg gtgacgctga acgagcttcc 376741 ggttacggca aacggcaaag tcgaccgcaa agccttgcct gagccggaca tcgaagcggg 376801 aagcggagaa tacaaagcgc cgacgaccga catggaagag ctgcttgccg gcatctggca 376861 ggacgtgctt ggaatgtctg aagtcggtgt caccgacaat ttcttctcgc ttggcggaga 376921 ttccatcaaa ggaattcaaa tggcgagccg cttgaatcag cacggctgga agctggaaat 376981 gaaagatctc ttccagcatc cgacgatcga agagctcacc cagtacgtag agcgtgccga 377041 aggcaaacag gcagaccaag gcccggtgga gggcgaagtc atcctgacgc cgatccagcg 377101 ctggttcttt gaaaagaact tcacgaacaa gcaccactgg aaccaatcgg tgatgcttca 377161 cgccaaaaag ggctttgatc ctgaacgggt ggagaaaaca ttgcaggcgc tgatcgagca 377221 tcatgacgcg ctccgcatgg tctaccgcga ggaaaacggg gacatcgttc aggtgtataa 377281 accgatcggt gagagcaagg tcagcttcga aatcgtggat ctgtacggct ccgatgaaga 377341 gatgctgaga agccagatta agcttctcgc gaacaagctg caaagcagtc tcgatctgcg 377401 aaacgggccg cttttaaagg cggagcaata tcgcacagaa gctggggatc acctgctcat 377461 tgctgtacac catctcgtgg tcgacggtgt gtcatggcgg attttgcttg aagactttgc 377521 ttcaggctac atgcaggctg agaaagaaga gagccttgtc ttcccgcaaa aaacaaactc 377581 cttcaaggat tgggcggaag aactggcggc attcagccaa tcagcgcatc ttttacagca 377641 ggctgaatac tggtcgcaaa ttgccgctga acaggtttct cctttaccta aggattgtga 377701 aacagagcag cggatcgtca aggatacatc atctgtccta tgtgaattaa cggcagaaga 377761 cactaagcat cttttaacag atgttcatca gccatatgga actgaaatca acgatattct 377821 tctcagcgcg ctcggtttga caatgaaaga atggacaaag ggggccaaaa ttggcattaa 377881 ccttgaggga cacggccggg aggacattat cccgaatgtg aatatctcca gaacggtcgg 377941 ctggtttacg gcacaatacc ctgttgtgct cgacatatct gacgcagatg cctcagctgt 378001 gatcaaaaca gtcaaagaaa acctgcgccg cattccggac aaaggtgttg gctacggcat 378061 tcttcgttat ttcacagaaa cagcggaaac aaagggcttc acaccggaga tcagcttcaa 378121 ctatttgggc caattcgaca gtgaagtcaa aaccgatttc tttgaaccgt ccgctttcga 378181 tatggggcgc caagtaagcg gagaatcaga ggcgctgtac gcattaagct tcagcggcat 378241 gatcagaaac ggccggtttg tgctttcctg ctcctacaat gagaaggagt ttgaaagagc 378301 tacagtcgag gagcaaatgg aacggtttaa agaaaacctc ctgatgctaa tccgccattg 378361 cacggaaaaa gaagacaagg aattcacacc aagcgacttc agcgccgaag accttgaaat 378421 ggacgagatg ggagatatct ttgacatgct tgaggagaat ttaaaataaa acgcaaggga 378481 attacagaag gcgggagcga aacatatgag tcaatttagc aaggatcagg ttcaagatat 378541 gtattaccta tcgccgatgc aggaagggat gctttttcat gccatcctga atcccggcca 378601 aagcttttac cttgaacaaa tcacgatgaa agtaaaaggc agcttgaata tcaaatgtct 378661 tgaagaaagc atgaatgtga tcatggaccg gtacgatgta tttcgtaccg tgttcattca 378721 cgaaaaagta aaaaggcctg tccaagtcgt attgaaaaaa cggcagttcc atatagaaga 378781 aatcgatctg acacacttaa cgggcagcga gcaaacagcc aaaatcaatg agtacaaaga 378841 acaggataag atcaggggtt ttgatttgac gcgggatatt ccgatgcggg cagccatttt 378901 caagaaagct gaagaaagct ttgaatgggt gtggagctac caccacatta ttttggacgg 378961 atggtgcttc ggcatcgtcg tacaggatct atttaaggta tacaatgctc tgcgcgaaca 379021 aaagccgtac agcctgccgc ccgtcaaacc gtataaagac tacatcaagt ggcttgaaaa 379081 gcaggataaa caagcatcac tgcgttactg gcgcgaatat ttagagggct ttgaaggaca 379141 aacgacgttt gcggagcaaa gaaagaaaca aaaggacggc tatgagccga aagagctgct 379201 cttttcactg tcggaggcgg aaacaaaggc ctttaccgag cttgcaaaat cgcagcatac 379261 cactttgagt acggcgctgc aggcagtctg gagcgtattg atcagccgct atcagcagtc 379321 tggcgatttg gccttcggta cagttgtttc agggcgtccc gcggaaatca aaggcgttga 379381 acatatggtc gggctgttta tcaacgttgt cccgagacgt gtgaagctgt ctgagggtat 379441 cacatttaac ggcttgctca agcggctgca ggagcaatcg ctgcagtccg agccgcatca 379501 atatgtgccg ctttatgaca tccaaagcca ggccgatcag ccgaaactga ttgaccacat 379561 cattgttttt gagaactatc cgcttcagga tgcgaaaaat gaagaaagca gtgaaaacgg 379621 ctttgatatg gtggatgttc atgtttttga gaagtcgaat tatgatctca acctgatggc 379681 ttccccggga gatgagatgc tgattaagct tgcctataat gagaatgtgt ttgatgaggc 379741 gtttatcctg cgcttgaaat ctcagcttct tacagcaatt cagcagctca tccagaatcc 379801 tgatcagcct gtcagcacga tcaacctcgt tgacgacagg gagagagaat ttttgctaac 379861 cggcttaaac ccgccggctc aagctcatga aacaaagcct ctgacgtatt ggttcaagga 379921 agcagtgaac gccaatccgg atgcaccggc gcttacgtat tccggccaga ccctgtctta 379981 tcgcgaatta gatgaggaag cgaaccgcat tgcacgccgg ctgcaaaaac acggtgcggg 380041 caaaggctct gttgtagcgc tgtacacgaa gcgctcactt gaactggtga tcggcattct 380101 cggtgtatta aaggcgggag cagcctatct gccggttgat ccgaagctgc cagaggaccg 380161 aatctcgtat atgctggctg acagtgcggc agcctgtctt ctgacgcatc aggagatgaa 380221 agaacaagcg gctgagctgc cgtatacagg cacaacgctc ttcattgatg atcaaacacg 380281 gtttgaagaa caggcaagcg atcctgcaac cgcgattgat cctaatgatc cggcatatat 380341 catgtacacg tccggcacaa ccggaaagcc aaagggcaat atcaccactc atgccaatat 380401 tcaaggattg gtcaagcatg tagactacat ggcattttct gatcaggata cgttcttgtc 380461 tgtttcgaat tacgcctttg atgcatttac ctttgatttc tatgcttcta tgctgaatgc 380521 ggcacggctc attatcgcag atgaacatac gctgcttgat acagaacggc tcacagatct 380581 gatcctgcaa gagaatgtca atgtcatgtt tgcgacaacc gcactattta atcttctcac 380641 agatgcggga gaggattgga tgaaggggct tcgctgtata ttattcggcg gagagcgcgc 380701 gtcagtgcct catgtcagaa aagcgctgcg gatcatgggg ccgggcaagc tgattaactg 380761 ctacgggccg actgagggaa cagtgtttgc gacagctcac gtcgtgcatg atctgccgga 380821 ttccatctcc tcattgccga tcggaaagcc gatcagcaat gccagtgttt atattctgaa 380881 tgagcaaagc cagctccagc cattcggggc ggtcggtgaa ctgtgcatca gcggaatggg 380941 cgtgtcaaaa gggtatgtaa atcgtgctga cctcacgaag gaaaagttta tcgagaaccc 381001 gttcaagccg ggagaaacgc tttaccgtac aggggattta gcgcgctggc tgccggatgg 381061 aacgattgaa tacgccggcc gtattgacga ccaggtcaaa atacgcggac accggattga 381121 gcttgaagaa atcgaaaagc agctgcagga atacccaggt gtgaaagatg cggtcgttgt 381181 ggcggaccgc catgagtctg gcgatgcatc aatcaatgcc taccttgtga accgaacgca 381241 gctttcagct gaagacgtga aggcgcacct gaaaaaacag cttcctgctt acatggtgcc 381301 gcaaaccttt accttcttgg atgagcttcc tttaacgacg aacgggaaag tcaataaacg 381361 gctgctccca aaacctgatc aggatcagct ggcggaagaa tggattggac cgcggaacga 381421 gatggaagaa acaatcgcac aaatatggtc tgaggttctc ggcagaaagc aaattggcat 381481 tcatgacgat ttctttgcgc tcggagggca ttccttgaag gccatgaccg ccgcgtcccg 381541 catcaagaaa gagctcggga ttgatcttcc agtgaagctt ttgtttgaag cgccgacgat 381601 cgccggcatt tcagcgtatt tgaaaaacgg gggctctgat ggcttgcagg atgtaacgat 381661 aatgaatcag gatcaggagc agatcatttt cgcatttccg ccggttctgg gctatggcct 381721 tatgtaccaa aatctgtcca gccgcttgcc gtcatacaag ctatgcgcct ttgattttat 381781 tgaggaggaa gaccggcttg accgctatgc ggatttgatc cagaagctgc agccggaagg 381841 gcctttaaca ttgtttggat attcagcggg atgcagcctg gcgtttgaag ctgcgaaaaa 381901 gcttgaggaa caaggccgta ttgttcagcg gatcatcatg gtggattcct ataaaaaaca 381961 aggtgtcagt gatctggacg gacgcacggt tgaaagtgat gtcgaagcgt tgatgaatgt 382021 caatcgggac aatgaagcgc tcaacagcga agccgtcaaa cacggcctca agcaaaaaac 382081 acatgccttt tactcatact acgtcaacct gatcagcaca ggccaggtga aagcagatat 382141 tgatctgttg acttccggcg ctgattttga catgccggaa tggcttgcat catgggaaga 382201 agctacaaca ggtgtttacc gtgtgaaaag aggcttcgga acacacgcag aaatgctgca 382261 gggcgaaacg ctagatagga atgcggagat tttgctcgaa tttcttaata cacaaaccgt 382321 aacggtttca taaatgaagt gatgaaagga ggagacagcc aatgagccaa ctcttcaaat 382381 catttgatgc gtcggaaaaa acacagctca tctgttttcc gtttgccggc ggctattcgg 382441 cgtcgtttcg ccctctccat gcttttttgc agggggagtg cgagatgctc gctgccgagc 382501 cgccgggaca cggcacgaat caaacgtcag ccattgagga tctcgaagag ctgacggatt 382561 tgtacaagca agaactgaac cttcgccctg atcggccgtt tgtgctgttc ggacacagta 382621 tgggcggaat gatcaccttc aggctggcgc aaaagcttga gcgtgaaggc atctttccgc 382681 aggcggttat catttctgca atccagccgc ctcatattca gcggaagaaa gtgtcccacc 382741 tgcctgatga tcagtttctc gatcatatta tccaattagg cggaatgccc gcagagcttg 382801 ttgaaaataa ggaggtcatg tcctttttcc tgccttcttt ccgatcagat taccgggctc 382861 ttgaacaatt tgagctttac gatctggccc agatccagtc gcctgttcat gtctttaacg 382921 ggcttgatga taaaaaatgc atacgagatg cggaagggtg gaagaagtgg gcaaaagaca 382981 tcacattcca tcaatttgac ggcgggcaca tgttcctgct gtcacaaacg gaagaagtcg 383041 cagaacggat ttttgcgatc ttgaatcagc atccgatcat tcaaccgtga tcaaaagcgg 383101 acagcttcgg ctgttccgct ttttttgtgt tgaatgccaa tttctgcatg gtataatagt 383161 cgaaatactc aaataaaggc aggtcgaaac atgcgcacgt ctcccaggat gaaatggttt 383221 gtattgctgt ttacgtttgt tttcgccatc ggaatgaact cattcagaaa ttcctttcaa 383281 ttttttatgc tgccaatggc agacgccttc catgccgaca ggtcgctgat ttcggtttct 383341 gtcagcattt ttatgatcac aaccggcatc gtccagtttt ttgtcggttt ttttatcgac 383401 cgtttcagtg tcagaaaaat tatggcgctg ggagctgttt gcatcagcgc aagctttttg 383461 gtgcttcctt attcaccgaa tgttcatgtg ttttccgcca tttacggtgt gcttggcgga 383521 atcgggtatt cctgcgcggt cggcgtgacg acccagtatt tcatcagctg ttggtttgac 383581 acacacaaag gtctggcgct tgctattttg accaatgcca actctgcggg cctgctgctt 383641 ctctcgccca tttgggctgc ggctccgtat catgccggct ggcagagcac ctataccatt 383701 ttgggaatcg tcatggcggc tgttctgctg ccgctcctcg tctttgggat gaagcacccg 383761 ccacatgcgc aagcggaaac tgtgaaaaaa tcttatgatt ggcgagggtt ttggaacgtg 383821 atgaagcaat cccgcctcat tcatatcctg tacttcggcg tgtttacttg cggatttaca 383881 atgggaatta ttgatgctca cctcgtcccg atactgaagg atgcgcatgt ctctcatgtc 383941 aacggaatga tggccgcgtt cggggcattt atcatcattg gcggattatt ggcgggctgg 384001 ctgtcagatc tcctcggcag cagaagcgtc atgctatcca tcttattttt cattcggctg 384061 ctcagcctca tttgcctgct cattcccatt ctcggaattc atcacagcga cctttggtac 384121 ttcgggttta tcctgttatt cgggctcagt tacacaggcg tgatcccgct gaccgcggcg 384181 tcaatttcgg aaagctatca aacaggattg atcggatcgc tgttaggcat caatttcttt 384241 atccatcagg ttgccggagc tctcagcgtg tatgcgggcg gtttgttttt tgacatgact 384301 catggttatt tactgattgt cgctgtgtgc atcgtgtttg tgggtttatc ggctgtaata 384361 gagctggtgc cgtttttaga taaacagaag gcaaaagaaa cccaccattc aatataaaag 384421 gatcagcact gtcaatgctg atccttttta aatttgagtt tttttgtttc ggtattttta 384481 aggataatct ccttgaatct gttcatctcc tcttcggagt gaaaaaaatg tttggggatc 384541 gcaatatatt ggccacttga tgtattgacc ctgaagatat ttttatattc gaaaacagct 384601 gtaatttcat cccaattgaa aatgaggtca tattttttag aacatatacg aattccttct 384661 tggttcagag tatatgttct tttggatttc atccgttcgt tcttcttgta tgctctggaa 384721 aacttcacat atagaagaag gaggagcagc agtgtaaaca gaacggacat cacgataatc 384781 aacatactgt tcataaacaa gttaagcgcg tcacttccat aaacgatacg gggccatccg 384841 ttaatgaagt taactgcagc aaatatggcg caaaacaata gaaagtaaaa gcatgatatt 384901 tttgcgattt gataaaaaaa gatttctctt acatccttaa aagtgatttc tcctggaaga 384961 ttgatacttt cactagcata ttgaatcata cggtaaacct acacctctaa ccatgttttt 385021 ccttttagtc tagcataatt tctcattttt ttgcaggcat accagggcgc tttgtttttt 385081 tctccagatt gatattgctc cccaccacgc caatcataat acaaacagcc ccggcaagat 385141 gataccaggc caggctttcg ttgagaatca caaatcctgc aatcatcgtc acaatggtag 385201 atacatgatt aaaagcgctc attttaaacg cctcaattcg cgacagcgta tagttagaca 385261 gaaatgaagt gacaagtgaa gacagcacgc ccaaatacac aatggcgaga acgaagccgg 385321 gctcccggaa cggcagaaaa taagtgccga ctgttcccgc cgctccgtga cgcacaaggg 385381 cgatggcgtt gaagacgaca aagccgatgg ctgacatgat gtaggtgagc tcggtcagct 385441 tgaaccgctg cgtcattttt ctggcagcag tattgtacat cgctgaagac aaagcggaca 385501 ataggatcag caaagaccct tttaagctgg ctgattccac gtcaacgcct ttcatcacaa 385561 aaataaacat gacgccggca acggataaaa ccgtgaaccc cttttgcgtc cacgttgggc 385621 gttcctttaa aacataagcg gcaaagacca tcgtgaaaat cggaatggct gcctgaataa 385681 ttcccgcttc agaggaggac gagtacacaa ggccgaatgc ctgaaagctg aaaaataacg 385741 cgggatacag cagggcgagc ggcaaaatgt caatgacgtc ctttacgcgg attgatagct 385801 ttacccagcc gaataagatc ggtacagtgg ccgcagcaaa cgcaatggtg aaccgatgcg 385861 ccaaaatatc aaacggctct gctgtttgca gtgcgatttt tacgaataga aaggataaac 385921 cgataatgaa cgaatataaa atagccgcta tataagcggg ggtttgctga tgtttaacca 385981 taatgggaag ggctccttta cctgaattgc agcgccggtc gctcccttta ttgtatggcc 386041 gcggtcagaa cggtacaatg agaaaaacaa tgaactgtac cggtacaaaa cagggggaga 386101 aggcatggag aaatatatga gtctattaac gaggatagag gagatgatgc aaagcacctc 386161 atatcaagaa ggagacaggc ttccatctat ccgtcagctg tccgcccgct accaagtcag 386221 caaaagcaca gtgatccgcg cgctgcagga gctggaaaag cgccacctta tctattctgt 386281 tccgaaaagc ggctattata ttgtgaaaaa gtcagggaaa tcaaaaagcg ggcagcctgg 386341 ccccatcgac tttgccacat ctgcgccgga tcccgatgtg tttccgtatc ttgattttca 386401 gcactgcatc aacaaagcga ttgatacata caaaaacgat ttgtttattt atgggacgcc 386461 aaaggggctt ccatcactca tccgcgtact ccgaaagctc ttggccactc aacaggtatt 386521 tgcggatgaa cggcatattt tcattacatc aggtgtccag caggcgttat ccttgctttg 386581 tgccatgccg ttcccaaatg ggaaagagaa gatcgccatt gaacagccgg gctaccattt 386641 gatggtcgaa cagcttgaga cacttgggat tcccgccatc ggggtgaaac gaacggaaga 386701 agggcttgat atagccaagg ttgagcggtt atttcaaaca gaatcgatta aattttttta 386761 tacgatgccg cgcttccata acccgcttgg gtgctcattg tcagagcgtg ataaacagga 386821 gcttgtgaga ctggcagaag cgtatgatgt ctatctcgtt gaggatgatt acctcggtga 386881 tctggaggaa aataaaaagg cagatccgct gtacgcatat gatctgtcct cacatgtcat 386941 ctatttgaaa agcttctcga aaatgatgtt ccccggcctc cgcgtggggg cggctgtttt 387001 gcccgaagcg ctgactgaca cgttctatgc gtacaaaaag ctgaacgaca tcgactgttc 387061 gatgatttct caagcggcat tggagattta cctgaaaagc ggtatgtacg gcaggcataa 387121 ggagaaaatc agagattctt ataaagagcg gtcgctgagg ctacatcaag ccattcgaac 387181 tcacaggcag ctgggaagcg gacgctttac gttctccagc gggcaggcac cctgtatgca 387241 cacccatctg gtgcttcctc aggatctgcc cgcctcaaga gtgattcata gactggaaaa 387301 acaaggggtt ctccttgagg cgatagaccg tcattattta tcagattatc cgaaagaaaa 387361 tctattaaaa atcaatattt ccaatgtgaa aacggaagat attgagcgcg gtgtcaagct 387421 gttgatgagc catttataaa agctcttcgt acgagaccat tgtgatatcc tcggggaaat 387481 cagggtgtac ggcgcataca gccattttgt agccgggatc gacctcatac gttttgatat 387541 agcatgggga atggctgtcc ggaagctcaa tggatacttg tccgtcctgg tgcaggcgca 387601 ctgaaaagga atcaagcgga agcgataagc ctttgccttc cttgtttgat aaagctttct 387661 ttcattgacc atagatgata aaaatagtct gtctgctcgt ccttgtcttt tgctaaaagg 387721 tcgctgtact ctgtttttga aaagaagcgc ttggcgatct caaggctgat cggtttcgtt 387781 ttttcgatat ctatgccgat cggctgtgaa tcaaacgcgc aaatgaccca gcgtccggag 387841 tgagaaatgt tgaaatgagc gtcgggaaga tcagggatgc acggcttccc gtattcctgc 387901 gtgctaaagc ggatatcgga tttgtccaac tgatactgcc tgcttatgac tgagcgaacg 387961 agcacatctc ccagcagggt gcggtgagca tcttctttat gataaaatct ccggcatttc 388021 tcccgttttt caggtgatat gaaagacatg aaccgttcat tttcttcctg tgaaagcggg 388081 cggtccatat aaattccgta aatcttcatt ctagatcctc cgtctgcaaa agattgtcaa 388141 aaccatccta tcatacttcc acaagactca tatagaggag aaaataaaaa aacaaagcca 388201 aggcggcttt gttttagtgt acaggcggag atgctttcac tgcggctgtc cgccttgcca 388261 cagcataatt cagcaactgg attgactggg gcaatgaaaa acgcaaaata agtccggtga 388321 ggatggcggt caaaatggtg ccaaaaccga tcggtccgcc catgccccat gccgcaaaca 388381 aaatggttaa ttccatgccg ttccgcaccc attgcacatt ccagccggtt ttttctgtaa 388441 tcagcatcat cagtgaatca cgcggccccg cgccaaggcc tgctgataca taaacaccga 388501 cgccgtaacc aatcagcacc acgcctagag agaagacgat gatcgagcct gtgtaggtcg 388561 agagggcagg cagaatgaaa ttgaaaaaat ctataaatac accaatgagc accatattca 388621 ggagggcacc aattttcggc caagctctcg taaacaatga cgtgaatccg acgatgagcg 388681 ctccaataat gatggaccac tggccgacgg taagcccgaa gtgctgaaac aggctgtaat 388741 gaaatgcatc ccacggacta atgccgagtg cttttccttc tatcgtcagg gatacaccaa 388801 aagccaaaat gatcaaaccg gcaaaataaa atgtccagcg cagaacaagt tcttgcttca 388861 cgtgaggtcc cttctttcgt aaaaatcagt cgattgtcat tgtagcacat ctgacagaag 388921 ggcggaatag gcgaaagggg ctcaacaaaa aaacagggcc gccggaggcg ccctgtttca 388981 gcgtgttggc aaacccttgc attcgttgtc aggcctgtgc ttcggtgctc acgaatttaa 389041 cattagctgt gctccaatgc tcgcccttcc tagacttcaa aggttttcaa tcacgctgaa 389101 aatcacaaaa tcctaaaacg aatatcgttt taggattttg tcaataatct gaaacagggc 389161 gctgacgctc tgtttttctt attacagcgg gttcaaaatc cggtttaaga accgctgtgt 389221 ccgttcttct tttggtgcgg agaaaatttg ctccggcggt ccctgctcca cgataacgcc 389281 gccgtcgatg aagatgactt catccgcaac ctcctgcgcg aacttgattt cgtgggtcac 389341 gacgaccatg gtccagcctt cattggccaa gtccttgata accttcagca cctctccgac 389401 aagctcggga tcaagcgctg aggtcggttc gtcaaacagc atgagctcag gctgtatcgc 389461 cagtgcgcgg gcgatgccga cgcgctgctg ctggccgccg gaaagctgga acggatataa 389521 atccattttg tccttcaatc cgactttatc aagaagctga atcgcttctt ttctgacttc 389581 ctctttgttc cgtttttgca cctgaacagg gccctccatc acgttttcga gggctgtgcg 389641 gtgcgggaac aggtgatacg cctgaaacac cattccggat tttcggcgaa gctttaggat 389701 atccgcctgt ttcacctttt tggagaaatc gatggagaaa tcatcaaatg caagctctcc 389761 gcgattcggg atctccagag cgttcaggca gcggagcagc gtcgttttcc ctgaacctga 389821 aggcccaagt atggcgatga cttttccttt ttcaatcttc atatctatct tttttaaaat 389881 ttcattttca ccgaatgatt tgtttaatcc tttaacggta agcatactcg gaacctcctt 389941 atttggccac gtagcggtca agacgccgtt cgatgacatg ctggacgagt gagagcagga 390001 agcagataat ccaataaata aaggctgctt caatatagat cactaaaatt tgatcaagat 390061 tccgcgcgcc gatttcctgg gcttttctga acagctcagc gaccagaatt tgagaggcga 390121 gggatgtatc tttaatcagg ctgataaagg tattggataa tggcgggatc gacacacgaa 390181 acgcctgcgg caaaatgacg cggaacagcg ttttttgatg tgtcatgcca attgtgtagc 390241 cggcttccca ttgccctttc ggcacggata aaatagatgc ccgaatgatt tcagatgcat 390301 aggcgccgac gtttaatgaa aaggcgataa ctgcgcttgg aaatggatct aatgtgacgt 390361 taaaggccgg gaacagatag aaaatgatga acaattgaac gagaagagga gtgccgcgta 390421 ttgcggatac gtatacgctg aacacccatc tcaaaggtct cactttcgac attctggcaa 390481 gcgccgtaat cagcgccagg atcattccga atataaagga aagaatcgta aggggaatcg 390541 tatagtagat tccccctgaa agtatcggcc agaatgactg ctgcaccaga tcccacggga 390601 tcgccgtgcc aagcgtcaat gccggcagat tatttagaaa catcttcgcc gaaccatttt 390661 ttagaaattt tagaaagagt cccgtcctct ttcatttctt ttaatgcttt gttgacttga 390721 tcaacaacct cgccgcttcc tttacggaac gtgaaatatg ttgactgagg ctcacctgtt 390781 tcaaacgcga ttttcacgtt tttattgcca gatgttttta agtagttcaa tacggcaagc 390841 ttatcgttgt atgtcatatc gacgcggcct tgctggatca tttgaagggc ctgcgccatg 390901 ccttcaacgc cttctacttt agcgccggca tttgtagcta atttgttgta gttgcttgtc 390961 agtgattgag ctgacgtttt tccttttaca tctgcttcag acttaatatc gttgttgtct 391021 tttttcgtta cgacaacggc tcttgatgtt gtgtatttat ctgagaaatc atatttgtct 391081 tcacgatctg tttttccgac ttggttggca acaacgtcaa accgtttgga attcaggccg 391141 gcaaacatac tgtcccattg tgtttcctta aagtcgactt taagcccgag gcgttttgcg 391201 acttctgtga taacttcgac atcatagcca gtcagtttat cagtgtcttt gtcgtggtaa 391261 gtgaacggct catatgttcc ttccgttccg actgtgagca cacctttttt cttaattgaa 391321 gcccaaagat cgccatcttt ggcattatct tttgactgat tgtcatttcc tgctccgcaa 391381 gctgcaagag ctgcaatact tacgaccatg aataaagcca ataatgcttt tttcatctta 391441 ttccccactt ttctggttga ttttattgaa ataaaaaatt agcttacaaa tctaaaggat 391501 aacttttttt tagtatgagt caagtatttg gttttcataa gacaaaatct tttaaaataa 391561 atccaaaaat tgctgtgccg gtttaggcaa ataactgtcc gttctccaca tgacagccgg 391621 tgtcataatg aagggattat tttcgatatg gacggtgtga acgtgatttc tcatatgaac 391681 gggaatcatt gtgacaggca aaatagacgc gccgaatccg gatgacacga ggctgagcaa 391741 agttgcagag tcgtggcatt cacaaacaat gcgcggctcc aggttcaaac gatgaaattc 391801 attcatgacc tgattataga cgccttttcc gttgacaggc cgcagcagga tcagcggaaa 391861 tgaaggaatg tccaccatct taatggtgtc tccgcacgga tatccggctt catctgaaag 391921 cacgagcaca catggaatgt catcaagctg cttgaattgt actgtgtcac ttttgatcag 391981 tgttgtcgtg accgccgcat cgatttgccg gctttccagc agttccaaca gtgtcgcggg 392041 ttcattttcc caaatattaa aggtgagatg ggggtatctc tctttgatct gtgttacttt 392101 ttcaagcatc agagccgcgc aataaatcgt tgatcccacg gcaagtgtac cggctacttc 392161 ctccttcagc tcctgtacct caatgactgc atcttcaaac ctatgcagaa tctcttttgc 392221 tctttttaga aaaacagctc cttcatatgt aagagtcatt tgttttttct tgttacggtc 392281 aaacagaaca acaccaagtt cgtcctccag ctgtttgagc tgcctgctta aaggcggctg 392341 cgccatgtga agctttttgg ctgcggacgt aattttctgt tcttgggcaa tggtaatgaa 392401 gtatcgaagc tggcgaatat ccaaaagaaa gcgcctcctt atcatacctt ttaggtatta 392461 attatagatt taatagatat ttttcatatg gatatatcag gagtatgatt gaaatgaaag 392521 cagaattcaa gcgtaaagga gggggcaaag tgaaactcgt tgtcggaatg acaggggcaa 392581 caggggccat tttcggggtc aggctgctgc agtggctgaa ggccgccgga gtggaaaccc 392641 atctcgttgt gtctccttgg gcaaacgtca cgatcaaaca cgaaacaggc tatacgttac 392701 aagaagtaga acaactggcc acatacactt actcacataa ggatcaggcg gcagccattt 392761 caagcgggtc gtttgatacc gatggaatga ttgttgcgcc gtgcagcatg aaatctctcg 392821 caagcattcg cacaggaatg gcggataatc tgctgacacg tgcggcggat gtcatgctca 392881 aggagagaaa aaaactcgtc ctcttaacga gagagacgcc tttgaaccaa attcatctcg 392941 aaaatatgct agcgcttacg aaaatgggca ccatcattct tcctccgatg ccggcatttt 393001 ataatcggcc gagaagctta gaggaaatgg ttgaccatat tgtttttaga acgttggacc 393061 aattcggcat tcggcttcct gaagcgaagc gctggaatgg gattgaaaaa caaaaaggag 393121 gagcttgatc atggcttatc aagatttcag agaatttctc gctgcccttg aaaaagaagg 393181 acagctgctt acagtgaatg aagaggtaaa gccggaaccg gatttagggg cctccgcacg 393241 ggcagccagc aatcttggcg ataaaagccc tgcgctctta tttaacaaca tttacggcta 393301 tcataacgcg cgaattgcga tgaatgtcat cggctcttgg ccaaaccatg ccatgatgct 393361 gggcatgccg aaagacacac cggtaaaaga acagtttttt gaattcgcaa agcgttatga 393421 ccagtttccg atgccggtca aacgtgagga aacagcgcca tttcatgaaa atgaaatcac 393481 agaagatatc aatttgttcg atatactgcc tcttttcaga attaaccagg gtgatggagg 393541 ctactattta gacaaagcat gtgtcatttc ccgtgatctt gaggaccctg acaacttcgg 393601 caaacaaaat gtcggcattt acagaatgca agtcaaagga aaagaccgcc ttggcattca 393661 gcctgtcccg cagcacgata ttgcaatcca tctgcgccaa gctgaagaac gcggcatcaa 393721 ccttccggtc actattgcgc tcggctgtga gccggtcatt acaacggcgg catcgactcc 393781 gcttctctat gatcaatcag aatacgaaat ggcaggtgcg attcaaggcg aaccatatcg 393841 catcgtcaaa tcaaagctgt ctgatcttga tgttccgtgg ggcgctgaag tggtgcttga 393901 aggtgagatt attgccggag agcgcgaata tgaagggccg ttcggtgaat tcacaggcca 393961 ttattccggc ggacgcagca tgccgattat caaaattaaa cgcgtctatc acagaaacaa 394021 tccgatcttt gaacatttat acttaggcat gccttggaca gaatgcgatt acatgatcgg 394081 cattaacaca tgcgtgccgc tttatcagca gttaaaagaa gcgtatccga acgaaattgt 394141 ggcagtgaac gccatgtaca cacacggttt aatcgcgatt gtttccacaa aaacccgcta 394201 tggcggattt gcgaaagcgg tcggcatgcg cgcactcaca acgccgcacg gactcggcta 394261 ctgcaaaatg gtcatagtcg ttgatgagga tgtcgatcca ttcaaccttc cgcaggtcat 394321 gtgggcgctt tcgaccaaaa tgcatccgaa acatgatgcg gtcatcattc cggacttatc 394381 tgtcctgccg cttgatccgg gatccaatcc atcaggaatc actcacaaaa tgattctcga 394441 cgccactaca ccggttgcgc cggaaacaag aggccattat tcacagccgc ttgattctcc 394501 gctaacaacg aaagaatggg aacaaaaact aatggactta atgaataaat aaggaaagga 394561 tgttcgaaat gcatacatgt cctcgatgcg actcaaaaaa gggagaagtc atgagcaaat 394621 cgcctgtaga aggcgcatgg gaagtttatc agtgccaaac atgctttttt acatggagat 394681 cctgtgaacc ggaaagcatt acaaatcccg aaaaatacaa tccagcgttt aaaattgatc 394741 caaaggaaac agaaacagca attgaagttc cggcggtgcc ggaacgaaag gcttgatccg 394801 cgtgaactgt atgtcagacc gtctctttga gctgcttgac gggagctgcc tgaatgagaa 394861 gcagcatgag gccttcgttc tgcaaacagt atcagaggat ggctggccgc atgccgctat 394921 gatcagtgca ggtgaaatca tcgcgctgag ccgaactgat atccgaatcg ctctgtggaa 394981 aaacacaatg acttcggcca acatccttcg cacaggaaaa gcacagttca cggcgtggtg 395041 gaagggagcg gcctattatg taaagcttga atgcgcgcct ttaccgcctt tgaaagatgc 395101 cgaatatgaa agagaccgtt tttcctgccg catcgtttca gtgaaagagg acgttgcgaa 395161 atacgctgat ttgacttcag gtgtccgtat acagcttcac agccctgaag aggtgctgag 395221 cagatggaaa aagaccctgg aagatttaaa acggtaatat cgatagcctg acgccatgcg 395281 tcaggctttt tttatataat gaaaacaaaa gggggcgtga gaaatggaac gtgcggggat 395341 ctgtcactcg gacggctttg atttagctta tcgaattgag ggcgagggcg cacccatcct 395401 tgtgatcggg agtgcggttt actatccgcg ccttttttcc tcagatatca aacagaaata 395461 tcaatgggtc tttgtcgacc ataggggatt tgctaagcct aagcgggagc ttcgtgcgga 395521 ggattcgagg cttgatgctg tcttggctga tatcgaaagg atgagaacat ttcttcagct 395581 tgaggatgtt actatcctgg gacattccgg gcacgctttt atggctttag agtatgccag 395641 gacatatccc aaacaagttc ggaaggtggc gctctttaat actgcgcctg ataacagtga 395701 agaaagacag cgaaaaagcg aatcattttt catggaaaca gccagtcttg agagaaagaa 395761 acgctttgaa aaagacatcg agaatttgcc gcaggacatc gacaaagatc ctgaaaggcg 395821 ctttgtgcac atgtgtattc gcgctgaagc gaaaagcttt tatcaagagc ggccgcatgc 395881 tgctgcctta tgggacggtg tattcacgaa tatgccgatc attgatgaat tatggggcaa 395941 tacatttgcc cggattgatc ttcttcagcg gttagctgat gttcgtatgc cggtgtatat 396001 cggattaggg agatatgatt atttggttgc gcccgtttcg ctatgggatg ctgttgacgg 396061 tttatatccc catgttgata aggttatttt tgaaaagagc ggccatcagc cgatgctgga 396121 agaaccggaa gcctttgatc aaagcttcag gaaatggctt gatcaataaa aaacagcccg 396181 cagatcaaca tccgcgggct gtttctgatt ataagacccc tttcatcgcg cgtttgatca 396241 ccggcgagag cagcaggaga atgccgccaa gaacgataga aatcaaaccg atggtgccga 396301 agtacattgt ttcaggaatt ttatcaaaca atccggctac ttgggcattg atcgcttggg 396361 ctgctgcgtt cgtcagaaac cacatactca ttgtctgtgc agagaaggca gctggtgcca 396421 gtttcgttgt cacggataaa ccgactggag acaggcacag ctctccaagc acgacaagca 396481 ggaagctgag aacgagccaa agcgggctta cgagtgcttc ttttccttgc atagcaggga 396541 ataccataat gataaatgac aatccggcta aaataattcc gattgagaat ttaactggtg 396601 tagacggctg acgtttgcca agcttcatcc agagccatgc gaatattggc gcaaaaatga 396661 caacaaacaa tggatttaat gattggaacc atgatgactg aagttcgaat ccgcccaatg 396721 aaagtcttat gcgttcatca gcgtataccg caagaatggt cgctccctgt tcctgaatgg 396781 cccagaacat gacagcaccg ataaacaaag gaacgtaagc ggcaagacgg gatttttctg 396841 ttttgtccgc ttttttgctt gtaaacatga tgatgaaata aatcacagga atcaaaatac 396901 cgagaatact tacaaggtca atgaaacgtt tgatcgtcag cacgcctgtt tgtacagaga 396961 taatcactgc gatcgccaca atgataacac cgattccggt gccaattgca gattttttag 397021 acagcggatt cggcacattg gaacctgcaa gcccgaggtt tttctttctt gtcaaagcaa 397081 atacgataag tccgagaagc attccgaccg cggcagctcc gaatccgaga tgatagttgt 397141 acttctgtcc gagtgttccg acaattaacg gcgcgagtaa accaccgagg ttaatcccca 397201 tgtagaaaat actgaaacct gagtcgcggc gcgggtcttc tttcgtgtaa agatccccaa 397261 ctacgcttga aacgtttggt tttaataagc ctgttccgac aatgataagc accatactga 397321 tatagaatgc tatcgaactg cccggatagg cgagtgcaat gtggccgaac ataatgaata 397381 tgccgccgta aaacacggtg tttgcggtac cgaatacccg gtcagcgagc catccgccaa 397441 taatggtgga catgtatacg agtgatccgt aaatcgacat aatggcaacc gcagtgccct 397501 tgtcaaagcc gagccctccg tttaccgtct ctgtatacaa atagtaaagt aagattgctc 397561 tcattccata gtaagagaaa cgctcccaaa attcggtgaa aaatagtgta aatagtcctc 397621 gcgggtgacc aaagaaccct ttttgcggga cgcttttaat gatactttcg ttatcaatcg 397681 aagccatgtc agccaaaccc tttctaaaaa aagtgtatta taaaaatcat attcttatat 397741 aatacttgtg tcaatataat ttatactcat ttcaaatagt tccatattgg aaaaattata 397801 aatacctaaa aatagtgatt tcctcctaat ttttaaactt tttatcgtga gattttctta 397861 cacaactatt cctttatatt tttttaataa aattttagag aaatgtacaa gcagatcggg 397921 aggaccgctg gtgaatcaat cccctgtaac ggggattttt ttatgtccgt aaaccgcttt 397981 gaaaagccgc tgcacaccct cctgaatatc ttcttccttc agccgtgcaa agccgataat 398041 gagagcaggc ctgcccgttt gccgcttgtt ttccttcaag ttaaatcggc tcattccgaa 398101 tatttcaagc tgcagcccgg cagcatgtga caggatgtct tgttcggtgc gcctggtatc 398161 aaattcggta acaaaatgca gccccgcatt tgcccctttt acggtaacct ctccgctgaa 398221 ctctgcttct aaagcggtga tcaggcgttc tctcttttct ttataatgct gcttcatttt 398281 ttttatatgc ttctgatatt caccagactc gataaattcc tgcagggtga gctgtgtgag 398341 tgatgagcaa gtctgcagat catagccccg ctgtttgtat gccctcaaca gctcaggcgg 398401 caacaccata tagctgatcc gtaagccggg gagaagggac tttgaaaagg ttcccatata 398461 gatgacattt tgaaaacggt cgaggctttg cagcgccgga atactgtcta catcatatgt 398521 gaattcacta tcataatcgt cctcaatgat atatcggcgc ggctcctcgg ctgcccagtt 398581 cagcagctga attcttctgg atacaggcat aatcgttccg gacggaaact gatgcgacgg 398641 ggtggtcacc agcacatctg gctgctgtct ggtgatttca gcaatcgaca tgcctttttc 398701 atccagcatg atcgtcttta cttgttttcc ggcattcttc aaaagctgat acatgcgcct 398761 gtagccaggc tcctccatcg catacacggc ttccttgggt aaaagctcag tcaacagctg 398821 catgagcacc tgtgtgcctg cccctatgat catttgttcc ggcctgcatt ttacacccct 398881 cgtcagggaa atgagcctcg taatggccgc tctcacttca tatatccctt gcggatgtga 398941 catatcgccg agcgtgcggt atgagcggga ggccgctttt tgctcgcagc ggaaccagct 399001 tttgatcgga aaatggtctg tatcggaact catgtgtgaa aacgatatcc aatcgctctg 399061 gtcgatgtga atctctttta ggtcatccgg cagtgcaaat ggagggtgct cctcggcgga 399121 aaacatgtct agttcctcca cgaagaaacc ctttcgttca atggcgtaca aatacccctc 399181 agccagcagc tgctgatagg ctgaattcac tgaatttacg ctgaccttga gattttcagc 399241 cagctcccgc ttggagggaa ccttcgagtg cggcagcaga ttgcggctga ggatttcttt 399301 tttcagcttt tgataaattt gctgatagat ataatcggct tgttctgaac gatcgagtgt 399361 aatcgtgata tccattttgt agtttctcct tctgatacca tcaaaaagtt ataattggta 399421 cttttcatca taccaaagag aagtcagaat gataagaaaa taccgacagg gggatattca 399481 catgagtcaa acaacagcaa gcatcacaac tgcacaatgg cagcaaaaac gggatcaatt 399541 tgtgtcaaaa ggtgtgagca acggcaaccg cagtctggcg gtcaaaggag aaggggccga 399601 gctgtacgat ctggatggcc ggagatttat tgattttgca ggcgccatcg gcacgttaaa 399661 tgtcggacac tcgcatccga aggtggttga ggctgtgaag cggcaggcgg aggagctgat 399721 tcatcctggt tttaatgtca tgatgtaccc gacttatatc gaattagcag aaaaactgtg 399781 cggcatcgcg ccgggcagcc atgagaaaaa agcgattttt cttaactcag gggcagaagc 399841 ggtcgaaaac gctgtgaaaa tcgccagaaa gtatacaaag cgccaaggcg ttgtctcgtt 399901 tacacgcggg tttcacgggc gcacgaatat gacgatgagc atgacaagca aggtaaaacc 399961 ttataaattc ggtttcgggc cttttgcgcc agaggtttat caagcgccgt tcccttatta 400021 ttatcagaag ccggccggca tgagtgatga aagctatgac gatatggtca ttcaagcatt 400081 caatgatttc tttatcgctt cagtggcgcc tgaaacggtg gcgtgtgtcg tgatggagcc 400141 agtgcaggga gaaggcggat ttattattcc ttcgaaacgg ttcgtacagc acgtcgcttc 400201 attctgcaaa gaacacggca ttgtttttgt tgctgatgaa atccaaaccg gctttgccag 400261 aactggcact tatttcgcaa ttgagcactt tgatgtagtg cccgatctga tcacggtttc 400321 taaatcgctt gcggcaggcc tgccattaag cggtgtgatc gggcgtgcgg aaatgcttga 400381 tgcggcagcg ccaggggagc tgggcggcac gtatgccggc agcccgctcg gctgcgcggc 400441 ggctttggca gtcttggata ttatcgaaga agaaggactg aatgagcgat ctgaagaaat 400501 tggcaaaatc attgaagaca aggcgtatga gtggaaacaa gaattcccgt tcatcggtga 400561 catccgcaga ctcggggcga tggccgcaat cgaaatcgtc aaggatcctg acacgcgtga 400621 gcctgataag acaaaagcag cagcgatcgc ggcctatgcg aatcaaaacg gattactttt 400681 gctgacagcg ggaattaacg gtaatatcat ccgctttttg acaccgctcg tcatctcaga 400741 cagcctatta aatgaagggc tcagcatctt ggaggcgggc ctgcgagctt aatcattgga 400801 aagaaaatgg ccgggtctgc tatcatttta agtaatcatg aaaagaaagg aatgttcaat 400861 atgccagatc aattaacggt ctacaacccg gctacgggcg aggagatcaa aacgattcct 400921 cagcaatcag ccacagaggt agaagaagcc attgaacgtt cacatcaagc gtttaaaacg 400981 tggtctaaaa catcagcgaa cgaaagaacg tctcttttga aaaaatggta tgagctgatt 401041 gttgaacata aagaagagct tgcagattta attacaaagg aaaacggaaa accataccag 401101 gaagcagtcg gcgaggtact ttacggcgca ggctatatcg aatggttcgc agaggaagcg 401161 aagcgtgtgt acggaagaac ggtcccggcc ccgacaactg gtaaacgaat tgttgtcaca 401221 cgccagccgg tcggccccgt tgctgctatc acgccctgga atttcccgaa tgcgatgatt 401281 acacgcaaag cggcgcctgc tcttgccgcc ggctgtacat ttatcatcaa gccggcgccg 401341 gacacaccgc tgtctgctta tgaactagcg cgcctcgcat atgaagcggg cattccgaag 401401 gatgttcttc aggttgtgat cggcgatgga gaagaaatcg gaaatgtgtt cacaagcagt 401461 ccgaaaatcc gcaaaatcac gttcacaggc tcaacacctg tagggaaaat ccttatgaaa 401521 aacagcgctg acaccgtaaa gcacgtctca atggagctcg gcggacacgc cccgctgatc 401581 gtagatgaag atgcggacat tgaccttgcc gttgaacagg cgatggcgtc caaataccga 401641 aacgccggcc aaacctgcgt atgtgccaac cgcctgatcg ttcatgaatc cattaaagat 401701 gaatttgctg cgaaactgag cgagcaagtg tctaagctga aagtcggaaa tggacttgag 401761 gaaggcgtca atgtcggccc gattatcaac aaacgaggct tcgaaaaaat cgtcagccaa 401821 atagatgatg cggttgaaaa aggcgcgaaa gtgattgctg ggggcacata tgaccgaaac 401881 gatgacaaag ggtgctactt tgtgaatccg acagtgctca ccgatgtcga tacgtccatg 401941 aacatcatgc atgaggaaac attcggcccg gtcgccccga tcgtcacgtt ttctgatatt 402001 gatgaagcga ttcagcttgc caacgataca ccgtatggct tggctgctta cttcttcaca 402061 gaaaactacc gccgcggcat ctatatttcc gagaatctag agtatggcat tatcggctgg 402121 aatgacggcg gaccgtcagc ggttcaagcg ccattcggcg gaatgaaaga aagcggcatc 402181 ggccgtgaag gcggttcaga aggtatcgag ccgtaccttg aaacaaaata tttgtccatc 402241 ggtttataaa agaatgcacg ctcctgagag ctgccggatt ttccggcagc tctttttgtg 402301 ttccggcgaa taatcacaac aattccagcc aaaataacag caaatacatt ttgaaagaag 402361 gttccccaac aatggattta ttattggctc ttctcccggc tttgttttgg gggagcattg 402421 ttctcttcaa tgtgaaatta ggcggcgggc cgtacagcca gacactggga acgacgatcg 402481 gggcactcat tgtttctatc gttatttact tttttgttca gcccgttctg tcccttcgca 402541 tttttattgt tggaatcgta tccggcttat tttggtcact tggacaggcc aaccagttga 402601 aaagcattca attgatgggc gtgtcgaaaa caatgccgat ttccacagga atgcagctcg 402661 tttccacctc gctgttcggt gtgatcgtgt tccgcgaatg gtcaacaccg attgcgatta 402721 cgcttggcgt tctcgctttg atctttatca ttgtgggaat cattctcacg tccttggaag 402781 ataagaatga taaaaaagag ggcgagccaa gcaatttgaa aaagggcatt ttgattctcc 402841 ttgtttcgac tcttggttat ttggtttatg tagtcgtggc tagattattc aatgtgtccg 402901 gctggtccgc gctgctgcca caggcaattg gcatggtggt cggggggtta gttttaacct 402961 atagacacaa accctttaac aagtatgcga tcagaaatat tctcccaggg ttaatctggg 403021 caggcggaaa tatgtttttg tttatttctc agccgcgagt cggcgttgca acgagctttt 403081 ccctttcaca aatgggaatt gtcatttcta cgctcggcgg tattttcatc ctgcgtgaaa 403141 agaaaacgaa acgccagcta atagcaattg cgatcgggat tatcctgatt attgccgccg 403201 ccgtattctt aggaatcgcc aaaacaaatt cataacaaat ggaggaggat gtatatgtat 403261 ccggatttaa aaggaaaagt cgtcgctatt acaggagctg cttcagggct cggaaaggcg 403321 atggccattc gcttcggcaa ggagcaggca aaagtggtta tcaactatta tagtaataaa 403381 caagatccga acgaggtaaa agaagaggtc atcaaggcgg gcggtgaagc tgttgtcgtc 403441 caaggagatg tcacgaaaga ggaagatgta aaaaatatcg tgcaaacggc aattaaggag 403501 ttcggcacac tcgatattat gattaataat gccggtcttg aaaatcctgt gccatctcac 403561 gaaatgccgc tcaaggattg ggataaagtc atcggcacga acttaacggg tgccttttta 403621 ggaagccgtg aagcgattaa atatttcgta gaaaacgata tcaagggaaa tgtcattaac 403681 atgtccagtg tgcacgaagt gattccttgg ccgttatttg tccactatgc ggcaagtaaa 403741 ggcgggataa agctgatgac agaaacatta gcgttggaat acgcgccgaa gggcattcgc 403801 gtcaataata ttgggccagg tgcgatcaac acgccaatca atgctgaaaa attcgctgac 403861 cctaaacaga aagctgatgt agaaagcatg attccaatgg gatatatcgg cgaaccggag 403921 gagatcgccg cagtagcagc ctggcttgct tcgaaggaag ccagctacgt cacaggcatc 403981 acgttattcg cggacggcgg tatgacacaa tatccttcat tccaggcagg ccgcggttaa 404041 acataaaaag cgacccagac atgacatctg gatcgctttc tttattaggc acgctttttc 404101 tttacaagtg ctgctacaga taaaataatg gcagccgcag acagcaccat cgctgtaatg 404161 tctagagctg aagaacctga gttttcggaa tcgtcttctg ttttcgtggc gccgtgctca 404221 tctgtcactt gctttgcaga cgtgatgttt gtaatggaat gaggtgtatc ggcatcctcg 404281 tcacctgtcc actcaacaat gctgccgtct ttgtaatatt ggtatgcgtc ccaagcagct 404341 tcctccgctt tgtcagggtt tttggcaaca aaggtaaact gctggaactg gccttcctga 404401 atgcctccgt cagtcgcctc ccatgtcacg gatactgatt tgtcatcatg tttttgagtg 404461 gaaaccttcc agcccggaat tggctcatat tgctggaatt caacatcctt cggcattttg 404521 aggacaacct tcgttgtcgg cagatttttc tcagaaggaa ccttcattgt atacgtttcc 404581 caagagcctg cagcagactc agccggtttt acagaaacat gcgcgctggc aggggccgta 404641 aagaataaga gggagccgac aatagccgga catagtgtca atgcgatttt tttcaacaac 404701 gtaaacactc cttaattggt ctttgtaaac atgatattga tttcgttaaa gtcgccggtc 404761 aggccgtgga ctttgatctt ccagtttcct ttttcattaa tcgacaggtt ttgatcttgg 404821 aagacgcctt ttgttttttc ttttaatgta aaggtgcttt tgttttcgct gcctgacagg 404881 cctgttttat aaacggttaa cgtgatttgc tggatgtttt tcacgggatc accgttatgg 404941 tcggtgaccc gcagctcaaa aacatttttt ccaggctggt ttgggctgat gctgagagaa 405001 acgctttgtc cgttctctat cgctttggtt tggtagaacg gttccggcgc tggctcaggc 405061 gggcttggca ggcttgtaaa cacggccgct gtgatcaata cagcgatgcc gattgcccac 405121 tccgctttca acgttcggct gattcctgtg cggcgctgct ttctggtaag cagaaaatga 405181 attgcgccta agaccagcat gaaaacaaac agcccgcttt tcactaaaag agcttgtccg 405241 tacgctgtat ggaacagtga atccattgaa cgaatgatga aaaatccatt gagcaagcct 405301 gaaaacaaaa tgacgccgac tgcagtgagc gcccatgggg agaaccgtct gaccgtctcc 405361 cacgcgagcg ttttgtcagg ctgcctccat tcttttgaga gcagcaaaac gagtgccgct 405421 attccgccga cccagatgga agcggaagtt aaatgaagga aatccatcaa aatgccgacc 405481 gttttttctt caacgacagc agcatgcccg gtaaacgcct tggcaagcag gagaccgaaa 405541 aagaaaatga gcggcgctgt ccaatagcca aaggatgaaa agcggttttt ccgtatcgca 405601 gggatgacag acagtgcgag cagcacgaac agcgcagcct gtatgatcca aatggagccg 405661 cctgctgtct caaacagtgt ttctctgatg tagcccggct ggaatgcgct gccccagccg 405721 ccgcctgcgt tcgcttttgt ctgaatcgga agctgaagca aaagcgccag ccccaatgct 405781 gcgatcgagc cggtcaggat acgtctcgtc cgtttgacga gctgttctga tttcccttta 405841 taccagaaaa gatggaagaa aaccgttccg ataaacagag ataaggctgt atacagaatc 405901 gcgcgatctg ctgctgttcc cggattcagc gctgaatcgg ctgctttttg gctgctgaat 405961 ccgccatccg ctttcccgat actgaacgga atgacgccgg aaacaggatg tccatccgcg 406021 gatacggcat tccattccgc tctgtacaca tctttaggca gattcttctt cagcttcact 406081 gtcatgatgt gatgattatc ttttttgatt tcagtcttgt ccgtatccac acggtcgccg 406141 tttgaattat agactttaat gtaatgaaac ccttcttcaa ccggttcatt aaattcgatt 406201 tccacctgcg caggggcgct ttttaattcg ctgttttccc caggtgaaga tttgacaata 406261 taggcgtgag caaagcttgt tttcggcagg aaaacaagaa aaagcagaag gatgatccac 406321 catctgtttc gcttcatcac tcagacacca ccttccgctg tatgtgttgt gttatttctt 406381 ggtgcaggtg cagcgtttct ttcggtcttg aagcatgtct tccagcgctt ggtcgaaagt 406441 gcagacggct ccgccgaatc ctttttgaaa tcgttcggca tggtcaagtg tcgcaaacgg 406501 aatggcctgc ggctggcagc agtgcaggtt taattcagca tttacgacga aataagccga 406561 accggcactg acggttgtct gtaacagaaa atctctgcaa atcaagtgtg aaacctcttc 406621 cgttttatcc gcgtaacgca aaaacgcgca atgtgcgcag catagctgtt caatgtcttg 406681 gtttaccgta atcagctgaa ccgaatgagc ttgattgacg ggcttcaagc aatagctgca 406741 catatgatct gtttgaggtg ttcggacggg gagcgtgatg ccgccggccg ttttaatgac 406801 ctgatttgac tgaaccagct gattgacatc tctatatacc gtcatttccg aaacgccgaa 406861 ccttgcgctg atgtcagaaa ttctaagcga gccttcttct ttcagccact tcagtatgtg 406921 ttgctgtcta ttaatcggaa gcattcatac accctcttca ttaagatcta tttaagcgta 406981 gaggatttta gagacggaga caagtaagtg gatgataaaa aatgtgaaaa tgtgttgaac 407041 agcaacaaaa cgaaacagaa gggactctgg tataatagac agatggaata gaaagtgagg 407101 aataccctat gaaagaaaca ccatgcccga actgcggcaa acctttgaca ggcgatatgg 407161 tcagatcatc aaatgtgcct tgtcaatttc gctgcggcca ctgccgggaa cggctttatg 407221 aatataaagt ttcagctccg attatgctgg tatcattagc ggccatcgtg ctgcttattt 407281 atcttttgat gctcctccgc aatgcggcag gctcagtgct gccagctgta cagcacgtgc 407341 cgatggctgt atttgcgctt gtgtgcgcgt atcccgtttt tattgtgagt gagcggatga 407401 ttgcaaagta cgtgattcaa aatggcaaca tcatttatag aggaaagaga aaaggctcct 407461 gaaaccagga gcctttttat ttttaaaaaa ttgtcacagt catgtgccaa agtcctcttt 407521 actttcaatt gtatagggac tgtaagcgtt ttaacataga gtcaaaggga agcatcattc 407581 tctgaacata tttttgtatc ttacagcgac aaacaaaaca gggagggttt atatatgcag 407641 cagcaagaac agcagcaagg cggcatgaaa gtgaaagtgc aacgctttgg gagttatttg 407701 agcggaatga tcatgccgaa tatcggcgcg tttatcgcgt ggggtatcat taccgcgctg 407761 tttattccgg caggatggtt tccgaatgaa cagctgaaca cgctggtcag cccgatgatt 407821 acgtatttat tgccgctttt gatagcgtat acaggcggaa aaatgatcta cgaccaccgc 407881 ggcggagttg tcggagcgac agcggcaatt ggggtgattg taggatcgga tattccaatg 407941 tttttaggcg caatgattat gggtccgctt ggcggatacc tcattaaaca gactgataaa 408001 ttattcaagg ataaagtcaa gcaaggcttt gaaatgctga tcaacaactt tacggcaggg 408061 attgtcggcg cggctttaac gattctcgcg ttttacgcca tcggcccggt tgtcttgacg 408121 ctaaataaat tgctggcggc tggtgtggaa gtcattgtac acgctaattt actgccggta 408181 gccagtgttt ttgtagaacc ggcgaaagtg ttgttcctta acaacgccat aaaccatgga 408241 atcttaagcc cgatcggaat cgagcaagca tctcaaacag gaaaatcaat tctgttttta 408301 gtagaagcaa accctggacc ggggctcggc attttgctgg cctacatgtt ctttggcaaa 408361 ggatcttcaa aatcaacggc tcccggtgcg gcgatcatcc atttcttcgg agggattcac 408421 gagatttact tcccgtacat tctgatgaaa ccggccctga ttctcgcagc cattgccggc 408481 ggagcaagcg gactcttaac atttacgatc tttaatgccg gacttgtcgc ggcagcgtca 408541 ccgggaagca ttatcgcatt gatggcaatg acgccaagag gaggctattt cggcgtattg 408601 gcgggtgtat tggtcgctgc agctgtatcg ttcatcgttt cagcagtgat cctgaaatcc 408661 tctaaagcta gtgaagaaga cctggctgcc gcaacagaaa aaatgcagtc catgaagggg 408721 aagaaaagcc aagcagcagc tgctttagag gcggaacaag ccaaagcaga agaagcgtct 408781 gagctgtctc ctgaaagcgt gaacaaaatt atctttgcgt gtgatgcggg aatgggatca 408841 agtgccatgg gggcatccat cttaagaaac aaagtgaaaa aagcggagct tgacatcagt 408901 gtgaccaaca cggccattaa caatctgcca agcgatgcgg atattgtcat cacccacaaa 408961 gatttaacag accgcgcgaa agcaaagctg ccgaacgcga cgcacatatc agtggataac 409021 ttcttaaaca gcccgaaata cgacgagctg attgaaaagc tgaaaaagta atcttataga 409081 aagagagtga ttgtcatgca agtactcgca aaggaaaaca ttaaactcaa tcaaacggta 409141 tcatcaaaag aagaggctat caaattggca ggccagacgc tgattgacaa cggctacgtg 409201 acagaggatt acattagcaa aatgtttgaa cgtgaagaaa cgtcttctac gtttatgggg 409261 aatttcattg ccattccaca cggcacagaa gaagcgaaaa gcgaggtgct tcactcagga 409321 atttcaatca tacagattcc agagggcgtt gagtacggag aaggcaacac ggcaaaagtg 409381 gtattcggca ttgcgggtaa aaataatgag catttagaca ttttgtctaa catcgccatt 409441 atctgttcag aagaagaaaa cattgaacgc ctgatctccg ctaaaagcga agaagatttg 409501 atcgccattt tcaacgaggt gaactgacat gatcgcctta catttcggtg cgggaaatat 409561 cgggagagga tttatcggcg cgctgcttca ccactccggc tatgatgtgg tgtttgcgga 409621 tgtgaacgaa acgatggtca gcctcctcaa tgaaaaaaaa gaatacacag tggaactggc 409681 ggaagaggga cgttcatcgg agatcattgg cccggtgagc gctattaaca gcggcagtca 409741 gaccgaggag ctgtaccggc tgatgaatga ggcggcgctc atcacaacag ctgtcggccc 409801 gaatgtgctg aagctgattg ccccgtctat cgcagaaggt ttaagacgaa gaaatactgc 409861 aaacacactg aatatcattg cctgcgaaaa tatgattggc ggaagcagct tcttaaagaa 409921 agaaatatac agccatttaa cggaagcaga gcagaaatcc gtcagtgaaa cggtaggttt 409981 tccgaattct gccgttgacc ggatcgtccc gattcagcat catgaagacc cgctgaaagt 410041 atcggttgaa ccatttttcg aatgggtcat tgatgaatca ggctttaaag ggaaaacacc 410101 agtcataaac ggcgcactgt ttgttgatga tttaacgccg tacatcgaac ggaagctgtt 410161 tacggtcaat accggacacg cggtcacagc gtatgtcggc tatcagcgcg gactcaaaac 410221 ggtcaaagaa gcaattgatc atccggaaat ccgccgtgtt gttcattcgg cgctgcttga 410281 aactggtgac tatctcgtca aatcgtatgg ctttaagcaa actgaacacg aacaatatat 410341 caaaaaaatc atcggtcgct ttgaaaatcc tttcatttcg gacgatgtga cccgcgtagc 410401 gaggtcacct ctcagaaaac tgggagaaaa tgatagactt gtaggcccgg caaagaaaat 410461 aaaagaaccg aatgcactgg ctgaaggaat tgccgcagca ctgcgcttcg atttcaccgg 410521 tgaccctgaa gcggttgaac tgcaagcgct gatcgaagaa aaaggataca gcggcgtact 410581 tcaagaggtg tgcggcattc agtcccatga accgttgcac gccatcattt taaagaaact 410641 taatcaataa ccgaccaccc gtgacacaat gtcacgggct ttttttacta tctcgcaatc 410701 tagtataata gaaagcgctt acgataacag gggaaggaga atgacgatga aacaatttga 410761 gattgcggca ataccgggag acggagtagg aaaagaggtt gtagcggctg ctgagaaagt 410821 gcttcataca gcggctgagg tacacggagg tttgtcattc tcattcacag cttttccatg 410881 gagctgtgat tattacttgg agcacggcaa aatgatgccc gaagatggaa tacatacgct 410941 tactcaattt gaagcagttt ttttgggagc tgtcggaaat ccgaagctgg ttcccgatca 411001 tatatcgtta tgggggctgc tgctgaaaat ccggagggag cttgagcttt ccattaatat 411061 gagacccgcc aaacaaatgg caggcattac gtcgccgctt ctgcatccaa atgattttga 411121 cttcgtggtg attcgcgaga acagtgaagg tgaatacagt gaagttggcg ggcgcattca 411181 cagaggcgat gatgaaatcg ccatccagaa tgccgtgttt acgagaaaag cgacagaacg 411241 tgtcatgcgc tttgccttcg aattggcgaa aaaacggcgc agccatgtga caagcgccac 411301 aaagtctaac ggcatttatc acgcgatgcc gttttgggat gaagtctttc agcagacagc 411361 cgctgattat agcggaatcg aaacatcatc tcagcatatt gatgcgctgg ccgctttttt 411421 tgtgacgcgt ccggaaacgt ttgatgtcat tgtggcgagc aacttgttcg gtgatatttt 411481 aaccgacatc agctcaagcc tgatgggaag catcggcatt gcgccttctg cgaacatcaa 411541 tccatccggc aaatatccgt ccatgtttga accggttcac ggctcagctc ctgacattgc 411601 cggacagggc cttgccaatc cgatcggcca gatttggaca gcgaagctga tgctcgacca 411661 cttcggagag gaagaattgg gggcgaaaat tctggatgta atggagcaag tgactgccga 411721 cggcatcaaa acacgcgaca ttgggggaca aagcacaacg gctgaggtca ctgatgaaat 411781 ctgttcgcgc ttaagaaagc tctgatgaat caggccggtg gcagatggct gccccggcct 411841 gtccatttcc ttacgaaaat ttccacgaaa gtctaaccaa gcagatccaa atgctgtata 411901 ataatttgga attcttagga aagcatcggg tgaaggaagt tgaatgcaaa aacaatcacg 411961 ttaaagaaaa aaagaaaaat caaaacgatc gttgtactca gtatcattat gatcgcagct 412021 ctcattttta cgatcagatt ggtgttttac aagccttttc ttattgaagg atcatcaatg 412081 gccccaacgc ttaaagactc agaaagaatt ctggttgata aagcagtcaa atggactggc 412141 gggtttcaca gaggagacat catagtcatt catgacaaaa agagcggccg ctcatttgtc 412201 aaacgtttaa tcggtttgcc tggtgacagc attaaaatga aaaatgatca gctatacata 412261 aatgataaaa aggtggaaga accatactta aaggaatata aacaggaggt caaagagtcg 412321 ggtgtaacct taacaggtga cttcgaagtt gaggttcctt ccggtaaata ttttgtgatg 412381 ggagataacc gtctcaattc actggatagc agaaacggaa tgggcatgcc ttctgaggac 412441 gatatcatcg gtactgaatc tctcgtcttt tatccattcg gtgagatgag acaggcaaaa 412501 taaaatgcaa tgcaaaaaga acatggaaca tgacggcacc gataataaag cgccgtgcac 412561 gtttaaaaaa atgatgatga aacggtgcgg agccggcttt ccgccccgtt ttttatgata 412621 gaaagcgttt tgaagaaaag ggccctgttg aaataaacag aatcaggatt ggcgaagccg 412681 tgaagcgcat cgaattggta aatctcaaga tgggtatgct gtttttcccg cagttttttg 412741 ataagaagcg ctacgtcaaa cgacggctca taattaggga aaaacaatag gaccgggcag 412801 gctggcatgt gatgaagaga gtcgcgtatc cgggaaccgt aataacaaac cgatccgctc 412861 acctcaggca tactgctgca tttccatgcg atagtagccc ccacgctgaa tccaatcaca 412921 aagatgtgcc gtccggcgtt ttgcctgatc acattctgga tgatggtttc tcccgttttc 412981 agcctttcgt gttttgtaaa ttgttcgtat gccgtttttt cttctttcag tgtgtagact 413041 tcatcctcgc cgagcaggtt gggcgtcaac acatcatatc cagccatttt gatcagccgg 413101 cccatctttt tcatatggct gtttacacca tatatttcgt gtgcgagaat gacaagcggt 413161 tttgggaaca taacggcctc cttttgtgtt ttttccatta tatcctatcg tttcacttta 413221 ggctgagata taatggtcaa aaaaaggaga tataaaatga actcattatc tttgcctcac 413281 cgctatccat ttttgtttat tgatggcgtg acggatagcg agcccggcaa acatgcggca 413341 gcttataagc tgattagtga gaacgactgg tttatcactg atacgcaaac agaaatgccg 413401 ttttcacttg tgattgaagc gcttgcgcaa accgcggctt ttacaggaat tacagatgag 413461 aacagcttgg gattattgtc ttcggtgaag aaagcggaaa agctgggaga agctgtgcct 413521 ggtgaccggc ttgatcttac gtttgaagtc acgcgcaatc ggcgcgggtt tgtgttcgga 413581 catgccaagg catcagttgg agagcagcct gttgctgaag ctgaaatcgg catctatatt 413641 gaaaaatgaa aaaaaccctt cacaacattt tgtgaggggt tctattttgt gtcgtaatcc 413701 cgttcgcttt gagagttatc tctttgctgg cgtttgtgtt tttcatcatt catattttcc 413761 ttcagctctt cattaggaat cggatcggtt aagtcgttgt gctcggggtt ttcatttggt 413821 ttgttttgct gttttttttc tgtcatgttt gatcacctca ccgtttgttt tcctcttatt 413881 cattctcctc aaacatagga aatcgctttt ttgtcccgct gggtataatg tattagaata 413941 gagagaagca caacaaaaag ataaagagag gtacatatat gtctgttcaa agagaagatg 414001 tagatatcaa gctgatcgca attgatatgg atggtacact gctgaacgac gagcagctga 414061 tctcggatga aaaccgcaaa gccattcgtg aagcggagga taaaggtgtg tatgtggtga 414121 tcagcacggg ccggacgctg atgacgtgca gggagctggc ggaatcgcta aagctgtcat 414181 cctttctaat cacggcaaac ggcagtgaaa tttgggattc gaattttaat ttggtggaac 414241 ggaagctgct tcatacggac catattcaaa tgatgtggga tttgcggaat aagcacaaca 414301 ctaatttctg ggcttctacg gtgaataaag tatggagagg cgagtttccg gaaaacatta 414361 cggatcatga atggctcaaa ttcggctttg acatcgagga tgacgatatc cgaaacgaag 414421 tgcttgagga gctgagaaaa aacaaagagc tcgaaatcac aaattcaagt ccgacaaaca 414481 ttgaagtcaa cgcgcttggc atcaacaaag ctgcagccct tgccaaggtt acggaaaaac 414541 tcggctttac aatggagaat gtgatggcga tgggcgacag ccttaatgac attgcgatga 414601 tcaaagaagc gggtcttggc gtcgcaatgg gcaatgcgca agacatcgta aaagaaacgg 414661 ctgattatat cacggataca aatattgagg atggtgtcgc taaagcgatt cgccattggg 414721 tactataaaa aaagagagtc ctaagatgga ctctcttttt tagtttggca ggttttattc 414781 tgggaccatg gtaggttttc tgacaaaagt atttcacaaa ctgatatgat tcacttataa 414841 tgaaataaag ttcaaaaatt cggaatagtc gttccgaatt tcgggacaat aaatgacata 414901 aagcatatcg tttgctttgg caggagggat tctgtgtttc agattgattt aaactgtgat 414961 ttaggagaaa gcttcggagc ctacaagata ggccttgacc aagatatttt agagtatgtg 415021 acatcagcga atatcgcatg cggatttcat gcaggagatc ctagtgttat gcgaaaaacc 415081 gtcgcgcttg cagcagaaag aggcgtgaaa atgggtgcgc atccgggctt gccggattta 415141 ctcggttttg ggcgccgcaa tatggcgatt tctcctgagg aagcgtatga tcttgtcgtt 415201 tatcaaattg gcgcgctctc tggctttcta aaagcagagg gacttcacat gcagcacgtc 415261 aagccgcatg gcgctttata caatatggcg gcagtcgatc aaaaactgtc ggatgctatc 415321 gcgaaagctg tctataaggt tgatcccggc ctgattcttt tcggtcttgc tgagagcgag 415381 cttgtaaaag cgggagaacg gatcggactt cagaccgcaa atgaagtgtt cgccgacaga 415441 acataccaat cggacggcac gctgacaccg cgctcccagc cggacgcact cattgaaagt 415501 gatgatgccg ccgtcaccca ggtcatcaaa atggtgaaag aaggggcggt caaatctcag 415561 caaggacatg atgtgtcatt aaaagcagat acagtctgca ttcatggaga tggagcccat 415621 gcgctgacat ttgcgcaaaa aatcagaaaa cagctcaaag cggctggaat tgaagtgaca 415681 gctatttcag aacagaggtc aacataaagg aggaacaata gatggagcag cagaaaaaga 415741 cagcaggaaa aaaagcgggc agctggtcat tgctgatggg cgccgccttt ttaatggcga 415801 catcagcaat cggaccgggt ttcctcaccc aaaccgcaac attcacaaac acactcgcag 415861 caagcttcgg ttttgtcatc ttaatctcta ttattttaga tattttcgcc caaaccaatg 415921 tgtggcgcat catcgcagtt tctggaaaac gaggtcagga aattgcgaat atggtgcttc 415981 ccggactggg gtatttcatc gccattctcg tcgtgcttgg cggactagct tttaatattg 416041 ggaatatcgg aggggccggg ctgggacttc aggtgctgtt cggcattaca cctgaaacag 416101 gcgctttaat cagtgccgtt atcgccattt tgatttttgt catcaaggaa gcaggaaaag 416161 cgatggaccg ttttacgcaa atcgcggggt tcgtgatgat tattttaacg gtctacgttg 416221 cggcgacgac agctcctccg gtcggacagg cagtcgcaaa tacattcgtc ccggaacaca 416281 tcagcatatt tgccattgtc accctagtgg gcggaaccgt cggcggttat atcacatttg 416341 ccggaggaca ccgtttgctt gatgccggaa ttaaaggaaa ggaatccatt ccgcaggtga 416401 caaagagctc ggttgtcggc attttaatta catctgtcat gcgtatcgct ctttttcttg 416461 cggttctagg cgttgtatcg aaaggcctgc acatcgatga aagcaacccg gcggcttctg 416521 tcttcaagct ggctgctgga aatgtcggtt ataaaatttt cggattgatc atgtggtctg 416581 cggcgattac gtctgttatt ggagcagcct atacatctgt ttcatttttt aaaacctttt 416641 ctccaaaaat tgaaaagaat tcacgcggta ttattatcgg atttattgtg gtttctacgt 416701 tagcttttgt cacaatcggc cagcctgcga agatcctcgt ccttgtcggt tcactgaacg 416761 gcttaattct gccgattgcg ctcggaacgc tgcttgttgc cgcctacaag aaaaacattg 416821 tcggtgatta taagcatccg ctttggctga caagcacagg cgcgcttgta gtgattgtaa 416881 tggcagttat gggaatctac acgttatgta cacaacttcc tcaattgtgg agctgatata 416941 agtggagcaa ttaaacaaaa tggcgccaaa ggatgtacgc gccctgatac gagaggggaa 417001 aataaacggg ccgaccgcag gcatgtccgg cggctacgcc caagcgaatc ttgtggtttt 417061 gaaaaaggac cttgcgtttg attttctgct gttttgccag cgaaatcaaa agccctgccc 417121 cgtgctggat gtgactgaag caggttcgcc tgtgccgtct ctggctgcgc cggatgctga 417181 tatcagaacg gactttccga aataccgtat ttacaggcac ggtatcctaa cggaagaagt 417241 atctgatatt acgccatact gggaggacga ttttgtcggc tttctgatcg gatgcagttt 417301 ctcctttgaa caggcactga tcaataatgg gatagctgtc cggcatattg atgaggggac 417361 aaacgtctca atgtataaaa cgaatatcga ttgtgttccg gcgggggcgt ttcacggaca 417421 gatggttgtc agcatgaggc cggttcctga acggctggct gtacgtgctg cacaagtgac 417481 ctcgcgtttt ccggctgtgc acggagggcc gatccatatt ggcaatccgg gagcaatcgg 417541 gattcgcgat ctcgggaaac cggatttcgg agatgccgtt tccattcgtg acggcgaggt 417601 tcctgttttt tgggcatgcg gagtgacccc gcaagccgtg gctatgaatg taaagcctga 417661 aatggtcatc acacatgcgc cggggcatat gctcatcaca gatattcgag acgagtcgct 417721 tgcggtgctg tagcctctcg tcatcctgat gaacgagaat taaaagaggt gagaaagatg 417781 actgtacgat atcaaatcga acagctcggt gattctgcaa tgatgatccg attcggagaa 417841 gaaatcaatg aacaggtcaa cggcattgtc catgcagcgg ccgcttatat agaagaacag 417901 ccatttccgg gattcattga atgtatcccg gcttttacaa gtctaaccgt attttatgat 417961 atgtatgaag tgtacaagca tttgcctcaa ggcataagct caccttttga gagtgtcaag 418021 cgcgatgtcg aagagcggct ggcagaaata gccgaagact atgaggtcaa ccgccgtatt 418081 gtagaaattc ccgtttgcta tggcggtgaa ttcggtccgg atttagaaga ggtggcgaag 418141 atcaatcaac tgtcaccgga ggaagtaatc gacattcata caaacggtga atatgtggtg 418201 tatatgcttg gcttcgcgcc cggttttcct tttctaggcg ggatgtcaaa acgcattgca 418261 gctccgagaa aatcatcgcc aagaccgtcg attcccgcag gttcggtcgg tattgcggga 418321 ttgcagacag gcgtttatcc gatttcaacg ccgggcggct ggcagctgat cggcaaaacg 418381 ccgctggctc ttttccggcc gcaggaaaac ccgccgacat tgctgcgggc gggagatatt 418441 gtgaaattcg ttcgcatctc agaaaaagac tatcacgcct ataaggagga gtccaattga 418501 gcatgaaagt attaaagccc ggactgctca caacggttca ggatataggc agaacgggtt 418561 accaaaaata cggcgttctg gccagcggcg ctatggacac ggtttcactg cgcattgcca 418621 atctgttgat aggaaacggc gaaaatgaag caggtctcga aataacgatg atggggcccg 418681 gtccgtcgtt tcatttttca aaacagacac tgattgctgt gacaggggcg gacttcacgc 418741 tgcgtattaa tgacgaggaa gcgcctttat ggaagcctgt gctcatcaag gaaaacagca 418801 cggtcagctt tggcccctgc aaactcggca gccgtgctta tttggcggca gctggcggca 418861 ttgaggtgcc tgccgtcatg gaaagtaaaa gcacatacgt cagaggaagc attggcggac 418921 ttcatggcag agcgcttcaa aaagaagatg aactgaacat tggagagatg tcagctcttt 418981 cgcaaaccat cctttctcgc ttaagttcgc agcttggaaa acagggattt gcagcaccga 419041 agtggtcagt cagccgcggc agatttctgc cattgaagaa gaatcccgtc attcgggtgc 419101 tggaaggaaa gcaatttgcc tttttcacag aagaatcaaa aacgcgtttt tatgaagaag 419161 catttcgtgt cacgccgcag tccgaccgta tgggctacag gctcaaagga gaaccgctcg 419221 aactgaaggc cccgcttgag atggtgtcgg aagcggtttc attcggaaca gttcaggtgc 419281 cgcctgacgg caacccgatt atcctgcttg cagaccggca gacgactggc ggctatccga 419341 ggatcgcgca catcatatcc gctgatcttc cgattgtttc ccaaatcatg ccgggcgagc 419401 acgttcagtt tgagcctgtg tccctccagg aggcagaagc gcttgcggta gaacgggaac 419461 agcatataaa agaactgaaa acgagaatga agatggaatg gctgacatag caaaggggat 419521 gaatgatgca gaataaaaat aaaaccgtag tcaaatctat ggcgctgctt aatttgtttt 419581 tgcataaacc aagcctaacc ttaagtgaac tggtgtcgct gacgggaatg ccgaagacct 419641 ctgttcaccg gatggtcagc tccttggagg aaatggggtt cctcagtcgg gatgcgtccg 419701 gcgcttattc gctgggattg gtgtttttgg aattcggaca gcttgtcgct gacaggctgg 419761 atatcagaaa aatagcgaaa ccggtgatgg aagagctgtg ccgggaagtg gatgaggccg 419821 tgcagttgat catgagggac ggcaatgaag cgatatacgt tgagaaaata gaagggacac 419881 agactgtgcg gctgtatacg gcgatcggca ggcgttcccc cctatacgcg ggagcgtgcg 419941 ccagaagcat tctgtccttt cttccccgtg aagaaatcga agcatacatc aaacaaaccg 420001 agctcatttc gattggctcc ggaacgatta ccgatcccga aaaactgctt caggagattg 420061 atgcctctgt gcaaaatggc tatactgtca gctattcaga gctcgaaaac tatacggcgg 420121 cgatcggcgc cccgatcttt aaccatgagc gccaggtggc agccggcatt agcattgcag 420181 gctttgaagc gagatttaca gaagacaggc tgccctattt aacagaaaag gtgaaggacg 420241 ccgctttaca gatttcaaga aaaataggat atacataagt agccaatctt ttctctgctg 420301 cgtacattaa cgtatcgacg ttcaagagtg gaggaaagaa catggtgctt cgatatacag 420361 ctctgggcga ttccttgacg acagggagag gctccgggct gttttcaccc ggcttcgtcc 420421 agcgttttgg ggacatgatg gaagctgact tgaaaacaag aacggcaata aacatatttg 420481 ccagatcagg tctgaataca gaagagattt tgggactcct gtcatatccc tatgtgcaaa 420541 aatgtattcg agatgctgat atgataacga tcacagggtg cggaaacgat ctcatcgatt 420601 cggtcttagc ctaccaaacc tctaaggatg aaacgatttt cagccgtgta tccgcccatt 420661 gccatgagaa ttttgaaaag atgattgcca aagtcgccga gattaaagga gaaaatcctt 420721 ccccgtacgc cattcgtgtg ttcaacttat acaatccgtt tcccgaaatt gatatcgccg 420781 gcaaatggat cacttcgttt aattcacatt tagaaacact tgcatcagca ccccatgtca 420841 aaatcgcgga tgcctatagc atcttcaaag gcaaagaaca ggaatatctg tcctttgacg 420901 gtgtccatcc gaacagcaaa ggctatcaag cgatggctga agccgttcac aagctaggct 420961 ataaagaatt atcagtttca tagaaaacgc gcctcatgac aggcgcgttt tttatgtgtg 421021 atcgaaatat taaaagaaac ttaaaattct ctgtcttctg ttctacagac aaacaaagtg 421081 cgctagaata atggagggcg taggcaaata tagccataac gttcaatatt tcgtatataa 421141 ggaaggatgg tccttttgtt tcggattttt aaaatgtctt ttgcggttat cattattata 421201 ctggcgctta ttgcttttaa ctatacggaa cacacctctg taatccaatc ggtcatgctc 421261 gtctttcttg gtgcggtcat gtttatgcag gggcttgaag agcgcaaaaa agaaaatgac 421321 ggctcaggcg cttttaatat ttataccgcc gtttttgtat ggtctgtctc ccttatcggt 421381 tttacacttc atattatata aatctattac acatcctgaa aatgctcgac cgtcgggaac 421441 ggggtataga accgatgaag caaggctttc cactcttgat actctgaaga accgcgaaag 421501 ccttccgtat ggtcctcaag tgtttcccac tccacaagaa gcagatattt atgcgtttcc 421561 tccatgcatt ttgataacga gtgagtgata tagcccttca tgccggaaat aatcggcgca 421621 gcttgccgga atgcatcctc aaactcttgt tcaaggcctt ctttaatgtg aagcattgct 421681 gcctctctga ccatgctatc ccttctttct gtcttttcaa atagtctaca gcaaacgata 421741 ggagatttct gcaaaatcgg tgaacttttc cttcattttc aaaaaaatct tgcacgcacc 421801 aattcaatta agagaaaata acaagtggaa ggcaggggaa agtcatgtta aaaaagtgta 421861 ttctactagt atttctatgc gtcggattga ttgggttaat cggatgctcc aaaacagatt 421921 caccagagga tcgcatggaa gcattcgtga aacagtggaa cgatcagcaa ttcgatgaca 421981 tgtatcaaag cctgactaaa gatgtcaaaa aagaaatctc caaaaaagat ttcgtcaaca 422041 ggtataaagc catctatgag caggccggcg taaaaaattt gaaagtcact gcgggagaag 422101 tagataagga cgatcaagac aacaagacga tgaaacatat cccgtataaa gtcagcatga 422161 acacaaatgc cggcaaagtc agcttcaaga atactgctgt gctgaaatta gaaaaaacag 422221 atgacgagga gtcatggaat atagattggg acccatcgtt tattttcaag cagctggctg 422281 acgacaaaac cgtgcaaatt atgagcattg aaccgaaacg aggccaaatt tacgataaaa 422341 atggaaaagg cttagccgtc aatacagatg ttccggaaat tggaattgtt cccggagagc 422401 ttggcgataa aaaagagaaa gtcataaaag aactcgccaa aaaacttgat ttgactgaag 422461 acgacatcaa gaaaaagctg gatcaaggct gggtaaaaga cgattcgttt gtgccgctca 422521 aaaaggtcaa gcctgaccag gagaaattag tttctgaagc gacgtcatta caaggcgtaa 422581 caagaacgaa tgtcagctcc cgctactatc cgtatggcga aaagacagcc catttgacag 422641 gctatgtccg cgccattaca gcggaagaac tgaagaaaaa gaaagaagga acgtacagcg 422701 atacgtctaa catcggtatc gccggacttg aaaatgtgta tgaagacaag ctaagaggca 422761 caactggctg gaaaatctac gtgccgcaaa ccggggaagt catcgctgaa aagaaagcaa 422821 aggacggcga ggatcttcac ctcacaattg atatcaaaac gcaaatgaag ctgtatgatg 422881 aactgaagga tgacagcggg gcggcagtcg cgctgcagcc gaagacaggc gaaacactcg 422941 cccttgtcag cgcgccttcc tacgatccaa acggatttat tttcggctgg agcgataagg 423001 aatggaaaaa gctaaacaaa gataaaaaca atccgttttc agcgaaattc aataagacat 423061 acgcgccagg ttctaccatt aaaccgattg cggctgctat tggaatcaaa aacggcaccc 423121 ttaaagccga tgagaagaaa acaatcaaag gcaaggagtg gcaaaaagat tcaagctggg 423181 gcggctattc agtgacacgt gtgtctgaga gacttcaaca agtcgatttg gaaaacgccc 423241 ttattacgtc agacaatatt tattttgccc agaatgcgct tgatatggga gcggacacct 423301 ttacaaaagg cttgaagaca ttcggttttt cagaggacgt tccgtacgaa ttcccgatcc 423361 agaaatcgtc tattgcaaat gacaagcttg attcagacat tttgcttgcg gatacaggct 423421 acggacaagg gcaaatgcaa atgtctccgc ttcacttggc aactgcttac acgccatttg 423481 ttgacaatgg agaccttgtc aaaccgacgc tgatcaaaaa agattcacaa acagctgatg 423541 tttggcacaa gcaagtggtc acgaaggaag gagcggcaga cattacaaaa ggtctgaaag 423601 gcgttgtgga agatgagcgc ggatcagcgt atcagcctgt cgtgaaagga atcacagtgg 423661 ctggaaaaac aggaacagcc gagctgaaaa catcaaaaga tgataaagac ggcacggaaa 423721 atggctggtt tgtcggctac gattacgaaa acaaagacct gcttgtcgcc atgatgatcc 423781 aaaatgtgca ggaccgcggc ggcagccact atgtcgttga gaaagcgaaa aagcaatttc 423841 aatcgaatta aaatgtcttt ttaaaaggag cgaaaggaaa aaggggatct gaggccgaat 423901 gaactagtaa gggggcaaaa cccggtttat acaaagaaaa gagggatttt gcatgcagcg 423961 tattcaattg gcggaggatc ttcaattttc aagagtcata cacgggcttt ggcggctgaa 424021 tgaatggaac tattcagatg ctgaacttct aagcctcatt gaatggtgta tcgatcacgg 424081 catcacgacc tttgatcatg cggatattta tggaggctat acgtgcgaaa agctgtttgg 424141 aaacgccctt gccctttcgc ctggattaag agaaaacata gagttggtca caaaatgcgg 424201 tatcgttctt gaatcgcctg aacggcccgc tcacagatcg catcattata acacaagcaa 424261 atcgcatatt ttggcatccg ttgagcaatc gcttatgaac cttaggacgg attatatcga 424321 tatgcttttg attcacagac cggacccgct catggatccg gagggggtag cagaggcgtt 424381 tcaggccttg aaatgctctg gcaaggtcag gtactttggc gtttcaaatt ttaaagatca 424441 ccagtatcgg atgctggaat catatttgcc tgagaagctc gtaaccaacc agattgagct 424501 ttccgcatac gaattagaaa atatgctcga cggcactttg aacctgtgcc aggaaaaacg 424561 gattccgccg atggcttggt cgcctctggc aggcggcaaa gtattcactg aaaacacgga 424621 taaagaccga cgtgtccgta cggcgcttga atccgtccaa ggggaaatcg gcgccgcttc 424681 attggacgag gtgatgtacg catggctgta tacgcatccg gccggcatca tgccgattgt 424741 cggaagcgga aagcgcgagc ggatttccgc cgcgataaat gcgttgtcat acaagcttga 424801 ccaggatcaa tggttccgca tttttacagc cgtacagggt tacgatattc cataaaaagc 424861 atcagtttac cagctgatgc tttttcaata ttgtcacacc gcttagtgcc aaattaccat 424921 ttataagtga ttgattcttt cttgaaagcg ttttatatta aaaggaaacc tctctatatc 424981 ctctactgca tctccttgcg acttcatccg cacatcaaga ttggctagga ggtctttttt 425041 atgtatatga ctgccagaga acaaaagctg ttaaagcact tattattaca aaacagatat 425101 ataaccgtaa ctgagcttgc tgagctgatg caagtcagca cgagaaccat tcacagggaa 425161 ctcaaatcaa ttaaaccgct gatggaaacc gtggggctta cgttagataa acagcccggt 425221 aaagggttga aagcagtggg aagtcccgag ggtaaacaaa agctgcttac tgatttatca 425281 tatgaacagc atgaatacag cgccgacgaa cggaaactgc tcattctttg ttcgttatta 425341 gagtctcagg agcccgtcaa actgtacacg cttgctcatg atctccaggt gacgaatgcc 425401 acggtcagct atgacttaga tgagctcgag aagtggattt ctccctttgg actgacactg 425461 atccgcaaaa gaggttttgg catccagctc atagggccgg agaatgcgaa acggaaaatt 425521 gtcggcaact tgattgtgaa ccgtctcgac atccaaatgt ttttggaagc ggttgaatta 425581 aacatcaaag gaaaaaccga ttcttcagag aaaatgttcg gggttgtcag caaaggtgag 425641 ctgttaaaaa tggagcgcat cttatttcag ctcaaagaaa aaatcgcttt ttcattgtcc 425701 gacagctcct atatagcgct cgtcgtccat ctgacgtatg cgatcgaacg aattaagctt 425761 ggggaaacta tcaccatgga gcaaaatgag cttgaggaac tgatgaatgc gaaggaatac 425821 agctccgctc ttgaaatcgc gggcgagctt gaacgtgcct tcggcgtgac gattccagag 425881 gcggaggtcg gctatattac aatccatctt cgaagcgcca atcgaaaata caaaacagaa 425941 tacaaagcgc aggaaattga gctggaaaca gccctgcaaa caaagcggct cattgctttt 426001 atttcagaca aaatcagaat ggatctgacg aaaaactact ctttatatga aggcttgatt 426061 gcccatttgg agccggccgt cagccgcata aaagaaaata ttgagatata caatccgatg 426121 aaggaacaga tcaagcgcga ttattttctg ctttatatgg cgatcgaaga aggtgtcgaa 426181 aagtattttc cgggcatgtc cttttctgat gatgaaatcg cttttatcgt tcttcacttt 426241 ggctcggctc ttgaaatcaa aaaagaagaa gcaaaagtga aagcgcttgt cgtctgctca 426301 agcgggatcg gctcctcgaa aatgcttgcc tccagactga aaaaagagct gccggaaatt 426361 gaatcgtttg atatgtcatc tctgatcgag ctaaagggga aggatgttca agcctatgat 426421 atgattgtgt ccactgtacc gattccttat gaaaacattg attacatcat ggtcagccca 426481 ctattaaatg aggaagacgc aaaccaggtc aagcagtata tcaagcggaa gattcccctt 426541 attcttaaca aaaaaagaag ctcgaaggaa gaggcgcagc aagctgatgt acctgacatg 426601 ctggaggcgg cggaaagcat agggcggtat atggaagtta tccaagatgt tctgcgccat 426661 tttacgctag ctcaactcaa aacaaacccg gaccatagca tgcttctgct agagcttttt 426721 caacagctga agaaggatgg cctgatccgt gatccggaaa aagccgcggt ttgcctggct 426781 gagcgggaga aacaaggggg attgggaatc cccggaacaa acatggcgct ttatcatctc 426841 aaaaatgatg aaatcgtcct gccttttttc aaaatgtttg atctcagcac cccctatgaa 426901 gtggatggca tggacggaaa taccctcagg atgacacgca ttctcgtcat gatggcgcct 426961 ggctcattat ctgctgaagg ctcggagatt ttaagcgcga tcagctcggc aattatcgag 427021 agcggagaaa gcatggcggg gtttcaggaa gaaggaggac aagaattgta tcagcggtta 427081 aaccgcatat ttttcacatg gatgaaagaa aaaaacatac tgtaaacctg catggcacac 427141 gtcaaaaatt tggcgtgtgt ttttctgtgg atggggaaca aaataagaaa atgtgggact 427201 attttatcat tcagtattgg aataattcca aaatgaaata gttttacaag ttatcttttt 427261 tgggttaaaa tgggtgaggt aaggaagaaa atctaacaaa ttattgaaga ttcaagagaa 427321 tataggagat gacgatatgg aaacattaca gcatctgatt ctgcatgaca tgccgaatag 427381 cgaagaaata gaggctgtaa aaagcggaga ccatacactg acatataaag gttaccgtaa 427441 acggattaat cagctggcga atgccatgct tcaaaaagga attcaaaagg gcgaccgtgt 427501 tgcattgctt tgcaaaaacg gccatcccgc ctcaactgtt atgttcgccg cacttgaaat 427561 aggtgctgtt gtcgtacctg tcagctggca gctgaaacca tatgaaatga caggcatttt 427621 aaaagcaagt gaaccaaaag cgatgtttta cggagcggag tttaaagaga tactggatga 427681 agttcttcct gaattgtcct cactgtgtgt aacaatggaa acaggaacag cttacgaaac 427741 atctgctgaa tttgaagcgc tgtttgcagg tcctgatcat ttgccagaga cggaaatggt 427801 ttcacctgat gatacagcac ttctgatgtt tacatctgga acaacgggaa acccgaaaag 427861 atgcatgatt acacatggcg gcatatacag atacgttaaa aaatccaaca gctcaatagc 427921 acgtatgaag ggccttcgtt ttctcgcgtg ccatccgatt tatcatacga gtgcgctcat 427981 ttgcatcatg cttggaacgt ttgcagaaac aacatttgtg tttacaaagg atcaagatcc 428041 tgttcacatg ctgaaggtca ttgaagaaga gaagattcag accgtgatgg ctcttcctgt 428101 gttctacacg tatttgcttg aggcgtggga aaagcaccaa actgacttat cttcgcttgt 428161 tattttaatg acaggcggaa caaaagtgcc gagcagccta ataagccgct atcttgatat 428221 tggcattccg cttgcgcatg gctatggaag tactgaggct tggggcatca gcacatggac 428281 gcctgatatg ggaatggata aagcggcatc tgcaggaaaa cctgtggcag gtgttaaagt 428341 caaagtggaa gatcctctga ccggagaaga acttcctcaa ggagaaatcg gcgaaatcgt 428401 tgttcatact ccattcttat ttaaaggcta tgaagacaat cctgaagcaa cagcgaaagt 428461 gctgcaaaat ggatggttta gaaccggaga ttcaggatat gtagatgaag atggctttat 428521 tttcatcacg ggacgctaca aggatgtcat tatttacgga ggcgataacg tctatcctga 428581 tcaggttgaa gaagttatcc agcagatccc gggaatcctt gaaacggctg tggtcggtat 428641 tcctgacccg ctttacggtg aaaaaccgaa agcttttatc gtgaaaaatg gcggccagcg 428701 catcacggaa gaggatgtca tcgcattttg taaagaacgc ctgtccgctt acaaaatacc 428761 tgaagttgaa tttgttaacg aactgccgaa aaacaacctt ggcaaggtga aaaaagacgt 428821 cctgcgcaat caggctgtac attcataaaa gaagaagccc gtccacttta tgtggcgggc 428881 ttctttgcag ttgcacagac ggaaagctca ggcttaatgt tcttaaattg tatatcaatg 428941 tcttcgaagc cggctgcttt aaagtcagca atcatctgtc ttccaaatga tttggttttc 429001 tcaggactgg catccgcttc ccgcggctgc atcgtaatgg ctgctttgcc gcctggcttt 429061 aatgcccgat aaatctgttt tatgcctttt gtttggtcat tccaaatggt gtagttgtta 429121 acggaaatca ctttatcata aaacgaggcg gggagaggaa atgtctcgat gcttccttgt 429181 atcaggcgta cgccctttgg tttcactctg cgggcggcca gcttcagcat ggcctctgat 429241 acatcaatcc catgaagatg aacatccttc tcgcgtttca gcatctgctg catgcagtat 429301 cccgggccaa acccgacttc taaaatgctg tccccgcgcg tgatacccag ctgattgatt 429361 gtccactgat tcagtgtttg attttcagca gccatgatgt acccggcaat catgccgatg 429421 acgccctttg gcctgctgaa tcttctagaa agcatgttaa tcattcagca accaaccccc 429481 tttttgagtt aatttcctct cagcgttcca tgtgaaacat ttttctgata aagcaatgcg 429541 aaggtgccaa gccatgttta tccaaagagt gtgtgaggta cacaacaaat agacatgaaa 429601 acaaaggagg agaatcatca tggcaaatta tccaaaagaa ctgccggcac aaactcaaag 429661 tcgccagccg ggaattgaaa gcgaaatgaa tccaagtccg gtgtatgagt acgaggatta 429721 taaaggagca gacaaattaa aaggaaaagt agctcttatt acaggcggcg acagcgggat 429781 cggacgcgcg gtttccgtcg cttacgcaaa ggaaggcgca gacatcgcca ttgtgtataa 429841 ggatgagcat gaagacgctg aggagacgaa gaaacgtgtt gaacaagaag gcgtaaaatg 429901 cctgctgatt gctggtgacg taggtgaaga ggaattctgc aatgaagcgg ttgaaaaaac 429961 ggtcaaggaa ctaggcggcc ttgacatcct tgtcaacaat gcaggtgaac agcacccgaa 430021 ggaaagcatc aaagatatta cgagcgaaca gcttcaccgc acattcaaaa caaattttta 430081 ttctcaattt tatttgacta aaaaagcaat tgattacctg aaaccgggca gcgccatcat 430141 caatacgaca tccatcaacc cgtacgtagg gaacccgaca ctgattgatt atacagcgac 430201 aaaaggggcg atcaatgcct ttacaagaac aatggcgcag gcgcttgtca aagacggcat 430261 ccgtgtaaat gcagtcgcgc cgggtccaat ttggacgcca ctaatcccag ctacgttccc 430321 tgaagaaaca gttgctcaat ttgggcaaga tacgccgatg ggccgtcctg gacagcctgt 430381 tgagcacgtc ggctgttatg tgcttctggc atcagatgag tcctcttaca tgacaggtca 430441 gaccctgcat gtcaacggcg gaaactttgt gacgacataa gagggagtga gacatatggg 430501 catcacgaaa gaagaagtga acagctacta tcaaaaagca gggattgtat taacggacga 430561 ggaagtagac caaatccagc tgatggatta cggcttagga aaagaaagaa aagtcgggct 430621 ccagctcttc gtctacgtca atacagaccg ttattgttca aaggaattgg tgctgtttcc 430681 gggacagact tgcccggaac accgccatcc accggtcgac ggccaggaag gcaagcagga 430741 gaccttccgc tgccgctacg gaaaagtgta tctttacgta gaaggagaaa aaacgccgct 430801 tccaaaagtt ctccctcctc aggaagacag agaacactat acggtctggc acgaaattga 430861 gctagaaccg ggcgggcaat acacgattcc accaaacaca aagcattggt tccaggccgg 430921 ggaagaaggt gccgtcgtga cggaaatgtc atcgacgagc acggataaac atgatatctt 430981 taccgatcca agaatataag gatgggctta acagcccatc ctttttgtat tgaaaaaaac 431041 agaatcatcg ctataatggg taaaaaagga aagagggcga ggcaatgttc acttgcaagg 431101 taaatgagca catcaccatc cgattattgg agccgaagga tgcggagcgg ctggccgaac 431161 tcattatcca aaatcagcag cggcttggca agtggctgtt ttttgcggaa aatccaagca 431221 gcgctgacac gtaccgagaa acaatcattc cagattggcg gcgccagtat gccgacctga 431281 acggcattga ggcgggtctc ctttatgacg gcagcctatg cggcatgatc agcctgcata 431341 accttgatca agtgaatcgt aaggcggaaa tcggatattg gattgccaaa gaatttgaag 431401 ggaaaggcat tattacagct gcctgccgaa aactcattac gtatgctttt gaagagcttg 431461 agctgaatcg tgtggcgatc tgtgcggctg tcggaaacga aaaaagcaga gcggttccgg 431521 agcggatcgg gtttctagag gaaggaaagg cacgggatgg cttatacgta aacggcatgc 431581 atcacgacct cgtctactac agtctgttaa agcgtgaatg ggaaggcgaa aaataaagag 431641 cacactttct tgtttaaatc ttccccggat gtggaaaagt aacagcggag acgttaaaaa 431701 ggagtgattc gagatgaatc agcaagacat taaacaaaaa gtgcttgatg ttctagatca 431761 ccataaagta ggttcgctcg caacagttca aaagggcaaa ccgcattccc gctacatgac 431821 ttttttccat gacgggctga cgatttacac accgacaagc aaggaaactc ataaagcgga 431881 agaaattgag aacaacccca atgtccacat tttattaggc tatgattgtg aaggttttgg 431941 cgacgcatat gtcgaagttg ccggaaaagc aaagatcaac aattcggcag aactcaagga 432001 caaaatatgg agttccaaat tagagcgctg gtttgacggc aaggatgatc cgaatctggt 432061 gattcttgaa attgaaccgg aggatatcag attaatgaat gccggggaga aaacaccggt 432121 ctcactcgaa ctataaaaaa tttgtgtttt caggggcgat atgttattat gaatagctag 432181 taagaaaaat aagcaaataa aaaagaaagt aaacttcttt tttctgtttt gagagagaag 432241 cttaccgctt cccaagcagc ataaccagct gcccttattc ttttccttca taacaaatcg 432301 cccctaacga tgagatggaa aaaagacttt tttgttttac aattcacacc ggcgcggctt 432361 cggagccgca gtgacgattg agaggtaggg ctttcgttgt cttgtgttca agaaatttcc 432421 atggtgttta ctttccagaa tgattcttcg gaacaatgct ttatgaatct aacccgcctg 432481 acttggcgga tgatataatc tttatttgcg tatagaaaag aataagacaa accgcccggc 432541 gtacgccgga cggttttttt attgcaaaaa acacatcgta ctgaaacctc cttgtcttct 432601 ttccagtctt atctctagga tgaaattgga ggaagaataa cgtgcatgtc attacaacac 432661 aagtactttt tattttttgt tttttattgc tgattcactc gatagaaacc ttagcctatg 432721 cgacaaggct ttccggagct cgcgttggat ttattgcgtc cgcgctttct ctgtttaatg 432781 tcatggtcat cgtatccaga atgtcgaata tggtgcagca gccctttact gggcatttaa 432841 ttgatgatgc tggaaaaaac gcactggcga ttgtagggga gcagttccgc tttttaattt 432901 tcggatcgac agtcggcacc attttgggca ttatcctgct cccgtctttt gtcgctcttt 432961 tttcacgggc gattattcac ttggcgggcg gcggcggctc cgtttttcaa gtattccgaa 433021 agggattctc gaaacaagga ttcaaaaatg ccctttccta tttgcgtctg ccgtccattt 433081 catatgtaaa aggatttcat atgcgcttga ttccgaagcg tttgtttgtc atcaacatgc 433141 tgatcacatc gatttatacg attggtgtgc tttcggcttt atacgcaggc cttttggcgc 433201 cggagcgcag cacgacagcc gtcatggctt cgggtttgat caacggaatt gcaacgatgc 433261 tgctggctat ttttgttgat cctaaggtat ccgttcttgc tgatgatgtg gcaaaaggaa 433321 aacgaagcta tatctattta aaatggacct ctgtcacaat ggtcacatca agggtggcgg 433381 gcacactcct cgcccagctc atgtttattc ccggggccta ctatatcgcg tggctgacaa 433441 agtggtttta ataagaaagg ctggatcata aagatccagc ctttttgcgc ttccttattt 433501 atagttcctt aatccgcggt cgtacaaaaa atttccgaat gggacgaaag cggcgatgaa 433561 gccggcagct gaccatttca gcggccattt gacagagaag gttgcataag ccaagacaag 433621 caaatacaaa atgaacaacc cgccgtgaac cgaaccgaca attgtcaccg caagcggaag 433681 gcctgcccaa tatttaagcg gcatagcgat gaacaacagg attaagagtg acattccttc 433741 aataaaaccc atcgtgcgaa gtcttccgat cggcgtgtgc agcataaatc gccctccttg 433801 tggacacgtt ttcattttat actataaaca atccgggggg gcatatgaca gctttcaaaa 433861 aatgttcgga aaacattcat ttttacatgc cttttctagg gaactgtact tgtcatttac 433921 aaaaataccc gagataatgt gtacaaaatc aaaaaagaag gatgttgaaa tgaaacttga 433981 ccagattgat ctgaatatca ttgaggagct gaagaaggac agccgtttgt cgatgaggga 434041 attaggcaga aaaattaagc tgtcgcctcc atctgtaaca gaacgggtaa gacagcttga 434101 atcgtttggc atcatcaagc aatacacgct ggaggtcgac cagaaaaaac tggggcttcc 434161 cgtttcctgc attgtggaag caaccgttaa aaacgcggat tatgagcggt tcaaaagcta 434221 tattcaaaca ttgccgaata ttgaattttg ctaccggatt gcgggtgcag cctgctatat 434281 gctgaaaatc aatgccgaaa gcctcgaagc ggtagaagat ttcattaaca aaacatcgcc 434341 ctacgcgcaa accgtcactc acgtcatttt ctcagaaatt gacacgaaaa acgggcgcgg 434401 ttagagagtg ccgcgcgaag tctgttataa taacaggatg agcgtgaaag aaagagaagt 434461 gatcaagcat gtcaaaaaca gttgtattag ctgaaaaacc ttcagtcggc cgggatttag 434521 cccgggtact gaagtgccat aaaaaaggaa acggttatct cgaaggcgat caatatattg 434581 tgacttgggc tttaggccat ttggtgacgc ttgctgatcc ggaaggctac ggaaaagaat 434641 ttcaatcatg gcgcctagag gatctgccga ttatcccaga acccttgaag cttgtggtga 434701 taaaaaaaac cggaaagcag ttcaatgcag tcaaatccca gcttacccgt aaagacgtca 434761 atcagattgt catcgcgact gacgcaggcc gggaaggtga gcttgttgcg cgctggatca 434821 ttgagaaagc gaatgtccga aaaccaatca agcggctgtg gatttcatct gtgacggata 434881 aagcgatcaa ggaaggtttt caaaagctgc gcagcggcaa agaatatgaa aacctgtacc 434941 attctgccgt cgccagagcg gaagcggatt ggattgtggg gatcaacgcc acccgtgcac 435001 ttaccacaaa attcaatgcc cagctctcat gcgggcgtgt gcagactccg acgcttgcca 435061 tgattgcaaa gcgcgaggca gacattcagg cgtttacgcc cgttccgtat tacggcatac 435121 gtgctgcagt cgacggcatg acgctgacgt ggcaggataa gaaatcaaag cagacgagaa 435181 cgttcaatca agatgtaaca agccgtttgc taaaaaatct ccaaggaaag caagcggtcg 435241 tagctgagct gaaaaaaaca gcgaaaaaaa gctttgcgcc tgcgctttat gatttaacgg 435301 agctccagcg tgacgcccac aagcgcttcg gtttttctgc caaagaaacg ctttctgtcc 435361 tgcagaagct atatgagcag cataagctcg tcacatatcc gcggacggac tctagatttt 435421 tatccagtga catcgtcccg acgttaaaag accgtctgga aggcatggaa gtaaaaccgt 435481 atgcccaata tgtcagccaa attaaaaaac gcggcattaa atctcataaa ggatatgtca 435541 atgacgcgaa ggtgtcagac caccacgcga ttatcccgac cgaagagccg ctcgttctca 435601 gcagtctgag tgataaagaa cgaaagctgt atgacctgat tgcgaaacgt ttcctggctg 435661 tattaatgcc tgcattcgaa tatgaggaaa caaaggtcat cgcagaaatc ggcggagaaa 435721 cctttacggc gaaaggcaaa accgtgcagt cgcaagggtg gaaagccgtt tatgatatgg 435781 cggaagagga tgatgagcag gaggatgaca gagatcagac acttcctgcg cttcaaaaag 435841 gcgacacact tgccgtccgc acgttaacgg aaacaagcgg ccaaacgaag ccgcctgccc 435901 gctttaatga agggaccttg ctgtcagcga tggaaaaccc aagcgcgttt atgcagggag 435961 aagaaaaagg cctcgtcaaa acgcttggag aaacaggcgg cctcggcacg gtggcaacgc 436021 gtgccgacat tattgaaaaa ctgttcaaca gctttttaat cgagaaaaaa ggccaagata 436081 tttttatcac atctaaagga aaacagctcc tgcagcttgt tccggaggat ctgaaatcac 436141 cggccttaac agcagaatgg gagcaaaagc tgtctgcgat cgcggccggc aaattgaaat 436201 cggctgtttt tattaaagat atgaaggctt acgctcacca aacggtaaaa gaaatcaaaa 436261 acagcagcca aaccttccga catgacaaca ttacgggaac ggcatgtccg gaatgcggca 436321 aaatgatgct gaaagtaaac ggcaaacgcg ggacgatgct cgtgtgccaa gatcgtgaat 436381 gcggaagcag aaaaacgatt gcccgaaaaa caaacgcacg ctgcccaaat tgccataaaa 436441 gaatggagct tcgcggccaa ggcgagggcc aaacctttgc gtgtgtgtgc ggtcaccgtg 436501 aaaagctctc tgtatttgaa aaacgaaaaa acaaagacaa agcgcgtgct accaaacggg 436561 acgtatcctc ttatatgaaa aaacaaaata aagatgagcc gattaacaac gcgctggcag 436621 aacagctgaa aaaactcggt ttggataaat aataaaaaaa cctgtgccta tcgcacaggt 436681 tttttattgg acttaggtcc tgttttctta atgttcaaaa agggaaaaaa aagctagcaa 436741 tctgcatttt ttttctttta tagtaaatgt actttgtaac atggcagtca tattttcgtc 436801 tataactatt tgtgagcgtc tgatttgctt caggcgacaa agggggattt gcctgtgagg 436861 catgtactaa ttgctgtcat cttattcttc ttatctatcg gactttccgc agggtgtgct 436921 gaagctggaa acaagaccca aaatcagtcg gcgacagaag tgaatgccag cccgctccag 436981 ccggcggaat atttcatcta tcacaattta atgaatgaca aagggctgat caaaaccgat 437041 ttttcagacc agccttctta cttgtcggaa tctctcggac tgtggatgga gtttctgctc 437101 agcaaaaatg acgcaccaca tttccaggat caatatcagc atctgactga ttcatttctg 437161 atgagcaatc acttggtgac gtggaagatt caaaatggcc aagcgagcgg gacgaatgcg 437221 ctgatagatg atatgagaat tatgctgtct cttgaccaag ccgccgcaaa atggggccgc 437281 agcgactacg cgcaaacggc tagggatatc ggcacgtctt tgaagacata caatatgaac 437341 aacgggtttt ttacagactt ttacgactca caggccgctt caaaggatgt gacgctttca 437401 tacgtcatgc ctgatgcctt agctgtctta aagaagaatg gaatcataga cgaagaaaca 437461 gaacagcgga atgccaatgt tctctattca gctcctttaa aaaatggctt tctgccgaag 437521 acatacagct cggagacgaa ggaatacaca tatgatagtg aaatcaacct gattgatcag 437581 ctttacgctg cttggcattt gccggaaggg gatgaaaaag catctgtttt agcggactgg 437641 atcaagcagg aatttcagaa aaacggaaag ctgtacgggc ggtattcggc atatacgaag 437701 gagcctgccg tccaatatga gtctccatcc gtatatgcct tagccgtatt gtttttgaca 437761 aaacagcatg aaaacagttc tgtcatcaaa gccatatatg atagaatgaa tgactttgaa 437821 attcatgatc cggtgaaatc gtattatgga ggctatatga gcggcactca gacgcattca 437881 tttgacaatc tgctgccgct gttagccgaa aggaagcttt ttaatgaaaa tatcattcag 437941 tgaatcacaa aaattatttg cttatttttc agggctcatc gcggccctgt ctttgtttat 438001 ttattatgtg tcagcccagc aatcagaagg tgctctgatc ctttgcatca catttggcgt 438061 catcgccgca ggcatctggt tcggcccgat ttacgcgctg gcagtgacct taatcgtact 438121 ctttgttctc ggcaccttaa tgatgttttt ccagactgga cagacatcgc tctttccggc 438181 tgaggaaggg ctgcgaatgc ttgtcgtgtg gggaatcgcg cttttgctgt tttcttttat 438241 ttctggaaga atccacgata ttacagcaga gcttcggcgc tcaatgacac ggcttcaatc 438301 cgaaattaaa agctatgttg ctgttgacag agtgactggt tttgataaca agcaaaggat 438361 gaagctggaa ctttcagaag aaatcaagcg ggcggagcgc tacggcaatt cttttgtgtt 438421 tttgctgctc catatgcatt atttcaaaga gtttaagtct ttgtacggtg aaaaagaaac 438481 ggaccgcctc ttccaatatg tcggtcagca aatcaggaca agcgttcggg aaacggataa 438541 gaaattccgt ccctctgacg agcgtatcgg gatcgtgctg acgcacacgc ctgctgaaca 438601 tatgccggcc gttctgacta agctgaagaa acaattggat acatatcagc tggaaaatgg 438661 aaagtatgtg tcgcttacgt tccacgtttg ctatttgccc taccgcaacg atatccaaac 438721 agctgatcaa tttttagaag aactggaaaa cgagatgatg atgaatgaac tataaaggaa 438781 tcacattgct atgcgtcatg atgcttctat tttcagctat tgcgtctttt cccgtttctg 438841 cgcaagcgaa agatcaggat gccggcattc tcatcatcta ctcaaccttg gacggcaaag 438901 agtcgtcaca agtcaaaatg ctcgatttgc ttgcgggcca ctttacatcc catgtgacag 438961 tcaaaaaaga ttcagacgtt gaagcgtcgg atttcaaagg gaaagaccat gtgatttatt 439021 acggccaaac gaaaagaaag ctcagccaaa aattgctgtc tcttatcagc ggcgtgaaaa 439081 aaccggttgt cgccattggc tataacgcag gccaaatcag ccaattttct gggctttcat 439141 tagcccgcaa agaaaatgtg tttcaggttc acagcaggtc agaaaaggcc gatgtgtctc 439201 tggaaagcgg gcttaacgtg ctgagtgtat caggcctgaa aggaacggcg ctttacacct 439261 tcaaagcgga tgaaggcaca acgcattctt ttatatggaa aacaaaaaaa gggaatgtgt 439321 acattggatt aacaaatttg ttaaatgaca atttgatcgt ggcgaaacag ctcagagaag 439381 ctttcggaga gaaggcgggg acgacgttat tgtatttgcg tctcgaggat atcagcccga 439441 tgtctgatga aaaactgctg cttcaagccg gtacatacct gcataagcgg catattcctt 439501 ttatcctggc ggtcattccg gtttacttga atccggaaac aggcgacaaa gtgtatttgt 439561 ctaatcaacc gaagatggtc aaggtgctga agaagctgca aagcatgggc ggcagtatca 439621 tagttcacgg ctatactcac gcttatcgct acagtgaaac aggagaggga tttgaatttt 439681 gggatgcaaa ggcggatcag ccgattacat ccggaaatgc cgaagacccc ccgtccattt 439741 tggagaaaga acaggacttc ccgaacgaac aagcctatca cagctatctt gaaccatttc 439801 gggaaaagga agaaacgtat acaaaacaaa aactgacgcg tgccattgag gatttgacat 439861 catcgggtct ttacccgctg gcgtttgaag cgccgcatta cacgatgtcc gaatatggct 439921 atcaaatcgc ctcgcagtat tttacaagca ttttcggcca ggtccagctc agcagcacaa 439981 catggaaaac atccggtgca cctccgtttg tgactgctcc ttcgatgctg cacggaatga 440041 cgctttatcc ggaaacgatc ggctttgtcg acacatcgaa gcaaaacccg ctcggtgaga 440101 tggaggagca tatctcccag atgattgatt ttgaaggcgg agtagccgga ggattttatc 440161 acccgtacct tgggatgaaa tatctgcctg agctggttga tcagatggaa cgcattccag 440221 acagtgaatg gcttgattta aagaaaacga aacaaaccgt caaaacagac aaagtggaaa 440281 ttcatacaag cggtgacgga acgattcagg tgaaaaacgg cgtaagcccc atttacgagt 440341 ttttcgatca tcaccggcaa acccctctgg aaaaggcgtt atggattctc tccgctgttg 440401 tgctcttatt tgtcatcatg tttgtcagtt atacgtttta cttgagagcc acattgaaaa 440461 aacgaatttt taaggagaga agaagccttg ggtaatacgc tgttctttat ctcgctaagt 440521 ttaatatggg ttatgcttct ctaccacatg ttcctcatgc agggcgggtt tcgccactat 440581 atgaccttcg aacggaatat cccgaagtgg agagaaaata tgaaggaact gccgaaggtc 440641 agcgtcctca tcccggcgca taacgaagag gttgtgattc ggcagacgct gaaggccatg 440701 gtcaaccttt attatccgaa ggaccggctg gagattatcg tcgttaatga taattcatca 440761 gaccggacgg gtgatatcgt caatgaattt tccgagaaat acgatttcat caaaatggtg 440821 attacgaagc cgccaaatgc aggaaaagga aaatcctctg cacttaactc gggttttgcc 440881 gaatcgaacg gcgatgtgat ctgtgtgtat gacgccgaca acacgcctga gaaaatggcc 440941 gtgtattacc tcgtgctcgg cctgatgaat gacgaaaagg caggcgccgt ggtagggaaa 441001 ttccgcgtca tcaatgcggc aaagacgctg ctgacgaggt ttattaatat cgaaacgatc 441061 tgttttcagt ggatggccca gggaggcaga tggaagtggt tcaaaatcgc cacgatccca 441121 ggcaccaact tcgcgatccg cagaagcatt atcgaaaagc tcggaggctg ggatgacaaa 441181 gcgctcgctg aggatactga gctgaccatc cgggtatata atctcggcta tcacatccgc 441241 tttttccctg ccgccatcac gtgggagcag gaaccggaaa catggaaggt atggtggcgc 441301 cagcgcaccc gatgggcgcg cggcaatcaa tatgtcgtgc tcaaattttt ggcgcagttt 441361 tttaagctga aacgaaaacg gattatcttt gatttgtttt attttttctt tacgtacttc 441421 ctgtttttct ttggcgtgat catgtcaaat gcgatttttg tagtgaattt gttttatgat 441481 ttgcatttgt ctgttggatt tttggcaatg attctctgga ttttggcgtt tttcttattt 441541 atgacagagg tcatgattac gttgagcatt gaaaaaacag aaatgaacaa gcaaaacttt 441601 tttatcgtat ttctcatgta cttcacatac tcgcaggcat ggattgtgct tgttatctac 441661 tctttattcg tagaaatcaa gcaccgttta ttcaagcaag aggtcaaatg gtacaagaca 441721 gaacgataca atcaacataa aagcgggtga cctttttgaa acaaataatg atttttctca 441781 caagcttcat gctgctggcg atgactggac aaacggctct tgccaaagac gtacaggtca 441841 gcggttcgct ccttgggaaa agcagccaag aacaagccaa acagcaggtg ctgacaagcg 441901 agctgattac actgtatgga tcaaaagaca gcgcagagct gacgtatcag atcccggcag 441961 gcgcctcttc gggcaatcag caattggtaa tcgaatacga ggcatcaaat cttttaattt 442021 ctccatcatc gttaacggtt gtcattgatg atgaaccggt caagacgtta aagcttgatg 442081 gtgattccaa acggaaaaca gtgaagctga atctgaataa aagccagtct gcgcaaggct 442141 atcacaacgt atcgctgaaa ttctacggcg taatgaaaga gggcgtgtgc gtcagacagg 442201 atacatcagg caactggatc aaaatttatc cggacagccg gctgacactt gctgacagca 442261 gtgaagcgaa gggaacgtcg ctggaccatt atccgtatcc tttcgcccaa tctggaaata 442321 cagcggaaga aacagctatc gtcattccgg ataacccaag ttcagcagaa atagaagctg 442381 ctgttaaaac agaaggctat ttgaaaacgg tggacagcag tgtcagtatt gcgtatgtca 442441 cggaatctga actgaaaaaa atcgataagc cgacgattgt tatcggcgtg gacaagcatt 442501 ggaacggcaa agtgaaaaaa ctgttgaaac aagccgggct acaggcaaaa ggagaaaacc 442561 ttctgcttgc ggagcgggtg ctgaaagcag agggcaaaca gcagccggtt ctgtttgcgc 442621 aagcggcgtc cgaggacgcg ctcacaaaaa aaatcagcgt gatgacagat cagacatata 442681 caggccagct cagcggcgat acactttcaa tcagcaagct tcagcagact gaaaaaaaag 442741 aaagcgataa gctgaccctt gagaattttg gagcgggtga tatcacaatt ggagccgaca 442801 aaacatcttc agcacattat ttttatccgg cttcggctgt tttagatgaa aaccaatcgg 442861 cgaagctgtc gcttaaactg aaaaagtctg aaacgattca agcctcaacg gctgaaaacg 442921 agtcagcctc tcaggctgca gaactgaaag tgatgatcaa cggccagccg cactcggtcc 442981 ggcttgatga attaggaaaa gaagataaaa acggattcta tcatgtcaca gtgaaagtgg 443041 accctaagct gctgcaaaaa aaccgctaca ttgatattca gttcgtcacg accggtttaa 443101 aggaaaacaa cccttgtaac accactgatg aagaaaagtg ggtttttatc gataaaaaca 443161 gtacattatc atacgccatc aaaggcatgt ccccgtcagc ggattttcaa gagtggccgc 443221 tgccttacgc cggaaaccag gatcaaacaa cgttaatcgt gcttcctgac accgtaagcc 443281 aatcgaagct agaggagctt tctctcgtaa cagaatcctt tggcaacgaa gcacagcatt 443341 catatacggt aaagaaatca tctgacgtta cagcaaatga tgcgaaagga cgaaacctca 443401 ttttcatagg agggatcaat caattttctc ttctgaagga gaaatcatca gatctgcttg 443461 tgccgcagga aaagaacggc tcgtttgatg tatctagttt cgagatgctg aatgagacga 443521 caaaacaagt ggtatttacc caagcatcgg tttgggattc acgctataca atggctgtct 443581 ttgcaccgtc aaaaggagat ggcacggctg tcacaaaaga gatcatcagt tatctgaaca 443641 gcaacgatga gtcggcaacc gtccttaatg aaacaaacag ccagcaggtg tttacaaacc 443701 accagcagct caaatcggaa acaaacagtt ccgatgcaga acaaccaaca caggatcata 443761 gccagaaatg gatgtatatt ggtgtgctgg cactcattat ggtggttgcg gcagtgttca 443821 tttggattgc cgtaagacgc aaaaaaagaa agacagatac agaataaaac agaggcgatt 443881 ttagcctctg tttttttatt tttggtaagt aaattccatt tgtggaacct gtcattttat 443941 ttttttctct cagccaataa gcctctttac aacgtgcggg aacgggagta tgatctcttt 444001 tagaaaacaa atcgcttaat ctgaaatcag agcgggggac ccaatagaac ggctttttgc 444061 cgttggggtg aatccttttt aggtagggct aactctcata tgcccgaatc cgtcagctaa 444121 cctcgtaagc gttcgtgaga ggagatgaat gaaacctgtg ttcgatgtta tggcacaggg 444181 gcatccgttt gcctctgtgt tttttgttgt tcatttttga atgcaaatcg catacagaga 444241 catcatagca gaaaggacta tcatcaacat gtgagagcaa gacactgatg gatgttttat 444301 tgttttaatt gaaaaatgag aaattaaaag gggaagacat cgatgtatca ttcaatcaaa 444361 cgttttttga ttgggaaacc actaaaatcc caagcagctg gagagcaaaa actgacgaaa 444421 ttaaaagcct tggctatgct ttcctcagat gcgctgtcat ctgtcgcata tgggacagaa 444481 caaattctaa tcattttggc aacaatcagt gcagccgcat tttggtactc cattccgatt 444541 gcggttggcg ttctcatctt gctgctcgca ctgattcttt catacaggca aattatttac 444601 gcttatccgc agggcggcgg ggcgtatatc gtttctaaag aaaatctcgg tgaaaaaccg 444661 ggattgattg cgggcggttc attgcttgtt gattatattt taacagtagc ggtaagtatt 444721 tccgcaggca cggatgccat cacgtcagcc tttcctgcat tgcatgatta tcatgtgccg 444781 atcgctattt ttctcgtgtt agtgattatg attttgaacc tgcgcgggct ttcggaatca 444841 gcatccatac ttgcctaccc ggtttatctg tttgtggtgg cgcttttggt tctcattgca 444901 gtcgggttgt ttaaacttat gacaggacaa atagaccagc cagcccatca tacatcgctc 444961 ggcacacctg tagccggcat tacgctattt ttgctgctta aggctttttc ctccggatgc 445021 tcagcgttga ccggggttga ggccatttct aatgcgattc ctgcattcaa aaacccgcct 445081 gcgcgaaacg cggcaagaac gcttgcgatg atggggattt tgctggcgat tctgttttcc 445141 ggcatcacgg ttctcgcgta cgggtatggt acggcgccga aacctgatga aacagtggtt 445201 tcacaaattg cgtccgaaac ctttgggcgg aatgtgttct actatgtcat ccaaggtgtc 445261 acatcgctta ttttggttct tgcggcaaat acgggattct cagccttccc gcagcttgcc 445321 ttcaacctgg cgagagacca gtatatgccg cgaatgttta cagtcagggg cgaccgctta 445381 ggcttctcaa atgggattat ctttttaggc tttgcctcca ttgttctcat tatcttattc 445441 gggggacaga cggagcactt aatcccgtta tatgctgtgg gcgtatttat tccatttacg 445501 ctttcacaaa ccggcatgtg catgaaatgg atcaagcaaa aaccaaaagg ctggatcgga 445561 aaaatgctga tcaactcctg cggcgctctg atatcattta tggttctatc cattctgttt 445621 gtgacgaagt ttaatgtcgt atggcctgtg ttaatcttta tgcctatcgt cgttttgctg 445681 ttttttgcga ttaaaaatca ctatactgcg gttggtgaac agcttcgcat cgtagacaaa 445741 gagccggaag aaatcaaagg caccgttgtg attgtgcctg tggccggtgt caccaccgtc 445801 gtgcaaaaat cgattcacta tgcgaaatca ctgtccgatc aggtgatcgc cgttcacgtg 445861 tcatttgaca gagaacagga aaagaaattc gaaaaacgtt gggaagagct taataacgga 445921 gtgcgtctcg tgacgcttca ctcctcttac agaagccttg tccatccgtt tgataagttt 445981 ttggaaacag ttgaggcaaa agcgaagaag gagcagtttt ccgttatggt gctgtttccg 446041 caatttataa cgaaaaaacg ctggcacacc atccttcaca accaatcggc cttcctcctc 446101 agagtccggc tgttctggaa aaaggacata atggttgcca cactgccgta tcattttaaa 446161 aagtaaagct ctaggaccaa gggaatcacc ttggtccttt ttagcgggaa aaggaggtat 446221 gggggtgtat acacaaggtg cttttgtgat cgtattgaac gaaagtcagc aaattctgct 446281 ggtgaaacga aaagatgtcc ctctatggga tttgccgggc ggcagggttg atcccgggga 446341 atcggctgag gaagcggcag tgcgggagat attggaagaa acgggataca atgcagcgct 446401 ttctgcgaaa ataggtgttt accaaaggcc aaagtttcaa gatgaacagc atctgttttt 446461 cggaagcatt acaggcggac aagcaatggc tgacggcaca gagacagcgg gattaaagtg 446521 ggtttccccg gggcgtttgc cgctttttat ggtgccgaat cgaaaaaggc agatcaatga 446581 tttcaagaac ggcgctcaag atgtaaatgt caccgtcaag gatagcgggt tgctcgcggc 446641 gatcgacctg ttgaaaagaa gactgggcaa gtgattcagg tctccgggtt ttaaagcctt 446701 tctcctgtgg tattgaaaaa aggaaaaagg aggatacgtt atggcacaca aaactgcagg 446761 acaagcaatg acagagctgc ttgagcaatg gggagttgat catgtatacg gcatccccgg 446821 agacagtata aatgagttta tcgaagaatt aagacacgaa agaaatcaac tgaagttcat 446881 tcaaacccgc cacgaagagg tagcggcact ggcagccgcg gctgaagcaa aactcaccgg 446941 caagatcgga gtctgtctgt caatcgcagg gccgggagcg gtgcacttat taaatggttt 447001 atatgatgct aaagccgacg gcgcccctgt gctggcgatt gcaggacagg tttcttctgg 447061 cgaagtcgga cgggactatt tccaggagat taagctggag caaatgtttg aggacgtggc 447121 cgtgttcaac agagaggtac atagcgcgga atcacttccg gatctcttaa atcaggcgat 447181 caggaccgcc tacagcaaaa aaggcgttgc ggtattgagc gtgtcagatg atttgtttgc 447241 ggagaaaatc aaacgggagc ccgtgtatac ttcaccggtg tatattgaag ggaacctaga 447301 accgaaaaaa gaacagctcg tcacctgcgc ccaatatatt aataacgcta agaaaccgat 447361 tatcctggca gggcagggaa tgaaaaaggc gaaacgggag ctcttagaat ttgcggacaa 447421 agccgccgct ccgatcgttg ttacactccc ggcaaagggt gttgttcccg ataagcaccc 447481 acattttctc ggcaacctcg gtcagatcgg aacaaagccg gcttacgagg caatggagga 447541 atgtgattta ttaatcatgc tcggaacgtc attcccgtac cgtgattatt tgcctgatga 447601 cacgccggcg atacagctcg attcagaccc ggcaaaaatc ggaaaacggt atccggtgac 447661 agcgggcctt gtctgtgatt cggctctcgg tttgcgcgaa ttgacagagt atattgaacg 447721 caaggaagac agaagattcc tgaatgcctg cacagaacat atgcagcatt ggtggaacga 447781 aattgaaaaa gatgagacag aggcaacaac accgcttaaa cctcagcagg tcgtggcccg 447841 tcttcaggaa gcggcagccg atgatgcggt gctctctgta gatgtcggca ctgtgacagt 447901 ctggatggcg cgtcatttca aaatgaacgc gaatcaggat ttcatcgttt ccagctggct 447961 tgcgacaatg ggctgcggcc tgccgggagc gattgcagcg agcttgtccg aaccggaacg 448021 ccaggcgatc gccgtctgcg gtgacggggg attttccatg gtcatgcagg accttccgac 448081 cgccgttaaa tataagctcc cgatcacagt cgttatttta aacaacgaaa atctcggcat 448141 gattgagtac gagcagcagg tcaaaggcaa tatcgactat gtcacaaaac ttcaaaatgt 448201 cgactatgcc gcatttgcag aaagctgcgg agcaaagggc atcaaagtga ccaaagcgga 448261 agagcttgcg ccggcttttc atgaggcgct gcactctgac caaccggtcg tagtggatgt 448321 catgattgga aacgaaccgc cgcttcctgg caaaatcacc tacgggcagg cgaaaggctt 448381 tagcaagtac atgctgaaaa acttcttcga aaaccaaaaa tttgaaatgc cgtcactgaa 448441 gaaaagtttg aaacggttat tttaaaaaaa caggggccct aagagccctt gttttttttt 448501 ttttttttgg aaacaaatgt attttcagca tgtttgaatt cataaaatga tcggtatatg 448561 tattaggaac tgatttcgcc atactcgaaa cagacaaaag gacaaatgca tcttgtttca 448621 aaggaagatg catttgtcct tgcatgctta ttcttatcaa atcttacaga actcttctca 448681 taataggtta tttttctttt ttcttcagcc cgaagaagaa aggaaaagca gaaccgacca 448741 agaaggtgcc gaataaaaac atgccgccga taaacacgtg gaaatttgtg tgtccggccg 448801 taaacgccgt gattagggaa atgatactga gcacgatcat ggcaatgccg ggcgcgactc 448861 tcatttttcc cttggattta tgggcagcaa cagaacataa aatgccgata acaataggaa 448921 caatccacaa ataaaacaga ataaatactg acatcatcaa aactccgatt tttcttctat 448981 cataacaaat ttctgtcaaa aagggtatca atgagctttt gcggaaaaat aaaaaccggc 449041 tttagaagcc ggttttttta tcgaaacgta tctacaatta aaaacacatt caaagcaacg 449101 atcaatacag caatcagcca agacaccact gtgatccatt tggcgttgat cagagatccc 449161 atgatccgtt tattgcttgt aaacataata agcggaatga gggcaaaggc gatcccgaag 449221 gacagcacga cctggctcag tacgagagcg gtcgtcggat taacacctga cgcgatgatc 449281 aagatcggcg gaatgatcgt gataaaacgc cgtacataca gcggaatgcg gtagttgata 449341 aatccttgca taatcacgtc gcctgaaagt gtgccgacag acgaactgga tagaccggca 449401 acgagcagcc cgatcccgaa caaagccgca gacatagggc tgacaagatg tccgaattgc 449461 tgaaatgcga cgtcgagatc ctcaacaaac aggccgtttt tgaagaataa tgcggcagcc 449521 acaatcagca tacttgcatt aatagcccct gcaatcagca tcgctattaa aatatcaata 449581 aattcaaacc taaagatttt tttccgttct gcatcagttt tgccaaccac ccgccgctgt 449641 gtaagggcag agtgtaaata aatggcgtgc ggcataacag ttgcgccaag aatacccgct 449701 gcaagaagca cactgtcggt gccatgaaac gccgggacaa aaaggccctt catcactgac 449761 acggcatcag gctttgcgaa aaaggtctgc aacgcaaagg cgatcacgac cacaaacagc 449821 ataccggcaa tacctgcttc aagtgagcga taaccacggc gctgaagctc caatatcgcg 449881 aaagaaccga tcgccgcaat aatagacgct tcaagcatcg gaatgccgaa cagcaaatac 449941 agtcccagag ccgctccgat aaattccgcc agatcagttg cgataatgac caactcgccc 450001 tgaatccata atccgatcga gacaggcttc gggaattctt cacgggcaac ctcaggcaga 450061 tttttgcctg tcgcaatacc gagtttggcg gatagggatt gaattaaaag cgccatgata 450121 ttggaaaata agatcaccca taagagcata tatccgtatt tagaacccgc cgaaatattc 450181 gttgcgaagt tgccgggatc aatataggca atggctgcta taaatgcagg gccgagaaaa 450241 gggagcagcc ctctgaatcc tctgattttc ccgtcaagcg catcttggac ggctttggaa 450301 cggggagatt gtgctgtgat gtccttgttc atcatgtctc acctgaattc tgtttgtttt 450361 tgccgtacaa caaagagttt ccttaaggca aattatttta tctacatcat atgaccatcc 450421 cggtttcttg tcaaccgaaa atgttcaaaa tacacttctg aatttttccc tgttatgtaa 450481 catgatatgt agggattcgt gataaggtcc catataaaaa gacatcgttt catttcgaaa 450541 cgatgcctcc tgtatctaat gagtctaggc ttccttccgc agcccgcgga atataaggcc 450601 cagcaagaac acgaagatgg ctgccccgat gatggccggg aaaatagcaa agccggcgag 450661 gctcggtccc catgtgccaa gaagtccgtg cccaatccaa gcgccgatca gcccggcaat 450721 catagagccg aaaattcctc ccggcagccg gtttcctaca atggcgctcc caattaatcc 450781 gataacaatt gcaacaacta atgaaaccaa aaagctaagc atcatgatca cctctcataa 450841 atgatttacc aatcaataac cgctcctgat catttcgaaa cacttgaaag catattcctt 450901 tatgatcctg ttttaatctt tctctgcaca ctgccgtcag ctaaatgaac aatgacctca 450961 gtgcctttat gcgccgcgat ttcctttgcc cgttcaatcg cttctttctt tgtatccttg 451021 atttcagaca cacgtttggc gccctcggct ttgactgccc agcctttttt atgcttaata 451081 acatgctctg ctttattcat gagctcgggg ccgctgccgc tgcttggatc agcatcgcgt 451141 tctgtctcat catcatgcgt caggaaatca tcaatttcat ctgtagaggc gttttccgcc 451201 cattccttcg ctttgcttgt cgcaattgga atcgcgcgcc cttcctcata gccttcatca 451261 atcatcgcat tcgcaatgtc tatcgccttt tttctcaccg gcttctcaag attttttaat 451321 gaagcaggat aatccttcat cgaccaaggc atgtctatca ctccttttcc ttttataaaa 451381 atggtacccg caggtgaaaa ataaaaacgc atccgaaaaa atgaaggtat actatatagt 451441 agaaaaaacg gaagggaagt gcgggttggg tgccaacaga acgaaaagaa gacttacatc 451501 agcaattaaa agagatagag aaatgggaaa aagatcagca aaaagtctgg ttttgggaaa 451561 agctcagccg tctcccgttt caactcctgg acaagctgac accagaattc atccagaaaa 451621 agatcggcaa gctcttggat gaggtcggca gctttgttca aacaggcgga cagtacctga 451681 catctgaaaa acagattatc aggatgtttc aaaagaaact gccggaggag atctttgaat 451741 cgctggagga catccggaaa gcgcctcttc ctgtcatgga tgaaattgcg gaaggaatgg 451801 gcaaaaacag aaccaacgca gcaaccgttc aaggcgcgac aaccggtgtg ggcggcgtgt 451861 ttacgctggc ggcagacatt ccggcagtgc ttggcttatc actaaaaaca ttacaggata 451921 tcgcagtcgc atacggctat gacccaaagg agaaaaaaga acgagtcttc attgtgaaat 451981 gcctgcagct tacgtcggct gatgttgtcg gcaaaagatc gattttgcag gaattaaaac 452041 actacgatca agaccgtaca tataagaatg tcgcttctca aatccaaggc tggcgagaag 452101 tcgttttggg ctatcgagac acgtttggct ggaaaaaact tttccagata gtgccggttg 452161 ccggaatggt ttttggcgcc gctgccaatc gctcaacatt aaacgacatt accgagacag 452221 gcatgatgct gtacaaaaag aggcgcattc ttgaacgact gaaagaaaca gaacgagaga 452281 tggaatagca gaaagcagac ggacaccgcg atccgcctgc tttttttagt ggaaacatac 452341 ccaatgtgtt ttgtttgttt aaaagaattg tgagcgggaa tacaacaacc aacaccaatt 452401 aaaggaggaa ttcaaaatgg cagacaataa caaaatgagc agagaagaag caggtagaaa 452461 aggcggagaa acaacaagca agaaccatga caaagaattc tatcaagaga ttggtcaaaa 452521 aggcggagaa gccactagca aaaaccatga caaagaattc tatcaggaaa tcggcgaaaa 452581 aggcggagaa gccactagca agaaccatga caaagagttc tatcaagaaa tcggtgaaaa 452641 aggcggagaa gccactagcg aaaatcatga caaagaattc tatcaagaaa tcggccgaaa 452701 aggcggagag gcaacaagca aaaatcatga taaagaattc taccaagaaa ttggctcaaa 452761 aggcggaaac gcccgcaaca acgactaatc aaaagcataa aggcagacaa cctgtaaata 452821 aaaaagcgat ccggcacatc agctggatcg cttttttttg gaatcttctc aatttatgcc 452881 gctattgaga tacaataagt gaaaaagggg ttttcgctaa tgtccaagat gcaaaacttg 452941 ctcgccatcg caaatgaagt caaagaaaag cacgccaatt tttcaatctc agaggtcaac 453001 gaccactgcg tgcgccttgc ggtgtttacg ggagaatatg actggcacca tcaccctgac 453061 tcagacgaat tgtttattgt tcttgaaggg gagctgctga tcgattttaa ggacaaagaa 453121 accgcggtgc tcaaagcaaa tgacagcctg ctgatcccta aaggcacggt tcaccgcaca 453181 cgctcttacg tcagaacggt aaatctctgt gtggagcata aacaagccga aaccgtcatc 453241 atagaggagc agccatgcta atcaaaaaga tgatatgtga agtagatgct gcaaacgctg 453301 aagcatttgc aaaagcgcag tcacagtggg aagcgttatc gcatataagc ggctttatca 453361 aacaggccgg cggctggcga aaaacgatag acgagccgct caccgcagaa atcatcagtg 453421 tatgggaaaa cagagaagcc tatgatcatt ttatggagaa cgaacatgac agcatatacg 453481 aggaaaacga tcagaaggct gtaattcttt cgatagaggt gacggtgtac gaagaggata 453541 aaccgttcgt tcacgatctg ttacataacc ccgatatccg gtacgaacca aactggacgg 453601 ttctgaaggc ataatcaaag cccaaaacat catgttttgg gcttgtctct ttactcgcgt 453661 cccggaagtg tattatgaac aaaaggcggt gctggtttta actccggttt ttctccaaac 453721 gtttttgctt ctttcacata ttcaaaggct tctccgtccg gcgctttttc attcagccag 453781 ttttgctcgg cgcttacttc gccttcagag aaattgataa gctgatgtga gaactcttgt 453841 ttttcgagcg ctttcgggaa tgtacccggc acaaccggac cttcctgtgc ttctaattct 453901 ttaatggcgg cgagccattg gttctggtgc atcgtgtcac gcgccagcag gaagctgagc 453961 atatctttga cgcctttgtc atccgtcatt tcaaacaggc gtgcgacctg cagacggccc 454021 tgagattccg cattcaggtt ggcgcggaag tctgccagca ggtttccgct tgctacgata 454081 taaccgccgc tccaaggtac gcctgtactg ctttccggca tggcgccaag tcctgataca 454141 atcgcatggt gagggttcat gccgcctagg atggagccga tgaccggatc ttcagcagct 454201 ttttcctgct gatcaagagg ggcatcctca agaagtctgg caatcatcgt tgcgatcatt 454261 tcaacatgcc cgagctcctc agttgccgta tccatcagca agtccttgta tttttcattt 454321 cctcttgtgt tccagccttg aaataagtac tgcatggcaa ctgaaatttc tccgaattgc 454381 ccgcctaaaa tttcttgcat ttttttagcg aataatggat ctggacgatc tggtttagca 454441 ggatgctgca gcatttttgt gtgcttaaac atgtacccat ctcctttttc gtttatctct 454501 ttttatattt ccgatcgata gaaagataaa cgaaaaacag cgtatcgaga tgggaactat 454561 gaatcttttc gcagctccaa cagttcccgg atcagctccc ggccaaagat gggctcatac 454621 tgccggtaaa cagggtcaag acgcttcatc cattcttgtt tctctttatc tgacagctca 454681 taaatatgta tagcagaatt ctttttgatt tcttccagct gctccttgtt catttgttcg 454741 gcatacgttt cattccactc cgttgtctcc ttcatcgctt cagtcaaaat gcgtcttgtt 454801 tctggtgttt gcgccttcca gaagtgttca tcagtcatga cagcgtagcc gagataaccg 454861 tggctgctta ttgtcaaata gtcctgaaca ttataaaatt ttttagaata gatgtttgaa 454921 attgtatttt cttcgccatc gactacattg ttttctaaca gctgaaaggt agaattgaag 454981 gattcctgat gaggtgttgc gccaagcagc ttgaactgat cctcaatcac atcgctttgc 455041 ataatgcgca gatcctgccc ttttaagtca tccggtgttt tgaccggccc ttgatttgtt 455101 gtgatttgct taaagccgtt cgtccaatag gccaatcctt tcaattggtt tttctttaga 455161 gaatcaaaca gctgtgtgcc gatgcttccg ttcagccctt ttttgacggc gttgtaatct 455221 gtaaatgcat acggcagatc cagcactccc cattcaggcg agagcatgcc gagcttcgat 455281 gtggaggggg cgataaattg aacatcgccg ttttgcaatg cttcaatttc ttcaatgtcc 455341 gagtacaggc ttccattcgg aaatacttct atttttattt ttccgcctga tttttcgttc 455401 accagatcag cgaatttatt ggcggccagc ccttttggcg tattttcagc aaccacgtgg 455461 ctgaatttaa acacgatttg atcctgcagg ccttcctggt cgtcatcata aacaatcttt 455521 ttattgccgg tatgatcatg gaatccgata aataaagcgg ttgcaattcc agcgatcatc 455581 agtgcgagac atgcaagcaa actcttcatg aaaagccctc ccctatgtta aggataatgg 455641 gggctatgac attcgtaaag acctgaaagg agaagctgat gaacaaaaag aagctctcaa 455701 tccgttggaa aatcacgatc ttatcctata tactcgtcat tttctccttt ttgatcggcg 455761 gcattgtgct catcggcaac attcagcata cagaggagcg ggagctgaaa aagcggctga 455821 tgaatacggc ccggacggtg tcagagatga cagaagtgaa agaagccttg gcgcgaaaaa 455881 aacaaacaga agcggttcgc catgcggttg aagaaatcag gatgattaat gaagcagact 455941 atattgtcgt catggatatg aatcacatcc gatatacgca tcctgtcagc acaagcattg 456001 gcaagaaatc agaaggtgca gacgaggagg cagcttttgc ggagcacatt tatttctctg 456061 aagcaaaggg cgagatcggc acggcggttc gcgcttttta tccggtaaag gatcaagacc 456121 tgaaccaaat aggcgtggtg cttgtcggaa aaacgctgcc ggggatcgct gacatcctgc 456181 ttcatttaaa gcgtgatatc gccttcatcg ttgtgctgac actcggcttt ggccttgctg 456241 gttccttttt gctggcccgc catatcaaaa aacaaatgtt tcagcttgaa ccccatgaga 456301 ttgtccgaat gtatgaagaa cggacagcga cgtttcactc gatgaatgaa ggggtgatcg 456361 ctattgacaa tcgtctcgtc attacgatct tcaatgaaaa agcgaaacag atctttgaag 456421 tgcaggggga tctaatcggc aaggtgattt gggaggttct caaggattcg cgcctgcccg 456481 aaatcgtgga gcggaacaaa gcggtttata atgaagaaat tcgtgtcagc ggtaaggtga 456541 tcatgagcag cagaattccg atcgtcatga agaaaaaagt gatcggcgcc gttgcgattt 456601 ttcaggacag aacggaagcg gccaagatgg cagaggaatt gactggtgtc agaaactttg 456661 tggaggcgct ccgtgtccaa aaccatgagc atatgaataa gctgcacacg atcgccggtc 456721 tcatccagct ggggaaatct gaaaaagcct tgcagcttgc attccaggcg tcaactgagc 456781 aggaaaatgt gactgaattt ctgcaccgct cgattcaaaa tgacgctgcg gcaggccttc 456841 tattaagtaa aatcagaagg ggaagagagc tcggcattgc tgttcatata gatgaaaaca 456901 gcagtcttca gcaatttccc gagcatgttg atcagcatga tattgtcgtg cttttgggga 456961 atctgattga aaatgccttc ggctcatttg aaaccgttca atctgaagac aaacgaattg 457021 acattagtat cgaacaaaca gatgatatcc ttgctatttt aatagaagat aacggctgcg 457081 gaattgaacc gacacatatg cctcgccttt atgacaaagg ttttacggtc aataaaactg 457141 gcggcacagg ctatggcctg tatctagtga aacaaatcat agacaaagga tcgggcacga 457201 tagaagttga ttcacatgcg gggcagggga catctttttc tatcgttttt ccaatgaagg 457261 gggaggaagc acagcatggc tcgtaaagaa tggaaggttc tgctcattga agacgatccg 457321 atggttcaag aggtcaataa ggatttcatt acaactgtta aaggcgttac tgtctgtgca 457381 acggcaggaa acggagagga aggcatgaag ctgattaaag aagaacagcc agatctcgtc 457441 attctcgatg tgtacatgcc gaaaaaagac ggcatcaaga ccttgcagga gatcagaaag 457501 caaaagcttg aagtggatgt cattgtcgtc tccgctgcaa aagacaagga aacgatctca 457561 ctcatgctgc aaaacggggc ggttgactat atcttaaagc cgtttaagct tgagcgaatg 457621 agacaggcac tcgaaaagta caagcaatat aaacaaaaaa tcgaagcgaa tgatacgctg 457681 tcccaggaac agctcgatgc gatcctgaat attccgcagc aggccgtaca ggatctgccg 457741 aaagggttga atcacttcac gatgaatgaa gtcactgctt ttttgaaaca gcaaaccgca 457801 tccctttctg ctgaagaggt tgccaaggcg ctcggcatcg ccagagtgac agccagacga 457861 tatcttgatt acttagaaaa aaccgggatc atcaaattgg acgttcaata cggcggagtc 457921 ggccggccgg tcaaccgcta cgtgttaaaa ggataaacct gagaccaaaa agaccaaaat 457981 gtccgttatg atcataaact tccccagact gtatgaaaac gctatcattc tagtaagaaa 458041 gacacaaaag gcgaatagga cagggggatg aaggatatga aactgtttaa aaatttaaca 458101 gttcaggtca taaccgcggt catcatcggg gtcattgtcg ggctggtctg gccggatgtc 458161 ggcaaagaaa tgaaaccgct tggtgataca tttatcaacg ctgttaaaat ggtgatcgca 458221 ccaatcattt tcttcacaat cgttctcggg attgcaaaaa tgggcgatat gaagaaggtt 458281 ggaaaagtag ggggaaaagc gtttatctat ttcgaggttg tcaccaccct cgcactcatt 458341 atcggtttat ttgtcgtcaa tattatgaag ccgggtgcgg gtcttgatta cagcaagctt 458401 gaaaaaggag atgtatcaca atacacgcaa aatggcggtc agggaatcga ctggattgaa 458461 tttattacac acattgttcc gtccaacatg gttgatgcct tcgcaaaagg ggacattttg 458521 caggtcttat tcttttctat tcttttcgga gtgggtcttg cggcattagg cgaaaaagga 458581 aaaagcgtca ttgatttctt cgacaaggtt tctcacgttt ttttcaaaat tatcggctac 458641 attatgcgtg ccgcgccaat cggggcattc ggggcgatgg cgtatacaat cggacacttc 458701 gggctcgatt ccatcaaacc gctggcaagc ttaatgatgt ctgtttatat tacgatgttc 458761 ctgttcgtat ttgttgcttt aaatatcatc tgcaagcttt acggattcag cctgtggaat 458821 taccttcgct tcattaagga tgagcttttg atcgtgcttg gcacaagctc ttccgaatcg 458881 gtgcttccgc gtatgatgga taaaatggag cgctacggct gttccaaatc cgttgtcggg 458941 cttgttattc cgacgggcta ttcgtttaac ctcgacggca catccatcta tttatcaatg 459001 gcgactgtct ttttggcaca ggtgtttgga gtagacctca gcatcggcca gcaaattacg 459061 attatcctcg ttctgatgct gacatcgaag ggagcggcag gtgtgacggg aagcggattt 459121 atcgtccttg cctcaacgct gtcagcgctg caggtcattc cgctggaggg gcttgcactc 459181 ctgctcgggg tcgaccgttt catgagtgaa ggaagagcca ttgtgaacct gatcggaaac 459241 ggaatcgcca cgatcattgt tgccaaaagc gaaaatgaat ttgatgaagc aaaaagcata 459301 gaggctgttg aaggcatgaa aaaaatgaaa acagcagtct gaaaaaagaa cggcccatcc 459361 atgggccgtt tttttaattg tttaagaatt attaaggtaa ggacagagac ctcagcattt 459421 ttttgttata taatttacaa atggatacta tattgaatga aggacgtttg tcctaacagg 459481 agtgtataaa tggccgcttt agttaaattt tttcagcacc cgggagtaag gcgtttctcc 459541 atctttgtcg tgttaactgg tgtgttatat ctatttaaga gcatgatcaa cttaatattg 459601 cttaccttca ttttcacatt tctaatggat cgtttggagc ttgtcgtgcg gcagtttgta 459661 agccagttct tccgcgtgag ccagcgggtt gtcattacgt ttctttacat gttgctggct 459721 gtgctgctta cagtcggggg ctttgtgttt tatccggtcg tcgcggcgca gatccagcag 459781 ctggtaaagc agattaaaca tattgcgtat catcctgaca gcatcccttt ctttgatgag 459841 atcaccagtg tcttcggaga tattaacatc agttcatatg tcaaagaggg cttcaatgta 459901 gtgtatacgt atctggccga tatcagcaca ttcggcttgc aggtcgtgat ggcgctcatt 459961 cttagcatgt ttttcttatt tgagaaaaaa cggctttctg aattcatggc gaaatttaaa 460021 acgagcaaac ttagggtctt ttatgaggag attgcttttt tcggaagcaa atttgcaaga 460081 acgttcggca aggtgctcga ggctcaattt atcattgcgc tcgtcaactg tattctgacg 460141 tttatcgcgc tttggattat gcattttccg cagctgtttg ggctttcgat tatggtgttc 460201 ttccttggat tgatccctgt agcaggcgtc gtcatttccc tgattccgct cagcattatc 460261 gcctacagca ctggcggtgg aatgtatgtg ctctacattg tccttgtcat attcgccatt 460321 catgcgatcg aaacctattt cttaaatccg aagctgatgt cggcgaaaac agagctgcca 460381 atctttttca ccttcacagt actcattttc tctgaacact tcttcggcat ttggggttta 460441 attatcggga ttccgatctt tgtgtttctc cttgatattc tggatgtcac caacaaggaa 460501 gataggtcta aaggaccccg agagaatagc gataaaaagt agtttaaaat cgaataatga 460561 gtgtgcctcg atctgccggc ctgcctgttc agggcatgga attaagactc ggaatcggag 460621 cttggcattg ccttgcacag tggtgaacac aacaggtgac aatgcttgtc atcagtacgg 460681 aaactgaaaa gaacaaacag tcggagcaaa cgctcatcat cggtttaacc aaacatttgg 460741 aagcaacaaa tgctataata caaacagtgc ctaatgttgg gcactgttta ttttttgtcg 460801 aaaaaggagg aaggctttat ggctgagccg attttacata ttgaaggcct cgataaaaaa 460861 attgggtcta aacagatttt aaaacagatc agcatggacg tcatggaggg tgaaatcatc 460921 ggccttctcg gtccgaatgg ttccggaaaa acaacactca tccgtatcat cgtcgggctg 460981 ttgaaacaaa acagcggaag cgtgacaatc agcggattcc agcatgatac agagtttgaa 461041 aaagcgatgg aagcggttgg agcgattgtt gagaaccctg agttctatcc gtacctgaca 461101 ggctgggaaa acctcaagca ctttgcgaat atgcacaaaa aaatagcgga tgaacggctt 461161 gatgaagtgg tggaacgtgt cgggctgacg tcagcgattc atgataaggt gaaaacctat 461221 tcccttggga tgcgccagcg tctgggaatc gcccaggcaa ttcttcaccg gccgaagctt 461281 ctcattctag atgaaccgac aaacggcctc gatcctgcgg ggatgaagga ttttcgggat 461341 catattaagg aactcgcaga aatggaagga acagctgtcc tgttcgccac tcatttattg 461401 cgcgaggttg aagacttgtg cgaccgtgtc atcatcattc aaaaaggtga gatcaaagcg 461461 gaagtcagct tacaaggaac cgatcaaacc acagaaaaag cgattataga agtgcagccg 461521 caagaaaaag cgctcaattg gctgacaggc aatcaatatc aagctgagag ccaagacggg 461581 acgattgtag ttgaggtggc aaaagaaaac ataccggagc tgaaccgatc acttgtcgga 461641 caagatctga atgtattttc cattacgcct tacacgcagt cactggaaga cgaatttata 461701 aaagcgacaa cagctcatca agaggaggga gaagagcttg tctaaattaa tttggaatga 461761 acatatgaaa ctttttaatc ggaaggtcac tttggtttct cttatcctga tggctgtctt 461821 tcaattcttc atggcattga tcattaaacg gattgtcatc agtgccggaa cagatgaaaa 461881 cttcatcggc tatttatcgt atacaccgag cctgaacatt ttgctgcagg ctttaacgat 461941 cgtaattgca gcaacaattg tttcgatgga atttgataaa aagacgatca aatttttgct 462001 cattcgtccg gttaaacgcc aaaaggtctt ttggtcaaaa ttaatcacag tcgtgatggt 462061 cagcttctat ttgtatttgg catactacat tctggcatta ttattcggtc tcttgttttt 462121 tggcacatcg gtgactgcgg aatcaaagac attgctggtc aacaccttgg cgctgatcgg 462181 gtcaaactgg cttgaagctg taatgatggg attattcggg ctgctttgtt cttcgctgtt 462241 ccgcaatagc gcggtagcag ttgttgtttc ttttgtcgtt ttatacggag cgagtacact 462301 tgttcagctc atgaagttgt ttgaaaacaa gtggggcagc tttttgcttt ttgcgaacac 462361 tgactttacg caatacagaa gcggagagac agcgttgttt tcaggcatga cgccattgtt 462421 ttcaattgga attctcatca tacatgccat attcttcatc gttgttggct ggtggtgctt 462481 ctgtaaacgg gatgttcggg tctaaaggca aggaatgaca tttttgtgaa aaagctcacg 462541 taaatcaata tcatttgata ttttggttta tactaaaggt actgacggag gtgtctcgat 462601 tgaggaactt tattaccgct ttaccgatcg tattgctgct tggattctca tttgtgtcat 462661 tcatgtttca gtttgaacat cttgtttatt tcaggctcgc gcttgggttg ttttctctcg 462721 tgggactgta catgatatat aaaatgaaga cgggcatccg ctattttatc atctatctgt 462781 atgccagctg gattgtgttg gccgcagtga ccgcttttga agagccgatt ttctcaagct 462841 ttttctttgg cggcctggtg atgacgatgg gttacctgac atatatgctg atttatctcg 462901 gcatgaaaca agaccgggat gcaaatcctg tgtaatcgcg ctgttccctt ggggaacggc 462961 gtgtttttct atactgggca aaaggttaac agttgcggaa aaatggcagg aaatctataa 463021 tacatattaa atttatcgga attaaaactg gggggctgcc ggatgtcatt atttatacaa 463081 aacgatcaac agcggcaatg gatggagaaa atcggacgga ttgcggatga atttcagcaa 463141 acagctgctg aagatgacga acagggacgt tttcctgcag agaaaataca aaaactgcgt 463201 gatgctgggt atacagcatt aacattgccg gcatctcatg gcggaggggg catttctgtt 463261 tacgatatgc tcttgtttca agaacggctt gcacggggag atgctccgac ggctcttagc 463321 atcggctggc atttgagcgt gatcggggag cttggagaag gcaacagctg ggatgaagac 463381 gtatttgcat ttgttgccaa ggaagtccaa aacggagccg tcattaacag ggcggcgact 463441 gaagcgaaaa ccggaagccc gacaagagga gggcgtcccg gtacacacgc cgtcaaaaag 463501 gatggcaaat gggcagtgaa cgggagaaaa acctttacga cgatgtcaca agctctggat 463561 tattttttag taaccgcatg gattgaggac aaacaaacaa caggcgtgtt tctcattcat 463621 aaagatgatc ccggcttgtc gattgaagaa acgtgggata tgatggcgat gcgggcgact 463681 gggagccatg accttgtact gaacgaagta atgcttgatg agaataagct ggtggaactg 463741 cttcaagggc ctcgtggagc taagccgaat ggctggctgc ttcacattcc tgcgatttat 463801 cttggtgtgg ctcaagctgc tcgtgactat gcagtgcaat ttgcatctga gtattctcca 463861 aacagcttga atggaccgat caagaatgtc ccggccgtac agcaaagaac aggcgaaatg 463921 gagcttgaac tgctcaatgc cagacacttt cttttccata tcgctcaatt gtatgacgat 463981 ccggtgcggc gtccacactt gaccagcgag ctcggtgcgg cgaaacatat cgtcacaaac 464041 gctgcgctgt ctgttgttga taaagcgatg agaattgtcg gggccaaaag cctggaacga 464101 accaacccgc ttcagcgcta ttaccgtgat gtgcgcgccg gtcttcacaa cccgccgatg 464161 gatgacgccg tgatacacaa gctggcagct gaagcgtttg agtcataaaa aaaagagcct 464221 taccggctct ttttatgtat tgttttgctc ttgcagattt ttttgatgct tgcggtcgat 464281 cctgtcataa ataacgttca tcagctttgg attgcccata atcgcctctt tgttttcctg 464341 gatcagctgt tggtaagttt tcactttacg cttcggcatg ctccggcgcc ctcctgacat 464401 gtttgtattc actttctaac tccgtcagcg acaattcata cagatgacgc tttgactttt 464461 tgtatatacc attctgtatt aacagatgaa tgagctgttt ttttctgatt tctgcagact 464521 gaggtgtcat tgtgtcacca acctccaatc aaacgatatt gataatcatt atcaattaac 464581 ttcagtatac aatgtccgca atagcctgta aagatgaaaa gagtcctatt cttggccaat 464641 ttacaaacat tcaacaaatc gacaaaaagt ttcccgggca ataatttgct gtcgaaatat 464701 tccgcttcat tgaacgcacc ctgctatttt tcatgttttg aaccatacta tgtaatagaa 464761 tggaggctgg tattcaatgg agcggacaga aaatctgaaa aagggagaaa aaggggcgct 464821 cctcaatatt tttgcatatg tcatccttgc tgttgtaaag ctagttatcg ggattctata 464881 tcattctgaa gcgctgagag cagacgggtt aaataatgga acagatattg ttgcgtcagt 464941 agcagtgctg ataggattgc ggatttctca aagaccggct gacagcgatc atccatacgg 465001 ccattatcgg gctgaaacaa tttcgtctct tgttgcgtct tttattatga tggcagtcgg 465061 cattgaagtg ttaatcggcg gaggaaaagc gattgcgggc ggcacaacgg aaacgccaaa 465121 tcttatcgcg gcatggacgg cgttaggcag tgctgtgttt atgtatggca tctatttata 465181 taacaaaagg ctggcagcgt ccattaaaag ctctgccctg atggcagcgg caaaggacag 465241 caggtcagac gcttttgtaa gtgccggcgc gtttatcggt gttttttcgt cccagctgaa 465301 gctgccgtgg gttgatccgg taacggcttt tatcatcggc atcatcattt gcaaaactgc 465361 gtgggatatc tttaaagacg cttcacattc cttaacagac ggcttccatt taaaagatct 465421 tgagccttac aaacagaccg tcggcaggat cgaaaatgtg catcgcctaa aggatgtgaa 465481 agcgaggtat ttaggcagta cagttcatat cgagatggtg attacggttg atccgaagct 465541 tacagtagaa gaaggccatg gagtggcgga tgaagtagaa gacaaaataa aacatgaaca 465601 cgatgtcact catgttcatg ttcatgtaga gcctgacgac ataaaataag gctgtttaac 465661 gaattagctt atatgttcag ataaaaattc agtcacttct tcaggcgttt tggcattggc 465721 gctgtgaagg tgagctgttt tttcaccgtt cttgaaaata agcaggctgg gaatgcccat 465781 tacttggtat ttttcagcca ggtcaggaag ctcgtcctta ttcagctcat accagtcgtt 465841 ttggttgtat tcttccaaaa tatcgccgat gaacatattc atgcgtgtgc agtctgggca 465901 ccaatcagca taaaacttta caatgatttc tttatcagat tgaatcagtt cattaaattg 465961 ttcgtttgtt gtgatttttt tcatatgtca catctccttt tcaatgccat tttaatataa 466021 aataaaaagg aattacatac aaatgcattc aacatcagca tgcccaaaaa taattagatc 466081 attttccggt gaaaatgata agatagtaaa gatgaattgt agtgggggga gtatccattg 466141 aaaacaagtc taggattagt gtacggagga aagtcggcag aacataatgt ttccctgcag 466201 acagctctgg ctgtaatcaa agcgctaaat actgagaagt ttgatataca tccgatttat 466261 ataacagaaa aaggcgaatg ggttagaggc gcccgtttaa ctgaacctgt ttcaaacgtg 466321 aaaatgcttc aatttgagca aggaggcagt gctttttctc cagctgccct gaaccaggag 466381 atgtttccgc aggaagcgtc acagcaaaat gaagccatcg acgtcgtatt cccgctcctc 466441 cacggaccga acggagaaga cggtacgatc cagggaatgc tcgagctgtt gaacattcct 466501 tatgtcggca acggagtgct tgcttcctca gctggcatgg ataaagttgt catgaaacat 466561 ttatttgcgc aggttggcct tgctcaggct aaatacgcag ctttccttaa gaaagactgg 466621 actcgttctc cgaaagaaag ctgtgaggag gttgaacagg aattaggcta cccttgcttc 466681 gtaaaaccgg cgaacctcgg ctcaagtgtc ggaatcagca aatgccgaaa ccgtgaagaa 466741 ctgcaaaaag cgtttgagct tgctttccaa tatgaccgca aagtcgtcgt tgaagaagga 466801 attaacggcc gcgagatcga aatcggcgtt cttggaaatg atgatcctaa atgctctgtt 466861 gtgggagaaa tcgcaccgaa gacagatttc tacgattaca aagcgaaata tgaggatgga 466921 gatactgatc tgatgattcc ggcgattgtg actgatgagg aatacgcaac aatcagtgat 466981 atggcgatca aagcgtttaa agcgatcgac ggttcaggac tcgtcagagc ggactttttc 467041 ctgacagctg acggcgaagt tctgatcaat gaagtcaaca caatgcctgg ctttacacct 467101 ttcagcatgt tcccgttgct ctggaaagaa gccggagtgg aatatgctga cctgattgaa 467161 cagcttgtgg agcttgcaaa agaacgccac gctgaaaaac aattgattaa gcatacattc 467221 taatgaagaa ggacactgcc ggtaaaaggg cagtgttttt tcccgtatat acaaaagaaa 467281 gagagggacc ttacttgatt aagcgaacag taaaaaacat tgccgaaatg gttaaaggca 467341 cactagcaaa tccgcaatat gaacaaacag tcattcatgg agtggcaacc gatacaagaa 467401 aactggaaca acatcagctc tttattccgc tgaaagggga acgttttgac ggccactctt 467461 ttgtggagca ggcctttgaa gctggtgtag cggctgttct ttgggatcgg tcagtaccaa 467521 atccgcccga gaatcacgcc gtcattttag tggacgatac ccttactgca cttcagcagc 467581 ttgcaaaagc ttatttgcag gagcttggca cgcgtgtcat cggagtaacc ggaagcaatg 467641 gcaaaacgac aacaaaagat atgattcacg ccgtattggg gacccagtac cgtgtccaca 467701 aaactggagg aaacttcaat aatcatatcg gtttgccgct gacggtttta gcgatgcctg 467761 aaaatacgga gatcgccgta ttggagatgg gaatgagcgc caaaggagaa attgacctct 467821 tgagccgact ggcaaacccg gatgcggcag tgattacgaa tatcggcgaa tcgcatatgc 467881 aagacctcgg ctctagagag ggcatcgcgg aggcgaagct tgaaatcata aacgggctta 467941 aagaagacgg agtgctgatt tatatcgggg acgaaccgct tcttcaaaat gcatacagct 468001 gccagacgaa aacgtacggt acgggaacgc ataatgatta tcagcttcag gatgtcagcc 468061 agagtgagga aggaacccat tttacaatca aagggataga aaacacgttt tttattccaa 468121 tactcggcaa gcacaatgtg atgaacgcca tggctgcaat tgctgcaggg gcttattttg 468181 gcatcgcgcc tgaggatgcg gcaaaaggac tgagcggcct aaaggtaacc gggatgaggc 468241 ttgaactcat caaaacagac agcggccttt cgataatcaa tgacgcttat aatgcgagcc 468301 cgacttccat gaaagctgca attcaattga cagaaagcct tgaaggctac ggcaaaaaaa 468361 tgctcgtgct cggtgatatg cttgaactcg gcgatcttga agaaacgttc cataaagagt 468421 gcggcgctgt gatcagccct gataaaattg accgcgtctt tacgtacgga aaactgggag 468481 cttttatcgc ggaaggcgcc ctgaaacact ttgagaaaga ccgcgtcagc cattacactg 468541 agaaaaaaga tctccttcaa gctgtgaagg aaaacgcatc aaaaggcgat ttgattttat 468601 tcaaagcgtc cagaggtatg aagcttgaag aaatcgttaa agatttaata gagagcccgc 468661 tttcataaga aaatattttg cgaaaaaacg catattgcat cataaaataa cctgatatgc 468721 aaacactaat gtatgccggc cgaaaattat gtatatctgg ccggctgcgg ctatgataca 468781 atatatatag gttatttcgc gatacgaaca tattcgtccg gacttttcat cgtgacccga 468841 agttctccgc tggattcttg ggagcggatg gagcagcagc cggcatattc gagatgccga 468901 tctgcttctc atcttattga aaaacaaata gtgtaatggt aagataaaac ttaaagtaat 468961 tcgggctttg tatacggatg gatcctgtcc ttcttgtcta aagggcagtt ttataagtgg 469021 taaatcacga cattactgaa acagcaatta gaaggagttt gaataatttg actataacgt 469081 ttcaagattt taatttaagt tctgatctca tgaaagcaat taatcgtatg ggatttgaag 469141 aagcaacacc gattcaggca caaacgatac cgctcggact ttcaaataaa gacgtcattg 469201 gacaagcgca aacaggtaca ggtaaaacag ctgcgtttgg tatacccctt gttgaaaaaa 469261 ttaaccccga gtctcctaat attcaagcaa tcgtaatcgc gccaacccgt gaattagcca 469321 ttcaagtatc tgaagaattg tataaaatcg gacaagataa acgtgcgaag gttcttccta 469381 tttacggcgg acaggatatt ggacggcaaa tccgggcgtt aaagaagaat ccgaatatta 469441 ttgtcggaac acctggacgt cttcttgacc acatcaaccg ccgcaccatt cgtttaaaca 469501 atgtaaatac cgttgtaatg gatgaagcgg atgaaatgct gaacatggga ttcattgacg 469561 atattgaatc tatcctttca aacgtgccaa gcgagcatca gacacttctg ttctctgcca 469621 caatgcctgc gccgatcaaa cgcattgcag agcgcttcat gactgagccg gaacacgtaa 469681 aagtaaaagc gaaagaaatg acggtttcta acattcagca gttctatttg gaagtgcaag 469741 aacgtaaaaa attcgataca ctgactcgcc ttcttgatat tcagtctcct gagcttgcga 469801 tcgtattcgg acgtacaaaa cgccgtgtcg atgagctggc tgaagctctg aaccttcgcg 469861 gatatgcagc tgaaggtatt cacggtgact taacgcaggc gaaacgtatg gttgcgcttc 469921 gtaaatttaa agaaggcgca atcgaagttc tagtcgcaac tgatgttgcc gctcgcggac 469981 ttgatatctc aggtgttaca cacgtataca acttcgacgt gcctcaagat cctgaaagct 470041 acgttcaccg tatcggaaga acgggccgtg caggaaaaac aggtatggcg atgacgttca 470101 ttacaccgcg tgagaaaagc atgcttcgcg caattgaaca aacaacaaaa cgcaaaatgg 470161 accgcatgaa ggagcctaca cttgatgaag cgttagaagg tcagcaacag gttactgttg 470221 aacgtcttcg cacaacaatc agtgaaaaca acctgaactt ctacatgaca gcggcagctg 470281 agctgcttga agatcatgat gcagtaacag tggttgcggc ggctatcaaa atggctacaa 470341 aagagccaga cgacacaccg gttcgcttaa cagacgaagc gccgatggtc agcaaacgct 470401 acaagaacca gcgctcttct aaacgcagag acggtcaagg cggcggctac cgcggcggaa 470461 aagggaaaag caacaaccgt tcttcctatg acaaaaagcg ttcaaacgat cgccgttctt 470521 caggtgacag acgccagaaa aaatcttact aatttgatcg attcagagcc caaaacatga 470581 tgttttgggc ttttttatgt tcgtgatttg ttattcagca aactttcagc tgacggaagc 470641 catttttctc tgtatgctta agaatgaaac ctttctgtaa aagagacgta taaataacga 470701 cgaaaaaaag ggaggtaggt atttttgaga gagcagccaa aaaaccaaat cagtccagac 470761 ggattaaagg tttggcgact tcaagagatc atcatatccg ctgtttgctt gcttattgtc 470821 attgcagttg cagtgttaag ctattatttt cattggccgt actggatcag cggcgtgctc 470881 ggcgctgttt ggctgctggg atcgattgtg acggtcttta tcattccgaa ggtccgtcat 470941 aaggtgtggc gatatgaagt ccatgaacat gaaatagata ttcagtcagg tatttttgtg 471001 gtgacacgtg tgattgttcc gatggtcaga gttcagcacg tcgatacgtc acaagggcca 471061 ttattaaaaa aatacaacct ggcaacggtg aaaatttcca cagccgcgac cgttcattcg 471121 atccccgctt tagagatgga ggaagcggat cggctaagag actccatttc ccgtctggcg 471181 agggtgactg acgatgatgt ctgaaccgaa acgcctgcac ccggtggcag tcattttgaa 471241 tttatgccat accattattc aaacgataaa aaatatcatt ctgccattct tttttgtgta 471301 tattgtcaat tcaaaccata ctgtccgttt ttacggagcc attgcgctcg gtgtgctgtt 471361 catctggctt gtagcggcaa gcattatcaa atggagaagg tttacctatc gaattgaaga 471421 tgatgaattt agaattgaag aaggcttatt tgttacgaaa aaacgataca tatcgattga 471481 tcggattcaa acaatgaata cgagcgcggg ccttgtccag caaatcttta agcttgtgaa 471541 gctgcaaatt gaaacagcag gcggaggcaa ggaggcagaa gccgttcttt ctgctatttc 471601 tgttgaagaa gcggaacgca tcaaagaagc tgtctttaag aaaaaagcgc aaagacgaga 471661 aaatgaactt gatgaagaac ggcttgaagc tgaagaggag ttggatccgt ccgttgaggt 471721 gcaagagcac tatcgcatga acgcgaaaga attgctcatg gccgcttcta cctccggcgg 471781 aatcggagtc attatctccg ctgtatttgc acttatttcc cagcttgatg aagtgctgcc 471841 gatggattgg ttattcgata aattttcctt ccttcagcac gccagcatcg gtatttatgc 471901 ggtactcatt tttatcggtt tatttatcgc ctggattttc agcatcgcgg gcatgatgtt 471961 tagatacgcg aactttcaaa tcataaaaaa agagcaggaa ctggtgattt caaggggaat 472021 tattgaaaaa catcaagtca cgattccgct gcgaaaaata caagccatta aaatcaaaga 472081 aaatatcatt cgccagcttt tcggctttgt aacggtgtcc atcgtcagcg caggaggcgg 472141 cgaccgggaa aaagaagaag gcgctttgac cattctcttt ccaatgattc ataaaaaaaa 472201 gcttccgcac atgctccgaa catttacgcc ggaatacacg ctggaagaaa actgccgccg 472261 cctgccgcgg cgcgcgttga aacgctattt gttccgttct gtcatttttt cactcttttt 472321 gatcatcccg ttatgtatct tctttcagcc atggggctat ctgtcagtga tcctgctgcc 472381 gatagaattg ctcttcggct atctcgcgta taaagaggct gcatggacga tcaacgggga 472441 ccgtcttcag ctgacgtcta gatttatagg cagaacaacc gccattgtac tgaaaaaacg 472501 aatgcaggtc tgcaagttca gccaatccta tttccaaaag aaaggccgct tgtataccat 472561 ttctacttcg gtgaaatcat cgagccatat ggaagagtta acggtgaggg acgtaggtga 472621 agaggatgca gccttcattt taaagtggta ctcatatgaa aaagcggacg gttaataccg 472681 ccgctccagc gtgtcggcaa accctcgcat tcgttgtcag gactgcgctt cggtgctcaa 472741 tgcgaagtgg atcaacggct aaattctcag gcgtcctgcc taaacgccgt cgtcatcaca 472801 tcctgtgaaa gtccgctcct atgctcgtcc ttcctagact tcatgggttt tcaatcacgc 472861 tgaaaagatg acaaaatcct aaaatgaaaa ccattttagg attttgtcaa caatctgaag 472921 cggcggttaa taccgccgct cttttttttg cacgcataaa aacgaaagaa gaaacccgcc 472981 gcatagtcca aacaaatggg ccatcatgtt aatattggag ttgataaacg acatgagaac 473041 ggcaaatgcg agcagtgtga tgatcatttt ggaatgctcc tgcccaatta actcattgcg 473101 aaaaagaacc ataaacaggt atacgccaaa tagcccgaaa atggcgcctg aagccccgac 473161 atgcacgtaa tcaagcggct ctgtaacata agtgccgata ttgccgatga tgccggagcc 473221 ggcgtataca agaaggaaac gcgcttttcc cagcatgcgt tccaaagccg gggcaaataa 473281 aaagatggac atggaattaa acagcagatg tgtgaaaccg gcgtgcagca aaatcggtgt 473341 gataagccgc caccattcac cgtttgcgac acctagatta tagcctgtga cggtatccct 473401 ccataacacg actgaatggg caggaagtga aaaaaacagc cagagaacag cttgcaaagc 473461 caatataaag gtgacaacgg ggtaaagcct gataaatgtt tgaaaatttt cagtccgtat 473521 aaacattccg agcccctttt cttcattttg gtatatctat agtaacacgt ttatgagaca 473581 aaccatttaa atagtacgta cgcaaaggag gttatcatac atgatttacg gcattgggct 473641 ggacattacc gagcttaaac ggatcgcctc tatggctggg cgccagaaaa ggtttgccga 473701 gcggattttg acgcgaagcg agcttgacca atactatgag ctttcagaga aaagaaaaaa 473761 cgaatttctc gcgggcagat tcgcggcaaa agaagcgttc tcgaaagcat ttggcaccgg 473821 cattgggagg cagctcagct ttcaggacat tgaaattagg aaagaccaaa atggcaagcc 473881 ctatatcatt tgtacgaaac tgagccaggc cgccgttcac gtatcgatca ctcatacaaa 473941 agaatacgct gccgcgcagg ttgtgattga aaggttgtca agctagtctg catattaggg 474001 aaaccccact catatatttg atagtgcatt aagggagaca agttgtttga ggcttttatg 474061 gtacgcatct gttctgccta aacgtgtacc gagcgtaccg ttaaagtcaa acaagcgatt 474121 tcttcctttt acatcaattg agaaaaaggg gttgaaaaag gtgagaaaaa gctttgtttt 474181 gcttttaacg ggactgcttg ctgttcttat tctttctgcc tgcgggcaaa aaacacagca 474241 agatattgtg gccgggttag atgaaaaggc gaaagaatac acctcgtaca aagcaaaagc 474301 gaaaatgacc atcgagacag ggagtgagcc tcaagtatac aatgtggaaa tctggcacaa 474361 aaagccgtct ctgtacaggg tttatttaga aaatccgaaa aaggaccaaa accaagtcat 474421 tttacgaaat gaaaacggag tattcgttct cacgccgtct ttaaataaga gcttcagatt 474481 tcaaagcgat tggccgaaca acagcagcca ggtttatctg tttgaatcgc tcgtaaagga 474541 tgttcaaaac gattcggatg cagttttcac agcgaaagaa aagaaatacg tatttgaaac 474601 aaaaacaaac tatcagcata acaaaatgct gcccacgcaa gaaatcacat ttaacaaaaa 474661 agatatgagc ccgtcatctg tcaaagtgat ggatactgac cggaaagtga tggtcaaagt 474721 agaattcagc agctttgaat ttaataaaca atttgataaa gaatcatttg atgaaaagaa 474781 aaatatgacc ctttctcaaa tggatgtcgc cacaagcgca aagccttccg atacatttgc 474841 ggtcaaaacg ccgctggaac tgccgcttgg cgtcaagctg cttgaagaaa aagatatatc 474901 tactgaagac gggaagcgca tcatcatgac gtacggagga gaaaaatcat ttacgttaat 474961 tcaggaaaaa gcccagattg ccaaggcttc ctcctccgtt acgctgaacg gcgaaccggt 475021 aaatctcggc tacaccatcg gcgccctgtc ggatgcatca ttatcatgga catatgacgg 475081 cgtagattac cttctctctt ctaaagatct ttctaaagag gaaatggtga cagtagcgaa 475141 aagcatgcag ggacaatcat cgaaataacc gccaaaggcc aaacatgatt tggccttttt 475201 ttcgttagac atcgtttccc tttagccttt aattttagta tgatatgtaa atgatattga 475261 ataaaagcta ggaagtgtcg taatgagcac aaaacctttt tacagagata cgtgggcgga 475321 aattgacttg tccgcgataa aggaaaatgt cagcaatatg aaaaaacata tcggtgaaca 475381 tgtccacttg atggcagttg tgaaagcaaa cgcctacggg catggtgatg cagaaacagc 475441 aaaggctgct cttgacgcag gtgcttcatg cttggccgtg gccattttgg atgaagcgat 475501 ttcactgcgc aaaaagggat tgaaggcgcc tatattggtg cttggcgcgg ttcccccgga 475561 gtatgtggca atcgctgctg agtatgacgt gaccttaaca ggttattctg ttgaatggct 475621 tcaggaggca gcccgccaca cgaaaaaagg ttctcttcat tttcatctga aggtcgatac 475681 ggggatgaac agacttggtg taaaaacaga ggaagaagtt cagaacgtga tggcaattct 475741 tgaccgcaac cctcgtttaa agtgcaaagg ggtatttacc cattttgcga cagcggatga 475801 aaaagaaaga ggctatttct taatgcagtt tgagcgcttt aaagagctga ttgctccgct 475861 gccgttaaag aatctaatgg tccactgcgc gaacagcgcc gctggactcc ggctgaaaaa 475921 aggctttttt aatgcagtca gattcggcat cggcatgtat ggccttcgcc cgtctgctga 475981 catgtcggac gagataccgt ttcagctgcg tccggcattt accctgcatt cgacactgtc 476041 acatgtcaaa ctgatcagaa aaggcgagag cgtcagctac ggagccgagt acacagcgga 476101 aaaagacaca tggatcggga cggtgcctgt aggctatgcg gacggctggc tccgaaaatt 476161 gaaagggacc gacatccttg tgaagggaaa acgcctgaaa attgccggcc gaatttgcat 476221 ggaccaattt atggtggagc tggatcagga atatccgccg ggcacaaaag tcacattaat 476281 aggccggcag ggggatgaat atatttccat ggatgagatt gcaggaaggc tcgaaaccat 476341 taactatgag gtggcctgta caataagttc ccgtgttccc cgtatgtttt tggaaaatgg 476401 gagtataatg gaagtaagaa atcctttatt gcaggtaaat ataagcaatt aacttaccta 476461 aatggagaat tcataaaaca gctttgcttg aagagtgaat aatggtatca ttatcactgg 476521 atggataaaa gagtcgtatc cgtaagtttg gtggaggtgt atgttttttg tctgaatcca 476581 gcgcaagaac cgaaatgaaa atcagcttgc ccgaaaacct agtagctgaa ttggatggtg 476641 tagcgatgcg ggagaaacga agcagaaacg aactgatatc acaagcagtg agagcgtatg 476701 tcagcgaacg aacaactcgt cacaaccgtg atttgatgag acgcggctat atggaaatgg 476761 cgaaaatcaa cctgaatatt tcttctgagg ctcactttgc ggagtgcgag gctgaaacga 476821 cagttgagcg cttagtcagc ggaggataat catttgattg tgaaacgcgg cgatgtttat 476881 tttgctgatt tatctcctgt tgttggctca gagcaaggcg gggtgcgccc ggttttagtg 476941 atccaaaatg acatcggaaa tcgcttcagc ccaactgcta ttgttgcagc cataacagca 477001 caaatacaga aagcgaaatt accaacccac gtcgaaatcg atgcaaaacg ctacggtttt 477061 gaaagagatt ccgttatttt gctggagcaa attcggacga ttgacaagca aaggttaacg 477121 gataagatta ctcatctgga tgatgaaatg atggataagg ttgatgaagc cttacaaatc 477181 agtttggcac tcattgattt ttagacatat ttgcaggttg ctcaaataga gcaacttttt 477241 ttgttttcaa aaaacataaa cgatataata gtgaaataac gaaaaaatat gttgtttttt 477301 attgggaggt aagcgaattt gatgtcgaac cagactgtat accagttcat tgccgaaaat 477361 caaaatgaac tgctccaact gtggactgac acactaaaag aattaagcga gcaagaatcc 477421 tatcagctga ctgaccaagt gtatgaaaat atatctaaag aatatatcga cattctgctg 477481 ctgtctgtta aggacgaaaa tgctgctgaa agccaaatca gcgaactggc gcttcgagcg 477541 gtccaaatcg gactgtctat gaagtttttg gctactgcac ttgccgaatt ctggaagcgt 477601 ctctacacga aaatgaatga taagagattg ccagatcaag agagcacgga attaatctgg 477661 cagattgatc gctttttcag cccgattaac acagaaattt ttaatcaata ctcaatctca 477721 tgggaaaaaa cagtatccct gcaaaaaatc gcgctgcaag agctgtctgc gccgcttatc 477781 ccggtgtttg aaaatatcac tgtgatgcct cttgtcggaa caattgatac cgaacgcgcg 477841 aaacgaatta tggaaaacct tcttaatggc gtcgtcaaac accgttccca agtcgtgctg 477901 attgacatta caggtgtccc tgtcgtcgat acgatggttg cccatcatat tattcaggca 477961 tcagaagctg taaggcttgt cggagcaaaa tgcctgctgg ccggaatccg tccggaaatt 478021 gctcaaacaa tcgtcaacct ggggattgat ttatcccaag ttataactaa gaataccctg 478081 caaaaaggaa ttcaaacagc attggaaatg acggatcgaa aaatcgtttc attgggggaa 478141 taacattttg agacatccga aaatcccgat cttgaaactg tataattgct tattagtgtc 478201 cattcagtgg gaacttgatg accagacagc attaactttt caagaagact tattaaataa 478261 aatatacgaa acaggtgcta acggagtcgt cattgacctg acatctgtgg atatgattga 478321 ttcatttatc gcgaaagtgc tgggggacgt cattacaatg tctaagttaa tgggggctaa 478381 agtcgtcttg accggcattc agcccgctgt ggcagtgacg ctgattgaac ttggaatcgc 478441 gcttgaggaa atcgaaactg cgctcgactt agagcagggg cttgagacat tgaagcggga 478501 attgggggaa tagcgaatga acgaccaatc ctgtgtaaga atcatgacag aatgggatat 478561 tgtggccgcc agacagctgg gacgaaacgt tgcgaaagaa ctgggtttcg gcacggtaga 478621 ccaggctaga attacaacgg ctatttcaga attagccagg aatatttatt tatatgccgg 478681 caaagggcag attggaattg aacaggtcgc agacagagga aaaaaaggcc tgaaaatcat 478741 agcggaagac caagggccgg gaattcctga tatccgaaaa gtcatggaag acgggttttc 478801 aacgtctgga ggacttggtg cgggacttcc cggggtcaaa aggctgatgg atgaattcag 478861 cttaaattcc gtagcggggg aaggaacaga gatacaagcc atcaaatggc ttcggtagga 478921 ggtaagaacg tggattttag ggaggttatt gagcagcggt atcatcagct gcttagtcga 478981 tatatagccg aattaacaga aacatcttta tatcaagccc aaaaattcag ccgaaaaaca 479041 atcgagcacc aaattcctcc ggaagaaatc atcagcattc acagaaaagt gctgaaggag 479101 ctgtatccaa gtctcccgga agatgtgttt cattcgctgg attttttaat agaagtcatg 479161 attggctatg gaatggctta tcaggagcat caaaccctta gagggataca gcaggaaatc 479221 aaatcagaaa ttgaaatcgc ggcaaatgtc cagcagacgc ttctcggaac taaagttcct 479281 caggaggaag cgctggatat cggcgccatc agtgttcccg ctaaacagat gagcggtgat 479341 tactaccact ttgtcaaaga caaggaatcc atcaatatcg caatcgcgga cgtgatcgga 479401 aaaggcattc cagcggcttt atgcatgtcc atgattaaat acgcaatgga ctctttgccg 479461 gaaacgggca tacacccttc tcaagtgctg aaaaatttga atcgtgttgt tgaacaaaac 479521 gttgatgcca gtatgtttat tacgatgttt tatgcgaatt acaatatgga caagcatcaa 479581 tttacatatg cttcagcggg acatgaaccg ggattctatt attctcaaaa agacaacacg 479641 ttttacgatt tagaggccaa aggactcgtt ctcggcatct cgcaggacta tgactacaaa 479701 caattcgatc agcatctgga aaagggcgat atgattgttt tattttctga cggcgtcaca 479761 gaatgcagaa cggaaaacgg tttcttggag cgtcctgatc tgcagaagct cattgaggaa 479821 catatgtgtt cctctgcgca ggaaatggtc aaaaacattt atgacagcct cctcaaattg 479881 caggattttc agcttcacga tgattttacg ttaattgttt tgcggagaaa ggtttaacgt 479941 ctgtcagacg agggtataaa gcaactagtg atttgaagga aaatttgagg tgatacgaat 480001 gaatataaat gttgatgtga agcaaaacga gaatgatata caagtaaaca ttgcaggaga 480061 aattgatgta tactcagccc cggtgcttag agagaagctc gttcctctgg cagaacaagg 480121 agctgactta agaatttgcc tgaaagatgt cagctacatg gacagtaccg gattgggcgt 480181 ttttgtaggg acctttaaaa tggtgaaaaa acaaggtggt tcgctgaaac ttgaaaatct 480241 ttctgaacgg ctgatccgac tgtttgacat tacaggcttg aaggacatca ttgatatttc 480301 tgcaaagtca gaaggtggag tgcaatgaag aataatgctg attacatcga aatgaaagtg 480361 ccggcccaac ctgaatatgt gggaattata agactgacgc tgtcaggggt cgcaagcaga 480421 atgggctata cgtacgatga aattgaagac ttgaaaatcg cagtcagtga ggcgtgcaca 480481 aatgcggttc agcacgctta caaagaagat aaaaatgggg aagtgtcaat acgattcggt 480541 gtgtttgaag accgtttaga ggttattgtg gcggatgaag gagacagctt tgactttgat 480601 caaaagcagc aggatctagg gccgtacaca ccttcgcaca cagttgatca attatcagaa 480661 ggagggctcg gtctatattt aatggaaacg ctcatggatg aagtcagagt gcaaaaccac 480721 tccggcgtca ccgtagcgat gacaaagtat ttaaatgggg agcgagttga tcatgacaca 480781 accatcaaaa actacgaaac taactaaaga tgaagtcgat cggctcataa gcgattacca 480841 aacaaagcaa gatgaacaag cgcaggaaac gcttgtgcgg gtgtatacaa atctggttga 480901 catgcttgcg aaaaaatact caaaaggcaa aagcttccac gaggatctcc gccaggtcgg 480961 catgatcggg ctgctaggcg cgattaagcg atacgatcct gttgtcggca aatcgtttga 481021 agcttttgca atcccgacaa tcatcggtga aattaaacgt ttcctcagag ataaaacatg 481081 gagcgttcat gtgccgagac gaattaaaga actcggtcca agaatcaaaa tggcggttga 481141 tcagctgacc actgaaacac aaagatcgcc gaaagtcgaa gagattgccg aattcctcga 481201 tgtttctgaa gaagaggttc ttgaaacgat ggaaatgggc aaaagctatc aagccttatc 481261 cgttgaccac agcattgaag cggattcgga cggaagcact gtcacgattc ttgatatcgt 481321 cggatcacag gaggacggat atgagcgggt caaccagcaa ttgatgctgc aaagcgtgct 481381 tcatgtcctt tcagaccgtg agaaacaaat catagacctt acgtatattc aaaacaaaag 481441 ccaaaaagaa actggggaca ttctcggtat atctcaaatg cacgtctcgc gcttgcaacg 481501 caaagctgtg aagaagctca gagaggcctt gattgaagat ccctcgatgg agttaatgta 481561 atgatccagg ttgaagaaaa cgagcatatt caaactctag tatatcaact gaataaagaa 481621 gggaaatcga tttgcggtga cagttttttt atgaaagctg atgataagga gttaatttgc 481681 gcggttgctg acggactggg aagtggatca cttgctaacg aatcctctgc agccatcaaa 481741 gacttagtgg aaaactatgc gagtgaagac gtagaaagca ttatcgaacg ctgtaatcag 481801 gcgatgaaaa acaaaagagg cgctacagca tctatcctga aaatcaattt tgagcaaagg 481861 cagtttacgt actgctctgt cggaaatgta cggtttattc tgcattcccc gtctggtgaa 481921 agcttttatc ctctgccgat ttcgggctat ttatcaggca agccgcaaaa atacaaaacg 481981 cacaccgcca cctatgaaaa gggttcaaag ttcattatac atacagatgg actcaacgta 482041 cctgatatcc gctcccattt gaaaaaaggc caatcggtag aagaaatatc gaattcgctg 482101 aaaatgtata cgacatcgag aaaagatgac ctgacctata ttctcggaca gctgtcctaa 482161 aaaaccagaa aaagaagctg gacatccggc ttcttttttt tgcggttgac tattaataag 482221 tgcgcttatt atacttaata agtgaactta tcattctggg agcttatggg atgtggaatt 482281 atgaatacac agcgatagct gatgtggatg tgggaaaacc tggaactgtt atcaggaaac 482341 agaaacaatg gatcaatggg agacgggtat tgcatcagat tctttgaaag gacaatttca 482401 aaatggaacg gaaggaacat tgcttctgca aggaaaaaca attctcttat ggcttgagca 482461 tgtggagaaa catcgggcgt tttctgtcat ggtcaacatg cccgcatagc aatgtaataa 482521 tggagttttt tcacgtgctt caaaagcaaa aagaagattt gtgtatcaca tatggaattg 482581 tattagaagg cgctgaagca aaaaagtggg gagaaatcat tgggactgaa ctgtctaaag 482641 acatgccgac ggctgtcagc aggcttgtcc atctttacgg aggagtgata aaatgaacac 482701 aaattactgg atcggcgttg tgtcagagca acatgtatta aaaggcgctg ccggcggttt 482761 tgcacagctg tgccatggaa aaaaagcccc gctcgccaaa atgaaagagg gagattggct 482821 gatttattat tctccgagag acgcatatcc agacggcaaa ctgctgcgaa gctttactgc 482881 gatcggcaaa gtaaaaagcg gaaacatcta tccgtatcaa atggctccga attttattcc 482941 ataccgatta gatatagact attatccatg ccataaaatc ggtttttacg acattaaatc 483001 aaagcttgaa tttgttcagg aaaccaagca tcttggcttt ttatttcgca gaggacactt 483061 tgaaataagc aaaaaagatt ttttgacaat agcacaagcg atgggagtta acataagtgg 483121 aatggcactc taaatttagc ggtccgaaca caagcccggg ctttttatta tggcaggcca 483181 cgcaaagttg gcagcggaaa gtaggaaaag cattggctga gtttgacctg acccacgttc 483241 aatttgttct gctgacctcg tgcaagtata tgattgctca cggagaaacc gtcacgcaaa 483301 aaaaacttgc aagcttcagc cagaccaata tcatgatggt ttcggaggtt gtgcggacgc 483361 ttgagaaaaa aggatttatc gaaagaagca aaaatcccca ggataaaaga gaggtcctcc 483421 tgtctcttac agaaatagga ggagaaaaag taacagcggc tttgccaatt gttgagaaga 483481 ttgatcaagc cttctttgca gctgcgatga aaaaagagaa ttttctgagc ggcttacagg 483541 aactattgaa acatgagtaa agatacgggc agcgccagct gtcttttttt atgtgttttt 483601 ttcggttttt gatacactag agaaagaacg acaaaattgg aggctttggt tacatggaaa 483661 cgtcagccct tttaaaacag caaattgcga aagaaatagg tttatcacaa aaacacgttg 483721 aaagtgtcat ccgcctgctt gaggacggca atacagtccc gtttattgcc cggtatcgaa 483781 aagagcagac gggttcaatg gatgaggttc agattcagac gatttctgaa cgctggcaat 483841 acatacaaaa cctgaatcag cgaaaagaag aagtcatcag gctgattgca gagcaggata 483901 aactgacaga taatctaaaa cgtaaaatcg agcaatcggt gaagcttcag gaagtggaag 483961 acctttaccg cccttataaa caaaaacgta aaacaaaggc gacagtcgcc aaaagcaaag 484021 gccttgagcc gcttgccgac tatatcctga cacttcccca agatgatcat ctggcagcaa 484081 ctgcagacca atacatcagc gaagaaaaag aagtgttcac acgagaagaa gcgattgaag 484141 gcgccaagca cattattgcg gaacaaatct cagacgagcc gaccttcaga aagtggattc 484201 gccaggaaac cttcaaaaga ggaaccatta agtctgcagc cggaaagtcg gcagacaccg 484261 atgagaaaaa tgtgtatgaa atgtattacg agtatgaaga gccaattgca aaagttgttc 484321 cgcatagggt gctggcaatg aaccgcggcg aaaaagaaga cattttaaag gtagcgatcg 484381 aaccgcctgc ggatcacatt aaggcgtatt tagaaaaaca aatcatcaaa aatcgctcaa 484441 catccgtaag agagattttg caggagacaa ttgaagacag ctataaaagg ctgatccagc 484501 cggcaatcga gcgtgaaatc aggaaagagc tctcagaaaa agctgatgaa caggcgattc 484561 atattttctc agagaacttg agaaagcttc ttttgcagcc gccgatgaaa ggcaaaaccg 484621 ttctcggtgt tgacccagcc tttcgaactg gctgtaagct cgctgtgtca gatgagaccg 484681 gaaaagtctt gaaaattgat gtgatctatc cgcatgcgcc agtcaacaaa acaaaagaag 484741 cccatgaaaa agtgaaaaag attcttgagc agtatcaagt cgagatggtg gcgatcggaa 484801 acggcacagc atccagagaa acagagcaat tcatcgtcaa tgtactcaga gacatgccgc 484861 gcaaaattta ttatgtgatc gtcaatgaag cgggagcaag cgtctattcg gcttcagagc 484921 ttgccagaga agaattccct gaccttaagg ttgaagagcg cagtgccgta tctattgctc 484981 ggagacttca agacccgctc gcggagctcg ttaagatcga tccgaagtct gttggtgtcg 485041 gacagtatca gcatgacgtc agccaaaaac gcttaaatga atctctgcgg tttgtcgtcg 485101 aaactgtcgt aaaccaggtt ggagtaaacg tcaacacagc ctccgccgcg ctgcttcaat 485161 atgtagctgg attatcgaag tctgtagcag gcaacgttgt caaaaaacgt gaggaaatcg 485221 gaaagttttc aaatcgaaaa gaactgaagg acatcccaag gttaggtgcg aaaacctatg 485281 agcaatgtat cggtttctta agagtgcagg aagggacaga gcctttggat agaacaggca 485341 tccacccgga aagctataaa gaaacaaaag cacttttgaa aaaactcgga ctttcaacag 485401 aacatatcgg cacggcggaa ttgaaggaca aaatcaatca gctggcgctc tctgaaacgg 485461 caaaagagct gggaatcggc gaaatcactc tgaaagacat ttgtgaacag ctgacaaggc 485521 cggaacgcga tccacgcgat aaggtgccta agcctttgct gaaaacagac gtccttcagc 485581 tggaagattt gaaagaggga atggaactgc agggcaccgt gcgcaatgta gtggacttcg 485641 gagcgtttgt tgatatcgga gtcaaacaag acgggcttgt gcatatctca aaattgagca 485701 atcaattcgt caagcatcct cttgatgtcg tatctgtcgg cgatattgtg acagtttggg 485761 ttgacggcgt agatgtacaa aaaggcagag tatcgctgtc tatggtaaaa taaaagcact 485821 gcttacgagc agtgtttttt cctatagaaa taccagcatt gattcagcag tttaatttgg 485881 taattatctt tttcaaggaa cgctttttgc atctgctttt taagccaatt tggcataggc 485941 tcattcctcc tcagctttta tcataagagg gacagtgatt accatattgt atgcgaacgg 486001 tgaattgtcc cgttcaatgt tttttaagtg aggtgcacca tggataacaa agagcttcaa 486061 aagctgacag aggatatttc tgaaacatat tttaaaaagc cgttccgcca tcaggcgctt 486121 tttaatgacc ggcttaaaac cactggcggc aggtacctgt taacctccca taacattgaa 486181 ttgaacagaa aatatttgat tgaacacggc agggaggaac tgattggcat catcaagcac 486241 gagctctgcc attatcatct tcatcttgaa ggaaaagggt acaagcacag agacagagat 486301 tttagaatgc tattgcagca ggtcaacgcg ccgaggttct gtacacccct taagaaaaaa 486361 gcggaaaaca aaaaaactta tatgtatatc tgtacgacct gcggccaaca gtatataaag 486421 aagcgcgcca tgaaccctga cagatacaga tgcggaaaat gccgcggaaa aataaaaaga 486481 attttttcgt gaaaaaggtt gacgaatatg gcaagcctat gttacattat aaaagtcgtc 486541 acgagagata aataaaaaca tttacctctt gacactgcaa atcaaggctg atataataag 486601 tcttgtctca ttattccaca gtagctcagt ggtagagcta tcggctgtta accgatcggt 486661 cgcaggttcg aatcctgcct gtggagccat attggagaag tactcaagtg gctgaagagg 486721 cgcccctgct aagggtgtag gtcgcgtaag cggcgcgagg gttcaaatcc ctccttctcc 486781 gccataagat ttcgatataa gttctcaacc atcggcccgt tggtcaagcg gttaagacac 486841 cgccctttca cggcggtaac acgggttcga atcccgtacg ggtcattcca tttcgttggg 486901 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 486961 tagcccagcc atttttattt ttgaaatcta atagtaagag ccattagctc agttggtaga 487021 gcatctgact tttaatcaga gggtcgaagg ttcgagtcct tcatggctca ccatttgtct 487081 ttttgcgggt gtggcggaat tggcagacgc gctagactta ggatctagtg tcttacgacg 487141 tgggggttcg agtcccttca cccgcacttt atttacaaag tgcacgcaaa tctgttttac 487201 taggttaaga gcctactaaa ccagcacaac acaatttaat gatcacgcgg tcgtggcgga 487261 atggcagacg cgctaggttg agggcctagt gggtgaataa cccgtggagg ttcaagtcct 487321 ctcggccgca tctcaataat accaagggtt taaccacctt tggtattatt tttttgtgtg 487381 gaaaatacgg ctatgggaga agacttgctc accaaaactc accagttact taaagtaagt 487441 catccaaacg gtcggcggtt ccttctgttt attaggaaaa agatatccgt tcattgtaaa 487501 agaaacgaac catgtcctat tcgttcaaaa aaactaaagg gtgatacata ttatacatga 487561 ttaatatgta tcaccctttt ctttcttgtt caacaatcgc gcttgaggag aacataagct 487621 aatacaactg actcgatttc taaagttgct ccattctttt tttaaacaac tcatccacaa 487681 cctgttttaa aatctcgtac gactgaattt ccttgctcaa ttcgtaaata ttagataaca 487741 caattaattc atctgcgtga tacatttgtt ggaaatcaat tagttcgcga cgaattgttt 487801 ctcgatcacc catgattgta taccccagtc gactgtggag aatttctaat tcaaactgtg 487861 ataacgattc taggaagttt tcagtgggtg gaataagctt acttaaatta tttgtataaa 487921 tatcaatata cacctgcaaa tgacttgcag aaataaaaga tgcctcgtct atagattctg 487981 ctgcaatcac attaatgcaa gcgatcacat aaggttcttg taaataagaa gacggttgga 488041 aattttctcg ataaatagag agcgcttctt ccatcgaatg gggtgaaaat tgagcgccaa 488101 atgcataggg taaaccaagc tttgcagcaa tttccgctga atccgttgag gatcctaaca 488161 caaaaacagg cacatgcgtt ccaatacccg gataagcgcg aacctcaccc tgtacactct 488221 tatccccgac aaaacgcaaa atatcattta cttctctttc aaagaaaaac actccattat 488281 ggttggaacg acgaatcaca tcggccgttt tttgatccgt tccgggtgcg cgtcctaatg 488341 ccaaatctac acgatttgga tataatgttt caagtgttcc aaattgctcc gctacgatta 488401 atggggaatg atttggcaac ataatacccc ctgaacctac gcgaatgtct tttgtatttg 488461 ctaatatatg ttgtacaatt gatacggttg ctgcacttgc ataagcgtcg tgattatgat 488521 gctctgcaaa ccaaatccgt ttatagccca tattatctac agctttagct aatgacactg 488581 cagaatcaat cccttgtttc attgtttctc cttgtcttaa tggagcaact gataaaacag 488641 atatatcaaa ttttttcata atttcacctc taaaataatg aacttataca agatcaatgg 488701 aaaaaacatt ttgaaaaatt gtttcatatt aaatggtgtc cattcctctt tgatttgcat 488761 gcaaataaat atatactttc tcaaacgatc aatacatagg caaaataaag ttatttcaca 488821 atttcacttt acttttaaag ttttaagcaa acataaaaaa atgttcagtg aacaaaatat 488881 gtaaaataca tcttattttt cagaaaggat acaagaaaat gattgatgaa atagataaaa 488941 aaatacttga tgagctgtct aaaaatagtc gccttacaat gaaaaaatta ggggaaaaag 489001 tacatctcac tgcaccagca accgcatcaa gagtagtaaa gttaatagac aatggcataa 489061 taaaaggatg tagtatcgaa gtgaatcaag tgaaattagg cttctctata catgcttttc 489121 ttaatattta tatcgaaaaa atccatcatc aaccctattt agcttttata gaaacacaag 489181 ataactatgt aataaacaat tataaagtta gtggagacgg ttgctatttg cttgaatgta 489241 aatttccttc aaacgaggta ttagatcaat ttttaaatga cttaaataaa catgcaaact 489301 ataaagtgtc gattgttatt ggtaaatagt taactttata aaacggagat gtgcggtcat 489361 ataacatgat atatatgctc taaaaaagcc ctaggttgga tatggaattt accaagctgg 489421 ggccttttta tacattataa taacaagcgc attattcatc agacattaat gaagtattat 489481 aatgcttttt tacttcctta atagacaaat aaagctgata gtttccatac ttcaataaat 489541 cattcagaag gtgatttaaa acttcttgtg aatgaaccgt taccttcaga agataacatg 489601 catctcccga aacacgatga gcttcgctaa tttcattacg agtagcaata aatttcaata 489661 aatcatcatg catatatgca ttcatgaaaa agaagacaaa ggctgtaaaa gaaaacccca 489721 tcttcaattc atcaaccaca atcgaatatg ctttaatgat accgttatcc tccatttttt 489781 tgatgcgatt gcctaccgct tgtcctgtca tatgaatttt ttcaccgatt tctttccatt 489841 gtatccgagc atttttattt aataattgga gaatttgaaa atcaattgaa tcaatttgca 489901 tagtaactcc tttcacagtg aaaaagtttt acaaaatagt atttcatgag accatcgaaa 489961 attcaatgga aattatatat ccttatacag tataaaaatt ttaagaggtg aaaaaatgac 490021 aacagcttta ttagtgattg atattcaaaa tgattacttt ccaaatggga agatggcttt 490081 aacaaaccca gagaaagcag cacaaaatgc ggctaaacta ctttcacact ttagaaacac 490141 aggcgcacct gtctttcatg tacagcatat cacagaaggt aacatcgctc attttttcca 490201 tccaaataca gaaggtgtcg aaattcatga gtcagtacgt ccattagaga aagagacagt 490261 cattgtaaaa catatgccga atagcttttt caatacagat ttaaatggaa agctacaaga 490321 agaaggggtt aaagaattag ttgtttgcgg tatgatgtcc catatgtgta ttgatgcaac 490381 agttcgttct gcagttgaac atggttatgt atgccaagtg gtagaagatg cttgcgcaac 490441 aacaacattg caaattgaag ataaaatcgt tcctgctgag catgtccatt acgcatttat 490501 ggccgcatta aatggtgtct atgcaacagt aaaaaccaca gaggcatttt taaaataaaa 490561 gaatttcctg cgcgaacata acgtctttct tttcacaaga aagatgattc aacaacttaa 490621 aaaaggatgt tcagaaaaat acttctggac atcctttatt cattatcttt tattgttttt 490681 cagtatcatt attcccatct gataaaagat caagatgtcc tgtttttgat ccatagtaag 490741 accatataca gggattgttt ttgccataaa tatagatatt gatgaaggtt tacataaagc 490801 acctaattgc ttgatttact ttaatgttag atccctcaat aactccattc tcttctaatt 490861 tctctactct agctgtagct gctgggcatg ttaaatgtac tctctcccag atctttcatt 490921 gaattcggct attatacata atttctctat aattttttat ctgtttgatc tatttgaacg 490981 ttaattcctt tcgaaaataa agtcaaagag ttaaaacact tttttttatc tatgtattcg 491041 aacactgctg atattataca cttaactctg tcgatctaag acaaataaaa aaagaaagtg 491101 agttgtaaat atgaatatta cacaaattcg aaatgcaaca attgttgtaa aatacgcaaa 491161 taaaaaattt ttgatagatc ctatgttagc agagaaaggt acgtacgcta ctttccctga 491221 aacgatcaga caagatttat ttaatccttt ggtgagtttg ccaacatcaa ttgataacat 491281 tctggatggc gtagatgcgg taattgttac tcatctacac ctagatcact ttgatgatgt 491341 ggcaaaaaac gtattgccaa aaaacatcaa aatgtttgtt caaaatgaag cagatgcaaa 491401 agaagtaaaa gcaagtggtt tcaaaaatgt agaagtgcta catcaagaca ctgtttttga 491461 agggatccaa ttagtaaaaa caaaaggtga acatggcaga ggggaagagt tattaaactt 491521 aatgggtgat gtttgtggat tagtattcaa gcacccaagt gaaaaagttt tatatgtagc 491581 tggggataca gtttggtatg atgctatcga agacgagatt catacacatc aaccagaaat 491641 cattgtggtt aatggtggag acaatcaaag attagattta ggttcactca tcatgggaaa 491701 agaagacatc tatgaagttc acaaggctgc tcctcatgct aagattatat ctgttcatat 491761 ggaagctgtt aaccattgga cactatctag agaagaatta aaaaacttta gtaaagaaaa 491821 aggattctca agtaatattt tagtgccaga agatggcgag tcttacacat tttaatatga 491881 acaccgacaa ataaatagaa gaagctcata attataaaaa ctaatcatga gcttcttcta 491941 ataatgaata ttttaaattt taaatatatc gaaaatccta aatatacgga ataacaaaaa 492001 tggaatgttc caatgatgac aaaaaaactt gaaaagcaac aaagatgtgt cgttaggagg 492061 tagaattcat ggtaatgaca aaaaaagata caaatatatc aacacagcag cctctttggt 492121 tacaaggtta tattgattca ccagaaaaac aaaaccaact ttataaaaaa acattaaaaa 492181 tcttgatttt ttcacaaata tttgggggag caggacttgg agctgggata acagttgggg 492241 cgcttcttgc acaagatatg ataggatcgg aaaatgtagc aggaattcca actgccctct 492301 ttacttttgg atctgccgta gctgccctgc ttataggagc atcctcacaa cgttttggtc 492361 gcagagctgg acttgcaggt ggtttcctta taggcggatt aggtgctata ggtgtgataa 492421 tcgcggcttt aattaacagc gttgccctat tatttgtttc tcttcttatt tatggagcag 492481 gtatggcttc taatcttcaa gttcggtatg ctgggacaga ccttgcaaat gagaaacaac 492541 gggcaactgc tgcaagtatg gccttagttt ctactacttt aggagctgta gtaggtccta 492601 acttagttaa tacaatgggg gaatttgcag attcaattgg tgttcccaat ttagctggtc 492661 cgtttattat gtcaggagca gcttttataa ttgctggaat tattctctta atttttcttc 492721 gtccagatcc gctgtttgta tcaacagcta ttgcgaatgc tgagaaaaaa gacgataaag 492781 tacaaatagg aggaagtcta aaaaatcctg ctatagacaa aaaaggaata atggtaggag 492841 ctgtcattat gattttagct caactaatca tgacagctat tatgacaatg acaccggttc 492901 acatgggtca tcacggtcat ggtttaagcg aagtgggatt agttatagga ctccatattg 492961 cagcgatgta tcttccttca ccattgactg gtttattagt agataagttt ggtcgcacaa 493021 ctatggctat tgcttcaggt gccacacttc ttgccgctgg gttggtggca gctattgcac 493081 cggcagactc attatcattg ctaatcctag cactagtatt actaggggta ggttggaact 493141 ttggtttact aacgggaact gcccttatta tagattcaac acatccatct ctacgtgcaa 493201 aaacacaggg aacattcgat gttttattag cactatcagg agcagcaggt ggagccttgt 493261 caggaatggt tgttgcacat tctagttata caatactatc aatttctgga gccgttttat 493321 cattgttact cattccagta gttatttggt attttagaag gattcaggaa aaagcataag 493381 cttatataac tgtctttgaa gaacctaagt agacattact ttaccggaac ctcctttttc 493441 tatttattat agtaaggagt tgacatggca ttagtggcat gtgtataact acacaattat 493501 ttgggattca gagagcatgt aatgaacgga agagataatt atttatcact tttattattg 493561 tacggtgttc ttgtggcatt aagttcagtc aattttggtc taactgtttt ctttttgttt 493621 tcatcacctc tccatattat taacaaacac gaaaaggatt ttaatgaaaa taaaatgatt 493681 agcgtatgta tctctaattt tcaaaatgaa tgaatagtcc tttttaagat ttacacactt 493741 attctccaag gaaaaatgac tcaatttttc gattttttat gtaaatcaaa aaagaatcat 493801 gttagagtag gtgtgctgaa aataattcaa aaaattattt tgcgatatga ttaaagtaat 493861 attgccagag agtttcaatt ggacaaaatt gtaagtgttt aatacactgg ggctgcaatc 493921 aaatatgcac ctggaatcaa ttgctaaacg ggggagttta tatgaacaac aagaaaaata 493981 tctttgatat tgttatgtac attattttcg gtgtgttaag tctttttcta gttgcaaaaa 494041 ctgattatgg cactggagtt ttagtgtttg ttgcaatttt atacctcgct gttattgctt 494101 ataaaattaa gcaagtattt agtaattcag attcttaagg tgtaacacaa ggaggatttc 494161 aattgagaaa gaaaagagtt attacttgtg ttatggctgc atcattgact ttaggctcac 494221 ttttacctgc aggttacgct tctgcaaagg aggactctaa gacaacccct tcttacgaag 494281 aactagctct acattacaaa atgaaaagtg aaaagatttc atcgaacggg aaattagttg 494341 aaattgagta tgtgagtgga aatgaaactc acaaagttca gatgaacgga aataatcata 494401 ctgtaaaagt cgatggcata gaacaaaaag gtttaaactt tgagtatgat gaaaatgttg 494461 ctaaaagaac aaattatgaa aacaataatt tgaaatcaaa tgaattcaca acacaggctg 494521 caaaacctaa aaagggatac cattatgtgg ggactttatc tgggcataca aaagcagcta 494581 aaaatgcgtt atcagttaca atgtcattag tcggtattgt ccctggcttg ggatggggga 494641 gtaaggctgc cactatttta ttctcttatt gggcaaaaga acaaatccct gatgcgtatt 494701 ataaatatga tttatacgaa aaaggagcaa tgactgatag ttggtatcag tatgctacag 494761 ttcaattttt tgaagataaa gctcataaaa agaaaatggg caaaccttgg acaagtactc 494821 ctgcaaaagt agatttacct aatagctaat tttaaaatca ctttgtcttt ataaaggaca 494881 aagtgatttt ttgttataca gaagtaaaat ccctcgtctg aggaatcttg gaaaaaactt 494941 ggttcaattt tgatataaca tgtttttttc ttgctaattt agtttttcta tgtatcgcta 495001 cacattctaa ataataagat attagccgga cggttgatgc caagctcaaa agtttatatg 495061 gaagtcaaag cataaaaaag ggtgttacaa cgtgtagtct tctttttatt ttgccaacgt 495121 aacaagtgtg aaagtaatga tttgtaggat cagttaagaa aggtttaaga ttagatattg 495181 aaaaatttta tatattttca ataaaatact ggtactataa taaatgtata cagattgtat 495241 ggagatgtaa ttaattaaaa aggagttttt taattgcgtt ggagtaaatg gttcaatgtt 495301 ttttgtatag tagcattggg atcaatatat ggttataaat tatttactaa ccaagaagtc 495361 agtactactc gtttaataat agcttctgta attgtgttgt ggaatattgt tggacttttt 495421 agcaaagaat cagtaaaaca agcacagcaa gcaaattaaa agtcataaag ttgggaaaga 495481 aggatgttac ttatgtagta tccttcttta ttattccttg aaaaatgaaa caaattggag 495541 attacagctt atataatcaa ttgaagtcgt tgattatttt catgaacagg agatttaatg 495601 ctttctgatg aaatattatc gtatgaatgt tgcaagagga aacgttactc aaagattaca 495661 gggatgtgat gaacactcct ctttatcgca ctcacctgac cccaaattgt tggggaaggg 495721 caggtacgga agatagagta ttttttcttc gtaacaaatc gaaaaggttg gataataaaa 495781 aacttataat ctaaggcggt atatagttgt gaaaaaggcg ttatttctta tattagacca 495841 gtatgcagat tgggaaggtg tttacttagc atctgcatta aatcaaagag aagattggtc 495901 ggttcacact gtttctttag accctattgt aagctcaata ggtggtttta aaacatctgt 495961 cgattacata atagggttag aacctgcaaa ttttaatttg ctagttatga ttggcgggga 496021 ttcctggagt aatgacaata aaaaactatt acattttgta aaaactgcat ttcaaaaaaa 496081 cattccaata gcagcgatat gcggtgcagt ggattttttg gcgaagaatg gtttgctgaa 496141 taatcatagc catacaggta attttgttta cttatggaaa gattacaaac aatataaacc 496201 gattagcagt tttgtagaga aacaagcagt aagagataaa aatttggtta ctgctaatgg 496261 aactgcccct attgaattta ctaatttaat tttagagatg attgattttg atactcctga 496321 gaacatagag aaaatgatgt atatgaatcg ttatggtttt tatcattttt gtgataaata 496381 tggaaatcca tttgttgatt aatttgctgg aaatgatttt cccgaatagg gggctttgcg 496441 attgagttga atttcctaat aaagcaaaga aagatgattt gaggtcaagt ttaacaaata 496501 atgccatcaa tattaatttg cagttatttc cgattcctga tataataaag aagaattatt 496561 tttgttcggt gtaaaggata gtatgaagat tgacttttcg tcttgatgat actttgggca 496621 aggatagtat atactgtgtg gttacacact aggaggcaac aaaaatggaa caaggtacag 496681 ttaaatggtt taatgcagaa aaaggttttg gctttatcga acgcgaaaat ggagacgatg 496741 tattcgtaca cttttctgca atccaaagtg acggattcaa atctttagac gaaggtcaaa 496801 aagtatcgtt tgacgttgag caaggtgctc gtggagctca agctgctaac gttcaaaaag 496861 cttaatcttc aatcgtttat acaaacaggc tctttatata gggcctgttt ttttatgtct 496921 atatcatact caataaaaaa ccctactcaa cgttcgagta gggagatgct acaaggtaat 496981 agaaaaagat ttaaaacttc aaaggtttgt ttacagtata acatactgga ttgacaatat 497041 gcggaatgta tataaattat ttaatgtttt gttcaaatat agataactga ctcttttttt 497101 cactaacctg ttcgttcatt taagtaagat tagatgaatt ataaaaatgg tttcatctaa 497161 atgttatcaa ctcgcatatc tcttttatga gaagaagata aacaattatt attcaatgtt 497221 gcagtggata taagaaattc ttaaaaataa tgaggagatc gattgttttt ttctcctgga 497281 aataatcact tagagatacc taaaacaatg aaagccctac ctctcttcca tccttacggc 497341 tccttgtccg tgccagtgtg aatcaggata ctaaaaaaag tgactatttt attgagtttt 497401 ttggtaaaac ttcaatcttc gcagaagaaa tgtaaataat aaaaatggat tagaatgtag 497461 gaataacaaa agaggtcgtt aatgttctaa acataagttg gagaagattt gcttttcatc 497521 ataatattcc gaaatatctt ttgggatgta tctaaccaaa actttttatt tgtttttcag 497581 tgattccttt aattacttcc agttcactaa tcaaaaattc atatgcatta tccagcattt 497641 ttttttcgct tgcattaagt gctttttctt tcttcatacg cattaaatca cgtacaactt 497701 cagcaccttc ttgtatttca cctgttttta ttttgtccgt gtttattttg tacctttgct 497761 tccatggcag taacctatcg gattctccat gctgaaaaat gtgcataatg tgttttaatg 497821 caagtatatc ggtaactggt cgtatattcg aactcaatat tttactcgtt ggaatcataa 497881 ctgtcatatt actgattgac attcttatga cataatactg ttgtttttcc tctaagaatt 497941 ctttttcttc tatggcttca attatacctg ctccgtgcat tggataaaca atgttatcgc 498001 caatttgaaa catatcatcc acctccatat atggtatcct tcttaagatt accatatatg 498061 gaggtgtaat atcaaaattt taataataac atgatcgaat ttttgatgtc aataactttt 498121 ttgaaaaaac agatcaagca aaaacaatag ggaacgtgtc ggatttccaa tcaggaaaag 498181 gtcaattgat ccgtgtgagc agtttttcat tggctcaatg acattacaga aatgatttga 498241 gtagataaga aagaacgata ttcgtgaaat gtcagctaaa aatatttaaa gcacatgatt 498301 aagttctaat ttctttaccg atttgatatg gataacggcc gacttactta atgatgcatt 498361 ttcacttatc ttgcaagcag aaaaaggttt gttgataaac atttagccac caaattggca 498421 ttattatcag ggaaattgac aaccttcaaa tgggtattga ggcgagaaga aaaataaaga 498481 aaggagagat tataaatgaa gaccagaaca taaagaagta aaggggaaag aacaaggtta 498541 attgaaaagc aaactatata aaatagtttg cttttttttg ttatgacttc acttcttttt 498601 ctttctcttt aatgactaat aaaacaccgc tcagaattaa aaacgaacct atccaaaatg 498661 tcccgcctat ttgttctcca agcagaatcc atccgagtaa ggttccaacc agaggctgaa 498721 aaaagaaaaa gaggcctcca cttgaggcat ttaataattg taagccgtgg ttccacaata 498781 aaaatgcaca agctgttgaa acaattccca aatacaaaag gccacctaga attttagggt 498841 caagcagtag tggcgtaaaa atcgtgctag gggagtacca ttaacaggga ctccatttat 498901 taatagaata aactttatga attcattttt ttgtatgata atggcgtcat attcatcgct 498961 tgttgaaatt tacttatgaa ataactggta ctgttaaatc caacttgata agacacttct 499021 gtcacattgg attcagggtg ttgcagtaat aataagcttt tttgaattct ataatccatt 499081 acataacgta atggcgtctt attcagcatt cgtttaaaat aacggcagca ttcagaacgg 499141 ctcagttggc cagcttttgc aatgtcctct aatgtgattt tttcaacata atggagatgg 499201 atccagttta acatttgttt cattcgatga ctttttatca tttcagattg atcgtactct 499261 aattgaaaac cattaacgac caggtttttc cacattaacg ttaattgcat cgtaatgtca 499321 atctcataga gcgatgtctt ttgttgaatc aattgattta tttttttaac agcatctaga 499381 atattttttg cccactgttg atttccagcc aaaaataaat agggcaaatt ggttgaaaac 499441 atatagggct gaacatagct tgaatacagt tcctgagata aaacgaaatg gggtgacaca 499501 ttcaagcaaa tatacgtaca atccgagcct tccttttctt cggccatgtg caggtagccg 499561 ctattgataa ataatccatc cccttcgtga acctctattt tttcttcatt tatttgaaag 499621 agagctatcc cttttagtat caaaacaaat tggatttcat catgccaatg aagcggaata 499681 tagccattta tattttgatt gatcgttgtc ttgtagcagg caactggcaa ttctaccgtt 499741 cggtgctctg ttaattcttt taaattttga tcgatcacaa aattcttcat tctgacttca 499801 cacctcaata tatttatatt ttttcattca atttgagtat tttttatcat gttttgcatt 499861 tattataaca ctattattat atttattagt gaggagtcat gtatgaatac ttccaataga 499921 agaatgggat tgttctatgt tatcacaggg gcgacatgtt gggggattgg aggcacagta 499981 gccaaaaaac tttttcaaga atatcaaatt gatgtcaatt ggcttgtaac gacacgcttg 500041 cttacggctg gaatgttact tttaatgctg caactgttca gaaaggatcg ttcccaggtt 500101 attgaggtgt ggaaacacaa agcgtcggct ggccagcttc taatttttgg cctattggga 500161 atgctagctg tgcagtacac atatatggca tccattcaac atgggaatgc tgccgttgct 500221 acgttattgc aatatttatc cccagtaatc gtcattatct acacgctgtt gcgaaaacaa 500281 acggttctta ccaaacaaga tatcataact gttgtacttg ctttagtggg ttgctttttt 500341 ttgttaacaa atggttcaat gtctcaactt tcagtgccgg cagctgcagt agtatgggga 500401 gttttatcag gattcgcggc agctttttat actttgtatg ccgttggttt attaaataaa 500461 tttgattctc ttgtcgttgt aggttgggct atgattattg gcggttttgc attgggtttt 500521 atccatccgc catggcaact ggattttcaa cgattaactg ctgaggcgta tgcatatatc 500581 ttattcgtga tattatttgg aacaatgatt gcgttctggt tcttcataaa aagcttggaa 500641 agcctctctc caaaagaaac aagcctacta ggcagtctag agcctctatc agctgttgta 500701 acaactgtcg tttggttaaa agcgccattt ggttcttttc aatggattgg tgctatttgt 500761 attataggga taactttaat attggcttta cataaagagc cttctatgga gagtgaaaaa 500821 tcgatattaa agattaggaa tcatgcaaat cgggatatat aggggctttt tttgcttaca 500881 tgaccggtcc ggcaatgaaa aacactggtg gagtttgagc cctctcggca gtatcaaaaa 500941 taccaagggt tttgacgccc taggtatttt ttcttcaaga accttcaatt tttcttctct 501001 gattgaaaaa cgtattactt ttttgtgatt ggtatccaaa tttcactttt aaaagatggt 501061 gatgttacat ccttatgctc gttccacaat atttctggac cttctatttg ttcgtaattt 501121 gacgatggaa accattcgga ataaatgcgt ccccatactt cttgcagtgt atccggaaat 501181 ggcccgattg attcgaatac agcccatgtt gaggcaggaa cttcaagccg tgagaagtta 501241 tctggacacc gtttcgttgt ggctgcgcca atatagtgat cgagctctcc gttttcctct 501301 gtccgacctt cagaaaaatt cgtggatgca ctaatgaggc ctgatggtgc tacattagat 501361 agctctttta gtttatttat tgctttttca tctaaacttt cccacataga tgcaatttcc 501421 ggattaattc ctttgaaaat aataggaact ctttttttaa tgccaacgat gcgaaatgcc 501481 tctttttctt caatacggta gttcatttca tttcctcctt taattgttag ctggaaggtc 501541 attcgtggat aagctttaag ggaatggcca ttaaatctgg cttttgatgg gtttatgcca 501601 tgtaaatttt ggaatgcccg tgcaaaagaa tctggtgagt tataaccgta ctttattgca 501661 atatcaatca cttttacatt gctgtctttc agttcaaaag ctgcaagagt aagacgtctg 501721 cgacgaatat attccgataa tgaaatacct gcaaggaagg aaaacatcct tttaaaatga 501781 tattcagagc agaaagcaag ctttgctgcc tcttgaaaat caatatcatt agtgaggttt 501841 tcttcaatat actttaacgc cctattcata cttttaagca aatccattta tttggcctcc 501901 tttaaccaaa gaataacagg agtgaaatgt atttatccga cattctgtgc acagttttgc 501961 aggatgactt atatgaaata aagtaagtga ttcacttgta tttgtacagg ttttattgaa 502021 gcatgctgtt cataaaaagg catcaataaa agaaagttat aattgtctta taaacggcac 502081 attcatataa ttgagtgaaa aaggatgcgt atcatgccta tcaattcttt tgaaaattat 502141 ccgatgagct ggaagccatc gattgataaa gctgaaaagc ctatttataa agcacttgca 502201 gggcaattgg aacaggatat tttaaacgga gttttattac ctggaacaaa acttcctcca 502261 cagcgagaat tggccgatta tctagattta aatgtgagta cgatttcaaa agcatttaaa 502321 gtgtgtgagt taaaagggct gctgagtgcg actgtaggga gcggcacatt tgtatcgtat 502381 gatgcgttgt cgaatgcgta tttacttgag gatactaagc cgacacattt aattgaaatg 502441 ggagcaatac ttccagatca cgcttcatat gagcccttgt tataccaact gaaaaacatg 502501 gttcatgagg aggattatga aaaatggttt agctatggcc gggcaggtga aagcctttgg 502561 caaaaagatg cagctgtaaa gctcatccaa agaggcggat ttgaaacatc cgttgatcac 502621 attttatttg caaatggagg gcaaaatgcg attgcagcga cattggcgag tctttgtaag 502681 cctggagatc gcatcggagt tgaccatcat acgtaccctg gattaaaaac tgttgcatca 502741 ttgcttagtg tgcaaatcgt accgataaaa tcagaaaacg atgaaatgag tccggagtca 502801 cttgaatatg cgtgtaaaaa cgaaaatatt aaaggtttgt atttaatccc ggattatcat 502861 aatccgacga cttcctttat gtctgttgag aatcgaagaa tggttgcaga cattgtaaag 502921 aaatataatc tgtttgttat tgaggatgca tcgtaccatc ttctcaacaa aaatccgctt 502981 ccggcactcg cctcattcgc accgcaacag gttattcata ttgcaagttt atcaaaatcg 503041 ttagcgccag gcctgcgttt ggcttatgta gcagtgccga gacaatataa ggagccaata 503101 tcaaaggcgc tttataattt aaatataact gtttccccgc tattagctga acttactgct 503161 cgcacgattg tatcaaatca atttgaagtc ttaattgaga gtcatcgtga acaaaccatt 503221 cgcagaaatc aactcgtaaa ccgatatgtt gcgggatata catgtttagg tgttgaaaca 503281 ggcatttttc gttggttgtt gttaccgggt aaaatgtctg gtgccgaatt tgaagaattg 503341 gctgctcgac ttggcgtgca agtgtatgcg gctgaacgct ttgtagtggg aaatagttgt 503401 cctgaaaggg ctgtaagggt ttctgtctgt gcaccaaaaa cacttgaaga gcttgaacaa 503461 ggattaatga tcctgagacg tttgctagac gatcttacct aatattgttt gccatacaat 503521 tatgacattg tatggctttt ttgtgcgtgt tatgatgatc cacatctaga gggaggttta 503581 tacaaaattg gcttttagaa aggaaggtca gatgatgtta gacaaggaca gcgtaaaagc 503641 aatagatgtt caaactgctt cattacagag ctacatcagt tcaccagaaa aacaaaaatc 503701 gttatacaag cgtacactat tcgttgtgag tatctcacaa atttttggcg gtgcggggct 503761 ggcggcagga gtgactgtcg gtgcgcttat tgcacagcaa atgcttggca ctgatgcgtt 503821 tgctggtttg ccttctgctt tatttacttt agggtcagca ggatctgcat taattgttgg 503881 aagactttct caacgttatg gccgtcgaac aggtctttca gctggcttta tgattggcgg 503941 acttggagca ataggcgtta ttatggcagc aatcataaat agtattttct tgttatttat 504001 ttcgttgctt atttacggtg caggtacagc cactaattta caggcccgtt atgcaggtac 504061 agacttagca aatcataagc agcgagcgac tgctgttagt ataaccatgg tttttactac 504121 atttggcgca gtggcaggtc caagcttagt gaatgtgatg ggggatttcg ctctttctat 504181 tggtgttcca tcacttgctg gccctttcat tttagccgca gcagcatata tgttagcagg 504241 tgtggtcctt ttcattatgc ttcgtccaga tccattagtt atagcaagaa caatagaagc 504301 ggcaaatgaa gagcctggtg ataaaggaca tttggcggca actgagcata cagaaaacaa 504361 aaaagggata atcgttgggg caacggttat ggttcttacc caaatagtaa tggtagctat 504421 tatgacaatg acaccggttc atatgagaca tcatgggcat gacttgggtg cagtcggtct 504481 tgttattggt tttcatatag gtgctatgta tctcccttca cttgttacag gtgttcttgt 504541 agataggttg ggacgtaccg caatggctat ttcctctgga acaacgttgc ttttggcagg 504601 tgtaatagca gcatttgctc cgggagaatc tatgattctt ctcgtcattg ctctttcttt 504661 actgggatta gggtggaatt ttggtttgat aagcgggact gcccttattg tagattcaac 504721 tgatactgcc acacgagcta aaacgcaggg gacagtggat gttctgattg cgttgtcagg 504781 agctgctggc ggagcattat ctggaatgat tgtggcaggt tcaagttacc tcgcattatc 504841 acttattgga gggattttgt ccttattact cattccggtg gtggtatggt ctaggggccg 504901 ctaaagggta ggattgttta atttacatta atttgttata ttgttagata aagtatattg 504961 cagcatctaa tattctaacg aactatagtt gctccattaa atctattata aagatttgac 505021 caggattcct tatagctgtg tcactcactg catattcttt aattgaatca cataaaatgg 505081 ttatcggatt tgaaaaaggc aggattactc gctttaggta aaggagtcat aacgttgtta 505141 aaaaggtttt ctcttgttat tgttacacta atgatgtcta tcgttgttgt tttagcggct 505201 gctaaagagt cgcctggaga tcatgtcatc tcatttgatg aacctattat cttgatgatc 505261 tcaattggaa tcgttgtatt tttattgatc cctccattag tcatgtcctt ttttggcaat 505321 ttggttgtaa gaataatatc tggtgtatac caatgtttta tcgttttcac ttttctgggg 505381 ctcattccaa ttggatttct tattcccaat ggctttttga caattctagt ttctattgca 505441 ggaactttag tcagtatagc tagtgttgcc gtaaccttat gcattggcaa gaataaaaaa 505501 gatatataat catcgaattg ttattttttc agattgtcag tgaaataatt atacaaaaag 505561 agaaggcttg tgggccttct ttttttgttg ttgcatcatc cccactttga gcttaatcta 505621 ttgaataata agagaaggaa cctatagaag aataaaataa ataccgagat gtcaaaaata 505681 aaactggact tcattattgt gaattcacgt aaatgtaaaa agattggaaa gaggggaatt 505741 ccttcatgac aaatagcaga acaaatccga aggttgatga atttttaagt aaagcgaaaa 505801 agtggaagga agaatttgag aagttgagaa ccatcattct tgactgtgag ctgactgaag 505861 attttaagtg gatgcatcct tgttacacat atcataataa aaatattgtt ttaatacatg 505921 ggtttaaaga atattgcgcg cttctgttcc acaaaggcgt cttattacag gatacagatg 505981 gaattctcat tcaacaaacg gagaatgtac aggcggcgcg ccagattcgg tttacaaatg 506041 ttcaggaaat aaatgagcta gaaaacattt tgaaagccta tattcacgaa gccattgaag 506101 ttgaaaaagc cggtttgaaa gtggatgtta acaaaaatat tgaattgaac attcctgaag 506161 aacttcaaaa taaattcgat gaaatccctg cattgaaaat tgcttttgaa gctttgaccc 506221 cgggacggca aagagcgtac actctttatt tttctcaagc caaacaatcc aaaacccgag 506281 aatcgagagt cgaaaaatat gtgcaaaaaa ttctcgatgg aaagggatta aaggattagg 506341 cacgccaagg ttcaggctaa aggaatagca tcatagcgta ataagatcat ttctatagaa 506401 gaaaaacaag catagtaaga tgcttgtttt ttcttaggac aacattcact tactgctgaa 506461 atgcttctaa cattgtatgc cactagacag cgttataaaa tattaatgca acacctagaa 506521 atctatccaa tgaaatagct caatggtatg gctcattaca tttagaatgc ctaggagaac 506581 taatagaacc ggaagatttt tagcaagtta ctacactcca aactttgttt ttgtattaat 506641 ataccttatt aaccattgtt tttagtcagg tgcagacaaa cgaatactga ttaatgaatc 506701 atcatgatat caatgagccg cttgattttt tcatcgtcgc ctgtatcaac gtacactgtt 506761 tttctgtttt ttatgatact ctcagtcact tcccgcatga cgcctttttc tatatcatca 506821 gcggaatccc agcgtaaagg cacattatat acatgaattg tgccatcccc attgccatga 506881 taagtgactg atccatccac taaacgagaa cctgccaact gggtcacatt ttctggatag 506941 ctggcacttg tatcatcatt aggattaatt ggctcgccag ccgcaatatg tcgaacattt 507001 aattcatcta tctcttgatt aggtccaagt tgaagccaaa ctctggcata ttcaattttt 507061 tccgaagagt atgctgccaa tacattgtct tctttgcttt tctcttctgc tgaagaggta 507121 tcatttgcag cttttgttgc ggattcttct gattctgtta ttggctccgc ttcatccttg 507181 cgtattttgg tgctctcttc aggctcagtg tgtttttcgt cagtttgcac agcagaagct 507241 tgatttgaag gttgttgtgc ttctccatcc ttactgtccg tacatccagc aagcaaaatc 507301 ataagcagca gggcagtatt gcaataacat atctttctgc gtttcttcat tttttcattc 507361 ctctctatta attcaggtca gcttcatata taagtttatg tatctaaata ttaccatgga 507421 atagatagga tgatattgaa aactgtttaa gaagaggaaa cgatcttgaa tagcatcgcg 507481 aaaacctaag aatcttaaga agttttgccc ctttttcttc aggtattgaa tgtaaagtgg 507541 gatataaatg caaacaaaaa cgaaatgcct tatccacctc gtgtcatggc agaaaaagtg 507601 ggggatttat tagagcggat ttgataatgg cggcaggtaa atgggtgttg acttatatgt 507661 ctaagcggga gactcaagtc tgctcgatcg catacaaaat accaagggcc agcaaccctt 507721 ggtattttta taccttcatg catttttgaa gtttatgctt aaaggtctgc cttactttgc 507781 aaatcgccga gctgctgcaa cgcacatgat aacggcgata ttcactgcta cgagtgccca 507841 gcccactttc tcgtgcagaa tcactgaggc aagcagcagt ccaaaaaaag gctggagaag 507901 ctggagctgc ccaaccgctg caattccccc ttgggcaaga cctcgatacc agaacacgaa 507961 gccaatcagc atgctgaata aggatacata tgcaagactg agcagtgcgg gaacgccgat 508021 cgccgaccat gagtccggcg taaaaaagaa cgacaatggc agcataagag gaagcgacag 508081 aacgagtgcc catgagatca cctgccaatt ccccagacgc cgtgaaagtt tggccccttc 508141 tgcataacca agaccgcata cgacaataga agccagcatg tacgcgtcgc caagcgggga 508201 tgaacctccc ccctgaatga gggcgaaacc tgctactaac aagctgccgg cagctgagaa 508261 aatccagaag acggggcgag ggcgttcacc cccgcgcagt acgccgaaga ctgccgttgc 508321 gagtggaaga agtccaatga agacaatggc gtgtgcggat gtgacatgct gaagcgctaa 508381 agctgtcagc aacgggaaac caatcactac gccgaacgct accactaaca atgaaatgag 508441 atctcttttg gcaggatgct gctgccggaa gatgagaagg agacctcccg ccagtacacc 508501 agctatcgca gcacggcaaa ctgtgagaaa taacggatcg aagtctgaca cagccaaacg 508561 ggtcgcaggc agcgagccgc tgaaaatgag tacgcctata aaaccattta tccagccatt 508621 tgttgttttg ttcattataa tcactccaca tatctttctt gttcattgtc tgtattttct 508681 taacaaaacc agcagctaag gattacaatg actataaact ggaattggcc ttttataaac 508741 agccagtttt cataaaaaaa tgcataccag ttaggagaac aacgcgcaaa tggatatcac 508801 gccttttttg aatagaactc tggatattcc gctttatcag cagctttatc ggtattttaa 508861 agaaaatatg catcggggcc gtattcaaaa aggaatgaag cttccttcaa aaagactcct 508921 ggcgaatcag ctttccatca gccaaacgac tgtagaacgt gcctatgaac agctcgctgc 508981 tgaaggttat attgtgagca agccaagaag cgggtggttt gctgattatc atgattctga 509041 ttttgcttat gatagaatgc caagcacaac acccattcaa caagaagcag aagaaaataa 509101 acaatggatt gattttcatt atgggaatgt agattcttct tacttccctt tttccgcatg 509161 gcgaaaaagc atggtcaata gcttagacca atatggacac gagctttatc ggccgggaca 509221 tgttttagga gagtttgagc tgagaacact cattgcagag tacctgtatc aatctcgggg 509281 ggttcattgc ggccctgaac aagtgattat aggtgccggg aaccctattc tgctgcaaat 509341 cttgtgccaa gtttttgagc cgaatatttc tatagggtat gaggatcctg gttatccaag 509401 agcacgcaag atttttgaag ccaaccgcat gaatattgtt cctataccag tcgatgatga 509461 gggaatctgt atacagaaga tcaaagaaca gcagccaaac cttgtatatg tcacaccttc 509521 ccatcaattt acgctgggaa ccataatgac aataaacaga agaattcagc tgctcaaatg 509581 ggcggccgaa aatcaatcct ttatcataga ggatgattat gacggggaat ttaggtacac 509641 aggacagccg gttccttctc tgcaagggct tgatcagcat aaccgtgtca tttatatggg 509701 cactttttct aagtctcttt tgccctcgct gcgtatcagc tatatgattc ttccttcgcc 509761 tcttttaaaa aagggtcatg aaatcacgtc cttatataag cagacagtgt cctgccacag 509821 tcagctaacc ctagctgaat ttataaaaaa tggagagtgg caaaaacaca tcaacagaat 509881 gagaaaactt taccgcaaaa aaagagccat tgtattagag gcagtgcaaa gggaattagg 509941 agagcatgtc agaatccgcg gagaaaactc tgggcttcgt atcttacttg acgtttattt 510001 gccatttggt gaaaaagagt taattgagaa ggcgaaaaaa catggagtaa aaatttatcc 510061 tgtttctctt tcttatcaac atcatcctcc tacaaaaacg gtctcgctcg ggtttgcagg 510121 ggtttctgaa tccgacataa gagaaggcat aaaaaaactg aaggctgcct ggaagatatg 510181 agggagcttt cagtttagca aaacggccaa gtgacgacta agtgttgaga gctgttcaat 510241 attttttaag tatatgatga gtgcctgcag tccaggccac gatacgtctg tttagcgaaa 510301 aacagaattt tttatttgct cctcacagtg ctaaaataaa caaaatagac aattgaaaaa 510361 atagaggtgt aagaatgaag ttagatgagt ttacaattgg ccaggtcttc aaaacgaaat 510421 cattaaaagt atcaaaagat gatattatgc ggtttgcggg tgaatttgac cctcagtata 510481 tgcatgtaga tgaagaaaaa gcgagtaaag gcagatttaa tggaattatc gcttccggca 510541 tacaaacact ggccatatct tttaaacttt ggattgaaga aggtttctat ggagacgata 510601 ttatagccgg aacagagatg aatcatatga cattcataaa acccgtatat ccggatgatg 510661 aattgtttac aattgttgag gttcttgata agcagccaaa gagaaatgaa ttgggaatac 510721 tcacagtatt gctatctact tataatcaaa aagaagtaaa agtgtttgaa ggtgagttat 510781 ctgtattgat caaacgataa ctcagaaagc ccgcttttcg cgggctcgat tgaagcagat 510841 gggtgaaaga tgttagcggg tttcctttga aaaataagag gttaaaacat cataaacaat 510901 aggcaaagaa gtaaatccct catcttctag aaaatgacct ccgtgctgaa cttcatataa 510961 cgcagcatca atttgttgtg ccagatcctt gctgaatgaa aaaggcacaa tttggtcgtc 511021 cttagaagca atgacagcac ggtgcttcgc ggactcgatg attttttgat gatcaaacga 511081 tccctgtgta aattcatcta acatctgtaa agtgggcaat gatttggcaa agccggaaac 511141 aagtatgatt ccgccaagct gttttcgtaa ttgaagatgt tccaaaaatc tcaaaatggc 511201 ggggcaacct aagctgtgcg caaccaaata cgtattttca tgtaaagtgt gctgatataa 511261 agagagtgta tccagccaat cctcaagtct tggctggagc ggattaggca tgtttaaaat 511321 gtctgcttgg accccatctg cgagcagacg ttttttcagc caagggaacc aatgatttgt 511381 tgaggaggct ctgtagccat gaatgatata gacttgtttt gtcattattt cctcctaaga 511441 aatattttca ttcagtataa aattcctctc attgggaaac aagtacgcac ttttttgtaa 511501 gtagctttac atatgaggcc ctccttgtgc cattccccac ttacacatct catctatgag 511561 gggatacaaa gatcgccctc tgtcagataa cgaatactct actttcagtg gggtgtgaga 511621 aacctcagac cgatgaataa ggccgtcagt ttgcaattcc ttaagctgtg cgcttaacat 511681 tttatgggtg atgaagggca tagccctttt cagctcgccg tatctcatcg ttttttcaca 511741 ccctaactca tagagaattc tcattttcca tttgccccct ataagagata aggtgtattc 511801 aaatggggct tgtttactgc ggcacaggct attcattgta atcaaacctc cttttttaag 511861 tatcatatca gaataaatta ggattttcgg tgttgaagtt tgagggcgat tcacgatctg 511921 aagtgaaagg ggccgcttgc tcaacaggcg gcacggtaca tgaatgttct aagtcaaaga 511981 gggttacctt actgttagtt actttattta aaaaaacgca tgtttttagc tgaaaatatc 512041 tattatggta tatttaaata taaagaaata tttgagaaat gaggaatggt atgaatacac 512101 ccaaaaaaca taagaaattt aaagcgaaaa tgattctcca aatcatcatg gttatcattg 512161 gaggaatcat agcggcatat ggactagaaa cagtgctcat tccaaacagt gtatctgatg 512221 gaggggtgac gggtcttagc atcgttggtt cacagctatt caacttgccg ctggggattt 512281 tgattgctgt gatcaacatt ccatttgtct ggttaggata taagcaaatt gggaaaagct 512341 ttgcattatt atcaattatc ggaatcgtat cgcttgccgc ggggacaagc tttttccacc 512401 acacacccgc tatcatagaa ggagataccc tgttaattac cgttgtcggc gggattatcc 512461 ttggattcgg aatggggctg gcgctgcgta atggcggcgc attagatgga attgacatgc 512521 ttgctgtgct gctatcccga aaactgccat tcggaacgag cgatctcatt ctattcttaa 512581 acctatttgt gtttattttt gtttccacag tatttggctt acaaggggca ttgctttcag 512641 tcattgctta ctacattgca tccaaagtga ttcatgttgt ggaggaaggc ttaagcggct 512701 ctaaaacctt tcaaattatt acaacccaac ctgaattaat ggtagagaca atacgtgatc 512761 aattaggccg aagcgccaca tataaagaag cttacggggg tttttcccac gagaaattta 512821 aagaaatcac atgtgtcatc aaccgtttag aagaaaccaa actaaaggaa attattaatg 512881 atattgataa aactgccttt gttaccgtgt atgatgtagc tgaagtgaag ggcagcaatt 512941 ttagaaatct taatcatcac taaaaaatag aatgaccttt ttaaccgtaa ctgacatgcc 513001 gcgggtaatt taatcaaaaa cacttttttg aggcttgtgg gtgaataacc ggtgaaggtc 513061 tgaatcacag aaataccaag ggcgtcaaaa cccttggtat tttttctggt tattagattt 513121 tatcttcagc tttacgtgct gcttcgagct tatcaatcct gtctttatat ttttctcccc 513181 agtccttcat gtgcaggata acaggttcta atgttcttcc aaactcagtt aaagagtatt 513241 cgacttttgg agggacctgt ttataaacct cgcggtgaat cacgccatcc cgttccaatt 513301 ctcttaattg tagcgtgagc atacgctggg taatttttgg gtatagtttt cgaaactcat 513361 taaacctctt tttaccgtca atgagatgat aaagaagaat gcctttccac ttacctccga 513421 tgatatctaa tgttgtctcc accggacatc cttcaaagtc atcagaagaa taatcaatgc 513481 cgagtttacg atttctcaag ctgttcactc ctaatagtat actttttgat actatataca 513541 ttcaatgtgc gtacttttta tattttaata tacatcatat aatgatgtca catctaagga 513601 atgaaaggaa tggatcatat gaaaacactc gtactcgttg tacatccgaa tatagaatcc 513661 tctcgtatca ataaaaagtg gaaagaagcc gttttaagtg aaccagatgt aactgtccat 513721 gatctttatg aaaaatatcg cgatcaacca attgatgtgg aatttgaaca acagcagctc 513781 ctggcccatg accgtatcgt ttttcagttt ccattatact ggtacagcag cccaccgctt 513841 ttaaaacagt ggtttgatga agtgtttacg tttggctggg ctcatggtcc cggcggaaat 513901 aaattgaagg ggaaagagtg ggtaactgcc atgtccatcg gttcacctga acactcttat 513961 caagccggcg gatataactt gttttcgata agcgagctga caaaaccgtt ccaagcatct 514021 gcccatttag taggcatgac ctatctgcct tcctttgccg aatatcgcgc caatacaatc 514081 agtgaccaag aaattgccga aagtgcgaat cggtatgtaa agcatattac aaatatagaa 514141 ttaaacccga aggttcgcct gcaaaggtat ttgaaacagc tggagagtgt cgatttaaca 514201 taaagattga tttttgaaaa tcctgtactc accaagcagg attttttctt gttcagcaga 514261 gggattttaa catatagcaa aaaaagaaga agccaccaaa aataagctat ttgcttggtc 514321 ctgactgctt atttttggtg aaatacttat ttctctgtga tgaaataaag caaagcgatg 514381 accggaaaag cgattccaat ccataatgct gtactccatc cgcctgaggc atatgcccat 514441 cctccaattg atgaccctat cgcaccgcct agaaagaaga tcgccatgaa taatccgttt 514501 aatcgactgc gaatttcagg cgccaacgaa aaaatagcac gttgactgag cacaaggttt 514561 gcagatacac ccatatctaa cagaatagca gcggccacta gaactgttat accgacgggg 514621 gagctgctct gaatcatgag cggcagtaat aaagagacaa cgacaacacc gagagcgatt 514681 ccagtggcaa gcctggttaa gcctcgatca gccaggcggc cgcctattgg tgcagtgact 514741 gcacccgcaa tgcccaccaa tgcgtagagt gctattgcct tctgagaaaa atgaaaatca 514801 ggaccggaca ataataaagg aacagttgtc cagaacaagc tgaaagctcc aaatacaaac 514861 gcatgataga tggcacggcg gcgtaagact ggagtcgtgc gcagcagctt ccacattgaa 514921 ccgagtaagg cagtatagtt tgtatttgct gttggttttc tggcaggaag cacttttgat 514981 aatacgatgg ccaggataac acttaccacg gcggacaaag cgaatattgc attccacccc 515041 cagatatcag cgactagact agatatcgga cgggaaagca taataccgag taataagccg 515101 ctcatgacat tgccaacaac ccggccgcgt gcagcgtctg atgcaaggta tgatgcaaat 515161 ggaacaagca cttgggctgc gattgatccc aatccgacga aaaacgcagc tgctaaaaac 515221 agtgttccat gcttcacaaa tgctgttagt gtcaaagccg ctgcgcttag aaggagcgat 515281 acaacaataa gttttttgtt ttcgataata tctcctaaag ggacaaggaa tagtaagccg 515341 gcaacgtatc cgatttgggt gagtgtgaca atcaatccag caccgcttgg agaaagtcca 515401 attgccttac taattaatcc gaccaagggt tgtgcatagt aaagattagc aacaatgata 515461 ccgcatgcag ttgcgagaag aagggttaaa ctgggtgaaa tcctctgacc tgcttgtttg 515521 tttccattag ccatatgaat gaactccttt ttaagtggtt ttttgagtgt aatcatgact 515581 tctcacaagt gattttataa actgaacgtt cagtttcgtc gattaataaa aataatatac 515641 taaacgttca gttttgtaaa tggatttctg ttttcttttt ttattcaatt taagtatact 515701 gaacgtatag tttatattgc gggaaggaat gatttatgtg cagagtaaac gagggcggcc 515761 gcgtgatgaa ggaacgcata aggcgattct ctctgcagcc tatgacctat tgctggaaaa 515821 aggcttcgat gcggtgacag tcgataaaat tgccgagcgt gcgaaagtga gtaaagcaac 515881 gatttataaa tggtggtcta acaaggctgc cgttatcatg gacagctttc tttcgaccgc 515941 gacggacagg ctgcctgtgc ctgatacagg gtcgtcagta caagatatag taacccacgc 516001 cacgaattta gctaggtttt tgacaagccg ggaaggaacc gttattaagg aattaatagg 516061 tgcagggcag ttggatgaaa aattggcaga agaatatcgc acgcgatttt tccagcctcg 516121 ccgcctccaa gcgaaaggcc ttctagaaaa gggaattcag aaaggtgaat tgagagagaa 516181 tcttgatatt gaagtaagca tagatctcat ttacggacca attttctatc gtctgcttat 516241 aacaggggat gaggtgaatg attcctatgt gcgtgatttg gtgatgaatg cgtttaaggg 516301 agttcaagct acctctgcta cagagagtat gtagctgata agaactgcaa aagctgcgga 516361 ttatatgaca aattggttcc atcgtacagt gaaatataag atttttgttg ctgagcggaa 516421 tcatcgaggg aaaagttctc ttatcggatg tcgaaaaaga agtcattcaa tcgtgaatac 516481 ataacatcat attattacat tccttttcat cgattggaac aagggttcta tacttcaatg 516541 gaataccgca aagttggagt atttaaacaa caggggaaaa tcgatggcca ttatgtaggt 516601 gtcatggcaa tggaaaaaat acttgcaatg taaacaggcc tctaaagaga cctgtttttt 516661 aatatccaga tgattgtcta gtttcagctt gggctctatg accactccca taactgaaat 516721 agtctaatat ttataccaga agggattgtt tatataaata aaagtttata taatgacggg 516781 ggcgctaagg aaacgcgggg agcgactcag gttttcgttt caaagttttg atccttaaga 516841 tatacggagc gctacatatg gaaacgtaaa ggggaatgta taatcatttg gcgtgtatat 516901 aacgatttgc ttatatattg atttgggaag gaggagctca tatgacgatt gatgttgcgg 516961 cgatgactcg ttgtttgaaa acacttagtg atcaaactag gcttatcatg atgagattat 517021 ttcttgaaca agaatattgt gtctgtcaat tggttgatat gttcgaaatg agccagcccg 517081 ccataagcca gcatttgcgg aaattaaaaa acgcaggttt tgtgaatgag gacagaagag 517141 gccaatggcg ttattattca ataaatggtt cctgtcctga gtttgataca ttgcaattga 517201 tcttacatca aattgatcaa gaggatgaat tgttaaacca tatcaaacaa aagaaaactc 517261 aagcgtgttg ccagtaagga ggcattagat tgacatcaat gattttggca gtattcatct 517321 ttttattaac tctagtattg gtcatatggc agccgaaaaa tttatctata gggtggtcag 517381 cctgtggagg cgcagtttta gctctaatag caggtgttgt caattttcat gatgtgttaa 517441 ctgtgacagg gattgtttgg aatgcgacct tggcttttgt ggccatcata ctgatatcgt 517501 taattcttga taatatcggt ttctttgaat gggcagcgct tcatatggct aaggctgcaa 517561 aaggatacgg tgtgcggatg ttcgtttatg tatctctatt aggagctatc gtcgccgcgt 517621 tatttgcaaa tgacggtgca gctcttatat tgacaccaat cgtattagcg atggtcagag 517681 cattacattt taatgaaaaa ttagtttttc cttttatcat tgccagcgga tttattgcgg 517741 ataccacttc gcttcctttt gtagtaagca atttggtcaa cattgtttca gcggactatt 517801 ttcatattac gtttattgat tatgcatcca gaatggttgt cccgtacctg ttttcgctgc 517861 tggcgagcat cattgtactt taccttttct ttagaaaaag cataccaaaa cgctatgatc 517921 tgactgaggt taaaaaacct gttgaagcaa ttaaagatca aaacatgttc agactgtcat 517981 ggtatatctt agggctgctg ttaattggat attttgcaag tgaatttttt tctatccctg 518041 tatcagtggt agcgggcagc attgcaatca ttttcttaat cgctgcgcaa aagagtccgg 518101 ccgtccatac aaagaaagtg gtgaaagagg cgccatgggc tatcgtattc ttttcaattg 518161 gcatgtacgt tgttgtgtat ggtgtccgaa atgccggatt aacggatgtc ctttcagatg 518221 tgattcaagc cgcagctgat caaggattgt ttgctgggac aattggaatg ggctttattg 518281 cggcgattct ttcttccatt atgaataact tgccgactgt tatgattgac gcattggcca 518341 ttgccggtac agatacacat gggatgatga gagaagcgct tatttatgca aatgtgatcg 518401 gttcagattt agggcctaaa ataacaccga ttggttcctt agcgacatta ttatggcttc 518461 atgttctttc gcacaaaggt atgaagattt cctggggcac gtattttaaa acaggaatta 518521 tcctcacgat acccacttta ttgatcacac ttgtcggcct gtatatttgg ctgctgataa 518581 tccattcttg tttctaaaag gacaaggtca ctatatcaag gaaaacaatg cactggtaac 518641 tcttgccgca gccaaatggc tgaagggtgg gggagaaaat accttggggc taagtggaat 518701 gtgtacagcg caggaatcga agctcaagga tgacatcgag tgctgtcaaa gcaatgaaag 518761 aagcagggat tgatatttca aatcaaacat cggagaaatt tgatgatccg gcaaaagcac 518821 acggaacaga agaagtgttt ccaaagggtc cgtgatgaaa ttggtgaccg tttaaaacag 518881 tttgctgtaa ctggggaata aagaatcgat atattcagcg ttttcttggg ttatataata 518941 caatgtgttg ttcaacaggt gtctgcgagc tgagtgcaga cacctgtttt tgtttttatt 519001 tgtctgagat tcgtaacagg gaagttattt agctggtgac agaggaaaat tgatttgtga 519061 acagaatcat gaaggagacg gtgttttaaa ggagttgtct gttttgcagg aattaacaaa 519121 aaaaaaatac agtagcttaa aaacaatgtt tgatgacaaa tattgtccca catttgtcta 519181 ttcaatatta gaccaaacca ttccgggagc tgtttatgca gatgatcaaa cctttcctaa 519241 atcgtttttt ataggaactg aatcaggcat ttattttatt gcgggagacc aagggaatcg 519301 ggattttcat gatttcattg caggatatta tgaagaacaa gtgaaatcat caaaacgatt 519361 taccttgttt tcttccagtg atacatggga tagcgtactg aaacccatac tgaaagatga 519421 cttaaaccaa atgagaagag ctgcattttc ttatcaacca aaatctttca aaaagacttt 519481 gcaactgcca aaggggcttg tattgaaaag aattgacgaa gacatcattt cacatagcac 519541 agcgtttaac agcgcgtatt atgaggagta ttggaattct gtctcacagt ttgcttcaaa 519601 aggttttgga tttgccgtat tacatggcaa tcacgtagta agtgagtgta cctctatatt 519661 tttagggcat aatcgagcgg aaatggatat ctatacactt gaagaatata gaggactggg 519721 gttagcttat tgcgtagcaa ataggtttat agcgttttgt atggaaaatg ggattgttcc 519781 tagctgggat tgtgatattt gcaacaattc gtccattgca ttagcagcta aactagggtt 519841 taagacggta acggaataca ctatttacta ctctggctaa ccttaatgaa agaaccttaa 519901 aaggagatac caaccgatgt tggtatcttt tttgttttag agttttttta cccttttagc 519961 agaaaaatgg gtgatgaaaa tcttattcat tttatttact tttaggtagg taaaacatac 520021 cccgccaact gtaaccactc cgcctagcag agagagcagt gtgggtatct cgccgatcca 520081 gagccaagat atgatcaagg ctaaagccgg tgtaacataa agtgaaaggg ttgcttctga 520141 agcaccgacg aatgaagtga catatgctag tgcgaagtaa ggaataaccg tcggcaataa 520201 tcctaagtaa acgatagaca aagttgcgct tattgaagcg ttcatcatct cttcgcctaa 520261 gcctggcaga aacacaagca taggtattgt tccgccccaa atggtgaatg taacgaatgg 520321 aataaaacca tattttttta tatagcgggc ttgaaaaacg aaataaatac tctccgaaaa 520381 tgctgccagc aggatgacca agataccgct cattgaatat gtaaagtctc ccgccccaaa 520441 tgcaatcaat aatacaccca ataaactgat catagagcca agccatttcg taaatccaaa 520501 atgctcttta taaaacaggc gggatagcat ggctgagaag atcggtgccg tagtaacgag 520561 taagcttgca actccggcac taactgtttt ttcaccgatg ttcagcaaaa tgtgatagaa 520621 tgcaaatcct aaaaacccta aaagaaaaat ggcaggaatg tctttcaagt cgggtaggcg 520681 catctgagtc aaaacagcaa aaagcaataa tgccatagag ccgattaaca aacgaaataa 520741 agcaaggtgt tctggcgtgt acccttcaag tcctgcgcga attcccggaa aagcagatgc 520801 ccataaacca atcatgagac tatgagatat cattatttga actgttttct ttcgcattcc 520861 tctcactcct ctttacaaaa accaaccagt tatttaatgt gtttctatac taataaagat 520921 ttgatgatat ggcttcaacc agttcaatag attttgaccc aaccaattta ttttaaggag 520981 accgattcta tgagctttcc agaagaaaaa aagatgaaaa agctccctaa gtacagacaa 521041 atcgttcatt ttattaaaga gaaaatagga aatggagagt ggccgattgg aagcaagatt 521101 ccaagccagc gcacgcttgc aaaagatttt caggtaaatc ggagcacagt gattacagcg 521161 ttagaggaat tgatggccga tgggctaata gaaggcacaa tggggaaagg cacagttgtt 521221 atcaacaaca catggacact gatggctaag aattctgctc ccgattggga tcaatatgtc 521281 acctctggca ttcagatgcc aagccgaaaa atcgttcaag agataaatca atcagaatca 521341 aatacagacc ttatacagct cagtaaaggt gaactttcag ctgagatttt tcctttggct 521401 gttatgaaag agatgatggg gaaggtatct caacacatgg aggcattcgg atatgaagaa 521461 ccaaaaggtt acttaccttt gagggaggca ttaagcaact atttaaaaac cattggaatc 521521 aacgtctcat cttcttccat tctgattgtc tcaggagcgt tgcaagcctt gcagctgata 521581 tcaatggggc tgttacaaag aggatcaacc gtttatcttg atcagccctc ctacctttat 521641 tcattacacg tatttcaatc agctggtatg aagctgactg gacttcctat ggataatgaa 521701 ggacttttgc ctgaaaatgt tcatttaaca agaggagagc ggggaagggc tatcttatat 521761 acaaatccat gttttcacaa tccgactggt attcttatgt ctaaaaagcg acgggaagaa 521821 atcctagcag taagtgagaa tacacagctt cctattattg aagatgacat ttatcgtgag 521881 ttatggatcg atgaaattcc gccatatcct attaaaacaa ttgataaaaa tggacacgta 521941 ctgtacatag gaagtttatc gaaaacatta agcccaggtt tgaggattgg atggatcgtc 522001 ggaccggaac cggtgattga acgtttatct gacattaaaa tgcaaacaga ttacggatcc 522061 agttcgctat cccagagagt agcggcagag tggtttactt ccggccacta ccagcagcat 522121 gtagaaaagg ttaggcagca attaaaggtg agaagagaat tggccttgag tgctttagaa 522181 actcatttga aagaagtggc gacatggaat atcccaaaag gagggttttt tgtctggata 522241 aaaatattgc cttccatatc aatgaaatta ctttatacta aagccttatc aaaagggatt 522301 ctgatcaatc tcggcagtat ctatgctcag gaaaaaggga attatattcg cttatcatat 522361 gcttatgcat ctcttgaaga ccttcaaaag gggatttatg agttgggttt aatgattaaa 522421 gaattggcaa gcaggtaact tttatatcct taaatggatg tttcactaaa aaagagatca 522481 agcctaatga tcgcttgatc tgataataac aagggttact agaatagacc aaatcatggt 522541 tcggtcttaa aataatcatg tctctgaacg aaaagtcttt ccgacttctc ttcctaaacc 522601 aaagtagtgt ctgaaattat agataagcgg gctccatttg gaagggttga tatggttttc 522661 gtccagaatg atactttcct cggcatgaaa atgtagtgcc tgcgtctcta caattgcgaa 522721 tgacgattca tattctggaa gccgaatgtg tttcacttcg gcttcgattt ggatagggca 522781 ttctttaatt cgtgttggtg atactgtttt tgattgtaaa ggcgttaacc ctgctgcctc 522841 gtatttttct tttttatatg taaatccgat ctgcttcttt aaaggcggta tactcttttt 522901 tccgctataa gatgaaattc tttcaacgtt ttcccataaa tccgggccag gcaagtttat 522961 gacacactct ttgtgtcttt ccaaattgtc gatggctttt cctcccagtc ctactccaag 523021 gattatataa tgtccaagag cccaagaaga agacatagga ctaatattag tggttccatc 523081 ctcattcaat gtggttagaa gaaatgtcga ggtaccataa tacatgatct tgggtttgat 523141 ttccttaaat cgacgagtgt cttgtttttt gatgtccaac gttttttcct ccttgtcacg 523201 cttacattta tattgtaaag gattaacatt tcaactatca tcgaaatatg aatgtaagga 523261 ggaaaatcat gaatcctaat attgcaaaaa tctcttcgtt gctatcagat ccctcgcgtt 523321 cttccattct tctcagtctg atggatggaa ggatacaccc tgcgggagag cttgcatatc 523381 tcgctaacat taaacctcaa actgcaagtt ttcacctgaa taaattgctt gaagcaaagc 523441 tgattagcgt agagaagcat gggagacatc ggtattacag attggctgac tcagatgctg 523501 caaatgtgat cgaacaattg cttcatattg cgcctaaagc aaaagtcaaa tctttaaaag 523561 agtcaaaaga gaaaaaggac ttgcatttcg cccggacctg ttatgatcat ttggcaggtt 523621 atgtgggcgt gcaaatggca cattcactag ttgagcaggg gatgttaaaa aaagttgatt 523681 taaactttga ggtgacttca gagggtgctt tattcttttc gaagttaggc atcaatgaag 523741 agcaacaacg gaataagagg agagcctttg cccgctgctg tttggattgg agtgaacggc 523801 agcatcatat tgcaggagca ttaggaaacg ccctattggt gcgcatgtta gaagaagaat 523861 ggatcgttcg tatgcctaaa acgagagcga ttaggattac acaaagcggg aaaatcgcgt 523921 ttgaaaagca cctaaacgtg aagatttagg attttgaagc ggaaacatca gatgatgagg 523981 cacgatatct aggaggagta agatttgttc taatcttact ccttcttctt attttgaagc 524041 agctcgattc cccattgcaa tagagatgcg gttccaactg tttatttgat taatgatcag 524101 aacaaggtca acatattgtt cctcatcata atgttcccgc acccgatgat atagctcatc 524161 aggaaccctt ttagatggaa tgagcgtgat gtgttcagat agttcgagag ccgctttctc 524221 ttcaggtgag taaaaatcac attcattcca agcatgtaaa cagtaaattc gctgttcagt 524281 ttctcccatt ttgcgggcat cggacgtatg catatctatg cagaaggcac agccgttcat 524341 ttgagagact ctgattttga ttagttctct cgtcgttcgg ttaattgagg attgtttcgt 524401 gtatttctcc atatccatca tgattttcat accttcaggt gcaatctcat agtaggacac 524461 tctttgactc ataaagcaag actcctttcc atagaatacc tagattgtat cccggtattg 524521 atcattttac caatgtgcgg tttgaatgac agctgtttca gcgtcttttg gaaagaagct 524581 tctttgaata aaaataaggg tagccagcaa tgatgagtgg agctgctaat gcaagcagta 524641 tccatgagcc tgattggctg tctctagtga ctctaatgaa tatataagta ccgatcagaa 524701 aatataataa agcacctaga aaccaataca tgttcattcc tctttttcct tgctttttgg 524761 ttgcgcattt ttgtctgtca tatggcttaa tcgatcaggg ttctgatttt ttaatacctt 524821 ttcggtccgg attccttttc tctttaatga taaaattgtg agatcaatcg atttcaatga 524881 tgatcattcc ttcaatgaat agtaagttcc ttatgatttt aaaggtaaat ttgaaaagat 524941 aaaacgtaca tagaggcaga acgttcatgt acgtttgggc aatgatcact tgttggaaac 525001 tctaatgttt ccctgcacct gatattgttg tgttccttct cttcctataa aatgattgga 525061 tacatgtatg tttgcacgtt gaaatatggg ttcgattttc atgaatctct attcggtgaa 525121 acaggtaaag gaagtggata aggtttgctt ataaggaatc cttttaaaga taaatattac 525181 tcacatgata ggcgggcatt aaacatgctt gcactcagag tgccgggcct ggcttttatt 525241 ctcatgatct atatagcctc tatcgtgctg caatttgttt ctgggggctg gtccatttta 525301 ttgctttatg cgtttaccat attaatcgcc atttttgctt tgcttcattg gcactcatat 525361 cgctgggtta agaaaagagt gattctgtat ttcgcggtac aaggtttgat cacctttgca 525421 cttgctaatc tcatgactgg cttctttata cttgtgatta tcggccttta tgcattttta 525481 attggacaaa ttataggaat ggcagacaga agaaggactt ttctcattct ttatctattg 525541 ctgctgctgg tcataaattc ggcgtatcac cttcataaag gtgaagtttt gcattttatt 525601 gttattgctg cgccgatcat gattgtcatc atcacttatg ccgcaacatt ttttgcccaa 525661 gtcgatgaaa aaataaaagc tcaattgact cttgaaaggc tggagctggc tcatcagcag 525721 gtagaacagc tgacgctgca gaacgaaaga cagcggatgg cccgagactt acacgatacg 525781 cttgctcaag gtcttgtcag tttaaatatg cagctggatg cgattcatgt tcatctcgcc 525841 aaaggcaaca cagagagagc gaaggaaatc atacaacaat cgatgaaaag agtgaaaagc 525901 acaatagctg atgcacgttc agctattgac gatctccgca gcaaatcaga agaaatcggt 525961 gttttaaaag aaagaattac ctcgctaatg gatcatttta tagagtcgac aggcatggct 526021 tgtttattag attacagatt gcatcaggtg ctggatgtgc gtacagctga aaactgttat 526081 tacatcattg gagaatgcat gacgaatgcg gcaaagcatg ctgaggcgaa aacaatctgg 526141 atatccattt gggatgatga aaagggaagg ctccatttaa cagttaagga taacggcaag 526201 ggatttgatg ttgaaaaagg aaagaaaaag agaggacatt atgggcttct tggcatacaa 526261 gaacgcgtca gggcaataaa tggccaattc aatatcaaga gtacaaaatt gaaaggaaca 526321 caaattgaga tcactgtacc aattcaggga gagatgcaag atgaataagg ttttaatcgt 526381 tgatgaccat cttgtcgtga gggaaggtct gaagctttta attgaaacga atgatcaata 526441 caccattata ggagaggcgg aaaatggaaa agtagcagtc cgtcttgcag atgaattaga 526501 accggatatc attctgatgg atttgtatat gccggagatg agcgggttag aggccattaa 526561 acaaataaaa gaaaaacacg atacccccat cattattttg actacatata atgaagatca 526621 cttaatgatc gaagggattg aattaggagc gaaaggatat ctgttaaaag atacgagttc 526681 agaaaccctt tttcacacaa tggatgcagc catcagagga aatgtgctat tgcagcctga 526741 tatccttaaa cgtctgcaag aaatccaatt tgagcggatg aaaaagcagc gcaatgagac 526801 gcagctgaca gaaaaggaag tcattgttct aaaagcaatt gctaaaggtc ttaaaagcaa 526861 agcgattgcc tttgatttgg gcgtctctga gcgaacagta aagtccagat taacgtccat 526921 ttacaataaa ttaggcgcga attcaagaac tgaggcagta acgattgcca tgcaaaaagg 526981 tattctgaca atagacaact aaactgcata tttgaaaatt gcccaaacgt acatgcccga 527041 atgtacgttt ttttcatttc attgtcaact acaatgagaa agaatgtgat caagcaatgt 527101 gttgaaagga gattatcatg tcaaaaatgt tatatacatt aggaggatgg gttgctcgca 527161 atcgcataaa agcaatatgt gcgtggatcg ttgtgttagt tgctgcgata ggccttgcag 527221 tgaccttgaa accaagtttt tctgaggata tgtccatacc tgacacacct tcggaaaaag 527281 cgatggatgt gattcaaaaa gaatttcctc atggtcctga taaagggagc atacgggtta 527341 ttttcggtgc tggtgatggg gagaaactta ctgggaagcc agcaaaaaaa gcaatagaag 527401 atacgttcaa agaaatcagt aaagatgatt ctgttgactc gattgcaagt ccttttgtga 527461 cagggacaat cgcgaaagat ggcacagttg cctatgctga tatccagtat aaatcatcag 527521 cagatgatat aaaggattac tctatcaaac acttaaaaga cagtttgaaa atggctgatg 527581 atgaaggatt gcaaactgag ctaagcggag atgtaccggg agcggagatg gagataggcg 527641 gtgtctctga aattgtcggc attatcttgg cttttgtcgt tttagccatt acattcggtt 527701 ctttattaat agcaggtttg ccgattttaa ctgcactgat tggtttaggt gtaagtattg 527761 gactggtttt gattgggaca caagtatttg atattgcttc tgtcagtctt tcattagccg 527821 gaatgattgg ccttgctgtt ggtattgatt atgctttatt tatttttacg aaacaccgcc 527881 agtttttagg cgaaggcata caaaagaatg aatcaattgc gagagccgtg ggaacagcgg 527941 gaagtgcagt ggtttttgcc ggacttactg ttatcgttgc actttgcgga ttaactgtcg 528001 ttaacattcc ttttatgtct gcgatggggc tgacagcagg gcttagtgta ctgatggctg 528061 ttttggcttc catcacactt gtgcctgcgg tcttatcgat tgcagggaag cggatgattc 528121 cgaaatcaaa caagaaaata gaaaaacaaa gcactgaaac aaatgtctgg ggacgctttg 528181 tcaccaaaaa tcctatcatg ctaagtgtat gcagcattct gattttgatc gtcattagta 528241 tcccatctat gcatttggaa ctgggcttgc ctgatgctgg gatgaaagct aaggataatc 528301 cggatcgccg ggcatatgac ttgcttgccg aaggctttgg agaaggattt aatggccaat 528361 taacaatcgt agcggatgcc acaaatgcta cagaaaataa ggcggaggct ttcgcagatg 528421 cagtgaaaga aataaagggc ttagaccatg tagcaagtgt cactcctgca atgcctaata 528481 aagaagggaa ctttgccatc attacggtcg ttcctgaaac aggtccaaat gatgtcacaa 528541 cgaaagattt ggtacatgat gtacgcagtt tatcagataa aaacggagta gatttgcttg 528601 ttactggatc aactgcagtg aatattgaca tttcagatcg cctgaatgat gcgataccgg 528661 tgtttgctgt acttattgtt ggctttgcgt ttgtattgct gaccatcgtt ttccgttcgc 528721 tgcttgtgcc gcttgttgct gttgcaggtt tcatgttgac gatgacagcc actcttggaa 528781 tctgtgtatt tgtcttgcaa gacgggaatc tcatcgactt tttcaaaata cctgaaaaag 528841 ggccgatact cgcgttcctg ccgattttat cgattgggat tctgttcggg ttagccatgg 528901 attatcaagt attccttgtc agcagaatgc gtgaagaata tgtaaaaaca aacaatccag 528961 tacaagccat tcaggctgga ttaaaacaca gtggtcctgt tgttacagca gccggcttga 529021 tcatgatctt cgtttttgca ggatttatct ttgcaggcga agcttctatt aaagccaatg 529081 ggctggctct ttcctttggt gtactctttg atgcctttat tgtaagaatg acactgattc 529141 caagtgtcat gaagctgatg gggaatgcag cctggtattt gccgaaatgg ttagacaaga 529201 ttattccgaa tgtggatata gaagggcatc aactgacaaa ggaaatacag ccggaaatag 529261 atcatgaaca aaagaaacaa atcagtgtgt aatagaaaaa gcagatcttt tatgatctgc 529321 tcttttgctt atggtagtat ttagaagatg aagtcggcag ttaaaaggag acgcttatgg 529381 cgccatcact cattttcgat atggatggaa ctttgtttca tattggcaga agctgcatca 529441 tactagcagg catcccagga gaagtgacat gattttttga ctttgcattc actacttgat 529501 gccaaggatc ttgagaatcc ttcttgaaaa taaaggattt tacaactgat catataagaa 529561 acctaaagaa acaagcacac aaaaccagct gcgggttttg tccaagaaaa atagagtcca 529621 taagagggac tctatttttt gaagtgcccg gctagaagca tattgcagga ctttatgaat 529681 gcaaatcact atcttataag cccttaccgt gaaatgcctg tttctgcatt gaaaaaacgc 529741 attacacgtt catttacgta agtgggttgt tccatcgata aaacatgtcc ggcattttta 529801 atgacttccg cctcaatatc tggaacgaat gaagaggctc ggtgcagggc tgagtgggga 529861 tcatagatga cttcatgttc accaagtaat aataggatag gaactcttgc tgaacgtaat 529921 tcctcatcgg taaaaacata cggaaatccg tcggcattag gatttggatt tcttgatcca 529981 tcctgccaca ttacccctgc cttaaactgc ttcacaaaaa tcgggtgcag cacattctga 530041 tcattcatca tccaatttaa gaatgtttca actccatttg acgctgtaag gccaagagcg 530101 tatttgtaga aatcgtgatg aaatggcaaa aacgtttctg ccggactcag tatagctgcg 530161 ctttttactc tctcaggcat acgtaaaagg aaattcatcg tatggagacc gccaagcgaa 530221 agtccgatca tgtgggactt ttcgatcccc agattgtcaa acacatcaag aagccaattg 530281 gcgtaatccg ttcttgtacc gcttacattc tcaggaatac tcttgttttt atcacctatg 530341 atatcaactg cataagttct gtatttactg ctccaatcgg cgatgttggg ataccacatc 530401 gtcgagctga ataatgctcc gtggagtaat acaagcggcg gggcatcctc tgggccgctt 530461 gcaatcacat gtgtttgacc aaaacgagta gatatataga atgatttaca acggaccggc 530521 caaagactaa ggctttcatt ataagtttga taatagcgga taccgttgtc acttaattcg 530581 ggaatactag atgaatggtt tgacatacaa atgcccctcc caattttgtt taaatgaatg 530641 tgccgtttcg tgatggggaa tctgattttg atataacaga ctttatttac aatataatac 530701 agttgttatt agacgtcaaa tccaagatga aaaggaaaaa aacgattgaa acagattatt 530761 gaaaatcaat ataacagaat attaacctcc tttgtggagc cgcttcatta aaaccgcaat 530821 ccaaatgcat gaatcacaaa aatcacaaca ggagggatca ggagggaagg cagcagattc 530881 agtgttttga acttcttgat tccaagaatg cttagacctg aactgaggat gagtatgcct 530941 cccacaattg tgatttcatt aataaggtct gtattgattg cgctctccat tacttgtgca 531001 aataaataga tggagccctg ccaggaaaat aatacaagtg cggcagccgc tattccaaaa 531061 ccaaaagttg aagcgagcac aatggaggtg atcccatcta acatcccgtt tgtcagaagg 531121 tatgtataat ctccatgcaa agcggcttca acagggccta atattgacag cgaacctata 531181 caaaataata agaccgcagt tgataagccc tctgctaaat tgcttttaga aaatttgttc 531241 accagcttgt tgaatcgtaa ttctaaattg atgatctggc ctagcaaacc tccaatggct 531301 aaactcacga tgaatagaat ggggtattta ctatcaggca aatgctgtgt aatggcgttg 531361 atccccagtg cgaccgcagc gaatcccatt gcctgcatca aaatatcctg gtattcatct 531421 ttaatgcctt ttttgaatat ccccccgatt atgcttcctg caatgatcat cactgtgtta 531481 aaaatcgttc caaacataag ctttctcctc caaaaatcat tcctgcataa aaaataaacc 531541 ctctagttag tagagagtca agggagatca aaacatattc atgagattat ttgatgggca 531601 gcaggatttc agtcacgtaa ttatctaggt tattcgtaat gccataatca atgagtgtga 531661 tttcgattga gtcccctgct acctcataat gatgttcttt catatatgcc agtaattttt 531721 tgtagtatgg ttcggcttct ggatgtgacc ctttaaacct aatttgcaga tattctcttg 531781 aaggaaagat gatttctgaa gaagtttttt cattttcatc ttcaagaatc ataaatatac 531841 tggaatattt gtcaaactgt tttgctttca catttgctgc agaaatggat aaaccaatct 531901 tgcctatgaa tatatcttcg tttacattca ggtgggttct caattcagct aacgaatgtt 531961 cgatatcatg gccgagaaca tattcatgct gcaaataggc cacacgcatt gcgggaagtt 532021 tgatttttga aatttgatgt aacggcatgt taacggcatc ttctatatgt gtgatgcgtc 532081 gggagatctt tcgttcaatg cgttccaatt ctttcttctt gcgatcaatt tcaacctgct 532141 ggctttttag taaatgaaga agagtgtttg tattttgaga gttataaaaa tcaagaagct 532201 tattgattgg caggcctagg gccctcaaat acttgatggt atccagccgc tcaaactgtt 532261 gggtagaata atatctatag ttcgtttgct catctttata ttccggtttc aaaaggccga 532321 tttcatcata ataccgaaga gcagagattt tcacattgaa taactttgac acttctccaa 532381 tcgaaaaaaa ttccttcatt ctaacaacct ttctgtccta tgattgatat acacacatta 532441 tatagtacgg cgagtactaa aggtaaagtt tgcagcataa agaaaaaact ccttctaaaa 532501 aggagctttt cattcttcga aataaggatt tacatggatg agcacttctt ctacatctga 532561 aaactgtctt ttgatttcat ttcgaatttc gcgggcaatg tcgtgtccct gcttaattgt 532621 caaatcatga tccaaagata aacggacatc aagcaattta tagtggccat gttctcgcgc 532681 gcggattcta tcaattcgtt ttacctgatc acattgaaaa ataacagctt tatattcctc 532741 tatcagctcg ggatcaacac tcttttccat gagcacatca acagacggcc tgattaattc 532801 cattgaaatc ttaaaaatga ggtaagcaac gattgcactg gcaatggcat cggcgtacaa 532861 cagataggac catccacggc tgtttccgat gatagccaac aggacgccga taaaagcggc 532921 aagagaggca acgatatcgc ctttatgatc gtacgcaatc gctataatcg ctttgctgtt 532981 ccattttttc ccttgcttta tagaataacg atataagatt tccttagcca cgtacgaaat 533041 cagagccgca aacaatgcgc tgtattgggg aacgcttggc cctttaacaa aggacagaat 533101 cgcttctatg aggatataaa cggatacgat cactaagata attcctacaa tcgcctcact 533161 aatgacttca gcttttccgt gaccaaaagg atggtcttga tcgggcggtt tattggaaat 533221 tccgatcact gccaagactg caatcgaagc aacgacatct gccgcggaat gtattccgtc 533281 tgcaaacacg gcttcactat cgcctaccag cccaaaaaag acctttcctg ccattaagat 533341 cagattggcg atcaatgcaa tcaaagcaac ttttctgctt atttgttctc tttcacttgc 533401 cattttttcc tcctataaaa ctgcacaaaa aaataggagt gctctatata cgctctccgt 533461 atcctttcct gtgtaatcac tttgtttatc ataccaattc aatttcgagt gggtctatag 533521 caacgttgtt tcctgtttac taataaataa ggtgacagaa aaaaagttgg agctatgcta 533581 aaaaggtcat acagcaaaca aatgagttct tatgtaacaa cagtgatgat tcgctattaa 533641 aatgctgccg tcagtgaaaa atttccacct aattttcaaa aacctattga catgagaaga 533701 tctgtatttt actattatct catattcaag atattttaat ttgagatatt tggtcggaaa 533761 gatcagcgat caagcgcaac tctaagtgtt caatcgttgt cagttctttt acacaatatt 533821 caatatgatt ttttataaca taatatctcg aattcgagat aaaagggagt gtagcgtaat 533881 ggctgaattt actcatttag tcaatgaaag acgatctgca agcaattttc tttcaggtca 533941 tccaatcaca aaagaagatc tcaatgagat gtttgaattg gttgcattgg caccatcggc 534001 ttttaatttg cagcatacaa aatatgtgac ggttcttgac caggacgtaa aggaaaagct 534061 gaagcaggcc gcaaacggac aatataaagt ggttagctct tctgcggttc tcttggtatt 534121 aggggataag caggcatatc aacaagcggc cgatatctat gaaggtttaa aggtattggg 534181 gatattaaat aagcaagagt atgaccacat ggtgcaagac accgtttcgt tttatgaaaa 534241 caggggagaa caatttaaga gagatgaggc gataaggaat gcttcacttt ctgcgatgat 534301 gtttatgctg agtgctaagg aaaaaggctg ggatacctgc ccgatgatcg gctttgatgc 534361 ggaagccgta aaacggattt tgaacataga cgaccaattt gaggttgtca tgatgattac 534421 gattggaaaa gaaaaaacag agagcagaag accgcgcggc taccggaagc ctgtgaatga 534481 gtttgttgag tatatgtaaa aggagcggat aaaaatggct aaaaaaacga tgggaattca 534541 tcatattaca gcgattgtcg gtcaccctca agagaacaca gatttttacg caggagtgct 534601 tgggcttcgt ttggtcaagc aaactgtcaa ttttgatgac ccaggtacgt atcatcttta 534661 ttttgggaat gaaggcggga agccgggaac aatcattacc ttctttccgt gggccggagc 534721 ccgccaaggc gtcattggag acggtcaagt tggcgtgact tcgtatgtcg tgccgaaagg 534781 ggctatggca ttttgggaaa agagactaga aaagttcaac gttccctaca ccaaaatcga 534841 gcgctttggg gaacaatatg tagaatttga tgatcctcat ggactgcact tagaaatcgt 534901 ggaaagagaa gaaggagagg ctaatacgtg gactttcgga gaagtaacgc ccgatgttgc 534961 cattaaaggt tttgggggtg caaccctatt atcagagcag cctgacaaaa ccgctgacct 535021 tttagaaaac atcatggggc tggagcgagt cggcaaagaa ggagacttcg ttcgttatcg 535081 ttccgccggt gatatcggaa atgtgattga ccttaagtta acgcctattg gccgcgggca 535141 aatgggggcc ggaacggtgc atcacatcgc ttggcgggct aacgatgatg aagatcagtt 535201 agattggcaa agatatattg cttcccacgg atatggtgta actcctgttc gggatagaaa 535261 ctactttaat gccatttact tcagggaaca cggggaaatc ctgtttgaaa tcgcaactga 535321 tcccccaggc tttgcacatg atgaaacaca ggaaacaatg ggcgaaaaac tgatgctgcc 535381 tgtgcaatat gaaccgcatc gcacacaaat tgaacaaggg ctgctgccgt ttgaagtaag 535441 agagttagat tgatttgaca cataaaaaat aaagaaacat atattcaatt gatgattgct 535501 ggatggtact gtcagcaaag aatcagataa aatcaaagat gaggagagat acaaatggaa 535561 gatgcaggac tgttgcttat tcgtataatg attggtgtgg tgtttttgtt ttatggcaca 535621 caaaaattat tcggctggtt tggcggatac gggattaaag gaaccggaca atggttcgaa 535681 tcaattgggg tgaaaccagg aaacgttgcg gccgctctat caggtcttgg ggagttagta 535741 agcggaattc tatttatttt aggcgtattc ctcccgcttg gagctgctat cataacaatc 535801 atcatgttag gtgctatcgt aaaagtccat ggagcgaaag gttttgcgaa tggcgccgga 535861 ggttttgaat ataacctggt gctcattgca gtttccatag gggttgcact catcggttca 535921 ggagcttacg ctttgcattt ttaatacgaa agtatgtaag aacagttgct gcttgtcagt 535981 aactgttctt ttattttcac attttcggca agcttgcagg tactctgcaa agcaaaaaag 536041 cggatatcat aaatataaat ctgtatagtg aatgatacgt attgatgagc ttggtcatga 536101 aaaacagacc tatttgaagg agtaaatgga tgaaagagat gacaggatta cattcattag 536161 tttctataga aaactttatc aaacagcaca aattcagttt tatttatata tcaaggcctg 536221 gctgtacagt atgtcacgca gttctgcccc agctcagaat agtattggat cagtttccaa 536281 acatcaaatt ggggcatatc aatgctgacg atgtagcaga ggtcgccggc agattttcag 536341 ttttcaccgt tcctgtgctt cttttgttca ttgatgggac tgagtttcta agagaagccc 536401 gttttgttca ttttgaacag cttgaacaaa agctgaaaag ggtttatcga ttatatgaag 536461 gcgaataaag gaataaggca aaaaaagaac tcaaatgagt tcttttttta ttcttcacta 536521 ggcgaagaag ggttatcaac ctgcccttga tcacttgtat cattatcaca acttgctgaa 536581 ataataattg aatgagaagg agagtaatct cctaatgtga aattcactcc gtaatttttg 536641 ctgttcgcag tatggctgtt ttgcaagttt tgtccgatat ctgtattggc gttttgtgtc 536701 attccattta tcgtgagatt tgagatgttg atttgagatc gcatgcttca aaaactcctt 536761 tcactcagaa gtagctgtca taaaggacgc tggcagtcta tttacttcta tgatattgcg 536821 tttttatatc attgcatcaa cataatggta aaaataatag cgagtgaatg atcatctttt 536881 gaagatgatc aacctatcag cagaaataaa gccgcctgat aaagaggcgg cagatcgtta 536941 tatgtcatct atgaatttga tgtatcgttt ttcgtttgcc tgaaggataa gatagtcgtt 537001 tttaatgatg agtaggagcc tatagcagcg tagccataaa accagcccat aaatacgcca 537061 gaaaagaggc tgtgtcgatg gcttatgaaa acagaaatga caaggcctgt tattaaggca 537121 actgacggta caaaagtttt ggggattttc aataatattt tgaggatttg ggttatcaat 537181 atgatgattg gaacagctat cacagcatcc caaaagttcg tgtgaataat tggaaaagcc 537241 atacggcacc tcatgaagtg tttatttctt aatttttacg ctaaaagctt ggaaagcagc 537301 tcttggatcg catatgttac attttgggct tgattggcgg agcttgtttg gcttaaagca 537361 ttggattcaa aaaccaaacc tgtattactc ccaccggaac cctctgttgt tttagacaca 537421 gagaacgggc tgatggaaac tgcaaatccg ttattaaaaa cgctgttccc ggatatcgaa 537481 tgaatataaa ctgggaattt catcattcat ctctcctctc tgttatgact gtttatacaa 537541 tatggtgtgt gagcagcagt tgcttaaaca aaacggcaaa aactttcagt aagagacaaa 537601 aacctgcaaa atgccacaag cgccttttgt taatgcagct ttttagggac gtttttttta 537661 ttttttttgc caacttcatc aaaaatattc tgattgccag actgggcttg tccgtcctta 537721 tttatgaaat cggggtgaat gagttttttc agatccctga ctgttaaagg cttggcgtca 537781 tcagttaatt ctattcctaa ttgcccgttt gcctctaatg tcgcaatttt gacatcttgt 537841 atagccgtaa cgccgtgaag ccttagctgc atttcaagct ggtcagctgt aagtctcatc 537901 ttctttaagt tttcgatatg aagctgtccg ttttcaatga cgatttttgc ttttccggtt 537961 aacatctttt caatggtgtt cgatttcatt tggatccatt ccataacgat gagtgtgctt 538021 gtgaaaattg ccgctgcaat taatgttttg aagaggctgt actcgatgat tggctgaacg 538081 ataatagttc cgatcgaaat catgacaacc gtttgagtcg acgtcatttg tgcgattgat 538141 ttccttcctg aaattctcag caaaatgacc ccggctacaa tgagaacaag agattcccaa 538201 gtgaaattca tgctaccacc tgaccaatga tgaattagat ttgtcatggg attggctttt 538261 cttccggcca atcgcaattt aatatatccg aaaggcagtc ggttcattct gtcctgaacc 538321 gaacaatatt tttggtatag atggatatat taagccaaac aatgatagca acaggagttt 538381 tttggccgaa acaatctggg aagcggggag cgccataaca tgattgaact tgaagttgtc 538441 attagaacgg ttgccagctt tggcttgctg ttaatcgcag aacgaatttt aggcaaacag 538501 acaatctctc aaatgacgat ttttgatttt attgcggcga tcacactagg ggcgattgct 538561 gccggattag cttacaatac ttcaataaaa ccgcacaata tggccatttc gtttagtatt 538621 tttgtgctaa ccatttttct aatttcgttt ctgtcgataa agaacaggaa gctgaggaaa 538681 ttttttgccg gagatccaac agtgctgatt caaaacggga agatacttga atcaaatatg 538741 aggaaaatgc gttacacact tgattattta aatcagcaat tacgggaaaa agaaatattt 538801 aatatcgaag aagttctttt tgccattctt gaaacgaatg gtcagctgac tgtgttaaga 538861 aaaccgcaat tccggcatgt gaccaaacag gatttaatga ttgcggtaaa ccaagaacaa 538921 aggcttccga tagaacttat tatggacgga gaaatcattg agaataattt aaagcagaat 538981 cgtttgacgg aatcctggct tttggaagaa ttgcgaaaaa gagacataaa ggtgaaagag 539041 accgtgtacg cagtgctgct gggtaatggg gatatttatg tggatcaata taaagaccat 539101 atatcagtcc ctatggataa ggaatgaagg aacaatcaat cttaaagccc cttattgaac 539161 gcaacggttt caacttgtct tgggtacgaa atatgcagaa gcccgtttaa cagctgaatc 539221 tgtaacaaat gagtttcagc ggcttcggga agctgaatga ttcgctcaat ttctccgtaa 539281 taccgttcac gcagcacttc catttcggct ggaaaaacag gcgtgatcgt tcctttgatc 539341 agcagctggg ttttagacag taaacggatc gttaattctt cctcatacac accgggcatt 539401 tccacaatga taaaattata ttcctcatct tgataaaagt cgtaaacaaa cgtagaagct 539461 tcggaatcaa aaaaatgttc cggggcttta tatttgagca catttgtcca aaagtcactt 539521 tgtttatatt cattcgtaat ctcaagccac tttcgaattt tttcgaaatc catatgagat 539581 tctccttaaa tttgatttga aatcggcgca gaagggtttc cgatttggtc ttggtcacta 539641 acgtctgaat caatatttcc agtgtttaaa agtgaagacg taggcgaaag atcccctaag 539701 gaaaagtttg ctccaaaata tttgctgttc gcagtatggc tgttgtgcac agtcggaccg 539761 acatctatat ttccgttttg cgtgacgccg ttgatcttaa tatttgcgat attaatttga 539821 tatggcatag acgaaacccc tttaatctaa aattggcggt ggtgcaatcg gaggagcatt 539881 aacgttggat gtatcagagt tgccgataga tgtctggtca tttacatcag gatcgtttaa 539941 gaagttttcc attacggatt ctgtaggtga tgtatcaccg aaagaagagt tggtcccttg 540001 agatttttga ttgttggtag ggctgttata agcagcttcg cctattgtaa ttgaaccatt 540061 gcccgaaata ctgttgatct tcaaataata taggttgatt actgtagacg gcatcccatc 540121 acacccttcc atctttctgt acagtacatt atgcgccgct gcacccaatt gttccttgca 540181 tttacgggca aaactctatc tggccccgga gtgatgctca attatcagtg aatgaaaagc 540241 cattgatata ggaatcaatg aattgattca gttattcgaa atgcatgaga ccttttaata 540301 aaggaagctg gcaaacagga tcagtttgaa ataattgaca atgaagctaa tgccatgaaa 540361 taatactcgt gagtaacatt actcgtgggt attatttttg gggtggtcct agttgaaaag 540421 taaaggagta gaaagccgaa aacgattact taaagctgcc gctaatgaat tttcggttcg 540481 gggattccat gacgcgaagg taagtgaaat tgtgaaaaaa gctgggttca cgcagccttc 540541 attttacctg tactttcaaa gcaaagaagc catctttgcc gagttaataa ccgattttca 540601 ctctcgagtc agaaagctga cagagtcact tcttctggaa aacggattaa acacggagga 540661 tgtgtcaaaa cgggtactgc tagctgtaga gactgttttt caatttttgg atgaggacaa 540721 ggatttaacc aagatcggct tttttctcaa cccggaagca aaacaaatga aaaaagactt 540781 ggcgatggtt ttgaaagaga acttagaagc agaacagcgg cttggctatt ttcactctga 540841 actggatatg gaaactgtcg ctgagtgttt ggtcggcatg attgaacatt taaccgaatc 540901 atttttgtta accggaatca aagatccggc aagcctcgca gcagaggttg tgaatctttt 540961 aatttacggg atgcttccga aagggaatga tgtaagatga tatctattat gatgaaagtc 541021 agtttggcag tttttatgct tgcgggaggc atcataaagg taagccgcgt tccctttcaa 541081 gttgagcatt ggcggcatta tcaatatcca ttatggtttc tgactgttac tggcattctt 541141 gaaatagccg gggcacttgc tatgacagcg ggaatttgga atcggtatgc agcaattgga 541201 gcaggtgttc tgtttgtcgt tctcatggcg ggagcaattc atgcgcatat gtttcgagca 541261 agacaatctg tcatcatggc gatacaagcg atgatttgtt tgattgtttc aatcatgatc 541321 atcatgggga gttacacgta agcttttcac taatgtttaa gaacaagccc atttgcagga 541381 aatctccttt tcttatcgaa taatagaaag tccaggaatt aactgaatca gtaaaataga 541441 gctccatttc tgtgttattc gtccggcatc agctgggctt tttttataaa ggaggaatac 541501 aggatggcat tcactttgga agacatgact gaggaagagt tcgaagcctt tcgcgggatg 541561 tccgtgcaaa attttgcgaa acaaaacata acgtcaggaa cttggacgga aaaagaggca 541621 tttgagaaat cggagcaggc atatgagaac atgattccga atgggcgaga cagcagcaat 541681 cattattttt ggaacatcac aaatgaccaa ggagaaagaa tgggctggct ctggctgtat 541741 gctgatccat tacatccgca aaaggaagcg tttatctatt cctttggatt gtatgaagcc 541801 tttcgcggaa aaggacttgc tcaattggcg cttcaaacgc ttgatgaaag agcaagagag 541861 cttggtgcgg aaaggctggc tctacatgta tttgcacaca acgagacagc cgtctatctt 541921 tatcagaaga tgggctatgc catgaccaat atacgtatgc ggaaacagct atgctgaaaa 541981 gccgcttacg ttacccaaat acaacatgcc tatctggaag cggtggcagg gtactataag 542041 tcatcattag aaagattaag gtcatgggag gcttgaacat ataaagaaaa aggacaacag 542101 ctgttgtcct tttcaatgcc gcttgaactt tctccctcag tcttttttgt cttgatgatc 542161 cagctctttt attcgtttcg taagctcatt gaaagcctga tcaagctcct tatacccttt 542221 atcatttggc gtcataaaac tgagctttcc cagcacttct tgtctttctg tctcaagctt 542281 taaccgaagc tcctcccgct catttctttc tgaaggaacg tcgtttaact gcttttcgat 542341 gccgttgttt gagatgacga gtttactgtt tgttgttttt tcgagaaagt atcggtcatg 542401 tgaaaccgcc agcaatgtgc cgctgtattg tgacagtgtt tcttccagct gttcgcgtga 542461 cggcaggtcg agatggtttg tcggctcatc taaaatcagc acgtcttttt cctccagaat 542521 atatgccatc agcttgatct ttacacgctc acccatactc atatgcttga tcggttcagt 542581 ccattgggcg gctgtaaaac ctaagtgcct catcagattt tgaacgtgcc cccttgcttt 542641 gaatgtttca ttctcaaata actcttccgg tgtttgttct aaaggcaaat caaacacctc 542701 ctgcgttaaa tagccgatgt ttgcggacgg cgacacccat acacttcctt ctgctgtttc 542761 ctgtcccaga atgatgttca gtaatgtcgt ttttccgctg ccattggggc ctatgatcgc 542821 aaccttttcg ccgtgctgaa ttgtaaagtt tgcgttttta aagagagtcc tttctccaaa 542881 cgcttttgtt acattctgaa cttctaaaaa acgttttcct gttttgtggg ttgtatcgat 542941 tgaaaagcgg actgtatatt ctggggtaac gggttccgcc tttgcttttt caagctcttt 543001 ttcaagccgc ttctgcttgg attttatctg ggcatccgta cgcttcgctt ttacccggtg 543061 atattcttta aacccttcct ttttcgtcga ttgagcatgg gctttttccg accaagaagc 543121 gagcccattc atttgtgctt caatccgttc aaccattttt tgctgctttt catattcacg 543181 ctgctgggtg agtcttttct tctcccggaa cttcatatac ccggagtaat tccctttgaa 543241 ttcaatcagc gtctgatcct caagcgacca tatttttgtt gcggcttcgt ctaaaaaata 543301 tcgatcgtga gaaacgagaa tcacagtgcc gttataatgt ttcagctgtt ggatgagaaa 543361 ttgcaagctt ttttcatcaa ggtggtttgt cggttcatct aacagcagca gatctgcatc 543421 ctctgatagt cctttcgcca gccgcgcttt cagtttttca ccgccgctta actgatgaaa 543481 atcacgaaga ggcacatgcc atttctccag taacttcttt tcggcaggtg tctgatccgc 543541 aaaggaatac gccgcggttt cctgttcaac caaagccagt tttatatcct tccgaaggat 543601 ttgaccctgt gcaggggcta agtcattgtg aatgaggtgc agcaacgtag atttcccagc 543661 gccgtttttg ccgataatcc caatgatatc tccttgctga acactggcgt ttacatgttt 543721 aaaaacagtt tgatccttta cttcatagct aacgtttgtt aatgttacga tctctttcat 543781 ccatatccct cgctttaaag ggagaataaa aaaatcctcc caaatgtgtt ggaaggatta 543841 gccgtgcctg tgcatgatca aataagctat tttttataaa tagcagtgtc gtatatatag 543901 aaaatgggca gactaatcct attttttgat ttgaaatatt gatttcaaac ggtaaaaata 543961 agattagtta atcattgtcc acccatcatc ccttcttgtt ttgattacaa acactatagc 544021 atacctttaa attcaaaagc aaaggtcatt ttcatcaaaa aaactcctgc tctcattttt 544081 gaggcaggag ttttgagtct tattgatgct tcgcttttct cactttataa atcacaatca 544141 gcaaaataaa ccaaaccggt gtgacaaata aggaaacacg agtatcctgt gccagtgcca 544201 gcacaaccag aacaaacgcc aggaacgcaa gaatcaggta atttgtaaac ggataaagcg 544261 gaagcttaaa cttgtttgtt ttcgctaatt caggtcttgt tttgcggtat ttcatatggc 544321 agatgaccgt aatcccccaa atgtagataa agcatacggt tgaaatactt gtgatcaggg 544381 tgaatacgcc ttctggcatg atgtagttta acgtaacacc gattaaaatc acgatagctg 544441 aaaagaataa agcatttcta ggcactttac gctgagtcag tttcgccatt gactcaggcg 544501 cattgtgatc tttcgccagg gaatagacca tacggcttgt actgaataca gcgctgttgc 544561 atgctgaagc agcggatgtc aacacaacaa agttgataat acttgcagcc ccgacgatgc 544621 caacagcgac aaatacttgt acgaatgggc tttcgctggg attgatgata tcccaaggat 544681 agatgctcat aatcacgaga agagccccga tataaaaaag cagcacacgg acaggaatat 544741 tgttgatcgc cttagggatt actttttcag ggttttctgt ttcaccggcc gtaagcccga 544801 caagctcaat gccgacaaaa gcaaacacaa ccatctggaa cgagaggata aacccgtgca 544861 tgccattcgg gaacaggcct ccgtggctcc agaggtttgt gaagctggac actcctgagc 544921 ttgtggaaaa gcctttgaaa atcatcacaa ggccaatgac gattaacgcc aaaatggcaa 544981 tgactttaat caaagcgaac caaaattcta attctccaaa aagcttgact gtcgccagat 545041 tcataatcag taaaataata agagcgatta agccaggcac ccattgcggc acacccggga 545101 gccaatattg agtgtagagc ccgactgctg tcagatcagc catcgcaatg gaaatccagc 545161 agaaccaata tgtccagccg gtgataaaag ctgccatatc gcctaggtag tcttgtacaa 545221 aatccacaaa agagtgatag ttcaagtttg ataacagcag ttcacccagc gatctcataa 545281 ttaaaaagca aatgatccct gtgatcatat aagcaaataa aatcgaaggt ccggcaaaat 545341 gaatcgattt gcccgagccg agaaataagc ctgtcccaat ggctccgccg atggcgatga 545401 gctggatatg cctgtttttc aagcctctct gcaacgtttg ctgatttata ttgtctttcg 545461 tcatgtcgtc tgtcacttta tgtgttcctc cattgaaaat tgtttattga gtcagcaatc 545521 tatttttaat gattattata acactaaaat ttctatcttt tttactaaaa aaggattgat 545581 gaaaagaatt ttaatgtgat ttggactatt tcccgaaaaa agcggctcca tttagggagc 545641 cgctttttta tgctttttca gtttttgtca taaacaggta gagcccgtaa tctgtcggtg 545701 cggatgcgta gcctgcctgc cgcagcattg ctgtgatatt gccgcggtgg tatgtcccgt 545761 gattgacaac gtggggaagc agttcggaaa cagttgtttt catgattccg cttgagggat 545821 tttgaatctg gagtggctta ttgagctgtt ctttttgctg taaaaatagt atatagcgct 545881 cggataacct cagaaaaagg tcttccattt cctctatttc tttagcctct gtctgttctt 545941 taagctgttc agctaaagcc aacgcatcgc tcaaggtttt gccggaaaac acttcaatcc 546001 agccgagatc agaaagataa acatgagaca atacatggga tattgacgga aacacgcttt 546061 gaatttcttg atggtatatc tcttttggaa gctcttttaa tcggttgaat atttgttgat 546121 tggcccagac gttatattca tacaatttga atgcaaaatc tgacatgtta aaattccccc 546181 tttcgtgtgt atagctttca ttatacacga acatgagttc ttatgtagag tgctcgaaaa 546241 taaaatttgt tgacatatat agtttagagg aataaactaa ttgacattga acataaagtt 546301 tagcggggta aactataatg cgtctgatta gagctcattt cataaattct tgttttttgc 546361 agcacacctg tcgactcaag aagcaggtta tccagcaggt cagtaattaa gtttccgtgg 546421 ttatacaccc acgacccgtt ccacggattg ccccctgcat caacaggaag ggaactttgc 546481 gctccaataa tataatgatg aggattagca tgtttaaccg cttcatcaag tggcgcttga 546541 tctgtacctt gactgccgac accttcaccg cctgattcat ctaataaagc attgattgtg 546601 ttttgaacca gttcaacgtg ggcaatctcc tctaaaaaaa tgccgcgaag cagatcgcgg 546661 tactgtttct gctttcctct gaaattagag ctttggaaaa aaactgcatc attgtacgca 546721 tttctccgta atgaccgcct aatatctcct gcaggacctt agcagctgcc gggtctggct 546781 tgtccggttt aatgatatta atcagttcct ctttgtagta atacataaca cgcctcattt 546841 cttcttaaga gattttctta tattatttgt aagatgagat aaaatatata catgataagc 546901 atgggaaggc gtgaaagaag aaaataaaaa aatacaggaa aagtgttgac caaataaaac 546961 aggcatggta tattattaaa cgtcgctgat gaacagcgtg aaacaaaaca gaaaaacaaa 547021 aaagttttcc taaggtgttt acaagatttt aaaaatgtgt ataataagaa aagtcgaatt 547081 gaaaaagatt cgaaaaaaca ttaaaaaact tcttgacttc aacatcaaat gatagtatga 547141 tagttaagtc gctcaataag cgcccgtagc tcaattggat agagcgtttg actacggatc 547201 aaaaggttag gggttcgact cctctcgggc gcgccatata agataccacg cgggtgtagt 547261 ttagtggtaa aacctcagcc ttccaagctg atgtcgtgag ttcgattctc atcacccgct 547321 ccattattga atgatctttg aaaactaaac aagacaaaac gtacctgtta attcagtttt 547381 tgaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga tgcaggtcac 547441 acaggtgtca ccgcgggatg cggtggactt aacctgtgat ccatttatcg gagagtttga 547501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cgaacagatg 547561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 547621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 547681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 547741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 547801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 547861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 547921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 547981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 548041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 548101 gcccccggct caaccgggga gggtcattgg aaactgggaa acttgagtgc agaagaggag 548161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 548221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 548281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 548341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 548401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 548461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 548521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 548581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 548641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 548701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 548761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 548821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 548881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 548941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 549001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 549061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 549121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag taatacaaga 549181 tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg gatgccttgg 549241 cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc tgtaagcaag 549301 ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt ggtatccata 549361 tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta agtacccgga 549421 ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat tagcccaaac 549481 caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa ggaacgaggt 549541 agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt caaaacttcg 549601 ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg gaatccggga 549661 ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt accgtgaggg 549721 aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg tgcctacaag 549781 tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg gcgagttacg 549841 atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc tgaatagggc 549901 gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca gggtgaagtt 549961 caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg gatgaggtgt 550021 gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga aatagcttta 550081 gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag gggcccctac 550141 cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg agtcagactg 550201 cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta aggtcccaaa 550261 gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt tggcttagaa 550321 gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg cgccgaaaat 550381 gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt ggtaggagag 550441 cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga agtgagaatg 550501 ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta aggtttcctg 550561 aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa ggcgtaggcg 550621 atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat ggggggacgc 550681 aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg ctgggaaata 550741 ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag tagcgaagtt 550801 cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg taccgcaaac 550861 cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg ttaaggaact 550921 cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc aagcccgaga 550981 gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc tgcgaagccg 551041 taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag gagcgcttag 551101 cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat aacggtccta 551161 aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca acgatctggg 551221 cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca ggttacccgc 551281 gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg ttggtacagc 551341 ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg aggcatcggt 551401 gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg cggggagaca 551461 gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa 551521 aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag ggagcttgac 551581 tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg tggttccgca 551641 tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct tatctccccc 551701 aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc atcctggggc 551761 tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga gctgggttca 551821 gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt gagaggagct 551881 gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg ttctgccaag 551941 ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta agcatgaagc 552001 ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa gatgatcagg 552061 ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact aatcgatcga 552121 ggacttaacc atatttttga atgatgtcac acctgttatc tagttttgag agaacactct 552181 caatttgttt ggtggcgata gcgaagaggt cacacccgtt cccataccga acacggaagt 552241 taagctcttc agcgccgatg gtagtcgggg gtttccccct gtgagagtag gacgccgcca 552301 agcattactt ttatcatcgc ggggtggagc agttcggtag ctcgtcgggc tcataacccg 552361 aaggtcgcag gttcaaatcc tgcccccgca accaaatata tggttaaata aggagtgccc 552421 taagggtgca accaaaataa tcctatacaa atatggtccg gtagttcagt tggttagaat 552481 gcctgcctgt cacgcaggag gtcgcgggtt cgagtcccgt ccggaccgcc attaatgtaa 552541 acgaaacgat catgttttcg ttttttttgt gttttctttt actgtatctt ctgcttggtg 552601 tcatagccaa gctttcttta tatcgggaac atcttggata ttccagcaaa attcgataaa 552661 ctaggaagag cacaaatagg cataagcagg gttgaaagga ggttttggtt catggatgaa 552721 tttgatttga tacatagcat tactccgcgg accattcacc attcttccgt tgatgtagga 552781 ataggtgatg atgcagcgct ctacactgcg aaacacggcg ttcaggaaat tgtttgtgtt 552841 gatactatgg tagaagacgt gcacttcaaa ttacactatt cctcacctga agatatcggg 552901 tacaaggcgt tagccgttaa tataagtgat attgccgcga tgggaggcat tcctaagttt 552961 tatctggtat cacttgcggt accttcaaaa tggactgaat ctgaaatcaa ggcgatgtat 553021 gaaggaatga atgaactggc gaaactatat catatggatc tgattggcgg cgatacagtt 553081 tctaccgctg acaaattagt cgttacagtc actgtaatcg gtgaaattga aaagggacag 553141 gcctgtttgc gcagcttggc aaaaccgaat gatattgtgt ttgtaaccgg tgaaatcggt 553201 tcttctgcag cagggctttc tttattgctg gaagagacta atcctcaaaa ctcatctgtg 553261 gaaacggatt actttatcca caggcataaa cggcctgagc caagagtaag cgtcggcaga 553321 ttatgctcga tttttaaacg ggcagcttta aatgatgtta gtgacggatt ggctagtgaa 553381 ctgaacgaga ttgcagaagc cagctgtgtt tcaattgaaa ttgttgaaag catgcttcca 553441 attcattctg atttgcctaa gcttcatcct aactggaaag aatgggcttt gtttggcggt 553501 gaggattttg agctgacagg gacggtttca aatgaggagt gggaagtgtt gaagcaggag 553561 tgcgcagcgc ttcatcttcc cattacaaag attggctatg tcagggaaaa aacaaaatct 553621 aaagtgatcc taaaaacaga tcaaacatca atgatcttag agaaaaaggg atataatcat 553681 tttaaataag acgggtgact cgtgtgaagc aattaaaatg gagaactgta aatccagaag 553741 aaacaaaagc aattgccaag ctgacggcag cgtttgctaa accgggagac gtcctgacat 553801 tagagggcga tttaggtgca ggaaaaacga cttttacgaa aggttttgca gaagggctgg 553861 gaattacacg tattgtaaac agtccgactt ttacaattat aaaagaatat aacgatggcg 553921 tacttcctct ttatcacatg gatgtgtata gaatggaaga tgaaagtgaa gatttgggac 553981 ttgatgaata ttttcacgga caaggtgtct gtctcgttga atgggctcat ttaattgaag 554041 aacagctgcc acaggagcga ctgcaaattg tcatcaaaag agctggtgat gatgagcggg 554101 aaattacctt tactgctgtc gggaatcggt atgaaatgct ttgtgaggag ttaagtagac 554161 atgacaatat tagcaattga tacatcaaat tatacattgg gcattgcgct gcttcgagaa 554221 gacactgtta tagcagaata cattacatat ttgaaaaaga accactctgt aagagcgatg 554281 cctgctgttc attcattgct gaatgattgt gatatggcac cgcaggacct ttctaaaatt 554341 gtcgttgcaa aaggccctgg ttcatacaca ggagtaagaa taggtgtgac gttggccaaa 554401 acacttgcct ggtctttaga cattccaata agtgctgtat caagtcttga gacgcttgcg 554461 gcaaatggcc ggcattttga cggtctgatc agcccaatct ttgatgctag acggggacag 554521 gtgtacacag gtctgtatca atataaaaat gggcttttag agcaagttgt tccagatcaa 554581 aatgtgatgc tggcagattg gctggagatg ctaaaagaaa aggaccgccc tgttttgttt 554641 ttaggccatg atacttctct tcacaagcag atgatcgagg atgtgcttgg aacaaaagga 554701 ttcattggaa ctgccgccca gcataacccg cgcccttcag aattggcttt tctcgggaag 554761 gaaaaggaag cagctgatgt tcatgggctt gtcccggatt acttgcggct ggcagaagct 554821 gaagcgaaat ggattgaaag tcaaaagtag ggtgatagga tgaaaacaaa agcagcggtc 554881 agaaatatgc ggcttgaaga tatagatcac gtatacgaaa tcgaagcatc ctcctttacg 554941 tctccttgga cgaaggattc gttttatcat gagctgctgg aaaatccgta tgctcattat 555001 ctcgtgattg aaaaggacgg ccatcttgct gggtattgcg ggatttggat tgtgatggac 555061 gatgcccaga ttacaaatat agcgataaaa ccagagtatc gcggccagtc tttaggagaa 555121 acgctttttc gctcagctgt tgaactgtgc aaagaaaaag acgcaaggcg gctttcgctt 555181 gaagtgaggg tttcgaatca tcctgctcaa ggcttatata agaaattcgg gatgcagccc 555241 ggcggaataa gaaagaacta ttatactgat aacggggaag atgcgttaat tatgtgggtg 555301 acgataaatg agtgagcaaa aagacatgta cgtattagga attgaaacaa gctgtgatga 555361 gactgctgca gctattgtga aaaacgggaa agagatcatt tcaaacgtag tagcctctca 555421 aattgaaagc cataagcgct tcggaggcgt tgttccggaa attgcttcaa gacatcatgt 555481 tgaacaaatc actttggtta tagaagaggc gtttcgcaaa gctggcatga cgtatagtga 555541 tattgatgcg attgcagtaa cagaaggtcc gggactggtg ggagcgcttc ttatcggagt 555601 gaatgccgct aaagcattga gctttgcata taacattccg ttagtaggcg ttcatcatat 555661 agccggtcat atatacgcga accgtcttgt agaagacatc gtgttcccgg cactggcatt 555721 ggtcgtttca ggaggccata cagaactggt ttatatgaag gaacatggat catttgaagt 555781 cattggggaa acccttgatg atgcggcagg agaagcctac gacaaagtgg cgcggacgat 555841 gggattgcca tatccgggtg gaccgcaaat tgacaagcta gctgaaaaag ggaatgacaa 555901 tattccgctt cctcgcgcat ggcttgaaga aggctcttac aacttcagct ttagcggatt 555961 gaagtctgcg gtgatcaata cgcttcataa tgcatcccaa aaagggcaag agattgctcc 556021 ggaagatttg tctgccagtt tccaaaatag tgtgatcgat gtcttggtaa ccaaaacggc 556081 gcgcgcggca aaggaatatg atgtcaaaca ggtcctttta gccggaggag tagctgcaaa 556141 cagaggcctc agagctgcat tagaaaagga atttgcccag catgaaggga ttacgcttgt 556201 cattcctcca ttagctttat gcacggataa tgctgcgatg attgctgctg ctggtacaat 556261 tgcttttgaa aaaggaattc gcggtgcata tgatatgaat ggccagcccg gccttgaatt 556321 gacttcttat caaagtctca cgagataata gcgtgagact ttttatctgt ttgttattaa 556381 cagacaattc acaatttatc cacatatctg tgagtaatta tagagatatt gatggataaa 556441 gggctgaggt cactgttaat aaagtggata aattcagaat attttgtgga tagtgtgtat 556501 aaagcgctta ctttgtttat ttattagggg atgttctgtg gataaaaagc acctctaaaa 556561 agaggtgctt gactttttta atcttcttct gtggatagtt cttcccattc ggacaaaaga 556621 gattccagct cctgattaag cttctcattg tctgcatgga tagcttgtac tttttcatga 556681 tcctgataga cttcagggtc acatagcaat tcatcattgc ggctgatgtt ctcctcaatg 556741 gtttgaacgg tggtttcaat ttcttcaatc cgacggagtc gttggcgctc tttctttttc 556801 cattcttttt cttcctcgta ggaacgtttg gagtcagact tcactgtagc tggcgtttta 556861 tcagtttcct cttgctgatt cattttctcc aattcaagct gctctgtttt tttctctgta 556921 taataatcgt aatctcccag atactcctct atatggcttg aagaaagctc caatactctt 556981 gtggcgattc tgttaataaa atatctgtca tgtgagacaa ataacagtgt gcctggataa 557041 tcaatcagcg cgttttcgag aacttctttg ctgtctaaat ccagatggtt cgtcggttca 557101 tcaaggatga gaaagttggc tttttgaagc atcagcttag ctagagccaa tcttgctttt 557161 tcgcctccgc tcagtgaatg aactggtttc agcacatcat ctccggagaa taagaaattt 557221 ccgagacacg ttctgatttc tttttctggg agcccggggt actcgtccca cagctcatca 557281 aggacacgtt tagaggaagt caactcagcc tgttcctggt cataatagcc gacactgaca 557341 tttgagccgt aagaaattgt tccctgatct ggttttaggg tgtctattaa tgttttcagc 557401 aatgtcgatt tacctattcc gttagggccg acaagcgcag cgctttctcc tcttgtgagc 557461 atgaatgaca cttctgttaa aagcggcggc tggttttcat agctgattgt gagatcctga 557521 acacgaagga cttcatttcc gctctgtttt gtaatatcaa aatgaaagtt tgcggatttt 557581 tcatcgccaa gcggttttga catgacatcc attcgctcaa gctgctttct gcggctttgc 557641 gcccttttgg tggtagaggc tctcgccaga tttcgatcta cgaagtcctg cagctttgca 557701 atctcgtcct gctgcttttc atacattttc agatcttttt catactgcgc ggctttttgg 557761 tcgagataag cgctgtagtt gccgtgatac tttttgcttt ctgctcttga tacctcgtat 557821 acctggttta ctactttgtc caaaaagtag cggtcatgcg aaacgatgag aatggcgcct 557881 gaatagcctt gtaaataatg ctcaagccag gtaagcgtat caatatccag atggtttgtc 557941 ggctcatcaa gaatgagcaa atcaggctgt gttaatagaa gcttacctaa agccagtctt 558001 gttttctggc ctccgctgag gctttgaacc tgtgtagaat cgtcaaaatg gctgaagccg 558061 agaccatgca gcacagatct aacatccgct tcatattgat aaccgccttt atctttgaat 558121 tcctgctgaa gacggtcgta ggttttcatg atgctttcta attcacccgg gtcagctgcc 558181 gccatttttt cttccatagc ccgcatttcc ttttccattg cttttaagtg gtcaaaaaca 558241 gtcagcagct cttcttttat ggtaagctta gaatccaagc cagtatgctg ggcgagatat 558301 cccattgtaa tatctttcgg tttaataatt tcgccctttt catacgaaag ctggcctgcg 558361 ataattttaa ggagcgtgga ttttccggcg ccatttcttc ctacaatggc gatgcgatca 558421 cgatttctga cttccagctt tatattgttt aaaatagtat cagcaccaaa tgatttggac 558481 agctgattaa cttgtaagat catcatatta tttcacctct gctataataa gttaagtgta 558541 gcttatgaac cagaagtcag caaacaatac attggccata taagacatag agaagaaaat 558601 agtgtatgat ctgtttaagg agcgttttaa tatgaatgga ttttctcatt ttaatgaaca 558661 gggcagagcc cagatggtgg atattagcga aaaatcttcg actgtccgta ctgcggcggc 558721 tgtttcaagc gtacacatga agaatgaagt gtacgagaaa atacaaagtc acgatatcgg 558781 caaaggagat gtactggctg tcgcacaggt ggcaggcatt atggccgcaa agcaaacgtc 558841 gaatatcatt ccgatgtgcc atccgctttc attgagcggg gtagatatat cgtttgactg 558901 gaaaataaaa gaagcagaag ttatacttca tataaaagca caggtcaaaa cgaaagggag 558961 tacaggtgtg gaaatggaag cgctcacttc tgcatcggtg tgcgctctta ccgtttacga 559021 tatgtgcaag gcccttgata agggaatggt catcggccct actttcttgc tggagaagac 559081 aggcgggaaa aacggtgact ttaaaagaga actatccgag tataatttgg aggaccaaaa 559141 atgaataagg atcaatcaaa aattccgcag gcgacggcga aacggctgcc gctttactat 559201 cgctttttaa agaatctgca tgcgtcagga aaacagcgtg tatcatccgc tgaactcagt 559261 gatgccgtaa aggttgattc tgccacgatt cggagggatt tttcctattt tggagctctt 559321 ggcaaaaaag gatacggata taatgtggat tatttgctgt cttttttccg gaaaacgctt 559381 gatcaggatg agatgacaga cgtcatcttg attggtgtcg ggaacttggg aacggcattt 559441 cttcactata atttcacaaa aaacaataac acaaaaattt ctatggcttt tgatataaat 559501 gagagtaaaa taggaactga ggtaggcggc gtgcccgtct ataaccttga tgaccttgaa 559561 caacacgtaa aagatgaatc agttgccatt cttacagtgc cagcagttgc cgctcaatcc 559621 attacagaca gattggtcgc attaggaatc aagggaatcc ttaattttac gccggcccgt 559681 ttgaatgtgc cggaacacat tcgaattcat catatagatt tagcagttga gcttcagtca 559741 ctggtttatt ttttgaagca ttattcagtt ttagaggaaa tcgaatagag ggaaaggagg 559801 agcccaaata tgccgatcgg tcctggaagc cttgctgtta tcgcaatcgt tgctctgatt 559861 atcttcggtc ccaaaaagct gcctgaattg gggaaagcag cgggagacac acttcgtgaa 559921 tttaaaaacg ctactaaagg attaacgagt gatgaagagg aaaaaaagaa agaagatcag 559981 taagttagga tgacacgaat gaaagtgaat caaatgtcgc tgctggagca tattgctgag 560041 cttcgaaaac ggttgctgat tgtagcgctg gcgtttgtcg ttttctttat tgctggattt 560101 tttttagcaa agccgattat tgtgtatctg caagaaacag atgaagcgaa gcagcttacg 560161 cttaacgcgt ttaacctgac agacccgctt tatgtgttta tgcaatttgc gtttatcatc 560221 ggcatagtct tgacctcgcc ggttattctt tatcagcttt gggcttttgt gagcccgggc 560281 ctctatgaga aagagcgcaa agtaacgctc agctacattc cggtctctat tttgctgttt 560341 ttagcgggct tatctttttc atattatatt ttatttcctt ttgttgttga ttttatgaag 560401 cggatttctc aggacttgaa tgtcaatcag gtgatcggaa ttaatgaata ttttcatttt 560461 cttctgcagc tgacgattcc gtttggactg ctgttccaaa tgccggtcat cctcatgttt 560521 ttgacaaggc tcggaattgt gacaccgatg ttcttggcga aaatcagaaa gtatgcgtat 560581 tttacgctgc tggtgatcgc agccctgatt acaccgcctg agcttctgtc ccatatgatg 560641 gtcacagtcc cgcttttgat tttatatgaa atcagtatcc ttatatcgaa ggccgcttat 560701 cggaaagcac agaaaagcag tgctgccgat cgggacgtgt cttctgggca ataataaaaa 560761 atccatttct catgcgagaa atggattttc tttatttttg gttctttttg attttaaatg 560821 aaaaggcgaa catcttaaaa gaaatgctga tgttgtaagc ggcgaacacc atcagcagga 560881 tggagtaaaa tgaccacatg ctgcctggcg agcttgcggc aagataagta aagatgcacc 560941 ctacggcaaa gtagatcatt ccccaaacta ccgggtttct cataaaaata atcctccaat 561001 aatcaattgc atttgtgtgc tctgctgttc aaggtaatta cgaacaggct caagctgcat 561061 gatgacgacg aatgtattca tcattaaatg ggcgaaaatc ggcacccata tccgttttgt 561121 tctcgcatat aaaaaggcaa aggtaaagcc cattgctgta tatagaagga gatgcttcaa 561181 atcagcgtga acaataccga agataaccga gctgatcagt cctgcgaaaa agaaattcgt 561241 tttttcgtac agcgcgccga aaatgatttt tctgaagatg atttcttcta atataggccc 561301 gacgatggaa gaaacgataa tcatgagcgg gactgcctga atgacatcca gaatcgcttg 561361 tgtattttct gattctcttc cgatgccaaa aacataatat tcaatagagc ctgctattcc 561421 ttgagagaaa agggcaatga aaaaaccggc tatcgcccaa aggatagaaa gtccgattga 561481 gtccttctgt ccgtttcgca gcgtttcttt cggaacggtt ctcagaatga gcagaacaac 561541 aacgagacag gcgataaagc tgataacgga ccataatcct tgtgcatgca gcatattttc 561601 atctgtaggc tgtcctccgg cataaccgaa tttaaataac aagggaatcg cgattaatgc 561661 ggaaaactgc atgatgatat atgtcaaaat aataaaccaa tactgttttc tcaaatggta 561721 tgtactcctt tgttaagtgg gtttcgttca tctacagcta ttgtaacata atcggtacgg 561781 gggtgaaaaa gctaacggaa aagggagcgg aaaagaatga tgtaagcgtg aaaaattttt 561841 tatcttatca cttgaaattg gaagggagat tctttattat aagaattgtg ttagcactct 561901 ttagtgctga gtgctaaaat tacatattca tactattgag gaggttattt cattgttaaa 561961 gccattaggt gatcgcgttg tcattgaact cgtagaatct gaagaaaaaa ctgccagcgg 562021 aattgtgttg ccggattctg caaaagaaaa accgcaagaa ggcaaaatcg tggcagctgg 562081 ttcaggtcgc gtgttagaaa gcggagagcg cgttgcttta gaagtaaaag agggcgaccg 562141 cattatcttc tcaaaatacg caggtactga agtgaaatac gaaggtactg aatacttaat 562201 cttacgtgaa agcgacattt tagctgttat cggctaattc ttaaataaac aatacttaaa 562261 acatttgagg aggtcttgta aacatggcaa aagaaattaa gtttagtgaa gaagctcgcc 562321 gcgcaatgct tcgcggtgtc gatgcacttg ctgatgctgt taaagtaact ttaggaccaa 562381 aaggacgcaa cgtggttcta gagaaaaaat tcggttctcc gttaatcaca aatgacggtg 562441 taacaatcgc taaagaaatc gagctagaag acgcgtttga aaacatgggt gctaagcttg 562501 ttgctgaagt agccagcaaa acaaacgacg ttgccggtga cggtacaaca actgcaacag 562561 ttcttgcgca agcaatgatc cgtgaaggcc ttaaaaacgt aacagcaggc gctaaccctg 562621 taggcgtgcg taaagggatg gaacaagctg tagcggttgc gatcgaaaac ttaaaagaaa 562681 tttctaagcc aatcgaaggc aaagagtcta tcgctcaggt tgctgcgatc tctgctgctg 562741 atgaggaagt cggaagcctt atcgctgaag caatggagcg cgtaggaaac gacggcgtta 562801 tcacaatcga agagtctaaa ggcttcacaa ctgagcttga agttgttgaa ggtatgcaat 562861 tcgaccgcgg atatgcgtct ccttacatgg taactgactc tgataagatg gaagcggttc 562921 ttgacaatcc ttacatctta atcacagaca aaaaaatcac aaacattcaa gaaatccttc 562981 ctgtgcttga gcaggttgtt cagcaaggca aaccattgct tctgatcgct gaggatgttg 563041 aaggcgaagc acttgctaca cttgttgtga acaaacttcg cggcacattc aacgcagtgg 563101 ctgttaaagc tcctggtttc ggtgatcgcc gtaaagcaat gcttgaagac atcgctgtcc 563161 ttactggcgg agaagtcatc acagaagatc ttggccttga cctgaaatct actcaaatcg 563221 ctcaattggg acgcgcttct aaagttgtcg ttactaaaga aaacacaaca atcgttgaag 563281 gcgctggcga aacagacaaa atttctgccc gtgtgactca aatccgcgct caagtggaag 563341 aaacaacttc tgaattcgac agagaaaaat tacaagagcg tcttgctaaa cttgctggcg 563401 gcgtagctgt catcaaagtc ggcgctgcga ctgaaactga gctgaaagag cgtaaacttc 563461 gcatcgaaga cgccttgaac tcaactcgcg cagctgttga agaaggcatc gtatccggtg 563521 gtggtacagc gcttgtaaac gtatataaca aagtcgctgc agttgaagct gaaggcgatg 563581 ctcaaacagg tatcaacatc gtgcttcgcg cgcttgaaga gccaatccgt caaatcgcac 563641 acaacgctgg ccttgaagga tctgtcatcg ttgagcgcct caaaaacgaa gaaatcggcg 563701 taggcttcaa cgctgcaact ggcgaatggg taaacatgat cgaaaaaggt atcgttgacc 563761 caacaaaagt tacacgctca gctcttcaaa acgctgcgtc tgtagctgca atgttcttaa 563821 caacagaagc tgttgtcgct gacaagccag aagaaaacgg tggcggcgca ggaatgcctg 563881 atatgggcgg catgggcggt atgggtggaa tgatgtaata aagggatatt aacccttata 563941 catcaatgtt ttaaccgtct taaaaaacta gacaaagcgt gaataaaaaa agagaaggtc 564001 tttcatcagt ttactaaact gttgggagac cttttctcca tattagcggt catatgagca 564061 taaatgtcca tcgtcgtatt tatgtccgaa tgaccaaatt gttgctggat ttctttaatg 564121 cctactcctg cctcaattag taaggaggta tgggtatgcc taaaagagtg gggggtgaca 564181 ttctttttat cccagctttt ttgagcagcc gtttaagtct agtctcaata acctttctta 564241 attgcggatg accatcctcc cgctcaaaaa taaatgatga gtcttgataa atcaatctat 564301 ttttaagctt aatttcattt tgataaattt tatttttttt tagtagattg acatcgtttc 564361 atcaattcga acgatatcaa cagatcctgt tgttttaggt gttagcaatt ggtatttttc 564421 aatttgattg ttaggggtgt atagggtctt tgtgacctgg cttatcattg aaatctgtcc 564481 attttaaagc aagaagttca ccaattctta ggtcggtcta ggcaagtacg gtaaagacca 564541 aatggtccat ttctagcccg tcagattgag cgagctttag aaaatgtgtc agcacctctt 564601 tttccaatgc tttgttgctt cttgggtaat tgaaaatccc cagttgggtt cattttaata 564661 atcccttgag ttttagcttt tcggaaaatc atacggccgc aggcatgaat acctcccaaa 564721 caattgtgac tgtattgctc gttcagttct aacgtgcggt cttcatacat ttttttgtgt 564781 tttgctaatc gggtattgac ccaatactgc gataaaatgc atcattttct tttcactggc 564841 ccgtacactg cttattttta ccccactccg gttgtaaatc ttaagccaac cttttgcaaa 564901 tgttttgaag ggcatatctg actccttaat aaaagtcccg ttgtcgtttt ggagttctac 564961 gtgacgggct gctactgggg cttctttctt tgttttaaat cttcctttgg atatttctag 565021 acgttttttg gttaaagggt caatgcctag tagatatgat aactccacgt cttaccgcat 565081 tgcttgagtt ttgccattta tttgtcccta actaattttt tttcatcaaa ttggtcttta 565141 agtgagttta ataatttttg tttctctcga ctggtcaata attgcccttc atatttcaaa 565201 agattggata aatttgagat ggaatcaatc ctgatggatg gtaccgtaga ctttaataag 565261 aaacgaaagg ccaactgcga cttcagttgg cctttcctat ttataataaa gaaattgagt 565321 gagattgctg acagaactac gtactactcg ttttctttag ttgcccttgc taatcgttca 565381 acctctcccc gaatcccaat cgcaggctcc cacgaatcaa tcaaacgaat cgccttctga 565441 ttagattcca ccgctttcgt tttctctcct ttacgataca acagctgcgc cattccgtag 565501 tgatagtaga tcagttcaac ttgattggcg ttatgtttgt catagagcat ttgctcaaag 565561 gcttcttccg ctttttcaaa ctgatcacat ttcacgtaag cgacacccag attgaaatag 565621 gcttctatcg ttttttcgcc gccgtatgtg gagctgattt catttgccgc ttcgtataat 565681 tgaatggctt ctacatgata acctctcgca aagcttaagt caccgcgaac caatagaact 565741 ctgtgttgaa tggtagggga aatcggttga ttttcgattt cgtttaaaat tgtctctgct 565801 ttttcctgtt gcccgtcttt taaaaacagc cttgctttga gtgcatgtcc ccaaaccttt 565861 agatcatagg catcgtgagc gtctgattgt tcaagaatct tcagcccggc ttctatttgc 565921 tgaagcgctc cgtctaaatc attgacttcc atcaatgccc agcctgaggt gtcgattcgg 565981 aagtacgctt ctcgtgtgtg ttggcctaag tgatgggcgg cgtcggccgc tttgcgtccg 566041 tattcgattc gcaggggcag gttgattctg cttagaaaat ggctaatgcg ggtgatgagt 566101 tcgattagga tttctttttg ttcagtttca cttgcccatt ggatgacctt taagatgttt 566161 ggccattctt gtttcatttg atctaagttc cgtcccagca ggtagctcca atagatagag 566221 ttgggctgtt cccgctttaa atgggtttcg gcataatcaa tataatagtg cgcccagcga 566281 ttgcgggctt ctttttcata ttcgtgctgt tcggacaagt gctgttctcc gtaagcgaca 566341 acggtttggt gcgctaagta ttgtgtcctg ccttggcttc gttccggctg aatcagcgca 566401 tatgaccgca tttgttccat agcgtaatga aaacggcggg cgtctaatcc ggctgctgcc 566461 gccaggcttt tttcatcagg cggcttgctg aaaaagcaaa gcgtctgcca gagctttcgc 566521 gtatcttcat tgcatctatc ccaggtgcgg ccaaagagga attcaaacaa ttccagcagt 566581 gagtagcctg cttttccaag ctcatgaatc agctgctgag cggggatgtc atcgtctgac 566641 atataggcaa tgctgagtgc catggctttc gggtttccgg cagtcgctga aatgaattcg 566701 tttttcaggt cagatgatag atgtaacagc tgctccagct tttcccgttt acgtgggagg 566761 ttgcatgttt gtaagcagtg atgcacttct tgttgaaaaa attcgtgggc atctgtttgg 566821 tcaagaccgc ttagctgaat ggctgtcatt tctccgaagc tttcccgata agtttgcttt 566881 acgttttccc gcgctgtaag gagaactttt acgccttgcg gaaggctggt gataaattca 566941 tgaatgtcac gttctgcagt atcaatgctg tcaacgatca gcaggatcgg tttttctcta 567001 gtgtaattgg ctaacgcatt gcggacgaca aaccgtttta cattgattga tttatcgatt 567061 tgttctttgc gtccgagctg ataggcgatc gtatttaaaa aatcgctaaa gcttaatcct 567121 ttccaatcag cgctgaccca gatgatgctg ttgaatgccg gccaaactga agtatcgtcg 567181 acacaggaat aggcggcttc aagagcaatt gtggtttttc ccatgccggc ccagccggtg 567241 attaaacaga ctggtgatgg agaaagcatc cattgccgta tcgcttccat atcaaagctg 567301 cgtccgataa agcgtccgga ccagcgtgag ggtaaattat gcgtgatggg ctgttctgta 567361 agcgcattcg tttcttggcc gggtctgtca tgaaacagcc gttttactac attttcaatt 567421 tcgccttcac tcggagcccc gaataatccg tcttttcgca gtattttcgc ttttttcaaa 567481 caggatgctg cccatacagg caatgcgggt ttgatgactg ggatagtggt ggcttccagc 567541 aagtcggtca accactcgat atccaagtcg gtcttttcga gaatgatcca gatcattccg 567601 aacagttttc cgtcgtcgat tcttccggga atgtagtttg cccccatctg tccgatccag 567661 cttttgatcg tgtttgggga gactcccagc tggagtgcga ttttatctat gtaagactgt 567721 cctgtttttt cattcttttt ccttctgact ttataatcag gatgaagttt tagcgttttg 567781 acgccaggtg ccagcatttg tgcaaattgt tttcggtttt caagttcagc cataagcctg 567841 cacctcctat tagtactatt ttatcaatcc agcgtttttt gtatatgaaa aaataaaagt 567901 acagtgccgc tgtcctttta tacagcagga aaggctgttg aacgtgttaa aaagcagata 567961 aaatgggggc agtaacagag aaaacaaaaa tgtatgcact tacattttat tttctaaaga 568021 aaggaacttg ccaaatgact cacacagtac ctcaaaacat gaaagcggct gttatgcaca 568081 acacaagaga gatcaaaatt gaaacattgc ctgtgcctga tatcaatcat gatgaagtgt 568141 tgattaaggt gatggctgtc ggaatttgcg gatctgatct gcattactat acaaatggcc 568201 gaataggcaa ctatgttgtg gaaaaaccat ttatccttgg gcatgaatgt gcgggtgaaa 568261 ttgccgctgt cggatcatct gtcgatcaat tcaaggtggg agaccgcgtc gctgtagagc 568321 cgggtgttac gtgcggacgc tgtgaggcgt gcaaagaagg acgctataat ctttgcccgg 568381 atgtacagtt tttggctaca ccgccggtag acggtgcgtt tgtccaatat attaaaatgc 568441 gtcaggactt tgttttttta atcccagact cactttctta tgaagaagct gctttgatcg 568501 agccgttttc tgtcggtatc catgcggcgg ccagaacgaa gctacagccc ggatcaacga 568561 ttgcgattat ggggatgggc cctgttgggt taatggctgt tgccgcagct aaagcatttg 568621 gggcaggcac aatcattgtc accgacttag agccgctgcg gttagaagct gcgaaaaaaa 568681 tgggagcgac tcacattatt aatatacgtg aacaggatgc acttgaagag attaaaacga 568741 tcacgaatga tagaggcgtt gatgttgctt gggaaacagc agggaatcca gcggcattgc 568801 aatccgcact ggcttctgtg cgccggggcg gaaaattggc gattgtcggt ttgccttcac 568861 agaacgagat tccgctcaac gtgccgttta ttgcggataa tgagattgat atttacggga 568921 tcttccgtta tgccaatacg tatccaaagg gaatcgaatt tcttgcttca ggcattgtgg 568981 acacgaagca tctagtaacg gaccaatatt cgctggagca gacgcaagat gcgatggagc 569041 gggcgcttca atttaagaat gaatgtttaa aagtgatggt gtatccaaat cgctgagtga 569101 acagggagga tcttcgtatt ctccctcttg tttactggaa atgaaaacgg attcttgggg 569161 tgggaaatga tgattggaac agaaaaagta acggcattga aggcgaagca tcagtcaaaa 569221 tccagcaccg gcctgtcctg gtttgaacga atcggttatg gattcggcga tatgtcgtat 569281 aatattatct ttcagtttgt aaacgcatac ttattatttt attatacaga cgtcggcggc 569341 attcagcctg cggtaatcgc aactttgttt cttgttgtgc gtgtgctgga tgctattttt 569401 gacccgatca tgggattgat tttagataaa acgaatacaa ggtggggaaa agcaaggcca 569461 tatttgctgt gggtggcatt tccttttgcg ctattcacat tcttatgttt cacgacgcct 569521 catttcggtg agaccggaaa tatggtatat gcgtatgtca cttatattct gcttgggatg 569581 tcctttagta tgcaaacgat cccggtgaac agcttaacgg ggcggatgac gaattcggtg 569641 gaggaacgaa cggttctgac cacaacccgg atgattttgg tgtatatcgg cattctttta 569701 tccatttcct gtgcgacacc gcttgcaact gctatcggag gagaggatca ggcgtttgga 569761 tttcagatga cggcgctcat ctatgcggct gtcagcatcg ttttgaatct atttagtttc 569821 tttactgtac gggagcggat tcagcctaaa aagagaaaaa aacaagggat caaaaagacg 569881 ttatccgttt tattcaaaaa caaacccttg ctcatgttaa tttcatcatt tttggctttt 569941 gcgatcgggt ttaatattaa gctcagcacg atggtgtatt attttacgta taacgtaaac 570001 cataaagagt tcgtgtttat gggcaccgtt ttatttttcg gggcagcgct gatcagcaat 570061 ttgtttattc ctttcttttc tgagaagtgg ggcagaaaac aagtcatgat tatcacggca 570121 gctctatcgc ttatttctta tgccggcctg cattttacgc cgtattcttc aattccactc 570181 attttcattt ggcttttcgc ttcgggattt ttcacaacgc ctttaaatac gcttgcttgg 570241 ggaatggttg cggattgcgt cgattatgcg gaatggaaaa ccggaattcg cgcggatggt 570301 gttgtgattt cgagcatgag ctttattaat aagctgggtg ttgcgttagc cgggtcattt 570361 tcggccattt atttaggaat cgccgggtat gtggcgaata cagaccagac agttgcgtcg 570421 ttgaatgcga ttaaaaatat gaatgctttg attccgggat ttttcatttt gctttctatt 570481 attcttatcg ccttctatcc tttaacggaa aaaagatata aacacatcat ctctgagctg 570541 gagcaaaggt ctgcgagata aatagatgta aaatttttaa tattcaatgt tgtatttatg 570601 gcaaaaagta atatactgag actgtaatct agactttata aatgagtgtg ataatatgcg 570661 tagtcattct gtagtttgta ttggggaatt gttgattgat ttcttttgta ccgatgttga 570721 cgttgattta atggaagggc gccaattcct gaaaagtgcc ggcggggcac cggcgaatgt 570781 gtcggcagcg attgccaagc tgggcggaga cgccgctttc agcggaaaag taggaaagga 570841 tccgtttggg tattttctga agcgaacatt ggacgctgta catgtcgata cctctatgct 570901 ggtgatggat gagaaagcgc ctacaacgct tgcttttgtt tcattaaaac aaaatggaga 570961 gcgtgacttt gtttttaata gaggcgcgga cgctttgttt acgctggagg acattgacca 571021 ggaaaaacta aacgaagcga aaatccttca tttcggctct gcgacggcac tgttatcgga 571081 tccgttttgc tcagcctatt tacggttgat gtcgattgcg aaagacaatg gacagtttat 571141 ttcgtttgac cctaactacc gtgaagattt atggagggga agagtctcag agtttgtaag 571201 tgttgcgaaa aaagcgatcg ctgtaagtga ttttgtgaaa gtcagtgacg aggaacttga 571261 gattatcagc ggtgtgaagg atcatgaaaa gggagttgcg atccttcatg agatcggagc 571321 caacattgtc gctgtgacac ttgggaaaag cggaacgctt ctttccaatg gaaaagaccg 571381 tgaaatcatt ccaagcattc cggtgacatc aattgactca acaggggcgg gagatgcttt 571441 tgtcggtgcg gctttatatc aattggcaaa cacggatcag attcaatctg tagatgctga 571501 ttttgtgaaa ctgcgtgaga ttgtggcgtt tgccaataag gtcggagctc ttgtgtgcac 571561 taaaattgga gcgattgatg cactgccgag tttggatgag attggagttt ctttgtaaat 571621 cattgaagat gtttcttgaa agtctttgga cttttggggg catctttttt tattgcttac 571681 atttttgttc aggtaaaaag ttgtatattt tttgtttgaa atgtcatttt ttattaaaaa 571741 agtgaaactt ttaacgataa taaatagtat atgtaacaag ggttaccgaa ttagctttag 571801 gaggaacgat ataatgagta taattggaag atttaaagat attatgtctg cgaatatcaa 571861 tgctttattg gacaaggctg aaaatccgga gaaaatggta gatcaatatt taagaaatat 571921 gaatagcgat ttggctaagg ttaaggcaga aacagcagct gttatggctg aggagcagag 571981 agcaaaaaga gaatatcacg aatgccaggc ggatatggaa aagatggaaa gctatgcaat 572041 gaaggcgctg caagccggga atgagagcga tgcgagaaaa tttcttgaaa gaaaaacatc 572101 tttggagtca aagctttctg agctgcaggc ggcgaatcaa attgctgcaa ccaatgccgc 572161 acagatgaga aagatgcatg acaaattggt atctgacatt ggagagctgg aagcacgcaa 572221 aaatatgatc aaggcgaagt gggcagtagc gaaaacgcaa gaaagaatga acaaactggg 572281 cgcttctgtt tcaagtacaa gccaatcaat gtctgcattc ggccgaatgg aggacaaagt 572341 aaataaggca cttgatcagg ccaatgcaat ggctgaactg aacagcgctc cgcaggatga 572401 tatggctgat ctgtctgcaa agtatgacac tggcggttca agccaggttg atgatgaact 572461 tgcggcgtta aaagcgaaaa tgatgctcga taagtaatac ataggaggcc gcagctttcg 572521 gctgcggcgt cattttatca taaaatgtga gagggaacgg taatgataat atcttataag 572581 tgtccgaact gcggcagtga tatggcattt gacagtgaaa ccggctcgtt atcctgcagc 572641 agctgcggaa gacaggacaa tattgaaagc cttccgaaag aaaacattgc ggcacggttt 572701 tctgatgatg aagcaaaaga atatcaatgt aaaaactgcg gtgccgtttt gatcacggaa 572761 gctgaaacga cagcaacgac gtgcagcttc tgcggaggtg ctgcaatact tgccgatcgt 572821 ttatcaggac atttggcgcc ggcgaaggtc attccattta caatcagcaa gcaagaagcg 572881 gagcaggcat ttcgaaagtg gtgcaaaaaa ggccttctga caccaagagg tttcatgtct 572941 gctgatcgta tcaaaagcat caccggcatg tatattccat tttggatgtt tgatttaaat 573001 agtgaagtac aggtgagagc aaactgtacc agagtccatc aatatgaaga aggggattat 573061 atttgcacgg aaacagagca ctttgaagcg tttcgtgata tcaatctcga ttatttgaaa 573121 atccctgtcg atgcctctga aaaaatgaaa gacgaattaa tggacaaatt ggagccttat 573181 tcatacgaag agctgaagga ctttcaaacg gcatatttgg ccggttatat tgcggaaaag 573241 tacaattata ccgatgagga gctttttccg agggcaaaag agaaaatcag cagttatata 573301 gattcataca tccattctac tttttccgga tatacgtcag tcaatgtgag ggacaaacat 573361 attcacacga aaaacgtgaa cagcttttac gttttgcttc ctgtttggat ggtcagttac 573421 gattatgaaa gagcggagca tatctttgcg atgaacgggc aaacaggaaa ggtcgttgga 573481 aagccgccga tcagtcgagg aaaagtggct gcatggttta gcggaatagc aggcgggaca 573541 tttcttgcgt tgaagctcgt ctcattgatg atgggaggcg gattttgatg cgtggatttt 573601 ttgggaaagc gatctttgtt gtgctggctg ttttcatcat gatgccttta ctgggtatcg 573661 aagcggtaag agcctctgaa ttgcagcagc atgtgtacga tcgcgctcat ctattgtcaa 573721 aagcggagat cggaaaactt gaatctctct cggcaaagct gggtgcaaag agggacactg 573781 atttcatcat tattacgacc aaaagcacaa acggtgaaga tattgcagac tataccggcg 573841 atttttatga tcgttacgga aaaggcagta cagccattct gacgattgat atgacaaaca 573901 gagaagtgtt tatcgcaggc tttaaaaaag ccgaacagta tttggacaac agcaggctca 573961 atagcatcag aaatacgatt tcatctgatt tatccaatga aaattatttt gaagcttttg 574021 agacatatat tcagctttcc tataaagata tgggcataaa accgggagta aaccctgaca 574081 acatattctt tacatggtgg tttcagctga ttgctgccat cgcagtcggg ggaattgcgg 574141 tttcaatcat gctttatcat gcaggcggca aagtaacggt taatggaagt acatatatgg 574201 atcagcgtac gtctgatgtg attgatcaat acgacactta tattagaacg actgtaacaa 574261 gagaaagaaa accatcagat aaagacagcg gcagcgatgg cggtgttacg aaaggcggca 574321 cgtcatacag tgggagccgg ggcagttttt aaatgtaaga aatagagaaa gggagaggcg 574381 taatgtcgtt tttcagaaat caattagcga atgtagtaga gtgggaagaa tttagagatg 574441 atatgatttt ttataaatgg aacaatcgtg aaatcaaaaa agggagccgt ttaatcattc 574501 gtcccggaca ggatgctgtc tttttgaaca atgggcgggt tgaaggagtc tttcaagatg 574561 atggcgatta tgatattgaa tcagaaatta ttccattcct ttcaacgtta aagggcttta 574621 agtttggctt taacagcggc atgcgagctg aggtgctgtt tgtcaatacg aaggaattta 574681 ccgtaagatg gggaacaaaa caggcgataa atattccggc agcgggaatg ccaggcggga 574741 tgcccattcg cgcaaacggc acatttaatt tcaaggtgca ggactatatc agcctgattg 574801 ataaaatcgc tggcgtgaaa gatcaatatt ttgtagagga tattaaaacc cgtatcattt 574861 ctattctgga tcagcttctc atgaagtgga tcacaagaga agggaaagat atgtttaatc 574921 ttcaagcaaa cgcttttgat attgccaagg gaattcaaga ggacttagat atgcaattaa 574981 taagcgacgg gatgacggtc actggttttc aaatcatgag ctttaattat cctcaagagg 575041 ttcaagatat gattacaaag aacgcttcct acggtatggt tggggatgtg aacagatacc 575101 agcaaatatc aatgacggat ggaatggcat ccggaaagat gagcggaagc ggagcggctt 575161 cggatatggc tggaatgatg atgggaatga atatggccaa tcagatgatg aaccaaatga 575221 atcagaatca gcaggcacag tcatcaggcc cacagtcaac tggcagcgga agcaaaccga 575281 atttctgtcc aaactgcgga acaaaaacgg gcgaagccaa tttttgtccg aattgcggcc 575341 agaagcttgt ataagaatca tacagtgaaa agtccggagt gatcagcact cgggactttt 575401 ttatttagga gaataagcat tacctattgc ttgctcctga acaggccatt ttcgagcccc 575461 cgcttggata attcccagca gcaattgacg acgttccttt attgaattga cggcaatttg 575521 aaatgtttgc tttgataaag ccggtatgcc tgattgttga agctttgaga tgtctggttc 575581 tggcggcgct tgttctgcag gatggatata ggcagtatga acggtatcca gatagttttt 575641 gatacttgag cgcgcttctt tgatatgaag ctgattcggc tgatattgtt caggaattcc 575701 gtatttgaaa atggttagag cctcatccaa tacagcaaca gctataatgg atgattcctg 575761 atgctgcgtg ctgtggtaaa aatgaaggat ggggaaggcg ttatgctgag cggtcagctt 575821 tcccagttct gatgaggcag cgacaagaag aaaatcaatg tcgtgaaaat ctttgccatt 575881 ccatgcatta tggacgattt cagttccgtc atgccctaga cttaatacac tttgggcaaa 575941 ggagcgtttt tgattaaccg cactcaagac ggaaatcaaa tacgtgacag aaaatgtgat 576001 ggtaagcagt ccttgagctg tttcaataat cgtgacaagc ttccataggc ctccgttcgg 576061 agcgaggtcg ccatttccta atgtaaacat gacatagccg gaaaaataaa ttcggtctga 576121 ccaggaagcc ggttcttttg attgagtttc cataagtgag tgagggtcac tcgagtaaat 576181 caaaacccac ccgctccaaa atagactgat ccatatcact aacgtcaggc ataacagcag 576241 aggaccagcc atacttagaa cctttgcgtg gtcaccgctg attttgcggc agcccttcca 576301 cagccaggca gacaggcatc ttgtgatcgg gccggcaccg ctctctaacc ataacgtggt 576361 ccataaaaaa tcaatcatcc ccgctgtcaa taataaaagg cctgcaatga tataaccctc 576421 attcattttg gttgcctccc ttaagtcagc cttcttttat tttcttctct atttcctttt 576481 atcctgagtc tgaaacaatt gaacgaatgt ttgattttac agagaaaaat aggtgggagt 576541 tacccaacac ttactcattt ttcaatatga acagaaaatc acaagatttt tgacttgatt 576601 cacacatttt catgaagaaa aacgttcatt ttccccttga attggtgatt ttccttttat 576661 agagtaaaaa attttcagaa atttatattg actgaaagcg tttttataat tatgataata 576721 tcagatataa caaaaatgtc actataacat cactacaatt gaactattaa gtgactaata 576781 aataccaaat gaacgaggtt atgcacaaag aaatgaccat tgttctttta acgagaaatg 576841 aaatcgcttc catagggatt gacatgctaa gaagaaggga aggttatgag gttattggat 576901 aaaaacatga acaactattt tctgaagcct gcttacgaaa tgtgaggaag gcagcagccc 576961 tggaataagt ttttgacata cgcattttga aaaagactgg gggaaacagt atgaataaac 577021 aaggaaatca aatgtcattt ttacgtacaa ttattttagt ctccactttc ggcgggcttc 577081 tttttggcta tgataccggt gtgctcaatg gagctttgcc gtatatggga gagccggatc 577141 agcttaatct caatgccttc acagaaggcc ttgtcaccag ttcacttctt tttggagcgg 577201 cactgggtgc tgtgtttggc ggcaggatgt ctgattttaa cggccgccgc aaaaatattt 577261 tgttcctcgc tgttatattt tttatttcaa cgattgggtg tacgtttgca ccaaatgtta 577321 cggtcatgat tatttcccgt tttgtgctcg gtattgcggt tgggggtgca tccgtaacgg 577381 tgcctgccta tttagcagag atgtctcctg tggaaagcag gggacggatg gtgacgcaga 577441 acgaattgat gattgtatca ggacagcttt tggcctttgt ttttaatgcg atccttggaa 577501 caacaatggg agacaactcc catgtgtgga ggtttatgct ggtcattgcg tcacttccag 577561 ccttgttcct gtttttcggc atgatcagaa tgcccgagag tccccgttgg cttgtttcta 577621 aaggaagaaa agaagatgct ttgcgtgtat tgaaaaaaat cagggacgaa aaacgggcag 577681 cagctgagct gcaagaaatt gaattcgctt tcaaaaaaga agaccagctt gaaaaagcga 577741 catttaaaga tctttcagtc ccatgggtgc gccgtattgt gtttattgga ttagggattg 577801 cgattgtaca gcaaattaca ggtgtgaatt cgattatgta ttatgggact gaaattctaa 577861 gaaattccgg tttccaaacg gaagccgctt taatcggaaa tattgcgaat ggcgtgattt 577921 cggtattggc aacattcgtc ggaatctggc tgctgggaag agtggggcgc cggccgatgc 577981 tgatgacagg cttgatcggt acgacaacag cattattgct aatcgggata ttctcacttg 578041 tacttgaagg atcaccggca cttccgtatg tagtcctgtc attaacggtc acatttcttg 578101 cttttcagca gggcgccatt tcaccagtga cttggctgat gctatctgaa attttcccgc 578161 ttcgccttcg cggactggga atgggtgtta cggtattctg tctgtggatg gtgaattttg 578221 cagtcagttt cacgtttccg atattgctgg cagctatcgg gctgtccaca acgttcttta 578281 tcttcgttgg attaggaatt tgctctgtct tgtttgtgaa gaggtttttg ccggaaacga 578341 aagggctttc gcttgagcag ctggaggaaa acttccgcgc ttatgatcac agcggggcaa 578401 agaaggattc tggggctgaa gtgattggat aatttaaaaa agaatccgca cccgagtgcg 578461 gattcttttt ggtttcaaat tagttaggtc taacaaggat tttgacttgg cttttctctt 578521 taataagagc cccgaagcct tcctcgatca aatcatctag tacgattttt ttcgttacga 578581 gtttgtcggc tgagaaatag ccttctttca ttaatgacaa tacagccggg aagatgtcgc 578641 ggtatccgat aattcctttt actgtacgtt ctttgattac gatatcgttc ggatggattt 578701 cagcaccttt ttcccaaatg ctgacgatga cggtttcacc ggcaattgta gtggactgga 578761 tggcttgtcg taacaccact gggacaccag tgacttcgaa tgctacgtca acaccgcctc 578821 ctgtacgttc tgcaatctca gcgactacat cgtctgtttt agacggatca acgatgatcg 578881 cgccaagctc ctcagctttt tgctggcgtt caggagaaag ctcaacagcg taaatatcag 578941 ttgcaccggc agccttcagc gcttcaatga caagaagtcc gatcgggccg cagccgaata 579001 cagccgcttt gtcgcctgct ttgagtttgc ttgagcggac agcgtataga gcaactgcag 579061 aaggttcaac gagcgcgcct tgttcatatg ataattcatc aggaagtttg aacaaaagct 579121 cttcatccac agagacgtat tcagagaaac cgccgcctcc gccggctaag ccgaggaatc 579181 ccatttgttc atcaaggttg taggcgcctt ggtggccgtg tgtagcaaaa atcggctcga 579241 ctacaacgcg gtctccaact ttataatttt caacgccttc tccgacttcg acaacttcac 579301 cggagaattc atgccccatt gtgacaggtg ccgtttcatt tgttaatggg tgcggtttgt 579361 caaccggaat aaagatcggg ccgcccagat attcgtgtaa atcacttccg cagatgccgc 579421 accatttgac tttgatcttt acttttcccg gctccgtttt tggctcttcg atatgttcaa 579481 tacggatatc cttttggtta tgccatcttg ctgccttcat ggattaccac tcctataact 579541 tttgatgtga gtaattccgc accggtcaat atgaactgtt cacaaaatcg ccatttttaa 579601 aaccaaaaaa gaaatgaaat ttttatataa tataatctac gtttttttga aaaaaagaaa 579661 ctttaaagaa aaaagggtct cgcacactct tttttcttta tatgagagta tcaatcgttt 579721 acatagctat gaatttggtt tgaacaatac ggtaatggtt cgttcatatt gaatgcgaca 579781 actactctat caataattat aactctaata ctgctattat aataggataa tcttccatgg 579841 tttattttag cagaggtaac ttttttgact ttgtaacatt actgtaagga tattgaaata 579901 aaaaatagct ggttgatcgt gtataatctt cctagatgtt aacaaacagg gggacgaaat 579961 gttgaagaaa gtcattttag ccgcttttat cttagtagga agtactttgg gagcttttag 580021 tttttcatca gatgccagtg cgaaacatgt gaacggaaat attacttggt ataatggagt 580081 cgggaaaaaa ggctcttcag gtaagaaact tggacattgg gattgtgcga ccaaaatcgg 580141 atttgatgtt cctagaaacg ggacaaaaat cagagcttat gcaaaagcga agcctaaaaa 580201 ggtgattacg gtttataaaa atgatgttgg cagaatgcct aatgcagtgc tggatgttag 580261 ccctaaagcg tttaaagcgc ttggataccc attaagcaaa ggtaaagtag cggggcatta 580321 cagctattaa tgtacatata taatctggaa agcaagaagt cacattcttg ctttttctat 580381 tggtggagat aaaagatgaa aaaaagaatc atattattat tagcagtgat aatagcggca 580441 gctgccgcgg gggttgcgtt ttatgttgca aaggataaag gccatgagaa ggctgctgat 580501 gtttcagtca ataccgaaag cggtgatgag ctgctggttt caattacaga tacggatctg 580561 ctgacaaagt attatgaaaa tgacaaggtg atccatgagg agaagctgac cagctatccg 580621 gcatttgcct tggatcaaaa acagcaggtg ctctattata cgggcaataa tgaacagaat 580681 gaaatgaggc tttttaaatt ggatctgaag tctcataaaa aaacgatgct ttataaaggc 580741 gcggagagtg cggacagttt atttttatca aaggaccgtt caaccatcta tttccgctta 580801 ggaaaagcgg acgaaagcaa ttttcgaatc gccgcttttg atctgaagac gaaaaagtat 580861 aaaaatcttt atcctgccgc taatgatcag gatgacaccg tcagcagctt cttttataac 580921 caaaaaaacg attcatttgc attgcttcat tattctgtag aagaagacta caagaaaaca 580981 gatgaagcaa acgaaaaggg catcgaccct gaaccgacaa cgattcattt tgcggaaggc 581041 cgccaaaata aatttaatga gctgaaaagc ctgaaccaat ttatcagcga tattgctgtt 581101 tctgatgatg ataaacgtat tttattcaca tcatatacgc aaaaaggaac ggagcaaacc 581161 gcttctattc aaatgctcaa tgcggatacg aaaaaatatg aaagcatcat ctcaaatcaa 581221 aaatcattta agctgttaat tgacgcacag cctcagtttt ctaaggatgg gaagaacatt 581281 tattttcttg ccgaagccaa gggggctaaa aagctgaagg acgaaacagg gcgtgaagct 581341 aaggtgcgga cgatttattc ctatagcctt gagaataaga ccttcaaaaa agtatgggaa 581401 aatccgaacg gcatcatcaa cagctttttt gtgattaact aataaaaacc actcggcatg 581461 agctgagtgg cttttttaat ggatgaggtg cagggctaat gatccgagcc atttaaagat 581521 atgaatcaga ggtaccgaca aaaacagaag ttcaacatat gagttcattg caacattcag 581581 ctttttgaac gcagctcttt ttttcaagtc tttttgctgc tggtttgaga tcacgttatc 581641 actcctctta tatccatatt ataccattaa aacagacaaa aaagccctaa acgtttacag 581701 ttttgggctt ctttcttcgt atttggcctc ttgcaatgag aggcttttat tctgaaatat 581761 agaattttgt ctccgttcgg ggtttgtttg cttgcgggag actgcatttg ttatagggaa 581821 gaactagctt gttttcgttt ggctgttgtt ttggagattc actaatgaac ggatgccgtc 581881 gaccatttta cttccgcaca aagggcacaa tggcgtatca ctgctggcga agttttttcg 581941 ggtccagcca ttacagtctt cttttgtgca ttcccaagta ctcacatctt cctttggcag 582001 cggttcttga tttcgtttgt tatagtaaga cataaagtca cttcttccct catgtatttt 582061 actgcacatt tcctattgtc tcatactttt ccctaatctc ctaattcctt tttctttatg 582121 actttccaat aaccccatct aaaaaggaga ggagtgtgct gttaaaagca tctggctctt 582181 ctaaaaacgg gcaatggctg cttttaggaa aggtaacgag tgtcgcgttt ggaatattgc 582241 tgcgcaagtg ttccccagct gctgtagaga aaaatttctt gtcttccccg aagcacagca 582301 atgccggcac attgatgttt tggagggtgc cccggtaatc agcggccgtt tggttaaata 582361 aaatcgtgct agaaatggca gccggctgtt tgaggatttc tgccagcatc cattctgttt 582421 cggtctcggc aggcggttct gcgaacatat tctggatgaa gctttcgtag aaaggcagcg 582481 ggtcagtttg aatggcgtgc atcgctgttt ttaagccgtc aaaatcaaat ggaccatgtt 582541 cccagccctc ccattgatag tccgaagcgg attgatcgat gatcacagcg gcttgaatgt 582601 tatcattccc aaactgattg agataatccc atacgacaaa agcacccatt gaccagccgg 582661 caagaacgac atgatcaagc tccattgcat ttagaaattc ccttatgtca cgggcatatt 582721 gggaaatggt gtggccgtga agcactttgt cagattcgcc gtgtcctcta agatcaagac 582781 gaatacattg ataattggca gaaagcaccg aaaattgttt gtggaaaaat tgtccgctca 582841 tcagcacccc atgtataaac aggatcggcg tcccgctccc gtgtgtttca tagtaaaggc 582901 gtgtctgatc ttctaatatg atgtatggca tgtttctcct cctttagttt ccatcatgag 582961 tatggctggc tgctgttgag ctgatgatgg cagctgtcgc ggctgcctgc tgcgcttgaa 583021 tgactgtttc gatagcggtg tatagtcctg attccatcag cagatttttc tccatatgct 583081 cactgagata gaggctgaca gcaattttaa agttcatttc cttttgccat ttaaaagctt 583141 tttcctggtt taattcgtca gtgatgcaca aaacggtttt gatatctggc tcttccagaa 583201 atgtgaggag agcaaggtct ggataatgat aatcctttgt ttttttgaca gattcagtga 583261 tcgattgata tatctgtttg caagcggaaa caagcatttc gggctctttt tcactttgca 583321 aggccagaat atggctgacc tgatgtaagt actgtccttt tttaaagccg ttggctgcca 583381 gcagttgata gcatgtttcc gccttctgta gcgcctgcaa accttttccg ttttctccaa 583441 gcagtacggc aagcggaaca ttctgagttg aagtgaggaa ataatgattt ttcttcatct 583501 gctgataaac agctagcccc atgttcatct gttctttttg gtttgtcgtt tcagatttgc 583561 cggtgagcaa gatcagagcg gaaaggtatg tgaacatatc ccgcttatac cctagcttca 583621 ccatttcatt gtatacatcg atgaaagtct gaaatgtttg ttttgcctca tgctgaaaat 583681 gaatgtccag aatagatgca acagtaaagc ggtggtgtga attgagtgtt gagaagctgc 583741 cgatgtttga tttgatatag ctgctcaaat cataaaagcg ctgaaaatca aactctcttt 583801 tattcacaat atatgcagaa gaaatgagca ttaatatctg atcgtgtgaa actttccatt 583861 ttaattttgt ttttaattca gcataaatgg aaatgtaatg ctttgttttt tcatgtagat 583921 cgtgtgtgag cataaaaagc agctcctttt gttgttttta cgtaatacga taaatagggc 583981 caaaggtttc ataaagaaaa aacttgcctg ctagaggcaa gtttgtcggg ttatttatgg 584041 ggatcagtta tatccatcgg tctcatcatg tcatagtctt catgctctag aatatggcaa 584101 tgccatacgt atcgtccgct gtacggaccg aatgtcgccg cgattctcag gacttcacct 584161 gcatgcgctt gaatggtgtc tttccagccc ttttcacttg gcggcggcgg gacagccgga 584221 ccggtatagg acaattcccc gctttcttga taacgggcga tatcaaacgg ccgccggtct 584281 aatacacgga aggagactag atgcaggtgg atcggatgtg ttccgcgtgt cgggttgata 584341 atggaccata tttcagttgt gccgactttt ggtgtttctg tgacgggatc gtgccagcgt 584401 ttgttattaa gcagaaggac gggtctgccg tattcgtcct gggtgcctgc cagttttaac 584461 gttctgatgt tttgtattct ttcatgctgt accgaagggt atgaggcgag gtacttcggc 584521 tttctgcttt cgtctttttg tgccaatggt tttgtgactc tgaattgcat gatattcgca 584581 tctgtttcag gattgacgtc accgccgcag cccgcgctgt ttgccaaaat gatcgattct 584641 ccttcatatg ctgtgaagtc aatgatgata tcgtaacgtt cagcaggcgc aaggctgaaa 584701 gaattcagtt taacagatcg cggcaggagc cctccatctg aaccaatctg aataaaatct 584761 ccgccattat cgagtgacag gttataggtt cttgtattgg aggcgttgat gacacggaat 584821 cggtatttcc ttggctcgac ttccaagtat ggccatacct tcccgttgac gagtatggtt 584881 tctccgcaaa aagccggaac gattgaagga ttaggcagtg acggagaagg gttttccggt 584941 gcgctcggat aaaacaaaga accatcctca ttgatcgtgc ggtctgtgat aagaagcggc 585001 acatcgtatt cgtctgaagg cagttttaag cgtttttcct ttgggtcatg aatgatatat 585061 gcaccgacaa gtccggcata gacatttagc ctggtgagcg ccatggcgtg atcgtgatac 585121 cacaatatag ccccgcgctg ctggtttgga taatgataaa cctctctttt gaaataaggt 585181 cctgtttgtt caaagtcttt ggaaaaccaa gcctccggat acccgtcact atcatctggc 585241 gtgacgccgc cgtgtaaatg aacaacagtc tttacctcgg gctcttcatg ctggctgtca 585301 ctgtgatgaa tggtgtgatc aatcggaagg aaatgcgtgg aaggaaggtt attcatccat 585361 tttacatata cgttttcatt tcttttaacc tcaatggtcg gtcccggaaa taagccgttg 585421 tagccccaca ggcgggttgg agggagatcg cgatggagct gatgagtgca ttcctccatg 585481 gtgacttcgt agtatgtttt ttcttttgat tgctgtactg gctttagtgt atctgggatt 585541 gggagagcat ccacaaattt ttcaagtgtc attttcatct gtccttatct aaattttcca 585601 aattggtact atagttaatg acaataagga cgtgatggtt acaaaaaatc ttcgtgctgc 585661 agcccgcccg aagaagaaaa taacaaaatc ctaaacggca ggccgtttag gatttgatca 585721 gcattaaggc aggatatcgg gttgctgctg tgtgactggg ttggcagccg ctttctcgct 585781 caccttgcgt tttctgaaca caaggtaaga aatcagaacg attcccgtga tgacgcctgt 585841 cagcagcagc tcgtctctca tggaatcaat aaacgccatg gacactaaaa ttccgcaaat 585901 ggcgatgatg gtcaagtagg ttaggaaagg gaagagccac attttgatct tcaatgcttc 585961 tgggtttgtt ttttcgagtt ttttccgcat tttcagctgg gaaacggcga tgacaagata 586021 gacgagtaaa gcgattgcgc ctgatgagtt gactaagaat aaaaagacgg tatccggtga 586081 aaaatagttc attacgaccg cgatataaga gaaaaatgtc ccggccacaa tggcttgtac 586141 gggaacgcct tttttgctca atttcataaa acggcgcggc gcttcatttc tttctgcaag 586201 tgaatacagc attctggatg tggtatacaa acctgaattc aggcaagaga gtacggctgt 586261 gaggacgata aagttcataa tctgtgcggc tgcgggcact cctatatgct caagtacagc 586321 gacgaaaggg ctttctaaaa tatttgctga attccatggc aacagcgcca cgacaatggc 586381 gattgagccc acgtaaaaga cgatgatgcg ccatacaacg gatctggtgg cttttgtcac 586441 agattcgatc gggttggatg tttcccctgc tgcaatggca acgatttcag ttcccataaa 586501 agagaagatg acaacgacaa tgccgagcaa tacggagctg atgccctccg ggaaaaatcc 586561 gcctttgcct gtaagattcg aaaaaccgac tggctcactg cccggtgcaa agccaaaaat 586621 aaaggcaaaa ccaacgatta gaaaagcaat gatagtcaca actttaatga gggagaacca 586681 atattcaaac tcaccgaaag acttaacgga gtagacgttt gtcagggtga gcacaatggt 586741 caagatcaaa cttgtcagcc acagcggaat atcatggaac cagtattgaa taatgccagc 586801 accggcaatg gcttcgatcg ctatgacgat cacccagaaa aaccagtaca gccagccgat 586861 tgtaaatcct gcccacggtc cgatggcgtc gtgagcgtat tgagaaaacg atccgctcgt 586921 cgggtttacg gcagacatct caccgagcat tctcataata aaaatcacca ataatccggc 586981 taacgcgtaa gaaacaacgg cacccggacc ggtcgagtga atcactgaac cgctgcctac 587041 aaataggccg gctccgatta caccggcaat cgaaatcatt gtcatatggc gggtctttaa 587101 ttcctttttt aatcctgatt gagactggtt cataagttac ctccttttaa aatgcaatca 587161 ttactgaata ttatgataat tgaaactcta tcataaatat acagtttgtc gaaaattcgt 587221 gtaagaaaat ataccagctt atttcaaatt tgtagtgttt tgtttgcgct ttcagcgaat 587281 gtgtggaaaa aatgtttcgt tttttattcg ctgtgtgatt ttgcgtaata tttacaattc 587341 gatagaatgc gagaagcact ggtgtccttg ggtttgatgg gatttttggc ggagcaaata 587401 aattggatga gagaaaaagt gttccttcgt cactattttt ctgtggcggg tgaatcatgt 587461 ttctgtagac ccactgcgga tcagctttgt aagataataa taggaaaatg tgagcgagag 587521 gaggttttgt atggagagat atgatgaact gaaaaaggga gaatccggag cgctggtcag 587581 cattgccgcg tatctagttc tttccgcaat taaactgatc atcggttatc tttttcactc 587641 ggaagcactt acggcagacg ggttaaataa cacaactgac attattgctt ctgttgctgt 587701 gctgattggc ctgcgcatct ctcaaaagcc tcctgacgaa gatcatccat acggccactt 587761 tcgagcggaa acgattgcat cgcttatcgc atcgtttatt atgatggttg tcggactgca 587821 agtgctgttc agcgccggag aatctatttt ttctgctaaa caagagacgc cagatatgat 587881 tgcggcttgg acggcagcgg gcggggcagt cctgatgctg atcgtttacc ggtacaataa 587941 aaggctggcc aaaaaggtga agagccaggc gctccttgct gcggctgctg ataataaatc 588001 agacgcattc gtcagtatcg gcacatttat cggcattgtg gctgctcaat tccatcttgc 588061 ttggattgat acggtcactg cgtttgtgat cggtctgctt atttgcaaga ccgcatggga 588121 tatctttaaa gagtcatctc actctttgac agatggattc gacataaagg acatttccgc 588181 ttataaacag acaatcgaaa aaatctccgg tgtgagccgt ttaaaagaca taaaagcaag 588241 atacttgggc agtacggttc atgttgatgt ggtggttgag gtatcggcag atttaaatat 588301 tacggaaagc cacgatatag ccaatgaaat tgagcggaga atgaaggagg agcatgcgat 588361 tgattattcg catgttcata tggagccttt agaacaaaaa taatggagct tcctgtcaca 588421 ggaagcttca gcgtgtcgac aaaccctcgc attcgttgtc aggtctgcgc ttcggtgctc 588481 acgaattaga acattcgctc cgctcctatg ctcgtccttc ctagacttca agggttttca 588541 atcacgctga aaagatgaca aaaccctaaa atgaaagcca ttttaggatt ttgtcaacaa 588601 tctggagctt cctgccacag gaagcttttt tgtgtgtttt ggccagcttt attggtaaca 588661 atttgctaga atcgtttttt tatacagatt gctttttgtg gtaaagttag gttacattat 588721 gatgaatttt gtagatgact aggaggaaaa taatggcata tcaagaagac ctgcatcctt 588781 tgctggggaa agcagttgaa catattaata gagtaatggt tggaaaacga gacatcgcca 588841 tactcagctt agcagccctt cttgccaaag ggcatgtgct gcttgaggat gtacccggag 588901 tcggaaaaac gatgatggtc cgcgcgctgg caaagtcaat cggcgccgat ttcaaaagaa 588961 tccaattcac tccggatttg ctgccatctg atgtaacagg ggtatctatc tataatgcga 589021 aaacgatgga atttgaatat cgtcccggcc caattatggg aaatatcgtg ctggcagatg 589081 aaatcaaccg tacctctccg aagacacagt cggctttgct cgaagcgatg gaagagggga 589141 gcgtcacggt agatggccat acgatgcagc ttgccgatcc gttttttgtg atggcaacgc 589201 aaaacccggt cgaatatgaa gggacctatc ctttgccgga agctcagctt gaccgttttt 589261 tattcaaact tcggatgggt tatccgtcct ttaatgaaga gcttgacgtc ttatctcttc 589321 aggaaaaaag ccatccgatt gagacgcttg agccggttat tgcaaaagaa gacttcatct 589381 ttttacagag ggaagtgcaa aatgtccgtg ctgatgacag cattaaggaa tatatcgttg 589441 aaattgtgca gaaaacgaga cagcatcctt ctgttcaatt aggcgtcagt ccgcgcggct 589501 caatcgccct catgaaagcg gcacaggcat acgcgctgct gcatcatcgc gactatgtca 589561 taccggatga tattcaatat ttagctcctt tcacgctgcc gcaccggatg atgcttcatc 589621 ctgaggcaaa atttgaaggg attcaggcag aagcgatcgt aagggagatc atgtcagctg 589681 tgaaggtgcc ggttcaaagg tcggcggtcc gctgatgaat aagaaatggc aatggctcgt 589741 atatggttgg aagctgatta tattaacttt attgacggct gctgtttttt cttatgcgat 589801 gtttcagggc ggctttgtca gctggttttt gttttacgcg tttctccctt ttgtcttgta 589861 tgccgggctg ttggccttgt atccgctccg ttcttttcag gcttcaaggc aaatggataa 589921 aacacaattg catgcggggg acaggctggg cgtaacggtt acgctgagaa gaaagctgcc 589981 atttccgctg atgtatatgg tgattgaaga ttgcctgcca gaaggtatcg agtcattaaa 590041 tcgagacgga gccgcggcca aacggctcgt ttttccttgg tttaaacgga gcatgacgat 590101 gtcgtatgaa ttagctcggg taccgcgcgg agagcatcac tttcattctg tcagggtgcg 590161 aaccggggat gttcttggct tgattgaaaa aacagcattt tttgagctgg atgatacctt 590221 gtttgtttat ccattctatc agcgtttttc ctatcaggtg aatgagaggc atcaggaaga 590281 cggtgtaagc ggttcttctc ctattcatca gcaccattcc tcagtcgcag caagtgtgcg 590341 gaattatcag ccgggagacc ggtttgctgc gttagattgg aagacatctg cacggcggag 590401 ccagctgatg acgaaggaat ttgagccttc tcgcagcaaa aatctgtttc tgctgatgga 590461 ccgtttttcc tcagacgcat tcgaagaggt cgtttcagtg acagcttcga ttcttcattc 590521 tgttttaaaa aacggcgcgg gtgctggtct ggcttccatc gggaaggaaa aaaacatttt 590581 ccctattcag gaaggggatc agcattttaa gcacatgctt cggcatttag ccatcgctca 590641 ttgtgatgcg gcagacccga taagccgata tgcacgggaa gagctgggaa agccatctgt 590701 tcgccaagct gatcaagttg ttgtcacggg acagttaacg gaagatatgc tgcacctcgc 590761 agaaatagga ggcggccggg ttacggtgat actggcaaaa gagaaagatg ctgagctctc 590821 tcaagctgaa aatgtcatga ttgaacgcat gatgaaacgc caaatcagag ttcggatcat 590881 gaggggcggg cgagtttcgc gtgttgttta gaaagagagg tgactggttc acatgccgca 590941 cgatgatcac aagggaagcc gtttgagctt gctgttattt tattttctgg cttttttatt 591001 gctgtgggag tggcttaggc cgcttgacag ttttactgaa acgaaacata caggcttttt 591061 tagtgtcttt atcggcttga cgtttctgct gacttttttc aggatgaggt ggtttgtcac 591121 cgttcctttt tgtgtcatat ttacattgat ctcgatacac atcctgtttt atcaaggatc 591181 tatattcgac ttgagctggg tcagctcttt tttgcaggat gtctatctga atatcacgct 591241 gattcaatca gggcaatgga atgacatgat tccttcattt cggaccctgc tgttttttgt 591301 gctgctgtgg ctgctggtct atctcctgca ttattgggtg atttaccaga gaagaatttt 591361 gtttttcttt ttgatgacag tagcgtatat tacgattctt gataccttta cgccatatga 591421 tgccactttt gccgtaatcc gtatcgtgct gatcggcttc tttatgctgg gccttttata 591481 cttggaacgc attaagctga tggaaagaat cacactgcca aaaacatctg tcctgaaatg 591541 gtttcttcct ttatctgtat tggttttggc tgcaacggga ttcggactcg ccgctccaaa 591601 atcagagccg gcttggcctg atccggtgcc ttttcttaaa aaaatcactc atcaagaccg 591661 cgtgtctgca ggggaaagca aaatcggata cgggaatcat gatgaatcac tcggcggccc 591721 gttccagcag gatgctacac ctgtttttac atggcaggga aaagagcgta cgtatttccg 591781 tgtggaaacg aaggacacgt ataccggaaa aggctggatt gaaacagaca caggcatgtc 591841 gtatcagctt agcaatggaa aagttgaaaa tctgtggttt gaccataagg ttgcgacaga 591901 gcgccgcacc gtccgtgtaa aagtcgataa gcactacggg tataaccatc tgatgtatcc 591961 gattggtgcg gaaaccattc agccaaagca ggctgtctca cttgaaatga acggcaacac 592021 ggagcaaatt tctccgatca gtgaacaagc cggtgaaatc agaaatatgg ggaattatac 592081 agtaacgtac aattccccgg tctataagct ggatgaactg agaaaggtaa aagtgagaaa 592141 aaacagtgag gagtacacat tcagcgatcg ctacatgcag cttccagatt cactgccaga 592201 gcgggtgaga acccttgcga tcaaactgac tcaggatcac gacaatatgt ttgataaggt 592261 gaaagcggtt gaggactatt tagggtcaaa tgcgttcaca tatgaaacag aaaacgtgac 592321 cattccgaag aatgatgaag attatgtcga tcaatttctc tttgaaacga aaatgggtta 592381 ttgtgataac ttttcttccg ccatggtggt gctcttgcgc tcggccggca ttccggcccg 592441 ctgggtaaag ggttatacgt ccggcgaata caaagaagca gggaacaaaa atggcagcat 592501 ttacgaagtg acaaataaca atgcccattc ctgggtagag gtgtatttcc cggaacaggg 592561 ctgggttaca tttgagccga ctaaagggtt tacaaatccg gctcaattta catcttctga 592621 cacaaaagac tctggcagcg atagcagcag ctcgccgaag aaagcaaaag agaaacagaa 592681 agaagagaaa aaacagccgc aaaaagagga aaaacaaaag gaaaagcggg agccagctgt 592741 ttctaaaaag ccgtccgctt cgcatactaa tgccggtgcg ggcttgtatg cagcgcttgc 592801 ggttcttgca gtcctcctgg tggcagctgt attgctgtat gttttccgct cgttatggat 592861 tcctgttttc gccgtgagga aattgaagcg gcgcagtgat cagcacgcgt tttttgaggc 592921 atatggcgcg ctgctgaaac aactgaagag aaaaggactg ccgaaacgag acagtgaaac 592981 gctgcgtgat tatgcaaaac gaattgatga aaaatacgac atagaagaca tgtcaaagct 593041 gacattaagc tatgaaaggg cgctttacag aaatgaagat tcttcggcgc tatggaatga 593101 ttcgagagag ttatgggaaa atttaattaa aagaagatgg tcttgaccgc ttatcgacgt 593161 gttgttagaa ttagtgaata ttatcggagt ctgggagcga gttggcctga ctccggcaaa 593221 cggccttgcc aaagagggcg gagcgagctt catatctgtc ctcgtttttt tctgtgtcaa 593281 aaaacttaga ggagattagg tgacaaccat gacaaagtta gtgaatgaaa tgattcttgt 593341 ccttgatttc ggcagtcagt ataaccagct gattacacgc cgtatccgtg aattcggtgt 593401 ttacagcgag ctgcatccac atacattgac ggctgaagaa attaaaaaaa tgaatccaaa 593461 aggaattatt ttatccggcg gtccaaacag tgtgtatgat gaaaactctt tccgctgtga 593521 cgagaaaatc ttcgagcttg atattcctgt tttgggaatt tgctacggca tgcagctgat 593581 gactcattac cttggcggta aagttgaagc ggcaagccag cgtgaatacg gaaaagcaaa 593641 catccgcatc gaaggcacac ctgatttgtt cagagatctt ccgaatgaac aagtggtttg 593701 gatgagccac ggcgatttgg ttgtagaagt tcctgaaggc ttcactgttg acgcgacaag 593761 ccatcactgc ccgaactcag caatgagcaa agcggacaaa aaatggtatg gcgttcagtt 593821 ccacccggaa gtgcgccact ctgaatacgg caatgatctt ctgaaaaact ttgtattcgg 593881 tgtttgcgaa tgcgaaggcg aatggtcaat ggagaacttt atcgaaatcg aaatgcaaaa 593941 aatccgtgaa acggtcggag acaaacaggt tctttgcgcg ctaagcggcg gcgttgattc 594001 ctctgttgtt gctgttttga ttcataaagc gatcggcgac cagctgactt gtatctttgt 594061 agaccatggt cttctccgta aaggcgaagc tgagggtgtt atgaaaacat tcagcgaagg 594121 ctttaacatg aatgtgatta aagtagacgc aaaagatcga ttcttaaaca aactaaaagg 594181 cgtttctgat cctgagcaaa aacgcaaaat catcggtaat gaattcattt acgtgtttga 594241 tgatgaagcg gacaagctca aaggcatcga ctaccttgca caaggtacgc tttacacaga 594301 tatcatcgag agcggtacag caacggcgca aacgatcaaa tctcaccaca atgtcggcgg 594361 acttcctgaa gacatgcagt ttgagctgat cgagccgtta aatacgctct tcaaagacga 594421 agtgcgcgcg cttggcacag agctcggcat tccggatgaa atcgtatggc gtcagccgtt 594481 cccaggaccg ggactcggaa tccgcgttct tggcgaagta acagaagaaa aacttgaaat 594541 cgttcgtgaa tcagatgcaa tcttgcgtga agaaattgca aatcacggct tagagcgtga 594601 tatctggcaa tacttcactg ttcttcctga catccgcagc gttggtgtta tgggtgacgc 594661 aagaacatat gattacacaa tcggaatccg cgccgttaca tcaatcgacg gcatgacatc 594721 tgactgggcg cgtatcccgt gggatgtgct tgaagtcatt tcgacacgta tcgtaaacga 594781 agtgaagcac attaaccgcg tggtgtatga tattacaagt aagccgcctg cgacgattga 594841 gtgggaataa gaatcaatta atggaaacca tctttttggc aattttgccg ggaagatggt 594901 tttatttgtt tattacgaac aaaatccgat tttgcgcgac tattgttcgc tttttgtatt 594961 gttttttcaa aatgaacttg gtacaataga cacagaaatc aaataagatg aattcgtata 595021 atcgcgggaa tatggctcgc aagtctctac caagctaccg taaatggctt gactacgtaa 595081 acatttcttt cgtttgatat aaataaaaca cggttattta ttcaaactga aatccgtctg 595141 tagtcaagcg tcccaaaatg tattgggacg ttttttattt ggcgttttca ggacagaata 595201 aatagcaaag agtgaaggga gtcaaatagc ttgaaaacgt tttttcagtt tgatgagctg 595261 ggcaccagct atcgcaatga aatcattggc ggattaacga cttttttatc tatggcatat 595321 attttgttcg tcaatccgat tacgcttgct ttggagagcg tgaaagattt tccggaggcg 595381 ctgagaattg accagggtgc ggtctttacg gcgacagcgc tggcgtctgc agcaggctgt 595441 atcttaatgg gattaatagc gagatatccg attgccatcg cgccgggtat ggggctgaac 595501 gcgttttttg cgttttctgt tgtccttggt atgggtattt catggcaggc agctttgtcc 595561 ggtgttttta tttcaggtct tattttcgtt gctctttctt taacaggttt tcgtgaaaaa 595621 atcatcaacg ccattccgcc tgagctgaaa ttggcagtcg gtgcggggat cggcctgttt 595681 attacatttg ttggattaca aggttcagga atcattacag cgaatccttc tacgctcgtc 595741 acgatcggaa acattcacag cggtcctgtg ctgttaacga ttttcggtgt gattgtcacg 595801 gttattttaa tggtgcttcg cgtgaacgca ggcgtgttta tcgggatgct attaacagcg 595861 gtagccggca tgattttcgg tttggttccg gttccgactc aaattatcgg cagtgtgcca 595921 agccttgcgc cgactttcgg acaagcgtgg attcacctcc cggatatttt ctctgtacaa 595981 atgctgatcg ttattttaac attcttgttt gtcggatttt ttgatacagc tggtacactt 596041 gttgctgtgg caacacaagc tggtttaatg aaggaaaaca aattgccgcg tgcgggccgt 596101 gcgcttttag ctgattcatc ttctattgtg atcggtgccg tgcttggtac gtctacaaca 596161 acttcttacg tggaatcaag ctcaggtgtc gctgcgggtg cccggtcagg atttgccgca 596221 attgtaacag ggattctctt tttactggct acgtttttct cgccgctcct atcagtcgtt 596281 acgtcaaatg taacagcgcc ggcgcttatt attgttggtg cattgatggt ggcgccgctt 596341 ggcaaaatcg cttgggataa gttcgaagtg gccgttcctg ctttccttac catgatcatg 596401 atgccgttaa cgtacagcat cgcgactggt attgccatcg gatttatttt ctatccgatt 596461 acaatggtgt gcaaaggaaa agcaaaagag gttcatccaa tcatgtacgg gctgtttgtc 596521 gtatttatcc tgtactttat cttcttaaaa taaggaatga aaaaccagct gcactggcag 596581 ctggtttttt tgttgcaaaa gataaaacca tttcatacga tataccgtca tgtagatgtg 596641 ccgccatgct ttacttaaat ggaaatgact tgactgttca ggaaggcttc ggtaccttat 596701 ataagtgttt tattttcttg ctgaatggta ttccgccgta tttttttgat aggagttgct 596761 gacatgacgg aagaaagaaa agaaacgttt gaagaagaaa ttaaccagag tgaaagaata 596821 gatgcagatg aagaaccgct atcgagaatg tccagaaagg cgagccggca aagcaagcag 596881 aagcaaaaac aaaagcagaa accgcgccag gaacgcggtg aatcaactgt taaagacaag 596941 cttgcgtctg tttgggcagc catcaacaga tattgcggtt ttgcgttctc gattttaaaa 597001 tctccggcga aaactgtcgt aacggatggt ttttctcatt ataagtacgg tctgatttca 597061 atgcttatat tcagtatcat tttttcaatt gggaattggt ttcagttaaa ggcaagctgg 597121 aatcggccgc tcggtttcgg agaacgccat catgctttct atgacgggtt tttagttgtt 597181 cttgtgtatt tgctgatctt tttcgcggta atggtctttg ctatatgggc tgtctcccgc 597241 tatatgatga agcagaaggt gacgttcaga gaagcggctg ccgtattggg ttcattgctt 597301 gtacccgtaa ttgctgtttc aatcctttgg ctgatctttg cgatcgtaaa tatcccaatg 597361 ctgacagtac tgtttacggt gctgatcttg ttttccatct tttttatcat cgcgctgtat 597421 gtacagcgtg tgtaccaggc ggcacaagat gcaccaattg attatatcta ttgtgtattt 597481 gcagtagttg cgatagcgct gctgtttacg gcagtgactt ggccgtttat ttctgaatat 597541 attacggcgt cgttgattcc gctttaatga aaaaaccggc taatcctagc cggttttttt 597601 atgtcacact ttttacaaat atatctaaaa aacatagttg atttgtagga ttaacccgtg 597661 tatgatgggg aaaatgctga aaacgtccag cgcaaaaacc tttatgttta aggaggatga 597721 tggacatggc tgatgtactt cgccgagcaa ttaaccaaaa gaagcaattt ttaaaaacca 597781 aattactgct ctcggaattt tatcaaggaa gaggggaaca gcttgctgac tacacgctga 597841 gtgagcttga gaaagaatac aagtcccttc agaaaatgaa aaaagagatc tgacaataga 597901 tataaagagg tgagtctgct gaaaagcggg cttttttgtt ttgattttga aaaggcgaga 597961 aagagggtaa actactactg ttcaacacat aaaagcgtgt cgaaatattt tgcttaagct 598021 tacgggcgaa gctgattgta aacggctcat ttctctagta gaatatgaat gctttgtgca 598081 agctgaagag tagggggatg aataaaatga tgcaaaccat cttatcaaat gggatagcca 598141 tggttctcat aattctcatt attaatattg tctatgtgtc attttttacg ataagaatga 598201 ttttaacgct gaaaggacag cgttatttag cggccggcat cagtacgatt gaaatactgg 598261 tttatgtgac aggactgagt ctggtgctcg ataacttaga ccagattcaa aatgtgatcg 598321 cgtacgcgct cggttacggt cttggcgtaa ttgtcggcat gaaaatagaa gaaaaattgg 598381 cgcttggcta tattatggtc aatgtgatta cgaaggagct cgatcttgat cttccgaagc 598441 agctccgtga aaaaggctac ggcgtgacaa actgggtggc aggcgggctt gaaggcgacc 598501 gcacagccct tcagatcctg acgccgagaa gatatgaact ccagctatat gatacgatta 598561 aaacacttga ttcaaaagcc tttattattg cgtacgaacc aaaaacaatc cacggcggct 598621 tctgggtcaa agcggtgaag aagaggagaa ttaaagaata atggcaaagc cgaagaagaa 598681 aaagtttgaa gtgacagagc agcaaacgat tgatgcggtg cttcagcaaa tgaaagaaga 598741 aggatatctg cctgtaaggc gaatggaaga gcctattttt atggaaaaaa aggaaaatgg 598801 gtcaattcag atcgttccgt gcgggaaaaa aatcgtattt gaagggaaat tgatctaaaa 598861 cacgaacatt agtagaatga atttttgtat cgttcgataa tatcgttgac attatccatg 598921 tccgttgtta agataaacat gaaatcaaaa cacgacctca tataatcttg ggaatatggc 598981 ccataagttt ctacccggca accgtaaatt gccggactat gcaggaaagt gatcgataaa 599041 actgacatgg atatatcgca gaagcgaacg actgacgata catgtaccat gcccggtttg 599101 tattgcttcc tcataagtgc aatgcagagc gggtattttt tattttctga aaacaaaagc 599161 attagaaggt ggggaacaga atgcagccgc tagtaggaat catcatggga agcacttccg 599221 attgggagac aatgaaacac gcatgcgaca tacttgacga actcaatgtt ccgtacgaaa 599281 aaaaggtcgt ttccgctcac cggacgcctg atttcatgtt tgaatatgct gaaactgcta 599341 gagaaagagg catcaaggtg attattgccg gtgccggagg agcggcgcat ctgccaggga 599401 tgacggctgc gaaaacaaca ctgccagtca ttggagttcc ggttcagtcc aaggcgctga 599461 acggaatgga ttcacttctt tccatcgtcc aaatgcctgg aggcgtgcct gttgcgacaa 599521 catccatcgg caaagcgggt gctgtgaacg caggcctgtt agcggcgcaa attttgtcag 599581 catttgacga agaccttgcc cgtaagctgg atgagagaag agaaaataca aaacagacag 599641 tgttagaaag cagtgatcag cttgtctaaa caaatcatct atccgggagc tgtaatcggc 599701 attatcggcg gcggccagct tgggaaaatg atggctgtgt ccgccaaaca aatggggtat 599761 aaagtcgcgg tcgttgatcc ggtgaaagat tcgccgtgcg ggcaggttgc ggatgtcgaa 599821 attaccgctc attataatga ccgtgaagcg attcgaaaat tggctgaaat cagcgatatc 599881 atcacatatg agtttgaaaa catcgactat gatgcgctgc attggctaaa agatcatgcg 599941 tatctcccgc aaggaagtga gctgctgctt attacccaaa accgtgaaac agagaaaaaa 600001 gcaattcaat ccgcgggctg tgaagtcgca ccgtacagca tcgtcaaaac aaagaatgaa 600061 ttgaaacagg cagtacagga gctcaggctt ccggcagtgc tgaaaacatg ccgcggcggg 600121 tacgacggca aaggccaatt tgtgataaaa gaagaggcgc aaatggagca ggcagccgct 600181 ctgttagaac acggaacttg cattcttgaa agctgggttt cttttaaaat ggaactgtcg 600241 gtgatcgtcg ttagatcggt aaacggtgaa atttcaacat ttccgacagc tgaaaacatt 600301 caccacaaca atattctttt ccaaagcatc gtgcccgcac gggtagagaa agggattcag 600361 cagaaggctg ctgatctcgc agttaagctt gcagatgagc ttaaccttgt cggaccgctt 600421 gctgttgaga tgttcctgac agaggacgga gagcttttgg tcaatgaact ggcgccaaga 600481 ccgcacaatt cagggcatta tacgctggac ctttgcgaga cgagccagtt tgagcagcat 600541 atcagagcgg tatgcgggct tccgcttggg aagacagatt tgctgaagcc gggcatgatg 600601 gtgaatcttc tcggcgatga agtgaagctt gttgaggaag acccggagct tttaaaagag 600661 gcaaagctat atatatacgg aaaacatgaa atcaaaaaag gccgcaaaat ggggcatatt 600721 acatttatga agcagcctga agacgaatgg attcaggaga tcacaaataa atggatgaat 600781 agagacggag gacaagcaga atgatcgaac gttattcaag acctgaaatg tccgcgattt 600841 ggacggatga aaacagattt caagcatggt tagaggttga aattcttgcc tgtgaagcgt 600901 gggcggagct tggcgtcatt ccgaaagaag atgtaaaggt tatgcgcgaa aacgcgtcat 600961 ttgacatcaa ccgcatttta gaaatcgaaa aggacacgcg ccatgacgtt gtcgctttta 601021 cgcgcgctgt atccgaatca ctgggcgaag aaagaaaatg ggtgcattac ggcttaacgt 601081 caactgacgt tgttgatacg gctctttcct acttattaaa acaggcaaac gatattttgc 601141 tcaaggatct tgagagattt gttgacatta taaaagaaaa agcgaaagaa cataaataca 601201 cagtcatgat ggggcgcaca cacggcgtac acgctgagcc tacaacattc ggcttaaaac 601261 ttgcgctttg gcatgaagaa atgaaacgta atcttgagcg cttcaaacaa gcgaaagcag 601321 gcatcgaggt tggaaagatt tccggtgctg tcggcacata tgcgaacatt gatccatttg 601381 ttgaacaata tgtctgtgag aagctcggat tgaaagcagc accgatttcc actcaaaccc 601441 ttcagcgtga ccgccatgct gactatatgg caacacttgc tttgatcgcg acaagcatcg 601501 agaaattcgc tgtggaaatc cgcggactgc aaaagagtga aacacgtgaa gtagaggaat 601561 ttttcgcgaa agggcaaaag ggttcatctg caatgccgca taaacgaaat ccgattggct 601621 ctgaaaacat gacaggcatg gcgcgcgtga tccgcggcta catgatgaca gcttacgaaa 601681 atgttccatt atggcatgag cgcgatattt ctcattcttc agcagaacga attattcttc 601741 cggatgcgac aattgcgctg aactacatgc tgaaccgctt ctccaacatc gtgaagaact 601801 taacggtctt cccggaaaac atgaagcgca acatggaccg cactctcggc cttatctatt 601861 ctcagcgtgt gctccttgct ttgattgaca caggcctgac tcgtgaagaa gcctatgata 601921 cagttcagcc gaaagcaatg gaagcgtggg aaaaacaagt gccgttccgc gagcttgtgg 601981 aagcggaaga gaaaatcacg tcacgtcttt ctccagaaaa aattgctgac tgctttgatt 602041 acaattacca tctgaaaaat gttgatctga tctttgaacg tttaggttta gcatagaaga 602101 agcttttagc ggcttcttct aagccgccgc agtttgaaaa ttcccaacat tcgggttagg 602161 aggccttccg tgaatattgt gaagaatgaa cttttatacg aaggaaaagc aaaaaagatc 602221 tacaaaaccg atgacgaaaa cacgctgtat gtcgtgtata aagactccgc cactgccttt 602281 aacggcgaga aaaaagcaga aatcagcgga aaagggcgct taaataatga aatttcaagc 602341 ctcattttca aacaccttca tgctaagggc attaacaatc attttatcga gcgcatttcg 602401 gaaacggagc agctcattaa aaaggtaacg attgtgccgc ttgaagtcgt ggtaagaaat 602461 gttgtggcag gaagcatgtc caaacgtctc ggcattccag aaggcacgga gcttgagcag 602521 ccgattatcg agttttacta caaggatgac gcgctgggtg atccgctcat cacagaagat 602581 catatttggc ttttgaaggc ggcgactcct gagcaggtag aaaccattaa gtccattaca 602641 acaatagtaa atgaagagct tcaaagcatc ttcgacgatt gtcatgtcag attaatagat 602701 ttcaagcttg aattcggttt agatgcagaa gggcaagtgc ttttggcgga tgaaatatct 602761 cctgacacat gccgcttgtg ggataaagaa acgaacgaaa agctggacaa agatttattc 602821 agacgcaatc tgggaagctt aaccgacgca tacgaagaga ttttcaatag actgggaggc 602881 attcatcatg tataaagtaa aagtttatgt cagcttaaaa gaaagtgtac tagatccaca 602941 agggagcgct gtccagcatg ccttgcacag tatgacttac aacgaagttc aagatgtgcg 603001 catcgggaaa tacatggagc ttaccattga aaaatctgac cgtgatcttg acgtgctagt 603061 gaaagaaatg tgcgaaaaac ttcttgcgaa cacagtgatt gaagattata gatatgaggt 603121 tgaggaggta gtcgcacagt gaaatttgcg gtgattgtgt tacccggctc caactgtgat 603181 atcgatatgt atcatgctgt aaaggatgag ctcggccatg aagtggaata cgtctggcat 603241 gaggaaacaa gccttgacgg cttcgacggc gtgttaattc cgggaggatt ttcttacggc 603301 gattacttaa gatgcggcgc catcgcccga tttgcgaata ttatgccagc tgtcaaacaa 603361 gcagcggctg aaggaaaacc tgttcttggc gtctgtaacg gattccagat tttacaggag 603421 cttgggctgc tgccaggcgc aatgagacgc aacaaagatc tgaagttcat ttgccgtccg 603481 gttgaattga ttgttcagaa cgacgaaacc ttattcacag cttcctacga aaagggagaa 603541 tcgattacaa tcccggttgc ccatggtgaa gggaatttct actgtgatga cgagacgctt 603601 gctacattaa aggaaaacaa tcaaattgct ttcacatacg gctctaatat taatggaagt 603661 gtcagcgaca ttgccggtgt cgtgaatgag aaaggcaatg tattaggcat gatgcctcac 603721 cctgagcgcg cggtcgatga actgcttgga agcgccgacg gtcttaaatt gttccagtct 603781 atcgtgaaaa attggaggga aactcatgtc actactgctt gaaccaagta aagaacaaat 603841 aaaagaagag aaactgtatc agcaaatggg tgtcagtgat gatgagtttg cattgataga 603901 atccattctt ggaagattgc cgaactacac agaaatcgga attttttctg tcatgtggtc 603961 tgagcattgc agctataaaa actcaaagcc gattctgcgt aaattcccga caagcggcga 604021 gcgtgtgctg caggggccgg gggaaggcgc cggaatcgtt gatatcggtg ataaccaagc 604081 ggttgtgttc aaaattgaat cacataacca cccatcagct ctcgagcctt accaaggcgc 604141 tgcgactggc gtaggcggaa ttatccgtga tgtattctca atgggtgcac gcccaatcgc 604201 tgtattgaac tctcttcgat ttggtgaact gacttcaccc cgcgtgaagt acttgtttga 604261 agaagtagta gcgggtatcg ccggatacgg caactgtatc ggcatcccga cagtcggcgg 604321 agaagtgcag tttgacagca gctatgaagg aaatccgctc gtcaacgcaa tgtgcgtcgg 604381 tttaatcaac catgaagaca tcaaaaaagg ccaggcaaag ggtgtcggca acacagtaat 604441 gtacgtagga gcgaaaacag ggcgtgacgg catccacggc gctacgtttg cttctgaaga 604501 aatgtcagac tcgtctgaag aaaagcgttc tgctgtccaa gtcggcgatc cgtttatgga 604561 gaagcttttg cttgaagcat gtctggaagt catccaatgc gacgccttag tcggcattca 604621 ggatatggga gctgccggtt taacaagctc aagtgcagaa atggcaagta aagccggttc 604681 tggcattgaa atgaatcttg acctgattcc tcagcgcgaa acaggcatga ccgcgtatga 604741 aatgatgctt tctgaatcac aagaacggat gcttttggtt attgagcgcg gacgtgagca 604801 ggaaatcatc gatatttttg acaagtatga tcttgaagcg gtttctgtcg gacatgtgac 604861 agatgataaa atgcttcgcc tgacacataa aggagaggtt gtgtgcgagc tgcctgttga 604921 tgccttggca gaagaagcac cggtttacca taagccttct caagagcctg cttactatcg 604981 cgagtttttg gaaacagacg ttccggctcc gcaaattgaa gatgcgaatg aaatgctgaa 605041 ggcccttctt cagcagccga cgattgcgag taaagagtgg gtttatgatc agtatgacta 605101 catggtgcgc acgaatacag ttgtcgctcc tgggtctgat gctggtgttc tcagaatccg 605161 cggaacgaaa aaggcgctgg cgatgacgac agactgtaac gcgcgttatc tctatcttga 605221 tcctgaagtc ggagggaaaa ttgctgtcgc tgaagcagcg cgcaacatca tttgctcagg 605281 cgcagaaccg cttgcggtga cagataacct taacttcgga aaccctgaga agccggaaat 605341 cttctggcag atcgaaaaag cggcagacgg cataagcgaa gcgtgcaatg ttctcagcac 605401 tccggttatc ggcggtaacg tatcgcttta taacgaatca aacggcacgg cgatctatcc 605461 gacaccagtt atcggcatgg tcggcctaat tgaagataca gcgcacatta caacacagca 605521 tttcaaacaa gcaggagatc tcgtatacgt gatcggcgaa acaaaaccag agtttgccgg 605581 aagcgagctg caaaaaatga cagaaggccg tatttacggc aaagcgccgc aaatcgatct 605641 tgatgtagag ctgtctcgtc aaaaagcact gcttgacgcg attaaaaaag gcttcgttca 605701 atctgcgcat gatgtgtctg aaggcggctt aggcgtagcg attgcggaaa gtgtcatgac 605761 gacggaaaac cttggcgcta atgtgactgt agaaggggaa gcggcgttat tattctctga 605821 atctcaatct cgcttcgtcg tttcagtgaa aaaagaacat caagctgcgt ttgaagcaac 605881 tgtcaaagat gcagttcata ttggtgaggt aacagctgac ggaattctgg cgattcaaaa 605941 ccaagacgga caacaaatga ttcatgcgca aacgaaagag cttgaacgcg tatggaaagg 606001 agctatccca tgcttgctga aatcaaaggc ttaaatgaag aatgcggcgt ttttgggatt 606061 tggggacatg aagaagcccc gcaaatcacg tattacggtc tccacagcct tcagcaccga 606121 ggacaggagg gtgctggcat cgtagcgact gacggtgaaa agctgacggc tcacaaaggc 606181 caaggtctga tcactgaagt atttcaaaac ggcgaactca gcaaagtaaa gggaaaaggc 606241 gctatcgggc acgttcggta cgcaacggct ggaggcggcg gatacgaaaa tgttcagccg 606301 ctcctcttcc gttcccaaaa caacggcagc ctggcgcttg ctcataacgg aaatcttgtc 606361 aacgccactc agctgaagca gcagctcgaa aatcaaggga gcatctttca aacctcttcg 606421 gatacagagg ttttggctca cctgatcaaa agaagcggac acttcacgct gaaggatcaa 606481 attaaaaact cgctttctat gctgaaaggc gcctacgcgt tcctgatcat gaccgaaaca 606541 gaaatgattg tcgcacttga tccaaacggg ctgagaccgc tatccatcgg catgatgggc 606601 gacgcttatg tggtcgcatc agaaacatgc gcatttgacg tcgtcggcgc aacgtacctt 606661 cgcgaggtag agccgggaga aatgctgatc attaatgatg aaggcatgaa atcagagcgt 606721 ttttccatga atatcaatcg ttccatttgc agcatggagt acatttattt ctccagacca 606781 gacagcaata ttgacggtat taatgtgcac agtgcccgta aaaaccttgg gaaaatgctg 606841 gctcaggaat ccgcagttga agctgacgtc gtaaccgggg ttccggattc cagtatttca 606901 gcggcgatcg gctatgcaga ggcaacaggc attccgtatg agcttggctt aatcaaaaac 606961 cgttatgttg gcagaacgtt tattcagccg tcccaggctc tgcgtgagca aggcgtcaga 607021 atgaagctgt ctgcggtgcg cggggttgta gaaggcaaac gcgtcgtgat ggtggatgac 607081 tctatcgtgc gaggaacaac tagccgccgg attgtcacga tgctaagaga agcgggtgcg 607141 acagaggtgc atgtgaaaat cagttcaccg ccgatcgctc atccgtgctt ttacggcatt 607201 gacacttcca cacatgaaga actgatcgcg tcttcgcatt ctgttgaaga aatccgtcag 607261 gaaatcggag ccgataccct ctcatttttg agtgtggaag ggctgctgaa aggcatcggc 607321 agaaaatacg atgactcgaa ttgcggacag tgtctcgctt gctttacagg aaaatatccg 607381 actgaaattt accaggatac agtgcttcct cacgtaaaag aagcagtatt aaccaaataa 607441 aacttgaaaa atgacataaa ggcagcgcag ttcggctgcc tttctctttc tgccctcgtt 607501 cggggagata ttttgaaaag cgccttaaag gagtgaatag gatgtctgaa gcatataaaa 607561 acgcaggagt tgacatcgaa gccggatatg aagctgtaaa acgaatgaaa aaacacgtgg 607621 agcgcacgaa acggcttggc gttatgggca gccttggcgg ttttggcggc atgtttgacc 607681 tgtctgagct ttcttatcaa aaaccagttc tcatttcggg aacggacggt gtcggcacaa 607741 aattaaagct cgctttttcc atggataagc atgacacgat tggcgtggat gctgttgcaa 607801 tgtgtgtcaa tgacgtgctg gcacaaggtg cagagccgct gtttttcctc gattatttag 607861 cggttggcaa agcggaccca gtgaaaattg aacagattgt acaaggtgtt gcggaaggct 607921 gtgagcagtc aggttcagcc ttagtcggcg gtgaaacggc tgaaatgccg gggctctata 607981 cagctgatga atacgatatt gccggtttct cagtcggagt ggcagaaaag gacgaaatcg 608041 tgactggaga aaaaattgaa gagggccatc tgttgatcgg cctcagctcc agcggccttc 608101 acagcaacgg cttttccctt gtcagaaaag tgcttctgga tgatgcggag ctggacctcg 608161 atacaacata tgagccgttt gaacgcccgc ttggcgagga attgcttgaa ccgacaagga 608221 tttacgtgaa gcctgtgctt gccgcggtca aaagcggaaa aatcgacggc atggcgcacg 608281 tgacaggcgg aggatttatt gaaaatattc cgcgtatgct tccggaaggc ttaagtgcgg 608341 aaattgatca tggctcatgg ccgatcccgc cgattttttc tttcttgcaa gagtacggca 608401 agctaaagga agaagacatg ttcaacgtct ttaatatggg tatcggtttt gttttggcag 608461 tcaaagaaga gcatctgaca gatgtgatcg gaacgcttga aagccatggc gaaaaagcct 608521 atttaatcgg gcgtgtgaaa aaaggtgaag gcgtcacatt cggcggtgcg gcactttcat 608581 gaaaaagttt gcggtatttg catcaggaaa cggttcaaac ttcgaagcca tcgtcacgcg 608641 tttgaaggag gagaactggg atgcgtcagc agcgctcctc gtttgcgaca aaccgcaggc 608701 gaaagtcatc gaacgggcgg aagcattcca cattccatcc ttcgcatttg agccgaagtc 608761 ttatgaaaac aaggctgcat ttgaacaagc catcattgaa cagcttcgtc ttcacgaggt 608821 tgaattgatt gctcttgccg gctatatgag gctgatcggt gatacgctcc ttcaagcata 608881 tgggggaaaa atcattaaca ttcacccatc gcttcttccg gcgtttcctg gaatcgacgc 608941 agtcggacag gcgttccggg cgggtgtgaa ggtggccgga atcaccgtgc attatgtcga 609001 tgaaggaatg gatacaggtc cgatcatcgc tcaaaaggca atcgaaattg atgaacatga 609061 tacattggaa acaatcgaac agcgaattca caagcttgag cataaatggt atccgagtgt 609121 gattaaacag ctattaggat taaataacag aggtgaaaag gcatgaccat taaacgtgca 609181 ttaatcagtg tttcagataa aacaaatctc gttcctttcg taaaagaact gacagagctt 609241 ggcgttgaag tcatctccac aggcggaacg aaaaagcttc ttcaagaaaa cggtgtggat 609301 gtgatcggaa tttctgaagt gacaggcttt cctgaaatta tggacggccg gttaaaaacc 609361 ctacacccga atattcacgg cggccttctg gcggttcgcg gcaatgaaga gcatatggcg 609421 cagatcaatg aacacgggat tcagccgatt gacctcgttg tcgtcaacct ctatccattt 609481 aaagaaacga tttctaaaga agacgtcacg tatgaagaag cgatcgaaaa tatcgacatc 609541 ggcggacctg gcatgctgcg cgcggcatca aagaaccatc aggatgtcac ggttatcgtc 609601 gatccggccg attacagccc agtgctaaat caaatcaaag aagaaggcag cgtatctctt 609661 cagaaaaaac gcgagctcgc ggcaaaagta ttccgtcata ctgcggcata tgatgcactg 609721 atcgctgact atctgacaaa tgttgtcggt gaaaaagaac cagagcaatt cactgtgaca 609781 tttgagaaaa aacaatcgct tcgctatgga gaaaacccgc atcaggaagc aactttctat 609841 caaacagctc ttcctgtcaa aggctccatt gcgcaagcag aacagcttca cggaaaagag 609901 ctttcttaca acaacattaa agacgcggat gctgcagttc aaatcgttcg tgaattcact 609961 gaaccggctg ctgttgctgt gaagcatatg aacccgtgcg gcgtgggaac aggaaaaacg 610021 atcgcagaag cgtttgacag agcgtttgaa gcggataaaa catctatctt cggcggcatt 610081 atcgcgctga accgtgaagt ggacaaggca actgccgaag cgcttcacaa cattttctta 610141 gaaatcatca ttgcgccttc attcagccaa gaagcgctcg acgtcctgac tgcgaagaaa 610201 aatctccgtc tgctgacgct tgacgtatcc gccgctgttc aaaaggaaaa acagctgaca 610261 tccgttcaag gcgggctgct gattcaagat ttagatatgc acggcttcga tgatgctgag 610321 attagcattc cgacaaaaag agagccgaac gagcaagagt gggaagactt gaagcttgct 610381 tggaaagtcg tgaagcatgt gaaatcaaat gcgattgttc tcgcgaagga caacatgaca 610441 gtcggcgtgg gagcaggcca aatgaaccgc gtcggatcgg caaaaatcgc aatcgagcaa 610501 gcaggggaaa aagcgaaggg cagcgcgctc ggttcggatg catatttccc aatgccagat 610561 actgtcgaag aagcggcaaa agcgggcgtt acagccatca ttcagccagg cggatcgatc 610621 cgagatgagg attccatcaa aaaagcggat gaatacggca ttgccatggt attcaccggc 610681 atcagacact tcaaacatta aggggatgaa aacgacgtga atgtattaat tatcggtaaa 610741 ggcggaagag aacatacgct ggcgtggaag gcagcgcaaa gcagcctcgt cgagaatgta 610801 tttgccgctc ccggaaatga cggcatggca gcttccgctc agcttgtaaa cattgaggaa 610861 agcgaccacg cagggcttgt ctcatttgca aaacaaaatc aggtcggcct gaccattgtc 610921 ggccctgagg ttcctttaat tgaaggtctg gtggatgaat tcgaaaaagc gggcttacat 610981 gtgttcggtc cgtcaaaagc tgcggcgatc atcgaaggaa gcaaacagtt cgctaaggat 611041 ttaatgaaga aatacgacat tccgaccgca gaatacgaga cgtttacatc ctttgatgag 611101 gcgaaggcat atgtgcagga aaaaggtgct ccgattgtga taaaagcaga tggacttgca 611161 gctggaaaag gcgttactgt ggctatgaca gaggaagaag caattgcgtg cttgcatgac 611221 tttcttgaag atgaaaagtt cggtgatgcg agcgcgtccg ttgtcattga agaatatctt 611281 tctggtgaag aattttctct aatggccttt gtcaaagggg aaaaggtgta tccgatggtg 611341 attgcccagg atcacaagcg ggcgtttgac ggagacaaag gcccgaatac aggcggcatg 611401 ggcgcctact cgccagttcc gcaaatttcg gaagaaacgg tccgccatgc tgtagaaacg 611461 atcgttaagc cggctgcaaa agcaatggta caagaaggcc gttccttcac tggcgttttg 611521 tacgctggat tgatgcttac tgaaaacggc tcgaaggtca ttgaatttaa tgcccgtttc 611581 ggcgatccgg aaacacaggt cgtgcttccg cgcatggaat ctgatctggt acaggtgctt 611641 cttgatcttt tagatgataa ggaagttgac ttaagatgga aggataccgc ggcagtgagt 611701 gttgtgcttg catcagaagg gtatccggaa agctatgcaa aaggcacgcc gatcggcagc 611761 cttgcagcag aaactgagca ggtcgtggtc ttccatgccg gaacgaaagc agaaggtgga 611821 gagttcgtta caaacggggg gcgcgtcgcc aatgtgacgg cttttgatga aacgtttgaa 611881 gcggctagag accgagtgta caaagcggtt gatgaaattt tcaaaccggg actctttttc 611941 agaaaagaca ttggggcacg cgctttaaag gctgcccaaa aataagtgag gaaaacccgc 612001 agaatagctg cgggtttttt gttatcaaaa agcgggatgg cagctagaag aagaaagcac 612061 aacgagcgtg gttggttttc catgggccat cgaggtgtca ataaaatcct caagcgtatg 612121 taccgattca gtcacgacct ttgtcacata gctgtacatc cccgtgatgc ggtggttttc 612181 tgctacatca ggatgcgatg ttgcaaaggc ggcgtagtgc ttgcagcttt tcggctccat 612241 gagaataaaa gcggtgacat gcttgtttag tttttcgtaa cagatattcg cgctgtagcc 612301 ggtaatcact cctttgtctt ccagcttcct gacacgctcc gccgcgcttg gcgagctgag 612361 tccgacaagc tttcccagct caaccatcgt taatctgccg tttcgctgca aatgcgagag 612421 aatctgaagg tctgtatcgt ccatttgtct ggctccttta catatttagg cgaatgaatg 612481 aaaattcctt tgatcgtaag gtaatgctgt tgatttaact tcattgtagc atatggatgc 612541 cgtcttattt tttctataat aaagccatca atcagagagg gggcatcatg ttgccagaat 612601 tgcagcgctc tattacttgg atacaaggga cggcgttaac gattggggcg gttttaggat 612661 gcgggatatt aatcctgccg tctgtcaccg cggacacggc cggccccgct tctttatttg 612721 tttgggtgtt catgtccttc ttatcctttt ttcttgtcgg cacgctggcc cggcttgtga 612781 aaatagcgcc tagcgcggga ggaatcacgg cttatgtgca gctggccttt cagaaaaaag 612841 ccggggctat tttgggctgg atcatgttag ggtccgttcc gatcggcgtt cccatcatcg 612901 ctttgactgg cgcgcattac gtcagttaca tcacagaggc ggccgattgg cagattacat 612961 tgattgctgg ttgcatgctg gctatatcta ttttgcttca tatgagaggg attcaactat 613021 cagcaaacat tagtacactc gttatatgtg tcatcgtatt tctgcttgtc acttctattg 613081 ctgtgtcatt gccacacgtc acgatagcag aattcaagcc gtttcttccg catggctggt 613141 ctgccgctgg atctgtttct gttatgattt ttttctcttt tgtaggctgg gaaatgatta 613201 ccccgttggc tgaggaattt catcgtcctg aaaaagatgt cccgctcagc ttgtttttgg 613261 cagcgtcttg tgtggcgggg ctgtatatca tgctgtcatt tgtgaccgtg ggtactcatt 613321 catatggaga gaatggagaa attgcatcgc ttgccatgct catttcaaaa ggagcaggag 613381 aaagcggtgt atatgtcacg gtatgtttag cgctgtttat tacattcgcc accatccatg 613441 ccaatattgc cggtttttca agaatggtgt acgcattggc gagagagggg cacatacccg 613501 tattttttgg aaaactcagt gcgacaaaac gtacgcctat tcgcgttttg acagcgatgg 613561 ccgcagtgtt tggcttagtg cttgcagcgc atggtctgtt tcaaatcgat ttgacgactc 613621 tgttgaaagg gccgagcgcg gcttttatcg catcttacat atgtacaatg gcggcagcac 613681 tgaaactgct gggcaggaga gatataggct ggtggatggc gctcggggca tttgtggcgt 613741 gcgcggtgat ttattcattc agcggctggg cactgcttta tccggcagtg ctggcagctg 613801 caggatattt ctatatgaaa acaaagggtg ggcataaaaa aaagcttgat cacgttttgt 613861 gatcaagctt ttccatttat ccgttttgat gctcgttatt tccagaatcg ctgtgttgaa 613921 acatgtaggt cacaggacag aagcgcaaga ttcccgaacc cgctttcatg gcccccataa 613981 agatgtaaaa gagatgcatt ctgcaccaag gttttttcgt aaactttgca ctggcggctg 614041 acataatcgt caatccgcag gcgattctga acacggcatt gatgagactg atgtttggct 614101 tcaaggaaat ccgctccttt tacttaaaaa agttttttaa tcgaaccttc aaaaatttgt 614161 aacgttttta tcgtgcgtga tgaggaagga tgtgatacca tgagtctaat acatgtaaag 614221 gagagtatgt gaatgtccga acgcaccttt aactggaaaa acaaagacat cagggcacag 614281 gttgatgttg tagactcaaa gctgcttcca acgctccttt tacggaatgc tctcgtctta 614341 aatccatatg taaaacaatg gctgaaaaaa aacatttgga tttatcagga ccgcattgtt 614401 tatgtgggtc atgaacttcc gaatagagcc gaagaaattc atacgattga ttgtgaagga 614461 aaatacattg tgccaggtta tattgaaccg cacgcacatc cttttcaaat atataatccc 614521 caaacactgg cggaatatgt gtctcaatac ggaacaacga cattcgtgaa tgataactta 614581 tttttgcttt tgcaaagcgg aaaaaagaaa gcgcttacga ttttgaatga actcaaaaag 614641 cagcctgtcc agtatttttg gtggtcacgc tatgacctcc agaccgaggt tctgaacgag 614701 gaccacgtcc ttccatttga cgtcagaaaa cagtggattg aacatccgga tgtgattcaa 614761 ggcggagaaa tgaccggatg gcctcgcctg gtagatggtg atgatttaat gctccactgt 614821 atgcaagcta caaagaaaca gagaaaacgt attgaagggc attttcccgg cgcttctgat 614881 aaaacgctta caaaaatgaa gctgttcggt gcggattgtg atcatgaagc gatgacaggt 614941 gatgaagtga tgagaaggct ggaactgggc tattatgttt cccttcggaa ctcttccatt 615001 cgccccgatg taagaaaaat cttgcaagag ctgcatgaga agggcttccg ctattatgac 615061 cacttctttt acacgacaga tggcgcaacc ccgaatttct ataaaggcgg catgacaaac 615121 gagctgattc gcattgcgtt agaagaaggc gtacctgcaa tcgacgccta caatatggca 615181 tcatttaata tcgcaaagta ttaccaaatg gatgattatt taggagttgt cggaccgggc 615241 agactggcat cgctaaacat actggaagat ccgttaaatc cgaatccagt gactgttctg 615301 tcaaaaggga ccattctgcg tgaaaacggc tgtgatttga aggcgtttac aaagacggac 615361 tggcacaaag gcggtcttgt cccgcttgag ctttcatatg atatgacgat ggatgacttg 615421 cagttttcta tgccgatggg cgtgaaaatg cggaatgcgg ttattatgga gccatatatg 615481 attgagatcg acaattcgat ggaacagctc tcgtttgacc atgatgaaag ttatttgacg 615541 atgctcgaca gacacgggaa atggcgcgtc aatacgatga taaaagggtt tgcctcaagc 615601 gtgcagggat ttgtaagctc ctttacgacg acgggcgaca ttgtcgcgat tggaaaaaat 615661 aaagcggata tgctgctcgc tttcgcccgc atgaaagaaa tcggaggagg aattgtttta 615721 gcggagaacg gaaacattct gcatgaaatc ccgcttgcgc tgtgcggctg cgcctcttcg 615781 gaagcgtatg aagacgtgct tgagaaggaa caaaagctga gagatctttt gactgaaaga 615841 ggctatgagt tttgcgatcc tatctatacg ctgctctttt tgcaaagtac gcaccttccg 615901 tatatacgca ttacgccaag aggaatattc gacgtcatga aaaaaactgt actctttcca 615961 tcgataatgc gttaaaatat aaaagagcag ggagccgaca tatgaaaaaa tggatgacag 616021 tttgcgcgct gtgtttcgtg ttttttctgc tggtatcctg ccagcagaag gatgctgtcc 616081 cggatactgc aaagaagctg aaagctcctt taacggggct aaagactgaa cagaaagtga 616141 ctgaacgccg ccctgttgct gttgtggtga acaatcaccc gaaggcgagg ccgcagtcgg 616201 gtctgtctaa agccgacatt gtcatagaag cgctagccga agggcaaatc acaagatttc 616261 tggccatttt ccaaagccag atgcctgaaa ctgtcggacc tgtgcggagc gcgcgggaat 616321 atttcgtcac tctcagcaat ggctttgaca gcatatttgt ccatcacggc tggagtcccg 616381 gcgccaaaaa gcagctggaa tccggagctg ccgattatat gaacggattg gattttgacg 616441 gaagcttatt ttggagagct gatttcagca aaccgcccca caattcctat acgtcttatg 616501 attacataaa aaaggcggca gaacaaaagg gttataagct gaagcaggaa acaaatccgc 616561 tgctgtttca aacatcagat gcaaaacctg caaatgaatc ttacaatgtt cgggtagatt 616621 atggaacaaa taacgttaca aatcttgtcg aatacaacta tgataaaaaa gctgaatttt 616681 atacaagaag ctctgatggt gtcataacga cagaccggga aaccggaaag ccggttgcaa 616741 tgcaaaatat tttcattgtt gaagccagcc atcatattat tgatcaagat ggaaggcggg 616801 acatcgactt ggaatcagga ggaaaaggtc tgttgtttca gcacggaaac gtcattgaaa 616861 cagactggaa acaagtgaat ggcagaattg tgccggtaaa agacggcaag tggcttccgt 616921 ttgtgccagg aaagacttgg atcaatatcg tacctgatct tgatgcggct tccattagta 616981 aaggagaagg tgtgtaacga tgcaaatcga taaattacgc ggcaaagagc tggaccagtt 617041 atttaactcg atcttatcgc tgaaagacct ggaggaatgt taccgattct tcgatgatct 617101 atgcacaatt aacgaaattc aatcgctggc tcagcgcctt gaagtggcgc gcatgcttcg 617161 cgaaggaaac acgtatcata agattgaaac agaaacaggc gcttccacgg ctacgatttc 617221 ccgtgtgaaa cgctgcttaa attacggaaa tgacgcttat gaaatggcgc ttgaccgtgt 617281 gaaggagacg gaaacagagt cttcttccaa ataaaaaacc gccctgccgt ctggcaaggg 617341 cggtttcttt atgaaacaaa ttgatggatc aggttgtcga tattgatgat actgccatcc 617401 tctttccgat agacaacatg ctccttggaa aaatgaatcg gcgaattaat ccctgctgcg 617461 gctgcaaggt taaatagtcc ctcgcgcaat gaaataacgt agttgcagac acgatgctgt 617521 ttttcctcaa cgctcagtgc tttttgcaat ttcggatctg tcgtcgccac acctgccgga 617581 caggtgttgg tgtggcagac gagagcgcgg atgcagccaa cggaaaacat catgccgcgt 617641 gcgatgttaa caaagtcagc gccgagggct aaggcgaccg cgattttatc aggagtcagg 617701 agctttccgg aagcaaagat tttcagctgg ctgcgcaagc cgtactgttt aagaagcgtg 617761 tccacaatag gcagcgctgt cataatcgga aggccgactg tatccgcgag ctcgtaaaag 617821 gaagctccgg taccgccttc acttccgtcg atcgtgataa aatccggatg ctttccgctt 617881 ttctgcatat gagagaaaag ctcatgcaat tcttcaggat gccctgcgac cagtttgatg 617941 ccgactggct tttgtccgac atctctaagt ttttcaataa agtcgagcat ttcaggaggg 618001 tttgagaatt cataaaagcg gttcgggctg tcaatcgact ttccaggttc gacattccga 618061 atgtctgcca cttcctctga tactttggcg ccgtccacat ggccgccgcg ggttttcgct 618121 ccttgtgcca gctttagctc aaacgcttta atctggtcaa tcctgctttt tcttttaaat 618181 tcctcccacg aaaattcccc gtttcttttg cgcacgccga ataggcccgg tccgatttgg 618241 caaatgatat cggcgccgcc ctttaagtga tattcagaca atcccccttc acctgtattc 618301 atccaggtgc cgcctgccag atggagccct tttgagagcg ccgtaacagc ccgttctcca 618361 agagaaccgt agctcatggc agactggccg actaagccct tcacataaaa tggcttctcg 618421 catgtatgct cgccaatcac ctgtacatca tcaggatgga gaaaatacgg gtctgccttg 618481 atatgttcgg catgctcctt gcgtttgaac agattgtcag catccatttt atagatttgg 618541 gtttcaattt ttggcgtttg atttacatgc atttcttccc tttgttttgg aaacatagcg 618601 ttacggatat aatagccagg tttatcaaaa tctcttacag atccaaagcc catcattctg 618661 cttttgtatt tgccggagat gacggtttgc tcatattcct ttcgtgaaaa tggctgctct 618721 tcattgtcat tgctgtataa atactgtctg agctccggcc cgattttttc aaggatatac 618781 cgaaaccttc cgatgacggg atagttgcga agaattgagt gctcctgctg tttttcatcc 618841 tttatgtaga tccaggcaaa caagacgatc gggatagcga tgatcccaat gataaatgcg 618901 atgagtgcta ttatgatggt ttccatctct cagcctccct ttttatgtaa ccatttccac 618961 agtagaacac tttccaaaca atagcagaag gaatctggtg aaaaatgtgt gctcctgccg 619021 atacaggact caccatgcag gtactgccat atgctctctt tttttatgaa aaaagaatca 619081 aaacaccttt ttcagtgaat aacgagatta acggcttttt ccgtttttcc gcgctatgtg 619141 aatttgttat aatgtttaaa tggtaacaaa cgaatggagg aacgtatgac gtgtacgatg 619201 taacggagtg gaagcatgtc tttaaactcg atccaaataa agatttgcct gacgaacagc 619261 tggagattct ttgcgaatca ggaacggatg cggtcattat cggaggaagc gatggtgtga 619321 cagaggataa tgtcctgcgg atgatgtcta aggtaagacg gtttttggtg ccgtgtgtcc 619381 tagaggtatc agcgattgaa gcgattgttc ccggctttga cttatatttt attccgagtg 619441 tattaaacag caaaaacgcg gattggattg tcggaatgca ccagaaagcc atgaaggaat 619501 acggagaact gatgtctatg gaagaaatcg tggcggaggg ctactgcatc gcaaatccag 619561 attgcaaagc cgcggcactg actgaagcgg acgccgatct gaatatggat gatattgtcg 619621 cctatgcgcg tgtgtcggag ctgctgcaac tgccgatttt ttatttagaa tacagcggcg 619681 tgcttggaga catagaagct gtcaagaaaa cgaaggctgt attggaaacg tccaccttgt 619741 tttacggcgg cggcatcaag gatgcggaaa cggccaagca gtacgcagag catgcggacg 619801 tgatcgttgt aggcaatgcg gtgtatgaag attttgacag ggctttgaaa acagtagcgg 619861 ctgtgaaagg cgagtagtaa attgtacgga tttggtttat gatagaacgt atgttttgta 619921 taggcgggtg aacaaatttt gaattatatt agcaatcaat tactaagcgg tttaaacccc 619981 gttcagcagg aagcagtcaa aacaacggac gggcctcttt tgctgatggc gggagcgggt 620041 agcggaaaga cgcgtgtcct gacccataga attgcttatt taatggcaga aaagcatgtg 620101 gcgccgtgga acattctggc gatcacattt acaaataaag cggcacgcga aatgaaagaa 620161 cgtgtggaaa gcatcctcgg acccggcgcg gacgatatct ggatctccac attccacagc 620221 atgtgcgtgc ggatcttgcg cagagatatc gaccggattg ggatcaaccg aaatttctcc 620281 atccttgata cggctgacca gctttcagtg atcaagggga ttttgaagga gcgcaatctt 620341 gatccgaaga agtttgaccc gagaagcatc ctcggcacga tcagcagtgc aaaaaacgaa 620401 ttgaccgaac cggaggaatt ctctaaagtt gctggcggct actacgatca ggtggtcagc 620461 gatgtatatg ctgattatca gaagaagcta ttgaaaaacc agtcgctcga tttcgacgat 620521 ttaattatga cgacgattaa actgtttgac agagtgcctg aagtgcttga attttatcag 620581 cgcaaattcc agtacatcca cgttgatgag tatcaggata cgaacagggc acaatacatg 620641 ctcgttaagc agcttgccga gcgtttccag aacctttgcg ttgtggggga ttctgatcag 620701 tcaatctaca gatggcgcgg cgcggatatc accaacattc tttcatttga aaaagattat 620761 ccgaatgcaa gcgtgatttt gctagaacaa aactatcgtt caacgaaacg gattttgcgc 620821 gcggctaacg aggtcattaa aaacaactct aaccgcaaac cgaaaaattt gtggacggaa 620881 aatgatgaag gcatcaagat ttcctattat cgcggtgata atgagttcgg tgaaggacag 620941 tttgtggccg gcaaaattca tcagcttcac agcacaggca agcggaagct gtcggatatc 621001 gccatattat accggacaaa cgcgcagtcc cgtgtgattg aggaaacgct tctcaaagcg 621061 ggcttgaact ataacattgt cggcggcaca aagttctatg acagaaaaga aattaaagac 621121 attcttgcgt acctgcgcct cgtatccaat ccggatgacg atatcagttt cacgcgcatt 621181 gtcaatgtgc cgaagcgcgg agtcggcgcg acatcacttg aaaaaatcgc ttcgtatgcg 621241 gccataaacg gcttgtcctt tttccaagcg attcagcagg ttgattttat cggcgtcagt 621301 gccaaagcgg caaacgcgct tgacagcttt agacagatga ttgaaaacct gaccaatatg 621361 caggattact tatccattac agagctgaca gaagaaattc ttgataagac ggaatacaga 621421 gaaatgctga aggctgagaa atcgatcgaa gcccaaagcc gtttagaaaa tatcgacgag 621481 ttcctgtctg ttacgaaaaa ctttgaacag aaaagtgaag acaagacact cgttgcgttc 621541 ctgacagact tggcattgat cgcagatatt gatcagctcg atcagaagga ggaagagtca 621601 ggcggcaagg atgcgatcac cctgatgaca ctgcacgccg cgaaaggact ggagtttccg 621661 gttgttttct tgatggggct tgaagaaggc gtcttcccgc atagccgttc actcatggag 621721 gaagcggaaa tggaagaaga acgccgcctt gcgtacgttg ggattacaag ggcggaacag 621781 gagctttatc tgaccaatgc taaaatgcgc accttgtttg gccggacaaa tatgaacccg 621841 gaatctcgct tcattgctga aataccggat gatttattgg aaaacctaaa tgagaaaaaa 621901 gaaacaagag cgacgtctgc gagaaaaatg cagccgagac gcggccctgt ttcacgcccg 621961 gtatcctacg ccagcaaaac aggcggcgac accttgaact gggcagtcgg agataaggcg 622021 ggccataaaa aatggggaac aggaactgtc gtcagcgtga aaggcgaagg agaagggaca 622081 gagcttgata ttgccttccc gagccctgtc ggcgtgaaac gcctgttagc agcatttgct 622141 cctattgaaa agcagtaatt gaagaggaaa ggaagaagca gatggacaaa gaaacagcga 622201 agcagcgggc agaagaactg cgccgcacca tcaacaagta tagctatgaa tattacacct 622261 tagatgaacc gagcgtccca gatgccgaat acgacagatt gatgcaggag ctgatcgcga 622321 tcgaggagga gcacccagac ctcagaacgc ctgactctcc tacgcagcgc gtcggcggag 622381 ccgtgcttga agcgtttcag aaagtcaccc acggcacacc gatgctcagt ctgggcaacg 622441 cctttaatgc tgatgatctt cgtgatttcg accgccgtgt gcgccagtcc gtcggcgacg 622501 atgtggcgta taatgtggag ctgaaaatag acggtcttgc tgtttctctc cgttatgaag 622561 acggctattt tgtcagaggg gccacaagag gtgacgggac gacgggagag gatatcacgg 622621 agaatctgaa gacgatccgc aatatccccc ttaaaatgaa ccgtgagctg tcgatcgaag 622681 tgcgcggcga ggcgtatatg ccgaagcgtt cgtttgaagc actcaatgag gaacggatta 622741 aaaatgagga agaaccgttc gccaatccgc gaaatgccgc ggcgggatct ctcagacagc 622801 tcgatccgaa aattgcagcg aaacgaaacc tcgatatctt cgtctacagt atagcggagc 622861 ttgacgagat gggtgtagag acgcaaagcc aagggcttga ttttctcgac gaactcggat 622921 ttaaaacgaa tcaggaacga aaaaaatgcg gcagcataga agaagtcatt acgctgatcg 622981 atgagcttca ggcgaagcgc gcggacctgc cgtacgaaat agacggcatt gtcattaaag 623041 tcgattctct cgatcaacag gaggagctcg gttttacggc gaaaagcccg cgctgggcca 623101 tcgcgtataa gtttcctgct gaagaggtcg tgacgaagct tctcgatatc gaattaaatg 623161 tcggcagaac gggtgtgatt acgccgactg cgattcttga gccggtaaaa gttgccggca 623221 caacggtctc aagagcatcc cttcataacg aagatttaat taaagagaag gacattcgga 623281 ttttggataa ggttgtcgtc aaaaaagcgg gcgatatcat cccggaagtt gtgaatgtcc 623341 tcgttgacca gcgcacagga gaagaaaagg aattcagcat gccgacggaa tgtcctgaat 623401 gcggcagtga actcgtccgg atcgaaggag aagtggcgct tcgctgcatt aaccctgaat 623461 gtccggcgca aatccgggaa gggcttatcc atttcgtttc ccggaatgcc atgaacattg 623521 atgggctcgg cgaacgagtg atcacacagc tgtttgagga aaaccttgtc cgcaatgtgg 623581 cagatttata taagctgacg aaggaacgag tcatccagct cgagcgcatg ggcgaaaagt 623641 ccactgaaaa cctgatcagc tccatccaaa aatcaaaaga aaattcgtta gagcgcctgc 623701 tgtttgggct tggcatccgt tttatcggat caaaggccgc aaagacgctt gccatgcatt 623761 ttgaaagctt ggagaacctg aaaaaagcct ctaaagagga acttctcgcg gtagatgaaa 623821 tcggtgaaaa aatggctgat gctgtgatca cctattttca taaagaagaa atgcttgaac 623881 tcttgaatga acttcaggag ctgggcgtaa acacgctcta caaaggcccg aaaaaagtaa 623941 aagcagagga cagcgactct tactttgctg gtaaaacaat tgttctgaca ggaaagctgg 624001 aagagctgtc aagaaacgaa gccaaagcgc aaatcgaagc gctgggcgga aagctgactg 624061 gaagcgtcag caaaaacaca gacttagtca tcgccggaga agcggcggga agcaagctga 624121 caaaagcaca agagctgaac attgaagtgt ggaatgaaga acagttaatg ggagagctaa 624181 agaaataaga ggagtgtttt ctattgaaaa agacgttggc attggcggca acggcggcag 624241 tattaatgct gtctgcctgc tcgtcaggtt tcggggggga gaaggaggaa gagattacgc 624301 aaaagacggc gaaatcgtca gaaaaagcga ttgtcccgaa atataatatc tctgactcct 624361 attacaaaat ggtgctgccg tttaaggcag gcaaagcgcg cggcttaaca acggaacagc 624421 tgaatacaag gctggacatt gacgaatttg aaacagggct gatgcgcctt gcccaagatt 624481 ctttctcaac tgacgattat ctgttccaag aaggacaata tttagatgag gatacagtat 624541 taagctggct ggcacggaaa aaaacgggct ctgatttgaa aaaagccgaa aaagaagata 624601 agaacttcaa aaatgaaggc ttgaacccgg cgctcccgag ttctggttca acagaagaaa 624661 agaacgaaag cagcccaatt tatttagcat ccatgcttga gcacgattat ttagtcagaa 624721 aagacaagaa ttctatccag cttggcggcg tcatgatcgg actggcgtta aactcagtgt 624781 attactatcg tgaaaaaact ggcgacccgc aaaaagaagt ggagattaaa gacagcacgc 624841 ttcgccagca gggagaaaaa attgcacagg aggttattaa ccgcctccgc aaaaaagata 624901 acttgaagaa tgtgccgatt accgtggcgc tctacaagca ggcgtcaaaa acatcgattg 624961 tgccggggaa cttcatcgcc aaaacagagg tcaaagcagg ctctactgat atctcaaatt 625021 gggatgacat caatgaaaaa tatgtattct atccggcgga tacaaccaca gcagaaaagt 625081 acccggatga caccgaggtc tttaagcggt tcaaaaactc aattgaagaa tatttcccga 625141 actatacagg cgttgtcggt acagcgctgt atgaaaatga tgaaatgaag aaaatgaaga 625201 ttgacatacc aatgcaattc tacggaaaaa gtgaagttgt cgcgtttacc cagttcttaa 625261 cgggtgaagt gatggactac tactctaaga gctcagttga tgtcgaagtc aatatcacgt 625321 cctcagacgg acaggaagcg gtcattatcc gcaatgccgg agataaagag ccgactgttc 625381 acatttatga ctgatagaaa acccttgtgc catattggca caagggtttt tatgttacaa 625441 ttaacaggaa aagggaaaat attttcactt ctgccgaaac acaaatcaag gggaggtatg 625501 ttgatgctgg aaatcgtgtg aaaacaatca ttatcaaatc tatagcaatg aaaggatgtt 625561 agacgtgcat aaagatatca aaaaaatatt tcatgaagag caggttttgg cagaagctgc 625621 agcgagatac ggtttctcaa aagatcaggt gcgttttctg gctgatgcgg aaaactatgt 625681 atatgaatgt atgaaagaca atcaacctta tattttaaag attacccata cgattcggag 625741 atcttctgat tatatgatgg gagagatgga atggctccgt caccttgcaa tagggggaat 625801 ttcagtagcc aaaccgctcc cgtcgctgaa cggaaaagac gtagaagcag tgccggacgg 625861 aaacggcggg tcatttttat tgagagtgta tgagaaagcg ccggggcaaa aagtggatga 625921 atcggactgg aatgaaacgc tattttatga gcttggcaga tacacaggca gcatgcacag 625981 cctgacaaaa agctacaaat tgagcaatcc cgctttcaaa agacaggaat gggatgaaga 626041 ggagcaatta aagctgagaa aatatgtgcc tgaagatcag ataaaggtgt ttcagcaagc 626101 cgattctttg atgaatgaac tgcggaggct cccgaaaagc caggacaact acggcttggt 626161 gcatgcggat ctgcaccatg gcaattttaa ctgggatcat ggcaaaatca cggcatttga 626221 ttttgatgat atcggctaca actggtttgt taacgatatt agcattcttc tctacaatgt 626281 cctgtggtat cctgttgtgc catatgatga taaagctgcg tttacagaag aatttatgac 626341 gcattttatg aaagggtact gggaggaaaa tgagcttgac cctgcatggc tgatgataat 626401 acctgatttc ctccgccttc gccatatgct gatttacgga ttgctgcatc agatgtttga 626461 ccttaacaca ataggagaag aggaaaaaga aatgctggcc ggtttcagaa gagatataga 626521 gaatggcacg ccgattacag catttgattt ttcagcactg gtgtagatag aaaaagccaa 626581 tgggattcca gtcccattgg cttttataat gtatcacact tcacgccgac tacgccttca 626641 atggctttaa tgtcatagta gacatcggtc gtgtatctgt ttttatggac gcggaccttc 626701 acttccataa ttggaaaatc cttttcgcct aggtcgtcga tccgaacgga gtgtgctttg 626761 atatctcttc ttttcatttc ttttaaaatc tctgtcattt tgtctttatc agaaagtgac 626821 attctgatgc ggatgtcttt ttcctgcagg cggtcggggc cgatttttct gaccacccat 626881 gggagaaatt ccacactgat caggatgaac agaagactgg caaacgcttc tttataaaaa 626941 ccggctcccg tagcaagccc gagccccgct gccccccaga tcatggccga tgtcgtcagg 627001 ccggaaatga catcattgct ttttcgcagg atgacaccgg cgccgataaa cccgacgccg 627061 gagatgattt gtgccggcag acgaagcgga tccatcatga tgcggtagta tttagggaaa 627121 tgatatgccg cattaatact gacgatcgtc agcatgcatg agctgactgc gatgacaata 627181 caggttttta atccgagcgg cttatttttt aattcgcgtt caagcccgat gaccatgcca 627241 atcaatgtgg caatgcccaa tttcaataaa atatcaggat caatatacca gctcaacagc 627301 aaacttcccc cttctctatg gtgtttttaa ataaatatga ttttctcaca gtatttatag 627361 caaaacaaga gcacaaaagc caccaagctg cgcttgatgg cttattgctt actttttgcg 627421 ttttaacagc ttttccatga caccgaataa tcggtaagag gcttttgcag gacgttttgt 627481 gatcatgctg acaatgatgc cggcaatcat actgagaata aacccaggga tgatttcgta 627541 cacaccggtt gattttgcca ggccggttgt aatccagatc aacacggtcg cagccccgac 627601 aatcatggca gcaagcgcgc cccattcgtt cattcgtttc caatacagac tgagcagaat 627661 cgcaggcccg aaagctgaac cgaagccggc ccaagcgtat ccgaccaaat caagaatggt 627721 gctgttcggg ttcaatgaca agagtaccgc gataacggca atgactaaga cggacaatcg 627781 cccgatcatg accaattctt tatcagaagc ttttcgtctg aaaaatgacc ggtataaatc 627841 ctctgttaca gcacttgctg tgaccaagag ctgtgaggaa atcgaactca tgatggcagc 627901 caaaatagct gacaataaga accctgtaat taatgggtgg aacaagattt tagagaagat 627961 aatgaaaatc atctccggat cttttacagc aactccgaat ttatgggcgt atgcaacacc 628021 gattaaaccc gtcagcacgg aacctagaac tgtaatgatc atccagctca tgccgattcg 628081 gcgtgcaggt tttaaatctt taatgtcttt aatggccata aatcggacga tgatatgagg 628141 ctggccgtag tagcccaacc cccaggctaa ataggaaata atgctaatga cgctcgcgcc 628201 tttaaaaata tccaataaat gtggattaac agcgtcgatt tcatggaaag tcggagcaac 628261 gccgcccaca tgggtaaaag caacgatcgg cacaagcact agtgctgcaa acatgatcgc 628321 accctgcacg aagtcagtca gactgacagc aaggaaaccg ccaaacagtg tgtataacac 628381 gacaactgcg gtggtcagaa acaggcctaa tttgtaatcc gcaccaaaag cagattcaaa 628441 cagccgtccg ccagatacca taccggaaga ggtatacaat gtgaaaaaga tcatgatgat 628501 caatgcagat acgattttca gcagtgatga agaatgctgg aatcgtttat caaagaaatc 628561 aggaattgta atcgcatcat ctgccgcttc tgtataagca cgcagccttg gagccagcag 628621 caagtaattt gagtacgccc cgattgtaag acctaaagca agccataagg tggacagccc 628681 tgtcgcaaac atcgcgccgg gaacacccat cagcatccat ccgctcatat cggccgcgcc 628741 ggcagacaaa gcagtaacga atggtccgag gcctcttcct ccaagcatgt aatcattgat 628801 gtcagtggtt ttcttgaatg cataccagcc gattaacagc atggcaataa agtaaattcc 628861 taaagatata ataatttcaa tactcacgtt ttaccctctc ttcatttcta ataatgttgc 628921 atcacctctc aaattgatgg tgccagttaa gcagcctggc gtaagtgcaa aacaaaagaa 628981 attcttttgc gggtgcactt ggtaacttaa cctaacaaag tattcccggc cattcaagcg 629041 atgaaacatt gatcataagc tggaaatacc gttgcaaacc tagaagggaa taaagaataa 629101 aacgctttca aaaaataatt aaagtaaaaa tattcagaaa aatatttcgt ttctccttct 629161 cctcatttta gtataaaata tatagggtat tgtttcgaaa acacaggcct gtctcaaggc 629221 gttttgttgc tttaaagggc ttgtttttga tatgatcagt attatatgac ttaacggaga 629281 aatatgtgga ggtggatcat atgtcacgaa tttcaataga agaagtaaag cacgttgcgc 629341 accttgcaag acttgcgatt actgaagaag aagcaaaaat gttcactgaa cagctcgaca 629401 gtatcatttc atttgccgag gagcttaatg aggttaacac agacaatgtg gagcctacaa 629461 ctcacgtgct gaaaatgaaa aatgtcatga gagaagatga agcgggtaaa ggtcttccgg 629521 ttgaggatgt catgaaaaat gcgcctgacc ataaagacgg ctatattcgt gtgccatcaa 629581 ttctggacta aaggagggac acaagaatgt cattatttga tcataaaatc acagaattaa 629641 aacagctcat acataaaaaa gagattaaga tttctgatct ggttgatgaa tcttataaac 629701 gcatccaagc ggttgatgat aaggtacaag cctttttggc attagatgaa gaaagagcgc 629761 gcgcatacgc gaaggagctt gatgaggcgg ttgacggccg ttctgagcac ggtcttcttt 629821 tcggtatgcc gatcggcgta aaagataata tcgtaacaaa agggctgcgc acaacatgct 629881 ccagcaaaat tctcgaaaac tttgatccga tttacgatgc tactgtcgtt cagcgccttc 629941 aagacgctga agcggtcaca atcggaaaac tgaacatgga cgaattcgcc atggggtcat 630001 ctacagaaaa ctcagcttac aagctgacga aaaacccttg gaacctggat acagttcccg 630061 gcggttcaag cggcggatct gcagctgcgg ttgctgcggg agaagttccg ttttctcttg 630121 gatctgacac aggcggctcc atccgtcagc cggcatcttt ctgcggcgtt gtcggattaa 630181 aacctacata cggacgtgta tctcgttacg gcctggtcgc atttgcgtct tcattggacc 630241 aaatcggacc gattacacgt acggttgagg ataacgcgtt tttacttcaa gcgatttccg 630301 gcgtagacaa aatggactct acgagtgcaa atgtggacgt gcctgatttt ctttcttcat 630361 taactggcga catcaaagga ctgaaaatcg ccgttccgaa agaatacctt ggtgaaggtg 630421 tcggcaaaga agcgagagaa tctgtcttgg cagcgctgaa agtccttgaa ggtctcggcg 630481 ctacatggga agaagtgtct cttccgcaca gtaaatacgc gcttgcgaca tattacctgc 630541 tgtcatcttc tgaagcgtca gcgaaccttg cacgctttga cggcatccgc tacggctacc 630601 gcacagacaa cgcggataac ctgatcgacc tttacaagca aacgcgcgct gaaggtttcg 630661 gaaatgaagt caaacgccgc atcatgctcg gaacgtttgc tttaagctca ggctactacg 630721 atgcgtacta caaaaaagcg caaaaagtgc gtacgttgat taagaaggat ttcgaggacg 630781 tatttgaaaa atatgatgtt attgttggac cgactacacc gacacctgcg tttaaaatcg 630841 gtgaaaacac gaaggatccg ctcacaatgt acgcaaacga tatcttaacg attccggtca 630901 accttgccgg cgtaccggga atcagtgtgc catgcggatt agcagacgga cttccgctcg 630961 gcctgcaaat catcggaaaa cactttgatg aaagcactgt ataccgcgtt gctcatgcat 631021 ttgaacaagc aacagaccat cataaagcaa aacctgaact gtaaggggtg aaaagaattg 631081 aactttgaaa cggtaatcgg acttgaagtc cacgttgagt taaaaacaaa atcaaaaatt 631141 ttctcaagct ctccaacgcc attcggcgcg gaggcgaata cgcagacaag cgttattgac 631201 ctcggatatc cgggcgtcct gcctgttctg aacaaagaag ccgttgaatt cgcaatgaaa 631261 gccgctatgg cgctcaactg tgagatcgca acggatacga agtttgaccg caaaaactat 631321 ttctatcctg acaacccgaa agcgtatcag atttctcaat ttgataagcc aatcggcgaa 631381 aacggctgga tcgaaattga agtcggcggc aaaacaaaac gcatcggcat cacgcgcctt 631441 catcttgaag aggatgccgg aaaactgacg catacgggcg acggctattc tcttgttgac 631501 ttcaaccgtc aaggaacgcc gcttgttgag atcgtatcag agccggacat ccgcacgccg 631561 gaagaagcgt acgcatatct tgaaaagctg aaatccatca tccaatatac aggcgtttct 631621 gactgtaaaa tggaagaagg ctcacttcgc tgtgacgcca atatctctct tcgtccgatc 631681 ggccaagagg aattcggcac aaaaacagaa ttgaaaaact tgaactcctt tgcgtttgtt 631741 caaaaaggcc ttgagcatga agaaaaacgc caggagcagg ttcttctttc cggcggcgtc 631801 atccagcaag aaactcgccg ttatgatgaa gcaacgaaga aaaccattct tatgcgtgtc 631861 aaagagggat ctgacgacta ccgttacttc ccagagccag atctagtcga gctctacatt 631921 gatgatgaat ggaaggaacg cgtaaaagca agcattcctg agcttccgga tgagcgccgc 631981 aagcgttata tcgaagagct tggcttgcct gcatatgacg caatggttct gacgctgaca 632041 aaagaaatgg ctgatttctt cgaagaaacc gttcaaaaag gcgctgaagc taaacaagcg 632101 tctaactggc tgatgggtga agtgtcagct tacctaaacg cagaacaaaa agagcttgcc 632161 gatgttgccc tgacacctga aggccttgcc ggcatgatca aattgattga aaaaggaacc 632221 atttcttcta agatcgcgaa gaaagtgttt aaagaattga ttgaaaaagg cggcgacgct 632281 gagaagattg tgaaagagaa aggccttgtt cagatttctg acgaaggcgt gcttctgaag 632341 cttgtcactg aggcgcttga caacaatcct caatcaatcg aagactttaa aaacggaaaa 632401 gaccgcgcga tcggcttcct agtcggacag attatgaaag cgtccaaagg acaagccaac 632461 ccgccgatgg tcaacaaaat tctgcttgaa gaaattaaaa aacgctaata aaaaagcagc 632521 ccttagaggc tgcttttttt atggtcaaat tgagataaag acaagatgag ggcccgaagc 632581 ctttcaactt ctttgtcgtt ggttccggcc aaattggaca gcatgccttt aataatcggc 632641 ttgcgcggtt tatcctgagt caattcttcc tcgataacat caagtgacac ggtgatatcc 632701 tcgggcagcg tgctgttttc tttcactttc tgaatgtcct caagcagctg gtcttttccc 632761 gcaggcatcg ggttaaaaat gtcttttgat acaatcggat tgagtgcaga acggctcagc 632821 ccctgtacaa gatcatccag tctctcaata ataaaggctg agatttcttc tgcatcgata 632881 ttaagctcac cgttaaatac catcacgttc atataggaat gcacaatgcc tcttgccatg 632941 atggacagat ctgcgacata ccgctcgatt ccttcgccat aggataccag caaggcgttc 633001 cggtacagct tatccgtctc catggttact ttgtaaaagt attgcttgat ttcttgattt 633061 tccggaatga tattttcggt aagcaaaaga acgataaaat ctttatgatc gcgaaaatcc 633121 tcaaattgag cgccaatttg cttttttaac acttccttag gcggctttcc ggcgagatct 633181 tcttctatat ttttcatttt gttcatagac ataccgatat aatattcaca ggcagataac 633241 agcagcgctt ctttcgattt gaagtgcaaa taaaaagcgc ccttcgaaat gccgcattca 633301 ctggcgattt cttggatcgt cgtagctgcg aatccttttt tcgcaaataa acgaatgctg 633361 gtttttatga ttctctcttt tttttcattc atgacgtgct tccccttaat ccttgaaaaa 633421 tttagtaaaa ttttctggta tatgagttga cgttgttgcg ttataacgtt tagtattata 633481 tagaatgacc agtcagtcaa taaaaaatgt aatggaggat atgatgaacc acgttattaa 633541 tttcgttctg aaaaacaaat tcgccgtatg gctgatgacg attattgtaa cggcagccgg 633601 cttgtatgcg ggtatgaata tgaagcaaga gtctattcct gacgtgaaca tgccttactt 633661 gacgatcagc acgacatatc cgggtgcaac accaagccaa gtggctgatg aagtgaccaa 633721 accggttgaa caagccgtac agaacttgga cggtgtcagc gttgtgacgt cgacgtccta 633781 tgaaaacgca tcgtcggtca tgattgaata tgattatgag aaagatatgg acaaagcgaa 633841 aacagaagca gctgaagcgt tagaaaacgt caacctgcct gatgacgcga aggatccgga 633901 gatttcacgc tacagcttga actcattccc gattctgacg ctgagcgtgt ccagtgataa 633961 agataatctg caagagctga cgaaacaagt ggaggacagc ctcgtttcta agcttgaagg 634021 catagaaggc gttgcgtccg tccaagtatc aggccagcag gtggaagagg ttgaattctc 634081 tttcaaagaa gacaaactga aggaatacgg ccttgatgaa gatacagtca agcaagtgat 634141 tcaaggttca gatgtgacaa ctccgcttgg attgtacaca ttcggaaatg aagaaaaatc 634201 tgtcgtcgtc agcggcgata ttgaaacaat taaagatttg aagaatatga gaatcccgac 634261 ggcatctgct tcaagtgcag gcagcagcgc agcatctcaa gcaggtgcgc agagtgctca 634321 agcagcccaa agcgcgcaag cggcagcaca ggtgcagcaa agcgcaagca cagcagtgcc 634381 gacggtcaag ctttctgaca ttgctacaat taaagatgtg aaaaaagctg aatccgtttc 634441 acgcacaaat ggcaaagaca gcatcggcat caacatcgtc aaagcaaacg atgcgaatac 634501 ggtagaggtt gccgacgatg tcaaagctga gctgaaaaag ttcaaagaag accataaagg 634561 cttcaattac agcgcaactc tcgacatggc ggagccgatc acacagtcag ttgacacgat 634621 gttaagcaaa gccatcttcg gtgctatttt tgcgattgtg attattctct tattcttaag 634681 agatatcaaa tcaacattaa tttctgttgt ttcaattcca ttatcattgc tgatcgcact 634741 ccttgtgctg cagcagcttg atatcacatt gaatattatg acgctcggcg caatgaccgt 634801 tgccatcgga cgtgtagtcg atgactccat cgttgtgatc gagaacattt accgccgcat 634861 gagactcaaa gatgagccgc tccgcggaaa agccttggtt cgtgaagcga cgaaggaaat 634921 gtttaaaccg atcatgtcat caacgattgt gacaatcgcg gtattcctgc cgctcgcact 634981 tgtaggcgga caaatcggtg aattgtttat tccatttgcc ttaacgattg tttttgcgct 635041 tgccgcatcc ctagtgattt caatcacgct tgtgccgatg ctcgcacaca gcctgttcaa 635101 aaaatcatta accggtgcgc cgattaaagc gaaagaacac aaacctggca gacttgcaaa 635161 catctataaa aaagtattga actgggcgct gagccacaaa tggatcacgt ctatcatcgc 635221 ggttctgatg ctccttggaa gcttgttcct cgtaccgtta atcggtgcca gctacctgcc 635281 gtccgaggaa gaaaaaacga tgcagctcac atacagccca gaaccgggtg aaacgaaaaa 635341 agaagccgaa aatgaagctg aaaaagcgga aaaaatcctg cttgaccgca agcatgtcga 635401 tacggttcag tattcattag gctctggcag cccgcttgcc ggaggagatt ctaacggtgc 635461 gttattctat atcaaatatg aaagcgacac acctgacttt gataaagaaa aagataacgt 635521 tctgaaggaa atccaaaagc aatctgaccg cggagaatgg aagtcacagg acttcagctc 635581 ttcaggcaat aataacgaat taacatacta tgtgtatggc gattctgaaa acgatattaa 635641 agacacggtc aaagacattg aaaaaatcat gaaagatgaa aaggatctga aaaacgtaaa 635701 ttcaggcctt tccagcacat atgatgagta cacatttgtc gctgaccaag aaaaactaag 635761 caagctcggt ttaaccgcgt ctcaaatttc tcaggcctta atgtcacaaa catcgcaaga 635821 accgctcacc actgtgaaaa aagacggcaa agagcttgat gtgaacatta agacagaaaa 635881 agacgagtat aagagtgtga aagatttaga gaataaaaag atcacttccg cgactggcca 635941 ggaagtcaaa atcggcgatg tggcaaaagt gaaagaagga tcaacatcag ataccgtgtc 636001 aaaacgtgac ggaaaagtct atgcagatgt cacaggtgag gttacctctg acaacgtcac 636061 agccgtatca gctgctatcc agaagaaaat cgataagctt gaccaccctg ataacgtatc 636121 gattgacaca ggcggcgtat cagcggatat cgctgattcc ttcacgaagc tcggtttagc 636181 gatgctggca gcaatagcga tcgtttacct tgtgctcgtg attaccttcg gcggagcact 636241 agcgccattt gcgattctgt tctcattgcc gttcacagtc atcggtgccc tggtcggact 636301 ttacgtatca ggtgaaacga tcagtctgaa cgccatgatc ggtatgctca tgctgatcgg 636361 tatcgttgtc acgaatgcca ttgtcttaat tgaccgcgtg attcataagg aagcggaagg 636421 cctgtctacg agagaagcgc tcctggaagc cggctctaca cgactccgtc cgatcctgat 636481 gacagccatt gcgacaatcg gcgccttgat tccattagcc ctcggcttcg aaggcggaag 636541 ccaggtcatt tcaaaaggac tcggcgtaac ggttatcggc ggtttaatca gttcaacgct 636601 tctgacgctc ctgatcgtgc caatcgtata tgaagtattg gcgaagttcc gcaagaaaaa 636661 accgggaacg gaagaagagt aaaaaacaaa aagcctcagc tctgctgagg ctttcagctt 636721 gttgaaaaac cctcgcattc gttgtcaggt ctgcgcgtcg gtgctcacga attctacatt 636781 cgctccgctc caatgctccc ccttcctaga ctacaagggt tttcaatcaa gctgaaagaa 636841 tgttaaggat gacaaaagct caaaacaaga atcagttttg agcttttgtg cgttttcacc 636901 tgtaagatta tgtacatttt gttgcgattt ttttaactca tagtataatt aaaggttgtt 636961 agtgtaaaaa tggatcggat actcttaagt aggatgatga gataatgaaa cgtgcacgca 637021 taatatacaa tccgacttca ggacgggaga tctttaaaaa gcatcttgcc caggtcctgc 637081 aaaaatttga acaagccggc tatgaaacct ccacccatgc gacgacatgc gcaggagacg 637141 ctacacacgc tgccaaggaa gcggcattgc gtgagtttga cctgatcatt gcggcaggcg 637201 gagacggaac gatcaacgag gtcgtcaacg ggcttgcgcc tttagacaat cgtccgacac 637261 tcggtgtgat tcctgtcggc acaacgaacg acttcgccag agcgctcgga atcccacgcg 637321 aggatatttt aaaagcggca gatacggtca ttaacggcgt tgcccgcccg attgatatcg 637381 gacaggtcaa cggccagtat tttatcaata tcgccggcgg aggccgtctg acggagctga 637441 cgtacgacgt gccaagcaaa ctgaaaacaa tgctcggcca gcttgcttat tatttaaaag 637501 gaatggaaat gctgccttca cttcgtccga cagaagtcga gattgaatat gacggcaagc 637561 tgtttcaagg tgaaatcatg ctgtttttgg tcacgctgac aaactccgtc ggcgggttcg 637621 aaaagctcgc gccggattcc agcctgaatg acggcatgtt tgatttgatg atactaaaga 637681 aagcaaacct tgctgaattt atcagggtcg ccacgatggc gcttcgcgga gaacacatca 637741 acgaccagca cattatttat acaaaagcga accgcgtgaa agtcaatgta tcagaaaaga 637801 tgcagctgaa cctggacggc gagtacggcg gcatgctgcc gggcgaattc gtgaatctgt 637861 accggcacat tcacgtcgtc atgccgaagg agaaagcgga acagttggat gactaaaact 637921 tggcttggta agccaagctc agaatgttga caaaatccta aaacagtttt cgttttagga 637981 ttttgtcatc ttttcagcgt gattgaaaac ctttgaagtc taggaagggc gagcatcgga 638041 gcacagcgaa tgttgaattc gtgagcaccg aagcacaggc ctgacaacga atgcgaaggt 638101 ttgcctacac gctgaaactt ggcttgaata ggccaagttt ttctttcgct taaaactaga 638161 ggtgattata gatgaaaatg aaacccccag tagaaaaaaa tgaatactac gatgtgacat 638221 ttgaggattt gacacatgaa ggagcgggcg tcgcaaaggt ccaaggcttc ccgatctttg 638281 tgccgaatgc cctacccgag gaaaaagccc aaatcaaagt gacacgcgtc aaaaaagggt 638341 tcgccttcgg ccgcctgatt gagctgaagg aagaaagccc gcatagaacg gacgccccat 638401 gcccgattta caaacaatgc ggaggctgcc agcttcagca catgacctac gaaggccagc 638461 tcctgtttaa acagaaacaa gtcaaagacg tcttagaacg catcggcaag ctggaccttt 638521 caaaagtcac cgtgcacccg acactcggca tggaagaccc gtggaactac agaaacaaag 638581 cacaggtgcc ggtaggagaa cgggaaggcg gactcgtcgc gggattctat cagcaaagaa 638641 gccatgacat catcgacatg agcgcctgcc tgatccagca atccaaaaac gacgaagccg 638701 ttcaagctgt caaagacatt tgcgcaaact acggtgtcaa agcctacaac gaagaacgcc 638761 acaaaggctg gctccgccac atcatggtca gatacggcgt tgttacgggc gaaatgatga 638821 tcgtcttcat cacaagaaca agcgacttcc cgcacaaagc gaagatcatc gaagacatca 638881 cagcgcaatt cccgcacgtc aaatccatcg tgcaaaacat caacccaaac aaaacaaacg 638941 tcatttttgg caacgaaaca aacgtcatct ggggcgaaga atacatctac gacctcatcg 639001 gagacgtcaa attcgccatc tccgccagat cgttttatca ggtcaaccca gagcaaacaa 639061 aagtgctcta cgacaaagcg cttgagtacg ctgagcttca aggggaagaa accgtcatcg 639121 acgcttactg cggcatcgga acgatttctc tcttcctggc aaagcaggcg aaaaaagtgt 639181 acggtgtaga gattgtgccg gaagcaattg aggacgcgaa gcgaaacgcc gaattaaacg 639241 gcaacacaaa cgcagagttt gctgttggag aagcggaaac cgtgattcca aagtggtacg 639301 aagaaggcat tacagctgat acgctggtcg tcgacccgcc aagaaaaggc tgcgacgaag 639361 ccctcctgcg gacaattgtg gagatgaagc cgaagcgggt agtgtatgtg tcctgtaatc 639421 ctggcacgct tgcgagagat ttgcgggtgc ttgaggatgg cgggtacgtg acgcgcgaag 639481 tgcagcctgt ggatatgttt ccgcatacga atcatgtgga gtgctgtgtg ttgataaaat 639541 taaaagaata aatagtcaaa aatctatgct gatggaactg ttggttctct aaaacgataa 639601 ttgatttcaa tggttccatt tgcatgtact tctatttcat ctactaacaa atgaagcatt 639661 tcgggggtaa gtgtaccttc cttcatgaat ttatctaagc tctttttaaa atcaattatt 639721 tctttttcaa tcttttgaaa ttctaggtcc ttagatagtt ggtgaagggt agtttcaaaa 639781 tttgaaatat cttcattggt gatatttatg gctaattggt aatcttcttt agatataaca 639841 ccattagcaa gagagataac taaattggat ttatctctct ttttatcgtt taatttttca 639901 ttaatttcga ttatcttaga ttcgattttt tctttgtact ttaacgcttt ttcacttaat 639961 tctttaaaat aattttcctt actgaatttc aaatatatct tatttaggtt ggttattact 640021 ttatcagtta aatctatttc acttacgtaa tgatcactac atgcttttaa accatgttta 640081 ttataacttc cacaaacata accttttcga ttctttttaa aatgcattga cctcctgcaa 640141 tctttgcaaa ccgcagtatt tgtaaagaga tgtacttcag cttgaggtct ccttcttttt 640201 ctagttatta aaatctcttg tacaataaga aagtcttcta aaggtatgat tggttcgtgg 640261 cttttttcaa taattatttg gttttctagg ttaactgacc ttcttctttt actggtaaca 640321 ctcggtctat attctctaca ttgttgtagt gtcccagtat agtgaggatt ttcgagaatt 640381 tttcttattg aagatccgtg ccatttgtca gtagcgttct ttttgcgggc aagctgcgag 640441 ggactagtga ccccttcgtt atacaatccc cttgctattg catcaaagcc ttttccagca 640501 atatattctg aaaagattct aatatttact attttctctg cgtttgctga atttgagaga 640561 gatatgattg tagaacgaac tcaagaaggt aaaatgttgg ccaagcagaa tccggatttc 640621 cgagaaggaa gacccaaaaa gttcacaaag cagcaaatca atcatgcatt aacattacta 640681 gaaaatcatt cgtataaaca agttgaagat atgactggga tatcagtttc tacacttgta 640741 agagctaaaa agaagaaagc tgctgaagct ataaatggat aaatattgtg aattaattat 640801 tcaatatctt gagaaatttt tataaaagta atcaaaagtt taatggggga aacgaaatgg 640861 cgctcattga tttagaagat aaaattgctg aaatagtgaa tcgagaagat cattcagatt 640921 tcttgtatga attactcggt gtatatgatg ttccacgagc tacaattacg cgcttgaaaa 640981 aaggaaatca aaaccttaca aaacgggttg gtgaagtaca cttaaagaat aaggtgtggt 641041 ttaaggaggc taagaaagga aagctctttg acgcccttat tgatatagaa caacaagttg 641101 aatatctttc agctaagcca cgatatttat tagttactga ctatgatgga gtattagcga 641161 aagatacaaa aacattagag gctcttgatg ttaaatttga agaacttcct cagtatttcg 641221 atttcttcct tgcttggaaa ggtattgaga aagtagagtt tgaaaaggaa aaccccgctg 641281 atattaaagc agccgaacgt tttgcacgga tatatgatgt acttcgtaaa gaaaacaata 641341 ttattgagac taatagaggg ttagatttat ttcttattcg tttactgttt tgttttttcg 641401 cagaagatac tgacatcttc aaacgaaata gttttacgaa tttaattaag actttgactg 641461 aagaagatgg ttcaaatcta aataaattat ttgctgattt atttatcgtg ttagataaaa 641521 atgaacgaga cgatgttcca tcttatttaa aagagtttcc gtatgtaaat ggccagttgt 641581 ttactgaacc acatacagag ttggaatttt ctgccaaatc cagaaagtta attattgagt 641641 gcggtgaatt attaaactgg gctaaaatca atcctgatat ctttggttca atgattcaag 641701 ctgttgcttc tgaagaaagc cgtagttatt taggtatgca ctacacaagt gtccccaata 641761 taatgaaggt tattaaaccg cttttcctag ataaacttaa tcagtctttt ttagatgcat 641821 acgatgatta tacaaaactt gaaaatcttc taacacgaat cggcaaaatt aaattctttg 641881 atcctgcatg tggttcaggg aactttttga ttattaccta caaagaatta cggcgtatgg 641941 aaatcaatat tataaaacga cttcaagaac tcttgggaga gtatctttat gtaccttcag 642001 taactttatc tcaattttac ggaatagaga ttgaagattt tgcacatgac gttgcaaaat 642061 tatcactttg gattgctgaa catcaaatga atgaagaatt aaaaaatgaa gttcataatg 642121 cagtacgccc aacgttacca cttcatacag caggggatat tcgttgtgca aatgctatta 642181 gggttgagtg gactgaggtt tgtcccgcac aaggatctga agaagtatat gtttttggta 642241 atccaccgta tcttggttca aaaaaacaaa acaaagaaca taaatctgat atgttatcaa 642301 tttttggaaa agtcaagaat ggtaaaatgc ttgattatat ttctgcttgg ttttactttg 642361 gtgctaaata cgcttcaact acaaatgcaa aagttgcctt tgtatcaaca aattcagtta 642421 ctcaagggga acaggtttct atcttatgga atgagttatt caagtttgga attcaaatca 642481 attttgccta taaatctttt aaatgggcga ataatgctaa aaataatgct gcggtaattg 642541 ttgtgattgt aggttttggc ccgttagata ccaaagtaaa caagtattta tttgttgatg 642601 aaacgaaaaa gctagtttct aacattagtc cctatttaac tgatggtgaa aatattcttg 642661 tttcttctag gacgaagcca atttcagact tacccaaact gcattttggg aacatgccta 642721 atgatggcgg aggattactc tttaccatta cggaatatac agacgcaatc aataagtatc 642781 ctgaattagt tccctatttt aaaaagttta taggttcagt agagtttatt aatggtggtt 642841 tacggtattg tttatggctt aatgaagcaa aatatgaaaa aataaagtct aatcctctaa 642901 tacaagaaag aatctcaatt tcaaaaaatc acagggaaaa atcaacagat aaaggaacga 642961 ataaacttgc attaactccg tggaagttta gagatactca tgaaacaact aattattcca 643021 ttgttgttcc atctgtgtct tctgaaaata gattttatat tccaatggga ttagcaggtg 643081 cagatacaat tttgtcaaat ctaatttatg taatttacga tgcagaaatt taccttctag 643141 gcattttgat gtcacggatg catatgactt gggtaaaagc tgtagccgga agattaaaaa 643201 ctgactatag gtactctgca ggtttatgtt ataacacttt ccctattcct gaattatcaa 643261 caagaaggaa gaatgaaatt gaagaagcaa ttcttgaaat tcttgatctt cgtgaagagc 643321 agggtggtac attagcagag ctttataacc cttcaacaat gccaattgaa ttaaaagtag 643381 cacatgaaaa gttggatgga attgtagaaa gagcgtatcg tcaaaaacaa tttgaatctg 643441 atgaagaacg cttagaagta ttgcttaaat tgtatcaaga aatgacagaa cggtaggtgt 643501 aaggtgtatg gaaaatataa ttgaaattaa ttataaccaa actggtaaaa gtaagaaaac 643561 aaatgaatac ggtatgcgtg aaatgcaggc aagagctttt gaaaaacgta actcacaata 643621 tctcttagtt aaagcaccgc cagcttctgg gaaatctaga gctttaatgt ttatcggttt 643681 ggataagctc ataaatcaag gtttgaggaa agtgattgtt gctgtacctg aacgctctat 643741 aggttcttca tttaaaaata cggatttaaa aagttatggt ttctttgaaa attggaaagt 643801 tgatcctaga aataatttaa ctgttggcgg agataactct aaggttaaat cttttgttcg 643861 ttttatggaa tcggacgatc aggtgttaat atgtacgcac tctactttgc gatttgcgtt 643921 tgaaaaaatt gatgataaag catttgataa ttgtttactt gcaatagatg aatttcacca 643981 tgtatcggca gatgtcaatt ctcgattagg tgaattgtta agaagtatta ttcataattc 644041 atcagcacat attgtagcga tgactgggtc gtatttccgt ggagattctg taccaatttt 644101 attaccagaa gatgaggaat tatttgacaa ggtaacttat tcctattatg aacaacttga 644161 tggatatgaa tatctaaagg gatttggtat aggatatcac ttctatcaag gccagtacac 644221 atcagctatt aatgaagtat tggatacaaa taagaaaaca atcgttcata ttccaaatgt 644281 aaactcaggg gaatcgacaa aggataagta cgatgaagtt ggtaagatac ttgatatgat 644341 tggtgaagtt gaatatcaag atgatgatac tggaattatt tatgttaagc gacattctga 644401 cggtaaaaca ttgaaaattg cagatttagt agatgaccaa gttggaagag aaaatgtcgt 644461 tgcgtatttg cgtaatattg aagccctaga cgatttagat ataattattg ctcttggtat 644521 ggcgaaagag ggctttgact ggccgttttg tgaacatact ttgacagttg gttatcgtgg 644581 ctcacttaca gaaatagtac aaataattgg gcgctgtaca cgtgatagtt acaataaaac 644641 ctatgctcaa tttaccaacc taatcgcaat gcctgatgca aaggatgaag tagtgactta 644701 tacagtgaat acaatgctta aagctatttc tgcctcactt ttgatggagc aggtccttac 644761 acctgacttt aaatttaaac gtagaagaaa tgaaagtgaa aaatcttcta ctacaggaga 644821 attattcgtt aagggattga aagaaccatc aacagaaaat gtcaaaaaga ttattgaaaa 644881 tgatattaat gatttaaaag caaaaatcat gcaagattca caagtccaaa aaacatttag 644941 tggagaagta gatcccaaag tattgaacaa agtgttgatt ccgaaagtta ttcaaaaagt 645001 atatccaaat ttatcagatg aggaaattga ggaagttaga cagcacgttg ttctagatac 645061 agttatgaaa ggtgctaagt ctgaagttgt aggaagtaaa gaatttataa gaatggcaga 645121 taagtttata aacattgagg atttagatat caatctgatt gattccatca atccgttcca 645181 aaaagcattt gaggttctat cgaaagaatt gaactcacca gtgctaaaac tgattcagga 645241 aactattgat gcaaaacgta ttaattttga tgaagatgaa ctagtattca tatggccaaa 645301 ggtttaggaa ttttatcgtt caactggtag aagacctgat tcaaaatctg aagacccact 645361 tgaaaggcgt atgggtgaag ctgtattata catgcaagag cttaggagga aacgtgaaaa 645421 tggcaagtaa tagataccat tctattaatg aaatcatgga aagtcagctg ttttaccaaa 645481 tcacaacacc acctaagaaa acacaaaaag cccagtatga tcctgaagtt gaaaagtttt 645541 tggagattat tgaattcgtc aaagaaaatg ggcgagaacc ccaaaaagtc cctactgatt 645601 taactgaaag aagtttagca agtcgattaa ttgggattcg gaaagatcct gatcgtatgg 645661 aatatttgaa agagtatgat gaaattggat tacttgaagt aagatcgaag gaactaacaa 645721 ttcctaaaat ttcttcaatt gatgatattc taaaaagtgg cttatctgca ttattaggtg 645781 ataatttaaa taatgatata actaggtcaa tttttgatac aagttcactt caaaaggtta 645841 cgacaatgcc tgaatacgtt gcaaagcgta aaaaaataaa agattttgga aagtttgaag 645901 agctattcaa gaagtgccac aaggaaatta cagagggtaa acgaaaaatt ttaactttca 645961 aaaatgaaca agacatacag tcaaatagtt tttatatatt aaaaggagtt cttctttatg 646021 ttgaagatgt gggagaacgt aaaaaagcaa agggaaaaac caatgctaga cttcgatgta 646081 tatttgaaaa tggaacggaa tcagatatgt tactacgttc cttatcagcg gagttatata 646141 aacatggtag acgtgtgacc gacaatgaag atacattgtt ggataatgtt agagaagatg 646201 atgtttcgac tggctttatt tacgtactaa aatctttgag tacagatccg caaattagtt 646261 ccattaagaa tttatataag atcggtttta caactggttc agtagaaaat agaatcagga 646321 atgcagaaaa tcaatcaact tatctttatg ctccagtaga aattgtaacc acatatcaag 646381 tgttcaatat gaatgctagc aaatttgaga cggcaatcca tcatgcgcta gcaaataata 646441 atttggatgt ttctattttg ggggcaaatg gaaagatgtt agttcctaaa gagtggttcg 646501 ttgtcacact tgaagattta caagctgtaa tagatgagat tgtgatgatg gttcatcttt 646561 atgactaaat tagtatatta ggattttagt attaataata attttatagt agactatgaa 646621 aaaatttgat gccataacaa taacttgttc cgctttggag tttgtcacaa ttgtagaatt 646681 atgtgttgcg agtattaata ggaaggggtt gagcgaccgc aaaaaaaatt ttcggtgctg 646741 tccgcaaaag ggagtttggg tgttttgcgt tatatttggt tgtgtgaagg ttagcggaaa 646801 ctcaattcgt gaagttagga ttgcggttat tacgactgag tagtttcgtc atactctttt 646861 agcagttttt ctgtcttatg catttctttg agcatcggat tcatgtagtc gttagctgat 646921 tctagatatg ctctcgtcag agtgtctagt ttatttctaa ctttagagag gtcttcttcg 646981 aattttccat ccgatgattg aaggataaat tcttttgcct cttcatatct ttttaatatg 647041 tttttcacca ttggagttgg attcttttga tttattgttt ttattacagt gattgttaaa 647101 tttatttgtt ttattaattc ttttcttact gtcaaggtga tgctcctttt aaatctctat 647161 tctatttgag agttgctata tctgtttaat ggtttgatag actactcatc tttataattt 647221 agagcaattt ttacaacttg ttccgctgtg taatcttcat tgctccagaa aattaaatca 647281 cttggtgccg gataaggaac atttttctct aataaatcga gatattcact gactttctca 647341 tcatctaatg ttgggttcat taattccttt acaagaaaga tcaactcttc ttttgtcagt 647401 ttatccattg tttgccctcc aatagattgt atctccattg attttacaaa tgactttatt 647461 tcttctgata atgttatagg ttgtttgcat aatgatagat aattgtcttg agaaaagtta 647521 gtctcattat agagtttatt aattgtattt ataacaatat attcatatgg aaaacctcta 647581 aaatatcttt attttagatt ggtttataaa aaatagctca gcagagtagg gctgagccat 647641 tttttaatta tagaccgagg taactaatta caaattcttt atcatcctca tcttcaggca 647701 aaataccaag gtttttatat tcccatattg cgattctttc atatccatct aattctgagg 647761 ctaaaatatc atcataatta taatctaatt ggaattctcc gctacgatcc aatgttagtg 647821 taaggttagt ccaaacatca tcgttattat ttctgtgttc agttcttaat tcttcaaaaa 647881 gttctcttag ttctcttaac aacgtcttga aaatatcctt gcttacgttg taatggctag 647941 gtatatcttg tgaataaata atttgattat tttctggtgt tctgaaatga aaaagaacca 648001 ttgtggaatc atctaatact tctgcataaa gatatatctt tgtccattca ccaggtatga 648061 tgtcattgag tttttctcca ataagttgat acaaatcttg catcttccta gtttccattc 648121 ttctaacccc caggctgatt tttaatagag acgcttattt cttttctgct cccaattttg 648181 taggttacat cgaaatatga tggtctaagt gaatccccag aatagactgg ttctatttga 648241 actgctactt ttttaggtgg ttttttgctt agggcttttg cccactcctg ctccatctca 648301 taccatttcc caccgctcct attaatctga gaattcatcg gcacgatatt gtcaaactgg 648361 cctgagcctt tgaattgggt ggcgattaaa tggccgccgt catcgtcagg ctttcggtcc 648421 tggggctttc cagcattcgt ttgtgcatat tggtttcgtt tcgcttctcc cagctgcaag 648481 tctgctttga cacttgtaat tctaccatag ttgtcagtcg tgtacgtgta gccttctttt 648541 gttttgtaga tgatattagg cttcagcact ttctttctgc tccatcttgc gaaatgctcg 648601 ccgtatttga cggttaccgg cggtacatgt ggcgctggag ttcgtcttcc gcttgatgac 648661 gttccgtatg gtttcggcag gatgaccttg gcgaattttt gcagtccttc tttaagcgtg 648721 accccgttga ctgcgttgta aggaacgcct gccggcacta aatcatgacg gggatgatac 648781 gggagaatat ccgcaagtgt gagatctccg atttgattta acttggtttt gacgtgtttt 648841 tttgatactt caatgcctgt gtttactttt tgtttgatgt gatcaacggt ttgttttgag 648901 actgttatgg ctttttgggc tgttgctgat ttgcttgctg ctgttttgac tttggtcgtc 648961 actttggcgg ctgtgccagt ttttgagacg gctcctacgc cttttgtgcc gacaattgat 649021 gtgacaacag tgccaaccgc atatgacacc catcttgctc ttgagtaggt gtcaccattc 649081 accatgtctt tttgatacga ttcttcgatt gccgctgaaa tggcttcata cgttttgatc 649141 gggtgagcca tcgctccggt aatcgcttca acggttcctc ccggatctgt gaccatatcc 649201 cacaggccta cgaccgcgtc tttcccggaa tcataaaggc cgacggcaac ccctttgaag 649261 cctgcttcaa gctcacgcgt gttttcaatt tgggtgaagt atctctgttg ttcagctgtc 649321 agattttcat agccgatcgt ttttgccatt tcgtagaatt catcggcatc tgcataatcg 649381 tagtttttca gtctttcttt cagtttctca atctcgcgtt ccttcgcttc ctctttctta 649441 atcttcaagt aagcctcagt ccgcttttca atgtcgcctt ttttcttatg tatgtcactc 649501 tcacggtacg ccttggcgtt gtagtggatg ggtgtggcgt ttttgccttt acccgttgct 649561 tcttggagct tttggaagtc ggatttgatg aattgttcgt ttggttcaga cagggcgtat 649621 tctgttttca ggtcttcgtc caaggcgtcc aatttttcca gtgttttttt gcgtttgtcg 649681 ttggcatcgg ccagctcgtc tttgaaggtt tctgttgaaa acaggtcgag cgggaggatg 649741 tcgtcgatat cgtttaggat gtctttcatc gcttttttct gttcggacat gatggattta 649801 gattttttat tggcatttgc cagttcgtgc tccaggaagg attcttcgat gtatgcgtct 649861 gagaggcctt tgtcttcggc ggctccggcg atgctgttga aaaatgcgat tttcatgtcg 649921 atgtagtcga tccactggtc ggcgacgccg acgtggtcgt gatagaatgc cttgatgttg 649981 ctggcgcctt ttcctgagaa ttcactgtca ctgagatcag cgactccttt taacgctttt 650041 ctcaagttga ccatttgcgt tcttagttct ttgtactctt ttgcacggtc tgtcgcttcc 650101 gaaagcagtg ttttcgcttc aaatactttc atgaccattt cccttctttt gttcgctcaa 650161 tatcaaaatt ttaccacggg tcgggataag gtgggggtga gaacgtgttt tggtggaaaa 650221 atgagtcatt tggcatgtgt ctttattcgt ggagggattg gaggaaacat ggtcgaaatg 650281 atattgattg ctacacattt tttggaagtt tgtattctat attgtttttt aaggagcatg 650341 ttgatgacga aaaaacggat tacatttggt ttattagttt taatggtatg tgtcatcctg 650401 tttgttctgt atgttcagtt acgcaataaa gatagtattc ctgtccaatc ttccgccatt 650461 caccccgaag aagaccgcat cttttttatt tactccaatc ctttcataaa agaaagcgtg 650521 ctgctttcaa cctctacagg cgaacggttt aacaggcgta cgtttaaggt ggcggatgtg 650581 ccttatattc aaacgaaatc ttatgcatca acagaccttg tattattggc ggaacacgag 650641 cctttttact acacgctgga gaaggatgtg atcaaagagc atccgctgtc agatccattt 650701 gcgttttggt atgaggggaa ggatgtcact attgaggcct ataatgttga tacgacggga 650761 aatgagatcc acataaacga cagaaaaacg aaaaaggaat atacccttac cttgcctccg 650821 cttgtcacaa tgggggccag tgatgagaac tttatttata tcattcaaag catgtctatt 650881 tacgtgattg acagaaaaac agaggaaatg attgagaccc tgagcttagc ctcatacgct 650941 gatcaattcg cagactcgga ggaatttatc gtcgcgagct cggatcataa attgactgtg 651001 attgaaaaag ggacatggaa gacgacatat attgcgtatc ctgaagatct tgaatatgca 651061 gatactgtgt actatgacaa agaaagcggc agtttttacg tggcgtacga ggacaaagag 651121 ggtggagcga acttgctgga atatggggag gatttttcta ttcacacata cagcttgaaa 651181 ttcccttata tggaggcgaa gtttaagggg aatctattgt atatagttgc ccaggaagag 651241 cataaaaagg gcatcggcgg atacgtgggt gtgtttgata tccattctaa ggagatgctt 651301 tatcagtttg atttgcctga ggaacaggtg aaggttcagg attttgttgt ggttgacaat 651361 aagtgaatac tatatgaaat agaatgacaa agacccttgc ataaagggtt cttttttatg 651421 aaaaaaacaa attgacagga tgaaaaaaca atttcttcct tctatattgt tttcaaaatt 651481 tgggattgat agaatatgac atatctcata gagaaggagg gaagccgttg agtcaagcca 651541 taccgtcttc gcgtgttggt gttaagatta atgaatggta taaaatgatt cgccagttca 651601 gtgttccgga tgctgagatt ctgaaagcgg aggttgagca ggacattcag cagatggaag 651661 aagatcagga tttactgatc tattattctc tgatgtgttt tcggcaccag ctgatgcttg 651721 attatttgga gccgggaaaa acatacggga atcgccctac agtgacagag cttcttgaaa 651781 cgatcgagac ccctcagaaa aaactcacag gtcttttgaa atactactct ttgtttttcc 651841 gcggcatgta tgaatttgac caaaaagaat atgtggaagc gatcggatat tatcgcgagg 651901 cggagaaaga actgccgttt gtgtcagatg atattgagaa agcggaattc cattttaaag 651961 tggcagaagc gtattatcac atgaagcaaa cccatgtgtc gatgtatcat attcttcaag 652021 ccttggacat ttatcaaaac catcctctat acagcattag aacgatacaa agcttgtttg 652081 tgatcgccgg caactatgat gatttcaaac attatgataa agcgctcccg catttagagg 652141 cggcgctgga attggcaatg gacattcaaa atgacaggtt tatcgccatt tctctattga 652201 acattgcaaa cagctatgac agatcaggag acgatcagat ggctgtagaa catttccaaa 652261 aagcggcgaa agtaagcaga gagaaagtgc ctgatctgct tccgaaagtc ttgtttggat 652321 taagctggac attatgtaaa gcgggccaaa cacagaaggc gtttcagttc atagaggaag 652381 gattagacca tatcacagca cgttctcaca aattttataa agaattgttt ctgttcttgc 652441 aggccgtgta caaggagact gttgatgaac gaaaaattca tgatctttta agctatttcg 652501 aaaaaaagaa cctgcacgct tacattgaag catgtgcccg gagtgctgcc gctgtttttg 652561 aaagcagctg tcactttgaa caagcagctg cgttttatcg gaaagtgctg aaagcccaag 652621 aagatattct aaaaggagag tgtttatatg cctattaaga aaaaagtgat gatgtgtctg 652681 gctgttactc tagttttcgg aagcatgtcg tttccaaccc tgacaaactc cggtggattt 652741 aaggaatcga cagatcgaaa tacgacgtat atcgatcatt ccccttacaa acttagtgat 652801 cagaagaaag cccttagcta gggctttttc ttgctttacg gaagacgttc cattttccac 652861 atcgcggcat tccttctatt tctaacgcaa gacactcgaa acaaccaaac catttgaggt 652921 ataatggata aagtgaataa cagtatttag attgatatat atgaaagaga gtggaacatc 652981 atgggccgta agtggaacaa tattaaagag aagaaggcgt ctaaggacgc aaatacgagt 653041 cggatttatg cgaagtttgg ccgtgagatt tatgtggcgg cgaaacaggg cgagcctgat 653101 ccggaatcca accaggcgct gaaggttgtg cttgaacgtg cgaagactta cagcgtgccg 653161 aaaaacatca ttgaacgtgc gatcgagaag gcgaagggcg gagcggaaga gaattacgat 653221 gagcttcgtt atgagggctt cgggccgaac ggatcaatga ttatcgttga tgcgctgacg 653281 aataatgtaa accgtacggc gccggaagtg cgtgcggcgt tcgggaaaaa cggcggaaac 653341 atgggtgtga gcggatctgt tgcttacatg tttgacgcga cggctgtaat cggtgtggaa 653401 ggcaaaacgg ctgacgaagc gcttgaaatc ctgatggaag cggatgttga tgtacgtgac 653461 attttagaag aggatgacag cgcgatcgtg tatgccgagc ctgatcaatt ccatgcggtg 653521 caagaggcgt ttaaaaacgc gggtgtcgag gaatttacag tagcggagct gacaatgctt 653581 gcgcaaagtg aagtaacgct tccggatgat gcaaaggaac agtttgaaaa attgattgat 653641 gcattagaag atttggaaga tgttcagcag gtatatcata acgttgattt aggtgagtaa 653701 ggagtgagca ggctgttatg gcctgctttt tttgtcccgg aaattgtttt agctgtatgt 653761 aggcggccgc ctatacgatc tataagatat tctcatactc tggactgtaa cctatgtgaa 653821 ggagagagta aatatgactg atacaagaca tatgtatggc ggacctggtt ttggtcatta 653881 tcagggcttt ggtattggcc acccgggcta tggcatgcaa agcacaggct atccgggcta 653941 tggcatgtat ggaggccacc cgggctatgg catgcaaggc tacccagatc acggcataca 654001 tggaggagtc ggcggctatc cgggatatgg tgggtacggc ggttacccaa gcggcggcta 654061 tggaggctct ccgggaactg gaagctatcc gagcatgcac catgaaaatg atggccatca 654121 ccactattat caccatcatc atgatggaaa agataatctt catcaccatc atcaccatgt 654181 tggaaaggat aatcatcacc accatcatga tggtcattat ggccaccatc atcaccatat 654241 gggccactgg ggaaaagacg gttataaata aagaagatga tgataaaaag aggacactct 654301 tgcagatcaa gagtgttttt ttagcttttt tcttgactgt tcagtctgga aaatggtaac 654361 atttgtttca ggaggtgatc attttttggg gaggaataaa gaatttgata cggcgcttgt 654421 tcttcacagg gcgatagagg tttttggaga gtatggctac gaaggaacgt ctcttcagga 654481 tctgctctct catttaggca ttgcgcgcca aagtttgtat gatacgtatg gaacgaagcg 654541 tgatttgttt ttgtccgctg tgaaatcgta tcttgaaggg aaaaacgctg ccgttatgga 654601 aaggcttgaa gcgccaggat ctgtaaagga agccattcgt gatatttttc aggagggtgt 654661 caatgccctg agggatccgg aacgggcgaa ggcgtgctac attattaaca gcgcgattga 654721 acagatcccg catgaccctg agcttgcccg gtattttgaa agacaatcca agcagcttga 654781 ggacgctttt tatcacgggc ttttaagagc gaaggatcaa ggagaattga atggcgaaga 654841 tactgatata tctgcgcttg ctcggtacct gaatcagagc aggctgtcac tgacatttat 654901 tgcaaaagtg acggcagata tggatcggct tcaggaccat gttgacgtga gtttatcagt 654961 gcttgattaa catgtggtaa aggattcttt gcccatgtat gtactttttg gactgaatag 655021 tctagaaata aaaatgaggt gatgatgaat gttgatgaat gagtttgaaa aagcatgtga 655081 aacattgaga aagtttatgg cttatatgct tgagaaggac atgaagagct ggacggagct 655141 ttgggatgag aatgctgtat ttgagtttcc ttatgcgccg gagggatcac caaaaagaat 655201 agaaggaaaa gcggccattt acgattatat taaagattat cctaagcaga ttcatctttc 655261 ttcatttacc gctccgacag tgtaccgttc agcagactcg aatacggtga ttgcggagtt 655321 tcaatgtgac ggccatgtga ttgagactgg actgccttat cgccaaagct atatcagtgt 655381 catcgaaacg agagacggcc gcattgtgcg ttatagggat tattggaatc cgcttgttgt 655441 aaaagaggcc tttggaggat catttttgca aacagaggag agtgggaaat gatgaaacag 655501 aatccgattt taatcacggg cgggaccggc acagtcggca gccgaatcgc cagccgttta 655561 ataaagctgg gatacagagt gcgtattgca agccggaaaa agggcgcgct tgctgatgct 655621 gagtatgtgt attttaattg gaagtacgcc tccagtttta cgcctgctct ggaacaggta 655681 aaacagatct atcttgttgc tccggtcggt gtatttgatc cggctcccta tgtgcttccc 655741 tttttaaagg aagcaaagcg tctcggcgca aagcgggtag tgatgcaaag tgcgtctgtt 655801 gtctccgaga acggtcccgt gtttggcgcg cttcaccagg cagtgcgcga gtttccagaa 655861 tggacggtgc tgcggccctc atactttatg caaaatttca tcaatgtcca gcaccgcatg 655921 tctattcaaa cggaggggcg catcacaacg gcttcgggtg aaggaaaact tgggtttatt 655981 gacgctgatg acatcgcaga aacagccgtc agggctttga ttgatgatgt tcctcatcaa 656041 acacatcata ttctgacagg tcccgaggcg ctgagctatg ccgaagcggc ggagatcatt 656101 ggagctgcgg cgggacgccg ggtggagcat gtcagcattt ctcgttccga gctgcagcat 656161 aaaatggagg caggaggttt gcccgcggat tatgcccatt ttatggcgaa gcttgatgag 656221 gcaattagcc atggtgcgga acatcgggta acggatacag tgaagcgtgt gacgggaaaa 656281 gaacctcgtt cgctgtcaga gtttgcggct gctcatgctg catattggac ctcattttgg 656341 actgaatagt ctagaaagac cttcggcgct tccgaaggtc ttcttattga aaaagctaag 656401 tcgtgtttta gtcataatca tgcctcctgc ctcataccta ttaaggtcat tgtttttgag 656461 aaaggaggag ccggaatgaa ggatatgcag ccgtttacgc ctgtcaaatc atatacgccc 656521 tttcacagcc gttttgatcc ctgtccgccc atagggaaga aatattacag aacgccccct 656581 aacctttata tgacctttca gcctgagcac atggagcagt tttcgccgat ggaggctttg 656641 aggaaaggca ccctttggaa ggatctctat gatttttatg aaaaccctta tcgaggggga 656701 gacgcacatg gcaaaaaagg ttgacgccga atattatcgt cagctagagc aaatacaggc 656761 tgctgatttt gtgcttgttg agctgagtct ttatttaaat acacatcctc atgatgaaga 656821 tgcgttgaag caattcaatc aatattccgg ctattcaagg cacttaaaaa gacagttcga 656881 atcctcttac ggaccgcttc tgcagttcgg caacagcccc gcgggcaagg attgggattg 656941 gggaaaaggg ccatggccgt ggcaagtata aggaggaatg cctgaatgtg ggtgtatgaa 657001 aagaagctgc aataccctgt caaggtcagt acgtgcaacc cgacgctggc gaagtatttg 657061 attgagcagt atggcggagc ggacggcgag ctggccgcgg ctctccggta tttgaaccag 657121 cgttatacga ttcctgataa ggtcatcggc cttttaacag atatcggcac ggaggagttt 657181 gcccatttgg aaatgattgc gaccatggtc tataagttaa cgaaagacgc cacaccggag 657241 cagctgcgtg aagctgggct tggcgatcat tacgtcaatc acgacagcgc gcttttttat 657301 cataatgcgg cgggcgtgcc gtttaccgcg agctatatcc aagcgaaggg cgatccgatt 657361 gccgatttat acgaagatat tgccgcagaa gaaaaggcgc gggcgacgta tcaatggctg 657421 attgatattt cggatgatcc tgatttaaac gattccctgc gttttttgcg tgagcgtgaa 657481 atcgtacact ctatgcgctt cagagaagcg gttgaaattt taaaagaaga acgggataaa 657541 aagaagattt tctaataggc agattggcct ctctttcata caccctttta catacagaga 657601 aaatggtctg tttttgcagt ttggtctgca ttataatcaa ggtgtgtgtg caagcttact 657661 ttttgattgg gaggccttta tgacagcttt taagattgag aacgaaacga ttgcagatgg 657721 attttacgcg tgtccggccg tctatgagga tgcagaatcg attaccgggt tgctcgtccg 657781 aacagctgaa tggctccggg atcggggttc taaccaatgg agcggacttc tcaaagggca 657841 agatatacat gatatcacgg ggtcaattga aaagggacat gtgtttgtgt ttaaaaaaga 657901 tgaagagctt gcggctgtcg tgatgctgct gcctgcaccg agcgagtggg accggacgct 657961 ttggggagac gatgggcatg aggagtccat ttatttacac cgcctcgcag taagccgccg 658021 gtttgcggga caggggcttg gagcccgcgt ccttcagtgg gcggagacgg gcatacactt 658081 tccggaaaaa acgcggatcc ggcttgactg tgtcgctgat agtgacgccc tgcattcctt 658141 ttatcggcgt atgggatatg aattcatggg tgctgatgcg tccggatatc atttgtttga 658201 gaaagagatt acggcagaat aagcgtcctt tgcagggggc ttttttgtct ttttctaaaa 658261 gggaggcagg cgatgtgtgg tcaatattat ttgtgacagg gattgtgacg gcttgtctgt 658321 ttgctggcgt atccgtattg atgcggatga gatttcctga caaaagtcgg ccggaatgga 658381 tgttggccgg gctgatcgtc cttggtgtgt ttgcgatctg gtacagcctc gtgtatgtac 658441 gcggctggga aggggctgcg ctcggaatgc ttggattcaa tgtcattttc ggagccattg 658501 ccggatattt gatcgataag gccatccggc gttacaggaa aagataaggc tgctgccgtc 658561 tctcaacagg tcgaaatttt cacagaccgg caggaatttt ctttcgaaag gagaaataca 658621 tattacttta aaatgaaagc gttttccaaa gcaggaaggt gatgttgatg atacacagtg 658681 tggcaaatgg gctgaatcat ttttgtacgt gggtgatgag actggcctat ttgaatgtgc 658741 tttggatttt gttttctctt gcaggcctgg ttgtatttgg gctgatgccc gctactgccg 658801 cgatgtttac agtggcgaga gaatgggcga aggggaatac agatgccccg gtgttttctg 658861 tcttttttcg gacgtttaaa aaggaatggc gggcatcaca gatcctcggg cttatcgttg 658921 tgacggctgc cctgtttctg tttgcggata tgcggatagc ggctcagatg gaccagcctg 658981 tgctcgtcaa tgtattcgtg agcattagtt tgattttcgc gtttgttgtg ctgtatgtgt 659041 tcccggtatt ttctcatttt gacgtaaaaa tcagagaggt gctgagcatc agctttttca 659101 ttgccttcag tcgtccggcg gtgacgcttt tgatggcagc gggcgctgtc ggtgtgcttt 659161 gtctcgttct gtttcatgtc acgtttctat tgtttttcag cgggagttta ctcagcctga 659221 tcttaacgaa gctgtccttt aaagcgtttc ggtcaatgga tcagcggcag gagaaagaaa 659281 aggcggcatg aagaaaagag ttgctggctg gtacaggcgg atgaagatta aggataagct 659341 gtttgtgttt ctatcgttga ttatggccgt atcctttctg tttgtataca gcggggtcca 659401 gtatgccttt catgtgtatg atgagcagat ttaccgcaag tcctcggagg tgcttcggat 659461 gtcttctgaa aggatcgaag acgagctgaa gaagatagag gatgtgtcat atgaaatcat 659521 tacagacgaa cagattcagc gcatcctgag catgcaaaat cgggatgata cgtatgatca 659581 atatcaaatg aagcaggagc tgtgggatca gcttgcggga tatgccagcg atgaaaagta 659641 catcgattcc attcatgtga ttgatgcccg cggctcagag tattcagccg gaagcagttc 659701 ttcagatctt ttgcagcagg agcaggaaga ggtatttaag cgagcgaaag cgaaaagtgg 659761 aagaaatctt tggatgacgc tcggcgggtc agaccccgtc ctgatttcag cacggcagat 659821 caggtcctat caccagctga gtctgaacgg cttgggcatg gtactgatcc aggtcaatgt 659881 aaaacagatg attcgtgatg tgccgaagga ttggggcgat tcagtcggag acattatgat 659941 tgctgaccaa ggcggtaatt tggtgtatac ggcacatgca tcagcgcatg ttcctgaggc 660001 agcaaaagag acgttgaagc accccggtta tgacttgata aaaaagaatg gcaaacgtta 660061 ctttatttct tatcttcaat catcctacca aaattggagc tactataacg ttatcccctt 660121 tgatcagatg ttcgcaaaaa tttcctttat gaaaacagtg atcggcacat gctttcttct 660181 ctttttctgt gtggttttgc ttttcggaag gaaaatcgcc aacagcatca cggagccgat 660241 tgaacagctt gtgaccgcga tgaaatcggt acagcacagc ggcattgaag caggtgtgtc 660301 gctttctctg ccggaacata cacaggatga ggccggcatg ctgaaccgcc attttactgt 660361 catgatgaaa cggattaatg agctgatgga agaaaatgtg gaaaaacagc tcatcattaa 660421 agaaaccgaa ttgaaagcac tgcaagccca gatcaatccg cattttttat ataacacgct 660481 cgagtccatc aattggctgg ccaaggcgaa tcagcaaaag caaatctcaa aaatggtgga 660541 atcgctcggt tttcttctgc gaaacagcat acatatgaag aaggatatcg tgaccattca 660601 ggaggaggcg gacattgtac gtcactatat gaccattcag cgatttcgat ttgaagagcg 660661 cctgaaattc acgttggata ttgacgatga ggtgaagcat tgcctcattc cgaaactgac 660721 gctccagccg cttgcggaaa atgcgattca atacgcgctt gaacccttta caaggccatg 660781 cgccatccgg attcaggcga aaaaggcgaa gggctgtgtc tgtattacgg tcgaagataa 660841 cggccctggc atggatggac ggattcttga atcaacgggt ggaagaggaa tcggactttg 660901 gaatattcgc gagcgcatca gcctgacatt cggagagcca tacggattgc ggattcatag 660961 tgagcatgaa aaggggacga ggattgtgat cacaataccg tgccgaaatg aggtggtgtg 661021 atgtataaaa tactgctggc tgatgatgag aggattatcc ttgatggaat ggcgggaatc 661081 attgagtggg agtcgcttgg cgcctcattg atcggaaaag cgcagaacgg acatgaagca 661141 tatgaaaaga ttgtacataa gcagccgcat atcgtcatca cagacgtcaa aatgcccggc 661201 atggacgggc ttgagctgat caaaaaggtg tcagccgtca gcccgtcggt gcaatttatc 661261 gtcctgtccg ggtttggaga gtttgagtac gcaaaggaag ccatgaaata tggggtgaag 661321 cattatttgc tgaaaccctg caatgaacag cagattatca gctcgctgga ggaaatcatt 661381 gctgagctga agcggcaaga tgtgcacaaa aagaaaacag cccatctgaa acacgagctg 661441 gaccatatcc gttcctttgc agccgatcaa tacttggaag gcttgatcgc cggtgtggcc 661501 cagctttctc cgccgccttc acttgccgga aaaaagatcc gcctcttgat cttaaaaggg 661561 gaacaatcta ttgatgctgc agccagagag gcactcggat cggcactgac agcggtttgc 661621 agcagcggtg aatggaccgt gctcgccgta gaggagaacg ccgctgaaaa ggtggcggag 661681 gtttttgcgg accgcaagat ggccatcagt caggcgggag aactccggca cgcggggcag 661741 ctgtttcgtg acacagctga agcgtctggt gacctgcatg ggagcgcagt gatttcaaaa 661801 atgatcaggc ttattgccga cgagctcgga aatccgaatc tgtccttaaa atgggcggcg 661861 aaggatatgc tgtttatgaa tcctgattat ctcgggaagt tatttaagca ggaaacaggc 661921 gagaaatttt cccaatatgt tacacgggtg cgtcttgagc atgcgatgaa gcagatgaaa 661981 ataaggaggg acgtgagcgt ttcagaaatt gctgaagaaa tcgggtttgg cgataatccg 662041 aagtatttca gtcttgtttt taaaaaatat accggtctga caccgtcaga attcagaaga 662101 aaacagggag gcgcttccgc aggatagcca tctctgtttt tttgactttc gccactgttt 662161 tttgagtgtt tcgccctatc cgaacgcttt aaaataaaat gtaagcactt acattaaagg 662221 ggggattggt ttgaagaaga tttgttacgt gctgttatcc cttgtctgcg tctttttgtt 662281 cagcggatgt tcagcgggtg aagaggcctc gggaaaaaaa gaagatgtta cactcagaat 662341 cgcgtggtgg ggcgggcagc caaggcatga ttatacaact aaggtaattg aactatacga 662401 gaaaaagaat ccgcacgtcc atattgaagc ggaatttgcg aactgggatg actactggaa 662461 aaagcttgcg cccatgtctg ccgccggcca gcttcctgat gtcattcaaa tggataccgc 662521 ttacttagcc caatacggaa agaagaacca gctggaagat ttaacgccgt atacaaagga 662581 tggaacgatt gacgtcagtt caatcgacga gaatatgctg tcgggcggaa aaatcgacaa 662641 taagctttat ggatttacgc taggtgtcaa cgtgctgtct gtgattgcca atgaagattt 662701 gctgaaaaaa gccggtgtgt ctatcaatca ggaaaactgg acgtgggagg attacgagaa 662761 gctggcgtat gatcttcagg aaaaagccgg tgtctacggt tccaacggaa tgcatccgcc 662821 tgatattttc ttcccttatt atttgcgcac aaagggtgag cgcttttata aagaagacgg 662881 cactggcctc gcgtatcaag atgatcagct gtttgtcgat tactttgaac ggcagctgag 662941 gctagtgaaa gcgaaaacgt ccccaacacc tgatgaaagc gcacagatta aagggatgga 663001 agacgatttt atcgtcaaag gcaaatcagc gattacatgg aactactcca atcaatattt 663061 gggctttgcc cggctgacag actcgccgct gtctctctat ctgccgccgg agcaaatgca 663121 ggaaaaggcg ctgacactga agcccagtat gctgttttcc attccgaaaa gctctgagca 663181 taaaaaagag gcagcgaaat ttattaattt cttcgtgaat aatgaggaag cgaaccagct 663241 gattaaaggc gagcgaggcg ttccagtctc cgacaaggtg gcggatgcga ttaaaccgaa 663301 gctgaatgag gaagaaacca acatcgtgga gtatgtagaa accgcgtcaa aaaacatcag 663361 caaagccgat ccgccagagc ctgtgggaag cgcggaggtc atcaagctgc tgaaagatac 663421 gtcagatcag attctgtatc agaaggtatc gccggaaaaa gccgccaaaa cgttccggaa 663481 aaaggccaat gagatattag agaggaataa ttgacgggaa atggggctga cgcaatgaaa 663541 aaaagccgga gtataagaaa agacaatctg gcgggatatg cttttatttc tccgtttatc 663601 atcgggttcc tatgctttac ggtgattccg atgggggcgt ccctgtttct gtccttcacg 663661 agctatgact tgtttacggc gccgaaatgg atcgggctcg acaactttaa ggaaatgttt 663721 acgggtgacg aaaagtattg gcagtctctg aaggtgacgt ttacgtatgt gcttgccggg 663781 gttccgctcc gcctcggctt cgcgcttttt atcgctgtca ttttaaacaa tgcagcaaaa 663841 ggaacggcca tttacagaac gctcttttat ctgccttcga tcatcggcgg gagcgtcgcc 663901 gtggcgatta tgtggcgcaa tatttttggc aatgacgggg tcatcaatgc gctgctgttt 663961 tttgtcggga ttgatcaaaa aattctttgg taccagaatc cgacaagtgc gctgtggaca 664021 ttgattctgc tgtccgtctg gcagttcggg tcgtcaatgc tgattttttt ggccgggctg 664081 aaaaacattc cgtcttcgta tttggaagcg gcaagtgtgg atggggcaaa tcgggtgcag 664141 cgtttcttca agatcacgct tccgatcctt acaccgatta ttttctttaa cctagtgatg 664201 cagacgattt ctgcttttat gacatttaca cctgcctata tcatttcgaa gggcgagggc 664261 gggccgcttg acgggacact tctctattcg ctctatttgt tccagcgtgc gtttaactat 664321 tttcaaatgg gctacgcatc ggcgatggcg tgggtcatgc ttgtcattgt cgggctgatt 664381 acgctcatat tgtttaaaac atcgtcatat tgggttcatt acgagtcaaa ggaggaatga 664441 cggatggagc cggtcaacca gcctgtcaga gaagccccgg tttttgagag aaaaaaagcc 664501 gggcgcgtca gtcccaaacg catactgttc catgttttta cggcaacgct ggcggtgttg 664561 ctgctgtacc cggttatttg gctgtttgtc agctcgttta aagaaagcgc cagtattttt 664621 acaacctcac attctctcat tccagaccct tttattctca gtaactatgc tgaagggtgg 664681 aagggcattg cgggacagcc gtttctgacg tttattaaaa actcggcgat tattgtcggg 664741 ctgtcaacaa tcggtgccgt catgtcatcg gctgtcattg cgtacggatt tgcgcgtata 664801 ccgtttaagg gaaaaaaatt ttggtttgcg tgcatgatgg ggacgttaat gctgcctcat 664861 gaagtgttga tgattccgca gtatattatg tttgcgaaat tagactggct gaattccttt 664921 aaaccaattg tcgttccgca atttttcggg catgcgtttt ttatctttct gatgatccag 664981 tttatccgga cgattcccga ggagctggat gaagccgcgc gaatcgacgg atgcggacgc 665041 tttgcctgct tttggcggat cattctcccg ctgattgccc ccgcgcttgc gacgtctgcg 665101 attttctcct tctattggaa gtgggaggag ctgattcagc cgctcttgta tttgaataag 665161 ccggagcttt accctgtttc acttgcgctg aagctttttc tcgatacaga gtcggcttcg 665221 aactggggcg cgatgtttgc catgtcagcc gtctcgttat tgcctgtgat tcttgttttc 665281 tttttgtttc agaaatatat cgttcagggc atcagtacga ccggattaaa ataaaaagga 665341 gtgttgcaga tggcacagct tatctttgat gaagaaaagg tgacgtcggt tattgaccgg 665401 atcgtgaaac ggacatttca gatggatttt gcgtgggatt ggccgggcgg cgttgcgttt 665461 tacggtgtgg cggaggccta tgaagcgacg gaaaacgagg aatatatcaa tctgttaaaa 665521 acgtgggtgg atgaacagct ggaggatggg ctgccgccgc tttcgatcaa cggagtttcc 665581 attgggcata cgcttttgtt cctccacaag gtgacaggtg atgacgtgta tttggaaaca 665641 gcggccgaga tggcggaata tgtgctgcat aaggcgccgc gctttggcga gggtatcctt 665701 cagcatacgg tgaatgcggc agaatacgta ttccctgaac aggcatgggc ggatacgctg 665761 atgatggctg ggctgtttat gctgagaatc gggcgggtca tggagcgtga ggattatttt 665821 gaagacggcc tgcgccagtt tcacggacat gaggatgtgc ttcaggaccc tgtcacgaat 665881 ttgtactacc acgcctggga caacaaagcg caaaatcatc tgtcggggat ttattggggc 665941 agggcgaacg gctgggcggc actcacgatg gcaaaggcgc tcccgcttat tgaggtgaca 666001 catccttcct ttatgatcat cgacggatcg ctcagagacc agctgagcgc gcttgtccgg 666061 cttcaggatg aatcagggct gtggcataca attttggatg atccggattc ttatctggag 666121 gtttcggcat cagcgggtat tgcttctgct ctgatgtcga gcggaaagct gtatacaaaa 666181 tatgtgcaga aatcgcttgc cgccattttg gatgcagtgg aagaggacgg acgggtcagc 666241 agggtatcgg ccgggacagc cgtcatgaaa aatgccgaag gatacaaaca ggtgccttac 666301 aaacgaatac aaggatgggg gcagggactt gcgctgacgt ttcttgctga tgttttgaaa 666361 acgaaaaaac gcttgtatca gtaaagatag cggcgggggg agagggatga aaaaacagcc 666421 tcaacagaag gaacgggttt ctcgctggaa gggaacgtat ttcaaaagaa actttgtctt 666481 cattttgctg attgcctgta ttcccggatt gctgactggc ggcgcaatct actttctttc 666541 gatcgacaag gtggagaaag agctgcagag atcgcatgaa acacaggtgg cgcgtgaggt 666601 cagccgaatg gatgagaagc tgggagtgct tgaactggca ctcacccaga tggcctacga 666661 ttcttcactg atgaacggat tggccgagag ggatttggag aaagacttta cgttctccta 666721 tcaattaacg aaaaagctgt ttcttttgcg ggatcagcag ccgctgatcg agcaggcttc 666781 catctttctg aacagccccc ggccacttgt gctgagccct gaatacagcg ctttgacaga 666841 acaggaggcg cttcgcaagt atcgctcgct gcttgcctca gaccacagca tttattggaa 666901 acggtcggga aaccaagcga tgctgatcca gctcattccg ggcgcggcgg agaaaccgtt 666961 cggcgcgatc atgctggcgg ttgatccgaa agaaatggaa tcaatcctgc aaagcttgtc 667021 cccctatcct gatggcagtg cgttgctttt agatcaaaat cgagaggtgc tgtttcatga 667081 gggggaaaaa gattttgaaa agactttact tcatgagata aaaaaacagc ctgctgagaa 667141 cggccatttt cagatggaat ggaaaggcaa ggtgtattct gtctcctttg gagaaatgaa 667201 ccggatgcat cagcaatgga cctttgtgtc agcggcgcct ctttcagcta ttacagcgcc 667261 gatggtgttt ttatcaaaag tgatcatcgt gatgctggtc atttgcatcg gtttggcggt 667321 gtgcatgaca tggtatgcat caaaaaaaat ctatcgtccc atccagcatt tgcttggctt 667381 gtttaccgga ggagagaaga aaacatggca ggcgtccggg caggatgaat tcaaatggat 667441 tgaaaagaga tggcaggatc tatcccttga aagccggaag ctccaacagc agctcctgcg 667501 gcagacgccc catatgaaaa agagtttttt gcagcatctc ttacagagcg atttttacta 667561 tgacaacgag gaaagcctca gatttcggat ggaggaggct ggctggaaca tcggcggaaa 667621 cgtgtttcat gtgcttgatc tacaggtgac agggctccgc tgtgaaaaaa gcatcttccg 667681 tgaaggtgat gaacagcttg ccgtgtttac actgactaat atcgctgagg aattggcggc 667741 taaacgcgtt tttcagctct ccatacttga tatcggccgg ctttctgtca ccgttcttgt 667801 gatgaaaaca aacagctctg atctgaaggc gtatataacg gagctggcac gccaatttgg 667861 agatgtaacc ggactatgcc tgacctcgac attgagcagc aagacggagc gtgtcacgga 667921 aattccttct ttatttcagg atgtgaaatg cggcaaatcc cgcaggaagt ttgctaaccg 667981 ggatcaggtc attgatttgc aggccgactt ccctcgggat gagcagttcg ctccttatta 668041 cccttttgag ctggaaaaac aaattgttca gaccatccgg ctggaaagaa aacaggaagc 668101 caaggaactg atagatggat gtatgaagga actgtcggaa aaagcggcca tagacaggca 668161 tgtgcattcc gccctgattc agctgttttc ccgcattcag gaggatattt tgcattccgg 668221 gctcaatccc agcgaactgt ttcagcaccg gaatccgttt cttgatattt cagaattgcg 668281 cgaacctaac gaagcggcgg cctggctgat ggatgtagtg gtgacgcctt acctttccaa 668341 gcttgagggc agaaaaaaca gacagcaaaa gcagctggca gaacgtgtga ttgcgatgat 668401 tcacgaacag tatatggcgg acatttcatt ggaaagctgt gccgatgcgc ttggcatgaa 668461 ttcctatacg ttaagcaagg catttaagca agtgaccggc attaatttta tcgattatgt 668521 gacccagatc agaatcgaaa aggcgaaaga actgctggtc aatacgaata aaaaaattca 668581 tgatgtgtct gaagaagtcg gctatcgcca caattatttc aatcggattt ttaaaaaaca 668641 ggtcggcatg ccgccgggtg tcttcaggca aatgtatcag gaaacgccgt gaaaggagag 668701 aacatgtgat gaagaaaccg attcaagtat ttttagcggg ggattccact gtgagtgact 668761 gcccgcctca tgaagcgccg atggcggggt gggggcaggt attcgggcaa ttgttttctg 668821 aaggtgtgct ggtccgcaat catgccaaag gaggagcgag caccaattct tttgtggagg 668881 aaggaaggct tcaagcaatt gccgagcaca tcacacaagg cgattatttg ttgattcaat 668941 tcggccacaa tgaccaaaaa ccgcggggga cgaagccgta ctccacattt cagcagtttc 669001 ttaccttgtt tgcagatacg gcacgcgaaa agggcgcgca tcctgtgttc gtcacatcgg 669061 tgcagcgccg ccgctttgat gaaaacggac ggatcgagca tacgctcggt gagtatcccg 669121 atgcgatgaa agcactggcg aaggagctcg atgtacctgt gattgatctg cttgcgaaaa 669181 caaaggtgct gtatgaagca tacgggccgg aggagtcgaa gcgattgttc gtttggtttc 669241 agccgaatga acatccgaat tacccggacg gcattgagga caatacgcat ttttcggaaa 669301 aaggtgcaat ggaggttgcg aagcttgtgg cagaaggcat tgaagagctc ggacttccgc 669361 ttaaggacca ccttgtgagc cgggagggaa aagaacatgt ataaggaagg cgcttgcttg 669421 taccgcaatc cgctccggtc taaaagcgat gtgaaggatt ggcggatgga gggaggcgga 669481 cagatctcat ttgacgatca cagcttgcac ctgtcacatg tccaggatga agcgcacttt 669541 gtcttttggt gtccggaaac ctttccagac ggcatcattg tgacatggga cttctctccg 669601 atcgagcagc ctggactgtg tatgctgttt tttgccgctg cgggtattcg cggcgaggat 669661 ttgtttgacc caagtctcag gaaaagaaca ggaacatacc ctgagtatca ttcaggagat 669721 atcaatgccc tccacctgtc gtatttccgc agaaaatacg cggaggaaag agcgttccgc 669781 acctgcaatt taagaaaaag ccgcggtttc catctcgccg caatgggggc cgatccgctg 669841 ccttctccag acgacgctga ttctccgtat cgtatgaagc tgatcaaaga caaaggctat 669901 gtgcactttt caatcaatgg tctgcccatt cttgagtgga tggacgacgg cagcacatat 669961 gggcctgtgt taacaaaagg aaaaatcggg ttccggcaga tggcccccat gaaagccgtt 670021 tacagggatt ttgccgtgca tcaagcggtg agaagatgaa gacgactgta acggatgcgc 670081 tttatgcagg ctgcgaagcg gtggtgaaaa tagcatggct caacgggctg tggctgttgt 670141 ttacactttt gggcggcgtt cttttcggat gggcgccgag cacagctgcg atgtgtgccg 670201 ttataaggaa atggctgatg gggcaaaagg atgtcccgat attttcgtta tttctcgata 670261 cctataaaaa agagtttctc aaggttaatg cgatcggatt ggcgttttcg gctcttttgc 670321 tcatattgtc tgccaactat cattattttt ctgccagtac gaattggctg tcctttgccg 670381 taacaagctg cacgctgctt gcagggcttt tgtatatcat cgcgctgatg tatgtgtttc 670441 ccctttatgt gcattaccag ctcccgcttc gcaaatatat tccgcaggca ctgctgtttg 670501 gcgccatgag accgctgaca actggctgta tgctgatcgg gtgcggattt gtcctttatt 670561 tgctgtatac gcttcctggc ctgatcccat tttacggccc gtgtttattt gggcttgtgt 670621 tgatgttttt tgctcttagg ggatttcaaa agacggaggc ccagcaccat caagccgggt 670681 aacaaaaaaa tgacaaataa gcaaaaaagt gcagtgtccg aaataggcag atgcaaaaaa 670741 gtgaaattga agacagctca caaagcgcat aaaatccaat ttaagtaagc gcttacagat 670801 aaatgagaag gagctgtctg atgattagac gaaggaaacg catgtttacc gctgttacgt 670861 tgctggtctt gttggtgatg ggaacctctg tatgtcctgt gaaagctgaa ggggcagcgc 670921 ggcagatgga agcgctgaac cgggggcttg tagcggtcaa gacggacggg ggcatttttg 670981 tcagctggcg gtttcttgga accgaaaacg catctgtttt gttcaatgtg tacagagacg 671041 ggcaaaaact gaatgctgcg cctgtcaaaa caacgaacta tgtggataaa aacggttcgg 671101 cgggctcaac gtatacggtt cgggctgttg taaacggtac cgaacagccg gcttctgaaa 671161 aagcctccgt atgggcgcag ccgtatcatt ccgtcccgct ggataaaccg gctggcggca 671221 cgacgccaaa gggtgaatct tacacgtaca gcgctaatga cgcaagtgtt ggcgatgtgg 671281 atggtgacgg gcaatacgag ctgatcctga aatgggaccc gtccaactca aaagacaatt 671341 cacaggatgg ctatacgggt gacgtgctga ttgacgcgta taaactggac ggcacaaagt 671401 tatggcggat caatctcggc aaaaacatca gagcgggcgc gcactacacc cagtttatgg 671461 tgtatgacct tgatggtgac ggaaaagcag aagtggcaat gaaaacggca gacgggacaa 671521 aagacggcac gggcaaagta attggaaatg ccaatgcaga ttacagaaat gaacaggggc 671581 gtgtgctttc aggccctgaa tatctcactg tgtttcaagg ttcaaccggg aaagagcttg 671641 tcaccgcaaa ttttgaaccg gcgcgcggca atgtgtcgga ttggggagac agctacggca 671701 accgtgttga ccgttttctc gccggcattg cctaccttga tggacagcgg ccgagcctga 671761 tcatgaccag agggtattac gctaaaacca tgctagttgc ctataacttc agggacggaa 671821 agctgtcaaa gctttggacg ctggactcct caaagtcagg aaatgaagcg tttgccggac 671881 aggggaatca caacctgagc atcgcggacg ttgacgggga tggaaaagat gagattattt 671941 tcggctcaat ggctgttgat catgacggga aaggcatgta ctcgaccggc ttaggccatg 672001 gggatgccct ccatacagga gatcttgatc cgggccggcc ggggcttgag gtgtttcaag 672061 ttcatgagga caaaaatgca aaatacggct tatctttccg ggatgctgca actggaaaaa 672121 tcctttgggg cgtttatgcc ggcaaggatg taggccgggg aatggctgct gatattgacc 672181 cgcgttatcc gggacaggag gtgtgggcaa acggttctct ctactcagcg aaaggggtca 672241 aaatcggaag cggggttccg tcctcgacca acttcggcat ctggtgggac ggcgatctgc 672301 tccgggaaca gctggacagc aaccgaattg ataagtggga ttatcaaaac ggcgtatcga 672361 aaaatatgct gactgcatca ggcgcagcgg ctaacaacgg cacaaaagca acaccaacgc 672421 ttcaggctga tctgctcggt gactggcgcg aggaagtggt gtggagaacg gaggacagca 672481 gtgctctgcg catttacacg acgaccattc cgactgagca caggctgtat acgctgatgc 672541 acgatccggt gtaccggctt ggcatcgcct ggcaaaatat cgcctataac cagccgccgc 672601 acacaagctt ctttttagga gacggcatgg cggaacagcc aaaaccaaat atgtatacgc 672661 cttaactgaa agggggaagg aacgggctgc gcgcagcccg ttcccatcaa atgaaaccaa 672721 aaaagaggca aatggaatac ctgaccagag gtttgattgc ggtacagaca gaacagggcg 672781 tgtttgtcag ctggcgtttt ctcggcacgg atcatgagac gacggctttt cacctttatc 672841 gggatggaaa gcggatcacc cgcgatccaa tcgctgaaag cactaatttt ctcgatcaaa 672901 acggaacggc tgactctgtt tatcaagtgg cggctgtcaa taaaggacgg gaagaaaagc 672961 tttccaagaa agctcgtgtt tggcaggaaa atgtcctgga ggttcctctt gccaaaccgg 673021 aaggcggtgt gacgccggac ggaaagccgt acacttacag cgccaatgat gccagtgtcg 673081 gggatataga cggggatgga gaatatgaaa tgatcctgaa gtgggacccg tccaattcaa 673141 aagacaacgc tcatgacggt tataccgggg aggtgctcat agatgcctat aaactggacg 673201 gcaccttttt gtggcgcatc aacctcggca gaaacatcag agcgggtgct cattacacgc 673261 aatttatggt gtatgacctt gacggtgacg gaaaagcaga aatcgccatg aaaacagctg 673321 acggcacaac agacgggaaa ggacatatca tcggtgatga gcaggccgat tttagaaacg 673381 aacagggcag aattttgtcc ggtccggaat atttgaccgt gtttaaagga gaaaccggtg 673441 aggcgctcac gaccgtggaa tatgaaccgc cccgcggcaa gctggaggat tggggagacg 673501 gctatggaaa ccggatggac cgttttctcg ccgggaccgc ttatttggat ggggagcggc 673561 cgagccttgt tatggcgcgc ggctactata cgagaaccgt gctcgtggca tacgatttca 673621 gaaacggaag gctcaaaaaa cgatgggtat ttgactccaa ccagccggga catgaagcat 673681 acgcaggaca ggggaaccac agcttgagcg tggcggacgt cgacggagac ggaaaggatg 673741 aaatcatata cggcgcaatg gctgtcgatc atgacggaac cggcctgtac tcaacgggcc 673801 tcgggcacgg agacgcgatg catgtagggg atctggaccc gtcacgaaaa gggcttgaag 673861 tgttccaggt gcatgaggac gccacgaagc cgtacggact gtcgctgcga gatgccggaa 673921 ccggtgagat attatggggc gtccatgctg gaactgacgt tggccggggc atggcggctc 673981 atattgatcc aagctacaaa ggatcgctcg tctggggaat tgatccgccg ggcaatgatg 674041 gcatgtcgta cgggcttttc acgagcaaag gcgaaaaaat cagcgacaaa gcgccctctt 674101 cagccaattt cgccatctgg tgggacggtg atttggtcag agaactgctt gatcatgact 674161 gggacggaac gatcggcagg ccaaagattg aaaaatggga tgctgaaaac ggctgtctga 674221 agacgatatt tcagccggcc ggcgtgttgt ccaacaacgg cacgaaagga aacccggttc 674281 ttcaggccaa cctgttcgga gactggcggg aagaagtgat atggagaacg gaagacagca 674341 gcgcgctccg tatctataca acaacacatc tcacccgcca ctgcttttac acgctgatgc 674401 atgatccggt ttacaggctc ggcatcgcct ggcagaatac cgcctacaac cagccgccgc 674461 acacgagctt ttacctcgga acgggaatga aaaaaccgcc gaagcccgcc ctgtacatag 674521 cgggaagcaa agcggaggcg ccgctgtagg aggactaagg gataagacgc aaaggctgaa 674581 cgctacgcca agatgattag agaactggca ggacgaacca atgctcaagc gctgtacgca 674641 ccggtttttt caagggaaga gctatccgtg atggaagctg tataaaaaac gaggaggaat 674701 gaaaaaatgg caaatcatat ttatcttgcc ggcgattcga ctgttcaaac gtatggagac 674761 agcacaaatc aagggggctg ggggcagttt ctcggctcgc atctgccgga gcatattcaa 674821 gtgatcaaca gagcgatcgg gggaagaagc tcgaaaacat ttgtggaaga gggcaggctt 674881 caggcaatcc tcgatgtgat tgagccggat gattggctgt tcgtgcagat gggccataat 674941 gacgcgtcaa aaaataagcc ggagcgctac accgagccct atactactta taaacaatat 675001 ttaaagcagt atatcgcagg cgcgcgggaa aaaggcgccc atccgcttct cattaccccc 675061 gtagcccgct ttcattacga aaacggcgtg tttttgaacg attttcctga ttactgcatt 675121 gccatgaagc agacggccgc tgaggagaat gtccagctca ttgatctgat ggagaaaagt 675181 ctcgctttct ttactgagaa gggcgaggaa aaagtgtaca cctattttat gatttcagaa 675241 gggattaacg attacacgca ttttacaaaa aaaggcgcaa atgaaatggc gaaacttgtg 675301 gcaaaaggca taaaggagct cggcctgcca ttgacagaat cgatcatcaa agaaaggtga 675361 aaatgtgatg agaaaactgt atcatggcgc ttgctattat ccggaattat gggatgaaga 675421 gacgattcag caggacattg acatcatgcg tgaagttggc gtaaatgttg tgcggatcgg 675481 cgaatttgcc tggtcagtca tggaacctga agaaggaaaa attgacgtcg gttttttcaa 675541 agaaatcatc gcccggctgt atgatagcgg gatcgaaacg attatgtgca cgccgacgcc 675601 taccccgccg atttggttct cacatggccg gcccgaacgc atgcatgcca atgaaaaaag 675661 agagatcatg gggcatggct cccgtcagca tgcctgtacg aacaacccgt atttccgaaa 675721 aaaagccgcc atcatcacca cagccatcgc caaggagctt ggccggctcc cggggctgat 675781 cggatggcag ctagacaatg agtttaaatg ccatgttgca gaatgcatgt gtgagacatg 675841 cttgcgccta tggcatgact ggctcaaaaa tcgctacggg gtaattgagc gcttgaatga 675901 agcttgggga accgatgtgt ggagcgagac ctatcagacg tttgagcaag tcccgcagcc 675961 gggaccggcc ccgtttctgc atcatgcctc tctacgcact atgtatcagc tgttttcgat 676021 ggagatgatc gcttcgtttg cggatgaaca ggccaaaatc atccgctgct attcagatgc 676081 gccgatcacg cataacggat cagtcatgtt cagcgtggac aatgagcgaa tgtttcagaa 676141 tctcgatttt gcctcctatg acacgtacgc ttcgcaggaa aacgcctctg cctttttatt 676201 gaactgtgat ttatggagaa atctgaaaca agggcgcccg ttttggattt tggaaacgag 676261 tccgtcgtat gccgcctcgc ttgaaagctc cgcttacccg cacgcagacg ggtatttgca 676321 ggccgaagcc gtatcgtcct acgccttagg gagccagggg ttttgctact ggctatggcg 676381 acagcagcgt tcaggcagcg agatttccca cggttcggtt ctcagtgcct ggggcgaacc 676441 caccatcggc tatcaaaatg tgctggcggt tgagcgggca agaaaggaaa tcgagcctat 676501 tattctatcg actgaacccg ttcaagccga ggcggcgatg acttactctg acagagcaaa 676561 agcatttatt aaaactgagc ctcaccgggg actccggcat cgttcgcttg tgacgcattt 676621 ttatgaacgt attctcaaca cggggattca ccgtgacctt attccggaag gcgctccact 676681 ggacggctat cgcttgctgt ttacgccatt tgtgccgtat ttgtcttctg aatttatcaa 676741 aaaagcttcg gcattcgctg aagcgggcgg catctggatc accgggccgc tgacaggagg 676801 acgcacatgc gagcatacca ttcataccga ttgcggactt ggcgaacttg agaaaacgtc 676861 agggatcaaa acacttttta cctttccgat gaatgagaac gtgaatacag gaaaagcgtt 676921 tggcatcacg gcgccgctcg gactgtggag cgcggtgttt gacacagaga gcggaaacac 676981 ccttggcacg gttgaagcag gaccgggggc gggccatgct tttctgacgg aacggaatta 677041 cggcgagggg aaaattgtca tgctgggctc gcttccatcc gggaaagaag gggatgcgat 677101 gctggaagcg ctcgtcaggc attatgcgga ggaagctgtt atttccagcc ggtcggatgt 677161 gacacccggc acgatcgttg ccccgcgtat aggcgaaaac ggccttgtgt ggatcgttgt 677221 gaatatggat ggaaaaggcg ggagcgtgac attgccggaa tcgggaacgg atttgttgac 677281 gcaccgcttg gaaaaggcgg ggagactggc ggtcggaccg catgaatacc gtgtgattca 677341 atttgacaat cacagctgat tctttgtatc gaatcagctt ttttctatgg agggagagac 677401 agatgaaaaa gatcaaatgg ttatcaggac agccaaaggt gacaagcggc gtgacgtggg 677461 gcatgccatg gaaaaaagga gaattaaaaa aaggagaccg tctggcgctt atgaatgaaa 677521 acgcggaaac gcgatatgtg caaagcgaac cgtcggccta ttggccggac gggagcatca 677581 agtggacgaa gcacgcggcg gtgtttggcg gtcaggaaaa ccaaagcttt acagtgcaca 677641 aaagagaagt gccgcagcca actgaatcgc tcagcattct tgagacagag catgatatcc 677701 aagtggatac aggagcactc gtttgtacca ttcataaaac aggatctgat ttcattcaat 677761 cattgcagat caatggaaag ccgatcgccg caggcgggag gctcgttgcg ataagagaaa 677821 cgagaaaaga gtcagcggcg aaaatggttc ttttgcatga aaggtctgtc agctttatca 677881 aacgggcggc gattgagcag agtggtcctg tcaaagcagt agtcaaaatc gagggagtgc 677941 atgtgcttca taaaacgtat gaggaatggc tgccgtttgt catccgatta acgttttatg 678001 ccgggctgtc tgagatcggc cttgtgcaca cgcagctgat tgacaggagc ggtaaactag 678061 aattcgttaa ggggctcggc atcgaattcg accttttttt ggagggagag ccgtacaacc 678121 gccatttccg ctttgcggga gagaaaggga tgtataaaga acccgcccag ctgtttggca 678181 cacgtaaatt caatgaacga tatccgcttt atgaaaaaca aatcaatggc gaaatgctgt 678241 ctccagatga agagcataag gaatggtttg cacatggcac acagaatgcg gtttgggacg 678301 atgtcaagat cgtgcaagat tccagcgatc attacagcct gtcaaaacgg accggaaaag 678361 attatgcgtg ggttggaatg ctgcatggca gccgggcgaa ggggctctgc tatgcgggcg 678421 gaaaaaatgg cggtgtggct ctcggcctgc ggtatttctt tgagaaatat ccttcagcac 678481 tggaaatcac aggtcttgcc ggcagccgcc ccaaaatgac tatctggctt tggcctccgg 678541 acggcgaagc gatggatttg cggcattata caggaaacac tcacgtggcc agcgcgtatg 678601 aaggctttga tgaaatgcgc tctgatccga caggcattgc gaacacaaat gaaataagcc 678661 tggcgtgctt ttcgcacatg ccgtctgacg aagtcctcaa tgcgctggct gacaaatggc 678721 aggcgccccc gctcattgta tgcgagccgg acgtctatta cgaatcaaaa gcactcgggg 678781 tatggagcat cattgacaca tcccatccgc tcaaaaaaga gctggaagaa cagcttgatg 678841 cggcctttct gttttataaa aaggaagtag agcaacgcag atggtacggt ttttggcatt 678901 atggcgatgt catgcatacg tatgacccga tccggcatat gtggcggtac gatctcggcg 678961 gatacgcatg gcaaaacaat gagctcgttc cgaccctatg gctgtggcag gcgtttttcc 679021 gctcaggcag agaggatatc ttccgaatgg cagaagccat gacccgccat acgagtgaaa 679081 cggacagctt tcacctcggt gaatatgccg ggcttggctc acggcataat gttgtgcact 679141 ggggatgcgg ctgcaaggaa gcgagaatca gcatggccgg gcttcataaa ttctattatt 679201 atctgacggg tgatgaccgg acgggagatc ttttgacaga agtgaaggat gccgattatg 679261 cccttgtcaa aaccgatccg atgcgcgctt tttacgagaa aggcaagcac ccgactcacg 679321 ccagaacggg accggactgg gcggcgtttt gctcgaactg gctggcggaa tgggagcgga 679381 ccgaaaattc ggaatatctc aaaaaaatcg aaacgggaat caactgtctg aagcggctgc 679441 cgctccgctt attatctggc ccgacatttg aatatgatcc ggcgacctcg atgcttcatc 679501 atatgggaga cggcattgcg ggcggatatc atatgatcat tgccttcggc gcgccgcaag 679561 tgtggatgga gctggctgag cttcttgatg actgggaatg ggaggatatg ctgagtgaat 679621 tcggcgaatt ttacacactc agtgatgagg aaaaacgaaa aaaaagcgga ggcgctcttc 679681 atgacgggca ttttcactgg ccgatgttcg ccgccggtat gacagcctac gccgcaagaa 679741 aaaagcaaga tcctcatctc gccgccaaag cgtggaatct tttgctagaa gataagctca 679801 gccatacgcc gcttccgatc aaaccggagc gcatcgagac atggacgcag ctagaggagc 679861 ttccatgggt gacaacgaac actgtctctc aatggtgttt aaatgtcata gcggcgctgg 679921 aactgatcgg agattccctt ccggcaaaaa aagaaacatc gggcaaaaaa ggataacagc 679981 cggaatttca taggagaaat ggtgcaaaaa atgaagattg caagaattta tgtaagcgct 680041 ttatattgag aggggcaaag gggaaatgca aattgaaaaa agggggactt acgcaacatg 680101 aaaataagaa tgcgaaaaaa atggatggcc ttgccgcttg ctgccatgat gatcgccgga 680161 tgcagccatt cggaaacatc caattcagca agcggttcga aagatacgat caaaattatg 680221 gcgccgctct tatcgccgga aagcccaagt gataagagcc cttcattaaa agcgctcgaa 680281 aaatacacag gcaaagagat taaggtcaca tgggtgcctg attcatccta caacgacaaa 680341 ttcaacatcg tcatggcttc aggagagatg cctcacgcga ttgtcattaa agataagtca 680401 gccggcttta tcaaatctgt caaagcaggg gcgttttggg agctgtctcc ttatttaaaa 680461 gactacaaga atttaagcca ggcagatgaa aagattttga agaacagctc ggtgaacggc 680521 gaggtgtacg gaatctacag aacgagggat ctgatcaggg cgtgtatgat catcagaacc 680581 gactggctga aaaatgtcgg tctggatatg ccggaaacgc ttgatgattt ctatgaagtg 680641 ctgaaagcct ttaaggaaaa agatcctgac ggaaacggca aggatgatac gtacggcatg 680701 gtcgtgccga aatggatggg actcggcaac ggaagcccat gggatgttct gcaaatctgg 680761 ttcggcgctc cgaaccgcta cggtgttgaa aacggaaagc tgattccaga ttttacaacg 680821 aaggaataca tggatgcgct cacgtttttt aaaaagctct atgatgaggg cttgatcaat 680881 aaggactttg ctgtcatgga ttctgcgaag tggaatgatc cggttgtaaa aggaaaagcg 680941 ggtgtcatcg ttgatacagg ctcaagagcg tctcaaatcc aaagcgcgat ggaggaggcg 681001 gatgagtcga acaaggatat cattgatatc gtcggctcgc ttgagggacc gaatggcaag 681061 cgcaccttcc cgacatctgg ttattcaggc atgatcacga taccaaaatc aagcgtcaaa 681121 accgaaaaag agctgaaaga ggtgctgtcc ttcctcgata agatgaatga taaggaagcg 681181 cagattctca cgaacaacgg agtgaagggc cgcaattacg agctcaagga cggcgtattc 681241 acctcacttg aaaaaaacaa taaatctctc ctgtatgagc atgaaggctt ggcacagttc 681301 agcatgtcga ttccgaaaag cgagtattac atcgaagacc agaaaaccaa gctcttccag 681361 catcgcaagg acatcataac cgaaggagaa aaaatagccg tctttaaccc tgctgagtcg 681421 cttgtatctg atgtctatac ccaaaaagga gcccagcttg acaacatcat cctcgacgcg 681481 agaacacaat ttatcattgg agaaattgat gaaaaagggt tcgatgatgc ggtggagctt 681541 tggaaaaaaa gcggcggcaa tgaactgatg aaggacttga acaaattgta ccaatcgtca 681601 aaataaaccg atgcgcctgc ctttcggcgg gcgccccggt atcacgaaag gagaacagat 681661 atggaaacag tgccgaagaa gagagatgca cctgttctca ccgctggaaa aggcatcagc 681721 tggatggctg cgctcaaacg ggacaaatgg ctttatcttc ttcttattcc cggtctgctt 681781 tatttcttga ttttcaaata cttgccgatg tggggtgtgc tgatcgcttt taaagactat 681841 tcgccatatc tcggcttctg gaaaagcgaa tgggtcggct ttgattattt caaagacttt 681901 tttatgaatc cggatttttt ccggctgctg cgcaacaccc tcatgctggc gagtctggat 681961 cttttgtttg cctttcccgc gcctctcatt ttggctctgc ttttgaatga ggtaagaaag 682021 gccgtgtata aaagatgtat ccaaaccttt atttacgtac cccattttgt atcatggaca 682081 attgtggtca gcatcacctt cgttttcttt actgtcgata caggtgtgat caacaaattg 682141 attatgagcc tgacaggtga gcagatttct ttcttgtcgg atgcagactg gttccggcca 682201 atgattgtga tgcaaagcat ttggaaggag acaggctggg gaacgattct atttttggca 682261 gcgcttgcta cggttgatca agagcagtat gaagcggcca tcatggacgg agcggggcgg 682321 ttcaggagaa tgtggcatat tacgctgccg gcgattagaa gcaccattat cgttttgttg 682381 attttaagaa tcggcagctt tttgaatctt ggctttgaac aggtgtattt gatgacgaac 682441 tcactcaacc gcagtgtggc tgacatcttc gacacgtatg tgtacatgat ggggattacc 682501 caaggggcgt atagctacag cacggcggtc ggtttgttta aatcagttgt cgggattatc 682561 ttgatttttg gcgccaatta cattgcgaaa aagtttgatc aggaaggatt gttttagagg 682621 agggagaggt atggctgaaa ttcacacgat gcacaacacc aaagccggac gggtgtttga 682681 cgtctgcaac attctgtttc tcggcggtgt cggcgcgatt accattttgc cgtttttata 682741 tattatcgcc ggttcctttg cgacagaagc ggaactcgcc cagcggagct tctttatttt 682801 cccgaaaacc tttacacttg atgcttacaa gtatgtgttt tcgacaccga cgttccttcg 682861 aagcatgggc gtgtccatct tcatcacggt ggttgggacg gctgtacagc tgttttttac 682921 cttcacgatg gcgtatccgc tggcgaaacg gcatgtgaag ggacggaatc tgctgttgaa 682981 tctggtgatt ttctccatgc tgttttcagg cggcatgatt ccgacgtacc ttgtcgtaaa 683041 atcacttggc cttttggata cgtattgggc attgattctg ccgatggcga ttaatccgtt 683101 caaccttatt attatcaaaa acttctttca gcagctgccg cgcgagctgg aggaatcagc 683161 aaaaattgac ggctgttccg aaatcggcgt cttctggcgg atcgccctgc ctctgtcaaa 683221 gccagttatt gcgacctttg cgctgtttta tgcggtcggg atttggaatg atttcttcca 683281 cgctctctta tatatcaatg acagtgcaaa atggccgctg caaatggtgc ttcgccaagt 683341 cacaatttta tcggatttaa cggcgaccaa tggtgatacg atgcaaaatg cagttccgcc 683401 ggagcaggga attaaactcg ctgtcattgt cattgcgacg ctgccgattt tggcggtcta 683461 tccattttta caaaaacact ttgcaaaagg aatgctgatc ggttcggtga aaggctgaga 683521 aagggagtgt ttcatatcag tacattagat cagattaaga ttgcctatat cggcgggggg 683581 tcccaaggct gggccagaag cctgatgagt gatttgtcga ttgatgaacg gatgtcaggc 683641 acggtggcgc tctatgatct tgattttgaa gccgctcaga aaaatgaagt gatcggcaat 683701 cacagcggga acggcagatg gagatatgag gctgtttcta ctttgaaaaa ggcgttatca 683761 gccgcggata tcgtcattat ttccattttg ccgggatcac tggatgatat ggaagtcgat 683821 gtgcacttgc ctgagcgctg cggtatttat cagtctgtag gtgatactgt cgggcctgga 683881 gggatcatca ggggcttgcg tgctgtgccg atatttgcgg aaattgcccg ggcaataaga 683941 gactacgcac ctgaatcatg ggtcattaat tatacaaacc cgatgtctgt ctgtacaaga 684001 gtgctgtata aagtgtttcc cggcatcaaa gcgattggct gctgccacga ggtattcggg 684061 acgcaaaagc tattggcgga aatggtcacg gaaaggctgg ggattgaggt gccgcggcgt 684121 gaggatatcc gcgttaatgt gctcggcatt aaccatttta catggatcac aaaagcctct 684181 taccgccata ttgacctgtt gcctatattc cgtgaattca gcgcgcacta tggggaatca 684241 ggatatgagc tggaggggga atgctggagg gacagcgtct tttgttcggc acaccgtgtt 684301 gcgtttgatt tatttgaaac gtatggcgcc atccctgctg cgggtgacag gcatctggca 684361 gagtttcttc ccggcccata cctcaaacag cctgaagtat ggaaatttca tctcacacct 684421 atatcattca gaaaacaaga cagagctgag aaacgacaag aaacagaacg gttgatcgtg 684481 caacaacggg gcgttgctga gaaagcttcg ggagaagaag gcgtgaacat catagcggct 684541 cttctcggat tgggtgaact cgtcacaaat gtaaatatgc cgaatcaagg ccaggtctta 684601 aaccttccta tacaagccat tgtcgaaaca aacgcattca tcacaaggaa ccgtgtccag 684661 ccgattttgt ccggagcgct tccgaaaggt gtggaaatgc tggcggctag gcatatatcc 684721 aatcaggagg cagtggcgga cgcaggttta acaaaggata ctggcctcgc gtttcaagcc 684781 ttcctcaatg acccgcttgt ccagattgac cgcagtgatg cagagcagct tttcaatgac 684841 atgctccaat gcatcatgca aagctgagct tgccgattag ctctttccgg tttagaaagg 684901 aaagcattga ccatactgat agtataatca agaagtaggt gctatcaata tgggaaatta 684961 tttaagtgtt gcggtagaac tggtctgcgg tttaggcatt ttatttatca tcttaaagct 685021 tctcgggaaa acccaatttt ctcaaattac gccgtttgac tttatttctg ctttaatttt 685081 aggtgaattg gtcggaaatg ccgtctacga tcatgaaatc aaaatcaaag aaattatttt 685141 tgcttcgcta ttgtggggcg tgctgattta tattattgaa tttatcacgc aaaaaatgaa 685201 atcatcgcga aagttcttgg agggcgagcc gaatatcgtc atccgcaaag gggagcttca 685261 atataaagta atgaagaaaa ataagataga cattaaccag ctgcaaagcc tattgaggca 685321 agctgggagc ttttcgatcc aagaagtaga atatgcgatt cttgaaacaa acgggatggt 685381 cagcgtgctt ccaaaatcag actttgacaa accgacaaat aaggatttgc agattccttc 685441 gaagtccgtt tctctgccga tcacgttaat catagatgga gagattgtgc gggataattt 685501 gaaggaagca ggtgtggatg aacagtggct gaaacaagaa ttgaaaaaga agaacattga 685561 taagacagag gacgtgttat ttgcagaatg gcataaaaat aagccgctgt atactgtaac 685621 gtacgaacaa agcagatcaa catgactctt agaaaaaagc ttgcagcaag gcgcaagctt 685681 tttattgatt gtatgtccct tgtttgacag cacgtacatg gtacatgctc acttcagtgc 685741 tgatcagata gtcaggcttt ggtttgcctt tgtttgcttt atggccggcg atatgcgcat 685801 cgcttttttc ccattgcttc cagtgatcct ctgattccca gcgaatcatg acaacaactt 685861 cttcatcacc gcggcgcaca tttttctcaa gcactgtcac atcaattaaa ccttcttgtt 685921 tttcaatgat tccttcagcg ctgaaacgtt ctatgacttt atctgcaaag ccttctttaa 685981 ccgtcatttt tctcaactgt acaaacattt gtctcactcc aatcattctc acatatgaat 686041 aattgtaaat gaaattcatt ctcaatgtca aagaaagcgc agggcggaat cgaaccgccg 686101 tgcgcaacag tttattcttt taataaaaac acatttccgt cttcgtcctt aaattgaacg 686161 aaggtgcccc actccatttg attgggctca ccgagaaatt ctacaccgtt tgtcttcatt 686221 ttctcgtatg taccaaagat gtcttcgcat tcaaacacaa tagaagcctt catttgctct 686281 gagcctttca tcatggcttt cgggtaaatg actaaacgag tctcggctcc ttttggcgca 686341 acctccagcc agcttgcttc aggtcccatt gggtgatccg ctgcaatatc aaagcctacc 686401 ttctctgtcc aaaattgctt cgctttctgc tggtcctcga catatacagc aacagtgcca 686461 atttgtttga tcatagggaa acctccaagt tgaaaagata ataatactat aacctgttta 686521 cggccgaagt aacataaaaa aatcagccgg gaaaccggct gattattaaa atgagcagct 686581 tacaacatcg atgtgatttg tgtctaaggc gaaataaacc cagcggcgcc gtgaggaatc 686641 ccaataaaag ccgccgacgg atcttctgcc aaggatgatc gggtaaaacc aaaatgagcg 686701 gccattggtt aaccagacat aggtaaatcg gaaaaggcaa ggacgaatgg tgattggttc 686761 aactaacaaa acggctcctt gagaaccctg cggttttggg ggtttcgctg gtatttggga 686821 aggaggaggt ccctgcggcg caccgccgaa gcctgggctg gcaccgctgc caataccagg 686881 gccggagccg ccgccaaagc ctggaacagc accaccgcca atgccaggac cggagccgcc 686941 gccagagccc ggaacagcgc cgctgccaat gccaggccat ggatatcggt attcatattc 687001 aaaagcaggc caaggctcat aaaaatgccc cgcaaacata taaggatcaa cataatacat 687061 gtgataacgt cctttctcat tgtaaactgt acattgcagt ttatgcgggc ggactcttat 687121 tggtgcattc gcctaaggat atgaagctgg aatgctctca gagagcagaa tcatttgatt 687181 tttctctagt cttattcaca attccgattt atcattttat aatgaaagtg cttctattac 687241 gaaaaaggag acagaccgtg aatatcgatc aattattata tcaatatatc atagacaaca 687301 ctgcggatat tactgagaaa tggttcagtt tgcgttgcca gctaaaaggc gagctatatt 687361 ccgccagcca tttaagtgaa gaaacgaaaa cacttttaac cgagcagcat acatttacca 687421 atataacaat cgcaagcgca tttctggagg atcaaaccga ttttcaagaa aacatgacaa 687481 aatgggcgca aaacgttgcg aaaaacaggg tagagcagga tgttcaagtg catgaggtcg 687541 tagaagccat atccaattca agaatctcat tctgggacgc agtcgccaca tttataaaag 687601 agaatcagga gattgtgaca aatgaggatg cagaccgatg gaaccgcatt gtgaatcagt 687661 cgttcgataa gctgattatt gaattctccg agcagtacca aaaattcatg ctgatgaggc 687721 ttacatctca gcaggaactg atctcagagc ttggctgccc ggtcatttcc attgccgatg 687781 gaatcgggat attgccgctt atcggctcca ttgatacaaa acggcacagg tcattttaga 687841 aacagtgccg gtccgctgtg tcgagagaaa aatcacaagc ctcgtcgttg atctttcggg 687901 tgttccgatt gtggatacca tggtggctca gcaattgtac aacctgtcta aaacactttt 687961 cttattaggc gtcaaagccg tattttcagg aattcgcccg gatgtggccc aaacatcgat 688021 tcaattgggg cttgatttta gtgaatatga aacgtacggc acgctgaagc aggcattaga 688081 aaacatgggt gtccgctgta ttgttgagga attggaagaa aacaaatagg aagtttccag 688141 gcatatgatt gtccgtcacc gggtgatcat atgccttttt gatttgaaca gaaatcacca 688201 ttgatttatc gaaaaaaaca taatattata attcttataa gaatactgtg aattaaaacc 688261 tattcaacag gggggaaggt cttttggttt ctaaatcaac gattgatccg gaagtgattg 688321 aaaaaatcat cagctcgctg gaaacactcg atttcggcac ggttcagatt acggttcatg 688381 attctcagat tacccaaatt gagaaaatag aaaagcaccg tttttcgctg aaaaggaaag 688441 aatcaaaatg ataatgtaaa gggcgtttgt tttcattaaa ttctccttaa aacatataca 688501 tatttcatcc aatttttata taatagacct ttaagatcat tttttaggag gatttttgac 688561 atgcaagcta cggttcacga gagtaagcaa tcgatcatgc aacgcatttt gacagtcttt 688621 gtcttcacat tgctgatcgc gactgtcggc ctttttatcg gccaatttgt tcctgtcgct 688681 ttgatgctgc cgctttctat tcttgaagtg gcgatgatta ttctggcctt ctggatgcgc 688741 agaagaaaag cggtcgggta tgcgtttgta tatacattcg cgttcgtttc cggcattacc 688801 ttatttccga tcgtcagcca ttacgcttcc atcgccggcg cctatgtcgt gctcgaagcc 688861 tttggctcta catttgtcat ttttgccgtc ttgggcacaa tcggcgcaaa aatgaagaag 688921 gatttatcct tcctgtggtc gtttctgctg gttgcggtgc tcgcactcgc agtggtaggg 688981 attttcaaca ttttcagccc gttaaactca gcggcgatga tggcgtattc cgtgatcgga 689041 accatcgtct tttcccttta cattttgtat gatttgaacc aaatcaagca ccgccacatt 689101 acggaagact tgattccggt tatggcgtta tcgctgtacc tagactttat caacttgttc 689161 atcaacctgc tccgcttctt cggcattttg agcagtgatg attaatgaaa aagcgtctgt 689221 cattggatag gcgctttttg ccatacatca aaaaggcagg tggagtattg gtgaaaaaac 689281 aaatgggcgc atatgtatct ctggcagcag ctatggcgat cgtcggcagt tctgtcgttg 689341 tcggcaagct gatggtcgaa cggattccgg tctttctttc ctcaggattg cgttttttga 689401 tcgcttctgt cgtattgctc atgctgctgt tttgcattga aaaagggttt ccggctttga 689461 cgaaaaaaga tgtgttcgta ttactggtgc aatcattcac aggcgtgttt ttgttcagta 689521 tttgcctgct gtatggggtt caatatacga cgggaacgga aagcggcatt ttgacaagca 689581 caacccccat gttgatcggt attttatcct ttttcctgct gagagaaaaa attgagaaaa 689641 agacgctgat cggcattttg ctggcggttt gcggcgtaat ggcgattaat ttgtttggag 689701 ccgggagcca agacgggacg ccgcacgcct tattcgggaa catgctgatc attgctgcag 689761 tcattggcga agcgttgttt acattgatgg ccaagctgct atccccgcat atttcggcac 689821 tggcgatttc gaccttcgta tcgctcttcg gcttcctgtt ttttctcccg tttgctttgt 689881 ttgaggcctc ttcatttgat tacagcgtgc cgactgtttt ggattggtcg tatgtgctgt 689941 attacgcgct ttttgtcact gttttggcgt tttacttatg gtatagcggg gtgacgaagg 690001 tgccggcggg tgtatcgggc attttcacat ccgttcttcc ggtctcagct gtcattttgt 690061 caggcgtgat attgaaggag ccatttgagt ttgtgcattt catcggcatt gcatgtgtca 690121 tcggcggcat atttgttacg gtcataaaga aaaaacagcc ggatgcgtat ccggctgcag 690181 aagaaaagac gctatagcct gtccggatcg gacgggtttt ttagtcttta aacacgctca 690241 gcctttcaaa aagatcacca agcatcttca cgaacatgtc tttttcctcg tcgctgtagt 690301 tttccatgac agcggatatt ttgctgaaat ggccgggcag aaattgctcc aggcgtgctt 690361 tgccttctgt tgtcagttca atgctgattt ttcgtttatc ctctgtgtga tgcctgcggc 690421 tgacaaaacc gtctctcgcc agcccgtcta gcaggcctgt aattgttgct ttcgtgacat 690481 ttgaccgctt ggcaagctct gtcggactta acctatgatc cttggcatca aagagcagca 690541 tcaggatttt gaattttcct tctgaaagcc ctcggccagc aaagtaatgc tccatcacat 690601 gattcatttt ttttgaaata tcaaaaagag ataaaaacaa ttcaagagag ccggcgtcaa 690661 tattggcata cgtttcggcg tgctctgtta tatgcttata tttcggtaaa tgttttaatt 690721 ccatcgcaat tagctcccgt acattcgttg tgacacgatt ataaaggagg gaaaaccata 690781 acgcaacttg gcttggagat gattgacagc ttttcttggg acatagtaag gtaatatagt 690841 taggcgccta actaatacat atagagctga aaaggtggtt attgatatga aacatatgtt 690901 aatagcagga ggcggaatcg gcggcttgtc agcggccatt tctctccgta aggcagggtt 690961 ttccgtcacc ttatgtgaag cggcttcaga aaatcgaaaa acaggtgcgg ggattcttca 691021 gccgcaaaac gcactggcgg tgttgaaaga actgggcgta ttcgaagatt gctgtaagca 691081 cggctttcaa acagaatggt ttaaaacgtt tgatgaacag gggaatttgc tgtttcaagt 691141 cagtgaatcc tttttagacg attcacttcc gggacgcaat aatatcctgc gcaaaacgtt 691201 aaatgacatt ctcatgaagc atgccgaggc agtgggtgta gacatcaagt gggggaaaaa 691261 ggttgtcgcc tatgaagaaa ctgctgaatc ggtcactgcc ttatgtgaag atggagaaaa 691321 gatgcaggct gacattctgg cgggctttga cggcattcac tccgttgttc gtgataagat 691381 gctgcaaaag gaaacggaaa aagagcatct cggcatggga gcgtggcgct tttatatcga 691441 acttcctgat tacacattcg aggacgcaac attcatgtat agaagcggag acacacaaat 691501 cggggtggtg ccattggcac aacacgctgg ctatgtcttc gtcctccagc cttgcacgag 691561 cgattactgg gatgaggaag atacccggtt tgatagagta aaagagattc tttctggttt 691621 tcgggggctg gattttgtca caaagcacat gtcaaaacag catcctgtca tctttaacaa 691681 actggagcag gtcgccgtgc aggagccatg gcataaaggc cgcgtcatca tcggaggaga 691741 cgccgcccac gccggtgcgc caaccctggc acaaggagcg gcaatggcga tcgaggatgc 691801 catcgtcctc gccgaagaac tccaaaacca cgccgaccac gaaacagcat tacaggcgta 691861 ctataaaaga agagccccac gagcgctcaa agtccagaac ctatcatctg aaatcgtccg 691921 ccgcaggctg aaaggagagc cgggagcgga agaactgatt ggggagtgct atgcggtgtt 691981 gagggaaggg tattaaatag gaaaagtcca gaaagtgatt tctggacttt ttagtcttgc 692041 tctgttttat tccttatccg ctcaatcacc tcatgcagcc cctcaggctt ataaaactcc 692101 accggtgaac tgcctttctc aaacgaaatc gtctcggctt caatcagcgc gacatagcgc 692161 ccgtttactt ttgcgagatg aatagaatcg ccaaaatccg ctagcaatcc cttaatctct 692221 gtttctccga ctttcatttt cagctgggcc tctggcgtgt gctcgatgat ttgggcggag 692281 gcttcgatga cttgatgggt gtcgaggcgc tcttggattt cccgtttttc gcttgcttcc 692341 caaatctcaa tgtcgtgctc gaactgcttg agttcttcgc tgttgtcttc aaatgtctcg 692401 tagacgtgct cttgtaccat gttcatgacc tgatttttca tgatttctgg catcgattct 692461 ccgtactcga cgaatttcag aaagtcctca aaatagcggg cgtgcgaggc ctggtggatt 692521 ttcagttcac cttcctcgac cattccttcc tctggcatgt acgggtattg gatgcttttc 692581 atgttttttg tcgtgatcgc catttcgact tttttaatga gagaagacgc gtcagagatg 692641 cgggcgacct tcggctcaaa atcacatttc ataatgaaga caaatgactc atcaaagtat 692701 tttctcggca cggccgaagc gacgagaaac acgccgccgc gaaccgcgct tgtgtcaagg 692761 tacgtgcgga cgaactgctc gctcagctca ttgaagtctt cttttgtttc cgccagacgc 692821 gcgcggttga acatgttgta gtttgggttg gaatcgagct cgtggccggg ctcgacgata 692881 aaatggccga ttttcgtcgg cacctgctcg gactgcggat ggcggtcggc tttccgttta 692941 acgatttttt tcagttcccc gtcgagaaag tccttcagct cgctttcttc aaattctccc 693001 gtatcaaggg tctggaagtg cttgaactgc ttgttcgcct gctcatcttt gccttccacc 693061 tgtatgacat aaaaggataa aaaccgaatt tcaaaatcca tatataaact caccttattc 693121 gcgtattgta cagcttctca agtatagaaa aaacagcgat catgcgtcaa ttgggagaac 693181 ggaataatca tgaccatgaa agggaaatgt agtcaaatag aaggcatttc atacggaaag 693241 gaatggttcg atgaaggaaa caagcccgat tcctcagccg aagacgtttg ggccgctcgg 693301 caatttgcct ttaattgata aagacaaacc gacgctttcg ctgatcaaac tggcggaaga 693361 acagggcccg atttttcaaa tccatacacc cgcgggcacg accattgtag tgtccggcca 693421 tgaattggtg aaagaggttt gtgatgaaga acggtttgat aaaagcattg aaggcgcctt 693481 ggaaaaggtt cgcgcatttt ccggtgacgg attgtttacg agctggacgc atgagcctaa 693541 ctggagaaaa gcgcacaaca ttctgatgcc gacgttcagc cagcgggcca tgaaggacta 693601 tcatgagaaa atggtcgata tcgctgttca gctcattcaa aaatgggcaa ggctcaaccc 693661 gaatgaagca gtcgatgtcc cgggagatat gacccggctg acgctcgaca ccattgggct 693721 atgcgggttt aactaccgct ttaacagtta ctacagagaa acgccccacc cgtttatcaa 693781 cagcatggtg cgggcgcttg atgaagcgat gcatcaaatg cagcggcttg atgttcaaga 693841 taagcttatg gtcagaacaa agcggcaatt ccgctatgat attcaaacga tgttttcgtt 693901 agtcgacagc attattgcag agcgcagggc gaatggagac caggatgaaa aagatttgct 693961 cgcccgcatg ctgaatgtgg aagatccgga aactggtgaa aagctcgacg acgaaaatat 694021 ccgctttcag atcatcacgt ttttgattgc cggccatgaa acaacgagcg gcctgctttc 694081 ctttgcgact tactttttat tgaagcatcc tgacaaactg aaaaaggcgt atgaagaggt 694141 cgatcgggtg ctgacggatg cagcgccgac ctataaacaa gtgctggagc ttacatacat 694201 acggatgatt ttaaatgaat cactgcgctt atggccgaca gctccggctt tcagccttta 694261 tccaaaagaa gacacagtca ttggcggaaa atttccgatc acgacgaatg acagaatttc 694321 tgtgctgatt ccgcagcttc atcgtgatcg agacgcttgg ggaaaggacg cagaagaatt 694381 ccggccggaa cggtttgagc atcaggacca agtgcctcat catgcgtaca aaccattcgg 694441 aaatggacaa cgggcctgta tcggcatgca gtttgccctt catgaagcca cacttgtgtt 694501 aggcatgatt ctaaaatatt tcacattgat tgatcatgag aattatgagc ttgatatcaa 694561 acaaacctta acacttaagc cgggcgattt tcacatcagt gttcaaagcc gtcatcagga 694621 agccattcat gcagacgtcc aggcagctga aaaagccgcg cctgatgagc aaaaggagaa 694681 aacggaagca aagggtgcat cggtcatcgg tcttaacaac cgcccgcttc tcgtgctgta 694741 cggctcagat accggcaccg cagaaggcgt cgcccgggag cttgctgata ctgccagtct 694801 tcacggcgta aggacaaaga cagcacctct gaacgaccgg attggaaagc tgccgaaaga 694861 gggagcggtt gtcattgtga cctcgtctta taatggaaag ccgccaagca atgccggaca 694921 attcgtgcag tggcttcaag aaatcaaacc gggtgagctt gagggcgtcc attacgcggt 694981 atttggctgc ggcgaccaca actgggcgag cacgtatcaa tacgtgccga gattcattga 695041 tgagcagctt gcggagaaag gcgcgactcg gttttctgcg cgcggggaag gggatgtgag 695101 cggtgatttt gaagggcagc ttgacgagtg gaaaaaaagc atgtgggcgg atgccatcaa 695161 agcattcgga cttgagctta atgaaaacgc tgataaggaa cgaagcacgc tgagccttca 695221 gtttgtcaga gggctgggcg agtctccgct cgctagatcg tacgaagcct ctcacgcatc 695281 cattgccgaa aatcgtgaac tccagtccgc agacagcgat cgaagcactc gccatatcga 695341 aattgcattg ccgccggatg ttgaatatca agagggcgac catcttggcg tattgccaaa 695401 aaacagccaa accaatgtca gccggattct tcacagattc ggtctgaagg gaaccgacca 695461 agtgacattg tcggcaagcg gccgcagtgc ggggcatctg ccattgggcc gtcctgtcag 695521 cctgcatgat cttctcagct acagcgtcga ggtgcaggaa gcagccacaa gagcgcaaat 695581 acgtgaactg gcgtcattta cagtgtgtcc gccgcatagg cgcgaattag aagaactgtc 695641 agcagagggt gtttatcagg agcaaatatt gaaaaaacga atttccatgc tggatctgct 695701 tgaaaagtat gaagcgtgtg acatgccgtt tgaacgattt ttagagcttt tacggccgtt 695761 aaaaccgaga tactattcga tttcaagctc tccaagagtg aatccgcggc aagcatcgat 695821 cacagtcggt gtcgtgcgcg gcccggcgtg gagcggccgt ggcgaataca ggggtgtggc 695881 atcaaatgat ttagctgagc gtcaagccgg tgatgatgtc gtgatgttta tccgcacacc 695941 ggaatcccgg tttcagcttc cgaaagaccc tgaaacgcca attattatgg tcgggccagg 696001 cacgggagtc gcgccatttc gcggtttcct tcaagcccgc gatgttttaa agcgggaggg 696061 caaaacgctc ggtgaggctc atctctattt tggatgcagg aacgatcggg attttattta 696121 ccgagatgag cttgagcggt ttgaaaaaga cggaatcgtc actgtccaca cagccttttc 696181 ccgaaaagag ggcatgccga aaacatatgt ccagcatctc atggctgacc aagcagatac 696241 attaatatca atccttgacc gcggtggcag gctttatgta tgcggtgatg gcagcaaaat 696301 ggccccggat gtggaggcgg cacttcaaaa agcgtatcag gctgtccatg gaaccgggga 696361 acaagaagcg caaaactggc tgagacatct gcaggatacc ggtatgtacg ctaaggatgt 696421 ctgggcaggg atatagataa agaagactgg agacatccag tctttttagt cctttcgaaa 696481 aaatggtgat cgcgctaaac attgatgcat acaataactt cagtccgccg gaagggcggg 696541 ctgtctgcaa aacctatttt tcgtttttgc tagtttatgt tattcttata ctcggtatct 696601 atttcttttt tcaaaggcac acatgacaaa agaaatcctt tttttatttc cgagaaaaaa 696661 atgtgaaacg aaatgaaggt ttctttcgtc cagtgattgg tttccaaatg gttgtaataa 696721 aaatgatatg gtgcgaaaca taaatattcc ggcttgccgc ggtgtattta ttgttgtgtg 696781 atgccttgat tttgtttgga aagaaggaat tggaaggcag gatataaaga gcaggtaaat 696841 atgaatgaag aacttaaagt gtttaagaaa gtagaggttg ccatgaagaa acttttttct 696901 tacaaactta gcttttttgt gctggctgtt atactgtttt gggcaaaaac gtatttatcc 696961 tacaagactg agtttaatct tggggtaaaa ggcacaactc aggagatcct cctgatattt 697021 aacccattct caagcgccgt cttcttttta ggactggctt tgctggcgaa agggcgtaaa 697081 tcagccatta ttatgctgat tatcgatttc ttgatgacat ttgtgttata tgcaaatatt 697141 ttattctatc gtttctttga cgatttcttg acgttcccga acattaaaca gtccggaaac 697201 gttggaaaca tgggagacgg gattttcagt atcatggccg gtcatgatat tttctatttc 697261 ttagatatta tcattttgat tgcggtattg atctggagac ctgaattaaa agaatacaaa 697321 atgaaaaaac gctttgcatc tttagtgatc ctttctggga tcgcactgtt tttcatcaac 697381 ctgcactatg cggaaaaaga ccgtccgcaa ctgctgacaa gaacgtttga ccgcaattat 697441 attgtgaaat atttaggttt atacaactac accatttatg acggtgtaca gacggctcaa 697501 acagagacgc aaagagccta tgcaagcagc gatgatttaa caagtgtcga gaattacacg 697561 acgtctcatt atgcgaaacc aaacgccgag tacttcggct ctgccaaagg caaaaatatc 697621 attaaaattc acctcgaaag cttccagtca ttcctgattg actacaagct aaacggtgaa 697681 gaggtgacgc ctttcttaaa taaacttgcg cacggcgggg aagatgtgac gtattttgat 697741 aacttcttcc atcagacagg ccagggaaaa acatctgatg ccgagctgac aatggataac 697801 tcgatcttcg gtcttcctga aggctccgcg tttgtgacga aaggcgaaaa cacctaccag 697861 tcgcttcctg cgattttaga ccagaaggaa ggctatacaa gcgccgtcct gcatggtgat 697921 tacaaatcgt tctggaaccg tgaccagatt tacaaacata tcggatatga caagttcttc 697981 gacgcaagca cgtatgatat gtcagatgaa aatgtgatta atatggggct taaggataag 698041 ccgttcttta cagaatcgat tccaaagctt gaatctctta aacagccatt ttatgcgcat 698101 ttgattacat tgacaaacca ttatccgttt aaccttgatg aaaaagacgc gtctcttaaa 698161 aaagcgacaa caggcgataa cacagttgac agctacttcc agacagcgcg ttaccttgac 698221 gaagcgcttg agcaattctt caaggagctg aaggaagccg gcctgtatga caactcagtc 698281 atcatgattt acggtgacca taacggtatt tctgaaaacc ataaccgagc gatgaaagag 698341 attcttggaa aagagatcac agattatcaa aacgcacaga accagcgtgt gccgctgatg 698401 atccgcgttc ctggcaaaaa aggcggagtg aaccatacgt atggcggcga aattgacgtc 698461 atgccgacac ttctgcactt agaaggaatt gattctcaga aatatatcaa ctttggtact 698521 gatttattct ctaaagacca cgacgatacg gtggcattca gaaacggaga cttcgtaacg 698581 ccgaagtaca catcagtcga caatatcatt tacgatacga agacaggtga aaaactgaaa 698641 gcgaatgaag aaacgaagaa tctgaaaaca agagtgaacc agcagctgag cctttcagac 698701 agtgtcctgt acaaagactt gctgaggttc cataaactaa atgatttcaa agccgttgat 698761 ccgtcagact atcattacgg caaggagaaa gaaatcaaat aagatgaaaa agagccttga 698821 gcgggcgcat tgccttcgct caaggctctt tttttggtta tacaaccaac ttgaaaaaat 698881 agattccatt tggtcaccaa ggctggcttt ctctcatatc attacagtag attttgaaac 698941 cggattgaaa tcggacaaat tatcggggaa atgccttgat agattgtgaa gatgtaccag 699001 gtttcgaact caatattcat agagatgagg ggtagagatg aaagcggtca ttctctgcgg 699061 cggaaaagga acgagaatga gtgaagtcac gaatgacatt cctaaaccgc tcgccatgat 699121 aggcggcaaa ccgattctat ggcatattat gaaaatttat cagtactacg gagtaaacga 699181 gtttattctg cttttgggct ataaaggaga aaaaatcaag gaatactttc tcgactatga 699241 atggaagcac aacagcctga cactcgacag ctctacggga gaggtacaga tgctggggca 699301 gcctgaaacg tggaaaatta cgtttttgga gactggggta gatacgctga cagccggaag 699361 aatcttgcag gcgaaagact atatcggtga tgaaacattt ctgctcacct atggagacgg 699421 gctggccaat atcaatcttt tccatctcat cagctatcat cagacaaaag gtgctgccgc 699481 gactgtcacc ggcattgaca aagtctcgca gtttggcacc ttgacagttg aggatggcat 699541 ggcgaaaaca ttttctgaga agacatcaag tgatggaatc atcaacggcg gattcttcgt 699601 tcttagtcca aaggttttcg attatttgcc gaaggacggg aacacgatgt tcgaagatga 699661 accgctgaag aaccttgcca aagatgggga gcttgctgtg taccgccatt acggattttg 699721 gacggccatc gatacgtata aaaatctctt agaagtcaac aaaatgtgga atcaaggaca 699781 acaagtatgg aaggtatggt gaattgattt gagtttctgg aaaaataaaa acgtatttgt 699841 cacgggatgc acaggtcttt taggaagcta tttggtgaaa gagctgatcg aacagggcgc 699901 aaacgttacg gggctagtca gggatcatgt gcctcaatcc aatctttatc agggagaaca 699961 tatcaagaaa atgaacatcg tgcggggctc tcttgaggac ttggctgtga ttgaacgcgc 700021 gcttggcgag tatgagatcg acacagtctt tcatcttgct gcacaagcga ttgtcggcgt 700081 ggcaaaccgc aacccgattt ctacctttga agcgaatatc ctcggcacct ggaatattct 700141 cgaagcctgc cgcaagcatc cgttaattaa gcgggtcatt gtcgcttcaa gtgataaagc 700201 ttacggcgat caagaaaacc ttccatacga tgaaaacatg ccgctgcaag gcaagcaccc 700261 gtacgacgtc tcaaaaagct gcgcagatct gatcagccac acctattttc acacgtacgg 700321 gcttccggtc tgcattacgc gctgcggaaa cttatacggc ggcggagatt tgaacttcaa 700381 ccgcatcatt cctcagacga ttcagcttgt gctgaacggg gaagcgccgg aaatccgaag 700441 cgacggcaca tttgtacggg actacttcta tattgaagac gccgttcagg cttatctgct 700501 tcttgcagaa aaaatggaag aaaacaatct tgccggagag gcctttaact tcagcaatga 700561 gatccagctg accgtacttg aactggtaga gaaaatatta aagaaaatga acagtaatct 700621 gaaacctaag gtgctgaatc agggaagcaa tgaaatcaaa catcaatatt tatccgcgga 700681 aaaagcaaga aagctgctga attggacacc ggcctacact attgatgagg gacttgaaaa 700741 aacgattgag tggtatacgg aattcttcaa aaagtaatgt gaaacgaggt gaacaagact 700801 gtgaccagcg cgtattgcac cgttttatca aaaggaagat tatatcaggc agtcgctttg 700861 tttaagtcgt tagagcaagt tgatcaagac agtcccattt ttatactttg catggatgaa 700921 gatacgcacc gcgtgttaca gaagctgaag atgaagcagc tgaaccttgt gccggtggcc 700981 gctcttgaaa atgaattgct gctgaagctg aaggaaacta gagatcaaag tgagtattgc 701041 tggacgatga agccgatctt tctgcaagct gtgctgaaca gcaatcctga gctggagcgt 701101 gtgacgtata ttgacgggga tctctttttc tatgcagatc catcgccgat ttttgaaaac 701161 cagccggact gctcggtgtt gctttcacga ggggatattg taatcccttc ttttgagaaa 701221 gagcagattg acatgctgca gcgtctttta ggcagatata attccgggtt tatcagcttc 701281 aagcatgatg atgcaggcac ggattgcttg gagtggtgga aggaacgctg tcttgaggaa 701341 tgcaaaaatg caccgggtga agggaaattc ggtgatcagg gctatttgga ttatatgtct 701401 gagctgtttc cgaatgtgtg tgacattaca acacccggcg tgaacatcgg ccattggaat 701461 tatggacagc atacgttttc ctggaaagat ggccggatcg tgctggagga tggcagtccg 701521 ctgatctttt atcatttcag cggataccga atcgtcagca tcaatgaaat caaacagatt 701581 catgaaacaa cccgcacaga tctgccgttt gtgcatgaac tgtatcaaga gacactgccg 701641 catatcattc agcacatgca aacgttagac cctgaattta acggttttgc ttcaaaagat 701701 gacaacaaat aaatgagtaa atacaggaag tgaaaatgaa gtgaaagcaa gcgttattat 701761 tcctgcatat aattcgaagg agcgtcttta caacagcctt ctgtcattaa accagcagga 701821 gtgcgatgaa gaatttgaag tcattgtagc ggacaatggc tctgaggacg ggacgctctc 701881 gatgcttgag tcatttcaag ctgattttcc gctgatcttt acacggatta aagaaaacag 701941 gggcattgcg tacggacgaa atcaggcgct tcgcaatgcc agaggagaca tcctgatttt 702001 ccatgacagc gatatgcttg cggcaaagga ccttgtggca aaacatatta aagcccatga 702061 gaacgaagag aatctcgtcg tgtgcgggtt gttttggaaa cggatctaca gtttttacta 702121 tgaacgattt gaagaagaac ataaggaaca gctcgcaaag ctcacaggtg aaatgccgaa 702181 gaaagacaaa caaaagctgc tggaggaagc ggacatcaaa aacggaagct ttcttgataa 702241 aagctttgac ctcgataccg actttataga cgtgctcaag aagattttag atgagtacgg 702301 cgatgacttg aaaggctatc atatgccatg gcgctttttt atcacgaata attcctctgt 702361 gaaacgcaag catgtggttg acctcggttt atttgacgaa ggcattgtgc ggtacgggtt 702421 tgaggattat gacctcggga tcaggcttca tcaggccgga ttgaccttca ggcttcgccg 702481 tgatattgtc agtgttcatc aggaacatcc aagcaattgt aagtctgtag acgatattcg 702541 ggcaaacatt gcctatatgt gcgataaata caataacatc cgctccttag acgttcatct 702601 cgcttttaat gggccgttcc cgcctgacat gacgaacaga atcatggctg atattcaaaa 702661 gctgctggaa tcacagaaat atgatatgct gctgaatctg tttcttgagc ttctgcatgt 702721 tgttaaagag cgcaacattg atccggattg gcgaaagaaa tccccaaggg tgacggcgaa 702781 aagctttgat ttgcaaactg tccgcaagct tctgcctaag gcgaagaaaa agctaggcgt 702841 gaacgatttt gccaacgcac tgtatgcgct tgtcaacgat ttgctgcacg tggatcttag 702901 atcattggat gtggtataag tgagtacatt tcatttttca acgatagtgt caaggacaca 702961 tatctttaag ctcatgccta tgattcattc tctccatgag cattgcgatg attttcattt 703021 atatgtgctg tgtgtcgacc agaaagcgta tgaattgctt cagcacgttc catgggagca 703081 tgtaaccttt gtgcagctgc atgaaatgga agacccggag ctgttgaaag cgaaaagcaa 703141 cagaacgttt catgaatatt gctggacgtt aaagcccgcc tttttgtttc atgtgatgag 703201 caagtgggat gacgctgaat actttgccca tatggatacg gatctatttt tcttttctga 703261 tccggcacgt atttttgcag aaaacccaac ggcgtctctg tatttgactg atcatcgtaa 703321 ttcgccgcgc ttcatgtcct actacgaccg aaccggacgc tttaatacag gctttgtcgg 703381 cgccggtaat acaaaggaag catatgaagc ggtgtggcag tggagacagg actgtattga 703441 attttgcacg gtcgaaatgg atacggaacg aaagacatat ggtgatcaaa gatatgtgga 703501 gaaatggccg gagcagttta aaggtgttca tgttgtcaaa tccataggag ccaatacagc 703561 gctttggaat atcgaaaact ataaggtcgg gcaaaaggac ggccgcgtgt atatagatga 703621 aacgccgctg attttctatc atttctctgg gtttacgctg gtgacagaaa aagagtttaa 703681 tctttgctgg tactaccgga ttgaagacga agcgacaatt aagatgattt atatgcccta 703741 tatattaaat ctgaaaagat ggattgatga aatacagtcg gcgtttccgg actttgcgga 703801 tggctttatc ccgaagcacg cagtgcctga cactcatttt atccagctgg attaaaaaac 703861 cccctgccgc ctggcagggg ttttttcagc tatgccattc tctcagcttc tggtcacttg 703921 gcaataggaa ggcaaggatg ccgaggacag ggagaaaggc aatggcgatc atcgtcgggg 703981 tcagtcccgc ggcatcaatc agagcgccca gcgccacagc gccgattgcg cccatcccga 704041 aggcaagccc gacggttaaa ccggacattg tgccgatttt tccaggaact agctcctgtg 704101 cgtagacgac cgttacagaa aagctcgaca tcagaaccaa gccaatcaat gcgagcacgc 704161 cgtaggcgag aaccgggccg gcaaatggca gcacaatcgc cagcggcgcc gagcataaca 704221 gcgaaccgag gataacgaag cgttttccaa aacggtctgc aagcgggccg ccgagaaacg 704281 tgccgatcgc gccgaacagc aagaagacaa aaatatagct ttgtgcctgc tgaatgctta 704341 cgtgataggt atccatcgcg taaaacgtgt aaaagttacc gatcgcactc gtataccaag 704401 aacgagcaaa aatgagaaat ataataataa taagagcaga tacaacagat ttggtgatgg 704461 ccgtgttttc agccgttttc ttttgcttgc ctgatttctg ggcaaggctg ccgagacgtg 704521 aggcgtacca tttcgcaata tacatgagaa acataacagc aagcgcggcg acaagcgtga 704581 accaaacagc gccgaattgc ccgagcggca caaggatcag cgcggtgatc agcggtgcca 704641 tcgcctggcc tgagtttccg cccacctgat aaatcgattg ggcgagcccg cgttttgtgc 704701 cggcggccat atacgccaca cgggagccct ccggatggaa aatggccgag cctaatccaa 704761 tgaaaaacac acagcataag atcgttatga atgacggggc aaatgcaagg cccaaaatgc 704821 caagcatgct ggcggtcaaa ccgactggca gcgcatacgg ccgcggccgt ttatcggtat 704881 accagccgac aacaggctgc atgacggatg acaccatgtt taatgtgaaa gcaatgatgc 704941 cgagctgtgt aaacgtcagg ctcatggagc gttccaaaat agggaacatg gccggaatca 705001 cagcctgaag cgaatcgttg agcatatggc aaattccgat aataatcaaa atcggataca 705061 ccgtggtgcc tggtttttga actgtttttt cttttaacgg ggcggcgata gccattgagt 705121 ctcctcctta catatataac caaagcatac caccatatta ttcataaggt gaagaattta 705181 tcaagaggaa aaaagattct tatgaaagaa ataccgtcag cctgattagc agctgacggt 705241 attttcgata ttcaaaatgt gatatagctc ttcaagctta cgaatctcat aggttggtat 705301 gatctctggc acattcggct tcatgtcagg gttcatccag caagtatcaa gcccggcgag 705361 ctgtccgcct ttgatatcag cagttagtga atccccgatg attaatgtgt gctctgctga 705421 aaattgagga atccgttcaa acacgtaatt gaaatattcc ttcatcggct tttggaagcc 705481 ggtgtcttca gaaacgaaaa tgtccttgaa gaatggaaat aatcctgaat cacggagacg 705541 cttatattgt gtgtgagaca cgccgtttgt cacgatgtac aaatcaaact gttgctgcag 705601 atttgagatg agatcaaatg caccgtcaat aagctgatgt ccttcttcaa gaaagcggcg 705661 gtatttttgc tcaagcaaag cgccgtccgc ttcgtaaccg tactccttga gcaaagcgga 705721 aaaacgtgtg tttacgactt catcccgtgt catcttacct tcttcaaagg ctctccagag 705781 accttgattg atggttttat actgcgcctt catgtcattt gttaaaggaa tgttctgatc 705841 ttcaaacagc aaacgcaggg ctaaagcttc tgccgcttga aaatcaagga tggtatcatc 705901 tacatcaaat aataaagtgc ggtatcgctt catctgtgtg tctccctttc tcatatgtat 705961 tcaaagtata gcacataaaa aaaggaaaaa gccggcgggt gaggcaccgc cggctgaaaa 706021 gagattattt gtttaataag ctgtgttttc tcgaatatag gaagtaaacc agcgttccga 706081 cagcgatcca gatgacaaat gaaagccatg tgacgccggg aaggctgtac atgaaccaaa 706141 ggcagatgcc tgcgctgata atcggcacaa ccggaacgaa tggcactctg aaggacgctt 706201 tgatttcagg atgtttcttt cttaacacaa tgacagcaat ggaaatgacc gtaaacgcgg 706261 caagtgttcc catgttcacc agatgggcca gcgttccgag gttaataaag ccggcgattc 706321 ccgctgcaac gatccctgtc agccatgtgt tgcggaacgg ggttttaaat gacggatgaa 706381 cctttgcgaa caatccaggc agaaggccgt ctctgctcat ggcaaatgtc aagcggacct 706441 gtgcgtacag caaagcgagc atcaccgtcg taatcccgat aatcgcaccg acagaaataa 706501 ttccggcaac agcgtcctgt ccgacgaatt tcagcgcaaa ggatacagga tctccgacat 706561 tcaatttggc ataaggcatc atgcctgtca gcacaagcga taccgcgatg tacagaaccg 706621 tacagacggc tagagctgaa ataatgccga cgggcatgtt tttttgcgga tttttcactt 706681 cctctgatgc gttagaaacc gcgtcaaacc caaggtacgc gaagaataca gtggcagcgc 706741 taagtatgac gcctttcatc ccgaatggca taaaaggaga ccagttatcc ggtttcacat 706801 agccgatgcc gacaataatg aacaataata tgatcgcgat tttcatcagt acgatgacgt 706861 tgttaaagcg tgtgctttcc ttgacgcctc tgctgacaat cgcagtgatg aggagaatga 706921 tcaccgcagc cggaaggtta aatacggcgc ccgccatgct tcccggcgct cctgtcagtg 706981 cagccggaat atgaagattg aagccggcaa gcagtgattg aaagtatgaa gaccagccgg 707041 tggcaaccgc cgacagtgca atgacatatt caagcatgag atcccatccg atcaaaaagg 707101 cgagcagctc tccaagtgtc acgtatgagt atgagtacac gcttcccgaa atcggaatgg 707161 aagacgaaaa ctcagcataa cagaaagcag ccagcgcaca ggcgagcccc gctaaaataa 707221 acgatatgat gagggcggga cctgcaccgg tcgctgccac tgttcctgta atgacaaaaa 707281 tccctgtacc gatgacacaa ccgataccga gcaaggttaa atcaaatgcg cttaacgtac 707341 gggcaaggct ttttgacttg ctctgcgcac tcaatgtttc aagcggtttt tttctaaata 707401 atgaactcat caaaagttcc tcctagaaat attcaaaata ttctaatcat tatatgcagt 707461 tcttgttgta ttatattgtc gaaatttgac gtagtcaata aaatattttt ctgctttaaa 707521 tgatagaagc gaaacagcgt tgtcgtatca taggatagta atttttacta atcgtatatt 707581 caattttatg caagatgaac cgatagaaaa aatagattcg cccatatttt gatttgcggt 707641 tataaaggag atgctgacca tgtttcaata tgaagagttg aataaacagt ttatcggcgg 707701 gaaatggcag gagggcagca gcccaaatgt attggaaaac aaaaatcctt atactcaaaa 707761 aacattcaca acattccgta aagcgactgc tgacgatgta gatgaagcgt atcgggcagc 707821 ggcgctggca aagaaaaaat gggatgcggt caacccgttc gagaaaagaa ccattttaga 707881 aaaagccgtc acgtatattg aagaaaatga agaagccatt atttatttga ttatggagga 707941 gctaggcggt acaaggctca aagcagcttt tgaaatcggt cttgtcaaaa acatcataaa 708001 agaagcggca acgttcccaa tccgcatgga ggggaaaatt cttccgtcaa caatagatgg 708061 caaggaaaac agattatatc gcgtgccggc aggcgttgtc ggtgtcatca gtccgtttaa 708121 cttcccattc tttttatcta tgaaatcagt ggcgcctgca ctcggagccg gcaatggcgt 708181 tgtgctaaag ccgcatgagg aaacgccgat ttgcggcgga acgctgattg cgaaaatttt 708241 tgagaacgcg ggaattccag cggggctgct gaatgttgtt gtcacagaca ttgctgaaat 708301 cggcgacagc ttcgttgagc atccagtgcc gcggatcatc tcatttaccg gttctacgaa 708361 agtcggcagc tacatcggac agcttgcgat gaagcatttt aaaaagccgc ttcttgagct 708421 tggcgggaac agcgccttca tcgtacttga ggatgcagat atagaatatg cggtcaatgc 708481 ggcggtgttc agccgattta cacatcaagg gcagatttgc atgtcagcca accgcgtgct 708541 tgttcattct tctatttatg acaagttcct tgagctgtac caggcaaaag tggaatcgct 708601 gaaagtcggc gacccaatgg accctgatac gattatcggg ccattaatca acagcagaca 708661 gacggacggg ctgatgaaga ctgtagagca agcaattgaa gaaggcgctg taccagtgaa 708721 gcttggcgga tttaacggga cgatcgtgga accgacgatc ttaaaagacg tcaaaccgtt 708781 catgagcatt gccaaggaag agctgttcgg accagtcgtc tcctttatga agtttgattc 708841 agaagacgaa gcggtggata tcgcaaacga aaccccgttt ggcttgagcg gtgccgtaca 708901 tacgtcaaat cttgagcgcg gcgtggcttt tgcgaaacgc attgaaacag gcatgattca 708961 cgtcaatgac acgaccatca atgatgaacc gaatgtagcc ttcggcggtg aaaagcaatc 709021 aggcctcggc cgtttaaacg gtgagtggag cctcgaagaa tttacaacgc tgaaatggat 709081 ctcggtccag cacgaaaaac gcagcttccc ttattaatga aaaggagtga atggaattga 709141 ccataaatac ggaaaaagaa accgcagata ttctggacgc atttatcaaa gtagcccctt 709201 atttaaacag cctggttcag gatgatatta caatcggcat ttatgatacg gaaaaactgc 709261 tcgtgaatat accggccaaa accttttcgc tgaacgtaaa agccggcgat ccgctgcagg 709321 aaggggatat catcacagat gccatccgca gcaatcagaa gaagacgagc atggttccga 709381 aagaattgtt cggcttccca ttgatcgcgc gtgccatccc gctgcacgac gagaatggaa 709441 gagtcattgg aggcgtcggc ctcggaacga gccttgagga gtcgtcaaag ctgcatgatg 709501 tcgcggaaag cttatcagct gttgttgaac aaacagccgc ggctatttcc gacatttctg 709561 aatcaattaa cgggttttca actcaaatgt cgggcatttc ctctcaggcg aaaaaagtaa 709621 gcgaaagcgc cggtgaaatc gccgatattt cagtaactgt taaaggcatc tcggaccaaa 709681 gcaatctgct cggcttgaac gccgcgatcg aagcggcaag agcaggggag tccggaaaag 709741 gattctctgt cgtcgcagat gagatcagaa agctagcgac gcattcaaaa gaaaatgtcg 709801 gccaaattga ccagattacg aaaaaaatcc acagcctgct gaaagggctg gaggaatcca 709861 ttgagtcgat taaccagcat acagacggac aagccgctgc tgttgaacaa atttccgcca 709921 cgatgcagga gatttcagga agcgcgcagc atcttgcgaa aatggccgaa aaagcgcttg 709981 aggaagagta agagaccggg gacaaacatc cccggtcttt ttcttatcct gcatttccat 710041 gaaattcgtc tgacgtttta ctagttttat tccagcggct gatttaaaat gtacacatga 710101 acttacgtga ggattgatag gaaccatgag catattaaaa gcggaaaatc tttataaaac 710161 atacggagat aaaacattat ttgaccatat ctcctttcat attgaagaga atgagagaat 710221 cggattaatc gggccgaacg gaacaggaaa atcaacgctg ttgaaagtga ttgccggctt 710281 ggaatctatc gaagaaggag aaatcacgaa atccggaagc gtgcaggtcg aatttcttca 710341 tcaagacccg gagctgcctg cggggcaaac agtgctggag catatctatt ccggtgaatc 710401 ggctgtgatg aaaaccttgc gtgaatatga aaaagcgctg tatgaactgg ggaaagatcc 710461 cgaaaatgaa cagcgccaga aacacctgct ggcagcacaa gcgaaaatgg acgcgaacaa 710521 tgcatgggat gcaaacacct tggcaaaaac cgtattgtct aagctgggcg tcaacgacgt 710581 aacaaaaccg gtcaatgagc tctcaggcgg ccagaaaaaa cgggtggcca ttgccaaaaa 710641 cttaattcag cccgctgatt tgctcatttt ggacgagccg acaaaccatt tggataatga 710701 aacgattgag tggcttgaag ggtatttaag ccaatatccc ggcgccgtca tgctggtgac 710761 gcacgataga tatttcttaa accgtgtcac caaccgcatt tatgagcttg aaagaggcag 710821 cctctacact tacaaaggca actatgaagt gtttttagaa aaacgcgcgg aacgggaagc 710881 gcaggctgag caaaaggaaa cgaagcggca aaacctgctg cgccgcgaac tggcttggct 710941 cagacgagga gcgaaagccc gctccacaaa acaaaaagcg agaattgacc gggtagagac 711001 gcttaaagag cagacaggcc ctcagtcatc aggttcactc gattttgcca ttggctcgca 711061 ccgtctcgga aaacaggtta ttgaagcgga gaacgtcatg atcgcttatg acggccgcat 711121 gctcgtcgac cgttttaatg aacttgtcat accaggtgaa cggatcggga tcatcgggcc 711181 gaacggcatc gggaaaacaa cgctgttaaa tgcccttgcc ggccgtcata cgccggacgg 711241 aggcgatatt acgatcggac agacggtcag aatcggctac tatactcagg atcatagtga 711301 aatgaacggt gagttaaaag tcattgacta tataaaagaa acggcggagg tcgtaaaaac 711361 ggcagatggc gatatgatta cagctgaaca aatgctcgag cgtttcctct tcccgcgttc 711421 gatgcagcag acgtatatcc gcaagctgtc cggcggggaa aaacgccgtt tatacttgct 711481 tcaggttctc atgcaggagc cgaatgtcct gtttctcgat gagccgacga acgatttgga 711541 tactgaaaca ttaagcgttc ttgaggatta tattgaccag ttcccaggcg tcgtcatcac 711601 cgtatcccat gaccgctatt tccttgaccg cgtcgtcgac cgtttgattg tatttgaagg 711661 aaatggtgtc atttcccgct ttcaaggctc ctatagcgac tatatggagg agtcaaaagc 711721 gaaaaaagcg gccccaaaac cggcagctga ggaaaaaacg gctgaagccg agccgaagaa 711781 aaaacggaaa aagctttctt acaaagacca gttggaatgg gacggcatcg aagataaaat 711841 tgcccagctg gaagaaaagc atgaacagct tgaagctgac atcgccgcag caggcagtga 711901 ttttggcaaa atccaagagc tgatggccga gcaggcgaaa acggcggaag agcttgaggc 711961 tgcgatggac cgctggacag aattgtccct catgatcgaa gaactggaaa gctaaaaagc 712021 gtggccgcag caggccgcgc tttttttcac ataatggaca aaaacgaacc ggcctgctta 712081 tgttaggata aagttgtgtg tcagcggcac atggaaaact aacggagatg atgaagtatg 712141 acatgggcga tcgtgatgtt aattctcatg agtctggtga aaatcgtatt aacctgtctt 712201 cctacaggcg tcatagaatg gctgctcggc aaatttgaag tgcacgccaa gctgagtgac 712261 gaaaatgcga gtctctctct agatggaaaa cgcctcgagg gtgcagagaa gcagaaagtg 712321 attgatcaat ttaacgaagc tatcttcctg gaaaaatatt atatctatcc aggtgatgaa 712381 gagcgttatt tacatccgga aaacggcggc acgcctctgg tgatagatac aaaaaaagga 712441 aaaaaagacg tgaagctgtt cgtgtaccgc tacgacgacc atatcgacgt cgtgaaacag 712501 tacaagaaga aagtgatcgc gtatcgagtg ctttctgaaa gccttcaaaa agagtctctg 712561 tcagtggcgg gaagtttagc ttaaacagga aagtgaaaga cgggtgctgt atgctgctcg 712621 tcttttttat tgttttttaa aacttaacgt ttacgttaag gttcaaaagg tgtataatgg 712681 taacagaaac ggcgaagggg gatttacctt ggaatggatg aagattgatc aagtggccaa 712741 aagaagcggg ctgacaaagc ggaccatccg gttttatgaa gaaatcggct tgattccggc 712801 gccgaaacgg acagacggcg gtgtaaggct ttattcagag gatgatatgg aggagcttga 712861 gaaagtcatc agcacaaaag aggtgctcgg tttttccctt caggagcttc agcatttcat 712921 ggaaaccagc cgccagctag agttaaacaa agaggggtat ttgttgtcac tggatcctaa 712981 ggaacggaaa gaaaaactgg aggaaattca ggaaaccctg aatcaccagc tggatttgat 713041 tgatgagaaa atccgcacat tccaaagctt taaagaacgc ctgcagggca tgaaaggcaa 713101 agcggaacgc gccattcaat caatcgaatg aaaagtttgt taaacgctat ttttgtagcg 713161 tttcttttaa tggaataaag atggaggtta ggtcaaatgg ataagacaac acaagtgaat 713221 cagaaaacgg gtttgctcag ccagccaaaa gcggtatggg ctgtcgcgtt tgcctgtgtg 713281 atttctttta tgggaatcgg gctggtcgat ccaattcttc cggccattgc cgcacaattg 713341 catgcttcac ctagtgaagt atcactcttg tttacaagtt atttgcttgt aaccggattt 713401 atgatgtttt tctcaggagc catttccagc cgcatcggcg cgaaatggac attaattctc 713461 ggacttattt ttattattgt gtttgcgggg cttggcggca gctcaagctc aatcgctcag 713521 ttagtcggct atcgcggcgg ctggggatta gggaatgctt tgtttatttc aacagcgctt 713581 gcggtcatcg ttggcgtgtc agtcggcggc agcgcccaag cgattatttt gtatgaggcc 713641 gcgctcggtc tcgggatttc tgtcgggccg cttgcaggcg gagagctcgg aagcatttca 713701 tggcgcgcac cgttttttgg agtatctgtc ctgatgttta ttgcgttaat cgcgatttct 713761 ttcatgcttc cgaagctgcc gaaaccggcg aaacgcgtcg gtgtgtttga tgcgatgaag 713821 gcactcaaat ataaaggcct gctgacaatg gcggtatcgg cattcctata caactttgga 713881 ttttttattt tgctagctta ttctccgttc gtactggatt tagatgaaca cggtcttgga 713941 tatgtcttct tcggctgggg ccttctgctg gcgattacgt cagtctttac ggcgccgctc 714001 gtgcacaaag cgctgggcac agtgcgttcg ctagtcgttc tctttatcgc ctttgcggcc 714061 attctcgtta ttatggggat ctggacagac catcagactt tgattattac atgtatcgtt 714121 gtcgctggtg ctgtcctcgg tatggtgaat acgatcatga caaccgctgt gatgggttct 714181 gcgccggttg aacgttcaat cgcgtcttca gcctacagct cagtccgctt catcggcggc 714241 gcgctcgccc cgtggattgc aggaatgctg tcagaacact ttactgcaag cacaccatat 714301 acagtaggcg gaatcgtcgt ttttgtcggc atgcttgtcc ttctcatggg acgtaaacat 714361 cttgctggaa ttaaggcggg gcattaataa cgaaagacac tgcgcatatg cagtgtcttt 714421 ttattcgtta taatgcatca taatcgaatt ggtgcaggaa aggacaacct ttatgacaca 714481 attttactat tttccggctg aaaactccct ttagaaaccg gttttttcgg tcagcaagaa 714541 cggcgttcgc ggaaagggca tccgcttcgg tcaggcattg atgcggctgg gatttatctt 714601 gcagaagctg agaatgtgtc cgttcattta cgattgccat ttcagtgatg gttcatgctg 714661 tagaggggac gtttgccatg gataaggcaa aacctgacga atatgatcag aaatgtttag 714721 aaacgctcta tcaatacata cacagcgtca tgaaaaacag cttttctcgg tcgagtggtt 714781 taccgcttgg gaagatgagg aggattttga gctgtctgcc aaaagagagc tgacacttga 714841 tgaattcaca tctccattgc agctcatttt aaaagacaga gagcttttga gaatcgttca 714901 gaaaaaatgg cagtaaaaaa cccgcccttt agcaggcggg tttttttata aattaaagca 714961 ctttcgtcgt ccaagactcg cagttccacg tttctgtcgc aatatccata taaaagtctg 715021 gctcgtggga aatgagcaga atggagcctt tatattcttt cagggcgcgc ttgagctctt 715081 ccttggcatc ggcatccaag tggtttgtcg gctcatcgag caccagcagg tttgtttctg 715141 agttgattag cttgcacaat ctgactttcg ctttttcgcc tccgcttaat acggagacgc 715201 ggctttcgat atgctttgtc gtcagcccgc attttgccag agcggcacgg atttcatact 715261 gcgtataaga agggaattcg ctccatactt cttcgatgca cgtattgttg tttgtttcct 715321 tgacctcttg ctcgaaatag ccggtataga tgtgctcacc gcgttcaaca gagccttcga 715381 gcggctggat ttcaccaagc aaacttttca gcaatgtcgt ttttccgatc ccattcgcgc 715441 cgtaaagggc gattttttgg ccgcgctcca tgcggaggtt gagcggacgg gacagcgggg 715501 aatcgtaacc gatcacgaga tccttcgttt caaaaatcag cttgcctgac gttctcgccg 715561 gcttaaagtg gaattccggc tttggctttt ctgccgcaag ctcgatcata tccatcttat 715621 cgagtttctt ttggcgggac atcgccatgt ttctcgtgct gacacgcgct ttgttgcggg 715681 cgacgaaatc cttcagctcc gcgacttcct gctgctgctt tttgtaggcc gcttcaagct 715741 gctgtttttt cacctcgtag acttccataa actgatggta gtcgccgaca taacgtgtca 715801 gctcttgatt ttcaacgtga taaatcaggt tgatgacact attcaagaac ggaatatcgt 715861 gggaaatcag gatgaacgcg ttctcgtatt cctgcaggta gcgtttcagc cattcaatat 715921 gctgttcatc aagatagttg gtcggctcat cgagaagcag aatttccggc ttttcaagga 715981 gaagcttagc gagaaggacc tttgtgcgct gtccgccgct caaatcggtg acatctcgct 716041 ctaaaccgat atcgctcaaa ccgagaccgc gggcgatttc ttccaccttg gaatcaatga 716101 cataaaaatc attgtttgtc agcgcgtctt gaatgacgcc gacttcttca agcagcttct 716161 cgagctcgtc gggatcagcc tcgcccattt tgttgtaaat ctcgttcatt tcctcttcca 716221 tcgcaaataa ataatggaat gcgtctttca ggacgtcgcg aatggatttt cctttttcca 716281 gcacggtatg ctgatcaagg tatccgacac ggacattttt tgaccattcg acttttccct 716341 catcaggttc aagctttccg gtaataatat tcatgaaggt tgattttcct tcaccgtttg 716401 cgccgatcaa gccgacgtgc tcgcctttta acaggcggaa ggaaacgtta ttaaaaatgg 716461 cccggtcccc gaaaccgtgg cttaaatcct ttacagataa aatactcatg tttacacctc 716521 tatcgttatc aaacacgcac aatcggcgtg taatattcac ccttttgatt ataaaggagg 716581 attcggaatg ttgaaaggta taggaaagaa aaagaaaaat tgcgttccgg gcgaggtttt 716641 gagatactat ggaatagatt tcaggaattg aggagaacaa aatgacgcaa acttggccat 716701 ttttacataa tgcacaatca tttatacaag agaattggaa tgcttccggc tttcaaaagc 716761 caacccctgt tcaggagcag gcagcccagc tgatcatgga cggaaaggat gtcattgcag 716821 aatcgccgac aggcacaggg aagacgctgg cgtatgcgct gccggtcttg gagcggatca 716881 aaccagagca aaagcatccg caggcggtga ttttagcgcc ttcccgtgag ctggtcatgc 716941 agatttttca ggtgattcag gattggaaag cgggctcaga gctgcgcgcg gcttccttaa 717001 tcggcggggc gaatgtgaag aaacaggtcg aaaagctgaa gaaacatccg catatcatcg 717061 tcggcacgcc aggcagggtg tttgaactga ttaaagcgaa gaaactcaaa atgcatgaag 717121 tgaaaacgat cgtgcttgat gaaacggatc agctcgtcct gccggagcat cgcgaaacga 717181 tgaagcaaat cattaaaaca acattaagag accgccagct tctatgtttt tctgccacgc 717241 tcaaaaagga aacagaggac gtgctccgcg aattggcgca agagcctgag gtgttgaagg 717301 tgcagcgaag caaggcggag gcagggaaag tgaagcatca atacctgatt tgcgaccagc 717361 gcgacaaagt gaagctgctg caaaagctgt caaggcttga aggcatgcag gcactcgtat 717421 ttgtgagaga cattggcaac ctgagtgtat atgcggaaaa actggcatat caccacgttg 717481 aactcggcgt tttgcacagt gaagcgaaaa aaatggagcg agcgaaaatc attgccacat 717541 tcgaagacgg agagtttcct cttttattgg cgactgacat tgccgcacgc ggtttagata 717601 ttgaaaacct gccatacgtg attcatgctg atattccaga tgaagatggc tatgtccaca 717661 gatcaggacg aacaggccgg gccggaaaag aaggcaacgt gctgagcctt gtgacaaaat 717721 tggaggaatc taagctgaaa aaaatggcga agaagcttgg tgttgagctg agtgaagctg 717781 tgtatgcagg cggaaaactg aagacgaaat aaaaagaagg gcgaagagcc ctttttttgt 717841 tgtaaaataa tagaaaagat tttgcgcgga ggtgggaaaa tggcttcaat agacaggttt 717901 caagtaatgc aggagccaga gctgaaaatc cttgaacact ggtttgagaa tgaggatacc 717961 agacggagaa tggatgggat gctgctatta gatgagtggt atgcacgagt aaataaagat 718021 aaacacgata ctgtcatcat ggcgtatgat ggacagctgc cggcagggat ggtcgttatt 718081 gagttcggag aggagcggac atatattgga ttgatcgtca atcctttgta ccggcttaaa 718141 gggtatggaa aacagatact gcaaaagctg atgaccgaac ctgattttac tagcgtgcga 718201 gaatgggtgg catgcattga agaagacaat cgaatcagtt tagcttgctt tcaagcagca 718261 ggattcactt tagaagacac ggaacctgat gaagatggtt ttcttacgct gattcttcgc 718321 aactgatctc atcgaaacac aaaaggaggg caaaaagccc tcccgttttc atcttcattc 718381 agctcggatc actgaccttg atcagctgtt tccctttatt ttctccctta aataaaccga 718441 gaaacgcgtc aggaatgttt tcgaagcctt ctgtgatggt ttcctcgtaa tggagtttac 718501 cagccttcag ccattctgcc agctgttttg ctccctcaga aaaacgatcg gagtagtcgc 718561 ttacgataaa gccttgcatc agcgacttcg ttttaatgag ttttgattgg acacgagggc 718621 ccatgtcatc tgcttcgctt tctgcgttat aggaagaaat ggcgccgcac accggaatgc 718681 gggcaaattc attgagcaga ttcatcaccg cgtctgaaat cggtccgccg acattgtcaa 718741 aatacacatc gacaccgtca ggacaagcgt tttgaagcgc tttttggata tcatccgctg 718801 ttttgtaatt gatggcttcg tcaaactgaa gctcctgttt taaatagtcg attttttcat 718861 cagagcccgc gatgccgacg actcgcgcgc ctttgatttt ggcaatttgc ccgactgttg 718921 aaccgacggc tccggcagct cctgagacaa ccacggtttc gccttccttc gggcgtccga 718981 tgtccagcaa tccgaagtat gctgttaagc cggtcattcc caaaatgccg agataggccg 719041 aagcgggagc aaggcttgta tcaatttttc gcaaggcaga ctcgctcaca gcggaaaatt 719101 cctgccagct gagatttccg atgacgatat cgcctttttt cagatgattc ccgtctgaca 719161 caacttcagc gataacccct ccagaaagcg ctttatccaa ggcgaacggc tcaacatatg 719221 acttcgtatc ctgcatacgg ccgcgcatat aagggtcaac cgatacataa agcgttttga 719281 caagcacttc cccttgcttg ggttcaggaa ccggaatggt ttcaaagcga aagtcttcat 719341 gaacaggaat accttgtgga cgtcttgcta attgaatttg ctgctgagat gctgtcattt 719401 tcatcctcct atcacttggt tgacaccact gtaacatgga caggagagga aatacaaaag 719461 gtaagctggc atacaaaaaa ggttatagat gagcttatgc tttctacaag ctcttttgtt 719521 ttaaaagttc tctttagtca tttatcatta ttagaaaaca gaacagaaaa agagctcctg 719581 tacacctagc taagattggc tagtgtgtat gtcgattctt tttcatattc ttgcaagcat 719641 ctgcgagggg gagcttagtc gttcacattt tgctttcgca tcaatctgca atagcaaagt 719701 ctatgcgatt tttttacatc agcaaagatt tgttcaattt tttcctttta tgccgagttt 719761 ttctgaaaca gataattgat ggtactcaac cattttcttt tggtcaataa agtaatgttt 719821 acttattaat taaacacgcg aaaaagcaaa cgaaaacata attaaatttt atatatttat 719881 taaaagctta tatgtttatt tacctttttt ttgaattgta attgagaaaa tccatatatt 719941 gcggacacta ataaaagaat acctgctgaa acataaacta aacgaactcc aaggaaatct 720001 gaaatagccc ctatagccag aattgaaaac ataaaaatga actgtactaa agaagacctt 720061 gcagacatta tattaattcg agtttgctcg gttgttatgt tctgaataag tgtttcttgt 720121 gtaagatctc ttaatatata agccggcccc ataaagagaa ccaaaattag agctaagtat 720181 gaattactta taaaaccata tattaaagtt aaacttccat atgagacagc gccaattaac 720241 ataaaattaa ttaacttatt ttgaaatctc tccgacagct tatatattat aaatccccct 720301 atcatcgaac ctaaataata tgctccatta ataaatcccc accatgattc tcctttatgc 720361 aagacttcgt taacgaaagc taaagagaca gatcctatcc aaatcattcc tgcccatgac 720421 tcaattaaat ccataataat aattgttcta agtttctttt ggctaaataa ataccgccaa 720481 ccacttacta tactcttatt gggagaattt ttttcacgta tgacagaatt agcgtggcca 720541 tgtggtagac aaaataaaag agaaagaaga gatgtaaaca acaaaaagat agtaagtata 720601 atggtatatc cctcacctaa aaatgcaatt atgagaccac ctaaagacca gcctacaaat 720661 tgaaaagttt ggtccactgt agataataat ccatttgctt ttactcttct atcaggagag 720721 attatttccc ctataattgc actttttaaa ggtgagaacc atccattaaa aaaggaaata 720781 cagctaataa taataaagac taaaatgaga gtttgattag agtaagttct taataaagca 720841 tagaacaaac atattaataa cagcatttgt atcaattgag aaataattat tgtaagaggc 720901 agttttaatc gaattgttat taacggtaat atagcacttc caaaaatacg aaaaataata 720961 cttattaatg tcaccataga ggcgatggtt gtcgaattgg tcattttaaa caaaaacgaa 721021 atcactacca tagtatatag agaaaaacct aaatttgtag tggtctggct aaataaaata 721081 gaataataac ctttactcat atgtatcctc ccttggaata atttttctcg gtaaagagct 721141 taaacatatt taaacacctt aaaacaacaa aagtaaagaa aaaatttcct tgtaaactat 721201 ttacttttat tctatttatt gttattgttt atttaagttc tctgactatt ctatcaatat 721261 tcagggaacc acatatctta ttaaaggggg gaaaaccatg agaaaattaa gaaaaaactg 721321 gagaaaatcg attgttagcc cggttcttta tactaatgaa aaatggtaaa cacttaggga 721381 atagcattta atgctattcc ttatttcaac aaacaaatcg ggaggttatc gtaatttgac 721441 tctattaatg caagatcata aatcaattta caataaagat atagaaatat taattgaagt 721501 tgaagaactt attacttctg ttccagaaaa taaaaaaaat gattttaaga gtttaatcga 721561 taatagaatt atgactctac taaataaaat tcaacaccct gtagcagcgg aaaatgtgtt 721621 tgggatgtgt attgcttatc cgaatactta cataaggtat agattaattg atttcgttga 721681 aaaatgggta ccttatttct ctgctgtaga aactataatc aatctaaccc aggatccgga 721741 tgatttagtt tcttttaaag ctatggatgt ctgtgcaaat cataaaattg aagaatctgt 721801 agcatatttg tcttcgatta ttgatgatgt ccgggagagt ataagctacc ctaaaaaacc 721861 tgtgggatta ggggcccaaa aagtattaag tacattatta gatatattcg gtgttgaaaa 721921 acatgaagag ctagtaatgc taaaaaatta ttttgatcaa aatggtatac ttcctaataa 721981 ctttgacttt gaagaaaaaa ttcctcaaag tctaatagag gaattcgaaa aaacagaaga 722041 agatgggatg attttaattc cgggtggctt ttttgaattc ggtttaaatg aaaatgaaat 722101 tcctgacaaa acatttaatt ggaaagatgc tgttcctaga caaaaagtat ggttacctcc 722161 attttttatc gataagtatc ctgttacaaa taaagattat gatatcttta ccgagttcat 722221 agaggaaaat gggcatatat tctgtcatcc taatgaaccg cagaataaac aacatagaag 722281 aaatacatat tgggatgata ggtatttaga taatcatccc gttacaggta tagattttta 722341 tgatgcattt gcttacgcaa gatataaggg gaaagaattg ccaaccgagt ttcaatggga 722401 aaaagctgct cgaggcgaaa agggtaatgt ctggccttgg ggagataaat ttgatcctgc 722461 aaaggttcaa tatgctggaa gtctttataa tgaacccatt acttctttaa agtcctggag 722521 agaaaattta ttaaaagctc atgctgataa agaattaaat catttaacaa gtgatatttt 722581 tgaacaaaat ggtgaaagtc cctatggagt atgcggtatg atcggcggaa catgggagtg 722641 gactagaagt gagcttaaaa caaagagagc tttccaccct atttttgaga atgtaccatt 722701 taatagtgtt aactcatttg ccgttcttaa aggaggatca ttcttctctc atccaggctt 722761 aatgttccct tcttttagag caaaagatat tcctttctgt cgacacaatg aaatggggat 722821 tagatgcgta aagaatattc cagtatataa aattagagaa tcaattaatg ggccaattac 722881 taataaagca atttattaat cattctaggt tagagacttg ataaaagtat actaacattg 722941 tgtagtaatg ttcagcttgt agaaaaaaca atgttttttc tacaagattt tattttaaat 723001 gcttttcaaa attatcaggg attgagaatc agaaaaagag ccattaagct cgatcttagc 723061 taggtattac gatcttctgt atattattgt gagaaatata gaagattcag ttagttagca 723121 tttcgatttt aagctgagcc tgcaatagca aagcatctgt tttgattatt ctttttctga 723181 tacataagct aattttgtcg cttttctttt ttgtcttttc acgcatttcg aggatgactt 723241 actataattc tttcagcttt tctatgtgtt aagattcgaa tagatgaaat aactttaaca 723301 agttggtcaa taagaacaga tttaacttta tgttaaaaga gtatctcgta tagaacataa 723361 gaagaatgac gagtttttta agattatcat caattatgtg agaataaaat attataaggg 723421 aaaatgaagg ctgtcacgtt tctcgacagc cctagggaat tcctctcctt ttcatttcgc 723481 ccgtaatttc gggcacagtc ccgtcggcag gcacattggc ttctggtcga tcgggcttct 723541 catgatgcag cattccaagc cgaagacttc acggaaaaat ggctgggtga acacatcttc 723601 cggtgttccg gcgttgtata tttttccgtc cagcacactg atcagatagt cagcatattg 723661 agcggcttgg tttaaatcat ggagcaccat gacaacggtg cggccatggt cgcggttcag 723721 ctttttcagc agttcaagca cttcaatctg atgtgagatg tctaaatacg tggtcggctc 723781 atcaagcaaa agcaaatcag tgccttgcgc aagtgccatg gaaatccagg ctctttgtct 723841 ttggccgcct gagagggcat caagtgtccg atccttcagt tcaatcatgc ccgttgcttc 723901 cagcgcccac tctaccatgt catgatcctc ttgggtatgc ttggataaca gctttttgtg 723961 aggatgtctg ccaaaatagc ataattcctc taccgtcaat ccttcaggag cctgaggaga 724021 ttgtggaaga atggccagtt tttttgcgac ttcttttgat ggctggcggt ggatgtcttt 724081 tccttctagt agcactgtac cgctttttgg ggccatcagc ctggcgagcg atttgaggat 724141 tgttgattta ccgcagccat tagcgccgat gagcgcagtg atttttcctt cttctatctt 724201 taagtcgact ccgtcaataa tcactgtact gtcatatgaa agagtgagct ggtctgcagc 724261 cagttttccc atggtatcct ctccctactg tttcctcgct tcgaatttca ataaatataa 724321 gaaataaggc gcgccgatca cggctgtcag tattccggca ggtatttcaa ccggaggcat 724381 gatgccgcgc cctaacgtat ctgcaattaa taatataata gcaccaatca atgccgatgc 724441 aggcagtaaa tatttagctt tttctccggt aagccgtctg gcgatatgcg gagcaagcaa 724501 gccgataaaa ccgattgagc cgacgacggc tacacagctt cccgccagcg ccaccgcggt 724561 gaaaatcagg atgaatctca gccggtttgc gttttctccg agaccctgtg caagctcatc 724621 cccgagtgac ataagatcca gcttcggtat gagtatgcag acgatcggaa aaagaatcaa 724681 aagccatggc gcaagcagct tgacttcttc ccagtttctt ccccagaggc ttcctgtcag 724741 ccaaatgagt gcagcattca cgtcgcctgg aaacttgacc atcatatatt gcattccggc 724801 gtggcagacc gcgcctaaag caatgcctga taaagccagt gaagagggct gaatgctctt 724861 ttttcgggct atcattaata atagtacagc aataatggcg gctccggcaa atgcggagaa 724921 cggaagcacg tataccggcg actcaggaaa gatgagaatc acagccatcg ccgcaagtcc 724981 ggagcctttt gaaatgccga caacgtccgg ggaagcgagc ggatttcgga tcacaccctg 725041 taaaatcgct ccggcagcgg caagtccagc acctgccaaa atcgctaata taatgcgggg 725101 aaggcgatat tgctggatga taaattcaaa ggaatgatcc agtcccagca gattcgtcac 725161 taccgcatca ggtgaaatgt ataatgcacc gattccaatg ctgatgacgg acagaacgat 725221 taaaatcacg gccaatatga gtatcgccag taaggggcgt ttttgttttc tggttgtttt 725281 cttcatttca ggtttcgccc tttccttgcc aaatataaga aaaacggcgt tccgataatc 725341 gcggtgacaa tgccgaccgg tgattcataa ggaaatgcaa tccatctggc cagaacatct 725401 gcgtacacca gcaaaatggc accgaacagt gccgaaaacg gaagcacgta ttgataatgt 725461 tctccgatca gcttgcggac aatatgcggg acgagcagcc cgacaaagcc aatcggcccg 725521 gcgacggcta cggaagcgcc ggaaagaatt aaaataatca aactgatcag aatcctgatg 725581 ccgttcatat tttgtccaag cccttttgct gtttcgtctc cgagaccgag aacagaaaca 725641 gaaccggaaa atacgagggc aagcccgatg ccaatgacag aaaaaggagc gatggttatg 725701 acgtcctgcc agttgctgcc gtcgattgcg cctgtcatcc agtacagaac atcctcacct 725761 gactcattta aaataatgat ggcctgtgtc atagaggaga ggaacaagtg cacggccatt 725821 cctgacagcg ccagcttgac aggcgtcatt ccgccggatg aggcaatcat atacacaatc 725881 gcgccgcctg ctgccgcacc cgcaaaagcg aatataacag atgaataggg cgatgccggc 725941 agaatgacga gagaagcaac aacaaaaagc gatgcacccg cattcacacc gaaaatttgg 726001 ggtgaagcca gaggatttct ggtcatagcc tgcatcagcg cccctgctac agctaggctg 726061 gcgccgacaa aaacgccgat taatgtgcgg ggaaggcgaa gagtagagat gatgagctgt 726121 tcctttgaac cgtcccatac aaaaagatat ttcaatgaat ctatgatgct gatgtctgag 726181 gctcctactg aaagattcag cccaagccca aatataaaaa taatcagtgc aatgataaac 726241 atcatcagtc ttgatgatga gcgccgtttg gctgaatgat acaacagtct cacttcctta 726301 ctgcgtctgg ttgcaaaaac gaagaagcaa ggattcccct cgcttctcat ttgtcctatt 726361 tattatacac ttttttaagc acatctttgg cgcttgtttc actagacttg atgcctctga 726421 atcttgtcca agtgtcacgg tccgcatcat agacttgtcc atttttcacc gctttgagat 726481 ttttccagag cgggttcgtt ttccactcat ctacaatggt tttgccttcg ttggctgaga 726541 tgaacaaaat atcaggatcg attttgctca attgctcaag gctgacctct tgataggcgt 726601 tatctgactt cacagcgtgt gtaaagccta gcattttaaa gatttctccg tcataggatg 726661 atgatgtatg aagctggaag gaatccgctc ttgcaacgcc gagaacgatg ttgcggtttt 726721 catctttcgg aagttcggct tttagatcgt tgatgacttt tttgtgctcg gcaagctttt 726781 cttttccttc atcttcttta tttaatgctt tagcaatggt cgtaaagctg tcgatcgttt 726841 cgtcatatgt cgcttcacgg ctttttaatt caatcgtcgg ggcgattttt ttcagctgtt 726901 tataaatgtt tttatggcgc tcagcgtcag cgatgattaa atcaggcttc aaggaactga 726961 tgacctcaag attgggttcg ctgcgtgtgc ctacagatgt gtaatcaatg gagctgccga 727021 caagcttttt aatcatatct tttttgttgt catctgcgat gcccaccggc gtaatgccga 727081 gattgtgaac ggcatccaag aatgaaagct caagcacaac cacccgctta ggtgtgccgc 727141 ttactgtcgt ttttccttct tcgtcatgga tcactctgga atccttagac tcgcttttgc 727201 cgcttccgtt gttattctgg cttgatgaac agccggatac aatgaggcag gcgagcaata 727261 aaacactcat gatggcaatc aacttgttag aataggtgcg catgtcattc ttcctttttt 727321 cagatttagt aatgagaatc attatcacat gtaacactat aatagcatgg cttatcatgt 727381 caatattttt ttagtaaaga aagctgcgtt tttactgctt tctcatgaaa gcatcatcag 727441 acacaaataa gtggtatgca gcgttaccgt gtcttcgaga caaaaacgca tgggcgttgg 727501 ctttagaggt ttcgaacata tcagcagtga cataaggaag gagagtgctg agataaccgg 727561 acaatttctt ttctatttca tctgttagtg caaattcaat gtcgccgata ttcatgataa 727621 tcgagaaaac aaagtcgata tcgatatgaa aatgttcctc ggcaaaaacc gcaagctcgt 727681 gaattcctgg tgaacatccg gcacgcttat ggaaaatctg tttgactaaa tcactcacaa 727741 tccaagcatt gtattgctgt tctggtgaaa agtattgcat tagacatacc tcctgctcgt 727801 acggataaag gcagcgtttc atggtcgtgt gctccgtgca gcggcttctc cttaattttg 727861 atttttctga aaataggtcc cgttcctatc actttaccat ggacggaaaa caaatagcta 727921 ctaccattcc tcctgttttt ctcttcaatg ttctggaatc tgtttcaggt acagacgatc 727981 gggtatgaaa gaaatataga aaacatgaag gaggaatatc gacatgaaac cagttgtaaa 728041 agagtataca aatgacgaac agctcatgaa agatgtagag gaattgcaga aaatgggtgt 728101 tgcgaaagag gatgtatacg tcttagctca cgacgatgac agaacggaac gcctggctga 728161 caacacgaac gccaacacga tcggagccaa agaaacaggt ttcaagcacg cggtgggaaa 728221 tatcttcaat aaaaaaggag acgagctccg caataaaatt cacgaaatcg gtttttctga 728281 agatgaagcc gctcaatttg aaaaacgctt agatgaagga aaagtgcttc tctttgtgac 728341 agataacgaa aaagtgaaag cttgggcata aagcaaggaa aaaaccaaaa ggccaatgtc 728401 ggccttttgg tttttttgcg gtctttgcgg tgggattttg cagaatgccg caataggata 728461 gcggaacatt ttcggttctg aatgtccctc aatttgctat tatatttttg tgataaattg 728521 gaataaaatc tcacaaaata gaaaatgggg gtacatagtg gatgaaaaaa gtgatgttag 728581 ctacggcttt gtttttagga ttgactccag ctggcgcgaa cgcagctgat ttaggccacc 728641 agacgttggg atccaatgat ggctggggcg cgtactcgac cggcacgaca ggcggatcaa 728701 aagcatcctc ctcaaatgtg tataccgtca gcaacagaaa ccagcttgtc tcggcattag 728761 ggaaggaaac gaacacaacg ccaaaaatca tttatatcaa gggaacgatt gacatgaacg 728821 tggatgacaa tctgaagccg cttggcctaa atgactataa agatccggag tatgatttgg 728881 acaaatattt gaaagcctat gatcctagca catggggcaa aaaagagccg tcgggaacac 728941 aagaagaagc gagagcacgc tctcagaaaa accaaaaagc acgggtcatg gtggatatcc 729001 ctgcaaacac gacgatcgtc ggttcaggga ctaacgctaa agtcgtggga ggaaacttcc 729061 aaatcaagag tgataacgtc attattcgca acattgaatt ccaggatgcc tatgactatt 729121 ttccgcaatg ggatccgact gacggaagct cagggaactg gaactcacaa tacgacaaca 729181 tcacgataaa cggcggcaca cacatctgga ttgatcactg tacatttaat gacggttcgc 729241 gtccggacag cacatcaccg aaatattatg gaagaaaata tcagcaccat gacggccaaa 729301 cggatgcttc caacggtgct aactatatca cgatgtccta caactattat cacgatcatg 729361 ataaaagctc cattttcgga tcaagtgaca gcaaaacctc cgatgacggc aaattaaaaa 729421 ttacgctgca tcataaccgc tataaaaata ttgtccagcg cgcgccgaga gtccgcttcg 729481 ggcaagtgca cgtatacaac aactattatg aaggaagcac aagctcttca agttatcctt 729541 ttagctatgc atggggaatc ggaaagtcat ctaaaatcta tgcccaaaac aatgtcattg 729601 acgtaccggg actgtcagct gctaaaacga tcagcgtatt cagcggggga acggctttat 729661 atgactccgg cacgttgctg aacggcacac agatcaacgc atcggctgca aacgggctga 729721 gctcttctgt cggctggacg ccgtctctgc atggatcgat tgatgcttct gctaatgtga 729781 aatcaaatgt tataaatcaa gcgggtgcgg gtaaattaaa ttaagaaagt gaaaaacaca 729841 aagggtgcta acctttgtgt tttttaatta attaaaatgt ttattaactt agttaaggag 729901 tagaatggaa aaggggatcg gaaaacaagt atataggagg agacctattt atggcttcag 729961 aaaaagacgc aggaaaacag tcagcagtaa agcttgttcc attgcttatt actgtcgctg 730021 tgggactaat catctggttt attcccgctc cgtccggact tgaacctaaa gcttggcatt 730081 tgtttgcgat ttttgtcgca acaattatcg gctttatctc caagcccttg ccaatgggtg 730141 caattgcaat ttttgcattg gcggttactg cactaactgg aacactatca attgaggata 730201 cattaagcgg attcgggaat aagaccattt ggcttatcgt tatcgcattc tttatttccc 730261 ggggatttat caaaaccggt ctcggtgcga gaatttcgta tgtattcgtt cagaaattcg 730321 gaaaaaaaac ccttggactt tcttattcac tgctattcag tgatttaata ctttcacctg 730381 ctattccaag taatacggcg cgtgcaggag gcattatatt tcctattatc agatcattat 730441 ccgaaacatt cggatcaagc ccggcaaatg gaacagagag aaaaatcggt gcattcttat 730501 taaaaaccgg ttttcagggg aatctgatca catctgctat gttcctgaca gcgatggcgg 730561 cgaacccgct gattgccaag ctggcccatg atgtcgcagg ggtggactta acatggacaa 730621 gctgggcaat tgccgcgatt gtaccgggac ttgtaagctt aatcatcacg ccgcttgtga 730681 tttacaaact gtatccgccg gaaatcaaag aaacaccgga tgcggcgaaa atcgcaacag 730741 aaaaactgaa agaaatggga ccgttcaaaa aatcggagct ttccatggtt atcgtgtttc 730801 ttttggtgct tgtgctgtgg atttttggcg gcagcttcaa catcgacgct accacaaccg 730861 cattgatcgg tttggccgtt ctcttattat cacaagttct gacttgggat gatatcaaga 730921 aagaacaggg cgcttgggat acgctcactt ggtttgcggc gcttgtcatg ctcgccaact 730981 tcttgaatga attaggcatg gtgtcttggt tcagtaatgc catgaaatca tccgtatcag 731041 ggttctcttg gattgtggca ttcatcattt taattgttgt gtattattac tctcactatt 731101 tctttgcaag tgcgacagcc cacatcagtg cgatgtattc agcatttttg gctgtcgtcg 731161 tggcagcggg cgcaccgccg cttttagcag cgctgagcct cgcgttcatc agcaacctgt 731221 tcgggtcaac gactcactac ggttctggag cggctccggt cttcttcgga gcaggctaca 731281 tcccgcaagg caaatggtgg tccatcggat ttatcctgtc gattgttcat atcatcgtat 731341 ggcttgtgat cggcggatta tggtggaaag tactaggaat atggtagaaa gaaaaaggca 731401 gacgcggtct gccttttttt attttcactc cttcgtaaga aaatggattt tgaaaaatga 731461 gaaaattccc tgtgaaaaat ggtatgatct aggtagaaag gacggctggt gctgtggtga 731521 aaaagcggtt ccatttttcc ctgcaaacaa aaataatggg gctgattgcg gctctgctgg 731581 tctttgtcat tggtgtgctg accattacgt tagccgttca gcatacacag ggagaacgga 731641 gacaggcaga gcagctggcg gttcaaacgg cgagaaccat ttcctatatg ccgccggtta 731701 aagagctcat tgagagaaaa gacggacatg cggctcagac gcaagaggtc attgaacaaa 731761 tgaaagaaca gactggtgcg tttgccattt atgttttgaa cgaaaaagga gacattcgca 731821 gcgcctctgg aaaaagcgga ttaaagaaac tggagcgcag cagagaaatt ttgtttggcg 731881 gttcgcatgt ttctgaaaca aaagcggatg gacgaagagt gatcagaggg agcgcgccga 731941 ttataaaaga acagaaggga tacagccaag tgatcggcag cgtgtctgtt gattttctgc 732001 aaacggagac agagcaaagc atcaaaaagc atttgagaaa tttgagtgtg attgctgtgc 732061 ttgtactgct gctcggattt attggcgccg ccgtgctggc gaaaagcatc agaaaggata 732121 cgctcgggct tgaaccgcat gagatcgcgg ctctatatcg tgagaggaac gcaatgcttt 732181 tcgcgattcg agaagggatt attgccacca atcgtgaagg cgtcgtcacc atgatgaacg 732241 tatcggcggc cgagatgctg aagctgcccg agcctgtgat ccatcttcct atagatgacg 732301 tcatgccggg agcagggctg atgtctgtgc ttgaaaaagg agaaatgctg ccgaaccagg 732361 aagtaagcgt caacgatcaa gtgtttatta tcaatacgaa agtgatgaat caaggcgggc 732421 aggcgtatgg gattgtcgtc agcttcaggg agaaaacaga gctgaagaag ctgatcgaca 732481 cattgacaga ggttcgcaaa tattcagagg atctcagggc gcagactcat gaattttcaa 732541 ataagcttta tgcgatttta gggctgcttg agcttgggga gtatgatgaa gccattgatc 732601 tgattaaaga ggaatatgcg atacaaaatg aacagcatga tcttttattc cataacatcc 732661 attcgcagca ggtgcaggcc attttgttag ggaaaataag caaggcatcg gaaaagaagg 732721 tcaagctggt gattgatgag aacagctcac tcgcgcctct tcctgcgcat atcggcttgt 732781 cccatcttat tacgattatt ggcaatttaa ttgataacgc tttcgaagct gtagcggagc 732841 aaagcgtgaa ggaagttttg ttttttatca cggatatggg ccatgacatt gtcattgaag 732901 tatcagacac agggcccggt gtgccgccag agaaaataga agctgtgttt gagagaggct 732961 attcttcaaa ggggatgagg agaggctacg gtctggccaa tgtgaaagac tcagtgcgtg 733021 aactgggcgg ctggatcgaa ctggcgaatc aaaaaactgg cggggcggta ttcactgtat 733081 ttataccgaa ggagaaacaa agggggaatc catttgattc acatcgcgat tgcggaggat 733141 gattttcgag ttgcgcaaat ccatgagaga ttgattaaac agcttgatgg attcaagatt 733201 atcggcaagg cggctaacgc aaaagagaca ttggcgcttt tgaaggaaca caaggctgat 733261 ttgcttctgc tggatattta tatgccggac gagcttggga ccgcgttgat tcctgatata 733321 cgaagccgat ttcctgaagt ggacattatg attatcacag cggcaacaga aacccgtcat 733381 ttgcaggaag cgctaagggc gggaattgcc cactatttga tcaaacccgt aacagctgac 733441 aagttcaggc aggtgctgct tcagtataaa gaaaaaagga agctgctcat gtctcagccg 733501 gaggtcagcc aatccatgat cgaccatatt tttgggaacg gtgtgaagac agctttgccg 733561 gcagaggatt tgccgactgg cattaattcg attacactgc gaaaaattaa ggaagcgctt 733621 cagactgcgt cagaaggatt gacagcggag gaacttgggg aaaaaatggg ggcgtcacga 733681 acaactgccc gccgttatgc cgagtacctt gtgtcaaagg aagaagcaag agccgagctt 733741 gaatacggga ttatcggcag gccggagaga aaatattatt tggcggcgga ttagatatga 733801 aaaaatctat aatcctattg aatattctat tgatctttat gcagggtgat atcaggcagg 733861 cggctgcgcc gcgcctgccg gacgggccga tagaaattgt cgtccctgcc gaaccttctg 733921 gcggctggga tgtcacagcg caggcgatcc aatcagtttt gaggcagaag cagatcgtga 733981 aggatgatgt tcatatcgtc tataaatccg gcggcggggg agagaaaggc tggaaatatg 734041 tcaacaaaag cagcaaacaa accatcagca tgacgtccag cctaatattg agcaatgatc 734101 ttctcgggca aagcaaatta aaaatgtccg attttacgcc gctcgccatt ctctccaagg 734161 aatggcagac ggttgcattg ccaaaaggat cagcgttaac aaatggcaag gatgtgctga 734221 atgagatcaa catgcatccc ggcaaggtga gaatcggctt tgccccgggg tttggcaatg 734281 atgatcagct ctcgttcgtc agagcggcag atatgtacgg cattgacccg tttgacattc 734341 aattctcaca gtatgacagc agcgaacagc tcattcaggc gctgatcaga catgagatag 734401 aagcggcttc catgacactt tctgaagcga aaccatatga acgaaacggc gatatcacgt 734461 tagccgctgt aacgtctgat aaaagacttc ccggttttcc aaatgtaccg acgtggaagg 734521 agcagggaat cccgtttgtt ttttctcatt ggagagggat tttgggcccg aaaaatatgt 734581 ctgaggaaga gatttcttac tgggatcaag cgctaaagaa ggtcacctcc tcacctgaat 734641 ggaagcggaa aataaacgaa caggactggg aaagctttta tttaaacagc agggaaacga 734701 aacggttttt agaagagcaa tctgcttttt atcaaagcat catgacagga aattaaaatc 734761 ccgacatccc gggatttttt tcatgccgaa aattgatcaa aaagaacaaa acggttttaa 734821 aaaattaaaa atacaaaaaa accaaattat ttacttgcgg ttggttttcc catacgatgg 734881 caaaaaggca agacaaaaag gggagtaagg gagaaaaaaa tgtaagcgga ttcatttaag 734941 ggggaatgga tgtgttagca atcttaggct ttctcatgat gcttgtgttt atggcattga 735001 tcatgacaaa acggctttct gttttaacag cattagtttt gacgccgatt gtgtttgcgc 735061 ttatcgccgg atttggattt actgaagttg gggacatgat gatttcgggg attcagcaag 735121 tcgcgccgac tgcggtcatg attatgtttg cgatcttata ttttggaatt atgattgata 735181 caggcctgtt tgatccaatg gttggcaaaa ttttaagcat ggtcaaagga gaccctttaa 735241 aaattgttgt cgggacagcg gttcttacaa tgctcgtcgc cttggacgga gatggctcga 735301 caacgtacat gattacgaca agcgccatgc ttccgctcta tttgctgcta ggcatccggc 735361 caattatctt ggcaggaatc gcgggagtcg gcatgggaat catgaacacg attccatggg 735421 gaggtgcgac gccgagggcg gcgagtgcgc tgggggttga tccagctgag cttacagggc 735481 cgatgattcc tgtcattgca agcgggatgc tttgtatggt ggcagttgcg tatgtgcttg 735541 gaaaagcgga acgaaagcgc cttggtgtga ttgaactgaa acagccagcc aatgccaatg 735601 aaccggctgc tgcggttgaa gatgagtgga agcggccgaa gctttggtgg ttcaatttat 735661 tgttaacgct ttctttaata ggatgtttag tatcgggtaa agtcagttta accgtactgt 735721 ttgtcattgc gttttgtatt gcgctgattg tgaattatcc caatctcgag catcagagac 735781 agcgcatcgc ggcgcattcc agcaacgtgc tggctatcgg ttcaatgatt tttgctgcgg 735841 gggtgttcac ggggattttg acaggcacga aaatggttga tgaaatggcg atctcgctcg 735901 tgtccatgat accggaacaa atgggcggat tgatcccggc gattgttgcc ttaacaagcg 735961 gcattttcac atttttgatg ccgaatgacg cgtatttcta cggggtgctg ccgattttat 736021 cagaaacagc tgtcgcatac ggtgtggata aagtggaaat tgccagagcc tctattatcg 736081 gccagccgat tcatatgctg agtccgcttg tgccatccac tcatttgctt gtcggactcg 736141 tcggagtttc tattgatgac catcaaaaat tcgcattgaa atgggcggtt ctcgcagtga 736201 tcgtcatgac ggctatcgct ctattgatcg gtgcgatctc tatttccgta tgataattca 736261 ggcgtaatga cacacactaa cggcatacaa cattccggag gtgtcattat gagtgatcct 736321 tatatgccgc tgacttcagt cagaagcgga gcggggttcg aagcggcaaa aggggtgcac 736381 ggcctgactg tgcaaattgc gaatgtctat tttattcagc tgccttctga acctcactca 736441 tttgttttaa ttgatgccgg catgccccaa tcagccggcg tgattgtcaa tgaagccaaa 736501 caaagattcg gtgaagggtt tcagctgaag gcgattatcc tcacacacgg gcactttgac 736561 catattgggg caatcgaaga gatccttgag cattgggatg tgcctgttta tatccattct 736621 cgggaaatgc cttatgtaac aggtaaagag gattatcctc cggctcgtcc tgacagcaag 736681 agcgggctgg tcgctaagct gtcgccgctg tttccgcggc actctatcga tatttcctca 736741 catgtccagg cactgccgga agacggttca gttccttttc ttgacgagtg gatgtggatc 736801 gcgacaccag gacacacgcc gggccatatt tcgttattcc gcgatgacgg ccgcgtgctt 736861 gtggcaggtg atgctgttat tacagtggaa caggagaaaa tggctgacgt cttgatacaa 736921 aaacaggagc ttcacgggcc gccggcttat ttcacgcctg acacagagac ggccgctgag 736981 tccattctaa agctggccgg tcttgaaccg gaagcgttat tgaccgggca cggcataccg 737041 atgaccggca aaaactttcg aagtgactta actgaattgg caaatcggtt atcgtctatt 737101 tgacacccgc accacgcggg tgttttttat tgttttccag gaagttgcag aaaaatcatt 737161 tgtcttgccg cttaaaaacg atacaatgaa aagcatgaag tgatgtgaag gggagagttt 737221 gttggaagaa aaagaaatac tctggaacga agcgaaagcg tttattgccg catgctatca 737281 ggaattggga aaggaggagg aagtgaaaga ccgtctcgcg gacattaaaa gtgaaattga 737341 cctgaccgga agctatgtac atacgaagga agagctggag cacggagcga aaatggcttg 737401 gagaaacagc aaccgctgca tcggcagatt gttctggaat tcgctgaatg ttatcgacag 737461 acgagacgtc cggacgaagg aggaagtgcg tgatgccctc tttcaccata ttgaaaccgc 737521 caccaataac gggaaaatca gaccgaccat tacgattttc cctccggaag agaagggtga 737581 aaagcaagtc gagatctgga atcatcagct gatccggtac gctggatatg agtcagacgg 737641 agaaagaatc ggcgacccgg cttcctgttc cctgacagca gcctgcgaag agctcggctg 737701 gcgcggagag cgaacggatt ttgacctgct gccgctcatt tttcgcatga aaggggacga 737761 gcagcctgtc tggtatgagc tgccgcgttc acttgtgatt gaggttccaa tcacacatcc 737821 ggacatcgag gcgttttctg atttggagct gaagtggtac ggcgtgccta ttatttctga 737881 tatgaagctt gaggtcgggg gcattcatta taatgccgcg ccatttaacg gctggtatat 737941 gggcacggag atcggagcga gaaacctcgc agatgaaaag cggtacgaca agctcaaaaa 738001 agtagcgtcc gtgatcggca tcgccgctga ttacaatacg gatttatgga aggatcaagc 738061 gctagttgaa ttgaataaag ctgtgctgca ctcgtataaa aagcagggtg tcagcatcgt 738121 tgaccatcat acagcggcaa gccagtttaa acggtttgaa gaacaggagg aagaagcggg 738181 cagaaagctg acgggggact ggacgtggct gattccgcca atttcacccg ctgccactca 738241 tatcttccac cgctcctatg ataactcaat cgttaagccg aactattttt atcaagataa 738301 gccttatgag taaacaatag aaaatcgatg atggccttca aggctgcggg attcagtcac 738361 agagatgtcg gtaacctttg agaaagggct tccgttcttt acagcctcaa caaacgattg 738421 cagggcgttt tccggaccct ctgccaaaat ctcgacacgc ccgtcatcac ggtttttgac 738481 ccagccggcc agttttcgct tatcagcttc catttgaaca aaatagcgaa agcccacacc 738541 ttgaacccgg ccgtctacaa tgattcggta ttgaagcatg taaaaaccac cttttctttt 738601 tatgataatc aatcatttta caacctgtaa aggggatgtg tttgtatgaa acaagagcgc 738661 tattcagttc tttctcttaa tctgggaaaa ccgcagacgc ttgaatatga cggaaagaaa 738721 atcgaaaccg gcatcatgaa gcggccggct aaatcagccg tcatgctgta tcgggagaat 738781 tttgaaggag acggacaggc ggacctcgtc aaccacggcg gacctgataa ggctgtctgt 738841 gtctacccgg cggagcatta tccgttttgg gaagagttcc tctcaagacc gctgtcaaat 738901 gccgcatttg gagaaaatct gacggtcgcg ggcctgactg aggagaatgt ttgcatcggg 738961 gatgtgttca gacttgatga agctgttgtt caggtcagcc agccgcgcca gccgtgtgta 739021 aagctggcga aaaagtttgg tgtaaaagaa atggtgctga aggtccagca aaccggctat 739081 acagggtttt attttcgcgt gctggaggag ggcagggtgt ctcccggcgc gaaccttgaa 739141 ttgctgtcca gaggagagaa aggcatatcc gtccagttcg cgaaccgcat caactaccat 739201 gatgcaaaaa atctcaccgc cattgaacgg attttaagtg aggctgcact atcggaaagc 739261 tggagagcgt cctttatgaa aaaaaaggac aggctgctgc cggttgaata gaaaaaagcc 739321 gcgcatatca acgtgcgcgg ctttgccata tttaagattg ttttttcttt gattcaagca 739381 ggttggcaag aaaataggtt ttatagcttt gaagctttct tccttcatgg tgcgtgatcc 739441 cctgcttttt tagttctgcc acataccagc ctttactgcc gtaatgcatg tcagaaaact 739501 cctttcccta tctgatttcg aaacgattgg cattgtaaca tctataaaaa gatgctgaaa 739561 agagatgcgg ggaaaactga gcctttcgca ctagatgtac gaatgttctt ctgaatgtat 739621 atgcggagca aaagccgaat atgatttaat ggccggttag tttgatcatg acaacgccaa 739681 atgtcataat ggcgaaaaca atgccgatat atgtgagcat cccgtttttt ttcttaacgc 739741 cgtaaacggt cataatgatg ccttcaatga aaaaaatgat gccgaaaata ataaaccaca 739801 tgcagataaa ggctcctttc acagacataa tagtagtgta gcatatctga aagagccggg 739861 ctgtgacaat atcaagaaag ccgggcgcat atcgcccggc tcatgtttta ttgtttatca 739921 accaatttga ccagaagctg tgccaaatgt tctttctcat cttcgtctgc aacgctccaa 739981 agctcttgca gcagcatttc ttcaccgttt tgcggctctt catgctttgc gaggtagtct 740041 cccaggatcg cagcgctttt tacaagcttg ccgtcatcca atcccagctt tttgcctcgg 740101 ttgacttgtt ttttcaggta gcctttaaat tcctcaaagt cttttaaaat gtcttctttt 740161 attgtgccat gcatcgcgtt catttcgttt tcaatttgga ttttttcttg atctctgttc 740221 attgcaagac ctcctcgtac agaataatga tgctttacct gcaattggag gaggttaaac 740281 ctgccggaag cccggaatgt gttttacagt ttcgtcagga taatcggttc atcttttgtg 740341 atgacgatcg tgtgttcaac ttgggcaacc atgcttttat ccggcgtctt gaacgtccag 740401 ccgtctccag cttcaacaat cgtttctgct ttcgttgaaa taaacggttc aagcgcgatg 740461 actgtgccat ttttgaacag cgcattatca aacggatcat aatagttcat gatgtggttc 740521 ggcgcttcat gcaggcttcg gccgattccg tggccggtca gggttttgat gacggtaaag 740581 ccttgagagc gtgcttcatg ataaacggct cttccgatct ggttttggcg cttgcccgct 740641 tttgcctgct gaagcccctt ttgaaaagcg ttttccgcgc attggcaaag cttatgaagg 740701 cgttcttctc cttcaccgag cacaaatgag atgcctgtgt cggaatagaa gccgccaaat 740761 tcagcggaga tgtcgatgtt gacaaggtcc cctgctttta aaattttgga tgtgcttggt 740821 atgccgtgag ccacttcatc atttacgctg atacatgtca cacctggaaa atcgtattcc 740881 ttctcaggag ctgaaacggc gccgtgctca tcaagcacag cttttccgat aaggtcaagg 740941 tcttttgtgc tcatgccggg ctctgccttc cgcttcattt cttcacgcgc aagcgcgacg 741001 attcttccga tttttttcag gccttctaat tcttgatcgt ttgttacaat catctgtcat 741061 tcccgctttc tttttaaata atctagatta agcttaccac aactgtctta aaaataggaa 741121 acacacggac ctgggaaaaa agaaataccc ccgggaaaat tggtatagat cactagatat 741181 cttatatggt atatttgaaa aaaaagggta tgagggggat gggtatgctt tcatttttac 741241 aaaaactcgg gaagtcattt atgctcccga ttgcggttct gcctgcggtt ggaattatcc 741301 ttgcgcttgg cagagaggat gtatttaata tcccgtttgt ctatcaggcg gggacggcgg 741361 tttttgatca tctgccgctt atttttgcga tcggtattgc catcggcatt tcaaaagaca 741421 gcaatggggc agcgggttta tcaggggcga tatcgtatct gatgcttgac gcggcaacaa 741481 agacaattga taaaacaaat aacatggcgg tgtttggggg aattattgcc ggtttaattg 741541 ccggttacac ctataaccgc ttcaaggata ccaagctgcc tgaatatctc gggttcttca 741601 gtggcagacg gcttgtgccg attttaacag ccattattac gatcatttta gcgggcatat 741661 tcggagtggt ctggccgccg attcaatcgt gtatcaactc gtttggagag tggatgctcg 741721 ggctcggcgg catcggggca ggcatattcg gcctattcaa caggctgtta attccgcttg 741781 gccttcacca tgtgctgaac aatattttct ggttccaatt cggagaatat aacggagtga 741841 caggggattt ggcgcgcttt ttcgcgaaag atccgactgc gggcacatat atgaccggat 741901 ttttcccaat catgatgttc ggtcttccgg cggcgtgtct ggctatggtt gtgactgcga 741961 agccgtctaa acggaaagcg acggctggaa tgatgattgg atttgcttta acggcgttta 742021 tcacagggat tacggagccg attgagtttg catttatgtt tttatctccg cttttatacg 742081 ctgttcacgc ggtcttaacc gggttatctt tatttatcgt caactggctc ggcatccgct 742141 caggcttctc tttttcagcc ggagctatcg attatgtgct cagctatgga atcgcggaaa 742201 aaccgctgct tctgcttttg gtaggtatat gctatgcggc agtatacttt atcgtgtttt 742261 atgtactgat taaggctttg aatttaaaaa cgcctggacg ggaagacgat gatgtggatg 742321 aagtgctgga tgaaaatact gttcaggatg taaatgaaaa catcatgctg aaagggctcg 742381 gcggaaaaga aaaccttcaa accattgatc attgcgccac aaggctgcga ctgactgtga 742441 aggataccgc tttggtggat gaagcactgc taaagaaagc aggcgcaaaa ggggttgtca 742501 aatcgggcgg gcaatcggtt caagtcatta ttggcccgaa tgtggaattt gcagctgagg 742561 aattgagggc tgctgtcaaa taaaaaagcg gagagggcaa cctctccgct ttttcttatt 742621 tatcttcgtt atcctttgac gtttcggaag aatcttcgtc atgttttgtg taatcataat 742681 cagaaggatt caccttctta aaacctttcg gctcgtagaa ccgcagcagg tctccgttta 742741 tgattttatc ggacatttca agttccttct tgacgagtga gtcttctgac ttgtcgactt 742801 cggattcatc gagttctttt ccggttttcg tgtcgtaata cttaccggat attttcgtgt 742861 acttcggtga aataaagtct ccgtttcgga acggaatcac ttcacggtgt tctttcgata 742921 aaatatcaga accggacatc agatagtcct tcgtatccac tccgagcaga tgcagaatgg 742981 taggagccac atcaacgtct ccggcatatt tatgaacttt ctcgcccttc acgccggcag 743041 cgtggataaa gagcggcacc cgttgaagct gggcgttgtc gtaatcagtg atttcatcct 743101 tgccaagcac tttcgccatc gctttattgt ggttttcaga gatgccgtag tggtctccgt 743161 acatcacaat aatcgattta tcatataacc cgtctttttt cagatcattg aagaattgtt 743221 caatggactg atcaaggtaa tgggctgact ggaaatagtt atcgacgaca gagtcaccaa 743281 agtctccagc cgggaagtct gtatccccct catccattcc gaatgggaag tggttggaaa 743341 gggtaatgaa cttcgtatag aacggctgcg gcaggctttc cagcagcggc attgattctt 743401 tgaagaacgg tttgtctttc atgccgtagt ttttcgtgtt ttcttcgttc atgtcatagt 743461 aagcagaatc aaagaattta tcaatgcctt ccgccttgta catttcgtta cggttccaga 743521 acgtctgcgt gttcccgtgg aaagtagcag atgtgtaatt cttagacttc agaatcgccg 743581 gaacggattg cagcgtgttt tgcgctttgt ttacgaaaac tgaaccttga gccagcgggt 743641 acagagagtt ttccatcata aattcagcat cagatgtttt accttgtccc gtttggtgga 743701 aaaagttatc aaagtagaac gtttcgttat catgtgccag tttatttaag aatggtgtca 743761 cttctttgcc gtcaatttta tagtcgatga taaatgactg caaagattca agtgaaacgt 743821 aaatgacgtt ttttccttcc gctttgccga aatacacgtt attcggcaca tcgtaattgg 743881 ctttcatgta gttttctact tccgttacgt cgctggaatc ggcaagcgcg cgctggctgt 743941 tggacttgat attctgtaca gcgtcataaa tcgtgaaatt gtatgttccc aagtatttca 744001 caagatagtt ccggtcgaat gatcttgtca gcaattcagg acggtctgat tccgcaactg 744061 ccaggttgat caagaacaca agaattgaag acgcaaaaat aattcggaac gattttttgc 744121 ttgacgtttc ggcaggcttg tttactttga tcgccaagat gatcaggatg atcgtatcga 744181 taaagtaaaa ggcgtcagtc ggtctcatca gcgaaaatgc gctgtcaccg agttggccgc 744241 cgtttgtttt agcctgcata atgaccggaa ttgtaataaa atcattgaaa aatctgtagt 744301 acacaatgtt ggcgtacagt aaaaaagaca ttaaaaaatg aatcactata atggctgtct 744361 gctgtaattt tttcttgaac aagagtccaa agccaagaaa gaacaagctt gagctaagag 744421 gattcacaaa aagcaatatt ttttgtatcg tgttgtctat tcctaagttg aaattcagga 744481 cataaccgac atacgttttg atccataaca ggacgaccgc aattaagaag aaggccagtc 744541 ctctttcttt tataaatgtt ttcattgtta cactcctttt ttccgatcca gttcgagcga 744601 aacgatagaa aaaacgaacg tatccaatat aacacgaatc agcagattag aaaagtgaaa 744661 atcgtatgag ggagaaagtg gcgaaaaacg ccgtcgaatc aacgtttcgc tttgatatta 744721 ccaaatgtaa aacaaggtat ctttctagaa ataaaggaat aaaatggtac attgagaatt 744781 gtatgataaa atataaggta tagataaaaa gaggtgaaat gatggatttt tcccatattg 744841 tgtctgaaga taaaattaag cgcgccatca aagacgggga ctttcaaaac ctcccgggaa 744901 tggggaagcc gctgccgaag gatgacgcgg cacacttgcc ggaatcgctg cgcatgggct 744961 atcgtatttt gaaaaacgcg ggaatggcag aggacgaggg cgcgctcaaa aaagagctta 745021 tgaccatcga ccatttaatc gaaaagtgct atgacgaaaa agaacgcgag caattaatca 745081 gaaaaaaatc tgaaaagcaa ttgctgcttg ataagcttgt cgacaaaaaa ggcatgtttt 745141 caaagccagc atccgctttt tataagaata aagtatatga ccggcttgga cgaaacagac 745201 cttcttccag ctgatttgtc ttgtctgcag gatggcgatt gataaaagcc atccttttta 745261 tgttccaagt tctatgtcaa aaggtttatg tttttccatc tatgggaaat gattcataaa 745321 cgaaaaaagg gtgatgggat ggaacgacta ttagtatgga tagagcatat atctgattgg 745381 ctgtggggtc cgccgctaat catcctgctg acggggacgg gcttgtattt cactattttg 745441 ctgaaaggtt ttcaatttcg ctatccttta tacattttca aacagacaat cggcagtgta 745501 ggaaaaaagc cgaagggaga aggcacagtc acaccgcttc aggcattgac ctcagccctc 745561 agttcaacga tcggtgcagc gaacattgtc ggtgtgcccg ccgctattat gtttggggga 745621 ccaggagcgg ttttttggat gtggcttatt gccttatttg ccatggcgat taagttttct 745681 gaaagtgttc ttgctgttca ttacagagaa aaaaatgagc agggtgaata cgtcggggga 745741 ccgatgtatt acataacaaa agggctgcgc atgaaatggc tcggcgtatt cttctctgtt 745801 gcgctgattg tggagctgat tcccagcatt atggttcagg gaaattcggt ttcagtctcg 745861 cttgccgaga cgttttcttt caataaaata tacgcaggaa tcggaattgc atttttgatt 745921 gggttagtgg tgataggagg ggtaaagcgg atcggaaaag taacagagtt tgtcgtgcct 745981 cttatggcag gggcatacgc aggtgccggt ctcctgattg ttctcatgaa tctatcatca 746041 gtgccggcgt ttttctctct cgttttttca aatgcgttta cctcttcttc agcagttgga 746101 gggttcgcag gtgctgcgtt ggcggaaacc gttcgctggg gatttgcccg cgggctgtat 746161 tctaatgaag ccgggatggg aacagccccg attgcacatg cggcagcaat gactgatcat 746221 cctgtgcggc aagggttttg gtctgtgatc ggcattgtca ttgacacctt aatcatctgt 746281 acgactaccg cttttatcgt ccttgcatcc ggtgtatgga cagggaagaa cgcctcaaat 746341 gacccggcag cactgacaac ggccgcattt cagcactatt tcggttctgg aggaggatac 746401 ttcgtttcgg tttccctggt cttctttgtc gtatcaacca ttatggttgt cattttttac 746461 ggcgtaaagc aagctgaatt tctgttcggg cggctggcag gacatgtgat taaattcgtt 746521 tatttagcgg ctattatcat aggtgccgca ggcggagcaa aagccatttg gggcgtattg 746581 gacttagcat tggtttttat tgttgtcccg aatgtgattg cgctcttgtt attgagcaga 746641 aaggtaaaag cgctgtacac cgaattcttt acatctgaac agtactacct gaaagatata 746701 agaaaaacga aacaaaagcc tgtttatcca acaaaagaag ctaaaaattc ctagtgtttt 746761 gcttttgcgc cgaacaatgc tttgcttttt atgatcaaat aaatgagtaa aggcagcaaa 746821 agagaaatca ctacattaat gattggtttg attctgttaa agtcgattag ctgatttgta 746881 tttaaaaaaa accaaaagcc gcatacgact gagaacatgc cggttggtgt atacatggct 746941 ttcgggtcga tttttgagtg taaaaacgaa aggccgtata ccacgatata tagggaacct 747001 gctatcttca ccataatgac cggaatccaa aaagccgcga tgatcaggtc tgagcgatcc 747061 agaaaatccg taatgcggat ctgcctgatg accatataag caggatcaaa gaaagtagat 747121 gtcaggttgg gaccaaagac agaaattgaa gaaaataaca tcacggccag caataaagcg 747181 cccagcagta tcgcgaaaat ggtgtatttt agcgggacgc tccggtttga gaagagaagc 747241 ggaaggataa tcaattcccc cattgtccca aacgcgtaat agcctgattg aaggtatggg 747301 attagacctt caaaaacagg tgtcaagttt tgaagctcaa tttgtgtggc cagcgtaaat 747361 ggaaggaaca agaccaggat gccgaatgga aataggaata tctgcgccat tctggtcaat 747421 gtttcttttc cctctctggc aatacagatc gccacaaaga taataacacc gccaagaaca 747481 gccattggtg ttctcgggag aaataaaatg ttaatcaaat tgatgaaaaa acgtatatca 747541 tgagcattga ttaacaggaa atacaaagaa aacagtaaaa tgataatccg gcctgcgatt 747601 ggtgaggaat cgctcagcag ctcatagata tttttatcct gatgcttttt catcagccta 747661 tgcatgagcc agagtgccgg aatcacgatg acaacgccga ggatgtagct gtgccaggca 747721 ttttgttttg ctgattcgat catgagaatc ggagcatgct ttaatccgac tgctaacgta 747781 tacagagctc cgaaaaataa tccttggtat gcagaggtct tgtccataaa gcacatcctt 747841 tctgtcatgt tcaaaacgga atatatttaa acaggtgccc cagccgcgga agcaggggat 747901 tcactctcat ataaatccat agaaaagcac ttcctgcaat tagcaggctg aaggcccatt 747961 ttgttagatt gttagcggaa cgaaaattct tccattcata tgcgtatatg gcaatgcaca 748021 caatcaatgt ctgtacgata tagctgatca tgctgacgca cctccattaa tggctgatcg 748081 ttttgtatag gacaccgccc tgctcaatcg tcacaattgg gacgacgtga acctccatat 748141 ccttatatac ctcttcccat tcctttttca gcagattctt cgtggttgcc gtgcttctga 748201 tggtcctgtc ttgaaagccg gccgggtccg cctttagctt ttgcaaacga tgaacggtgc 748261 tgatcacgtc cttctttatg gttctgttta atgctttttg aatgatgtaa tactggtcat 748321 tttctctcgt ctcataggtt gattggtttt ccataataat tcctttggct ctgatctcga 748381 ttgtcattga cagctttccg tttttttcag cggcatgaaa ggatgcattg gacttttgaa 748441 gctgaatgga tgcttgcccc atttgattcg gcaggtctac tatgaattct ggctggcggg 748501 cttgattcag caacatcagg gctgctgtca tgtgttcatc tttgaaaata tccatcaatc 748561 tgtccttttt aaagatcgca agcccgtcaa ttttcaaatt agatttgcct ttccctccag 748621 gttttgtttt agatgcagag atgaccggtg catacggatc actgcctatt tctactagat 748681 cagacatgaa tctgcttaag aaaacggggc ggctcgttgc gataatggcc agctcccgaa 748741 tcatttccgc cggaaactgt tcaagctgaa catcggtatt taaaatgtcc cgcgcttctc 748801 cccggctgac taaaatgagc gccgttaatc tgttctgcgg atttcgcgtt aaaatatcaa 748861 agactggggc aacgccgtct ctcgccatat cctctccaat aatgactgta cgtctgtggg 748921 acgtattgat tgtccgtgac aaggaggttt gcagcttgtt gttcgcttct ctgatcgtag 748981 tgccggaagc tgaatcaaca taccatgttt ttgaaccggc agttccgccg ccgccccctg 749041 tttgtccgcc taattggccg accaagggaa tctgcatggc cactcgatac tgatcttttt 749101 tcttatcaat ggctgagctg acaacaaatg caatgtcatt gatttctgtc cggtcccagc 749161 accccgttag aaggatacaa atgagaagcg gcaaaacaca cttatatatt gttttcttca 749221 tcttttgggt cctctctttt cgctcccttc tgtccgttgc cgcgcgaata cgtgcccggc 749281 cttctggtca tcgtccacca aggcgccctg acaaaaatat cttttacttc atctcgttta 749341 aacggagaaa tcccggataa ataaggaatg ccgaaagatt gcagcttgca taaatgaagc 749401 actaagataa tcgtgccgag cataatgccg aatatcccaa aaatactcgc caaaaacata 749461 agcgggaaac gaagcatcct gatggagata gctaagttaa accgcggaat tgtaaatgac 749521 gcgatccctg ttaacgatac gatgatcacc atgggggcag acacaattcc cgcttcaaca 749581 gcggctgtcc caatgactag ggccccgaga atactgacgg tctggccgat ggttttcggc 749641 aggcgcactc ccgcctcacg gagagcctca aaagaaattt ccataatcaa tgcttctatg 749701 atggcgggga aaggaatcgg ttcacgcgca gaggccacac tgaacattaa gtttgtcggc 749761 attaagtcct ggtggtatgt aataacggca acataaatag ccggcaaata taaagcaacg 749821 aataaaaaca tatagcgaag ccagcggatt aagttagaca tcaaataacg ctcatagtaa 749881 tcttcactgg cctgcataag ctgccaaaac gtaatcgggc ctgttaagac aaagggcgta 749941 ttatctgtga aaatggcaaa tcggccttcg agaagctggg cggcgacggt gtccggcctt 750001 tctgtgtatt gcagctgggg gaatggcgag tacgtgtcgt cttcgataaa ttcttcaata 750061 tatccgcttt ctaagacagc atcaatcttt atctttttga ttcttttttt tgctttgtca 750121 ataacctttg gatcggcaag cccgtcaata taggccaaga caacatcggt tttggttttc 750181 gtgccgattt taaaagagat cattttaagc tgaaacgttt tgacgcgaaa gcgcacaaga 750241 gcggtattga ccctgaggct ttcagtgaag ccctctcttg accctctgat ggtcgattct 750301 gttatcggct cttcaatgct tcttctttgt ccgcctttta tatttaagat caggcctttt 750361 gagtgcccgt cggcaaataa aaccgcgttc ccctcaatga tggatgcagc cactttgctc 750421 atactcgttt ctaatgcaac acttgaaatt gatagagtat tttgcagcgc ctcttcatgt 750481 tcatctattt gatccgtcaa atgcattaag aaagggcgga gggcgtgatc ctgaatatgt 750541 tcagatttta caattccttc gatataaaca ataaatccgc acagcccgtt tccaaagtca 750601 aattgtctaa atacgatgtc tgagcagcct tctgttaata aggtcagatt ttcgaggttt 750661 tccttcaaat tgggagagat cggtctgtcc tgattgtctt caagctcttt gatgagctga 750721 agcgctttgt cgcgtttatt catagaggct caccctgctt tttaatgtca tattcaataa 750781 gtgcttgtga cttttagggt aaccttgtct gtttcatata ttccagacta ggatgaaagc 750841 gctataaaaa agtgttgact acctgtatat acaggaatac aatatgatta taagttgtat 750901 atacaagtta taaaaacgga tacggagggg ttggcatggg ggaactgaac aaatcggcac 750961 gtcagattgt cgaagcagtc ggcggtgctg aaaatattgc agcggcaact cattgtgtta 751021 cacgtttgcg ttttgcttta atagatgaaa gcaaggttga ccaagagatg cttgatcaaa 751081 ttgatgtggt aaagggatca ttctcgacaa acggacagtt tcaggtcgta atcggccagg 751141 gaactgtcaa taaagtatat gctgaactgg ttaaggaaac ggggattggc gagtcaacaa 751201 aggatgaagt gaagaaggcc tcagaaaaaa atatgaatcc tttgcagcgt gctgtgaaaa 751261 cgcttgcaga tatttttatt ccaatattgc ctgcgattgt cacggcgggt cttttaatgg 751321 ggatcaataa cattttaacg gcggaaggca ttttcttcag cacaaaatcg attgtgcagg 751381 tttatccgca gtgggcggat cttgctaata tgattaacct gattgcaggc acggccttta 751441 cgtttttgcc tgcgttaatc ggatggtctg ccgtcaagcg gttcggcggc aatccgcttc 751501 tcggcattgt gctcggggtt atgctcgtgc atcctgattt gctgaatgcg tggggatatg 751561 gcgcggcaga acaaagcgga gagatcccgg tatggaatct attcggccta gaggtgcaga 751621 aagtcggcta tcagggccag gtgctcccaa ttttgcttgc ttcttatatg ctggcgaaga 751681 ttgaggtatt tttaacaaaa cgcacacctg agggcataca gctgctcgtt gtcgcaccaa 751741 ttacgcttct cttaacagga tttgcctctt ttatcattat cggcccgatt acatttgcga 751801 tcggtaatgt actgacttca gggcttatct cggtgtttgg ttcttttgcc gcactgggcg 751861 gtctgttata tggcggtttc tactcagcgc tcgtgattac cggtatgcat cacacgtttc 751921 ttgcagtcga cctgcagctc atcggttcaa agctcggcgg caccttttta tggccgatgc 751981 tggcgctttc taatatcgca caaggttcgg cggctctggc catgatgttt atcgtgaagg 752041 atgagaaaca aaaaggcctc tccctcacat cagggatttc tgcttatctt ggcattacag 752101 agcctgccat ctttggggtg aatctgcgat acagattccc gtttatcatt gcaatggtca 752161 gctctggcct ggccggaatg tatatttctt ctcaaggtgt gctggcaagc tccgtcggtg 752221 tcggcggcgt gccggggatt ttctcaatca tgagccagta ctggggcgcg tttgcaatcg 752281 ggatggctat tgtattgatc gtgccgtttg ccggaacata cgcgtatgcg agattcaaac 752341 ataaataaca agtggggagc gggacgtgtt gaacgttccc ttttcccgtt ttcaatttaa 752401 atatggtggt ggaaacagat gaaaacagaa caaacgccat ggtggaaaaa agctgtggtt 752461 tatcaaattt atccgaaaag ctttaacgat acgacaggaa atggtgttgg cgatctgaac 752521 ggcattattg aaaagctgga ttacttaaaa acgctacagg tggatgtgct ttggctgacg 752581 ccgatttatg attctcccca gcatgataat gggtacgata ttcgtgatta ttactcgatt 752641 tatcctgaat acggaacgat ggaggatttt gagcggctag tgtccgaagc acataaaaga 752701 gacctgaaag tcgtcatgga tcttgttgtc aatcatacgt caacagagca caaatggttt 752761 cgcgaggcga tctcttcaat agacagcccg taccgtgatt tttatatatg gaaaaaaccg 752821 caggaaaacg gttctgttcc gacgaactgg gaatcgaaat tcggcggctc ggcatgggag 752881 cttgacgaag catcgggcca atactatttg catctgtttg atgtgacgca ggctgatttg 752941 aattgggaaa atgaagaggt cagaaagcat gtctatgaca tgatgcattt ttggtttgaa 753001 aagggaatag acggctttag gcttgatgtc atcaacctga tttctaaaga tcagcgcttt 753061 ccgaatgcgg aggaaggcga cggccgctct ttttacactg acgggccgcg ggtgcacgaa 753121 tttctgcatg aaatgaacga aaaggtgttt tcacattacg acagcatgac ggtcggtgag 753181 atgtcttcaa caaccgtaga ccactgcatc cggtatacga atcctgacaa taaagaactt 753241 gatatgacat tcagcttcca tcatctcaag gttgactatc ctaacggcga aaaatgggcc 753301 ttggcgccgt ttgatttttt gaagctgaag gagatcctat ctgactggca aacggggatg 753361 cacgcaggag ggggatggaa cgctctgttc tggtgcaatc atgatcagcc gcgcgtcgta 753421 tcaagatatg gagatgatgg cgcatatagg gtgaaatcgg cgaaaatgct tgctacggcc 753481 attcatatga tgcagggcac gccttatatt tatcagggcg aggagctggg gatgacgaat 753541 ccgaagttca ctgacataag ctcctatcgg gatgtcgaat cgctgaacat gtatcacgcc 753601 tttaaggaaa aaggaatggc tgatcaagat attacagcca ttttacaggc gaaatcccgt 753661 gacaattcca gaacccccgt tcagtgggat gctacggaaa atggtggttt tacaacgggc 753721 acaccatgga taccggttgc aggaaattac cgggaaatca atgctgaagc ggcgctgagg 753781 gatcagaatt cggtgtttta ccattatcaa aaattgattc agattcgcaa aatgtatgac 753841 attgtgacag agggtacgta tgagataatt gcaaaggatg acccgaacat ttttgcgtat 753901 ctcagacacg gcagcaatga aaagctgctc gtgatcaata atttttacgg gacagaggcg 753961 gcctttacac tgccggactc tttagcgcct gacgaatgga aggcagaggt gctgttgacg 754021 aacgatgaag caagggaagg gcttcagaac atgacgcttc gcccatatga gtccattgtt 754081 tatcgtttaa cgaaaccgtg ttaaactaag ctgggtggtc cataatgaag gtgaataaat 754141 tcatcacaat ttataaagac atcgcacagc aaattgaagg cggccgatgg aaagcggagg 754201 agattcttcc gtctgaacat gagttgaccg cacagtacgg tacatcaaga gaaacggtcc 754261 gaaaggcgct tcatatgctc gcgcaaaacg gttatatcca gaaaatcagg ggaaaaggct 754321 ccgtcgtgct caatcgtgaa aaaatgcagt ttcccgtttc gggccttgtc agcttcaagg 754381 agctcgcgca aacgcttggc aaagaaacga aaacaactgt acacaaattc gggctggagc 754441 ctccgtcaga gctgatccaa aaacagctcc gggccaatct ggatgacgac atctgggaag 754501 tcatcaggtc tagaaagatt gacggggaac atgtgatttt ggacaaggat tactttttca 754561 gaaagcatgt ccctcacctg acgaaagaaa tttgtgaaaa ctccatatat gaatatatag 754621 aaggagagct cggtctttcg atcagttacg cccaaaaaga aattgtagcc gagccgtgta 754681 cggacgagga cagagagctg ctcgatttac gcggctatga ccatatggtc gtggtgagaa 754741 actacgtctt tttggaggat accagtttgt ttcaatatac ggaaagcaga caccgtctcg 754801 acaaattccg atttgttgat tttgcgcggc gggggaaatg agagaggcgc ctgcctgcgg 754861 cagcgcgctt ttttgtttgg tatcaaaatt gatactatcc aacaaaaatg tgcgtacttt 754921 tactttttat cataatggct acaatagaga tgagagtaat ctaaaggaga ggtgttttac 754981 atggcagatc taaagacaca aattctggat gcatacaatt tcaggcatgc gactaaggaa 755041 tttgacccga ataaaaaagt gtcagacagc gattttgaat ttattttaga aacaggaaga 755101 ctgtctccga gctcactcgg ccttgagcct tggaaatttg tcgtcgtcca aaatccggaa 755161 ttccgcgaga agcttcgtga atacacatgg ggcgcgcaaa agcagctgcc gaccgcaagc 755221 catttcgtcc tgattcttgc gcgtacagcg aaggatatca aatataatgc ggactacatc 755281 aaacgtcatt taaaagaagt aaaacaaatg cctcaagacg tgtacgaagg ctatttaagc 755341 aaaacagaag aattccagaa aaacgatttg catttgcttg aaagtgacag aacattgttt 755401 gactgggcat caaaacaaac ctatatcgcg cttggcaaca tgatgactgc cgctgcgcaa 755461 atcggtgttg attcctgccc gatcgaaggc ttccagtacg atcacattca ccgtattctt 755521 gaagaagaag gccttctgga aaacggaagc ttcgatattt ctgtgatggt ggcattcggc 755581 taccgagtga gagaccctcg tccgaaaaca agatctgctg ttgaagatgt tgtgaagtgg 755641 gtttaaaaga agaaagctgc tcgcatagcg agcagctctt ttttatgcct gattcgctct 755701 attctgtttt ctcctctgat gtaagtacat tgccgttccg agtgcgctga tcagaaatcc 755761 ggccaacagg atcgagtaca tggatgtggc tgtgtccgga agcaggccgc cagccggacc 755821 gtctgttcct gatccgcccg aaccgtttcc accagagccg ttagtcggtt gagtgccggg 755881 aggcgtatca tttcctccgt ttccgtcagt tggctgtttt ccgcctggtt tgtcggagcc 755941 tccgccatga ttgccgtcat caccgcctgt cggttgatct gacgggaatg ccggcggttt 756001 gttgtttgaa ccggaattta agatcgtgta ttcgctgaag tggtttgtat atcctgtcac 756061 catatcatca tcgactgatc cgtgacctgt ctttgtgaaa gctttctttt ttctatcgac 756121 gtgataaatg gcagggttat gggcttcttc aatatcaaac atgcgaagcg aaagctgtac 756181 gggctccttg aatgatttta tttcttttcc tttttgcttc actgtaaagt catatacatc 756241 tgacagtgac acatccaatt ctcccgtaga cttgattccg attgcagtgt ctgcggtttt 756301 aaggttcgcc attggcatct tcatgctgta ccagtagttg aacatcgtca atgaaggatc 756361 tgactctctt tctttcaaaa gtttgacctg atcttttttc actttaagat tgataggctt 756421 ctcttgagat ccttcatgta ttccataata gacaaatggc gtgttggcat ttttagcata 756481 aatcgcaaat ttgtcttcat caagtgtcca gctgccgtcc ttctgctttg tcggcaggaa 756541 tacttctttg attcgtcctt caactttagg agagaccttg tttcctagtt ttttcagctg 756601 ttcggtgaaa atctcataat caacgtagcc aaggtcttca ccatgggagg cttctgtaaa 756661 gacagaatat ccgtctcctc cggcaccgac aaaattattt gttgccacgc ggtaggtatc 756721 atccgtattt atagcaactt tgtctccgtt aggcgattca attttcactt ctaacacacg 756781 gtgtccaggt ttgttgttta atgtaaaggt atattcgatt ccggccacct gagggaaagc 756841 gccgccgcca ttttccacat tgcttaggcc ttgttcaagg gcttctttaa tttgttttcc 756901 ggttaaatcg gccacgtaaa gcgtattgcc gaacggcatc acgttgagca cctcgccgag 756961 tgtgatatca cctttgtcaa tgcctgctct gatgccgccg ccatttgtta tcgctattct 757021 ggcgccggct gcttctttcg cttttgccag cataccgtcc gcgatgaagt ttccgagatt 757081 cgtttctttc gtgcgcacat gctcacgctg gccgtcaagc gccacatccg tgtagccgac 757141 tttttcattt ttcacgtcct ctaattcatt tttgaactga tcgagctctt gttttgcttc 757201 tgggttttct tctgtatgtt catcaattgg cagcacgctc agatttgatt tatctgtttg 757261 cacaacgcct ttttcatcaa acgcgacatc aacgcgcccc aagaattggc cgtattcttt 757321 tgcctgcgcc acgatcgtcg gttcttcgtt gttcacgacc tccattttgt ctacgagggt 757381 gtgagtgtgt ccgccgatga tcaaatcaat gccttttact tttttggcta gctcaagatc 757441 ccggttatgt ccgatgtggg ttaaagcaat aattttattt accttttctt cttcttgaat 757501 cgctttgacg gtgttttgtg ctgtttcaaa ggcatcattg aatacgatgc ttttgcccgg 757561 gcttgatgtg gtggctgtat cttctgttgt caggccgaat acggcgactt tctccccgtc 757621 aacgtctaac agaatgtaag ggtgaatgcc ggcctctttc ttttcacctg ccgtaaaggt 757681 ttgcggcttt ttgacaaatg atttcagctt gggctcattt gacacatcta cgtttgcact 757741 gacaatcgga aattccggcg cttcaaagtg atagcggttc gccggatcaa cggttgcgct 757801 gtttccgctt agaaaatcag aaagcaccgt cgggcctttg tcaaattcat ggtttccgaa 757861 ggtcatggcg tcatagccca tcatgttcat cattttcaga tcggccaaac cgttccattt 757921 agtaaaatac agatcgccgg aaaacacatc tcccgcatca aggagaatat tgtgatttgt 757981 ttcgctgcgt acttcgttga ttttcgtcat tcgtctcgct gcatcatcga gatgggcgtg 758041 cgtatcattg gtgtgcatga cggtcagatc ccacagtccg tctttaggag gatctggatt 758101 tgaatcatca tcgaattgca gcttatacac accatagcct tcattcgcag acttgcctac 758161 ataagcgaca tcgtctgctt tatcggcaaa tggcttggcc aaaagcgagg attcaaacgt 758221 cagattcgtg ccggaaacag gcgcgattga ccagttgttg tctgcttttg gattgactgt 758281 tttttgttca ataatgtaat ccatcagcac ctgcctattt tcaactgcag agccgtggac 758341 aattttatcg ctcgtcagat gagggaaccc gccgcctccg gacgcacgat agttattggt 758401 gactacgaga aattcctggc ttgggctgat cggcttgcct tcataggaaa gattgatgat 758461 acgggatgaa tccgcattga tcacttttcc gttctcattg tatttagccg gttttgtcac 758521 atcgacctga tatgtgacac cgtcaatcac gtcaaaatta taggagcgga aattctcgtt 758581 cagcaaggcc tggtcgccgc ctttagctgg atcaatttga ttgaattggc ctgctgacat 758641 ctccagccag tccttgacct cgctgcctgt cagcttgacg atttgaacag tattatcgta 758701 aagatacaag tcaccgacat ttttaatcgc aagatctccg gctggaatgt ttgtatagta 758761 attggctccg tttctgccgc ctgctttaaa cggcgctcca gcggataaaa tcggcaggtt 758821 cttgtactcg gtatccttca tttctttttc agcgtaccac ttttgcgcgt cagtcacgat 758881 ctgaatggaa ggatcatctt tgacctgtgc aaagaagctg ttaatatctg cttcggtttt 758941 gccgactggc tttcggacat actccagtgt gttttggtgt gtttgctgaa tggtgtttgt 759001 aacggtttcg tttcttgatg tgacgttgcc agcaatagat tcaatacttc ctttggaatc 759061 tgctaccttc catgagccgt ccgccttttc aagcttgagg tcaatcacgc ctaaatattt 759121 gccccagctg cttggcatga cgacaggaat gccgttaatt gttccctttt ccacattgaa 759181 ctgagcaaca cccgcatact cggcggaagg aaagagtccg tgctgatggc ccgagataat 759241 cgcgtcaatg cctttcgttt tggtggcaag gtcaaacacg gcgttttctg cgcctgatga 759301 ttgcgcctgc ttttcaatgc cggtgtgggc gagggcaata atgacatctg cgccttccgc 759361 cttcattttc gggatcgttt cattggcgga ttctacgata tcctgcacct gaacttgccc 759421 ctcgagattc tttttgtccc atgtcatgat ttgcggcggg acaaagccta tgtagccgac 759481 ttttactttc tgctcattac cgttttcatc aatgagggtt ttttcattaa tcacatacgg 759541 cgtataacgg ttttcgccgc tagttgtttt gacgttggca tttacaatcg ggaaatcggc 759601 tcctttgatt gtgccgtcga gaaagtcgag cccgtagttg aattcatgat tgccaagcgt 759661 tccggcgtcg tatttcagcg cattcatgac gctgataatc ggatgggttt tcgtgccgga 759721 gataatgtcg tctttttgat atttcaccgc gtattcaccc agcggattcc cttgaatcaa 759781 gtcgccgtta tccacaagca gggtgttagg gttttgctcg cggtgctttt ggatcaattg 759841 cgctgttctc gccagaccga aatccgccgt ttctttgtcg ctgtagtaat cgtaatccat 759901 catgttggca tgaatatcag tcgtagccaa aatactcaga tgcacctgag gagccgcgct 759961 ttcttctgca tgaatgggtg gtgttgggag gattaggcta agtatcataa ttgggggcaa 760021 aagaatacgg agaatgtttt cgacgtgtgt tcgtcttttc tgtattctca ccagttctcc 760081 acctttcaac gaaatttgtg ttacagctcc tattgtaaga atattttgta actatttgta 760141 ggtgtttctt tatgattatt gtaaaaggga gaaaaatgag tattatgtag cagtatcaaa 760201 cgacaaatac tgggcattta tgcttatcgt ttgtcacaat cgcggaatgt ttattttagt 760261 gtggctgggg tagagtgttt tatgtagaca tataaagcgg gaggttatga atcatgggga 760321 aaaaaattgc agttgtttta acatattatt ttgaggacag cgagtacact gagcctgcga 760381 aagcctttaa agaagcggga catgaactga ctgtcatcga aaaagaaaaa ggaaaaacag 760441 taaaaggcaa gcagggaaca gcggaagtga cggttgacgc gtccattgac gacgtaaatt 760501 cttcagactt tgatgcgctt ttgattcctg gaggattttc accagaccag cttcgcgctg 760561 acgatcgttt cgtccaattt acaaaagcgt ttatgactga caaaaagccg gtatttgcca 760621 tttgccacgg cccgcagctt ttaatcaatg cgaaagcgct cgacggccga aaagcgacgg 760681 gctatacgtc cattcgtgtt gacatggaaa acgccggtgc cgacgttgtg gacaaggaag 760741 tggttgtttg ccaggatcaa ttggtcacta gccgcacacc ggacgatata ccggcattta 760801 accgcgagtc attggcattg cttgagaaat aagaaaaaac ggacgctctt gggcgtccgt 760861 ttttttgttg cttaggcttg agcacctgtc agtttcttgt acctgtaata caagaaagca 760921 gctgcagccg ttccgatgac cgcaatgccg aagtcgaata tgaaaatatg ggcgatgccc 760981 cccgcttttg cgataagccc tgttgcaatc ggcagcagaa tcgatgcaag acttgaagca 761041 gtcgctacaa ttccggtaac ggttcctttt cgcttccaga aaagctctgt cattaacgta 761101 atggtaattt gaaacacacc cgcagttgaa aagcctaaga aaaaggcagt gatgtccagc 761161 acaactggga tatgaacggt cagcatgact gcgagcgtac ataaagtaat aataggatat 761221 aagagcgtta tgaagacagg tttgacccat ctattcagca aaacggctaa taataaaaca 761281 gatgccagag atcctatact ataatagctc agcaattgta cagatgctga ttcagctaaa 761341 ccggctgcct tttgcgcgta gctcgggagc cagatttgag aaaccgtaaa taaagccgtg 761401 gatgtaaaac cgatgataat cagtgcggtg ccttccttct gaaaaacggg ttcagacaag 761461 aaaacgggag attcctgttg gccgctatta gttggtttct tatgtttttt aggaaacgaa 761521 agcgttgata aataaataat attcaggaga tagaccgctg ccggcagata aaaagcaaat 761581 ccgtaaaaca tgctgtggtc tgctaaaaat gtgatcaaaa gcggcaaaag tgcggccccc 761641 acagacataa aggctttaac caagacattt gccgaaccgg aagcagacgg aaagagctcg 761701 gttagggccg gatatgttcc ggcatccatg gctgaattag cgactccggc taataaagcg 761761 aacacaaacg ccagctcata gctcggtgat aaaggaatac cgactaaaaa gacggccata 761821 attcccgcag aagcgacaac aagcggcttt ctgccgattt tatctgatag aacgccggaa 761881 atgccgtatg tcagcagttt gccaaacccg atagcggcaa tgacataact gatgccggtc 761941 ggatcggtat tccactgttt tgttaatgaa gacatattgg atgcgagaat gatgttgacc 762001 atccccagaa agaagtagtt gatatacatt ccggatgctg ttttgataga tgtcgtttgc 762061 atgcttgtac tccttcaaat cttattcgaa cactttgctg ttttggtttg gggaaatgat 762121 aaaaaagact cgccgagttt ccggccagtc tccattattt acgaagcgag gctaattctt 762181 gagcaatcgc ctgcatttca cttgggctga atgattcttt tttcatcacc attctgtgaa 762241 ggtacgtgag gtcttcaatc ttctcatcac tgaaatcctc cgctttgatt acgccgacgt 762301 tcagcatgtt cagcttttgg gaaatctctt caatcatttg agttaatgtt tctgtatttg 762361 ggctggacaa agggttccat cctttctatg cgcaatatag gtatgtttta ttctaacaga 762421 attccatcag aaaaaaaccc tattctaaaa gcaggctgtt cattccaaaa aagtgaagac 762481 atcagttgaa aagaaaatga acatcctact aagatattca tgaaggtttc tttttagaga 762541 aataggggca aagaataggg aggttgcaca tcatgataag cgtgttattt gtttgtttag 762601 gtaacatttg ccggtctccg atggcggaag cgatttttag ggacctggca gccaaaaaag 762661 gattagaggg gaaaatcaag gcggactcag ccggtattgg cggctggcac atcggcaacc 762721 ccccgcatga gggaacgcag gagatattgc gcagagaagg aatcagcttt gatggcatgc 762781 tggcgcgtca agtcagcgaa caggatctgg acgattttga ttacatcatt gcaatggatg 762841 cagaaaatat cggaagtctc agaagcatgg cgggttttaa aaacacctcg catatcaaaa 762901 ggctcttgga ctatgttgaa gattcagatc tggctgacgt acccgatcct tactacacag 762961 ggaactttga agaggtctgc caattaatca aaacgggctg tgagcagttg cttgcatcca 763021 ttcaaaaaga aaaacaattg tgagtgaaag gagaatttgc atgaacaacg aacgtttaat 763081 gctgaaaggg atatttctcg gagctgcggc aggcgcggcg ttatcactgc tccataagcc 763141 gacaagacag gcgtgcggga tgagatggct gacatgcaag cataaacttt cactgtacaa 763201 aagcaaccca gagctgttaa aaaacactgt catcacaaaa gtggatgagg ccaaaaagct 763261 cgcccgaacg ctttcaaagg aagtcgactt tgtgaaccag caggtgaaag agctgaagaa 763321 aacaacgccg caagtgatgg aactcgtgca agaaacgaaa gagcattttt caaaaaaatg 763381 atcaaacatg cgaggtgaga cgacatgagt tttttgaaag agcttttcag cagatacacc 763441 cttcatgaag gacaaagtaa atcagcggag ctggcgtatt tttttctatt gtcactgttt 763501 ccgtttttga tttttatgct gacgctcacc gcgtatcttc cgctttctac cgatgatgtt 763561 ttaggagtca tagaacaata tgctcccgcc agtgcgatgt cactcgttga atccattacc 763621 catcaaacct taaataatcg aaatggcggt ttgctgtcat tcgggattat cgccgcatta 763681 tggtctgcgt ctaatggaat gaatgcgatc gtccggtcgc tgaaccacgc gtatgatgtg 763741 gaagaaaacc gctcttttat cattgttcgt ctaacctcga tttttttgac gattgccatg 763801 gtatttacga ttttagtggc tttgcttctg ccggtatttg gccgggagat tggaaggctc 763861 gcttctgact ttgtcggcgc gtcggatctg tttttatccg tctgggccgc cattcgctgg 763921 ggtgtcagcc cgcttgtgct tttgattgtt ttttccgcgc tgtatgtgat tgcgccgaac 763981 aaaaagctgt ctctccggtt tgtcatgccg ggtgcggtct ttgcgactat cggctggatc 764041 attgtcagca cattgttttc attttacgtc agcacgtttg cgaactatag cgccacttac 764101 gggagcatcg ggggaatcat cgttctgatg atttggtttt acttgagcgg cattttaatt 764161 atcctaggcg gagaaatcaa cgctctttta cataaacgta aaaagcttcc tgatgaaaat 764221 ccctaccatt agcgcaccct ataaacgaac ttcggttcaa aaagaagtcg gggggatatc 764281 gtgatgacca agcatacgaa aaaaggcgga agccataaca aacaaaactc gaaaagcaaa 764341 tcgagccata aaacaagcgg aagcgccaac ggacaaaacg gctaccatta gcataaaagc 764401 ctcctgacat gatgtcggga ggctttttga ttaagaagat gaagaatagg tttcagccgg 764461 tgaccagctt ttcggtttgc ccagcacaag ggccagccac acagagctaa gcgtgagagt 764521 aatgaagtag aacaagtttg cgctttcaaa tgtctgcata taccagccgc cggcaactgg 764581 gccgaggatg ctaccgagac tgaatgtaat gccgcaaagc aggtttcccg ccggcaggag 764641 gtgaggcgga agaaggtctg tcatatagct gatgccaagt gtaaaggttg atccgactgc 764701 cattcctgca ataaaaaagc agccgccgat cacgtagggc gaaggaaata caccggcgat 764761 gaaaaagcaa agagccccag tcagtaaaat caccagcagc acattccgcc tgccgtattt 764821 atcgctgagg atgccgagcg gaaactgaaa gataatgctt ccaatcgcaa atgcgggaag 764881 gatgatcgct actgcgtcta ctgatatccc caaacggagc gcgtacaccg gaaagcttcc 764941 gttcagcgcc gtttccagaa agccatagcc aaatgtaggc ataaaggcaa cccacccaaa 765001 cagcatggcc tgataaaatc gcctgaaact attgtctgat ttggtttcat gaggactggt 765061 ttccgggtat gcattttgta gaaagaaaac aaaaagccac gcaaacagac tgatgcagcc 765121 ggacacgata aaaggaagcg acggactcag cttgacaagc ggcaccatga acgggcctgc 765181 ggcaaagcca aggccaaagg aaagcccata aatagacagg tttcttccgc gattttgttt 765241 tgatgacatg gaggtcaccc acgtttgcgt agaaaagtga agcatgtggt cgccgattcc 765301 aatgaacagg cgaagcagga accagaccca aactgactga agccaaataa atccgaataa 765361 gcttaaaatg acaatgcttc cgcccatgac gatcagcggc ttgaacccga gctttctgag 765421 cggtgcttcc ataaacggcg aagccaaaag cacaccgata tacagcccgg tcgcgtgcag 765481 gccgttgata gcagcggatt ctccatttgt ttcaaaaatg attgaaatga caggcagcag 765541 catgccttgt gaaaacccgg aaatggaaac gagcaagaca aggataaaga aatgaaatcg 765601 tgacatcgtg tcagttctcc ttatatggaa tctatgttga tcgtacaacg ttttccaaaa 765661 gcaggcaacc tgaaaaaagc ctatatcacg ctatacattt gccctcgtgt aatcatgaag 765721 gtttttgtga agaataaaaa taaaacaagt cataaaaaag gagctatttc accatgaatc 765781 gtatcttttt tattttagtg gcggccggtg ttccgctttc tgtgattggc agtttgatgc 765841 attggccttc cgcggttcta tttgcagttt attgcgtgac gattatcgcg cttgcaagct 765901 atatggggag ggcgacagaa tcactgtcca tcattgcagg accgcgtatc ggcggtttgt 765961 tgaatgcaac cttcgggaat gcggtggagc tgattatttc cctttttgca ttaaaagaag 766021 gcctgacagg aatcgtgctt gcctctttaa ccggttcagt gctggggaac ctgttgctgg 766081 tagcgggcct atcgtttttt gtcggcggtt taaaatataa gcggcaggaa tttaatatcc 766141 atgatgcccg ccataactcc gggcttctga tttttgccat cattgtcgcc tttgtgattc 766201 cggaggtatt ctctgttggt atgggaaacg ccagcaagct caatttaagc atcggcatca 766261 gcatcattat gattctgtta tatgtggcgg cgctgtactt taaacttgtc acgcatcggg 766321 gcgtttatca gccgaataat gccgctcaga ctgaagaaga ggaagagcca gaatggtcag 766381 ggaaggttgc gacgattgtc ttgtttgcgg caacgattgt ggttgcatac atatccgaaa 766441 acctggtcca tacctttcac tcggtggctg aacagttcgg gtggagcgag ctgtttattg 766501 gggtcatcat cgtggcgatt gtaggaaatg cggcggagca tgcgtcagcg attattatgg 766561 ccttcaaaaa taaaatggac attgctgttg aaattgcagt aggctctacg ctgcagatcg 766621 ctatgtttgt cgcaccggtt ctcgtcatct gttctatctt ttttccgaca agcatgccgc 766681 ttgtatttac attgcctgag ctcgtcgcga tggtatcagc ggttctcttg atgatcgcga 766741 tttcgaatga cggggattcc aactggtttg aaggggcgac actgcttgct gcatatgtca 766801 ttatggcgat cggctttttc cttctttaac ctgaaaaaat gatggataac aacaaagcgg 766861 gatgaaaaga ctaagggaaa atgccataga aagagtgata tgatgaaaaa gctatttcat 766921 tccacactta ttgtgttgtt attctttagt tttttcggcg ttcagcccat ccacgcgaaa 766981 aagcagttta aggttcctaa ttctgtcgca agcatttcaa aggaaaacac gtatccgaat 767041 gcttcacagg atcagccaat gcttcagccg agcaagctgg caaaggaatt gctcgatcat 767101 tctgaggtaa agattgaaaa tccgcatctc atcaaaatgc tgaatgaatc caacatatcc 767161 ggcacaccgc ttgcagtagg gtaccgggcg acaatatttc tcgggaaatg ggcgctcggc 767221 tatgaatcaa atgaaacagt cgcaaactgg gaatataaaa aaatcaatac aaaccgtgcg 767281 gataaccgcg gcgggaaaga aacggctgaa atgcattatg cccaggaaca gcagtacaga 767341 gtgaagggcg gcttgacagc taaagttcca aatgctgaag atgtcaaaag catgatgatg 767401 caaaaagcaa tgaagaaaac gaacctcccg cttgcatttg agacggtcat cggggctggc 767461 acaaaacggg atcagattta taaagtcgct cctaaaaaaa tcggttatct acatgcatat 767521 gcaccggctg tgaatgaaaa aggaaaagtg acttacggag aagtgtactt agtgctgaaa 767581 ggaaataaac gaaaactcgt cgtgaaaaat gtcacgtcac agggaatcgg cgcgtggatt 767641 ccggttcaag atcatgtcac gtttggcttt cagctttcct cactgccaag ataaataaaa 767701 aactgattcc aactcggaat cagttttttt gtttattggg ttctctcgat tcggaccgct 767761 tcctcaagca tttgcacatt gttttggtag agctggcgaa cgagaacccg tcttactgca 767821 aggctggcac tgaaataatc atcatctttc accatgcctt taaccgtaaa ttcgacgccg 767881 cgattgattt tattcaatgc ggtgatgccg tggatttgaa acggttctgt cggattgccg 767941 aattcatccc gcttcaatga atcacgaagc tcttcattca gcatgtcaca tgcctcttcc 768001 aacacgctgt acacgcggtc cggatcttct ttaaagctga taagaaagga ttcggtaatc 768061 cgcataaaat caatattata gttctctatt tgtctgacct cgccgttgct gatggtgagc 768121 agcttcccgc tccattcccg gatttgcagc gagcggaggc cgatttcctc cactgtcccg 768181 ttgaacaagt tgttgacggt gacataatcg cctttgtgca gctggcgttc atatattaag 768241 aatacaccag ccagcacatc tttgatcagc gattgggcgc caaaaccgat cacgatacct 768301 gctacgcccg ccccggccaa tatcttgccg aaatcatgca caaataaaga aataacgtaa 768361 aagataaaac caattgttgc cgtatactgg gtgacagaac ggacaaggct ttcaatcgtt 768421 ttttcctttt tttcttcaat aaagtccgtc cgtttaaaaa atagctgtac cagccggttg 768481 atgataaaga caccgatcca aaggataacg gcaacgagga gaatatcgac gattttattt 768541 tgaaaaatct ccgtaagtgt ttctttcatc cgcatctaac tcctggcttg acgttttgtg 768601 aagtctgtat cctgataata actgtttttg acaagaacat tcggtccgag gcaccggaca 768661 ttcgggcagt ggcaactcag ttctttcgca agcttggtct ctctccactt ttcataggcg 768721 gaagggaggc tgtccgtctg aatgttgcca agcggcgggg tatcaccgaa atcggtcacg 768781 ataatgtttc cgtcgaaaat gttcacattc aggcgggatc ggccgtcagg gtcatttcgc 768841 actgtgacgt ttttcgccgc gcgaagccgg cgaagcagct tttggtcgtc ttcgtccgga 768901 ctgcaggcat aaaacggcag cgttccgaac agcatccacg tattttcatc acgaatatcc 768961 agcaagcggt gaatggcctg tctcatctct ttcaggctga gggattcaag agcgcttgcg 769021 aaatcgcttg gatacattgg gtggacctcg tgacgctgac atttcatatc ttctgtgatt 769081 tggcggtgaa tatgctcaat atgcggaagt gttcgtttgt tcagcatcgt ttccgcagat 769141 accattactc cggcatccac gagcgtgcgg ctgttttcga tcattttttc aaaatagcgc 769201 gcgcgctgtt cgaaggtcgg ttttctgtcc atcatggcaa agccgatttc agcaaaatct 769261 tcaactgttc cccagttatg tgaaatatgt agcacatcga gatacggaat gatccattcg 769321 taccgctcga tgtcgagggt cagatttgaa ttaatttgtg tccgcacacc ccgttcatgg 769381 gcatatttca ataaaggaac aacatattct tttactgatt tcaacgaaag catcggctct 769441 ccgcctgtga tgctgatgga tctgaggcgc gggatttcct ccagccgttt taacagaaga 769501 tctattggca gagcattcgg gtctttaggc tgcaatgtat agcctacagc acaatgctcg 769561 catctcatat tgcacagtgt cgttgttgtg aattcaacgt ttgtcagctg catgtctccg 769621 tattggtcaa catccatata ggcttcccaa gggtcaaact cgggcgtaat cggacgcagc 769681 ttcgtgtttt gtgtcatgac tatctaactc ctttataaat gggcatacta acgctgccaa 769741 cagttaattt tagacctgat ttgccaagat cgcaagtagc gcggcgattg aaaaacggca 769801 aaaaatgagc taccataata aaaaatgaat ggaggaacag aatggggaac gccgtaaaca 769861 ataaagatca gcagattgat tatttaaaga acagacttga catgtttatg aacgtcatcg 769921 attcattaga ccctgaagca accgacgttg aagatataga caggcttatc agcatgcttg 769981 atgacctgga agccaaatac gaacgtttta aaaaagattg ggaataaaac cgcgtgcccg 770041 ccgcggtttt tttattggca taaagcaaca gtataaaaca aagtctctat ctgtaaaata 770101 agaaaaaatg cagaaggagc gctggccatg aagtggatgt gttcaatatg ctgcgccgcc 770161 gtattgcttg ccggaggtgc agcacaggcg gaagcggtgc cgaatgagcc gattaattgg 770221 ggctttaaac gaagtgtcaa tcatcagccg ccagatgccg ggaagcagct gaacagttta 770281 attgaaaaat atgacgcgtt ttatttaggg aatacaaagg aaaaaacgat ttacttaacg 770341 tttgataacg gatatgaaaa tggctatacg ccaaaagtgc ttgatgtctt aaaaaaacat 770401 cgcgtaacag gaacgttttt tgtcaccggg catttcgtaa aggaccagcc tcagctgatc 770461 aaacgaatgt cagatgaggg ccatattatc ggcaatcatt cctttcacca tccggattta 770521 acgacaaaaa cagctgatca gattcaggat gaacttgatt cagtcaacga agaggtttat 770581 aaaattacgg gaaagcagga caacctgtat ttgcgtccgc cgcgcggcgt gttcagtgag 770641 tacgtactga aagaaacgaa acgcctcggc tatcaaaccg ttttctggtc ggtcgctttt 770701 gttgattgga aaatcaacaa ccaaaaggga aagaaatatg cctacgatca tatgatcaag 770761 caggcgcacc cgggagccat ttacctgctt cacaccgtat cgagggacaa tgcagaagcg 770821 ctggatgacg cgattacaga tctgaaaaaa cagggctaca cttttaaaag cattgatgat 770881 ctgatgtttg agaaagaaat gaggctgccg tctttgtaaa agagaaagac ctctccttaa 770941 acggagaggc ttttctttat tttatacatt taatcagtgc ggcccagtcc agatccccga 771001 agcctttctc aatcccgctt tcaaaatggc tcttggccag ctcggcaaga ggaagatttg 771061 cagaaacccg ttttgcggcg gcgagtgcca ggttggtatc cttcagccct aaagacattt 771121 tgaagccggc cggctcaaat ttctgctcgg ccataatggt tccgtaattt tgatagactg 771181 gagaaccaaa gagcgcgctg gcgatttcta aaaattgttt ttgttctaag ccgtatttct 771241 ccatcattaa aaaggattca gataacgcct ccagcatgga cacaagcaag aaattaatgc 771301 tgattttggc tgcatttgcc gtcttgcttt cttcgccgac gtcaaatatc tgctggctca 771361 ggctgtcgag cagaggcttg gcagcttgct ttgcttccgc cggtccggct gttatgatac 771421 ggagcgcggc tttggctgcg gcatccggtc tgccaaggac aggagcggcg agaaaaaatt 771481 gtcctttctc tgcatgagcc gctgcgagct tttctgagaa ctcaacactg attgtgctca 771541 tcgagatgtg tatgccgttc tctgctaatc cttcaagcag cccgtcttct ccgaatgtca 771601 cggtgctgac agaatcatca tctgcaagca ttgtgatgac aatatcagcg gactttgccg 771661 ccagccgcgg cgtatcagct gcctgtgcgc cttctgtgac aaggtcttct gtcttttgtt 771721 tcgtccggtt atagacagtc aattcgtagc ctgcttgaag aacatttcgg gcaatgggct 771781 gtcccatatt gccgagtccg atgacagcaa ttttcaatct aatcactccc tgaatatttt 771841 ttccattata aacaatatga acagaatatg catagcgatc ggcttacaac aaaaaagaac 771901 agctgctcgc tgtcctcatt taaaaatatt gaaccatcct ttatgtacaa accaaatcag 771961 cattccaatc acaagcgcgg ccatcaggcc aagtacagcg aaatatccgt atttccaatg 772021 cagctccggc ataaagtcga agttcatacc gtatacaccg gcaataaagg tgagcgggat 772081 gaaaatggtt gatacgatcg tcagtgtcat cataatcgca ttcatccggt ttgagtttag 772141 cgtcacgtag ctgtcacgca agtcggacgt catgtcacgg ttggattcca caatttcaga 772201 caactttaac aaatgatcat atatgtcgct gaaataggct ttcgtttccc gctgctcttt 772261 cacatggtca aggcttaaaa tccggtagag caaatcacgc atcgggataa tcgtccgtct 772321 caaatgcaat aggtctgttc tgagatcaaa cacctcgttc atcagcgttc catacgtttt 772381 gtggggacgg ctttcttcaa tttcattcag ccggtcttca attttataca cgagaggaaa 772441 atattcatca acaagctgat ccatgatcat ataagaaata tgcccgggcc cttttttcaa 772501 tatgtccggt gaagcataca aacgctcccg gactttagcg ataccgggcg tttcgtgtaa 772561 atgaaaggtg acgacaaatt tttcgccttg aaagatatcg acttcctccg tctcaagtgt 772621 ttccttattc agcgcatgaa tcacgtaaaa acgatagccg tcataatggt caagctttgg 772681 ccgctgcata tgctggaagc aatcctcaat ggcaagcggg tgaaaatgaa aaaaatctct 772741 caataacgcc gtttccgtat cctccgggcc gtaaaaatca acccagtacc atgcaatatc 772801 aggctgttcc actcgttcga tcggtatatt tttcagcagc tgatgctctg ttgtgattgc 772861 ggtaatgttg atcataaaca accctccacc tgccattata tcatgcggtc tttatgagaa 772921 aagtatacgg tactctctgc ctaattccag cggcatgtta tactgaacaa aaacggaaaa 772981 aagggtggat ctcatgtgga aggaaaaagt atctgtcacg cctccgtatc attttgaccg 773041 cgtgctggac aggctgtctt tagaccccct caatgctgtt gatcgagagg cgagggaagt 773101 ccgtgtgcca atcagaaatc aagcggggga cgtatgtatt gtaaaggtac aggcgttagg 773161 ccatgcgggc gagcctgagt tcctcgtcag cggggaaacg gatcagggag aaatgatgaa 773221 ggaaatcaag cggatttttc aatgggaaaa tcatttgcag cacgttctgg atcatttttc 773281 aaaaacgagc ctgtccgcca tttttgaaga gcatgccggg acgccgcttg ttctggacta 773341 cagcgtgtac aactgcatga tgaaatgcat tatccaccag cagcttaatc tttccttcgc 773401 ttacacgcta acagaacggt ttgttcatgc gtttggcgag cagaaggatg gcgtgtggtg 773461 ctatccaaag ccggaaacga ttgcggaact cgattatcag gatctgcgtg atctgcaatt 773521 cagcatgaga aaagcggaat acaccattga tacatcaagg atgatcgcag aaggcacact 773581 cagcttgtca gagctgccgc atatggcgga tgaagacatt atgaagaaac tgatcaaaat 773641 caggggtatc ggcccgtgga ccgtgcaaaa cgtcctcatg ttcggacttg gccgtcccaa 773701 tttattcccg cttgccgata tcggcctcca gaatgccatc aaacgccact ttcagctgga 773761 cgataagccg gcaaaggatg tcatgctggc gatgagcaag gagtgggagc cttatttaag 773821 ctatgcgtct ttgtatttgt ggaggagtat agaataattc gtctgacaat gaaggaaatc 773881 ctgcaaacgt gttatactag aaagatgtga aaaaaccatt tcactttctg ccatccgcag 773941 aaagcttcat atagaaacgg agagaacaac gtgaaccaac aaaagaaaca ggcgcccgtc 774001 gaactgaagg tcggacaaac ttttccgctg acgattaagc gtctcggcat taacggagaa 774061 ggtgttggct attttaagaa aaaagtcgtc ttcgtgcccg gcgcgcttcc tggcgaagaa 774121 gttgttgtgc aggccacaaa ggtccagccg aagttttcgg agggccgcat taagaaaatc 774181 cgcaaggcat ctgagcaccg ggtggcaccg ccttgccctg tttatgaaca atgcggcggc 774241 tgtcagcttc agcaccttgc atacagccag cagcttcggg aaaaacgtga tatcgtcatt 774301 cagtctcttg aacgccatac gaagtttaaa gttgaaaaca tggaaatcaa agaaacgatt 774361 ggcatggaca acccgtggaa ttaccgcaat aaaagccaat tccagatcgg gcgctcgcaa 774421 agcggcagca tcatcgccgg cttatacggc cttgattctc atgatatcgt gccgattaaa 774481 gactgtatcg ttcagcatcc ggcaacgaac aaaacaacag gcatcgtccg ccgcatttta 774541 gaggacttca atgtgtctgt ttataatgaa agaaaacgaa aaggcgacgt tcgcacgatc 774601 gtgacgagag tcggctttga aacaggcgaa gtgcaggtcg tgcttgtaac cgcaaaagaa 774661 acgcttccgc acaaggaaga aatcgtcaaa gcgattcaaa agcgattgcc agaggtcaaa 774721 tccattattc agaatgtaaa cggggcgaaa acctcagtga tttttggtga gaaaacaaaa 774781 cagctcgccg gaaaaacagt gattcaagaa gtgctcggcg acgtatcttt tgaattgagc 774841 gcccgcgctt tcttccagct caatccggaa cagaccgtca agctgtatga tgaagtgaaa 774901 aaagcggcgc agctgaccgg aaaagaaaaa gtcgttgatg cgtattgcgg cgtcggcact 774961 atcggcatgt gggttgcgga cggagcgaag gaagtccgcg gcatggacgt catcaaggaa 775021 tcaattgacg atgctaagaa aaacgccaaa aaacacggca tggcaaatgc cacatacgta 775081 acaggaacag ccgagcactg gctcccgaaa tggacgaaag aaggcttccg cccggacgtc 775141 gtcattgtag acccgccaag aacgggctgt gacagcacgt tcttggacac gatcaaaaaa 775201 gtcaaaccga aacgctttgt ctacgtttcc tgcaatccat ccacgcttgc gaaagatttg 775261 cagacgctgt cgaaggacta tcgcgtggac tatattcagc ctgtcgatat gtttccgcag 775321 acggcgcatg ttgaagcagt ggcgaggctt gtattaaaat cgtctaacta aaaagaacat 775381 ttcccagtca taaaatagtt ttcctaataa gacctggatt tcggtaaaat aaacaattcc 775441 gatttccggg tctttttcgt gcgcagctct tgtcctaacg gtctgttctc aattttatct 775501 tccttctttt cgcggagatc tttattttaa ctggcgaaaa gaattgaaaa aacgtgttga 775561 aaagcaggtg aaaaaaagcg ttatttaacc ggaaaaatat cctcccagta tgtttaaaat 775621 acatgagtag aatgatgtaa aatcatagat gtattttcat aatttgtaaa attatatatt 775681 gacttgcagt tattacgtgt gaaatattga tgataggaat ataaggaaag tatggcgtat 775741 atcatttcaa gagtcattcg atgtaaaaag ttgaaacatt gtaataaatg aaagaggtga 775801 aaatgatggc caaccccatt ttaaaatgca taacgtatga gcactacaac aattaaataa 775861 tagtgccgag acgataacaa ctattacagt aatacctaca atggttatat ccttgcgaca 775921 atcatgcttc ataatataat gattttagat tgacacttgg ctaaaaagta ttgcagagaa 775981 ggaaatggat aattaaatgg ataaagtata taaaagaagt tggtttcaaa catttttggc 776041 atttttagta tctcagcttt attttaattt tgtagaatta acgggatggg gtcctaagta 776101 tagagaaatg aatggattcc cagcaaacat agttgaacta gatttctttc aaacatatct 776161 ttcattctat gataatccat ggtttaatat tattactgtt ttcttgggag ttttcactat 776221 tatacaaata attacaggga taacaaagga tattcgaaat taaagcaata acttctgatg 776281 ccttatttaa tgatgaaaga aaatgtacac tttcttaatt atcttatgag tgaagactgc 776341 gacacttagt cagcagtcta ttttatggtt ctggatcagg attaccgaat tataacccta 776401 tacaaatata tagtaggttg ccacttgctg cgttggttat tttctaaatc atgagcaaat 776461 cccaaatgat tcagattgaa gttcttgaat tcttttaaat aagggtttat tttctcttct 776521 catcctcttt actccatgtg attcacaagt ggtagcagct taagtaggtt ttttcattct 776581 cttgagtact cagttatacc acccccaact caatttgctt tatctctatt agtttttccg 776641 caaatatgat atagagatac ggatatggtg tagtgttaaa tatcttatct tcaataacag 776701 ggcaattatt ttgcgttggt aatatggaga actcatatga tattctattt aggttggaat 776761 cctttttatc caaaaagttc aaaagcaagg ccactaagaa agacgaaggt cagcgccagt 776821 taaccagaat ataaaaaata gggtagataa tcatcccacg tgaaatcttc aaaatttact 776881 atagattgat aagaaatgct ttcgcatgcg ataagtgtaa aagaagcatg gtcagttttt 776941 aatttgggat aaaggttcag ccgtatccca taatgaaagg atttgatttt tgttatgaca 777001 gaaaatttct ggcgtgaatt accacggccg ttttttgtac tggcaccaat ggaagatgtg 777061 acagatgttg ttttccggca tgtagtaagt gaagcaggca gaccggatgt gttttttaca 777121 gagttcacaa actcagagag ctattgccac ccggatggga aggatagcgt gcgcggccgt 777181 ttgactttta cagaggatga acagccaatt gtggcccata tatggggaga taagcctgaa 777241 aacttccgta aaatgagtat tggcatggca gagttaggat ttaaaggact agatatcaat 777301 atgggctgcc ctgtgcctaa tgtggcgggg aatggaaagg gaagcggcct tatttgccgt 777361 cctgcagttg cggcagaatt aatacaagct gcaaaagcag ggggattgcc tgtaagcgtg 777421 aagacaagac ttggatacac ggatgtggat gaatggcgcg agtggctgac acacattttg 777481 aaacaggata ttgcgaatct ttctattcat ctgcgtacaa gggcagaaat gagcaaagta 777541 gatgcgcatt gggagctcat cccagagatt aagaaacttc gtgacgaggt ggcaccagat 777601 acattgctaa caataaacgg ggatattcct gaccgtcaaa ctggcttgaa acttgctgaa 777661 caatacggcg tcgatggaat tatgataggg cgcggtattt ttacaaatcc tttcgctttt 777721 gaaaaggagc cgaaagagca tagcagcaag gaattgcttg atctcttaag gctgcatctg 777781 gatctccatg atgaatattc aaaagaagaa gcccgtccat acaagcctct tcctcgcttt 777841 ttcaagattt atctccgcgg attccgaggg gcaagtgaat taagaaatca atgcatgaac 777901 acaaagtcaa cagatgaagt gcgtgcattg ctcgacgact ttgagagaaa gtatcttgat 777961 gggatagagt aacagcagtg cttgattcaa aaaaggctaa caaaataaag ggatttttac 778021 acaattcttg actaaaataa acctggattt tcggtaaatc cgggtctttt ttgtacgcag 778081 cttttactca gcctgtcttt tctctaattt attgtaagaa aataatggta tatttagtgg 778141 agatatcata taaaggggga gaggaaaatg aaacggctat gcatcatccc ctgcggcaag 778201 aaaaaaatct gggatgtcca gcctgatgcc gggccggtaa gagcagagga cgcttatctc 778261 agcccgtttc atcaggcgtg cgagcggtat gcaaaaacat ttttcgatga gtgggtgatt 778321 ttgtcggcga agcacgggtt cctccgccct gatgatctcg tttcgggaaa ttacgatgtc 778381 acttttggca ccggtcatcc ggaaatcatg acagcggacg agctgcgccg tcaatttcac 778441 gaaaaaggct tttctgatat cgaagagcta gtcatgcttg gcggaaaaaa atatcgaagc 778501 gttctaaacg ccgtcatcgg agaacaccag catatcagct ggccgctatc atcatacaaa 778561 ggcataggct atatgctcca agcgctgaac cgggctgttg aagaaaagca tgaactgtag 778621 cacgtacata tgaggaaaag agtgggaaca tgaaaaaact tgtgtttggc ttgcttgcca 778681 ttgtgttatt cggatgcgga ctatatatct atcatgtatg gttcggtgat ccattttcga 778741 aaaatgctgc agaacagaag ctagtgtctt atgtgaaaca aacctatcct aagaaagaaa 778801 tcaagatcac gaatggggta tataacgcta aaacgtctga atatgtattt gaagcaacct 778861 cccaatctca tcgctaccca atgtgtacga agggatttct gcatcctaaa gtaacgtgcg 778921 atggaattga agaagcgtat accgaatcag tagcaaaaca tgtaaatgaa gaagcaacga 778981 aggcaatcga agcagatctg aaaaaagcgg ttcctcgatt tataaaagct gatgctgctt 779041 tgagtatcga aaacggacag ttcacgttag atacaaaatg gaacaaaaag ctggctgaaa 779101 aagcgcctat gagcatgacg attcagttag acgccagcgg gttatcaaaa acagatgccg 779161 caaagatggc ggaaacggtc agaaaaacgc ttaatgaaaa gggatataca tactcaaacg 779221 gcacgataga ctgtatgcag aaggacgggg acggcggtat tggatatgtc aaatattcaa 779281 ttgattttct ttcaaaagca gctattcagt caaacgatgc agaggaacta ggaagttaaa 779341 aagatttcca aggaaataaa tacgtcgatc attgtcaaag gccgggtgat atccggtctt 779401 ttttttgcat gctgtaaaac gagacaaatg aatcagtttg agacaaaacg agacacacgt 779461 ctcaaactgt ctccaaagtg aagatgagaa gactgatttt acgggctcaa aagactggca 779521 cacttcttgc atttataatg gtgaacccta aatagaagga ggcgcacaaa atgaaattgt 779581 taaaacgaga aggcttgtca ttaactgagg aaaaagcgct gtggatgtac caaaagatgc 779641 tggagatcag gggctttgaa gacaaagtgc atgaactgtt cgcccaggga gtgcttcccg 779701 gattcgttca tttatatgcc ggtgaggaag ccgtggctgt aggggtgtgc gctcatttac 779761 atgatggcga cagcattaca agcacccaca ggggacatgg acattgtatc gccaaaggct 779821 gtgacctgga cggcatgatg gcggaaattt tcgggaaagc gaccggattg tgcaaaggca 779881 agggcggttc tatgcacatt gcggatcttg ataaaggcat gttaggcgca aatggaatcg 779941 tcgggggcgg ctttacgctc gcatgcggat cagcgctcac ggctaaatat aaacagacta 780001 aaaatgtaag cgtttgcttt ttcggggacg gggcaaataa ccaaggtacc ttccacgaag 780061 ggctgaattt agcggctgta tggaaccttc ctgtcgtatt tgttgctgaa aacaacggct 780121 atggcgaagc taccccattt gagtacgcat cagcctgtga ttcaatcgcc gatcgggcgg 780181 ctgcttataa catgccgggg gttacagttg acggcaaaga tattttagca gtttaccagg 780241 cagccgagga agcgatagaa agagcaagaa acggcggcgg cccgtctttg attgaatgta 780301 tgacctacag aaactacggc catttcgaag gagatgccca aacctataaa acgaaggatg 780361 aaagagttga gcaccttgaa gaaaaagatg ccattcaagg ttttaaaaac taccttttaa 780421 aagaaacaga tgctaataag ctgtcagaca ttgaacagcg tgtcagcgaa tcgattgaaa 780481 aagccgtctc gttcagcgaa gacagcccat atccaaaaga ttcggagctg ctgacagatg 780541 tgtatgtgtc atatgaaaaa ggaggaatgt aagagatggc gagagtcata agcatgtcag 780601 acgcgatcaa tgaagcaatg aagcttgcga tgagaaaaga cgaaaatgtg cttttgatcg 780661 gtgaggatgt cgccggggga gcggcggtcg atcatttgca ggatgatgaa gcatggggcg 780721 gtgtattagg ggtcacaaag ggactcgtac aggaattcgg gcgtacaaga gtgctggaca 780781 ctccgatttc tgaggcaggc tatatgggag cggctatggc tgcggcatca accggtttga 780841 gaccgattgc cgagctgatg tttaacgatt ttatcggcac gtgctttgat caggtgatca 780901 accaaggggc gaaattccgt tatatgttcg gcggaaaagc gcaagtgccg attaccgtcc 780961 gcaccacata cggagcaggg ttccgggccg ctgcccagca ttcacaatcg ctgtatggcc 781021 ttttcacgag catccctgga ctgaagacag ttgttccatc caatccgtat gatgccaaag 781081 gtcttttgct tgcagcaata gaagataatg atccggtgtt tttctttgaa gacaaaacgt 781141 cctacaacat gaagggcgag gtgccggaag attattatac aattcccctc ggaaaagcgg 781201 atatcaaacg cgaaggcaat gatgttacgc tctttgcagt cggcaagcag gtcaatactg 781261 cgcttgaagc ggctgcacag ctttcagaga ggggcatcga agccgaggtc cttgatcccc 781321 gcagtctgtc tcctctggat gaggatgcga ttttcacatc gttagaaaaa acaaaccggc 781381 tgatcatcat tgatgaagcc aatccgcgat gcagcattgc cacggatatt gctgcgcttg 781441 tcgctgacaa gggctttgat ttgcttgatg cgccgattaa acggattaca gcgccgcata 781501 caccggttcc gttttcacca gtgcttgaag atcaatattt gccgacacca gataaaattg 781561 tcagcgtcac gcttgaattg cttggcgagc cggcattgaa ttaaaggggg gacacaaatg 781621 gcggtaaaag tagtgatgcc aaaattggga atggccatga aacaagggga agtatcgata 781681 tggaataaaa aagtaggcga cccggttgaa aagggagaaa gcattgccag cattcaatcg 781741 gagaaaattg aaatggagat cgaagcgcct gaaaaaggaa cgctgatcga tatcaaagtg 781801 aaagagggag aagaggttcc gcccggcaca gctatctgct atatcgggga cgccaatgag 781861 tcggtgcagg aagaggcggg ggcgcctgtt gctgaagaca atatgccgca agccgtccag 781921 cccgtcaaac aagaaaacaa acccgcagcc tccaaaaaag atcgaatgaa aatatctcca 781981 gtcgccagga aaatagcaga aaaagcagga ttagacctaa aacaactgaa aggaactgga 782041 ccaggcggac gaatcgtgaa ggatgacgta acaaaggctc ttgctgaaca gaaaaaagat 782101 caagcaaagc ctgtttcgga gcagaaagcg caggaaatcc cggtgacagg catgagaaag 782161 gtcatcgctg cccgaatgca ggaaagcctg gcaaacagcg cgcagctgac gatcacgatg 782221 aaagctgata tcaccaagct tgccactctt caaaaacagc tttcaccaac tgcggaagag 782281 agatacggca caaaactgac gatcactcat tttgtctcaa gagccgccgt tctcgctctg 782341 caagctcacc ctgtgctgaa cagcttttat caaaatgagc gcatcatcac acatccccat 782401 gtgcaccttg gtatggctgt agccttggaa aatggcttag tggtgcctgt catccgccat 782461 gctgaaaagc tatcgctgat tgaactggct caatccatct cagaaaatgc caaaaaagca 782521 cgcgagggac gtgcgggaag cgaagaactg caaggatcta ctttctccat tacaaacctt 782581 ggcgcgtttg gagttgagca tttcacaccg atactaaatc cgccggaaac aggcattctc 782641 ggcatcggag caagctatga cacaccggtg tatcaagggg aggagatcgt cagaagcacg 782701 atcctgccac tcagcctgac atttgatcac agagcgtgtg acggcgcccc tgccgctgca 782761 ttcctgaagg cgatgaaaac atatttggaa gaacccgcag cattaatttt ataggaaaag 782821 caggtgaaaa cgacatgaca ttagccatta tcggcggcgg acctgcaggc tatgcggctg 782881 cggtttccgc ggcacagcag ggcagaaacg tgctgctcat tgacaaaggc aagcttgggg 782941 ggacctgcct gaatgaaggc tgcatcccga caaagtcttt gttagaaagc gcaaacgttc 783001 ttgataaaat caagcatgcc gacagctttg gaatcgaact tccggcaggt gcgatatcag 783061 tcgattggag taaaatgcaa agccgaaaac aacaggttgt cagtcagctt gtccaaggcg 783121 ttcagtacct aatgaagaaa aatcaaatac aggttgtaaa gggaacagcc tcctttcttt 783181 ctgaaagaaa gctcttgatc gaaggagaaa acggaaaaga aatcagagag gcggaccaag 783241 tattgattgc ctccgggtca gagccaatcg agctgccttt tgccccattt gacggcgaat 783301 ggatcctcga cagcaaagac gcgctttctc tttccgagat tccgtcttca ctagtcattg 783361 tcggcggcgg tgtcatcggg tgtgagtatg cagggctgtt cgccagattg ggatcgcagg 783421 tgaccatcat tgaaacagcg gaccggctga tcccggctga agatgaagat attgcccgtc 783481 tctttcagga gaaacttgag gaagacggtg tcgaagtgca tacttcatcc agattagggc 783541 gggtggatca aacggccaaa acggcaatat ggaaaagcgg tcagcgagag tttaaaacga 783601 aggccgatta tgtgctggtg gcgatcggca gaaaaccccg tcttgacgga ttgcagctgg 783661 aacaggccgg agttgatttt tctccaaagg gcattccggt gaatgggcac atgcagacga 783721 acgtgcctca tatttacgcg tgcggagatg ctataggggg cattcagctc gcgcatgccg 783781 ctttccatga gggcatcatc gctgcttctc atgcttccgg aagggatgtc aaaatcaatg 783841 agaaacatgt gccgcgctgc atctatacgt ccccggaaat cgcgtgtatc ggaatgacag 783901 aacgacaggc aagaagcata tacggggatg tgaagatcgg cgaattttca ttttccgcaa 783961 acggcaaggc gctcattaaa cagcaagcgg aaggaaaggt caaaatcatg gctgaaccgg 784021 aattcggcga aatcgtgggt gtctcgatga ttggcccgga tgtaaccgag ctcatcggcc 784081 aagcggcagc gatcatgaat ggtgagatga cggcagatat ggcggagcat tttatcgccg 784141 cccatccgac tttatcggaa acattgcatg aggcgctgtt aagcacgatc ggccttgcgg 784201 tacatgcata ataaaggaaa aagcaggcgc atggatataa ggcgcctgct tttttattgt 784261 tgaaagcgct ttatttttcc cctacaatag atgaaaacgg cgtgtaaggg aggagcgatc 784321 aaggaaatga attcggtccc aaacgatttg caaacctgga aacgttttgt gaaagacggt 784381 gtgcttgacg aagcccgatt aagaaaacgg attgcagagt catggcatcg ctgcaaaaaa 784441 gctgaggtca atccttattt agaaaaaggc ccgaaggttt tacagcaaac ggagctggat 784501 cagcagtcaa aaaaacattc attcttcttg acgaccgcaa agccttacct cgaaaaactg 784561 ctgcctgcca taaaagaaat ggaaatgatg gcgctgttaa ttgattcaga cggtgttgtt 784621 ctggcattgg acggccatcc gcgcgcgctc tatgaagcca aacgcatcaa tttcgtcgaa 784681 ggggcatgct ggacagaaac ggctgtcgga acaaatgcga ttggcacggc gctccacatc 784741 agcgagccgg ttgcaataca aggatcagag cattactcta tcgcttccca tctttggaac 784801 tgttcagctg ctccgattca ccatgaggat ggcagccttg cgggtgtaat tgacatatca 784861 tgcccggcgg caggcgcgca tcctcatatg cttggtattg ccacggcgat tgcctatgcc 784921 gctgaacggg aactcgcagc taaaagccgt gagaaagagc tggagctgat cagccgtttt 784981 ggggagagag ctgcatccag tgtgccgatg gtgctctgta ataccaagca gcacatcatc 785041 agtgcgagca tgccgattcg aacctcaatg ccggattggc agggccggca cctgtacgag 785101 ttgaaggaac ggggctattc aatcgaaaat gctgtcacca taggagatgg cggcacttgt 785161 ttttatcttt cggaacaaaa gaaaaagaag gcgtttcgat tcaatggagt gatcgggcaa 785221 agcggccgat cgcaagcgat gctgatgcac cttgaacgag cagctgcgac ggatgcatcg 785281 gtctgtttgt cgggtgaaac gggtacgggg aaggaggtcg cggctcgcgc gcttcatgag 785341 aacagtgaga gacggcacgg tccgtttgtt gctgtcaatt gcggagcgat tccgtctgat 785401 ttgattgaaa gcgaactgtt cggatatgca gagggcgctt ttacgggagc gaaacgaaat 785461 ggctataaag gcgcctttca aaaagcgaat caaggcacat tatttttaga tgaaatcgga 785521 gaaatttccc actcgatgca ggttgcactt ttacgggtgc ttcaggaacg caagataacg 785581 ccaatcggcg ggacgaaaga aattccggtt gatatcagag ttattgccgc cacacattgt 785641 gatttacgcg agcttgccga aaacggaaaa atcagagagg acttgtttta ccgtcttcat 785701 gtctatccaa ttgaactccc tccattacgc gatcgcaccg aggatatccc ggatctcttt 785761 gagtactaca aacagaagaa tcattggcca ggcgatcttc cttctgattt ttgtaatgtg 785821 ctgaagcaat ggaagtggcc ggggaatatc cgcgagctgt ttaatgtgtt tgaacgtctt 785881 tctatcagat ttccggacgg ccggctgaga gatgaatcgc ttcccgcttt actggaagcc 785941 gctggattgc cggccagctc tgcagaaaaa aagccggctg ctgccggcgt gcttactttt 786001 cgtgagcaaa tccaaaagga tatgatgatc aaagcgcttg aatctgcaaa aggaaacgtc 786061 tctcaagccg caaaaatcag cgggatcccc cgaagcactt tctacaaacg cctgaaaaaa 786121 ttcaacttgt ccgctgaatc ataaagcata cttccttcag gaaatggaaa cgttatgtat 786181 tgaaggaggg tgttacgatg aatattcaaa gggcgaaaga aattgtagaa tctcccgaca 786241 tgaagaaagt aacatataac ggcgttccta tttacattca gcacgtaaat gaagaaactg 786301 gaacagcaag aatttatccg cttgacgaac cgcaagagga gcatgaagtg cagctgaaca 786361 gcttaaaaga ggattaaaca aaaatggccc gcttcataag caggccattt tgttatccgc 786421 gcggcgcaaa taaaataaca cagacaccga tgagacaaat gaatgcgccg atccagtcat 786481 acagatcagg tgttttccgg tcaacaagcc atccccacag gaccgcaagc acgatgaata 786541 ctccgccata agcggcgtat acacggccga aagatgggaa ggactgaaac gtcggaagaa 786601 tgccgtatac aatgaggatc agcgccccgg cgattccgta gccagctggc tttgcctctc 786661 tcagccatag ccaaaccaga tatccgccgc caatttcagc aagccctgcc gcgagaaata 786721 aaagaatggt aatcagcatc atgagcactc ctcaatttgc atttatcttt cattatagag 786781 gaggagagct tttaaagctt cggatgattc tcaaattcct tcaaatacgc ttttcgctga 786841 acctctgtaa attggctgat ccaattgttt tgagcctctt cattcaaatg gggaaggata 786901 tagcgttcaa ccgcttcgaa aaacagcgga ttcgtgatga tgttccaggt cgggattcga 786961 acgattttgc cgtctgtttt ctcgatgata atatcctcaa aaaagatccc tttcaaactg 787021 tattgatggc gtcccatata aagccgcttc acctcggaaa acagcacgct gcgctttctc 787081 aagaagattt cgccactagg tccggtcttt atggtgaaaa tgacatttcc acggcttgtg 787141 aacgcaggaa aagccataaa gaatgtgatc aatccataaa tcatcgccag taatccgccg 787201 cccaaataaa gcagggcata tttagattca aacgtgaggg cttcagacac cagccagact 787261 cccacaataa aggcgccccc tgtagcgagg aacagccaag cccttagaaa catcatgctt 787321 tttacttcaa tcatgtgctg cccctaaagc ttcggatgat tctcaaattc cttcaaatac 787381 gcactgcgtt ggatgtctgt aaactgtccg atccaattgc ttttcgcctc ttcattcaga 787441 tgtggaagga tatagcgttc aaccgcttcg aaaaacaacg gattcggaat gatgttccaa 787501 gtgggaatgc gaatggtctt ctgatccacg gtttggatca atatatcttc ttggaagatt 787561 ccttttagac taaatttatg gcggctcatc tcaattttct tgatatcagt aaacgtaaca 787621 gacactttgt cagtgaacac ttctccattt tttcctgtct tgatgcggaa aatggtattt 787681 ccccgcgggg tgaaagccgg aaagaagatg ataaataaat ataaacaaaa caaggtgaac 787741 agaaagccag caggaatggc taataggtaa tatttcgttt gaaacgtaat acccatataa 787801 aagagccaca aacatgctaa tcccataccg gcagatccga caaaagccca tattctcagg 787861 aacattttgc ttttgacttc aatgatttct tggtttttca atgcttttct ccttttgtta 787921 attcaattct tatcattttg aaatgatttg atttacaaca tccttatgag cagggaggat 787981 agaaaattca ttctgggtga tgcctgtgac aagccaagta tggtgggccc ccggcaggac 788041 gaatgccatg tcagccactt caggagtgtt atcttttcca tatgccagac gcataagtgt 788101 atccattttc cctttccgca aagccagatc atttgcaaat cgggtaacgt cctcttggtg 788161 gtcatgtttt tcaaggaact cttttagata tgaagggttg tctgaagcgc cctccaagag 788221 tttttcaaat tcatttgatg tcaatgttac aatcgattct cttttatcct ctgtatctat 788281 tatatgtaaa aactcatctg tcttagcaag taacccttca cttgattcca tttttgtaat 788341 gcgatggact tgttcatcaa aaaggagttc gtgagagtag gtgccgaatt ttgatacatg 788401 gcatgacaca ttctgttcgg caccttgccc gttaaattta gaaagcttca ctgtatagtc 788461 agcgtcgttt aatacatgga taaacggaca gtactcgtcc tttaaccgat attgatggtt 788521 ccgatattcc gctgcatcct tggctaagag tgagcggcac gcggcttcaa ataaggcgcc 788581 gagctgttca tcttctattt ccggaaaata ggcctgcttc aaggccattc cctgttcaaa 788641 aaacccttcg ctgtaaaagc aaaacaagag ttcttctatg ctaattgtaa actgcttcat 788701 tgtttattct cctatccaaa tgaaaatttc cctttaagga aatgggttgc gccgtgtata 788761 agcgaatccg ctgttttctt tgctttttcc attccttttt tcgcgctgtc tatcccttta 788821 tgtatcgatt tattcgccgc atctatgccg tcattcactg atttgacgac tttgccggct 788881 gattccagcc cttttttggc tgtatcaaca acagcatgga tcggttcttt cagctttaag 788941 gctgcttttt cagcaaaacc ggctgtatat ttggcgattt gttctccgac gactccgcca 789001 atgtatgaac ctgctgcccc aagaaggaca gtacccacag gtcctgcaaa gcttccgatt 789061 gcaccgccga tgacagcacc agctgtggca ccgccggcaa caaaaatcgt attattcaca 789121 gcattcccga cggccttggc gttttcacgc ttgagaactt ccggtttatc ctggtatttt 789181 gcataatttt cagcaatttt cacgcctgct ccgaatgttt cggtcgctcc ggtaatcagt 789241 gtggcggtaa tggcatttcc tttcgcgaat ctcaagcccg tttttcccac atccttcaaa 789301 gtggagcgta cgccggcttc attaagaaat ccttttgtgt agcttctgac gctgtttgaa 789361 aaatccaccg tgtcctgagg aaagtatttt gtaaactttt tatgtaccaa atctgaaaat 789421 ggacggtttg tctttttcaa caaatattta ggattcaaaa gcactcttgc cgctttttga 789481 taacgtgagc tgtcaacggc cctggaaata tccaagagca gttttgagtg ctgggctgta 789541 tgcaagccgc ttggttgttt cacaaatttc gtaagcccta atccgtaata ttttccctgc 789601 gtcagcataa gagcggttaa gcttgtcatc gtaccgtatt tgtcgtaggc attgtagagc 789661 tttcgcaaaa tatcatcttg ttccacaaat ttatcgcctg tttttctgat gaaaatctca 789721 ttgtcactca gcttagtgac gagcgccttt cctgagctcc acgcatcgcc cactccagaa 789781 aaacagctgc tgtagcgggg atcgcattgc aaaatcatct gccccagctc cacatgcagg 789841 tccttatatt tgttttccat atcagttaat tcagtgacta catcatttgc aagctgttcg 789901 agcttatccg gatcaactgc aatgtttcct gacacaccgt tcacctcccg agtttatgtc 789961 tttcctctct tgctttacgc tccagttctt ccattctggc aatttcagct tttcgttctt 790021 ctattttgac agcggcagcc ttcagctctt ggcttgtttc aagcagctcc tgttcgaatt 790081 gatcgtaggc ggctttcgtt tcctcgaaat cctggtcaaa cgaatctctt gctttgccct 790141 gccaagcatc tcccaatgca gataaccggg attcaagcag cattttggag cttctgacct 790201 cttctgcggc cgcactatac ttgtttgcca gctcaatgac tttatatgag tccaactttt 790261 gtcccctgcc ttttctaaat tcacgcacaa ttggatgttt tatataaatg attataaata 790321 attcggcatg tatccgaatc gtacaaaaga accttttcat aagaattgga agggcgtata 790381 ttcacttaaa attcacagtt ggtgagactt taagattaca aaaaaggtaa aaaaaccaaa 790441 tctctcagac ataaggcaaa tgagaaattt cccgctctat gggaaaaaac actaaagttg 790501 atcaaatgac ctaagtgcgc caaacgtgtt acgggacgag ctatctcatg gtataaatgg 790561 aattgtaaac gttatcaagg aggtcgtcat atgaagaaaa aatcattctc aatcgtaata 790621 gcgggcggag ggagcacttt cactccaggg atcgtactca tgctcttgga ccatttggag 790681 gagtttccga tcagaaagct gaagctgtat gataatgata aggagagaca ggatcgaatt 790741 gcaggcgcct gtgacgtttt tatcagagaa aaagcgccgg atattgaatt tgcagcgacg 790801 actgacccgg aagaagcttt tacagatgtc gattttgtta tggcgcacat cagagtaggg 790861 aaatacgcga tgcgcgcgct tgatgagcaa attccgttaa agtacggagt tgtcggccag 790921 gagacgtgcg ggccgggcgg gatcgcatac ggtatgcgtt cgatcggcgg tgtgcttgaa 790981 atattagatt acatggaaaa atactcgcct gatgcgtgga tgctcaatta ttccaatccg 791041 gcggcaattg tggctgaagc tacgagacgc cttagaccga attctaaaat tctcaatatc 791101 tgtgatatgc cggttgggat cgaagaccgg atggcgcaaa ttcttggctt atcctcaaga 791161 aaagaaatga aggtccgcta ttacggattg aatcatttcg gctggtggac atcgattcag 791221 gatcaagagg gcaacgattt aatgccgaag ctgaaggaac atgtatccca atacggttat 791281 attccgaaaa cagaggctga agctgtggag gcaagctgga atgacacgtt cgccaaagcg 791341 cgtgacgtgc aggctgcaga tcctgacaca ctgccgaata cgtatttgca atattatttg 791401 ttcccagatg atatggtgaa aaaatcaaat ccgaatcata cgcgggcgaa tgaagtcatg 791461 gaagggcgcg aagcttttat tttcagccaa tgtgacatga tcacacgtga acagtcctcg 791521 gaaaacagcg aaattaaaat cgatgaccac gcatcgtata tcgttgatct tgcccgggcg 791581 attgcctaca acacaggtga aagaatgctg ttgattgttg aaaataacgg tgcaattgcg 791641 aactttgacc cgactgcgat ggttgaggtg ccatgcatcg tcggctcaaa tggacctgaa 791701 ccgattaccg ttggcaccat tccgcaattc cagaaagggc tcatggagca gcaggtatcc 791761 gttgagaagc tgactgttga agcgtgggca gagaaatcgt tccaaaagct gtggcaggcg 791821 ctgatcctgt caaaaacagt gccgaacgcg cgtgtggcaa gactcattct tgaggattta 791881 gtggaggcca acaaagactt ctggcctgag cttgatcaaa gcccaacccg catatcataa 791941 atgaaattcc cccattttcg aatctgtaat tgtatataat agaaagaaaa tggggggatc 792001 tgatatgcag ctcgaagaac tgatcaatca gcactacagc aaattgaatg acaacgattt 792061 tcatatttta aaatatatat tgaatcataa gcacacatgc tatcaccttg gaatcgacgc 792121 gctggccaaa gcttgcagtg tatcgcgttc ctcaatttta cggcttgccc aaaagctcgg 792181 tttcagcggt tacagtgaat ttcgcgtctt tttaaagtgg gaagatcagc cggaagaagg 792241 cgagagtatg agttttgaaa agctgcttga tgatattgaa gcaaatttga agtttttacg 792301 gacaaaggac atgacggaca tgtgccagct gattgatgca gctgaccgca ttttcgtcta 792361 cggttctgga aatgcgcaaa agatatgcgc ccgcgacctg caaagaatgt ttattccgcg 792421 ccatcgctat cttattttga ttgaagacac aaatgaattt aatttgatgc gcgatgattt 792481 taaagtgaac gatctgttta tcatcatttc tctttccgga gaaacaccgg agctgattcc 792541 tcaggcaaga atgctttctg caaagggtat tccctttatt tccattacga atttaaaaaa 792601 caatgtcctc gcccagctga ctccgcataa tctttatgcg acaagcaaac ctgtgacatt 792661 aagcgataga acggaaattg tcgcttttgc accgtttttt ctcgttggcg aagcattgtt 792721 ccgcgcatat gttgattaca aagaggcaga aaaaaatgac aatgagtagc agggggttct 792781 ggtatgatgc aaaaaattca gcgctttgga agcgcgatgt ttgtgcctgt tttattattc 792841 gcgttcgccg gcattatcgt cggtatcagc acgctcttta aaaataaaac cctcatggga 792901 ccgctcgccg atcctgacgg tttttggtat cagtgctggt atatcattga gcagggcggc 792961 tggactgttt ttaaccaaat gccgctctta ttcgccattg gcatcccggt tgctttggcg 793021 aagaaagctc aggcacgcgc ctgtttggaa gcgcttactg tctacctgac attcaactat 793081 tttgtcagcg cgatattgac ggtatgggga ggagcatttg gcgtcgacat gaatcaagag 793141 gtcggcggaa cgagcgggtt aacgatgatt gcgggcataa aaacgctcga taccaacatc 793201 atcggagcca tctttatttc ttcgattgtc gtctttttgc ataatcgcta ttttgataaa 793261 aaactgcccg attttctcgg catctttcaa ggctcaacat atatcgtgat gatttccttc 793321 tttattatga tcccaattgc gttggctgtg tcttatattt ggccgatggt tcaatcggga 793381 atcggctcgc ttcaaagctt cctggttgct tctggggcgg tgggcgtttg gatatacacg 793441 tttttggaac ggattttaat tccgaccggc cttcatcact ttatttacac gccgtttatt 793501 tatggcccgg ctgtagcgga aggcgggatc gtcacgtatt gggcacagca tctcggcgaa 793561 tattcgcaaa gcgccaaacc gctgaaggag ctctttccgc aaggcggatt cgcgcttcac 793621 ggcaactcga aaatcttcgg tattccgggt atcgccctgg ctttttatgt gacagccaaa 793681 aaggaaaaga aaaaactcgt cgcagggctg ctgattcctg tcacactgac agcgattgtc 793741 gccggtatta cagagccgat tgagtttacg ttcttattca tttcaccttt cttatttgcg 793801 gttcacgccg tgcttgccgc cacaatgtcg acagttatgt atatggccgg cgtcgtcgga 793861 aatatgggag gcggactgat tgaggcggta accttgaact ggattccgct ctttggcagc 793921 cacggtatga catatgtgta tcaaattttg atcgggctct cgtttacagc aatttatttt 793981 ttcgtcttca gatttttaat cctcaaattc aatatcgcta caccaggacg ggaaaaggat 794041 gaacagcagg aaacaaagct atattcgaaa aaggaataca gagaacgaaa aaacaaggat 794101 gaaacggcct ccgctgctga aacggctgat gacaccgctt ttctgtatat tgaagcgctg 794161 ggcggaaaag acaacatcac tgaagtcaca aactgcgcca cccgcctcag agtcagtgtc 794221 aaggatgaaa caaaggttga acccgacagc gtattccgcg cgcttggcgc acacggcgtt 794281 gtcaggaacg ggaaggcgtt tcaggtaatt atcggattaa gcgtgccgca gatgcgggag 794341 cgtgtggaaa aaatattgaa tcaataaaga ctgccctcct tttcgggagg gttttcgttt 794401 gccgtcaaaa agaccgccat agtaaagtaa agaaagagac aatcgagtaa aaaggggttt 794461 ggaggctttt acatgcaaaa ggctttgtcg tttttaaaac catattcatt gctggcggga 794521 attgctctga ttcttatgct gacggagctt gcagttgaac tgatgcagcc tttattgatt 794581 gcaaaaatca tcgacgatgg gatattgaag caagatctgc ggcatgtatg gatatggggc 794641 acggtcatga tcgggctgac cgtgttatcc tttgcggcgg ggatgctgaa ttccttttat 794701 gccgcccatg tcagccaaag cttttcctat gatacgagaa aagggctttt tcaaaaaatc 794761 cagtccttct cctattccac atttggacag ttttcgtcct cttcttatat tacaaggctg 794821 acaaacgacg tcacacaggt tcaaaatatg atttttatga gtttgcggtt tatgctgcgg 794881 gctcccttaa tgattgcagg cggcattgtg ctgtcgcttg ccgttaatgt gaaactcggg 794941 ttttttctgc ttgtgaccat tccgatcctg atcttgtttt tgctatgggt attaaggaaa 795001 ggcggggcac tgttccgctc agtgcagaaa aggctggatc aagtgaacac catcatgcag 795061 gaaaatttaa ttgcaatcaa gctgatcaaa gcgctgcttc gcggcagcca cgaagtcaaa 795121 cgatttatca aagccaacac aaggctgatg gaaaaaacgg tttcggcctt tcagcttgtg 795181 gaattcacga tgcctgtact gatgctgctg atgaatctct gcatcctttt gattttgtgg 795241 gcggggtcct acagtattac gagcggaagc actcaggttg gcgatgttgt tgcgataatt 795301 aactacgcaa cacgaattac aggcgcgctt tcgatgtttc cgtttttgat tatgattttc 795361 acccgggcga aggcttcagg ggatagaatc ggtgaggtgc ttgaaacaga aggcgacgag 795421 cgggaggaag gcaccatatc tgatcgtttg tcaggacgga ttgagtttca gcatgtatcc 795481 tttcgctatc ctgaaatgga cagagaagcg ctcaggaatg tctcattttc cgcaaagcca 795541 agagaaacga tcgcgattct cggtgcgacg ggctcgggca agtccacgct ttttcagctc 795601 attccgcggc tttatcagcc ggattcaggc cgcatttaca tagatgaaaa gccggttcaa 795661 gatattccgg ctgaagggct gcgcaggcaa attggatatg taccgcagga agtcctcttg 795721 ttttccggca caatcaaaga aaacatcgct tggggcaaag aaaatgcttc actagatgaa 795781 ataatggatg cggcaaaact tgcgcaaatt catgaaacga ttttaaagct cccaaatgga 795841 tatgacactg ttttggggca aagaggcgtc aacctgtccg gcggccaaaa gcagcggatt 795901 tccattgcgc gggcgctgat tcgaaaaccg gctatccttc tattagatga cagcacaagc 795961 gcgcttgatc tgcaaacgga ggcgaagctg cttgaagcaa tcagcacata ccattgcaca 796021 actttgatca ttacacaaaa aataaccacg gcgatgaaag ctgatcagat tttgctgctt 796081 gaggacggcg aactgattga aaaaggcact cacagtgagc tgctttctga atctcagtta 796141 tacaagcgca tttacgagtc acaattcgga agggagggga gcgagtcatg ctaaaagaca 796201 tccgcaagcc tttccaatat cccaaactgc caattgacaa aaaagaaggc gcgaaaaagc 796261 gggcgaaagc aaaggataca aagggcacac tgagacgaat ctggtcttac ttggctgaaa 796321 gaaaaggact gctcatactt gtcatgctaa tggttgtcat cagcgccata ttcggactcc 796381 ttggtccctt tgtgatcgga aaggccatcg accattttat cgtcgggaaa acggtcagcg 796441 gcttgattcc tgttttgctt cttctgctcg ctatctatat cattcagtcc ctgtcgcttt 796501 ggtttcaaaa ctattggatg attacgatct cgcagggcac ggttttcaga atgagaagcg 796561 aattgttcac ccatctgcat gagctgccga ttccattttt tgataaacag cggcacggcg 796621 agctgatgag ccgggtgacg aatgacatcg aaaatgtcag ttctacctta aacacgtcag 796681 tcattcaaat tttgtcaagt gtgatcacct ttgtcgggac gattgcggtg atgctgtaca 796741 tgagcccgct ccttactttg attacgctga ccattattcc ggtgatggca gcgagcctga 796801 aatggatcac caaccgaacg ggaaagctgt ttaaagaaca gcagaaaaac cttggtgatc 796861 tgaatgggta tattgaggaa tctgtttcag gcgcaaaggt catcaaagca tattcacgtg 796921 agaagcagat tactgctgaa ttcctcgaaa aaaacgctgc actcaagacg tcgggctttt 796981 gggcgcagac gatttccggg tttattccga aggtcatgaa ctctttgaat aacttaagct 797041 ttacaatgat tgcggcaatc ggcggtttgt ttgcgctgaa aggctggatc tcgatcggct 797101 ccatcgttgt ctttgccgag tattcaagac aatttacacg ccctttaaac gatctggcca 797161 accagtttaa tacgatgctg tccgcaatcg ccggcgctga acgggtgttt gacgtgcttg 797221 atgaaaaaga agagcgcgag gatgaaaaga acgccgtgca tcagcccatc caaacaggca 797281 gcattgaatt ccgggatgtg tccttcggtt acgataaagg gcagcagaca ctgaagcatt 797341 tacagtttac cgtgcctgcg gggcagtcca tcgcgtttgt aggaccgacg ggggcgggga 797401 agacaaccgt cactaacctt ctcgcccgtt tttacgagcc taacgatgga aaaattttaa 797461 tcgatggtac agatattaaa acccttacta gagcaagcct aagaaaaaac atggggtttg 797521 ttcttcagga ttctttctta tttcagggaa cgatcagaga aaacattcgc tacggcaggc 797581 ttgatgcttc tgatcaggaa gtcgaagccg ctgcaaaaac agcgaatgcc catagtttta 797641 ttgaaaggct gccaaaaggg tatgacaccg tactgacgca aaacggttcg ggcatcagtc 797701 aagggcagaa gcagttgatt tctatagcga gggcggtgct tgccgatccg gttcttctca 797761 ttttggatga agcgacaagc aacattgata ccgttacaga agtcaacatt caagaagcgc 797821 tcgcccgttt aatggaagga agaacaagcg tcatcattgc ccacaggctg aacaccattc 797881 aaagagcgga ccagattgtg gtgctaaaaa acggtgaaat gattgaaaaa ggcagccatg 797941 acgagctgat tcggcaaaaa ggattttaca gtgacttata tgaaagccaa tttgagaaat 798001 agacctttgt cctgcacaga ggtctttttt tgttacagtt ttatagtact tttatttcat 798061 tttcgtaaaa tgtaacaaaa ttacttgacg taaacaagtt atgtatatat actagcttac 798121 attaagtaag tgataacatt tatcaaggag gataaaatga ataaatcatt tgaaattggc 798181 acattacttt taagagttat tacaggtatt atcttttttg ttcacggttt atcaaagttt 798241 cagggaatgg agggcaccat ccaatttttc ggcagcatag gccttccaag ctttatggcg 798301 tatgtcatcg cagcgattga actgattggc ggagtgcttg tcttcttcgg attggctaca 798361 cgtattgtcg gtgtactgtt cgctcttaca ctgatcggcg ccatcatcac tgttaagctg 798421 aaagcgccat tcatgggcaa tgcagaattt gattaccttc tgcttttgac atccattcac 798481 ctggcgctta ctggaagtcg attcctggcg ctggacccat ttgtgtttaa aggaaaaaag 798541 aacggaaacg tttcagcata agaaaagagg catgcagcat gaccagcatt catgaggata 798601 cacacattgg ctatgccaaa ctcacaattc gcagtctgga gcgttcgctt cagttctact 798661 gtaacgtcat cggttttcaa gtcttaaaaa agacggaccg ccaagcggaa ttaacggctg 798721 acgggaaacg cgtactgctt attcttgaag aaaatccgag cgctgtcgtc ttgcctgaac 798781 ggtctgtgac aggcctttat cactttgcga ttcttcttcc ggacaggaaa gaacttggga 798841 tcgcgctcgc ccgcctgatt gaacacggca ttgctatcgg acatggagac catgctgtca 798901 gcgaagcgct ctacctgtct gatcctgacg gaaacggcat tgaaatgtac gctgaccgcc 798961 cccgcagcac gtggcagcgt gatcgggaag gaaactacgt catgacgaca accgctgttg 799021 acattgaggg ccttctggaa gaggcaggag atgagcggaa aacatcgctt ccgaacgata 799081 caatcatcgg acacattcat ctgcatgtca gtgatttgaa agaagcaaag gcgttttata 799141 cagatgtact gggctttgac attgtcggaa actatgcggg catgtccgcc ctcttcgttt 799201 cagccggggg gtaccaccat catatcggct taaacatttg ggcgggaaga aatgcgccgc 799261 ctaaaccgac aaatgccagc ggactagatt attatactgt tgtcctgccc caccaagagg 799321 agctggattt ggtggcaaac cgagtcaaac atgccgggta ttcgattgaa gagacggaaa 799381 acagctttcg tgtgaaagac cctgtttccg gcgcctatat tacatttgtg atttaactgc 799441 aatccccttg ccgaaataac ggcaggggga ttttttattt ttgtccgcct tgttatgatg 799501 agagaaccaa cttgttagga ggcgtttaca tggaactcaa ccaccttgtg acgggcaaaa 799561 tagcattaaa tcaatatgtg catcgcttag agcaaaagga tgtttcattt tacgtccact 799621 actggggagc gatgacgaac cactataaca cactgcttca taagcattcc ttttatgaaa 799681 tttgttacgt ggtaagaggt gaaggatatt accttgaagg cgatcgtaca tatccgcttc 799741 gtgaacagac gatttttttg tcaaagccgg agcatttgca ccaaatcaaa agtgaaacag 799801 ggctgttcct tttttacgtc gctttcgagc tgagcgagga tcagtcaagc gccgaatgga 799861 tcaaagtgat ggaagaagtg aaacaaagcc cctttatcac aatgcaattg aaagatggcg 799921 aaccgccggg cctgctttgg aaaacgttaa tgctgcaagc agcgcaacct gtcaatgctt 799981 ttgacaaaga gatcctatct catttgtcgc atgcattgat cctgtcatta atccaaacct 800041 ttctcccgta cgcccaacgc ccgaaacaaa agcagcccat tcacacatct tctgctttgc 800101 tgacagaggt gaaactgcac ataaaagaca atctgtcaca gccgttaaag ctgacggatg 800161 tcgctagcca ctttcatatc tcagggaggc atttatcacg tttatttgca gcagaactgg 800221 gcgtcagcta ctcagaattt gtccaaaatg aaaaaataaa caaagctgcc gaactgctga 800281 aatcaacgaa tttgtcgatt aaagaaatag cggaagaaat cggtttctca gtacattatt 800341 tcactcgcgt cttttccgct aaaatcggca gctctccagg gcttttccgc tccctttata 800401 aagactcaaa aatgaccgca tttcaaatca ataaaccttt tcaaaaaatc gaacaggcca 800461 agccgcacga ataagatgtc ctgaaatgac aaaacaatgt cttcatatga taaagacgcg 800521 agaaatctcg ttgtcttata atctttttag aaagcggtta caacaagggg tattgctgaa 800581 ggagggatgc attggcttat gcttggtgtc gggtgctctg ccattcttga aagaagggga 800641 agaaagccgt gagtacaaaa aagaaagagg ctgtaatagg aaaagaaagc ttagctcata 800701 aagggctttt acgaacgatt acattggtat ctacattcgg cggcctgttg ttcggttatg 800761 atacgggtgt cattaatggg gcacttcctt ttatggcaac tgcaggtcag ctgaatctta 800821 cacctgttac agaaggactg gttgcgagtt ccctgcttct cggggcagcc ttcggggcga 800881 tgtttggagg acgtctgtcc gatcggcacg gccgccgaaa aacgatcctt tatttagcct 800941 tactcttcat cgcagccaca cttggctgta ccttttcacc aaacgcgtcc gtgatgattg 801001 cctttcgttt tctgcttgga ctggcggttg gctgcgcttc tgtaacggtt ccaacctttt 801061 tagcggaaat ttcgccggca gaacgcaggg gacgaatcgt gacacaaaat gaactgatga 801121 tcgtaattgg ccagcttctg gcatacacct ttaacgccat tattggcagc acaatggggg 801181 agagcgcaaa tgtatggcgg tatatgctgg tcatcgcgac acttccggct gttgtgttat 801241 ggttcggaat gctcatcgtg cctgaaagcc cgcgctggct ggcagctaaa ggcagaatgg 801301 gtgacgccct gcgggtgctt cggcaaatcc gtgaagacag tcaggcacag caggaaataa 801361 aagaaatcaa acatgcgatt gagggcacag caaaaaaggc cggctttcat gattttcaag 801421 agccgtggat aaggcgcatt ctattcattg ggattggaat cgccatcgta cagcaaatta 801481 ccggtgtcaa ttcgattatg tactatggga cagaaattct gagagaagcc ggttttcaaa 801541 cagaagctgc attaatcggc aatattgcaa acggtgttat ttcagttatt gcggtcattt 801601 ttgggatatg gcttctcggc aaagtccgtc gccggcccat gctgatcatc ggacagattg 801661 gcacgatgac agcccttctg ctgatcggga ttttatccat tgtccttgaa ggaacacccg 801721 ccctgccgta tgttgtgctg agtttgacca ttttgtttct tgcgtttcag cagactgcca 801781 tttctacggt gacgtggctg atgctctcgg aaatctttcc tatgcatgtg cgggggcttg 801841 gcatggggat cagcaccttc tgcttgtgga cagctaactt tctcattgga ttcacctttc 801901 ccattttgct caatcatatt gggatgtcgg cgacattttt tatctttgtc gctatgaata 801961 tcctagcgat tctatttgtg aaaaaatatg tgcctgagac aaaagggcgg tcacttgaac 802021 agcttgagca ttcctttcgc cagtatggcc gccgcgctga tcaggaaatc caaaatcaaa 802081 caactcactt atcgtaacct gagataccag gaggaatcta tcaatgaaac tatcttatgt 802141 aacagacagc ctagggcatt tgccttttga agacatgctc aattttgccg caaagcttgg 802201 gatcgataca cttgaaatga caaccggggg ctggtcgccg gcacctcact tgaatcttga 802261 tgaattgctg caaagcagcg aaaaaagaaa agaattttca caagcgctgg aaaagcggaa 802321 catgacactt tgcgcattaa actgctcggg gaacccttta gatccgggtg aattgggcaa 802381 atcgcacaga gacataactg acaaaacgat ggagctggct ggattattag gcgtcaaaaa 802441 agtgatcatg atgagcggtt tgccagccgg cggcccggac gacaaagtgc cgaactggat 802501 cacatacaca gtaagctggc ctcccgtttt aaaagatatc ctcaactatc aatgggaaga 802561 cgttgcgatc ccatattgga agaagcttgt caaaaaagcg gaggcctgcg gcgtggggaa 802621 aatagcgctt gagaacttca gctctcaatt agtctataat cctgagactc tctttcggct 802681 cagaaatgca gtcggcccga tggtcggttt gaatcttgac ccgagccatt tgttatggat 802741 gggcgcagac ccgatcatcg cagcaaggga gctcggctca gccattcacc atgtccatgg 802801 gaaagatgtc agaattgaaa gatatttatc ggcggtcaac ggacttttag aaacaaaaga 802861 agtgacagat cctgcaaacc gggcgtggaa ttacgtagct gtcggctgtg gacaggattt 802921 acagtggtgg aaggaatttt tttcagttgt aaaaatgatg ggatatgaag gtgaggtttc 802981 tttagaaatg gaggatctga cgatgtcacc tgaagcgggc atccgtactt ctgtagaagc 803041 tttaaaacaa accatcagcc aataggaggt tttcatgatg ctaaatggag aaagaatcat 803101 ctctaagccg cttcgctggg caatggtagg cggcgggcgg ctcagccagg ttggatataa 803161 acatcgtatt ggagcgctga gagacaatac tgcttttcaa ttaactgctg gcgcttttga 803221 tatcgatgcc gaaagaggaa aagatttcgg ggtgaacctt ggagtggatg cggaacgctg 803281 ttatcccaac tatcaaacca tgtttgccga ggaagcgaaa agacaggatg gcatagaggt 803341 agtatcgatt gccactccga acggcactca ttatgagatt tgtaaggcgg cgcttgaagc 803401 aggagtgcat gtcatctgtg aaaaaccgct gttcttcact tcagcagagg ggcaggaaat 803461 caaagcgctc gcagagaaaa aagggaaaat tgtcggcgtg acgtacggtt tttcaggcaa 803521 tcaaatgctt cttcaaatgc gtgcgatgat tgaacaagga atgatcggcg atattcgcgt 803581 ggttgacttg cagtacacac acggtttttg tgcaacagat gaaggtgaaa agataagcgc 803641 tgcacagaaa tggcgtgtcg accctgcgat cgccgggcca agctttgtgc tgggcgattt 803701 atctacccac acgtattata tgtcacagct tattatgcca aagatgaaaa ttaaggagct 803761 gctgtgtgac cgacagagct tcgtcggcag ccgcgcaccg ctagaggata atgcccatgt 803821 gctgatgcat tatgaaaatg gagcggtcgg aacgatgtgg acatcgtcaa tcaatgccgg 803881 atgtatggat ggccatagaa tccggattgt cggctcaaag gcaagcattg agtggtggga 803941 cagcaagcca aatgaactga cgtatgaagt gcagggagag ccgggccaga cactcgttcg 804001 cggcatgccg tatttagatg atgtttgcaa cgccgatgaa cgactgggcg ccttacacag 804061 cgaagggctg tccgaagcat gggccaatat ttatcttaaa tttgccattg cgatagacgc 804121 caaaaaccgt gaagatgaag aaatcttgaa caacttggtt tatcctgaca ttgatgcagg 804181 gatcgagggc attcgctgga ttgagaactg cgtgcgctcg gcaaaccaag ggtcagtttg 804241 ggttgaattt aaataaatga gggaatgcgc cgcatatgac ataaagttca tatgcggttt 804301 ttattttcca gaaactcctg tcaaaaatgc cctgaggcag gtatgataag aagggaattg 804361 ggtatcggga gtgatgagcg tgaaagctct tttttttacg agaatgttca ccttgatggt 804421 gagctgttta atgtatctgt ccattgtgaa agaggataac tggtttggat atgtatttat 804481 agcagcaggt gctgccatgt atgcagccaa tcatgttttg ctgacaaaag agacaaatgc 804541 catctggttc tgcctgattg atattgcaat cggcttttcg ttcggattta tctttcccgg 804601 cacaggtttg ttcattatta tgctttgtcc ggttgcggtc gccttttttc tgcgggggtt 804661 tcctaaaaga acagcatggt ctgtcttatg tctttcctct attttatttt tgaccgtcct 804721 catccgtaca tatgcgatgt tcggcaatga atttgtcatt gatcatttga ctagcatgac 804781 attcgttgtc ttctgcggtg tcgtgggcaa attaatccgc aagctgttgg atgcgcagga 804841 tacggcaaaa cagcagtttc aggaactgac ggagtcccat ctggcgctgt ctgctgcaca 804901 tcaggagctc catttatatg cgaagcaggt tgaagagctg actgccattt acgagcggaa 804961 cagaatggcg cgtgaaatcc atgatacagt ggggcataaa atgacggccc ttctcgtcca 805021 gctgcagctt ttgcgtgaat ggcaaaaaag agacagccaa aaagcggatg agacagtagg 805081 tgtctgtgaa acacttgccc gtgaagcgct tgatgatgtc cgcttatcag tacgcactct 805141 gcaaactgaa aacgatcctt cgctaatcga atcgctgaaa cagctgacag aggacttttg 805201 caaaaatgca ggagtcacaa cagaatttgc ggtcagcggt gatcctgcaa tcatcccgct 805261 gtctctccat ccgaccctga tcagaacggt gcaggaagca ctgaccaatg ccaaacggca 805321 cggcggcgcc gcagcctgtt cgatacagct tgcctgcaca acggacagca tcagccttgt 805381 cattaaggat gacggcaaag gcaatcctga ggcagcactt ggttttggtc tcttgaatat 805441 gaaaaagcgg gcagcggagc atggcggaat gatccgcttt gaaagcgaac gggatcaagg 805501 atttactgta aatgcagaat tttcacttgc caataaaaaa tggagcttcg ggcccgtgca 805561 gcaaaaggag agtttatcat gattaagatc atcattaccg acgatcagga tatcgtcaga 805621 gaagggctgg catccctgct ccagctccga gaagagctcg atgtgatcgc aacggcgcga 805681 aacggacagg aagccttcga aaaggcgaaa gagctggagc cggatatcgt gttaatggac 805741 atccgcatgc cggtttccaa cggggtggag ggaacaaaat taatcacaag ctcgctgcca 805801 agcgtaaagg ttttgatgct gacaaccttt aaggattcag cgctgattgc tgaagcgctt 805861 gaagagggag caagcgggta tctgctgaag gatatgtctg cagatacgat tgtaaaagca 805921 gtgatgactg ttcattctgg cggaatggtg cttccgccgg aattgactgc ccaaatgctg 805981 aatgaatgga agcgtgaaaa acagctgaaa ggaataaatg agatagaaaa acctaacgag 806041 ctgctcgacc tgaccgagcg cgaaatcgaa gttctggctg agctgggata cgggctgaat 806101 aacaaagaaa ttgccgaaaa gctttacatt acagaaggca cagtcaaaaa ccacgtttca 806161 aatattatca gcaagctggc tgtcagggac agaacccaag ccgccattta ctcggtcaga 806221 tatggtgtat ctgtcttttg acatatgacg ttttgcatat acgcttctct gaaaaggcct 806281 tttacaggcc tttttttcat gccctatgtt ctatctgccg ctacatgccg cacgcctttc 806341 tttcttctac aatggcaatg gatcaaaaaa aggagtgaga cgacgtgctg caagcagaaa 806401 acatcaaaaa ggcatacgga aaaaaaacaa tcgtgaaagg catttctttt tccctcaaaa 806461 agggggagtc gttcggtctg ctcgggccta acggtgcggg gaaatccaca accatctcga 806521 tgatttccgg ccttgtgccg catgacagcg ggaacatcac ggtgggcggc tatgttatcg 806581 gaaaagaaac ggccaaagcg aaacaaaaaa tcggcattgt tccgcaggaa attgcattat 806641 atccgacgct gacggctcat gagaatctta tgttttgggg gaaaatgtac ggacttacgc 806701 acggtgaggc caaaaaaaga gcggctgagg tccttgaata tgtcggtctg actgagcggg 806761 ctaaagataa gattgaaaca ttttccgggg ggatgaaacg aagaatcaac atcggtgcgg 806821 ctttaatgca taagcccgag ctgctgatta tggatgaacc gactgtcggt attgaccctc 806881 aatcgagaaa tcacatttta gaaacggtca aacagctcaa cgaaacgggc atgacggtga 806941 tctatacgag tcattacatg gaagaagttg agtttttatg cgaccggatc gggataattg 807001 atcaggggga aatgattgcg attggcacaa aaactgattt gtgcagccgc cttgggggcg 807061 ataccatcat tcagctcacg gtcagcggga tcaatgaagc gtttcttgtg gcgatccgat 807121 ctctggccca tgtgaatgat gtaacagtac atgaattaga gctcaaaatt gacatttctg 807181 cggctcatca tgagaaagtc gtcacaagcc tgcttgctga agccactgct catcatataa 807241 acctgctgtc tcttcaggtg caggaaccga atctggagcg cctgtttctg aatctgaccg 807301 gccgcacgtt gcgggattga ggagggacgg caatgaaaaa aagcatatgg atcgcatgga 807361 aagatgtgaa aatcagaatc acggacagaa aagggtttat gatgcttatc ctaatgccgc 807421 tcatcctaac ctgtatttta ggcgcagcgc tcggatcagt tgttgacgga ggcagccgga 807481 ttgatgatat caaagtcggc tacattcaat cagaccagtc agatacagca aacatgttta 807541 caaaagatgt tctcaaaaaa atgaagtcga taaaggtcac aaaagtcggc agcaaagaca 807601 agatgaaaaa actgattgat gaaaagaaaa tcgatgtagg catcgttatc ccgaaccatt 807661 gggaagccgg caaaacctca gctgttgtta atgccgctcc tgatcaaaca ttgaaaagtt 807721 ccatcattga aacagctgca agctcattta tagagcaata taaagcggta aaggaagccg 807781 cgtcaggctc aatggactac atcagtaaaa cggaagctgt aaagcaagga aaacttgacc 807841 ctgcacagtt tgcagaaaag ctggcaaaga cgctagaaaa agaaacaggt gacaagctta 807901 ctattgcgga aaaatctgtc ggcagcaaag ccgttaccag ttttcaatac tattcggcgg 807961 caatgctttg catgtttatg ctgtttcata tcacagtcgg ggcgaaatca tttttacagg 808021 aaaaggatac ggagacgctt gccagaatgc tgatgacgcc tgcgcaaaaa tccgtcattc 808081 tcttcggaaa atggcttggg acgtatctgt ttgccatcat acaatttttc atatttctga 808141 tcgtcacaat caacgtattt ggtgtggact ggggcggtaa tctgctgtta gtgagtgtac 808201 tcgggctttc ttacgccgca gctgtatctg gtatttcaat gctgcttgcg tcgtgcatca 808261 gcgatatgaa aactgcagat gcgataggcg gcttcggcat tcaattgctt gcggttctcg 808321 gcgggtccat gctgccgctg taccaatttc cggacgtctt gcagtctgta tccaaagcgg 808381 tgccaaatcg ctgggcgctt gacggctttc tttctttaat ggaaggggga ggctgggctg 808441 accttcaaaa gcctgtgctt ctttttgcgg cgatcggctt ttgttcactt gtaattggta 808501 tcagacggct tcatacaaga taaggaggta caaaaggtga aaaaaattct agccatttgc 808561 ggcattgagc tttctctcat ttttaagaag ccacagaact atttgatcat gtttgctgcc 808621 ccgcttttgc ttacctttgt atttgggagt atgctcagcg gcaatgatga taaggtgcgg 808681 cttgcaatcg ttgatcagga cgatacgatt ctctcacagc attatattcg gcagctgaag 808741 gcacacgatg atatgtatgt attcgaaaac atgtctgaaa gcaaagcgtc agaaaagctg 808801 aaacaaaaga aaattgccgg gatcatcgtc atttcccgct cgttccagac acagctggaa 808861 aaaggcaaac atcctgagct gattttccgt cacggccctg agctgtcgga agcgccgatg 808921 gtcaaacaat atgcagaaag cgcattggca acgctcaata ttcaggtgac cgcggcaaaa 808981 acggcatctc agacagcggg agagaactgg aaggcggcgt ataaaacggt tttcgccaaa 809041 aaacatgaag atatagttcc ggctgtaaca cgacagacgc tcagtgataa aaaagagggt 809101 gcggaagcaa gtgacacagc ctccagagca gcagggtttt ccatcctgtt tgtcatgctg 809161 accatgatgg gagcggctgg aaccatttta gaagcaagaa aaaacggcgt atggtccaga 809221 ttgcttacag cctctgtcag ccgagccgaa atcggtgctg ggtatgtgct gtccttcttt 809281 gtcattggct ggattcaatt tggaatattg cttctttcca cccattggct gtttggcatc 809341 aactggggga atccggctgc agttattgta ttagtgtcac tttttctatt gaccgttgtc 809401 ggcattggat tgatgattgc ggccaacgtc agaacgccag aacagcagct tgcgttcggc 809461 aacttgtttg tcatcgcaac atgtatggtg agcgggatgt attggccgat cgacattgaa 809521 ccgaaattta tgcaatccat cgctgaattt cttccgcaaa agtgggcgat gagcgggttg 809581 acagagatta tcgctaacgg tgcccgcgtc acagatattc tcggaatctg cggcattttg 809641 cttgcatttg ctgcgatcac tttcgcagcg gggctgaaag cgctccgagc ctaaaaaaca 809701 tctgccgttt aggcagatgt ttttttgcat gtgggtacat tcgtatgggt gcagcctgaa 809761 ctgcggttaa tccttatcta tcatagctaa aattgattcc agccaagaaa cgtaattttt 809821 ctcccgctcc agcgctttcg ttagcacaag atagtggccg aagtccggtg aagaaaatga 809881 catcggctct gctgaagcca taagcttttc atagcttccc tgtaagtcag aaagcttggc 809941 ctggcgtttt tgcagctggt ctttgaacaa atcagaagcc tcctggcgcg atagacaaga 810001 aatgaaataa gccttcagca taaattcatc cttcaccgtc tcgggtatcg gctggtggcg 810061 gatcagccag tcatgcagct cctgctttcc gctgtctgtc agggtgtaca tctttttctc 810121 cagctttgtg ccctgaatcg ttgtccggaa cgtgataaat ccttcatccg tcagcttttt 810181 gagctcaggg taaatctggc tgtgcttggc gctccaaaac tggccgagct cctctttaaa 810241 ataactcgta atatcgtatc cactcaattc gccttttcgc aaaagcccta atatggcgta 810301 ttttaatact ctcatgctat cctccgtgtc tggctgtttc gcaaaacaga tgagccggtg 810361 ctcaactgtg attctaactg cctattcccc ttattataga aaagggagga agggaacaca 810421 accgggctct ttggaaatga agataaaagg tttgtcagaa ggtatccgat ttatctccgt 810481 caatataaaa gagatttaaa tttaattttc agaaaaaata gtaacgatat tgatttttta 810541 tatataatag gaaattggtg gtatgaaaat tttttggggg aataaacgtg aaaaaagtac 810601 ttatggcatt cattatttgt ttatcgctga ttctatctgt tttagccgct ccgccgtctg 810661 gcgcaaaagc tgagtcagta cataatcctg tcgttcttgt tcatggaata agtggtgcat 810721 catacaactt tttcgctatt aaaaactact taatttctca aggctggcaa agcaacaaac 810781 tgtacgcaat tgatttttat gataaaacag gaaacaacct aaataacggc ccgcagcttg 810841 cttcatatgt tgaccgtgtt ttaaaagaga ctggggcaaa aaaagtagat attgtggctc 810901 atagtatggg aggcgccaat acgctgtact atattaaata tttaggcggg ggcaataaga 810961 ttcaaaatgt cgtaacgctt ggaggggcta atggtttagt gtcatcaacc gcgctgccgg 811021 gcacagaccc taatcaaaag atcctctata catctattta cagtctcaat gatcaaattg 811081 tcatcaatag cttgtctcgg ttacaaggag cgcgaaacat ccagctttat ggcatcggtc 811141 atattggctt gctttctaat agccaagtga acggctatat caaagaaggg ctgaatggcg 811201 gaggcctcaa tacaaattaa tatcttcaaa aaacaacctg ctgtctccgt tacagtgggt 811261 tttttcgtct gagaaagcca tagggtctta tgaccttagt ctatcatgca tacgtcaatt 811321 tatgacatca ggcacttttt caaatagagc ggacatgtta aggtacaacc atcgatttct 811381 atcaatttga aataaaagga gcgctgttat gcaaattaaa gaaattttta tgatccgctg 811441 catttcgtgc ttaagtgtcg tcttgctcca tatcatttca atggtcctga tgcttcaggc 811501 agaagctctt gcagatattt ctcacactgt tgattctttc cgcacactcc tgatgttcag 811561 cacgcccgct tttattttca tctctgaatt tttactggcc cgttcttatc ctgatggggt 811621 gcctgacggt tttttaaaga agcggggaaa agtgattttt gttccttttt tatttatcgc 811681 agccatcgat gcgctgctga tgaccagtgc gatgggggga gaggtaacct ttctcgcgtt 811741 tgtgcaaaaa tatctggcga acgtattctt aggaaacttt atcggatact tcattctcgt 811801 catctttcaa ttttacatgc tgcatatgat gtttcatgag tatttgaaaa aagcatcgcc 811861 gaaatgggtg ctgtctatct catttgtggt gacagccgct tatttaggct atttctccgc 811921 agccagcccg gctcctgctt ctgaagaggg aggggcattt ccgttcttct gggttccgtt 811981 cgcaggctgg cttttctact tttgtctagc ctactattgc ggaaaagaat acaagcgttt 812041 tttagcgctg ctgaaccaat accgctgggt ggtgtacggc gccgcaattg cttctggggc 812101 gctggttgtc actgtttctt atgtcggtga aatcggcatg atcagctcga agcggcctga 812161 tatcatgctg tattcaacaa gcatgatttt cctgtgtttt catttgtttt ccaaaatgaa 812221 gcatgtgccg aaaatcatga tgtttatcag caactattcc ttttcgattt atctgcttca 812281 tgcctatttt atgattatag gctacgtgtt gcttttgaat atgcccgaaa ttcctgccgt 812341 accggctgtt ctcctgttgt ttgccgtgtg cacagccggc ccgattatga cctcatgggc 812401 gctgaataag ttcaaatacg ggtatttatt tgtggggaaa atttatcagc caaaacagaa 812461 gaaggtaaca gtcgaagtgc gtgatcacgc agggtgaaaa acaagcggca ggagggctcc 812521 tgccgcgttt ctttacttct catccgcttg cagaactgtt tttaaatata gttttgcaga 812581 ctcagcaagt ccagatacat cagccttttc ttcatcgaaa tacagggcgt tttgaatgat 812641 gccgtcattc atattgagga aaaacttggc gatagtcgca agaggctgaa ccggctgaaa 812701 ctctccctga tcgatccctt tttgcaatag ccttgaaaac ctttccacaa aaagatcata 812761 ccttttctcc aaatactgcc gccgttcttc attgcgccaa gctgtcacta aatattcaaa 812821 ttgcaccggc gccagcgtat ctgctacatc tcgcaggccc tcagtcagtt catccaaata 812881 gctggaaatg gaggcccaaa cactttggtg ttcagctgat ttatcaagct ttcggagtcc 812941 ttcatccagc cctgtttcaa taatgcggcg aaacatctcc tcagtgcttg aaaaataaag 813001 atagacaccg ccccggctga aacctgactc ttctacaaca tccttcatcg tcgttaattc 813061 gaatcctttt cgtttaaaaa ccgttttggc agcctctaaa atctctgcct gccgtttatc 813121 cttgtgctcc tttgttactt ttggtgacaa gatatcgcct gctttctgca attttcttac 813181 ctataagtgt aatcaaccca atcatgatca gcaagcagcc acagacaaga aaagcaagtg 813241 atacaccgat ccattccgcc agcacgcccc cgcccgccat gccgaggata gaggcgaggg 813301 ttgtcgcact ctgaatagcg ccgaacaccc taccgctgta atcgacaggc actgttgttt 813361 gcacgagaat ctgaaatgga atatggacga ggccgaaagc cgcccccatg atgaaaaaag 813421 caaatataaa gagagtgatg ccggcaattc ccataccgct taggaatggc gcacctccag 813481 ttgctagtcc aagaagaagg gttccagctg agaaataaag caaataagaa gtgattcgcc 813541 gtctgccggt aatggccgct gtaaggagca tcccggctcc gcttacggcc atgcaccagc 813601 ctgccagctc gggcggagct cctgaaaagg agcggataag aataatcgct tgggaatcac 813661 caatctgcaa aacaaagaga acgacacaag ctgttagtaa gcctgttaat agaagcggca 813721 tccgtttcaa aaactgaagg ccttccttga tagaagtaag tgctgctgtt ttttcttgag 813781 gtgtattggc tttttgtaaa aaagcatctc tgggaaggaa aaacaaaatg acagcggaaa 813841 gaaagaaggc gccggcgttt atataaaaaa cagagtgtat cgagaaagca gcgatcagcg 813901 tgccgccaag ggcagggccg aagatttttg agctgttatc aatgatgctg ctgacggaaa 813961 cggcctgctg aatgtgtgct tccggagcca attccttaag ctttccgttt ttagcaggta 814021 aaaaaagtga agaaaaacag ctctgaacgg atagcaatac gtaaagctgc caaagctcac 814081 tgacataaac gcagctgata acagtgaggg cacggccgat ttcagataga aacatgatcg 814141 tttttctgtc aaaacggtcg gcaagcagac ccgatacagg tccgagtaca atgacaggca 814201 aagcaaacga catcattaaa agcgacatat ctaatggaga agcatgaagc tgaaaagcgg 814261 ctaatgttag cacggccaaa atgtgaagcc agtctccaag tgaagaaatg gtttgcgagg 814321 ctaacagtgt catcagtcct ttttgattgc gaaacaacgg tttttccatg attcatcctc 814381 ctgattatta aaatgacact agtgtcgttt ttaattgtat gggaaaaaga cacaatatac 814441 aatctttttc ttgtaaaata aaggagaaga ttgaatagaa gggagaacat tcatgacatc 814501 agtcaatcta agctacccaa taggagaata caagccgagg gaatccatat cgaaggagca 814561 aaaagataaa tggattcaag tacttgaaga agtgccggca aaattgaagc aagctgtaga 814621 ggtcatgacg gacagccagc ttgacacacc gtaccgggac ggtggatgga ccgttcggca 814681 agttgttcat catctggctg acagtcatat gaacagctat attcgtttta aattgagctt 814741 gacggaagag acaccggcta tccgtccgta tgatgaaaaa gcatggtcgg agctaaaaga 814801 ctcgaaaacg gcagatccga gcggctcact cgcgcttttg caggagcttc acggaagatg 814861 gacggctctg ctccgcaccc tgacggatca gcaatttaag cgcggatttt atcaccctga 814921 tacaaaggag atcattaccc tggagaacgc gctcggcctg tatgtctggc actcacatca 814981 ccatatcgct catattacgg agctttccag acggatgggg tggtcttaac gcttttgccg 815041 gcggaaagcc ggaatactga tagcagcaat caccagaagt gagaccacag cagccgctgc 815101 atataaatga tcatagccgc tggcgacact cgcatgaatg gcgtcgctta tcgcggtttt 815161 gacttcagga acgggaatgc gttcgatttg ttcttgtaaa gaagaaactt cagaactgtc 815221 gatctccgga atcatctgca tcgccttttc tgaatatccg ctgtccgata agcggctgtt 815281 gatctcatca cctatttggt caaacccggc tgtgataaaa cctgcataaa gagtaggcgc 815341 caaggtcagt ccaatttgcc ttactaatga aagcgtgcca agagctgtac ccttatttgt 815401 ttttgccgct tctgatacaa ggacgttcag cggagcgcct aacagaaagc caaaaccgat 815461 cccagctgcc acacttgcga tcacaaactc ccatttttcc gtgacccaga gcggaaataa 815521 agcaaacccc gcacatgaga tgattcccga aagaataacg gtttttacag gacctttttt 815581 gtcggtaagt gctccgccaa gccaagcgcc gattccggaa gccaacgcaa gcggtgtcat 815641 ccaatagcct gcttttgcgg cagggacacc caaatactgt tcgacatatg acgggataaa 815701 aatgactgcc gccaagagcc ccccggataa caaaccgatg ataagcgtgc gctgaaacat 815761 atggtttcgc agcagagaat acgccaaaat gggatcgcct cctcgcattt caactctctt 815821 ttcatacgag ataagcgctg caaaacagag tatgccaaaa ataatacatc cataaacctc 815881 cggattcccc aagctgtgta agagatttgc cccgtcaaga ttggtcatgc cgtacatcac 815941 agctaaaatc gacagggaca aaaggaagat tccggccgca tcgaggcgct tagcctcagg 816001 tgcttttgtt tccgcgataa aacatgcgcc gaaaacaacc aatagcacgg caatcggcaa 816061 attaatcaaa aatagccaat gccaagaccc ggtccaatca agcagaaagc ttccgatatt 816121 tggcccgagc acagcggcca tcccgttcat tgcgccaagc agcccaagcg ccttcccctg 816181 tttttccttt ggaagggtcg cgagaatgtg agagctgccg atgatgaaaa tcccgccgcc 816241 tccaagcgcc tgaatcagcc gcgatatcag aaagagcggg aagctttggc tcaaagcaac 816301 aagcaaagaa ccaagtccga acaggcaaac ctcaatgaga aagagttttt ttctgccgta 816361 gcggtcggaa agttttccga cgattggcac actgacgcta agaccgagcg tataaagggt 816421 aatgccccat gatccccagg aaggggaaac ggaaaacgac tcgtttatcg ttgttaaagc 816481 agccgaaata attccgttat ctaaagcagc cataaacacg ccaatcgtaa acaggctgat 816541 tgcccacttt tggcttttct gctctgttaa tgcttcagac attttcgtca actcctttta 816601 gttcacttga aatatattat tcattttaaa tgaactaaat gtcaaataaa aaaagcctgc 816661 tcccgcagtt tgcggatgac agacttactg atttattctt ttttcgcatt ctctaatgct 816721 cttgaaagga tagacagccc ttcgtaaaca gcctgctttt cttcagggga cagcagctct 816781 aatgaacgct tcaatttcag gtggcccttt tcatacaaac cccggaaaat ctttttcgca 816841 ttctctgtca actgaacaac tacagagcgg cggtcctctt cagaatgtga gcgtttgaca 816901 aatcctgatt tttcaagccg gtcaagcagc ccagttgtat tggacaggga agcccccatt 816961 ttttcagcaa tgtcgctcac tttcaatgtt ccatggttgt ttaatagcat cagcaccttc 817021 atttgcggca tgctcatatc cagtttcatc cactcggaca catcaccgag cccggcggac 817081 gttaagactt tcatatagag cacccatatt tcccgttcct ccgatgaaag aatgttttcg 817141 tttaagactg ttgtatcgtg taaattatat tccatttcat cacttcctca tcattcactc 817201 ctcttaccat attactcgat tttcactcct gaaagaaagt gagcagaaac cgcatgcggg 817261 actttgtccg aaaaataacg gtagtgtata atgagttgga gattattggg ggagaggatc 817321 gaactagaat atgattggag agaccattgc tgattaaaaa gaatgcttta tcaatattaa 817381 aaatcgtttt tcctattgct gttttgctat ttgttattta tcaatcgaaa aaagaactga 817441 caaatctgtc attcaaacgt acgctcatgg tcatcaacgg actggaacga acggatttat 817501 tcatgcttgt gttgatcggc ttgctggctg ttgcggctat gtcgctgtat gattacgtcc 817561 tgaagtactc actgcgccta tcgatcacaa acggaaaagt tttcagggtt tcctggatcg 817621 ccaattcatt taataatgtg ttgggattcg gcggtttagc cggagtcggg ttaagaatga 817681 tgttctataa ggagcatacg aaagaccata aggcactcgt gaaaggaatc gcctggctca 817741 catcatctat gctgctcgga ttatctgttt tcagcatttt cgttgctgcg agagtgctgc 817801 cagttgatga agtgattcat gagaagcctt ggctgtgggc ggtcgttatc ggttttgcac 817861 tgatattgcc gttatcttta gcggtgtcca aaataaaaga ccgcaaagct ggggacgaag 817921 agaatgcgga taaagtgaaa aatccgattt tcgcatatat tggagcttca gttgttgaat 817981 ggctcatggc cgggaccgtc atctattttg ctttgttcgc tatgggcatt catgcagata 818041 tcaggtatgt gttcggggtg ttcgtcattg cggcgatcgg aggaatgatc agcctcgtgc 818101 cgggcggctt cggctcgttt gaccttttat ttttgctggg gatggagcag cttggctatc 818161 atcaagaggc catcgttact tctattgtgt tgtacaggct cgcctactca tttatcccat 818221 ttatcttggg actgttcttt gccgccggcg acctgacgga aaatacaatg aagcggctcg 818281 aaacgaaccc gcgcatcgca ccggcaattg agacgacaaa cgttctgctt gttgttcagc 818341 gtgcggtatt agtgagaatt ttgcaaggct cgctttccct tattgtgttc gtagcaggtc 818401 tgattgtctt ggcctcagtt tccttgccga ttgacaggct gacggttata ccgcacattc 818461 cgcgcccggc gcttttgctg ttcaacggcc tgtccttaag ctcagcgctc attctgctca 818521 ttttgccgat cgagctttat aaacggacaa aacgttccta cacgatggcc attacagcgc 818581 ttgtcggcgg ctttgtgttc agctttttaa aagggcttaa catcagcgcg atattcgtac 818641 tgccgatgat tatcgtattg cttgtgctat tgaaaaaaca atttgtccgc gaacaggcat 818701 cctatacact gggacaattg atattcgctg tggcgctgtt tactgtggcg ctctttaact 818761 acaatctgat cgcgggcttt atttgggacc ggatgaagaa ggtgctgcgt cacgaatatt 818821 tcgtccacag cacctcgcat attacacatg caaccatcat ggcgatcatc attgtgccgc 818881 tgttcttctt gatatttaca gtggtctatc ataagagaac gaaaccgatc ggagagaaag 818941 ctgaccctga gcgtcttgct gcgtttctca atgaaaaagg cggcaacgcg ctgagccatc 819001 ttggttttct tggagataag cggttttatt tttctagcga tggaaatgca ctgcttctgt 819061 ttgggaaaat cgccagaagg ctggtcgtgc tcggcgatcc atctggccaa agagaatcat 819121 tcccgctcgt gctggaagaa tttctgaacg aagcgcatca gaagggattc agtgttttgt 819181 tctatcaaat tgaacgagag gacatggcgc tgtatcacga ttttggctac aacttcttta 819241 aattgggtga ggaagcatat gtagatttaa atacatttac cttgactggg aagaaaaaag 819301 ccggccttcg ggcaatcaat aaccgctttg agcgggagga gtatactttc catgtggatc 819361 atcccccatt ttctgatgcg tttttggagg agctgaagca aatctcagac gaatggctcg 819421 gctcgaaaaa agagaaggga ttctcgctcg gattttttga tccttcctat ttacagaaag 819481 cgccgatcgc ctatatgaaa aatgcagaag gagagatcgt tgcattcgca aatgtcatgc 819541 cgatgtacca ggaaggagag atatcggtcg atctgatgcg ctatcgcggc gacgctccaa 819601 atggcattat ggacgcattg tttatccgta tgtttttatg ggcaaaggaa gagggctgta 819661 cgtcatttaa tatggggatg gcacccttgg ccaatgtcgg cactgccttt acatccttct 819721 ggtccgaaag gtttgccgct gtcattttta ataatgtcag atacatgtac agtttcagcg 819781 gcctaagagc ctttaaagaa aaatataaac cggagtggcg agggaaatac ttagcgtatc 819841 ggaaaaacag atctctttct gtcaccatgt tcctcgttac acgtctgatt ggcaaaagca 819901 aaaaagactc cgtctaataa gacggagtct ttttttattt cgtttttaag aagtaggttt 819961 caatatcatc aagcaggtag tttgcggctt taattccgcc tgcggttgtc catacgacgt 820021 catcgacttc atgtgcatta cctgacttca cggccttcag gtttttccat agtgaactgc 820081 ttgtccactg attggcccat ttttcatttt cttttgcatt atcggcttta taagtgaaat 820141 aaaacagcac atcagcatcc atatcaggaa tagattcttt actgtcggtt gagaacgtaa 820201 attggtcctt ttgtttctta aacagttcca cttgtttttc agggcgtttg aagccaagct 820261 ggtctaaaat aatcccagga aatgaatcgg tataatagat tcttgattca ccggataaaa 820321 agcgtacgac tgaaacggtt ttgtttgtct ggtcgcccag cttgtttttt aaatcagaaa 820381 cacgtttatc aaaatcggca atgacttcct tgcctttgtc cgccttattc accgcgttgg 820441 cgtatagagt caggttatcc ttccagttcc cggccaaaga ttcagcaaaa acagtcggcg 820501 caatcgcatt taactgatca taaatttttt cctggcgcac tttgtttcca ataatcaaat 820561 caggctttaa ttctgcgatg gcttccacat tcggttccgt ttcaagaccg acgtttttaa 820621 cacctttcat gtcatctttc agatagtcat accacgggtc gcccttccat gactttacgg 820681 ctccgaccgg cttaatgcca agcgctaaga gcgcctctgt tccttcatta gttaaaacaa 820741 caatccgttt tggattggcg gggatgttgt ctgatgtccc cattgcatgt ttgaccgttc 820801 ttgttttgct gcttgacacc tcgctgttgc ttgaactttc tgaactatta caggcagaaa 820861 gtaccataac ggccattaaa aatacgaata gcatgctgat atgctttttc atctttttcc 820921 tcccaatatt gaaattcatt atcatttaga tcataataag cagtgttaag agtgtcaatc 820981 cctaattgag gattattctc aaaaacaaac attacatagt aaataactag gagaattaga 821041 tcatgatctg caaaaaggca tcttcaaaat ggattgtgtt agtatgtctg attttcattt 821101 tactgacggc tgtctgcgca agcgtcgtgt atggctatac aggtacgtca tggagacagg 821161 tctatcaggc gtttacttcc ttcaatggaa caaatgagca tgtcatcatc aaggatgtca 821221 ggcttccgcg cgctttggtt gcgacagtcg tcggcgcctc gcttgcagcc gcgggcgctc 821281 tcatgcaggc gctcacaaaa aatccgcttg cgtcaccggg gattttcggg attaacgccg 821341 gtgcaggttt ttttattgtt gccggatcgt tttttctgca tattcagtca cctcaggcat 821401 tagtatggag ctcgtttctg ggggcagcat ttaccgctgc gatcgtctat gcagcaggct 821461 cgcttgggag ggaagggctg acgccaatca aactgacgct ggcgggagct gccatggcag 821521 ccatgttttc ttctctgaca cagggcttgc tgtctgtcaa cgaactcgag cttgcccagg 821581 tgcttttttg gctgactggc tctgtgcagg gccggagtct ggatctgttg atgacgatgt 821641 ttccatatgc agcggcagcg ctggtaatct gcttctttct cggccaaaaa attaatctcc 821701 tcgttatggg agaagatgtg gcaaaaggac tcggccaaaa aacaggcctg ctgaaatttg 821761 tgatggcgct ttgtgttgtc atgcttgcag ggtccgctgt cgccattgcc gggccgattt 821821 cttttatcgg catcattatt ccgcattttg cccgctttgt cgttggtaat gattatcgct 821881 gggttctgcc attttccgct gttttgggtg ccattttgct tgtttgcgcg gatatcggtg 821941 cgcgatatat cattatgcct caggaagttc ctgtcggggt catgaccgcc atcatcggaa 822001 tgcctgtgtt tgtgtacatc gcaagaaggg gggcgaagct atgaaacttc gttttggcgt 822061 tactgcggct gaaaagaaag catggatcgt ctttttggtt ttactggggt taacagctgc 822121 tgtactcatc ataagcgctg gtctcggaca aaggtttatt cctccctggg atgtagcaaa 822181 aacattcttt ggtgcaggtt ccaagctgga tgaactgatg atcatgtcgt tccgcatgcc 822241 aagaattttg acggctttat gcgccggtgt ctgcttggca gcggcaggcg cgatattgca 822301 ggggctcgtc agaaaccctc tcgcatctcc ggatattatc ggaataacag gaggagcggc 822361 ggtagcggtc gtgcttttaa tgatgttctt ctcagaccgc agcagttcac ttacgatcag 822421 tctgtcatgg cttccagcag ccgcatttat cggcgcatcg gctgtcgggc tcatcgtcta 822481 tttactggca tacaaaaatg gcgcctccac atttcggctg gtgcttatcg gaatcggatt 822541 ttcaatgtcg gcgcaggcga tgactaccct gttgatgatc aaaggcccga tttaccgagc 822601 atcacaagcc aatgtgtata tcactgggtc agtttatggg tcaaactggc agcatgtaaa 822661 aatagctatt atcttatctg tcattctctt attcatttgt tttgtcgcgc taaaaaatat 822721 gaatatacag gtgctgggtg aagatattgc ggcgggtgca ggaagcgctg tgcagcgaaa 822781 tcgttttttc ttgctccttt tgagtacggc tcttactggt tgtgcagttt cagttgccgg 822841 cacaatcggt tttgtcgggc tgatggcgcc ccatattgca agacggcttg tcggctcatc 822901 ttatggcgcg ctgctcccag cgtcggcact tattggagct ctgctcgttt taacagctga 822961 tatcgtcggc agaaccttat ttgctccggt ggaagtgccg gccggcgtct ttacagcggc 823021 tatcggcgca ccttatttta tttatttgct ctataaaaca agaaattctt aatcgttaca 823081 cccattttct taaaaaagaa aatgggtttt tttgataatg actgaagatt cgtaattatt 823141 tttgctatac tgacagagac attgataaag aaagggcggc agatgaatga aagaagcaga 823201 ggtattaaaa tatgaagcat ttacaagcag tcccggcaaa ggaaaccccg caggcgtcgt 823261 tttgcaggga gacgattata cggaagacga gatgcagatc atagctgaac gtgccgggta 823321 ttcagaaacc tcctttatcc gaaaaagcga gtcggccgat cttgaactcc gttactttac 823381 ccctggacac gaaatgaatt tgtgcggtca tgcgacagtt gcttctcttt acgcattatg 823441 tgagaaagga atgctggaga gcggtaaaac gtacagcatc caaacgaaag cgggtatcct 823501 gcctgtgaag atttctgaaa aagatggccg cattcatatc acgcttgaac aggcctctcc 823561 gcaattcaaa ccatttacag gcgatcggaa aaaacttgcg gacgcactgg gtatcaccga 823621 tgaagatttt catgaagacc ttccgattgt gtttggcagc actgggatat ggacagccat 823681 cgttccgctt aaatcattgg aggcttccaa aaaaatggtg ccagataaca aacaatttcc 823741 ggaagtgtta gttgatctgc caaaagcttc agtccatccg tttacctttg aaaccgtcca 823801 tcccgacagc gacctgcacg ggcgccactt ttcatccccg tattcgggaa cgattgaaga 823861 ccccgtgacc ggcacagcat ccggcgtgat gggggcttat atgaaacatt atggcaatgc 823921 cgagcagcat aaatttatca ttgaacaagg gcaggaaatt ggaaaagacg gaaaagtgga 823981 gatcgaaatg aacgaagccg gcggccatgt gaaagtgaac atgacaggaa cagccgttta 824041 ctcagaaacc cgtattctta aaatctaata cggatgatgg tttacaaaaa gatgcacttt 824101 ccgttatcat tatgaaatga taatcatttt caattgcata ggaaggtgag acggtatgcc 824161 tcaaaccgaa caaatacatc agcattcagt actgagggac atcatacgca gcagaagatc 824221 gattcgaaag tttaaacaag agccagtacc ttcagcagtc attcttgaca tgcttgaaac 824281 ggcaaaatat gcgccaaatc acagagtgac agagccatgg agatttattt acgtttccag 824341 tgagacaggt aaagcgaacc tcattaatac atttgcagcg ttctctaaga aatccaagcc 824401 ggatatgaca gaggaaaagc ttcaaaattt caaaaacaca cttgggcgcg ttccgggatt 824461 tctcctcgtc gtgtttcagg aagatgaaaa cgaaagagcg cgggacgacg attttgcggc 824521 aacaagctcg ttgattcaaa atcttcagct tctcgcttgg gaaaaaggaa tcggcatggt 824581 ttggaaaagc ggaaaaatcc tttatgacaa agaagtccat caggcctttg gtttacagga 824641 taatgagcgt ttcgccgcca tcatacaaac aggttatcct gacgaggcgc cggaagtgaa 824701 aaaacgcaca ccgatccgcg accgattcac tgaaatgtaa aaaacccctt gtctcaaacg 824761 gagacaaggg gtttttcatt aacgagattt ctttttcgct ctgttgtcgg ctgctttcgc 824821 acgctcttgc gcttcgcggt catctgcatc agcaagctcg gttgaatatt cttcgtaaac 824881 gccgtcagtt tcccttttta aggcatcggg aacttgtgga agcttttgtt tgtttttatc 824941 acggtttttg tggatatgat ttctgcccat atcaaattcc ccctaaaaag tgatatcaaa 825001 caaatatagt atttggtttt aaggggctat gtattcctac ttccgcttag cagctttttc 825061 cgctttttta aattcgcctg aataaagaac ttcctgcatt tttttcaggt tggcgccttg 825121 ctggtgcttc tccctctttt tttccataaa aaggacctcc ttcaaccatg ttattcttaa 825181 ggttgacgct tcctgctgtt tttatacagt ctttcggtcc gctatcagct gtgagagtgc 825241 aaattcaaga tccgaatatg taaaacgaaa tccagaggtt atcgcttttt tcggaagagc 825301 gcgctgtcct ttcacaatca aaagactcat ttcacccaat gcttttgata aaaagaattc 825361 cgggacgggg agccagtgcg ggcggtgctt cacccgtgca atcgtttttc cgaattgctt 825421 catgtccaca ggattgggcg cggtgacatt cattgggcct gagatgccgg cgttttccac 825481 cgcatatcgg atcatctggg ccgcatcctc gacatgaatc catgacagcc actgccttcc 825541 cgttccgatc gttccgccgg ccagaaactt ataggggaga atcatgagcg ggagagcgcc 825601 tttttctcca agcatcacgc caaatctcgc ataaactgtc cggatgccca tcgcttcaat 825661 atgctgtcct tccttttccc acaggtgtgc agtatggctg agaaaatcct catctgacgt 825721 tgcagaatcc tctgtgaaag ttttctcaag gcttgtgccg taaatgccca cggcactggc 825781 ttggatcaat gtcttcggct tctccttctg tttctgaata agccgctgca cttcacgcgt 825841 cgcattgata cggctggaga gaatgtgctg cttcgttttt tctgtccagc ggccaaaaat 825901 cgattttccc gcaagattta tccagacatc aatatgagga agttcctgct ccggtgcggc 825961 tccttccgac agccattgga catatgtcat atttttttgt tcagtttccc ttgcgtttct 826021 tgataaaata taaacatggt gtccctggcg ggtaagaacg cctgtcagat gctggccgag 826081 aaaaccggtt ccgcccgtca ttgcgatatt catgaacatc tctcctcatc gttctaataa 826141 atatacttta cctcattgta ataaaagaaa acgcgtttca ggcctgagaa gggagattaa 826201 gatgccgttt attacaaaaa tatcaacgca aaaaaagaat acggaacgct tcaatatttt 826261 tctggatgat aaatacgcct tcagcgtgga cgcggatgtg ctcgtgaaat ttgagctcaa 826321 gaagggaaaa gaactcgatg atcttgacat cattgagatt caatacggcg atgaagtgaa 826381 gaaaggcttc aaccgtgcgc ttgacttttt atcctatcga atgcggtcga cgaaagaggt 826441 cgaggatcac ttaaagaaaa aagaaacctc gccccccgtc attgcggaag tcatccatag 826501 gcttaacgat tacaagtact taaacgacca ggaatttgcc gcagcctatg tcagcactca 826561 caaaaaaaca aacggaaaag gccctgatgt tttgttcaga gagctaagag cgaagggaat 826621 tgatgacgat acaattaagg aggcgctaag ttccttttcc tttgaagatc agacaagaga 826681 agcggtcaag catgttgaaa agcttctcaa aaaagataaa aagctttcga cgaaagaact 826741 caaacagcgc gcccagctgc agcttcagcg caagggcttc tcatttgatg ttatcagcgc 826801 ggcgatggat cagattgaat atgaaaatga tgaagacaca gagaaagaag cgctgcgcct 826861 tcacgcggaa aaagcgttta gaaaataccg ctatgacggc tcatatgaaa gcgccatgaa 826921 ggtcaaacaa tttttattcc gcaaaggatt ctcactcgat ttaatcgagc aattactgca 826981 ggaagaggag tactgaaatg gagaaacgat acagtcaaat gacaccgcat gaactcaata 827041 ccgaaatcgc attactttct gaaaaagcaa gaaaagccga acagcatgga atcataaacg 827101 aactggcagt gctcgaacgg aaaattacga tggcaaaagc atatttgctg aacccggaag 827161 attactcacc gggagaaaca tatcgtgtgg aaaacactga ggacgagttt accatcagtt 827221 atttaaatgg cgttttcgca tggggataca ggacctcttc ccctcagcaa gaggaagcgc 827281 tgccaatctc agtattgcaa gaaaaagaat aaagcgtaac aggaggctga tgatcagcct 827341 ctttttgttt gcagcacatt tacacgaatt cttaaagaaa aaatcattga attcacttga 827401 aaaatctttt aagatgaaac tcgttgtttt ttaaaatcaa aggaggcgat gacgttgagt 827461 atcaaaaacc catctgtaaa atttattata tttgttctta tgatttgtac attttcaatc 827521 ggctatacag aatacgcggt gatgggtatt ttgacgtcga ttgccaatga ctttcatata 827581 caggtttcat ccgcagggct tcttgtcacg gcttatgcgg caagcgtttg tttgacaggg 827641 ccgctcgtca ccatcatttc cgtcaagctt ccgagaaagc ctgtgcttct tgggctgatg 827701 gcgatattta tcctttccaa cctgatgagc gcactggcgc cgaattttgc ggtattggcc 827761 atttcaagaa ttttatctgc gtccattcac ggcgctttct tcgcgattgc catggtattc 827821 gcaagtgaaa tggttccgcc ggaaaagcgt gctgcagctg ctgcttcaat gaacggcgga 827881 ctgacagtgg ctctaatgct tggtgttcca ttcggctctt atctcggaga tgtcctgaat 827941 tggagagcgg tgttttccat cattacggca cttggtgtca tcggattttt aggccttatg 828001 gctgccgtgc cgaacagaaa accaaaagtg atcccaatgc ttatgaatga gtggggtgtt 828061 tttaaacaca aacaagtgct gttttccttc gcgattacca ttttaggcta ttccggtgtc 828121 tttatcgcct acacctttat cgaacccatt ttgaggcatt cagccggatt cagcacggtt 828181 ggcattacag gtgctctctt tgcgtatgga ttgggaggcg ttgccgggaa tttctttgct 828241 ggaaaggtac cgctgccttt gctgactcgg acgatgatcg gcgtaatgat cggtttaatc 828301 ggtgttctgg ctgtatttcc ttacatcgcc atttacccgg ctgcagccat tgtggcaacg 828361 ttcctattcg gggcatgcgc attcggcacg ccgcctcttc tgcaaacaaa ggtcatttcc 828421 tcatctgagg gcggcacaac cattgccgca gctgtcagcg tatcagcatt taaccttgcc 828481 aatgcccttg gtgcatggat cggcggaatg attttaaacg gaacaggctc ttattcctgg 828541 ctgtttgcag gaggtgcgct tatgaccgca tgcggacttg tgctttctac cttcgcacac 828601 ttatcagaaa agaagagcgt ctacgaatat caagtcaata aagggtaaaa aacagctgca 828661 gtgtatgcag ctgttcttct ttaccgtttg cctgaggctc tcattctttc ttgaggatgc 828721 tgattgatag atccgtcagc acgctttgaa gcatagtcgt cctttgctct cggttcaccc 828781 tgaaatttgt tttcgttttc gtaaggaaat cctttttctt tatttcggac catgtcatat 828841 ccccctaggt tcgagatcaa aaagttgcgt cttttcagat gaagacgtaa ggttagtata 828901 tggagaacac cacgtaataa agcgttattt ttttcctgaa gaaaggagac tgcacacatg 828961 aatatgtaca ttgagaaact gactaatctg cttctggaaa agaacgagat gatcagctat 829021 atacaggcaa aaacgtgggt ggaattgtta tggagcgatt tcgaagcaac ctacgcaaaa 829081 gccggacacg cctatcaagg tgaaaaaatg actgaaaaaa tcgtcacaca atggattgaa 829141 aactatggcg gccagctcca cctttttcaa agctcccgta acgacgtgaa tgattactta 829201 aatcaaagca gaggcctttt gcattaaaaa cctgccgtta acgaccggca ggttttttca 829261 ttttcttaaa attaccttaa caggaagaaa tcataaacaa aacatgtttc accagcctgt 829321 caatcaggga ataccactta tatcttgtca aaatgcgagg aggagcttta tatgaaaaag 829381 aaacaagtaa tgctcgcttt aacagctgcc gcaggactgg gtttgacagc acttcattcc 829441 gctcccgcag caaaagctgc gccccttcac gacatatctg tcagcatgcc atcatccgat 829501 acttacatca taaaagcagg aaagctgaat gtccggactg agccaaatca tgaaggtgat 829561 attctcggca ctgtatcatc agaacaaaag gtaaaagtcg ataggttcgt aaatgccgat 829621 tgggctcaaa ttcatttcaa aggaaagaaa gcatatattt caactcactt tttaatgaaa 829681 accgcaagcc aagcgaaaac aacgaaacag acagccttct atacaccgac gcccgaaaac 829741 ggaaaagcta agcagctctc atctggaaca gaggtgacaa tacttgggtg gggattcagt 829801 gaaaacggcg gatttgactt cacttgggcg ttcgtggatt atggcggagt taaaggctat 829861 attcacacaa aggatttaca aatgcgataa aaaggcaggc cgaggcttgt ctttttgcct 829921 atgcatgaaa catttcttct ttctgcacgt aacaatgaga aaggagatga tgatatgacg 829981 ggtttagtcg gcggagggct tatgatcatt gcgggcatac tgatcaaact gtttcctccc 830041 aaatcgatca acagtgtgta cggatacaga acgagacgct caatgtcaga tcaaagatta 830101 tggaatgaag cgaaccgtta cagtgcatca ttaatgatcc tgtcaggctt ggtgattgcg 830161 ggaatgggtt tgctgctggg atcaaacttg tttattcttc agcttatcct gctgattgcc 830221 gcctgtgtca taacatttat gctaacggag aaaaggctga aaatcatgac gcacagtcaa 830281 ggaggagata gaagtggacg gagttaaatg ccagtttgtc aatacgaacg gaatcacgct 830341 tcacgttgca gccgcaggac gggaagatgg cccgttaatt gtcctgctcc atggatttcc 830401 tgagttttgg tacggctgga aaaatcaaat caaaccgctt gttgatgcgg gttaccgggt 830461 cattgctcct gatcagcggg gctacaatct cagtgacaaa ccggaaggaa ttgattcgta 830521 tcggattgat acattaagag atgatatcat cgggcttatt acgcaattca ctgatgaaaa 830581 agcaattgtc atcggtcatg actggggagg agctgtcgca tggcatttgg cttccacacg 830641 cccggaatat cttgaaaaac tgatcgcgat caatatcccg cacccgcacg tcatgaaaac 830701 cgtaacgccg ctttatccgc cgcaatggct gaaaagctcg tatatcgcat acttccagct 830761 gcccgatata ccggaggcat cactaaggga aaatgattat gatacattag acaaagcgat 830821 tggattatcc gaccgtcccg cgctttttac atccgaggat gtcagcaggt acaaagaagc 830881 gtggaagcag ccgggcgcgc tgacagctat gctgaactgg tacagagccc tcagaaaagg 830941 aagcttggca gagaaaccct cttacgaaac agtaccttac cgaatgatct ggggaatgga 831001 agaccgcttt ttgagcagaa agcttgcgaa agagacggaa aggcattgcc cgaatggaca 831061 tctcatcttt gttgatgaag cttcccattg gattaaccac gaaaagccag ccatcgtcaa 831121 tcagctgatt ttggaatatc ttaagaacca ataagctaaa atttctctcc atccgtctgt 831181 cataatggca gactttttct gtgcgttttt tttcatagtc tgttttaaac atgacaaaat 831241 aacattaaaa atcatgaatg tcaccataaa attgtaacaa aaaacaggtt taaacgactt 831301 taaaaaaagg aatagcctta ctgaagattt gtgtaaaact cccctaaggc aatacttaaa 831361 aagaataata aaaagaaggt gccttaatga agcaaggatt aatctcgatt attatcccgt 831421 cttacaatga agggtataat gttaaactca ttcatgaatc tttaaaaaag gaatttaaaa 831481 acattcatta tgactatgaa atattcttca taaacgacgg aagtgttgat gacacgcttc 831541 agcagatcaa agacttggca gcgacgtgca gccgggtaaa atatatatct ttttctcgaa 831601 actttggaaa agaagccgca attttggcgg gctttgagca tgttcagggc gaggcggtta 831661 ttgtcatgga tgccgatctg cagcatccga catatttgct gaaggaattt atcaaaggct 831721 acgaagaagg gtatgaccaa gtcattgccc aaaggaacag aaaaggggac agctttgtcc 831781 gctcactctt atcatctatg tattacaagt tcattaataa agcggtggaa gtcgatttgc 831841 gtgacggtgt cggtgacttc agattgttaa gccgccaagc tgtgaatgca cttttgaagc 831901 tgagcgaagg aaaccgcttc tcaaaaggcc ttttttgctg gattggcttt gatcagaaaa 831961 ttgtatttta tgaaaatgtc gaacgaaaaa acggcacctc caaatggtcg ttcagcagtc 832021 tgtttaacta cggaatggac ggcgtcgttt catttaatca taagccgctg agattatgtt 832081 tttatacagg cattttcatc ctgctgcttt ccatcattta tatcattgcc acattcgtta 832141 aaattctgac taacggtatt tctgtgcctg ggtatttcac cattatctca gcagtgttat 832201 ttctcggcgg agtacagctg ttaagtcttg gaataatagg tgaatatatc ggccgaatct 832261 attatgaaac aaaaaaacgc ccgcattatt tgatcaaaga ggcgaatatc ccgaacaaag 832321 acctgcctga aacgaacgaa ttaaaaagca tgcggcgtct gacaaaaatg cactgaaaat 832381 accaagcgcc attggcagtg ctttttttgc gtgtctatta tcttaaaagc aagactggag 832441 aattcatatg aaaagaaaac atatcatgat ctatgcggcc agtttgctgg tgtccgttct 832501 ggcacacgct ttttttgtga aagaatgggc ggaaggcagg tatatgacag gtccgggtga 832561 cgggcttgcg caaatgatcg tatttaaaaa attattattt gaccaatata cacacgggaa 832621 ttttttctac aattattcat tcggacttgg cggcggcaca ttcagtcagc tcggctatta 832681 tttttctgcg tcttttcttt ttcttgctgt gtctgccgct gtttggctgc ttcaagccgt 832741 ccagctgatc ggagaaacgg atacgctttt ttgggcagag tcagctgttt ttatcagtat 832801 tttcaaattg agcttgatca tctttacgtc cgcttctgtt tttcattatc ttcttaagca 832861 cagggcggca tcgttcacgg gagccgtgtt atacggcgtc tcaattattt atttccgtca 832921 cgaagcgtat tgggaatttt tcaccgatac aatggtttgg cttccgctgc ttgtgcttgg 832981 cgcagaaaaa attattagag agcggcgtcc ggcgtggttt atcgttgcgt gttcgctgac 833041 gttaatcaac aatttttact ttgcatacat aaaccttata ttcatcggaa tctatgtgct 833101 gttcagatgg ctgatccgtt tggaaccaca tgaagagaaa agatggattc aaatcagatt 833161 atttctcgtt tcaggcttca tttcttttgg catcagtgcg gcggcgtttg tgccggtagt 833221 atacggtttt ttaaacaacc tgcgccctcc atacagccag aaaatagagt ggctcaattt 833281 cgatgataat atcttatttt cgagccggat catcattgtg ccggccgctt ttctgctgtt 833341 tttgtttatt atttcttttt acaaaaaccg tgtgtttcgt ctctttgccg ggttgagcct 833401 gctgtttatt ctgtttcatt tcagtccgta tgcggcaagc gtctttaacg gtttttccgc 833461 cccgcaaaac cggtttgaat atgttctggc ctttaccatt gcgggagcag ctgcggctgg 833521 tttgtcacag ctgtctgaat tgaaacggaa agaactgctc ccggccgcag ctgtcgtcct 833581 gcttctttac ttgtatcata tccaaaggta taagctcgat atatggaagc ctgcgaatga 833641 aagtattcta ttgctcttac tcatgacaat cgcagccttg tttgctgcag cttttgcgaa 833701 aaaacgggca aaaatggctg tgtacggtat aatcattctt tcttcgctgt ttgtcgccaa 833761 ctcctatcaa aaatacgcgc tctcagaagg cggcgatttg gacagtgtga caaaagaata 833821 tcttacaagt gaggaataca gagggcggga atcatctgag ctcatcagac gtttacagaa 833881 ggaagacgat gacccgctca tgagaatcga ctggatgaac ggggtccgca ataatacgcc 833941 aatcatttac ggatttaatg gcttcagcgc gtattccagc attttaaaca aagatctgct 834001 ggccttctat tggaatgatt taagcatcga tatgggcagg gaaagcgtca gccgttacgc 834061 gtcattggga gacagggcga atttatacag cctgctttac ggcaaatatt atatgaccga 834121 aaaaacaaac gaagccagcg tcccgtacgg cttcaaaaag catttagaaa cagagcatta 834181 tgcagtttat gagaatcagt acatgcttcc attcgttaaa acagcggatg ccatatacag 834241 cgaaagtgag ctggaccgat tgcccgctct tgcgaaagaa caggcgatgc tgaaaggaat 834301 tatattaaaa gatccatcag gaaaaacgga gcagacacca aaaccgtcca atttgatcac 834361 caagtcggac atcaccgcaa aacaagccca gtatcaaaac gggctgctaa ccgtaactgg 834421 agaaaacgga ggagagctga tcatcacccc gaaacagcca tcatccgctc cgggagacta 834481 ctatgtcagc ttttatttga aaagcaaagc aaaagacaaa ggatttacat taaaggtaaa 834541 tgattatgtc acaacaagga aatcgaacaa atcgatctat aaaaccggag taaataatat 834601 aacggtaaga gtgcctaaat caggccatat ctcaatcaat cttccgaaag gaacctatga 834661 gctgagaaac atagcgctct atgaagaaaa ttaccaaacg ctgaaaaacg ctgtaatgca 834721 aaataaaaca gagaaagcag acaaactgaa ttggaacaaa aatcgactga ccttttccta 834781 tcatctgtca aaagaccagt acatcatgct tccgatccca tatgaaaaag gctgggagct 834841 gaagatcaac ggaaaaacac agaagatcga aaaagcggat tatgctttta taggcttcaa 834901 ggcgcaaaag ggagacaatc acattgagct gacttactat ccgccatact tcaaaatatc 834961 ggcgatcata tctctcgtca gtctgctgct tgctgttttt tatataagac gtaaaaagcc 835021 cggctctata tagagccgag ctttaatttt ttctgaagtt tttcttcgct gaatatccat 835081 cccgtatagg atgaacgaat cgtgagatca tggccgatat gaacaattgc gacaaacgga 835141 taatggcctt tgctccgata acgcaggtcg ataaatctca cctcataatg atctttaaac 835201 gtatccactt cccaccggta taccggagaa aaggacagaa acgccgcgat gttatcatcc 835261 tgctttgccg catgcattac atcggtttca ggaacaggca cccgattaaa tgtatccaga 835321 atcacgacat gtccttccat gcttcttcct acatagaaag catgtgctgt cgtcactgcg 835381 attcgccatt gcctgaattt catcgttgga gaaataataa tgctttcgat ctcatcatga 835441 atcatctcat gaagcttccg tttaattctc agctgcatga tcaggcgcac caagtagtag 835501 cctaccaata tgatatataa gctgagaaac gtgatgccgg gactcccgcc tgcataccaa 835561 atcgcgatag ctgccagatg gctgataaaa ataaacggat caaacgtatt aatcagcccg 835621 agcgcaaccc attttttcga aaacggacga atggcttgtg ttccataggc gttgaatata 835681 tcaacaaaga catgcagaac gactgccagc agtgtccaca gccacaggtg cagaaaatcg 835741 gcctgaggat aaaataaata cagaatcgcc gggatgatga cagaccaaaa caaaacggcg 835801 ggaattgaat gggtaaatcc tctgtgattc cttatataaa cagcattgtt tttaagcttt 835861 aacacagtat caatatccgg agcctgagag cccgcaagcg ttgcgatcat aacagcgtga 835921 gccattgccg gatctgatcc gacaacagga tcaagcgtcg caataccgcc cagtgcgatg 835981 cccataacga catgtgtgcc cgtatccata ggtgacctcc ttgcagggtg atcctgcaca 836041 ttcactttgt aagaaattcc ccattttcat atacccaatt tttaaactga ttcaatcgtt 836101 ctcatatgtt tccgcttttt ctttattact atttaatgta acatattatc gtactgtgcc 836161 cttagtgtac aacaaaaaac agtctaaaga aaagcggggc gcgaaagact ggggagaaac 836221 acatatgaac gtacttgaag acaaattaaa acaaaaagac atacagcaat ttcgcgatga 836281 tttaatctca tggtttgaac gagagcagcg cgttttgccg tggagagagg accaagatcc 836341 atataaggtg tgggtatctg aagtgatgct gcagcaaacg agagtagaga cagtgattcc 836401 ttactttctc cggtttgtag aacaattccc gacagtggaa gcgctcgctg atgctgatga 836461 agaaaaggtg ctgaaagcat gggaagggct cggctattat tcgcgagtca gaaacctgca 836521 aagcgcggta aaagaagtga aacaggaata cggcggcatt gttcctccag acgagaaaga 836581 ttttggcggg ttaaaaggcg tcggccctta tacaaaggga gcggtgctca gcattgccta 836641 caataaaccc attcccgcgg ttgacggaaa tgtgatgcgt gtcatgtcca ggattctatc 836701 tatttgggat gatattgcca aaccaaaaac aagaacgatc tttgaagacg ccatacgagc 836761 ttttatttcc aaagaaaaac catctgaatt taatcagggc ttgatggagc ttggagcctt 836821 gatctgtacg ccaaaatcac cctcatgcct gctttgcccg gttcagcagc attgctcagc 836881 atttgaagaa ggcactgaac gggagcttcc ggtaaaaagc aaaaagaaaa agcccgggat 836941 caaaaccatg gccgcgatcg tactgactga tgaagacgga caagtgtata tccacaaacg 837001 gccgtctaaa ggtttgctcg ccaacctgtg ggaattcccg aatcttgaaa cacaaaaagg 837061 gatcaaaact gagcgtgaac agctcattgc tttcttagaa aacgaatatg gcatacaagc 837121 tgatatcagt gatctgcaag gtgtagtcga gcatgttttc acccacctgg tatggaatat 837181 ttcagtgttt ttcggtaaag taaaacaagt gtcggatacc agcaagctga aaaaagtaac 837241 gaaagaagag ctcgaacaat ttgcgttccc ggtgtcacat caaaaaatct ggaagatggc 837301 aggagaagca gccgccatct cggctgctcc gtaaaccatt cttaatcgta agagacgcgc 837361 gtgccgtggc tgtagtccgc ttcattgcgc ttcattccgc cgcgcgcttc aatttcttgc 837421 gttaattccc ggtattttga ttggccttct tcgttcaaat aaggcataat ttgctgaaag 837481 gcatgatgaa aataagcgag ttcactgttc ttccaatctt ttttggaaac catgttcaat 837541 tcgctcatat cacgtccgac atacataaca gaagaccccc tttaaagttc ttgccattat 837601 tgtttgtgga aataaaagaa ctatacgcta caaggagatg aggaaaaatg gaacaaaata 837661 aatgtgcact cgtaacagga agcagccgcg gtgtcggaaa agcggccgcg atcagacttg 837721 ctgagaacgg ctataacatc gtcattaact atgcacgcag caaaaaagca gcattagaaa 837781 cagcggaaga aatcgaaaag cttggcgtta aagtgcttgt cgtaaaagca aacgtaggac 837841 agcctgcaaa aatcaaagaa atgtttcagc aaattgatga aacgttcggc agacttgatg 837901 tttttgtcaa taatgccgct tcaggagtac taagacctgt catggaatta gaagaaacac 837961 actgggactg gacgatgaac attaatgcga aagcattgct tttctgcgct caggaagctg 838021 ccaagctaat ggagaagaac ggtggcgggc atattgtcag cattagttca ttaggctcta 838081 tccgctatct tgaaaactac accacggtcg gtgtatcaaa agcagcgtta gaggctttaa 838141 cccgttatct tgccgttgag ctttcaccaa aacaaattat cgtcaatgct gtttcaggcg 838201 gagcgatcga cacagatgcg ctgaagcact tcccgaatag agaagatctg cttgaggatg 838261 cgcgccaaaa tacgccggcg ggacgcatgg tcgaaattaa agacatggtt gatactgtgg 838321 agtttctagt gtcttccaag gctgacatga tccgcggaca gacaattatc gttgacggcg 838381 gacgctcact gctcgtttaa aaatttttaa aaaagaggaa tagctatacg atcacctgca 838441 cattctaatg accgtggagg tgataacaat ggctaactca aataacttca gcaaaacaaa 838501 cgctcaacaa gttagaaaac aaaaccaaca atcagctgct ggtcaaggtc aatttggcac 838561 tgaatttgct agcgaaacaa acgctcagca agtcagaaaa caaaaccagc aatcagctgg 838621 acaacaaggt caattcggca ctgaattcgc tagtgaaact gacgcacagc aggtaagaca 838681 gcaaaaccaa tctgctgaac aaaacaaaca acaaaacagc taatcactga aacagaaaaa 838741 agcacttcat cttcgggtgg aagtgctttt ttctgtttga aaaacgacaa aacttgtgga 838801 aggtctacag aatgagtcaa agggtttgct ttatggagat cgaaatgatt aaaggaggaa 838861 atgtttatac tttcatcagg ctgaaggagg aaccgatgac cgaatttgaa aagctggtaa 838921 gtgaacagat gaaaacgatg gataagcttc tcgatctcca atcagagctc gaccgctgca 838981 aacaaattga ggcggaactc cggcatttgg aaagggatgc aaggctgcgt gggattcagg 839041 ctgaaattgc ggtaaaacgg aaacaccttg ccgatataca ggatatgttt caaaagcaga 839101 cagagcaggt cattcgttca tatcgcagct cagaaaagcc gtcttccttt gtgtagtgca 839161 ggaatgtgcc attccccggc cggaatggct cttttatttt catttttcaa tttgtaacgt 839221 tataataggt aaaagacgtt gtcggtaagc aaatttggac atactaactg tagggcttta 839281 tagaaagtag gggagaaata tgggctatcc caaggaagga gaaaccattc aaattcacag 839341 ctataagcac aacgggctga ttcatagaat ttggaatgag acaacaatct taaaaagtac 839401 agaaatgtgt gtcatcggag ccaatgaccg gacgatggta accgaatcag acggccggac 839461 atggataacc agagagcccg caatctgtta ttttcacgca agacaatggt ttaatgtcat 839521 cgggatgctg agggaagacg gggttcatta ttattgcaac atcagttctc cgtttgccta 839581 tgatggcgaa gcaattaaat atattgatta tgacttagat gttaaggttt ttcctgacat 839641 gacctacaat attctcgatg aagacgaata tgatgatcat cggaaagcca tgaattatcc 839701 aaaagaaatc gacagtattt taagagacta cttaaatacg ctgctccatt ggattcacca 839761 gcgtcaggga ccgtttgcgc ccgagtttgt cgatatgtgg tatgaacggt atttgcgcta 839821 tacaaaataa tggttacgta aaaacctgtt gcggggtaca acaggttttt cacatgggct 839881 cacacacatc atgataaaga gagaggggga atcaaccgtg ggggttatga aacgctacat 839941 gcaattcgtc aaaccttata agaagcaaat tttcgttaca gtgttaatcg ggatcgtaaa 840001 attctccatt ccgcttgctc tcccattgct tctgaagtac gtagttgacg acattattca 840061 aggaggcggc acggccagtg acaaaaccac gtcattgttc acgattatgg cgatcatgtt 840121 cgccttattt ttaattttgc gcccgcctgt tgaatattac cggcaatatt ttgcccagtg 840181 gactgccagc aaggtgcttt atgatataag agctaagctg tttgaccata tacaaaaact 840241 gagccttcgt ttttacgcga atacaagaac aggggaagtc atttcccgag tgattaatga 840301 tgtagaacaa acaaaggatt tcgtcatcac agggctgatg aatatatggc tcgatatgct 840361 gacgattttg attgtaatct ctatcatgct cacactggac gttaaattaa cgctgatctc 840421 tatcgtttta ttcccattat acggaatatc agtgaagtat ttttacggcc gtttacgaaa 840481 gctgacaagg gagcgctcac aggctcttgc tcaagtgcag gggcatttgc atgaacgcat 840541 tcaaggcatg cctgtcatca gaagctttgc gatagaagat catgaacagg ctcaatttaa 840601 tgagaaaaac ggtcatttct tagataaagc catccgccac acgaattgga acgcgaaaac 840661 ctttgcggtc gttaatacca ttacagattt ggcgccgctc atcgtcatag cgtgcgccgg 840721 gtattttgtc attaatggac cgctgacagt cggaacaatg gtcgcgtttg tcggatatat 840781 tgacagaatg tacaaccctg ttagaaggct gatcaattcc tctacaactt tgacacagtc 840841 aatcgcatca atggacaggg tgtttgaatt tattgacgag ccctatgaac tcactgacaa 840901 accaaatgcg ataaaggccg atcagattcg cggaggagtg gagtttcaaa acgtttcgtt 840961 tcaatatgag aaggacaaag aaaatattct tcatgatgta tccttaaaag taaatagagg 841021 agaaactgta gctctcgtcg gcatgagcgg aggaggaaaa tcaacgctcg tcagcctgat 841081 cccaagattt tatgatgtaa caagcggcag actgctgatt gatgggacgg atattcgcga 841141 ttatgaagca agaagccttc gcaaccaggt tggtatggtg cttcaagata cctttttatt 841201 tagtgaaacg attcgggaaa atatcgcgat cggcaagcct gatgccacac ttgaagagat 841261 aatcgaagcc gccaaagctg caaatgccca tgaatttatc atgagttttc cagaaggata 841321 tgagacccgg gtgggggaac gaggcgttaa gctttcaggc ggacaaaagc agcggatctc 841381 aattgcgcgg gtattcctga aaaatccgcc gctcctcatt ttagatgaag ctacatcagc 841441 tctggatttg gaaagtgagc attacattca agaagcgatg gacaaactgg cgaaggatag 841501 aacaactttt gttgtcgccc accgtttatc gacaatcacc catgcggata agattgttgt 841561 catggaaaac gggacaatca ttgaaatcgg aacccatgat gaactcatgg actatgagag 841621 ccaatacaag cacttattta ccattcaaaa tttgaactaa aacatcaatc ttatatcctt 841681 ttaacgaagg atataagatt tttttgtata taaaaaaacc cggctgttta accgggttac 841741 tcttctgttt ctatttcgca gtctttcgga tgatacgttt gaaaacttgt gataagtgtt 841801 tctaaatgtt caagctgctc gcgatattcc acggcgcttg ccataatatt gagcatgttg 841861 taatcaataa gctcctcatc cgtattctgc tgatttttta aaaatgactt tgttaaaagc 841921 tgcttatacc ggatgccttc ttcaaccgcg tcatcatgcg gcttgatttt tccgacaaac 841981 ctcatcaaaa tccgctcgtg ccagtaaagc aggtaatcaa gttcttcagt caatgtttcc 842041 tgaaactctt ccggcatatg atagatctcg ttttccagac gatgcagctt cttcaatgta 842101 tcaagcgccc gatttgcagt aataatggcc tgtctgaaca ggacaagctt tcttgatttc 842161 acataagtcg ttttcttaaa gtaacttctt tcttctttat atagaagata tgtctgatca 842221 agcttgatca ttttttcttt cagtttttca atatcctctt tcaaaatcga atgctctgtc 842281 gactgccgca tggacaatct gatccacttc ataatttctt cggtgttttc gacggtatta 842341 tgaatcagct ttgtttcgta cttaggaggc aaaaacacaa ggttgacgat aaaggaagaa 842401 agcaccccta agatgactgt gcttgttctg atcagcgcga acattaaaaa gtcgtcaccg 842461 gcagattcta atatcgcaat gactgttaca agagcaattg aaattgtatg ttcaatttta 842521 agtttcagca tgattgtaat gacaataact gctgttaacc cgatcataat cgggctgggt 842581 ccgaaaataa ggccgaacac tgtggcaatc acagctccga tgatatttgc ttgaacctgg 842641 tcaataataa tgagaaaaga gcggtaaatc gacggctgga tcgcaaatat cgctgcaatt 842701 ccagcgaaaa tcggcgcggg aagcccgatc cacgaagcca aataaagggc aagtgtaatc 842761 gcaatcccgg ttttgaaaat gcgggcacca agtttcattg gtttgtgcgt gcattccttt 842821 ctatagtaaa ttgtgtgaca tagcaaatgg gctaatcctt aaaattcccg gttagtttat 842881 ttgctaaaca attaagtaat atacagggat cgatacaaat attcaagcta tttttctaga 842941 aaaagaccaa aatcttacac gctgtttgat tccataaaaa aacaggagct caaagctcct 843001 gttcaaggta tttgattcta gttttttaga tgtttaaatg catcctcgac cgctgtaagc 843061 gtgtctttaa tatcctgctc tgtatgtgct gtggtaataa accaagcttc atacttagaa 843121 ggtgctaaat taattccgcg ttccagcatc agcttgaaaa acgtagagaa tgtttctccg 843181 tcactccgtt cagcctgctc gtaattttcc actttctcat cagagaagta taccgtgagc 843241 gcacctttta accggttgac cgtaatggtg atgccgtgtg tttctgcgtg cttcaaaatg 843301 ccttcctcaa gcatagcgcc aaggtgatca agcttttcat acacgccttt ttctttgagc 843361 acttccagac aagcgatgcc tgataggatg gaagcggggt tccctgccat tgttcctgcc 843421 tgataagcag gccctagcgg agctacctgc tccatgattt cttgtttgcc gccataggcc 843481 ccaatcggaa gtccgccgcc gataattttc ccgagtgctg ttaaatctgg tttcacctgt 843541 aagagatcct gcgcgccgcc atacataaag cggaaagccg taatgacttc atcgtaaata 843601 acgagagccc ctgcattatg tgttaattca tttacttgtt ctaagaagcc ctctttcggc 843661 tccacgatac cgaagttgcc gacaatcggt tcaacgagaa ccgccgcgat ttcactgccc 843721 catttttcaa gagctgcttt atagctatcg atatcattaa atggtactgt gatcacttcg 843781 tttgcaatgc ttttcggtac accggctgag tctggtgtgc cgagagtaga cgggccggag 843841 cctgcggcga caagcacaag gtccgaatgc ccgtgatagc agcccgcaaa tttaatgatt 843901 tttgtccggc ctgtatatgc gcgagccacg cggatggtcg tcataacggc ttctgtaccc 843961 gaattgacga atcttacttt gtccatagcg ggaatggctt ctttgagcat ttttgcaaat 844021 gtaacctcgt gtttcgttgg tgttccatac aatacaccgt tctctgctgc ttttttaatc 844081 gcttctgtaa tatgcggatg ggcatgtcct gtaataatcg gaccgtacgc cgctaaataa 844141 tcgatgtatt tgttgccgtc cacatcccaa aaataagcgc cgcttgcttt ctccattgca 844201 acaggagaac cgccgccgac tgctttatat gatctagacg ggctgtttac accgccgaca 844261 atgtgctgta atgcctcatt gtgaagttca attgattttg tatgcaagaa taaaaacctc 844321 ctatatctcc atgcgtcctt tctattgtag catgcttccg aacaagaaca atggcttcgg 844381 gcttcagatt cagctgagat ggttgtaatc tggacaagaa ttggatacgc ttaataaaaa 844441 aacatccgga ggtaacgtaa tgactataga aatcggacaa aaagcgcctg atcttgagtt 844501 aaaaggtgat catggggaaa cagtaaaatt atcggattat aaaggaaagt acatcgtgct 844561 ttatttttat ccaaaggaca tgacaccggg atgtacaact gaagcatgcg attttcggga 844621 cagtcacgaa agcttcgccg aactggatgc cgtcattatc ggcgtcagcc cggacagcca 844681 ggaaaaacac ggaaaattta aagagaagca taaccttcca tttctgcttc ttgttgatga 844741 cgagcataag ctggcggaag catttgatgt gtggaagctg aagaaaaact tcggaaaaga 844801 gtatatggga atcgagcgtt ccactttttt aattgataaa gaaggccggc tcattaaaga 844861 atggagaaaa gtaaaagtaa aggaccatgt agccgaagcg cttcaaaccc tcaaagatat 844921 gtctgaaaag taaatctcta tgagcctatg cttactttta ccctgatatc aattgacaaa 844981 ttatcgtaga aagagttaca ctaattataa acattacaat gtaagaattt tttttagaag 845041 agaggtgcat gacggatggc tgcacatgaa ctaaaagaag ccttagaaac gttgaaggaa 845101 accggagttc gcattactcc tcaacgtcat gcgattctgg aatatctcgt taactctatg 845161 gctcatccaa cagcggacga tatatataaa gctctggaag ggaaatttcc taacatgagc 845221 gtagcgacgg tatataacaa tttgcgtgtg ttccgggaat caggtttggt aaaagagctc 845281 acatacggtg atgcttccag cagattcgat tttgtcacat ccgatcacta tcacgcgatt 845341 tgcgaaaact gcggtaaaat tgtggacttc cactacccgg gccttgatga agtggagcag 845401 ctcgctgccc acgtcacggg cttcaaggta agccaccacc gtttagaaat ttacggcgtc 845461 tgccaagagt gttcgaaaaa agaaaatcat taaaaataag ctgaccgcac gaaacggtca 845521 gcttatttta tttcgacatt ttctttttat tataagactc atcaaattct tttccttcta 845581 atcccttatc taaagtcagc ggctctcggc aatgcatgca catatcgact actcctaaaa 845641 cctttgtctc tttatcacag cctggacaaa tgacgcgaac cgctttagtc gaaagcattc 845701 cgatccaaaa gtaaactacc gtgctgagac cgatggataa aagcccaagt atcataaaca 845761 aactagaaag caaaactgac tctttgaaaa agatcccgat gtacataatg ataaacccaa 845821 cgaaaaccaa acttaacgca aatgttctga ttttattaat tttgctggag tatttcgcca 845881 tgtccatccc cctctgtttt aactatagca caaacccgat gggattttct tcatgttttc 845941 ggttgaactg gaatttacat atggagagtt actgtgaaat tgtttataat agttcaatgt 846001 gtttagaaaa aaggaatttc gttttaacca tagaattgaa tcaaatagag aataaaaaaa 846061 tttgaacaat tgcattggag gaatagtgat ggaaaatctt ctccgtccaa tttaccaaga 846121 aagagcaagt caccccaata cattggctgt cattatgatt gagagaagaa acaaaacatc 846181 ttccttaaca gataactttg atgcagcttt gctggtgatt gtaaaggatg ctgatgagcc 846241 agtttttata aagcattatg aatttgatca tcaaacagct tctttgcatg tggtaacaga 846301 ttctcagatt caagaatgga ttttgcttgg aacaaataga agaatcatag attggattgt 846361 aaatggcaga gtcttgtttg accgtaatga atacgtagtt gaactgattg acaggctgaa 846421 tacatttccg tttgccgaac gtaaactgaa gatcggactc gaatacggca aattaatcag 846481 aaggtatgtt gaagggaaag ctttttttga agccaatcaa tttttagatg cctacaatgc 846541 cgttgttcat gcgctgcatc atttagcacg tattgaagta atcgacagag gattccatcc 846601 cgaaaccacg gtgtggagcc aagtgcgcca gatggagccc caagtgtaca aattatattc 846661 cgagctgatt gaaagtcatg agagcctgga aaaaagactt gaattattat tcttagcaaa 846721 tgattttctc atccattcca aagccgagat cggttcggcg catcttttcg aagtaatgaa 846781 agaaaaagac atttggcaat tcggtgagct tcttcaacat catgacctaa agcactttac 846841 ccaagatctt ggcgttatgc ttgattactt gacggaaaag ggacttatca acgtctgcca 846901 gatagaaacg aaaggacagg ctgtctatca ccgaggatat tcttttaaaa aaggtgttga 846961 ctctgattct tgaccgtgtt atattattaa acgtcgctga tgcgcttctg agaaaacaag 847021 ctcacagcgg cgggaaaata aatcaaaaaa acatttgaca aaagaaagtc aaaatgttat 847081 attaataaag tcgcttcaac aagaagtgaa aatgatcttt gaaaactaaa caagacaaaa 847141 cgtacctgtt aattcagttt ttaaaaaatc gcacagcgat gtgcgtagtc agtcaaacta 847201 gggcctgcac gacgcaggtc acacaggtgt cgccgcagga tgcggtgaac ttaacctgtg 847261 atccatttat cggagagttt gatcctggct caggacgaac gctggcggcg tgcctaatac 847321 atgcaagtcg agcggacaga tgggagcttg ctccctgatg ttagcggcgg acgggtgagt 847381 aacacgtggg taacctgcct gtaagactgg gataactccg ggaaaccggg gctaataccg 847441 gatggttgtt tgaaccgcat ggttcaaaca taaaaggtgg cttcggctac cacttacaga 847501 tggacccgcg gcgcattagc tagttggtga ggtaacggct caccaaggca acgatgcgta 847561 gccgacctga gagggtgatc ggccacactg ggactgagac acggcccaga ctcctacggg 847621 aggcagcagt agggaatctt ccgcaatgga cgaaagtctg acggagcaac gccgcgtgag 847681 tgatgaaggt tttcggatcg taaagctctg ttgttaggga agaacaagta ccgttcgaat 847741 agggcggtac cttgacggta cctaaccaga aagccacggc taactacgtg ccagcagccg 847801 cggtaatacg taggtggcaa gcgttgtccg gaattattgg gcgtaaaggg ctcgcaggcg 847861 gtttcttaag tctgatgtga aagcccccgg ctcaaccggg gagggtcatt ggaaactggg 847921 gaacttgagt gcagaagagg agagtggaat tccacgtgta gcggtgaaat gcgtagagat 847981 gtggaggaac accagtggcg aaggcgactc tctggtctgt aactgacgct gaggagcgaa 848041 agcgtgggga gcgaacagga ttagataccc tggtagtcca cgccgtaaac gatgagtgct 848101 aagtgttagg gggtttccgc cccttagtgc tgcagctaac gcattaagca ctccgcctgg 848161 ggagtacggt cgcaagactg aaactcaaag gaattgacgg gggcccgcac aagcggtgga 848221 gcatgtggtt taattcgaag caacgcgaag aaccttacca ggtcttgaca tcctctgaca 848281 atcctagaga taggacgtcc ccttcggggg cagagtgaca ggtggtgcat ggttgtcgtc 848341 agctcgtgtc gtgagatgtt gggttaagtc ccgcaacgag cgcaaccctt gatcttagtt 848401 gccagcattc agttgggcac tctaaggtga ctgccggtga caaaccggag gaaggtgggg 848461 atgacgtcaa atcatcatgc cccttatgac ctgggctaca cacgtgctac aatggacaga 848521 acaaagggca gcgaaaccgc gaggttaagc caatcccaca aatctgttct cagttcggat 848581 cgcagtctgc aactcgactg cgtgaagctg gaatcgctag taatcgcgga tcagcatgcc 848641 gcggtgaata cgttcccggg ccttgtacac accgcccgtc acaccacgag agtttgtaac 848701 acccgaagtc ggtgaggtaa ccttttagga gccagccgcc gaaggtggga cagatgattg 848761 gggtgaagtc gtaacaaggt agccgtatcg gaaggtgcgg ctggatcacc tcctttctaa 848821 ggatattata cggaatataa gaccttgggt cttataaaca gaacgttccc tgtcttgttt 848881 agttttgaag gatcattcct tcgaaacgtg ttctttgaaa actagataac agtagacatc 848941 acattcaatt agtaatacaa gatatcacat agtgattctt tttaacggtt aagttagaaa 849001 gggcgcacgg tggatgcctt ggcactagga gccgatgaag gacgggacga acaccgatat 849061 gcttcgggga gctgtaagca agctttgatc cggagatttc cgaatgggga aacccaccac 849121 tcgtaatgga gtggtatcca tatctgaatt cataggatat gagaaggcag acccggggaa 849181 ctgaaacatc taagtacccg gaggaagaga aagcaaatgc gattccctga gtagcggcga 849241 gcgaaacggg attagcccaa accaagaggc ttgcctcttg gggttgtagg acactctgta 849301 cggagttaca aaagaacgag gtagatgaag aggtctggaa aggcccgcca taggaggtaa 849361 cagccctgta gtcaaaactt cgttctctcc tgagtggatc ctgagtacgg cggaacacgt 849421 gaaattccgt cggaatccgg gaggaccatc tcccaaggct aaatactccc tagtgaccga 849481 tagtgaacca gtaccgtgag ggaaaggtga aaagcacccc ggaaggggag tgaaagagat 849541 cctgaaaccg tgtgcctaca agtagtcaga gcccgttaac gggtgatggc gtgccttttg 849601 tagaatgaac cggcgagtta cgatcccgtg caaggttaag cagaagatgc ggagccgcag 849661 cgaaagcgag tctgaatagg gcgcatgagt acgtggtcgt agacccgaaa ccaggtgatc 849721 tacccatgtc cagggtgaag ttcaggtaac actgaatgga ggcccgaacc cacgcacgtt 849781 gaaaagtgcg gggatgaggt gtgggtaggg gtgaaatgcc aatcgaacct ggagatagct 849841 ggttctctcc gaaatagctt tagggctagc ctcaaggtaa gagtcttgga ggtagagcac 849901 tgattggact aggggcccct accgggttac cgaattcagt caaactccga atgccaatga 849961 cttatccttg ggagtcagac tgcgagtgat aagatccgta gtcgaaaggg aaacagccca 850021 gaccgccagc taaggtccca aagtatacgt taagtggaaa aggatgtgga gttgcttaga 850081 caaccaggat gttggcttag aagcagccac catttaaaga gtgcgtaata gctcactggt 850141 cgagtgactc tgcgccgaaa atgtaccggg gctaaacgta tcaccgaagc tgcggactgt 850201 tcttcgaaca gtggtaggag agcgttctaa gggctgtgaa gccagaccgg aaggactggt 850261 ggagcgctta gaagtgagaa tgccggtatg agtagcgaaa gaggggtgag aatcccctcc 850321 accgaatgcc taaggtttcc tgaggaaggc tcgtccgctc agggttagtc gggacctaag 850381 ccgaggccga aaggcgtagg cgatggacaa caggttgata ttcctgtacc acctcctcac 850441 catttgagca atggggggac gcaggaggat agggtaagcg cggtattgga tatccgcgtc 850501 caagcagtta ggctgggaaa taggcaaatc cgtttcccat aaggctgagc tgtgatggcg 850561 agcgaaatat agtagcgaag ttcctgattc cacactgcca agaaaagcct ctagcgaggt 850621 gagaggtgcc cgtaccgcaa accgacacag gtaggcgagg agagaatcct aaggtgatcg 850681 agagaactct cgttaaggaa ctcggcaaaa tgaccccgta acttcgggag aaggggtgct 850741 ctgttagggt gcaagcccga gagagccgca gtgaataggc ccaggcgact gtttagcaaa 850801 aacacaggtc tctgcgaagc cgtaaggcga agtatagggg ctgacgcctg cccggtgctg 850861 gaaggttaag aggagcgctt agcgtaagcg aaggtgcgaa ttgaagcccc agtaaacggc 850921 ggccgtaact ataacggtcc taaggtagcg aaattccttg tcgggtaagt tccgacccgc 850981 acgaaaggcg caacgatctg ggcactgtct caacgagaga ctcggtgaaa ttatagtacc 851041 tgtgaagatg caggttaccc gcgacaggac ggaaagaccc cgtggagctt tactgcagcc 851101 tgatattgaa tgttggtaca gcttgtacag gataggtagg agccttggaa accggagcgc 851161 cagcttcggt ggaggcatcg gtgggatact accctggctg tattgacctt ctaacccgcc 851221 gcccttatcg ggcggggaga cagtgtcagg tgggcagttt gactggggcg gtcgcctcct 851281 aaaaggtaac ggaggcgccc aaaggttccc tcagaatggt tggaaatcat tcgcagagtg 851341 taaaggcaca agggagcttg actgcgagac ctacaagtcg agcagggacg aaagtcgggc 851401 ttagtgatcc ggtggttccg catggaaggg ccatcgctca acggataaaa gctaccccgg 851461 ggataacagg cttatctccc ccaagagtcc acatcgacgg ggaggtttgg cacctcgatg 851521 tcggctcatc gcatcctggg gctgtagtcg gtcccaaggg ttgggctgtt cgcccattaa 851581 agcggtacgc gagctgggtt cagaacgtcg tgagacagtt cggtccctat ccgtcgcggg 851641 cgcaggaaat ttgagaggag ctgtccttag tacgagagga ccgggatgga cgcaccgctg 851701 gtgtaccagt tgttctgcca agggcatcgc tgggtagcta tgtgcggacg ggataagtgc 851761 tgaaagcatc taagcatgaa gcccccctca agatgagatt tcccattccg caaggaagta 851821 agatccctga aagatgatca ggttgatagg tctgaggtgg aagtgtggcg acacatggag 851881 ctgacagata ctaatcgatc gagggcttaa ccatattttt gaatgatgtc acacctgtta 851941 tctagttttg agagaataag tttttcaaaa aaacacttga ttttctcaag aatacatagt 852001 ataatgttaa atgtcactga aattgtctgg tgatgatggc gaagaggtca cacccgttcc 852061 catgccgaac acggaagtta agctcttcag cgccgatggt agtcgggggt ttccccctgt 852121 gagagtagga catcgccagg cagacttcat tccgcagtag ctcagtggta gagctatcgg 852181 ctgttaaccg atcggtcgta ggttcgaatc ctacctgcgg agccattatt ggagagctgt 852241 ccgagtggtc gaaggagcac gattggaaat cgtgtaggcg gtcaactccg tctcaagggt 852301 tcgaatccct tgctctccgc cactgatact tatacataat tacaattgaa agtctgggcc 852361 cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt cgaatcccgt 852421 acgggtcatt atatgatgga ggattagctc agctgggaga gcatctgcct tacaagcaga 852481 gggtcggcgg ttcgagcccg tcatcctcca ccattatatc atcgcggggt ggagcagttc 852541 ggtagctcgt cgggctcata acccgaaggt cgcaggttca aatcctgccc ccgcaaccaa 852601 attttaaaat ggtccggtag ttcagttggt tagaatgcct gcctgtcacg caggaggtcg 852661 cgggttcgag tcccgtccgg accgccattt gaatacttag gctcggtagc tcagttggta 852721 gagcaacgga ctgaaaatcc gtgtgtcggc ggttcgattc cgtcccgagc caccacctat 852781 gccggtgtag ctcaattggt agagcaactg acttgtaatc agtaggttgg gggttcaagt 852841 cctcttgccg gcactgtttt ttcaaaattt aatgtggagg ggtagcgaag tggctaaacg 852901 cggcggactg taaatccgct ccctcagggt tcggcagttc gaatctgccc ccctccacca 852961 tttatagggg catagtttaa cggtagaaca gaggtctcca aaacctccgg tgtgggttcg 853021 attcctactg cccctgccaa atttatgaca tcttgagatt atggcggttg tggcgaagtg 853081 gttaacgcac cagattgtgg ctctggcact cgtgggttcg attcccatca atcgccccat 853141 attatcattg ggctatagcc aagcggtaag gcaacggact ttgactccgt catgcgttgg 853201 ttcgaatcca gctagcccag tctcactttt tatatcaact gcatataatg tattaagtcc 853261 attaaaaatg cggaagtagt tcagtggtag aacaccacct tgccaaggtg ggggtcgcgg 853321 gttcgaatcc cgtcttccgc tccaattacg gcggcatagc caagtggtaa ggcagaggtc 853381 tgcaaaacct ttatccccgg ttcgaatccg ggtgtcgcct tcttattgcc ggggtggtgg 853441 aattggcaga cacacaggac ttaaaatcct gcggtaggtg actaccgtgc cggttcaagt 853501 ccggccctcg gcaccaattt tacttacatg gtaagttgaa ttggtgtttg tgttttatca 853561 ttataactaa tcatattaat gatctacata agtagatcat ttttttaatg ctttgattta 853621 tcataacaag ttaagttccg aggcctatta taaagcggct gtatagctag tctttcaaca 853681 cttttatttt atatttccat aaaaactttt ttgaaatacg ttgacacttt atgagatcca 853741 tgatatattt atattcgtcg gttagatacg acgtaaaact tgccggtgtg gcggaattgg 853801 cagacgcgca cgactcaaaa tcgtgttcct tctggagtgt cggttcgacc ccgaccaccg 853861 gtatactgaa aaacccgttt cttaacagaa acgggttttt attttttatt aaagaaaagg 853921 agcctcggct cctttttata cttactcagc gtattggtct aggatctctt ctagcacctc 853981 ttctagctct tctgtatctt caagctctga ttggctgaaa cggacgcgta caagctgttc 854041 tccgtcatta tacatctctt ccaaccaccc tcggagtcct cttgctctgc ggtcgacttc 854101 gaaaatgatt tccaaaccgt cttcgtctaa aaggaaaatg agctctaatt catcaagcat 854161 ctgacgataa tatccggaag tcggaacgaa ttcgaattct tgaacgaacg gaagacgacg 854221 ctggaagtag ggcgcttgtt cgcagtctgc ttcgttaaga cggaagccca ggttttcgat 854281 tgcttcaagc acattttcaa tccaagggtg cgcttcaacg aaaatgcggt catgatcgga 854341 tttatcgata ccgccttgaa tgtcaaggtc tgtcaccacg gcaacctcta ctttccctac 854401 agtgatcggc gtatctagag gcagagtgaa tgtgaacgga aattgatgct cttcaccagg 854461 ctgtatggta aatgaaccag tgacccggaa agaatgaatt gtagcgtatt tccggtgctc 854521 ttcatcgtct tttacaatga cataccgtgt gctaagctgt aaatcgatat aacggatgtc 854581 ctgagcgatt tttccgcctt tgacatgtac cgttccctgt acttcttctc ctggaaaata 854641 tgcgtctttt tctaaaattg tatctacttt tgcagctcca attccggcac ttgccgcaag 854701 cttcttaaaa aatgacatgt tagatcttcc cctttttctt ttttctcaac agatatacgt 854761 aagaaggagg aaaaaagatt cgtttgattc atactttttt cctattattc gtctcggcct 854821 agggacagac taagaataat attgaaaata aaggagtcga tggaagtgaa taaagaaagt 854881 ttggttgcag atgaattaca cagaatgttt ttggctggtg agctgcaaat cacagtagag 854941 gaggatataa acaatatttc cgaaaggctg agaaacggcg atctcagttt agaccgatta 855001 agcggtgaag acgtgtttat aaaagaaacg gtaaatgagg ctttaagaag agtggagcaa 855061 taaaaaagag acggcatctc atctttgaga tcccgtctct ttttgtggtc tttgctgtaa 855121 gataaaagcg aatcgatttg gaattgctca cccgagccac cccttttcta acagaagatc 855181 tgacagttca tcatggagat aaacagctgt atctaattga tcatgcaatg ctcttctgat 855241 gtggggattt tcggttgctg ttgttgcgac agtgtatttg ttaatgctgg tttttattgt 855301 tgttaacaaa tcaagaatat ctttgggaca aagactttgt tcaatgggaa accacctcct 855361 ttgttttttt agcagctcct gataagaaag tatttgactt tgtttcttgc ttctatacaa 855421 aatgctataa taagcaacaa attttgttgg ggggtgtgat gatgaagcag attattgcga 855481 tggggggcgg gggtttttcg atggagccgg ataatttgtc cctcgatcaa tatatcctca 855541 atcaatcaaa acgagagcag cctcgtattt gttttttgcc gacggcgagc ggagattccc 855601 aaaactatat tcagcggttt tatcatgcat ttcaaacatt ggattgcgtg ccgtctcatt 855661 tatctttgtt taagccacca tcatcagatt tagtttcttt tgttatggaa atggacgtga 855721 tttatgttgg cgggggaaat acgcggaatt tacttgtgtt atggaaagag tgggggctgg 855781 accatattct cagggaagca tggaagaacg gtgtggttgt agctggaata agtgccggtg 855841 cgatctgctg gtttgaagaa ggggtgacag attcagccgg accgctgaca agtttgaaaa 855901 gtttaggttt tttgcaaggg agcttttgtc cccattatga cggggaaaag gatcggagac 855961 cggcatacca ccagctgata tctaacaagt tcttatgcag tggctatgca gcggatgatg 856021 gggctgctct ccatttcata aatgatcagc tgtttcagac tgtgagttca aggtcgggtg 856081 caaaggcata tcgggtgatg atggctgaac atgaaatagc tgaaatcccg ttgccggtca 856141 aatatttagg gtgaaattgg ctgaatatta tctatattcc tctttttttc agattgattt 856201 tatgataaga tgagtgcgaa atcaatagtt actgggggtg cccgctttcg ggctgagaga 856261 gaaggcaagc ttcttaaccc tttggacctg atctggttcg taccagcgtg gggaagtaga 856321 ggaattgttt ttgttattgt cttgctgggc aataatatgt ttctttctga ctgtaaccgg 856381 gttcatttat atgaatccgg ttttttgtgc tggttatggg cttgattttg tcctttcaaa 856441 cgtagaaagg ggaaggaaaa gtaatgcaaa acaattcagt gcagcaagcc aacatttcca 856501 ttatgtcaag tttttcaggc agcaagaagg tatacgtgga gggttcttct tcggacatcc 856561 aagtgccgat gagggagatt gcattgagtc cgacgacggg atcgttcggc gaagaggaaa 856621 acgcgcctgt gcgtgtctat gatacaagcg gaccgtatac ggaccctgaa gtaaccatta 856681 atattcaaga aggattaaag ccgctccgcc aaaaatggat cacagagcgc ggtgacgtgg 856741 aagagtatga aggtcgggct ataaaaccag aagataacgg ttataaaaaa gcaaaaccaa 856801 acgtaagcta tccaggatta aagcggaaac cgctgagggc gaaggcaggt caaaatgtca 856861 cacaaatgca ctatgcaaaa aaggggatca ttacacctga gatggaattt atcgccattc 856921 gtgagcatgt gtctcctgaa ttcgtcagag acgaggtagc cagcggccgg gcgattattc 856981 cttcaaacat taatcaccct gaaagtgagc caatgattat cggccggaat tttcatgtga 857041 agattaatgc aaatatcggg aattcagcgg ttacgtcatc cattgaagaa gaagtggaaa 857101 aaatgacgtg ggccatccgc tggggagcgg atacgatgat ggatctctct accggaaaag 857161 atattcatac gacgcgtgaa tggattatcc gcaattgccc cgtgcctgtg ggaactgttc 857221 cgatttatca ggcgcttgaa aaagtaaacg gcgtagctga ggatttaacg tgggagattt 857281 atcgtgatac gctaatcgag caggcagagc agggagtgga ttattttacg attcacgcgg 857341 gtgttttgct taggtatgta ccgctgactg ccaaacggac aactggtatc gtgtcacgcg 857401 ggggagcgat tatggcgcag tggtgtctgg ctcatcatca agaaagcttt ttatacacac 857461 attttgaaga aatatgtgag attatgaaaa tgtatgatat tgctttctct cttggggatg 857521 gtttgcgtcc cggatcaatt gctgatgcca atgacgaagc gcagtttgct gaattagaga 857581 cgcttggaga gctgacgcaa attgcctgga agcatgatgt tcaggtgatg attgagggtc 857641 ctggacatgt tccgatgcat aaaatcaaag agaacgtcga taaacaaatg gacatttgta 857701 aagaagcgcc tttttacaca ttggggccgt tgacaacgga tattgctccg ggatatgacc 857761 atattacttc agcgatcgga gcggcgatga tcggttggta cgggacagca atgctttgtt 857821 atgtaacgcc gaaggagcat ttggggctgc caaaccgtga tgatgttcgt gaaggagtca 857881 ttacatataa gatcgctgcg cacgctgcgg accttgcaaa agggcatccc ggagcgcaaa 857941 tccgggatga tgcgttatcg aaagcccgtt ttgaattccg ctggcgggat cagtttaatt 858001 tatctcttga tccggagaga gcccttgaat accatgatga aaccctgcct gctgaaggag 858061 caaaaaccgc tcacttttgt tccatgtgcg gtccgaaatt ttgcagcatg agaatttcac 858121 aggatattcg ggattatgcg aagaaaaacg atctcagtga agcagaagcc ataaataaag 858181 gattaaaaga aaaagcaaaa gagtttgtcg atacgggaag caatttatat caataaaaaa 858241 aatgaagatg gagaatgctc catcttcatt tttttagaaa aacagagagc gtcgaagcgg 858301 aggaatactc tgttcaaagc ggaaaacatt ttctggatca tatgtcgttt tgacacggcg 858361 gagtcgttca acgttttcgc cgtaatatgt tcttggccag tttctgattt cgatatctgg 858421 ccaatttacg tagtctccca tcgtttcttt cgaaagggac gttctcagcc cctcaatcca 858481 gcggacattt tgtctttttt ctccagggga tgtccagttt gttaagtatt cctgggcgat 858541 gattgcgtca cgataataaa atgccgtttg gtcgggagcg acccgtccgg ctgccccgcc 858601 gagtgcttgc tgccagacac tggcgttttg attcggagcg tgctctaaaa agtgttttat 858661 tgttgagatc gcacgttctg ataatggctt ttcaatgaaa gagccggagc gtttcatttt 858721 ttgaggctga ttgcctcccg ggctgttaaa aaaggttacc gcttcaatga atggcgttgt 858781 ttttaccatt ccgcttgtcg gacttcctgc tttcaataaa ggctttaaca gtttttttaa 858841 ctctgttttt ggcccgacaa attggccgag ggcttctatg cggtttactt ctttaggcca 858901 aaactctatt gatgatgtaa gccggtcatc tgtatacggg gcccagttct gccacgtgtt 858961 atatacttcc tcaaaatcat cccatcccca tgtaatagaa aaaatcgaca cttgagagat 859021 gggcactgct ttaaatgtca tggaggtgac tatgccgaaa ttgcctcctc cgcctccctg 859081 agacgcccaa aataagtctg gatgatttga acagctgact gtaatcagat cagcgccctc 859141 tttttcgtct gctacgatca tctcaagctg cacgaggctg tcgcaagtaa gaccggcagc 859201 ccttgttaaa agtccaattc cccctccgag agttaaacct gtgagcccta cattagcaat 859261 ggtgcctgcg ggaagcgtca ggccgtattg ccagagtgtc cgatagactt ctcccaattc 859321 agcccccgct tcaatatagg ccagcttttt atcctgattc acagttattt ttttcatctc 859381 gcttaaatca ataacaagac cgttatttaa aagggaaaag ttctcatagc tgtgtctgcc 859441 gcctctaata cggaaaggca cacggttttc acgcgcccat ttcagcgcat tgagtgcatc 859501 ctgtttgttt tggcaaaaca caatgatgtc aggatacctt tctaagctta ggttaatatt 859561 ggttcttgct tcgttatagt ccggatcatc ccgtgtcacg atacgtccgg tcaattttgt 859621 cttttccaca ctcccacatc tctttctctc gtattctagt ttctctagct tatgcgtcag 859681 gggaaaagag tgtataagga aaaagcgggg atgcaatctg atacagtgtc aacaccctca 859741 aaaaatagtt gacaggtcgg tattgtatga attaacatgg tcagtacaaa tttttcaaat 859801 ttatcgcgct gatcggaaca ccgaaggctc ttatcgttta gataagggcc ttttttgtat 859861 gaaaaagggg ggattattga tgggagtcaa aaaagaaaag gggagaaaac gattcaggaa 859921 gcgaaaaacc tacgggaatc agattttgcc gcttgagctg ctgattgaaa aaaacaaacg 859981 agagattata aacagcgcgg aactcatgga agaaatttat atgaagattg atgagaagca 860041 tacgcaatgt gtaactaaat ataaaaaaac ccgctgacta caacgggttt ttgcatttct 860101 ccattaagaa tcttttttaa tcggcaatcc aaggccttct gccacgcgtt ttccgtattc 860161 aggatccgct ttgtagaagt gctcgatttg gcgcagcttg atttcttctt tttctaccgg 860221 cttcatggca ttaacgatat tttcaacaag gcgggtacgt tcatcttcac tcattaaacg 860281 atacagatcg ccggcttgag tgtagtgatc gtagtgatcg tagcttacgc tgtcagcgat 860341 accttgtacc ggatatgctg cttgcttatc ctcaggtgac tcttttggac cgccgaagct 860401 gttaggctcg taatacacag atccgccgcc gttatcatca aaacgcattt gcccatcacg 860461 ctgataattg tttactttgt tgcgtgcgcg gttgattggc agcgcttgat ggtttgcacc 860521 gacacggtag cggtgtgcat catgataagc aaaaagtcga ccttgaagca ttttatccgg 860581 tgaaacatca ataccaggca cgagggttcc aggtgaaaat gtcgcttgtt ctacctctgc 860641 aaagtagttt tccggatttc tgtctagaac catgcgtccg acctcgatta acgggtagtc 860701 tttttgagac caaacttttg tgacatcaaa cggatcgaaa cggtacgtat ttgcatcttc 860761 taaaggcatg atttgcacat atagtttcca tgcaggataa tcaccgtttt cgattgcgtt 860821 gaaaaggtct tctgtatggt aatcagggtt ttcaccggca atttttgctg ccgtattgac 860881 atcaaggttt ttcacgcctt gttctgtttt aaagtgatat ttaatccata cgccttcgcc 860941 ttcggcattt gtccatttga atgtatggct tccgaagccg tgcatgtggc gaagtgtcgc 861001 aggaattccg cggtcagaca tcaggattgt cacttggtgc agtgactctg gtgaaagtga 861061 ccagaaatcc catacagccg tagggttttt caggtgtgtt tttggatctc ttttttgtgt 861121 atggatgaaa tcagggaact taatcgcatc gcggataaag aatacaggcg tattgttgcc 861181 gacgatgtcg tagtttcctt cttcagtata aaatttaaca gcaaatccgc gcgggtcgcg 861241 aactgtgtca gcagagccaa gttcaccggc aactgttgag aaacggatga acaacggtgt 861301 gcgtttgccg acttcagaaa ggaaagcggc tttcgtgtat tttgttacgt cgtttgtcac 861361 ttcaaaatat ccgtgtgcgc ctgctccttt ggcgtgaaca acacgttcag gaacacgttc 861421 tcggttgaaa tgggccaatt tttcgagtaa atgtacatct tgaattaaag ttggtccgcg 861481 agaaccggca gtcattgagt tttgattatc tccaaccgga gcgccccagc tagttgtcag 861541 tttatttgaa ctcatgttat cacctcttgg aatttataag aacataatat catctctaag 861601 taaaaagtca atattatttt ataattatta taaaatagtt atctctatta atcgatatat 861661 agtatcgaaa ttgttgaaaa accttgttgt aacagctttt tatgacactt aataattttt 861721 ggagaaataa tttttccttc tctatttgcg aaacaagcag agtaagtgat aaacaaggat 861781 atcaaaaatc gtatttaaaa aagagttgac atatcggaat aatttgaatt aacatgttat 861841 tcaaacaaaa aaacaattgg gcagctgatc ggaccgccga aggctctcat ctctacaaga 861901 acagagatgg gggccttttt gttttttttg aaggcggggt tggcagaaag agagggataa 861961 aagtggctgt gaccatcagc atcaaagaaa aggcatttgt tcaagaaggc cgcaaaaaca 862021 cggtcttaga aaacatagaa ttatcaatcg caccaggcga atttctaacg cttatcggac 862081 cgagcgggtg cggaaaaagc accctgttaa agattattgc agggcttgat tctgaatatg 862141 acgggagtgt ggaaattaac ggccgcagcg taacagctcc gggtattcag caaggattta 862201 tttttcagga acaccgcctc tttccttggc tgactgttga gcagaatatt gcagccgact 862261 tgaatttgaa ggacccaaaa gtcaaacaaa aggtggatga actgatcgag attgtcagat 862321 tgaaaggatc ggaaaaagca tatccgcgcg agctgtcagg cggcatgtca caaagagtag 862381 ccatcgcccg ggccctgctg cgggagcctg aggtgctgct tttagatgaa ccgtttggtg 862441 cactcgacgc ttttacaaga aaacacctgc aggacgtgct gctggatata tggaggaaga 862501 aaaaaacaac gatgattctc gtgactcatg atatagatga atctgtttat ttaggaaatg 862561 agcttgcgat ccttaaggcc aaaccgggga aaatccataa gctgatgccc attcacctgg 862621 cgtatccgcg aaaccggacg actccggatt tccaagcgat cagacagaga gtgctgtcgg 862681 aattcgagaa aacagaagat ttggagtacg cagaaggatc agggatatag aaagggcgga 862741 agcggaaatg aaaaaaggac tcattgtatt ggttgccgtt atttttctgc tcgcaggctg 862801 tggagcaaat ggagccagcg gtgaccacaa acaattgaag gaaattcgta ttggtattca 862861 gcaaagctta agcccccttt tgattgcaaa agaaaaaggc tggttcgaag atgcatttga 862921 aaaagaaggc atcaaagtga aatgggtgga gtttcaaagc ggtccgcccc aatttgaagg 862981 ccttgcggca gacaaacttg atttttctca agtcggtaat tcgcctgtga tcgctggaca 863041 ggcggcaggc attgacttta aagaaatcgg tttgtctcag gacggcttga aagcaaacgg 863101 catccttgtc aatcaaaaca gcggcattca agacgttaag ggcttaaagg ggaagaaaat 863161 tgcagtcgcc aaaggcagca gcgggtttga ttttttgtat aaagcgcttg atcaagtggg 863221 gttgtcagct aacgatgtga caattattca gcttcagcct gatgaagcag cttccgcatt 863281 tgaaaacgga tctgttgatg cctggtccat ttgggagccg tacttgtcct tagaaacaat 863341 gaaacacgga gcaaaaatcc ttgtgaacgg agaaagcaca gatttatatt caccgggttt 863401 tactttagta agaacaaagt tttcagaaga gcatccagac gaagtggtcc gttttctgaa 863461 ggtgtttaat aaagccgttg tatggcaaaa ggaacatctg gatgaagcag cggacttata 863521 ttctgacatt aaagatctcg ataaaaaggt cgtcgaaaat gtgctgaaaa atactgagcc 863581 acttaatgag atcatcagtg acgacattgt gaaagcacag caggaaacag cagattttca 863641 atttcgaaca aaggcgatag ataagaagat tgatgtgaag gatgttgtcg ataacacttt 863701 tatcaaaaaa gcattagagg agcattcctc aggaggtgat caatgatgaa agcagaggct 863761 gcgggctcgc tgcccaaaac gaatgcggaa gcggtgcgaa aaaagcccgg aaggaagaga 863821 tacggctgga tgaaggggct tttactgccc gctgtcatca ttgccatctg gcaggtcatc 863881 ggcgggctgg gggttgtgtc cgctacagtg ctgcctacac ctgttacgat tgttctgacc 863941 tttaaggagc ttattttgtc cggcgaactg ttcggccatc tgcaaatcag catttatcgg 864001 gcggcacttg gttttttgct tggcgcgggg cttggattga tgatcgggat tttggccgga 864061 ttttccaaac ggacggagct gtatcttgat ccgtcgttgc aaatgcttag aaccgtacct 864121 catctggccg tcacgccgct gtttatttta tggttcggat ttgacgaagt atctaaaatt 864181 ttgctgattg cgctcggtgc cttctttcct gtctatatca atacgtttaa cggcatccgc 864241 ggggttgacg cgaagctgtt tgaagtcgcc cgggtgcttg aatttaaatg gcatcagcag 864301 atatccaaag tgatattgcc ggcagccctg cccaatatat tgctaggcat tcgcttatcg 864361 ctcggcattg catggctcgg gctcgttgtg gcagagctga tgggctcaag ctcgggagtc 864421 ggctatatga tcatggatgc gagacagttt tcacaaacga ataaagtctt tgcagggatt 864481 atcatttttg cagtggttgg aaagctgacg gattccttcg tcaggctgct tgaacgaaag 864541 ctgttaaagt ggagaaacag ctacgaagga taaaagatat aaaggggaga tgaatatgga 864601 aattctttgg tttataccga ctcatggaga cgcgagatat ttaggatctg aaagtgatgg 864661 acggactgcg gatcatcttt actttaaaca agtcgcgcag gcggcagaca ggctgggata 864721 tacaggagtt cttctgccaa cgggaagatc gtgcgaggac ccgtggctta cagcgtcggc 864781 actggcagga gaaacaaagg acttaaagtt tttagtcgcg gtaagacctg gtttaatgca 864841 gccttctctg gcagccagaa tgacatccac cctagaccgc atttcagacg gccggctgct 864901 gatcaacgtt gtggcagggg gcgatccgta tgagctggca ggcgatggcc tgtttatcag 864961 ccatgatgag cgctacgagg caacagacga atttttaacc gtttggcgga gacttttgca 865021 gggagaaacg gtttcctatg aaggaaagca tataaaagtg gaaaacagca atctgctttt 865081 cccgccgcag caagagccgc atccgcccat ctatttcggt ggttcgtcac aggctggaat 865141 tgaagctgcc gcaaagcata cagacgtgta cttgacatgg ggtgagccgc ctgaacaagt 865201 aaaagaaaag atagaaagag tcaaaaagca agcggcaaaa gaagggagat ccgttcgatt 865261 tggcattagg ctgcatgtca ttgcccgtga aactgaacaa gaggcatggg aagcggcaga 865321 gcgcttgatc agccacttgg atgatgacac cattgccaaa gcgcaggcag ctttgagccg 865381 ttacgactct tcaggccagc agcggatggc cgtccttcat caaggcgatc ggacgaagct 865441 tgaaatcagc ccgaatctgt gggcggggat cggcctggtc agaggagggg caggaacagc 865501 tcttgtcggt gatccgcaga cgattgccga ccggatagcg gagtaccagg cactcggcat 865561 agaatcgttt atattctccg gctatccgca tttagaagaa gcgtattatt ttgcagagct 865621 tgtatttccg cttttgccgt ttgaaaatga tcggacgaga aagcttcaga acaaaagggg 865681 agaagcggta ggaaacactt attttgtcaa agagaaaaat gcatgagttt aactaaaata 865741 cagccccccg aacatggtat gatattcaaa aaaagggggc tttttttctg aaaacattga 865801 gaagcgcggc agtcatttgc ctcatagcta tgctgtcagc atgcggacat tcaaaacaga 865861 tggaaatcaa agcggcggac atatcagatc ttgaaaaaaa cagaatggat gtcgcagctt 865921 cacaggcatt cactgccgaa gccgtcaata tcggtgaagg tatttcttca gctgacatgt 865981 acatcgaaca ttatcaaaag ggaaagcttg ttgagaggtt tggaccggtt cgtgcagatt 866041 attcagagga aaaaactgat accatacaat ttgtttattt tgagaatgaa gagggggaag 866101 gaaagaataa acataccacc attcattttg gcattgtgga taaacaggga actatagcgg 866161 ctgattcatc ggtgaaacgc gacgatagca caacacagga aatgactcag aatatttcat 866221 cgccggaacc gattactttc gagaagcctg ctttgatcgg cagcagtatt agagggactg 866281 acgagacaat gcacacctct gaacataaaa aagagctcat taagcatcaa gatgcgttac 866341 tgtattatgt ggaattgcat cattagaatg ggcggcttca ggccgtctgt tttacaaagc 866401 ggtatgcttg cttttttgaa tggtgaatga tacattttaa atcgtaacaa tttcgattta 866461 aagggaggct atgtgacttg gctaaaaaat caaaagtggc aaaagagtta aaacgccaac 866521 agcttgttga gcaatacgct ggtattagac gcgagttgaa ggaaaaagga gattacgagg 866581 cactcagcaa gctgccaaga gattcagcac cgggaaggct tcacaaccgc tgcatggtaa 866641 cggggcgccc gagagcatat atgaggaagt ttaaaatgtc cagaatcgct ttcagggagc 866701 tggcccataa aggccagatt cccggtgtga aaaaagcaag ctggtaagaa aaaactccgg 866761 ccgattacag cgcgccggag tttttttcgt ttttcttgaa agagatgacg taggaaaggt 866821 gctggatgat catgatgata aacacaataa taatagggaa aaacggaatg cgcgattgaa 866881 atagcggata aaaaatgaga agaaccgctg cggcaggcag cgagaagtag acagcgatat 866941 atgacgcgcg acatgctttt gccgtcatca tctgctctct ttcatcctgc tcttcaaact 867001 catcaggcag aagtagctgc tttctggcag ggcggctttt tttctgtaag tacaaataaa 867061 ccgcagacgc cgcaacaaac agaataaagg gagtgaggtt taaatcaaat accatcccgc 867121 cgctctttgt gccgaaaaaa gatgctatgc cttctgaggc ttcaaagtat gaaatcagcg 867181 cccagcatgc aaggccaaat aaaacaaggt gaaaagctgc ttttgttttc atgctcatct 867241 tagttttcct cctctaacca aaagacatcc tccattttca tggagaaggc tttgcagatt 867301 ttcagtgcta acagcagtga gggaacataa tcgccttttt caatcgctgc cacagtctgt 867361 cttgtgacgc cgaccgtttc tccgagtttt tcctgagaat agccgaagcg tgccctcagc 867421 tcttttactt tatttttcat catgacgtct gtccccttca caatctcgat tgattatatt 867481 gtatagtata cttaacatta tgtaaatgga acttaacaac tttacaaaaa gataactttt 867541 tttcgacaaa atttttatat tcccttgacg aaaaataaat aaacatgtaa tataaaaaaa 867601 gtcagagcgg tactgttgct gacaatcaca aatgcgggtg tagtttagtg gtaaaacctc 867661 agccttccaa gctgatgtcg tgagttcgat tctcatcacc cgctccatac atacgttatt 867721 aacgcagtgt ttcgtttctc agataaacga agtattgcgt ttttttatgt gaaaaagaac 867781 acggtattcg tgttctttta cgtaagccaa tgtactgtat gggtgccgcc gtgaatttgt 867841 tcaaacattt tcgttaatga tgataagagg ttaacagcgc tgcttttctc aatcgatggc 867901 gggaaaaaaa tgatttgcag catattctta gtctcgtttg aaacgggata gtggttgacg 867961 ctgtttttga aatcgccaaa aatgccgttt tcatcagaga aaagcagtat gttttctttt 868021 tctcccaatg agatccggac cggctcatga agctttccgg catcataaat cataataggc 868081 agagaatatt ttaatgcgaa aaaatcgatt gtgtcatggg ccgagtcttt actttccatg 868141 aattgttcct tggatatcgg gaccagcatg tcctccattg gggttgtttc tccctcaaat 868201 gaagggttaa gctgtttaaa gagtttctgc cattccttga cgaaggattc atcggatata 868261 ccgccgtccg catagtcgaa aaacaaggat tcttgaaaca ggcggagtct gcctttcagc 868321 atttgcggtg aggagccgac ttcgatattc tcataaatga cagcagctgc atgtaagccg 868381 gccgcacgtt cagtaataac agaatcaagt ttgatattca ctagcattca ctccagttac 868441 gtgatatcaa cctattataa acgctgtgtc gttttatcac aaagaaagga ggctgtgcaa 868501 aacatgaacg tttatcagct caaagaagaa ttaattgaat acgcgaaaag cattggcgta 868561 gacaagattg gttttacgac cgctgatact tttgacagtt taaaagaccg tttgattctt 868621 caagaatcac tcggctatct ctccggcttt gaagagccag atatcgaaaa aagggtgacg 868681 ccgaagcttc ttttgccgaa agcgaaatca atagtggcaa ttgctctcgc atatccttcc 868741 agaatgaagg atgcgccgag aagcacgaga actgagcgca ggggcatttt ttgcagagct 868801 tcctggggaa aagactatca tgatgtgctg agggaaaagc ttgatctgct ggaggatttt 868861 ctaaaaagca agcatgagga tatcagaacg aagtcaatgg ttgatacagg tgaattgtct 868921 gatcgcgccg ttgcggaacg tgccggaatc ggattcagtg cgaaaaactg tatgatcaca 868981 acacccgagt atggctctta tgtgtatttg gcggaaatga tcacaaatat cccttttgag 869041 cctgatgtgc cgattgaaga tatgtgcggg tcctgcacga aatgcttgga cgcctgccca 869101 acgggagcac tggttaatcc cgggcagctt aatgcgcagc gctgcatctc ttttctgacc 869161 cagacaaaag gatttttgcc tgatgaattc cggacaaaaa tcggaaaccg cctgtacggg 869221 tgcgatacgt gccaaacggt atgccctctc aataaaggga aggattttca tcttcatccg 869281 gaaatggagc ctgatcctga gattgccaaa ccgttattga agccgctttt ggccatcagc 869341 aatcgggaat ttaaggagaa attcgggcat gtctcaggtt cttggcgcgg aaaaaaaccg 869401 attcagcgaa acgccattct cgcgcttgcc cattttaagg atgcttccgc actgcctgaa 869461 ttgacggaac tgatgcacaa ggatccgcgt cctgtcatca gggggacagc cgcatgggca 869521 atcggaaaaa tcggagaccc cgcctacgcg gaagagcttg aaaaagcgct ggaaaaagag 869581 aaggatgaag aggcaaagct ggaaattgaa aaaggaattg agttgctaaa agcttcaggc 869641 atgactaaac aaggcctgtc ctgacatacg tatagagcag aaggaaaaaa cacttgagat 869701 catccaagtg ttttttctct ataaaaaagt atggcgggtg gggtgagctt gaagtacatt 869761 ttagaacaat tagcggagga gcggctgggc tttctggtta acgggcatgc tatgagacag 869821 gagtctcaag tcggagacct taaagtcatg gagcgtaaga aaaagcttct ggaaaaacgt 869881 aaagttgaca tcataaaagc gaaagcaaag gccgtgatta atcatgtgcg ggttgaggat 869941 gacggaacga cctgcctttc gtataccatc cattacgaat acgtgtgtaa ggaacaagat 870001 gacagcttgt atatagaaga gcacatagag gagcgaatgg ctttcctgta tgatcacatt 870061 ttgattagtg atcaggaaat tgcgaaaaag ccggctggat ttcatgaagg gaccagtatt 870121 attgactatt ctgaagctga agaggaaaga gaagcgtttg gcagggcttt tcaatacgat 870181 cgtctcggcg ctgtccaata tgccgagaaa ttttggaaca agcgcaatcc tgcttataaa 870241 aatttcagcg ataactgtac aaattttatt tctcagtgtc ttcatgcagg aggcgcgccg 870301 atgcgcggtc atccgaacag gggatcaggc tggtggatga aacaaagctc atggagctac 870361 agctggacgg tggctcactc tatgaaaatg tatttgtcga attcaaaggc cggactgcgt 870421 gcggtgcggg tgaaatcagc ggaagaactg atgccgggcg atgtgatttg ctatgacttc 870481 gaaggagacg gccggtttaa tcatacaacg attgtcgtgg caaaggacaa aggcaatatg 870541 ccgcttgtca acgcccagac ttatgacagc aggatgaggt attggtcata tgaggattct 870601 acggcataca cgccgtcaat acgatatgcc ttttttcata tcgttgatga tacgacaaaa 870661 gagtaattaa tgttataatg atgggcggat aagaaaaaca gaggtgaaca ttgtggcatt 870721 acatgtcgtt ttatatcaac cagaaattcc cgctaacaca gggaatattg cacgtacttg 870781 tgcagcaacc aatacaacgc tacacctgat tcgtccgctc ggcttttcaa cggatgataa 870841 aatgctgaag cgtgccggac tcgattattg ggagtttgtt aacgttgtgt atcatgattc 870901 gttagaagaa ttgtttgagg catataaaaa aggcaagttt ttctttatta caaaatttgg 870961 ccagcagcct catacatcat ttgattacac tgatcttgac gaggattatt tcttcgtgtt 871021 cggaagagaa acaagcggtt tgccaaagga tttaattcaa aataatatgg accgctgcct 871081 gcgtcttccg atgacagagc atgtcagatc gttaaatctg tccaatactg ccgcgattct 871141 tgtttatgaa gcgctgcgcc agcaaaatta ccgtgattta aaatagtgaa aaacccgctc 871201 atcgatgatg ggcgggtttt tttgcggatg ttgaaatgct ttgtttcgtt tttgggctta 871261 acaacgtaac agtgttatgt tacaatgtac ccatcaaagg agctggactt atggaagaac 871321 aattaatctc taaaaaagaa ttacttgaaa gaacatcgat ttcatacggt cagctgtatc 871381 gatggaagcg gaaaaactta atacctgagg aatggtttat tcgtaaatcc acatttacag 871441 ggcaagagac gttttttccg agagaggaga ttttaaaacg tatatcaatg attcaaaaga 871501 tgaaagaaaa tttgtctttg gatgaaatga gggaaatgct gtcgccgaaa atgaaggatg 871561 tcagcatgac cgctgatgaa ttgcttcata aaggtttggt ttcaaggcct gctcttgaag 871621 cctattcaga agacggagga agtccggttt tttcatccag cgatttgctt tcgctgtttg 871681 tgcttgaggg cctgctgcag tctggaaatg tcagccttgc agaagcaaaa atggctgcag 871741 aggtattaaa gaagcatgat actgaagaga ttgaaaaaca gacggagctg attgtgctcc 871801 gcaagctcgg tgtcacaact tgttttatag cggctgcggc ggacagcatt ttgtttgaat 871861 catccgtaaa ggttgtggaa cgggtagatt tattaaaagc ttcagaggaa ttaaaaacaa 871921 catttatgca ggagggccat caatggatgt agtggaaaag ctggtgataa atggatcagg 871981 aagttctaag ggaggaacat ttcaatcagt tgagattaat ggcagcggga cagtggccgg 872041 ggacgtggag tgtgacactt tttcttttaa tggaaacgga aaagcggacg gcagcgtcaa 872101 agcgaaagcg gtaactatca gcggttcagg aaagatacat ggagacgttg aagcagaatc 872161 tatccggatg aatggcactg gttttattca aggagaggta tctgcaaaac aattgaaaat 872221 cgctggatca tcaacatttg gcggcactgt caaggctgat ggaattgaca ttagcggaaa 872281 agctgtcatg gaagcagatt gtgaaacaga aacctttcaa tcagaaggga aatgcaaaat 872341 cagcgggctt ttaaatgcag accaggtgat cattaagctt tctgcagggg aaagctatgc 872401 gcgggagatc ggctgccgcc atcttcaagt gacctgcaga aaaggaatgc tgacattgct 872461 cagattgatg ccgcagcctg ttctaacagc agagctgatc gaaggtgacg tgattgaatt 872521 gacaaataca aaggcgaaaa ccgtgcgcgg taataaagtg atcatcggcc cggattgcca 872581 gattgaaacc gtcgaataca gcggggacta tacctgtgat ccaagcgcgt cggttgaaac 872641 atccacaaag ttgtaaggag gatcgtaatg gagacaacaa aactgggaaa tttaaaatta 872701 tatggcgctg ggcatgccgc aggaggcgcg tatcacaatg tcagcatcaa aggagaaggt 872761 atagttggag aagggctgtc tgctgtaggc tgccgcatat acggaacggg cctttttctc 872821 ggaaaagcag agactgagcg gctgcgtgtg ctcggagaaa gtgaatgtaa aggcgatctg 872881 acagccggca aaatcaatat atatgggaca atgaaagtca gcggctcact tcaatttgat 872941 cgattcaatc tgaaaggcca gactgaaatt ggcgggaata tgactggaga atcctgcgat 873001 gtgaaaggga agcttagcgt aataggtgat tgtgaaacag aaatgttcca tgtcacaggc 873061 tgtgttgatg tatcggggtt attaaattcg ggtgagatca agctgggatt gagccatgat 873121 ataagccatg tgcaggaaat cggcggaaca acaattacag tgaaaagacg cgcgagtttt 873181 tttagccgga agaaagggaa gctgatcgcc gatgtcatag aaggagatcg ggtttatttg 873241 gagaataccg aagcggcagt tgtcagggga aaagaagtga tcatcgggcc gggatgcagc 873301 atcggaacga ttgagtacga atacaaatgt gaatgcgatc cgcattcaca gattaaagaa 873361 aaaacaaaac tgtaaaacat tgttctgtta tacaaaaagg gtgctctttc aggagcaccc 873421 ttttttattc ttttccaggc ttgctttcgt atcctgcggt aaaaattgat actaaaaaag 873481 tgacaatgac acccatcatg atgattgttt tcaccgtctc tccccctctt caatttttcc 873541 gtgctgtccg agtctggatg attctgtatt tttctttatt atgaacggtc gcagtctgcc 873601 ttgtcaacga tgtatgagta tctttatttt taagaaacca aagcatgtat cacgagatgg 873661 cggcatagat tgtatcaaag taccttattt gcatagtgta tcaaacatga tagaggaggt 873721 ccttatggat atattaaaga aaattgaaaa gtacagagag gaagagcagc ggctgaaatg 873781 ggaaggaact ttcgccgatt atttggagat tattaaagaa aatccgatgg tcgcgcaatc 873841 tgctcattct cgagttttta atatgataaa agacagcggg atagaggaga ttgacggacg 873901 caagaagtac agtttttttg accgcgagct gttcgggctt gaagaatctc tggagcgtct 873961 tgtggaagag tattttcatc cggctgccaa acgtctagat gtcagaaagc ggattctatt 874021 gctgatgggg cctgtgagcg gcggtaaatc cacgctggtc acaatgctta aaaaaggtct 874081 cgaagcgtac acgctgacag ataatggcgc tgtatatgcg attaaaggct gcccgatgca 874141 cgaggaccct ctacatttaa tcccccatca tttacgcgat gacttttaca gagaatacgg 874201 cattagaata gaaggaagtc tttctccttt aaatgtcatg aggctggagg aagagtacgg 874261 aggaagaatt gaggatgtga aggtggagcg catcttcttt tcagaagata agcgtacggg 874321 aattggaaca ttcagtccct ctgatccgaa atctcaggat attgccgatt tgacggggag 874381 tattgatttc tcaacaatcg ccgagtacgg ttcagaatca gatccgcgcg cttatcgatt 874441 tgacggagag ctgaataaag cgaaccgcgg gatgatggag tttcaggaga tgctgaaatg 874501 tgatgagaaa tttctctggc atttgctttc cttgacacag gaagggaatt ttaaagctgg 874561 gcggtttgcg ttaatttctg ctgatgagct gatcgtggct cacacgaatg aaacggagta 874621 tcgctcattt atttctaata agaagaatga agccctgcac tcaagaatca tcgtgatgcc 874681 ggttccttat aatttaaaag tgtctgagga agagagaatt tatgaaaaaa tgattgcaga 874741 aagcgatgtg gcggatgttc atattgcccc gcatacgttg aaggtcgccg cgatgttctc 874801 aatccttacc cggttaaaag agccgaagcg gtcggatatt gatctggtca agaaaatgag 874861 actgtatgat ggggaaagtg tggaaggata taactctgtc gacgttgagg atatgaaaaa 874921 agaatataat gatgaaggca tgagcggaat tgatccgcgg tacgtgatca accggatttc 874981 ttcaacgatt atcagaaaaa atatggaatc gattaattct ctcgatgtcc ttcgctcctt 875041 aaaagaaggt cttgatcagc acccatcaat ttcaagcgag gacagggagc ggtatttgaa 875101 ttttatctct gccgcccgca aggaatatga cgatattgcg aaaaaggaag ttcaaaaagc 875161 gtttgtttat tcatatgaag aatcagcaaa aacacttatg gacaattacc tcgataacgt 875221 agaggcctat tgcaataaaa acaagcttcg tgatcctttg acaggagagg aaatgaaccc 875281 tgacgaaaag ctgatgagat ccatcgaaga gcagatcggc atttcggaaa acgccaaaaa 875341 agcgttccgc gaagaaattt taatccgcat ctcggcctat gcgagaaaag gcaagcggtt 875401 tgattacaat tcccatgaaa gactgcgtga agctattcag aaaaagctgt ttgctgatct 875461 gaaggatgtc gttaaaatta cgacctcaac aaaaacgccg gatgagcagc agctgaaaaa 875521 ggtaaatgaa gtcgtggccc gtttaattga tgagcacggc tacaactcga cgagcgccaa 875581 tgagctgctg aaatatgtcg gcagcctgct gaaccgataa gcaacgtgac ccgtccgaat 875641 agggcgggtt attttgtccc attttctaaa tagtttgtca attaaacgtg catatgtgca 875701 tatgatgaat ataaatcttt tcaaaagact tgtttcataa tctggcacaa gccggaatac 875761 gtatgtatca cgaccacaaa tggttaagga ggggaattca tgtcccaaaa tgacagcggc 875821 cattttttga tttctgagga aaactggtcc ctccatcgca aaggcttcga tgaccagcag 875881 cgccaccaga aaaaagtgca ggaagcgatc aaaaacaatc ttccggacct cgtaactgag 875941 gaaagcatta ttatgtctaa tggaaaagat gtagtgaaga tcccaatccg ttcacttgat 876001 gagtataaaa tccgttataa ctatgataaa aataaacatg tagggcaagg agacggcgag 876061 agccaggttg gagatgttgt ggcccgggat ggatcagaca aaaaacaagg gcctggaaaa 876121 gggcagggtg ccggtgatca ggcaggcgag gattattatg aagcggaagt ttcattaatg 876181 gatttagaag aagcgctttt taaagaatta gagcttccga atctccagca aaaagagcgg 876241 gacaatatca ttcatacaga tatcgagttt aatgatatcc gtaaaacagg gttaaccggt 876301 aatattgata agaaaagaac gatgatgtca gcctttaaac gaaacgcaat gtcaggaaaa 876361 ccgtcgttct acccaattta tccggaggac ctgaaatata agacgtggaa tgacatcaca 876421 aagcccgaat caaaagccgt cgttttagcc atgatggata caagcggcag tatgggggtt 876481 tgggaaaaat acatggccag aagcttcttt ttctggatga cccgtttttt gcggacaaaa 876541 tacgagactg tggaaattga atttattgcc catcatacag aagcaagagt ggtctcggag 876601 gaggattttt tctcaaaggg agaaagcggc ggaacaattt gttcttccgt atatcggaag 876661 tcgcttgagc ttattgatga aaagtacaat cccgcccgct ataacattta cccgtttcat 876721 ttttctgacg gtgacaacct gacatctgat aacgcgcgct gtgtgaagct ggtcaatgat 876781 attatgaaga aggccaatct gttttgctac ggcgaggtca atcagtacaa caggcattca 876841 acgttaatgt ctgcatataa aaatgtaaaa gatgagaaat ttaagtacta tattttaaaa 876901 cagaaatctg atgtttttca ggctctaaag aactttttca gaaatgaaga gtctggtgta 876961 agccatcaat tttcgtaatg aaaagcccat ttcagggctt ttttttattt aataaaagca 877021 agaaaacgct tgcgaaaaaa atacgggaga aaaagaaatt tttcctttga caaatcttct 877081 ttcatttatt aatattttat cttgtgaact attattgagg aatgaggtga aaaggagttg 877141 actgaatcag aacgtgcttt gctcactttt gaacagctct tcgatacgtc tcgggcgata 877201 tataaaaaac agaagaagat attggagatt gtgcttgagc cttttgatat tacagtcctt 877261 caatatttgc tgatgtttaa aattcatcaa agcggaagca ccccgctaag caagctggca 877321 atgtcgcttg atcttaagcc tgcttctgtg acgcggatga cagatattct gtataagcgc 877381 caattgatga atcgatatga cagtccggat gaccgccgta tcgtcatgat tcagttaacc 877441 gaagaggggg aagaactgat agaaaaagcc gctgtgcaat atgcaaaaat gggtgctggc 877501 ttgtaccaaa agcttgatac ctcccagctg cagtatttgc gcaaactagc cggaagttta 877561 acgaagcttg ctgaaggctg ttcagaaaaa agcggtaatt aaaaacttct cacatatttt 877621 caccagcttt ccgcaaaatg atagaggatg aaacgaaagg agaaaacaaa atgaacagag 877681 gacgtttaat tctgaccaac attatcggtt tgattgttgt tcttgcaatt atagctggag 877741 gtgcttacta ctattatcaa agcacaaact acgtaaaaac agatgaagca aaagtagcgg 877801 gcgatatggc tgctattact gctccagcag caggtaaagt atctgactgg gatctggacg 877861 aaggaaaaac agtgaaaaaa ggcgacacag ttgcaaaaat caaaggtgaa caaactgttg 877921 acgtaaaatc cattatggat ggcacaattg tgaaaaacga agtgaaaaac ggacaaaccg 877981 tacaagctgg tacaacaatt gcacaaacga ttgacatgga caacctatac atcacagcaa 878041 atattaaaga aacagatatt gcggatattg aagtaggaaa tagtgtagac gtagtagttg 878101 acggagaccc tgatactaca tttgacggta ctgtagaaga aattggttat gcgactaact 878161 caacttttga tatgcttcct tctacaaatt caagcggaaa ctacacaaaa gtaacacaaa 878221 aagttcctgt gaaaatttca atcaaaaacc catctgataa ggtgcttcct ggaatgaatg 878281 catctgttaa aatttctgag taaaacagat cagtcatcaa accatgaaag gaggttgtct 878341 tagatggcta caggcaaaga aaaaaatgca aaaaacccta tgtcattgct gattgtgcta 878401 atggcgggtt tatttttggc aattctaaac caaacactgc ttaatgttgc aatgccgcac 878461 ttaatgactg aatttggcgt aagtgcaacg acgattcagt ggctgacaac aggttacatg 878521 cttgttaacg gtgtattgat tccgttatct gctttcctga ttacacgatt tggccagcgg 878581 agtctctttc tcgtcgcgat gttttgtttt acgctcggta cgttagtctg cggtatcgca 878641 cctaacttct ctacaatgct gatcggccgt ttgattcagg ccgtgggcgg aggtatcttg 878701 cagccgctcg ttatgacaac cattctgtta attttcccgc ctgaaagcag ggggaaagga 878761 atggggattt tcgggctagc gatgatgttt gctccagcgg tcggcccgac tctttccggg 878821 tggattattg agcattatac atggcgcatt atgttttacg gacttgtgcc gatcggcgca 878881 attgttatca ttgtggcttt cttcatcttt aaaaatatgg tggagccgca aaaaatcaaa 878941 ctcgatactc ttggcgcaat cctctcgatt gtcggattcg cctccttatt atacggagtc 879001 agtgaagccg gatctgacgg ctggaccgac ccgattgtat tgtctacagt tattatcgga 879061 gccattgcaa ttgttgcttt tgttgttcag caattgcgtc atgatgatcc gatgcttgat 879121 ttcagagtgt ttaaatatga cattttctca ctctcgagtg tcattaatat cattattaca 879181 gtggcacttt acactggtat gttcctttta ccgatttatc tgcaaaacct ggtcggcttt 879241 acggcgcttc aatccggtct gcttctgctt ccgggtgcga tcgttatgct gattatgtca 879301 ccgatctcag gtattttgtt cgataaattc ggaccgagac cgcttgcgat tatcgggctt 879361 ctcgtgacag tggtaacaac gtatcaatac acgcaattga caattgatac accatataca 879421 cacatcatgc tgatctattc aattcgtgca tttggtatgt ctctcttaat gatgccagtc 879481 atgacagccg ggatgaacca gcttcctgcc cgtctgaaca gccacggaac ggcgatgagt 879541 aacacgcttc gccaaatcag cggatcaatc ggaacaagtt taattacgac gatttataca 879601 aaccggacga cattccatta ttcacaaatt gcagataaaa caagcacggc ggacccgaac 879661 ttcctccatg cgttccaaaa tgcagtttcg aatttaatgg tgaatatgaa tgtgtcttat 879721 gatacggcga aaacatatgt gtactcacat atttataaac acgcatcact cgattccaat 879781 gtcatgggga taaatgatgc ctttatgtgg gcaaccttat tctgtgtagc aggtttgatt 879841 ttaagtatct tcctgcgtga cgtcagaaaa gataaattgc gtaagaagaa aaaagaggag 879901 ctttcattac ttcctgctcc aaaagaagct aaggaatctt aatctgtaca gggaggtttc 879961 ctgaatgaaa atttatgtag tgtatgatag tgaaggcgaa catactaaag tgcttgcaga 880021 agcgattgct gaaggcgcga gagaaaacga cgcggctgaa gtgttcatcg accatgtaga 880081 tcaggctgat atccgcaagc ttaaagatat ggatgcgatt atttggggat gcccagggca 880141 tttcggaaca atcagctccg gtcttaaaac ttggatcgac agacttggct acttgtgggc 880201 tgaaggcgag ctgatcaaca aagtcggtgc tgtcttctgc acaacggcaa caacacacgg 880261 cggcttggaa atgacaatgc acaatttaat cacgccgatg ttccaccaag gcatgattgt 880321 tgtcggactg cctggcaacg tgcctgaaaa cgcactttat ggctcttatt acggagcagg 880381 tgtcacttgt ccggtagaca gtgatgagtt aatgtctgag gaaggtattc agcttggacg 880441 cgcgttggga agacgtgtca gccaagtcac aggaaaccta acagcaggac agtaaggaga 880501 ggttgaaatg gccattatta tagcaataat tgctgctgtc attgtcattg cggcccttat 880561 tacatttaac gtccgcaacg cctcacctgg acctgagaag caagaagcaa ccgatagaat 880621 cgcacctcca gaagaggaaa aaaacgaagc gcattaccct gctgaagcaa gggctgccga 880681 gcatacgcca tccgttgtca aaaacgattc tccaaaagag aagcgtgaca caatgggtga 880741 tgatatttac aggcaggcgc tgcaaaagtt taagcattct gatgaagttc atgcagaaga 880801 agaggtcact gaggaaagtg acaaaatgca ggaccgcagc tatcgtgatg cgctgctctc 880861 tatgaaaaat aagaaaaagt aatgaaaaag gcaaatccgt ttactcatgc gggtttgcct 880921 tttttgctgt ttccatcaat tatgttttta tcaaataaat ccatggaata tgttgtattc 880981 caccttgatc tagtgtacta tgttactcat acaccgagga ttttttccgg gaggtaaaga 881041 catgaattct tttttaggtt tattaaagaa agatatcaag ctttcaagaa tgtggctgct 881101 agtatggata tgcggaatca ttttcttatt gggaacaggc catattatag cttctcgcac 881161 gaaagaacct ctagtcattt ttggtttttt tgttgcagtt gctttttttc tgcttttctt 881221 atctcctgtt tttgtttttt atcaccttcg caaggaaggg aaatcacagc tttggctgta 881281 caatccaaat ggcggcttat ggctgttttc ttctaaattg gcagcatctt tgctctatca 881341 atttgtgatt cagttggcat taacagccta tggcatatgg atgtatcata tgctctctgt 881401 aaaaaatctg ctggagcatc aagttgatat aacgagtaca gtggctttgc tgaatatgta 881461 tgggcttatt tcttcgttag atatgtcagt aacagtcatt gtgttttgga ctgtttttca 881521 ctctctcaga aattggcgcg gaatgcggtg ggctgcgatg gttctgttgg tcgcaatgtg 881581 gttattcttc gatgaataca tcataagccc tttggttgaa tctcaaaagc atttctggcc 881641 tgtaacagtc tattgcaatt ttgatttcca cttccacaat gtttggagat tggaactaaa 881701 acctatccat ctgtctgtgc tagggtttcc tattgctata gtcatcacat tcttgctgct 881761 catcatggct tcaaaactgc ttgatcgtaa agtagaggtg taaatatgga caatcaattc 881821 caatcctcga aaccgattta tctgcagatc gctgatcaga tcttttatag gctggtcagg 881881 aaggagctgc tcccaggaga caagcttcct tcagtaagag aaatggcgat tcaaactaaa 881941 gtaaatccca atacaattca aagaacttac agtgagatgg aaaggctggg tattgtggag 882001 acaagaagag gtcaagggac gtttattgcg gaaaaagcag aaatcgtaga cgagctgaaa 882061 gacaagctga cacgagaggt gctggaaggc tttgtcaagc aaatgaaaga gctggggcta 882121 acgaaagaag aaatgttaga agggattaaa acattcacag agggaggcta aaatggaaat 882181 caagctagaa catgtatcaa aaaaatacgg ccgccatacg gccgtcaatg atgtgtcaat 882241 caccctatca tccggacgga tttatggcct gattggaccg aacggcagcg gcaagtcaac 882301 gaccctgaaa atgatggctg gccttctgtt tccgacttca ggatttgtaa aagttgatga 882361 agagcaggtt acgagagaaa tggtgcgtca aacggcttat cttactgagc ttgatatgtt 882421 ttatccgcat ttcactgtta aagatatggt gaatttttat cagtcgcagt ttcctgattt 882481 tcatacagaa caggtttata agctattgaa tgagatgcag ctgaatccgg aaaaaaagat 882541 caaaaagcta tcaaaaggaa atcggggcag gctgaaaatc gttcttgctt tagcgagacg 882601 ggcagacgtc atcttgcttg atgaaccttt ttccgggctt gatccgatgg tcagggattc 882661 catcgtaaac agccttgtgt cgtacattga ttttgagcag cagattgtcg tgatcgcgac 882721 acatgaaatt gatgaaattg agactttgtt agatgaagta atcatcctcg ccaatggaga 882781 aaaagttgcg cagcgtgaag tagaagatat tcgtgaacag gaaggcatgt ctgttttgca 882841 atggtttaaa tcaaaaatgg aagtttgcta gaaagaggag gaatatgatg aaaacagtgt 882901 tggaattgaa aaacgtgact aaaaacatca gaggccgaac gatcattgat gatctcagtt 882961 ttacgattcg tgaaggcgag gtattcggtt ttttaggacc aaacggagcg gggaaaacga 883021 caaccatccg gatgatggtg gggttaatga agctgtcgaa aggtgatgtc ctcatttgcg 883081 gccaatcaat tacgaaagaa tatgccaagg cgattaagca tatcggagcg atcgttgaga 883141 atcccgagct gtataaattt ttgagcggat ataaaaatct ccagcaattc gcaaggatgg 883201 tcaagggtgt cacgaaggaa aaaattgatg aagttgttga actggtcggt ttaacagaca 883261 gaatccacga caaggtgaaa acatattctc tggggatgag acagcgtctt ggcttggcac 883321 aatgccttct gcacgatccg aaagtgctga ttttggatga accgacaaac ggccttgatc 883381 cggcggggat cagagaaatc agagatcatt taaagaagct gacccgagaa agaggaatgg 883441 ctgtcatcgt ttcaagccac ctgctgtcag aaatggaact gatgtgtgat cgaattgcga 883501 ttctgcaaaa aggaaagctg atcgatattc aaaatgtaaa agatgaaaac attgatgaga 883561 atgatacata tttcttccag gttgagcagc cgagtgaagc cgctactgtt ttaaatcagt 883621 acgatttgct gagtaagaca aatggtgtag aaatcaaact ggctaaagag gaagtccctg 883681 cggttattga attgctggtg atgcagcaaa tccgtattta tgaggtcaag gtcataacaa 883741 aatcattaga ggaccgtttc ttagaaatga caggtgaaac aaaagaggag gttcagcatg 883801 cttaatttga tttataatga gtggctcaaa attttcagcc gtgccggaac atgggtgatg 883861 atcggaattc tggggctgac aatggttgga tttgcatttt tggcgaatca tttttctgcc 883921 ggtgaatcaa attcccattg gaaacaagag cttcaagcac aaaacgccga attaaagaaa 883981 gaaatcaaag aagatccttc actgaaagat gggtataaag aaacaatcac actcaatgac 884041 tatcgcatcg agcataatat ccctagtgac acgggctata cggtatggtc ttatgtaacg 884101 gattcagcaa actttaccat ccttaccggt ctgtttacta ttatcatcgc ggccggaatt 884161 gtcgcgaacg aatttaattg gggaacgatt aagctattaa tgattcggcc gctcagtcgt 884221 tttcaaattt tgatgtccaa atatattaca gttctcctgt ttgggctcct gttgctgttg 884281 attttattta tcggttctac tttattaggg ttgatcttct tcggaacggg tggtgaaacc 884341 gccgcgaata ttcatttaat ctataaggat ggccatgtca ttgagcaaaa catgatgggg 884401 catttggcta caacgtatct ttctgaatcc gtctcggctt taatggtggc gacgatggcg 884461 tttatgctgt ctgcggtatt cagaaacagc tctcttgcgg ttggtttttc catcttcttg 884521 ttggttgccg gtacgactgc aactgcattt attgcagcga aatttgactg ggcaaagtat 884581 atattgtttg ctaatgtcga cttgactcag tatgtggatg gcacaccgtt aataaaaggg 884641 atgactatga cgttttctct cgtcatgctg gcgatctact ttatcatctt cctgttgctt 884701 gctttcggaa tcttcatgaa gcgggatatt gcaaactaat aaaaaaagct gttttgctta 884761 tgcaaaacag cttttttgtc aaaataaaaa ctgcaggttt gcacctgcag tttttcatat 884821 caatttatgc ttacgcttct ttagtaacgt tagcagcttg tggtccgcgg tttccttcaa 884881 cgatttcaaa agaaacagct tggccttctt ctaaagtttt gaagccttcg ccttgaatag 884941 cagagaaatg aacgaataca tcgtcttgac cttctacttc gatgaatccg aaaccttttt 885001 cagagttgaa ccattttact ttaccttcta acatgaaatt tcctcctaaa gcgatcataa 885061 cgcttaaatt cactattctt gctcttaaca aactttcaag acgaaaactc ttacaaaact 885121 ttcttcttaa agatagttcg aacaaaaata attaccttta ctctaccagt aatcttcaga 885181 aaaaacaact gcttattgaa atttttttcg gaaaatacca tatttatttt tcaatttgat 885241 atttatttac ggaaattcat ctgttttctc gatatgtgat catacgtttg ccttagtatt 885301 ccttcatttt gggaagataa gtaataggaa ttgacaacct tattggatat gagtaaggta 885361 aaagttaatc aatattacaa atgacaacgt ttatcaacta agagagcgta tgatttttat 885421 gtctgatatt gcttgcatgc tctaatacat agataggagt atggtcacaa tgaaaaagtg 885481 gcttatatgc agtttcgtcc ttgttcttct cgtttcattt actgcatgtt caccgtctgc 885541 agaacatgaa tcgataaaaa tcgggattgc tgagtctgac ggggcaatat ggaactatat 885601 tgctcaaaag gctgaagagg cagggctgga tattcagctg atcccttttt ctgattatgc 885661 ggagtctgat atcgcacttg ctaacaaaga aattgatgcc aacgcctttc aaaccatttc 885721 atattttcag tcgttcactg aaaaatacaa acttaatttg gcaccgctcg ggacgacata 885781 cataacgccc atgggcattt attcaaaacg atatgaacga atccgagata tatcgcgggg 885841 agctgtcgtt tctgttccgg ataaagcgtt cgattttggc agggcgctta cggtgctcca 885901 ggaagcgggt ttgctaacgc tgaaaaacgg atttaacgga acaggttcag ttgatatgat 885961 taaagataat ccgagacacc tgaaattaaa agctgtccgg caacaggatg cagtgagcgg 886021 tgccgacgtg tttgtcatga aaccatcaga agcaaaaaaa gcgggcttga acccgaaaaa 886081 gcatacgcta aagagcggcg gactcatgtc tgaggaagag atgaatttga ttgttgtcag 886141 agcggaggat caagatcggg aagcgctgca aaccattctt gagctttatc aagctgatga 886201 tacagcggca tttatagaaa aagaatatca gggagatctt gtcccggctt ttctgccttt 886261 gaaacgtctt tcagattgga agaatgaatt cgaacattga attcattctt ttttttctga 886321 aaaacacact ctgttccgtc ccgtttcttt cgctttgtaa agcatttgat cggcaagaat 886381 gggcaaggat cctggctgtt ccgtattatt ggggtaatga gcggccccta gtgatatcgt 886441 aactgaaagc tcgtcgccgt ttgttaatac aatcggtgca tcacttacag tgctcctgat 886501 ccgttcagcg atccgggctg ctttatcaag agaacagttc ggcaggagca cggcaaattc 886561 ttcaccgccg atccgagcgg caggatcagt atttcggatg gtctgcttca gacgtaaccc 886621 tagctctttg agcacctgat ctccttcatg atggccatat tggtcattga tggtcttaaa 886681 atgatcgata tccatataaa tcagtgcaaa ttgaaaatgc ggggtatcgg ccgcctgctg 886741 atacagagct tttgtggttt cttcaaattt tcttcggtta tacacgcctg ttaaaaagtc 886801 aaagtgcgcc tgaaacttat attgtttaaa aagaagatgt gcatttgttt catgatcaat 886861 aatatataaa ctgagcatgc cgcccgctat tgatatgatc caaaaataca aatgaagttc 886921 gtatgaatgt aaatctataa gaaaataaaa ggaaaaggag atcaagctat ttgtgattat 886981 taaaagatag aaagcatgtt ttagttgaac tttttttctt ctagaaacaa tgagtgacgg 887041 aatggcagcg atacaaatga taataaccga gtatagtgca gatgtgttca tcgtaatcag 887101 caagcggcct gcagtgatca tggccagggc cgttgccgtt gaaacccagc ctccataaag 887161 agcggcaatc ataataggga tatttcgaag atcaataatt gaatgctgat aggtaaatcc 887221 aaaaaccatc agaataaccc cgagcaaacc gcaggccagt cctttaacag cttgaaagga 887281 tatgctgtct tttttatgta ctagcctttc tttaaacagg tgggtgaaga gataattaaa 887341 tgtgattaaa atggtcaaat ttacaaacag ttctttcagc aaatattatc acccttatat 887401 aaggtactaa agatggaagg gaaagaaaag aacaaaaaag gcattatata aggttttttt 887461 acttgaattg ataagttaaa ataattcgca cttgacccat cggaattagt gtaatatagt 887521 aaatgagaaa atttgaaggg agagtttacc tgctttggag actttactgg ttgtattaca 887581 tgtatttatt ttatttttac ttatcttagg gctctttgtt atgcagaaaa aacatgtttc 887641 cttctctaaa cgtgtattta ctgcgctggg gctggggatt gtattcggat ttgcgcttca 887701 gctgatttac ggcccgactt caaatatagt cattcaaaca gccgactggt ttaatattgc 887761 cgggggcgga tatgtcaaat tgcttcagat ggttgtcatg ccgctcgtct ttatttcgat 887821 tctcggcgcc tttacaaagc tgaagctgac aaaaaatctt gggaaaatca gcggtttgat 887881 tatcgggatt ttagtagcaa caacagcagt tgctgcagct gtcggtatcg cgtccgcgct 887941 ttcatttgat ctgcaggcga ttcaggttga ccaaggaagt acagagcttt cacggggaca 888001 ggagcttcag cagaaatcag aggatatgac agcgaaaacg ctgccgcagc agattgttga 888061 actgctgcct ggaaacccgt ttttagattt tacgggagct agaccgactt caacgatcgc 888121 tgtcgttatt tttgccgctt tccttggagt ggcattcctc ggcgtaaaac acaaacagcc 888181 ggaacaggca gaaacattta aaaaactggt tgatgccgtt tatgccattg tcatgcgtgt 888241 tgtcacactc attttgagac tgacgcctta tggggtgctg gccatcatga caaaaacaat 888301 tgcaacgagt gatcttgaca gcattctaaa actgggcatg ttcgtgattg catcatatgc 888361 cgcgttaatc actatgttta tcattcattt gctgctgctg acgttcagcg gcttgaatcc 888421 ggtgatttat ttgaaaaaag cggtgcctgt acttgtattt gcatttacgt caaggtctag 888481 cgcaggtgct ttaccgctga atattaaaac acagagaagc atgggtgtac cggagggaat 888541 cgcaaacttt gccggttcgt tcggtctttc gatcggccaa aatggatgtg ccggcattta 888601 tcctgcgatg ctggcgatga tgattgctcc gactgtcggc caaaatccat ttgacccggt 888661 gtttattatc actgttatcg cagtcgttgc catcagctcc ttcggggttg ccggagtcgg 888721 cggcggagcg acattcgcgg cgcttcttgt tttatcatca ttaaacatgc ctgtcgcgct 888781 cgccggtttg ttaatctcaa ttgaaccgtt aatcgacatg gggcgtactg ctttgaatgt 888841 cagcggaagc atgacatccg gtcttattac aagtaaggtc acaaaagaaa ttgatcaagg 888901 ggcatttcat gatcaatcca gagtgattga agctgaagaa gcgtaacata tgaaaacgtg 888961 taatccaaga ggattacacg tttttttaac ggccaggctc taagtcctcc agcatttcca 889021 tcatcgtgtt gtcgtccatg acattcattg cgttttgttc aaaatgaatg ggttcagcat 889081 aatgcggctg tctttttttc gcggctgtct cagtttgcct agtttgagac tgtgtatgct 889141 gatgctgtgg ttgctgctgt ccagcgtgct ggtgctgacg gccattttgc cgctggcttt 889201 gatgctgcga acggtcctgg ttatcaccgc tgcttccgct gcttccgcta aatgcttgtt 889261 tgaccatgtt tcctacatta gaagcatcaa acgtgttatt ttctgaattt cgtctgttca 889321 tttgtcctgt gataaacccg ctgattcttt ggcggatctg aggtgataat gcagtaataa 889381 gcatagttga tcctatgatc aatgctgcgg ggctgattcc tcttcgctgg ttgaacaaca 889441 tgatccctcc tttgcagtgt attcatattt tccccctcgt tagacaaatt aaccgttata 889501 tttcccggga aagcatttcc tccagatttg catgcataat taaagccagt tagaaaaacc 889561 tataagtaaa gtgataaagg aggaattcac atgtttggaa aaaaacaagt ccttgcgtct 889621 gtgcttctta tccctttgct tatgactggc tgcggtgtag ccgaccaagg tgagggcaga 889681 cgtgataata atgatgtaag aaacgtaaat tatcgaaatc cggccaatga cgatatgcgg 889741 aatgtaaaca atcgggataa cgttgacaac aatgttaatg ataatgtcaa taacaatcgt 889801 gtaaatgacg ataataacaa cgaccgaaaa cttgaggttg ctgatgaagc agctgataaa 889861 gtaacagacc taaaagaagt aaagcatgcc gatatcattg tggctggaaa tcaagcctac 889921 gttgcagtcg ttttaaccaa tggaaataaa ggtgcagtag aaaacaatct gaagaaaaaa 889981 atagccaaaa aggtaagatc tactgacaaa aacattgata atgtttacgt ttcagctaac 890041 cctgattttg tagagcgtat gcaaggatat ggaaagcgta ttcaaaatgg tgacccaatc 890101 gccggattat ttgatgaatt tacacaaact gtacagcgtg tattccctaa cgctgaataa 890161 atgaaagaag ccgcacaatt tgtgcggctt tttctttgcg ttaatgacac actgcgaact 890221 caggctgcat agagtaaaaa taaaaaggta caagacggac cggctcaggg agggagacgt 890281 ttgcgggatg gcataggaaa gcgtgcggca tccgctctat tcctgtgcgg agtccttgtg 890341 atgctggctg taagctcagc catcgtatca agcgcgatgt atatcctgtc ttttccaggt 890401 caggcatctg gaataacaaa agaacaagtg acgaagcaca tgaagaaaga gtcattcaaa 890461 caggccgata tttattacac ttctaaggaa aagtccttac tgccattgac gaaagaaacg 890521 cttgaatatg cggtcagtat taatcagatt atgattggat attcgaatca aaagcctatt 890581 gacattattt tttttcctaa tgaaaaacag atggaggctt actccggttt attggatgta 890641 gttggttttt attctgaacg ggagcagctg atcggattgt tgcctgaaga gaaaaagaaa 890701 ctgttagaag gggacgaggt agcggtttat ttgtaccaga gattgttgat tcatgaatac 890761 tcgcaccatg cgtttcacca gaaattgaag gagcttgaga cggatcccga tgagtttccg 890821 ttatggtttc atgaagggtt aagcgagtgg attgcgaact atgaattgct catagatccg 890881 atcacgtttt ctgtcgtgcc ctttgaccgt ttgcagactg atcgagactg gcaggaagct 890941 agagccgaat atgacactga tgtctatttg caaagctttt atatgatcga tgagctgacg 891001 gacaaatacg ggaaagacat tatttcagaa atgattaagg aaacggcaaa aaaaggggac 891061 tttgaaaaag ggtttaaatc agcaacaaag gaaagtcttg atcaatttga aaaagatttt 891121 aagaaaaaat ttgaaaaaaa cagtgcggca ttggatagta tctatccaat gcctttgtta 891181 ttagtgaagt ccttgctgac ccattccgcc ttgtgtcgga ggcatttgtc cttgggcagg 891241 ggcgaatgaa tttcgcagct gttccatatc ctgcgcatca agctgaggaa cctggtaata 891301 gccgtgtttg ttttggtata ggaaaatttc aaatgccatt tcaacatact cctgaatttg 891361 cgcagacagt acgcgtctta cggccggatt tgtcatttcc agagaagcca tcgtcagcat 891421 agaagcttgt gctttaatcg cgcaaagcat ttgtcggctg atgatgctgt catcaatatc 891481 attcatggat tgaacaggtt ttttaggctg tgacggctgc atgccgtaaa cagtctggtt 891541 gtcttccttc atcatataag ttgctgtttt ttgtgaaggt tcgcttcctg ttttgaagca 891601 ttctgcagtt atattgtatt gagatgtgat gaattgatgt tgacgatcaa ggatgtttag 891661 taattcttga tccttacaga attgtctcag catcataaac tgatcaagca cagtaagtgt 891721 tccggaaagc acctcatgca tatcaaacat ttcatgtccg ccgtggtttt tatgcggttt 891781 gccaggaata cctttgttca tttgggattg ctgctgctga ttgaactgat ccaaaccgaa 891841 ttcctccttt tttttcagat cagctgtatt ttgtgtcagt ctgccgtgta ttatgcagaa 891901 gcctgaaagg aattatatgc tgtctgtcga aatgataagc agacaaaatc gttgtcatta 891961 tgtgtataag ggaggaaata tgatgaggcg tattctgcat attgtgttga tcacggcatt 892021 aatgttctta aatgtaatgt acacgttcga agctgtaaag gcagctgaac cgcaacagcc 892081 tatatcgatt gagaaggcaa tacagcaaaa agaaggacag gcacttgtcg aaggatatgc 892141 agtcggccag gctgtttccc cgcagcatta taaactgaca agcccttttt caaatgatta 892201 taatgttgcg ctggcagacc gtaaaaacaa aacatcgccc gaacacatcc ttcctgtgca 892261 aatcccctcc gccttcagaa gccaatttgg gctgcaaacc aatccgcttc ttcttgggaa 892321 aaagataacg gttcaaggaa agcttgaaaa ttactttaac acgacaggac ttaaaaacgt 892381 tcagtcgatg aacgtaaccg atgacacaaa aactccgccg gctgaacagc aagtgaccat 892441 aaatgaagca cggggaaggc tgaatgaaga agtaacgata aaagggatca ttacagctga 892501 tcaaaacgca atcggaggcg ggaagctgtc gacctttttg caagatgaaa ccggaggcat 892561 taacatttat tcgccatccc ctgaacaatt tcccgaatta aaagagggta tggatgtcac 892621 ggtgacaggg aaaatcacgt cttaccaggg gctgaaagaa atcgttccaa actcatcagg 892681 catcaaaatc aaccagtcaa atcaatccct ccccgccccc aaacacttaa caatcaatga 892741 acttattaac ggcagcctag gtgatcagta tgaaggacgc cttgtgaaac taaccgcttt 892801 tgtttcctca attccaagtt ctcctgccgg cggcggttac aatgtaacaa tgattgatga 892861 cgaccatcat gcaatgacgc tccgggttat gaatgaaaca ggggtgataa acgagcttga 892921 tgagggcaaa tggtatgaat ttaccggtgt gttaagcaga taccaaacct ttcagctgct 892981 tccgcgaaaa tcggctgacc tgaagctgct tgaagagcag cccgcacctc cgtctgcaga 893041 gggagaatat gaagggattg ttgaccgggt agttgacggc gataccattc atcttaaatc 893101 tccggtgctt ggaacgacaa aaatccggtt tgtaaatgta gatgcacccg aaacatatca 893161 cacaccaaaa aatgacgcag atgaaaatca attaagattt ggcaaaaaag catctgacta 893221 tctaaaaacg gttctgtccc cgggtgataa aattactgtc aaggtcggga gtgaagccaa 893281 ggacagctat ggcagattgc tcggacaagt cataaccgaa tcaggttcaa acgtgaactt 893341 agagcttgta aaaaacggct atgctccgac gtattttatt tggccggttg acaatgaaga 893401 ggattatcag caatttcagg ccgcagtagc cgctgcaaaa aaagatcaaa aaggaatttg 893461 gaatgaaaac gatcccctca tggaaatgcc gtttgaattc agagccagag agcaagggaa 893521 aggcctgaca agatatgtgg gggactcgtc gaataaaaca tatgtgcagc cagctgactg 893581 gaagaagata gctgtggaaa acagaatttt cttcgcctca gcaagtgaag cggagagcgc 893641 gggatataaa aaaaggcaaa cggcacctca agaacatgtg ccgcttagaa ttctcagcat 893701 gaatgatttg catggcaaaa tcgatcagca atatgagctt gatcttgatg gaaatggaac 893761 tgtagacggc acgtttggac gcatggatta tgccgccgca tatttaaaag aaaaaaaggc 893821 tgaaaagaaa aactcgctga ttgtgcacgc gggagatatg atcggcggaa gctctccagt 893881 ttcctctctt cttcaggatg aaccgactgt agaactgatg gaggacatcg gatttgatgt 893941 cggaaccgtg ggaaaccacg aatttgatga aggcacggat gaacttctga ggatcttaaa 894001 tggcggtgat catccgaaag gcacaagcgg atatgatgga cagaactttc cccttgtatg 894061 tgccaattgt aaaatgaaat caactggaga gccctttttg ccggcttacg acatcattaa 894121 tgtggagggc gtacccgttg cttttatcgg agttgtcaca cagtcggcag ctggcatggt 894181 tatgcctgaa ggaataaaaa atatcgagtt tacagatgaa gcaacagcgg tgaataaggc 894241 ggccgaagag ctcaagaaaa aaggcgtgaa ggccatcgcg gttctcgcac atatgtcagc 894301 tgaacaaaac ggcaacgcca ttaccggtga gtctgctgat cttgcaaaca aaacagattc 894361 tgaaattgac gtgatttttg ccgcgcataa tcatcaggtt gttaacggtg aagtgaatgg 894421 aaaactgatt gttcaagcgt ttgaatatgg aaaagcgata ggtgtcgttg atgtagagat 894481 cgataaaacg acaaaagaca ttgtcaaaaa gtccgcggaa atcgtatatg ttgatcaaag 894541 taaaatcgaa ccggatgtca gcgcgtcagc cattttaaag aaatacgaaa caattgcgga 894601 accgattatc agcgaggtag tcggcgaagc cgctgttgat atggaagggg ggtattcaaa 894661 tgacggcgat acacctcttg gaaacctgat tgcggatggt atgagagctg ccatgaaaac 894721 ggattttgcc cttatgaatg gcggcggcat acgtgaagcg ctgaagaagg gtccaattac 894781 gtggggagat ctttacaata ttcagccgtt tggaaatgtg ttaacgaagc ttgagattaa 894841 aggaaaagat ttaagagaga ttatcaatgc gcaaatctcg ccggtttttg ggcctgacta 894901 cagcatcagc gggtttacgt atacgtggga taaagaaacc ggaaaagcag ttgatatgaa 894961 aatggcagat ggcaccgaga tccagcccga tgccacatat acattgaccg tcaacaactt 895021 tatggcgacg gcgacaggag ccaaatatca gccaatcgga ctgctgggaa aaaatccggt 895081 gacagggcct gaggatttgg aagcgacagt tgagtacgtg aagagttttg atgagccaat 895141 tgcgtataca aaagagggaa gaattaagct tgctgaagcc agtgatattg aagaccctgt 895201 aacagaagac ccgataacgg aagagcctgg agatgatccg gggacggagg atccgattaa 895261 agaggatcca aggccaggtg aagatttgcc tgatataaaa gaaactccgg gaacagcacc 895321 ggttcatcag cttccgcctt cagccatttc gagattcaat gaaataccaa tcaacaacac 895381 aaaaaccgct gatactgcta atagcatcag cacattgccg ttacaaaccg agactgcgga 895441 aagcgggtct gatcatcagc ttccggatac gtcagcgggc tactataact ttatggtaat 895501 cggtgcggcg gtgacattgt caggaactta tctatatgtc agaagaaaaa ggagcgcctc 895561 cagaacgtga aaaaagttat tccactattc atcattgctg ccggcctagt gatcgcaggc 895621 tatggaggct ttaaattgat cgatacgaat acgaaaacgg aacagacatt aaaagaagca 895681 aagctggcgg ctaaaaagcc gcaggaagct tcggggacga aaaatagcac agatcaagca 895741 aagaacaaag catcatttaa gcctgagacc ggccaagcga gcggcatttt agaaataccg 895801 aaaatcaatg cagagcttcc gatcgtggag ggcaccgatg ctgatgattt agaaaaaggt 895861 gtcgggcatt acaaggacag ctattatcct gatgaaaacg gacaaattgt gctgtcaggg 895921 catcgggata ccgtgtttcg ccggacggga gagctggaaa agggggatca gctccgtctt 895981 ctcctgtcat atggagaatt cacatatgaa attgtaaaaa caaaaattgt cgataaggat 896041 gacacatcta ttatcacgct ccagcatgaa aaggaagagc tgattctgac gacctgctat 896101 ccgttttcat acgtcggaaa tgccccgaag cgctatatta tatatggaaa acgagtgact 896161 taaaaagccg aggcagtgcc tgcggctttt cttcatgaaa aatatgtgcg gcaaaggttt 896221 ttcatatcag cagggaaagg ggcttcagca actatgagct cgtctgttat cgggtgaacc 896281 gcttgtactt tattggcgtg cagtgcctgc ctgtttagca gcttgctccc gcctccgtaa 896341 agcgagtctc ctgtcaacgg atggccgagg ctcgccagat gaacacggat ttggtgtgtt 896401 ctgcctgttt ccagctctaa ttcaacgagc gacagccgtt ctttcgcatt gctggccatt 896461 accttgaaat gagtgacggc tgtttgcccg cctggtgaaa cccggcgtct tgtcgggtgt 896521 gagcggtctc tgccgatcgg tgaattaatt gtcccttttt tcgtccgtag cttaccttca 896581 gcgatagcgg tatacgtacg cttcagcgtc tttttctcta actgctggtc taagatggcg 896641 tgtgccaaac gatgcttggc aaaaacgata gcgccagatg tatcctgatc aagacgatgg 896701 acgtggcgca ccttacatgt ttcgccattt atctgataat gatacgcgat caaattagcc 896761 agtgtgccgg tttgcccatc ctcattcgga tgcgtcgcga tgccagcggg tttattgatg 896821 atgagcatat gattgtcctc aaataaaata tcaagctcgc catactccgg aatgaccgaa 896881 gatgcttcac tttcctgaag atcaatgaac acgcggtctc ccttttttac aatcatattg 896941 tttaagacgg attcgtgatt gacctttatc tgttgatggg acatccagtc ttgtatcact 897001 ggtttagaag ctttgagcgc tgttttgagt acggaaaaca gccattggcc gtcctgtttt 897061 tcattgatga ggatctcaag ccctctgcct ttttggttca tgttaaatgg ctccttttcg 897121 aagcggaagg ctgctgtttc tcataggaaa cacttacctt agctttcgcg tttttttctg 897181 tgctattctt gagtaagact taggatattc gatggcaaga aaggtgattg acgtgagaat 897241 tgtgaacgca gcaactgcag aacaggagag ctttatcaag gagctgtcta tggagctgat 897301 ccatgatgta tttcctcttt atttctccga actggacatt cagcgcttta aaaagaaagg 897361 cgttctgtct ttaaataacc attattacca aggaacatta aaagaagcat ttcaaattat 897421 ggcttgtctg caaatgatac atattatcct gaccaagcct tcgccgcact ctgatttgag 897481 tgatcaggcg atttttgaaa aaaacagcaa gatgctgaat gattttggga tttattttcc 897541 gtttgctttt tctgactttc aaaagaagac taacaaagcc tttttcggtc aaagaaggct 897601 gatataatca tgcggcaagg gcttttctat ttttagaaaa gctctttttg tatcagagaa 897661 atcatatcat aaaacctttc ctctaactcc ctttttaaac ggctcgtgtc tgaacatact 897721 aatgattgaa aggggtgctg acaatgagtt cagttaaaga tacaatgaca acgcaggtgg 897781 caaccgtttc tccgaatcaa acgattcagg aagcggcttc tctaatgaaa cagcataacg 897841 tcggggcgat ccccgttgta gagcaaggtg ttttaaaagg aatgctgact gaccgtgaca 897901 ttgcattaag aactacagct cagggccgtg atggccagac acccgtttca gaagtgatgt 897961 caacagaact cgtatcagga aaccctaata tgagtctgga agacgcgtcg cagctgatgg 898021 cccagcacca aatccgccgc cttcctattg tagatcaaaa caatctagtc gggatcgttg 898081 cgcttggaga cctggcagtc aatcagatgt cgaacgagtc tgcgggatca gcgctgacaa 898141 acatttctca ccaaaacatt cattaataag aaagagcttg cagtgtgcag gctctttctt 898201 cacataaaac cttacttttt gaaagcagac ttgtttcggg gtatagtgag tgtatacata 898261 tgtctcaatt cgtactaaag gagttgtacc cagtgattaa agcgttaatt tttgattttg 898321 acgggcttat tctagataca gaaacacacg aatatgaggt tcttcaggaa atatttgaag 898381 agcacggctc agtgctgccg ctatctgtct ggggaaaggt catcggaact gctgcgggtt 898441 tccggccttt tgaatattta gaagagcaga tcgggaaaaa gctgaaccat gaagagctca 898501 cacaattgag aagagagcgg tttgccaaac gcatggaatc agaaaaagcg agacctggtg 898561 tcgaagcgta tttgaatgcg gcaaaggatt taggcttaaa aataggcctt gcctccagct 898621 ctgattataa atgggtgtcc ggccatttga agcaaatcgg cctgtttgat gattttgaag 898681 ttattcaaac ggcggatgat gtggaagagg tgaagccgaa tcctgaactc tatttattgg 898741 cggcaaagaa cctgggggta tcgccagcgg aatgtctcgc gtttgaggat tctgtcaatg 898801 gttcgattgc tgcgaaacgt gcaggcatga agtgtgtcat tgtcccgaat aaagtaacgg 898861 gtaccttgat gtttgaagac tatgatcaca ggcttgaatc aatggcggag atggagctcg 898921 ccctattgct tgatcatctg aactcacaaa actagaaagg agcgagtagg ttgtctgaga 898981 aattagattt gacccggttt gaaaagaaaa tggttatccg caatatcgaa gagaaagaca 899041 tcgacaagat tatcgatctt caaaaggact gctttccagg aatggagcct tggaagcggg 899101 agcatttaat cagccatttg gagcattttc cggaaggaca gttttgtgca gaattcgaag 899161 gtgaaattat cggttcgtgc tcaagtctcc tgattaactt tgatgaatat gatgaccgcc 899221 atacgtggca ggacattaca gatgacggtt atatcaccaa ccataatcct gacggcttga 899281 atatgtacgg aattgaagtc atggtgcacc cgaaatacag acgaatgaag atcggccacc 899341 gtttgtacga ggcgagaaag gacttagcca gacgcttaaa cctgaaaagc atcatcatag 899401 gcggacggat tccaaactat cacaaatatg cagaggaaat gacagcgaga gagtatgttg 899461 aacaggtgac acgccaccaa atttacgatc cggttctttc ttttcagctg atgaacggct 899521 ttacccttat gcgaattaac ccgaactatc tcccggatga tacagcttcg atcaagtatg 899581 cgacgctgat ggaatggaat aatgtcgatt atctaccgca gcagacaaaa cgctattata 899641 aatcggcgtt ccctgttaga atttgtgtga tccaatacga aatgaagaaa atttattcct 899701 ttgaggaatt tgcgaatcaa gtagaatact atgtcgatgt tgcttccgac gcaagatctg 899761 attttgcggt gttcccggaa attttcacaa cccagctgat gtccttcctt gaggaacggt 899821 caccgagctt ggcggtgcag agaattaccg agtatacaga agattacatc agcctgttta 899881 ctgacttggc tgtgaagtat aacgtcaaca ttatcggcgg atctcatttc gtcgaagagg 899941 aaggcaagat ctataatatc gcttacctgt tcagacggga cggaacgatc gagaagcaat 900001 acaaactcca tattacgccg aatgaacgca aatggtgggg gatcagcgca ggagaccaag 900061 ttcgcgtgtt tgatacggac tgcgggaaaa tcgcgatcca gatctgttat gacattgaat 900121 ttcctgagct tgcccggatt gcggctgata aaggagccaa aatcatcttt acgccatttt 900181 gtacagaaga ccgtcaaggc tatctgcgtg tcagatactg ttcgcaggct agagcggttg 900241 aaaatcaaat ttatacggtt atctctggaa cggtcggaaa ccttccgcaa acggaaaaca 900301 tggatatcca atacgcccag tcaggcatct ttgccccgtc tgattttgaa ttcgcccgag 900361 acggcattgt cggcgaaaca aacccgaata ttgaaatggt cgtcatcggc gatgttgacc 900421 tggaaattct cagaagacag cgccaaaacg gtacagtgcg ccagctaaaa gacagacgac 900481 gtgatattta tcatattcaa tataaaaaat aattcccaaa aaacccgcct gaattggcgg 900541 gtttttttaa acaaaagcgg aattgtttag gtgctttctt taaaataaaa gtaaattgta 900601 tagtggatgt gccttatgga gtttctgtat tttcgccatt tcctatatca tacagaaaac 900661 ggctaggctt cacattgcta ttgcaatggc tgtccaagtt gtttcgagtg cgacctttat 900721 cagtacgatg ctgagcattg tcactttgcc tgttttgctt tggaagctgc atcctctttc 900781 ttcttgagaa aggggatgtt ttattattta cgcggtttat tgactctgac ccggtctggc 900841 tttatattga aggcagggaa atcatcacca agacatcaca taaagagaag gtctgtttca 900901 attgaattgg cattataggg aacgctaatg aaatggagat gatggggatg gaaaacattc 900961 agcaaaatca gggattaaag caaaaagatg agcaatttgt gtggcatgcc atgaagggag 901021 cgcatcaagc ggacagcctg atagcccaga aggccgaagg ggcctgggta accgacacag 901081 acggacgccg ctatttggat gcgatgtccg gtttgtggtg cgtcaacatt ggttacggca 901141 gaaaggagct tgcggaggct gcctatgagc aactaaagga gctgccttac tacccgttaa 901201 cgcaaagtca cgcacccgca attcaactgg cggaaaagct gaatgaatgg cttggcggcg 901261 attatgttat ttttttttcc aacagcggat cggaagcaaa cgaaactgct tttaaaattg 901321 cccgccagta ccatctgcaa aacggcgacc acagccgtta taaattcatc tcaagatatc 901381 gggcatacca cggcaataca ttgggagcgc tctcagctac cggacaggcg cagcggaaat 901441 ataaatacga gcctttgagc caagggttcc tgcatgcagc tccgccagat atataccgga 901501 atcctgatga tgcagacacg cttgaaagcg caaatgaaat cgaccgcatc atgacatggg 901561 aattaagcga aacgattgcc ggggtcatta tggagcccat cattacaggc ggaggcatcc 901621 taatgccgcc ggacggatat atgaagaagg tggaggacat ttgccggcgc cacggagccc 901681 ttttgatttg cgatgaagtg atctgcgggt ttggacggac aggtgagccg ttcgggttta 901741 tgcactacgg tgtgaagcct gatatcatta cgatggcaaa gggaatcaca agcgcgtatc 901801 tgccattgtc agcgactgct gtgaaacggg acattttcga agcgtatcag ggggaagctc 901861 cttatgaccg tttccgccac gtgaacacgt tcggcggaag cccggctgcc tgtgctttgg 901921 cgttgaaaaa cctgcaaatt atggaggacg aacagctgat tcagcgatcc cgtgatcttg 901981 gagcaaagct tttaggtgag cttcaagctc tgagagaaca cccggcagtc ggggatgtta 902041 gaggaaaagg gctgctgatc ggaatcgaac tcgtcaaaga caaattgact aaagagccgg 902101 ctgatgccgc caaagtaaac caagtggttg cggcgtgcaa agaaaaaggg ctgatcatcg 902161 gcaaaaacgg cgatacagtc gccggctaca acaatgtcat ccagcttgcg ccgccatttt 902221 gcctgacaga agaggacctt tcctttatcg tgaaaacggt gaaagaaagc tttcaaacga 902281 tataatataa aagtgaatta ttaaaggagc acatgatgag ttttcacaac cagccgatct 902341 taccggctat tcgcaatatg aagcaatttg atgagttttt gaacagttca ttctcttacg 902401 gtgttattct tgatattcat ctcggccagc tgaagggcgt gatcaaagaa gcgcaaaagc 902461 acggaaagaa catgatggtg cacgtcgatc tcattcaagg gattaagcat gacgaatacg 902521 gtgcggaatt tatatgtcag gatatcaagc ccgctgggat tatttccaca agatcgaatg 902581 tgattgccaa agcgaagcag aagaaaattt atgccattca gcgcctgttt ttgcttgata 902641 caagcgcgat ggagaaaagc atggagttta tcggcaagca taagcctgac ttcatcgaag 902701 tgcttcccgg catcgttccg tcactcattc aggaaataaa agagaaaaca gggattccca 902761 tctttgccgg gggtttcatc cgtacggaag aggatgtaga gcaggcattg aaagcggggg 902821 ctgtagctgt cacaacatct aataccaaat tgtggaaaaa atatgaaaac tttttgacgg 902881 aaagtgattg acaccgcttt catgcactga tacaattgca ctaggttaat acattgtgat 902941 ggagaactcg gagaccacag cagctcttta cggcaaatgt ttatgcaccc gtaaagcggt 903001 ttgttgtggt ttttttattc tcttcttctc tatcatgctt tttaatcgtg actttaggag 903061 gaatgtgcta tgacagcatt ttggggagaa gtcatcggta cgatgctgct tatcattttt 903121 ggtgcaggtg tttgtgcagg tgtcaattta aagaaatcgc tttcattcca gtctggctgg 903181 attgttgttg tatttggatg gggattgggt gttgccatgg cggcatacgc ggttggcggc 903241 atcagcggtg cccatttgaa tccggcgcta acgatagcgc ttgcatttgt aggagatttt 903301 ccttggaaag aggttccggt ttatattgcg gcgcaaatga tcggagcgat catcggtgcg 903361 gtgattattt atctgcatta cctcccgcac tggaagtcaa cggatgatcc cgctgccaag 903421 ctgggtgttt tctcaacagg gcccagcatt ccgcatacat ttgcaaacgt tttaagcgaa 903481 gtgattggga catttgtcct tgtacttgga atcttggcca taggtgcaaa tcaatttaca 903541 gaaggactta atcctttaat cgtcggtttc ctcattgtag caatcggtat ttctctggga 903601 ggcaccaccg gctatgctat caatcctgca cgtgacttag gtccgcggat cgcccacgct 903661 tttcttccga ttccggggaa gggctcatca aactggaaat acgcatgggt tccggtagtc 903721 ggcccgattt taggcggatc attcggcggt gtattttaca acgctgcatt taaagggcac 903781 atcacaagca gcttctggat tgtaagcgtt atattggttg tggtattgtt aggactctat 903841 gtttatacga aatcacattc tgctaaaaca ttatcaaatt ctaaatatat ttaatcaaag 903901 gggagacatc ttatggaaac gtacatttta tccttagatc aggggacgac aagttcaaga 903961 gcgattctgt ttaataaaga aggcaaaatt gtccactctg ctcaaaagga atttacacaa 904021 tacttcccgc atcctggctg ggttgagcat aatgccaatg aaatttgggg ctctgtcctc 904081 gcggttatcg cctcagtcat ctctgaatca ggaatcagcg cttctcaaat tgccggcatc 904141 ggcatcacga accagcgcga gacgacggtt gtgtgggata aagatacagg aagtcctgtc 904201 tataatgcaa tcgtttggca gtccagacag acgtccggca tttgtgagga acttcgtgaa 904261 aaaggatata atgataaatt cagagaaaaa acagggcttt taatcgatcc ttacttctcc 904321 ggcacgaagg tgaagtggat tttagacaat gtggaaggcg caagagaaaa agcggaaaaa 904381 ggcgagctgc tgtttggaac gattgatacg tggctcattt ggaaaatgtc aggcggaaaa 904441 gcgcatgtga ccgattactc caatgcctca agaacactga tgtttaatat ttacgattta 904501 aaatgggacg atgaactgct cgacattcta ggcgtaccga aatccatgct ccctgaagtg 904561 aagccgtcct ctcatgtgta tgcggagact gttgattatc acttcttcgg aaaaaatatc 904621 ccgattgctg gagcggcagg cgaccagcag tccgcattgt tcggccaggc atgctttgaa 904681 gaaggcatgg ggaaaaacac ttacggcaca ggatgtttca tgctgatgaa taccggggaa 904741 aaagcaatta agtccgaaca tgggcttttg acaacaatcg cttggggcat tgacggaaaa 904801 gtgaactatg cgttagaagg gagcattttt gtcgcaggct ctgccatcca gtggcttaga 904861 gacggtttga gaatgttcca ggattcatcg ctaagcgaat cttatgcaga aaaagtggat 904921 tcaactgacg gcgtgtatgt tgttccagca tttgtcggac tgggaacgcc ttactgggac 904981 agcgatgtgc gcggttcggt tttcggcctg acaagaggga caacaaaaga gcactttatc 905041 cgtgcgacac tggagtcatt ggcttatcag accaaagatg tgcttgacgc aatggaagca 905101 gattcaaaca tttcattaaa gacgctccgt gtagacggag gagctgtaaa aaacaatttc 905161 ctaatgcagt tccaaggaga cctgttgaat gttcctgtgg agcgcccgga aattaatgaa 905221 acgactgcac ttggcgcggc ttatttggcg ggtatcgctg tgggattctg gaaggaccgt 905281 tctgaaatcg cgaaccagtg gaatctggat aaacggtttg agcctgaatt ggaagaagaa 905341 aaacgaaatg agctgtataa aggctggcaa aaagccgtga aagcagctat ggcttttaaa 905401 taaagtaata ctatggtata atggttacaa gttaataaga acggtcctga gatgaggaga 905461 gaccacagca ccaaagtgta agcatgcact ttggctgttg tggtctcttt ttctatttac 905521 cgtgacaaca aggaggaaac gtaatgatga atcatcaatt ttcaagtctt gaaagagatc 905581 gcatgctgac agacatgacg aaaaaaacat atgacctatt tattatcgga ggaggaatta 905641 caggagccgg aacagctctt gacgcggcat caaggggaat gaaggtcgca ctaagcgaaa 905701 tgcaggactt tgcggcggga acatcaagcc gatcaacgaa gctggtacat ggcggcttgc 905761 gctatttaaa acaatttgaa gtgaaaatgg tcgctgaggt aggaaaagag cgggcgattg 905821 tgtatgaaaa cggcccgcat gtcactacac cggaatggat gctgcttccg tttcataaag 905881 gcggcacatt cggttcattt acaacatcta ttgggttaag ggtttatgac ttccttgcag 905941 gtgtgaaaaa gtcagaacga agaagcatgc tttcagcaaa agaaacgctg caaaaagagc 906001 ctttggtgaa aaaagacggc ttaaaaggcg gcgggtacta tgtggaatac cgcactgacg 906061 atgcgagact gaccatcgaa gtcatgaagg aagcggttaa attcggggca gagcctgtga 906121 attactccaa agtgaaggag cttctttacg aaaaaggcaa agccgtcggc gtattaattg 906181 aagatgtgct gacaaagaaa gaatataaag tgtatgcgaa aaaaattgtc aatgctacag 906241 gcccttgggt cgatcagctc agagaaaaag accattcgaa aaacggaaag catttgcagc 906301 atacaaaagg cattcacctt gtatttgacc agtctgtctt tccgctgaaa caggctgtat 906361 atttcgatac acctgatggc cggatggtat ttgcgattcc tcgtgaaggc aaaacatacg 906421 tgggaacaac agacactgtt tacaaagagg cgctggagca tccgcggatg acaacggagg 906481 atcgtgatta tgtcatcaaa tcaatcaatt acatgttccc ggaactgaat atcactgcga 906541 atgacatcga atccagctgg gcggggctgc gtccgctgat tcatgaagaa ggcaaagatc 906601 cttctgaaat ttcacggaaa gacgagattt ggacatctga ctcaggcctg atcaccattg 906661 ccggcggaaa actgactgga tacagaaaaa tggcggagca catcgttgat cttgtccgtg 906721 atcgcttaaa agaagagggc gaaaaggatt ttggaccatg taaaacgaaa aacatgccaa 906781 tctctggcgg gcacgtcggc ggttcgaaaa atcttatgtc cttcgttacc gcgaaaacaa 906841 aagaaggaat tgcagccggt ttatcagaaa aagacgcaaa acagcttgcg atcagatacg 906901 gctctaacgt agatcgcgtc tttgaccggg tagaagcgct gaaagatgag gccgcgaaac 906961 gcaacattcc ggttcatatt cttgctgagg cagaatacag tatagaagaa gagatgactg 907021 caacccctgc tgacttcttt gtccgcagaa cgggacgttt attttttgat atcaattggg 907081 taagaacata taaagatgcc gttattgatt ttatgagcga gcgattccaa tgggatgagc 907141 aggcgaaaaa caaacataca gaaaacctca acaagctttt acacgatgcg gtcgtaccgc 907201 ttgagcaata aatcataacg ggctgtctgc agcccgttat ttctttttac gtgccgaaag 907261 ggggagatct caggttatca agtgacagag gcacccgctt catataaaat aatggcataa 907321 gctgatacat aggaggacga atatgacttg gagaaagagc tatgaacgct ggaaacagac 907381 agaacattta gatctggaat taaaagagcg ccttattgaa ttagagggag atgaacaggc 907441 ccttgaggac tgtttctata aagaccttga attcggtacc ggcggaatgc gcggggaaat 907501 cggcgccggg acaaatcgga tgaatattta cactgtgcgc aaagcatcgg ccgggtttgc 907561 ggcatacatc tcgaagcaag gtgaggaagc gaaaaaacgg ggcgttgtca ttgcttatga 907621 ttcccgccat aagtctccgg agttcgcgat ggaagcggca aaaacacttg cgacacaagg 907681 catccaaaca tacgtgtttg atgagcttcg cccgacgcca gagctgtcat tcgctgttag 907741 acagctgaac gcttatggtg gaattgtggt aacggcaagc cataacccgc ctgaatataa 907801 cggctacaaa gtatacgggg atgatggcgg ccagctgcct ccaaaggaag cggacatcgt 907861 cattgagcag gtaaacgcga ttgaaaatga gctgacgatc acagtggacg aagaaaataa 907921 gttaaaagaa aaaggcttaa tcaaaatcat cggtgaagat attgataaag tttatacaga 907981 aaaactgacg tccatttctg tacatcctga attatcggaa gaagtagatg taaaggttgt 908041 tttcacaccg ctgcatggaa ctgcaaataa accggtcaga cgcggtcttg aagcactcgg 908101 ctacaaaaat gtaacggttg tcaaagaaca ggaactgccg gattcaaact tctccactgt 908161 tacatcgccg aacccggaag agcatgcggc attcgaatat gccattaagc ttggggagga 908221 gcagaatgca gatattctca tcgcgacaga tcctgatgct gaccgcctcg gcatcgcggt 908281 gaaaaacgat caaggcaaat atacagtgct gacaggaaac caaaccggag cgttgctgct 908341 tcattacctg ctttctgaaa agaaaaaaca aggcatcctg cctgataacg gtgttgttct 908401 caaaacgatc gtcacaagcg aaatcggccg tgctgtagct tcttcattcg gccttgatac 908461 gattgatacg ctgacaggct ttaagtttat cggtgaaaag attaaggaat acgaagcatc 908521 aggccagtat accttccaat tcggttatga agagagctac ggttatttaa tcggggattt 908581 tgcccgcgat aaggacgcca ttcaggctgc gcttttggca gttgaagttt gcgcgttcta 908641 taaaaaacag ggaatgtcat tgtatgaggc gctcatcaat ctctttaacg aatatggttt 908701 ttatcgtgaa gggctgaaat ccctgacgct gaaaggcaaa caaggagcag agcaaattga 908761 agcgattctt gcttccttca gacaaaatcc gccgcagaaa atggcgggca aacaggttgt 908821 cacagcagaa gattacgctg taagcaaacg gacgcttctg actgaaagca aagaagaagc 908881 catcgacttg ccaaaatcaa atgtattgaa atacttcctg gaagacgggt cttggttctg 908941 tctccgtcct tctggaactg agccgaaggt taaattttat ttcgccgtaa aagggtcatc 909001 tttggaagac agtgaaaagc gacttgccgt cctttctgaa gatgtaatga agacggtgga 909061 tgaaattgtt gagtcaacag caaaataatt caagtatgag ctgggtcatt gtaaatgatc 909121 cggctttttc tttttctcat ccaaaagtct gaaagaaaat catcctacaa gtgaagcaat 909181 gaaatacaaa aaactggtat aatcttaaat acaagatcaa tgccggagtg agaaacgtga 909241 gcaaaacgag gatggaaaaa ttaaaaacgc tgaaaacgat tgcggaaacc ttaaatcaag 909301 ggcacgatat caaagcaaca ctggatgagg ttttaaaaga gttgctgagt ctgacaaacc 909361 ttcaatccgg atggattttt ctgatcgaag aagatgggtc ttatacgtta gcggccgacg 909421 cttatctgcc cccggcttta agccgcaagg aaaaagtgct gatgtgcgaa ggggagtgtt 909481 actgcctgac gaaattcaat aacggagggc ttagaaaagc tgcaaatatc atgaactgca 909541 aacgcatcga atcagcagaa aacctgcatt gttttgacac agaagggatt acgcatcatg 909601 caactgtgcc tttagaagac ggggacagaa gattcggatt gttaaatgta gcggcggccg 909661 gaaaaaccat gtttgatgag gaagagctgc atttactcga gtctgtcgcc tttcagatcg 909721 gaacggcaat ccagcgtatg aggctttctg aatatcaaca aaaaaatgct cttttaatgg 909781 agcgtaaccg cctcgctcag gagcttcacg attcagtcaa tcaaatgctg ttttccgtca 909841 gtttaactgc caaagctgcg aagacactaa caaaagatga aaatttacag cagatgattg 909901 atttcatcca aaacctatca caggacgcgc tcgcagaaat gaaagcgtta atttggcagc 909961 ttcgccccgg aggattggaa aaagggctgg ctgaagccat taaaagctat ggtgcgctca 910021 ttggattgaa gatcattttt acacaaaaag gctgtcctgt tctgactgat gagcaggagc 910081 atatgctatg gcgtgtcgta caggaagctt taaataactg caaaaagcat gccggaacgg 910141 atacggcgta tgttagtctg actgcttctt tgtgccatgc ggagctggat atcatcgatc 910201 atggggcagg atttcgctat gaagcgcatg ccggtctgcc ttcacttggc ataaaaggta 910261 tgaaagagcg agcggaaaaa gccggagcta agttttggat tgagtcagcg cttggaactg 910321 gaacaaagct gtccatcagg cttccgctaa aaagccgaaa aggaggggcg gtatgaaaat 910381 tgtcattgct gatgatcatc atgttgtcag aaagggtctg cgttttttct ttgccaccca 910441 ggatgatatt gaagtcgtcg gagaagctgc aactggatta gaagccctcc gtgtcatcga 910501 agagacaaag ccggatcttg tgctaatgga tttgtctatg cccgagatgg acggcattca 910561 agccattaaa aaagcaatac agcaatttcc ggatacgaat atcattgtgc tgacgagcta 910621 ctctgatcag gagcacgtca tccccgcgct tcaggcaggc gcgaaggcgt atcaattaaa 910681 ggatacggag cccgaggaat tggtgaaaac acgacaagtg catggtggcg aatacaagct 910741 ttctacagct attatgcccc atgtgctgac acatatgaaa aatcagcacg acccggaaaa 910801 agaaaaatac tatcaattaa ctagaaggga aaaagacgtt ctgactgaaa tagcgaacgg 910861 gaaaagcaat aaagaaatcg cagcagcctt gtttatttca gaaaaaacag taaaaaccca 910921 tgtatcgaat cttttagcaa aacttgaagt ggccgatcgc acgcaagcag cgcttttcgc 910981 agtgaaatat aacctgaatg gagagatctc aaaatgaaca tgttagtcat aaatggcacg 911041 ccaagaaaac atggcagaac aagaattgca gcatcctata ttgcagctct gtatcacacg 911101 gatttgattg atctaagcga gtttgtattg cccgttttta acggtgaagc ggaacaatct 911161 gaactgttga aagtacagga gcttaagcaa cgcgttacga aagcggatgc gattgtatta 911221 ttatcgcctg aatatcacag cggcatgagc ggcgctttaa aaaatgcctt ggattttcta 911281 agcagcgaac aattcaaata taagcccgtt gcattattgg cagtagcggg aggcggaaaa 911341 ggcggcatca atgcgctgaa caatatgaga actgtgatgc ggggtgtcta cgccaatgtc 911401 attccgaagc agctggtgct tgatccggtg catattgatg ttgaaaatgc tacagtggct 911461 gaaaacatta aggaaagcat aaaagagctt gtcgaagaac tcagcatgtt cgcaaaagca 911521 ggaaatcccg gcgtctaaac gccgggattt gtttatgtga gaagggctat ttgatcttca 911581 taagtcagct ctgtggcatg atcaatatat cggagaaggg aatacagcat cttttctaaa 911641 acggcgtaat cctgttcaaa atgatacgca tgcagaaaat gctcaattcg ttttgataac 911701 aaatcgtcct ctgtacgcac cattaaaatt aataaattat cccattgaga acgatgggtg 911761 taataaagcg ctttatcgta atcggcataa tccatgaatc gcttctcctt tcttgggtga 911821 gaagttcatg attagtttat gccgcatcct ctgttattga cggggcaaaa cttgccgtct 911881 gcgtcagtaa aggggtagca atatgaggga gacataaaat caaaatgcct gaatgaagat 911941 atcgcttttg gtaaacctat gagggaatat attctgggta caggagactg aaaaaatgaa 912001 atccctgccg tataccatcg cacttctttt ttgcggattg attatcgtgt caatggctgc 912061 aaaaggtcat tcaacggaca cagacgagtc cgttcaaaag tgggaacagc ttgcctggag 912121 caaaattcag gatgaatata agggcgcttc attttctgat tatgcttata tggggcgtac 912181 agaggtgaat gatcagcaga ctaaagatgt ctttcgggtg acagtcagac agaaagatga 912241 cactttttct gttcgggccg aagtctattt tcatccggtg acaaatcata tgatcagcat 912301 caacgtcttt aggctctaat aaaaaactgt acagccgtta aggccgcaca gtttctgttt 912361 ttagaaatat cgttttgcac cgagatagcg ctgtttccag taagagttgt tcatattgga 912421 aatgacaact ccggaatcgt tggcatttat gaattccccg ttgcctaggt aaattccgac 912481 gtgggaaggg ccggctttat atgttgaaaa gaaaacgaaa tctccgacag caggctggct 912541 aactgatttc attgtgttcc aatatcccgc tgccgttaat ctagatacgg atgtgacttt 912601 gttcagtaca tagtaaatga atccgctgca gtcaaacccg gacggtgtcg tgcctcccca 912661 gcgatacgga accccaagct gcgctttagc ggccgaaatc attgtgttaa tcttcgcact 912721 cgttgagctg gtggtgtttg aagaaccgga tgaagacgat gatgaagctt ttccggaaat 912781 gaccagcttt tggccaacct gcaagacatc cgtttttaaa ttgtttttct cacgaatctg 912841 ctgagctgtt acattaaatt tttgagcaat cacccataag gaatcaccgc ttttcaccgt 912901 gtatgtagtc gtcgtgccgg agcttgcatt tgacgaagaa gacgacgatg atgaagagcc 912961 tgaagatgct ttacctgtca gcttcaatac ttgtccaacg taaagcacat ctgatttcag 913021 attgttgata tttcggattt gctgtacagt caggttatag ttgtttgcga ttttccaaag 913081 tgaatcaccg cttttaacgg tatatttagt tgttgctgaa gtttggttcg atttggatga 913141 attgtcttta gaagacgtat cagagccgct tgattttgtt ttcaacacct gattcacgta 913201 aatggtgtct gattttaagt tgttcaagac cttcaattca gcgatggaca tattgacttt 913261 gtttgcaatt ttccaaagtg aatctccaag ctgcacctta tatgttcccg tagaagatga 913321 agaacttgaa ctcttattag aactgctttt tgaactggag cttgaactct tattagagtt 913381 gcttttttta ctggaactag agcttgaaga aacagtaccg gacaccttta atttctgccc 913441 agcacgaatt aaatcgctgc ttagtccgtt taattttttc agttcctgca ccgtcatttt 913501 aaactcattt gcgatcagcc aaagtgaatc tccgcttttc actgtgtaaa cagaacttcc 913561 gctcttcttg gttgttgagc ttgaagtaga tgaagaagtg ctggatttgc tgcctggaat 913621 agtaagcgtc tggccgatcg acagaacagt agtcgaaaga tgattggcgg atgtgagggc 913681 cgccacactt gtgttatagg tttgggccag tttccataaa gaatctccgc ttttgacctt 913741 aatcgttgct gcttcagctg gtgtcactac taaagttgtg ccgacaatcg cagatgctgt 913801 cagccctgct gctaatttct ttttcatctt agctctcctt tttcccccaa tgattttgca 913861 tttgctgttt cttttttata tcggcacatt tgtctcatcg ttttgccttt ttataaaaat 913921 agccaaatta tcttaacaat aagggggaaa aagggcataa aaaaagaagg aatcttaatc 913981 tattccttca tttttaaaag cttcatgata tcttctttgt ttttgacgag gtcgcgcagt 914041 gtgtatttgt ctaaaactgc gaggtaggct aaaagcgctt cattcagcac atgttttaag 914101 ccgcaaaccg gggaaataac acagagattc ttgttcgcat caaaacattc aacaatatta 914161 aaatcgtcct ccgtttttct gacaacctca ccgatgttga tgtcttcagg gtccatgcct 914221 aatcgtatgc cgccgccccg tccgcgtatc gtttctacgt agccgagctg gccgagcctg 914281 tatatgactt tcatgagatg attttttgaa atagaatacg tttcggcaat ctgttttata 914341 tttgaaagtt ctccgggacg ctctgcagcc agaaaaatca acactcttaa tgaataatct 914401 gtataattgg ttaacttcat aataagacct cagaataaga cattttctat atcttatcat 914461 aatcgattga aaaatgaaaa aaaaggaatt aaaaaacatg cacccagctg ggtgcatgtt 914521 ttttgcttac atgtcattcg gcggattttg gtttttacgg tttttttcga tttctgtgtt 914581 ttgcattttg cgttcaaatg tagacagata acgtgatgca aaatccttac cgccaaggcc 914641 gaaggataaa ccaaaagcaa gtgcgaagcc gctaagaacg atgatgaacg cggaattgac 914701 gattgtcgca gcgacaccca gctgatccag ggccataaag aaagcaagtg cgataatcgt 914761 atatttagca ataggcgcta aagacttgaa ttcctgacct tttatcatgc ttgcgagcac 914821 ttttctcacc aattctcctg cgtaaaggcc gagtccgaga atgaatactg cgacaaggac 914881 attcggcaga tacgcgatga tgccggtggc aatttctacg aggaagtgca gccgaacaat 914941 ttgaagcgcc tcagctgtaa agagcagaat gacaatgatt tgcgcaatca taccgacaac 915001 ttgagacaag gacagctttg caggcgttcc ggcttccatg cccattttcc ctaagacaga 915061 atcaaagcct gcgcgatgga gcagtccgga caccatggat ttcacccatt ttcctgccca 915121 gatacccgct aatacaagca cgatggcaat catgatgttc ggaagcatgt ttaaaatcgt 915181 attcagcata gagacagctg gttttgaaat gccggcgaca tccagctgat caagcgctga 915241 aatgaccacc ggaatcataa tgagcacata agcgattgtt ccgatgactg ctgaaaggct 915301 tgtgtctttt aagtaaattg ataaacccat acgtgccgcg aatctttcgg tgccgatgct 915361 tgcaaggaaa ttcgtaatga tatcacggac aaggcgggca acaagccatc cgattaatac 915421 gataagcgcc gctgcaaata atttcggcag aaaagcgagc acgctttcca tcatatttgt 915481 aaaaggacct gaaatgccgc tgattttcaa agaagataag acccctggca gaaaaacaag 915541 cagcacgaga taaaagacaa tttgtgaagc ggtattgaca gcctggtgaa tatcttttcc 915601 ttcagacacc aaattccact tgcgcagttt gtcactcgtg ttcagcttca tcccgatttt 915661 tttgacaagg aagctcaaaa cagaagctgc agcccatcct aacagcagaa tgagtccggc 915721 tttcagcacg cttgggatcg cagctgcaat cgccgaaagc atactgacaa acggcgatgc 915781 cactgttgtc aggtgcaaaa tgttaaagaa taaaataaag acgatgatca gtgcgataaa 915841 ataaacgacc ttgcttatga ctttttccga ggaatagcgt gaaggctttt tcccagcaaa 915901 gagcttgtcg tcgatttttg ttttgctgag tcctttgtat accgcttttt caatgatttt 915961 agcaatagcc cagccgatta ataagacgag taaagcaatg attacgtttg gcagcttact 916021 gagataagaa gaaaacacgt ctgctacatt caattggtat cgctcctttt tcgtagtatg 916081 gtgtgtgttt acccacttat ccaataagca aacagatgaa tgtgccgggg gaattttttc 916141 ttgcccgagt gagactatca tcttttgtct ggcgggctca tacattatag ataagtccaa 916201 gtagggggga ttcggttgaa cgcggaggag aagaagggat tacagcgggc aattgaggaa 916261 attaccgaaa ttgcaaaagg attcggcctt gatttctacc cgatgagata tgaaatctgc 916321 ccggctgaaa ttatttatac atttggcgcg tacgggatgc cgacaagatt cagccactgg 916381 agcttcggca agcagtttca caagatgaag ctgcactatg atctagggtt aagtaagatc 916441 tatgagctgg tcattaactc agatccatgc tacgcttttt tgctggacag caactcactg 916501 atccaaaata aattgattgt cgcacacgtt cttgctcatt gcgatttctt caaaaacaac 916561 tgccgtttcc aaaacacgaa gcgcgatatg gtggaaagca tggcggcaac agctgaacgg 916621 ataaaacact atgaacaggt tcacgggata aaagaagtcg aatctttttt agatgcaatc 916681 ctttcgattc aggagcatat cgatccgtcg ttggtccgac caaagctcca atggagtgtg 916741 gatgatgagg aagaggagat tgaagaggca gccacgcctt acgatgatct atggtcttta 916801 gatgaaaaga aaccgaaaaa acaagtgaaa aaatcgaaaa aaccgttccc gccgcggcct 916861 gaaaaagata tcctgctttt tatcgaggag cattcccggg agctggagcc atggcagcgt 916921 gatatattaa cgatgatgag agaggaaatg ctttatttct ggcctcagct ggaaaccaag 916981 attatgaatg agggctgggc ttcctattgg caccagagaa ttatacgtga gcttgattta 917041 acctctgatg aagcgatcga gttcgccaag ctgaatgcag gtgtcgttca gccgtccaaa 917101 acaggcatta atccttatta tttagggctg aaaatatttg aagacattga aaagaggtac 917161 aacaacccga cggaggaaat gaagaaaatg ggcgtgcagc ctgactccgg ccgggagaaa 917221 atgtttgagg tcagggagat tgaatccgat atctctttca tccgcaatta tttaaccaaa 917281 gaattagtca tgcgcgagga tctttatttg tttcaaaaac agggccgaga ttataaaatc 917341 atcgataaac agtggaagtc ggtgcgcgac cagctcgtaa gcatgcgggt aaatggcggt 917401 tttccatatt tgacagtaaa cgacggcgat tatatgaaaa ataacgaact ctatattaag 917461 cattggtatg agggcataga gttggatttg aaatatttgg agaaagtgct tccttattta 917521 ttccagcttt ggggaagaag cgtgcacatt gagtctgtgc ttgaggataa ggaagtcatg 917581 ttttcgtacg acggaaaagg tgttcaccgc agatatttat aaaaaagagg atgcagcgtt 917641 ctgcatcctt tttattttcc agtttttaaa atcttaaata tgatgtttgc ctggtccgta 917701 ttgttaatca atccgcggaa tttttctttt ccggggccgt acgcgtatac cggtacttct 917761 tcgccggtat gatcggtact cgtccatccg ctgttggagc gggtattaaa aatcttgatg 917821 atggctttgg aggccccttt gcttttgtca gcctgtgcag ctgcttcaac gcttttgatt 917881 tcttcagatg tgactttcag attggcatag cgggcgagca catctttaac cggcttgcct 917941 tcactgattt ttttggccat gaattcaggt gttttcttag cggagagaat cggttctgcg 918001 tgccaattct tttccccgtt tgcgccaatg gtaaagccgc cggttgtatg gtcagcagtt 918061 gcaatcacaa gtgtatgttt gtcttttttc gcaaattcaa tcgcggcttt ataggcctgt 918121 tcaaaatctt taacctcgct catggctcct actgtatcat tgtcatgggc cgcccagtca 918181 atctggctcc cttcgaccat caagaaaaat ccttttttat tttggttcag gcgatcaatt 918241 gctgaaaccg tcatgtcttt gagagacggt gttttactgt cacggtcgag cgctttagca 918301 agccctccat ctgcgaaaag cccgagcacc tgctgatctt tatttttttt caatgcttgt 918361 ttagttgtca catagctgta gccggcttgt ttgaattcct ttgtcaagtt tctgtccttg 918421 cggttaaaat aagattttcc gccgccgagc agcacgtcta ttttatgttt gccttttatc 918481 ttgtcatcca tatagctgtt ggcgatttgg tccatgtttt tccgtgattc attgtgggcg 918541 ccatatgcgg ctggagtggc gtggttaatt tcagacgtgg cgacaagccc tgttgacttg 918601 ccttgctgtt tggcctcttc aagtacagat ttcacttttt ttccgttttt atcgacgcca 918661 attgcattgt tatatgtctt aacgcctgtc gctaatgctg ttccggctgc tgctgaatct 918721 gtaatattat agtcagggtc atccggatgc gtcatcatca tgcctgtcag gttccggtca 918781 aattctgtta acttcgggtt attcggtgtg tcaccgttat ttttcatgga acggtaggct 918841 cttatgtaag gcgtccccat gccgtcgcct atcatcacaa tgacatttct gatctcagct 918901 ttgtcttgtt ttttggcgct ggccttttct gtttgctgaa gctcagctcc ggcaaagatt 918961 ccagctgtaa ggacagaaac agcggcgatt ggcagaagtt ttgatttcat attttgaaac 919021 aaactcattt ttttcatgcc tcctttaatg tattccgttt atcatgttag ggaaactttg 919081 ttaaatgcgg ctgttgatca tgtaaacaat aagtaaagcc ttgtaaggaa atgaaaaaac 919141 gcttttcgtt atcttgcctt atttgatgta aagcattcat ttttcagaaa aatctttacc 919201 tctctgtctt tgcatgatat gtttgtttaa ataaaaaaac tgcggataac cacagctctc 919261 ctcgaatata ctttatcact catttttccg atatatgagc cgaccccgaa agtttttcat 919321 ttatttcctt tatgttgaaa aacatcccat aaaacatgac aaaagcactc gttttttgtc 919381 acctttgcaa tgaaaatgaa atatttaata cccttaaaaa ctttttttta gaacgaataa 919441 ttaagaaatt tgtcacatga agtcaagact atttctgatg ggaatctatc cttataatag 919501 aaatcaataa gattaattta aaaaaagaga tacatatata tagagttaac atttggggag 919561 gaaaatatga aaaagcaaat cattacagct acgacagcag ttgttttagg atcgacgtta 919621 tttgcaggag cggcatctgc acaaagcatt aaggtgaaaa aaggcgacac gttatgggat 919681 ctttcaagaa aatacgacac aacgatcagt aaaattaaat cagagaacca ccttcgttca 919741 gacattattt atgtgggaca aactttatcg attaacggca aatctacaag ttcaaaaagc 919801 agcagttctt cttcctcttc ttctacatac aaagtaaaga gcggggacag cctttggaaa 919861 atttcaaaaa aatacggcat gacaatcaat gaactgaaga agctgaatgg cttaaaatca 919921 gatttgcttc gtgttggaca agtcctgaaa ctgaaaggtt caactagttc aagcagctcc 919981 agctcatcaa aagtgtcatc gtcttcaact tctacttata aagtgaagag cggagacagc 920041 ctttctaaaa ttgcgagcaa atacggcact acggttagca aattaaaaag cttaaacggc 920101 ttaaaatcag atgtaatcta tgtcaaccaa gtattgaagg tgaaaggaac aagcacaagc 920161 agctcaaaac ctgcttcatc ttcatcgtct tcaagcagca aaacgtcatc tacatcactt 920221 aatgtgagca agctggtttc tgatgcaaaa gcgttagtcg gaacgccata taaatggggc 920281 ggaacgacaa cttcaggctt tgactgcagc ggattcattt ggtacgtact gaataaacaa 920341 acaagtgtgg gcagaacaag cactgcagga tactggagtt ctatgaagag cattgccagc 920401 ccgtctgttg gtgatttcgt cttcttcaca acatataaat ccggcccttc tcacatgggg 920461 atttacattg gaaacaacag tttcattcat gcaggatctg acggcgtaca aatcagcagc 920521 ctgaacaaca gctactggaa gcctcgttac ctcggtgcga aaagattcta atttttagag 920581 aaaacccgtt cattggaacg ggtttttttc attagacgga gcacaggcgt tttggttgct 920641 cctaaaaatg aaaatgtgat aaaaaatcca agaacttttt ttctttctta ttttcataaa 920701 gggcaatcgc gtaagcgccg gcatagggca gctgtacaga ctgataagga attctgatca 920761 tctgtttctc tgctaactca cgctttactg tagataaagg cagaaatgaa actccgagtc 920821 cttccttgat aaaccgtttc gttatatgtg tttgagtgac cttcattgtt ctcacaaatg 920881 gaaatgtcat tctgacttga cggagcaagt cgtcccagta atcaggatga ttgtgggtca 920941 aaagcaggta ttgttcgagc acctctttgg catcaatttc gttgtcttct atgaaacgct 921001 tatcgggcgg ggcaacaagg acgacagggt ctttgtataa gcagtggcag cttaaagaag 921061 aagactgtac ctttaaacag cttagtccga tatctgcttc cccggcttta atcagtgacg 921121 cgatttccgc tgattcgaaa atcgtaaccg ccatttctgt ttccgtattc attgctgtgt 921181 accgcttcat gacagaagga agcactgtat ctgcaataag cggagaaacc gcgagctgta 921241 aggtttgaga gtagccttgt ctcactctgt gaagctctgc catgctgttt tcataatcat 921301 caagaagcct gagcgcatac ggcaaatacg ccctgccttc atcagtcagc tggatttgcc 921361 tgcctttacg ctcgaacagc ttgcagctga tttctttttc taattgcttg atatgtacgg 921421 tcacagtagg ctgagataag aaaagcgttt ccgccgtttt tcggaagttc tcatattttg 921481 cagcggtcac aaaggtgtga agccatttga aatccatttc tattctccct ctgattaata 921541 tttttaatta attcccttta aaatattgat tattttttaa atattatatt tactataata 921601 acagaaaagg atagggggaa tacaaatggt acattacgga ttaaagggaa ttacatgtgt 921661 agaaacatcc atcagccata ttgatggtga aaaagggcgt ctgatttaca gaggacatca 921721 tgcaaaagac atcgcactga atcacagctt tgaagaagcg gcttatttga ttttatttgg 921781 aaaactgcct tcaactgaag aattgcaggt atttaaagat aagctggctg cggaacggaa 921841 tcttccggaa catattgagc gcttgattca atcactgcca aacaacatgg acgatatgtc 921901 ggtgctgaga acggttgttt cagcattggg ggaaaatacg tacacattcc atccgaaaac 921961 agaggaagca atccggctga ttgcaatcac gccttctatc attgcataca gaaaaagatg 922021 gacgcgcggt gaacaagcaa ttgcaccttc ttcccagtac ggacatgtcg aaaactacta 922081 ttatatgctc acaggtgaac agccttcaga ggcaaaaaag aaagcgcttg aaacctatat 922141 gattctggcc acggagcacg gcatgaacgc atcgactttt tcggcacgag tcacgttatc 922201 tacagagagt gatttagtgt cagccgtcac ggctgctctc ggtacgatga aaggtccgct 922261 gcacggaggt gctccttctg cggtgacaaa aatgcttgaa gacattggag aaaaggaaca 922321 tgctgaagca tatctgaaag aaaaactcga aaaaggagag cgcttgatgg gattcggcca 922381 cagggtgtac aaaacaaaag acccgcgggc agaagctttg agacagaaag cagaagaggt 922441 ggccggcaat gaccgtgatc ttgatcttgc gctgcatgta gaagcagaag cgattcgttt 922501 gctagaaatc tacaaaccgg gacgaaagct gtacacaaat gttgaatttt acgcagctgc 922561 agtgatgagg gccatcgatt ttgacgatga attgtttact ccgacctttt cagcaagccg 922621 aatggtaggg tggtgcgccc atgtactgga acaggcagaa aacaacatga ttttccgccc 922681 gtcagcgcaa tataccggtg ccattcccga ggaagttctt tcataacata ttttggcgtt 922741 tattcatttc tgtcgtgtgg taacgttcag tatcaaccac atgtctagga gtgatgaatg 922801 tgaacccaat ggacagacaa acagaaggac aagaaccgca gcatcaggac agacagccgg 922861 gcattgagtc aaaaatgaat ccgctgccgc tgtcagagga cgaggattat cgaggaagcg 922921 gaaaactgaa aggaaaagtt gcgatcatta ctggaggcga cagcggaata gggagagcag 922981 cagctattgc ctttgctaaa gagggggctg atatctccat tctatactta gacgagcatt 923041 cggacgcaga ggaaacacgc aaacggatcg aaaaggagaa tgtccgctgc ctgcttatcc 923101 cgggagatgt tggggacgag aaccattgtg aacaagctgt gcagcaaaca gtggaccatt 923161 ttggtaaact cgatatctta gtgaacaacg ccgctgaaca gcatccccag gacagcattc 923221 tcaatatttc aacagaacag ctggaaaaaa cctttcgcac aaatattttt tccatgtttc 923281 atatgacgaa gaaagctttg cctcacctgc aagaggggtg tgccattatt aatacgacat 923341 cgattaccgc ttatgaaggg gatacggcgt taattgatta ttccagcaca aagggtgcga 923401 ttgtttcctt tacgcgttcc atggcgaagt cgcttgcaga taaaggcatc agagtgaatg 923461 cggtggcgcc cggtccgatt tggacaccgc ttattccggc gacattccct gaggaaaaag 923521 tgaaacagca cggcttggat accccaatgg gaagaccggg acagccggtt gagcatgcag 923581 gcgcctatgt tctgctggcg tctgacgaat cttcctatat gacagggcag accattcatg 923641 tgaatggcgg ccgttttatt tcaacgtaat caacgaaaaa ccagctcaag agctggtttt 923701 ttgtgtggtg aaaaatttca aaataaaaaa tttgtcgatt tttctaacaa ttttgttttc 923761 atttttgcaa ttttatatat aatattgagt aggagaaagg aatgattcgc gaccagtaca 923821 aatatagtag aaaaaaaaga ataatgacca ttgttactca tgaattcaga aaattcaaat 923881 aaaatatata aaaatagatg atcgggagtt gaaggggaat gaaagggagc gtttttagga 923941 agaaaagcat tcaggattta atcgctgcga cgagcgggga aaagtcttta aaaagagaat 924001 taggggcatt tgatttaacg ttgcttggaa tcggcgccat tattggcaca gggatttttg 924061 ttctgacggg aacaggcgca gtcacggccg gtcccgggct gacgatttca tttgttgtgg 924121 cggcgttggc ttgtttattc gccgccctgt cttacgcgga atttgcgtca agtgtgcctg 924181 tttcaggttc ggtgtataca ttcacttatg cgacattggg agagcttatg gcctttatta 924241 tcgggtggga tttaatttta gaatacatgc tggcggtaag tgcagtgtcg gtcggctggt 924301 ctggttattt ccaatcgttt ttatcagggc ttggcattca tcttccggtt gctttaacag 924361 cggcaccggg cgcagtgaaa ggcaccttta ccctgtttaa tcttcctgca ttcgtcattg 924421 taatggcgat cacatatttg ctttatttag gcatcaaaga atcaaaaaga gtcaacaata 924481 tcatggttat cttgaagata ctggttgttc tgctgtttat cgcggtggca gccgtttacg 924541 tgaagccgca caactggcag ccgtttatgc caatgggctt tggcggcgtg ttcagtgcag 924601 cggcgctcgt attctttgct tttatcggat ttgacgctgt atcctctgct gcggaagaaa 924661 cgaaaaatcc cgcgaaggat ctgcctaaag gcattatttt ctctttactg gtctgcacga 924721 ttttatatgt caccgtatca gccatcatga ctggggttat cccgtttgct caatttgcgg 924781 gtgtggatca tccggtttct cttgttcttc aaagcgcagg gcaaaattgg gtggcaggca 924841 tcattgatat tggcgccgtg ttgggaatga caacagttat gctcgtgatg ctttacgggc 924901 agacccgcgt catgtttgcc atgtcgcgtg acggacttgt gccgggttca ctttctaaag 924961 tgcatccaaa gcacaaaaca ccttatgtag ccacttggtt tttcggaacg atgtcggcgc 925021 ttctcggctc acttgttccg ctggatgaac ttgcaaagct ggtgaacatc gggacgttgt 925081 cggcatttgt cctgatttct gtggcagtta tcgttttgag aaagaaacag cctgatcttc 925141 cgagagcttt taaatgcccg ggagttcccg tgatcccagg cctggcgatt ctgttctgcc 925201 tgttcttgat tttaaatctg ggatgggtga cgattgtccg cttcctagtg tggctgttaa 925261 tcggcttggt aatctatttc ctgtattcaa gaaagcattc aaaattaaat caataacctt 925321 ttgataaaga gagcggccat acaggccgcc tcttttctgt tcttggcaaa tgaatctata 925381 gaaatgaaga caaaaataag agataatata ggctggaaag gaagtgacgt ttattgtctg 925441 agcaaaaacc agtccaatgg gcttcgaaaa ttggtttcgt catggcagcg gccggctcgg 925501 ctatcggctt gggcgcgatt tggaagttcc cttacgtagc ggggaccaat gggggaggag 925561 ccttttttct tatcttcgtg ttatttacca tcctcttagg ctatccgctt ttggtggggg 925621 aatttatttt tggaagacgg aaccagacga atgccattga tgcatataaa aaagaagcgc 925681 cgcgatcagc ttggtttctt acggggtgga tcggcgtagc ggcgtgtttc ttagtgctgt 925741 cgttttacag tgtaatcggg ggatggattt tgctgtatat cgtgaaaaca gcgtcaggat 925801 cactgtccgg gctttctcaa gcacagtatg gcgctctttt tgcttctatt atccaaaatc 925861 cggtgcagac gctcgcggct cagcttgtct ttatggcact gactgtactc gttgtcgcaa 925921 gaggggttca aaaagggatt gaacgggtaa gcgcggtgat gatgccgatt ttgtttttat 925981 tgtttattct gctcgttctt cggtctctta cgcttaatgg tgcaatggaa ggcgtaaagt 926041 ttctgcttgt gcctcatttc ggcgatctga ctccggaatc catattattc gcgctgggac 926101 aggccttctt tacgttaaca ctgggggttt cggtgatggt gacctacagc tcctatttgc 926161 cgaaaacaca aaatatccct cgttcggcag cctccattgt cttgatgaat atcattgtga 926221 cactcttggc aggtttggct atttttccgg cggttttctc attcggtttt cagccaaatg 926281 aaggaccgac attgctgttt acagtgcttc cggccgtttt tgaacagctt ccgttcggca 926341 cattgttttt tatcggcttt ctcgttgcat ttttatttgc agccttaacc tcagcatttt 926401 cgatggttga aattatcgtt gccacaatcg gaaaagggga cgaaaagaag agaaaaaaac 926461 tgtcatggac gagcgggctt ttgatctttt tggtcggaat cccatgctgc ttgtcttatg 926521 gcgttttgag tgatgtgcac ctatttggca aaacgttttt tgatattgcc gattttaccg 926581 tcagcaatgt tttgatgcct tcaggcgctc tgttaatttc tctatttatc ccgctgaaaa 926641 tttcgaaaag cgaactcttg gctgaaatgc gaaatggatc aaatgcaggt aaagcattct 926701 tttacacatg gttttatttg cttcgtttta tcgtgccgct tgccattatt atcgtgttct 926761 taaatttaat cggaatttta tcattttaaa aaacaggctc cgtttccggg gcctgttttt 926821 tatttaataa gatgatatca acggtgccca tgccgttttc agtttttgga tgccgagcct 926881 gatgtcctct tctgacaaac cgccataacc gattaagaca gaagtaaaag gcgtctgttc 926941 tatatatgag ggagacacgg gatagagggt tacaccgtgg tcagcggctg cttgtattgc 927001 ttcttcctca cttgctggaa acaaaaggcg cagcagaatg tgaagccccg agttcttacc 927061 gagaatctca acggtgtttc ccagttcaga gcgaatggct tctaacagga cagcgtgttt 927121 ttttcggtat aagcttctca ttctatttat gtgtttttgc cactctccgg tttcgatgaa 927181 gtctgccagt gccaattgcg agtgggcaga aacggtctgc ttcattaact gaacattgtt 927241 ttggatcggt tccatgagtt cagggggcac aatcatgaag ctgagccgca aggaaggcag 927301 aagtgacttt gaaaaagtgc ccagatatat gactctgcca ttcggatcaa gaccctgtaa 927361 agacggaatg ggatggccgc tgtagcgaaa ttctccatcg taatcatctt ctataatgaa 927421 tgaatttgtt tctgccgccc atgccagcag ctcctgtctg cgggtaatcg tcataatggt 927481 cccaatcgga aactgatgcg aaggagtcgt atacatgaga taaggattct gacggtagag 927541 ctcatccggc aggacgcctt ctgcatcaga acaaatcgga gtgacatcca tgtgatttgc 927601 ttcaaacatc cttcttgaac ggtgaaagcc cggttcttca aagccgattt ttgtacctgg 927661 ctttagcgaa aggcaaagat tttgcagaag cacggtggtt cctgcgccga tgataatctg 927721 gccgggttca caatttactc cccgagacag cctgacgaat cgggcaatca tgtgcctgag 927781 ttcgtattct ccttgagggt cgccagaggt gtgaaacgat ccggaatagc gatcaagact 927841 ttttactatg ctttttctcc atgcgttaaa gggaaagagg gtcggatcaa cgctgccctg 927901 atggaagtca atagcaggtg cgtttttttg atgtaatccc ggctgtacag actgctgaaa 927961 atggtcagga gctgtcggga atcctggttc tacttccgcc gcgaaccagc cgattttcgg 928021 cttgcttttg acatagccct cagcagttaa ttgctcataa gctcgttcta tagttgccgt 928081 gctgacatcg agcaagctgg agagcctgcg ttttgacgga agtcttgttc cctttgtgat 928141 tcgcgcatgt gaaatttctt gtttaaaaaa ggtataaagc tgttcataca gcggtgtttt 928201 gctcttttta tcaagaaacg gcgtaatatc catctcatgt ctcctttgta gctggcatgg 928261 tcattttttc tgatattggc tatttggcaa atgccattta ttagctatga tcattgtaac 928321 gaaaggaaag gggattgaga agatgatcca tatgaaacaa ttaacctcga aagaagaatg 928381 ggctgagtcg tatccgatta tgagtgaatt gagaacagaa ctggatatag agacgtattt 928441 acaaaggctt gaagcctgtg tgcagaaaga atcgtatatg ctgtttgcct tatatgaaaa 928501 tacagcaatc agagcgctgt gcggggctct gccgagagtt tccattcata aaggagagca 928561 cttgtggatt gcggatcttg ttacaacggc accttgccga tcaaagggat acggcaaaat 928621 gcttttggat tatgcctcag actgggcgag aaaagccgga ctcggttttg tcagtctttc 928681 atctggcctt cagcgtaaag acgcacatcg attttataca gataaaatgg gttttactat 928741 agaaagttat ttgttccgaa aaccggtata acgaaaaaag acgcctgaaa aggcgtcttt 928801 tttaaaagcc aaactgtaaa ttcgtatcta cagatacaat ggtatacaca caaataatca 928861 caaagagatt aaggatgacg ccgagcaggc ctggacctgt gcgccctctc ttgatgaaga 928921 gttcaacaac gccgaacgga acggcagcca tggcgaacgg aagcatttga taggaataaa 928981 acgtgacgtt gctgataatg gccaaattca gcaacagcag ggacagaacc gctgtcccga 929041 cagagatcca gccgaataca ttgtgttctt taaaaattct taccagttcc ataattccac 929101 ctcgccgaca ttcgctgatt ttacagattt atttttcagc atgcgctgga tttccttggt 929161 tggccctgta acgaccgaac cgtatacatt gacaccgttt ttctctacat aatctaatcg 929221 gttatctaca ttcaggtctt tccgttttga aatgacctga gcccattttt cgtgtttgga 929281 catgaatttc agggcgttga taaactgatc gccattcgac ttgccttttg tattaagggc 929341 ggccaagaac tttgaatcct ttccaggata gccaagaggt tctgtggaag ctgtcttatt 929401 tgtgtttttc tctgtttcga ttgcgttcca caaaaagctc acatcatagc ctttgaattt 929461 gttatacacg tcttttgtcg gatatgcacg gtcatatgaa aggtagacct ctgataccgt 929521 tccttcaggc aatgtgctta acgttttttc tgcttttgcg gtcgtttgtt cagacttgtt 929581 tgaaggatgt gtaaagtaat ggccggtttt attcacttct aagtcatagt agtttactgc 929641 cggcgctttt actttgttat aaaacatttc aacccgttca ttccctacgg cagccgtctt 929701 cgtgccaatc tgcttttgca gcgggaattc cgtattcatt ccaaatagct tcacttggct 929761 tttcagtccg gaagtatcaa caagaacatt cggcatggtc agggctacag tgactgcggc 929821 agtttccata aactcattgc cggtgctgtg ttttccaccc attccgtaat agaggtagct 929881 tcccagcgta caaagcggca aaatcatcaa tgtcgaaatg acggcaagca cagaaattcg 929941 caaataagac ttgcgtttgc cgtaggctaa aatcgctttt tgtttttcag gactgatgct 930001 gagatcccaa tcgttatcgt cctctagttc gctgtcaatc agttcctgat atacttcaag 930061 cttctcgagt tcttcctcaa atgcagtcat ttcctggtcg ctcatttccc catttttata 930121 ttgatcaaaa cgctttttaa attcttcatt catcattaac acctctatta taaagtgctt 930181 tcagccgctg tctggcacga aataaaacac ttttaaaatt cgcctctgaa atattcataa 930241 tatgggatgc ttctttgtag tttaactctt ttaaataata tagcgttaag gcctcccgat 930301 aattatcggg gagctcggac atataaccag tcagcacttc ctttatctct acctgatggg 930361 caggactttg aacagcattt tgaaagaggc ttccgattaa gtcatcagaa atggttactt 930421 ctttcttatg ctttctgacg taatcaatga aggcgtttcg cgccacttga aaaagccagg 930481 gctttacttt gctgtgatca taggagtgaa tgtgtatgta tgcccgcata aaggtttcct 930541 gcagtaagtc ttcagcaaga tgcttgtctt ttgtcatgga gagcaggaac ctgtaaacat 930601 cattcatgta catttggtaa atttcatcga tcgtcactgc cttttctccc ctctatgtta 930661 tacacgcata agaaaggttt aaagttgcac attacatgca aacggctttt ttatacctaa 930721 tcaaacacca ttactatata gtacccaaaa atggccgcaa aagatagtgc ggagaaaggt 930781 ttaacatttt ttccagaggg gaaaagatag tgaaaaagtg aaggagtggc acaatggaat 930841 ataccagtat agcagataca ggaatagaag cctccagaat cggcctcggc acatgggcca 930901 ttggcggaac gatgtgggga ggcactgacg aaaaaacatc gattgaaaca atccgcgccg 930961 ctcttgatca ggggattaca ctgattgaca ccgcaccggc ttacggcttc gggcagtccg 931021 aggaaattgt cggaaaggca atcaaagagt acggcaaaag agaccaggtg attctcgcaa 931081 cgaaaacggc tctggactgg aagaacaacc agctgttccg ccatgcgaac agagcgagaa 931141 ttgtagagga agttgagaat tctttgaagc ggcttcaaac agactatatt gatctttatc 931201 aggtgcattg gcccgatccg cttgtgccaa ttgaagaaac ggctgaagtc atgaaggaat 931261 tatatgatgc gggaaaaatc cgggcgattg gcgtcagcaa tttttcaatt gagcaaatgg 931321 atacatttcg cgccgtcgca cctctccata cgattcagcc tccatataat ctgtttgaaa 931381 gagagatgga agagagtgtc cttccttatg cgaaagataa caagataaca acattattat 931441 acggcagttt atgcagaggg ctgttaacag gcaaaatgac tgaagaatat acatttgagg 931501 gcgatgatct gcgtaatcac gatccaaaat tccagaagcc ccgctttaaa gagtatcttt 931561 ctgctgtgaa tcaattggat aagctggcga agacacgtta tggaaaatca gtgattcact 931621 tggctgtcag atggatctta gatcagccgg gagcggatat cgctctttgg ggagcaagaa 931681 agcctgggca gcttgaggcc ctatctgaga ttacaggctg gacgctgaac agtgaagatc 931741 agaaagatat caatactata ttggaaaata cgatatcaga ccctgtcgga ccggagttta 931801 tggccccgcc gaccagagag gaaatataac aaaagctgag ggcgaatcct cagctttttg 931861 gcgtttaaac gagagaaatc ttaaaaatta gtaccaggta ataaaaaata ttgttataat 931921 agatgacaga aagaatcatt gattacgaca aaggaagtgc gatatgtata agttttgtgc 931981 aaatgcttta aaagttattc tttctcttcg cggaggagtg aaggtgtata acaaagaaaa 932041 ccttccggcc gattcaggtt ttgtcatcgc gtgtacacat tccggctggg ttgatgtgat 932101 tacactcgga gtcgggattc ttccttatca aatacactac atggcgaaaa aagagctttt 932161 tcaaaataaa tggatcggtt cgtttctgaa gaaaattcat gcctttccgg tagatcggga 932221 aaatcccggg ccaagcagta ttaaaacgcc gattaagctg ctgaaagaag gagagatcgt 932281 cggtatcttc ccaagcggaa caagaacctc tgaggatgtg cctttgaaaa gaggtgcggt 932341 gacgattgcg caaatgggga aagcgccgct tgtccccgct gcatatcagg gcccttcaag 932401 cggaaaagaa ttattcaaaa aaggaaaaat gaagctgatt atcggtgagc ctcttcacca 932461 ggctgatttt gcccacctgc cttcaaagga aagacttgca gcaatgacag aggctttgaa 932521 tcagcggatt aaagaactag agaataaact tgatcagcta taaggcgttc tgagagattg 932581 tcctgaaact gtgaaaataa gaaaagcacc ctatacaagg tgcttttctt attatgcttc 932641 ctgctggtta gctgtctcca gaagttcttc ttcttgaagc tttttcactt caatatatgc 932701 gacgtggtgg ccgtcaattt cattaatgat gaattcgcag ccctcttcga tgatggaatc 932761 atctttttca acatcgtatt tttgagtaag gaaccagccg ccgattgtat cgacttcttc 932821 gttctctaaa tggatgccta gcaggtcgtt tacttggtca attaacactt ttccgtcaag 932881 aatataatgg ccttcgccga ttttgcggat ttcgctaatt tcatcaatat caaattcgtc 932941 gcggatttca ccgacaattt cctcaatgat gtcctcaacc gtcacaagcc cggcagtacc 933001 gccgtattca tcagacaaaa tggccatgtg gaccctctct ttttgcattt tgacaagcag 933061 gtcttggatc ggcgcagatt caatgacatg aatgataggg ttgacgaatt gagaaatggt 933121 ggaatcaaca gatacctcac cgctgatgca ggcggtcagc acttctttaa tgttaataac 933181 cccgataatg ttatctttat cgccctcttc cacagggtag cgggtatatt tttcaatctg 933241 aatgatgtcc atcatttcag aaatcttgat atcatgcgga aggctgacaa tttcggtccg 933301 cggaatcata atttctttcg cgagcctgtc gtcaaattca aagattttat tcacatattt 933361 aaactctgat tggttgattt caccgctttt atagctttca gacaaaatga ttcgcagctc 933421 ttcttctgag tgagccagtt cgttttctga aacggtctcc aggccaaatg ctttggtcaa 933481 taaccgtgcg gaattgttca aaagccaaat gaatgggaac gcgatgcggt aaaaccaaat 933541 cagcggtttc gcaaacagca tagacactgc ttccgccttt tggatagcga ctgttttagg 933601 tgcaagttct ccgacaacaa cgtgtaagaa cgtgataatg gcatacgcaa aaataaacga 933661 tatgacatgt gaaagggaac ctggaacgtt catttggacg aaaagcgggt gaagcagcct 933721 ttcgatcgtt gattcaccta aaacccctaa tccgatggaa gtcaatgtaa ttccgagctg 933781 acacgcagat aaatattcat caagatgcgt ggtcactttt tttacggcta ttgctgcttt 933841 atttccttcc gcgatcagct gatcgatccg tgagcctctg attctgataa tggcaaactc 933901 agatgccacg aaaaatgccg tcagggcgat taaaacagca actaaaatca aattcactat 933961 gtccaattag aaccttcact ctagcaatga gaatgaaggt aacacctcct gttagataaa 934021 atggttttaa cttaacagca gcataaatga ttggaacacg gcgagctttt caggcgggag 934081 tttgcttttc agcttgtcac gatcctcggg cttcagccgt tcaaaccgat gcaagattcc 934141 ggagatgttt tgattcatat gatcaatttc taatgccaga tttccaattt catcatcaag 934201 tttagctgaa gagggaaact ggttctccag tcgatcttta atatcggaca gggccaatcg 934261 ctgcttcttg caatctacaa taaatataag tcgtttgagt gcattttcgt cgtagtaacg 934321 gtaatttgaa caggatctgg ccggcgtaag cagaccgaga ttcgtataat aatcaactgt 934381 ccgtttcgtt actccggcga gtgccgctag ttcactgatg cgataagtct cagccccatc 934441 tatatccctc ccaaccatca cgttatagtt atgagaatag tttaatatat gaacggtgtc 934501 ttgcacaagt ttattgtttt ttttagaccg gaattggaag ttgtggaatt catcatctga 934561 ttgaagtaac ataggaagat agaattttca aatttttata tgcggaaggg acagatgaaa 934621 ttggctgggt tatcccggga agttgaagaa aacttaaata aaggatcatg gattcgcaag 934681 ctgtttgatg aaggtgcaag gctgaagaag gagttcgggg aagaccaggt atttgatttt 934741 tcactcggca acccgattgt tgaaccgcct gaagctttta agagagcgtt aatagaggaa 934801 gctgaaaaag gcagccacgg atacatacaa aaccaagggc ttcttgcagc gagagaaaaa 934861 gtcgcgcaat ttctgggctc gcgttttgaa gctgatttct cagcggagcg catcgtcatg 934921 acggtgggcg cgggaggcgc tttgaatgtt gcgttaaaaa gcatcgtaaa ccctggggaa 934981 gaggtcatta ttcttgcacc ttattttgcc gaatataagt tgtatattga gaactacggg 935041 ggaaaagccg tcagctgccc gttgacaagc cggtttgaga tcgacattga agcggtaagg 935101 caatcgatca ctccacagac gaaagggctg attctcaata caccgcataa ccccacaggc 935161 actgttctca gccagaaaaa tatagacgat ttaggcgctt tattaaaaga aatagaagag 935221 aagagcggcc agacgattta tgtgctgttt gatgaaccgt acagtcaatt aatctatgat 935281 gaagagctgg caaatccgtt tcaatcgtac catcgtgtga tattggccag ctcattcagt 935341 aaagatctcg gcatagccgg agagcggctc gggtatatcg gattggacag ccgaatgccg 935401 gatgcggacc ttttgatcaa cgcttttgtg tattgtaatc gaacgcttgg atttgtgaat 935461 gcccctgtca tgatgcagcg ggctgtggca cgaatggatg atttaagagt agacgcgagc 935521 gcttataaag agcgccggga tttaatggta gacattttaa aagaagccgg ttttgaattt 935581 gaaatgccaa agggaggttt ctttgttttt ccgaaatcgc cgattgaaga tgaagttgca 935641 ttttgcgtgc atgccgccca aaaatacaaa ttattaattg tgccgagcag cggttttgga 935701 atgagcgggc atttccgatt atccttcagt gtgccgatcg agcagattaa aaactcacgg 935761 gacattttca tttctttata taaagatttt gcttaagaag gcaaagaaaa gaaaacagtt 935821 ttcaaggctg ttttcttttt atatccgcaa aatccttcct cttccaatcc agacaggcgc 935881 agaattgaca agcaggcatg cagttaaggc tttcttcatg ataaaagtct aaaaattaaa 935941 aatcattttt ggaatgagtt gtgttacaat aaaatataca atttataatc aaactttgac 936001 ttttggaggt ggtatgatgg ggccctctgc ttaggcaaca atacaccgcg tacctcaatg 936061 ttaaggaaaa atgattatat caggaggtga ctccttatcc tttgttgaga ggatagggtt 936121 aaatggacga tattgacagt ctgattttaa ttggcgtgct cattgcttta accgcgtttt 936181 tcgttgcaag cgagtttgcg attgttagag tgaggagatc cagaatagat cagcttatca 936241 cagaaggaaa caaacgggcg atactcgcaa ggcgtgtcat tacagatttg gatgaatatt 936301 tatccgcatc ccagctaggc attacattga catcaatcgg gcttggcgta ctgggtgagc 936361 cggcctttga acggctgctg catccactgt ttgaaccgct cggcttgccg gactcggttt 936421 cacatgcagt ctcttttgca gtcgcgtacg gcttgatcac gttcctgcac gttgttgtag 936481 gtgaactggc cccgaaaacg gtcgcgattc aaaaggcaga acagctgact ttactgatag 936541 cgggcccttt gcgtttattc tatttgctcc tgtttccgtt tatttggatc ctcaatggat 936601 cggcgcggct tttatgcggg atgttcggtt tgaagcctgc gtcagaacat gatggttccc 936661 attctgagga agaactcagg atgctgttat ctgagagttt aaaaaacgga gagattaatc 936721 cgtctgaata taaatatgtg aataagattt ttgaatttga taatcggatc gccaaagaaa 936781 ttatgatacc gcggaaggaa atggctgctg tgtcaactga gatgacgatg gccgagatgc 936841 ttgaagtcat gctgaaggaa aaatacacgc gctggccagt cacagatgga gacaaagaca 936901 gtgtgctcgg tttggtcaat acgaagcatt tgttttctga tttgctgttt atgacagaag 936961 aagaacgaat gaagatgacg atccatccgt atgtgaggcc ggtcatcgaa gtgattgaaa 937021 cgatcccggt tcatgacttg ctgattaaaa tgcagcgcga gcgcattcat atggctatat 937081 tgtcggatga atacggagga acctcgggac ttgtgacgac agaggatatt cttgaggaaa 937141 ttgtcggaga gatccgagat gaatttgatg aagatgaaca gccgctgatc caaaagcttg 937201 gcgacggcca ttatgtgatg gatggaaagg ttcggatcga tcaggtgaac agccttcttg 937261 gcgcatcgat tcaagaagac gtcgatacga tcggcgggct gatattaaaa gaaaacatcg 937321 atattgaggc tggtgaatcc attcgcatcg gttcatatac gataaaggtg ctgaagatgg 937381 acggccgatt aatcaagcaa atcgatataa aagaagaagc cggcaacaca accgggatta 937441 cggcgcacca caagctgccg ctgcccgagc ctgtgatgct gaacagtgca accttgagcg 937501 agaaataagc tcaaggtttt tttatattgt gattgtccag ccgcaccaaa atgcaaaaag 937561 cgacccgcaa agtgtcagga cgatgtacaa gatgctttct tttacacgtt tggccataag 937621 gagttgaata gtttcaacgc tgaatgtgga aaaggtcgta aaggcgccaa aaaaccccgt 937681 gccaatgata agcgagaccg aagcatttgc aacgtgaagt cctgtaaata ttccgagccc 937741 gagagctccg agaatattga ctgtcagtat gccaatgggc aggctgagac ctttggtttt 937801 ggcggttatg acattgccaa gccagaagcg aagcattgcg ccaagtccgc cccctatgaa 937861 aatacccgct agtgtcattt ttcctgcagc ccctttcttt gctgaatgcc tgctatgcgc 937921 cgtcccacaa aaacaccaat cagtgcaaat atgatccctg atatcaatga ggctgccaca 937981 tataaaagag ccaatgaggg ttgtccttgc aaaagcatca ctgtttcctt agaaaacgtg 938041 gacattgttg tgaagcctcc gcaaaagccg gtgcctaaaa aagccgacag cagaggccgt 938101 tttgccccga tcataaaaaa tccggtcaaa atgcctaata gaaggctgcc tgccgcattt 938161 tccagccagg ttgccgccgg gaactgaccg gtgtgtatcc ataagtttaa tccgtatcgg 938221 aggcaggcgc caagcgcgcc tccgataaaa accgcgctat atattttcat gtttgccatc 938281 ctttatgatg aaatccgggt aatctgtaac gatgccgtcc acgcccatgg cttgtaattt 938341 tgccgctgtc ttttgattgt tgacagtcca tgcaaatatg tttaagccat ttttattgat 938401 ggagccgatc atcagacggt taagccgtgt gtgttttata ttgacatagt ttgcaaaaga 938461 gcggaaggcc ttcatctgat ttctggacag catgccaaag ttgggccttg taatgaccgc 938521 tgtcggaatc gaaggataaa gctcgcggaa cctttggacg gagcggaact gaaaggattg 938581 aacaatatta ttgatagaaa aagaaaattg ccctaatagc tgtcccacct cttcttcaat 938641 tccgacttga gacggatggc cttttagttc aattaaaagg ccgatttttt tgtggtagcg 938701 cttgagcacc gcttccaggg ttggaatacg ctctccttga aaagcgggac cgtaccagct 938761 tcctgcatcg agtttttgca attcctccaa ggtaaaatcc ttaacaaagc ccgatccgtt 938821 tgttgttcgg tcaaccctgt catcgtgtat cacaacaatc tgcctgtctt ttgtaagctg 938881 gacatccagt tcgatcatat ctgcattcat tttcaccgca aggtcaaatg cggcaatcgt 938941 attttccgga gcgtagccgg atgctccgcg atgggcaatg atgtacaagc taagtcagct 939001 cctcgtatgg gcatttctgt tattgtatca aatccatata tgcaccgcga tacaaactgg 939061 tgaatttttt ctgccatatc ggaatggtcc gggctgagga atgcgtataa ctaaaaaaag 939121 acactcagcg tatcagaaca catttcgtca gaaaattagg tctttcgaca tgttcacaac 939181 aaaatatgat cctttataat agcaaaaaag gaggcgagat catgggaaaa gggagaatca 939241 gagtggagga aagaattaaa gccgaaacgg atgctgaaat gcaaaaagca actctccttg 939301 atcagacaca aacgaaaaaa ggtaagtgac tgtccctatt gaatctggct gatagatgaa 939361 ttgagaaatg accccggcgt ttcgccgggg ttttgtgctg cataagacat ttaaatgaac 939421 atccttacga atattttagt ataataaaca attgattggg atagagggga gacagtcatg 939481 ccggattatc tgcagcagta ttttacgctt gataacatca tacaaatcgg catcagcttg 939541 gcgattttgc tggtgtttct tatacttaga aaattattca caagatattt ttttaacctg 939601 ctttttaatt tgacaaaccg gccgaaaaca gaaattttta aacaggtggt tctggcgttt 939661 gataagccgg ccagatggtt ttttgttgcc cttgggctgt ttttagcgat ccggtattca 939721 ccgtttttag atgagcaaat gccggtcatc agcaaaatat accgctcact gattgtggcg 939781 ctcttgtgtt ggggtctttg taatttgacc gcaacatcgt cgtttatctt ccataaggtg 939841 aaccagcgct tcgagcttga catggatgac attctggccc cgtttttatc caaattgctc 939901 cgttttgtga tcattgcgct cagtgtcagt gtgatcgctc aggaattcaa ttatgatgtc 939961 aacggatttg tagcgggcct tggtcttggc ggactggctt ttgcgcttgc cgcgaaggat 940021 accatcagca acttcttcgg cggtattatc attattactg aaaagccgtt tacaattggt 940081 gactgggtgg agacgtcgac agtaacagga tcagtcgagg atattacctt taggagcacg 940141 agattcagaa cagcacaggg ggcgcttgta acggtgccga actctacgct gtcgatggaa 940201 gcgatcacga actggacaag aatgaccaaa cgccagatta cgttttccat ccatgtgtcc 940261 tacgctacgc cgattgagaa ccttgaacgc tccattcatt ctctcagaac aatgctctta 940321 gagcatgagg gcgttgataa tgaaataatc atggtcaact ttgatacgtt tgccgacagc 940381 tactacaatt tattttttaa cttctataca aaaacgacgg tttgggctga aaaccttaat 940441 attagagagg atatcaacta taaaattatt gagattttag gtgcagaagg cgttcagttt 940501 gcatatcccg gccaaatggt tgttgtcaag caaaagcacg aaagcgacca attccaggtg 940561 aatctaaata aagaggaaaa ggaacgggct taaaagagag acttcgtctg acagaggcgg 940621 agtctttttc atggtaaaat aagagaaaaa ggcggtgttg agttggaaac attcaaaagt 940681 attctacatg aagcacagag aattgttgtg ctgaccggag cgggaatgag cacagaatca 940741 gggatccccg actttcgttc agcagggggc atttggacgg aggatgcctc aagaatggaa 940801 gcgatgagcc ttgattattt tttaagttat ccgcgtctgt tttggcccaa attcaaagaa 940861 ttgttccaga tgaaaatgag cggcagcttt gaaccgaatg aaggccattt gcttttagct 940921 gagctggaga agcaagggaa gcaggtcgat attttcacgc aaaacattga cggtcttcat 940981 aaaaaagcgg ggagcaggca tgtgtacgaa ctgcatggtt ctatccagac agcagcttgt 941041 ccggcatgcg gcgcccgata tgatcttccc catttgctgg agcgggaggt gccggagtgc 941101 acggcggccg gaaacaatgg ggacatttgc ggaacggtat taaaaaccga tgttgttctc 941161 tttggcgatg ccgtcatgca ctttgacacc ctttatgaaa agctggatca agcagatctt 941221 ttattggtta tcggcacgtc tctcgaagtg gctccggcta gatttgtgcc tgaggatgca 941281 agcctgattc ccggcatgaa gaaagtcatc ataaaccttg aaccaacgta ttgcgacagc 941341 ttgtttgaca tggtcatcca tcaaaaaatc ggcgagtttg cccgaagttt gggcatgaaa 941401 aagtgagccg ctttatgcgc ctcacttttt tattcatgaa caggaaccat tgtgtcctct 941461 aacactccga aggaatagcc tttttctttt aatttattga ttagtaccgg cagcgcattt 941521 acagtagcag gaagatcatg catgagaatt acatttgggc ggcttgaaga gctgtgttcc 941581 atattctcaa gctgctgtaa tacggcggtc acatactgtg aattccggta tttccagtcc 941641 atgctgtcga tcgtccaatc ccagtacaca aacccatctt tctccagatt gcgaatttgt 941701 gaggcggtta gtgacggctt gcttccgtat ggcgttctga caagatcggt tttatatcct 941761 gtaatgtcct gcagcgtgtc acgcgcctcc tgcatttctt ttagcggaga tgtcggtgtt 941821 tgatagaaca atctgttatt gtgggtaacg ccatgtaaac cgagtgcgtg gccttccttt 941881 tctgctcttt tcacagcctg cttgaattcg ttcatccgcg gtgacagcat aaaaaacgtc 941941 gcttttacat cagcgctttt cagtacgtcg agcaagcggg ttgtaacggc tgaagggccg 942001 tcgtcgaagg ttaagtaaac cgttttatct cccatgttct gctttgtctg cagatgtttt 942061 atcaggagat cgggggagtc gtttttcagc ttaaggcttt ccttctcatc tcgaagctgg 942121 ccgtttgttg tgacagtgac ttcctttgct ttcgttgaac tgttggaata acccaaaatc 942181 accataagca aaagcagcac acataaaact gctaaacttg caaatttaaa agcaagcgaa 942241 actgcagaag gagaagcctc tcctctcgtt tgtcgcataa caatctctcc attggcataa 942301 aatctctaca taatgctgta cagcaggcag cttatgaaga tgccttatgt ttacaaccta 942361 tgtattacca gtcaagtata caggaataaa actggaaagc acatagaaaa tttgtcgaaa 942421 tgtcagattt taaggaaaaa ataaactcct ttccgctata gatctcttga tctttctgtt 942481 tttcagcttg tccaatatgg tagaattagt gataatgaca gcttgaatga catcagggac 942541 atctcgaaaa gggagggctt ttatgaaggt tttagtcaat ggccggctga ttgggcgcag 942601 tgaagcatca atcgatttgg aagatcgcgg ttatcagttt ggtgacggca tctatgaagt 942661 gatcagggtg tacaaaggag tattgttcgg cttacgtgag catgcagagc gttttttcag 942721 aagtgctgct gaaatcggaa tttcactgcc attcagtata gaagatctcg agtgggacct 942781 gcaaaagctt gtacaggaaa atgcggtcag tgagggagcg gtatacattc agacaacaag 942841 aggtgtggcc ccgcgaaaac accagtatga agccggcctc gagccgcaga ctactgccta 942901 tacgtttacg gtgaaaaaac cggagcaaga gcaggcatac ggagtggcgg ccattacaga 942961 tgaggatctt cgctggttaa gatgtgatat caaaagtctg aatttactgt ataatgtcat 943021 gacgaagcaa agggcctatg aagccggagc atttgaagcc attttactta gggacggcgt 943081 tgttacggag ggtacatcct ctaacgttta tgccgttatc aacggcacag tgcgaacaca 943141 tccggctaat cggctcattc tcaatggaat tacacggatg aatattttag gactgattga 943201 gaagaatggg atcaaactgg atgagactcc tgtcagtgaa gaagagttga aacaggcgga 943261 agagatcttt atttcgtcaa cgacggcaga aattattccg gtcgtgacgc tcgatggaca 943321 atcgatcgga agcgggaaac ccggaccggt gaccaaacag cttcaggctg cttttcaaga 943381 aagcattcaa caggctgcta gcatttcata aatgaacgaa gaaaagagcc cgctttttac 943441 agcggggctc tttttatttt ttaacaaatc caatcaaaat ggagatcatt ggcgatatat 943501 agaggaagaa cgtaaatggg atgtagtcta tgactggaac accaagtgcg ctcgccataa 943561 atgcgccgct gacgccccaa ggaatcaatg ggttaattaa tgttccgccg tcctctaatg 943621 atcttgtcag aaattttcgc tggatgtttc gtttgtcata taaagattta aatgattgtc 943681 ccggtattaa tatcgataaa tactgttcgc ccgttgccaa gttgacgccg atgcttgagc 943741 agacagttgc tgcaacaaga cggccttttg agcggatgcc tttcatgacg ccttccaata 943801 gtgcagaaat caatccgatt ttctccatca atccgccgag tgcaaaagca atcataatga 943861 gagagacaga gcccatcatg gattgcagtc cgcctctgtt aataatttta gcggctgcct 943921 cattgtcagt ttcgaaagtt gtgccatttt gtaaagctgt cataaacgcc tgcaggctgc 943981 tgtagggtac aaaaatagca gtcaaaattc ccgaggaaat aattccggca gtcagaacgg 944041 ggattactga tacccgtttc attgccagca aaacgactaa gagcggagaa agaagggccc 944101 acggtgtcac gtttgcagca tcttttattc cggttatgac ctgctgaata ttatcggttg 944161 aagcagcgtc cgctgacact gatgaaccga gaaagtaaaa cagaacgaca gtgatgagca 944221 aagctggaat ggttgtgccc atcatatggc gaatgtgttc aaagattggt atttcgccta 944281 ttccggctgc aaagttggtt gtgtccgaca tcggcgacat tttatcccca aaacaagcgc 944341 cgcatatgac tgcgcctgct gtccattcaa gcggaacgcc agccgcgctc gccacgccga 944401 tcagcgctac tccgattgtg cttacagttg tcagacttga gccaacaagt gtgctgatga 944461 tcatacatga aaacaaagca gtcaacagaa ggtggcttgg ttcaataaag gatagggcat 944521 aaactgtcat agtcggtatt gcgccgctgt acatccaggc gccgattaag atgccgatca 944581 gcgctagaac aataatcggc tgtacgccgt ttttgatccc gtctacaatc cctttttcaa 944641 tgctcttcca gggaaatcca aaccataaag ctgctgctga aagcatgaca acacttaaaa 944701 acagcgggat atgaggttct acatgaagca agaataagca agaaataata atgcacaaca 944761 tgaatataaa taaaccgacg gctaacggaa acgtcagctt tttttgagaa tccaaaataa 944821 caccccatat ttatctttaa tgcttttgtg cttttgggca cgaaagcatt ataacagaaa 944881 aaaacgaaaa tctatgtttt ttcacaatta tgaatataaa agaagtgagc acagggcgtg 944941 ctcactttac aatcaggacg ggtatatccg atttcgctga aagcttttca cttacacttc 945001 cgaatattag ctttttcagc ctgttttggt ctctgcttcc ggttacgatc atatcggcag 945061 aaatgcggtt tgcatgctcg ataattgatt cagccggatc gccttctaat atatcgatat 945121 ctccatctgc ctgctgttca ttcagcatca ttctggcttc ggcgatgact tcttccgtac 945181 ggtcttcata gatcattggc tcaggtgatg ttacatccga tatcagcgga tcaggaacac 945241 ttgtcatgcc tccgctgata tagcttgcct cagctgcggg tctgggcggg tcgatgacgg 945301 tctgattgtc tttcatatca tgtgaatggg cgacggtaat agcggcattt acggttttag 945361 caagatcaat ggctgtcaga agcgctttct tactattttc acttccgtca aacgcaacaa 945421 tgatacggtc agcatggaac atccttctca ccctttcaaa gcgtcttaca acactactac 945481 ccgaatttga gcacaattaa ccttttccta ttcaagtaat gattgacaat aaaaggtttt 945541 gtttatatga tgataaaaag atgaaatcag aatggaagga gggtttgcta tgccaaggaa 945601 tttgcgtgtt tatcaaacag tttcatattg gcgcggcaaa ccttttgttc tgttttcgtg 945661 aacggttttt taggtcggac cgcgcgctga aaagcgctgt gcgtaacata tcggttaaaa 945721 aaggcatgga gctgacgctt catgcctttt ttatatacaa aatctaagga aagacaggtg 945781 tatgggatgt gaagacaaat acagaggcga gggcagttcg tgccaaactg gatgaaaaaa 945841 gctgcaagga aaaaatagaa ggcggctgat gaggagatgg ggatagatgt tttcagtttt 945901 gaaaaagctt ggctggtttt ttaaggcgta ctggctgcgc tatacgattg cgattgtcct 945961 tttattagca gtcaatgtca ttgaaatgtt tccgcctaag ctcttgggga acgccataga 946021 tgatatgaaa gcaggggcat ttactgcgga agggctgctg ttttatatcg gtatcttttt 946081 tgtgctgacg gcggccgtgt atatcatgtc ttatttttgg atgcatcagc tgtttggcgg 946141 agcgaatctg atggagaaaa ttcttcgtac gaagctgatg gggcatttgc tgactatgtc 946201 gccgccgttt tatgaaaaaa accgaacagg cgatttaatg gcacgaggga caaatgatct 946261 tcaggccgtc agtttaacca cagggtttgg catcttgacg ttagttgatt ctacgatgtt 946321 tatgatgacg atctttttga caatggggtt tttgatcagc tggaagctga cctttgccgc 946381 cattatcccg cttccagtca tggcgattgc aatcagtcta tatggaagta aaattcatga 946441 gcggtttact gaggcccaaa acgcgttcgg ggcgctgaat gacagagtgc tggaatctgt 946501 ttcaggcgtg cgggtgattc gcgcgtatgt tcaggaaaca aacgatgttc gccggtttaa 946561 tgaaatgacc gctgatgttt atcagaaaaa tatgaaagtg gcttttattg attcactgtt 946621 tgagccgacg gtaaaactgc ttgtcggcgc aagctatctg attgggctcg gctacggagc 946681 gtttcttgta ttccggaacg agctgacgct tggagagtta gtgtccttta acgtttatct 946741 cggcatgatg atttggccga tgtttgcaat cggtgaactc attaatgtga tgcagcgcgg 946801 caatgcgtca ttagatcggg taaatgaaac tctttcttat gaaacggatg tgacagatcc 946861 aaaacagccc gctgatctta aagagcctgg agatatcgtt ttcagtcatg tcagctttac 946921 atatccaagc tcaacaagtg acaatcttca ggatatttca tttacggtgc gaaaagggca 946981 gactgtcggg attgcaggta aaaccgggag cggaaaaacg acaattatta agcagctttt 947041 gcgccagtat cctccaggtg aagggagcat tacattttca ggtgtaccga ttcagcaaat 947101 ccctcttgac cgtctccgcg gatggatcgg atatgtgcct caggatcatt tactgttttc 947161 acggactgta aaagaaaata ttttatacgg aaaacaggat gcaactgata aagaggttca 947221 gcaagccatt gccgaagcac attttgaaaa agatttgcac atgcttccgt ccggtctgga 947281 gacaatggtc ggtgaaaaag gcgtggcact gtcaggcggg cagaaacaaa gaatttcgat 947341 cgcgagagca ctcatggcga atccggaaat cttgattctg gatgattcac tttccgctgt 947401 agatgccaaa acagaggctg caattatcaa gaacatcaga gaaaaccgca aaggaaaaac 947461 gacatttatt ttgacacacc gattatccgc ggtagagcac gctgacctga tccttgtgat 947521 ggacggcggc gtcattgctg agagaggcac gcatcaagaa ctgctggcca ataatgggtg 947581 gtaccgggaa caatatgaaa gacagcagct gttcactgcg gaagaagggg gagcaggggc 947641 atgaaaatag gaaaaacgtt atggagatac gcacttcttt atcgaaaatt gctgatcaca 947701 gccgtccttt tgctaactgt tgccgtcggt gcagaactga ctgggccctt tattggcaaa 947761 aaaatgatag acgaccatat cctcggcatt gagaaaacat ggtatgaagc tgcggaaaaa 947821 gataaaaatg ccgttcagtt tcacggcgtc tcatatgtca gagaggaccg attgcaggag 947881 cctgtttcaa aagcaaaaga agcgcatatt tatcaagtgg gaatggcgtt ctattttgtt 947941 gatcaggctg tcagcttcga cgggaataga acggtttctg acgggaagct gacgatcaca 948001 aacggagaca agagccgggc atatgctgcc gaaaagctga ctaagcagga acttttccag 948061 ttctatcagc cggaaataaa gggaatggtg ttactgatct gcctgtatgg gggcttgctt 948121 gtgttttcgg tattctttca atacggacag cattatctgc tgcagatgag cgccaatcgg 948181 attattcaaa agatgaggca ggacgtgttt tcgcacatac agaaaatgcc gattcgctat 948241 tttgacaacc ttccggccgg aaaagtcgtt gcgcggatta ccaatgatac ggaggctatt 948301 agggatttat atgtcacagt gctttcaaca tttgtgacaa gcggaatcta tatgttcggg 948361 atattcacgg ctttgtttct gcttgatgtg aagcttgcgt ttgtatgtct ggcaattgtg 948421 ccgattatct ggctgtggtc ggtcatatac cggagatatg cgtcatatta caaccaaaaa 948481 atccgctcga tcaacagtga cattaacgca aaaatgaatg agtcaattca aggcatgacc 948541 attattcagg ctttccgcca tcaaaaggaa acaatgagag aatttgagga attaaatgaa 948601 tcacattttt atttccaaaa caggatgctg aatttaaact ccttaatgtc ccataatctg 948661 gtcaatgtca tccgcaatct tgcgttcgtc tgtctgatct ggcattttgg cggtgcgagc 948721 ctgaatgcgg cggggattgt ttctatcggt gtgctgtacg cgtttgtcga ttatttgaac 948781 cggttatttc agccgatcac aggcatcgtc aatcagtttt caaagctgga gcttgcaagg 948841 gtctccgccg ggcgtgtttt tgaactgctt gaagaaaaga atacggaaga agcgggtgaa 948901 ccggcgaagg agcgcgcgct ggggcgggtt gaatttcgtg atgtgtcatt tgcgtatcaa 948961 gaaggtgaag aggtattaaa gcatatttcc tttactgcgc aaaaaggcga aaccgtagcg 949021 ctcgtcggcc ataccggatc aggaaaaagc tcgattttga atcttctgtt tcgtttttat 949081 gatgcgcaaa aaggtgatgt cttaattgat ggaaaaagca tttacaacat gtcaagacag 949141 gaactcagat cccatatggg tattgtgctt caggacccgt acttattctc gggcacaatc 949201 ggatctaacg taagtctgga tgacgaaaga atgactgaag aagaaataaa aaatgcactg 949261 cggcaagtcg gtgctgagcc tcttcttaag aagcttccga agggcattaa tgagcccgtg 949321 attgaaaaag gcagcacgct atcctctgga gagcggcagt taatttcttt cgctagagct 949381 ttggcgtttg atcccgcgat cttgatttta gatgaggcaa cggcgcatat tgatacagag 949441 acagaggccg tgatccagaa ggcgcttgat gtcgtcaaac aaggacgcac caccttcgtc 949501 atcgctcacc ggctttcaac aatcagaaat gctgatcaga ttttggttct tgataaagga 949561 gaaattgttg agagagggaa ccacgaggaa ctgatggcat tagaaggcca atattatcaa 949621 atgtatgaac tgcaaaaggg acagaaacat tccattgcat aacgctcaaa aacccaaaac 949681 aatcgtgttt tgggtttttg gtttatgtag tcaataagcc agtccgacac ggtttccgac 949741 atactcacct gtaacgagct cacgatataa aaagtccgca gtatcgccga ccgaaatgct 949801 tgtgccgccc tcaggcaaaa cgttacgctc cgtacgataa acgccggttg ctgttccgtc 949861 cgggaggtaa gtggggcaga tgattgtcca gtctaatgat gattctttaa gcatttcgta 949921 tacttttgca tgctccttgg ctgcgcgggt ctgctttcgt ttcgattcat ttgtttcaaa 949981 ccggtatttt cccggttcat atcgggaatc taggatccct gcggtgccga tcgtaataag 950041 ccgtttgata tgctgttcct ccataacgga gagaatgtgt gccatagcag ttgacaaggt 950101 atcatcacca tctgtgccta gacagctgat cacgatttca gcattctcca ttattttttt 950161 cacatcttct aagcggcggg cgttccccat gacagttctg tcttttgaaa ggggaagatc 950221 agcatgttga gatctgatca gagcgaaaat atcaaatctt tcatctgctg cagcttgtgt 950281 taaaaaggct tgtccgacgc ggccgctggc tcctaataaa gcgattttca ttaaaaaacc 950341 tcctcgcctt tcattataaa aggatgttct cagtttgaac agcgcgggaa agaatacctg 950401 tacaaataaa cagaacgatg ggaaacatat tcatgaatca tggatacact tacgaattga 950461 accagctccc aattcacaat ggtgatgaat gacaccccga ttccctccct ttttttctag 950521 gatatgtgga gcaggaaaaa agggtgacaa aataaagaga gcgcggaaac cgcgccctct 950581 atagccatat attgaattgt tattgaactc tgccgcccat ttgctgctga gcgaaagata 950641 ctaaacgttt tgtgatttct cctccgacag aaccgttagc gcgagaagtt gtgtccgctc 950701 caaggttaac gccgaattca gaagcgattt caagtttcat ttgatcgata gcctgagctg 950761 cgccaggaac tagtaagtca tttgaagagt tttggttagc catgtgtaaa atctcctttt 950821 tatttagtat ggttgggtta actggagttg caccaatctg tgaacccttc tcgggtgtca 950881 ctgccgcctc ggcgtaaccc aatgctttgc cggcttgtta ctacgtatta tgttaaaatg 950941 gccggaaaat catgcggaga attgtgtggt aaatcttgag aaataaaaaa agcttagccg 951001 tttaggctaa gctagtcata aatatgaaaa agcatcagtt catgtatctc gtttgtaaga 951061 gcaggctcgt cagcgcgggc gggaaacaag tctccccatt caatctcacc gctcttatga 951121 tagatgcctt cataatgggt ccctttataa taaaatgaaa ttttccatcc gggcagcttt 951181 tcttttggga acaaaggttt ccagctgaaa tgagaaatca ttacggccac gctccttaca 951241 tttggtatca attgacctaa ataaaaacgg cttatgttca ttgtatcatt gtttcagaac 951301 atcattgaag aggcctaaat atgcagtttg tcccagcttt ggataaagat aagcccgctt 951361 tattaaaaaa gcggacaggt tacgaaggcc acaatgcttc cggagatgtg attgccttct 951421 cagataaata tgacgcgtat tcaaaacttc ttcgttttgt aagagaatca acatgatgca 951481 aatttggatg agaaaaaatg cttcggcccg ggcgcgaatt cgcttcaaac atccatactt 951541 taccgttctg atcaatgcca aaatcgaaac caatctcccc gataaatccc tcgatatgat 951601 catgaaggac atggcttgca gtcagtgccg ctgcagaaag ctttttaatg acctcaactc 951661 tttcagcggg atcatcgtat acttccgcaa gtgtctttac agtgccgccg ttagaaagat 951721 gtgttgtaat gctgttcttt ccggaaattt ttacggcgat tgctgtcact gtccattttc 951781 cttttctgtt tttattggta tggacacgga aatccgctgg tttgccttga aattcgatga 951841 gatcaacacc ttgctgaatg agaaagtcgg acgggttgtg atgtttttga aattctgcaa 951901 ggaatgaggc ggcatcggaa taatcaattg atgtaaaagt tttggcgtca ttcgtatgct 951961 ttaccgtcag gccgccatct gttcttgtca gctgataaat gccggtgccg agtgctccat 952021 ttgccggttt gatatagact tttttgtatg cgccacagag ctcatctatc agctccacag 952081 acggtgtcag ctcggatcta ggcaaaaagg gtgccgttct tggatctttt tcgagcaatt 952141 gatgaacgtt ccatttattg aaaaacgttt tattaaacca tgggatctga tattcatcga 952201 tcagcctctt ttttgtatgt tgcaagagaa gtgaatcttc aatttttcgg ttcggcaaac 952261 ggtcataaac gacgttcggc aatggaacga tttttttctc ccagccgttt tccctgtaaa 952321 ggaggccttc aatcgtgcct tcctcccaat tgatttggtg cgcgccaaaa acgaagcagt 952381 agcccccggc ttgctcgtgt aacgtgacaa gtttagaaaa aaagagggaa cgatccttaa 952441 atgggcgttc aagagataca gtaaaccctg ccgtaaagat gccgactaac ggcccgatat 952501 gcactgtatg atcatgaatc agtatatctg ccctgcttcg gtggggaagc aaaagctcat 952561 gaaacagatt ttcagagaga agcacggttt gttccagatg ccgtctgtaa gcaacgtggc 952621 atctgacaac cttcgttccg aatgcggcat gcaaaagtcc gtcttgcttc agcgaagagg 952681 gcagaaacag ggtgttttca ctggttttgt ctatgccgat caaaaaccgt ttaggattca 952741 cgcggaagaa ctcctttctg gctttgctca gaaaacagat attggcagcg ttttagggga 952801 caagtgtaca gctgttcttt ttgctcggga gagacacgca ggattgactt cctgcctggt 952861 ttggaattga tatctaaaat ccaaattctc ccgtcctttg caagacatat atcaagaccg 952921 agttcaaaca acggcccata gcgctcgtca agataatacg gaaccgattg ggtaattgaa 952981 aacacatcat ctagtaaaac cacttgctgt tttttcggta tatcttcaaa ccaggagtca 953041 aatgtcagcg catcagatcc gcctgacaaa ttggccagca gcccgtgttt gtatccgcgt 953101 cttactgcct ttccgactgt attccattca cctgcttcgt ttttttccat aaacagacga 953161 atatcacaag ggtattgttc cttatcttga atgtttaagt aaggctgaag caaatattga 953221 tgctgaagca cttttttgca ccatgtttta aaagaagtct ggttggaaaa cgtttttgtc 953281 tgcttatcct ttccgatgtg ataagtagca gtgatgtttt tcttgcccag cttcaaaaga 953341 atcacgcctc tgcctcccgc gccgaatgcc ggtttaagga tgcaggcttt ttctttggat 953401 aaaaaggagt gaatttgttc gtagcggctc acctttatcg tttcgggaat atagggattg 953461 attacagagt gctgctgcaa atcgtgaagg acggtccact tatcgggaag accccgcccg 953521 ataaattccg ttttcggata ttttttgagc cactcaacga ttggttttgc tttttgggaa 953581 tgtgaatcct tgccgtaaaa acagcgatca taaatataat ctggaatcgc catttcagtt 953641 tcgttccatg tgctgctggc cgaatgatag accgatgctt tgacacgcaa agtgtcaggt 953701 gaaatatcaa atggtgtaaa ccggatgaaa cgtatgccga attcgggtgc tcttttggcc 953761 agttctgcgg aataatccgc ttcatgctgg cgggataagg acataaaacc gagtgttatc 953821 atggtgagac tccccctttt attcaaaagc tgccggcggg tgtccgcagc tttacactaa 953881 atacatgtaa gacgaacgca gctgacggta ttctacttta cagaatacga ttctccacct 953941 tgccctattc caaaagaaca agctgatttt ctaagaacag gaatttgtct cctcgtttgc 954001 taagtgattg catgagcctc tataatacgt ataggtacat aatctatatg aaaaaagctg 954061 aagcacagat ggaggaagat gaataggaat gggtattgca ggaaccttta tttttatgat 954121 cgtgatcggc gctgccattg gagcggtgac caatcattta gcaattcaaa tgctgtttag 954181 gccgtataaa gcgtactatt tgtttgggaa acgagttcct tttacgcccg ggctgattcc 954241 aagacggcga gatgaacttg caaaacaaat gggactgatg gtagtcaatc atctcttaac 954301 ccctgaaggc attaaaaagc ggctcgtctc tgatgcagcc aaaacgcagg ctcttcgagt 954361 gggggaacag ctgattcaaa agctgtcact ttctgaagtg acagtaaaag aagcgcttga 954421 aaaagccggg atgaagcgcc ccgaaaaagc tgctgatgca tggatcagca gctggaccga 954481 tgataagctg catgagcttt tccgccaata cggggaccaa tcgttaaaag agctggtgcc 954541 tatagaggtg caggaaaagc ttgaggaaaa aattccgatg atttcaggat atatattgtc 954601 acggagtgtc cgttattttg aaagtgatga aggaaaaatc cgtcttggca atatgattga 954661 tgacttttta aaagagcgcg gcatgcttgg aagcatggtg caattgtttc ttggcaattc 954721 aagccttgcg gatcgcgtgc tgccggagct gctgaaattc ttgcgcaatg aggaaacaaa 954781 taaattgctt tctgatctct taaaaaacga atggggcaag ctgagggagt atacgtttaa 954841 tgaagcagat gaaaaatgga atgcaaaggc gctcattttc agtttgaaac gaagagtgct 954901 gcaagcattt tcgactgccc ctttcttcaa caatacgatt ggcacgctta ccgtccgcta 954961 tgaatctgag ctgacccagc aaatgctgcc ggcactatta gacaaattgc ttgaaggtat 955021 ttcgtccaac cttgaaagtg tcttaaaacg gttgcgtctt gaggaaatcg tcaaggagca 955081 ggtggatcag ttcccggtgg agcgtcttga agaaatggtg ctgtccattt caaaaaaaga 955141 atttaaaatg attacctatt tggggggcct tctcggcgga attataggcg cgattcaagc 955201 attgtttgtc atcctttttt aagaagaaat ggtttttgat taatgaaagg agctccatag 955261 tctgttatag tggagtggta tgtcaaacgg caatgatgaa aggagctatt tacaatggct 955321 gttaattttt atgatgtagc gtatgatctg gaaaatgcat tacgcgggag cgaagaattc 955381 acccgtttaa aaaaccttta cgacgaagtt aacgcagatg aatcagcgaa gcgcatgttc 955441 gaaaacttcc gtgatgtaca gcttagactc cagcaaaaac aaatggcagg agaagagatt 955501 acacaagaag aagtgacgca ggctcaaaaa acagttgcgc ttgtacagca gcacgaaaaa 955561 atttctcagc tgatggaagc ggagcagcgc atgagcatgc tgattggtga attgaacaaa 955621 atcattatga agcctttaga agagctttac ggcagtgttg aaggctaata agcaaaatcc 955681 cttcttggat aagaagggat tttttattca ctcagcaaac ttggaaatcc aatgaatctt 955741 ttacctctcc attgatgatg actgataatg tatgaattcc tttgtaatgc tttctggtgg 955801 ttaaatcctt aaaggattgg attcttgtgt atgacttcgt ttcgtttttt cgtatatttg 955861 tttctgttat tttaaatact ttctgatgac gctggcctct tgcttttaca aaatcaattg 955921 cgtactcaat tcttactttt tgatccctgt ctgaatgaat atagaaagaa aattcaaggc 955981 tttcgccaat aactatacgt ttgggctggc atgttaaatc atgtagttgt atcgaatcag 956041 cattttcata accaaaaagc gctaaggcct gtttatcacc cttttttaat aaggtccgat 956101 aggcgtgttt gataatccag tctgtatggg gatgtgttcc gtaccattga tctgcgactt 956161 ttctcagtaa atgaggatgc gtttttgata tatcattaag gttgttggcc acgctttttc 956221 ttacatataa agactcgtcc tgcatcagct tctcaaggat cggcaatacg ggggaagggt 956281 ccgatttcaa agccggtatc gattttcccc atggcaggcg gggcctgctg ccttcgctcg 956341 caagtcttct cacgtgttca tttttatgct cagaccatgc aagcaattgt gcaatcatct 956401 tttcttgatc taacagcaaa aaaggcctta cagcaaattc tgaggtcgaa tattgcgtaa 956461 aggattccaa tgcctttatt gattcttccc aatgcgctaa cccgtactgt tccacataat 956521 ctggaaataa aattccgctg agtcctttaa aatgaggggc tgtatcccgt aaaattgtga 956581 gcgcttcaac gtattgtttt ggcaaagttt cgtataaaga aactgtcacg cggcgcatcc 956641 gctcttttaa agtgagttca ggccagtcct ccagccgtaa tgtatccaag aatctgtttt 956701 tgttaaaatc aggataggat gaccttacat gatggatcaa ctgagatatc agttcttcat 956761 tatatatttc ttttaaatca gccatataaa caccgctttt tcgtttatta tttatattgt 956821 atgggaatgt acgttctgga tcaagtgtat agtcctaaaa attaacaact gatcctacca 956881 cggatataca aaagttggtt acttttttta gttaaaaaaa cccttgtcat cggaaaggaa 956941 aactgagata ataacattga aagcgcctac acttacctat ttcaaatgga tacggtcgca 957001 tatcatgccg ttatatagag gggataagca acagagagta agtgttcgga gcgcatcatt 957061 ggtcaaacaa ggggttcctg atacatgatt tttcgtaaat cgaaataacg atattaggga 957121 gaatggctgc ttcgatcgta tcctatcaac aagccataca taaagtctgc tgagccaggc 957181 tttttttgct ttaagaaaag gttgttctaa acacagagac agggtcatat cctatacaca 957241 agtacagtca tcaaggaggg ggacatctct gtgtcaaaac aattgcttgc cttaaatata 957301 gatggagcgc tgcttcggtc gaacgggaag attcatcagg caacgaaaga cgcgattgaa 957361 tatgtaaaga aaaaagggat ttacgtcaca cttgtgacca accgtcattt tcgctcagca 957421 cagaaaatag cgaaatcgct aaagcttgat gccaagctga tcacccatag cggggcatat 957481 atcgctgaga aaattgacgc cccgtttttt gaaaaaagaa tttctgatga tcataccttt 957541 aacattgttc aagtgctgga gagctatcaa tgcaatattc ggcttcttca cgaaaagtat 957601 tccatcggaa acaagaaaaa ggtgaattcg aatttattag ggaaagcact cattcatccg 957661 tctgacccga tcttttatcc agtccagttc gttgaatcat taagcgatct cctcatggat 957721 gagccggtga gtgcacccgt catcgaggtg tacacggagc acgacattca gcatgacatt 957781 acagaaacga ttacaaaagc cttccctgcg gtggacgtga ttcgcgtaaa cgatgagaaa 957841 ctgaatatcg tcccgaaggg tgtctcgaag gaagcgggtt tggccctcgt cgcttcagag 957901 ctgggcctga gtatggatga tgtcgtggcc attgggcatc agtatgacga tctgccgatg 957961 atcgaacttg ccggtcttgg ggtagcgatg gggaatgccg ttccggaaat taagagaaag 958021 gcagattggg ttacaaggtc caatgacgag caaggtgtcg cttatatgat gaaggaatat 958081 ttccgaatgc agcagcgaaa aggatttctt gataagttcc acatgaaacg tgtgtaaaaa 958141 agccgctcgc gccctgacag gtgcggcggc ttttttgccg gattgatttt agcagtttat 958201 ttctgtacac taaagaaagt tttgaatctg ataaattagg tgatgaagtt gcaaattaaa 958261 atagaaggca tacatgatga ccgcctgcat cggcctctgc aaaatattgc aaatttgttt 958321 tatgaagagt gcgagcttgc gtatggcgga gaggagcccg cagattttgt catttcttta 958381 gcgttgtcac aaacggatga gcatgtgacg gtttctggag aagtgaaggg tactggcata 958441 aaggaacagc atacaaaatt cttttctcca gacatgactg aaaaagaagc ttttaagcaa 958501 gtgaaaaaca caatttctta tgtgtatctc aatcttcttc aggcgcatac gggcattacg 958561 cagaagtggg gaatcctcac aggaatccgg cccacaaagc tgcttcataa aaaactgcaa 958621 agcggaatgt ccaaggagca agcgcatgct gagttgaaaa aagactattt aattcatgat 958681 gaaaaaatca tgctaatgca ggaaattgtt gaccgtcagc tggcggcagt gccggatttg 958741 taccgagtaa aggatgaagt cagcatttat atcggcattc cgttctgccc gacaaaatgc 958801 gcgtattgca cattccctgc gtacgctatc caaggacagg cgggcagagt cggctcattc 958861 ctatggggac tgcattacga aatgcagaaa atcggtgaat ggctgaagga gcatgatgtt 958921 aaggttacaa ccatttactt tggcggcggg acgccgacaa gcattacagc ggaggagatg 958981 gatctgctgt atgaagaaat ggtccgctcc ttcccggatg tgaaaaacat tcgtgagatt 959041 acggtggagg ccggtcgtcc tgacacgatt acagaagaaa aactcgccgt tttaaacaaa 959101 tatgacattg atcggatcag catcaatccg caatcctacg aaaacgaaac gctaaaggcg 959161 atcgggcggc accatacggt tgaagagacc attgagaaat atcatctgtc acgccagcac 959221 ggcatgaata atattaacat ggacttgatt attggtttgc ctggggaagg cgtgaaggag 959281 ttcaggcaca gtctttcaga aacagaaaaa ctgatgccgg aatcccttac cgttcatact 959341 ctttcattta aacgggcgtc agaaatgacg agaaacaagc ataagtacaa agttgccggc 959401 agggaagagg tttctcaaat gatggaagac gcggtagcct ggacgaaaga gcatgggtac 959461 gtgccttatt atttataccg ccagaaaaac attcttggaa accttgaaaa cgtcggatac 959521 tctttgccgg gacaagaaag catctacaac attatgatta tggaagaggt gcagacgatt 959581 attggcatcg gctgcggcgc tgctagtaaa tttattgatc gggatacagg gaaaattacg 959641 cattttgcga atccgaaaga tccgaaatcg tacaatgagc gcttcgagca ctacacggac 959701 gaaaaaatca aatatttaga gcagattttt gaaaaaacga caaagcagca ctgattacag 959761 tgctgctttt tttatccctg tttttttgcg ggctgaacct caggcttcca tttaaatacc 959821 ttgttcagca agcggtaaat tcgttttgat tcctttgtga caagcggtcc caaaatcgcc 959881 agaatgagga catataatgc ggcaaacggc tttaatgtgg ccgacagtcc gccggctatc 959941 ccgagattcg caacgataat cgaaaattct ccccgcgata cgatcgtcag cccgatattc 960001 gatgaagcct tatgagaaag ccctgcgcgt cgtcctgcca ccattccggc gataaaattt 960061 cccagaatgg tcaaaatcac tgcacccaac gcaagccaaa ccgcttcacc aagcgaaaac 960121 ggatcgatgc tgaggccgaa gctgaaaaag aacatcgcac cgaagaagtc gcgaaacgga 960181 acaacgaggt gttcaatcct atcggaatgc tctgtttctg aaaagaccaa accgagcagc 960241 agcgcgccga ttgcttctgc tacatgaatc gtctctgaaa aaccggcgat aaaaaagagt 960301 gctgcgaaaa tgacgataat aaacacttcg tttgagcgaa tgtccaacag tttgttcaac 960361 agcggcggga gttttcttgc tgcgataaaa aacagcagca tataaccgaa ggcgatcaaa 960421 atggacaaga gtgcactccc tacggatgtc gcatcaccta gtataaggcc ggaaacaacg 960481 gacagatata cggcaaggaa aatatcttca aacatgatga tgccgagaat caattcggtt 960541 tccgggttgg cggttctttt taaatcaacg agcacttttg cgacaatcgc acttgacgag 960601 attgtgatga cgcctgcgag gatgaggact tccagaaagg aaaatccggt gataaacccg 960661 taaagcagtc cgaggctgaa gttaatcaaa atataaatcg tcccgccgac cgcgattgat 960721 tttcctgatt tgattaactt cccgacagag aattcgagtc cgagatagaa gaggaggaac 960781 agtacgccca ttcgcccgaa aaactcgatg atttcactgc tttgaataaa tgttagatca 960841 ataatcccca ttttcggcgc gtgcggtcca acaagcattc ccagcacaat cagaaacgga 960901 ataatcgaaa atttaatttt attggcgatc acactggcga ttgccacaag cacaagtgca 960961 gttccgactt caaatacaag atggtccatc ggggctcaca cgccctctcc agaaagaaaa 961021 tcgtgaatca gtttcttcag atgctttctc tcacctgaga ggacaagggt gtcattttct 961081 tcaataatcg aatccgctcc gggatttagg agcttttcct ggttgtgttt gataatcgca 961141 ataacagtga catcgtaatt ctggcgaaca tcaagctcac cgagtgtgcg tccgatcgat 961201 ttggcgcctt tttcgacctt aaaccattca ataataagat cgctgaaggc catttcgatg 961261 gactccagag cttgcggttt atagaccatg cccccgagaa tagctgcaat ttgccttgct 961321 tcagaatcat ccaatgaaat atttgaaaga agctcatccg ggtcccggtc attaaaccgg 961381 taaatttccc ttcttccgtc atcatgaatg ataatcgtca ttttttcgtg gcttcttgtt 961441 tcgatttcaa actttttgcc gatgcccggc agatcgtttt ctttaatatt caatgaaaat 961501 ccctccgaat gtagtgttgg cagtatgggg tgagttacaa ataaaacttg agcaaattat 961561 attcggaggt aattagactg gtatttgaca gggacggcca aagccttttc cagcctgttt 961621 atcagcggtt cgtcaagtgg tttgacagag agctgcctga cagactgcgc cagcgggctg 961681 tactctttga tcagctcagc cgggtgcatg ctgcccggcg atggcgtttt tgccgattgt 961741 gtttcctgcg gatatgaaga cataggcaca tagctgtcag tgcttgcttc aaactgggaa 961801 ggcagaacca cgtccgaagg gggaaagtac accataaata aacttaacag aaaactgatc 961861 agcaatttat ccatgttcct ttcctccctt ctcatcaaga tatcccttct ttttcactat 961921 ataaaacttt atgtttccat tcaaacaata tgcatttttc agtatctatt gaccttgaaa 961981 aataaaaagg tttatttggg gatggcgggg aatgtatagg agaaagaaaa aagtaagcgc 962041 atacatggag gtgcttttaa tggagtttgt tcaatatgca tgtaatgggg ccgttgcaga 962101 gattatcctg aatcggcctg atgcccatca cgccctgaat gaacagatgc tgtctgaatt 962161 gaaggaggca gtcgaaatgg cggctgcaag cgaggcgctc atcgttctcc tgagaggaag 962221 cgggaaaggc ttttcggccg gcggtgatat caggatgatg acgtcagagc atgaccctga 962281 ccaatttaaa cggctgatgg atacgattga ggctgtcacc ctgaatttat atcagatgaa 962341 gaaagtgaca attgcagcca ttcatggtgc tgctgcggga ctgggcctga gtttggcgct 962401 ttgtgcggac attgtgctcg ctgaaaaaaa cgccgttctc gcgatgaatt ttatcggcat 962461 tgggcttgtt ccggacggcg gaggacatta tttgctgaag aaaagaatcg gtgaagcaaa 962521 agcgaaaaaa ctgatttgga gcggaaaaaa actatctgcc tcggaagctg ccgatatggg 962581 gcttcttgat gggacatttg ccggagaccc tgccgaaggc gcaagaccca ttatcgaaac 962641 cctgttggcc tcccctcttt tggcgatgat cgaaacgaaa ggtatttttc aaagcctcca 962701 aattgaagaa ctgaaaaaag tgctatccct tgagcgcagc gcccaagaga gaatgagaag 962761 gaccaaggat caccaagaag gaatccgtgc ctttttagaa aaacgggagc cgaagtttca 962821 agcgtaacag atcagccgga aagctgatca tctgtgaaac aaaatcagct ttccggctgc 962881 attgactaaa cgatgagtat gactatgaag ctctttttct tttaagaggg cttcaccatg 962941 cgtttttgcc gcttcttcat gttctgcctc gaattgctcg tttaccagcg tgttccccga 963001 aggatcaaat acggtaagga aataatcagc catcaggttt ctcctccatt ttaaggttta 963061 tcagtctttc ttcatttata ttctaaaaag gaaatcaaaa tcctttatta tgctttatcc 963121 aaaattagta tataatgggt cagggaagga ggagattcag tgcttacaat tgatcacgta 963181 acgaagacat ttggagatta taaagccgtt gacggattgg acttagatat tccggaacag 963241 caaatgttcg gtctattagg cgcaaacgga gcgggaaaaa caacaacgtt tcgcatgatc 963301 ctaggattat taagcattac ggagggctca atcagctgga agggccgtcc tgtgaattat 963361 catatcagca acaaaatcgg ttatttgccg gaagagcggg gcctttatcc gaaaatgaag 963421 gtaagggatc agctcgtcta tcttgccaga ttaaaaggga tggagaagcg agaggctgta 963481 aaagagctcg ggacatggct tgaacgcttc aatattacag attacgagaa taagaaggtg 963541 gaagagcttt cgaaggggaa tcagcagaaa atccaattca tttcggcagt tttgcataag 963601 ccggagctcc tgattcttga tgaaccattc agcggcttgg accctgtcaa tgttgagctg 963661 ctaaaagagg ccgtgatctc gctgaaaaac agcggtgttt ctattttatt ttcaagccat 963721 cggatggaac atgtggagga gctttgtgag aacctttgca tattgcagaa aggaaaaccg 963781 gttgtacaag gcaagctgaa ggagatcaag cgttctttcg gtaaaaagaa tgttaccatt 963841 cactccgatg acgatctgcg ctttttgcag tcccatgaag gcattcttca atggaaggaa 963901 acggcagacg gcgtcaagct gcagattgcc aatgaagaca tttctcaaga gatttttgcg 963961 atgctccaag gaaaagggtt tatcagaaag tttgagcttg aagagccgtc actgcatgat 964021 atttttatag aaaaggtggg ggccgtctat gaataaattt tggatcatgc tttctcatac 964081 atacaaaaat aagattatgg caaaatcctt tattatttcg actgtcatca cggtgctgct 964141 tgttttagtt gtaacgaatc tggagtcgat catttctttg tttcaaggtg acgatgcgaa 964201 agaaaaaatc gccgttgttg atgaaacaaa cgaattatat ccggtttttt ctaagcagct 964261 gaaagcggtg gatacagacg gcgatcttga tgtgaagctg tcgaagcaat cggaggatga 964321 ggtcacaaag caagtcaaag atgaatcact cgatggcatg ctcatcatca aacgagatga 964381 aaaagggacc atttcaggaa catataaagc gttaacgatt tctgatgaaa gcacgtatca 964441 aacactgcag caggcgctga cgcaaaccaa aacagctgtc ggaacagcgg agctcggcgt 964501 gtcgcaggaa acgattagca gcctttatgc gcctgttact gtggggcaga aggcgctgaa 964561 agaaggggca aagtctgagg aagagcttgg ccagacggta gggcttgttt acattatgct 964621 gttcgtcatt tatttctcgg tgattatgta tgccagcatg atagcgatgg aggtcgcaac 964681 cgaaaaatct tcgcgagtta tggaaatcct gatctcaagt atgccgccga tccagcaaat 964741 gtttgcaaag ctgcttggta tcgggcttgt cgggatcaca cagcttgcta ttattatagg 964801 agccggctct ctgtcgctta agctgaacca aaagagcgaa acggcttcat ctgtcggcgg 964861 attccttaat ttgaccgacg tatctgcaac cactgtcatc tatgctgtca ttttcttttt 964921 gctcggatac tttttgtacg cgacacttgc cgcgtttctc ggcagtgtcg tcagcagaat 964981 agaggacgtg cagcaaacga tcacgccgat gacgcttttg gttgtcgccg gttttatgat 965041 cgcgatgttc ggtttgaatg cgcctgacgc aggatttatt acggtaactt cgtttattcc 965101 gttctttacg ccaatgatta tgttcctgcg cgtcggcatg cttgatattc cgttctggca 965161 ggcggctgtc ggaatcggaa tcacactgct caccattgtc atactggccg ttatcggcgc 965221 cagaatttat aaaggcggtg tattaattta cggcaattca agcgcgttca aagcgatcaa 965281 acaagcgcta cgtttagcga aaaactgatt ggaaaacagc ctggggattc tcaggctgtt 965341 tctttattga cagaacgtgc attcgcaaga attcggtgct aaaataaggg tacttcatcc 965401 tggaaaggag cagaatgttg actgatctaa cctttattca tgcggcagat cttcatcttg 965461 acagcccgtt ttacgggata tcgcatctgc cggagccgat ttttgcccgg attaaagaaa 965521 gcacgtttgc aagcgtgaga catatgatag acgccgcagt gagagagcac gttgatttca 965581 ttttgcttgc gggagatctg tttgatgaag ccaatcgaag cttaaaggct cagctctttt 965641 tgaaaaaaca gtttgaaaga ctcagagagt gcggaatttc ggtatacgtc atctttggga 965701 atcacgatca tcttggcggg gagtggacgc cgattgaatg gcctgagaat gtccatattt 965761 tttcgtccgc tgttccagaa gaaaaatcgt tttttaaaga aggcaggcgc atagcaagca 965821 tttacggctt cagctatcaa gccagagcat tgatggaaaa ccaagccgcc cgctatcgga 965881 gatcaactga cgcaccgttt catatcggca tgctccacgg cacgctgtca ggatctgaag 965941 gacacgatcc gtattgcccg tttacacatg acgacctcgt gaaaagcggg atggattatt 966001 gggcgcttgg ccatatacat aaacgccagg ttctatctgc cgagcatccg gcagtcattt 966061 acccgggaaa cacgcaagca cgccatataa aggagacggg agataaaggc tattatctcg 966121 ttcatgtgac aaacggagat atatcttatg aatttcagag agcgcatgat gtcctgtggg 966181 aaaaagcggc ggttgatgtg acggaggcaa agaatatgac agccctcttc caaatggtgg 966241 aggacacgtt ttcgaagctg cggaaaaagg ggagccctgt ttgtgtaagg cttgttttac 966301 aagggacggc gccggaatgg ctgctggagg cgccaaaagg caccttggat gagtttcttg 966361 aagctcttca ggaacaagaa gcggaagagg aacgtttcgt ttggcctctt agattggacg 966421 atgagacaga aaacgaagca aacctaacaa accttgatcc tttttttggc ggtttatttg 966481 aagacattga tcgcagcgat ctgtcagacg tgctggaagg gcttgagcgg catccagtgt 966541 atagaaggca cgcggaccgg tttagccaag aggaggtaaa ggaaataaaa gagcaggcac 966601 agataatatt gaaaagacag cttaaggtgc ttgatacatg aggcggtgac agctttgcga 966661 attatatctt tacatatcta ccaatacgga aaattttcca atcggacctt tgacttttcc 966721 gcctctcctg tccaagtcat ctacggatta aatgaggcag gaaaaacgac gatgatgtca 966781 ttcattgaaa gcatgctgtt cggttttccg aaaacgaaaa agtatgaacc gaaaacaggc 966841 ggtgtctacg gcggtgttct tgaagctgaa catcctgagt atggggtgct gaagatcgaa 966901 cggacgaaag ggactgccga aaaactaagc gtgtacacag aaaagggcga agtaaagcag 966961 ggagatgttt taaagcagct gttccagggc acagacaggt cgttgtacaa agccatatat 967021 tcgttcgacg tattcgggct gcaggaaatt cacgccttta atcgggacaa gataggggaa 967081 tttttgctct tttccagctt gtttggtgct gaagccgtat caaagcttga ttcaaggctg 967141 acgaaggaaa gcgaaaggct ctataaacca aatgggcgaa accctcaatt gaatcaggag 967201 ctggaaacgc ttaagcagct ggcagttaag ctaaaacagg ctgaagcaga ggaagcgggc 967261 tatcatcagc ttctcgagga aaaacgaacg cttgaagccc gccttgcagc cgcggaaacc 967321 gaattgaaag agacggcggg acatatccga atgattgagg gagcgattga gcgaaagccg 967381 ctgctaaatg aaaaagcgac actcgaacag gtgattgcag aatttccgga acacgcagga 967441 caatttcctg ctgacggact gcatcagctg gaaaaatatg aatcccatct tcacccgaaa 967501 tcagcacagc ttgaggcgct tcgggtgaag atggcggagt tggacaaaca gaggcaaaag 967561 cttatccccg ataaagaact attggcgaaa gaaacgctga tacaagagct ttcggcagcg 967621 tttcatatgt accaatcctg gggagaacag ctggcagcca ttcaggcaca gctgcgccag 967681 acgtctgcgc agacagcggc agggctggaa cagctcaata aaacggatga aaatgagctc 967741 ctgaatatga acacctcata tgattatgaa tggcagcttc agcaagcggt gcagcaatat 967801 gtacaggcaa gagacagaaa acggcagctt gacgagacgt ttgaacttgc ccggcaagag 967861 ctggaagacg cggaaaaggc cgttcgtgcc gcttcgtccg cgattcttga aaacagccaa 967921 agaaaagata aagaagcagc tcttagagca tatgatgaaa cacaggggca gcaccaagag 967981 caagcgaagc tcagagaaca gctaacgttt tttgaaagac agcaggctaa acagaaaaag 968041 actgtcattg cagctggtat gttgttcatc gttctctttt ctctgctgca gcaatggatt 968101 cccgccataa gtttcggcgc tgcacttatt gtgtattggc ttgtttcagg aaagtcgtct 968161 tctcgaaaca gccgagagac aagacagccc atgacggata tttcaccagc agaagctgaa 968221 atgcttagag aagcgttatg ggaggatgac cgcaataagc agcaccttct cacacagcgt 968281 gcagcgctcc agcaaaaaga ggcggcgtat gaaagggtca tccagcagtt tgaacagtgg 968341 gaagccgaaa tggcgccgtc ctttacacag gttgagcgtt ttatgaatga gctcggattt 968401 aaggaagatc catcattttt gcttgatgca tacagcttaa tgaaggatgt taaaaaagaa 968461 gtgaagaaaa agcatgagct gaccatagaa gcaggcaggc tgaaaaagca ccggagaaca 968521 ttcgaagaac gcgtcagtat gcttcttccc gtgaatcaga gtcaggatat ctccatttcg 968581 gacgcccttc acacattgcg gaaaaacatt gaacgtgaaa aagaaattga gaagcaaaaa 968641 aaggaaattg aaacagatat tcattataca aaggaacaga tgcttgaact tgagcaagaa 968701 atacagtatt tccacgcaca gattgaacag ttatttgccg cggctgctgc aaaagacaga 968761 gatgcgtttt ttgccatagc cgccatcagc aggcaattga aggatacgga gaacaagctt 968821 catcacgtaa acgcacagct tcaaggcggg tacccggagg aacttgaact ggcggattcc 968881 aatacgcttt ctgaattgaa agataagcaa tttgttgaga atgaaagaaa agagcggctg 968941 actgaggaga tcgagcagct ccgcagccaa atcgcactgc tctcagtcaa acaggaacaa 969001 ttagaggctt cgggaatggt ctcagacctc aagcttcaaa ccgaaatgca aaaagaacgt 969061 gtgaaagaaa cggctaaaaa atgggcctcc atacaaatgg tcaaacaggt gatcagaaac 969121 aaattggagc ggcataaaaa aatcgagctt ccgcgccttc tggagacggc aggagaattt 969181 ttccgtcctc tgactgacgg aaactaccaa accatttatt tttccgaaac ggatgattcg 969241 atcatggtta tgcatcgcga tggcactgtc tatcatgcgg aagagctgtc acaagggacg 969301 tgtgaacagc tgtatacagc gatccgcttt gctttggccg ttacgcgcca gggtgagtca 969361 aagcttccgt tccagcttga cgacagtttt gttcattttg atcaggaaag gctgaaacgt 969421 gtattacatg ttctgtatga tttatctgaa ggcggtaggc agattttgta ttttacatgc 969481 catgagcacg taaaagatgc atttcatagc agccaaatca tccatttggt gtcataaaag 969541 aggttctata gctgaaaatc ggtatgtgat atactggtat tatgtaagat acggagggag 969601 ctttaataga atggctaaag ggattatgct acatgaggtt ggcgaacagg tggaccagta 969661 tctattgatt aaatcctcga cgaaagggat tgcaagcaat ggaaaaccgt ttctgacgct 969721 gatgctgcaa gaccagtcag gcgatattga agcgaagctg tgggatgcca agcaaagtga 969781 tgaagtgacc tatgcgccgc agacgattgt caaggtcgtc ggcgatgttc accattatcg 969841 cggacgcacc cagctgaagc taagaaatat cagaccggta agcgagcaag aaaacgtcaa 969901 tattgatgat tttttagaaa ccgcgccgat tccgaaaaat gaaatgatgg ataccatcac 969961 tcaatatata tttgaaatga aaaatccgaa tatccagcga atcacaaggt ttttggttaa 970021 aaaacacgaa gctgagttta tggattatcc ggcggctacg aaaaaccacc atgagtttgt 970081 ctcaggtttg gcgtatcatg ttgtctctat gctgaacctg gcgaaagcaa tagcagattt 970141 atatccttct cttgatcgtg atctgcttta cgccggtgtt atcctgcatg atcttggaaa 970201 agtgaaggag ctgtccggcc ctgtttccac ttcatatacg gttgaaggca atttgctcgg 970261 ccatatttcc atcatggtga cagagctttc aaaagcggct gaggagcttc aaatcgattc 970321 tgaagaggtg ttaattcttc agcatttgat tttgagtcac cacggcaaag cagaatgggg 970381 cagcccgaaa ccgcctatgg tgaaagaagc ggaaattctt cactatatag acaatctgga 970441 tgcaaaaatg aatatgatgg acagagcgct tgagcgcgtg aagccgggcg agtatactga 970501 acgtgtattt gcactggaaa accgttcctt ttataaaccg acatttcata aataacttaa 970561 aaaggactga tgctgacata ttcagctcag tcctttttga tgcgtctttc ccgcacataa 970621 ctcgtctcat tcccgcatat ggttaagaat aaagaatcta tgcaaagggg gaggagcccg 970681 tgttattttt tccgtggtgg gtgtatcttt gtattgtagg catcattttc agcgcatata 970741 aacttgtggc ggcagccaaa gaggaagaaa aagtagacca ggcttttatt gaaaaagaag 970801 gacagattta tatggagagg atggaaaagg agcgagaacg ccgcagttct cagcagcatg 970861 aagaagaaaa tcaaaaccat tccatcgcat aaaaaaagct gtgcggctca atgagccgca 970921 cagctttttt tattatttag aattgcttga agatgaagaa gtgctgttgc ttgttgaaga 970981 tgtattaaat gtgtctttca gatctttatc ttttacttcg atgtcagcct tcttcatgac 971041 tttttgaaca gcttcctgaa cagctgcgtt gtcatttaat ttttgttcaa gcacttcaga 971101 tttcagttct tttttcatat catcatattt gccgcgttct tctgtctttt taatgatatg 971161 gtagccgtat tgcgttttga caggatcact gacttcacct gtttttaatt tgaatgcagc 971221 tttgctgaat gtttcgtcca tttggccttc ttttgcgaac cagccaagat ccccgccttt 971281 tgaagcagag ctgtctgttg agtattcttt cgcaaggtct tcaaacttct cgcctttttt 971341 cagctttttc tctacttctt cagctgtctt tttatcagca acaaggatgt ggcttgcacg 971401 gattttgcct tttaagcctt cccagtactc tttgatatcg gcgtctgtta ctttgatgtt 971461 atctttagcc gctttttgtg tcagcaattc atattttact tgttctttca ggtaatcttt 971521 gccatattgc ttttcgaggg cagtatattg atcgccaagc tgcgttttgt attctttcag 971581 cttgttgtca atttctttat ccgaaacttt atacttcttg tccaatactt tttcttgcac 971641 tagctgtgtc agtacgcttg cgccagctgt tttcttcatg tttgtgtaaa gctcgccttt 971701 tgtgacatcg cctgcgtctg tttttgcgat aacttctttg tcgccgctgc tgcaagcact 971761 gagagcgagg atgcttgtag cagtgatagc tgctattgcg attttcttca ttgttttcaa 971821 acactcctaa tcattccaaa ttaaattacc tatgcgtatc ataacatatt gtggctttct 971881 gtaaaaagat tttaaataaa gggcattcgt ctagtcaaac ttttgctgat gacatactta 971941 tatattgatc aagaaaagga ggtatgtaac atgagcggag gatactctaa cggattcgcg 972001 ttgctcgtag tactgttcat tttgcttatc atcgtaggtg cagcttacat ctactaagca 972061 gcccgaggat cgcttgcaac ataagcgatc ctttattttc actagcgcct aatcgtttca 972121 aacatgaatt gcataacatg taattggtaa ataaagctta ttacaggagg tgctatttaa 972181 gatgggtgaa gtatttgcag gcggattcgc tttattggtt gtgttattta ttttattgat 972241 tatcatcggc gcttcttggc tgtactaatc aacataaaaa agcatagctg cttaatcagc 972301 agctatgctt tctttcgtat ttacactgta aaggagatct ccacaaacga agagatcagt 972361 aaaattaata tagatacatt aataaatcgg aataccttat cttgccgctc ttcaggaatc 972421 tctctgacaa ggcataatgt attggtgagc ctgtttatga aatataaaat aaacacggca 972481 gccacgataa aatagaataa aatgatggga gattccccct ctctctgaac tgtcccatat 972541 tacattacca aatatttatt aaaaaagata gaatgcaaat tgaaaaatcg ccaccagcac 972601 cagggtttga ctacttttca acaagaatat ccaagccgtc agcttcctga tcaataaaag 972661 cggttttcgg tgcttttatc agcttgagag ccagcaggaa atcaggcaga cagtagccgg 972721 cgtgaatgcc cgagatcatg caaaaataat gagcgtgatt cggaaatgcc agtgctgcgt 972781 aaaacaatac cggtgtaatc agcaagaacg ggctgacgag tgaaatcagc attgttgttt 972841 ttggtatacg tttccatgtg cgcatgcgca atatgtaaaa ctttttttct atttttcttt 972901 ttttgcagat gattggcagg acatggatga ctttatgtac aaataaaata acgacgagca 972961 aaccgccgaa taaagataca tattcatcgc ttaagcttgt gccaggccgc agcagctcaa 973021 aagctaaaaa ggtagatata aaaaccaaaa tcataaaaca tacagcagtt aatattatgc 973081 gaacggcgcc ataatccttc atgagattta tggtcttcca gcaattcatc aaagtcatcc 973141 ttccatacat cttgaataga atctcaaaat aatttactcc tcccaagaga aaaaatcaat 973201 gcttttttaa gaaaaaatat catccggcag gtattttttt gaaacaagca aacaaactgc 973261 gaaatatggg gttagaactt tcttctcagt gaattatcag ctaaaataag attaaagata 973321 gaaagaagtg gtgtggatgg attcgatgga tcatcgcatt gagcgattag aatattacat 973381 acaattatta gtgaaaacag tagatatgga caggtacccc ttctatgcgc ttctcattga 973441 taaagggctg agcaaggaag aaggggaagc ggttatgagg atatgcgacg aattgtcgga 973501 agagctggca acacaaaaag cgcaaggatt tgtaaccttt gataagctcc ttgcgctttt 973561 tgccggacag ctgaatgaaa aattagatgt tcatgaaaca atttttgccc tgtatgagca 973621 ggggctttat caagagctga tggaagtctt tatcgacatc atgaagcatt ttgattaact 973681 gtttacaggt tcgagctctt cagccggttc atccgccgca ctgtcctttg cttttttctt 973741 caattttccg tttacgcttt caaagtcatt gtcaatattg gtgagtgacg tttcgaaaat 973801 ttccataaaa tcatcgccgt agatatggcg tatcatacac atcatttctg ccacttcagg 973861 aaattttccg aataaatgat ataaaggctg tgacccttta aaaacagcgt tgcgtgtcgg 973921 atcaaattcc tcaagcaagc tccagaatac ctcggtacct tcctcagtca attggacata 973981 tgtgttccgt ttatcattca gccgtttgga gaaccttaaa tatccccgtt cttccagctt 974041 ttttgaaaag ttgaatgcgg ttgatacgtg catgaccccg aatttcgcga tttcagaaat 974101 ggaagctcca ttcaattgat acgcaatcca taaaatatga tgctcattaa tattcaggtc 974161 atacggtttg agccattgct gccaatcctt ctcgatcgat ttccaaagag ccttgctaag 974221 ctgagccatt ttctgggtga aaaccagagc ttctttcaca tcatagggcg gttccactcg 974281 attcattacg tcacctgctt ctctttttct ttttctctat tatgccaata aaataaagat 974341 taataaagat gaaaatgtaa gaatttttta ataaattcac aaaccattgc gacgaaaggg 974401 tttttcggcc aaaaaaaata cgggtccaat tttggcccgc atttttttct tttgaatagg 974461 atattagttt tgtaaggttt tctccagctg tctgattttc tcttcgatat cggcaatttc 974521 tttttgcaga tcctgctggt gaggcttgat ctcttcctgc cattttttaa ttgatgtttg 974581 gagctcgccg cccacgtctt taataacatc cgtgctttct tttgccgctt tgatcagctg 974641 gtcttttaat gcaagcccgt ctgactttaa gcgtttgatt gtttcttcaa aagaatcata 974701 attggttttc attttttcac gcagctgctt tcctgaggaa ggtgcagtaa gaagaaccgc 974761 tgctcctccg atgatgccgc ctacgaatag tcctgttaat agagaacgtc cgctcgccat 974821 tacaatcacc ccgtcttttt cttcaaaata ggattcattc agcatttttc atttttgttg 974881 aaagcctgaa cttctataca tagcttgctt tattttagca tattttttaa gtgaaaagga 974941 gggagaaggt tgtctgtctt tttgattgta ttatcctgca tcacccttgc cttcgcttca 975001 ggcgctgttt actatatcaa acttctcagc caggctgctt cttatccgcc caagagggtt 975061 atccggcaga aagcgcttgt ttgttcaacc ggaaccgcct ttacactatg tcttatcttt 975121 ttcacaaaac tcctcgctta aaacatgctg acatgctgcg ggcgctctgt tcaaaaaaac 975181 ctctcccgga agcggaagag gttttgtgtg acaattattt agcagcttcc ataaagcttg 975241 aacgccttaa aatggtttgc acaatcggat aaataatgat cattgagatt gtattcagca 975301 cagcggccgg cagaacaaca gccgcgaaca atgcggcgaa accgcccggt aaaccgacga 975361 tcaataaagc tgacgataga aacacaattc ctgataagat ggtcccgatc actgtcagca 975421 cagcggctgc acctgttttc cggctctttc tgaacaagag aaacagggag aagaacagaa 975481 acgctgatac gggtttatca atgatgttag ggatctgtcc ggctggaaac gcggttgtaa 975541 gcgcggaaat gattccggtc acgatcccga tgacgagtac attttgcacc cgcgggaaca 975601 gcagaatgcc catgaacatc atgatcagca tcatatctgg tttcatgccg cctaaaaagg 975661 gcggaataat ggaatgaagc gctgcgccga ttgcggcaaa cagagccata atgactaact 975721 cttttgtttt cataactatg ctctcctctg ctaagctttt tgccctccaa taatatgctc 975781 atcatttatt gcgaaggctt tacagaatgt gttatgcaaa cagtatacca aacggacggt 975841 ttgcatagcc agacttttta ctcattttcc tgctggaatt tcttcatgaa cgcagctaat 975901 ttttcacagt cttcgagaga gaccgcgtta taaatagaag cgcggcagcc tcccaccgaa 975961 cggtgtccgc caaggccgat catcttcgca tcttttgctt tctgaacgaa tgttttcgtt 976021 aattcgtcat cccgaagcgt gaatgtgaca ttcatgcgtg agcggctgtc ttttctggca 976081 tgtcctttat agaagccgtt gctttcatca atacagctgt agagaacctg cgctttttgt 976141 tcattgcgct gttcaacagc ttccacaccg ccgttttcct tgagccattc cagaacgagg 976201 ctcagcatat aaatcgcaaa tgtcggcgga gtgttgtaga gtgaatccgc tttgacatgc 976261 gtggaatatt tcaagatttt tgggacgttc gcattttcat tttgcagcca gctttttttc 976321 atgatgacta cagtcacgcc ggaagggccg aggttctttt gggcgcctcc gtagatcaca 976381 tcaaatttgg acacatcgat ttttctgctt aaaatatcgc tggacatgtc ggctacgagc 976441 ggaattggag aattcggaaa ctcctgccac tgagtgccga aaattgtatt gttggatgtg 976501 atatgtaaat atgcgccgtc ttttacatcc gtaaggtcaa cctctggaat ataactgtaa 976561 ttgtctgttt cacttgtagc ggtgatagac gtgttcccga acagtttcgt ttctgccagt 976621 gctttttcag accaagcgcc ggtcatcaca aaatgtgcgg ttttttcagg tgttaaaaag 976681 ttcatcggaa gcattgagaa ttgaaggctt gccccgcctt gaagaaacaa gatatcgtaa 976741 tcttccggaa tgcccatcag ttcgattaag aggcttttcg ctttttggtg caccgcttca 976801 tactctttgc tgcggtggga aagctccata acagacatgc cggattcgtt aaaatcaata 976861 aattctttct gtgctttttg cagaacttcc agtggcagcg ctgcaggacc tgcgttaaaa 976921 ttcgttgtac gttccattat gatctctccc tgttttccac gttaatgtat aaaataatac 976981 aattatccta tcacaaaaat tcagtttttt gataaaaaat tagaattatc aaaagaaatt 977041 gacggatgtt tgcgaaatgt tcacaaaata aaataacctc atcttatgat gaggccaggc 977101 gttttgcgat agaggaagag atgttctgca gatcctccgg tttataatca tcagcatgcg 977161 ttttccaaac cgctccgaat ccatctcctt ttccgtagcg agggataata tgcatatggt 977221 agtggaacac agattgtcca gctttttcgc cgttattgtt cagcgtattt aagccgatcg 977281 gttcaaattc atcccggata gcgcgggcga tttttggaac agcatggaaa tattgttttg 977341 ctaattcatc tgtaaattca tatacattct caatatgtgt tttcggaatg acaagcgtat 977401 ggccttttgt cacttggctg atatcaagaa aggcaagtac atgttcatct tcatacacct 977461 tcgctgatgg aatgtcgccg gcaataattt tacaaaagat acaattctct gcacaatgca 977521 tgagggttcc tccttatgaa attgtttagt atgtatacat tcatcgtacc acagaaatgc 977581 agaaaataga aaacaggatg aacggcgagc gttcaccctg aatgcagagg aagagcttat 977641 atgaagaaaa tgtgttatgc ctttggtaag cacctcattt gtcaataaaa tgaagacttg 977701 tttaatgcct aacgattcct gcgataaaca cctcatttga caatttgctt catacatgaa 977761 gaattcatca attcagtgaa gagaaatggt ttgagcattg gacatgttta ttttctatcc 977821 aactgtttct aagacgtctt tgacaaacac ctcatttttc agttgatatg cttttcctct 977881 acaactttta tgatgtccag aaccctgtct ctttatgaca gcaaattcat catttgttaa 977941 aagggaattg tttcaaatca ggccttgttt ttggtactat gaagaaaaac actataaggg 978001 gagaaactat gtctctgcta tcggtaaaag acttgaccgg cggatataca aggaatccgg 978061 ttttaaaaaa cgtatcattc acccttgaac cgaatcaaat tgtcggctta atcgggctga 978121 atggtgctgg taaaagtaca acaatcagac acatcatcgg gctgatggac ccgcataaag 978181 gttcaatcga attaaacggt aaaacgtttg ctgaggatcc ggaaggctac cgttcacaat 978241 ttacctatat acctgaaaca cctgttttat acgaagaatt gacgctgatg gagcatcttg 978301 aactaacagc catggcatat ggactgtcaa aagaaacgat ggagaaaagg ctgcctccgc 978361 tactaaagga attccgaatg gaaaagaggc tgaagtggtt cccggcccat ttttctaaag 978421 gaatgaagca gaaggttatg attatgtgcg catttttggc agagcctgcg ctctacatta 978481 ttgatgagcc ttttctaggg cttgatccgc ttgccattaa cgcgctgctt gaacggatga 978541 atgaagcgaa aaaaggcggg gcgagcgtgc tgatgtcaac acacattttg gcaacggcag 978601 aacgctattg cgattcgttt attattttac ataacggcga ggtgcgggcg cgcggcacgc 978661 tgtcagagct cagagagcag tttggaatga aggacgcggc gctggacgat ttgtatcttg 978721 agcttacaaa ggaagacgct ggccatgaat aatatgcttg atatttggca gtcgcggctg 978781 caggagcata tcaaagaaac aagaacatac atgaaatata tgctcaacga tcacctcgtc 978841 attgttttga ttttttttct agcgggcgct gcaagctggt acagcaaatg gatacgggac 978901 attcccgctc actttccgtc cttttgggtg atggccgtgc tgttttcgct cgtattgaca 978961 agctcttatg tgcgaacgct tttgaaggag gctgaccttg ttttcttatt gcctcttgaa 979021 gcaaaaatgg agccttactt gaagcaggcg tttgtctaca gctatgtgtc tcagctgttt 979081 ccgctgattg cgctgagcat cgttgcgatg ccgctttatt tcgcagtcac tccgggagct 979141 tcgctcgtat cgtatgccgc ggtctttgtc caactgttgc tgctgaaagc gtggaatcag 979201 gtaatggaat ggcgaacgac tttccaaaac gaccgcagca tgaaacggat ggacgtcatc 979261 attcgctttg cggcgaatac actcgttctt tattttgttt tccaatctgt ttatatgtat 979321 gcgcttctcg tctatgtcat tatggctgtt ctttatctgt atatgtcttc cgcagcaaaa 979381 cggaaaacat ttaaatggga gagccatatt gagtccgaat tgagacgaaa gcagcgtttc 979441 tatcggattg ccaacctgtt tactgatgtg ccgcatttgc gaaagcaagc caaacgcaga 979501 gcttatctcg actttttgct gcggcttgtg ccgtttgaac agcgcaaaac atttgcctat 979561 atgttcaccc gcgccttttt gcgttcgagc gattatttgg gcattcttgt cagattaacg 979621 atcgttttcg cgctgatcat tatgtatgtc tcagccagcc cgctgattgc cgcggttttg 979681 actgtgtttg ccattttcat tacgggcatt cagcttctgc cgctcttcgg tcactttgac 979741 catctggcgc ttcaagagct gtaccctgtg caaaaagaaa caaagctgaa aagctatttc 979801 tctctattaa aaactgcact tagtattcaa gcgctgctga tgtctgttgc atctgcctat 979861 gcagccggct tgaccggttt tctgtacgcg ctgatcggtt ctgccgttct gatttttgtt 979921 gttttgcctg cttatatgac gaccaggctg aaaaagcacg gaaagctgtg aactgaaaag 979981 aggtaatcaa atgacagata atcagctgct gatgcaggaa gctttggaat ggaaaatgca 980041 ttttttgcga aaggattcca tgtttgaacg cttttcgaag cgtgtccaga cgaaggtgaa 980101 tgaacggatt cctgaaaaaa tccatacggt cgtcaccgag agtgtgaaaa aaatggtaga 980161 agcgacaatg gccggctcta atatcatcac ctataaaaag gatacaagtg cactgtcgct 980221 cagtgaaaaa aacgaattgg cgaaaaaaac gattgtttct tatcaaaaag tggcagctgc 980281 tgagggagtc ggcaccggag cgggcggcat ttttttaagc attgctgatt ttccgctgct 980341 gctttcaatt aagatgaagt gtttatttac cttgtcttcc atttacggct ttgatgtcaa 980401 ggatgcacaa gaaaggatat ttttgctgct cgtgtttcag cttgcgtttt cgagtgatga 980461 tggccgtaag tcgctttttt ctgtcatcga aaattgggag acggagaaaa agagcatcga 980521 ctggagagtg ttccagcagg aatatcgcga ttatatcgac gtcgtgaagc tttttcagct 980581 tttgccgggc gtaggagcgg cagtcggcgg aattgccaat tataagctgc ttgctcagct 980641 tggagaaacg gcaagacatg tttttcatct gaggatatta aaggaaacag ccggagaata 980701 aacactccgg ctgttttttt atagctgatg ataggtgatc gcagcgccgg caaggacctt 980761 ggccgctgtc agcatggctt tttcgttgat atcaaatttc ggatggtggt gggaatagac 980821 tcgctctggc tgttcgggag cggcgcctgt aaagaaaaaa gtgcccttca cgttttgtaa 980881 gtaataagca aaatcctcgc cgcccatttg tggttcaccg tcaatgacct gctgaacgcc 980941 ctcggtattc tttgcggtgc tcaccaagtg gttcgtttct gcaggatggt tcacaaccgc 981001 tggataaccc tgttcatagg tgtactcata ggacgcgccg tgcatgctgc atattccttt 981061 tacaaccgct tcaatttctt tctccagaat gtcccggaca ttttcatcaa aagaacgcgc 981121 tgtgccgatg agtactgctt ggtctgcgat gacattaaac ggattgtcgg cgatgaagga 981181 gcctgtcgaa atgacggcgg attgaatcgg attgactttg cggctgacaa tgtgctgcaa 981241 agaggaaacg atttgcgaac cgattaggac ggcgtcttta gtatcatgcg gatgagcgcc 981301 gtggccgccc tttccgaaga ctttaatcgt aaatcggtct gccgccgcca ttacggcgcc 981361 ggggcggcag agaatagttc cgagcggctc agttgcccaa agatgagtgc cgaatatcac 981421 atccgtgttt tcgagacatc cgtcatcaat cattggcttt gcgcctccag gataatattc 981481 ttctgcatgc tggtggatca tcacaaatgt tcccttcagt tcatgtctgt tttggtgaag 981541 gaccttggcc actgcgagaa gagctgcggt gtggccgtcg tggccgcatg catgcatgac 981601 accaggcact ttggaggcgt aagggacatc tttttcatct tgaatgggga gagcgtcaaa 981661 gtcggccctc aaagcgactg tagggccggg ttcgcttcct tctatatttg ctaaaacccc 981721 tctaccgcca acgtttgtgc ggattgggac tcctaacgat tcataatagg aagcaataaa 981781 tgcggcggtt ttttcttctt gaaatgagag ctcaggatac atatgaaaat ggcgcctgat 981841 ctcaaccatt tcttcaaaac agccgtcgag ctgtttgttt atctctttct gcagtgtgga 981901 tatggacaaa gccgcttccc ccttttctat gcttttccat gattgtatag aaaaagtctg 981961 aatatttcaa ctcatgctgt tttaaagcat catcacagct gcgagggttg tcaccaaaag 982021 gccaatcgcg acgggaatga agttttttct ggcaagctca aaaggatcaa ctttgcaaat 982081 ggccgcggcg ggaatcaaag cccatgggac cagtgttcct ccgcccaccc agatggcaga 982141 gatttgtccg agcgcggtca gaatagcggg atcggcatgg agagcggacg aaaagagctt 982201 tgcgatggag ccggcgagag aaatgccaga aaatcctgag ccgtcaaggc ctgttatggc 982261 tccagcggca gttaatgcag tggcggcaag ctcctttgac ataggcatca tatgggataa 982321 agcaatgcca agatcgttga caatgccgtg ggaaccttta gggagtgaag tgcccagtat 982381 gctttcatag cctgagtcgc caagataaaa gaaagcggca atcgggatga cggggccgaa 982441 aaccttaaaa ccgaacttaa atccgtcaat aaaatagccg gtgatttttt caagcccttt 982501 atgcttatac acgaaaaaat gaacggtaaa gaggatacaa attgcagacc cgccaattaa 982561 cgcggttgca tcatttcctt gtaggttaaa caagagcatg caggcgatat ctgcaagaaa 982621 ggcaagcgga atcaaaaaag ccagtatgga ccgcaggcgt tttggcaagt acagcgagtt 982681 gtcttgttcg ccggaaagaa cgggggaaaa agaagtggga tgctcctgtt ttttgcgttc 982741 gcgctgaatc atgataaagg cagcagttgt tgttgtcaca cccataatca gcacaagcgg 982801 aatactggcc gagacgacat caccgactgg aatgcctgct gcatccgcag tcagctttgg 982861 cgccgcctga atgacaaagt ctcctgacag ggcaaaaccg tgtccgaata agttcatggc 982921 catggccgcg gcaagaggcg tcaaaccggc acgtgcggct gcggggagca ggacggcgcc 982981 gatcaaagcg acacccggag aaggccagaa gaatagagaa atggcgaaca tcaggcctcc 983041 aatcagccaa taggcagtca caggccctct cacaaggctt gcaaagggag aaatcatcgc 983101 ttcatttatc cctgtttttg ttaacaaatc actcattgaa acgataaagc aaatgatgaa 983161 aatcgtgggc agcagttcgc cggccgcata gataaagctg tggaataaac tgctgacaga 983221 agctgaaagt gaatggctgg cccatagcga tatgataaaa atgccgaata gagaaataaa 983281 tgtcgtgtct tttctcagca gcataaatag gataattgca ccgataaaaa acacatacag 983341 aacatggaca ggcaaaatcc cgacttccat catcgatcac tccttccgct tacagattat 983401 tcataggcgg gcggaaggtg ccgggacaga ggggagggtt atgatggaag atgaacattg 983461 atctgtttca gctgctcaat cagatgatgc cttaatcctc tattcgcttt ttgcagatgt 983521 tttgggaagc attcaggaga aaaaatgacg cacccttcag caagccagtt ttttctatag 983581 gcgatgatgc tttccgatgg ctctatatga gttatcctcg tgctgcatct cgtactcatc 983641 aaatccgaac tgaaaaccgc agcacgggca gatttcatga gaatgattgc cttcatgatc 983701 atatggcggt tcagccaatc cttaaacccg cagactgggc aagtatgctt cattttgctt 983761 tcctcccaat aaaataagct gccggacatg ccggcagcta ttcgacagcg aaatatgtgg 983821 tgacatagga aggccgggag aagatcgacg ttgtgtcaat tccggcagat gtatcgcgtt 983881 ttttgtgggc ttctttgtaa gaaccggact gctgccagtc ttgaaaggcg ctttccgttt 983941 cccacaaggt cagaatgaca taggtgtcac tgtcaagcgg acggagcact cgaattgctt 984001 caaagccagg ctcgttttcg acttttcccg ctctgttttt aaatctgttt tcaaacagcg 984061 gacgcccttc ctgagtaacg gcaatattgt tcaatactgc aaaaccggga tgtttgatct 984121 ctccgacttg gtcaatgact tcataagcgt gtggtgcctg gaaaacggta tctccgtttg 984181 tttcatgaat taaaatggcg ttttcctgcc cctgcatcaa aaggatattt tctgagggat 984241 gcttctgtac gatcgttttt aaaaaatcgg ctgtcccata tgtaatataa accttcatat 984301 cagccacctc ctgcttgcta gtatatcaaa acaatggtat aagtttctat tggcgagtgc 984361 ttcgaacata attccaaaca atttttccca tactaccttt agaaaggcga ggtgagttca 984421 tgtttaagat aaagaaaaag aaacttttta tacctatcat tattttagtg ttaactgctt 984481 ttctcgcttt aataggatat atttcaatta tttttctcgg ccattatgtc atagatgaaa 984541 aaaagcttat tcttcatgct tcttcaaaaa ttgttgatca aaacggagat gaggttgcaa 984601 gcctgtatac agaaaatcgc gagccggtct cgatcaatga gattcctaag caggtcagag 984661 aagcgtttat cgctgttgag gataaaaggt tctatgagca tcacggcatt gatgcaaaat 984721 ccgtcggaag ggcagtgtac cgcgatatat tagcaggcgg aaaggtggaa ggcggaagca 984781 cgatcaccca gcagcttgcc aaaaatattt ttctgacaca tgacaaaaca tttctaagaa 984841 aaacaaaaga agtgatcatt gcgattaatc ttgaacggga ttacagcaag gacaagctgc 984901 ttgaaatgta tttaaaccag ctttacttcg gacacggggt ttacggcata caagcggcgt 984961 cccactatta ttttaataaa gaagtaaaag atttgactgt atctgaaggc gctgttttgg 985021 ccgctattcc gaaggcgcct tctacgtact ctccaatttt gcaccctgat aaaaataagg 985081 agcggcgtga tacaattcta ggtatgatga atgaccaagg ctatatcagt gcgaaagagg 985141 ctgtcaccgc acagggccgg acgcttggac tgcatgtgaa gaaacagtcg gaaacacctt 985201 ggtttgacag ctacattgac cttgtgatca aagaggcgga agacaagtat tccatttccg 985261 gagagcagct tcttcaaggc ggatacacga tcaaggtgcc gctcgattcg aagctgcaga 985321 agacggctta ccaggtgatg aaagagggaa gctattatcc cggaacagat cagaatgccg 985381 agggaagcgc ggtctttatt aataacaaga caggcggtgt agaagcggcc atcggcggaa 985441 gggattacac atccaaagga tataaccgtg tcacagctgt ccgccagccg ggttccacat 985501 ttaagccgct tgctgtatac ggaccggcga tgcaggaaaa gaaatttaag ccatattctc 985561 tattgaagga tgagttgcag tcctacggag attatacgcc gaaaaactac gacagccggt 985621 atgagggcga agtcactatg tctgacgcca ttacgtacag caaaaacgcg ccggctgtct 985681 ggacgctgaa tgagatcggc gtcgaaacag ggaaatctta tttgaaagca aacggcattg 985741 atatccctga tgaaggcctt gctcttgctc taggcggctt ggaaaaaggc gtttcaccgc 985801 tccagcttgc cggcgcgttt catacatttg ccgcgaatgg aacgtatact gaacccttct 985861 ttatctcgag cataatagat gaagacggag aaacaatagc cgatcataaa gaagaaggaa 985921 agcgggtatt cagcaagcag acgtcttgga atatgacgag aatgctgcag caggtagtca 985981 aaaagggaac ggccacgtcc ggcacctatc acggcgacct ggcgggaaaa acaggttcaa 986041 catcttatac aggcgtctcc ggcgcgacaa aggacgcctg gtttgcaggc tatacgccga 986101 aaataaccgg ggcagtctgg atgggctatg acaaaacgga tcaaaaccat tatttgaaag 986161 ccgggagctc atacccgacg cggctgttta aggatatttt gacacaggca ggagaaaccg 986221 gtcatgtgtt cacaaagcct aaaaacgtta aagaactgga aagcccgatt gagctgaagc 986281 cggtcaaaac actcacagcc gattacacat ttaaagcagc ggggctcttt actattgaat 986341 taaagtggga cgctcaagag gatgatcggg ccgtatacag aatttatgta aacaaggacg 986401 gcgaggagac gcttcttgat tcggttgaag ggaagggaag ctatgaaatt ccttatgcca 986461 acttattttc gggcgcgtct tataaaattg tgccttataa tacacagaca aaaagagaag 986521 gggaaggaac cgattacgtt cagccaaaat tgttttcctc ttaatggaat tcggcgattt 986581 tttgaacttt gagctacatt tctataccat ttgcctaaaa caaggtatag tgtaataagt 986641 caagaaatac gaacgtatgg ttgccgtatg aaaggtggaa atcagatgag taaacgagaa 986701 acgtttaacg agacgttttt aaaagctgcg cggggagaaa aagcggatca cacgcctgtg 986761 tggtatatga ggcaagcagg gcgctcacag ccggaatacc gcaagctgaa ggaaaagtac 986821 ggattgtttg agatcacaca tcagcccgaa ctttgtgcgt atgtcacaag actgccggtt 986881 gagcaatacg gagtcgatgc tgcaatcctt tataaagata tcatgacgcc gctgccgtca 986941 atcggtgtgg atgttgaaat caaaaacggg atcggtcctg tgattgatca gccaatccgg 987001 tctctggcgg acattgaaaa actcggccag attgatccgg aacaggacgt gccgtacgtg 987061 cttgagacga ttaaactgct tgtcaatgag cagctgaacg tcccgctcat cggtttctca 987121 ggtgcgcctt ttacgcttgc aagctatatg atcgaaggcg gcccgtcgaa aaactacaat 987181 aaaacaaaag ccttcatgta cagcatgcca gatgcatgga atctgctgat gtccaagctt 987241 gccgacatga tcatcgtgta cgtgaaagcg cagattgagg caggcgcaaa agcgattcaa 987301 atctttgatt cgtgggtcgg cgcattgaat caggcagatt acagaacata catcaaaccc 987361 gtgatgaacc ggatcttttc agagctcgca aaggagaatg tgccgctgat catgtttggc 987421 gttggcgcaa gccatcttgc aggtgattgg catgaccttc ctctcgatgt tgtcgggctt 987481 gactggagac tcggcattga tgaagccaga tcaaaaggaa ttactaaaac agtgcagggc 987541 aacctggacc cgtccatttt gcttgcgcca tgggaagtca ttgagcagaa aacgaaggaa 987601 atacttgatc agggtatgga gtcagacggc ttcattttca atcttggcca tggggtattt 987661 cctgatgtca gtcccgaggt tttgaaaaaa ctgacagcat ttgtccatga atattcacaa 987721 aacaaaaaaa tgggtcaata ttcctaagca tatcttttgg tatcttaatg atatcctgtc 987781 aaaatgtttg tatcagatca ttaaagaggg tgtaaacagt gagtagaaag aaaatggggc 987841 ttctcgtgat ggcgtacggc acgccttata aggaagaaga tattgaacgt tattatacac 987901 atatcagaag aggcagaaag cctgaacctg aaatgcttca agatttgaaa gacagatacg 987961 aagcgattgg cggcatttca ccgcttgccc aaatcacaga acagcaggcg cataatctgg 988021 aacagcactt gaatgaaatt caggatgaga ttacgtttaa agcgtatatc ggactgaagc 988081 atatcgagcc gtttattgaa gacgccgtag cagagatgca taaggatggc attacagaag 988141 cagtcagcat cgtgctggcg ccgcatttct ccacgttcag cgttcagtcc tacaacaaac 988201 gcgccaaaga agaggctgaa aaactcggcg gcttaacgat tacgtcagtt gaaagctggt 988261 acgatgaacc gaagttcgtg acatattggg ttgaccgagt gaaggaaaca tatgcgtcaa 988321 tgcctgagga tgaaagagaa aacgcaatgc tcatcgtatc cgcacacagc ctgccggaaa 988381 aaatcaaaga atttggagac ccgtacccgg accagcttca tgaatcggcg aaattaattg 988441 ctgaaggcgc aggcgtttcc gaatatgctg tcggctggca aagtgaaggg aacacgcctg 988501 atccttggct cggacccgat gttcaggatt taacacgtga tttattcgaa caaaaaggct 988561 atcaagcatt tgtatatgtt cctgttgggt ttgtcgcgga tcacttagaa gtgctttatg 988621 ataatgatta tgaatgcaaa gtggttactg acgatatcgg cgcaagctat taccggccgg 988681 aaatgccaaa tgccaagcct gaatttattg atgctttggc aacagtcgta ttaaaaaaat 988741 taggacgtta aagaaggcga tgaacatgag tgacggcaaa aaacatgtag tcatcatcgg 988801 cggcggcatt accggtttag ccgccgcctt ctatatggaa aaagaaatca aagaaaagaa 988861 tctgccgctt gagctgacac ttgttgaggc aagtccgaga gtcggcggga aaatccagac 988921 tgtcaagaaa gacggctata tcatcgaaag agggccagac tcatttctgg aacgaaagaa 988981 aagcgccccg cagcttgtta aagacttagg tcttgagcat ttgcttgtca acaatgcgac 989041 cgggcaatcc tatgtgcttg taaaccgcac cctgcatcca atgccgaagg gcgctgtaat 989101 ggggataccg acaaaaattg cgccgtttgt ttctacgggt ctgttttcct tgtccgggaa 989161 ggcgagagct gctatggatt tcatcctgcc tgcaagcaaa acaaaggatg atcagtcatt 989221 gggagaattc ttccgcagac gtgtcggaga tgaagtggtc gagaacttaa tcgagccgct 989281 actatcaggg atctacgcag gcgacattga caagctcagc ctgatgtcga catttccgca 989341 attttatcag acggaacaaa agcatagaag cctgattctc ggcatgaaaa aaacaaggcc 989401 tcaaggctca ggccagcagc tgacggcaaa aaaacaaggg cagttccaaa ctctgtcaac 989461 cggtttgcag acccttgtag aagagatcga aaagcagtta aagctgacga aggtgtataa 989521 aggcacaaaa gtgaccaaac ttagccatag cggctcttgc tattcgctcg aactggataa 989581 cggcgtcaca cttgatgctg attcagtaat tgtgactgct ccgcataaag cggctgcggg 989641 aatgctttct gagcttcctg ccatttctca tttgaaaaat atgcactcca catccgtggc 989701 aaacgtcgct ttaggtttcc ctgaaggctc cgtccaaatg gagcatgagg gcacgggttt 989761 tgtcatttca agaaacagtg actttgcgat cacagcctgt acgtggacga ataaaaaatg 989821 gccgcacgca gcgccggaag gcaaaacgct gcttcgggca tatgtcggaa aagccggaga 989881 cgaatccatt gtcgatctat cagataatga cattatcaac attgtgttag aagacttaaa 989941 gaaagtcatg aacataaacg gcgagccgga aatgacatgt gtaacccgat ggcatgaaag 990001 catgccgcag taccatgtcg gccataagca gcgtatcaag gagctgcgtg aagcacttgc 990061 atctgcgtat ccgggtgttt atatgacagg cgcttctttc gaaggtgtcg gcattcccga 990121 ctgcattgat caaggaaaag ctgccgtgtc tgacgcgctt acctatttat tcagctaaaa 990181 cctccgcttt atcgcggagg tttttttgat gtgcaatggc aatattgtgt aaaaaatgat 990241 tgaattgaac agcaggttat gatacatttg catatgtact taatgactaa aatgttcaaa 990301 cggtcagttt cgaggtgaat acaatgtcaa tagatcgaaa aaagctcatt ttggaggcgg 990361 ctacaaagtc tttcacgcag ttcgggtata aagcgacgac aatggatctt gtcgcaaaac 990421 ttgcgaacgt ggggaaggga accatttata cttttttcaa aaacaaagaa gagctgtttg 990481 acgagatttt cactacttta ttaaaggaaa tgaagcaaaa agcggatgaa gcgatggagc 990541 cgagccttcc gttccatgaa aatgtgcaca gagcgctgtt tgccattctg gagttcagga 990601 aaacacatca gctgacgatt aaaattttcc aagagaatgc cgagattggt acaatggcag 990661 ttcaggaagt gatccagaaa atggagcgat ccatcctgtc ttatatcaaa agcaagattg 990721 aagacgggat caaaagcggc gcaatcaagc cgtgcgaccc tgagctgaca gcctttgtga 990781 tgctgaagct ttatatcgcg ctcatttttg actgggaaaa acaacacccc ccgcttgata 990841 aagagacaat tgcgggactg cttgaattgt atgttgtcaa aggattgtca gcgaactaga 990901 taatcctttc tctttgcaag aaaatgacca ttttttatga tgagtcagtt ttagaatgga 990961 ggcatcagga tgaacacaat acgaagtcag tggaaagaca tcgtaacaag taaaaaatta 991021 ttgattccca tcatcgccat tttgtttgtc ccgcttattt acagcggcgt attcttaaag 991081 gcttattggg acccgtacgg cacagttgac cagctgcctg tcgttgtcgt caaccaagac 991141 aagggagcaa cgtatgaagg agaaaaactt caaatcggtg atgatctggt caaagaatta 991201 aaggataata acaactttga ttggcatttt tccaatgatc tcgaccaatc gttaaaggac 991261 ttattgaatc aaaaatatta tttagttgtc gagattcctg aggatttttc taagaatgcc 991321 agcactgtat tagacaaaaa tccgaaaaaa ttggatctga aataccatac aaatgcaggt 991381 tctaactatg taggggcaac gatcggcgaa aaagcgattg ataaactgaa agcctctgtt 991441 tcaaaagaag tgaccgagca atatacgaaa gttatttttg ataactttaa agatatcgca 991501 aaaggtttga gcgacgcgag cagcggcgcg aaaaaaattg atgacggcac aaaggatgcg 991561 aaaaacggaa gcgcccagct gaaagaaaat ctggcgaagc tgaaggaaag caccgctacc 991621 atcagtgaca aaacagcgca gcttgcagat ggagcggctc aggtgacgag cggcatccaa 991681 tcacttgaca gctcgctcgg taaattccag gacagcagca accagattta tgataaatct 991741 agtcagcttg cagcaggatc aggcgagctg acaagcaaga tgaatgaact tcttgccgga 991801 cttcaaaatg tgcagaaggg tacgcctaat cttactaacg ggttggatca gctcaacagt 991861 aaagtccaag aaggttctga gaaagcggca aaagcggaaa agatcattaa tgcgctcgat 991921 ttaacgaagc ttgaaactgc tgtaaacaat ctggaaaagt cagaaactgc gatgaaggaa 991981 ttcaaaaaac agctgactga ctttgaaaac agtttgaaaa accgtgatca ggcatttaaa 992041 aatgtcatca attcgagtga cttcttaaca gcggagcaaa aaagccagct gattaattct 992101 gttgagaaaa agcttccgca agttgatgcg cctgattttg atcaaatatt aagccagcta 992161 cctacagctg atcagctgcc tgacatcgca acgataaaaa gctctcttga agacgtgaaa 992221 gcgcaggtgg cgcaggtgaa agccatgccg gaagctacat ctaagcttta taacggcgca 992281 aaaacaatcc aagatgcgat tgacagatta actgagggag ctgataagat atacaacggt 992341 tctcagaagc tgacagatgg ccaaactaaa ctgacagcgg gcatcggtga atataataag 992401 cagttcgcaa aagcaaaagc gggctcagag caattggtga caggaagcag ccaagtatcc 992461 ggcggattgt ttaagctgtt agacgggtct aaacaggtcc aaagcggatc atcaaaactt 992521 gcagacggat ctgcatcact tgatacaggt ttaggcaagc tattggacgg cacaggagag 992581 ctgtctagta agctgaagga tgcggctgac caaacaggag atatcgatgc tgatgatcaa 992641 acatacggca tgtttgcgga tccggttaaa accaaagatg atgccattca ttccgttcct 992701 aactatggaa cagggctgac accttatatc ctgtcaatgg gcttgtatgt cggcggcatc 992761 atgctgacgg ttgtcttccc gctgaaggaa gcgtcaggac gtccgagaaa cggttttgag 992821 tggttcttca gcaaattcaa tgtcatgatg cttgtaggaa tcattcaatc attgattgtg 992881 gcgacggttc ttctattggg aattggtctt gaggtagaga gcacgtggag attttacgtg 992941 tttacgatca ttacgagtct cgctttcctg gcgataattc aatttttggc tacaacgatg 993001 ggcaacccgg ggcgatttat cgcagtcatt attttagtgc tgcagctggg agcgagcgga 993061 ggaaccttcc cgctggaatt gcttccgaat ttctatcagg tcatccacgg cgcattgccg 993121 atgacctaca gcattaacgg attcagagca gtcatttcaa acggtgactt tggctacatg 993181 tggcagatgg ccggcgtctt aatcggcatt gccctcgtca tgattgcact aagcattact 993241 tactttacaa tgttaagccg gaaggaagaa acatcagaag aacagccggc ttcataaaga 993301 aaaagaactt gtttccttgg aaacaagttc tttttttgtt acatccccca tttaataagc 993361 aatcctgtat aggttaatcc gccgccaaac ccgaaaagca aaacgatttg atcttttttc 993421 agcttcccgg ctttcactgc gagatcgagc gccaaaacaa ttgaaaccga agacgtgttt 993481 ccgtagtgct caacactagt gagcgttttt tcaatcggga acggtgtttt ttcacaaatt 993541 gactcgatca tgcgcaagtt ggcgctgtga ggaacaaacc aatcgagatc atcggagctg 993601 agtcctgctt tatgtaaaag ccgttcaaat tcgccaggga cggttcttgc ggcccattta 993661 tatacctcgc gtccgttttg caccattttt ccggaaccga caagctgcac accgtttatt 993721 tcatttcgca gtccggcacg atacaaaata tcgccgccgt tcccgcttgt tccttgtaca 993781 gacgcaagaa atcccggcgt ctcttcatct cgttctacta acagcgcacc cgcggcatcg 993841 ccgaacagta cgcatgtcgt tcgatcggta taatcggtta cctttgataa cgtctctccg 993901 gcgatgacga gaattttttg atgaaggcca gatgtgatca atccatttgc caaatggagg 993961 ccgtatgtca gcccggcgca tgtcgcatta atatccagcg cgccggtgct ttcccagccg 994021 aaatattcct gtacgcggca tgccgtactc ggaaaggcgt aatcggatgt ggttgtggca 994081 acgaggatca tatcgacatc atcaagcgtt cctttataac ggctcttgag attcttcacc 994141 gcttctatgc ataaatcaga ggtaaattga tgttcatccg caatccggcg ttctctcatt 994201 cctgtgcgct gaacgatcca ttcatcagag gtatcaacga tcttttctaa atctgcattg 994261 gttaaacgtc tgctcggcgc ataggtgccg atagctgtaa tttttgcttt tgacatatga 994321 atcactcctt atggtcagat tataacacta gatattagta tctggtacta aaaagaaggt 994381 ttttttacaa aaaaagagaa gtgtagatag gaatctatga aaaagaaaaa ggaggctgaa 994441 aaatggtcag tcaagaagca gtagtctttt tggcattatc cggggctatt gcgtttctgt 994501 tgccaatcgg gctgattgta tggtttaagc gaaagtatgg tgcctcgctt aaagtgtttt 994561 ttattggcgc tctcacgttt tttgtcttcg ctcagctgct ggaaggcggc gttcatgttt 994621 atgtactgca agtgaatgaa atgacgaaag aagcgatgca gcatccatta tggtatggca 994681 tttacggctg cttgatggcc ggcatttttg aggagtgcgg aaggtatttg atgatgcgat 994741 tttttatgaa gcgccatcat acttgggcag atggtctggc tttcggggca ggccatggcg 994801 ggcttgaagc catcctgatt acaggcttgt cctctatctc acttattgta tacgcatttg 994861 caatcaatag cgggacgttt gaacagcttt tggtcaatgg cgacgtcaaa caggcgcttt 994921 tgccgataca ggagcagctg ctgcatactc cttcgtatga atggatgctg ggcggaatag 994981 aaagaatcag tgccattgcc gtccagattg gtctgtctct gcttgttttg tacgcggtta 995041 aaaaccgccg gccgctgttt ttgctgtatt ctattctttt acatgcactg tttaatgtcc 995101 cggcggtttt atatcaaaga ggaatcatag agcatgctgc agctgttgaa atcattgttg 995161 ctcttatagc ggctttatca gtttattgga ttgtaaaagc aaaaagggtg tttcaataaa 995221 aggtccaagc agcagcaatg cccgcttgga aaaatgtgaa tggaaatatt cattaagcat 995281 gggtcatcag aatatttctg attcagtctt tagcaatgac agcaagaatg tctgtgtttt 995341 ttacaagaga aacaatggtg tttctttttc ttcttctcgc aagggtcatg gcattctttc 995401 tttttcttgc aatggtcgtg gaaatcttta tcgaaccact cgtcaaagaa ccaaaaatca 995461 tcgaaccaat cgtgacaacg acatttctgt tcatgtgaat gacgacagca catagaaatc 995521 cctcctcttc ccatgctctc tacagcatat gagagattga taggaaaaga ttggacgggt 995581 ccctcgggaa aagagtatat tttaagtaga aaataaaagg aggaatgccc tatgacgtcc 995641 gtacgtaaaa cgatggagct cattaaagaa cttgtatcga tcccaagccc gacaggaaat 995701 acatatgagg tgatcaatta tattgaaagc cttttaaaag aatggaaggt agaaacggtt 995761 cggaaccaca agggcggctt aattgcaacg cttccaggac gcgacacatc ccggcatcgc 995821 atgctgacag cgcacgttga caccctcggc gctatggtga aggaaattaa agcggacggc 995881 cggctgaaaa tcgacttaat cggcgggttc cgctacaact cgattgaggg ggagtattgc 995941 caaattgaaa ccgcctcggg aaaaatgtac acaggcacaa tcttaatgca tcaaacgtct 996001 gtgcacgtat acaaagacgc gggaaaggct gagcggaatc aagagaatat ggagatccgc 996061 ctagatgaac ctgttcactg ccggaaagat acggaggagc ttggcattgg cgtcggagac 996121 tttgtgtcgt ttgatccacg tgtcgagatc acatcaagcg gatttattaa atcgcgccat 996181 ttggatgaca aagcaagcgt cgccttattg ctccgcttaa ttcatgaaat tcaaacagaa 996241 gacattgagc tgccgtatac aacccatttt cttatttcca ataatgaaga aatcggttac 996301 ggcgggaatt cgaatattcc tcctgaaaca gttgaatatt tggcggttga tatgggcgct 996361 atcggtgacg ggcaggcgac ggatgaatat tcagtatcaa tctgtgtgaa ggatgcgagc 996421 gggccgtatc attatcagct cagaaagcat ttagttcaat tagccgagaa gcatcatatt 996481 gactataagc ttgatatata tccgtactac gggtctgatg cgtcagcagc gatcaaatcc 996541 gggcatgata ttgtgcatgg cctcataggg ccgggaattg acgcttccca tgcatttgaa 996601 cgcacccata aatcatctct tcgccatacc gctaagcttc tgtattacta tgtacagtca 996661 ccaatggtat aagggggagg accaatgaag atttataagc tgaaaagcac attcggttgg 996721 gaaggtgatg acgggttggg agaacagctg attcagcaga tccttgccgg agaaaaaagc 996781 gccacgtgcg cgccgaaatc attgtattca aaagatgaat tgagggacgt ttatcaaaca 996841 gcgggtcagc ttgttaccgt ttatgataaa catgacaatc caagatgcaa tataaaagta 996901 acagatgtct ttgaaaccac ctttggtgcg cctgatatga ggttagtcaa aggagagggc 996961 aatggagacc gaattgagga gtttcaagag gatcatcgga tggcatgggc ggaactgatc 997021 aaaagcggtg aactggagct gaatgaggat actgttttga ttacagagtt gtttgtgctt 997081 gttaaagatt aaaaaagcct gcggggcaag aaccccgcag gcttttcatt aaccagaaat 997141 ggttgcgttt tgttctgttt tcgattggga cataacagtt tctgctttcg caggattaaa 997201 catgccttcc catttagaca tcacaacggc agcaagcgcg ttaccagtca ggttgacaac 997261 tgtacgtgcc atatccatga tgcggtctac gccggcaata aaggcaagtc cttcagccgg 997321 aacgccgatg gtgccaagcg ttgcaagcaa gacaacaaaa gaagtaccag gtacggcagc 997381 catccctttg gatgtcacca ttaagacgag cacaagcgta atttggtgcc aaatcgtcaa 997441 atcaatgcca tatacctgtg ctaaaaagag tgcggcaata gattgataga gaacggaacc 997501 gtctaagtta aacgtgtaac cgatcggaat gacaaatgaa acaatgcctt ttggacatcc 997561 gattttctcc attttttcca tgatacgcgg aagaaccgtt tcagagctgg acgtactgaa 997621 cgccagtaag atttcgtcct tcatgtaagc aaggaacttg aagatgctga tgccggcaat 997681 ttttgcgaca atcccgaaaa taacaattaa gaagaaagca agcgcgacat aaaccaatcc 997741 gacgagcttt ccgagagaga taagagaacc gagtccgaat ttagacacag tcactccgat 997801 aagagcgaaa acgccgaatg gcgccacttt catcacaagg tttacaacgt ggaacatggc 997861 atgggataca ccttcaaaaa aggctaatac aggcttgcct ctttcaccga tcgcggaaat 997921 acccaatgca aatagtactg taaagcagat gatggctaga agatcccctt cgaccaatga 997981 ctggaagaag tttgtcggca caatatggag gaacgtttcc gccactgatt tattactttg 998041 ttctttttca gtttcaacat attgactgat gtccgatttt tgagcttcgt gtatattaac 998101 tcctgtaccc ggatggaaga tgtttgcaag ggctagtccg agaataatgg caaaagtcgt 998161 gatgatctcg aagtacagaa tcgttctgaa gcctaattta ccgacttgct ttccatttcc 998221 tgcaccggct acaccgatga ttaagctgga gacaacaata ggaatcacta tcattttgat 998281 taagcgtaaa aagagatccc cgattggctg caggtaagta ggcaatgctg ggttgccata 998341 ccaaatgacg ccaacaatga cacctagaat aagtccaacg aatatttgtg tggctaatcc 998401 aaacttaatt cttttcatag attacctccc aaaaaacaaa gtatcaacat atatcatgaa 998461 tagacatata tttaatctca ctattagatc aaattataat agataagaaa tcaattcgtc 998521 tatagtaaat tatatttcga aaataaagaa tattcaatga cattatgata atcaccagaa 998581 ttatctaaaa acaggtgagc tttgacctaa cctgactatt atttcaaaat taagagatat 998641 gtgaaaaaat aagaaaatcc cacgcgtaag gcgcgggatt ttcgctcatt acaaatcgtt 998701 tacttttata cagtcattgc agatattacc ataacactca tgctgctctt ctatcttttt 998761 tccgcattcc gcacactttt tcgaaggcag gtttctaaaa aattctgtga ttttccccag 998821 cataaccaat ccctctttcc cctttgtagt gatttcattg taatataaca gattacaaaa 998881 atcaataact gttttgatac aatgtttaaa acatgctttt ttcaagaaaa atgggtatat 998941 tgaaggagga ccaatttttt tgaaaagata ggaggacatt atgaaagtta cagttatcgg 999001 atgctatggc ggttttccgg ccgcaaatga agcgacgtca ggctatttgt ttcagtcagg 999061 tgattactct ctgcttgttg attgcggcag tgccgtattg tctaagctgt tcggatatgt 999121 gccggcggaa aagctggatg cggtcgttct gtctcattat caccatgacc atatcgctga 999181 tatcggaccg ctgcaatttg ccaagcaagt cggttcgttt ctcggcaaag gagagcatac 999241 gcttccgatt tacggacatg atgctgatat agaacagttt caaaagctta catataaaac 999301 acatacaaaa gggatcgcct atcagccgga tcagccgctg actgccggtc cgtttacgat 999361 caccttttta aaaacgattc acccggtgac gtgctatgcc atgcggatta ctgacggcag 999421 ccacactgtc gtttatactg ctgattccag ctatcaggat tcatttatac cgttttcgaa 999481 agatgctgat ttattgatct cagaatgcaa tttttatgcc gatcaagacg gaacaagtgc 999541 aggccatatg aacagcctgg aagctgggcg cattgcaaaa gaagccggag cgggagaact 999601 gctgctgaca catttgccgc attttggcgt gcatgacaac cttcgcaaag aagcgaaaac 999661 cgtttttaac ggagaagtga atattgcgaa atcaggtttt gtgtgggaag gataaaggag 999721 gagcaccatg ttatttatag acaatcaaaa tatcaatgat ccgcggatca atcttgctat 999781 cgaggagtac tgtgtaaagc atttagaccc tgaacagcaa tatttgctct tttatgtgaa 999841 tcaaccgtct attatcattg ggaaaaacca aaatacaata gaagaaatca atacaaaata 999901 tgttgaggaa aacgggatta tcgtcgtccg ccgtttatca ggcgggggcg ctgtgtacca 999961 tgatctgggg aacttgaact tcagctttat taccaaggat gacggggaca gctttcataa 1000021 ctttaaaaaa ttcactgagc cagtgattca ggcgttacat cagcttgggg ttgaagccga 1000081 attaagcggc cggaacgaca ttgtagtaga tggccggaaa atatccggaa acgctcagtt 1000141 tgcaacgaaa ggccgtattt tcagccacgg caccctcatg tttgattcag ccattgatca 1000201 tgttgtatca gcattaaagg tgaaaaagga taaaattgaa tcaaaaggca tcaaatcgat 1000261 cagaagccga gtggcaaaca tcagtgagtt tctcgatgat aaaatgacca ccgaagaatt 1000321 ccgcagccat ttgcttcgcc atatttttaa cacaaacgac gttggaaacg tgccggagta 1000381 taagctgacg gaaaaagatt gggagaccat tcatcaaatt tcgaaagagc gctatcagaa 1000441 ttgggattgg aactacggcc gctcaccaaa atttaacctt aatcattcga agcgttatcc 1000501 ggttggatcg atcgatttgc acctggaagt caagaaaggc aaaatcgagg actgcaaaat 1000561 cttcggagat ttcttcggtg tcggtgatgt atctgaaatt gaaaacctgc tggtcggaaa 1000621 acaatacgaa cgcagcgtca tcgctgatgt gctcgaaggt gtgaatctca agcattactt 1000681 tgggaacatt acgaaagagg atttccttga tctgatttac taaggcaaaa cacatcgttt 1000741 gaaagagcgg ttgtgttttt gaaataatgg aggcaggagg gattcacatg aaagtgtttt 1000801 taatcggagc gaacggacaa atcgggcaaa gactcgtctc tttattccaa gataatcctg 1000861 atcattccat cagagcgatg gtcagaaaag aagaacagaa agcgtctctt gaagctgccg 1000921 gtgcagaagc tgtgcttgcg aatctggagg gcagcccgga agaaatcgcc gctgcggcaa 1000981 aaggttgtga cgcgatcatt ttcacagccg gttccggcgg cagcacaggc tatgataaaa 1001041 cgctgctggt ggatcttgat ggagcggcaa aagccattga agctgcggcc attgccggaa 1001101 tcaaacggtt tattatggtc agcgccctgc aagcccataa ccgtgaaaat tggaatgagg 1001161 cactcaagcc ttattatgtg gccaagcatt atgctgataa aattctggaa gcgagcggtt 1001221 taacctatac gattatccgt ccgggaggcc ttcgcaatga gcctggaacg ggaactgttt 1001281 cagcagcgaa ggatctggag cggggattta tttcccgtga tgacgttgca aaaacggtca 1001341 ttgcctcttt agatgagaag aatacggaaa atcgggcctt tgatctgaca gaaggagata 1001401 cgccgattgc cgaagcattg aagaaactat gacagtactg acactcaggg ctttttgctc 1001461 ttgagtgttt ttttctgttt ctctataatg gagaagaaag cttggcttca ataatgaatg 1001521 actattcatt cacttaaggg gtgggagaat gaatcttgtt tcaaaattgg aagaaacagc 1001581 atctgagaag cccgacagca tcgcatgcag gtttaaagat cacatgatga cgtatcaaga 1001641 gctgaatgaa tatattcagc gatttgcgga cggccttcag gaagccggta tggagaaagg 1001701 ggaccattta gctttgctgc ttggcaattc gcctgatttt atcatcgcgt tttttggcgc 1001761 tttaaaagct gggatcgtag ttgttcccat caatccgttg tacacgccga cagaaattgg 1001821 ttatatgctg acaaatggcg atgtaaaggc aatcgtgggc gttagccagc ttttgccgct 1001881 ttatgagagc atgcatgaat cgctgccaaa ggttgagctc gtcattttat gccagacggg 1001941 ggaggccgag ccggaagctg cggacccaga ggtcaggatg aaaatgacaa cgtttgcaaa 1002001 aatattgcgg ccgacatctg ccgctaaaca aaaccaagaa cctgtacctg atgataccgc 1002061 ggttatttta tatacgtcag gaacgactgg aaaaccgaaa ggcgcgatgc tgacacatca 1002121 gaatttgtac agcaatgcca acgatgtcgc aggctatttg ggaatggatg agagggacaa 1002181 tgtggtctgc gctcttccca tgtttcacgt gttttgttta accgtctgta tgaatgcacc 1002241 gctgatgagc ggcgcaactg tattgattga gcctcaattc agtccggcat ctgtttttaa 1002301 gcttgttaag cagcagcagg cgaccatttt tgccggtgtg cctacaatgt ataactactt 1002361 gtttcagcat gaaaacggaa agaaagatga tttttcttcg atccggctgt gcatttcggg 1002421 aggcgcgtcc atgccagtcg cgttgctgac ggcgtttgaa gaaaaattcg gtgttaccat 1002481 tttggaaggc tacgggctct cggaagcatc acccgtcacg tgctttaacc cgtttgacag 1002541 gggcagaaag ccgggctcca tcgggacaag tatcttacat gtcgaaaaca aggtcgtaga 1002601 tccgctcgga cgcgagctgc ccgctcacca ggtcggcgaa ttgatcgtga aaggccccaa 1002661 tgtgatgaag ggctattata aaatgccgat ggaaacagag catgcattaa aagacgggtg 1002721 gctttatacg ggggacttgg caagacggga tgaggacggc tatttttaca ttgttgaccg 1002781 gaaaaaagac atgatcattg taggaggata caatgtgtat ccgcgggagg tggaggaggt 1002841 gctgtacagc catccggacg tcaaggaggc ggttgtcatc ggcgtgccgg acccccaaag 1002901 cggggaagcg gtaaagggat atgtggtgcc gaaacgctct ggggtaacag aggaggacat 1002961 catgcagcac tgcgaaaagc atctggcaaa atacaagcgg cctgccgcca ttacgtttct 1003021 tgacgatatt ccgaaaaatg cgacggggaa aatgctcaga cgggcactga gagatatttt 1003081 gccccaataa aatgaaaaag cgaagcggtt agcttcgctt tttcattttc aatcctttgc 1003141 ttctttttta ataatattta gcagcgcctt tgtatcattt ttgcttaatt tgtagtatgt 1003201 gccatccttc aaaaaaacgg cttgctggct gccgtcaatc catagtctga atgagtcata 1003261 ccggtcttta tgaaacttga ttgtcccttc gtaatcaggg gctgatgttt tttctgtctt 1003321 cacctgtttt ccctgattca taatatccag catatctttg acgtgctgtc ttttttcaat 1003381 ctcgatatct tcctggccgc ttgaagacag tgtgatcaaa tccgcgtcta ccgattgata 1003441 cacatcgcct gatcggctgt aaagataaaa aaatgcgata aacacaagac cgattaccac 1003501 gatggctgcc actatttttt tcatttgcat cactccaaac attgttagtt ttcccagcga 1003561 tcggggtttc catgcttaaa agggtggaaa agtgcggaac acagcttggt tctaagaatt 1003621 tgaatttatg attacaatag aagtaacggg ttgatgtgag gagtgaggcg ttatgcgcaa 1003681 gtggattgcg gcagcaggac ttgcttacgt gctgtacggg ctgttttttt attggtattt 1003741 tttcctgtcg ggtgattccg caataccgga agccgtgaaa gggacgcagg ctgatccggc 1003801 ttctttcatg aagccgtctg agttggcagt ggccgagcag tattcgaatg tcaagaattt 1003861 tttatttttt atcggggtac cacttgattg gtttctgttt tttgttctgc ttgtcagcgg 1003921 tgtttcaaag aaaatcaaga aatggatcga agcggccgtg ccttttcggt ttttgcagac 1003981 cgttggtttt gtgtttgtgc tttcgctgat tacaacattg gtgacgctgc ctttagattg 1004041 gataggctat caagtatcgc ttgactataa catttccaca cagacaacgg ccagctgggc 1004101 taaggatcag gttatcagct tttggatcag ctttccaatc tttacgcttt gcgttctcgt 1004161 tttttattgg ctgatcaaaa ggcatgaaaa aaaatggtgg ttatacgcct ggctgttaac 1004221 agtgccgttt tcgctgtttc tgttttttat tcagccggtc attatcgatc ctttatacaa 1004281 tgatttttat ccgctgaaaa acaaagagct tgaaagcaaa attttagagc tggcagatga 1004341 agccaatatt ccggctgacc atgtatatga agtgaacatg tcagaaaaaa caaatgcgct 1004401 gaatgcctat gttacaggaa ttggggccaa taaacggatt gtattgtggg atacgacgct 1004461 gaacaaactt gacgattcag aaattctgtt tattatgggc cacgaaatgg gccattatgt 1004521 catgaagcac gtttacatcg gtctggctgg ctatttgctc gtgtcgctcg ccggatttta 1004581 tgtcattgat aagctttaca agcggacggt tcgcctaacc cgcagcatgt ttcatttaga 1004641 agggcggcat gatcttgcgg cacttccgct gttattgctt ttgttttctg ttttgagctt 1004701 tgcggttacg cctttttcta atgctgtctc gcgttatcag gagaataagg ctgaccagta 1004761 tgggatcgag ttgacagaga acagagaagc cgctgttaaa acgtttcagg atttggccgt 1004821 gacggggctg agccaggttg atcctccggt gcttgtgaag attttcagag gcagccatcc 1004881 gtcgatcatg gaacggattc aacatgcgga gaaagaagag aatgcgccgg aacatcagga 1004941 tgctgacaaa taaaaagaag caggtatgga ggaacctgct tctttttact attattgtgc 1005001 agctgcttgt acgttgatta acccttttcc atagtagaaa gagtttccaa gatatgttgc 1005061 agtgctttct aaacgatcac ggacttgcgc gtttgtccaa gtcgggtgct tagaaagaat 1005121 taacgctgct gctccggcaa cgtgaggagt cgccatggac gttccgttat aagcgccgta 1005181 agtgcctcca ggaagtgtgc tttggatgga cacgccagga gccatcacat caagctcaga 1005241 acctgcgctg gagaatgaag ctctttggtt gctgctgttt accgcaccta ctgcaatagt 1005301 agaaggatat tttgcagggt agccgactgt gcttgtgctt ccggatgaac cttcgtttcc 1005361 ggctgcggca gcaacgacga taccgctgga aacggctttg tcaacgactg ttttcagcgc 1005421 tgtagaacca gtaggtccgc caaggctcat gttgataaca tccatattgt tggaaatggc 1005481 ccactcaatg ccgttaataa tccagctata ttggccgctt cctgttgaat caagcacttt 1005541 tactgcatat aatgatgcgc ttggcgctac gcccagaaca ccgattgagt tattaagagc 1005601 ggcaatcgta ccggctacat gcgtaccgtg agaactgccg tcctggtatg ggtttgtttc 1005661 agaaggtacg aagcttgctc cgcctctgac gtttaagtca ggatgagaag agtcaattcc 1005721 gctgtcgata acagctactt ttacgttaga gcctgtgtag ccttgagagt gaagagccgg 1005781 cgctttaatt tgagaaatgc cataaggaac agattgcgca tattcatgtg caatatgatc 1005841 ttcttccaca tatgcaacgc tcggatcttt tttcaattct tttacagctt tttcatccaa 1005901 tgttgctgcg gccgcgttaa catacttaaa ttgcttttga acctttccgc ctttttcaga 1005961 aataacatcc tttttcttgg cggaactcat ggcactcatt gtctgtttaa atccgacaat 1006021 gtatttcttt tctgtactgc tttttccggc agcctgcgca gacatgttgc tgaacgccat 1006081 cgtaaagatt aacgttaacg caaacaacaa gctgatccac aattttttgc ttctcactct 1006141 ttaccctctc cttttaaaaa aattcagagt agacttactt aaaagactat tctgtgaatt 1006201 tattgtaata gatggaataa tattttagta gacccatttt tttgagatga ttttatctct 1006261 atttaggtat atcatctctc gctatttccg tagagactcg aaataactat tttcatacag 1006321 aaaagaacga aaatagacat gagtaaatgt tcattatgct gaaatgtcat gcttttttag 1006381 gttaaatgct cctgagtccc ggcaaattcc tgtcgaaaaa attcgttcaa atgacctgcg 1006441 tgtgcttccg tgagaacaat ggatattatc gtgatatttt ttcaaagcat gatgataaaa 1006501 gtattctgaa aaataaactt tacagaaaag ggatagaatg aaaaaattat tgagagggag 1006561 gaagaaataa gatgaacatt cgccaagcaa agacatcaga tgcggccgcc attgcgccgc 1006621 tgtttaacca atatcgggaa ttttatagac aggcatccga tttgcaaggg gcagaggctt 1006681 ttttgaaagc tcgtttggaa aatcacgagt ctgttatttt gatagcagaa gaaaatggag 1006741 aattcatagg ctttacccag ctctatccaa cgttttcttc tgtgtcaatg aaaaggatat 1006801 acatattaaa tgacttattt gtcgttcctc atgcgcgtac aaagggagcc ggcggccggc 1006861 tgctttctgc cgcaaaggat tatgcagggc aaaacggggc aaaatgttta acacttcaga 1006921 ctgagcacca caaccggaag gcaagaagct tgtatgagca aaacggctat gaagaggata 1006981 ccggatttgt ccattattgt ctcaatgtgc cggcgaagtg aaaatggcgg cttgatgatt 1007041 tggttttttg aacgttcttc ggttacgata taaatgaaaa ggagtgtgcc gaatgtcaac 1007101 gttatttcaa gccttgcagg cagaaaaaaa tgccgatgat gtttcagtcc atgtgaaaac 1007161 catatcaaca gaggatttgc cgaaggatgg tgtcctgatt aaagttgctt attccggcat 1007221 taattacaaa gatggtctgg ccggaaaagc aggaggcaat atcgtcagag agtatccgct 1007281 tattttaggc attgatgctg cgggtacggt cgtctcttcc aatgatccgc gttttgcgga 1007341 gggggatgag gtgatcgcga caagctatga gctcggtgtc tcacgtgatg gcggattaag 1007401 tgaatacgct tcggtgcctg gtgactggct ggtgcctttg ccacagaatc tttcgttaaa 1007461 agaagcgatg gtgtacggaa cggcgggatt tactgcggcg ttatcagtgc atcggcttga 1007521 acagaacggt ctgtctccgg aaaaaggcag cgtgctagtc acaggagcaa ccggcggtgt 1007581 cggcggaatt gcggtatcga tgctgaacaa gcggggttat gatgtggtgg caagtaccgg 1007641 aaaccgggag gcggctgatt atttgaaaca gcttggtgca agcgaagtaa tcagcaggga 1007701 agatgtctat gacggaacgc ttaaggcgct gtccaagcag caatggcagg gagcggttga 1007761 tccagtcggc ggaaaacagc ttgcctcgct tttaagcaaa attcaatacg gcggatctgt 1007821 cgcagtgagc ggcttaaccg gcggaggaga agttccggca accgtgtatc cttttattct 1007881 tcgcggagta agcctgctcg gaatcgattc agtatattgt ccgatggacg tcagagccgc 1007941 tgtttgggag cgcatgtctt ctgatctcaa gcctgatcag ctgctgacca tcgtggacag 1008001 ggaagtatca ttggaagaaa cgccgggtgc gttaaaagat attttgcaaa atcgcattca 1008061 aggaagagtg attgtgaagc tttaacagga tcagcttgca gagaatgtta tttttctgca 1008121 agcttttttg tggacaggat gatcagctgc tgaactgctg tgtcgcgaaa caagattttc 1008181 ctgtaagccg aactttctct tctcatttta aaaataattg gtgataatga ttctcattcc 1008241 gtgttatact actcttggac atcttaacca tagaaactac caacaggaga gactggaaca 1008301 tatgaaaaaa acactgatta ttcttacagt tttacttctt tctgtcttaa cggctgcttg 1008361 ctcgtcttca agcggcaatc aaaacagtaa agaacataaa gtggcggtaa cacatgattt 1008421 agggaagaca aatgtgcctg agcatccgaa gcgggttgtt gttcttgagc taggttttat 1008481 tgatacactg cttgatctcg gcattacgcc tgtcggggtt gccgatgaca acaaagcgaa 1008541 gcagctgatc aacaaggatg tgctgaagaa aattgacggc tacacatctg tcggcactcg 1008601 ctcacagcca agcatggaaa aaatcgcttc attaaaaccc gatttaatta ttgctgacac 1008661 gacccggcat aagaaggtgt acgatcagct gaaaaaaata gcgccgacga ttgcacttaa 1008721 taatttaaat gctgattatc aggatacaat tgacgcttcg cttacgattg caaaagcagt 1008781 cggcaaggag aaggaaatgg agaaaaagct gacggcgcat gaagaaaagc ttagcgagac 1008841 aaagcagaaa atcagcgcga acagccagtc cgtgcttttg atcggaaata caaatgatac 1008901 cattatggcc agggatgaaa acttctttac atcgagactt ttaacacagg tcggctaccg 1008961 atatgcaatc agtacgtcag gcaatagcga ttcaagcaat ggcggcgact ctgtgaatat 1009021 gaaaatgaca ctggagcagc tgctgaaaac agatccggat gtgatcatcc tgatgacagg 1009081 aaaaacagat gacctcgacg ccgacggtaa acgcccgatc gaaaagaatg tcctttggaa 1009141 aaaactgaag gcagtgaaaa acgggcatgt ataccacgtg gatcgtgcgg tgtggtctct 1009201 gcgccgcagt gtagacgggg cgaatgccat tttggacgag cttcaaaaag agatgccggc 1009261 tgctaagaaa taaaagaaaa gacaggcaaa cgcctgtctt tttcttattt gataaagccg 1009321 gataagtggc tgttgatatt atagtctttt atccgccatt tttcttctgc aaattcaatg 1009381 ttgctgaggc aggcgttgac gagacgggtg ctttgaagct ccgggtcacc gccggatatt 1009441 tctgtcagca gggcgtgaat tgccgcaccg tgcgccacga tcagcacctt cttgtttgga 1009501 tacgcctgat tcacttttgc caaaccgccc atcagcctgt cagtgagttc ttctaaggtt 1009561 tccatattcg gatagatgtt atctggatag cgctttgtcc gttcctccag cggcatgccc 1009621 tccgcgtcgc cgtaatcgcg ttccttaaaa tcatccatct cgactatcgg aagatgcaga 1009681 tattcattaa taatttccgc ggttcttttc gctcttttca gcgggctcgt cacaataata 1009741 tcccaagaaa agtcctttac atattctccg gtttctcttg cttggcgttc acctgttgcg 1009801 tttagcggga tatcggtttt gccttggcat ttttgctgca ggttccaatc ggtttctcca 1009861 tgtcttacta aacaaacggc tgtcataaaa tccccttcct gactttattc atatcgctat 1009921 tatactaaat cgaaagcgtg tgtcctatga aaaagcctat gcaagaactt caaataataa 1009981 agccagtccg attccgccgc cgcttccgat ggctgcaaca gcatattgac agtctggccg 1010041 tcttttcgct tcataaaaca atctggttac cagagctgca cctgatgcac cgtacggatg 1010101 gccaagagct aaggcgccgc cgcgcacatt gatttttgaa aagggaatgc cgagttcttg 1010161 cgagcagaca caaattttga cggcaaaggc ttcattgatt tcaaataaat cgatatcatc 1010221 aggtgttaca tcgtgtgtat gtaagagctg acgaatcgcg acaaccggtg ccgcgggcgg 1010281 aaagttgggg tgaatgccgc tgacagcgct gccgataaac cgaagcacag gcttaagtcc 1010341 cagggctgct gctttttctt cttccattac caaaagagcg gctgctccgt ctgctatgcc 1010401 actgctgttg gctgctgtga ctgttccgga gctggtgtcg aaaaccggct ttgcacgggg 1010461 aataatcgct tctattggcc gcgttttcaa aaatgcttcg tccgtctcca attccccgag 1010521 agcaacaact tcttcacggt aaaatccttc atcatgcgcg ttcctgctgc gttgatggct 1010581 gagaagcgcg tactcatcct gcatgcttct gctgatggaa tagcgtgcag ccgtatattc 1010641 tgccgcaatg cccatgtctg gatcgccgat cgcatctgga gaaaagcgag cccgttctga 1010701 aaaaggggat tggctgctgc tttctgagcc gcccgcgata tacatcgtgc cggctcccgc 1010761 ttgaataagg ctgcaggcat agcgcacagc ttcaaggccg gagccgcact gtctgtcaat 1010821 tgtcattccg ggaaccgata aaggcagtcc ggcttgaagg gctgacagtc tggccaggtt 1010881 gccgcctctg ccagtagcgt ttccgagaat gacctcgtca acttgatcct ctagctttcg 1010941 gctgagacag cggatgatgg gagccgccaa atcctccggc aggaagggct tcagcagtcc 1011001 gttttgattt ccaaagatcg ttcgttttgc atcaacaata accgcattca tttatactgt 1011061 acactctctt ccagccattt tttcactctg gaacgggcaa tttttccgct gctcgtttcc 1011121 ggcaagctgt ctgcaaacac ccattttttc ggaattttat aggaggctaa tttctgttta 1011181 caccaggctt tcagtgttct ggcattagcg tttccaagaa tgacagctac agcgatttct 1011241 ccccaatact cgtcgggaat gccaacgaca gccgcgcttt caacctctgg gcaggcgaga 1011301 agcacacgtt caatttcttc tgggaaaata tttaatcctc cgtacacgat catcccgttt 1011361 tctcttcctg atatgtatag aaagccctct tcatcaacgt agcccatatc atctactgtc 1011421 atccattcat ctggtgtgct gccgttcaca tagccggaaa acctcatcgg gcttttgaca 1011481 aatatttttc cgatttctcc tggctggcag cgttctcctc cagcgttgcg gatttcgatc 1011541 cggacattat gaaaagggcg gcccgctgaa tgcggcttcc gtttgctgtc ttccggtgaa 1011601 gaaaacgtca caaaactaag ctctgatgtg ccgtaaaaat cgtacagctt gagatgaggc 1011661 catgcagcgg caagcttctt cttggattct gccggccagt ctgcgccgga tgaaatgatt 1011721 ttgacgggac tgtcgggaaa accctcaatc cttgcgaggg cgtctgtcat cgtcggtacg 1011781 gtatagagaa cactgatgga ttcacggcac agccattcct tcgctttggc aggagaaaac 1011841 tttttcagca aacaaacggt tcctccgaga aacaaagtgc tgacagcccc atataggaag 1011901 tgagaggaca ttaacgctcc gggaatcaga accttatcat ctgatgaaat cgaaaaatct 1011961 gtttctgtac aggtaaagct ctccatccat gagcggtgag atcgcgtaaa ggccttcggt 1012021 tttcctgtcg agcccgacgt aaatcccata taaaaagggt gctccggatc aatggtaggc 1012081 aagggatcag cggctgcctc agaaatatct gccatacagt tatccagcaa tacaacaggt 1012141 gtctggctat ctgtcagttt gtttttgaaa aaggctaaag taaccacaag atccgcattg 1012201 cttatggaca gccgctcctt acattcagcc gggctccagc gtgtgtcgat gggaatggcc 1012261 gtacatccag ccgctgcggc tccggcaaac agctgtaaaa acgcgagact atttgggagc 1012321 aggatcgcca cacgattcgg catgctcggc tgtgaccgca gccaatttgc ggtttgagag 1012381 acaagccgat cccaatcatg gtacgtgatt tgctccgatt cagtctggat cgctacacgg 1012441 ccgggcgatg tttcggcagt agatgaatag gtatgagtaa ttgtcatgta ttgtcatcct 1012501 ccttttgtaa acatcgtatc agaaagagac aaggcttgag tgatttttat cgccagaaat 1012561 gcagatacag ccgcttttat caaatcacca ggcacatatg caaggctcat gaaggcggcc 1012621 tgtgacaaat caatatgcat gataaaagct tgtaccggta taccaagcag ataaataaag 1012681 atgatgccga atacgatatg agtgaaaaag agacgcaata ctgtcacctt ccgcagcctg 1012741 ttagcggcta aactgatcag ccatgaagcg aggggataag caatcaaaaa gcctgcgctc 1012801 ggtccgaaaa acacaccaaa accgcctcgt ccgccgggca acagcggcgc tccgaaggcg 1012861 acgagcagca aaaagacaag ctggcttaag aaagcagact ttggcctgag aatgctgcct 1012921 gccaacatga caccaagcgt ttgcaatgta atcggaacgg gtgtaaagga taagaagaga 1012981 gggggcataa agccgagcac tgccatcagc gcggtgaaaa tcgcaatatg catcatgtcg 1013041 attaatttca gcatgtgaaa tcctccaaaa agtaatcaaa tatggttata caataaatgc 1013101 aggtaattat tatgtcaact gatttttaat ttaagtttac ataatgaacg caaaaaaacc 1013161 ggccgtatgg cagaccggtt tttgatggtt attcttctgt caggatgaca agcgaatcaa 1013221 cggaagcggc cacatgggaa acggcgcggc tgacttcctg aagccctcca agaaaggctt 1013281 gcagatcgac gtcgattttg cctgattgct ctttgctgat tttcatgctg tggacgattt 1013341 catcgaataa gcggttaatt tgcgtcattt tttctttact ttcgctgact agctcattca 1013401 cgtctttgat atgcttggat acaatgttga tttgtgtatt cgtattgttc acaagctcag 1013461 aaacagtaga gacggttttt ttcgtatcct cagaaagctt ccgcacttca tttgccacga 1013521 cagcaaagcc tttgccgtgt tctccggcgc gggcggattc aatagatgca ttgagcgaga 1013581 gaaggtttgt ttgttcagct atgcctgtga cgatgccgaa gattttttca atttgctgcg 1013641 cgatttcatc cagcttgacc atttcttttt cgatttggac aaggcttgtg tcaattttgt 1013701 tcatctgttt ttgctggact tctagctctt tttttccgcc gatcgacttt tcttcaacag 1013761 tgctggatgt tacagtgccg gctttggatg cttgagaaat gccttcagat ttgtccacaa 1013821 gctcttgaac tgatctgctt gtttctgaaa acagattggc aatcgatcca gaggtttctt 1013881 gaattttctg atgaagaagg tttttctttt cttcttgttc atcacgggtc tggttgtact 1013941 cgctttgaaa cgcttcaagg acaagctgct gttctaagtt caagattttt gttgttgctt 1014001 taatggcttt tagcagttct tgctgatttg taatggacgc ttcataaatg tcaatcattg 1014061 acaaaaggag ctcttgaaac gcacccatat accattttgg caaaaggccg attcttaaat 1014121 ggatggaggc gattcggtta cgcttttcaa taaattcatc atcgataacg cctgcaaaca 1014181 tttcctgaat atgccgtttt aacgtttgtt ttaagcggtc aactgagctg tgatcattaa 1014241 tgatatccat caatgagctt tcatggtcaa ggtttttata aaacgcatcg acgatattta 1014301 cgatattttc ttgaatgagt ggctgaagct gctctaacac ataaagctca gcatctccca 1014361 acctgaccat tttgagctgt tttttgacat ctgcatgttt gtttgtgagc tgaatgcggt 1014421 ttttttgttg tccgtttgaa tctgaaaagt aagctgtttc ttgttttctg tcttttttaa 1014481 ataacaatac aatgatcccc cttgggaaaa atataatttt tactttttgg ctttttaagc 1014541 ctttttcttt tttatcggcc aagggaaaca tgaatgaagc tgcagatgaa aaatatttga 1014601 aaaaacgttc attaaaatga acggtttaat cgagatctat ttgttttaat ggtttaatgg 1014661 ccggaccctc tacaacttcg ccagatggct taaagcgtga tccgtggcac ggacaatccc 1014721 acgtatgctc actgtcgttc cactcgacct cgcagcctaa atgggtacaa gtcgtatcaa 1014781 cgagatggag gcagcctgtc tcatcacgaa atgctcccgc tcgcctgccg tttatggtga 1014841 cggctttccc ttctcctggc gaaatgtctt caaattggac atcaggcttt tcaagctttc 1014901 cttttatcaa atgcttggcg acatctgcat tgtaggaaat cactttctgc aacccgggat 1014961 tcagatggaa acgggacggc gtgaaaatgc tttcgtatgg gttttctttt ttctccacaa 1015021 ggtctgacaa taaagtggct gcgactgctg aggacgtcat gccccatttt ttgaacccgg 1015081 tcgctactag aatattgtcc tcattttccg acatcggccc gataaacggg attttgtcga 1015141 tcgtcactag atcttgggtg gaccaataat atggaatgct ttcgatgccg atggtgcttt 1015201 cggccagttg tctcagtgtt tcataatgtg tagacatggc ttttccctgg cctgttttat 1015261 ggcttactcc gctgaagaga atcagctttt caccgtttac aaccgtatag cggagcgcca 1015321 ctgacggctg atcgatactc aaatacatgc cctcgggata ctcgatcttc ggcttgatgg 1015381 caaggacata agatctgtcg gagtacattc tcgcagcata taatccgcct ccgtcataaa 1015441 aagggaagtg ggaacagcat atgataaagc ggctcttaat ggcgtgccgg ctttttgtta 1015501 ccacttcggg cctttcgcct tttttgatat caagcgcaac ggtctcttca taaattcggc 1015561 cgcctttttg aacaatttgc tccagaagcg cttttaagta ttgaagcgga tgaaattgag 1015621 cttgattctt catgacaagc gccagcttag aacctaaggg aattggaaga tccttgataa 1015681 ggtctctttc aattccgagc tttgtgtatg cctcatgctc ggtgtggatt ttttgaacag 1015741 cgttttcatt tgccgtataa agatatgcgt cttgctcgat ccattcacaa tcaatttgat 1015801 gttcatccac aatgcctttt atgtaatcaa ttgcgttttg gtttgcttca taataaagcc 1015861 tcgcatggtt taatccgaaa tggcggataa attcgtcgta tatcatgtca tgctgtgcgg 1015921 taactttagc agttgtatgc gcagtggttc cgttaagaac ctgatttgct tcaatcaaaa 1015981 cgacacggaa gcctctcttc gtaagttcat atgccgttgt gattcccgta atcccgcctc 1016041 cgataatggt gacgtcacat tcagtgtcct cttgaagcgc aggaaaagaa ggcaggtcag 1016101 ttgatgtttt ccagtatgtt tcaggtgctt cctttgcaaa atgttgatta gccaagccgt 1016161 tatacctcca atcagattta ttcttaattt ttccatattc tatcttttca tacataggaa 1016221 gcaggcattg ttcataacat aataaggttg aaaaggagtg atttcattgg cgaatcaaaa 1016281 aaagaaaaca ttaccgcctc agcaccagaa ccagcagcct ggttttgaat atctgatgga 1016341 cccgcgtccg gtttttgata agccgaagaa agcgaaaaaa ttagagggca aaaccgctat 1016401 tattactgga ggagacagcg ggattggacg cgctgtctcg gtgttattcg caaaagaagg 1016461 ggctaatgtg gtcattgtgt atttgaatga acatcaggac gccgaggaaa caaagcagta 1016521 tgtagaaaag gaaggggtaa aatgcctgct gattgcagga gatgtcgggg atgaagcgtt 1016581 ttgcaatgat gtggtcgggc aggcaagcca agtgtttcca tccattgata tattggttaa 1016641 caatgcagct gagcagcatg tccagcccag cattgaaaaa atcaccagcc accagctgat 1016701 cagaaccttc caaacaaaca ttttttccat gttttactta acaaaggcag tgctgcctca 1016761 tttaaaaaaa gggagctcta ttattaatac cgcttcaatt accgcctata aaggcaataa 1016821 aacgctgatc gattattcag cgacaaaagg cgcgatcgtt acgtttacaa ggtccctttc 1016881 ccagtcgctt gttcagcagg gcatacgggt caatgcagtg gcaccgggtc ccatttggac 1016941 accgcttatc ccggccagct ttgccgcaaa agacgtggaa gtgtttggtt cagacgtgcc 1017001 gatggaacgc ccggggcagc cggtcgaagt ggcgccaagc tatctatacc ttgccagcga 1017061 cgattccaca tacgtcacag ggcagacgat tcacgtcaat ggcggaacaa ttgtgaacgg 1017121 ataataaaaa gccaatcctt gaaggattgg cttattcgct ctgcttgagc gctgcatatt 1017181 ctttagagag cgtaagaaac gcatctttat ctttttcgtc caaggctttg ttaatttggt 1017241 ccgtcagcat ggcaagccga cggttataca aggattcatc gagcaccatt tgaatgtaaa 1017301 tatccgtcat tgtgacatcg aattcttttg ttttttgcgt gttgcgggac ttcatgagct 1017361 cagtgtacga ttttttctct ttcataaaga atccccccaa tgcctttttt atagtatatg 1017421 gataacggtc gaaaaaatca ataaattttt ataattttta gacaactaat acttggcaat 1017481 ctatcgacat atcctgcaaa atgccgtaaa ccggcaagtc ttatgaaagt aaaatcggtt 1017541 tattactagt catttagtac cattaaatat cattaaaaga tgattttatc ttaaatgtta 1017601 aaaaaacctg tcgttttaca aaaacagatg atagattatt agtataaatt ttgcagaaaa 1017661 aggatggagg ccataatatg agtcagaaaa cagacgcacc tttagaatcg tatgaagtga 1017721 acggcgcaac aattgccgtg ctgccagaag aaatagacgg caaaatctgt tccaaaatta 1017781 ttgaaaaaga ttgcgtgttt tatgtaaaca tgaagccgct gcaaattgtc gacagaagct 1017841 gccgattttt tggatcaagc tatgcgggaa gaaaagcagg aacttatgaa gtgacaaaaa 1017901 tttcacacaa gccgccgatc atggtggacc cttcgaacca aatcttttta ttccctacac 1017961 tttcttcgac aagaccccaa tgcggctgga tttcccatgt gcatgtaaaa gaattcaaag 1018021 cgactgaatt cgacgatacg gaagtgacgt tttccaatgg gaaaacgatg gagctgccga 1018081 tctcttataa ttcgttcgag aaccaggtat accgaacagc gtggctcaga accaaattcc 1018141 aagacagaat cgaccaccgc gtgccgaaaa gacaggaatt tatgctgtac ccgaaagaag 1018201 agcggacgaa gatgatttat gattttattt tgcgtgagct cggggaacgg tattagaaaa 1018261 ataggaagga gctgaccgaa cagggcagct cctttcataa agctatgccg tcggaattcc 1018321 tccggtgatg ccatatacct gagatgtcac atagcttgaa ttctctgaag ctagaaatac 1018381 ataaacatcg gccaattcca ctggctgccc agcgcgattt aatggagctg gcggcgtgcc 1018441 ttgtccgaat ttcgggatgt tttccgtcgg ctgtccgccg gaaatttgca gcggtgtcca 1018501 aattggtccg ggcgcaactg aatttactct gatgcctttg gaagcaagct gttttcccag 1018561 tccgacggta aagccgataa tggcgttttt cgttgctgcg taatctaaca gcatcgggct 1018621 tggattatag ccttcaactg aggtagttgt gataattgaa gctccctccg gcaaatacgg 1018681 aagcgccgct tttacaaccc agtaaaggga aaagacgttc acttcaaatg ttttatagat 1018741 ttgttcagta ggcagatctt cgatgttttc gaccgcttgc tgtttgcctg caacgagcgc 1018801 tagcacatca agtccgccga gttcgtgatg cgactgtttg actagatctt ggcaaaagga 1018861 ttcgtcgctc aagtctccgg ggatcagcac tgcttttcgg ccttctgctt caatcagctc 1018921 ttttacctct tcagcatctg gctgttcctc gggcaagtag ttaatagcca catcggcacc 1018981 ttctctggcg taagcaattg cggcagcgcg gccgataccg gaatcgccgc ccgtgacaag 1019041 cgcttttcga cccgttagtt tacctgatcc tttgtagctt ttttctccgc aatcagggac 1019101 aggcttcatg ttcttttgca ggcctggcgg ttcttgatat tgttcgggaa attcatcatg 1019161 aaaaaatgct tttataggat tcgtaagatt tgaatcagac atcagcaacg ctccttttct 1019221 gtttggtgta cattcgtatg tgtacccctg agcataagca gaaaaacatg ttttggcagt 1019281 ttgaatagtg aaggaaaaag aaaacaagaa aaaacaaagc cttcttccat atttatcttg 1019341 tcaaataaga ctatatgaat tatgataaat tcgagctata aatcaactaa atattgggtg 1019401 ttgggagagt gaatcgtcat gaaaaaagcg gcggcggttt tgctgtcact cggtctcgtt 1019461 ttcggttttt catacggagc tggccatgtg gcggaagcca aaacaaaggt gaaggtctat 1019521 aagaactgca aggagctaaa caaagtatac aaaggcggag tggcccgcac atcgaaggtg 1019581 aaaaacaaag gcggaaaaac gaagtacaag ccttacgttt ctaaggcact ttacgatgcc 1019641 aataaaaaca aagaccgcga taaagatctt atcgcctgtg aacggtaaat aagaaaaagc 1019701 aatctggtgt ccagattgct ttttttatgc ttaggccgcc tgatcggccg cagcgctttt 1019761 cgccttcctt gtcataaggc tgactgccat catgaccgtg atattcaaaa gcagggcgac 1019821 gatgccgaca ttcaagtctt ttgcggcttg cggcagagcc ggaaataaag tgccgatcgt 1019881 cgtttccgtc attgtaatat aagtaactgc tccgacacct gcaataatgc cggcgaaagc 1019941 tccttgcttt gtcaccatat tatgcttgag caggctgaac aaaagggcgg ggaatagctg 1020001 tgtgacaagg ctgtagccca tcaaaagcag cgtaacgatg gtattcccgc ctttgaaggt 1020061 aaaatacacc gaaatcagcg caatcaccgg cactaaaaac ttagcaagcg ccgatacttg 1020121 ctgttctgtc gtgcggggcg cgattacctt gtacacattt tttgcaaaca gtgtggaggc 1020181 ggacattaag atcatagacc ctggcacaag tgctgtcagc agtccggcag caccgataat 1020241 tccgacaaac caagggtcaa atgcttgcag agacagtctc aaaagcgaca aatccccgtc 1020301 tgcgccattc agatctggaa cttgcaggat agccgcaaag ccgacgaaaa ggacgaagag 1020361 caggaccagc tggtacaaag gcatgatgat ggcgttttta cgaaacactt ttgggttttc 1020421 ggctgaatac gaagcggaaa acgtgtgagg ccacatgtaa aaaccaagcg ctgtcaagag 1020481 tacggttgaa ctgaaccagg ccacactttg tcccgattcg gggagcgtaa gaaagccagg 1020541 ctttgccgtt tcaatctgct gaaacatgtc ttgaaatccg ccgtagtaat gaattggcaa 1020601 atacacacct aaaaacagaa cgacaaccag aatcatgatg tccttcacaa ccgatatcca 1020661 ggcagacccg tgaatgcctg aaaccataac ataaaccgtg atggaaacag cgccgatcca 1020721 gatggcagcg gtcggggtga ttttgccgta cgaggtttcc gatacaatca gcccgaggcc 1020781 tttcagctgc agtacaagat agggaatgag tgcggcgatg ccgaccagtg aaacgagaat 1020841 gccaagcagc ggactgttgt atttttttgt gaaaaaatca gactgcgaca tcagtttatg 1020901 ctgtttcgcg tacgtccaaa ctgctggaag aagccagtaa gaaaggatgt aggccagaca 1020961 tccgtaggcg atgatataaa aggctggacc gccttttccg taggcccagc cgctgccgcc 1021021 gagaaacgta aaagtagtat aaatttcgcc tgccatcaaa aggaagacga aaacagttcc 1021081 gaagccgcgc cctccgaccg tccactgctc caggttcatg tcttttcctt tttgggcgcg 1021141 tataccgaga aaaatactca agagcaggac accgaagatg atgatgagag ctgcattcat 1021201 tctgcttcct cctttttatt ttccttgtcg aggacataca caatcgccat cagcgcagag 1021261 gtcaaaagag cccacatcac aatataggca agaataaacg gcatgccgaa cacatagggg 1021321 gtcaccttat ttgcaaaagg gatgccgagt aagattccga taaagggtaa agcggcaaga 1021381 acgtgaatca gtttcataga atcctccttc tatttaggat tgaggtgtac aagcctaagc 1021441 gtactgaaaa tgatgtcgca gatatcgcag cacatgtcat tttttggagt gaaaggctgt 1021501 ggttcgaatt ataaataaat ttattttgtt tgtatagtgt gaattgtctg aaattaatgc 1021561 tctgaatcgc ccgaagaggg aacgggcagt atgattcaaa aggctcagag tctgtctggg 1021621 gcaaatagat agtatgttaa taattcgctg acctgctcac ggattcgcgg attaaaatag 1021681 cgatggtttt cttcataacc gtcgatgaca aatgtataga gtgtaaaggc ctcatcgcgt 1021741 tccgtctcgc ggattgcaat ttttcttttc ctcagttctt ttctgacctc catcaaatcc 1021801 ttttgtgcta tttttaatga ttcgctgata agctgtttat aaggatgctt caattttaat 1021861 gtgctttctt caattccggc gagatcacgg ttaaaaatcg taatggccat gggcaaaaag 1021921 agagcccgtt caattaaatc gtatatttcc tcctgcagat ttggcatatt gactccttct 1021981 ttctaaggga acgtttgttc tatttgtatt ctatatcggc tggtgaaatg tttcaagaca 1022041 gaaaaaatca ccaaaacttt ttagttttct gctgataatg tgtagaataa ggatagacaa 1022101 acccggtaag gagtataaat gttggagcat tttttatcct atttgacaca agaacattta 1022161 actgaattat ttcaaagcta tagggctttc ggtccgctca ttgctgtgct gctgccttta 1022221 attgaagcat ttctcccgtt tttgccgctg atcgtgtttg tggtggcgaa tacgaactcg 1022281 tttggcttgt gggaaggatt catcctatcc tgggcgggat caactgctgg ttccattctc 1022341 gtctttttga ttgtccgtca atacggacag agaaaattgc ttggatttat ccgcagtcat 1022401 ccgtctgtca gaaagctgat gttatgggtg gaaagacacg gcttcggtcc catgtttctt 1022461 ctgctttgtt ttccatttac accgtcagcc gcggtgaatg ttgttgccgg tttgtcaagg 1022521 atcggaacgc ggccgtttat tttggcggca gcctcgggga agcttgtcat gatttttatg 1022581 atcagcttca tcggatatga tctgcacgcg ctgattacac agccgattcg aacggtcatc 1022641 gccgtattgg tgatcactgt cttatggtat gtcggcaaaa aggtggagcg gtatctgcat 1022701 gtaagagcca gtcagcgtga gcatgatgga gggagacagt aacatgaaaa aacggttttg 1022761 gtttcttgcc ggtgtagtgt ccgttgttct cgccattcag gttaaaaatg ctgtctttat 1022821 tgattacaag gtagaaggcg tcagtatgaa cccgaccttc caggaaggaa acgaattgtt 1022881 ggtcaataaa ttttcgcatc gatttaaaac catccatcgt tttgacatcg tcctttttaa 1022941 aggccctgat cataaagtgc tgattaaacg ggtaatcggc ttgcccggtg aaacgatcaa 1023001 atataaagat gatcagctgt atgtgaacgg aaagcaggtt gctgagccat ttttgaagca 1023061 tttgaaatct gtttctgccg gcagccatgt aacgggtgat ttttctttga aagatgtgac 1023121 gggaacaagc aaggtgccga aaggaaaata ttttgtcgtt ggagataatc gcatatacag 1023181 cttcgacagc cggcattttg gtccgataag agaaaaaaat attgtcggtg tgatttctga 1023241 tgccgaataa aaagacgcta attgaagagg cgtctttttg tatgccgttt ggaaaaatgt 1023301 gttgaagaaa aatttgtaag gagctataat caaaattgtt acctgtgtaa caaaatttat 1023361 atattttttt gactggaggg ccgtttttat tggtttttgt tcgtttttca tgaaacaaaa 1023421 ggagtggtga atgatgatga aatatgaagc agtgattata ggaggagggc cggttggatt 1023481 tatgctggct tctgagcttg caatagccgg agtgggaaca tgtgtgattg aacggcttga 1023541 aaaacctgtt ccgcattcca aggcgttgac gctgcacccc cgaacgctgg agcttcttga 1023601 gatgagaggg attttagagc ggttcgtatc caagggaagc aagataccta ccggacattt 1023661 ttcaatgctg gatacccgtc tggatttttc aggcttggat acgagctgtc cttacacgct 1023721 tttgctcccg cagtccaaaa cagaaaagct tcttgaagat catgcacgaa gcctgggaac 1023781 agaggtgttt cggggtgccg aggcgctggc ggttacgcaa aacggggaag cggtccaaac 1023841 aatttttaag gatcgggacg gcagtgtacg gacgatcaca agcaagtttg ccgttggggc 1023901 agatggcgcc gggagtaccg tccggaaaca ggcgaaaatt gagtttccgg gaacagacag 1023961 cactgtcacc gctgcgcttg gggatgtggt gctcctttct ccgccgccgt caggtgtgct 1024021 gtccctttgc acaaaagagg gcggtgttat gattgttccg ttatctccag accgataccg 1024081 tgtcgttgtg atcagccctt atcgcacaca aacgccgaaa gatgtgcctg tgactgagga 1024141 agagctgaaa gctgacctcc tgcgaatttg cggaactgac ttcggtttaa ccgacccttc 1024201 gtggatgtcg cggtttggga acgccgcgcg ccaagcgaaa cggtatcggg acggcagaat 1024261 ctttcttgcg ggtgatgccg cgcatattca ttttccggcg ggcgggcaag gactgaatgt 1024321 cggccttcag gatgcaatga acctcgggtg gaaactggcg gcggccatca aaggctctgc 1024381 gccttcttgg cttttggaca gctaccatga tgagcggcat ccggcagcgg aagggctcct 1024441 cagaaacacg gaggcacaga caaagctgat cgatttcact caagcaggcc tccatttgcg 1024501 aagcatgatg tcggagctgc tggccttccc tgatgtgaat cgatatgtag cggggcaaat 1024561 ttctgcgctc gatgtcagat atgaagctga tcgtaccatg ccgccgaatc gtttgaacgg 1024621 ggcaaggctc cctgacatga agctgattct ttccgacggc aattcggaac ggctgtacag 1024681 ctttctccaa aacgggacat tcgttttgct gtcattgagg caggaagctg atgatcatat 1024741 cgaagtaaaa ggcttacgta cggtaaccgc ctcgcttgca gaaccgaatg aaaagttgcg 1024801 gaatgtgcat accatattga ttcgtcccga tggacatgta gcctgggcgg tggatgcatc 1024861 agcgcccgat tgttccgagg tgattcaaaa agggatcagc cgctggtttt ccgtcaccag 1024921 ccgagtataa ttcaattcga ttgtttcatc tgtaacaaaa cggtatgata gaagaaacaa 1024981 tcgaatgaaa aaggatggaa aacccgatga acacagatca tacgaaacgc aatctttttg 1025041 aattgtatgc ggagctcatt catcagcagg agaaatggga ggggcttatt aaagcctttt 1025101 tatctgacga attgaggaag ctggatgtag agcacgggag taaatctcaa ttgacgatga 1025161 cagaaattca tgttctatcc tgtgtcgggg acaatgaacc aattaatgtc acgtcgatag 1025221 cagaaaaaat gaatacgaca aaagcgactg tatcacgcat cagcacaaaa ttgctcggcg 1025281 caggcttcct tcacagaaca cagctcagcg ataataaaaa ggaggtctac ttccgattga 1025341 cgcctgctgg aaaaaagctg cacagtttgc acaaatatta tcatcagaag gctgaacagc 1025401 gttttctgtc attttttgac cgctataccg aggaagagat tctttttgcg gaacggctgt 1025461 ttcgggatct ggtgacaaaa tggtatccgt cgtcagaaga aattgaaggg gggcttccta 1025521 gcatttttaa ataaaaaaca cgcactgcgg tgcgtgtttt tcgctttgcg gccgcctcga 1025581 gaattctttc atttcaccct ctggcagcac tcacttcaaa tctgatccat taacaacgaa 1025641 atatccgctt atatttcctc atctcgatgg tttgcgaatt aaaagttctt gaaccctttt 1025701 ttcaactagg cactactgcc gctgattgag ctctttttgt cttttttttc accatgaaga 1025761 tggtgaagca ggcgataaaa cggcggcagc agggcaataa ccagaatgac gcgaatgacc 1025821 tgaaccgcaa cgacaaaggt ggaatcagca tgtaaggtaa ctgacgtcgt cgccatctct 1025881 gcaatcccgc cgggcgcaaa tgccagaaca gaagtgatga gcgaaattcc tgtcagctcg 1025941 gaaacgatca cggcgctcaa aaacattgct gcgattaaac cgacggacga gacaaacccg 1026001 acgatgataa tacgggtgac gccggcaaac atgcttttgt acatcttaga gccgatcgtt 1026061 gccccgagaa atacttgtga tacatggtta gcttgtgaca accaccatgc cgtcatgtcg 1026121 tgccctgtca ccgcagctcc gccaacatgt acaattgcta caccgagcat gctgccgagc 1026181 agccatggag ctggaaattt taaaaatttc gcagctttgc aagctcccca ggcagcgaga 1026241 ataagaatga cggtccacaa aacgggagcg agcctaaaat ctgtcgttgc agaagaaatc 1026301 gtctctgctg cggcacttgc ggtacgatct tgttttgtat agatcagaat gactaaaaac 1026361 ggaatggaaa gcaccacgag cagcacacgc atcatttgaa cgaggctgac tatagcggta 1026421 ttggcgccta cttcctgtgc gatgctcggc atggcggaaa gtccgccggg agcggtgccg 1026481 acaaagctag tcatcatatc cgttttgctg aaacgccaaa gcacatatcc tgacagcatg 1026541 gccagcagga tagacaatat cagcataacg ccgactgaaa accaatggtc tttgagaaca 1026601 gagagaacgg ataaattcag cttttggccc aattcgatgc cgaggatcat ctgcccgagg 1026661 gcgagccatc gtcggttaat tcctttttgg tctggtgcca tcatcagcca tgccggccgt 1026721 atcatggcga ggcagcaggc gacaatcagt gttccgatca tccatccaat tgatattccg 1026781 gttaatgaaa gaataaaccc cccggctgca ctgattgcga taaaccatag atctttgagg 1026841 agattttcgt ctttcttcaa tgtaaaaccc ttcttccttt ttcacgtaac actccaattg 1026901 ttcacgtagt gaatgtattt attactatag tatatttttg ttgataaaga aattatgaat 1026961 tattttctat aagcgattca cttttcttat gaccttgtgt tcgagctttt ctattgtgta 1027021 agtcagagat aaacccgctg tcagcagaca cacggcaaga gcgtaaaaaa tcacttctcc 1027081 gccaaatgat gtcaggatca gcccgcctgc cagcggtccg attgagcggg atatatccca 1027141 atgcagacca tagacagcat aaaaccggcc cagcaaatga ggcggcgcca atttcgatat 1027201 gaaggtctgg atgtgggtta gcccgatgct ttcaccaacc gtcatcaccg ctgccgtcac 1027261 taaaagcatt gtcagagagg ttgagcatgc aaagccggct gccgcaaggg agtagcaaat 1027321 ataagtaatg aagaggatcg ttttcattga aagcttttcg gtccctttga caagaggtac 1027381 ttggagaaca cagctgaata aagcttttgc tgctgaatag atggtcagca tggacagata 1027441 atcagaaaac atgtttttgc tgaacagcct gtatgttgtt tctgtttgtg catataacat 1027501 gctgatgggg agagaaagca gcaaaagaag caggacaggc ctgtatattg taaagctcgc 1027561 ggacattttc ggggtaacag ctgggtgtag cggctttgtc tcaggcagtt tcagtgcagc 1027621 gatcagaaag tagataaaca atgctgcagc atctaatgcg aatatccaca cggggttatg 1027681 attgtacagc agcatcccca ctagcggtcc tgccgtcaga cccgtcgaat agatcgcatt 1027741 gatgaccgca aacacttccg aacgtctgct ttccggcgtg ctttcagcga tttgggcgcg 1027801 ggaagcggga atgtacaacg atcttccgat gccattcatg acatagagaa tagcgaaaac 1027861 atacgcatgc tcagcaaata caaaccctgt cattgccgct gattgaagaa gcaatgcggt 1027921 caaaatcgct gtgcgccgcc caagccgatc cgtcacccgt cctgcagcga gcgtcaggaa 1027981 aatatcagca aatggctgaa ggctgatgat cagcattggc atcatgatac tgccgtttaa 1028041 ttgttcatgc agatacagca ccataaaagg tcccatcatt gcacctgtca ggcttgtcag 1028101 caattcgccg aaaaagcgga gccgaacggg agcggtatat ctcgatttta tagagtgaaa 1028161 actggtcaac atgtgatcgc cgcctttcgc tgtttgatat agtagtagtg tatagaaggg 1028221 gcggcggccc aaaaagtgaa gaaaagaaga gataaaagtt ccccttttgt cgggaggtgc 1028281 ggggattgaa gctgatagag cactacgtgg cgcttgtaaa aacaggctgc gccgagtatg 1028341 ggcaaatgaa cgaaatgacg ctcactgaga ttgccgactg tttattttgt acagaaagaa 1028401 atgcaaagct cattttacat aagctggaga acagcaattg gattatccgg gaaagcgggg 1028461 cggggcgcgg ccgcaaatct aaaatcgcgt ttcttcggag gcctgaggaa ctgcttcttc 1028521 aaactgcaaa ggaatatacc atgtcaggaa agcttaaaaa ggcaaaggag ctgcttcagc 1028581 agtatcagtc cgcgtttcca gggcttcaaa acgaatataa catgtggcta tcagaggtat 1028641 tcggatttgt gacggagaca ggcgagaatg gggcgaagga tgtcctgcgg ctgttcatca 1028701 cgcctgaatc tgtcagcagt ttggatccat gccaaatatt tttgcggtct gagggccatt 1028761 tcgtcaaaca gatatttgat acactcttca cgtttgattc ggatatgcag gagccgaagc 1028821 ctcatttggt tcatggatgg gaagaggtcg gaaaaaaaca atggagattt tttcttcgaa 1028881 aaggtgtgtt atttcataat ggacagccgc tgacatcgcg ggacgttgcg tttacatttc 1028941 agcgcttttt ggaactggct gacaacccgt ataaatggct tctgcacgga gtgaaacaag 1029001 tcttagaaaa gggcccttat tgtgtggagc tcatactcga taagccgaat gcgcttttgc 1029061 cgtatgctct ttgtgatgaa cggctgtcca tactgccggc agaacagggc ggcgggaaaa 1029121 atggaacagg gccttttcag atgaatcagc aacatagcgg gatgcttgtg cttgaagcca 1029181 atgagcgcta cttcaaggga cgcccctatt tggatcgcgt tgagtttgtg ttttctgagc 1029241 aagccggaga gatgaacggt tttaccattc aagaaaaaca aacatgtcct gagcagcaaa 1029301 ctgtctttga tgagcggcat gttcagtatt tgtcgcttaa tctgaaaaag aaggggcctc 1029361 ttcagcaccg aagctttaga aaagcgctcc ggctgctgat ttcctctgaa cggctcgttc 1029421 gtgaagcggg agggcaccga agaattccgg ttacgtcctt tttgcatccg agtccttttg 1029481 agtgggaggg cgtttcgcca tctgaattgt tgaaaaaaag cggatacgag ggcgaaacaa 1029541 tcgtgcttta taccttttcg gaaacggatc atcgtgagga cgccgaatgg attcaaaata 1029601 tttgcgccca gcacggtatc aggcttacac ttcaattctg tgatgctgct gatctgcgac 1029661 ggccggaaat cgtgcagatg gcggatatca ttcatgacag tgcgacgttt tatcaagaca 1029721 gcgagtttgg ttttctgcat ttgctgctgt cggagaacag tttcttgtat cagcatctat 1029781 ctgaaaagct gacacagatt tgctcaggaa tgacagagcg gatgttttcc atgcctgacc 1029841 gctgttcgag aatcaacatc ctgcgtgaca ttgaccggca gatgatacag gagctgaacg 1029901 cgatcccgct gtatcaaaat gtgctccagg tgacatcaag taaaaatgta aaaggcctgg 1029961 tgcttgatga agagggatgg attgatttgt actccgtatg gctgtccaaa taaaaagagg 1030021 gttctttttt gaaccctctt ttttacgctg ccatgctgcg gcattgttca gcacaggtga 1030081 agcaggcttt cgcacatgct tggcaatgat catgatcgtg ctttccgcat tcagtgccgc 1030141 atgcttcaca aatatcggcg caaagtgcac aaatttcttt cataaacggg ctgtccgttt 1030201 gcatggcttt gaccgccagc gcgcaaatat ccgcgcattc cctgtcaagc cggatgcatc 1030261 cgctgagatg atgctgcacg ctttcttcca agcatttagt gaaacaatga ttgcaagcct 1030321 tcatgcaatc gatgcaagcc tcaatacaag cctcagaata ttgctccatg gttgattccc 1030381 cctgtatgac agtatatggt tttatgtttc acggctgcat ttgaaaaaaa caggggagtg 1030441 tgtttttagc taaggggata tgtacatata ccctgaatgg gtatatctaa cgttccatca 1030501 gatagtatag gaaccagaca gcgtgatttt gttcatcacg tgctgcgcgc gtaaagacgc 1030561 ctttcgcttt taagtttgac gtttcctcgg ccgcacgcaa gtaaaagtcg acggtttctt 1030621 gttcatcttt aaaagcggcg tccagtcctc ttgtgaaatt gtccgggcat tcttccgttt 1030681 gtttcggcat gatgtgtttg ccggtaattg aaccatacag tgtggaaaat tcacggaggt 1030741 ggcgaatctc gtcacgcctg atttcttcaa tctgttttct gacctcatcg ctgtgggcga 1030801 gttcggcaag cttgcggtag cattgaatag cactgaattc tccgttgatg gccttctgca 1030861 aattccgaat caaaacagga tcttcccggt atggcaccgg atagggatag tagctgtaat 1030921 gcaaggggat tcaactccat tcttaggaat tgggcttctg taaaagtata tgttgggcag 1030981 ggagagatgt gcggagataa tcagcttttt atatgtgaaa aggccgtttt taccaataga 1031041 tcagattggt cattttcgtc aacattcgat aaaatataga gagataaaaa gagaggggtc 1031101 ttctaatttg ggagcagagt ttttagtagg caggtccggg agtggaaaaa cgaagctgat 1031161 catcaacagc attcaggatg aattgcgccg ggctccattc gggaagccga tcatttttct 1031221 agtcccggat caaatgacgt ttttaatgga atacgagctt gctaaaacgc cagatatggg 1031281 cgggatgata cgcgctcaag tgttcagttt ttcacgattg gcctggcgcg tcctccagca 1031341 tacgggagga atgagcaggc cgtttctgac gagcaccggc gtacaaatgc tcctgcggaa 1031401 gctcattgag gagcataaac aggagttcaa agtctatcaa aaagcgagtg acaaaagcgg 1031461 gtttaccgca caggttgagc ggatgctgac agagtttaag cgctattgtc tggaaccgga 1031521 ggatatccgc cggatggcgg aaagcggaac ggcttccgag tatcgcggag aacgtgtttt 1031581 atctgaaaag ctccatgact tatcaattct gtatcagcaa atggaaaaaa gcctcgcaga 1031641 tcaatatctt cactctgagg attatttgac attgctggca gagcatatcc cgcttgcgga 1031701 agatataaaa ggcgcccata tctatgtgga tggcttttat cagtttaccc cgcaggaatt 1031761 cagggtgttg gagcagctta tggttcatgc ggagcatatc acgttttcgc tcacagcgga 1031821 caagccgtca tatgagcggg agccgcatga actggaattg ttcagaatga cggggaaaac 1031881 ctattaccgc ctgcatcaga aggcgaagga actgaatttg gacattacgt ataaagagct 1031941 gagcgggact gagcggcata caaagacgcc ggaattggcg catctagagg cacagtatga 1032001 agcgcgtccg gccattccat acgcagaaaa acaagaagcc cttactgtga tgcaggccgc 1032061 aaacagacga gctgagctgg aaggcattgc tcgggaaatt cacgccctag tcagagagaa 1032121 gggatatcgc tataaggatg tagcaattct tgcgcgccag ccggaagact acaaggatat 1032181 ggtgaaggaa gttttcgcag attacgagat tccttatttc attgacggaa aagcatctat 1032241 gctgaaccat ccgttaattg aatttatccg gtcgagcctt gatgttctga aagggaattg 1032301 gcgttatgaa gcggtgtttc gctgcgtgaa aaccgaactg ctattcccgc tcaatgaacc 1032361 gaaggccaaa gtgagagaac aggtcgatca gctcgaaaat tactgtatcg cctatggtat 1032421 taaaggcgac cgctggacaa agggcgatcg gttccaatac aggcgttttg tgtcattgga 1032481 tgatgatttt gcgcagactg atcaggaaat cgaaatggaa aacatgttga atgacacccg 1032541 cgattggatt gttccgccgc tttttcagct tcaaaaacgc atgaaaaaag cgaagacggt 1032601 tcaagagaag gcggaggcgc tctatcgtta tttagaagag acggatgtgc cgctgaagct 1032661 ggatcaggaa aggcagcgtg ctgaggatga cggcagaatc attgaagcgc agcagcatca 1032721 gcaggcgtgg gacgcagtca ttcagctgct tgaggagttt gttgaaatga tgggagatga 1032781 tgagatttct cttgatttgt ttcagcaaat gatagaagcc ggcgcggagt cgcttacatt 1032841 ttctctaatt ccgcctgcgc ttgaccaggt gtttgtcggc aatatggatt tgtccagaat 1032901 gtatggcacc tcctgcacct ttgtgctcgg ggcaaacgac ggcgttctgc cggcacgccc 1032961 tgatgaaaac ggggtcctgt cggatgatga ccgggaatgg ctgaaaacga ttggggttga 1033021 gctatcctca ggcggacgag agcgtttgct tgatgagcac ttcctcatct acatggcgtt 1033081 ttcaagtccg tctgaccggc tttacgtatc gtatccgatt gctgatgcgg aaggaaaaac 1033141 gcttttgccg tcgatgatcg ttaagcggct ggaagaactg tttccgcatc ataaggagcg 1033201 cctgttaaca aatgaacctg aacaggtcag cgatgaggaa cagctgatgt atgttgtgaa 1033261 taaaagcgtg gcacagtcct ttaccgcgag ccagctcagg ttatggactc gggaatacga 1033321 catcagcgac gtctggtgga gcacgtacaa tgtgctgatg agtgagcagg acaggctgca 1033381 atcgaaaaag ctgttctcaa gcctgttttt ccggaatgaa gtgaagcagc ttgaacgcag 1033441 cgtgtcgaga cagctctatg gtgaacgtat tcagggcagt gtatcgagaa tggaaacctt 1033501 taacgcatgc ccgttttccc attttgcgtc acacgggctg catttgaagg aacggcaatt 1033561 cttcaagctt gaagcaccgg atatcggcca gctgtttcat tccagcttaa agctgatttc 1033621 ggacaggctg cgtgagcaaa agctggattg gcgcgattta acgaaggagc agtgcgagct 1033681 gttttcctat gatgcggtag agcggctggc accgaaactg caaaaggaaa ttctgctcag 1033741 ctcaaaccgg cattattatg tgaaggaaaa actgcaaaaa attgtgacac gtgtgtccgg 1033801 cattttaagc gagcatgcga aagcgagcgg attcgtaccg atcgggcttg aactgggctt 1033861 tggaggaaaa gggccgcttc cgccgctgac ctttcaactg aaaaacggct gtacgatgga 1033921 actcgtcggg cgaattgacc gtgttgataa ggctgaaagc tcaaaaggcc tgctcctcag 1033981 gattgtcgat tataaatcaa gcgacaaagg ccttgactta gcggaagtat attacggatt 1034041 ggcactgcaa atgctgacgt accttgattt atcgattaca cattcagctg actggctcgg 1034101 gatgagggcg acgcctgccg gagtgctgta tttccatatt catgacccga tgattcaatc 1034161 taatctcccg cttgggcttg acgagattga acaggagatc tttaagaaat ttaaaatgaa 1034221 gggcttgctc ctcggtgatc aggaagtggt tcgcctcatg gatacaaccc ttcaagaggg 1034281 acgttcaaat atcataaacg ccggcttgaa aaaagacggc tctctcagat cagactcagc 1034341 agcagtcggt gaaaaggaat ttgatctttt gacaaagcat gtgcgccgca ccttccaaga 1034401 agcgggcgaa caaatcaccg acgggcgcgt atccattgag ccgtacaaaa tgaagaacaa 1034461 gacgccgtgc acatactgtg cgttcaaatc agtatgccaa tttgatgaat cactggaaga 1034521 aaacgagtat cgcccattaa aggctgaaaa ggacaagaca atacttgagt ggataaaaaa 1034581 ggaggcggat ggcaatgaac attcctaaac cggcagacag cacatggaca gatgaccaat 1034641 ggaatgccat tgtttcaacc ggccaggata ttcttgtggc agcggctgcg ggctctggta 1034701 aaaccgctgt gctcgttgaa cgaatgattc ggaaaatcac cgcggaggaa aacccaatag 1034761 atgtagaccg tcttctcgtt gtgacattta caaacgcctc agcggcagag atgaagcacc 1034821 gaatcgcaga agccttggaa aaagagcttg tacagcgccc cggctcgctg catattagac 1034881 gccagctgtc tcttttaaac cgggccagca tttcgacgct ccattccttt tgcctgcaag 1034941 tgctgaagaa atattactac ttgatcgatc ttgatccggg ctttcggata gctgatcaga 1035001 cggaaggcga gctgatcggg gatgaagtgc ttgacgagct gtttgaagac gaatacgcaa 1035061 agggcgaaaa ggcgtttttt gagcttgttg accgctatac gacagaccgg catgatctgg 1035121 atctgcaatt tctcgttaaa caggtgtacg agtattcccg atcccatccc aacccggagg 1035181 cgtggctgga aagctttgtt catttgtatg atgtatcaga aaagagcgcc atcgaggagc 1035241 tgccgtttta tcaatatgtc aaagaagata ttgcaatggt gcttaacggg gcgaaggaaa 1035301 agctcttgcg cgcgcttgag ctgacgaaag cgccgggcgg cccggcgccg cgtgctgaca 1035361 attttcttga tgatcttgct cagattgatg aactgattca gcatcaggac gatttcagtg 1035421 aactatataa gcgggtgccc gccgtctctt ttaagcgtgc caaagcagta aaaggggatg 1035481 agttcgatcc agcgctcctt gatgaggcga cagatttgag gaacggcgca aaaaaactgc 1035541 ttgaaaagct caaaaccgac tacttcacgc gaagtcctga acagcacttg aaaagcctag 1035601 ccgagatgaa gcctgtcatt gaaacgctcg tacagcttgt catcagctat ggaaaacgat 1035661 tcgaagctgc gaaacaggaa aaatcaatca tcgatttttc ggatttggag cattactgtt 1035721 tagcgatttt gacagctgag aatgacaaag gtgaacgtga gccgagcgag gctgcaaggt 1035781 tttatcagga acagtttcat gaggtgctcg ttgacgaata tcaggatacc aacctcgtgc 1035841 aggaatcgat tctgcagctc gtcacaagcg gtccggagga gactggtaac ctgtttatgg 1035901 taggagatgt caaacagtcg atttatcgat tcaggcttgc ggagccgctt cttttcctct 1035961 ctaaatacaa acggtttaca gagagcggag aaggcacggg gcggaaaatc gatttaaata 1036021 aaaatttccg aagccgggct gatattttag acagcacaaa ctttttattt aaacagctga 1036081 tgggcggcaa aatcggtgag gtcgattatg acgagcaggc tgagctgaag cttggtgcag 1036141 cgtatccgga caatgacgag acggaaacag agctgctgct gatcgacaac gcagaagata 1036201 cggatgcaag cgaggaagca gaagagcttg aaacggtgca gtttgaggca aaagccatcg 1036261 ctaaggaaat tcgtaagctg atttcatcgc cgtttaaggt gtatgacgga aaaaagaaaa 1036321 cacatcgcaa tattcaatac cgagatatcg tgattttgct ccgttcgatg ccgtgggctc 1036381 cgcaaatcat ggaggagctg agagcacagg gcataccggt ttacgccaat ttaacgtcag 1036441 gctattttga agcggtcgaa gtcgccgtcg cgctttctgt gctgaaggtg attgataatc 1036501 cgtatcagga tataccgctt gcctctgtgc tgcgctcacc gattgtcgga gcagatgaaa 1036561 acgagctgtc tttgatccgg cttgaaaata aaaaagcgcc gtactatgag gcgatgaaag 1036621 actacctggc tgctggtgac cggagcgatg agctttatca aaagttaaat acgttttacg 1036681 gacatctgca aaaatggcgc gcgttttcga aaaaccactc agtatctgag ctgatttggg 1036741 aagtgtaccg cgacaccaaa tatatggatt atgtcggcgg catgccgggc ggaaaacagc 1036801 gccaggccaa tttgcgtgtt ctttatgaca gggcgcgtca atatgaatca acggcatttc 1036861 gcggcttgtt ccgtttcctg cggtttatcg aacgcatgca ggagcggggc gatgatcttg 1036921 gtacggcgag agcgctcagc gagcaggagg atgttgtccg cttaatgacg atccacagca 1036981 gcaaagggct cgaatttcca gtcgtgtttg tagcaggtct cggccggaat ttcaacatga 1037041 tggatttgaa caaatcgtac ctgctggata aggagctcgg atttggcacg aagtatattc 1037101 atccgcaatt acgcatcagc tatccgacac ttccgctcat tgcgatgaag aaaaaaatgc 1037161 gcagggagct gctgtcagag gaattgcgtg tgctctatgt tgcattaacg agagcgaagg 1037221 aaaagctgtt tctgattggc tcatgtaagg atcatcagaa acagcttgca aaatggcagg 1037281 catccgcgtc ccaaactgat tggcttctgc cggaatttga ccgctatcag gcgagaacgt 1037341 atctagattt cattgggccg gctcttgcca ggcacagaga cttgggggat ttggctggtg 1037401 tgccagcaca cgctgacatc tcaggtcacc cggctcgttt tgccgttcaa atgatccatt 1037461 cctatgattt gcttgatgat gatctggaag aaagaatgga agaaaaaagc gagcgcctag 1037521 aagcgatccg ccgaggtgaa ccagttcccg gctcgtttgc gtttgatgaa aaagcccgcg 1037581 agcagctgag ctggacctac ccgcatcaag aagtgacgca aattcggaca aagcaatcag 1037641 tttctgagat caagagaaaa agagagtacg aggatgaata cagcggcagg gcccctgtaa 1037701 aaccggctga tggaagcatt ctgtacagac gtcccgcttt tatgatgaaa aaaggcctga 1037761 cagcggcaga gaaagggact gccatgcata cggttatgca gcatatcccg ctgtcacatg 1037821 tgccgtcgat agaagaagct gagcagacgg ttcacaggct ttatgaaaaa gagcttctca 1037881 ctgaagaaca aaaagacgct attgatatag aagaaatcgt gcaatttttc catacagaaa 1037941 tcggcggaca gctgatcggt gctaagtgga aggaccggga aataccattc agcttagcgc 1038001 ttccggccaa ggagatctat cctgatgcac acgaggcaga tgagccgctt ttagtgcagg 1038061 gtattattga ctgtctctat gaaactgagg acggattata tctattggat tataagtcgg 1038121 accggattga gggcaaattc cagcatggat ttgaaggagc ggccccgatc ttgaagaaac 1038181 gatatgaaac gcaaattcag ctgtacacga aggcagtgga gcaaattgca aaaacaaagg 1038241 taaagggatg tgcgctttat ttctttgacg gagggcacat tctgacatta tagcgagatc 1038301 cataagctcc ggaatttcag gcggagcggg tctcgttttc tatataaaag agaggtgaaa 1038361 gcatttgcgg attttacata cggctgactg gcatcttgga aaaacgcttg aaggaagaag 1038421 caggctgagt gaacaggccg atgtgctgga tgaactgaat acgattgtaa aggatgagca 1038481 gatcgatgcc attgtaatgg cgggggatgc atttgacacc gtaaacccgc cagctttagc 1038541 cgagcagctg ttttatgaaa gcctgtctgc gcttagcgac agaggaaagc gcccgatcgt 1038601 cgtcattgcc ggaaatcacg ataatcctga ccgtttgtcc gccgcttcac cgctgacaca 1038661 tgaaaacggc attcatttaa tcggttatcc gacaacagag ccgattcata ttgaagtgcc 1038721 ttcagcagga gagcttttgg cggttggagc gctggcgtac ccatctgaag cgcggttaaa 1038781 tgaagtgcta tccgatacgt ttgatgaaaa gctgctccgt gatcactatg atgtgaaaat 1038841 caggcaggcg tttgagcata tgacaagccg gttccggacc gatgcagtga agattgccgc 1038901 cagccatatt tatgtggcag gcggaaacca aaccgattca gagcggccga ttgaagtcgg 1038961 cggtgcatac acggtggctg ctgaaagcct gccggcagat gccgcttacg ttgcgctcgg 1039021 ccatttgcat cgcccgcaaa cgatcaagcg ggcgcggacg cttgcgcgtt attcaggatc 1039081 tccgctcgcc tacagctttt ctgaagcggg ctacgctaaa tcagtgacga ttgtggacgc 1039141 aaagcctggg gaagaggcca cttggcaaga ggtgttatta tcaagcggca agccacttgt 1039201 gaagtggaaa gcggcaaatg gattaagtga ggtgtacagc tggctggatg aaggcagaga 1039261 tcagaatgct tggattgact tggaaatccg tgtcgcggac cagctgtcac ttgaagagat 1039321 tcacaggctg cggaaggcgc acccgggctt tatccatatc aggccggttt ttgaagaaca 1039381 gaacaaagac cgggaacgga tcgaggttaa acatgtctca atcgaggacc gctttaagaa 1039441 attttatgaa aaacaaactg gcggtgcggt gccggatgaa gaaatggtga agctgttttt 1039501 agagcttgca tcaggcgttg aagaggagga tgcgaaatga agccgatcgc cttaagcatt 1039561 aaggggctcc acagctttag agaggagcag acgatagatt ttgaaggcct ttccggtgcc 1039621 ggtgttttcg gcattttcgg cccgacagga agcggtaaat cctctatact cgacgcaatg 1039681 acgcttgctt tatacggaaa ggtggaacgg gcggcgaata atacgcacgg aatcttaaat 1039741 cacgccgaag atacgctgtc tgtgtccttt acctttgcgc ttcagacgaa tcaccaaatc 1039801 tcatacaaag tcgagcgtgt gtttaagaga acggatgaaa tgaaggtaaa aacggcactt 1039861 tgccgcttca tcgaaatcaa ggacgagcat acggtgctgg ctgataaagc cagcgaagtg 1039921 aataaaagag tggaggagct cttagggctg acgatcgacg attttacgag agcggtggtg 1039981 ctgccccaag ggaaatttgc tgaatttctg tctttaaaag gggcagagcg caggcatatg 1040041 cttcagcgtt tatttaattt ggagcaatat ggagacaggc ttgtgaaaaa gctgagacgg 1040101 caggcgcagg aagccaatgc gagaaaaaat gaaatgcttg ctgaacagtc cggtctcggt 1040161 gaggcgagct cagaggcagt ggagcaggct gaaaaggttc tcgaacaagc tgaagcccgg 1040221 ctggaagcga tgaggaagaa ccgtgatcag gcgaaggagc ggtttacaga gcatcaggag 1040281 atatggaatg tccaaaagga aaaatccact tatgaagaag aggaaaaacg tctcgcagaa 1040341 gaacagccgc atatagacag catgcaaaaa cgcctgctgg aagcagaaac agcagcagcc 1040401 cttaagccct atgcggaccg gtacgcagaa gcgatccagc atgaggagca agctgaaaag 1040461 gaacaaacgc tagcccaaaa ggatttagca gaccggacag ctttctttca gcaaaaacat 1040521 gaagagtatg aagcgtggcg ccagcataaa agcgagaaag agcctgagct tttagccaaa 1040581 caggaacagc tttcacgctt gcaggaaatc gaaatcaaac tgagtgaggc caagcaagag 1040641 gaagagcgca aaaaggctga cctccggcag aaagaagagg ctcttcaatc tgtcatgaat 1040701 gaattagaga ccgtaacaga ccgcctgaca cgagggcaaa acagacagac agaattgaag 1040761 cagcagctca aatccctgca ggtgacatcc gatgagcgaa aaagctgcca gcaggccgca 1040821 gagatggcat tgcgcatcag acaaaccgag gaacaaatca aaaaagagaa aaaacgaagt 1040881 gaagaattga acctcgtgct gcagaagatg aatgaagaga agaatacact cgttcaaaag 1040941 acggaagcgg aagaaaacaa catcattcag gcatatgagg cagttcaaac tgtgtaccat 1041001 ttggtgtgcg aaacggaacg ctcattaaca cgtatgacgg aagaggctag aaagagtcaa 1041061 cacacgcttc acttacagcg tgaaaaagca agggtggcac tgctgacaaa agagttagcc 1041121 caaaagctga ctgccggaaa gccttgcccg gtatgcggtt caaccgatca tgatccatct 1041181 gcctcggtac atgaaacgta tgaagccgac agccatcttg aagaggacat caaacggaca 1041241 gatgtgttat tgacggaagc tgcagctctc agccaggaga ttctttcagc caaaattatg 1041301 cttgaagaac agtccgcgcg ctttattgaa cagtgtccgt ttttgcagac aattcaagca 1041361 cagaaccttg aagcggcagc ttccttcgaa catcagccgg tgtatgaagc atttgaaact 1041421 gccaaatttg aatggaaacg aatcaagcag gacattcttt ctgttaagac acgaatggca 1041481 caaatgattg gcgcctatca ggagtcttta aaaaaggccg agcagcttaa tgaaaaaatc 1041541 ggttttgaaa aaagagaagc cgaccgtatt gaaagcatca tcagtgagct tcaatcctca 1041601 atggacagca gtctgaacat gtttaaagaa gcatttcaga atcaatctgt ggacgaagca 1041661 gaaaaatggc agcaagccat tgaagaaaag gaccgggctg cagaagaatg tgaaaaacga 1041721 attgagaaga gtatcgcgtt tcttgctgag catgaagcac aaaaggaaaa actgcgggaa 1041781 tcgggacacc ggcttgagcg ggaaaagctg gagcttcatt atgcggctga acgcatcaag 1041841 agcgtgatag ctgattatga gcacgaactc ggagattatg caaaaggaga ttcgattcaa 1041901 atcaaactcc gctctgtcca gcaggatcta aagctgttaa aggaaaaaga acaatcttta 1041961 tatgaagaac tgcaaagcgc ccaaatgaag ctcaaccaag cgaaaagccg cgcttctgca 1042021 agcgagctca ctcttcaaga ggcgaagggc agattggaaa aagcaaaagc tgcttggctt 1042081 gagcatacaa aaaacacctc cattacccgg actgaggagg ttgaacaaag tctcatccca 1042141 gctgatgaac ttgaaaagat gaaaaccggc atagaccagt ttatggataa actgaagcaa 1042201 aatgctgcaa acttaaaacg agtagcagag atacttgccg gcagagcatt atcagagagc 1042261 gaatggaacg aaaccgttgc agcattacaa gaagctgagg acgcatttgg cgctgctata 1042321 gaggaaaaag gcgcggccgc aaaagcactg gctgtcattc gcgaccatca taaacggttt 1042381 aatgaaattg aagctgaact gaaaaaatgg cagatgcata tcgacaggct ggacaagctg 1042441 caagctgtgt ttaaaggcaa taccttcgtc gaatttttag ctgaggagca gcttgaaagc 1042501 gttgcgaggg acgcctcagc aagactcagt atgctgacaa gacagcgcta tgccatcgaa 1042561 gtagattctg agggcggctt cgtgatgcgg gatgacgcga atggaggcgt acgacgcccg 1042621 gtttccagtt tgtctggagg agagaccttc ctcacctcgc tttcacttgc tcttgcgctg 1042681 tctgcgcaga ttcagcttcg gggggaatac ccgctgcagt tctttttctt agatgaaggc 1042741 ttcggcacac tggatcaaga tctgcttgat acggttgtaa cggccttgga aaaacttcag 1042801 tcagacaacc tggctgtcgg tgtcatcagc catgtgcagg aactgcgtgc acggcttccg 1042861 aaaaagctga tcgtccatcc ggctgaaccg agcggccgcg gtacgcgggt atcacttgag 1042921 ttgatgtaag ggaggagcgg atatggcaaa gcagattgcc ggaatatgtg agctgtgcgg 1042981 ccggagcgat gtccagctga cagagcatca tcttacaccg aaagaggaag gcggaacgtt 1043041 tttgccgaca gcgatgctct gtattccttg tcataaacag attcatgcct tatataccaa 1043101 tcaagagctc gctgtacgtt taaatggaat ggctgaactc agaagcgatc cagagcttgc 1043161 ccggtttgtc aaatggatca gaaaacagcc gcctgagaag ctgatcaaaa ctaagaaatc 1043221 aaatgaacga aaaaagaaaa aatgactaaa aagcagccct ctctttgcag agcggctgct 1043281 tttatccgtt tccaaccata tccggaagca aaagttgttg ttgaaaagta accaaaaagc 1043341 ggtgctcgat gcaccgcttt tttatttgcg cccccgttgg actgctgtgt acataatgga 1043401 tcgctttccg tttgaagccg tccattcaaa acggtctcct gtcccttcgc tgctgtagtt 1043461 gtagtgatgc tgcatcgcgc attgtgcggt gtcatttgaa aagtgataaa aggacacacc 1043521 ctgccccgcc gaagtattcg aaaagactcc tttattataa gaaaagacgc aatcgaatac 1043581 cgataagccg aagctgtgca agtgctgcag aaatgcgaga aaggtttcgt cgtcaagcga 1043641 atccaaaagc gccatgagcg gccgcttgac tgatttctca tagcggatgc gttctccgcc 1043701 ggaaagggag atgttttctg caccgcatgc caaaaccaac ttgtcctgaa agccggcttg 1043761 ctcccacttt cctttatgat ggatccagat tgggctgtgt tggagactgt ccgccagcag 1043821 tatatcgcct tcaccgtttt cgattaagca gatgccgtct tcaatgagga tggtgccgta 1043881 ttcccacttt cgttcctctg tatataacaa ttgtttccgt ttcatccatg ctgtctcctt 1043941 tttcttcatt cctctctttt ctttccaatt caagcctgtc ccatacaact cttttatgga 1044001 caaatcaact atctgcctat agatgcataa acttactaag gtgctgaaag aaacgaaatt 1044061 gttacgaaag aaacgggatt ggagctgatg tcacatgtgt ggaattacgg gttgggtcga 1044121 ttttaaaaag cagctcgtcc aggaaaaaca aacgatggac agaatgacag acactctttc 1044181 caaacgaggg cctgatgatt caaacgtttg gggggagcac catgttttat tcggacataa 1044241 aagacttgcg gttgttgata ttgaaggcgg acgccagccg atggcgtgta cctataaagg 1044301 cgatacgtac accattattt acaatggcga gctttataac acggaagatt tgcgcaaaga 1044361 attgcgggcg cggggccatc aattcgagcg tacgtcagat accgaggtgc ttctgcacag 1044421 ctacatcgag tggcaggaag actgtgtcga ccatctcaat ggcatattcg ctttcgctgt 1044481 gtgggatgaa aagcgtaatc tgttgtttgc cgcgagagac cgtctcggtg taaagccgtt 1044541 tttttacacg aaggaaggct cttcatttct cttcgggtcg gaaatcaaag caatcctcgc 1044601 gcaccctgat ataaaagcgc gagtggacag aacgggactt tctgaaattt tcggtcttgg 1044661 accgtccaga accccgggca ctggcatatt taaaggcata aaagaaatcc gcccggctca 1044721 cgcgctgaca ttttccaaag acggacttaa tatttggcgt tattggaatg ttgaaagcga 1044781 aaaacatacg gacagttttg atgacacggt tgccaatgtc agatcgttat ttcaggacgc 1044841 ggtgacgcgg cagcttgtgt cggatgtgcc tgtttgcaca ttcctatcag gcggtctgga 1044901 ctcaagcgcg attacagcga ttgcggcggg ccattttgaa aaggaaggaa aagcaccgct 1044961 tcatacttat tcgattgatt acgaagagaa cgataaatat tttcaagcaa gcgcttttca 1045021 gccgaatgat gacggaccat ggattgaaaa aatgacagag gctttcggca caacgcacca 1045081 caaatgcgtc atcagccaaa aagacctcgt tgatcatttg gaggaagctg tactggtcaa 1045141 agacttgccg ggaatggcag atgtcgactc atccctgctg tggttttgcc gggaaatcaa 1045201 aaaggacttt gtcgtcagcc tatcgggaga atgcgcggat gagattttcg gcgggtaccc 1045261 gtggttccat acggcagatg ttgagtctgg ctttccatgg atgagatcaa cggaggagcg 1045321 gatcaagctg ctttctgact catggcagaa aaaattgaat ctgaaagaat acgtaaatgc 1045381 caaatatgaa gaaaccttgg cagaaacgcc attattagac ggagaaacgg gtgtggataa 1045441 agcaagaaga cagctgttct atttaaatat gctttggttt atgacgaacc ttttggatcg 1045501 gaaggatcgc atgagcatgg gggcgagcct ggaagtgcgg gtgccgttcg ccgatcaccg 1045561 gcttgtggaa tatgtttgga atattccgtg ggaaatgaaa atgcatgata atcgggaaaa 1045621 aggcattttg cgcaaagcgc ttgagggcat tttgcctgat gacattttgt atcgcaaaaa 1045681 aagcccatat ccgaaaacac atcatccgga atatacaaaa ggcgtcagcg agtggctgaa 1045741 aacgatcaga agccaaaagg actccgtgct ccatacctta ctggacagaa aacaattaga 1045801 tcagctttta gaaacggaag gctcctcctt caaggtcccg tggttcgggc agctcatgaa 1045861 ggggcctcag ctgatcgccc atcttgctca aattcataca tggtttgaag cgtatcgcat 1045921 tgatattgac gagaggtagg ttcaatacaa atgtgattaa aagccagaga tgtatagatt 1045981 taaataagaa ggatagatga gcagggaaat atatgctcta tctatccttt tttgtacaac 1046041 agcactatcg aattgccccc gcattccttc aataagaatg aataggtttt aatgttctgc 1046101 cgataaaact agctgatacc gggcttaact ttaattccct agcccataca gaaagttgac 1046161 caatatggtg aatttcgtga gcgatgatat ggtgtaatat ttcatctcgc gtatataaaa 1046221 cacctgtctc ccaaggaacg cttacaagtt catcttttat ttgatctgaa tgtgtttgta 1046281 aaacatcaat tatttcagtt cggaatgtat ttgagagaga tttcacttta ttgagtgttt 1046341 gataatcagc gaactgaaca gcgatatctt cttttccttg gatagcacga atccaactat 1046401 attccacatc aataatatga aaaagggtat ataaaatatt ctctactccg ccaagacgat 1046461 ttttaagtaa ttcttcagtg gttagttgat gacaccaagt aaaccattga tctctaacct 1046521 gccagttata ttcaaaaaat ttcatcacta aactcactcc aatactatca tgtatcataa 1046581 caattagccc ttttttccgt gattcctcta ttaatgaagt gatgattgag aaatgtttac 1046641 attctacctg ttgtatggca ttaaaaataa taatgcatat ctcgtcgatg atgctgtgcg 1046701 tcttgttact tttacaaagt aagaatcggc attttcttca tatacaatta ggaaaaaaca 1046761 tactagactt gaagaagcag tgatacatag gagtgagaaa atgaaagaga taaaagaagc 1046821 ttaccagcaa tgcggacaga ttgttggcga atacgcgcca gcctgtttca aagcattatc 1046881 atatctcccg ctaaagcaaa gacaagcctc ttgggcagta ttgtcgtttt gccacacggc 1046941 ggccagtgca gacgaaaagg tattgcccgc atttgaagct aaagctgatc atgtttacca 1047001 aaggacaaat aacggtaaac aacatctatg gaaggctttt gatcatgcgt atcggacctt 1047061 tacattggaa agcgaacctt ttcgggagtt tattgccgca caaaaagaag acgccaagcc 1047121 gtatgatgac cttgatgaac tgctcatgta cgcatatcgg acgggcggtg ctgccggatt 1047181 gatgctgctg ccgatactga cacgccgaaa acaagatcag ctcaaacaag cagccgtctc 1047241 tctcggcttg gccatacagc tggttcgctt cttaagtgat cttggcacag atcagcaaaa 1047301 aaaccgcatt ccccgtcagg taatgcagca attcggctat acagaggctg atctccaaaa 1047361 aggcaccgta aataaagcgt tcacaatgac gtgggagtat atcgcttttg aagcagaagc 1047421 ctaccttgaa gagtgtcagg atgccttgcc gctatttccg cagtattctc aaaaaacggt 1047481 gaaagccgct cttcatttgc accgggctgt tttagaaaaa atccgggcga agcagcacga 1047541 tgtatttcaa tatcacttcg ctctcacaga gaccgaagtg aagcagattc tgtctgatat 1047601 ctaaaaaaca cccggccttg attgagccgg gtgttacgcc ataccttttt gaatccagat 1047661 acgtgagcgc catcttctgt acattaagat tccccggacc cattcatccg cgataaaaga 1047721 aatccaaatg ccggcaagac cgaaaccgag gtggatgccg aaaagataag caagcgggag 1047781 gccaatgccc cacattgaaa tcattgccat gtaaaccggg aatttcgcat cccccgcggc 1047841 ccgcagagag ttaatgataa tgacattaaa cgagcggcct ggttcaagga taatggtcat 1047901 ggcaatcaat aggcttgcag ttgctataat gtcagggctt tgtgtgaaga gtccgatcag 1047961 gtcttttgaa aagatcgtca tcaaaacaga ggtagccgca gcaattccga gtgcccaata 1048021 taagctcttc atgcagcgct cataagcggc atcaaattgt ttgccgccga tataacggcc 1048081 gattaagatt tgtgtaccct ggctgatcgc agtgccgaac agcaaaataa acatcgtaat 1048141 attttgcgta tacacttttg ttgtcaacgc ctgcgcgccc atgatggcga taaaatacgt 1048201 gactatcatt tgcgacaggt tgtatgaaag ctgctctccc gcagaaggaa tgccgatttt 1048261 cagcagcttg cgcaaatgct ctttatgcat atgaaagact tttttcagcg acatcttcag 1048321 ctggatgcgt ttgttgacaa tcacaatcat cgcgattaat ccgatgacgc gggcgataga 1048381 tgtggacatg gccacaccgg caacaccgag aacaggaaag ccgaacaaac cgaaaatcac 1048441 aacaaagttt ccggcaatgt ttaaaatgtt catgccgata gtgacaaaca ttgtatcttt 1048501 tgtgtagccg tagcttttta agatcgcgct gaatgtcatg attaaagcct gaataaagga 1048561 cagacctccg acaacttgta aaaagacttt cgcatcaggc atcagtgcgt ctgataatcc 1048621 catcatatga agcagaggga cagccgcgaa aaagacgacg gcgctgatgg ccaggctgat 1048681 gaagaagttg gcgccgattg acacataagc gacttccatg gcttctttct tttgccgtga 1048741 gcctagaaat tgtgaaatga taacggtcgt tcctgttgcg ataaagctga acatcacgat 1048801 aattaaattt aaaatctggt tgctgacgcc gactgctgcc acgctgttat ccgagtattg 1048861 gctgagcatc agtgtatcgg cattacccat aaacatatat aatgagacct caataaagat 1048921 cggccaagta agcgaaaata atgagaacgt tttgtcagcg ggttttttca aagcagttga 1048981 tttgaagaca gcttgtttca tcgtgtctaa cccctttcgt aaataaaatc aacgttttaa 1049041 agtgtacctc catttcctta taataaaaag ggatagaaac gatacttctt gtaaaaatcc 1049101 gacttaaaaa ggaggatgat tcaaatgcct cgcatcctgt ttacagtccc gccttttccg 1049161 gtatttatcg cagctgggga aggggttttt aaaaaaggag aaacccatgt gaaacgtgta 1049221 ttctccgtgt ttgatctgat atatgtcaaa cagggaacgt tatatataac ggaaaatgaa 1049281 acatcgtttt ctgttgaagg cggcgagtac atcttgcttt ctcccggtct tgaacactac 1049341 gggacgaagg gcagtgatga agcaacctcc tactattggc ttcacttcga tgaacatcga 1049401 tatgaattta cggcaaaggg aggcagcaac tggtctgagc ttcagcagga aaaagggagc 1049461 ttcgaagagc tggcccgcta cggattggcc ttgccgagaa aaggcaaggt gcagcgcccg 1049521 cagtttatgg cgcagcagtt tgaaaagctg atcgattact ccgcggaaaa ctctgatttg 1049581 ccgctcagaa agcaaatttt atttgaggag ctgatgctgc atcttcaaaa agaagcgttc 1049641 caaataccgt ctgcgaaaga gcgggtagcc tgggaggcgg cccggtattt acaggagcac 1049701 tataaggaaa agacgacaat caaggatctg tcgctcgccc ttcactatca tcaggattat 1049761 gtgagccgct gcatgcagca ggtgctcggc gtaactccgg cacaatacac gaaccgggtg 1049821 agaatgacgg aagcgaagcg tcttttatcc tctacaaatg ataaaatggg cgttattgcg 1049881 gaaacggtcg gaatggaaga tccgacatac ttttcaaaac tctttaagca gatagaaggc 1049941 atttcaccaa ttgaataccg gaaaattgtc agccggaaag ttcaataacc agacgaggga 1050001 tgaacatgaa aacaacaatt tacgatgtgg caaaggcggc gggtgtttcg atcacaactg 1050061 tgtcccgtgt gataaacaat acggggagaa tcagcgataa aacacggcag aaggtcatga 1050121 atgtcatgaa tgaaatggca tacacgccca atgtccacgc cgcggcgtta acgggaaaac 1050181 gaacgaatat gatcgctctc gtggcgcctg atatttcaaa tccgttttac ggcgaactgg 1050241 ccaaaagcat tgaggaaaga gcggatgagc tcggttttca aatgttgatt tgcagcaccg 1050301 attacgatcc gaaaaaagaa acaaagtatt tttctgtgct gaaacagaaa aaggtggatg 1050361 gcattatttt tgcaacaggg attgaaagcc atgacagtat gtctgctttg gaggaaatcg 1050421 ccagtgaaca aattccgatt gccatgattt ctcaggataa gccgcttctt ccgatggata 1050481 ttgttgtgat agacgacgtt cgtggcggat atgaggctgc caagcatctt ctgtcactcg 1050541 gccacacgaa catcgcctgc attatcggag acgggtcaac gacaggcgaa aaaaatagaa 1050601 tcaaaggctt ccgtcaggcg atggaggaag cgggcgtgcc cattgatgaa tcacttatca 1050661 tccagacgcg gttttccttg gaaagcggca aggaagaagc gggaaaattg ctcgacagaa 1050721 atgctccgac tgctattttt gccttcaacg acgtattggc ttgtgccgcc atacaagctg 1050781 cgagaataag aggcataaaa gtgccggatg atctttctat cattggtttt gataatacga 1050841 tactcgcaga aatggcggct ccgcccctga caaccgtagc ccagccgata aaagagatgg 1050901 ggcggagcgt catcgaactg ctggcagaag caatagaggg aaaacgaaag gcgaaacaaa 1050961 aaatagtgct cccgcctgag cttgtagtca gacattctac atcaccgctc aacacatgag 1051021 cccgctaatg agcgggtttt ttcattatga cagttgaagc caaaaaaaca tattgcgtgt 1051081 aaaccaaagg cggtgtaaaa tataaccatc ttttgagaaa gcgcttgcgc aaaatggcag 1051141 agcggataga accgctgttt ttttagctgt taagagaaaa cgctttctca aagcgagccc 1051201 gaaatgagat aaaggagagg atgggacgtg gaacatcaag taagatgtgc agtattggga 1051261 ttaggaaggc tcggttatta tcatgcgaaa aatctcgtca ccagtgtgcc gggggcaaag 1051321 ctggtttgtg tcggtgatcc gttaaaaggg agagcggagc aggttgccag agaactcggt 1051381 atcgaaaaat ggtcagagga cccgtatgaa gtgttagaag atcccggcat tgatgctgtc 1051441 attatcgtaa cgccgacaag cacacatggt gatatgatca tcaaagcagc cgagaacggc 1051501 aaacagatct ttgttgaaaa accgctgaca ttaagccttg aggaatcaaa agcagcttct 1051561 gaaaaagtta aggagacagg tgtcatctgc caagtcggct ttatgagacg gttcgatccc 1051621 gcatacgcag atgccaaacg gcggatcgac gctggagaaa tcggcaaacc tatctattat 1051681 aaaggcttta cgcgcgacca aggcgcgcct cccgcagaat ttatcaaaca cagcggtgga 1051741 atttttatcg actgttccat ccatgactat gatattgccc gttatttgct aggggcggaa 1051801 atcacttctg tttcaggaca cggcaggatt ctgaacaatc cgtttatgga gcagtatggc 1051861 gatgtggatc aggcgctgac gtatattgaa tttgactcgg gcgcagcggg ggacgtcgag 1051921 gcaagcagaa cctctccata cggacatgac atccgggcgg aggtgatcgg gacagagggc 1051981 agtattttca tagggacatt gagacatcaa catgtgacca tcctatcggc taaagggagc 1052041 agttttgata tcattccaga ctttcaaact cgttttcatg aagcctactg cttggagctt 1052101 cagcatttcg ccgagtgtgt ccggaatgga aaaacaccga ttgtgactga tattgatgcg 1052161 acgatcaatt tagaagtggg tatcgccgca accaattcct ttcgaaacgg catgccggta 1052221 cagctagatg tgaagcgcgc ttatacaggt atgtaaaagc taagtatgtt gcatttgagg 1052281 ctttccgcaa aaaaagcaag ggcattttag cccttgcttt ctcttttctc atataaatag 1052341 tacatataat cagtaggtac gcctgaatgg tccagctgtc tcagcatggc ggttacgttc 1052401 cctctgtggt aagtgccgtg attgacgaca tgcaggatgg tgtctgcata ggttgattcc 1052461 agtgtaccta gtttcggatg ctgcattgtg aaggtctgtt ctaagtccgt ctggcggctg 1052521 aagaaatcat gatactgtga ctccagctcg gcagcgtgct gtttaatcgc tgccatatta 1052581 ccttgcgcgg actgtaattt gcctgcgctg tctataatct cttggtaggc cactcccgaa 1052641 agaacattca gccaaatgta gtcagccctg cacatatgaa gcagcacgtc gctgacagaa 1052701 ggaaatacgc tctttacttc ttgataggca gtttcctccg gcaggttttc gatatgggta 1052761 aatattttct tgtttgccca agaatgatag tcataaaact gttttgcatc agtcatcagc 1052821 atgccccctt ttctaagaaa ttcgtttttt tcatctgttt ctccttcaat tgcaaaagag 1052881 tgacacccca aaatatcctg ccgctgccca cattaccgct gcagagcatt tgtttacgat 1052941 cagcataagc ctgccgctcg tatctatcgt ctgaaacaac cggcccgcta ttgcaaggct 1053001 gatgaaccaa atccaagaca cagcgatgca ggcggccata aagagccatt tctcaagccc 1053061 cgaatattga agagagctcg tgccgatgac gccgatcgtg tccagaatgg catgcgggtt 1053121 taaaagagaa acagcggccg caaacgcagc ttgctttttt ggtgtgaacg tatgtttctc 1053181 attttggctt gtgttcggac ggatgttcca agtcacccag cccatataaa gcaaaaataa 1053241 aaatccgccg gccatcatga ctgtctcaaa cacaggcagc tcctgcacaa tgacagacac 1053301 gcccgcaacg gctaatacaa ttaacaaggt atcgcagact gaagcactga tgacagctgg 1053361 gagagcccgc caaatatgct tttgcaacgc gccttgctga aaaataaaca cattctgcac 1053421 tcccagcggc aaaattaagc caaacgcgag cacaattccg tgaatgattg cattcatgct 1053481 gaaaaagctc ctttcacatt ttttttcaat cataagagag attgtcacta aagtctccag 1053541 ccatttggtt gggttaggaa ccagccaaat gtataatgtg taaaaaaggg gggcatgacc 1053601 ttgtcgcaat ggcagccaag ccgaaagtcg gatgttccgc tgcatcggca gatcgaacaa 1053661 tatatgaaag acaagattct tcacggagag tgggctgtag ggacgaaaat cccctcacag 1053721 agaacgctgg ccgacatgtt tcaagtcaac cgcagcacag tcacagcagc catagatgaa 1053781 ctcacgtctc aaggcttgtt agagggaaga aaaggcggcg gtacgaaggt tgtaaacagt 1053841 acttggagcg tgctgacggc tgagcctccg cttgattgga gcgattacgt ccgttcgggc 1053901 attcatcgcg ccaattcttc catcattcaa gctattaatc agaacgaacc aagagcggat 1053961 atcatcagat taggaactgg agaactttca ccggatcttg tgcctgctga cacaattgga 1054021 cggatgtttc agcaaatcaa tccgggcgtc ctgtctttag gatatgagca gccgaaagga 1054081 aaccgtcagc tgcgggaggc agtggccgac catttaaaag gaaagaagat ccatgtgtca 1054141 ccgtctgcaa ttttaattgt gtccggtgca cttcaggcac ttcagctcat ctcaattgga 1054201 cttttaaaac gagattctgt cattttgacg gagaagccgt cctaccttca atccttgcat 1054261 gtatttcaat cagctgggat gcggcttcgc ggcttgccga tggatgatga aggggtcaaa 1054321 gcggggcttg tttcttctaa tcgaaaacaa tatggaggac agctgcttta cacgattccg 1054381 tcgtttcata atccgacagg cacagtcatg tcagagcagc gaaggaaaga gatcatcagc 1054441 ctgtcaaaaa aagagcagat gcccatcatt gaggatgatg cgtacggtga tttatggttt 1054501 gaagaaaaac cgccgcagcc gttgaaagca atggatcatg agggcaatat tctgtatctg 1054561 ggcgcgtttt caaaaacggt tagccccggt ctgcgaatcg gctggcttgc cggtccggag 1054621 ccggttattg aaaggctggc ggacattaaa atgcagacag actacggatc aagcggcctg 1054681 tcccagtggg cggctgccga gtggctgtca cagggatatt atgaagagca tctgacttgg 1054741 gtacgcagga agcttaaaga aaggagagac gccgccgttc attttctcga gcggtatgcc 1054801 ggggacattg ccacgtggcg gattcccgca ggcggctttt atatttgggt gacatttcac 1054861 aaaaacctgc ctgtcagccg tttcttttat gaattgctga aacggcaggt gcttgtgaat 1054921 cccggctata tttatgacgg tgaagaccga aacagcatca ggctgtcata ttcctatgca 1054981 tctcttggag atttggaaac tggcattaaa gcggcagctg aaacagcacg ccgcctgatg 1055041 atgtcctagg ctttggttat acgatgacag ctcccagtgc cctggcgaag gcaatcgcgt 1055101 gctcaggtgc gattttgcag cctttcaatt tgtcgaggga gacatgaagc tgttcaaaac 1055161 ggcacgtgct gatgtccatg ttttgaaggg acgtgccggt aaagctggcg ccttccaatt 1055221 cgcatccgtc aaagtgtgtc tgctggagca ccgtatcgct gcattcactt tgcataagag 1055281 cacagtgatc aaatcgaact tgtttcatat ttgagtacga aaatgagctg aaatgtccgt 1055341 ggcattcctc gaatgaaaca ttccgcagcg ttgcttccgc cacattcatt ccaaccattt 1055401 ttgactgctt aactgaagtt ctgtgaatga cagccccgct gaaatcggcg tttgataaat 1055461 cgcatttttc aaagatcaca tcggtcagtt caatatgccg aaaagacaca tcgataaaga 1055521 cgacatttct gaataccgtt ttttcaacac atagtctttc gatatcttcg ccgcagatgg 1055581 tgcaatcttc aaacaaatgc atgctgatta catcatcctg tgtcacggca tcatgaaaat 1055641 ctgcggtttg caggttttcc ggtatgttcg gtttttgaat tgcgatttta ttcatgtgat 1055701 gacatccttt gctgcccgaa aaacagaggc ttccgggttc aatttaatag atcgttaagg 1055761 aaattgatac atatagtaaa tcgtgaagag ccttttcttg gtacagcagc ccgcttgttt 1055821 tgtaagcata aatggaaagc ttcctatacg tcaaggcgtt tacaggccga aaaagccaaa 1055881 gggaacagga ggaatgcgga atggggcatt acatcaaaac cgaggagcat gtgacactgt 1055941 ttgtagagga tatcggacat ggaaggccga tcatcttttt gcacgggtgg ccgttgaatc 1056001 ataagatgtt tgaatatcaa atgaatgagc ttccgaaaag gggatttcgt tttatcggcg 1056061 ttgatttgcg gggatatggg caatctgacc gcccttggga aggctacgat tatgacacga 1056121 tggccgatga tgtgaaagca gtcatttata cgctgcagct tgagaatgcg attcttgccg 1056181 gtttttcaat gggcggcgca attgcaatcc gttatatggc aaggcatgaa ggagccgatg 1056241 ttgataagct gattttactg tctgcggcgg cccccgcgtt tacaaaacgc ccgggttatc 1056301 cgtacgggat gaggaagcag gatattgacg atatgattga attgttcaaa gctgatcggc 1056361 ccaaaacact ggctgattta gggaaacagt tttttgagaa aaaagtgtct ccagagctta 1056421 ggcagtggtt tctcaatctg atgctggagg cttcctccta cgggacgatc cactcgggca 1056481 tcgcattaag agacgaagat ctcagaaagg aacttgctgc aatcaaggtg ccgacgctga 1056541 tcctgcacgg gagaaaggat agaattgcgc cgtttgattt tgcgaaagaa ttgaagcgcg 1056601 gcatcaaaca gtcggaattg gttccgtttg caaacagcgg gcacggagca ttttatgagg 1056661 aaaaagagaa gatcaacagt ttgattgcgc agttctccaa ctcataagaa aaaacccgac 1056721 attgatcggg ttttttatat aattcctctg ttttgcagtg cgttaatgat gagatcagct 1056781 ccatcggaaa tagaggtctg gtcagactca atgatgaaat cgggtgaaag cggcgcttca 1056841 tacggagaat cgatcccggt gaaatgtttg atctctccgt ttcgcgcttt tttataaagc 1056901 ccttttggat cgcgctgttc acaaacatgc agcgggcact tcacataaat ttcgaagaac 1056961 tcacctttag gaaagagcgc tctaaccatg tcccgatcct ctctgaatgg agaaataaaa 1057021 gccgttaaaa tcatttgccc gctgtcgaca aacagcttcg ccacttctcc gatccggcgg 1057081 atgttttcaa tcctgtcacc agtctgaaat ccaagatctt tgtttaagcc gtggcggata 1057141 ttatcaccgt caagcacgta gctctgaatg cccttgcggt aaagcttttc atcgacagca 1057201 ttggccagca ccgattttcc ggagccggac aaacctgtaa accaaaggac gcagcttttg 1057261 tgtccgttta aggactgtct gtcagacttt gagatggcag cgggatgcca aatgatgttc 1057321 ggattgtgtg tcattgcaat tccccgctgt tttgcttgat ggcaacaggc tgttggtgaa 1057381 gtcccttgat cagcacggct gcgacctcag gccggctgaa ttctttaggc ggctttttgc 1057441 cttggcggag aagctctctc acttttgtgc ctgataagtg gatgtggtct ctcgggctgt 1057501 gcggacatgt tttggaggtg cccatgtttc cgcattttcg gcaataaaag ctgtgctcaa 1057561 aaaacagcgg cttgatgccc agctcttcct ctgtgaatga ttgaaaaata ttttgggcgt 1057621 cgtatgttcc atagtagctg ccgacacccg cgtgatcacg gcctacaata aaatgggtac 1057681 agccgtaatt ttttcggacg agcgcatgga aaatcgcttc ccgcggacct gcataacgca 1057741 tggcggcagg gaaaaccgat aacatgacac gatcctttgg ataatagtga ttaagcaaag 1057801 cctggtagct ctccattctg atatcgctgg ggatatcgtc tgactttgtt tctccgacaa 1057861 gtgggtgaag cagcagaccg tcgaccgttt ctaacgctgt tttttgaatg tattcatgcg 1057921 ctctgtgaac agggttcctg gtttgaaagc cgacaatcgt cttccagccg agtttttgaa 1057981 aggccgctct tgtttcagcg ggcgttgcat aaaactgttc gaaagatttg tcaggcaggc 1058041 tgctgaccgt gataggccct ccgatatagt aatccgggcg cgccagcaat ttttttacgc 1058101 ctgggtgggc aggatcgttt gttttaaaaa cagacagtgc ttcttgtgtt ttatcaggct 1058161 ggtatatatc ggtgactgtg atcatgccgt aggtaacacc gtctttcaca agcttgacgt 1058221 gatctccggc agacagctgt cttgctgttt tttctccgac aggcagcgta atcggcaggc 1058281 tccacggcaa gccgtttgcc agcctcatct ctttcacaac ggaatgataa tctttttctc 1058341 ccaaaaaacc tgttaacggg ctgtagccgc cgatcgcaat aagctccaga tcactcagtg 1058401 caagctgatc cagctctgct tggcacgcgc acccttcaaa atggcatgcg ggatcacagc 1058461 ggttgattaa tacccctccg tggggttcgt ttccattcaa cgtgttcaac ctccatttat 1058521 acgtttcctt gttttctttt ctgcacttaa tgaaagtttg acatcagcgc cttaacatca 1058581 tttcgattct cacatcaaga acctgccatc cgctattctt gatgcaggcc gcattctgtt 1058641 ttctcccgtc cggcccatct tccagccctc tcatcgttcg ggtccgggga aggcagtgta 1058701 cacatttcac agcctatgct cggataatgt tgatcgtgca gtttgttata aggcaaattg 1058761 tgcaggcgga tgtacgtcca aacgtcatcc catgtccagt ggataagcgg gcaaattttg 1058821 atgagctcaa acttctggtc caggtttacg tattgaatat gctttctcgt tggtgactga 1058881 tcccggcgca gtcctgaaat ccaagctgtc atgccggaca ggtgcttttt gagcggttcg 1058941 attttccgca attggcagca gaggttcggg ttatgcttcc acagctctcc gccgtacttc 1059001 gtcccctgtt ctgttaagct cagctcgggt tcgagcatct ggattgcaaa tcccggatat 1059061 cgttctttga cggtctcgat cagctcatat gtttcctgaa aatgaagccc ggtatccaaa 1059121 aagatgatgt gtgcgttttt gttgattttt gatattaagt cgagaagcac cattccttct 1059181 gcgccaaagc tgcaggcgta cacaatcttt tctccgtacg ttcggtaagc ccatttcaac 1059241 acatcgagct catcgatcaa ttgatccgtt atctgtttgg acagcatgtc gttccaagtg 1059301 tcatatgtga tggtttcgtt caatgttttc cccccgtttg catctgcttt ttttatctat 1059361 tgatcgagtt ataggcagac tattcatttt ttgcataaag gttcaggttt taggtgccgc 1059421 gcccgcctaa aatgaggtgc ggaaccatta agagcccggc tgaatatgct ttttagcaaa 1059481 atggttttat gcccaaggag aggtagtatg ccgattgcca tttatcaggg gcatcatcat 1059541 tcgcttgccc cggcggacat taacatcgtc attgatgtca tcagagcctt tacggtcgcc 1059601 cattatgcgt ttatcggcgg ggcgaaagag attttgttgg tccggacagc tgatgaagcc 1059661 tttgcgctga aagacaccta tccggattat gttttgacgg gagaggaaaa gggggtcggt 1059721 atcagcggat ttgatttaga taattctcca aaacgtatgg ctgggcagaa tatgacggat 1059781 aaaagcctga tccagaaaac aacaaacggc gtcacagcag cattgggggc gctgaacgca 1059841 aagcatctgt tcgtaactgg attttccaat gccaaaacaa cggcacagca tgtgaaaaag 1059901 ctcgtcgcaa acgattgtgt cataaacata gtggcttccc atccatccgg tgatgacgat 1059961 atggcatgtg cggagtatat caaaggcatc attgaaggga caaatgtggt aacggctgcg 1060021 gaggcgattg aaagaataaa aggctcttct gttgcggaga agttttttga ctgccgccag 1060081 ccattgtttg attcggaaga catcgtttac tgtacaaaag aactgacggg cgatttcgtg 1060141 atgaaagtga aacaagatgg agaagttcca acgatagaga gggtcataat atgaatgatt 1060201 tttcactaga attgccagtg agaacaaaca agccgagaga aaccgggcag tccattttaa 1060261 ttgataacgg ctatcccttg caatttttca aagatgcgat agccggagcg tccgactata 1060321 ttgattttgt gaaattcggc tggggcacat cattacttac gaaagatctt gaagaaaaaa 1060381 tcagcacact gaaagaacat gacattacat ttttctttgg cggcacactg tttgaaaagt 1060441 acgtaagcca gaaaaaagtg aatgaatttc atcggtactg cacctatttc ggctgtgaat 1060501 atattgagat ttcaaacggt acgctcccga tgacaaataa agagaaagcg gcttacattg 1060561 ccgatttttc tgatgaattt cttgtgctca gtgaggtggg cagcaaggat gcggaattag 1060621 caagccggca aagctctgag gaatggcttg aatatatcgt tgaggatatg gaagcgggcg 1060681 cggaaaaagt gattacagaa gccagagaaa gcggaacggg agggatctgt tccagcagcg 1060741 gcgatgtcag gtttcaaatt gttgacgaca tcatttcctc ggatattgat atcaacaggc 1060801 tgatttttga agcgcctaac aaaacgcttc agcaagggtt tattcaaaaa atcgggccga 1060861 atgtgaatct tgccaatatt ccatttcatg atgccatcgc gttggaaacg ctgcgtttag 1060921 ggctaagatc cgataccttt tttctgtaaa atagcggctg cggggctctc gtcgtgaaga 1060981 gagcctctgc ctattatttt ttatggcggt acataggcgt gagataggga agtgaggtca 1061041 ggcggatgtt gtagatgaag tcgatgactc ttgtcgatat cacctggcat atgagggctt 1061101 gaatgacgat gccccagtca ataatagacg cggtgaccat aaaaatgatg caattcatga 1061161 tgagcaggat cgttccagga ttcccgccgc ggtagataga aatcatcaga gcaagggctc 1061221 cgaatcctcc gttcgaaatt ttatatttgt ataaaagtcc gattccgagt cccaataaca 1061281 ctgcgccgct tgccagatca agccacaggt tagatgtgat atcaggaaaa actgcatcaa 1061341 agatcaatac cgagacagag gtgacggtga tagaagcgag ggtgccggtg aatgttctca 1061401 tctccagcca ttttaaagcg gtaaaaagca ttgatacatt cacagcccac actgaaaatc 1061461 cgtgggggat ttgaaacaga taatgcaata gcaccgcaat acctgctgca ccgcctgtcg 1061521 gaatatcatg cggaaataaa aacaaggaca tgccgagtcc ttgtagtacg ccgcctacga 1061581 caatcataaa cgtaagtttt gctttcatca gcagttcagc cattaagtca tttgctcctt 1061641 tatgaaaaga cttgtccgct gttttcattt tatgaggctg tccattattt atgtctcaaa 1061701 ataaagaaat ggcccagctt aataggctga gccatcccac ttgtagcgat tgacgatctc 1061761 catattgatc tctgtgccaa tgccttttcc tttcgggatg tggaccattc cttttgaagg 1061821 ctgcaggctg acgagatctg taaaaggatt ctccatgacg tcccactcga tcggttcaat 1061881 gtgatcgttc ttcattttag accatggggg cagacaggct tgtgcaaata aagcatagag 1061941 ccgtgagagc gatccgtcat atgcatgggc ggatgctctg acgccgaaat aacgcgcgag 1062001 ctggaggcag tcccgaaact catcaattcc gttgacatgc atgacatcgg gctgaatgat 1062061 atccaaacag cgctgtgaaa ggagaggcac atattgcgcc gggcctttca tgttttctcc 1062121 gccggcaaca ggaacagaca aacggcttcg aagcatagcg taatcctgcg gctgatcaaa 1062181 gggcaaaggc tcctcaagcc agccaatgtt cgtccattcg gagaaatagc gctcccattt 1062241 aaaagccgca gcggcatcgt agctttggtt tgcgtccaga atcatcgtaa tggagctgcc 1062301 tgctgtatgc tgcagcgcat tgatgtgccg gacatcctcc ttgaatgaag tcccgccaat 1062361 tttgactttg atttgctcaa aacctttttt caactgggct tcaacattgg agactgagcg 1062421 gctgatccat tgcggggagt ctgagtacga ttgaaaagac gcgtacacag gaatctcctc 1062481 tctgtatcgc ccgccccata attcgcaaac cgaacaatcc gcagctttgg ctgcaatctc 1062541 tgtcagcgcc atgcttacag cggaggccgc ccgctggtgc catttttgaa tcgtgcgcac 1062601 taatgacagg cggctgccag cctgttttcc taatagaaat gggatgatcc gcttcgtaaa 1062661 accgacatgg agagcaggga gccaatcaac gcattctccc cagccgtcta tcccgctttc 1062721 ggtgataatc ctgatgagat aacaagtccg atatcgttta aacccattgg catctccgta 1062781 tggcttttct aatcgatgaa atagcggaaa ggtttcaatc cgtacaattt tcacactggg 1062841 tgctaccttt cctcagcggg ctggagccga ttgccagcca ttttagggtc ttctttttct 1062901 tttgtttctt cattgttttg cttcacatgg atgagcatca tcacaagaat cccgacaacg 1062961 agagtcaatc ccgcgatgct taaaaacatg ccgggtctgg accattgcat caggcggccg 1063021 aaaatcggag gaccgatcgc tacccctaag aaacgtacag agccgtacag cgaggtgaca 1063081 aatccccgtc tttctttgcc gacagccccg gtaatgaaac tgttcacaca aggaaggaca 1063141 agacctgagc ctatactgct cagtacaaga acactgataa aaaggacaag attttcaatg 1063201 aatgacagtg ccgcgtagga tacggtcatg aacgccaatc caagtacgat cagctttttc 1063261 attaacgatt gcttttgccc gattttgctt cctgttgtat aggacgtcac acacataacc 1063321 aaaagcggga tcgctaaaat taagcctttt ttcacgccgt cggtgtcgta tgttttttca 1063381 agaacatctg agagataaaa caggatgccg aataaagtaa acaaacaggt cgcaccggct 1063441 aaataagcgg taaacagcca tctgccttca tgtttaaaga cacttaacag cccttttgca 1063501 tattgtccga ttggtggcgg ttctttttcc tttttctttt ctttaataaa aatccaagtc 1063561 agtacgatcg aaatgataca aaacacagga aaggcaaaaa acgcgccata ccagacaagc 1063621 agggcgatca gcgagccaat gatcggcgat agcactttcc ccatgccgtt tgaagcttca 1063681 acaaggccga gcaccttgct ctcctgggcg cctttaaaca gatctcccgt cagtgccatg 1063741 gcaattgggc cggttccggc tgccccgatt ccctgtaacg ctcgtcctgc catgacccaa 1063801 ggataggcat tgtcaaaaaa acctgccgca aacccggcta acaaaccgcc ggcaccatac 1063861 aaaattaagc agggaataat gatgactttc cttgagaatc ggtctgcgag ataaccgaca 1063921 atcggaatcg caaatgctgc aatcaaggaa aatactgtga tcacgagact gacttgaaat 1063981 tgtgataaat gaagttcaga tttcattttt ggcaaaatcg gaataagcat cgagtttcct 1064041 agggttaata ttaaagggat tgaaccgatt gccacaatcg tcattccgtt attttgtttt 1064101 gatgattcca tctcagagca cactcctttt cttctgctta gaatgtccct gatggcttcg 1064161 tttattcagc gatcagacag caaaaaaccg aacagaagat acctgttcgg gaaaaaagag 1064221 ggttaaccga gagcctgtga aatcaaagca tataagtgtc cattttgaat aggcgctttt 1064281 ttctgataga acaaaatcgg aggttcatca tctttatgaa atcccatttc tatcaggctg 1064341 tcatgcagag acgtgtgttc actcggtata tcgattcgca tcggcccttg tttgccggcc 1064401 gccagccttg taattatctg tgctgcaaca tctgatgatg gagcgatgat agggccgaat 1064461 ttcaaattgg ccggtgtctg tacagaaagt ccgtagccaa tgagctgtcc gtcctgattt 1064521 ctggcgatga tacattcgca tgaagcagaa ataagctgct gcaaaaggtt tgatcgatct 1064581 ccgccaaagg cagccagatc cgccgcggtt aagtcgtgaa agtcttgttc tctaaaggat 1064641 gtcagttcag catcaagctt ttttgtataa ggttgaaaac tgtgacagct gtactttcgc 1064701 actgaacctg ccgtatgaaa acctgctttt tcataaagcg gcaaaccttc ttttgtggcg 1064761 caaagcctga tggcggtgtt ttcatccgtt tgggtaatac aggcgtttac catacgccgg 1064821 ccaagaccga gccgttgata ttccttgtca acgataacaa ggccgataga agtaagacgg 1064881 ccaaacaaaa acaagccgat gcaggaaata atatcaccgc tgacattttg ataaccgaaa 1064941 aagcgtccct gctgaacaag cagtttcagc tcttgttcgc cataatccgg ccacccggct 1065001 tgcccgcaaa gccgcaataa gccggaaacg tgttcttcat gaagcttaat cagttcatct 1065061 actacgtcca taagatcacc tgcttgttct aagtgttttg tacatgacaa tatgattgcc 1065121 aatgccggga atgtcaaatg gttcgccaag ttccttccag ccaagcttgg catagtagcc 1065181 cttgacatgg tgtcttgcgt tgcaccatac cgcctgaacg ccgctctccg ccagtttgtg 1065241 ctccgcgtgt ttgatcagcg tgcttccagc tttttgatcg cgatatccct cgagcgttgc 1065301 catgcctctc agccgatacg cagaggcttc cgttaataaa ggctgacttt gcggggaaaa 1065361 agaagcgatg ctgatcagcg ttccatcata aaacacgccg agatgaaagg agccttctgc 1065421 gtgatcctct ttatatttgc attgttcgat ggattgatgg ggacgcagaa tgcgatgccg 1065481 gatttcatat gtatcttcca cggaaatggt tttgacttcg agcataatgt tcctcctcat 1065541 gattgttttt ctatatcgta acacgaatct cgttgaaaaa gactgcccga ttcgatcagg 1065601 cagtcttttg gaaattaatg caaaaagata ttttggcgct gctcatcttt ttgctgaata 1065661 tatgatgtga gctcagcggt taagtcagat ctgaggaaag gcgttatcaa gtagatgccg 1065721 ttaaacagct cgcatgccgt atccagcagg gagcgtgcaa ttgcaaggcc ttccgccttt 1065781 tgcttttctt tatcttcacc ggcatgggcc attttttcgc gaatcgtatc agacagctta 1065841 atgccgggaa tttcattatg gatgaattcg gcattccggc tgcttgtcag cggcatgatg 1065901 ccgatataga tcggcgtctt cagatgtttt gtttcgttat ggatatcgac aagctgctgc 1065961 tcggaataga caggctgaga aacaaaataa tctgcgccgc aatctatttt tttctcaagc 1066021 cgttttaccg ctttatccag atggcggacg ttaggattaa atgcggcggc aactgagaaa 1066081 ttcgttttct tgccgagcgg ttttccagac agagacagac cttcattgaa ttgtttgatc 1066141 agcctgatta aatcaaaaga tgttaaatca tatacagacg tcgccccagg aaaatccccg 1066201 attttagaag ggtcacctgt aatagcaagc acgtcattca gccctaacgt atcaaggccc 1066261 attaaatgtg actgtaagcc gataatgtta cggtcacggc acgtaatatg gacaagggaa 1066321 cgcatatcga gctgctgctt gacaagggcg ccgcaggcaa cattgctgat ccgcggggtc 1066381 gccaaagaat tgtcggcgag tgtcagggca tcgattcccg cttcttttaa ttcagcagca 1066441 gcggacagaa atttgtcaaa gcttagtttt ttcggcgggt ccagctctac gataatagag 1066501 cgttttttcg ctgcgatctc atccaggccg ggctcggttc gctcgtgatg aacagaaatg 1066561 aattctttcg cccgggtttt gacttctttt tccgtaatcg gagccagccc gccaaccgct 1066621 tccgccatcg ccctgatgtg attcggcgtt gtgccgcagc agccgccgat aatccgcgca 1066681 ccttgcttac ggaattctga cgcgctgttt tgaaaatacg tgtcgtctgt ttcatagacg 1066741 agccgtccct cttcaagcga aggaagactg ctgttcggat aaacggataa gaatacgtca 1066801 tcaaaaatcg gcacttcgct tagcgcttca atcatgtgat aagggccgag gcggcagtta 1066861 atgccgacaa tatcagctcc gagatccgca atcgagcgca atgcgtcaga aagcggcgtt 1066921 ccgtcctgca atacgccttg ctcgtgcatg gagacattga gcataatcgg aagatcagtc 1066981 tctttgcgcg cgattttcag cacttcacgg gcttcttcca aatcataata tgtttctaac 1067041 agcaagccat ccggctcttc atgcagcagc agatacagct gctcgcggaa gctgcgctta 1067101 atttcgtcaa gactgtatgc gtttttatta aatgtgcgta tgccgcccat cgttccaagc 1067161 acgtatgcat cgcctgctga agcccgcgcg atctttacgg cctcctgatt catttttttg 1067221 atgtcatcct caagcccgtg tctggataat ttaatatagt tggctccgta cgtattcgtt 1067281 tgaataatgt tggctcccgc ttcaacgtac gctttatgta tgcgctgaat ttcctccggc 1067341 tttgaaatat tgagctcctc aaaacacctg tcaatgccat aggagtagag gagcgtcccc 1067401 atggcgccgt caccgattaa cacctgtctt tgcaaatctt ctaaaagtcc cattgtctgc 1067461 ctcctttatt cacatcagca aggaaaaaag agaaataaaa aaagtcctct taagaagaag 1067521 actttgtcag tgattttgtc tcttcttatc ttccaagctg ttcgagcttg ctggatttag 1067581 caccttggtc atggctgatc gccattacac cggttgctga agcttcgtcg ggccagtccc 1067641 tctgcttctc ttgataagaa cggatatgaa attttcgtgt caggaagtgc caaaagatat 1067701 ctggcgtttt tccctttctc caaatttacc gaaaataaag acaataatca ataggaatca 1067761 gaaaatttat ctgaaattta taaattgaac gtcaattggc agatctgctc cccgtacagc 1067821 tgagataatc tgctgcaggt catctttgtt ttttccggtg acacgcactt gatcatcctg 1067881 cacctgagac tttactttca gtccggagtt tttgatgatc gtattgattt tttttgcgtt 1067941 gtccttgtca atgccttgaa caagctttgc acgctggcgc accgttccgc ctgacgcgtt 1068001 ttcaaccttg ccgtaatcaa tgttttttgt cggtacgttt cgtttaatca atttgctgac 1068061 cagcacatct ttcagctggc ttaatttgaa ttcgtcatcg gaaacgagga ccagctcctc 1068121 tttatctaaa gaaatgtcgc ttttgctgcc tttaaagtca tatcgggtac tgatttcctt 1068181 cagtgcgatt tggattgcgt tttgcacttc aggcaattcc accttggata caatatcaaa 1068241 tgaactttct tttgccatat gaaaacctcc ataacattta acttatgtgt tgattatagt 1068301 agaataaaga gaaacttcca acagaacaaa gaatcaattt gtgatgattg gaaaaaatgt 1068361 taacaaaatc cgcagagaat aagcggaaca ggaaggacga tagcatgaga ccagggcagc 1068421 aattaacctt gagtatagat caccaaaccg acttcggtta ctttttaacc gatggggaag 1068481 atacgattct cttacataac agtgaaatga ctgaggatat cgaggacaga gacgaagtag 1068541 aagtctttat atacgtagac cagcaggaaa ggcttgcggc cacgatgaaa attccgatca 1068601 tcagcgcgga tgaatatggc tgggttgaag tggtggataa agtggaagat atgggcgttt 1068661 tcgttgatgt cggtttatcg aaggacgcac tagtcgcaac tgagcatttg ccgccgtacg 1068721 aagatgtctg gccgcaaaaa ggggacaaac tttactgtat gctgaaggtg acgaaccggg 1068781 ggcgcatgtt tgcgaaacca gcgccggaag atatcatcag cgaactgttt accgacgctt 1068841 cagaagatct gatgaataaa gagctgacag gtacggtgta caggctgatc gcatcgggtt 1068901 cattcgtgat cacggatgac ggtatccgct gttttattca cccgtcagaa agaaaagagg 1068961 agccaagact gggttcaaga gtcacaggcc gggtgattca agtgaaagaa gacggttcag 1069021 tcaacttgtc gctgcttccg agaaaacagg atgcaatgtc agttgatgct gagtgcattc 1069081 taacgtatat gagaatgaga aacggtgcca tgccgtacag tgacaaaagc cagcctgacg 1069141 atatcagaga acgttttaat atgagcaaag ccgcctttaa acgcgcgctg ggccatttga 1069201 tgaaaaacgg aaaagtgtat caggaaaatg gatggacata cgagaaaaaa tagcatgaaa 1069261 acggctcgcc tgcagcagac tgcggagcga gccgtttttt tatgtctagt ttaattcatc 1069321 aaccagcggc caactatatc atattaattt gccaaaatcg tgttcaaata tttgttttaa 1069381 gggaaaacat aataaagaag aaagagcgga ggaacatgcc atggtactag atcaaacaaa 1069441 aaaattactc atcgtcatca tcggcgcttt actcaatgct gccgggctga acttattttt 1069501 gatacctgca gatgtatatg ccagcggatt tacaggtgtt gcccagcttt tatcaagcgt 1069561 cgttgatcaa tatgccccct tttacatatc gacgggaacg ctcttgttcc tcttaaacat 1069621 tccggtcggt attttaggat ggctgaaggt cggcaaatcg tttacagtgt acagcatttt 1069681 aagtgtcgca ctcactactc tgtttatggg gatcctgccg gaaacaagcc tgtcacatga 1069741 cattttgctg aacgcggtgt tcggcggcgt catttccgca gtcggtatcg gcttaacatt 1069801 aaaatacgga gcttcgacag gcgggcttga tatcgtcgcc atggtacttg caaagtggaa 1069861 ggataaaccc gtcggcacgt atttcttcat tctgaacggg attatcatct tgacggcagg 1069921 attattgcaa ggttgggaga aagcattata taccctggtt acactatatg tgacaacgag 1069981 ggtgatcgac gccattcaca ctcgccacat gaagcttacg gcaatgattg tgacgaaaaa 1070041 agcggacgaa atcaaggaag ccatttacgg aaaaatggtg cgcggcatca caactgttcc 1070101 ggcaaaagga gcatttacga acgaacagaa agaaatgatg attatcgtca tcacgaggta 1070161 tgaactgtac gatttagaaa agatcgtcaa agaagttgat ccaaaagcat ttacgaacat 1070221 cgttcaaacg acagggattt ttggtttctt tagaaaagac tgacgaaagc aggtggaagt 1070281 cgtgaaacgg ctgcttgtga tgctcctccc cgtgctgctt ttgataggct gcgggaaaga 1070341 tgagcagaca gaacccgata aggaggtatc aggcggaatg gagaatcaag aggttgtttt 1070401 atctattgac gcaattcagg agcctgaaca aatcaagttt aacatgtcgc tgaagaacca 1070461 aagcgaacgt gctattgagt ttcaattcag cacagggcaa aaatttgaac ttgtcgtgta 1070521 tgattctgag cacaaagaaa gataccgtta ttcgaaagaa aaaatgttta cgcaggcttt 1070581 tcaaaacctg acgcttgaat ctggagaaac atatgatttc tctgatgtgt ggaaggaagt 1070641 ccctgagccc ggaacctatg aggtaaaggt gacatttaag ggcagggcgg aaaatctcaa 1070701 gcaggttcag gctgttcagc agtttgaagt caaataagag gctatggcga gtcgccatag 1070761 ccttttttta ttgcagtttg tccagctgat tttgaaattg atgcaactgt tgacgttccg 1070821 catctgtcga attggcatac gcagaagata cagcattttt ggctctcaga atcgcttgct 1070881 cctgatcgcc ttcctcaaag ccgtttgtca ccatgaccgc ctgttgaaca aatgattttg 1070941 cctgctgaaa cagttcattt ctcatttaat attcatactg cctttcagcc gagtctcgtg 1071001 ccgcggcatg ctggtgagct tcttctaaag tagaccgata tggaaatctt gcggcgtgta 1071061 gcccgatgga gtctttaccc tgctgaataa accttctgga tttgcttcgt ttacccattt 1071121 tgagactgcc cccttccata ctttgacgag atgagtcgtc ttcaatagta tggtggggta 1071181 aagtaaggtt tatgagtggg aaaaattaat acggaccttc tttaaagtga gaaatattct 1071241 ttcaaaaacc ttgccacgcc gtcctcttca tttgtggccg tagttcggtt ggcaatctgc 1071301 ttgaccgcgt caattccatt tcccattgca acgccgcagc ctgcaaattc aagcatttcc 1071361 aaatcgttat cctcatctcc aaaagcaatg atccgctccc tcggcacgcc gtaataatcg 1071421 ctgattttct gcaggccgac cgctttattc atgccgcttt tgataatttc aatgacatgc 1071481 caaggagcgg cccatcttct atggtcgatc acctcggcat gcacatccga taaatatgag 1071541 cgtattgccg gcacatcctc ttcctttgca tgtatgagta cggacgtcac atcttcaccg 1071601 agattttccc gcaagtctcc gaccgttaca tttgttgtgt tcatgttaaa ggcatctatc 1071661 aggtgctcat catggtaatg aaagtatacg tcgtcaatca cttcagcaag cacgttatgt 1071721 acgttgtagc tctcgctgat atccacgagc tgtttgacaa catcaagcgg cagtgacgta 1071781 tgataccgtc cccagctgtc gtcttgcgga tgatggacaa atgctccgtt aaaattgaca 1071841 attggcgttg tcagctccat ctgctggtag tacatggaac ttgaacgata cggacggcct 1071901 gttgagatgc agacataatg cccgtcatct tttaggcgct gtatcgtatg aagggtgttt 1071961 tcagatatgg ttttatcatc ctttaataat gttccatcta aatctaatgc gattaaatag 1072021 ggttttgtct ccatgaaaag ctcctttaac cttagatttt gcttgttttg ccttacttac 1072081 agtgtagctt tttaccatct ttattgtcta catgttacac ttatgattat ggttatccta 1072141 aggaggggca cattgtgata caaattgaga atcaaaccgt ttccggtatt ccgtttttac 1072201 atattgtaaa ggaagagaac aggcaccgcg ctgttcctct cgtgatcttt atacatggtt 1072261 ttacaagcgc gaaggaacac aaccttcata ttgcttatct gcttgcggag aagggtttta 1072321 gagccgttct gccggaggct ttgcaccatg gggaacgggg agaagaaatg gctgttgaag 1072381 agctggcggg gcatttttgg gatatcgtcc tcaacgagat tgaagagatc ggcgtactta 1072441 aaaaccattt tgaaaaagag ggcctgatag acggcggccg catcggtctc gcaggcacgt 1072501 caatgggcgg catcacaacg cttggcgctt tgactgcata tgattggata aaagccggcg 1072561 tcagcctgat gggaagcccg aattacgtgg agctgtttca gcagcagatt gaccatattc 1072621 aatctcaggg cattgaaatc gatgtgccgg aagagaaggt acagcagctg atgaaacgtc 1072681 tcgagttgcg ggatctcagc cttcagccgg agaaactgca acagcgcccg cttttatttt 1072741 ggcacggcgc aaaagataaa gttgtgcctt acgcgccgac ccggaaattt tatgacacga 1072801 ttaaatccca ttacagcgag cagccggaac gcctgcaatt tatcggagat gaaaacgctg 1072861 accataaagt cccgcgggca gctgtgttaa aaacgattga atggtttgaa acgtacttat 1072921 aaagcactaa gttattaaca agagctgaat ttacgttata ctgtagaaaa aaggagtgag 1072981 ggaacgtgga agaagcatta aaagaaaaca tcatgggcgc cctggaacag gttgtcgatc 1073041 ctgagcttgg cgttgatatc gtgaacctcg gcttggtata tgacgttgat atggatgaag 1073101 atggcttgac gcacatcacc atgacgctaa catcaatggg atgcccttta gcgccgatta 1073161 tcgtggatga ggtgaaaaaa gcattagcgg accttcctga agtgaaagac acagaggttc 1073221 acattgtatg gaatccgcct tggactaggg ataaaatgtc cagatacgca aaaattgcgc 1073281 ttggcattca ataaaacaaa aaaggacagc ctgacatgtg aggctgtcct tttttacagc 1073341 tgaaaggagt gaaaggaaat gatgtacctg ctggcagttt tatgcccgcc gcttgctgtt 1073401 ttgttttcgg gaaaaccgtt tcaggccttg ctgaatctca tattgacctg tatcttttgg 1073461 ctgccgggcg cgattcacgc ctgctttatc gtcgccgacc gccgtgccga aaaacgggca 1073521 agaagataat ttggaaaaat gaggacgcag tcatggtata atggtcataa aaacagcagg 1073581 gagagcacta tgaaaaagaa attgcttgca ttcgcgcttt gtactggcgc gtatgcggcc 1073641 ctgtttgcgt actctgtgaa ctcagagcaa aaaacagcca caagcgagat gacggatgtc 1073701 agccgcctga tgcctgtaaa aataaagcag acagtgaaag ggcaggaaga ggaaatgctc 1073761 attgacacag tcaaagaggc aaatcgaaaa aacataaaaa tttcaatcgc cggggcccag 1073821 cactccatgg gcggccatac atattatgag gacggcatcg ttctcgacat gacgggctac 1073881 aacaaaatcc tgtcactcga tcaagagaag aaaaccatca gggtgcaaag cggtgcaacg 1073941 tggaatgata tccagaaata cgtgaatcca tacggactcg cggtaaaagt catgcagtca 1074001 caaaacattt ttacaatcgg cggatctctc agcgcaaatg cacacggacg tgatattcgc 1074061 tacggctcgc taattgatac agtcaaatca ttccggcttt taaaagctga cgggatgatt 1074121 atcactgtca ctccaaaaga tgatttgttt acggcggtca tcggagggta cggccttttt 1074181 ggcgtgattc ttgatgtaac gcttgagctg acagatgatg agctgtatgt catgaagaca 1074241 gaaaaaatga attacagcac atactcagac tatttttcaa agcatgtaaa aggaaatcca 1074301 gatgtccgaa tgcatctggc gcgaatttca acagcgaaaa aaggatttct gaaagacatg 1074361 tatgtcacga attacgtatt ggctaatcat caggatcagc tgtcctcata cagcgaactt 1074421 aaagaagacg agtatacggg agccacaaag tttgcactcg gcttgtcaag acggtatgaa 1074481 tgggggagga attggctgtg ggacacacag caatcctatt tcctgagcca gaacggcaca 1074541 gagatttcac gcaataacgt catgcggtcc gaatcaaagt ttcttgagta tgaaaacaat 1074601 gacaacacag atgttttgca agaatacttt gtgcccgtga aggagtatgg gtcctatatt 1074661 gatgacctga gacaaacgct gtcggacgaa gatctgaacc tgctgaacat tacgatccgc 1074721 tacgtgcaga aaaatgaaaa ggccgacctt tcctatgcga aggacgatat gttttcgctc 1074781 gtactattaa taaacgaggg cttttcaaaa gaagaccagg cagataccgc ccgaatcatc 1074841 aggcgcatga cagacgttgc catcaagcac ggcggcagct attatctgcc ttatatgacc 1074901 taccagacaa aagcgcaaat gagacaggca tatccgaaaa gtgaagcgtt ttttcagaaa 1074961 aaacgaacct atgacccgga tgagcgcttt atgaattact tttatcagag gtataaataa 1075021 tggggaaaaa caaattaaaa tggctgacat tatcacaaag cagcgtgttt ttcgcaagca 1075081 gcttaatctt tccgttttat attctgtttg tgaaaaatat cggctcaagc tacacacagt 1075141 tcggtttttc ctacggattg ttcgggttga gcggagcgct tatttacccg ctcctcggac 1075201 ggctgtctga aaggtttgac agccgttatt ttctgcttct gaactcgtgg gggatggctg 1075261 ttctgctttt atatgtcccg catatcggaa gcgtcgttca agtgtatatc gtccaagtgc 1075321 tgttagggct ctttggagcg atgcaaaagc atggagaaaa agtgctgatc gctaatttta 1075381 cagacagtgg agagcgtgga aagaagatcg ggaattacca tttttggaca gctgtctttt 1075441 cagcagcagc cattatgctc gggggctttc tcgctgactt tttcacagtg caaatgattt 1075501 tttatgcaag ctctattcta tattttttga gtggattgat gatgatgaaa acaggctgac 1075561 gcggtcagcc tgttttttta tgcggctgaa atgcggcacc gcatcaacgt ttttgtgctg 1075621 gagtcgtgct gatttttttt gagcggaatt cccattgaac agaaaattta taaatgaata 1075681 aaaatattaa atatacgatt gaattaattt ttattcatgt tataatgtta aataatttca 1075741 caaagaccaa gagggtgaac ttgttttgaa aataggaatt gtaggtgcta caggatatgg 1075801 aggcaccgaa cttgtcagga ttctttcgca tcatcctcat gcagaggaat gcatacttta 1075861 ttcatccagc ggagaaggga atgtctatag cgagggttat cctcatctta ccggcttagc 1075921 ggatcagcag ctgaagccga ttgatatgaa tacgatcaaa cacgaaatag atatcatgtt 1075981 tctcgctgcg ccgcccggag tatcaagtga attgactcca aagctggcag acgcgggaat 1076041 tacggttatt gatctgtcag gtgatctgag gataaaagaa ccggctgaat atgaaaaatg 1076101 gtataaacgg acagcggcac cgaaggcggt gattcaagag gcggtatacg gtctggcaga 1076161 actgaatcaa ctgcaaattc aacaggcgaa actcattgcc aatccaggct gttttccaac 1076221 agctgttttg cttggcctcg cgccattggc tcaaaagaaa ctgctcgatg aatctttcgt 1076281 tatcgttgac gcgaagaccg gtgtttccgg agcgggaaga aaagcatcca tgggaactca 1076341 tttttctgag ctgaacgaca attttaaaat ttataaagtc aatgaacatc agcacacgcc 1076401 ggaaattgag caggcgctga atgaatggca gccaggtctc gggcccatta cattttcggc 1076461 tcacttggtt ccgatgacaa ggggcatcat ggcgacgatg tataccagat taacctgtga 1076521 cctaaccgca gatgacctgc atgatttata ttcggaattt taccaagatt catattttgt 1076581 gagagtgagg ccaaaaggtc agtacccgca aacgaaagaa gtgtacggca gcaatttctg 1076641 tgatatcgcc gtgaccctcg atgagagaac gaacagagtc acgatcgtct cggtaatcga 1076701 taatttaatg aagggtgccg ccggtcaggc agtgcaaaac tttaatttga tgaatggctg 1076761 gaatgaagaa actggactca ccatcacgcc aatttatcca tagaacggga gagaatcgaa 1076821 ccatgattca gttaagtgaa gatcaaattg taaaagtaac aggtgatgta tcctcgccaa 1076881 aagggtttca ggcaaagggt gtgcattgcg gactgcgcta ctcgaaaaaa gacctcggcg 1076941 tcattatcag cgagacaccg gccgtgagtg cagcagttta tacccaaagc cactttcagg 1077001 ctgctccgat caaagtgaca caagacagct taaagcacgg accgacactg aaagccgtca 1077061 tcgtcaacag cgccattgcc aacgcctgca cgggagaaca gggcttaaag gacgcataca 1077121 caatgcggga gagctttgct tcacagcttg gcattgagcc ggagcttgtc gctgtttcat 1077181 caacgggtgt catcggcgag catttagaca tggaaaaaat ccacgcgggg atcgaactgc 1077241 tgaaagaaac acctgcggga tcaggcgatt ttgaggaagc gattttaaca actgatacgg 1077301 tgatcaagca gacgtgctat gaactggcaa tcggcggcaa aacagtcacg atcggcggag 1077361 cggccaaagg ctctgggatg atacacccga acatggccac gatgctggga tttgtgacaa 1077421 ctgacgcggc aatcgaagaa aaagcgctgc aaaaggcgct tcgggaaatc actgacgttt 1077481 catttaacca aatcacagtt gacggagaaa catccacgaa cgacatggta ttagttatgg 1077541 cgaatggctg cgccgaaaac gagtgcctga cagaagacca tccagactgg ccggtcttta 1077601 aaaaagcgct cttgctcact tgtgaggatc tagctaaaga gattgccaga gacggagaag 1077661 gcgcgacaaa actaattgaa gcccaagtac agggagcgaa aaacaatctt gatgcaaacg 1077721 tcattgccaa aaagattgtc ggctcaaatc ttgtaaaaac ggcagtatac ggaacagatg 1077781 ccaactgggg gcggatcatc ggagccatcg gacactccgc agcacaggtg acggcagaag 1077841 aagtagaggt ttatcttggc ggccaatgcc tgtttaagaa taacgaacct cagccattct 1077901 ctgaatctat cgccaaggaa taccttgaag gagatgaaat caccattgtc atcaagatgg 1077961 ctgaagggga cggaaacggg agagcgtggg gctgtgacct gacctatgac tatatcaaaa 1078021 ttaacgcgag ctatcgcacg taataaaggg gagcgaaatg aagaaaacaa tcgtttttaa 1078081 atgcggggga agcgtcatcc gtgagctgtc ggaggaattt tatcaaaatc tgaaagagct 1078141 gagggcgtca ggctggaagc tggcaatcgt acatggcggg ggaccggaaa tcacaaatat 1078201 gctgaaacgg ttaaatatca agacagagtt ttcgggcgga cagaggaaaa caacgaagcc 1078261 ggtgctggaa gtggcggaaa tggttttatc cggttctgtc aataaatttt tcgttgctga 1078321 gcttgccaaa cacggactgc gagccgcggg catttctggt aaggatggcg gtcttttgga 1078381 ggctgattat ctagatccgg aaacatacgg agaagtggga gaaatcaaaa aagtcgatgc 1078441 gtccatggtg aacgcgctga tggaaaatgg catcatcccc gttattgcgc cgctgtctat 1078501 gacaagcgac tgcaaaacgc tgaatgtaaa tgctgatctg gctgcttcag cagtcgccgg 1078561 agcgcttgaa gccgataagc tgatgttcgt cacggatgtc gatggaatca tgaaggaaaa 1078621 gcagcgtctg gacgtcctga cccctaagga gattcagatg ctgatcaagc aggaagtgat 1078681 cacaggaggg atgatcccga aggtcaattc agccttgtca gctttatcag atcaggtgtc 1078741 tgaagtcatg atcgtaaacg gtaaaggatc attcttcgca gaacaaacct ttcaagggac 1078801 aaaaattgtc aaagcaaagg aggctgtttc atgagcagct tgtttcaaac ctacggccgt 1078861 tgggatattg acatcaaaaa agcaaaggga acgtacgttg aggatcaaaa cggcaaaacg 1078921 taccttgatt tcattcaggg gattgcggta tcaaatctag gacactgcca tgaagcggtg 1078981 acagaggcag tcaaaaaaca gcttgacagc gtatggcacg tatccaacct gtttcaaaac 1079041 agtctccaag agcaagcggc gcagaagctg gcagcgcata gtgcgggaga tcttgtcttt 1079101 ttctgcaaca gcggcgcgga ggcgaatgaa ggtgcgataa agcttgccag aaaagcaact 1079161 ggaaaaacaa aaatcatcac ttttcttcag tcgttccatg gccgcacgta tgcagggatg 1079221 gctgcgaccg gacaggataa aatcaaaaca ggcttcggcc cgatgcttgg aggctttcac 1079281 tacctgccat acaatgatcc ttctgctttt aaagctcttg gggaggaagg cgatattgcc 1079341 gcggtgatgc ttgaaacagt gcagggagaa ggaggagtca atccggcgag tgctgaattt 1079401 ttatcagccg tacagtcgtt ttgcaaggaa aagcaagccc ttctcattat tgatgaaatc 1079461 cagaccggca tcggacggac gggaaaaggc ttcgcatatg agcacttcgg actctcaccg 1079521 gatatcatca cagtcgccaa aggattggga aacggctttc cggtcggcgc tgtcatcgga 1079581 aagaaacagc ttggagaagc gtttacccct ggttctcacg gaacgacttt cggaggaaac 1079641 atgctggcga tggctgctgt gaatgccaca ttgcaaattg tattccagcc tgactttttg 1079701 caagaggctg ctgacaaagg ggcgttttta aaagaacagc ttgaggcaga gctaaagagc 1079761 ccttttgtta aacaaatccg aggtaaagga ttaatgcttg gaattgagtg tgatggcccg 1079821 gttgctgaca ttattgctga attgcagaca ttaggcttgc ttgtattgcc ggccggcccg 1079881 aacgtgattc ggctgctgcc gccgctcacc gtgactaagg atgaaatagc agaagccgtc 1079941 agcaagctga aacaggcaat cgctcatcat tccgctgtaa accagtgatt ttttttcgat 1080001 ataaaggcat aaaaattcat ttttataatt aattattcat caagaggtgg gctgttagat 1080061 ggaaggttat ttagtgttag aagatgggac atcgttcagc ggcgagctgg acggtcatga 1080121 aaactgcacg ggagaagctg tttttttcac aggaatgaca ggctaccagg aagtgctgac 1080181 agatccatca tataagggac agattattgt atttacctac ccgctgattg gcaactacgg 1080241 cataaatgaa aaggattttg aaagcaagaa accgcaagta aaagccgcgg ttgtctatga 1080301 ggcgtgtgat cacttttctc attatgaagc ggtatacagc ctcaaggagt atctacagaa 1080361 atggaatatt ccgctgttaa cccatgttga tacgagggct gtcgtgaaga aaatccgggc 1080421 aaacgggacg atgggtgcga cagtcacagc ctctaaagaa ggagctgaga ttgcccttca 1080481 accagagaat gtggcagagc aggcttccgc ccaggaaatc agcacattcg gcgacgggaa 1080541 taaacatatc gctctcattg attttggcta taaaaagtca atcgcatcat cacttgtcaa 1080601 acgaggctgc aaggttaccg tggtgccata ccagcaaatg gaggccgtat acaacatcaa 1080661 acccgatggg ctatcgaacg gacctggaga tccgaaagcc attcagccat atttaggaaa 1080721 gatcaaaagc atcatcagcc gctttccgac tctaggcatt tgtctcggac atcagctgat 1080781 cgcgctcgcg tttggaggga atacttttaa gctgccattc gggcacaggg gagctaatca 1080841 tccggtcatc gaccgtaaga cgaaacgggt ctttatgaca agccaaaacc acagctatgt 1080901 ggttgatgaa cagtcgatta atgaagaaga gctcaccatc aggtttcatc atgtcaatga 1080961 tacgtcagtt gaagggcttg cccataaaaa actgcctgtc atgagtgttc aattccaccc 1081021 ggaagcccat cccggacctg cggaaagcga atggattttt gatgattatc taaagaatgt 1081081 gataccagca aggagagaaa tcgcgcatgc ctaaagacac cagtatttca agcatattag 1081141 taattggctc aggcccgatc atcatcgggc aggcggcaga atttgattat tcaggcactc 1081201 aagggtgcat cgcgctgaag gaggagggct accgggtaat tctcgtcaac agcaatccgg 1081261 cgacaattat gactgatgaa gccttcgctg atgaaattta ttttgagcct ctgacagcag 1081321 aaagcctgac agccatcatt aagaaagaac ggcctgatgg gcttcttgcc aatttaggcg 1081381 gtcagaccgc gttgaattta gcggtggagc ttgaagaaac gggtgtttta aaagagcacg 1081441 gcgtcaaact cctcggcaca tccgttgaaa cgatacaaaa aggagaggac cgggaaaaat 1081501 tccgttcgtt aatgaatgaa ttaaaacagc ctgtgccgga gagtgaaatt gttgataacg 1081561 aggccgatgc cctccatttt gcggaatcca tcggttttcc tgttattatc agaccagctt 1081621 acacattagg cggaaagggc ggaggaatcg cccctgataa agaagccttt acagctatga 1081681 ttaagcaggc gctattagca agcccgatca atcaatgcct tgtcgaaaaa agcattgccg 1081741 gctttaaaga aattgaatat gaagtcatgc gtgacagcaa taacacatgc attaccgtct 1081801 gcaatatgga aaatatcgat ccggtcggcg tgcatacagg tgactctatc gttgtggcgc 1081861 cgtcacaaac attgacagac gaagactatc aaatgctgcg gacagcaagt ctgacgatca 1081921 tctcagcact tgatgttgta ggcggctgca acattcaatt cgcgcttgat ccattcagca 1081981 agcaatatta cgtcattgaa gtgaatccgc gtgtaagccg gtcatcggct ctcgcatcta 1082041 aagcgaccgg ttatccgatt gcgaagatgg ccgcgaaact ggcagtcgga tacactcttg 1082101 acgagctgaa aaatccgctc acaggctcga cttacgcaag ctttgaaccg gcactggatt 1082161 atgtgatcgt caaatttccg cgctggccgt ttgataaatt caaaaacgca gaccgcaagc 1082221 ttggcacaaa aatgaaagcc accggtgaag tgatggcgat tgaacggaat ttagaagcgg 1082281 cgatacaaaa ggcagccgcg tcgcttgaat taaaaaatat cgggacacac cttccagagc 1082341 tcagcgggtt gtcaattgat acgctatggg atttggcaat cactccggat gaccgcagat 1082401 ttttcgttgt catggagctg ttgagccgca gcgtctcgat tgatgacatc catgaaaaaa 1082461 caaaaattga tccgtttttc cttcatacct ttgacaacat catcaaattg gaaaaccgcc 1082521 tgatggaagc agggagcgat ctctcttttg aattattgaa gaaagcaaag gaaaagggat 1082581 tctcagacgc aacgattgcc tcgctgatca gcaaaacaga agaagaggtg cgcgcgcttc 1082641 gcaaggagat gggcattacg ccttccttta aaatcgtaga tacatgcgcg gcagagtttg 1082701 atgcgaaaac aaactatttt tactccacat atttcggaga gaccgatgga gacatcagcc 1082761 gcaaagagaa aaaacgcgcg ctcattatcg gatcaggccc gattcggatc ggccaaggcg 1082821 ttgaatttga ttacagtgct gttcacggtg tgctgacact gcaagagctt gggttcgaaa 1082881 ccatcatgat taacaataac ccggaaactg tcagcaccga ttatgaaatt gcggaccgcc 1082941 tgtattttga accgatgaca acggagcata ttgtaaacgt ggcggagcag gaaaatattg 1083001 attttgcaat tgtgcaattt ggcggtcaaa ctgcaatcaa tgctgctgaa gcgctcgaaa 1083061 aagccggcat tactcttctt ggcacatcat ttcaaacgct cgacgtgtta gaggatcggg 1083121 atcaatttta tcagcttctt gacgagctgg gattgaagca cgcaaaagga gaaattgctt 1083181 atacaaaaga agaagccgct tcaaaagcga gtgagatcgg ctatccggtg ttaatccgcc 1083241 catcttacgt tatcggcgga atgggcatga tcattgttga ctcgcaagcc cagctttctc 1083301 agctgctgaa tgatgaggac agcatgccat acccgatttt aattgatcag tatgtgtctg 1083361 gaaaggaagt cgaaattgat ttgatttccg acggcgagga agtctttatc ccgacatata 1083421 ccgagcatat tgaacgggca ggtgtccatt caggggacag ttttgccatt cttcccggac 1083481 cgtccatcac gagcgggctg cagcagggca tgaaagatgc ggcacaaaaa attgcccgaa 1083541 aactttcatt taaaggcatc atgaacattc aatttgtgat cgacaatgga aacatactcg 1083601 ttcttgaagt gaatccgaga gcgagccgca cggttcctgt cgtcagcaaa gtaatgggcg 1083661 ttccgatgat tccgctcgcc acacgtctgc tggcgggagc gtccttaaaa gatctaaatc 1083721 cggcagttca aaatcatcat ggagttgccg tgaagttccc tgttttttct tctcatgcga 1083781 tccaggatgt ggatgtcaag cttggaccgg aaatgaaatc aacgggagaa ggcatgtgtg 1083841 tcgcatatga ttctaacagc gccttgaaaa aaatctatac aagagtctgg agtcaaaaag 1083901 gaagcattta tttgcaaaac gttccggaag atgtgaagga gttagcagaa aacgcaggtt 1083961 ttacaataca tgaaggaaca tttgcctcat ggatggaaca ggaaggaaac tcgctccaca 1084021 ttaatctgag cggttctgaa gaagcacgca aagaacgttt ggaagccatg acgcacggca 1084081 tccccgtctt tacagaagaa gaaactgtgc gggcgttttt acaaagcggt tcaggccatc 1084141 cgcagcctgt atctctcaaa gacctctata aaaaggaagt ggcatcatgc acacagtgac 1084201 gcaaaccagt ttatacggaa aagatttatt aacgttaaag gaccttagtg aagaagatat 1084261 aaacgccttg ctcgcagaag ccggtgagct gaaacaaaac aaaattcagc ctatattcca 1084321 tggcaaaacc ttggcgatga tttttgaaaa atcatcaacg cggacccgtg tttcatttga 1084381 agcgggcatg gcgcagctgg gcgggagcgc cctctttcta agccagaaag atctgcagct 1084441 ggggcgcggt gagactgtcg ctgatacggc aaaagtgctg tcaggctatg tggatgccat 1084501 catgatccgg acctttgaac atgaaaaggt ggaggaactt gccaaagaag ctgacattcc 1084561 ggtgatcaat ggacttaccg ataaatacca cccatgccag gcgctggcgg atctcttgac 1084621 gattaaggag ataaaaggga agcttaaagg cgtaaaagtc gcgtacatcg gtgacggaaa 1084681 taacgtggcg cactccttga tgatcggctg cgcgaaaatg ggctgtgata tctcgatcgc 1084741 ttcaccaaag ggatatgaag tgttagatga agcagctgaa gcggcaaaga catatgcact 1084801 tcaatccggc tcttctgtca cgctgacaga tgatccgatt gaagctgtaa aagacgcgga 1084861 cgtgatttat tctgatgtgt ttacaagcat ggggcaggaa gcggaagagc aagaacgtct 1084921 tgctgtcttt gcgccttatc aggtgaatgc ggcgctggtc agccatgcca agcctgacta 1084981 tacattttta cattgtctcc ctgcgcatcg cgaggaagaa gtgactgcgg agattattga 1085041 cgggccgaac tctgcagtgt tccagcaggc ggaaaaccgt cttcatgtgc aaaaagcact 1085101 gctgaaggcc attttatata aaggggaatc atcaaaaaac tgctgagcca aactcagcag 1085161 tttttttgat ggcaacatat tcacagccgc ttaggcgcat actacagcaa aaaggaaaag 1085221 gaggaaaaac agtgggacag cagcaccaat tccggcccgg acagaaagcg cctaataacg 1085281 gtgtctacgt agaaatcggc gagacaggga gcatggttaa aaaccctcaa aaggtccatc 1085341 tgtcagcagg ggaaatgttc cccgaaacat caaaccacaa ccggctgtgg acctacaaaa 1085401 gaaagccgtg accactaaaa aacccaaaac aataaatgtt ttgggttttt ggctttttaa 1085461 tgctggcttg catttttgtt cataggcatg atttctgcta aaaccatgat taagacatac 1085521 agtacaacag caatgacaga tgatgttttg aaattatacg taacgctgtt catgcttgca 1085581 accaagtagc atgccatatg tgataaaagg aacgtccaaa taaaggcaat aatatatcgc 1085641 acgtttccac ctcgtccttc tcattctatt ctaaaagtta tcataccata caaaaagcga 1085701 agggggaatc caattttagc agaaagtgag gtgacaaaag agtctgattc gtcacacttt 1085761 aatggtaaaa tataaaacgt caatcagtat aatagccaaa aatgtaaaag gctaggactt 1085821 taccttattc gtttcttttc tatttacata agatagcgtg agatgaagtg tgaaaggagg 1085881 cgggcaagcg atgggaataa cggaaagata ctttcaactg ggaacggagc ataatgtcat 1085941 tcatctgccc tatcgcccga acggcttcgg catctttatc ttgggggaca gaacccactt 1086001 tgtcggacat gattcaagct tttggcagca gcattatggc agaaatcagc ttctgagcat 1086061 gttgatgaat gaaggataca ctctttttaa cagcaatctg ttcggaaggc attggggggc 1086121 ggaaaaagca gtcacctatg ccaaacagct gatacattct gtgctgaagc aggaaatcct 1086181 caatccgaag attcatattt tagcagaagg catgggtgct ctcgtggccg atgaactgct 1086241 tcgtttttcc ccggatcata tccgctcagc cgcaatgttg aatccttgtc tcgatcttca 1086301 ggcacattat gaatcggaaa aagaaaataa atttttctat aagcaatttt tgaaagaagt 1086361 atcgaaaagc tacggaattt ctgaaaaaga agcggaagcg attcgttata aaacaattca 1086421 aagctacccg agcggcgtac cggttcatat atggcagcgt atgaccggag ctccatatcc 1086481 ctacagcgta catgcggaag ttttcaagga aaaacagcaa aagcaaggct caccggtcga 1086541 catgacattt catttatttg agcatccaag cagaatttat gcatcaattt gcaaattctt 1086601 tcatagtcat gaaaaagaat tatagagaat ataatgacaa cagccttctc ttttgcggag 1086661 gctgttttgt tttgggaaat gaaaaaccgg aagggcggca gatgcaatgg aatcaacgct 1086721 gattgtaggt gcggacgaat ttttcggcct ttcattatgt gagcgaatga tggatgaagg 1086781 catacatgtt gacgttgttc tggcggaaac agaagataaa atgagacaaa tgtacttaga 1086841 agaaagactc atgtggcttg ggagaaatga actctttcgc cagcttgaac acattggaga 1086901 ccaaaattat gatacaattt gtatccagtt cggaagtttt ttgcctttag accaatatga 1086961 ttctccttat attttagtat atgaagaaga ccgaaaagaa tgggataaac gtgaaaaaac 1087021 aggctcggaa aaaaccgtga tcctgccgaa aatgtacggg ccatggaaag aagaaacaga 1087081 ggaagacggc tattacacaa acgacgtggc tgacgagttg ctgagattcc tgttagaacc 1087141 aagccgtcat agcaaagatc agctttttga attgcaagtc acagagaaaa cctcaaaaga 1087201 agaagcaaaa acaaaaatta tcgagtggaa aagacaattt tcatcaattt tcgacaaata 1087261 ttaagaaaaa ccttccatgt ttcgagtttt ctagatacaa taaacgtata aaaataatac 1087321 atgttatagc ttgtcaaaag gagttgaaca tgacttgatc acaaggcttg tcatgatctt 1087381 ttctgtcctc cttttattga gtggatgtgg acaaactccg ttcaaaggaa aaattgagaa 1087441 ggtcggcatg ctctttcctg atacgattaa tgacctcgta tggggcacaa aagggtataa 1087501 aggattactg aatatacaat ccaaatacaa tgtggacgtc tattataaag aaggcgttaa 1087561 aacagaagaa gatatcataa atgcgattga ggattttcat aagaggggcg tcaatctgct 1087621 ctacggccat gggagtgaat atgctgaggt gtttaacttg gtcggcgaag attatccaga 1087681 tatggaattc gtcatttcca atgcgaaagc gaaagctgat aatgtaacaa gtgtccattt 1087741 tagcggggaa gcaatgggct tttttggagg aatgactgct gcccatatgt cgaaaacgaa 1087801 tcaggtcggt gtaattgctt cctttacgtg gcagcctgag gttgacggtt ttatcaaagg 1087861 ggccaagtat gaaaatccgg atatagaggt aaatacgaaa tatacggatc attgggatga 1087921 tgatacaaca gcagtaaagc tttatcagaa aatgaagaac gaaggcgcgg atgttgtgta 1087981 tcccgccgga gacgggtata atgttcctgt tattcagcaa atcaaaaaag acggtcttta 1088041 tgccataggc tacgtcacag atcaatcgga tctgggcgag aataccgtat taaccagcac 1088101 ggtgcaaaat gtggacaagg cctatgaaat cattgctgaa caatttaata aaggcaccct 1088161 tgagggcggc gatcattact acgacctgaa cacgggagtc gttgagatgg gaacattcag 1088221 cccgctcgtc gatcaagact ttcagcaaag aatcgccaag ctgatcaaaa catacaacaa 1088281 aacaggcgag ctgccaaaaa acgagtaatg gagtgacgtc acatgcagca cgaaaaatca 1088341 cttgaattct tgcaaattgc catgaaatat ctccctgaag cgaaagaaca gcttgagaaa 1088401 tcaggcattg agctctcaat ggaggccatc cagccgttta tgaatctatt tacaacggta 1088461 atggcggaag cttatgagct tggcaagtct gacgctaaat ctgaaacaga ataagaagaa 1088521 gccacttttt tgaaagtggc ttttcacatg attttctttt taatagcgga gagcatgggc 1088581 gcaagctcct ttaaagcggg cttgatttga tcaagagagt tcataattga accgatttgg 1088641 tccataatat gcatgtaatt aatcgtctct tcgtcgtttg tctgagaaac ctgagaaact 1088701 tcctcttgct gttcctcctc cttctcttct gttggttttg ctgcatcgcc gaacatcatt 1088761 cttgaaaaca catccaactg catacgcctc ctttccatat accatactct atgagtaaga 1088821 tgaactgata gtttagacga atatattgcc atgtgaaaaa aaataggata gaattagtac 1088881 ctgatactaa taattgatca caacctgatt gatcttctaa atttaagata taaaggagtc 1088941 ttccctaatg aaagctggaa tacttggtgt tggacgttac attcctgaga aggttttaac 1089001 aaatcatgat cttgaaaaaa tggttgaaac ttctgacgag tggattcgta caagaacagg 1089061 aatagaagaa agaagaatcg cagcagatga tgtgttttca tcacatatgg ctgttgcagc 1089121 agcgaaaaat gcgctggaac aagctgaagt ggctgctgag gatctggata tgatcttggt 1089181 tgcaactgtt acacctgatc agtcattccc tacggtctct tgtatgattc aagaacaact 1089241 cggcgcgaag aaagcgtgtg ctatggatat cagcgcggct tgtgcgggct tcatgtacgg 1089301 ggttgtaacc ggtaaacaat ttattgaatc cggaacctac aagcatgttc tagttgttgg 1089361 tgtagagaag ctctcaagca ttaccgactg ggaagaccgc aatacagccg ttctgtttgg 1089421 agacggagca ggcgctgcgg tagtcgggcc agtcagtgat gacagaggaa tcctttcatt 1089481 tgaactagga gccgacggca caggcggtca gcacttgtat ctgaatgaaa aacgacatac 1089541 aatcatgaat ggacgagaag ttttcaaatt tgcagtccgc caaatgggag aatcatgcgt 1089601 aaatgtcatt gaaaaagccg gactttcaaa agaggatgtc gactttttga ttccgcatca 1089661 ggcgaacatc cgtatcatgg aagctgctcg cgagcgttta gagcttcctg tcgaaaagat 1089721 gtctaaaact gttcataaat atggaaatac ttctgccgca tccattccga tctctcttgt 1089781 agaagaattg gaagccggta aaatcaaaga cggcgatgtg gtcgttatgg tagggttcgg 1089841 cggaggacta acatggggcg ccattgcaat ccgctggggc cgataaaaaa aggtgaggtg 1089901 cacacaagat gactaaaaaa agagtagttg ttacaggact tggagcatta tctccacttg 1089961 gcaacgacgt cgatacaagt tggaataacg caatcaacgg tgtgtccgga atcggtccga 1090021 tcactcgtgt tgacgctgaa gaatatccgg caaaagttgc cgctgaatta aaagatttta 1090081 atgttgaaga ttatatggat aaaaaagaag ccagaaaaat ggaccgcttt acacaatatg 1090141 cggttgtggc tgcgaaaatg gcggttgaag atgcagatct taacattacc gatgagatcg 1090201 cgccgagagt cggtgtttgg gtaggctccg gtatcggagg acttgaaaca ctagagtctc 1090261 aatttgaaat cttcttaaca aaaggcccaa gacgggtaag cccgtttttc gtgccaatga 1090321 tgattcctga catggcgaca ggccagattt ctattgcatt aggagcaaaa ggggtgaact 1090381 cttgtacggt tacagcatgt gctacaggaa cgaactccat cggtgacgcg tttaaggtta 1090441 ttcagcgcgg tgatgcagac gtgatggtca caggcggaac agaagcgccg ctgacaagaa 1090501 tgtcattcgc cggctttagt gccaacaaag cgctgtctac taatccagat ccgaaaacag 1090561 cgagccgccc gtttgataaa aaccgtgatg gctttgtcat gggggaaggt gcagggatta 1090621 tcgttcttga agaacttgag catgccctgg cccgcggcgc taaaatttac ggagaaattg 1090681 tcggctacgg ctcaaccgga gacgcttatc atatcacagc gccggcccaa gacggtgaag 1090741 gcggagcgag agcgatgcaa gaagccatta aagatgcagg cattgcacct gaagaaattg 1090801 attacatcaa tgctcacggg acaagcacgt attacaacga caaatacgaa acaatggcga 1090861 ttaagaccgt ttttggcgag catgcgcata aacttgcggt aagctctaca aaatcgatga 1090921 caggccacct cttaggagca gccggcggta ttgaagccat tttctctatc ctggccatta 1090981 aagaaggcgt gattccgccg acaatcaata ttcaaacacc tgacgaagaa tgtgatttgg 1091041 attatgtgcc tgatgaagcc cgcagacagg aacttaatta tgttctcagc aactcattag 1091101 gattcggcgg acacaacgca acattaatct ttaaaaaata tcaatcataa tcaagccaaa 1091161 ccggctgccc ttaaagggta gccggttttt tttgtgtgca taggattaaa agaggaggcg 1091221 atcacatgag tgtagaacaa acatatagct ggctcaggaa ggccggttca atagatgatt 1091281 tggcgcatta cattatcccg cttttttcag gtgcggagaa aaagaactgg aagggcattc 1091341 tggggcatct tcagcatcat gggatgttta aaaacataaa agagggtatt cagacggttt 1091401 ccaagctgaa ggaaaaaggt ttttacggac atatccaaaa ggaagaacag tacctcaaaa 1091461 acaaatggca aggtcctgat gtaccaattg ttacgctgcc ggttgatgaa cgaaacagga 1091521 gaatccgttt agaattcgga tcaaaatcag gactcgcctt tcaagacaaa atgttccttt 1091581 ttctttcgtc agatttagat tttgggtcgg tatctgccct tatgacgcat gagtatcatc 1091641 acgtttgccg gttaggtcat ctgacaaaag aggaaaagga tgtcacatta cttgatacaa 1091701 tcatcatgga agggctggcg gaatatgctg tttatgagag gttcggccga agtcaaacgg 1091761 ctgaatggac gacttggtat acaccggaac agcttcaggc tttatatgaa aaaaagattg 1091821 cgccccatcg ggatatcaaa cgggataatc gattatttcc ccagctgtta ttcggcaaag 1091881 gatatcagcc aaaaatgctt ggatacgcag ttggattcaa tattgtaaaa aaatatttaa 1091941 ccgccagcaa ggcaagcacc gcagacgggc tgtccattcc tgctgagacc tttttggatg 1092001 caatgcttta aaaggataaa ataatggaat ttcattaata atattacatt tatcctaaaa 1092061 aattcttgat tttgcaaaat gattgtaata atatacaact ataaaatttt tcgataattc 1092121 aatattattt attatttctg aataaaggga ttgctttctc ttgaaaacgt ttgacaacaa 1092181 gaggggggaa aggggagcta gcatgagcac acttttagaa gtgaataatt taaagactta 1092241 ttttttcagg aaaaaggagc cgatccctgc ggttgacgga gtcgattttc acatcagcaa 1092301 aggcgaaacc gtcgcgcttg taggtgaatc gggctccgga aaaagcatta cttctttatc 1092361 aattatgggc ctcgtccaaa gctcaggcgg aaaaatcatg gacggctcta ttaaactcga 1092421 agacaaagac ctcacctcat tcactgaaaa cgattattgc aaaatccgcg gtaacgaagt 1092481 atccatgatc tttcaggaac caatgacctc ccttaatccg gtgttaacaa tcggagaaca 1092541 aattaccgaa gtgctgattt accataaaaa catgaagaaa aaagaagccc gtcaacgagc 1092601 tgttgaactc ttgcagatgg tcggtttctc ccgggcggag caaattatga aggagtaccc 1092661 gcatcggctg tccggcggta tgagacagag ggtgatgatt gccatcgcac tgagctgtaa 1092721 tcctaaactg ctcattgctg atgaaccaac gacagcgctg gacgtgacaa tacaagccca 1092781 ggtgctggag ctcatgaaag atctctgtca gaagttcaat acatcgattc ttctcatcac 1092841 acacgactta ggtgtcgtgt ctgaagctgc cgatagagtg attgtcatgt actgcggaca 1092901 agtcgtagaa aacgccactg ttgatgactt atttttagaa ccgcttcatc cgtatacaga 1092961 aggcctgctt acgtcaattc ctgttataga tggagagatt gataaattaa atgcgattaa 1093021 aggcagtgtg cctacaccgg ataatctgcc gccggggtgc cgttttgccc caaggtgccc 1093081 gaaagctatg gataagtgct ggacaaatca gccttcgctt ttgacacaca aaagcggaag 1093141 aacggtgaga tgctttttat atgaggaaga gggtgccgaa caatcatgac agcagctaat 1093201 caagaaacaa tcttagagct tcgtgacgta aaaaaatact ttccgatccg gtcaggcctt 1093261 tttcaaagaa aagtcggtga tgtaaaagcg gtggatggtg tttcattttc gttaaaaaaa 1093321 ggagaaacac tcggaatcgt tggagagtcg ggctgcggaa aatcgactgc cggcagaacg 1093381 atgatcagac tgtacaaacc gacagagggc caaattcttt ttaaagggca ggatatttcc 1093441 aatctgtcag aggagaagct gcggaagagt gtccgcaaaa atattcaaat ggttttccaa 1093501 gatccatttg cttcgttaaa cccgagaaag accctgcgtt ccatcataaa ggagccgttt 1093561 aatacgcaca acatgtatac catgcgtgaa cgaaacgaaa aagttgaaga gctgcttgca 1093621 agagtagggc ttcacccgtc gtttgccggc cgttatcccc atgagttttc aggcggccag 1093681 cgtcagcgga tcggcattgc cagagcactc actttgaatc cagagctgat cattgcagat 1093741 gagccggttt ccgcacttga tgtatccatt caggcccaag tgattaactt gatggaggaa 1093801 ttacaggaag aatttaatct tacgtatcta tttatctctc atgatctgag tgtcgtccgc 1093861 catatcagcg acagagtcgg agtaatgtat cttggcaaaa tgatggaact gaccggcaag 1093921 catgagcttt atgacaaccc gcttcaccca tatacccaag cgcttttatc ctccgttccg 1093981 gttacaagaa aaagaggttc tgtcaaacgt gaacgcattg tcctgaaggg agaactgcct 1094041 agtccggcca acccgccaaa aggctgcgta ttccacacaa gatgtcctgt tgcaaaaccg 1094101 atatgcaagg aacaaatacc agaatttaaa gaagctgctc ccagccactt tgtggcttgt 1094161 cacctttata gctaatgttg cccgcacagc tttgagaggg ggtatgcaca ctacataaac 1094221 aacagcctag aagaacgaac atttcaagag ggggaatatc taatgaaaag acggaaaacc 1094281 gcactgatga tgctaagtgt attgatggtt ctggccatct ttttatcagc ctgctcggga 1094341 tcaaaatcaa gcaacagcag cgcgaaaaaa tcagcaggca aaccgcagca aggcggggat 1094401 ttggttgttg gttcaatcgg agaacccaca ctttttaact ctctgtattc taccgatgac 1094461 gcaagtacgg atattgaaaa tatgctgtac agctttttaa cgaaaacgga tgaaaaacta 1094521 aatgtgaaat tgtcactcgc tgaaagcatt aaagaattag acggcggcct tgcatatgat 1094581 gtgaaaatta aaaaaggcgt taagtttcat gacggaaaag aactgactgc agacgacgtc 1094641 gtatttacgt acagtgtccc tttaagcaaa gattacaagg gagaacgcgg ttcaacatat 1094701 gaaatgctga aatccgtaga aaaaaaggcg attacgaagt cttgtttaag ctgaaatata 1094761 aagacggtaa tttctacaac aatgcgttag acagcacagc tattctgccg aaacatattc 1094821 tcggtaatgt tccgattgct gatttagaag aaaatgagtt taacagaaag aaaccaatcg 1094881 gttcaggacc atttaagttt aaggaatgga agcagggcca atatattaag ctcgaagcga 1094941 atgatgatta ctttgaagga agaccgtatt tagatactgt gacgtataaa gtcattcctg 1095001 acgcaaatgc tgccgttgct cagctgcagg caggcgatat taatttcttt aatgtgcccg 1095061 ccactgacta caaaacggct gaaaaattca acaacctaaa aatcgttact gatttggcat 1095121 taagttatgt gtacatcggg tggaatgaaa aaaatgaatt attcaaggat aaaaaggttc 1095181 gtcaagcgct aacaaccgct cttgaccgcg agtcaatcgt cagccaagta ttagatggag 1095241 acggcgaggt agcttacatt ccggaaagcc ctttatcttg gaactatcct aaagatatag 1095301 atgttccgaa atttgagtac aacgagaaaa aagcgaaaca gatgcttgca gaagccggct 1095361 ggaaagatac gaacggtgac ggcattctgg ataaagacgg aaagaaattc tcgtttaccc 1095421 ttaaaacgaa ccaaggaaac aaagtccgtg aagacatcgc tgtcgtcgtt caggaacagc 1095481 tgaaaaaaat cggcattgaa gtgaaaaccc agatcgttga atggagcgct ctcgttgaac 1095541 aaatgaatcc tccgaattgg gattttgatg caatggtcat gggatggagt ttatccacat 1095601 tcccggatca atatgatatt ttccattcaa gccagattaa aaagggtttg aactacgttt 1095661 ggtataaaaa tgccgaagcg gataaactca tgaaagatgc aaaatcaatc agtgacagaa 1095721 agcagtattc aaaagaatat gagcaaatct atcaaaaaat tgcggaagat cagccgtata 1095781 cgttcttgta ttatcctaac aaccatatgg caatgccgga aaatcttgaa ggatacaaat 1095841 atcatccgaa acgtgatttg tataatattg aaaaatggtg gcttgcaaaa taaatttccc 1095901 ttaaagggga gggagagcgt tttctccctc ttctgttttt aataaggaaa gtaaaggggg 1095961 acaagtatat ggctgcatat attatcagaa gaaccttaat gtctatcccg attttattgg 1096021 gaattacgat tttatcattt gttatcatga aagccgcgcc cggagatccg atgacattaa 1096081 tgatggaccc gaaaatcagc caggctgaca gagagcagtt tattgaaaaa tacggtctga 1096141 atgatcctca gtacgttcaa tatttaaagt ggctaggcaa catggtgcag ggtgatttcg 1096201 gaacgtctat tgtcagaaaa ggaacgcctg tttcagaatt gattatggca agactaccca 1096261 atacgctcct gctgatgctg gtttcaacga ttttggctct tatgatttct attccgttcg 1096321 gtgtcctgtc ggcaaagcgg ccgtattcaa aaatcgacta tggcattaca tttacctcgt 1096381 ttataggcct ggctattcca aacttttggt ttggattaat tttgattatg gtgttatcgg 1096441 taaatctcgg ctggtttcca actgggggtg tcgagacact gaataccgaa ttcaatatat 1096501 ttgaccggat tcatcattta attctgcctg cattcgttct agctacagct gacatggccg 1096561 gactgacgag atacacgaga tccaatatgc ttgatgtatt aaatcaagat tatattcgca 1096621 cagcgagagc aaaaggattt aaagagaaca gagtgctatt taaacatgga ttgaggaatg 1096681 cattattacc cgtcattaca attttcggtt tgatgattcc ttcatttatc ggcggatctg 1096741 tcgttgtcga acaaattttc acttggccgg gattaggaaa gctgtttgtc gattcagcat 1096801 tccagcgcga ttatccggtt atcatggcaa tgactgtgat ctcggcggtt cttgtcgttg 1096861 tcggaaacct cattgcagac atcctttacg cgattgttga tccgcggatc gaatattaaa 1096921 aggagggaaa cagagatgtc agagctgcaa acaactccct cgccggagat caggctgaaa 1096981 gaaaatattt cgaaaaagcc agaaacaatg acaaagattt tctgggaaaa attctcgaaa 1097041 aacaaactgg ccattttagg tgccgttatt ctttttatca ttattatgtc tgctgttttc 1097101 gcccctttaa ttgcacctta tccccaagag cagcaaagcc tgcttgataa atataaggcg 1097161 ccgggccttg aacatctgat gggaacggat aaatttggac gtgatatttt cagccggatc 1097221 ctatatggag cgcgtgtctc tttattggtt ggatttgcgt ccgtagtcgg ttcgattttg 1097281 atcggaacgg ttttaggagc attagccgga tatttcagag gaatagtgga tgctgtcatt 1097341 atgcgtgtag ttgacattgt gttatccatt cctgatattt tcttgttgat cacgctggtc 1097401 accatcttca agccgggtgt ggacaaattg attttaattt tctgtctcac aggatggacc 1097461 acaacagcac gattagtaag gggagaattc ttgtcgctcc gttcaaggga atatgttctt 1097521 gctgctaaaa caattggaac aaaaacgcac aaaattattt tttctcatat cctgcccaat 1097581 gcgttagggc cgattatcgt gtcagctacg ctgaaagttg ggtctgttat tctagctgaa 1097641 tcggcgctaa gctacttggg ctttggaatc cagccgccaa tcgctagctg ggggaacatg 1097701 cttcaagacg cacagaattt cacagtaatg attcaagcat ggtggtaccc gttatttccc 1097761 gggctattta ttttaatgac cgttttatgc ttcaactttg tcggtgatgg cctgcgggat 1097821 gcgcttgacc cgaaaaatat taaataaaaa tgaatatcat atctgttata aaatatcacc 1097881 aaatcagaaa aaagcaggtc tcctttagtc agaaaatata caaagagatc tgctttttat 1097941 gattcttaca taaacccagt gattccagat ttcctcaatc tctttggaat aatttctcta 1098001 tcccttgcct atactgtgga caacagtttt tataaaagtg aggggttaga gatgttattt 1098061 cttcatgatg tgtgggtcaa ttggtttgaa ggggaagaaa atggctacaa tgtatgccac 1098121 tttcacgaat ggcgcaagga agatacggtt gagcttttgg atcaggtgcc gctgttaagg 1098181 gtgccgtcag tactgtttca ttacatagaa aacgatttgt cagagcttcc gaaaggtttg 1098241 cttgaagacg tacatcagaa atcgtacatt cgaaaaaatc atgagcggac aaagcttgag 1098301 tattgttttg tcgtaacaga cggaatcggc attttagctg ttgacacgat cggctacacg 1098361 atccctgtca gaaaaagccg tctaatccca agacaggagc agctcgttta tgaaatggta 1098421 aaagatgtag agcctgaaac atatgaattt gagccaaaga agctggaatc ctccaaggaa 1098481 tatcacatct tatcattagc accagaacat gtcagaggac tgacaagaaa agaacggcaa 1098541 attaagcagc tgatgtttat ggcgcttgac caattaaaag ggctgaaaaa ccgagcggaa 1098601 attggctact ggtacacaga gtggaatccg catatgtatg aacaaatcaa aaggatgagc 1098661 tttgaagaga tttgggacat gctgtataac gaaacaattg aaggctggtc ggacaaacac 1098721 ctagcttttt gcgaaaacct aataaaagga cagccttttt tcgaaaagct ttgggaaatg 1098781 gaaaacgaat caaaggtcaa ctgaaaaaaa ccgctctttg caaagagcgg ttttttgatt 1098841 agcgtctttt tcttccaaga cccatggcat tctccatttt tttcagcatt ttgtttgctg 1098901 tccgattcgc tcgttccgcg ccttcatcaa gaatccggtc taattcttca gattctatca 1098961 gctcgtaata gcggtcctgg atcggtttta atgcgttcac tacgacttct gccaaatcac 1099021 ctttaaactc gccgtagcct tttccttcgt actttgcttc aagctcttca attgtcgtat 1099081 tgccgaggat tgaataaatt gtaagaaggt tggaaacgcc cggtttgttt tccttatcaa 1099141 atttgacaat gccttcagaa tccgttactg cgcttttgat tttcttttca agctgcttcg 1099201 gctcatccag caatgtaata taagctttct gattcggatc agatttgctc attttcttca 1099261 gcggatcatt cagagacatg atacgtgcac cgacttttgg aattttcact tccggaatcg 1099321 taaagatgtc gttgtatttt ttgttgaagc gttctgcaag attccgcgtc agctcaaggt 1099381 gctgcttttg atcctcgccg acaggtacaa gatccgttcc gtacagcaga atatcagcgg 1099441 ccatcagcgg cggatatgtt aacaggccgg agacgacagc ttcattgcct ttggatttgt 1099501 ccttaaattg agtcatccgc tcaagctcgc cgatataggc gacacactgc atcatccatc 1099561 cggcctgcgc atgtgcgggg acctctgact gaataaacaa tgttgctttt tctggatcaa 1099621 gtccgacagc taagtaaagc gccgcgagat tgcggatatt ctttctaagc tcaagccggt 1099681 cttgaggaac agttatcgca tgctgatcga cgatgcaaaa atagctgtta taatcatgct 1099741 gcagttcgac aaactgcttc attgcaccga tatagttgcc gagcgtcact gagccgcttg 1099801 gctgaatgcc tgaaaaaatc gtttgtttca tgaaaacatc aacctcattt cttaaaacat 1099861 aataaaaaag gctcattctt cccctgtaaa aaagggacga atgaaccgtg gtaccaccct 1099921 gattattcca ttaaaatgga atcactctga cgtttgtaac ggagactgct ccggctgagc 1099981 ctactttttt ccagttcggt cagctgctcc aaagtccatt ccacattgcc cgttatctgc 1100041 tcccagcacc gcagactctc ttcaaacagg tgaaacgtgt actactcttt ttcatagcaa 1100101 gcttttcttt tgattgcttc attataaatc aattataacc aattgtcatc atgaaaaaac 1100161 attctttttt ccagtaaaat tgtaataata taaataacac gagtgctgta aaatccttaa 1100221 atgataactg ctatcagcgt aaaaacaggc agatattata tgtaaaaagc aatatgggca 1100281 gaaaacacat gaaaaagttt ttaatcaatt tatgctttaa atggtagaag gatattatgt 1100341 tcatggaaga aaaactaacg aagtttaaat attttaaatt gataaaataa tattgcaata 1100401 aattatttgt ttcattataa tgaacttgtt cactctattg ttacagcttt tttacaaaaa 1100461 taatcagaaa agacggaaca gaataaaagt tgtggaaact caggttcatt tgtctgatat 1100521 ttctgaggat ttagccgtaa ggagctgaaa attattatta gggggtttgc gaatatgaaa 1100581 aaacgttggt cgattgtcac gttgatgctc attttcactc tcgtgctgag cgcgtgcggc 1100641 tttggcggca gcggatcaaa cggtgaaggg aaaaaggaca gtaaaggaaa gacgacactt 1100701 aacattaata ttaaaactga gccgttctcc ttacatccgg gattggcaaa tgattcagta 1100761 tcaggcggtg ttatccgtca gacttttgaa ggattgacac gtatcaatgc agatggtgag 1100821 cctgaagaag gcatggcttc taaaattgaa acgagcaagg acggaaagac atatacattt 1100881 accattcgtg atggtgtgaa atggtctaat ggagaccctg taactgcaca agattttgaa 1100941 tatgcttgga aatgggcgct tgaccctaat aatgaatcac aatacgctta ccagctctac 1101001 tacataaaag gtgctgaagc ggcgaatacc ggaaaaggca gcctagacga tgtggcagta 1101061 aaagctgtga atgacaaaac gctgaaggtt gaattaaata acccgactcc atatttcact 1101121 gaattaactg cgttctatac gtatatgccg atcaataaga aaattgcaga gaaaaataaa 1101181 aagtggaata caaatgccgg agatgattat gtatcaaacg ggccgttcaa aatgacggca 1101241 tggaaacaca gcggctctat tactctcgaa aaaaatgacc agtattggga taaagacaaa 1101301 gtcaaactga agaaaatcga tatggttatg atcaacaata acaatacgga actaaaaaaa 1101361 ttccaagctg gcgaacttga ttgggccggt atgccgctcg gacagcttcc gacagaatcc 1101421 ctgccgaccc tgaaaaaaga cggttcttta catgttgagc cgattgcagg agtgtattgg 1101481 tacaaattca acactgaagc taagccatta gacaacgtca atatccgtaa agctttaaca 1101541 tattcgcttg accgtcagtc gattgttaaa aacgttacgc aaggagagca aatcccggca 1101601 atggctgcag tgccgcctac aatgaaggga tttgaggata acaaagaagg atacttcaaa 1101661 gacaatgatg tcaaaacagc aaaagaatac cttgaaaaag gcctaaaaga aatgggctta 1101721 agcaaggcat ctgatttgcc aaaaatcaaa ttgtcttaca acactgatga cgcacacgcg 1101781 aaaatcgctc aagcagtaca agaaatgtgg aagaaaaatt taggcgttga tgttgagctt 1101841 gataactcag agtggaatgt ctatattgat aagctccaca gccaagatta tcaaatcggc 1101901 cgtatgggct ggctcggcga cttcaatgat cctatcaact tccttgaatt gttccgcgac 1101961 aaaaacggag gaaataacga tacaggctgg gaaaatccag aattcaaaaa gcttctgaat 1102021 cagtcacaaa ctgaaacaga taaaacaaaa cgtgcagagc tgctgaaaaa agcagaaggt 1102081 attttcattg atgaaatgcc ggttgcccca atctatttct atactgatac ttgggtacag 1102141 gatgaaaacc taaaaggtgt tatcatgcca ggtactggtg aggtttattt cagaaacgca 1102201 tattttaaat aaggctacgt ctgaaaataa aagacctcaa ggtatatggg gagaaaagcc 1102261 ccatatacct ttcttactga tggagtataa aaatgtaaaa accatggagg tgttccccct 1102321 tgctaaaata tatcggaaga cgcttagtct atatgattat cacactattt gtgattgtaa 1102381 ctgtgacatt cttcttaatg caagcagcac cgggcgggcc attttcaggt gagaaaaagc 1102441 ttccgcctga aattgaagca aatttaaatg cgcattatgg cttggacaag ccgctgtttg 1102501 tacaatatgt cagttatttg aaatcagttg caatgtggga tttcggaccg tcatttaaat 1102561 ataaaggtca gagtgttaac gacctgatca gttcaggttt ccccgtttca tttactcttg 1102621 gagcagaagc tattctcctc gctttagcgt taggtgtatt gtttggggtc attgcagccc 1102681 tttaccataa taagtggcag gattataccg tcgcgatttt aacgatattt ggtatttcgg 1102741 ttccgagctt tatcatggcg gctgttctgc aatatgtgtt ctccatgaag cttgggctgt 1102801 ttccggtcgc ggggtgggat tcctgggcat acaccttttt gccttccatc gcacttgctt 1102861 ccatgccgat ggcgtttatt gccagacttt cccgttcaag catgatcgaa gtgttaaaca 1102921 gtgattatat ccgcacagcg aaagcgaaag ggctttcccg cccagcggtt acagtgcggc 1102981 acgccattcg aaacgcactt ttgccggttg ttacatatat gggcccgatg gccgcacagg 1103041 tcttaacggg gagcttcatt attgaaacca tttttgggat tccggggctt ggtgcacact 1103101 tcgtcaacag tattacaaac cgtgattata cggtcattat gggtgtaacg gtgttcttca 1103161 gtgtcatctt gctattgtgt gtattaatcg tagatgtgtt atacggcatt attgatccaa 1103221 gaatcaagct ttccaaagca aagaaaggag cctaggccat gcagaacatt ccaaaaaaca 1103281 tgtttgaacc agccgcagcg aatgccggcg atgcagaaaa aataagtaaa aagagccttt 1103341 ccctctggaa agatgcgatg cttcgcttcc gcagcaataa gcttgcaatg gtcgggctta 1103401 tcattatcgt acttattatc cttatggcaa tttttgcgcc gatgttctca aggtatgatt 1103461 attcaactac taatctctta aatgcggata agccgccttc aaaagatcac tggttcggaa 1103521 cagatgatct tggacgggac attttcgtcc gtacatgggt aggggcgcga atctcaatct 1103581 ttatcggtgt tgcagctgct gttctcgatt tgctgatcgg cgtcatttgg gggagcattt 1103641 caggcttccg cggaggaaga acagatgaaa tcatgatgcg tatcgctgat atcctttggg 1103701 cagttccttc attattaatg gttatcttac tgatggttgt tcttccgaaa ggtctattta 1103761 cgattattat tgccatgacg attacaggct ggattaatat ggccagaatc gtgcgcggac 1103821 aagtgctgca gctgaagaat caggagtatg tgcttgcttc acagacactg ggtgcaaaaa 1103881 catcccgtct tctatttaaa catatcgtgc caaacgcaat gggttctatt ttggtcacga 1103941 tgacactgac agttcctact gcgattttta cagaagcctt tttaagctat ttgggacttg 1104001 gtgttccggc tccgctggca agctggggaa cgatggcttc tgacggattg cctgcattga 1104061 cctattatcc gtggcgttta ttcttccctg ccggatttat ctgcattaca atgtttggtt 1104121 ttaacgttgt cggcgacgga ttaagagacg cattggatcc taagttacgt aaataaggga 1104181 gtgatacggg tgacacgcct attagaagta aaagatttag caatttcatt taaaacatat 1104241 ggcggagagg tccaggcgat ccgcggagtg aatttccatc tggataaagg ggagacgctg 1104301 gccattgttg gagaatcagg ttccggaaaa agtgtaacct ctcaagcgat tatgaagctg 1104361 attccaatgc ctccgggtta tttcaaacgc ggtgagatcc tgtttgaagg aaaggatctg 1104421 gtgccgctgt ccgaaaaaga aatgcaaaat gtccggggaa aagagatcgg catgatattc 1104481 caagatccga tgacctcttt aaatccaacg atgaaggtcg gtaaacaaat tacggaagtg 1104541 ctttttaaac acgaaaagat ctcgaaggaa gcggctaaaa aacgcgcggt tgaactgctg 1104601 gaattagtcg gtatcccaat gccggaaaag cgggtgaacc aatttccgca tgaattttca 1104661 ggcgggatga gacagagggt tgtcattgcc atggcgcttg cagcgaatcc gaaacttctg 1104721 atcgccgatg agccgacaac tgctcttgat gtaacgattc aagcgcaaat tttggaatta 1104781 atgaaggatt tgcaaaagaa aattgacacg tccatcatct ttatcacaca cgatcttggt 1104841 gttgtggcta acgttgctga ccgggtcgct gtcatgtacg cgggacagat tgtagaaact 1104901 ggtacggtag acgaaatctt ctacgacccg agacatccgt acacttgggg gcttcttgca 1104961 tccatgccga cactggaaag ttcaggagag gaagagctga ctgcaattcc gggcacgccg 1105021 cctgatttga caaacccgcc aaaaggagat gcttttgccc tgcggagctc ttacgcgatg 1105081 aaaatcgatt ttgaacagga gccgccaatg tttaaggtat ccgatactca ttatgtaaaa 1105141 tcgtggctgc ttcatcctga cgcgccaaag gtagagccgc ctgaagcggt aaaagcgaaa 1105201 atgcgtaaac tggcaaacac gtttgaaaaa cctgtcttag tgagagaagt tgaatgaatt 1105261 gactgaaaaa ctattagaaa tcaaacattt aaaacagcac tttgtcacgc cgaggggaac 1105321 ggttaaggct gtagatgatt tatcatttga tatctataaa ggtgaaacat tagggctggt 1105381 tggtgaatct ggctgcggta aatcgacaac aggccgaagc attatcaggc tgtacgaagc 1105441 aaccgatggt gaggtgctgt tcaacggcga aaatgtgcac gggagaaaat cgcggaaaaa 1105501 gctgctggaa ttcaaccgca aaatgcagat gattttccaa gacccctatg catccctgaa 1105561 tccgagaatg acagttgctg atattattgc tgaaggcctt gatattcata agctggcaaa 1105621 aacgaaaaaa gagcggatgc agcgagttca tgaactattg gaaacagtgg gattgaacaa 1105681 ggaacacgcg aaccgctatc ctcatgaatt ttccggcggc cagcgccaaa gaatcgggat 1105741 tgccagagcg cttgctgttg atccggaatt cattatcgcg gatgagccga tttccgcttt 1105801 ggatgtatcc attcaagcgc aggtcgtgaa tttaatgaaa gaactgcaaa aagaaaaagg 1105861 gctcacatac ctgtttattg cccacgattt atcgatggtc aaatacatca gtgaccgcat 1105921 tggcgtcatg tatttcggga aactggttga gcttgcgccg gcagatgagc tttatgaaaa 1105981 tccgcttcac ccatatacaa aatcattgct ttctgcgatt ccgcttcctg atccggacta 1106041 tgagagaaat cgcgttcgcc agaaatatga tccgtctgtc catcaattaa aggatgggga 1106101 aacgatggaa ttccgtgaag tcaaaccggg acattttgtg atgtgcacgg aagccgaatt 1106161 taaagctttt tcatgattca tcaatccttc aagagatttc tcttgaagga tttttttgcg 1106221 tcttcataga aagtgagaat gataacattt acaattagag gaaaaagcgg aggcgaaata 1106281 cgattcaatt tctgcataac aaaaatgttt ttgcgctatt gctgtctcaa tcttttcaat 1106341 ctttagcagg agtcctcgtc acaatcgttt taatggtccg gatctatcaa atgactgact 1106401 ccgttttttt ggcgggcctt attttatcgt tcatgtcgtt tgcgagtata gcagcaagct 1106461 tttgcgtctc tccggtgctt cgcattctcg gttttaaaaa ggtgcttgcg ggagcgaatc 1106521 tgctgagagc ggtctttatt atactgatgg catacagcgt cactcatcac ggacaggcat 1106581 tcttttggat tacgctgctg tttgtgtttt gtttttcctt cgcgggcgct ttttttcagc 1106641 cggcaagatt tgcgctgctg ccgattattg ttccaaagaa gcaatatgta aaagcgaatg 1106701 gtgtgatctc cctctcgaat caattgttct taacagcagg ctggggcctt ggaggccttc 1106761 tgacgtacgc cgtccctttt gaactcgttg tcggcgctgc catttgcctg tttgttctat 1106821 cgggagcttc catcagtgtg ctgcatgtaa atgaagaaga ggctgcagga actgctgaaa 1106881 cagcatctgt cagaagtata tggaaggatt taatgatcat ccctattgta agagacatta 1106941 ctgtaatgga catgttagaa gctttggcgg gttccgtatg gtcatctgct attctcctcg 1107001 catttactgc ggctgttttg catgaaacag aggtgtggtg ggggatgttt aacgcttcct 1107061 attttatagg cgcaattgtc ggcagtgtga ttgctattcg tttttcttct ttttttgagc 1107121 ggaatatggg ctatgccatt atgttcagct cgcttgtaat gtcggcgctg acccttttgt 1107181 tttcattttc tccagtccca tttttatgcg ctctggcttg tgctgcaatg gggccttttt 1107241 atcaggtgcg tgatatttgc caggaaacca tgctgcagga agttattccc gagcagaaac 1107301 gaatcggaat catggctgca aaaaatgcga ttttgactcc ttggtcaggc gtcacctact 1107361 ccattatggg gctagtggct gatgctgctg gtgcgaaaat agcttttatc gcggctgctg 1107421 cattatatat catgacattt ctgattgcac tggcgcagcc ccgtctggtt cattacaggc 1107481 gagaaaatcg agttcaatga gaaacacttc aaaatgaacg gagcagctgg ctccgttttg 1107541 ctgaaaaaaa aatgaaacca tggcggaagt tcgcacgtct ttatagatgt aaggctgttt 1107601 aaacaagaag aaatggggta tatctaaaag tatgaagaca acgaactcat aaggagcaaa 1107661 tcaatgaact ggtatgaaaa gcttagcgag tactttccaa ttgaagaaat gaaatcaaaa 1107721 gcgcatatgg aagctcttct gaaagagcga agcgatattt atcataaaga tgaaggcaaa 1107781 catcatattt taatgtttgc ggaattcgat tcttttatct tcgttgatta tctgtatgtg 1107841 tctaaggatg caagagggca ggggcttggc ggcaaattga tcgcgaagct gaaaaagaaa 1107901 aataagccca tattgctcga ggtggaacct gtggatgaag atgatactga tacagaaaaa 1107961 cgcctgaggt tttatcaaag agagcatttc aagcatgctc agtcaattgg gtaccggcgc 1108021 cggtcattgg ctacgaatga agtaaacaag atggagattc tgtactggtc accaaaaaca 1108081 gaatcagaag aagaaattct tgaagccatg aaacagacat atgaaaacat tcatacttat 1108141 aaagatgaga aatggtacgg agaatcgtac gaaaaaacgg atgaggtctt ggaaatcatc 1108201 gatgaagaaa aacaaaaaaa tattttcgat cagttaagct aattgagaat aagaacatat 1108261 catgaacatt aaaaatttgc tggattgaca catttttttc ttaggatact gttcacactt 1108321 acttttttat agtataatac ctgtaaagat tcctttttta gagtaatttc aatttaagaa 1108381 taaaatagat gttcatccta ctaattagag gagtgaagat gaatggttac actatacaca 1108441 tcaccaagct gtacttcatg cagaaaggcg agagcgtggc tcgaggagca cgagattcca 1108501 tttgtagaaa gaaacatttt ctctgaacct ttatcaattg atgaaataaa acaaattctt 1108561 cgaatgactg aggacggaac agatgaaatc atctcaaccc gttcaaaagt attccaaaaa 1108621 ctgaatgtga acgttgaatc tatgccgctg caagatttgt accgcttgat caacgagcat 1108681 ccaggtttgc ttcgccgtcc gatcatcatt gacgaaaaac gtttgcaggt cggatataac 1108741 gaagacgaaa tcagacgttt cctgccaaga aaagttcgct ctttccaatt aagagaagca 1108801 cagcgtttgg caaactaata gatcgtatca tcaaaagaag gctgagtcat cagccttctt 1108861 ttatttttca acctgctggt aataaatgct cgcaaggatg acaaacgcaa ccgtcaaaat 1108921 ggggaggagc gtttcgactg tgccgtgctg cgccataaaa agcgacagct ttttgtctct 1108981 gacaatcatt tctccgccag tataagcaag cagcccgctt cccgcgtaaa tcagaagcgg 1109041 tattttctct agtgcaatat ggatgagttt gctgccccaa ataataaccg gaaccgatac 1109101 acacaatcct ataacaacga gagaaaactc accgtgtgaa gctcccgcaa ctgcgatgac 1109161 gttgtccagc gacataaaga gatctgcaag cacaatcgtt cgtatcgctc tccacaggga 1109221 ggtgctgctt ttaatgtgtt tcgtgtcttt tttttcaatc agcagctgat atcctaaata 1109281 cagcaggaaa attccgccgg cgcactgcaa gaacggaatg ttcaaaagat atactgctgc 1109341 acttgttaat ccgattctca tggcaacggc aataaatgtt ccgagaataa tggcttgctg 1109401 tctttgcttg tccggcaaat gtctgctggc catggcaata acaaccgcgt tatctccgcc 1109461 gaggatcagg tcaatcccaa caatgacgag cagagaaatc agatagtcat gctccatgaa 1109521 gcggcacctc gctttcagtc cttcgcttgt actactacta tatgagacag gtcatatttt 1109581 atgatatcag ccgcctgatc tgccgttttt taggcaaagg tgcattttta tttcttttgt 1109641 gactgtttta tcataaaata gaaatacaaa ggaattcaca ctggccttgg ttaaggttaa 1109701 gatgtggacg gaatgggtaa agtgtagtaa agtacaatta atcgggagct tagatgtccc 1109761 ttcaacatct tatatagaag ggaaggttgg caaatggaaa ttgaaagaat taacgagcat 1109821 acagtaaaat tttatatgtc ttacggagat attgaagatc gcggttttga cagagaagaa 1109881 atttggtata accgtgagcg cagtgaagaa cttttctggg aagtcatgga tgaagttcat 1109941 gaagaagagg aattcgctgt ggaaggccca ctttggattc aagttcaggc actggacaaa 1110001 ggattagaaa tcatcgtcac aaaagcccag ctttccaaag acggacaaaa gctcgaactg 1110061 ccgattcctg aggataaaaa gcaagaacca gcatctgagg atcttgacgc cttgctggat 1110121 gatttccaga aagaagagca agccgtcaat caggaagaga aggagcaaaa gcttcaattt 1110181 gtcttgcgat ttggcgattt tgaggatgtt atttctctat ctaaattgaa cgttaacgga 1110241 agcaaaacga ctttatattc gtttgagaac cgatattatt tatatgtaga tttttgcaat 1110301 atgactgatg aagaggttga aaatcagcta agcatcctgc tggagtacgc aactgaatcc 1110361 tcaatcagca tacaccgtct tgaagagtac ggcaagctga ttatttcaga gcatgctcta 1110421 gaaacgataa aaaaacactt tgcatcatag caaaccgatt tccttccgga aatcggtttt 1110481 ttttatgcac gaaaatgcca ttttagagat gtgaaaaatc aaaaacatat agacaagcag 1110541 aaaatacagc gaacaggagt tgatcatctt ttccagaaag tatacttcat ctggaaagga 1110601 gagatgacaa ttgtttagtg ctgtgactga agacggccaa atgtttcacc ttctaggcgc 1110661 tcagcaaaac cagaaattaa agcggagacg gttcttctgt ccggtatgcg ggggagagct 1110721 agctgtgaag ctcggacttc aaaaagcgcc gcattttgcc cataaacaga acaagtcctg 1110781 cgccatagac atcgagccgg aaagcgccta ccacttagaa ggaaaaagac agctgtatgt 1110841 atggctgaaa acgcaacggg cttcaccaat attggagccg tatataagga caatcaacca 1110901 aagaccggac gtcatggcaa gaatcaagga gcatatgctt gctgttgaat atcaatgcgc 1110961 cactatcgct ccagatgtct ttcaaaagcg gacagagggc ttcaaacaag aaggaatcat 1111021 cccgcagtgg attatgggat acagccgctt aaaacggact gcttcgtcct tttatcagct 1111081 ttcaactttt cattggcagt ttatcaatgc aagtccatac agagaactga tatgttattg 1111141 tcctgaaagg cgttcttttc tccggctcag ccacatcatt ccattctaca caaaccattc 1111201 ttattcctca gtccaaacga tccctatcca tcgggcaggt gcaggcgatc tttttttcac 1111261 tgaaccgaaa ccctcaattc aatattcagg ctggacgaaa gcgattcacc gttttcgcca 1111321 taaaccccat cggtttaact caaaggaaac aaatcgcctt aggctgctgt tttatgagaa 1111381 acgacagacg cctttttctt ttctgccgac tgaagtgttt gttcctgtta gaaaaggggc 1111441 agtttttaag agtccggttt ttgtgtggca ggggtttctt tatttgttta tgacggatct 1111501 tggaggtaaa cgtgcgccaa ttcgtttttc agccgttttg cagcagtgca aactgcacat 1111561 tcataataag aacattgcac tcaggtccga atgcagcgaa gagtgtcttt cagaagcggt 1111621 taaacagtat attgattttt tgtgcaagaa gggattttta agggagactc agaaagaagt 1111681 atatgtgctg aatcagcctg caggaggcat acactccatg caggatctca tagaaagaga 1111741 ccgcagctgt tttatagaat gagtttgtct tatttggctc accctaagac aaaggtggtg 1111801 ggcaggctgt gaaaggcaca aaaggaaagg tttttcgtgt ttttactgct tttttggcat 1111861 tcgttctctt cattactgca tatgatttga caaaaggcag tgaaaaaccg gaagatattc 1111921 acaacacaag tttattgaga aacagctgtt ttttcaattg gcttgaatca aagaagacga 1111981 gggggatcac catggctgag gaaaaaaaag caaaccaact gcctgacaga agtgaggtaa 1112041 aggcagaaga cacatggaga cttgaggata tttttcctag tgatgaggcc tggaataaag 1112101 aatttcaagc tgtaaaagaa ttaattccga atttatctaa gtataaagga aagctggcag 1112161 attcagctga tcatttatac gaggctctta cgtatcaaga taaagtgatg gagcggctag 1112221 gtaggctgta cacatatgcg catatgcgct ctgaccagga tactgggaac tccttttacc 1112281 aggggctgaa tgacaaggcg ggaaacctgt atacacaggc cgcaagcgcg acagcttatt 1112341 tggttccgga gattttatcc atagaagaag acaaactgca gcagttcatt cttgaaaaag 1112401 aagaattgaa gctgtactct catgcgattg aggagattac aaaggaacgt ccgcatgtgc 1112461 tgagcgagaa ggaagaggcg ctgcttgctg aagcctccga ggtactgggg tcatcttcaa 1112521 atacattcag cgtgttaaat aacgcagata taacgtttcc atccattaaa gacgaagatg 1112581 ggaatgaaaa acagatcact cacggcaact ttattaattt cttggaaagt gaaaaccgtg 1112641 aagtccgcaa aaatgcgttt gacgcagtgt ataaaacgta cggacaatat aaaaacacaa 1112701 tggccacgac gctaagcggc actgtgaaaa aggacaactt ctacgcgaga gtgaaaaagt 1112761 acaagtccgc gcgtgaggct gcgctttcta acaacagtat tcctgaggaa gtatacgata 1112821 accttgttaa gacgattaat aagcatttgc cgctcctgca ccgctatatt gcgctaagaa 1112881 agaaagtgct tgagcttgat gaagtgcata tctatgacct gtatacaccg cttgtgaaag 1112941 atgctgggat gaaggtgaca tacgaggaag ccaaagatta catgctgaaa ggcctcgcac 1113001 ctttagggga agaatatgcc tctatcctaa aagaaggact ggaaaaccgc tgggtggacg 1113061 tttacgaaaa taaaggcaaa cgcaatgggg cttattcatc aggagcttac ggcacgaatc 1113121 cgtatatttt gatgaactgg cataataacg tcaataatct ctttacgctc gtgcacgagt 1113181 ttggacattc cgtacacagc tactatacga gaaagcacca gccttatcca tacggcaatt 1113241 acagcatctt tgtcgcggaa gttgcctcta cgacaaatga agcgctcctt ggcgaatatt 1113301 tgctgaacaa tttagaggat gaaaaacagc gcttatatat tctcaaccat atgcttgagg 1113361 gcttcagggg aacggtcttc agacaaacga tgttcgctga atttgaacat ctgattcata 1113421 caaaggcgca agaaggcgag ccgcttacac ctgagcttct gacaaatgtc tattacgacc 1113481 tgaataaaaa gtattttgga gacggcatgg tgattgataa ggaaatcggc cttgaatggt 1113541 cgcgtattcc gcacttctat tacaattact atgtgtatca gtatgcgaca ggttacagcg 1113601 ctgcccaagc attaagcagc cagattttga aggaaggaaa gccggcggtt gaccgttata 1113661 ttgacttcct gaaagcggga agctcacaat acccgattga tgtcctgaaa aaagcgggtg 1113721 ttgatatgac gtctccagag ccaatcgaag ccgcgtgcaa aatgtttgaa gaaaaacttg 1113781 atgaaatgga agagctgctg atgaaagtca agcagtctta aaaaagtaag cctgtgcgga 1113841 aatgacgcac aggctttttt aaaacccttt aaaggttttc cggtgattca agcggtagag 1113901 ggtaaacaaa atagacagaa acagcagagg agaggtaata taaagcggca gcatatgcat 1113961 catgcctaag atattcaagc agaaaaaaac agcaatgcac acaattgaga tcaaagtaga 1114021 catcatggcg gtcctcctcg tcctttttcc ttataaggat atgagtgaat gcacttcgtt 1114081 atgttttgtg acaaaaatat gaacattaag catagaggtt gtcaaaagtc gacatctttt 1114141 gttatcataa ggatgtgaaa ttgatcacaa acaaacatta cccctttgtt tgaccgtgaa 1114201 aaatttctcc catccccttt gttgtcgtta agacatatga aaccgcgctt atcccggcgc 1114261 ggtttcttta gtgctaaaaa tggaacgtac gtttggttat ggcataaaaa aacagcctca 1114321 agcatatgca cgcctgcggc tatttttcac atgattgata ttcatcagaa taagtgctga 1114381 gagacttcca aaacattccg tgtttggctt ccactttggc aaccttttta gcaaacgcca 1114441 gttttttcat ttctttttct acctcttcaa ggctcaggtc atatacaaga gcaatttcct 1114501 tcgaggcaac gaagcggaaa tattcaataa aacattctaa aggcggtgtt tccgacggct 1114561 tcggctcgtc gccaagcatc tcaaataaaa tttcttcata tacatcatat gagtagctgc 1114621 caggaacttt aagcccttca tcctcatgct gcgtattaaa aaacgtcagt gtcggattaa 1114681 cagaaacatc catctcggca gcaattttca tgtcacattg aagcgccttg accgcgcttt 1114741 gagaatgcag atcttttttg aattcttcaa gatcgagact tgtattttca gcaatctcca 1114801 aaagcacgtt ttcatccgta atatttttct ttgaaacaaa taggctctcc tgcatatttc 1114861 tgagaaattg catgccggct tttcgtcctt gcagttcggc tgctttaaaa gcgagagcag 1114921 ccatataagg cgatgaaagc ggctgatcct gttcgaacca gacattgccg tcacatgaca 1114981 tgccagagcg gctcgcgatc ttttcccatg cttctgcgag aagatgcttt tttcgctttt 1115041 tatttaaagc ggtaaggctt gcggaagcga taatgcgtaa ggtgaaaaaa cgtccgtatc 1115101 tgattttcag ctttttgatg acgggctcta aggaccagca ttcaggacat aaagggtcta 1115161 caaacatata aatttcaagc ggtttttttg gatgaccgtg gcaatgggcg aagtatagct 1115221 catgctgata gtttgtcaag atgatcgatc ctccgcttcc gtttgattca ccatatgcct 1115281 tgctgtcaac tccagccggc caaacaaaaa ctcacgaatt tcgccctcca gccctacatg 1115341 gtccattgcg tccttcatac agctgagcca cgcatcagct ctctcgtttg taattggaaa 1115401 gggaagatgc cttgctctga gcataggatg gccgtgttcc tcagtataaa gaggaggccc 1115461 gcctaaatac tgagttaaga attgcttctg tttcctggcg gtttctgtca aatcgcttgg 1115521 aaaaatcggc ttcagcaaag gatgagacgc gacacgctca taaaaagtat caacaagttg 1115581 cgatagaagt tcctctccaa tcgcttcata aggtgcgtta aacgattgtc ccatgttgac 1115641 tactccttta aatatggcta ataggaatca taaatcctat tgcaaaaagt aattttctgt 1115701 atttcattgt ttcatctaga tttattttag caacaaggca tcatttctac aaacaaactg 1115761 ccttttatgc gtttgatgac tcatttcggc tgacagccgg ggtttgtatt tcatatcata 1115821 tcacataaaa atcaggaatg cgtaagattt cacttcgcaa aaaaaccaga gggaaagagc 1115881 acctctggtt acgcgtaata aactgaagtt atttttttta catagttttg cgtttcttgg 1115941 aaaggaggaa tgcctccgta tcggtcaaca ttccccggtc cggcgttgta agccgctaat 1116001 gccatagaca cattgccgtc gtatttatcc agcatttgtt ttaaatattt cgttccgccc 1116061 tccacatttt gctgcggatc aagcggattg gaaacgccaa gtgagcttgc tgttgacggc 1116121 atcagctgca tgaggcccat cgcacctgct ccgctgaccg cttttgcatt aaagcctgat 1116181 tcctgtttga tgacggcgcg gatcagtttt tcatcaacgc catatttatc agcggctttt 1116241 ttaatcgcac tgtcaataga gaagtctccc gaacggatct gatttgcttc atgtttgttt 1116301 gaagctgaat ctgcaacagc tgtttcagtg ctttctgccg cttttgtgac tgaacctgaa 1116361 ttgctgctcg tatatgagtt aagcccatac gctgaaagca gtgacggcgc tgttgtattc 1116421 gcgctgttca gcatgctgag cgggcttggc gatgaagaag gtgctgattg ctgagatgtc 1116481 agaccgtttg tatattggct gagcaaagaa ctgaaacttg aaagcgggct ttccgtattc 1116541 tgagtgtccg agctgctgcg tgcattagat atggactgta atgcctgaag ctgaagtaat 1116601 gctgcccaat tcgttacatt cacgatgtca ttccacctta tatagacttt cgtttttctt 1116661 cataaaaacg cagaatttta tttttggttt cgcgctgagg aatgctgaat tgctgaagca 1116721 gcttttcgaa ggcttgtctg ccctcatgcc aatccgccgc ctcaaattca atttcatagt 1116781 cctctttatt taaatatcgg ctgtggtcta aaactattaa gcctttttct gtttcttttt 1116841 ccgcacggtt tgttgctaaa gatccaaagt attgtatggc atccgtatcg atctgaagct 1116901 tgtgcagctg gtccttcaca gggccctcgg gaactgaaaa tccagcgaga tctgatacct 1116961 ctgaaagctg ctggtgcgtt tccagaagcc ccacatcagc cggctccttt aatgtaagga 1117021 catactttcc gttttttctg cggatacgaa gcgcagcatg tttttgtttc agcgcgaagc 1117081 tgtctgtatc aaaataatga ttcttttgat ctgtaaaatc tttttctgtc agctggagtg 1117141 ccgatgctat gtttttgaat tcttgtttgg tcagcatgtt tttaaattcg atttcaatct 1117201 cttggctcat gatgctcttc ctttccgccc tgtaaatctt atttttacta ttatctcttt 1117261 agatgttagg tttatcaata tcgagctcga tatgataaaa tgaatctgta ctttgtttaa 1117321 aaaaggagag cattatgcaa aacagaatcg aaattttgaa tgcaacatta tcggatgatc 1117381 agcttcgcct tgcctgtcag acagaaggaa acgaagcgga acgcaagccg tcaggtcaaa 1117441 tgcttgttga ttctgaccac tttgcttttg tatacatact tgaattagct gattcttttg 1117501 aatatgtcat tataaaggaa catgtatggc cggaactgaa gcaggcccat gcacaaaaaa 1117561 taccggttgt tttagaggca ggagaccaaa caattgaact ggcaggcctg catgaggagc 1117621 tggaatatct tttagaaaat ataaaagata atgcaaacta tggagaagaa atggaagaaa 1117681 aagtgaaacg cgtgttttta tagaaactgg ttcggaattg ggggatgtat gatggatgac 1117741 aaacaatggg agcgtttttt agtgccgtac cgccaggctg tcgaagagtt gaaagtgaag 1117801 ctcaagggga tccgcacact atatgaatac gaggacgacc attcaccgat cgaatttgtg 1117861 accggacgcg tcaagcctgt ggcgagcata cttgaaaaag cgagacggaa aagcataccg 1117921 ctgcatgaaa ttgaaaccat gcaggacatt gctggcctta gaatcatgtg ccaatttgtc 1117981 gatgacatcc aaatcgtaaa agagatgctt tttgccagaa aagatttcac cgttgtggat 1118041 cagagggatt atattgcgga acataaagag agcggatacc gatcatacca tcttgttgtg 1118101 ctgtaccctt tgcagacggt atccggagaa aagcatgttc tcgtagaaat acagatccgt 1118161 acactggcga tgaatttttg ggcgaccatt gaacattcat tgaattataa atacagcgga 1118221 aacattcctg aaaaagtaaa actaaggctt cagcgcgctt ctgaagcggc ttcccggctt 1118281 gatgaagaga tgtcggagat caggggtgaa gtacaggaag ctcaagctgc cttttcaaga 1118341 aagaaaaaag gaagcgagca acaataggta aaggggaaga agagcatgaa atttgccgta 1118401 tcatcaaaag gagatcaagt ttctgatacg ctgaaaagca aaatacaggc gtatttattg 1118461 gattttgata tggaactgga tgaaaatgaa ccggaaatcg ttatttcagt cggaggcgac 1118521 ggaacgcttt tgtatgcttt tcacagatac agcgaccgtt tggacaaaac agcatttgtc 1118581 ggcgttcaca caggtcatct gggtttttat gccgactggg ttcctcatga aattgaaaaa 1118641 cttgttcttg ccatcgcgaa aacgccgtat catacagtcg aatatccgct tctcgaagtc 1118701 attgtgacct atcacgaaaa cgagcgggaa gaaagatact tagctttgaa tgaatgtacg 1118761 attaaaagca tcgaaggaag ccttgttgct gatgtggaaa tcaaagggca gctctttgaa 1118821 accttccggg gcgacggcct ctgcctgtca actccatcag gcagcacagc ctacaataag 1118881 gcgctgggcg gagcgattat ccatccgtct atcagggcga tccagcttgc ggaaatggct 1118941 tcaattaata accgcgtgtt ccgtacggtc gggtcacctc tgcttctccc atcccatcat 1119001 gattgcatga ttaagccgag aaacgaagtt gactttcaag tgacgattga ccatttaacc 1119061 cttctccata aggatgtaaa gtcgatccgc tgccaagttg catccgaaaa agtgcggttt 1119121 gcgagattcc gtccgtttcc attttggaaa agagtccagg attcgtttat tggaaaaggt 1119181 gaatagaaag aggacatatc gtggagcatt tttttatcag aaagaacatt acttccgctg 1119241 aggacgggat gactgtaaaa gaatatgccg gtgaactggg aatttcgaaa cgtctgctga 1119301 ccgatattaa gtttggcggg ggagacctgc agattaacgg tgagcatgtg acggtcaaat 1119361 acgttttgaa agagggagat cttcttatcg tgaagtttcc tgaggagcag gtgagcgaga 1119421 cgctgttggc agagcctgtt ccgctcgata tcctttatga ggatgaacat gtgcttgtga 1119481 taaacaagca gccgtatgtg tcatcaatcc cttcgagaga gcacccctcc ggcagcattg 1119541 ccaatggaat tattgatcat tatcaaacaa ccggagtgag ggcgacagtt catcttgtca 1119601 cccggttaga ccgggataca tcaggtatca tgcttgttgc caagcatcga tttgcccact 1119661 ccattttatc gtctgcgcaa aaaaacggcc ttgtgaaacg ccggtatgcg gcagtggttc 1119721 acgggcggat ggcacagatg gagggaacag tcgatgctcc gattggcaga catcctgaca 1119781 gtattattga acggacggta acgccagacg gccagaaggc tgttactcat ttttacgtca 1119841 catgtgcaaa tgatgacatg acctcggtgg cattgcagct tgagactgga cgaacccatc 1119901 aaattcgtgt tcatatgagc tatctcgggc acccgttgtg cggcgataca ctgtacggcg 1119961 gaacgagaca ggaaattggc cggcaggctc tgcacagcga gcatctttcg tttatccatc 1120021 cgctgacaca ggagaacatg aggtttcatg ctccactgcc tcaggacatg agcaaactga 1120081 taaaaggaga gaatcattga ttctctcctt ttttatatgg ggcgaaatct tgattcgtcg 1120141 taaggcaggg agcttggaac agagacggtt tctatttctg gaaagcgaaa gcctgtcagt 1120201 tgatttccga acacgcagcc tgtatcaatg ttgatggtgc gattgacctt ccgaggctct 1120261 ttcacaggtg tatgaccgta taccacccaa gcctttccgt tataggctgc cgcccaatca 1120321 cgcctgatgg gtctgccgtc cggatatgtt tcacccgtca cgtcaccgta aagcacaaag 1120381 tccttcactc tgcgggtata tttgccgata tcgtcagctc ttatgccagc atgggcgaca 1120441 actaattctc cattatgtaa gatgtcgtaa agcggcgctg tttcgtacag cttcataaac 1120501 tgttcgctga ctgatttttt ctcatctttg gaaagttcct caagctctgc cgctgttgtt 1120561 tcgagaccat gcatcacttt taccggattt ccttttaagt aacgatataa tttattgcaa 1120621 tggtttcccg ggacataacg cacagcgcct ttttcgtaag cgccggctac aaatcggatg 1120681 acctctatcg atttgggccc tctgtcagtt aaatctccgg caaaaacaag caccctgcct 1120741 tcttcatgga caggtactcc atttttgatt gtatagccaa gcttttggat taatgcagtc 1120801 atttcgtcat agcagccatg aatatcgctg atgatatcgt aagccatgcg gtctcctcct 1120861 taccgattgt tttatttatt atgaagcaaa gtgttgtgag tcatcacaag cttttatgtg 1120921 caaattatag aagaagaatc attttctaaa caggattaag accttatcac tttatttttc 1120981 atcatcaccc ttgttaaaat cgcgttatgt tttttaaaaa tgaggttttg ttctctgagt 1121041 gagaactagc ataaccctga cttaaaaagg aggttctgat tatggcgcat acatctgtcg 1121101 catctttagt tgttgtactt atcgttgcat ttttgacacc catccttttg catcggttta 1121161 aactcagcat cccggttgtt gttgctgaaa tcattatggg gctgataatt gggaaaagcg 1121221 gccttaattt agttgtggag ggtgacacct ggctccagac actctctatg ctcggattta 1121281 tctttttaat gtttttaagc gggcttgaaa ttgatttttc gtcgtttgag aaaggaaaga 1121341 aaaagcagtt cctgccgaat ggcaaggaag cgccgaatac gtttgctgcg gcatctgtta 1121401 ttttcgtcgg tatttttatt ttatcattgc tcttgtccta tgggttcgtc ttggccggat 1121461 ttatccaaaa tgcatttttg atgaccctga ttatttcaac gatttcatta ggcgttgtcg 1121521 ttccaacatt aaaagaagaa cggatcatga attcgaatat cgggcagatt attttgcttg 1121581 ttgctgttat tgctgatttg gccacgatga ttcttcttgc tgttttttct tctttatacg 1121641 gagaggacag cggaaacatg tggctcctga tgattctgtt tgcggccgga gtggtgcttt 1121701 actttttcgg ccgggtcttc aaacatcgct cttttgttca atccatgtca aaagggacga 1121761 tccagatcgg gacgcgtgcc atttttacgt taatcattgt actcgttgcc ctgtctgaat 1121821 cacttggggc ggaaaatatt ctcggcgctt tcttagcggg ggttcttgtt tccctgcttt 1121881 cgccaaacaa agaacttgtt cagcagctgg actcattcgg ttatgggttc ttaataccga 1121941 ttttcttcgt gatggtcggt gtgaagcttg atatttggac tcttttccag gataaaacaa 1122001 ttttaatcat gattccgctc ctgctgcttg cgctgttagt cagcaaaatc attcctgtca 1122061 tgtacttaaa gaagtggtat gataaccgaa ccattttcgc gtctggtttc ctgctgacat 1122121 caacgctttc gctcgtgatt gctgctgcaa caatcggcca gcagcttcac gtgatcagta 1122181 caaatatgtc aggagcgcta attttagtag ccgtcattgc aagtattttt acgccgatct 1122241 gttttaaaaa attatacaaa cgggaagagc agccggagga gaaaaagacg attacgttca 1122301 ttggcgccaa tcaaatgact ttgcctgtca cactcgaatt gccagaggaa gagtatgacg 1122361 tgcgtgttgt acacgtctac caagagaatg cggaggaaaa gctgtcagaa tcagtgtttg 1122421 ctgttgaaac aatttctgac tatgaacacg agacgcttga atcactcggc atttttgaaa 1122481 cggatatcct cgttgtggcg acaggaaatg aagatatgaa tgcagacatt gcattacttg 1122541 caaaagataa aggcacagaa agagtcattg caagcgtagg atcaccggag catgaagcag 1122601 ctctgaagga gcagggaatc agcatctttt ctattctgct gtcgacaaaa acgctgcttc 1122661 gcgcactgat tgaagcgcct ggcgtcatga agctgctcac gaaccaagag tcttcgctgt 1122721 atcaaattaa tatggagaac agtaaatatg atggtgtcat tttacgggaa ttccctttaa 1122781 caggtgacgt catctttgtc aggatcttca gaggtgtgga cagcatcgtt cctcatgggg 1122841 atacgaggct gaaacttgga gaccgtttaa ttgtcaccgg atctcggggg tacgtaacgg 1122901 atcttaagaa aacattggaa ggataaatct tgaccaaata aggattcgtg ttaatataga 1122961 ggtgcagaac aattcaatat gtattcgttt aaccactagg ggtgtccttc ataagggctg 1123021 agataaaagt gtgactttta gaccctcata acttgaacag gttcagacct gcgtagggaa 1123081 gtggagcggt atttgtgtta ttttactatg ccaattccaa accacttttc cttgcgggaa 1123141 agtggttttt ttattttcag agggggaatg atttgtgaag ttttcagaag aatgccgcag 1123201 tgcagccgca gaatggtggg aggggagctt tgtccatccg ttcgttcaag gaatcggtga 1123261 cggaacgctt ccgattgacc gttttaaata ctacgtactt caggattcct attatttaac 1123321 gcattttgca aaggtgcagt catttggtgc cgcttatgcg aaggatcttt atacaacggg 1123381 gcggatggca agccatgccc aaggtacata tgaggcggaa atggcgcttc atcgcgagtt 1123441 tgccgagctg ttggaaatca gcgaggaaga gcgtaaggcg tttaagccgt ctcctacggc 1123501 gtactcttat acatcccata tgtaccgttc ggttttgagc gggaatttcg cagaaatctt 1123561 agcggccctg ctgccatgct attggctcta ttacgaggtt ggtgagaaat tgctgcattg 1123621 tgatccgggg catccaattt atcagaagtg gattggcaca tatggcggtg attggtttag 1123681 acaacaggtc gaggagcaaa tcaaccgctt tgatgagctg gcggaaaaca gcacggagga 1123741 agtgcgtgcc aagatgaaag agaattttgt catctccagc tactatgaat atcaattttg 1123801 gggaatggcc tatcgaaaag aaggctggtc tgacagcgcc ataaaagagg tggaggaatg 1123861 tggagcttca cgccataacg gatgacagca agccggtaga agagctagcg agaatcatca 1123921 ttacgattca gaatgaagtt gattttattc acattcggga acgctcaaaa tcggcggcgg 1123981 atattttgaa actgctcgat cttatttttg aaggcggtat agataaacga aaattggtga 1124041 tgaacgggcg cgtggatatt gcacttttct ctactattca ccgcgtgcag ctgccaagcg 1124101 gcagcttttc accgaagcag atcagagcca gatttccaca ccttcatatc gggaggtcgg 1124161 tgcattcact ggaggaagcg gttcaagcag aaaaggaaga cgcggactac gtgctgttcg 1124221 gccatgtgtt tgaaacggat tgcaaaaagg gtcttgaagg cagaggagta tctttgctgt 1124281 cagatatcaa acagcggatt tccatcccgg ttatagccat cggggggatg acgccggaca 1124341 ggttaagaga cgtaaaacaa gcaggggcag acggcattgc tgttatgtca ggaattttct 1124401 cttccgctga acctttggaa gcagccagac gatattcccg caagctaaag gagatgcgct 1124461 atgaaaaggc attatgaagc agtggtgatt ggaggcggaa ttatcggttc cgcaattgct 1124521 tattatttgg caaaggaaaa caaaaacacc gcattgtttg aaagcggaac aatgggcggc 1124581 agaacgacaa gtgccgctgc cggaatgctg ggcgcccatg ccgaatgcga ggaacgtgac 1124641 gcgttttttg atttcgctat gcacagtcag cgtctgtaca aaggtcttgg agaagagctt 1124701 tatgcattat ccggtgtgga tatcaggcag cataacggcg gtatgtttaa gcttgcattt 1124761 tctgaagaag atgtgctgca gctgagacag atggacgatt tggactctgt cagctggtat 1124821 tcaaaagaag aggtgttaga aaaagagccg tatgcgtctg gtgacatctt tggtgcatct 1124881 tttattcagg atgatgtgca tgtggagcct tattttgttt gcaaggcata tgtgaaagca 1124941 gcaaaaatgc ttggggcgga gatttttgag catacgcccg tcctgcatgt cgaacgtgac 1125001 ggtgaagccc tgttcatcaa gacccctagc ggagacgtat gggctaatca tgttgtcgtt 1125061 gccagcgggg tgtggagcgg aatgtttttt aaacagcttg gactgaacaa tgcttttctc 1125121 cctgtaaaag gggagtgcct gtccgtttgg aatgatgata tcccgctgac aaaaacgctt 1125181 taccatgatc actgctatat cgtaccgaga aaaagcggaa gactggttgt cggcgcgaca 1125241 atgaagccgg gggactggag tgaaacaccg gatcttggcg gattggaatc tgttatgaaa 1125301 aaagcaaaaa cgatgctgcc ggctatacag aatatgaagg tggatcgttt ttgggcggga 1125361 ctccgtccgg gaacaaagga tggaaaaccg tacatcggca gacatcctga ggacagccgt 1125421 attttatttg cggctggcca tttcagaaac gggatcctgc ttgctcccgc aacgggcgct 1125481 ttgatcagtg atctcatcat gaataaagag gtcaaccaag actggctgca cgcattccga 1125541 attgatcgca aggaggcggt tcagatatga tgctacagct gaacggtaaa gacgtgaagt 1125601 ggaaaaaaga cacaggtaca attcaagacc tgctggcgtc gtatcagctt gaaaataaaa 1125661 tcgttatcgt ggaaagaaat aaagaaataa tcgggaaaga acgctatcac gaggttgagc 1125721 tttgtgatcg tgatgtcatt gaaattgtcc attttgtagg aggcggatga gcatgttaac 1125781 aattggcgga aaatcatttc aatcaagatt gctgctgggc acggggaaat acccatcgtt 1125841 tgacattcaa aaggaagcag tagctgtttc tgagtctgat attttaacat ttgctgtaag 1125901 gagaatgaac atttttgaag catctcagcc gaattttctg gaacagcttg atttatccaa 1125961 atatacgctt ttgccgaata cagcgggcgc cagtactgct gaagaagcgg ttcggattgc 1126021 aaggctggcg aaagcttcag gcctttgtga catgattaaa gttgaagtca tcggatgcag 1126081 ccgttccttg ctgcctgacc ctgttgagac attaaaagcg tctgaacagc ttcttgaaga 1126141 aggctttatt gtgctcccgt acacgtcgga tgacgttgtg ctggcgagaa agctggaaga 1126201 gctcggcgtt catgccatca tgccgggtgc atctccgatt ggatcaggac aaggaatctt 1126261 aaatcctttg aatctgtcgt ttattattga acaggcgaaa gtaccggtca tcgtggatgc 1126321 gggaatcggc tcgcctaaag atgcggcata cgcaatggag cttggagcgg atggcgtact 1126381 gctcaatacg gctgtatctg gcgctgacga tcccgtgaaa atggctcgtg ccatgaagct 1126441 cgcagtggaa gcagggcgcc tttcttatga ggcgggccga atcccgctta agcaatacgg 1126501 aacggcaagc agtccgggag aaggtcttcc tgtatgacag gcaggtattc aaggcaggag 1126561 ctgtttgctc cgatcggccc atccggccag aaaaaattga aagaagcgcg cgccgtgatt 1126621 atcggcgccg gcgcgctcgg aacagccagt gcagaaatgc tggtgagagc gggagtcggc 1126681 tctgtgaaaa ttgccgacag agattatgtt gaatggagca acctccagcg ccagcagctt 1126741 tatacagaag atgatgtcaa aaaagaaatg ccgaaagcag ccgctgcgga gcgccgtctc 1126801 cgttcgatta acagcgatgt tgatgtgacc ggccttgtca tggatgtgac agcagaaaat 1126861 atcttcgagc tgattaggga tgcatcgatt attgtggatg cggctgataa ttttgaaacc 1126921 cgcctgatcg taaatgatgc tgcggtaaag gaagggattc cttttcttta cggtgcctgt 1126981 gtagggagct acggtcttac ctttaccgtg gtgccgggtt ctactccttg cctgcattgc 1127041 ttgctcgatg cacttccgat tggcggagca acatgtgaca cagctggcat catcagtccg 1127101 gctgttttgc aggtagcagt ctttcaggta acagatgcac tgaaactgct gacgggagag 1127161 gagtgcgagc cggtgctgcg ctcctttgat ttgtggaaaa acgagcggtc agaagtgaga 1127221 gcggccagtc tcaaacatga cgcatgccca agctgcggca caaaggattt tccgtttttg 1127281 tcttatgaaa atcaaacaaa agcggctgta ttgtgcggca ggaacacggt gcagatcaga 1127341 tcatctatta cgaaagaagc ggatcttgaa gcgcttgccg gtcagctgag gcaggccggg 1127401 cttgaagtag ctgcgaaccc gtatttaatt tcctgccgct cggatgatat gaaaatggtg 1127461 ctgttccggg acggcagagc tttgatccat ggaacaaatg atattgcccg ggcaaaatcc 1127521 atttatcata aatggattgg gtaataaaag gagtgtagtg taatgagtat atataaagca 1127581 ttgacaatcg ccggatcaga ttcaggcggc ggcgcaggga tacaggctga tattaaaacc 1127641 tttcaagagc ttgatgtatt cggaatgtct gcgattacgg cggtaaccgc tcaaaatacg 1127701 cttggcgttc acggggtgca tccgctgact gtagagacgt tgagacagca aattgacgct 1127761 gttgctgagg atttgagacc ggatgcagtt aagacgggaa tgctctggaa tgccgacatg 1127821 attgaagaag tggcaagaaa aattgacgag tacggattca atcgtgtaat tgttgatccg 1127881 gttatgatcg caaagggcgg ggcatccttg ctgcgtgatg agtcagttgc caccttaaag 1127941 gagttgctca ttccaagaag ctacgcgatt acgccgaatg tcccggaagc agaaacgctg 1128001 acaggaatga caatcagctc gctggatgac cggaaaaaag cagcggagca gctcgtcaag 1128061 atgggtgcgc agcatgtcat tatcaaaggc gggcaccagc ctgaggacaa tcacattact 1128121 gaccttcttt ttgatggcag catgtttatg caaatcaccc atccttatat caatacgaag 1128181 catacgcatg gcacaggctg cacctttgct gcggctttaa cggcccaaac ggctaaagga 1128241 gacagcatcc atcaggcatt tgaggttgcg gccaactttg tccgtgaagc ggtggaaaat 1128301 acgctcggca tcggatcggg acacgggccg acaaaccatt tcgcttttaa acgaaacagc 1128361 ttaaatacaa gccgatgaga tcaccagctg atggtgatct cttttgcgtt tgctacggta 1128421 tgcgcttttc atctggacaa ggttatgata tgataggaat taagatcagg tactaatact 1128481 atgtctttat taaatatagg aggctttata catatgaatt tttcacttga aggccgtaac 1128541 attgttgtga tgggggtagc caacaaacgc agcatcgcct ggggcattgc gcgttcttta 1128601 catgaagcgg gtgcacgttt gattttcaca tacgctggtg aacgcctgga gaaatccgtt 1128661 cacgagcttg ccggaacatt agaccgcaac gattccatca tcctcccttg cgatgttaca 1128721 aacgacgcag aaatcgaaac ttgcttcgca agcattaagg agcaggtcgg tgtaatccac 1128781 ggtatcgcgc attgtatcgc gtttgccaac aaagaagagc ttgtcggcga gtacttaaac 1128841 acaaatcgtg acggcttcct tttggctcat aacatcagct catattctct gactgctgtt 1128901 gtcaaagcgg cacgtccgat gatgactgaa ggcggaagca ttgtcacttt gacgtacctt 1128961 ggcggagagc ttgtgatgcc aaactacaac gtcatgggtg tagcaaaagc ttctcttgat 1129021 gcaagtgtga aatatttagc tgctgactta ggaaaagaaa atatccgcgt caacagcatt 1129081 tctgccggcc cgatcagaac attatctgct aaaggcatca gcgatttcaa ctctatctta 1129141 aaagacatcg aagagcgtgc accgcttcgc cgcacgacaa cacctgaaga agtgggcgat 1129201 acagctgcgt tcttgttcag cgatatgtcc cgcgggatta caggtgaaaa tcttcacgtt 1129261 gattctggtt tccatatcac tgcccgctaa gcaggctgtt aatgatgcaa gggctgtctt 1129321 gctttctgta gcaggggata caaaaatctt gagcggttgg ctgttttgcc gcgcctgtta 1129381 gcagggcaag acaaatataa atgctgtttc gcccgggtca tggctacata taaaaggcgt 1129441 ctttcctcct caagagcggc ctcgtctcct tttcttgccg tttctaatga gaaatcgtgc 1129501 ggaatcgagc catctacagt gcctaacacg tagactgttt tgaattcaag gccttttgac 1129561 cggtgaatgg tcatcagctg aacgccatgt tcatccgttc tgtttttctc agcggccctc 1129621 atatggtcta cgtgggcaag aaagtcagga atcgttttga acttcttggc gacaaccttg 1129681 atgtcgcgca ggtcatcaga gcctttttcc agcttgttgc cctcattgcc ccgctttttt 1129741 aaatactcgg agaagcccat ttttccttct gcaaaggtga tggcttctac gggtttcatt 1129801 gtgcggaggc ttgcaaaaaa cggtacgatt ttcttgattt tgtccagctg gaatggcttc 1129861 agatcaggca atttggccag cgctttgatc atggtacagt cctctgtaat cgagagcgcc 1129921 ttcagcgtat tcaaagcgga ctgttttaaa aacaaggcgg gaagcaagtg tttaatcgcc 1129981 tcggtgtcat cctcattttg gctggcgtac aagtaggcga gaatctggcg gacgatccgt 1130041 ctgctgtaaa acgattggac gccgcggtca gctgtatacg gaattgacga ttgatgaagc 1130101 ctttcatata tagcacggcc tccgctgttt gtgcggtaaa gaaccgcaaa gtcttctgga 1130161 ctggctccat tttgaatttt ttctttgata tcggaaacga ccattgtggc ttcttcctct 1130221 tcatcataag gataaaacag cacagggacc tgaatgtcat cgcgggccgc ttcaagcgtt 1130281 ttggcatatc tgtttttgtt ctttttcaca acgatatcag cactagagac gatcgggtgc 1130341 gtagacctgt agttcgcagt taaatagatc gtcttcgctc ccggataatc cttttgaaaa 1130401 tcaagaatga aagacggatt gcttccgcga aacgcgtaga tggactggtc atcgtctccg 1130461 acacagcaca ggttttgctc cgggctggcg agcatttgca tgattttgta ttgaaccgga 1130521 ttaatgtcct gaaactcatc aattaagata tacgtaaacc gagattgata ttgttccaga 1130581 aggtcaggcc gctcgataaa caattcatag caggctgaag ccatgtcatc aaaatcaaat 1130641 tggctgtgtt cttttttctg gcgttcataa tgttcatata aacgataaac ttgtttttcc 1130701 cactcatctt ttagagggat gcgttcattt gggacataag tgtttttcca aaaaccgatc 1130761 tgctgcaggg cttggtcaac tggggattct ttctcatcga tgccttcttc atagagtgct 1130821 tttttgatat attgttcccg ctgccactcc attttcagca gatgctcacc gttccattta 1130881 gcagaattag agtgatacaa gatcttataa aacagactgt ggaatgttcc tgtcacaatt 1130941 cttctgactt ttgccggctg taatccgtac tggttcgcca tacgctcttt catttcagcg 1131001 acagcttttg ttgtaaaggt gacaagcagc atattttcag gcggtatgcc taagtgttcg 1131061 atcatgtggg cggcacgggc tgtcagtacc cgtgtttttc cgctccccgc acctgcaagc 1131121 acgaggagcg ggccctctgt ttccgtgaca gctttcagct gatccgtgtt taaaccgaca 1131181 gacggaaaaa ggctcgtatc gggttctatt gtttttggca caaatggtgt tcctggttta 1131241 atgcttctag gacggtgcca ttctgtaaca gctggggacg ggtcagcggc gatcgctttt 1131301 cccttgggta aacgaatgac accagattcc tgatcatctt cttttttccc ctctttagag 1131361 ggcttcggtt cgcacgcctc ctcacatgcc ggaaaatcgc ctggctggcg atggataaac 1131421 tctggcggat cggcgatgtt aagccgtaac aaaacgggct ttccgcaatg agaacaaaat 1131481 aaatgtcctt ttattccctc ttcaaagagg aattgataat gttctctcga atatgtatgt 1131541 aaatgtatga ttctatcatt cagtcgggcg catttcaaaa aggggtcctc ccaatcaaaa 1131601 ggtgttcatt acagacaatg actatcatat caaaagaaat gtgtttcaaa aagtaagttt 1131661 aagggaaaag agacagcaga ggggtgggta ttgtatgata tatgcaggtc aaattcagaa 1131721 ccagcaatac gctcaatatg ctaatagaac gattggacat aagcaggatt atgccggaac 1131781 cgaaaaaatc agctatgtcc cgtttcagcg ggtatacaaa gaactggaaa agcagcagga 1131841 gaatcaaacg gcagctgaaa gaaaagtaaa cgagatgaaa cgtaagcgct ctctttataa 1131901 gagattgcga gaaaaaggaa tggggacata tattaatcga tatgtataaa aaaccgttca 1131961 taccagagaa cggttttttt atatgcagta aaaatccgga tctcaaaaga tccggatgcg 1132021 ttcagtcctt catcatttgt aagtgcggaa tgccggcatc gaggaattct ttttcagaaa 1132081 gcacgcgata cccgtgtttc ttgtaaaacg gcacagcctg tgtttgcgcg tttaaaatga 1132141 aaccggaagc gcctccgtct gccgcggctt tttcgagcgc tttcataatg atgccgccga 1132201 caccggctga gcggtggctt ttcagtacgc aaatccgctc taacttgccg tagccgtcct 1132261 tcatgcgcca tcttccggca ccgacaggct tttcaccgtc atacacgacg atatgctctg 1132321 actcattttc aagttcgtca atttcttctt cagcaggcac gttttgttct ttgacaaaga 1132381 cttcttctct tacatagaat gcatctttca gttgttcttc attttttgcg ataactgctt 1132441 tcaaacatta ttctcctctg cctagcaaga aggtttcata tactgtccac gatccgtttt 1132501 ccaactggta gagcaagtgg aaacggtcaa cgatttcttc atgcgacact tcctgcattt 1132561 ttaattgtcc cagcacatct gaatgctcat cgtcggaaag attttggccg accgtcacat 1132621 gcggaacgaa attatattcc tgttctcctg ccaacacacc ggtgtatagc ttttcattga 1132681 gtgtttttaa ctcttccgtc ggttctgctt tgatgtaaat gacattattg acaggcgcaa 1132741 atgagctgta ttttgtcatt ttgagaacga gtgggtggga ctcttttgcg atgtttctta 1132801 aatgtgatac gagctgatcc gctttctcct ccgcgcattc aaaggatgct ctcagcgtca 1132861 aatgaggcgg gattagagag tagcttgggt catagcgctt tctgtaagag tttgcaaggt 1132921 cttggagctt ttttgatgga aataaaacga ttccgtattt catattatgt ccctcctgga 1132981 aataaagtat gatagagtgt taaagcattt ttttcagcgc cggggtgatg agcggctgcc 1133041 agtatgtcca tttgtggtct ccgtcaaatg gctcgaaatc ataatcggaa agctttttct 1133101 ccagcagctg tttcagctcc cggttcggtt ctgtaaagtc cagaatgttc ccgtctgtcg 1133161 tgtggacgtc agtttctttt gttccgattt ggtgataaat agagaggtgt ttgatatcgt 1133221 ctgactgttt tacggcttct agtacgtgtt tgtcaacata gggagactgc atgatgatgt 1133281 tgccaaacat attcggataa tcaagcgctg tcataagtga cacggttgct ccgagcgaat 1133341 caccgatcag cgttcggccg taaccgatct gataggttgg atactcatca tctgcaaaag 1133401 gaacgagctc atgggcgatg aaccgtttat aagccgaaaa ttttgaaccc tccggatgat 1133461 aagtgtttct gcgctctttt acatccttat agggaacacc gataataatg ctccggtcta 1133521 tttcgcgttt cgacagcaat tcctcaacct gtctgccgat tctccccagc ctgaaataat 1133581 cgtggccgtc ctgcgcgata atgacatggt atttataaag cggggagtag ttggacggca 1133641 gataaacaag caaggtcatt tcctcgttaa gctcttttga aaagaatttc ttttcttgca 1133701 ctgtgccgtt tttcggtgcc ataaaaacat tcctccagga catcactata ctttcttgca 1133761 ttttcaatta ttgtaccatg aattattaga aatttctctc tttaaacggt tcggcacacg 1133821 aagaaaaaag tgttgaaata aactgtgaat tgcgctaata taaaacaatc agaaaattga 1133881 aatcgatatt tcttatcgtg agaggtggag ggactggccc ttagaaacct cagcaaccgg 1133941 cttgttttgc atttgcaaag cgccaaggtg ctaaatccag caagcgtttt ttatgcttgg 1134001 aagataagaa gaagcgttaa accccttctt cttatgaaga aggggttttt attttgaaaa 1134061 gggaaggtgt cagctatatg tcacagcacg ttgaaacgaa attagctcaa attgggaacc 1134121 gtagcgatga agtcacggga acagtgagtg ctcctatcta tttatcaaca gcataccgcc 1134181 acagagggat cggagaatct accggatttg attatgtccg cacaaaaaat ccgacacgcc 1134241 agcttgttga ggacgcgatc gctaacttag aaaacggcgc gagagggctt gcctttagtt 1134301 cgggaatggc tgctatccaa acgattatgg cgctgtttaa aagcggagat gaactgatcg 1134361 tttcatcgga cctatatggc ggcacgtacc gtttatttga aaatgaatgg aaaaaatacg 1134421 gattgacttt tcattatgat gatttcagcg atgaggactg tttacgctct aagattacgc 1134481 cgaatacaaa agcggtgttt gtggaaacgc cgacaaaccc cctcatgcag gaggcggaca 1134541 ttgaacatat tgcccggatt acaaaggagc acggtcttct gctgatcgta gataatacat 1134601 tttatacacc ggtcttgcag cggccgcttg agctgggagc tgacattgtc attcacagcg 1134661 caaccaagta tttaggcggg cataacgatc tgcttgctgg acttgtcgtg gtgaaggatg 1134721 agcggctcgg agaggaaatg tttcagcatc aaaatgcaat cggcgccgtc ctgccgccat 1134781 ttgattcgtg gcttctgatg agaggaatga agacgctgag cctcagaatg cgccagcatc 1134841 aggcaaacgc gcaggagctt gcggcgtttt tagaagagca ggaagaaatt tcggatgtgc 1134901 tgtatcccgg aaaaggcggc atgctgtcct tccgtctgca aaaagaagaa tgggtcaatc 1134961 cgtttttaaa agcactgaag accatttgtt ttgcagaaag cctcggcggg gtggaaagct 1135021 ttattacata ccctgcgacc cagacgcaca tggatattcc tgaagagatc cgcatcgcaa 1135081 acggggtgtg caatcggttg ctgcgctttt ctgtcggtat tgaacatgcg gaagatttaa 1135141 aagaggatct aaaacaggca ttatgtcagg tcaaagaggg agctgtttca tttgagtaaa 1135201 cacaattgga cgctggaaac ccagctcgtg cacaatccat ttaaaacaga cggcggaacc 1135261 ggggcagtca gtgtaccgat tcagcacgcc tcgacttttc accaatcttc atttgaagag 1135321 ttcggggcat atgattacag ccgctctggc acgccgacaa gaacagctct cgaagaaaca 1135381 attgccgcac tggaaggcgg aacaagagga tttgctttca gttcaggcat ggctgccatc 1135441 tcaacagcat ttttactgct gtcacagggt gatcacgttc ttgtgacaga agatgtatac 1135501 ggcggaacct tccgtatggt gacagaggtg ctgacccggt ttggcattga gcatacgttt 1135561 gtcgacatga cggatcgtaa tgaagtggcg cggagcatca agccgaacac aaaggtcatt 1135621 tatatggaga cgccatcaaa tccgacactt gggattacgg atattaaagc agttgttcag 1135681 cttgcaaaag aaaacggctg cctgaccttt ctggacaata cattcatgac gccggcactg 1135741 cagcgtccgc ttgatctcgg cgtggatatt gtacttcaca gcgcgacaaa attcttaagc 1135801 ggacacagcg atgtgctctc aggtttggct gctgtcaaag atgaagagct tgggaagcag 1135861 ctgtataagc tacaaaacgc gttcggcgcc gtccttggcg tgcaagattg ctggcttgtc 1135921 ctgcgcggat taaaaacatt gcaggtccgt ttagagaaag cgagtcaaac agctcagcgg 1135981 cttgcggaat ttttccagaa gcacccggcg gtcaagcgcg tgtattatcc gggactggct 1136041 gatcatcccg gcgctgaaac ccataaaagc cagtcaacgg gagcgggcgc cgtgctatct 1136101 tttgagcttg aaagcaaaga ggccgttaag aagttagtcg agaatgtgtc actcccagtc 1136161 ttcgctgtca gccttggcgc cgtggaatcg attttgtcct atccggcaac gatgtctcat 1136221 gcggcaatgc ctaaggaaga gcgtgaaaaa cgcggtatca ctgatggcct gctccgtctg 1136281 agtgtcggcg tcgaacatgc agacgattta gaacacgatt tcgaacaagc gctgaaagaa 1136341 attgctccag tttcggttcg ttaaaaaaga agccggggat agtccggctt cttttattat 1136401 tgttcgtcat caggattcag aatcgcgagg acttgatgat cctcccaaac gccattaatt 1136461 tttacatttt ttcgggcgat gccttcttta tgaaatcccg ctttttctaa aacacgcatg 1136521 gacccgagat tacggggcat cacaccggct tcaatccgat gcagtttcaa ttcgtggaac 1136581 gcataatcaa caaccaatct gactgcctct gtcataatgc cctttccatt atgggctttg 1136641 tctaaaaaat acccgatgaa cgcagtttgc agcgcgccac ggatgatttg aaagagcgaa 1136701 accgtcccga ttaatctatc gtctgacgct gtaaagatgc caaaatgata ttcttcatct 1136761 ttctcaagtc tttcctgata ctcggttatt cgttttcttt gcccctcaac cgtatagtaa 1136821 tcgtctgcgc gtatcataga aaactgttcg aaaaaatctc gattttcgct ttgcagcccc 1136881 agattttctt cggcatccgt tacttctaaa ggtctaacat aaatggtttt tccttttaac 1136941 atatagtgat ctctccgttc tcatgtcagc attcctctta cattattctc agggaaatgc 1137001 aaatatcctt tttataagaa ggaagaaaac caatttccca taaaagtgcc aacatagttg 1137061 ccgattaagt agccgagcgt accgacaagc atgatcgggg cgacaagctc ccgccatccc 1137121 ttggcaattg ccatcgcagc cgcagtcgtc ggtcccccga cagtagcgtt gacggcgagc 1137181 agaatttctt caagccgcac acggaacaat tttccggcag ctaaggaaac cgctaaattg 1137241 ctaatcgcaa tgataaacac gaataataga ataagaggcg cattcgtgac gattaagcgg 1137301 agatctgcag gaatgccgat caccacaaaa aacaaataaa tcaaaaaggt tccaagctcc 1137361 tgagatccat tgagcctttc aaaaaaacgc gggaaaagaa aaatgataag aacagttaaa 1137421 gacgtaagaa ccaggtactg atcgccaagc gtaccggtca gcaggggatg agaaaaaatg 1137481 cttttaaaat aaccggaaac cttcatacta accgcaacaa gcgcgaaagc ggcaccggca 1137541 ttaaaagcga tatcctttaa ggaaatatcc ttccgtttcc aatagctttc agcactgttt 1137601 ccgctgtttc catcggcttt taccttctct tcaaacggca tggcataatg ccgctgaaac 1137661 catttgagtg caggaatgct gattaaaata aaaaacaaaa gcgccatcat aaaattatca 1137721 gccacaacgg tagccgacac atattcacca ggcgtctcaa attttgccgc catcgccgca 1137781 aagttgaccc cgccgccgat ataagaggcg ctgatcatcc caccgatttt atctaagtaa 1137841 ggaatatgct gtttgagtag aaaaaaagcc aggatactgc caagcactgt tccaacggag 1137901 ctaatcagaa aaataaacag caaacgcctg ctttccttaa aaatttgcct aacattgatc 1137961 tgaaacaata aaagtggtat cgccagcggt accacataag accacacagt gtcatacacg 1138021 ggcgactcaa caggaagcac tcctacattt gtaaacacca tagcacctgc aagggcgata 1138081 atagcgcccg acacagcaga cgcccactta aagcgctgct ccagcccgat gctcactgcc 1138141 gcccacaccg caataaaccc ccataatacc catacatcat cagaagaaat caaagaatgc 1138201 aaaaccccat cacctctatt gttagaaaat taagacatat tataatagcc ggggaacgga 1138261 acagcaagtc caaaaaaagt ttttctaaaa aagcagttga cgaatagaag gtaaggttat 1138321 ataatagaac ttgtcagaaa gataacaaca tacccagcaa cacatacata tcatgattcc 1138381 gtagctcagc tgggagagcg ctaccttgac agggtagagg tcgctggttc gagcccagtc 1138441 ggaatcatag cttaaaccct tgcgcagcaa gggtttttta ctttgcgtta ataaagccgg 1138501 ttcgtcaaat tcgtgagttg ttggcgaact gttggcgaaa ttcattgacc gcagtccaaa 1138561 aactacctcc aaacttactt gattagttca atagtaacaa acggaagatc ggatttctgt 1138621 taaatcttca ttgagaatag ccagtccaag accgtcactt cagccatgca tcttttaaat 1138681 gaaattttgt actgaaaaca tcaattgtat ttttaaattc tgctctagaa tcagcccctt 1138741 tataataatc ttgataaatt gcttggggtg atactgattc gtgatttgtg ctatggtttg 1138801 caaggcttgt agcaaaagca ggagcaacag taacgagtaa agcaagggat aatgcaaaac 1138861 cagttaaagc tttttcaatt tcattttaag cacttctttt tttaaaatac aactttatta 1138921 ttaaatggaa tacaaaaaca tccaaggtgt ttttttgtta gtaagttgag ttagggggat 1138981 tggatggcac ttagaatatt gtttctgctg atgggatgtt gattctggat atatttccaa 1139041 cacgattaca ggccggacat gaaagcgaac cttgctttga tcggggcaat catttcattt 1139101 acggctgcgg tttactttaa agatattgat gtattgagag aagagggaaa acaaatgaac 1139161 ggaatttctg agcgttggaa cacgtttaaa ttacaaaaat cccctgaacc actctagatc 1139221 aggggattgc tttcccaaca gcttattaag tagcggaagg catgatcaac gatttagtat 1139281 caatttatta attgcgaata ctagaaacat accgttttcc gccttcctta gaagtaacat 1139341 attctcgagg aacattaagt ctattggtag aatgataact tacataaagt ttcatatttg 1139401 ctcggctcgt tacgatagcc gtatgatcca tccaaccatc agcatagcga agacctattt 1139461 tattatggta atcatagtga tatacatctc caagctttac atttgaatat gtatcagaaa 1139521 cagtcttcat ttttattccg ccagctttta aaatgtatga tctaaaggct cctgcattaa 1139581 cccaagcatc tgtatagggt ttccattctt taaagtacgg cattcttcca gctcttaatg 1139641 cttgggaaac aaagttagta caatctttgt ctttataata tttatagttt ttatttggtt 1139701 ttaaggcata tttttctgca tatttcattg cagcgtaacc actatatcct ttaacagatg 1139761 ttgcagtcac agttagttga ttagagttag cagcattgaa gttcatactt actggtttat 1139821 cttcactttt cacttcttct ttatcatcat ttttcacttc ttgcttatat ttttttaaaa 1139881 attcatctaa tttaacatcc gaagaatatt cttcatcatt ttcatattgt agagttgaag 1139941 aagaattatt taattgtgtt acatttagtt gcttagaaga attactcaat ggtattacat 1140001 ttagttgatt agaagaattt ttaacttgag agaaacttag attagaagta tttgttgatt 1140061 gagaactttg tttattagaa gttgttttgg gaatttcaag tttaatatta tcgcccagag 1140121 atgttgttac tttttcaaca ccaaaaacaa agtttcgagt aatataagct tcaacaatta 1140181 gcttattgtt tttttcagaa gtcttaacat cgtctatatc gtatgtaaac tcgtggaatt 1140241 tttgtttgtc cactttactt aacgcagaat acagtaagac tccttcgtcg gaatcagtca 1140301 atttagactc tttaggatgc gctaaaggag tgttgtgttc aaaatcatat ttttgttgtt 1140361 ctaacatatc cttaactttt tcgtaaccaa tctcgttggt aattgaaaca ttttctttag 1140421 tctctttatt agtagtggct gcaaaaactt catttgttga cactaatggt gacaatgata 1140481 gacataaaac tagtgaagca agtaattctt ttttcatacg aaacctccaa taaaatctaa 1140541 atataagtaa tatttatcat ttacaccaat tgaaatatgg cataaaatac atgtaataat 1140601 ataacataaa aataaataca taaaaaggta tcggaggaaa aaatgaaaaa gaaaactaaa 1140661 attatacttt ctctcttggc agcacttatt gttatattga tagtacttcc agttctatct 1140721 cctgttgtct ttacagcttc ttcggaaaaa ggagcaatca gacacgaaat ttataaaaga 1140781 ggatatccct accaaagcta ctttgcagtt ctccagaaaa gagaaggaga caatgaatct 1140841 gggaatcttt attatgtaaa ttggctagat tggaaagatg aaacagggca aactcctcac 1140901 ttatgctatt cgaaaaaatc atcagatggt gaatacgaag taagttgtgg cacagggccg 1140961 taaaaataaa ttttaaaatt gaataagtcc aagacggaaa gcctgcggac actgatcgtt 1141021 ttacagagaa atttgtgctt cgatcggtgt ccgttttttt tcgcaactaa ccagatgtct 1141081 atcgcgatta ctagctatga aaggagtaat tagacatgaa acagtccaaa aagaaaccat 1141141 cacagaagca acatgagcgc ttagatcgtt tctggcaaca aatgatgaac actaacatgc 1141201 aaacactcag acgtggcaaa ggcggcgctt ataaacgcag aaagtaaaaa gggagtttga 1141261 ggatgatgaa aaacggattc gcttataaaa acggaaagct tgtgaatatc ttttgcggca 1141321 aagaagagct ctataacgag ttgaaagcct tcttggtcaa aaccttcagt atcaacgtga 1141381 aagaggtatc gaggccctca atatatcgca gaacaaaaag caaacaactg gaatgacact 1141441 tactctattt aactatcagg agggaaagca ctatgacaga tcaaatgatt gcatgggaga 1141501 ttgaggaatg gattcgtgat tataaattca tgctgcggga gatcaaaagg ctcaaccgtg 1141561 tattaaacaa agtggatttt attagcacaa agctcactgc aacatacggg gaggaagcgg 1141621 gcatgccaag gggatcagca ggcgtcagtc aggcagaatt gcggcagatg gaccgaagag 1141681 aaaggcggct tcacaaatat gaatctattg tgcattacct ggacaatgca atggaacaca 1141741 ttgaagaaga aaagcaccga atcgtttacg attgcatgat ggaaggcatg agctacactg 1141801 ctattgcaaa ccaccttgat tgctcccggg ataccatcag aaagatcaaa acagccataa 1141861 tcggcaacat cgtcaataaa gtcaaagaag ccaactttct gcaatatttg aattcgttta 1141921 aatcggcggt gtaaaatggg gggcaggatc ggcgcggcgg attattcctg cgtcaccacc 1141981 aatttcatac aatgagtaaa acctcccagt ggtaagcgag gatcaactca actgggaggt 1142041 cttacatagt gaatcggtga taaaacagca gcagtattgc gtacatgtta atatccccga 1142101 caaaatatgt ttttttcaac agattcgttc gacaaatttt gcaaattgtt aatcgataac 1142161 ttttcattcc cgatattaaa aatgggagtg aattgtaaaa tgaaaaaaca gaaaaataat 1142221 aaaaagaaga atattgaaaa gcgaaatatt gaaaagcgaa atattgaaga gaagaataat 1142281 gaggacttag aagaactgga aaatgcgatt tatacttatc acaaaaagga gctacttgct 1142341 ttctttcttg aaaaaactcg aattggtcat gataaggaag aatacaaaag gttccaatct 1142401 cttctttata agttggatat tgaatgttta gaatttgcta tatcgagatt ttctcatata 1142461 gatattatcc atgatcattc aaaatatgtt ccagccttta tccctttatt tgcagcatat 1142521 ctcaccatgt tctttaattt ttatgaaaaa cattggggag ctttatcttt tgctgctggt 1142581 acaattgctg ctattgtttg gataattgca gtagaaagaa aacatagaaa tcaagcaatt 1142641 tctattatga aaatatttga acaagtcaaa gagagaaaag tgaaagacag atctaaagac 1142701 tgaaaggaga aaatatgaat aaggataaat taaggtatgc aatcttaaaa gaaatttttg 1142761 aaggtaatac ccctttgtca gaaaacgata ttggagttac tgaagatcaa tttgatgatg 1142821 ctgtgaactt tttaaaacgc gaagggtata tcattggggt ccattattca gatgatagac 1142881 ctcatttata caaattagga cctgaactga cagagaaagg tgaaaactac ttgaaagaga 1142941 atggaacatg gtctaaggcc tataagacca ttaaagagat taaagattgg attaaataat 1143001 aagagcatcc tgcggggtgc tttttttgtt ccctgtaaac tgcttccggt aagtctcagg 1143061 atagacaatt ggcggttaac ggcttgagca cggtggtggt ttagagggaa tatcttttcc 1143121 aaaacaacac gaatcagaag ggggcggcgg tgaatgtaga tggccgaaaa gcacattcag 1143181 gcgtataagg attacgtcaa aggcatgaaa tacaaggacc ttgccgagaa atacggggtg 1143241 tcagtgaaca ccattaaatc gtggaagcag cggcatggtt gggaaaggaa aaagggtgca 1143301 cccattgaaa aaagtgtgca cacaaaaaaa ggcgggcaac cgggcaacaa aaatgcatta 1143361 gggaacaatg gcggcgcacc acagaagaat caaaatgctg tgactcacgg ctttttctct 1143421 aaattcttgc cagaagagac gcttgaaatc atggaagaga ttcaggagcg ttcgccagct 1143481 gatatgatat gggatcagat acagattcaa tatgcggcca ttcttcgggc gcaaaagatc 1143541 atgttcgttt ctgataagga agaaatgatc aaagagctga aaaagaaaag gtccctcata 1143601 tctgaggtca gcgaaattga agatgggctt gtcattagtt ttagtacgtg gtttcgctac 1143661 agactttaca gtgaaacaaa cacctaacac atttcacatt gcttcagatt gccttcaaac 1143721 ttgataatat aacttctaaa ccttcctata aaatgaaggt tttttatttg atttcaattt 1143781 ttaaatcctt tacatacagc gattgattaa ctcgagcaat caatgtcgca gttatattta 1143841 tttttcaaga aaatgttata atgaaaagcc ataaaatgat gggaggggga atttcgatgc 1143901 attacataac ggcatgttta aaaatcatca gtgataaaga ccttaatgag ataatgaagg 1143961 aattcaaaaa acttgaggaa gaaacgaaca aagaagaggg ttgtattaca ttccatgctt 1144021 atccgcttga gccatcagaa cgtaaaataa tgctttggga gatttgggaa aacgaagaag 1144081 ctgtgaaaat ccatttcaca aaaaaacaca caatagacgt tcaaaaacaa gaattaacgg 1144141 aagtagaatg gttaatgaaa agcaatgtga atgattgaaa ggctctttaa aaagagacat 1144201 tcaatgactt agtatcagcc acttgtgact aagtagtaaa ttgttgtcca actcttattt 1144261 tttctattta atattttttg agacgaaaat gtttttttaa gctgatttta aaatgtattc 1144321 aaagtcagct ctgtttgatt taatggatta tattatttgg atagcttgtt accatcataa 1144381 tggagatact ccttataaat tggaggttaa aataatgagt cattctcaag aaaaaattgc 1144441 actaattaca ggagcaagca gtcaagggga tattggtacg gctatttgtc gtaagttagc 1144501 ctcacagggt atacatatct tctttactca ctggaattct gatacggcct ggatagaaga 1144561 atttcaacaa gaaattttac gtatgggtgt ccgctgtgag gcaatgaaaa ttgatttatc 1144621 agatgcacat gctgcattca caatacatga aaaaatttca gataaattag gatatccttc 1144681 catccttatt aataatgcag ctcattccgc aagtgataat tatgtatcgt tagatgctaa 1144741 atcacttgat gagcattatg cggttaatat gagatcgaat tttcttcttt gtgttgaatt 1144801 cgcccgtcgg tttaaaaaat ctaatttaat atcaggaaga atcatcaata tgacatcagg 1144861 gcaggattta ggtcctttgc ctggggagtt agcgtatgca gcaactaaag gagctatttc 1144921 tgcatttact aggtcgttat cacaagaact tgcaccattg ggcatcactg ttaacgccgt 1144981 aaacccaggt ccaacagatt ctacatggat gacagatgaa ataagaaatt ttctttcacc 1145041 taaatttcca atggggcgta ttggcacacc agatgatgca gcacgaatga ttgcctttct 1145101 tgcaagtgat gaggctgaat ggataactgg acaaattatt cattcagaag gtggatttat 1145161 tcggggctaa gctaatgaaa cacggtatac accaatgtat gatgtattcc caaaactaaa 1145221 tctaaacttg aagcgaaaat aaggtccctt ctctttttag agggggacct tattttattc 1145281 atgcatgttt tgcatccaga aaatctggcg gataaagatt aataaaccgt tacatatact 1145341 tttccgaata ctgcagtacc tttaaacaaa gtaatcgtgg ctttcccttt tgatttagcc 1145401 gtcactaaac cattttgatc gacttcagca actttttggt tatcagtcca ataacgagta 1145461 gctgaattat ttttaacaga ataggtttct ccaactttta gaggtaaatt atagtcttga 1145521 atcttgataa catgtgtagg tgaaatagaa atgttcttta cttcagtagg tgtggagttt 1145581 atttcatgag ctgaagctac cccgctgacc gacagagcta acgcagaaat cgataaagca 1145641 gaaacaaccg tttttttgaa attcattttg aaacactcct ttaaagtttt ttgtcttgca 1145701 ctataacaat tcaataaaag taattatttt ccttgtaaat aaatgttaat aatatgtgaa 1145761 cgatcaattg atttgagcta agaatattgt gtgccctgca cagagtttgt atttatgatg 1145821 gaaaattgct gagagagaat ggccatcctt aaaatgttaa tagcacacat ttgatgggta 1145881 ttagtttgtt gagcgtgtgg aaattttgtt acctgcactt tatccccgaa gataccaaat 1145941 cacttttctt catcatgttc ttactttcgt actcatacat tagaaaatct tcgttctaaa 1146001 taggtgaaga attggagtat ttttatgaat ttctgctgaa tatacattac atagcaaact 1146061 caaagagtat aaaaatcgct tttttccgga agcttcggta aaaaacgaaa cttttgtctc 1146121 tatgattttg ttttataatg taaacggttt cttatatagt atacttatac tatcaatttg 1146181 ctcaagtaga tactgacagg aaggatagaa aaacagatgg aatacataaa tacaagacaa 1146241 aaagagattt tgtatctgtt gttatctgaa cctgatgact atttagttgt gcaagatttc 1146301 gcagataggg tacagtgttc tgaaaaaaca atccggaatg atttgaaagt gatcgaggat 1146361 tatctcaatg agcattctca tgcacagctt attcgaaaac cagggttggg cgtttattta 1146421 catatagaag aacaggaaag gacctggcta agccaacaat tacatactga acatttttct 1146481 tctaggcagc ggagcgataa ggaaagaatg ctgcacattg cttatgactt attaatgaat 1146541 ccgaagcctg tttccgcaaa agacattgcc gctcggcatt ttgtcaatcg atcttccatt 1146601 aaaaaggatt tatacgcagt agaagagtgg ctgaagcgtt ttgatctcac actggtttct 1146661 aggcagcggc ttggattaaa ggttgaaggg aacgaaagaa ataaaagaaa ggcattggca 1146721 agaatatctg atttgattca caatacagcg tttaccagcc aatttattaa aagtaagttt 1146781 ttacattatg aagtagactt tgtgacgaaa gaaatcaaat cactacaaaa aaagcattcc 1146841 ctctatttca cagacgaaac gtttgaaagt ttgttgctgc atacattgtt aatggtccgc 1146901 cgcatcaaaa tgaagcagcc gatttcattg tccccaaaag aaatggcggc agtaaaaaag 1146961 aagaaagaat atcaatggac atttgcttgt ttacagcggc ttgaaccggt ttttgcaatt 1147021 cgcttccctg aagaagaagc cgtgtactta acattacata tattgggcgg taaggttcgt 1147081 tatccattgc agacagaaga gaaccttgaa aatgctgtgc ttcctaaggt tgtagggcat 1147141 ttaatcaatc gtgtttcaga gctgaaaatg atggattttc acaaggatca ggatttgatc 1147201 aatggtttga acattcatct caatactgtg ctacaacggc tgagctacga tctttctgta 1147261 gcaaatccta tgctcaatga catcaaaaag atgtaccctt atttgttcca cctcatcatt 1147321 gatgttttgg aagacatcaa tcaaactttt gatcttcata ttcctgagga agaggcagca 1147381 tatttgacat tgcattttca ggcagcgatc gaacggatgc agggcagcag cgagacacat 1147441 aaaaaggcgg ttatcgtctg ccacatgggg attgggatgt cacaattgct gcggacaaaa 1147501 attgaacgga aatatcacca aatcgctgta atggcttgta ttgcaaaggc cgatttaaag 1147561 gattatatca aaaagcatga ggatattgat cttgtcatat ccaccattgc gctggagaat 1147621 ataacggttc cccatattgt tgtgtctccg cttttagagc ctggcgaaga gaagaaatta 1147681 agtgcgttta tacgtcagct gggcgaatca caccgccaaa aacaaaaaac gtttcagatg 1147741 ctgaacaata cgactccttt tttggttttt ttgcagcagg aggcggagca tcgctacaag 1147801 ttaatcgaac agctggcgac agctttgttt gagaaaggct atgttgataa ggactatgcg 1147861 gttcatgcgg tgatgaggga aaaaatgtcg gctacaaata ttgggtcagg cattgccatt 1147921 cctcatgcaa acgctaaatt tattaaacaa tcagcaatcg cgattgccac attaaaggag 1147981 ccgcttgaat ggggaaatga aaaagtttcg ctcgttttta tgctggctgt caaacacgag 1148041 gatcaaacta tgacaaagca gctgtttagc gagctttcat atcttagcga gcagccggcc 1148101 ttcgtccaga agctgacgaa agaaaccaat gtcatgacat ttttatctca tttggattat 1148161 taaaagcagg gattattcct tgcttttttt gttcatggca gggcttgaga aataaatttg 1148221 cgagtgaaga cgcctattct ccagcaatga tctaaataaa ataagagttt aatagttgga 1148281 gaagaaatgt tacactcttt tctgtatatg gtaaagaatg aaaaaacacg attcggttgg 1148341 tagtccggat gcatgattga gaatgtcagt aaccttcccc tcctcgggat gtccatcatt 1148401 ctttaatatc ttttatgagg agggaatcgt tatgaaatta acgatttact acgatggtca 1148461 gttttgggta ggcgttgttg aagttgtgga caatggaaag ctaagagcct ttcgtcatct 1148521 ttttggcaaa gagccgaggg attctgaagt attagagttt gttcataacc aacttttgaa 1148581 tatgatggcc caagctgagc aggaaggagt gcgtttacaa ggcaggcgtc aaaaaaagat 1148641 caatccaaaa agattgcagc gccaggtttc aaaagagttg aaaaacgccg gagtaacttc 1148701 taaagctcaa gaggcgataa agctagagct tgaagcaaga aagcaaaaga aaaaacaaat 1148761 aatgaaagaa caacgagaac atgtaaaaga gcaaaggtat atgctcaaaa agcaaaaagc 1148821 gaaaaagaag cacagaggta aataatccaa acaaaagcag gcgcagtgcc tgcttttgta 1148881 attaaggact ctactttgta acatatatcc aatgtttata ctccgctgat ttatgattca 1148941 atataaaccc taacttctcc aaggtttttt gtgagcctag attatcatgt tcgcatcttg 1149001 cggtgatccg ggatactgtt tctcggctta atgcccagtt tattagtttt tgggcggctt 1149061 ccacacaata acctttgcgg cgatgacttt tatttgttgc aaaaccgatt tcaatcatgc 1149121 cattttcgtc tgggtcacct aaaaatccag ttcccccaac aatttcataa ttgtccttct 1149181 ttacaataat ccatgaatca aatccttttg ttccattgtt tttgactaaa atctcgcgga 1149241 aataaggtat cgcttcaaaa aaatcagaat ttggccattc accatttgtt tcatagccta 1149301 attctttgat agcctgatga tcttgtttag acgcggcgtc aagaagggga atatcaatcg 1149361 tttgtaatcg taatcgattc gtttcaagga gaaccatata tttaatcctc ttttcttttt 1149421 actgggaata atgataacat ataacaattt tctctggtac cttggcagta gagaaagatg 1149481 aaaaaattga gggggattga aagagtgaca ggtgagagtt tgcccagacc aaaaacgggt 1149541 aggaaaatgc tgatgttaat gtgtccctac ccgtttttct gttcctgaat gcagggtttc 1149601 tgataacatg ttgtgctacc ttttcgcaat caaataaagc gatatggctc tttgggtttg 1149661 cacaggatta tgaatgataa tgacccattg gtttcttcgt cttggaaagc ttgctaccgc 1149721 atacaatgga gcagtatcgc gcggagtgaa cccaccattt atcacgttga tatctcttcc 1149781 ttcaagatga caaactaagt attcacctgg attgatgacc tgttggttcg tccatgcgta 1149841 agaataaaag ccgtctccaa gatcttcggt ggaagatggg gggacaaagc catctacagt 1149901 caatgtgatt tctcttcttc gctgtctttc tgaaaagtct ggacttcttt gagggttatg 1149961 agtatgtgaa aagtaaggaa ttaacgcagg gccataaaag taatgataca aagcaaccac 1150021 tcctttattt tccattcata caaattgtat gtgggagtta tttgttcatt cctgttttgt 1150081 tccatgtaga ctaataatgg gctataggcg tccaaggaaa tcaatttgtc cttccgttga 1150141 ttcaatgcta gtaaccttga aaatgcaggt taggatgata gaatttacat attactgcaa 1150201 gaagttagac atacatcatt ttgatagtgg gtgaaaacaa tggcgaaaaa aatggcaaaa 1150261 acaaatgcgg ttcgtctgat agaacagcag aacatctctt atgaggtatt agggtataaa 1150321 acagacggcc agccggtaga tggcatctct gttgcggaaa aaatcggtta ttctttgaaa 1150381 tatgtatata aaacgttggt tgcagcagca ggaacaaatc attattatgt ctttgttgta 1150441 cccgttgcag aagagttaga tgtaaaaaag gcagcaaagg tgacagggga aaagaaaata 1150501 gaaatgattg caatgaagga gctgttagcg gtaactggct atcttcgcgg cggctgctcg 1150561 ccaattggca tgaaaaaatt gttcccgacc tatattgatg catctgcaga aacgcttgat 1150621 tttattattg tcagtgcagg gaaaatcggt atgcagctaa agttggcgcc acaagattta 1150681 gccagatcat gtgatgccgc atttgcagaa attgtataga tgcagatata ggggaacgaa 1150741 aaagcttagt catatcgatt aagctttttc cgcatccctt tcaaatatga tttcaaaata 1150801 agcagctgcc ccatacccat ctatactggg agcgaaaatc tgaacgaatc tccagcctct 1150861 tttcgcataa tcatggatga tttgctggta gtcttcttta ggccttcttc tcatcgtact 1150921 cagctcaact cttacgaatt catattcttt catcgtttga tccctcctat taaggtatac 1150981 gtaaaatgga gcgagaagtt ccgaaaacct aggttaaggt cggaaagtat atttcactca 1151041 ctaaacaaat ccatttatgc ctgatgcctg catgcatctg ggaagagtta aggggctata 1151101 aaaacgaatt ttaccgggtc agcagtccaa atgaatctct tgcttattgc atttgactga 1151161 gtatataagt aaaaaaagag cggccagaac atataagaag gagatgatca ttaacgcact 1151221 cataacaggg tagtgtttag cggagtagat gaaaaaatca agctgtgaaa tttgtttggg 1151281 gctgctgacg gcatcaattc cattaagcag ttttgagagt ttagcagtat agttccaatc 1151341 aaatcgatct gaaacaagct cgcttccttg ataccaatta acagcagcta aaaacagaaa 1151401 taccataata gaaaatccaa gctgaacaac taaaaatatt cccttcactt ttgtatgacc 1151461 tccaaatcta tgaatatggg aaaatcaaac aatatattac caccgtatgg gttattcttg 1151521 caatttcact tccatacaac tcaaacgcaa gtctattttt ttgtttgttt ttggcttata 1151581 atacctgatg atggaaaaag agtgcgggtt tatagattag agaaacaaat gtatttctta 1151641 gcatttttta tttgtggaga gagtatagaa gcattcgatt agatctgctt tttcacagaa 1151701 acggttttca tctgtttgcc tgagctttac aattggctgg caaaaaaaca atgatttctt 1151761 tcaatcaaaa catgcaacga tgcgacacat tttatatctt gatgacttat ttcattgcct 1151821 ttaagtcatc ctatcgagaa agcgatggta ttttatgaac aaagaaaccc taaaaaacat 1151881 actcatgatt ttttcaatat gcgcaacact ccgagaaacc gatggtatgc gcatagctga 1151941 tagctggatt ttgagtgaga ttatacgatt tttgatttgc atggttgtgt tttttgccat 1152001 gacatttcta ttagatgctg tttttccaaa caaaaaagag tcacattaat gtgtggctct 1152061 ttttgcatca tctgatcaga aacatcataa atgaatcgat catcatgatg aagaacagca 1152121 agcaaaaata aataagcgag tagacaaaca tatcctttgc ccacttcacg tcatcgtctg 1152181 ttttgaatcc tttgatgctt tttttgatcc atatgcctcc gagaaccaag gcggctaaga 1152241 aataaaatgg gcttatatgg ccggtgccga gagagaaagg aaataatagc gtgaccggca 1152301 ccaggacggc aatatattgc atcattttta tttttgttac atgattgcct ttgactactg 1152361 gcaagagcgg aacgccagca gcgcgatatt cctctttgcg tcttatccca atcgcccaaa 1152421 aatgcggcgg ctgccacaga aacataatcg tgtacaacag cactgctgtc atactgaagt 1152481 caccggttac ggcacaatac cccatcaatg gcggcgcagc tcctgggaag ctcccgacaa 1152541 atgtgctcca cacagacgtt cgtttcaccc ataccgtata gatgatcgca taaaaaataa 1152601 aggcggccag tccgagaaag gccgttaatg gattgaggga ataaagcatg gcaagacctg 1152661 cgattcctaa aacagagcca tatgttaaga tcatggctgg cggcattttc cctgtgaccg 1152721 aggccctgct gcgagttcgt gccatttttg cgtccatatg ccgatcaaaa tagttgttat 1152781 agacagtgcc ggaagccatc acaaacgcgg ttcccaacat tgctgttacc attgtcatca 1152841 aaaaagccaa gccggttaac gttttttctg cgcttgcaaa cgcgatccaa aacccgccga 1152901 aggctgctat cgagtttgat atgataatgc ccggctttgc aagtttgata aaatcgtaaa 1152961 tggttacccg gttcgaagct tttatgtatt ttgtttcaga tatggctgca gaatctcttg 1153021 tattctccaa aaatagacgc ctcccccaaa actgcatgct tttgttatcg taacaagagg 1153081 gggacagaat cacaattatt tcccatattt gtcatgatat tgtcattttt aaaacaaaaa 1153141 aatggggagc tggactgccc ccattttgat atgtggcgac tagtaaccgt aacctccccc 1153201 atatcctccg ccataacctc cgccgtaacc gtaccaaggg tagtaaggcg gtcgcgggcg 1153261 cgggtagtaa taaggcgggc gcggataaaa cgggtagaac ggataatacg gtcttggata 1153321 ataataaggc ggataaaatg gcggtctcgg acgcggataa taataaggct gtctttcatc 1153381 ataaggggta atttgttcaa atgactgttc attcaaaggg taatccaaga ggaaaacctc 1153441 cctagctttt tttattcctt ttaccatatt cctgatgctt aagttgggtg tatgtacatt 1153501 catgaaattc ggtttttttt atgatgaaat tccttaaaaa ggattgacat gaacttctaa 1153561 atctcatagt attacaaatg tgaaataaat gttactacaa tgttacaaaa acatttctaa 1153621 atagatacag ttccaactga tgaagagtaa atcgaaatgg ctacgaaaga aggagttttt 1153681 gttgttggca aaaagaatca aatggtttca tgtattaata gcagttgtat gtgtggtggg 1153741 ccttatcggc tttttccata atcattcatt gaaaaaagaa acggtcatga ataaagtaag 1153801 aactgattct caatatggga atgttgagat cgcaacgctt gtgaatgacg ggaaaacttt 1153861 taattacgcg gtaaactatc ctgttttcaa aaatgaaaaa atggattcgg cattaaaaag 1153921 attcgcagaa aaagaggttc gtcaatttca aaaggaaaca aaggacgttg accaagagca 1153981 tacgacaaaa cgcaacgaat taaatgttga ttataaaatt gtccattatg ccaaacagac 1154041 agtggcgatt gtatttaatg aatataaata catcggcggg gcacacgggc aaaccgtgaa 1154101 aaaaacgttt aactatgatt ttagtaaaca agcgtttctt tccattgatg atattttcaa 1154161 agaggacgct gactacttac ataagctttc gttaatcgct tatcacgagc tgaaaaagaa 1154221 taaggacatt gccgcggacg atgcactgtt aaaggaaggg acggctccga aaaaagaaaa 1154281 tttcagccgc tttgccatca aggaggatta tatcgaactt tactttgaca catatcaggt 1154341 tgcagcaggc tatcttggag agcaatcgat tgccattaag aaaagtcttt tgaaagacat 1154401 tctgaaagaa caatatattg ataaagcaaa aaataaaaat aaaatcaaag aacaaaagcc 1154461 gaagcatgaa gtgatttctt tacccaaaga ggaaacagtt gatccaaatc aaaaagtcat 1154521 tgcgcttact ttcgacgacg gcccgaatcc tgcgacaaca aatcagattc tagactcctt 1154581 gaagaaatat aagggtcatg ccacgttttt tgttttgggg agcagagttc aatattatcc 1154641 ggaaacgcta ataagaatgc tgaaagaagg aaatgaggtt gggaaccatt catggagcca 1154701 tccgcttctc acaaggcttt cagtgaaaga agcgttaaag cagatcaatg atacgcaaga 1154761 catcattgaa aaaataagcg gatatcgtcc gacgcttgta agacccccat acggcggcat 1154821 taatgatgaa ctgcggagtc aaatgaaaat ggatgttgcg ttatgggatg ttgacccgga 1154881 agattggaaa gaccgtaaca aaaaaacaat tgttgaccgt gtcatgaatc aggcgggaga 1154941 tggaagaacc attttgattc acgatattta ccgcacctct gctgatgcgg ccgatgaaat 1155001 tataaaaaag ctcaccgatc aaggctatca attggtgaca gtttctcagc ttgaagaggt 1155061 taaaaaacaa agagaagcga aataaattag aaaaggctgt ccgtacggac agcctttttt 1155121 ctatttaata agagcctgtg gtggcccaaa catttaagtt tggtcctgaa tacttgccga 1155181 aagcgtaaga agtccttgga tctaaatcat ataccatcgg tgtatagcaa gacttttggc 1155241 cggccaccgc ttttccattg ccgcctgcag aatcacaatt atatcttttt ccgtctgtgt 1155301 tccgggtaat ctccgcattt gcttcatagc cagacgtcaa tgtattattc atcgtgattt 1155361 ttgcccaagc cgttttacat gtactgctga atttaagctc gactactccg atgacttgat 1155421 tgctggcatt cactaagttt gaggattttt ttgtagagcc gctggacgca caatcattgt 1155481 aataagggct ttttccatcg taggcatggg tttccgcctt ggcgggtgca cctttgacgg 1155541 caaaaacaaa tactactgcg aataacacca atgaagcctt cataaacagt cttttcaatt 1155601 tatgacctcc ttaatatggc aaacaataaa tcatatggag gaacaatcaa aacatgcatg 1155661 cttttttgtg aacaataaag gcggccggga ggatggagtt cttggccgcc tctggtatga 1155721 ggttatgctt ttacatcaat ggtttgtccg agagttggat gttgaatcat ctttaaggtt 1155781 tgatcggcat tttgctgggc ggtgtccagc ctttttttcg ttaaagcaat atttacattc 1155841 tgggcaaggg atgcttgatg catcgcaacc gataaagcag gaatatccat ggttccacct 1155901 cctatgcctt acctatcggc gggtttgtat gattttacag tgaaaaatgg cttaatttct 1155961 cttgttgacc cttacgctgc ggcatatcgt atgtttttga caaggaggga atcaggatga 1156021 atctagtaat ggaaaagacc tttgagcaat acgaaaagct gttttcaatg gaagaacaga 1156081 aaagagaaga tgtatttcgg tatacgatga tgaggccgtt tgaaaagatg tggaccgcca 1156141 tccaagttcc gctgaaagcg aaggagccaa acggctatga tgtgatcatg gctgcgaaaa 1156201 tgctgggcta tttggatgtc cgtgatgctg aaagcggcca gaaagcacta caaatactga 1156261 aagaatcaca tgtttcagag acagctgaat ctgcacttcg gcaatgcata ttttttgctg 1156321 agcgcgaaca gctgcgggtg aatgcaaagg agatcaaatt cggcctttat atcgctgatc 1156381 caaataagct tcagctgcaa aaaggctact gcgggtttgg cgggataccg ggctttattc 1156441 atgtatggat taatccgaac agttataacc tgccaaggat tccttccatt attgctcatg 1156501 agtttcatca taatgtgcgg ttttcgtata tagattttca tcatggctct gtaagtgtcg 1156561 gggattatct tgtgattgaa ggattggcgg aatcattcgc cagagagctg tttggtacgg 1156621 aacgattggg cccttgggta actcgttttg atcatgaaga cttgcaatat tccattgatg 1156681 tgattaatga ggtgctggat gtgaaaggat tttcggaagt cagccgttat atgtttggtg 1156741 atccaattgc taacgaccaa ggctttaagc ctgcaggttt atcggctttt gcgggttatg 1156801 cagttggcta tcatgccgtt cagtcattta tgaatcaaca tcatatcacg ataagcgagg 1156861 ccacacgttt ggatgcgaag accattattt ctcaatgcgg tctgttttct acatgaaaaa 1156921 agcgtcacat acagcggcgc tttttgattc ccaaaaccag cagttctatg gcggcacagg 1156981 cggcaattcc gattgtatat gcttcgatat cgctccataa aaaaccgtac cctagtacaa 1157041 gcccgccaag agaagtatct ctaatctggt cgatccattc ggcatgatag agctggctga 1157101 attcaatgac aaaacagaaa gaaagactga taatgcccgt tatcattgtc ttcagcttcc 1157161 gaaatagaaa tccgcatccc gtgaagatca tggcggccca caacgagtct cccagataag 1157221 tattgagggt atcaggaaga acactggaga atgctctgga tccaagcccc agcccaatga 1157281 tcagtatggt gaaaactgca tatatccaac gatttcgctt cattgcgaat tgataccccg 1157341 tctctgcttc atctccctgt attgtaagga atatagcttt tatttgtcca ctaaaaaagc 1157401 ggctgaatag ccgcgtaggg tgtttatttt gcttttaggt ttacatggtc ggctgtctga 1157461 tccgtgccta ttacaaaatg gagttcatag cggcctgtat catatacata atcgatttca 1157521 tcggtaaacg ggacggttaa cacccgattt actggtccta attgcttctg cagcacttcc 1157581 ggcgtaactc cgcctaaatt cagctgccgt tccacaccgg ttccaaagta gcggatttct 1157641 gaaattgtca tgtctttatg ataggaaaat ccgtagcccg gctgtcccat attccagtga 1157701 tataaatcaa atcgattgtc tcccccgact ggtctttccg gttccccaaa cgcagcgtgg 1157761 acatcccctt ttgtgctttt gttaatggta aggccttgcg cctgctgagg catttcccct 1157821 ttataggcgg tgttatagag gtttttgaca agctcagcgg ctgattgatt cgtgttttct 1157881 gagagtgtgt ttgtttgagc tgcggccttt gccggtgctg aaaaggacgc agccccaaag 1157941 ccggtaaaac agcttgttac tgctgctgcc gcggttatag cagacattgt ctttttcatg 1158001 ttaatccctc ctaattgatc taccattccg tttccccgtg tttttgcaac gaaacatgtg 1158061 agtgcgcttt gtatgtttta ttgagttgtt gtaagggaac tgaaataggt aattcggtat 1158121 ataaagcaag aaaggggaat ggagatggct ggcaagaaaa caatcacaat aaacggcgtt 1158181 gaaatggaag cgtccgagga acagacggtg ctgcagcttt tgaataacag ctcgattgaa 1158241 gtgccgcaag tttgctatca tccaagctta gggccgattg agacatgtga tacgtgcatc 1158301 gtcagcatca atggtgagct gaagaggtcg tgctccgctg aattaaagga tggggatgtc 1158361 attgatacgc tctcacctga cgtgaaaaaa gcgcaggtca tcgggatgga caagatttta 1158421 tataatcatg agctttattg tacagtttgc gattacaaca atgggggatg cgaaatacat 1158481 aatacggtga aggaaatgaa aatcaatcac caaagcattc cgtttgatca caagccatac 1158541 cataaggatg aatcccatcc gttttatcgg tatgatccag atcaatgtat attgtgcgga 1158601 cgctgtgttg aggcatgcca agacgttcag gtaactgaaa cgctgaccat tgactgggag 1158661 cggaaacgcc cgcgcgtcat ttgggataac gacgtgccga tcaatgagtc gtcatgtgtg 1158721 tcatgcggcc attgttcaac ggtctgtccg tgcaacgcga tgatggaaaa aggaatggaa 1158781 ggggaagccg gatatttaac aggcatcaat aacgaaacgc tgcgaccgat gatcgagatc 1158841 acgaaaggcg tagagacagg ctacggctcg attctcgcga tttctgatat ggaatcggcc 1158901 atgcgtgatg aacgaatcaa aaaaacgaaa accgtctgca cgtattgcgg cgtcggctgc 1158961 agctttgatg tctggacaaa gggcagagac attctgaaag tagagccgca ggaggaagcg 1159021 cctgccaacg gcatttctac ttgtgtgaaa ggcaagttcg gctgggattt cgttaacagc 1159081 gaagaacgcc tgacaaagcc gctgatccgt gaaggcgatc atttccgtga agcagagtgg 1159141 gaggaggcgt tattgctgat cgccagcaag ttcactgaat taaaagaggc gtttggcccg 1159201 gattctctcg cttttattac atcttctaaa tgtacaaatg aagaatccta tcttatgcaa 1159261 aagctggcca gaggggtcat tggcacaaat aatgtggaca actgctctcg ctattgccaa 1159321 tctcctgcga ctgccggcct gttccggaca gtcggctatg gcggtgattc aggatcaatt 1159381 acagatatcg cgcaagcgga ccttgttttg attatcggtt cgaacacgtc tgagtcgcat 1159441 ccagtcttat ccactcggat taaacgggct cataagctga gagggcagaa agtgatcgtc 1159501 gcggatatca gaaagcacga aatggcagag cgctcagatt tatttgtcca gccgcgtgcc 1159561 ggatcggata tcgtctggct gaatgcgatc gccaaatatt taatagaaaa cggcaaggcc 1159621 gatgaacgat ttttgagaga aagagtgaac ggacgggatg aatatgtaaa aagcctcgcg 1159681 ccgtacacac ttgaatatgc tgaggagaaa accgggattg atcaagaaac ccttatccaa 1159741 atggcagaga tgatcgggca agctgacagt gtgtgcgcat tgtgggcgat gggcgtgaca 1159801 cagcatattg gaggaagcga cacgagcacg gcgatctcta atctgctgct tgtgacagga 1159861 aactacggaa aaccgggagc aggttcttac ccattgcgcg gccataacaa cgtgcaggga 1159921 gcaagtgact ttgggagtat gcctgacaga ctaccgggct atgaaaaagt gacggacgaa 1159981 caagtccgcc aaaaatacga gcgtgtgtgg ggtgtgccgc tgccgaagga gccgggtatg 1160041 accaaccacg aaatgattga aaaaatccat tccggacagt tgaaagcgat gtatgtaaaa 1160101 ggtgaagaaa tgggccttgt cgactccaat atcaatcatg tacacgctgc atatgaaaag 1160161 cttgatttct ttgtggtgca ggacattttc ctttcacgta cagcggagtt tgctgatgtg 1160221 gttcttcctg cgagcccgag ccttgaaaaa gaaggaacgt ttacaaacac agaacgccgg 1160281 attcagcgtt tgtatcaggt atttgaaccg ctgggtgaat caaagccgga ttggcagatt 1160341 attatggagg ttgccaataa gcttggcgcc ggctggctct atgagcatcc tgcagacatt 1160401 atggaggaag cagccaagct gtcgccgatt tatgccggtg tcacctatga acgtcttgag 1160461 ggctataatt ccctgcaatg gcctgtaaac gctgatggaa aggattcgcc tttactcttt 1160521 acagagcgct tccctttccc agacggcaag gccattctct accctgtcca gtggacagag 1160581 cctaaggaat tcggtgagga atatgatatc catgtcaaca atgggcggct cttggagcac 1160641 ttccacgaag ggaacctgac ttacaaatca aaagggattt cggagaaaac accggaagtg 1160701 ttcttagaaa tttctcctga gcttgcggca gaacgaggga ttcaggacgg aaccctcgtc 1160761 agactcacat cgcctttcgg aaatgtcaaa gtgaagtgcc tgattactga tcgagtcaaa 1160821 gggaaggaag tatatctgcc aatgaacgat tcaggggaag cggcgatcaa cctgttaaca 1160881 ggcagccatg ccgataagga taccgatacg cctgcttaca aagaaacatc ggccaagatg 1160941 gaaattttga agcacgacgg aatcagcccg ctgcctaaga tcaaccaccg caacggcaat 1161001 ccgcagccgc aaatcggtgt gcaggttcat aagaaatggg cgcggaagga ttatattttc 1161061 cctggtgacg ctgtgaaaag ggggatgggc cataatggct aaagcgatta aacgaatcca 1161121 aaaaatcgag gtaacagaag aggatcagcg aaagcgtgat ttgcgggaaa ttgaagatgc 1161181 tctaattgac cacaaagaag cgattctcga aacattgcat atgctgggcc atatgaacga 1161241 gcgcggggtc ctgccgttgc tccgcggcct ttttggtcaa ggggataaag ttcttgatat 1161301 cctggtgaaa aaggcagata cagaggaaac agccaatacg ctgaaaaatc tgcttcttct 1161361 gtttggaaca ctcggcatgc tggacgtgaa gcagctggag cctctcattt tgaaagtgaa 1161421 tgcgggtgtg gcaagcgctg tagagcagaa aaacagtgaa gaaaagacag gttattttga 1161481 tattatccgc tcgctaaaag acccggaaat caacaaatca attacactgc tcttttcctt 1161541 tttaaaagga atgggacaag atacaaagga gctggaacgc acgacgcagc ctccggaaca 1161601 ccaaaaacat catcaggaac cccgagagaa aagaggaatg aataagcgag attgacctcc 1161661 cacccgagcg gcttcagcca gctcgggttt tttgatgaaa aggtctaatg gactagtaaa 1161721 aaatattcaa atactaggaa gaagtaagat tgtgatgaat gagatagaaa taatcgttac 1161781 tttcttacct gttaagaaaa gggaaaatct gattataata gaaatcgatt actttagatg 1161841 ggggaacaat catgaaaaaa gtcttattac tattatttgt cttgacgatc gggttagcgc 1161901 tttctgcgtg cagccaatcg agcgatgcgt cagagaagga aaaaccgaaa gagaaaaaat 1161961 cgcaagaaga gcttgaaaag gaacttgata aggaattgaa aaaaggcggt gagccgaaga 1162021 ccaaaaaaga tgatcaaata cataaaatag gagaaacatt taaagcagga catacgaatt 1162081 ttacagtgaa taaagttgat agagtgcaaa aaggtgaata tatgaatgtt ggcggagctg 1162141 taaatgagga gacaaaaaca ataaaagatg atgaggaacg gcttattata gaagttacga 1162201 tggaaaatat aggggaagat tcaataagct acaattttat cgggtttgat ttaagagata 1162261 agaatgatca atcagtgcgg cctgtttttt ctatagaaga gaagggcaga atccttatgg 1162321 gaggaacact agtatcgggg aaaaaggtta caggtgtact cagttatgtc atccctaaag 1162381 gagaacagaa acattacaca ctggtatata atccgttttt agctgataca aatagcagta 1162441 atacagaaga gagagtaaag gacgatattg attacttggt gaagttagat tagatgctaa 1162501 tttacagttg cacgtttttc atctgtggaa aacgtgcatt ttttatagcg aaacttgact 1162561 tgaaaggatg agtgataaaa gtgcaaacca aatggctgga acgggcacag cggattcggg 1162621 cgatcgccca agcggggctt gctttttcca aggatgtgta cgacagggag aggtacgaag 1162681 agctaatgaa gcttagcgcg gaaatgatgg cggattactc ggagaaggac attgaagtta 1162741 tcactgattt atggcaaggc gagaagggct atccaacacc gaaagcggat gttcgcggcg 1162801 ctgtattcag agagaatcag attttgcttg tccgggagaa gcatgatgag ctgtggtcgc 1162861 tgccgggcgg attttgcgag attggtttat cgccggctga aaacgttgtc aaggaaatca 1162921 aagaagagtc ggggtacgat acagagccgt ctcgattgct ggccgtgcta gacagccata 1162981 aacactctca tccccctcag ccttatcact attataaaat cttcatcgca tgcagcatga 1163041 cggacgggca gggggaaaca gggatcgaga cgaatcatgc cgcttttttt ccggaagaca 1163101 gactcccgcc gctttctcct aaacgaaaca caccctcaca gcttagcatg ctgtttgact 1163161 ttttgcgcca tccggacaag aaaacgatat ttgactaaaa aagaaagagc ctgtgggctc 1163221 tttctttttt ataatgtaat gtgtttttcg ttggcgagtt tcagaagggt caaaatagaa 1163281 tcggcttgtt tatggccgag tttttgcttt aatttgtttt cttcaactaa tcggctgcca 1163341 taaattttga cggaggcttt gtcgacgaca gtatgccagt tttcctgttt ttttccctca 1163401 acaagcggtt tttcatgtct ctcagaaaaa gagaacacaa agagtacgaa tgcaagtgaa 1163461 agtaggattc cgacaacttg ttttttgtaa tcagtctgtg ctgccacgtt gttctctcct 1163521 tcacctttta ccttctattt aatcatagaa ccaaattatt ttacataatg ggaaagtcat 1163581 ttttggagtt agtgcatttg gttgaaaaca gagacgtttt ttgagcggag cggtgcaatt 1163641 gaatccatat tggatttgcg tgcttatgcc taaggtcacg ttgtgagcca aaacagcagt 1163701 gcagaataga aaaaaattga aagattatgg taagatgaac gaaattcgag ggggaatata 1163761 tgatgcctgc atcgaacatc gtgatcgcct gcctgctgtt atcaatttaa ttatttgtgg 1163821 tagtccctct ctttttcgaa agcgggaggt gaagtggaac attaattgct gaattctttc 1163881 aaggggagtg accgtacatg aatgtgttaa accgccggca agccttgcag cgagcgctgc 1163941 tcaatgggaa aaacaaacag gatgcgtatc atccgtttcc atggtatgaa tcgatgagaa 1164001 aggatgcgcc tgtttccttt gatgaagaaa accaagtgtg gagcgttttt ctttatgatg 1164061 atgtcaaaaa agttgttggg gataaagagt tgttttccag ttgcatgccg cagcagacaa 1164121 gctctattgg aaattccatc attaacatgg acccgccgaa gcatacaaaa atccgttcag 1164181 tcgtgaacaa agcctttact ccgcgcgtga tgaagcaatg ggaaccgaga attcaagaaa 1164241 tcacagatga actgattcaa aaatttcagg ggcgcagtga gtttgacctt gttcacgatt 1164301 tttcataccc gcttccggtt attgtgatat ctgagctgct gggagtgcct tcagcgcata 1164361 tggaacagtt taaagcatgg tctgatcttc tggtcagtac accgaaggat aaaagtgaag 1164421 aagctgaaaa agcctttttg gaagaacgag ataagtgtga ggaagaactg gccgcgtttt 1164481 ttgccggcat catagaagaa aagcgaaaca aaccggaaca ggatattatt tctattttag 1164541 tggaagcgga agaaacaggc gagaagctgt ccggtgaaga gctgattccg ttttgcacgc 1164601 tgctgctggt ggccggaaat gaaaccacta caaacctgat ttcaaatgcg atgtacagca 1164661 tattagaaac gccaggcgtt tacgaggaac tgcgcagcca tcctgaactg atgcctcagg 1164721 cagtggagga agccttgcgt ttcagagcgc cggccccggt tttgaggcgc attgccaagc 1164781 gggatacgga gatcgggggg cacctgatta aagaaggtga tatggttttg gcgtttgtgg 1164841 catcggcaaa tcgtgatgaa gcaaagtttg acagaccgca catgtttgat atccgccgcc 1164901 atcccaatcc gcatattgcg tttggccacg gcatccattt ttgccttggg gccccgcttg 1164961 cccgtcttga agcaaatatc gcgttaacgt ctttgatttc tgcttttcct catatggagt 1165021 gcgtcagtat cactccgatt gaaaacagtg tgatatacgg attaaagagc ttccgtgtga 1165081 aaatgtaata gataaggaga ctggagattc atgaaaaagt accatatttc gatgatcaat 1165141 atcccggcgt acggacatgt caatcctacg cttgctttag tagagaagct ttgtgagaaa 1165201 gggcaccgtg tcacgtacgc gacgactgag gagtttgcgc ccgctgttca gcaagccggt 1165261 ggagaagcat tgatctatca tacatccttg aatattgatc ctaagcaaat cagggagatg 1165321 atggaaaaga atgacgcgcc cctcagcctt ttgaaagaat cactcagcat tctgccgcag 1165381 cttgaggagt tatataagga tgatcagcct gatctgatca tctatgactt tgttgcgctg 1165441 gctggtaaat tgtttgctga aaagcttaat gttccggtca ttaagctctg ttcgtcatat 1165501 gcccaaaatg aatcctttca gttaggaaat gaagacatgc tgaaaaaaat aagagaagca 1165561 gaggctgaat ttaaagccta cttggagcaa gagaagttgc cggctgtttc atttgaacag 1165621 ttagctgtgc cggaagcatt aaatattgtc tttatgccga agtcttttca gattcagcat 1165681 gagacgttcg atgaccgttt ctgttttgtc ggcccctctc tcggagaacg gaaggaaaaa 1165741 gaaagcctgt tgattgacaa ggatgatcgc ccgcttatgc tgatttcttt gggtacggcg 1165801 tttaacgcat ggccggaatt ttacaagatg tgcatcaagg catttcggga ttcttcatgg 1165861 caagtgatca tgtcggttgg gaaaacgatt gatccagaaa gcttggagga tattcctgct 1165921 aactttacca ttcgccaaag tgtgccgcag cttgaggtgt tagagaaagc tgatttgttc 1165981 atctctcatg gcgggatgaa cagtacgatg gaagcgatga acgcaggtgt gccgcttgtc 1166041 gtcattccgc aaatgtatga gcaggagctc actgcaaatc gggttgatga attaggcctt 1166101 ggcgtttatt tgccgaaaga ggaagtgact gtttccagcc tgcaggaagc ggttcaggct 1166161 gtatccagtg atcaagagct gctcagccgc gtcaagaata tgcaaaagga tgtaaaagaa 1166221 gctggcggag cggagcgtgc ggcagctgag attgaagcgt ttatgaaaaa atccgctgtc 1166281 ccgcagtaaa aacataaaaa ccgaaatcaa tttgatttcg gttttctgtt taaatatttt 1166341 ttttcatccc gcatctccgg cattctctaa gaaattttcc gccttttaca gagcttttga 1166401 acagtgtgta atcacagttg tcgcagcgcc cgctgcgggc atccggatat tcattgaatt 1166461 cgtaaacaat cgatgtatcg tagccttttg tttcatattc ttcttttttg gtttccatgt 1166521 cgatcctccg ttacaagacg tgtctgctgt ttatcttaca gcaagcttcc ggcgtattca 1166581 atggatttta ggaggttggg tttatcttga tttctccctt ggtttgcgcc aaaatagctt 1166641 tattaagctt atatacataa aaagcctatg caaagaggag aggaaacggg tatgggaaaa 1166701 gggttacttg gaaaacgcgt ggcaatcggt ggctcacgaa aaacggaaga aattagtaca 1166761 atcattgaaa aacagggcgg aatacctgtc atccggcctc tccaaggtac agtttactta 1166821 gcagagaagc aggtggagcc ggatttgcgg acgtttgcgg aagaaaaagc tgactgggtc 1166881 attttcacga caggcatcgg gttggagact cttgtcgata tggcagagaa aattggactg 1166941 aaagatgagt ttctgcaggc cattcgccaa gcgaaagcgg catgccgggg atacaaaacg 1167001 ctgtctgcgc tgaaaaagct tggaatcaca ccggaagctt cggatgaaga cgggacaaca 1167061 agaggcttaa tccgttcctt ggagcctcac gacttttcag gaaaaacagt catggtgcag 1167121 cttcatggcg aaaaagcgcc ggctctcatg gcatttcttg aagaaaaagg cgcgtctgtc 1167181 ctgccgattc tgccttatca gcacatcccg ccggaggagg aaacggtgga gcggttatgc 1167241 cgagagctga tgaacgatga ggtcgatgcc gtttgtttta caacggccat tcaggttcgt 1167301 tccctgtttg attttgccaa ggggcgaggt tatatcaatg aagtgaagaa ggtattcgaa 1167361 gaacgcgcca tcgcagctgc tgtcggaaaa gtgactgctg aagcactgcg ggaagagggc 1167421 attacgagac tgcttgcgcc agagattgag cggatgggtg cgatgattgt tgagctggcc 1167481 aagtattatg aagaaaagga ataacaagta caaaaagccg cttttccctc ggaaagcggc 1167541 ttttgtctgt cattcatttt gcttcagctg ctgatgaacg gtgaataatg atgggtatgt 1167601 cagcacgctt aagattacac aagtcagcgc ggctgaggcc atcgttgtaa acacgattaa 1167661 gagttgaaag cgtactgcct gaatcgggtc cgcgccggct agaatctggc cagtcatcat 1167721 gccgggaagc tggacaagac ccagtgtttt ctggctttcg agcgtcggga tcatactcat 1167781 tttcatcgct gaggtaagaa tgcgctgtat ggattgcttc ggtgtgccgc caagtgacaa 1167841 tattaattga atttcttctt tgcgaacgcc gacttctgag ttaagccggt ttagaaacaa 1167901 acttgagagc accatcgaat ttccgatgac catcccgctg atcggaatga catatcgtgc 1167961 cgtaagcgga atgatatgaa gagacagcag aattccctgc gtcacaattt ctacgattgc 1168021 taacgcggca aacaccctcc aaaacgaacc gatagtattt ttctttcgct tgatgacatt 1168081 ttgcgccgcc accgcgagca ttaacagcac catcagcagg ataaaaacag ggtggtctcc 1168141 gcgaaaaatc agcgacaaaa cataaccgat gataagcagc tgcaccgcgg cccggatggt 1168201 ggcgatgatc atgtcttttt ctacaccggc tttaaaggat tttgataaaa acaaggcgat 1168261 caaaacaaag atcatcgtta aagagagaga aaggtaatcc attaccgagt gcctcccttc 1168321 aaaaattctt tcgctgcttc atgctgcgga gcggagaaaa atgtgtcggt ttcagcgatt 1168381 tcaagcagcc ggccatctgc cataaaccaa atggtatcgg ctattcgttt tgcctgctcc 1168441 atattatgag tgacccacat gactgtccat tttttctctt gatgctgacg tttgatcagt 1168501 tcttcaatct caagagcaga gaccgggtcc aaggccgatg tgatttcgtc caacaataga 1168561 atggaggaag gatttgagag cgttctggcc agtgacagtc tttgccgctg cccgcccgat 1168621 aagtctctgg cgcttctgtc taacaactct ggcggcagcc ctgcaagcga agccagcttt 1168681 tcaggagagt acagctggga ttgatgcagc ctttgtacaa gacttaaatt gtcacgcact 1168741 gtcccgtcga gcacgggagc cgattgaaac gcgagggctg ccgttcgcct cagctcattg 1168801 acattccatt ctctgacttc ctttccgtat atgttgactt cgccgctgtc aggcgttctc 1168861 attaaattac acatagaaag gagggtgctt ttgcctgagc cggaagggcc taaaacggct 1168921 acgattgcac cctgttgaat gtctccggtg acatcctgca gcacatcata ggtttgtcca 1168981 tcttgtttat agctttttct gactgatctg aaggagatgg ctggtatgtt ttgtgtttga 1169041 tcgtttgctt ccattacaat aatcaccttt caatataagt aggctgacat tatatttaac 1169101 tataacgtga aacagattcc ttttggtagc acaaataaag gagaacaggc tttcacccat 1169161 tctcctgcag atgctacgca gtcagatttg actgtgcttt ctttttcggt tttctcggct 1169221 gtgaagcgaa ggtatgtaac atcatccccg ctattataat gaacaaaccg gcaaatgata 1169281 atagagatgg gaaaacgcct gacagcagaa caatttcacc aagcagcgcg aaaatcactt 1169341 caccggattg agtggcttca acagctgcga gtttttgcgg attgtctctt accatatcag 1169401 tggcccagaa aaataaaacc gtcgcaatga tgcctgagct gacggcaacg ataaaggatt 1169461 gaacggtttg acttgctgtt ggaaggccat ctgaccacca gccgtaagct gctaatataa 1169521 gccagaatgg aaggcttgcc aatgtcattc caagcacgcg ctgaaatgta tcaagccggc 1169581 ctccgtattc ttcgagcatt cttcggtttc ctaacggata ggcaaaagcc gcaatgacaa 1169641 ccggcagcac actgaaaagc agcatcctcc cagaaagcga ttctgcatgc tgaagctgaa 1169701 tcagagccgc tccaatcagg atgatcacag aagtgccaag tgaaaccagg ggaatctttt 1169761 ggcgaatgag ctgcggaccg cccggcatat cttgtttgac ataaaacaaa ggagataaga 1169821 gcaccccggc tacaattgta atttgccagg ttccagctat gagccacccc ggaccgtatg 1169881 cagccgcaaa tgtaatcggt gcgtaaaaaa gcacgaaacc gacgaagctc catttgatcc 1169941 aataaaacgg ctttttcctc atttctagta agagaggcgt gaatgtccct ctcatgatga 1170001 caatcaaaca taaaaatggc accataaaaa taaagcgcag cgaagagctc caaagccagc 1170061 tgcctcctga taactccatc gctctgttta atataaaggt aacggcgaaa aagagtgaag 1170121 ccaatattcc gataacgata gctttcatga tatccctcat tctggcatta tttttttata 1170181 ctatactatt cggtatcatg cagatcaatg gaatcatgag aaaaacatca tgtttggcga 1170241 accgctatat gtggaagaca aaaaagggag gtgaaattga tggaaagaga gacacagaca 1170301 tacttctttc cggatgacgg caggattccg aatcaccctg attttccgct cgtggtgtat 1170361 caaaacgcgc ttaaggacac cggactggca gagcggatcg tcacccggca tggctggtca 1170421 aacagctggt cagggagtgt ttttccatac catcattatc acagcaatac gcatgaagtc 1170481 ctgattgccc ttaggagaga ggctgtgatt cagtttgggg gagaaaaagg ggctgccatc 1170541 cctttcaaat caggcgacgc agtcgtgatt ccagccggag tcggacataa aaagctcagc 1170601 tcaagccccg attttactgt ccttggcgcc tatcccggtg gcgttcagta cgatatgaag 1170661 acggggaagc cgaatgagcg ggaggaagcg gtcaaacaga ttaagcaggc ggcgttgccg 1170721 gcgaatgatc cgatcacagg aaaaagagag cctctattgg aaatatgggt aaagtgaagg 1170781 ggagaaattg ctggattgtc aataactagt gccgcagaaa cgatatgaca tgagctccat 1170841 ataaattaat ttcataatcg aagcaattca cgttcaaatt ttgttcaaaa agtgttatca 1170901 tatagaaggt aatcgaattg gagttttttg tgtttgctat tttcagagag agtaaaggat 1170961 tttgacttat tcaattgttt atttttagat aaaaataata ctgaatatgg caagatgaaa 1171021 aactgggtag taaacattta tttttgtaaa tgattgtgca tgaattcaca atccttattc 1171081 ttatgcctta aaagcgtgag acagggagag gcactaccct ttccaaaaaa atcagcaaac 1171141 tgcttatagt aaaggagaat tggatatgcc agaaacaatc gatcaaacaa atgcgtctgt 1171201 cagccaaagc cagcaagatc ttattgatca gctattaaag ccagaagttc aagaatcatt 1171261 gactgtttta gttgaccagc ttccgaagct gactgagtta gtgaatattt taacgaagtc 1171321 ttatgatttc gctcagtctg tagcgactga cgaagtgtta aagagcgaca cagtcggtgc 1171381 gatcactgaa attctcgagc ctgtaaaaga aacagcgaaa gaagtagctg cgactgcgat 1171441 cgaagcaaaa gaccgcgcgg aagcaagcaa cgaaacaatt ggacttttcg gccttcttcg 1171501 catgctgaaa gatcctcaag ctcaaaagct gttccgtttt gctaacagct accttgaagt 1171561 catgaacgaa cgcgaaaacc aaaaataatc tcagattcaa attgatataa aggacggagg 1171621 atatacgatg tcaaaacata ttgtcattct aggcgctggt tatggcggag ttctttctgc 1171681 tctaacagtt cgcaaacatt acacaaaaga acaagcacgc gtgacagtgg taaacaaata 1171741 cccaactcac caaatcatta cggaattaca ccgccttgct gcaggcaacg tgtctgaaaa 1171801 agcggttgca atgccattag aaaaactttt caaaggcaaa gacattgatc ttaaaattgc 1171861 ggaagtaagc tctttctctg ttgataaaaa agaagttgcg cttgctgacg gttctacatt 1171921 aacttacgat gcgcttgttg taggtcttgg ttctgtaacg gcttacttcg gcatcccagg 1171981 tcttgaagaa aacagcatgg tattgaaatc tgctgccgat gcgaacaaag tcttccaaca 1172041 tgttgaagat cgtgtgcgcg agtactctaa aacgaaaaac gaagcagatg caacaatcct 1172101 tatcggcgga ggcggcttaa caggtgttga gcttgttggt gagcttgctg acatcatgcc 1172161 gaaccttgcg aaaaaatacg gcgtagacca taaagaaatc aaattgaaac ttgttgaagc 1172221 aggtccgaag atccttcctg ttcttccgga tgatcttatc gagcgtgcga ctgcaagcct 1172281 tgaaaaacgc ggcgttgagt tcttaacagg tcttcctgtt acaaatgtag aaggaaacgt 1172341 aatcgatctg aaagacggat ctaaagttgt tgccaacaca tttgtttgga ctggcggcgt 1172401 acaaggtaac ccattagtcg gtgaatcagg cctagaagtg aaccgcggac gcgcgactgt 1172461 aaatgacttc ctgcaatcta catctcatga agatgtattc gttgctggag acagcgcagt 1172521 ttacttcggt ccagacggcc gtccataccc gccaactgca caaatcgcat ggcaaatggg 1172581 tgagctgatc ggttacaacc tattcgctta cctagaaggc aaaacgcttg aaacattcaa 1172641 gccagtaaac tctggtacac ttgcaagcct tggacgcaaa gacgcggttg ccatcattgg 1172701 tgctaattct acaccgctta aaggtcttcc tgcttccttg atgaaagaag caagtaatgt 1172761 acgatatttg acacatatta aaggactttt cagcctggct tactaatcct tttaatgaat 1172821 ctggcattgc caaaagcatt cctttccgag tgctttctgg caatgtcttt ttttatgttt 1172881 atgacagcgt taacatttca ttttcaaaaa agagattgat cccaaaggaa tataaaggta 1172941 aaataaaaac aaatcaaaat gttaacgtta acattttgaa atagaatgaa agacggtgag 1173001 gacatggaac ccttcatggg caaaaacttt ttattgaaaa atgaaaccgc tgtcagcctc 1173061 tatcacaatt atgcgaaaga catgccaatt attgattacc actgccactt aagtccgaaa 1173121 gaaatctatg aaaataagac atttcaaaac atcacggaag cctggctgta tggtgaccat 1173181 tataaatggc gcatcatgag agccaatgga attgaggaga catacattac cggagatgcg 1173241 cctgatgagg agaaatttat ggcttgggcg aaaaccgtgc cgatggcgat tggcaacccg 1173301 ctctacaact ggactcactt agaattgcag cgtttttttg gcatttacga gattttaaac 1173361 gagaagtccg ggtcggctat atggaaacag acaaataaac tgctcaaagg ggaaggcttc 1173421 ggggcaaggg atttaatcgt gaaatcaaat gtaaaggtcg tgtgcaccac agatgaccct 1173481 gttgattctc ttgaatacca tttattgtta aaagaagaca aagactttcc tgtcagtgtg 1173541 ctgcctggat ttcggccgga taaaggactt gagatcaatc gtgaaggctt tcctgagtgg 1173601 gtgcaggcgc ttgaagatgc cgctgccata tcgattacaa cctatgatga gtttttaaag 1173661 gcgttggaaa aacgagtgcg attcttccac tcagccggcg gcagagtttc tgatcacgcg 1173721 atagatacaa tggtatttgc cgaaacaaca aaagaagaag ctggacggat tttttctgac 1173781 agattacaag gaacagaggt ttcttgtgaa gatgagaaga aatttaagac atatacgctt 1173841 cagtttcttt gcggtttgta tgcggagctc gattgggcga tgcagtttca tatcaacgct 1173901 ttaagaaaca cgaatacaaa aatgatgaaa aggctcggac ctgatacagg gtatgattca 1173961 atgaacgatg aagaaattgc taagccttta tacaagctgc tgaactcagt tgagatgaag 1174021 aaccagctgc cgaaaacgat tttatattca ctgaatccaa atgataacta tgtcatcgcc 1174081 agcatgatca acagttttca ggacggtatt accccgggaa aaatacaatt cggcacagcc 1174141 tggtggttta acgatactaa agacggaatg ctcgaccaaa tgaaagcgtt atcaaatgtt 1174201 ggccttttca gccgttttat cggcatgctc accgattcca gaagctttct ttcgtatacg 1174261 cgccacgaat atttcaggcg gatcgtctgc aatttgattg gagaatgggt ggaaaacggc 1174321 gaagtgccgc gcgatatgga gcttctggga agcatcgttc aggggatttg ctatgacaat 1174381 gcgaaacact actttcaatt tcaagaagag aaagcaaacg tgtaacaaag tgtccgctca 1174441 gtatcgctga gcggatcact atccgaaaat tcttaagaca cagaggtgga acatgcgaac 1174501 tgaactggca aataaggttg tgtcggtcga aacggaaaaa aggctttcat tgaaagagaa 1174561 aatgtcctat ggctttggtg attttggcaa cggttttatg tttgatctcg gccagattta 1174621 tttattgaag tatttcactg atgtagcggg aatccccgct gcgatggccg gcggcatttt 1174681 tttagtcagt aagctgtttg cagcgataac agatccaatt gtcggctcat caatcgatta 1174741 tcgcaaaaac atcggcaaac gggggaaatt caggccttat ctattaatcg gcagcatcgt 1174801 gcttgcggtg cttactgttc ttatttttct gtctcccaat gtatcaacga ccggaaaact 1174861 gatatatgca tatgcatcct atatgatttg gggcatcggc tattcgtttg tgaatattcc 1174921 gtacggctca ttaggggcag cgatgactca aaattctgag gaccggacct ccatttcgac 1174981 gttccgccaa atcggatcac ttggcgcctt gtttatcaca agtgtggccg tgatgccgct 1175041 gctcgtcaag tttgataatc cgaaggtcgg ctacccggtg gtcatgggct tgttcgccgc 1175101 gctcggtgtg ttttggtttt atatttgcta ccgcaactgc aaagagcgca ttatcatatc 1175161 ggaagcaccc aaagaaaaat taacactctc atctgtcgtc aaaacattta ttacaaataa 1175221 accgctgtta acccttgtcc tgatgacgat tttttcaatt tccgcataca acattaaatc 1175281 cgccatgctc gtctatttcg cacaatataa cttgggcaat gttgaattaa tggcttatat 1175341 gaacttcatc attattggtt cttccttttt gggcgtcgta ttccttccaa agctcgtcaa 1175401 gatgtttgga aagaaacgaa cggcaatgat cggctttggc atcagtgtgg ccgcggatct 1175461 gatcaacttt atgcttccat ctaacgttta tgtgtttaca attctcgcca gtatcgcctt 1175521 tatcggaatc agtatcccaa atggcatcac gtgggctctt gtctccgata ttatcgacta 1175581 tggcgaatgg aaatccggtg aacggaagga agcaacgaca tattcacttt tcaatttctc 1175641 aagaaagctt gctcaatctt tgtctggctt tctctcgggg atcggtttgg ggattatcgg 1175701 ctatgtgccg aatgcagtcc agacagcaca ggcgctgatt ggcatcaaag cgctgcttct 1175761 tctgtatccg gccattgctt tggcattagc gatgttcatt atcggctttc tttataaact 1175821 cacagaccag cagcatgctc agatcgttca ggatcttcat caaaagagct gacaatataa 1175881 tataaagaat atttaaaata atttgtaaat aaaatgtgtt tgtaggggtt tcgcttggag 1175941 agtgcccaaa aaactgaaaa ggaaggaggc acttgcttga aaacgataac aattgcagct 1176001 gaagaagcaa aggaactcgt ttggcaaaag ctggacggtg ccggtttgaa tgaacgagat 1176061 gctgaaaaag tggcagatgt tctcgtgcac gctgatttgc gcaatgtaca ttcgcatggc 1176121 gtgctgcaca cagaacacta tgtgaacagg cttttagcgg gagggatcaa tcctggggca 1176181 cagcctgttt ttaaagagac ggggcctgtg accggggtgc ttgacggaga cgatggtttc 1176241 ggtcatgtga attgcgacat ggcgatggac catgcaattg acatggcgaa gaaaaaagga 1176301 gtcggcatgg tcacggccgt aaacagcagc cattgcggag cgctaagcta ttttgtgcaa 1176361 aaagcggctg acgaaaagct gatcggaatg gcaatgacgc atacagacag tatcgttgtc 1176421 ccatttgggg ggaggactcc tattttaggg acaaatccga ttgcttacgg agttccggct 1176481 aagcataaaa aaccgtttat cctagatatg gcgacatcca aagtggcttt tgggaagatt 1176541 ctgcaggccc gtgaagaggg caaagaaatt cctgaaggat ggggagtcga tgaaaacgga 1176601 gaagcagtaa ctgatcctga caaggtcgtc tcactttcaa cattcggggg cccgaaaggc 1176661 tatggactat cgattgtagt ggatgtgttt tccggattgc tggcgggcgc ggcttttggc 1176721 cctcatattg ccaaaatgta caacggcctt gatcaaaaaa gaaagctggg gcattacgtt 1176781 tgcgcgatca atccatcctt ttttactgac tgggatacgt ttttagagca gatggatgcc 1176841 atgattgatg aactgcagca atcaccgccg gctgttggat tcgaaagagt gtatgtgccc 1176901 ggcgagatcg agcagctgca tgaagaaaga aataagaaaa acggaatttc tatcgcccgg 1176961 agcgtgtatg aattcttaaa aagcaggtga gtaaaatgaa agcggttcaa gtgcgaaaag 1177021 cgtatgatct ggtgacagcg gaggtgaaga agccagttct ttcaaaggat gatgaagtgc 1177081 tcgtgaaagt caagcgagtc ggcatttgcg gttcagacat gcacatttat catggaacga 1177141 atccgctcgc taccctcccg agagtcatcg gacacgaggt aacgggacaa gtggaggcag 1177201 ttggtgcgaa tgtacagagc ctaaaacccg gtgatcatgt ggtgattgag ccgatttctt 1177261 attgcggatc gtgctatgcc tgccgcaaag ggcggccgaa tgtttgcgcc aagctttctg 1177321 tatttggcgt acatgaggac ggaggcatgc gggaatatat tgtgcttccg gaaagacagc 1177381 ttcacgcggt ctcaaaggac ttgccttggg aggaagcagt catggccgag ccttatacga 1177441 taggcgccca ggcagtgtgg agaggccagg tggaaaaagg tgataccgtc ctgatccagg 1177501 gagcggggcc catcgggatc tgtgtgttaa aaatggcaaa actggcgggc gctgctgtca 1177561 tgatgactga cttgaacaac gagcggctgg catttgcgaa agaaaacggc gccgatgctg 1177621 ttgtaaatgt ccaagcagaa catgttgccg agcgggtcct tgaatggact gggaatgaag 1177681 gagcaaacgt ggtcattgat gctgtttgcc tgccggagac ttttgcactt tcaattgagg 1177741 ctgtgtcacc ggcgggacat gtggttgtgc ttggatttga tgaaagagcg gctcagattt 1177801 ctcagctgcc aattacaaaa aaagaagtca cgataaccgg atcccgattg cagaccaatc 1177861 agtttccaaa agtggtagag cttttgaatg gaggccggtt aatgcataac gggctggtga 1177921 cccatacatt ttcagttgat gacgttcatc atgcatttca gtttattaag gagcatccag 1177981 atcaggtgcg gaaagccgtc atcacgtttg attaaatgac tgaatccgga ggtgcgagca 1178041 tgaatatgac attccgatgg tatggacgag gcaacgatac agtcacactt gaatacgtga 1178101 agcaaattcc cggtgtcaaa ggcatcgttt gggctctcca tcaaaagccc gtcggcgacg 1178161 tgtgggaaaa agaagaaatc agagccgaaa ctgaatatat tcaatcctat ggttttcatg 1178221 ctgaagttgt agaaagcgtg aatgttcacg aagcgattaa acttgggaac gaagaacgcg 1178281 gccggtatat tgaaaactac aagcaaacga tccgcaacct tgccggattt ggcgtgaaag 1178341 tgatctgcta taattttatg ccggtttttg attggacacg cacggacatg ttccggccgc 1178401 tagaagatgg atcgaccgct ctgttttttg aaaaggccaa ggtggaaagc cttgatcctc 1178461 aagagctgat tcggacggtg gaggaagcat ccgacatgac actgccgggg tgggagcccg 1178521 aaaaattggc tcggatcaaa gagctttttg ctgcctacag aacggtcgat gaagaaaagc 1178581 tatgggacaa tttatcattc tttttgcagg aaattcttcc tgttgctgag gcctatggtg 1178641 ttcaaatggc cattcatccg gatgacccgc cgtggccgat tttcggactg ccgcgcatta 1178701 tcacaggaga ggcaagctat aagaaactgc gggcgatatc agattcaccg tctaattgta 1178761 tcaccctttg tacaggttca atgggagcca atcccgctaa cgacatggtg gagatcgcta 1178821 aaacgtatgc cggcatcgct ccattttcac atattcgcaa tgtgaaaatt tatgagaatg 1178881 gcgattttat tgaaacatct catttaacaa aggatggttc gatcaacatt caaggcgtga 1178941 tggaagaact gcataagcag gattacgaag gatatgtcag accggatcat gggcgccatc 1179001 tttggggcga gcaatgccgc ccgggatatg gcttatacga tcgggcactt ggcatcatgt 1179061 atttgaacgg gctgtgggac gcttatgaag caatggcaaa aaaagaggtg ggcatatgat 1179121 cccgctgcat gagaacctgg ctggtaaaac ggctgtcatc actggcggca gcggcgtgct 1179181 ttgctctgcg atggcccggg agctagcccg tcatggcatg aaggtggcga ttttgaatcg 1179241 gacggctgaa aaaggccaag cggtcgtgaa ggagataacg gcggctggcg gcacagcgtg 1179301 cgctgttgct gcggatgtgc tggacaggat gtcactggag cgggcaaagg aagacatcct 1179361 tggccaattt ggcgctgttg atctgttaat taacggggct ggcggcaatc atcctgacgc 1179421 gataaccgat gtggagacat atgaagaagc gggagaaggc caatcctttt ttgatatgga 1179481 tgagaggggc tttctaactg tattctccac caacttcacc ggtgcgtttc tggcctcgca 1179541 agtgtttggt aaagaactgc tgaaggcgga ttcacccgcg atcatcaacc tttcttccat 1179601 gagtgcttat tcacctatga cgaaggttcc ggcatacagt gctgcgaaag catccatcaa 1179661 taattttacg atgtggatgg ctgttcattt tgccgaaacc gggctgcggg tcaatgcgat 1179721 tgccccaggc ttctttctga caaaacaaaa tcatgatctg ctgatcaacc aagacggaac 1179781 gttcaccagc cgatctcaca aaattattgc gggaacaccg atgaagcgct tcggaaaacc 1179841 ggaggatttg ctcggtacgc tcctttggct ggcggatgaa tcctattccg gttttgtcac 1179901 tgggatcacc gttcctgtcg atggaggatt tatggcttat tcaggtgtgt aacgaaagcg 1179961 gtgcaacaga aactgaacca acataggggt gaggttgaga tgttttcaaa agataagctt 1180021 cccgttatcc tttttttgtt cctggcaggg gtgattaatt acctggatcg ctcggcgctt 1180081 tccattgcag ctccttttat tcaggatgat ctcacattgt ctgccacaca aatgggcttg 1180141 attttcagca gtttttcgat aggttatgcc atttttaatt ttcttggggg cgtggcatcc 1180201 gaccgctatg gggcaaagct gaccttgttt gtcgcgatgg ttgtttggtc gctgtttagc 1180261 ggagcagtcg ccctcgcttt tggctttgtc agcctgctga ttatacgcat tctcttcgga 1180321 atgggagaag gcccgctttc ggcgaccatc aacaagatgg tgaacaactg gttcccgccg 1180381 acccagcggg cgtccgttat cggtgtaacc aacagcggca cgcccctcgg gggagccatt 1180441 tccggcccga tagtcggcat gatcgcagtg gcgttcagct ggaaggtatc cttcgttctc 1180501 attatgatta ttggattgat atgggcagtg ctctggttca agtttgtcaa agaaaagccg 1180561 caagagacga tcaaggaagc accggcaata aaagcagaaa cgtctcccgg agaaaaaatt 1180621 ccgctcacct tttacctgaa gcaaaaaaca gtcctgttca cggcgttcgc ttttttcgct 1180681 tacaactaca tcctcttctt ctttttgaca tggtttccga gctatcttgt cgacgagcgg 1180741 ggattaagtg ttgaatcgat gagtgtcatc acggtcatac cgtggatttt aggatttatc 1180801 gggctggctg cggggggatt tgtttctgac tatgtgtaca aaaaaacggc ccgaaaaggt 1180861 gtgctgttct cgcgcaaggt tgtgcttgtc acgtgtttgt tttcatcagc tgtcctgatt 1180921 ggttttgccg ggcttgtggc aacgactgcg ggggctgtca ctcttgtcgc tctgtcagtg 1180981 ttctttcttt atttgaccgg tgctatctat tgggctgtca ttcaagatgt ggttgatcaa 1181041 aacaatgtcg gttctgttgg cggcttcatg catttcctcg ccaacacggc aggaattatc 1181101 ggcccggctt taaccggatt tattgttgac caaacaggca cgttttctgg agcatttttg 1181161 cttgccggtg ggctggctgt cttcgcttca cttgctgtga ttcgttttgt ccgtccaatc 1181221 attggtaagc cagcgggaac agaagctgag aatcctgtgt cttattaatc tggaaatata 1181281 gtgggagagg cggtatgttt gatgatacaa tatacagtaa ataatcgcag ccggtatgat 1181341 aaggaaggga attagatggt aaccataaaa gatatcgcaa aactcgcaaa cgtatcccac 1181401 actactgttt ccagagcact caacaacagc ccttacatca aagaacatac gaagaaaaaa 1181461 atattagagc tagcagagca gctcaactat acaccaaatg taaatgcgaa aagtctggcg 1181521 atgcaaaagt cgcatacgat cgggctattc tttacaagca ttacaaacgg aacctcacac 1181581 agcttctttg cagacactat caaaggcgtc aatcaagcca taagtgagga ttacaatctg 1181641 tatgtgcgcg gcattgatga tctgaaaaac tatgactccg ttacaccgat gagatatgac 1181701 ggcatcattt taatgagcca aagtgacatt gataattctt ttatttacca tattcgcgaa 1181761 aaaaacattc cgcttgtcgt gctgaatcgt gatattgatg atcgtaccat cacgaatatt 1181821 ttgtccaatg acaaggaagg ctctcaagaa gctgtagaat acttcattca gtccggacat 1181881 caagacatcg ccatcatcga ggggatcgaa ggctttaaat cctcccagca gcgaaaggaa 1181941 gggtacttat ccgcactgat tcaacatcat attccgatca agcatgaata cagtgtcaaa 1182001 ggacagtacg atatggaaag cggctttcaa gcgatggagc ggctgctggc actgccgaat 1182061 cctccaaccg ctgttttttg ttcgaatgat gacatggcaa tcggagcgat gaatgcgata 1182121 ttcgcaaagg gcctgcgcgt tcctgatgat atttcggtga tcgggtttga tgatattggg 1182181 ttttcacagt acatcacgcc aaggctttca acagtaaagc gcccagtgga gaaaataagc 1182241 gtgctcggtg cgcaaaaact cttgtcgctg atcagcgagc ccgaaacaaa agcagaaaaa 1182301 atcttggaaa acacagaatt tatggtgcgt gattcagtca gacgattgac gacgtgatgt 1182361 cccgtttttc agcgggcatt ctttatacag aaaaatgtta acgtgtgcat aaagtgagag 1182421 ggaggcaata agggtgcaga agctgaataa aaatgtgtac gatcactata ctcagtatcc 1182481 agaaaaaatt ctccaattcg gagaaggaaa ctttcttcgg ggatttatcg attggcagat 1182541 tgatcaattg aatcaacaca ctgattttaa tgggagcgtg gcagttgtcc agccaagagg 1182601 ctcagaaaaa atcaaacgat taaatgagca agatggatta tatacacttt ttttacaagg 1182661 aatgaaagac ggagaagcgg taaacgagca tatgattatc aactcaatca gccggggaat 1182721 tgacctgttt tctgattatg aagcatacaa agaattggca tcaagcgaaa ggcttcggtt 1182781 tattatctcc aacaccactg aggctgggat tgtatgtgat gaaaaagatc gtttagagga 1182841 taggccgcaa aaaacattcc ctgggaaatt aactgcattt ctttactttc gctatcaggc 1182901 ttttaaagga gatcagacaa aagggtgtgt cctgatccca tgtgaactga tcgagaataa 1182961 cggtgaaaag ctgagggaaa cggttcttca ttatgcacat ctgtggaagc tggaggaagg 1183021 atttacacag tggattcatg aggccaatac attttgtaat agtttagtag accggattgt 1183081 tccgggtttt cccgtcgaca gcattgatga gatcacggca gatcttggct atcaggatga 1183141 tttgatagtt gtgggagagc aatattattt gtgggttatc gaggggcctg attggattgg 1183201 aaaagaactt ccctttgcgg ctgcagggct gcatacaaag atcgtcagcg acctcacccc 1183261 ataccggact aaaaaagtaa gaattttaaa tggcgctcat acagcaatga cgccagtggc 1183321 tttattatac ggcttgaaga ctgttaggga tgcagtcgag catccggaag tggggcgatt 1183381 tataagagag ctgattgatg acgaaattct tcctgtttta aaaatggaag gtctttctca 1183441 gtatgctgac gatgtgctga accgttttaa aaacccgtat attaagcatt acctggaaag 1183501 cattgcattg aacgccattt ccaaattcaa aacgagaaac ctgccgactc ttaaggaata 1183561 tgctgaacaa aagggacagc ttcctgaacg cttggtgttt tctttcagcg ctcttctgta 1183621 tttttatcat gataacgaga cattgcagga tgatccggca gttcttcaat ttttcaaaga 1183681 ggtttggtgt caggaggatg gcgacatgct tcggattgca tcaagagtgt taggcgaaca 1183741 gcggctgtgg ggggcagatc tcaatgagat accgaagctg actgatagag tcgctgttta 1183801 cttgaatcat attcatgagc tgggcatgca gagggctctt gaacaatact gcatacaagg 1183861 gggagaggta cgttgaagtc gtttataaag attcataagc aagataatgt ccttcttgct 1183921 ctgcgggata ttcaaaaggg agagaggctg catgcttacg gcgtgtcgat tgaagtaaag 1183981 gatgatataa aaagaggcca taagattgca ttgcagtcta tcaaagaaaa cgacagcatc 1184041 gtcaagtacg ggtttccaat cggtcatgca tcacaagata tctcgatcgg agagcatatt 1184101 catgtccata atacgaaaac aaacctgtct gatatccaat tatacagcta tacaccgaga 1184161 tttgatgaaa atccgtattc taatgagaac cggacgttta aaggttttag aagagaaaac 1184221 ggagatgcgg gtgtacggaa tgaattgtgg attgtcccaa ctgtcggctg tgtcaatgga 1184281 atagcagaaa aaatgctgca gcgttttgtc agagaaacag gggatatcgc tccatttgat 1184341 aacgtactgg tgttaaagca tcaatacgga tgctcgcagc ttggcgacga tcatgaaaat 1184401 acgaagcaga tcctgctgaa tgccattcgc catccaaatg ccggcggcgt cttggtgtta 1184461 gggcttggct gtgaaaacaa tgagctggca agaatgaagg aagcactgca agatgtgaac 1184521 ttgaagcggg tgaagtttct ggaatcccag tcggtgaccg acgaaatgga ggcaggcgtt 1184581 gctttgctga aggaaattca tgaagcggcc aaaggagata agagagaaga cattccgctg 1184641 tctgaactga agatcgggct gaaatgcgga ggttcggacg gtttttccgg cataaccgca 1184701 aacccgctgc ttggacgttt ttcagattat ctcattgcac agggagggag tactgtgctg 1184761 acggaagtac cggaaatgtt cggcgcagaa accatcctga tgcagcgggc tgccaatgaa 1184821 gaagtgtttc ataagatagt cgatttaatc aatgatttca aacaatactt tattaaacat 1184881 gatcagccgg tgtacgaaaa tccttcaccg ggcaacaaag cgggcggcat ttctacactt 1184941 gaggataaat cgctgggctg tacgcaaaaa gcggggattt ctcctgtcac ggatgtcttg 1185001 aaatacggtg aagtactcaa gacaaaaggg ctgactcttt tgagcgcacc gggcaatgat 1185061 ttgatcgcct cctccgcatt ggcggctgcc ggctgccaaa ttgtcctctt tacaacggga 1185121 agaggcacgc cgtttggcac ctttgtcccg acggtgaaag tagcgacaaa caccgagctg 1185181 tatgaggcga agccgcattg gattgatttt aacgcaggcc ttttagcaga ggatgatgtt 1185241 catgaggaat atgtgctgcg tgagtttatc cactatatga ttgaggtggc aagcggccag 1185301 cttgtgaacc atgaaaaaaa tgatttcaaa gaactcgcca tttttaaatc gggtgtgacg 1185361 ttataataag aaaaggctat ccttcaagcg gatagccttc ttcattaaat caattttaaa 1185421 ccgctgacta aaataatgga agccataata aattgcagtg gacgcgggga gaatcgaggc 1185481 gaaagatggc tcccgatcag tacgccggga attgaaccga ggagcagatt agctgccagc 1185541 atgtaatcca cgcttccgaa gcttgcgttc aaaatgcctg ctgccgtaac aagaagaaaa 1185601 gcatgcgcga tatcggttcc gacaatctgt gacgctttca tgttaaataa gtaaatcatg 1185661 gcgattgcaa ataatgagcc ggacccgatt gatgttaatc cgacgataaa cccaaacaca 1185721 acaccaataa gaattgtcag cgccctctta ttttcaagcg gcatcagctg ccagcggttg 1185781 gggcgaagtt ttctatccaa aaacaaacga acgatgattg aaatggcaac cagcgttaac 1185841 acatatccta gagcgtgctt aataatttct tcctgatgct ggtgaaaggc ggggaacaaa 1185901 tgcaatatgc caatggctag cgaagcactc ggaataccgc cgatggctaa gtattttacc 1185961 aatttaaagt taatcgtttt ctgccgccaa tgggaggcaa cgccaaacag ctttgtgatc 1186021 gagttatata caagatccgt accgaccgcg atggaaggat taattccaag cacaattaaa 1186081 aggggagtta ataaggccgc tccacccact cccgtcaatc cgactaaggc tccgacaaac 1186141 aaacccatca atatgatgct tacactcatg ataaaggcct cctgaaaacc cgactagaat 1186201 tcacccgaat cttattcgcg ttggtcaagt attaattgta agtgctccat cggctgctga 1186261 aaaacccgag ctctatccgc tccctgatgg tatcattcaa ttgacaacac cttatacatc 1186321 aggagaacac gtctttcagg tgcaacgagc acttgcggct ctgtattttt accctgataa 1186381 aggcgctgtt aacaacggaa ttgacggcgt ttacggaccg aaaacagctg acgcagttgc 1186441 ccgttttcag tctgttaacg gtctaactgc tgacggtatc tacgggcctg cgacgaaaga 1186501 gaagatcgca gcgcaattaa gctgatcaaa gaccataaaa atcccggagc cgctccggga 1186561 tttatttttt cttcttcaac ttttttataa ttccagcact gcgctccctc acccgaagcg 1186621 agtacccgga aagcccaaac cttccgtaat caacaaactt cacacgcctc accaattttt 1186681 tcactgtatc acctgacatt atcctctgtt tgtatttatt atatgtcacc ctttaagaaa 1186741 aggaataagg acaagagctg ttttcccttg tccttttagt gtgatcatgc tttttttcgt 1186801 ttatactcgt caatcagccg ttcgttttct ttgaagattc ttgctgtatg cggactgact 1186861 tgatagcttg cgacactggt ggttgaacgt tttttcagga ttttaaacgg cttcgccgct 1186921 ctgggctcgc atctgttttg aaacgcacgt tccattatcc ttcaccttcc tcctcaattg 1186981 gcagcaccaa atcatatatg ctcgttaatg acgtaaatag caaataatca aattccgtga 1187041 caatgctgtc agacgtcagc ttgatgacat agttctgtgt ctcgatggta aaagggatga 1187101 gaaccacttt tccgtattgg tcgtaataaa catcctttcg atcgagccgt gtttgtacat 1187161 ctgccggatc atccatatgc tcggttaacc ggtctttatc agcctgtgtc gaatagtggc 1187221 aaagagaagc cgttaagttc attttatcag cataggtttt cagcagctta tcaatacctt 1187281 cagcataagc atctatactt ccataataaa catggatcgg ttcgtttttc aataggtatt 1187341 ggtatgtttt cagccgattg agatacatgt ggagcatttc gttgttttct tcaagaattt 1187401 ctcttgtgtc tgtttcaagc tcgctgccgg ccagtttttt gacatatgca cttaagaaga 1187461 taaaagcatc aatcaaagca aaactgactg cgacaatgag ataccgttcc cagtgggtaa 1187521 atagggaagt gggctcatat gtccagtata ccatagcgcc cagaacaaac agcaaatacc 1187581 aagttttccg aatggcggac attttttctt tgaccttcgc ttcgaaacgc cacgtggcat 1187641 acacgtataa ccccagtccg gccacgatgc accagaccat gatctgaaag aataaaacca 1187701 tattcgaatc cctcacatct gaaataggtt ctgcttattg tattcgagag atccggatgg 1187761 ttttcctgtt ccatcaaaaa aaccgctcct ttgacagaag cggtgtgaca ttaaaatatc 1187821 atatttaaaa taaagtaggc gatggcacca agtgtcgctg aaatcggaag cgtgatgacc 1187881 catgtaatga gcattcgctt ggccgtaccc cagtttacgc cttttacgcg gtgggacgca 1187941 ccgacgccaa gaattgatga agaaatgacg tgggttgtac tgaccggcaa atgaataaac 1188001 gtggcgccga aaataatggc tgctccggtt aagtcagcgg aaacaccgtt taccggacgg 1188061 attttcatga tctttccgcc aacggttttg atgattttcc agccgccgat tgatgttccg 1188121 agacccatgg ctgtcgcgca ggcgaattgc acccaggtag gaatatcatt agcagaagta 1188181 tgtaaattcg ctgtgatgag agccattgtg ataattccca ttgctttttg cgcatcgttt 1188241 gttccgtgtg tatacgattg cagggcagct gttacaatct gcactctgcg gaattgctta 1188301 ttcgttttcg ccaagttgct gtctttgaaa atcagcttaa cgatgctata aagaataaaa 1188361 ccaaggacaa aggcaataat tggtgataga atcagtgctt caatgatttt aatgaagccc 1188421 ttatagttta acgctgcaaa tccggctgcc gcaatggctg caccggcaat agcgccgatg 1188481 atggcatggg atgagctgct tgggataccg tagtaccatg tgataaggtt ccaggcaatt 1188541 gcagcgagta gcgcagccaa aatgacaaca gagccatttt ccagcgtata aggatctacg 1188601 atgtctttcg taatggtttt ggcaacacct gtaaacgtca ttgctccgac aaagttcatc 1188661 acagcagcca atataatggc atggcgcggt tttaacgctt ttgttgatac cgaagtcgca 1188721 attgcgtttg ccgtatcatg aaacccgttg atgaaatcaa acgccagagc acaaatgact 1188781 attagtatcg ttaatattaa tagaatatcc atttttaccc ctcgttacgc gtttttcata 1188841 atgatggttt caagattatt ggcaacactt tgacaagagt cggcgatttc ttcaagcgtt 1188901 tcgtatattt cacgatattg aatgactttg attggatctg tttcatttcc gaaaagattc 1188961 tttaatgatt ttctgtgcaa gttgtcacaa ctgtgctcat actctttaat tttgattgcg 1189021 tgaggctgaa tatcctttaa gcgattttct gccagcagct cgatcgtaat caaaatctct 1189081 ttcgcacatt ctctgatata tccgctgaat ttatcaatat gctcgtctga tgaagtaatt 1189141 gagaaaatct ccatcatggc agagaaatgt tcgattccgt caagcacatc atccaagctg 1189201 tttgtcagct gaaggatatc ttcgcgctca ataggagtga tgaacgcttt gttaagctct 1189261 ttaatcatga catgaacatg attgtcacct tttgtttcat attcctttaa cgtatctgca 1189321 aattctttaa gagtcgtttg gttagtgacc ttaaaattca caaaatattc tgcagtttcg 1189381 tctatgttct ttgcaatttc tgttaaaagg agtgagaact tatctttttt tcttcttatc 1189441 attaaaaacc ctccatagtt tgaatgaaca atgcacacat caaattatta tatagccttt 1189501 tgtcgaaaaa aaacaggtaa agtcgaaaaa aacgtatctt gacttttttg ataaatcgtg 1189561 tctccttatt ttgacctact tcgctttaaa aaaacgaccc aagtttgcaa aaactttctg 1189621 cttaacgtaa aaagtatatc aaaagttgtg tttttcctgt caacttttat cttctgtttc 1189681 accaaaaaac ggttccctaa acaagggaac cgttttatca gcttgctttt cgttttttca 1189741 tcccgtaata aacaggcagt ccggcaaggc cgatgaggat ggataatccg cagctcattg 1189801 tatctgtaat gagtgtgctg cctaacacaa agaaggagcc cgcgattgcc agaattggca 1189861 taaatggata aagcggaaca ctgtaggcgc gcttttctcc ctttgctcgc ttgcggagaa 1189921 taaacactgc aaaaaaggcc atcacataaa aaatgtagat catgaaaatg gagatttctg 1189981 agagcttatc agggttgctg atcagcatca taatcaaagc caaagcaatt tgaaaagaaa 1190041 tcgcaatcca tggtgtgcgg aacgacgggt gtacatgtga cagtttttca gcaaatggaa 1190101 gctgtttgcg ttccgccatt gcaaatgaaa cacgcgggaa agaaagcacc tttccattta 1190161 agcacccaaa gatgctgacg ataatcccta cactgatcag ctttccgcca attgaaccga 1190221 acagcatggt tgcagcggtg cttgtcgcat tttcaccaag cgtgacaatt tcgttcgctg 1190281 acaggatgtg aagcaatgca aaattaatga aaatatagat cgccgttaca attaataatc 1190341 cgcccgtcat agcgcgtggc agcagctttt cgggattttt catttctccg ccgagagcgg 1190401 caaggagaat ccatccgtca taagcaaaca acgtagctaa aatagccgcc ccgaagttca 1190461 tatcagaaat gctttcgttt actgctgtga agatgtgctg atcgcctttc caaaggccaa 1190521 agacgatgat gcaggcaatc ggaatcagtt ttccgatcgt tgtcagcgtt tggacaaaac 1190581 cgccgtattt tgtaccgata atattaatga cgcataaaaa gagaactgct ataattccaa 1190641 tgacttttga tagtccagat ccccagccga aaagattcgc cattaaagat ccaaaatata 1190701 aacccagcgc gccaataatc gccgggccgt aaatgataat ctgcacccag ccgcacaaaa 1190761 atccccaaaa ctcgccgtac acttcttcaa ggtacgtata aagcccgccg gtttttggaa 1190821 tctgcgttcc gatttccgcg attgtcaaac cgcccgccag tgttaaaata ccgcctaaca 1190881 gccaggcgaa aagcgccatt tttgaatcac ctgaataagc aagcacagcg ccgggcttca 1190941 taaaaacacc agaaccgata atggttccga tgacaagagt aagggcaaac aagaggccta 1191001 tctctttttt caaaccgttg tcttcagtat gcatgtcctt aacctcctat gatgttgaag 1191061 cttcatgttg aagaatctat tttttcatat tgtaaaccct attttagaaa agtgaaataa 1191121 aataaatttt ctgattttcg aaatttgctt tgtgtacagc agataaaact gtagaaatac 1191181 ctgttttaat ggtctataaa cgaataaaat tcataatttt tatttacaaa gttcgtgttt 1191241 tatgtattag gattttagcc ggtacagagg ggagatgaga attcagaaaa tgaacgaacc 1191301 ttcggtgaag ctgatatgtt gactttctca tgcgaataaa atactttgtt attagaacaa 1191361 taaatataca attatgatat gatatctcga aatcgagata aaataacctg gagggacagc 1191421 atatgaaagt taacggcatt caccacgtat cggcattaac ggccgacgca caaaaaaact 1191481 tggatttcta taagaaagta ttaggattaa agctcgtcaa aaaatccgtc aatcaggatg 1191541 aaccgacaat gtaccatctg ttctacggag atgaagtggc aaacccggga actgagctga 1191601 cgtttttcga gattccccgc attgcaccgt ttcatgcggg aacaaacagt atttcttcta 1191661 ttggattgcg cgttccaggc acagaagccc tgcattactg gaaagaacgt tttgaagagc 1191721 agcaagtaac gcacagcggc atctccaaaa gagccggacg tgacatattg gcatttcaag 1191781 atcatgaggg gcagcgactt gtgctgactg ctgatgagga aggaaaagga tatggcctgc 1191841 ctgttaaaca gagcggcatt ccggaagaat tttcgtttcg cgggttaggg ccggttgaac 1191901 tgactgtgcc atatgctgaa ccaactttac acgtattgac gaatattctt ggatttacag 1191961 aaatcagccg tgaaccagtc gaagggcaag gaaccgccgt tattctggaa tcaggagaag 1192021 gcggtgctgc aacggaaatc catttaatag aaagaaacga tcttccgcga gagcgtcaag 1192081 gcaaagggag tgttcaccac gtcgcatttc gggtaagaga tgaagaagaa cttgccgggt 1192141 ggcaccggat catcagccgc gaaggcttta gcaattcagg catagttgag cgctactatt 1192201 tcaaggcgct gtatttcaga gaaccgaacg gcattttgtt cgagttatca acagacggac 1192261 cgggctttat ggtagatgaa aatcttgatg agcttggcca aacgattgct cttccgccat 1192321 atctagagca tcgaagagca gaaattgaag caaaattgaa accgatccaa taaattgtga 1192381 ttcttttgcc ttccggcgcc gccggagggc tttttttatt accataatta attttgacct 1192441 aaacagcatg ccttattagg gaggaaatat cagatgctga ttgggagaaa tggcttaaaa 1192501 ccctttgcaa atatgggtga ttggtatgga atggcctcgg caaaaatatt gtctttgttt 1192561 attaatagtt tattcatatt tgcttgttac actatttcaa agttagacaa aaaggagtga 1192621 aaaataagtg gaaaagaaaa aacgcgagct ggatatcgtc ctcctcctca ttttgctcgc 1192681 atctgcattc ttaaatatct ataacatttg gaaggacgac acggtgaatc cttattacac 1192741 cgcggcagtt acaagtatga tgcaaagctt tcataatttc ttttatgctt cgttcgatgc 1192801 tgccggcttt ataacagtag ataaaccgcc tgttacatac caaatccaaa cgatcagcgc 1192861 actgatattc ggtatgcacg gctggagcgt catcctgcct caggcacttg ctggtgtagg 1192921 ttctgtcctt cttatgtact tgctgataaa gccgacattt ggaaaaacgg cggcgcgtat 1192981 tgcctcattt gttatggcat gtacgccgat agctgtagct gtagcacgta caaacaatgt 1193041 tgatgcatta ctggtatttt tcttattgct tgctacatgg cttctcttta aagcgatcag 1193101 aaaaggaaag ctgatctggc tgttagcagc atttttcgtt gttggagtag gttttaatac 1193161 aaaaatgctg caggcttaca tgattttacc ggctttctta ttgttctatc tgattgcggc 1193221 aaacgccaca atcaagaaaa aaatcgtttc attggtaagt gcgttagccg tattagcagc 1193281 cgtttcgtta tcgtggccgc tcattgttga caatatccct gcaagcaagc ggccttatat 1193341 cggaagcagc caaaccaact ctgttttgga attggctttc ggctataacg gaatccagcg 1193401 gctgacaggc caaaattcag gcggcggcca gggtgcgcca aacaaagacg cttcaaaaga 1193461 aatgtcttct tctgataaca ctcaagcacc gcctaatcag tcatcaagca acagctcatc 1193521 aagcgatggt aaatcctcaa atggcaatat ggcggcgcct ccatccaatg gccaaatgcc 1193581 aagcggcggt caaggaggcc ctccaagcgg cggagatggc ggccaaggcg gacccggcgg 1193641 agacggaggg aaaggcggta caggaaccgg ttcgaaaatg caatcaggtt cagggatgtt 1193701 tggaacggga acacctggtc cactgcggct tttccaacaa gagttatctg atcaaatcag 1193761 ctggcttctg ccatttgcga tatttggaat cgcaggctta ctgatcgctg gcgcaagaga 1193821 aagaagaaga ttatctgtag agcagaagga aacggtgttc tgggttgcgt ggcttgtacc 1193881 gattgccgga ttcttcagtg tcgcagaatt tttccatcat tattatctca tcatgctggc 1193941 accgccgatt gcggctcttg tcggtgcggg gtgggtcgct cttgttcatc tgtaccgcaa 1194001 tcagacaggc tggaaagcat ggcttttgcc gggagcaatt attgcgacaa ctggatttga 1194061 attgtttatt ctcagaaact acaacgatca aatcggtgtt ggatggagta tcggggtagg 1194121 tgttatcggc gtgttgtcag cgattgcttt gctgctgttt aaacagcgcc aaaaaccgtt 1194181 cagttattat gtttcacttg cagctctcct cgcattgctg gtgatgccga tgtattgggc 1194241 aagtacaccg cttctgtacg gaggcaacag ctcactgcct gaaacaggcc ctcaactcgc 1194301 atcaatgagc ggaaaaggca tgggaatgtc tgatgcgact gtaaatgaaa aactgatcaa 1194361 atatctagag gagaataact ccggagctga atacctattc gccacaaccg attcgaacac 1194421 agcggcacca tatatcatta aaacgaaaaa agctgtcatg gctattggtg gatacagcgg 1194481 ttctgacccg gcaatcacac tgactcaatt caaaaaactt gtaaaagaag gaaaagtgaa 1194541 atacttcttg gcttctggaa tgggaagagg cggaaacaat gacattgttg aatgggttga 1194601 gaaaaatgga aaagaagtag catcagaaaa atggcaatca agttctgatc aaaaaacaga 1194661 aaatactgat tcagctgata catcaagcag caaggcttca ggtgaaaacg gcaaaatggg 1194721 cggacctggc ggaatgaatc agtcagcaac attatacgaa ctacatgctg atgaatagga 1194781 ggcaaaaaca tgagcagaca tattcaatat tcaattgttg tacctgtgta taatgaagag 1194841 cttgtcattc atgaaaccta tcagcgctta aaagaggtca tggatcaaac gaaggaaaac 1194901 tacgagctgc tttttgtcaa cgatggcagc aaagaccgca gtattgagat tttaagagag 1194961 cacagcctga tcgatccgag agtgaaaatt attgattttt caaggaattt tggacatcag 1195021 atcgccatta cggcaggtat ggattatgca caggggaatg caatcgtcgt cattgacgcc 1195081 gatttgcagg accctcctga actgatttta gaaatgattg aaaagtggaa ggaaggctat 1195141 gaagtcgtgt acgccgtacg gactaaacga aaaggggaaa cctttttcaa aaaacaaacc 1195201 gcggctatgt tttaccggct tctcagcggt atgacagata ttgatatccc gattgatacg 1195261 ggggattttc gcctcatgga cagaaaagtc tgtgatgaaa tgaagagatt aaaagaaaaa 1195321 aatccatttg taagagggct agtcagctgg gtgggtttca aacagacagc ggtcgagtat 1195381 gtacgtgatg aaaggctcgc cggagaaaca aagtacccgc tcaagaaaat gctgaagctg 1195441 tcaatggacg gcatcacgac attttcacat aaaccgctga agctggcaag ctatgcgggg 1195501 attttaatgt caggtactgg atttctgtat atgtttatcg tgctgtatct gaagctattc 1195561 acagacagca cgattaccgg ctggtcatca cttattgtga tccagctcct gttcagcggc 1195621 attgtccttc tgattttggg cgtgattggc gaatatatcg gcagaatcta cgatgaagcc 1195681 aaagacaggc cgctttacat cgtccaaaaa tcgtatggaa ttgaaaataa aagactctat 1195741 agagaccagc atatgtcata acctcaaacc ccctgtccgt aatggacagg gggtttttat 1195801 gctctgagca cgatctaaag caaaagatgc tgatagatat atggaaattg ggtaaagaag 1195861 agattgtgag cttgtactgc ggttcagtca tgctgaaata aaaacagcaa aacttaaaga 1195921 tttcgtcctc ggctttgctg catgtcagct gttatattgg ggggctttta agaaacgcat 1195981 gattagagcc gtaccagtta tgtttaatag aatactcgta cccaatacaa ttccccacgt 1196041 caacgtcgat tcagagagaa gaaagctcag caaaagaaaa gccaatcctg cgcagatcat 1196101 acccagtccc acggttttca tgttcatgcc tcctagcaaa cgatgtttct agcatctgat 1196161 gtgaatgatg tcaatctgta tgatatacgg atatctcgtc agaaagtttc atagaacaat 1196221 taggtctttt atctaataaa aagcctcaga ccgcttttac ggcctgaggc attatgtctt 1196281 acgaagtttt ctcttctttt tgatccagtt taattttttt cgtcatttct ttgccgtttc 1196341 ggagaatttt cacttcaacg gtatcaccga tctttgcgtc tttatataag atattgcgca 1196401 attcactgcc tgtatcaatt tctttacctt ttaggccgat gataatatcc tccgctttta 1196461 atccggcctt ttcagcagga gagcctgaag cgacctcacg gatgtaaacg cctttattca 1196521 gctggctgcc gaacaggccg agtgtgcctt cttggtaatt ttgcggcact tgctctagat 1196581 caagcatgct gacaccgata tatggacgtt caatttgtcc tttagacagc aattcttcag 1196641 caatcggttt tacgtcattg cttggaatgg cgaatccgat accctcaaca tcatcctcac 1196701 tgattttcat actgttaatg ccgacaattt tgccgtctgt atttaacaaa ggaccgccgc 1196761 tgttacctgg attaattgct gcgtctgtct gaatgacgtt aatgctcgtt tcgccggctg 1196821 atgtagacat tgaaaccgtt ctgtccacgc cgcttacaat tccttgtgtt actgtgcggg 1196881 acaggtcttt tccaagcgga tccccaatcg caataacggt ctcgcctgtt ctaagatcag 1196941 atgaatcacc gaagtttgcc acttttgtga cgtggtcatc actgatttgg aggacggcta 1197001 aatcagttaa cgagtcactg cctaccagct ttgcagtaac ctcagtgccg tcatataaag 1197061 ataccttcag tgatgatgcc ccttctacga cgtggttatt tgtaatgata taagccttgc 1197121 cattctcttt tttgaaaatg acacctgacc ctgaaccgct ttctgtatct tcgctggaat 1197181 cagaagaact agagccgaac aaagagctgt ttgattgtgc ctgaagattt gtaataccga 1197241 caatcgctgg tgaaaggtct tctaccatat ctgagatttt agaagagtcc tcgctcttga 1197301 atgcagatga gctgcttgag ctttttttag attcagagga ggtgcttgtt gctgtaacag 1197361 attgcgtttg ctgctggctg gatgattgtt ttgcagtgtc ctgagaatca tggtcaccaa 1197421 gcggtgtaaa cgtgtaaatg ccaagagcaa gactgccgcc gatcactccg ccaagcaacg 1197481 gtctgaacca tccgaatcct cgttttttct tctcctgatc atgaatgaca ttgcgggccg 1197541 agtaggaggc gctctgatcg ttctctttcg ttaaaaagac ctcattctca ttacctttcg 1197601 ttctgttttc atcacgatag ttatccatca tgttcactcc gtttctctat tttcacatgt 1197661 ctatttatat tgataggttt atgacttgag tttatcataa acaaaaactg tgggataaaa 1197721 atgaaaagat tatgggaaat tgtgaaaaag tgcggaaaac ggtacacttc atattgtata 1197781 tgaaaggact gagtcgatgg aacagattgg attgattgga tatggcagca tggcggatat 1197841 gatcgctaga cagctgttga aacatgaaca aataaaagag aatgagctat ttattgagac 1197901 gagaacgaag ggggagcggc tgcgggcact catgtcagat tatccaaacg tatcggctga 1197961 tccgttggag aattgggcaa atacgtgcca attgattttg atatgcgtcc cgccactcca 1198021 tgtcatcgaa acaatgcgcc gtctgtaccc gtatgtgaac agaaatactc acatcgtatc 1198081 catagctgcc ggtgtgccgc tgcgtctttt ggaggcagaa acagaagccg gtatctcacg 1198141 tgttattcct gccattacgt ccgaagcaga agccggcatc tcacttgtcg ttcacagtga 1198201 agcactggct gcagagaaaa aagaacgtct gaatgaattg ttatcggttt tcagccgtgt 1198261 acgggaaatc aaagaatcga atttagatgt ggccagcaat ttaacgagct cggcaccggg 1198321 attcatagct gcaatctttg aagaactggc actgtctgcc gtcagaaaca gcagcctgtc 1198381 caaagaagaa gcctttgatt ttctgattca ttcgctatac ggaactggca agatgctgat 1198441 cgaaaaaaat atgtctttcg aggagacgct ggaacgtgtt gcaaccaaag gcggaataac 1198501 gggagaggga gctgaggtga tacacgcctc tgtgccggac gtttttgatg aggtatttga 1198561 aagaaccctg agaaaatatg aactgcttac agaacaggtt ggtaaacaaa catgaatcct 1198621 tgaaagagga ttcttttttt atcactgaat gattgagatt tttcccagtt atattgcatt 1198681 tttcctcttt ttttaatata atttgttaga atattcataa tttagtaaaa aaggaggagc 1198741 gttatgaaat tgtacatgtc agtagatatg gaaggtattt cgggtcttcc ggacgatacc 1198801 tttgtggatt ccggcaagcg gaattatgaa cgcggacggc ttatcatgac tgaagaagca 1198861 aactactgta ttgctgaagc gtttaacagc gggtgtaccg aggtgctggt caatgacagt 1198921 cattcgaaga tgaataatct gatggttgaa aagcttcacc ctgaagcaga cttgatttct 1198981 ggtgacgtca aaccattttc aatggtggag ggactggatg atacgtttag aggcgctttg 1199041 tttctcggtt atcatgcgag agcctcgact cctggtgtca tgtcacacag catgattttc 1199101 ggcgtccgtc atttttacat aaacgatcgg cctgtcggtg agcttggatt aaatgcatac 1199161 gttgccggtt attatgatgt cccggtatta atggtagccg gggatgaccg ggcggcgaag 1199221 gaagcagaag agcttatccc gaacgtgacg acagccgcag tcaaacaaac catttcaaga 1199281 tccgcagtga agtgcttgtc gcctgcgaaa gccggacggc tgttgacaga aaaaaccgca 1199341 tttgccctgc aaaacaagga caaagtcaag ccgctcacac cgcctgacag gccagttctg 1199401 agcattgaat tcgccaatta tggccaagca gaatgggcga atctgatgcc gggaacggaa 1199461 atcaagacgg gaactacaac cgttcaattt caggcgaagg acatgcttga agcctatcag 1199521 gcgatgcttg tcatgactga gcttgcgatg cggacatcat tctgctaaag gggtgtttta 1199581 ggctttggcg cgatacatga taaagcgttt ttgggcaatg gcagctacga ttttggtgat 1199641 taccaccctg acttttgttc tcatgaaggt cattcccgga tctcctttta acgaggagag 1199701 aggcacaaat gaagccgttc aaaaaaatct cgaagcctac tatcacttag acgatcctct 1199761 cattttccaa tacattttct acttaaaatc catcattaca ttcgatttcg gaccttcaat 1199821 taaaaaaccg tcggacagcg taaatgatat gctggaacgc ggatttcccg tttcctttga 1199881 gcttgggatg acagcgattg tcattgctgt gatttctggg ctggtgctgg gcgtaatcgc 1199941 tgcactccgc cgcaatggct ttttggacta cgccgcgatg agtcttgcag tactcggcat 1200001 ctccatcccg aattttattc tggcaacatt gctcattcag caatttgctg tcaatctcaa 1200061 actatttccc gctgcgacat ggacgagccc gattcatatg gtgcttccga ccgcagcgct 1200121 tgctgtaggg ccaatggcga tcattgccag gctgacacgg tcgagcatgg tcgaagttct 1200181 gacacaggat tatatccgca cagcaaaagc aaaagggctt tctccgttca aaattatcgt 1200241 aaaacacgca ctcagaaatg cactcatgcc cgtcattacc gtcctgggca cactcgtcgc 1200301 cagcatctta acaggaagct ttgtcattga aaaaatcttt gccattccgg gaatgggaaa 1200361 atattttgtt gaaagcatta atcagcggga ctaccccgtg attatgggaa cgaccgtttt 1200421 ttacagcgtc attctgatta tcatgctgtt tttggtcgat ttggcctacg gtctcttaga 1200481 cccgcgcatt aaactgcata agaaagggtg aagcgtgtga atctccctgt acaaacggat 1200541 gaacgccagc cagaacagca caatcaggtg cctgatgagt ggtttgtctt gaatcaggaa 1200601 aaaaatcggg aagccgattc ggtcaagcgg ccgagtttgt catacacgca ggatgcctgg 1200661 aggaggctga aaaaaaataa attagcgatg gccggactct ttattctttt atttcttttt 1200721 gtcatggcag ttatcgggcc ctttttatcg ccccatagtg tcgtacgcca atcgctgaca 1200781 gaacaaaatc ttccgccctc agccgatcat tggttcggca ccgatgaact cggccgggat 1200841 gtgtttaccc gaacatggta tggcgcgaga atctcgttgt ttgtcggcgt gatggcagca 1200901 ctgattgatt ttttgatcgg tgtcatttac ggaggcgttg ccggctataa aggcggcagg 1200961 attgacagca ttatgatgcg gattatcgaa gtgctgtacg gactgccgta tctgcttgtt 1201021 gtcattttgc tgatggtgct catgggaccg ggactgggca cgattattgt ggcgctgact 1201081 gtgaccgggt gggtcggcat ggcgagaatt gtaagaggcc aggtgcttca gattaaaaat 1201141 tatgaatatg tactcgcctc gaaaaccttt ggcgcgaaaa cctttcgcat catccggaag 1201201 aatttgctgc cgaatactat gggagcgatc atcgtacaaa tgacattaac cgtacctgcc 1201261 gccatattcg cagaatcatt tttaagcttt ctcggcctgg gcatacaggc tccgtttgca 1201321 agttggggcg tgatggcgaa tgacggcctg cctacgattt tatctgggca ttggtggcgc 1201381 ctgttttttc cggccttttt catatctctg acgatgtacg cgtttaatgt gctgggggac 1201441 ggattgcagg atgcgcttga ccctaagctg aggaggtagc tgtatggaaa aagttctgtc 1201501 agtccaaaat ctgcacgtgt cttttacgac ttacggcggg acggttcagg cggtcagagg 1201561 ggtgagcttt gatttgtata aaggagaaac ctttgcgatc gtcggcgaat ccggctgcgg 1201621 caaaagcgtt acctcccaaa gcatcatggg cctgcttccg ccttattcgg cgaaggtgac 1201681 agacggcagg attctattta aaaacaaaga cctttgccgt ctctctgaca aagaaatgag 1201741 aggtataagg ggagccgaca tttctatgat ttttcaagac ccgatgacgg cgttaaaccc 1201801 tacgctgact gtcggcgacc agctggggga agcgctattg cgccacaaaa aaatgagcaa 1201861 aaaagcggca cggaaagagg tgctttccat gctgtcattg gttggtattc cagatcccgg 1201921 agagcgccta aagcaatatc cccaccaatt cagcggcggt atgagacagc ggattgtcat 1201981 tgcgatggcg ctgatttgcg agcctgatat cttaattgcg gatgaaccga ccaccgccct 1202041 ggatgtaacc attcaggcac agattttaga gctgtttaaa gagattcaga gaaaaacgga 1202101 tgtgtctgtc attctgatta cgcacgattt aggggttgtt gcccaggtag ctgacagagt 1202161 cgcagtcatg tatgccggga aaatggcgga aatcggcaca agaaaagata ttttttatca 1202221 gccgcagcac ccatatacaa aaggcctgct gggctctgtc ccgcggctgg atttaaatgg 1202281 cgctgagctg accccgattg acggaacgcc gccggattta ttttcgcctc cgccgggctg 1202341 cccgtttgcc gcccgctgtc cgaacaggat ggttgtgtgt gacagggtgt acccgggcca 1202401 gacgatcaga tctgactcgc acaccgtcaa ctgctggctg caggatcaac gagcagagca 1202461 tgcggtgctg tcaggagatg cgaaggattg aacatgaaaa gggggaagag gatgaaacga 1202521 gtgaaaaagc tatggggcat gggtcttgca ttaggacttt cgtttgcgct gatggggtgc 1202581 acagcaaatg aacaggccgg aaaagaaggc agtcatgata aggcaaaaac cagcggagaa 1202641 aaggtgctgt atgtaaataa tgaaaatgaa ccgacttcat tcgatccgcc gatcggcttt 1202701 aataatgtgt catggcagcc gttaaataac atcatggagg ggctgacgcg tcttggcaaa 1202761 gatcatgagc ccgagccggc aatggcggag aaatggtctg tttcgaaaga taataaaact 1202821 tacacattta cgattcggga aaatgcgaaa tggacaaacg gagatcctgt aacagccgga 1202881 gacttcgaat acgcgtggaa gcggatgctt gatccgaaaa aaggcgcttc atcggcattc 1202941 ctaggttatt ttattgaagg cggcgaagca tataacagcg ggaaagggaa aaaagacgat 1203001 gtgaaggtga cggcaaagga tgatcgaacc cttgaagtta cactggaagc accgcaaaaa 1203061 tatttcctga gcgttgtgtc caatcccgcg tatttcccgg taaatgaaaa ggtcgataaa 1203121 gacaatccaa agtggtttgc tgagtcggat acatttgtcg gaaacggccc gtttaagctg 1203181 acggaatgga agcatgatga cagcatcaca atggagaaaa gcgacacgta ttgggataag 1203241 gatacagtga agcttgataa ggtgaaatgg gcgatggtca gtgacagaaa tacagattac 1203301 cagatgtttc aatcagggga acttgatacc gcttatgtcc ctgctgagct gagtgatcag 1203361 ctgcttgatc aggataacgt caatattgtt gaccaggcgg gtctctattt ctatcgattt 1203421 aatgtcaaca tggagccgtt ccaaaatgaa aacatcagaa aagcctttgc gatggctgtg 1203481 gatcaagagg aaattgtaaa gtacgtcacg aaaaataatg aaaaaccggc gcacgccttt 1203541 gtatcgcctg ggtttacgca gcctgacggc aaagatttcc gtgaagcagg cggagacctg 1203601 atcaagccta acgaaagcaa agcgaagcag ctgctcgaaa agggcatgaa ggaagaaaac 1203661 tataataagc ttcctgcgat cacgcttact tacagcacaa agccggagca taaaaagatt 1203721 gccgaagcta ttcagcaaaa attgaaaaat agccttggag tcgatgtgaa gctggccaat 1203781 atggaatgga acgtattttt agaggatcaa aaagcgctga aattccaatt ctctcaaagc 1203841 tcatttttgc ctgattatgc agaccctatc agttttctgg aagcctttca aacgggaaat 1203901 tcgatgaacc gcacaggctg ggccaataaa gaatacgatc agctgatcaa acaggcgaaa 1203961 aacgaagccg atgaaaaaac acggttctct cttatgcatc aagctgaaga gctgctcatc 1204021 aatgaagcgc cgatcattcc ggtttatttt tataatcagg ttcacctgca aaatgaacaa 1204081 gtaaaaggaa ttgtccgtca ccctgtcggc tatatcgatt taaaatgggc agataaaaac 1204141 tgatggaggc gattgaggaa atactgcttc tttatgcgaa ggagcggtat tttttctctt 1204201 tcttgcacgt atacgtaggg tgcagagcaa atgaaaggag tgttttcgtt gaattacaag 1204261 ccgaaagcgt tgaacaaggg tgatacagtc ggagtgatcg cgcccgcaag tccgccggat 1204321 ccaaaaaagc ttgacaccgc gcttttattt ttagaagagc tcggtcttca ggtgaagttg 1204381 ggcaaggcgc tgaaaaacca gcacggctat ttagcgggac aggatgatga gcggctggcg 1204441 gatctccatg agatgttcag agacgatgag gtaaaagcag tgttgtgcgc atgcgggggt 1204501 tttgggacag gacgtatcgc cgcgggcatt gatttcagct tgatccgcaa acaccctaaa 1204561 atcttttggg gatacagcga tattacgttt ttacatactg ccattcatca aaacacaggt 1204621 cttgtcactt tccatggccc gatgctcagc acggatattg gccttgacga cgttcacccg 1204681 ctgacaaaag cgtcatataa gcagctcttc caggagacgg aattcaccta tacagaagag 1204741 ctttctccgc tgaccgagct tgttcctgga aaagcggaag gcgagcttgt cgggggaaat 1204801 ctgtctttgc tgacgtctac actgggcacg ccatttgaaa ttgatacgag aggaaagctt 1204861 ctgtttattg aagatattga cgaggagcct tatcaaatcg accggatgct gaatcagctg 1204921 aaaatggggg ggaagctgac ggacgcggcg ggaattctag tttgtgattt tcacaattgt 1204981 gtcccggtga agcgagagaa gtctctctcg cttgagcagg tgctggaaga ctatattatt 1205041 tctgcgggca ggcctgctct gagaggattt aaaatcggcc actgctcgcc aagtattgcc 1205101 gttccgatcg gtgcgaaagc tgctatgaat acagcagaaa aaacagccgt aatagaggcg 1205161 ggcgtttcag aaggggcgct gaagacatga aaatcattcg aatcgaaaca agccgaatcg 1205221 ctgtcccgct gacaaagccg tttaaaaccg cacttcgcac tgtgtatacg gctgaatcag 1205281 tcatagtaag gattacttat gacagcggtg cagtcggatg gggagaagca cccccgacgt 1205341 tagtgattac aggagacagc atggatagca ttgaaagtgc catccaccat gtgttgaagc 1205401 cggcattgct tggaaaaagc ctggcgggct atgaggccat tctgcacgac atccagcatc 1205461 ttcttacagg aaatatgagc gcgaaggctg ctgtagaaat ggctctatac gacggctggg 1205521 cgcagatgtg cgggctgccg ctttatcaaa tgcttggcgg atatcgagat acgctggaaa 1205581 cagattatac tgtcagtgtc aactcacctg aagagatggc agctgatgcc gagaattatc 1205641 tcaaacaagg ctttcaaacg ctgaaaataa aggtcggaaa agatgatatt gcaacagata 1205701 tcgcccgtat ccaggaaatc agaaaacgtg tcggatcagc tgtgaaactg cgtttagacg 1205761 ctaatcaggg gtggaggccg aaggaagcgg taactgccat tcggaaaatg gaggatgcgg 1205821 gcctaggcat tgagcttgtc gagcagcctg tccataaaga tgatctcgct gggcttaaaa 1205881 aggtgacaga tgcaacagat acgccgatta tggctgatga aagtgttttt acaccgcgcc 1205941 aggcgttcga agttctgcaa acccggagcg cagacttgat caatattaaa ttgatgaaag 1206001 cgggcggcat cagcggagca gagaaaatta atgccatggc ggaggcctgc ggggtggagt 1206061 gtatggtcgg cagcatgatc gaaacgaagc tgggcattac ggccgcggcg cattttgcgg 1206121 caagcaagag aaacatcaca cgctttgatt ttgacgcgcc gctgatgctg aaaacagatg 1206181 tattcaatgg cggcataaca tatagcggca gcacgatttc gatgcctggc aaaccgggcc 1206241 tcggaatcat cggggctgcg cttttgaaag gggaaaaaga gcaatgatgc acactgtcat 1206301 atcagcagtg gccaacatct ggacagcgcc tgattcacct cgtccgtctg atcaattcat 1206361 gcttcaaccg actgtaatga tcagagactg gctggagcgc atgacgtatg atgaacggct 1206421 tggattatgt acagacaatg taatccaaac tcaggttctc tttggcgaaa aggtacttgt 1206481 gacggcggaa cagggggaat gggtttctgt gatcgtgcct agccagccat cccgaaagga 1206541 tccgcgcgga tacccgggct ggatgaaaaa gtaccagctg gaaaaaacaa agcccatcca 1206601 tacacaacac gatgtgatga tcagcaaacc tgctgccttt ttgtacagaa gcaatgggga 1206661 aaaggagatc gaattaagct ttttgacagt tctgcccctt attgcaaaag aaaacggata 1206721 ttttaaggtt tcgaccgttt ttggggaaag gtttgtgagg caaagtgatg cagtgcctgt 1206781 cagccaacag aaagggactg ctgaagacat cattcaaacg ggtgcgtttt ttcttggcct 1206841 tccctacctg tggggaggga tcagcgggtt tgggtttgat tgctccggat ttatgtacag 1206901 tatatttaag gcgaatggat acagcatccc ccgtgatgcg ggagatcagg ctaaggcagg 1206961 gaagggtgtc ccgcttgatg atatgaaagc cggtgatctg ctgttttttg cttatgagga 1207021 aggaaaagga gcgattcatc acgtcggtct gtatgtaggc ggcgggaaaa tgcttcattc 1207081 tccaaagaca gggaagtcaa tcgaaatcct cacattaaca gagacaatct atgaaaaaga 1207141 attatgtgcg gtgcgccgct gtttttcaga ataaggaggg agacaaatga ggcgactgcc 1207201 tttgttagag gtcagccagc tgaaaatgca ttttgacgca gggaaaaagc ggacagtcaa 1207261 agctgtcgac ggggtcacct ttcagattcg tgaaggagaa acgttcgggc tagtcgggga 1207321 atcagggtgc gggaaatcaa ccttggggag agtgctgatg cgcctttatc agccgacaga 1207381 aggaagcgtg acataccgcg gcacaaatct tcatgcacta agtgaaaaag agcagtttgc 1207441 cttcaaccgc aaactgcaga tgatttttca ggacccttat gcttcactta acccgcgcat 1207501 gaccgttcga gaaattattt tggagccgat ggagattcat aatctctaca atacccataa 1207561 agcacggctt ctcgtcgtgg acgagctgct tgaggcagtt gggcttcacc ccgattttgg 1207621 cagccgttat ccgcatgaat tcagcggcgg gcaaaggcag agaatcggga ttgcgagagc 1207681 actgtcgctg aatcctgaat ttatcgtggc ggacgaaccg atttctgcac ttgatgtctc 1207741 tgttcaagcg caggtggtca acctgctgaa gcggcttcaa aaagagaaag ggcttacgtt 1207801 tttattcatt gcccatgatc tttcgatggt gaagcatatc agtgacagga tcggtgttat 1207861 gtacttagga cacatgatgg aaattacaga gagcggcacc ttgtatcgtg aaccgctcca 1207921 tccctataca aaggcgcttt tgtcctcgat tccgattcca gatcctgaat tggaggacaa 1207981 gcgtgagcgt attctcttga aaggggagct gccgagcccg gtcaatccgc caagcggctg 1208041 cgtgtttcgt acccgctgtc cggaggcgat gcctgaatgt ggagaatctc gtccccagct 1208101 tcaagaaatc gaacccggcc gttttgtcgc ttgccatttg tatcgaaatg ctgaaacgaa 1208161 ggaaaaagta agataaataa aaagagtggc tcctttttac tagagccact ccatttgttt 1208221 atacttgatg taaaaacttt acacaaaccg ggtaagggac agaaaccgtt gatgggagga 1208281 gtgtcaatcg gccggtttct ttgtctcttt caaacaagac aaggttgcct gtttcttcat 1208341 ttgaagcaac gaggaaccct tccgttgggt caaatacaaa gtcacgaggc cagtttcctt 1208401 ctgtcgacac tctttctacg aaagccagct ctcctgaata ttgattcact tcaaatacgg 1208461 cgatactgtc atggccgcgg tttgcgacat aaacaaaacg tccgtcctgc gtgacatgta 1208521 ttgcgcttcc ctggctgtta tctgtaaaat catcagggat ggcagaaacg acttggattt 1208581 ctctaaattc gccggctgtc gggttgtatt caagcgcaat cacttcattg cttaattctg 1208641 tcatgacata agcgtatttt tctttcggat gaaaagcgat atggcgaggt cctgcaccgg 1208701 gagcgaagga atggcttccg gattcagtca acacaccgtc tttaagctta taggtgtaga 1208761 gcttatctat acctaaatca accgctacca cataattgtg ttcaggtgtg aaccccgcgt 1208821 agtgtgtatg cggtttttct tgtctttcgt gcggcccttt tcctgtgtga gcggcctctg 1208881 aaacaggtga ttgcaagctg ccgtcttcct gaaccggaaa aacgtgtacc ttcccgctgt 1208941 gataattggc agtcagtacg aattgatttt gatcatcaac gcttacgtgg catggcgaag 1209001 ggccatcaat taactgatga ttcagaaatg tcaattcgcc gctgttttta tcgatttgat 1209061 aggcagcaac tccgccttgg ccgtctgctt tttcgatgga ataaaggatg gtgttgtttt 1209121 tattcgtcgc cacatatgtc gggttgccca gcttagcggc cagctttggc tcgctgagtg 1209181 cttttttctc agtatcaagc tcaaatgaat aaattccttc gcttccgcct tttgtatatg 1209241 ttcccacata tcctatgtat tttgtcatgc gatttccccc ttaaaaatga tgtcacctct 1209301 atattaacgt atcttgataa aataagctgt tcaaaacatg aaaaagggga agattcttca 1209361 ttcgcctcga atcagcggca ttgtgcagca cctgaaggag ccgcctgatt taataatttc 1209421 tgacaggtca atttcgataa tgtgatagcc tcttttcgat agctgttgat tgacatggcg 1209481 gttgccaggg agactgatga tcgttttttt tccgattgaa aggacgttgg tgccaagcgt 1209541 aaattgttcg tcctcgggca cctcaataag atcataacgt tttgccagca tatcggctgc 1209601 atctggctca atggcctgtg aataaattaa cgcttcgctt tcagatataa tgttaaatac 1209661 gcagtccaaa tgcaaaaatt tttcatgaag cttcactgga acgatcgtat attcaggaag 1209721 tgcctcttct agctggccga tagctgaaat gtcggtgcgc tggctgattc cgacatagac 1209781 aatgtcatca tcgataatga cgtctccgcc ttcaatactc gtatcaagca tgcgggtgta 1209841 agagatacct tggctgtgaa aaaaatcttt tataacggct tcttctcctt ggcgaatcgg 1209901 ttcagtcatg cttgacagaa aggctttttc tccgatgaca aatcctatgt ccctagtaaa 1209961 aacctgttct gggagtccgt cgcgaacggg caaaaggacg acctcaacgt tgtgtgacct 1210021 aagtgcctcc actaagcggc tgtgctggtc gttagcggtt tttacatgaa tattgtcatc 1210081 ttcaaaatgt ttttgtgttt cgtttataac atcttttatg gtcatgtgct caggtttgca 1210141 taagatcact ttttgaagtg tgccgtattc cgttcggcat accgttttgt gctgagattt 1210201 cgggatggat acgtccattt gtttttcctc ctaaagtgtg aagaatacat ttattattcc 1210261 ctcatcatga aaatcattaa accattttaa attttagaca aatggaagag aatattgttt 1210321 aataggagaa tataagtgca tttagctaaa agatcagaca tcaaagggga gaaaggtatg 1210381 gaaacaccgg aaacaagatt ttgtaaagag tcaaaggttg tgaaaaccag cagggtgttc 1210441 ccgcttgaca cgaacaacca taatacgctg tttggcggaa aattaatgag ctacatagac 1210501 gacattgcct ctatttcagc ggcgcgccat tgcagacgtg aaacggtaac agcttcaatg 1210561 gattctgtag attttttaaa gccgatcggg caaaaggatt ctgtctgcct agagtcatat 1210621 gtgacatggg tcggcacatc ttccatggaa gtatttgtga aagttattaa ggagcatttg 1210681 atgactggcg aacgggaact cgctgccaca tcctttttga catttgtcgc attagattca 1210741 aatggcaagc cggtgcctgt accgagggtt gtaccggaaa cagaagaaga aatcatgctg 1210801 cataatacag ctgtacagcg tgctaatgaa cgtaagaacc gcaagagaca cagccaggcg 1210861 cttgcaaatg cgctcggaac tgataagcct tggtgaacgt taaacccaaa acataagttg 1210921 ttttgggttt ttttgtactt ttcaatggtg attattacaa tggttagtcc gtttttgcta 1210981 ggggattcta taaaaaagca acaaatgtca tgttaaattg ataattttgt gacaacttta 1211041 ttaaagattc attttagata tatcttttat tcgtaagatc atgtatttta aagatatatt 1211101 ttaaatacat cttttcgaaa ggattgttta taaaatgtta gataacaaaa caatcgaaat 1211161 tattaaaagc actgtacccg tattgcaaca gcatggagaa acaatcactg gccgttttta 1211221 cgatcggatg tttcaagacc atccagagct tttgaacatt tttaatcaaa caaaccaaaa 1211281 gaaaaaaaca cagcgaactg cactggcaaa tgccgttatt gcagctgcgg caaacattga 1211341 ccaattagga aacatcattc cggttgtcaa acaaatcggc cacaagcacc gcagtatcgg 1211401 aattaagcct gagcactacc caatcgtcgg taaatatttg ctgattgcga ttaaagatgt 1211461 attgggagac gctgcaactc ctgacattat gcaggcatgg gaaaaagcgt acggagtcat 1211521 tgctgacgcg ttcatcggaa ttgaaaaaga catgtatgaa caggctgaag agcaagccgg 1211581 cggctggaag gagtataagc cattcgttat cgcaaaaaaa gagcgggaaa gcaaagaaat 1211641 tacatccttc tatttgaaac cggaagacag caagccgtta cctgaattcc aagcagggca 1211701 atatatcagc atcaaagtgc ggattcctga ttctgaatat acgcatatcc gccagtacag 1211761 cctgtctgat atgccgggaa aagactatta tcgaatttca gtgaagaaag atggtgtcgt 1211821 gtcttcctac ttacacgatg ggctgcagga gggagattca atagagatca gcgcaccggc 1211881 aggggacttt gttttagatc atgcatcaca aaaagatctc gttttgatca gtgccggagt 1211941 tggcattaca ccaatgatca gcatgctgaa aacatctgtt tccaaacagc ctgaacggca 1212001 aattctgttc attcatgcgg cgaaaaacag tgaatatcat gcattgcgcc atgaagtaga 1212061 agaagcagca aaacattctg ctgttaaaac agcatttgtg tatcgcgagc cgacagagga 1212121 agaccgtgca ggtgatctgc attttcatga aggacagatt gatcagcaat tcctcaaaga 1212181 actgattgcc aacacagatg cggattacta tatttgcggt tcaccgtcgt ttattacggc 1212241 aatgcataag cttgtatcag agctcggatc agcgccggag tctatccatt acgagctatt 1212301 cggcccgcaa ttaagtttgg cgcagtccgt ttgaacacat acatgaaact cttctccttt 1212361 cagagaagag ttttttattg agatataaga aggcagacaa gcgccggttt ctacatccgg 1212421 acaatcacag acccgctgcc atttgtgcat acacggtttt gctgttcttg cattgttctc 1212481 agcaattcat tgtttacctc aatcgctcta attagttgct tcattcttag ctccaaaccg 1212541 gccagcctgt cgattgtttg ctgctggtag ccctcgggtt ggggagccaa tggcagatca 1212601 aagggccaaa gggtattcga cttctgattt ttcatattgc gtattgcgcc tccaatcggt 1212661 gtcactttct attatgttat gttcaggcga tatgcacgtt cgcctagaca ctgatgcata 1212721 gagggcctgc cacggggcac aataggctca atatgaccag cggatggagg taaagatcgg 1212781 tgttatggat ggtatgggta tttttactga agccagttat cgtattttcg attgcatata 1212841 ttttgtttcg gcttgccggt aaaaaagctg tgtcacaaat gaacaatttt gacctgcttt 1212901 tgaccttcgc aatcggaacc attatcagtg agccgatcct tacatccaag ctgccgatgt 1212961 caatttatta tgcgggtgct tttttggtgc tttatcttat catgagcaag ctctctttat 1213021 ctaataaatg gcgatggctc ctagtcgtga gcccgactgt cctaatccga aacggggata 1213081 ttgatgaacg cggccttcgt aaagaaaggc tgactgttaa tgagctgctc ggaaagctga 1213141 gggaaaaggg ctatgccgac ccggctgaca ttgatcttgc tatcattgaa gaaacgggag 1213201 aagtaagcgt catcccgaaa gaggaagcga gagcggtgca ggtgcgggat ttgaatatgg 1213261 aagctgaacg gaattttatc ccgattccgc tcatactgga tggcgaaatc cttgatcata 1213321 atttgaaata tctccaaaaa aaccgatcct ggctgtttga gaagcttgag gaaaaagggt 1213381 acagccccaa actgctgtct tcgattatcc ttggcacgat gaatgcacgc ggtgatatat 1213441 cccttgattt aaataccgct aatgaaccgc agcatgatcc ttacttatat aaaccgggaa 1213501 ataacaatta agatggctct ctcttgtaat gagagctttt ttctttttta aagggaattt 1213561 ttgtttggtg tcaaatgtac ctagttagga ggggaactga acatgaagga cttatccata 1213621 agaaacgaca tggcgccaac ggtcagtttg ctgtattccg cagtggaaga aaacagtctc 1213681 cgtctggctt ccatcgtaag ccatatgaca cacagtgaac tttactataa ggggcgctgc 1213741 caaacaaaaa acagcacggc tcagcttttg caccatatca caaatgttga tatcagatgg 1213801 gtctggcgta tcaaggaaaa tcggatcccg gaccatattg aacaggcata cggcccgatg 1213861 acagatgaaa gcggacggct gcctgaaccg gtgaatcagc cagacttaga tgaactcctg 1213921 aaaagacatc agcatgtagt agagaagctg aaatcggtat gcttcacttt aactgaaaat 1213981 gctttgaacc agccgctttc cttcgaaggt gacaccgcga cgatacgatg gggaatttgg 1214041 catatggcag atcataaccg ctatcatcag gcacatattg aagctctcaa aaaagaatgg 1214101 aagcaggatg tggcgaagta tgaacgctaa aacgaagctt gtgactgatc gaattcgttt 1214161 gcgctgtatg gaagatcggg atcaagccac tttgtttggg ctgcttttta atgatcctga 1214221 cgtcatgaca tattattccg gtttaaaaga taagaggcaa acccgcgagt gggtcaattg 1214281 gaaccaacga aatgaaaaag ggtacggcgt tagtctgtgg atcgccgaag ataagcggac 1214341 aggggagttt ttggggcaat gcggcatcgt tccccagcag atcgaaaatc aaaccgtaat 1214401 ggaaattggc tatatgtttg cccgccgcca ctgggggaac ggctatgcgc aagaagcggc 1214461 tcgggcctgt ctggactatg gctttaacga gcggcagttc ggcaaaatgg cggctttgat 1214521 tgatccgggt aacaaagcgt ccatacgggt agcggagaaa atcggcatgc attacagcaa 1214581 aacgatcaga aaatggaata aaccgatcgc ggtatatgaa agaaaatctt acaattgaaa 1214641 gatagagctg agtttagtat catgatatca tgtaaagttt tctagggttc cgcatgtcaa 1214701 ttgacatgga ctggtccgag agaaaacaca tacgcgtaaa tagaagcgcg tatgcacacg 1214761 gagggaaaaa agcccgggag agtcaatctc atgtgagacg actgtccggg gtttttttgt 1214821 tttcggagaa tcttaataga tagaaaggaa tgactcaaaa tgaaatgggg attggtcgtg 1214881 cttgccgctg ttttcgaggt tgtttgggtg ataggcttaa agcacgctga ctcagcctta 1214941 acatggagcg gcactgccat cggcatcata ttcagctttt accttctaat gaaggcgact 1215001 cacagtctgc ctgttggtac cgtgtatgcc gtctttaccg ggctcggcac agcgggaaca 1215061 gtacttagtg aaatcgttct ttttcatgaa ccggttggat ggccgaagct attgttaatt 1215121 ggcgtgctct taatcggtgt aatcgggttg aagcttgtga cacaggatga gacagaggaa 1215181 aaaggaggcg aggcataatg ctgcactgga tcagtttatt gtgcgcgggc tgtttagaaa 1215241 tggccggcgt ggcccttatg aatcaatatg cgaaagaaaa aagcgtgaaa tgggtgctgt 1215301 tgatcattgt tggttttgcc gcttcatttt ccttgctgtc gtacgcaatg gaaaccactc 1215361 cgatgggaac ggcttacgcg gtctggacag gaattggcac cgccggcggg gcgcttatcg 1215421 gcatcctctt ttacaaggag cagaaagacg ccaaacggat cttctttatc gcgttgattt 1215481 tatgctcagc agttggttta aaaattctgt cataaattga tttttatcaa atcttcagta 1215541 taatggataa atagtttaga cttacaaaga taagagggat tattcatgaa atcatatatg 1215601 actcagcggt tggacgaata ccgtgacgga aatgaggata aaggtcggct cttggtcagc 1215661 tgccccgatc agccgggtat cgtctctgca gtttccgcgt ttttatttga acacggtgcc 1215721 aatattatag aatcaaatca atatacgaca gaccctgaag gcggccggtt cttcctgaga 1215781 atcgaattcg actgcgcagg cattcgtgaa aaaaaatcat cacttcaggc agcgtttgcc 1215841 tctgttgcgg aaaaattcga catgacatgg agcttaactt tggcgagcga actgaagcgt 1215901 gtcgccattt tcgtttcaaa ggagctccac tgcctgcatg agctgatttg ggaatggcaa 1215961 accggcaacc tgatggcgga gatcgctgtt gtcatcagta accatgagga agcgagagag 1216021 ctggttgagc gcctgaacat tccattccac tatatgaaag cgaacaaaga catcagagcg 1216081 gaagtcgaaa agaagcagct tgaactgctg gagcagtacg atgttgatgt gatcgtgctc 1216141 gcacgctata tgcagattct aactcctgat tttgtttcgg ctcatccgaa tcgcatcatc 1216201 aatatccacc attcattcct gccagctttt atcggtgcga atccgtacaa acgggcctac 1216261 gagcgcggcg tgaaactgat cggtgcgaca tctcattatg tgacaaacga tcttgatgaa 1216321 gggccgatca ttgaacagga tattgagcgt gtggaccacc gcgataatgc ggaagcgctg 1216381 aaaaacatcg gaagaacaat tgagcgcagc gtgcttgccc gtgctgtgaa atggcatttg 1216441 gaagaccgtg tcatcgttca tgaaaataaa acaatcgtct ttaactagac tgcaagaggc 1216501 ccgcgcaatg cgggctattt ttgatgacaa aaaaccttga caagtgtctt ttttctttgc 1216561 ataatataaa aaaatcattg agcgttgaag aggattagta agcagacctt tctgtgacag 1216621 agagcaaaat gaatcgctga aacattttgc cgcatgaaac ctgccgaacc tgccttggag 1216681 tcctaggggg aaaacctagg cgcataacct ggcgttacag gagagcggag cgtgcacaag 1216741 cgcgttcaat caaggtggta ccacggaaac ccatttcgtc cttatgaatc aggatgaaat 1216801 gggttttttt attgtagaag agccgcggag gagaataaat gaaaaaacaa agaatagtag 1216861 tgaaaatagg aagcagttcg ctcacgaata gcaaaggaag cattgatgag gcaaaaatca 1216921 gagagcatgt tcaggcgatt tccgtgttaa aaaaagcggg gcatgaaatg attctgatta 1216981 cctcgggtgc cgtagcggcg gggttttcca gcctcggtta tccatcccgt cccgttacca 1217041 tcaaaggaaa acaggcggcg gccgcggtcg gacaaacact gttaatgcag caatatatga 1217101 atcaatttaa acaatactca ctgactccgg gacaaatcct tttaacgaga aatgattttt 1217161 cgaaaagaga acggtatcga aacgcgtatg ctacgataat ggaattatta gagcggggcg 1217221 tcattccgat tatcaacgag aacgattcta catctgttga agaattgaca ttcggagata 1217281 atgatatgct ttctgcgtta gtcagcggat tgattcacgc ggaccagctc atgattctca 1217341 ctgacattaa cggactgtat gatgccaatc caaatgaaaa tcctgaggcg aaacgatttg 1217401 attatttgcc agagatcacg cctgaattgc ttggatatgc aggttcagct ggatcaaagg 1217461 tcggcaccgg cggaatgaaa tcaaagctgt tagccacaca aaccgcgctg tctctgggag 1217521 tgaaagtatt cattggaact ggcagcggag agcaaaaact tgcggacatt ttggacggca 1217581 ggggagacgg cacttatatc ggagacaaag aactatcttc ggttaacaac acaaggcagt 1217641 ggattcagtt ccactcgccg atatcgggag aaattatcat tgatgcgggt gccgaagagg 1217701 cgatgatcca taatggaagc agccttttgc ccgctggagt tgtgggcgtg aacggaagct 1217761 ttccgaaagg ggcggttgtg gaagtcaggg gaccgggcgg cgtgatcggc aaaggccaaa 1217821 ctcattactc ctccgaggag attatggagg ctaaaggcaa acgcagtgac gaacttgatt 1217881 ttgagaaaac gtttgaggtt attcatagga atgactgggt caatgtaaaa gactaggagg 1217941 cggaaaaatg agtgaagttt ctgtaaaagc gaagctggcg aaagaagcag cagccgaaat 1218001 gatcatgaaa acaacagccg agaaggatga ggcgctcagc ctcattgcaa acggactccg 1218061 caaagaactg gattttctct tggcggagaa tgcaaaagac attgtgaacg gaaaagagaa 1218121 tggtttaaca ccggacatca ttgaccgtct ctcattggat gagaaacgga tacgcgatat 1218181 cgcggacgcg gtggagctct taatcgactt agcggaccca atcggcgact ctcttgaaac 1218241 gattgaaaaa gaaaacggcc tgtttattga aaaaatccgt gtgccgctcg gtgtcgtagg 1218301 aatgatttat gaggcgaggc caaacgtcac agttgatgcg gctacccttt gcctgaagac 1218361 agggaacgcg gttgtgctgc ggggaagctc ctcagccatc cacagcaaca aagcgctcgt 1218421 cagtgtcatt tacagagcac ttgagcaatc agcgcttccg attcacgctg tgcagctgat 1218481 tgaggatacg agcagagaga cagcaaaaga gctctttacg ttaaatgatg gcttagacgt 1218541 attgattccg cgcggaggca agaaactgat tgatctcgtt gtgagagaat caacagttcc 1218601 tgtattagaa acgggagcag gaaactgcca catattcatt gacgaaacag ccaaaccgca 1218661 aatggcagaa aaggttgttg taaatgccaa aacgcagcgc ccttctgtat gcaacgcgat 1218721 tgaatcattg ctgattcaca aggcttgggc aagacagcac ggaaaagaat tgctggacca 1218781 gctggaaaac gcgggagttg aaattcgcgg tgatgaattg gtatgtgaac ttcatccttc 1218841 aagcaaacaa gcatcaaaag aagattggga aaccgaattt ttagcgcctg tcctcagcgt 1218901 aaagacggtt gaaaacgtcc aagaagctgt aaagcatatc caacaatacg gcaccaatca 1218961 ttctgaagcg attttaactg aaaatgacaa aaatgcggta tattttcaaa cggctgtcga 1219021 tgctgccgct gtctatcata acgcgtcaac ccgctttacc gacggctttg aattcggcta 1219081 cggagccgaa atcggcatca gcacgcaaaa gcttcatgca agaggaccga tggggcttcc 1219141 tgcactgact tctacaaaat acatcattaa aggaactggg caaatccgtg aatagcgggg 1219201 taatgttcaa tgaaaaagct tatctcatta cgagataagc ttttttatac gcgaaaaatt 1219261 gacatttcaa atttaattgt gtacaattta attgtataaa atatattggg ggaatgaaaa 1219321 atgagtcagc cattatttac cgcaactgtt tcagcggtag gaggaagaga aggaaaggtc 1219381 atttcatcag accgcgttct tgagcttgat gtcgcaatgc cggggacacc gagagccaag 1219441 aaattagaaa aagcgacaaa tccagagcag ctgtttgcag caggttatgc agcttgcttt 1219501 gacagcgccc tgcagcttgt cgcaagaaca gaacgggtaa aagtagagac agaggttaca 1219561 gcaaatgtta gcctgttaaa ggatgaagcg gaccagggct ataagctggg tgtgacgctg 1219621 caagtaaaag gagaaggagt cagtgcatca gaattggagg cgcttgtgaa aaaagcgcac 1219681 ggcgtctgcc cgtactcaaa agcaacctcc ggaaatattg atgtgacact tgaagttgct 1219741 gaataaataa aaagaggatg cctgtacaag gcatcctcaa tttttttgat gaagtgtttc 1219801 cagtaatgta tatagagcgg actttaactg tttgagatcc tccccagact gctttgagag 1219861 ccccagaatt gtccctggaa tgtcaaccgc tttttctttt aataacgctc cgtcctctgt 1219921 caggctgatc aacacggacc gctcatcctc ttcagatctt tttctcgtaa tcaaaccctg 1219981 ttgttccatt cgtttaagca tcggagtgag cgttcctgaa tctaaataca gctgttcgcc 1220041 catttttttg acagtaagcg tttcatgttc ccataacaaa agcaaagcca aatattgagg 1220101 gtatgttata ttcagcttat caagcagcgg cttgtattgc tttgtcatct cccgcgaact 1220161 cgcatatagc aaaaaacaaa gctgattctc caatttcata tgatcaaatt tattttccat 1220221 tttgttcacc aactcttttt tgtcattcga ttctattgta tctgaaaaac ctcacttttc 1220281 ctattctcgg caaacatagc atgtttaaaa agatcagaaa gggaaatata acaactagat 1220341 acaaataagg aggttgggaa atatggcact atttacagca aaagtaaccg cgcgaggcgg 1220401 acgagcagga catattacat cagatgacgg tgttcttgat tttgatattg tcatgccaaa 1220461 tgccaaaaaa gaaggacaaa ccggcacaaa tccggaacag ctctttgcgg cagggtatgc 1220521 tgcatgcttc ggcggcgcgc tcgaacacgt agccaaagag cagaatatcg aaattgattc 1220581 ggagattgaa gggcaggtca gcctcatgaa ggatgagagc gacggcgggt ttaaaatcgg 1220641 tgtcacactt gttgtgaaca cgaaagattt agatcgggaa aaggcacaag agcttgtcaa 1220701 cgccgctcat gaattctgtc cttactcaaa ggcaaccaga ggaaatgttg atgtaaaact 1220761 agaattaaaa taatgaccgg catcctgagg attctcagga tgttttttgg tgtcggacat 1220821 gcggggcggg cacagattta tgataaaact tcagagaagc gtttgaagca tgcctttaaa 1220881 ccaaaagtta cagatgaagc gggtggctgg cacggtgtct gccgtgctga attgcgcgta 1220941 tatgctgttt tgtatttgca cagggcatag cggctacttg gagaaataac aaggaccagg 1221001 ccgcgcatgc ctgatccttt taatattctt tcttattggc gaagttccgc catgcttgaa 1221061 acggggataa atgctctgtt agtgtcactt gataaaaggg gatcgttctt tcttcagcag 1221121 gtttatcaat ttctttataa atgaatgaat catcaaaccc ggcttcggca gcgtctgtgt 1221181 gctcagctgc atagaaaacg gctttaggcc gggcccagta gatggcgccc aagcacattg 1221241 ggcatggttc acagctcgta tacaaaatgc agtcatcaag ctggtaggct cctagcacct 1221301 tacaggcttt ccgaatagct gtgacttccg cgtgggcagt cggatcattg cttgttgtga 1221361 cgttgttctg tccctctgca ataatggctc cgtctttcac gataacggct ccaaaaggcc 1221421 cgccgattcc tgcattcact ccttcacatg cgagagtgac agcccgtttt aagaacgttt 1221481 catgattcat cccaatccct cctgtcaata gagtgttatt agtatagccg aaaagaatgc 1221541 aaagaacatt cttaaaaaag tgcaaaataa acaaagtatt tgggggattt gctaaataag 1221601 aaaccgattg tggctgtatt atagaaaaaa accatctgcc aaatgcagat ggttttttca 1221661 aattatacta gctgtgtctg ctgtgctctt gcctgttttg cggcttcaac catatttttc 1221721 aatgctgcaa ccgtttcttc ctgctgtctt gttttcaatc cgcagtctgg atttacccag 1221781 aagcggtcag tcggacagac ggcaagcgca tcaacgataa tattgtacat ttcttcagtt 1221841 gacggcacac gagggctgtg aatgtcatat acaccaaggc caagcccttt caaatacggg 1221901 tggtttttta agtaatctaa aaatcctccg tggcttctgc tatgttcgat tgtaatcaca 1221961 tcggcatcaa gatcattgat tgtatcaacg atatcttcga agttgctgta gcacatatgt 1222021 gtatgaattt gtgtctcgtt tttcacggaa gaagtggtta atctgaaagc ttctgccgcc 1222081 caagtcaaat actcatccca atcgcgggtt ttcaatggaa ggccttcacg cagcgctggt 1222141 tcatcgactt gaatgatttg aatgcctgcg tcttcaagcg ctttaacttc tttgcgaagg 1222201 gcaagcccga tttggaaggc gatttctttc ctcgagatgt cgtttcgagg gaaagaccag 1222261 tttaagattg taaccgggcc cgtcagcatt cctttcacat gcttggaagt caatgactgt 1222321 gcgtagactg tgtctttcac tgtcatcggt tcaataaatt caacatctcc gtaaatgact 1222381 ggcgggcgga cacagcgtga gccgtatgat tgaacccagg catatttagt gaaggcgaaa 1222441 ccggccagct tttcaccgaa gtattcgacc atgtctgtcc gttcaaattc gccgtgaaca 1222501 aggacatcaa gctccaattc ttcctgaata tcaatccatc tttttgtttc cgcattgata 1222561 aagttttgat actgttcatc ggaccactca gctttccgcc atttttggcg tgcgctccgc 1222621 acttcagcag actgcgggaa gctgccgatc gttgtcgtcg gcaaaagcgg aaggccgaga 1222681 gattcatttt gtagggctaa acgttcttca aacggaatcg ggcgcttgaa gtctttatca 1222741 gttaattgct caagctcttt cttttgttca gaattggcgc ctgttgcaaa ctgtttaagc 1222801 gcctggatat cagccttagc ctgctgaatc tcttcgctga tcgccgcttt tcctgatact 1222861 aagccttctt tcaaagctgt cagctcggcc agcttttctt ttgcgtagga taatccgttc 1222921 aataggtctt tttccaaatg ctcatcaggg tgtttcgcta ctggaacatg cagcaggctg 1222981 ctggaaggct gaatccacag ttcatcaact tttgcaatgc tgagaatatc aagaacggca 1223041 tcgagacgct cttcaaggtc cgctttccaa atgttgcgtc cgtcgataac gccggctgcc 1223101 agcactttat ctgtcgggaa gccatgtgtt ttaagctgtt ccaggtttct gcctttgtcg 1223161 tgaacgaaat caaggccaat tccctgaacc gggtaagaga tcagctcttc ataagcatca 1223221 acagaatcaa aatacgtctg caaaagcaca ttcaaggatg aaagctcact tgtaatgctt 1223281 tcaaataatt cttttgcgcc gcgtacatct tcactagagg cggtaacgag cgccggctca 1223341 tcgatttgaa cccattttac gccttcttct tcaagctctt tcaaaagctg tacatataat 1223401 ggcacaaggc gtttttggat cgcttttgct tcagacggtt catagccttt agcaagcgta 1223461 acgaacgtat aagggccgac aatcacaggc tttgtttcca caccgtattc ctgtttgatc 1223521 cggcgataat cttcgagttg tttgtttctt gtcagacgga actcaatgct ctcgtcatat 1223581 tccggaacga tgtaatggta atttgtatta aaccattttg tcatttcact agatacagcg 1223641 tctttgattc cgcgggcgat agcgaagtat gtatcggtag cgtcagtcaa atgtctgaac 1223701 cgtttcggga tccagttgaa gctgactgct gtgtcgagta catggtcata ctgtgtgaaa 1223761 tcagaaacag gcacaacatc aatctgctgg tcaatttgtg tttttactgc ggataaaaat 1223821 agttcgtcga tttgcttcaa aaacgtatct ttatcagtac tgcctttcca atacgcttca 1223881 agtgcttttt tccattcccg gttcagtccg attctcggaa atcctaaatt cgatgttttg 1223941 atggttgtca ttgtttctcc tcctttatat gtaaaacact ctctttcacc cgcggataca 1224001 ggctgctaag aggttttctc acaacaaaaa gcctctttcc catgagagaa agaggctttt 1224061 ctacgtaaaa cactgcctct ctcatctctc agacacaatc tgatggaatt agcaccgtgc 1224121 cttatgagac atcagtctcg gcgcgaaaag cagtgcgccc catttcacaa tggtattacg 1224181 gtcggttgct gttggggtca aaaggccaat ccctcgccca actctcgata agagaaaatg 1224241 ttattaattt tttgaaaagt tgaatcattt gttggtaatc ttaacagtaa ttcaaattca 1224301 ttgtcaacat agaatttgaa atttttattt acatgatgtg gtgtatatta tataagaaaa 1224361 ataatcttat agggtcaaca aatgtgattg ctctgctttt tctgcgagct catcaggagc 1224421 tgttaaatac aggaatccat tgcctgccag cgtttttgca atatcaagag gaagtgtcct 1224481 gcggattagc tgtgcgaaaa cctcagattc agaaagcttt ctttgaaatg attcttcttc 1224541 atagcttttg attaaagcaa gcgcaccgct gacatgaggg gcagccattg aagtgccggt 1224601 cagcttaccg tacttcttgt tgggaagggt ggataagatg ttttctcctg gtgccacaag 1224661 gtcaatctct ttattcgcgt tagaaaattc tgataattct cgcgctacag aaacagatcc 1224721 aactgcaatc acttcattat aagctgcggg gtaggaaagc tcttctgtgc gttcgtcgcc 1224781 gtcaccttca tttcccgctg cacaaacgac aagcactccg tttttcactg cgtttttcac 1224841 tgcttctttt agctctggca catcgcttgg ccctccaagg gacattgaga tgatgtcgac 1224901 tttctgttcc accgcgtagt tgatgccgtt aattatccat tcgtattgtc cgctgccgtt 1224961 ctcgccgcca agaaccttca caatcaatag gcttgcctca ggcgcgactc cggcaatgcc 1225021 tccgtttgaa tcattagctg caattgttcc ggcgacgtgt gtgccgtgtc cgttgtagtc 1225081 ggaaatcgca tcttccttgc cgccgtcgtc atccgtgaag ttctttccgc cgatgatttg 1225141 attttttaaa tcagggtggc ttgtgtcgca gcctgtgtct aatacagcaa ctttaatatt 1225201 tttgcctttt accccttttg cccacatttc tggcgcctta atcactttaa tgccctcagg 1225261 aagctcgttt acatccatga tctgctcatt cgtcacatac gggatcaagc ggatttcacc 1225321 attcataaaa aagccctcct tttttatgct tgcaagtgga ttcaagggtg ttgcctcata 1225381 ttatatgaaa aaagcaagcg ctcggacaga gccatttgaa gcattttgaa aaaataggat 1225441 acacaccaaa gaattagtaa tcttcaaaat attggatggc ttcaacatgt atgactggga 1225501 ttcaactgta agtcaagtta taatagtgtt ggggaaagga gcagtgtcat gaaactgaat 1225561 gaaaaattat atgcattttt ttcagagcat gtggaacaaa tggccgagga atggattgaa 1225621 acgatggagg aaagtgatcc gaattcgctt tacgccctac ataatgcaac agtaacggaa 1225681 gaattgaaag agcaggacag agaattttac cggcatctga attacatgta tgttttaccg 1225741 gaaaaacaat ttctcgaaga gtttcaagag tgggtcattg agctgaccaa cgatcaaaaa 1225801 catctcgaca caccggttca gtatgtcatt cgggagttta tgagaaacag gagattatat 1225861 acgaagtatt ttgagaagtt cgcagaagaa aatgaatcag cgtttgaacc gggagagaag 1225921 caaaaatggg cagatttgat tgtaaaagta tttgatttca ccatttatac attcgttgat 1225981 cacgctgaaa tgaatgccaa gcagcaatta aacgcccaaa gagaaatgat attggaatta 1226041 agctcacctg tcattaccct gagcaaatca acagctctgc tgccgcttgt cggtgacatt 1226101 gataccgaac gggcgaagtt tattctggaa aacacgcttc aagcttgtgc gaaaagacgt 1226161 gtggagcatc tgttaatcga tctgtcaggt gttgttgtgg tggatacgat ggtggcgcac 1226221 cagatcttta aattgattga ggcgcttaat ctgatcggtg tccggtcaac cctgtcagga 1226281 atcaggcctg aaattgcgca aactgctgta cagctgggga ttgacttttc gaatattact 1226341 attaaaacca accttgccca agcattaaac tatcatcaat aaaaaaatcc gctatctgtg 1226401 atagcggatt ttttatgatg cgaaacataa agatacgaga aaggatcccg cgaataataa 1226461 gaggacgagg caaaagaaca cccagtcgcg ccggttcacg ctcaatgtcc tgtagtatgt 1226521 ccggtttctg cttcctgtaa atcctttcga ttccatcgca agcgctgtcc gttccgcttt 1226581 tctgatggcg cttgccaata gcggtatggt atatcgtttt aacgcactga ttttattaat 1226641 gatgccgctc tccgccgctc ctcctctgat tttatgagcc tgctgaatca gctggacctc 1226701 atcctttaac agcggaagaa agcgaaagcc tgcaatgaca ccgtacgcga gctttggtga 1226761 gagcctgcac tgctggacaa ggctcagcat aaatagaatc ggatcggttg taaaaacaaa 1226821 catcatcgat aaggcggaaa agcataaaat acgaaacccg agagagatgc cgacagacac 1226881 attatcgctg ttaatggaga tagggcctgc ttgaaacaaa aaattatccg gtgttgtcgg 1226941 cacttttcca aaaactgcgg ctgtccacac gcatccgaat gctaaaatca aaaacggaat 1227001 cgtaaacaac aaccattttt tcaatgggat tccggccgcc agtaaaacgc ccgcaacgat 1227061 gatgatataa aaacatgccg gagtgtaagg gttgtaaata aacgacagca tgacgacaca 1227121 acaaaaaacc gccgccgctt tcacagtcgg attaatgaga tgtaacggtt gcttcatcac 1227181 gcacctcctc ttgaaatgcc atccattcat atagaagggg aagggtgagc tttgcttttt 1227241 gaacaagccc tgtttcttga gaaaacaact gcgctggaga tccgtcaaag gccaggcctg 1227301 tatcgtgaag cacaagcacg ctgtcagcat acgaagagac tagctccata tcgtgtgtaa 1227361 tcataaggac agcagttccc tctgccttga tacgttgaat catttccatg cattcagccg 1227421 ccgtgcgggc atcctggcca aaggttggtt cgtctaataa taaaaccttt acgtcatgca 1227481 tgagcatagt agctacgctc agtcgccgtt tttgcccttg gctgatcgca aacggatgat 1227541 gatcagccaa atgcgcaaga ccaaaacgct gcagcaggtg ttgcgctttt ttctcagttt 1227601 cagcatttgc tttctggccg aacagaagct cgtcatacac cgtatcggtg acgaattgat 1227661 gctcagggtt ttgaaaaaca aatcccatcc gtttacgcaa ttctttttct ttatatttct 1227721 gcagcggctg atcatagaga aggattttgc cgctttgcgg tttcatgaga ctggccagaa 1227781 ctgataggag cgtcgatttt ccagttccgt tcggaccgac aagcgccgtt aaagagcctt 1227841 cgcgcaacga aaagctgatg tctttgaaaa tcgcctgctg tcctctcgcg aacgaaaggc 1227901 tgctgacttc aagcacactc tccccagaag gggctttctt ctttttgaca tgcccggcag 1227961 gaataggctc tttgaacagc atctcttttg ataaagtaaa cggcatactc agcttttcct 1228021 gcagatgaca gacctttgga atggcgatgc ccaatttctt tagtgtctcc gcttcatgct 1228081 gaaatagatt tttcgtcagg ccatccagtg cctttttgcc tgatttgtcg agtacgatcg 1228141 ttctctcaat ccaaggcgcc cattcatcaa gctggtgctc aatgacgagg aggctgaaac 1228201 ctttttcccg ctgaagatcc ttcatcagat gaacgaactc ccgagctgag aaagggtcta 1228261 aaagagaggt cggctcatct aaaataataa gctcaggctc catcgccaaa atacaggcga 1228321 gagccacttt ctgcttttgt cctcctgaaa gggttgagat cattttttct tttaaatggg 1228381 taatgcgtaa tttttctaat acggcgttga ttttctctgt catttcttct tttggaattt 1228441 gcagattttc cagcccgaac gctatttcgt cctccaccgt cagcatgcag aactgctgat 1228501 caggatcctg aaaaacgacc ccggcatgct gagtaatcgt ttcggaggtt tcagcatctg 1228561 tgaccggctt ttgaaataga aatacatgtc cggactgaat gccgtcgcaa gcctccggat 1228621 atagaccgtt taaacaaagg gcgagcgagc ttttaccgca tccgctcggt cctaataata 1228681 aaacacattc tcctttttga agctcaaacg aaatgtcttg aaaaaccggt ttctcgtctt 1228741 cttcataaga gaagctgagc tgctcaaccg tcagaagctc atcaaaggct tgcatgttct 1228801 gacgcccgct tccgtttctt tttcagttcc tttccgagtg ccattccgtt taacacacct 1228861 gtataagcga gagagtcgct gacagctttt ccgagaagcc ccgccaaaag cgcgccggaa 1228921 atgaggcgga tcacaagcat aatgagcaga taacctggtg aataggctgc atagccagaa 1228981 acaaagagat catagataaa gctggctact gaagacccca taccggccag cataaggaca 1229041 gggagagagt atgctttcca gcgtgttgca agaaatacag cctcagcccc gagcccttga 1229101 acaatgccaa tgacgatgac catcgggcca gacggatttc ccagcaggca ctcaacgaga 1229161 gcggcaatga tttcagaaac gagcgccgca cccggttttc gaatcatgta cgcggcgatc 1229221 acagaaacga taaaccaaat gccgtaaatt ggttcatagg cgattggccc aaacatacct 1229281 gcaagtacgt ttccgaaatg tgtaaataat aaataaacaa cggcaaatac gatactgata 1229341 acggacatga tgacaatttc ttttactttc cagcttttca tgttatccct gctttctgtt 1229401 ttttcttgat ggactgttag ccgaaagatt cacagtcatg gtgatgtggt ttgtttgctg 1229461 ctcagccatg cggaaaacgg cctccaatgt gctgaatacg tcatgcgcat ccccgtcaag 1229521 ctcgctcgcg taatggacac cctgtacgaa agtgccttgg gcttttgcaa tgtcgacagc 1229581 ctccataatc aatcccatat aatccggctc attcattgga taaagggcaa attggcacgg 1229641 cgcttccgcc ttcaagcctc ggacagcatc ttcattgaca cgcttatcac ctttggaaag 1229701 atatgtatcc ccctgtgtgt cacccgggca tccaatggaa aacgtgccgt tcatgacgat 1229761 gtgttgttcg ctgtttgctg catgaaggta aatggctttt gcagcatcga atacatgatc 1229821 aatcgatccg cgtaacaccg tgctgatatg gtcggttttc gtccaaacct tggatgtatc 1229881 tgtttttttc agcgcagact tgatcacact gataaaatca tccgtcatcg gatataaaga 1229941 gaagcgaaaa ccggcgattc tgcttgtacc gcaaatatgc tccatttctc cgacctcctg 1230001 tttttttggt aaaataaaaa actgcatatc ctaagggaat atgcagtcat agatcgatta 1230061 agcgcacaaa aaaatacacc attcggtcaa cctgcacttc cccacgctgg tattatccag 1230121 atcgggtcat aagggatcaa agcgcgtttc ttccgcgctt tatctcagcc aaaacagcac 1230181 ccctagtgct ttccgtatac aattttttat tttgacatca taatagatga taagaatcat 1230241 tttgtaaaca acgaaatcat ttttttcata tagggacggg agaggatggt caaatttgga 1230301 aaaaggacac atattaattg tggaagatga agaaaaaatc gccagggttc ttcagcttga 1230361 attggaatat gaaggataca gcgtcacgat caaacacaat ggcacagaag gtcttgatgc 1230421 ggcagcggaa ggcgggtatt ccttggtgct tcttgatgtc atgcttccgg ggcttagcgg 1230481 actggaagtg ctgcgccgct tgagaaaaac ggattcgcag acaccggtca tattattaac 1230541 ggcgcgagac agtattcctg ataaggtaac aggtctggac atcggtgcaa atgactatgt 1230601 caccaagccg tttgaaatcg aggaattgct tgcgagaatc agggcggcgc tgcggcaaaa 1230661 tggaacaaaa actgaagata tcggcacctt tcttacatat gacgatttgc gggtgaacga 1230721 aaaaacccgt gaagtgagac gcggagacaa agaggtggaa ttaacgccgc gggaatttga 1230781 tctgctcgtc tatatgctaa agcatccgca gcaagtgctg acacgggagc aaattctaag 1230841 ctcagtatgg ggatttgatt atatcggtga tacaaatgtc gtggacgtct acataagata 1230901 catcagaaaa aaactggact atccttacga aaaacagctg atccatacga ttcgcggggt 1230961 cggctatgcc attaaggggt aaacgatgaa gctgaagacc aagattcatc tatacacttc 1231021 gatatcactg ttgattttat taattttggt tcataccgca gtatatctca ttttttcgtc 1231081 tgcgctgaca tcaaaggatg cggcccggct tgctgatgag acggataaca ttgccgaagc 1231141 gctgcgtgcc gctgaaacag aaggagtggc tttgcaggat atgctgcagg cctatcttcc 1231201 ggcaaatggc atggtgcgtg tagtgaatgg tgatcaaaaa gccgttatga cgatcacaaa 1231261 agaaaaagcc tataaagatt ttcctctctc ttttcatagc ggcgaaacgg cagatgtgag 1231321 gaaacctgac ggcaagctgt ttgccgaggc tgctgttccg gtgatttgga ccgatggaca 1231381 agtcgtgtct cttcagctgg ttgaaagact ggagaacaca gaagagagtc tgtttctgct 1231441 gaaaatcatc ttaatcgctg caagtgctgc tgtctgcatt gcttcttttt ttgcaggcag 1231501 cttgctagcc cgccgaatca tcaatccgat cagacgatta atgatcacaa tgaaagacat 1231561 acagcgagac aaagaattta aaacgatttc tttagaagga cagtccaacg atgaattgta 1231621 tcaaatgggg ctgacattta atgaaatggc aatgatgctg aaggagcact atgataaaca 1231681 gcagcaattt gttcaagatg cttcacacga attgaaaacc ccgctcacta ttatagaaag 1231741 ctacagcagc ctgatgaagc ggtggggtgc aaaaaagccg gaggtgcttg aggagtcgat 1231801 agaagccatt cactcagaag cggtgcatat gaaaaaactg accaatcagc ttttggcgct 1231861 ggccaaaagc catcaaggac tcgaggttga tctgaaaaca atcgatctga ttaaagcggc 1231921 gcgcgcggtt atgcaaacgc tccagtccgt ttatcagcgt gacatattgc ttgaaacaga 1231981 taaagagagc ctgcttgtaa aggcagatga agaacgcatc aagcagctgt tgaccatttt 1232041 gcttgataat gcaataaagt atagtgaaaa gcctattgag atgtcagccg gaacgaggaa 1232101 tggacggcca tttctatcag tgagggatga aggcatcgga atacctgagg agcatatccc 1232161 gcatttgttc gaacggttct accgggcaga tgaggcacga aacagaaaaa caggcggaac 1232221 aggtttaggc ctttccattg ccaagcaaat cgctgatgag catggcattg agctgtctgt 1232281 caaaagcaag ccgggacaag gaacagctgt caccatgcaa ttcagcgaac agaatggggg 1232341 aggccgatga ctaaaacaat aaaaacagta tcttttgctg cagcagccat tttagttgtc 1232401 atcatctgta cgtttctcat cattcggcaa acccatgaga acgtattgtc aaaggagact 1232461 gtcgtaaaaa aagtcgaagc ctcttatgaa ggcaaggtca cgaaagcaac acaatcaaag 1232521 gataaaaaaa catatgatat aacccttgaa aatccaaagg gaacttactt tgtaaaagca 1232581 gacgcaatat cggctgacat tctttcaatg aatagagtaa aagcagtgaa tccatctgcc 1232641 atgacagaaa aagaagccga gcatctcgcg cttgagcggg tgccgggaac ggtcaaaaaa 1232701 caaacacggc aaagtcaagt tgccacttat accatacaaa aagaagacgg gaaaacatac 1232761 gaagtgaagg tagacatgca ggcaaaaaca gtcttgtctg ccgatcaaat cagcagcaaa 1232821 gatcaacaaa aaacgccgat tacgaaaaaa gaagccaaaa caattgcaga gcgaaaaacg 1232881 ggcggaacag cggatgacgc agatctcgaa gaaagtgagg gcactctcat ctttgaagta 1232941 gacgttgatc ttcctgataa taaggaagcg acagtgaaaa tcaatgccta cacaggaaag 1233001 gtagctaaca ttgtgtatga agactgacgg tttctcatca aattctcatc ttgctctcgt 1233061 tttcctttca tgttgagtat gtaaactgta ctcatacaaa acaaaggagg gctcacaaat 1233121 gctcaagaaa aaatggatgg tcggtctttt agcagggtgc ctagcggccg gaggattcag 1233181 ctacaacgcg tttgccacag aaaacaatga aaacagacag gcttcttcta agacggatgc 1233241 actcactgaa caagaagcag aagcaattgc taaaacagtt gttgacggca cagtagaaga 1233301 cattgacaga gacctttaca acggcaaaga agtctatgaa gtggagattg aaaaagaagg 1233361 tgaagactac gacgtttatg tagatattca tacaaaacaa gcgcttaatg acccgttaaa 1233421 ggagaaagca gaacaagtcg ccataaccaa agaagaagct gaagaaattg ctttaaagca 1233481 aacaggtgga accgtaacag aaagtaagct tgacgaagat gacggtgctt acatctatga 1233541 aatggaaatc caaacgaagc aaggaactga gacagaattt gaaatttccg caaaagatgg 1233601 acgcattatc aaacaggaga tagatgacta atcaaaaccc ccgctgcagc gggggttttt 1233661 catgataaga aaccttcttt tggacaatct aagtagaaaa ggaggcgaaa cgcatggaaa 1233721 agaaagagga gcaatacatc aatcaggctg aatatgtccc tcatccgacg aaggaaggag 1233781 agtatgcctt atttcttcat gaaacgtatc atttgctttc tgaagatgac gagacacaaa 1233841 caacagaata agggcttagg cccttgtttt gttccgtaat tgtgatgtaa gcgcatttat 1233901 tacttttttg agttgacata gcttgttttt ttctgtaatc tcagtgtgtc aattcaatta 1233961 ggaacttcgt taggtgaggc tcctgtatgg agatacgctg ctgcccaaaa atgtccaaag 1234021 acgccaatgg gtcaacagaa atcatcgaca taaggtgatt tttaatgcag ctggatgctt 1234081 gtcctatgcc atacagtgct aaagctctac gattgaaggc gcccgcacgc tttttttgcc 1234141 gtgcttcttt caccttcaat cccgaaggct ttttttatgc ctttaaaacg aaaccaatca 1234201 aaggaggtgc ggagtatgga ttctccccat tcgagtcaat ctgaagaagt acccatatac 1234261 tatgacagca agacaattga ttacacgatg aggagacgaa ctgccgcacc ttctggcgag 1234321 gccggcacgt ctccgtagag gaggtacgag tcccgatggt tcaaaacatg acctatgacg 1234381 aactcatttt acgcatcatt attttactgc gagacgggaa aatcagggat tttagaagtg 1234441 ttattgatga gcttcagccc tatgacatgg catttatttt taaagaaatg ccggaaaaac 1234501 atcgcgcccg ctatttatct tatttaactg tagacgatat cactgatatg atcggggagc 1234561 tggaacgcga atttcagctt gtcgtcttaa ataaagtcgg aaaaacaaaa gcaacactgg 1234621 cgatgaacaa aatggacaac gatgacctcg ctcaattgct tgaagaaatg gacgaagaac 1234681 tgaaggaaca gcttttatcc agcatggaag cgtcagaatc aaaagctgta cagctcttga 1234741 tgaattaccc ggctgattca gcgggacgca tgatgacaaa ccggtatgtg tggatccctc 1234801 agcattacac ggtaaaagac gcggtcgtca aactgaaaag cttcgctgaa atagctgaat 1234861 cgatcaacta cttatatgtt attaatgaaa gcaaacagct ggttggggtt ctttcctacc 1234921 gcgatttgat tctgggtgaa cctgaagaaa aggtgcagga tttaatgttt acccgcgtca 1234981 tatcagcaga tgctcttcag gaccaggaag aagttgcccg cctgatagaa cgttacgatt 1235041 ttttggcaat accggttgta gaagaaaaca acgtgcttgt cggcattgtg acggttgatg 1235101 atattatcga cgttgttatt cgggaagctg atgaggatta cgaaaaattt gccgcttccg 1235161 gtaaagacat cacctttgac acaaaagctt acgtggcggc ataccggcgt ctgccatggc 1235221 tgattttact cttatttatc ggactgattt caggaagcat tatcagctat tttgaagacg 1235281 cgctgaagca ggttgtcgcg cttgcgtttt tcatgccgat ggtgtcaggg atgacaggaa 1235341 atacgggaac acaatctctt gcggttgtca tcagaggttt gtctaaagaa gaaatgaaca 1235401 aaaaaacgat tgtgcgcctg atcttccggg agttcagaac aagcattttt atcggagcgg 1235461 tttgttctgt gctgattgcg attgtttcta tcatatggca ggggaatgcg cttttgggat 1235521 ttgttgtcgc ctcttcactg ttcttaacct taatcatcgg cacgatgtca ggaacgatta 1235581 tccctattat tttgcacaaa ctgaaagtag acccggcgat tgcttctgga ccgctgatta 1235641 caacgttaaa cgatatttta tctttattaa tctactttgg cattgccact gcattcattc 1235701 actcattata aacgtaaaaa gtccgtctca actgcgagcc ggacttttat tatttaacgg 1235761 tttttgtacc gaaagtgagc attaagctgc ccctccagca tttttttccg cacttgcgga 1235821 tcgtttttta acatctgttc ttttttgcgc atatccttta aaatctctgc cgtctgtacg 1235881 ccgtcttcac gcttattggc gatatccatc agccgctcca catcggcaaa ggagtatttt 1235941 cttgtccccc ttgaagaacg ctgcgggtaa atgagctttc gttcctcata atacctgatc 1236001 tgtcttacgg acaatcctgt caattcactc acaattccga ttgaaatcac ttttttgtct 1236061 ttataagaat gatcttctgt ggtcattttt ccacccctgg atgtcttttg ataatagtat 1236121 ataaaaaaca aagagaaaaa acctgacgct tgtcatattt tctaacatca aatagaagat 1236181 ttttgaaaaa atacggaaga aaaattaaca agaataatgc gtaacaccca agcgcgtttt 1236241 atcctttatg taacgaatca aacgaggagg aaggataatc atggaggaag aaaaagcagt 1236301 ctcactggca aaagaaatta tagagttgga tatcaagcgt gatgaaatgc tggagacgtt 1236361 tatgcagctt gccggagaac aggcttttca attattaaga tcggttcaaa acggacaata 1236421 ccgaaaatct tcgtaaacat aaattcttta cattagattc ataccacgtt catttaaaaa 1236481 gagtatcttt tgtataggat acctcaaaat gaaggaggac gctatgagta atttattgaa 1236541 atccgcttta gaaaaagaac gacgccatta ttctgaaaaa ctctatcaga taggggttta 1236601 taataaagag gtcatgaaca aaatgacgat ttctgagctt cggaaagaat acgcttattt 1236661 ctttcgaagc attacaaatc ataaaaatta tccttataca agataatgta taaggatttt 1236721 tttgctttta gaaggaattt ctcgaattat agcgaatacg tatagtaagg gactgaactc 1236781 ttattatatg taagggtttt cattattttt ttataaaaat cctatatacg aggtagatat 1236841 gatgagatta tcgtttaacg aagaagaagt tgagcgtgcg atgaatttgt acagagtttt 1236901 tgcaagggct ttcaaaagtg tgtccgaaca tagtatccgt gatagcaaag agcacggttt 1236961 taatcccact gaatttgctg tactggaact cctgtacaca agaggcccgc aaaaattaca 1237021 gcaaattggg tcgagacttc tgcttgtaag cggaaacgtc acatatgtta ttgacaaact 1237081 agaaagaaac gggtttttag taagggagca ggacccgaaa gataaacgct ctgtttacgc 1237141 acatttaact gacaagggaa atgagtattt ggataaaatt tatccgattc atgcactgcg 1237201 tattgcgaga gcgttttcag gtctttcgcc tgatgaacag gaccagctga tcgtcctgct 1237261 caagaaagca ggcatacaca gccagcattt gctgtttcgt taactattct acactctcta 1237321 tttcaggaga gtgttttttt gtttccatat gattcttttt aaaacatctt taatcttcct 1237381 atcagacatt tcgccaaggt atccattgac gtgtttttta tactccttca tctgttcgtt 1237441 cgattgaaaa aatgccgcga tatactcttc tgctttctgc atgtcccagt ttctcatatc 1237501 tgtgacgagt ttcctttcat gtagaaggtt taaattcatt tcctcctgtc ccggcagtgc 1237561 atgataaata aataccggaa gccgtttctg taagcattca ctgatggtca cgcctccggg 1237621 tttagtcatg atgcctgtcg cctgttcgta caaacggttc atctctgctt tgctgtgaag 1237681 gtaaggaatc gcctcaatca aggggtggtg taaacttttg acataggagt agagcttttc 1237741 gtttctgccg cataatattt tgtataagat ctttccgcct ggcgacagtt cctgcaccca 1237801 ttttaaaatc ccaccgaccc ccatactgcc ccctgtgatg atgatggtat atggcgggtg 1237861 gtgctgcaag gtatctgctg attccatttc aaaattttgg tgaactggaa tgccggtcaa 1237921 gtatatgttg ttctgatcga taccctctga tattagctgc ttctttactt ccgtgctcgg 1237981 aacaaaatgg taatcaatgt tcttccgtcc ccataattga ttcacgaaaa aatcagtgta 1238041 tacattcaca accgtcagat tcggatattc aggctttagt cggttcagca gataagaagg 1238101 cagcgcatgt gtgcagaagg cgatatcagg ctgtttttct tggaggatgt gcctcatttg 1238161 ctgtgtgaac agccattcgt acatgaaata gcgtttgtca tgctgaaatt ctccgcaggc 1238221 gaggagcctg taaatgccgc tgtacgtttt cgggaaatat tgaatccatt ttaaataagc 1238281 cacggaggac aatttttcta accgcctata cgaatgtgaa aagatatcaa tcttttcagc 1238341 tgccagccct tgagactcta attcagcctg caatgcatca gccacatgat gatggccggt 1238401 ggaaatgctt aaaaaaggaa aaatgagaat gtttttcatg acagtcctcc taaaaaaata 1238461 tggcaactat attttgagga gaacgttcac aaaatataag ggtgtttttg atcataagga 1238521 aggtgaaaag atgaaaactt gtttcctttc catatggaga gtggttgatc cgatttattt 1238581 ctttttttca aggctaagct tgattgacaa cgatcaaaaa agcgtttttc gagtcaggct 1238641 gacgaagtac aaaggacatc atgtcgtgct tagcgacgga acgcatataa gaaaaaatga 1238701 tgtgctcgtt aaaatccacc tgcataacat aaagctgatc agggagctgc aaagcattga 1238761 gagcgcagtc agaaagggaa tcattattta tcagaaagta tatcaatcga tgccgcttct 1238821 tcttgactat atcaacaatc ataaaaaaag cgagaaaatc aaaggaatca ttgggattac 1238881 aatgcttgac aaaggtgtgg aaaggctcgg ctttgatgtg atcaccccgg tgaacccttt 1238941 ttacagatgc tttaaaaaag tgtctcatgt gccgatttta tatttgactt caaagcctgt 1239001 gagcttgcgg catttaccga attcatccta tttgtttatc tcaaaagaaa agctgcagaa 1239061 aacctatcaa aaaaaagact gatgcctcgg tcagcacagt cttttttgat taaatctgat 1239121 gaaatgtcac ttcagggcgg cttccgacac ggatatttac gccggtttgt cccaagccct 1239181 cgctgatata aaatggttta tcgtgatgat aatgaaggcc tttaatcatg ttcattcgca 1239241 cgagctttcc cattttcacc aaatgatacg gttttggcca gtgaatttgc ccgccgtgaa 1239301 aatgccctga cagcaggtaa tcataatgaa catctttcat atccagaata atatttgggt 1239361 catgtgttaa gacaagatga tagccatttt ccagactttg ataagagccg gtgatattac 1239421 tccgattcgt actgtaatca tcaatgccga taatattgac tggtcctgca gccgtctcga 1239481 ttcgaacatg ttcattttgc agcgtgatac agccgttttc ctctaaaact cgcttcaatc 1239541 tctgaaagtc ctcttctttc aatacataat cgtggttacc gaacaccgcg tacattccat 1239601 atgcaggctt tagcttttgc aaggcgttca agtaacctgc cagtttcgga atattacgtt 1239661 tccgatcaag aaaatccccg gtaagagcaa tgatgtccac aggctgatct tttgttaaat 1239721 gatacagctc ctcaggtgag actgaaatgt tttccaagtg aagatcagat aaatgaagga 1239781 tatttaattt ttttctggct ggaaggccgt ctttttggtc gattgaaatg gtgttgactt 1239841 tcacatcttt tgtattgcgg ttcgctttat atagaaatgg cacaaatacg agtatggcca 1239901 atgaaagtaa gattgtaaac aaaatatatc ccctcccttc tatcagtata gtaagtgatc 1239961 aagccctatg gatagcggga attaatgggt agagacaggt tgaaaaacgg attgtcatat 1240021 gatgaatgat ttggaaggga aaagggataa taaattttga cacatgaggc agaacatgcc 1240081 gacggagtca gaataacaaa tggatgtgta agcaatgtta cgattgatga gacaacaaaa 1240141 aaaagaaaca tattatctct ggatcgcatt atttcttctt ttattgtatg tatccccgct 1240201 ttttatttta aaggaagatg cccatatccg ggtccacgat aatttagatt ccaacatcgc 1240261 ttggtacaag gttctggccg atagcggaga aatcgtcggc aaggttgacg ctgccattcc 1240321 gcaaatcatt aacgggctgc cccgggatgc ctttggcacc gagtggagcg gaattgtttg 1240381 gctccatgct ttcttttctt ccatgaccgc ctatgcaata agccagacgg ttacaagagt 1240441 tgtcgctttt tttggaatgt atgtgctgct gaagaaacat ataatcccgg aaccaaaagc 1240501 ggctttcatc cgaattggcg tatcgcttgc atttgcctta acaccgttct ggccttcggg 1240561 aatgctgagt acgcttgggt accctttggc actgtgggct tttttaaata tccgaaaagg 1240621 ggatatctca tggagagagt ggctgacgct gggcttgctc cctctatact caagctttgt 1240681 tctaggcttc ttctttttcc tggcagggat ggcgtgtttt tggctgtatg atgccattac 1240741 aaaaagaaga tggaatttga tgttcttagg cagtattgca tttatgacga gtatctatct 1240801 tttcgttgaa tatcggcttg tctattcgat gctgtttgag cacgcaccga tgcatcgtat 1240861 cgaatttatc tcatctaggc atgacgtttg gcattctctt cgactatcca taaaaaactt 1240921 tgtctatggc cataatcatg tgatgaccgt tcataccgtt gtcatccttc cgatcctgat 1240981 ggtcgtattt gctgctctgc tgttcaaacg aaatcggaca aagccagaaa atgtttatct 1241041 gtttttatgt gtgcttaatt acgggttgtc attatggtat gcgttttggt tcaacaaaat 1241101 ttgggctgtt ccaaagcaga aatttgcttt tttagcagaa tttaattttg cccgttttca 1241161 ttttcttcgg ccgcttgtta tatacgtgag ctttgcgctt gctttatatc tcatttggcg 1241221 gatggggaaa ggatggaaat ggcttgtgta cgccgcagtc gctgcacagc tgatggtgtt 1241281 ggcgcctttt aatgaagaat atacgtatgg tgttcattac aacgcgccga cattcaggga 1241341 gttttatgca tcagagcaat tcaaagagat taaggaatat atcggacgtc cgcaagattc 1241401 gtatagggtg gcgagcatcg gactgcatcc gtctatcgcc caatataacg ggttttatac 1241461 gttagatacg tataacaatc tgtatccgct ctcatataaa tatgaattta gaaaaatcat 1241521 cgaaaaagag ctggaaaaaa attctcggct gaaacaatac tttgatgaat ggggcagccg 1241581 ctgctacctt tttgtcgatg aactcggtaa acgatatgat ttcaaaaaga actcgaagaa 1241641 aacgatcaac aaccttcaat taaatacaga tgtatttaaa aaaatgggtg gacggtacat 1241701 tttttcttca gttccgatca tgaatgctga acaaaaccat ctcgcgctcg taaagacgtt 1241761 tgaccataaa gattccgcct ggcgcattta tttatatgaa acaagataag gaggatatcg 1241821 attgaaacag tcacagccag tattaaccat cgtcgtcccg tgtttcaatg aagaggaagt 1241881 gtttcaagaa acaagccatc agctgacaga ggttgtagat gatttaattg aagaaaaatt 1241941 aattgctgaa gacagtaaaa ttctgtttgt cgatgatggc agcaaagacc gcacttgggc 1242001 tttgattgct atggagagca taagaaacaa gaaggttacc ggcttaaaat tagcctgcaa 1242061 tgtcggccac caaaaagcgc ttttagccgg attgcataaa gcgaagaata ggtcagactg 1242121 cgtcatttcg atcgatgctg atcttcagga cgacatctct gtgatccggg attttatgct 1242181 gaaatatcat gagggctgcg agatcgttta cggtgtacgc cggagcagaa aaaccgatac 1242241 ctttttcaag cgcacgaccg cgttagggtt ttatcgtctc atgaataaac ttgggattaa 1242301 attaatttat aatcatgctg attttcgttt aatgaataaa aggtcccttg aagagcttga 1242361 gcgttatccg gaagcgaatc tgtttttaag aggtattgtc cccatgatcg gctttaaatc 1242421 ggccgaagtt ttgtatgacc gcaaggaacg ctttgccggc aaaacgaaat atccgctgaa 1242481 aaagatgcta tccttcgctt ttaacgggat tacttcattc agtgtcgcac caattcgatt 1242541 ctttacgctt ttagggtttg ttttgttttt cctcagcgct gtggcaggga ttggcgcgtt 1242601 tattcaaaag ctgctcggcc atacgaatgc aggctgggcg tctcttatca tatccatttg 1242661 gtttttgggc gggctgcaat tgatgggaat tggaatcatc ggagagtata ttggaacgat 1242721 tttttctgaa gtgaaaagac ggccgaaata cgcgattgat attgatttgt ataatgaaca 1242781 gctgagcccg cttcagcgcc aggaaaaaga gcggttagaa aaaaagtaca gttaaacacg 1242841 gaaagagctg acttcattag tcagctcttt ttcttcaact gatgcaatat agcgctaagc 1242901 ggttcgtctt gcgggttgcg gtaaaaatca aaaaatgggc agccctgctt cttaattcga 1242961 tcgatgaccg tatcaattgt aaacagagcg ggtgttaaag atgattgcac ctcatgccag 1243021 tagagcgggg ctgcaacagt cccaagctca tttcctctcg ttgaataggg acagataatc 1243081 gtttttcctt ctgcatgctg caaataatca agatacaatt tgcagtgtct gtttttaatc 1243141 aagcgttcag tggtaaagag ctcgggaaat gcattggtgc agtactctgc gatcagctgc 1243201 gtaaattggc gtgtttcttc atacgtaaat gcctcgggag acaagggaat ataaagctgg 1243261 atgcctttgt tgccggacag cttcgggtac gatgtgatgc caaaggaatc caacagccgc 1243321 ttcagttcat ttgcggcctg cacggccata agaaagtcat ctcgcgaagg cgggtctaaa 1243381 tcaatgacaa tctcagccgg acgcctgctt ttaatggttt gaaaaggaac gtgaaactcc 1243441 aaagcaagct ggttgcaaag ccatagcaat gtagacatat cctcacagac aatatgttca 1243501 tggcttccat catagaaaga ctgaacaaaa tccggcgcat agtccggctt gtttttttgg 1243561 aaaaatgatt cgctcctaga tccatgcgga tagcggatga cggtgacagc ccggtttttc 1243621 agaaatggga gcaggtagtc actgacttca atcatatact gaataaaatc ttcttttgtt 1243681 tttttattct tttcaaatat gattttatcc aggcttgtga actggagctt tgggtgaacc 1243741 ggtttggagt gtcgtatgac ttgcgcatac gtgcattcgg tccagtccat ttggaattcg 1243801 aaaccgataa acgatacctc tcttaatgtg ccttggagaa ttgttaagta ttgaacagct 1243861 gcacaaatcg aaggttcaag cgtaaattcg cctgagggtg tttgatgtcc gtgctgttcc 1243921 ataatctcgc gtatagcgct tttttcctca tcacgcattc cgtgcgagac agaggcaatc 1243981 ggtgtcatta ttccgttttt taacaccgat accgtcagaa acccgttgtt agggttgaac 1244041 cctgttatgc aaacataagc ttgtttaaag tttttatatt tgagccaatc ggacgaccgc 1244101 ttcttttcaa gccatttgct gtttgttttc ttcgctacaa ttccttctcc gtcatatttt 1244161 attaccatct cccagagttg atcaaaatga tcataacagg gaatggattg aatggtttct 1244221 tttgcgtaag gatctggaga tgcaggaagc tttgctgcgg atatgagttc acgcagcgat 1244281 tttttgcggt ccaaatacga aagaagcgtt acatcttctc cgcttcgctc taacaaatca 1244341 aaggcgagaa agcagcacgg ccgcgcgttt gccgattcct gaatcttgtc tggccttttc 1244401 aaacgccccc gcacttgaag gtgttcaaaa tctgcacgac agggattcac caaacatacg 1244461 atttcaccgt caagtgtcag cggaagctct ttttctaggt gctgaaaggc agttttggcg 1244521 aattgtgtga tttcagggaa ggtgctgctg agctccacac catttctgct ggttaaggtc 1244581 acacctgaag aatggatgcg gagaatacag cggtacccat catattttac ttcgtaacgc 1244641 cattctgctc cgattggcgg tgacgaagtt aagaccggct gcatggtaaa cgccatgcgc 1244701 tatgatgtgc cggaggcttt ttttctagtt gttttttgtt ttttatctcc ggctcctttc 1244761 ggttcagcgg cttgtgcagg tgcggcagcc ggtgtctccc ggttcggcct tctggttctg 1244821 tcgatgctgg cttgcagagc gcttaccagg tcaatgacat cttcacgagg tggcgcttta 1244881 tcaggagtga cagccgtttc tttattttct agcttgtcgt tgactctttg cagcagcgcc 1244941 tgtcggtacg tgtcttcata tttctcaggc tcaaacttag cagtcagttc atctattaat 1245001 gtgatagcag tttgcagttc cttatcgttt acattcgatt gatcaggtac acctgggact 1245061 tgagcggcgc ttctgacctc atcgggataa tggatagact ccatgacgat acaattttca 1245121 taaacgcgga gaatcgccag ctgctgcttt gacctgattg tcatattggc gataccgatc 1245181 tttccggttg agcgcagcgc ctcacgcagc agggtatagg ccttcgtccc attatccccg 1245241 gggccgacaa agtaggagcg gttaaaataa atcggatcaa tttcctgaag ctgaacaaag 1245301 tcaacaatct caactgcttt ctcctcatgc tcctgtttta agctttttaa atcttcgtct 1245361 gtcagcacta catattttcc ttttacatat tcatatccct tcacaatttc atcaggacta 1245421 agagtttttt cgcaatttgt gcaaactttc tcgtatttga ttggtgcgtg atcctcttta 1245481 tggaggctgc gcagtttaat atctttatct tctgtggccg catatagctt gatggggatg 1245541 tttactaatc cgaagctgat cgatcccttc cacattgtat gcatatcgat aaaccccttt 1245601 ttttctttag tgtgaagaga aggagtacga ttcatgtgta gtaacttatg ggtgaaaaaa 1245661 agccggcgct gttattgcga cggctgttca ataatgaatt gttcgaattg ttccggaggt 1245721 attggcctgc tgaaaaagaa gccctgcaaa tggtcgcagc ctttttcaaa aagaagctgc 1245781 ttttgagctg cattttccac accttcggca atcacctgca aagacagctg atgccccatg 1245841 gcaataatag ctccggtaat ttgctctgat ttaggatggg tctgaatatc gtcaataaat 1245901 gatttgtcaa tcttcagcct gtgaatcggg aagtccttca aatagctaag agagctgtga 1245961 ccagtaccga aatcgtcaat actgattctg attcctaatt ctgttaggga tgacaaaacc 1246021 tttttggagt gattgagatt gtccattgtc atgctttccg tcacctccac ttcaagaagc 1246081 tgcggaggaa gctggtactt attaagcgta tccttgatga ggggaatcag atctttagat 1246141 tgaaactgtc tggcggaaat attaatggcg acagaaagat catagccttt gtcatgccaa 1246201 atccttgcct gcttgcatgc ttcatctata atccactttc cgatatcaat aataagtccc 1246261 gtttcttctg caacaccgat gaattctccg ggcggacgca gttgcccgtc tggtgtcaca 1246321 aggcgtatca gtgcttctgc tcctgtcatt ttttgttttt tcacactgaa ttgcggctga 1246381 taatgcaaga caaatctatc gttttcgatt gcttctctga gtaccatctc ttggttaagc 1246441 ttaacggttt ctttgttgcc gattgaaaaa gaatagtatc tgtatttgct tttgtttcgt 1246501 tctttagccg catacatcgc catatcagcc tttttcatca attcaaggcc atccgtcccg 1246561 tcttttggag atatcgcaat cccgatactg acagatgtga caagggtgtg atcttgaatt 1246621 ttgaaaggtt ttttgaattt ttggataatt tttcttgcta aaacatctgc ttcgcctgtt 1246681 cctgtattgg cgtctgttaa tataataata aattcatcac cgccaagacg ggcgataaat 1246741 ccgttatcag ggactacaga tgacaggcgt ttagctgcaa actgaagcaa ttgatcaccg 1246801 acattatgcc ctaatgcatc gttaatcact ttaaaccggt ttaagtcaag aaagaataca 1246861 acagtgttat aatgcaagga atgctcgcga ttcagcacct ttgttagatg agagatggca 1246921 tgccttctgt taggtaagtc tgtaagcgaa tcataatgag ccattctatg gatttctttt 1246981 tctgctttgt actgcttcgt catgtcttta caaatgacat aaatgctgtc tagttcctga 1247041 ttgacctcaa caggtataag cgtaatattt aagtgaaact ggcctttttc agtgataaga 1247101 tcgctatcgc tgttcatcgc ttgtttatct tttttaactt gctcaaaaag gcgcttaacc 1247161 ttcagtgatg tgtaattcct ccagtcatgc atgctgaagc caaatttgct gatcatttcc 1247221 tcaccagcgt gattggaaga tattatgtct ccttctaatg ataaaataaa aattgcatca 1247281 atattgtgga cgattaaaga ctgaaatcgc tgttcgttat cctttatgcg ttcgctctgt 1247341 ttaataaact ttcgatctgc atgggaactg aataacaata acgtttggat acaaaaaata 1247401 attaaagtaa caaaaattga ccaatgaaac gtttgcacct ccatatggct tccgggcgga 1247461 gccatgtcct tatggaaagt tgccgcaagc atccctgtgt agtgcatgcc cgaaatccca 1247521 atgcccatta caattgaact gacgccttta tagaatataa gatgctcaga atgttttttt 1247581 acggccaagt caaagaatat ttttaacgag acgaaagagg ctgcaatcgc aatgataatt 1247641 gaaactgtaa ataaaatagg ttcgtaaata atcattaccc gggaaatggc agacattccg 1247701 atatagtgca tagaagcaat agatgcgcca agcacaactg atccggtaag cagtctgtaa 1247761 tatgtaagaa tgtgccggct gacaaaatat aatgacacaa atgatcccga aacagatgcg 1247821 ccaatggctg ccattaaagg catgaattca tattccatcg gcatttccat atggacggcc 1247881 atcatcccta caaaatgcat tgaccaaata ccgaatccca taataagtga gccgccgatc 1247941 agccaaattt tactttttaa gcctgtattg atggtgactt tccttgaaag ttcaagggaa 1248001 atatacgagg cggtacaggc aattagaata gataaacata tgagagtcgt attatatgta 1248061 acgtgtattt ccaaatggag attccccccg tatcgtgtgt tccagtcttg ttgactctct 1248121 ttattatcgg ctgcttaacc gcagagtttc agccttcaaa acgatagaaa tacgagggag 1248181 atctattttt agttcaactg accgtgaaaa atgtgttaaa atcatcttga tgttttccga 1248241 aaagagaaaa atgtatgata cataaacatg aaacaaggga gttggtggct atcgaagagc 1248301 tggttatgtc atggattgaa gcatttaaaa gcttatctta ttttggaata tttctagcgc 1248361 tcagcattga gtttattccg gccgaagtcg tcttgccgct tgcgggctat tgggtatcta 1248421 aaggcgatat gacacttgct ggcgttgttt tggcaggatc gcttggagga gtggccggtc 1248481 cgcttacgct gtattggata ggccggtacg gaggaaggcc gtttcttgaa cgttttggga 1248541 agtatctctt tattaaacct gaagcgcttg ataagtcaga taattttttc aaaaaacatg 1248601 ggggctttgt cgccttcagc ggccgtttct tgcctggtat caggacattg atttccatac 1248661 cgtgcggaat tgcaaaaatg aatgtttggg tgttttcgct ttatacattc attgctatgc 1248721 ttccgattac atttgtatat gtttatctcg gtgtgaagct cggtgaaaat tggaaggcag 1248781 tcggctctat tcttgatcaa tatatgcttc cgatcgggat agcgattttg gcgctgttcc 1248841 tgctctactt actgatgaaa aagaggaaga aacgcacgca ctccgaacaa ttatctgtat 1248901 ttttgaaaaa taaacgttga caaatcactg cgctgcgcat attattgacg tataaaatca 1248961 tatttcttga aatcccaaag gggagtagcg tccggaatgt attccggaaa caaagtcgtc 1249021 atttcatgga ttgtatccat cggctttgtt ggcatgcctg aattcatgtc tagcaagacc 1249081 tttgccttat gtcggcaaag gtcttttttg catggtccgg ccggcataag atcggatgaa 1249141 gagaaagaaa acaacttttt tgggagggta tcatttatgg atgcagcatt attattagag 1249201 tatggttggg ttcttctcgt cttgatcggg ctggaaggga ttttagccgc cgataacgcg 1249261 ctggttatgg cggtaatggt aaaacatttg ccggaggaaa aaagaaaaaa agcgttattt 1249321 tatggattgg caggggcttt tgttctgcga tttggctctt tatttgcaat ttctttcttg 1249381 gtcaacgtat ggcaggttca agcgattggc gcgatctatt tgctgtatat ctcagcaagc 1249441 cacttattga aaagatatgt atttaagaaa gaagacacac ataaagagac gaagcaaagc 1249501 ggtttttggc cgactgtttt aaaagttgaa ctggcagata tcgcgtttgc tgttgattcc 1249561 atcttagcag cagtagcgct ggcggttaca cttcctggga catcactccc gaagatcggc 1249621 ggacttgacg gaggacaatt tctcgtcatt ttggccggcg gtatcatcgg actggtgatc 1249681 atgcggtttg cggcttccat gtttgtgaag ttattaaagg aacgtccaag cctagaaaca 1249741 gcagcctttg tgattgtcgg ctgggtcgga gtgaagcttg ctttatatac gcttgcccat 1249801 cgcgacatag cggttgtttc tgagcacttt atccattctg gaacatggaa gctgatattc 1249861 tggggtgtct tagcagcaat cgcggtttgc ggctggttta tgtcaggtgg gaaaaaacag 1249921 ccggagggtg cacaaaacga acaaaaaaac agcacccgtg aacgggcgta atctgaaaga 1249981 ctctgcttaa aagcagagtc tttttgtgtt tgaagcgttt tcataagcga aataaaataa 1250041 catttttata acatctttgt tacaaaaaac acgcataaaa cccccttaat tctttagaaa 1250101 ggcacgaaat catgtataga acgtcagaat ggtttgtcat aattgagaca ttggaaatca 1250161 atatttcttt ttctcctttg cgaatcccta tcaaattagc tatcattaat gagtagttat 1250221 agggaggaac tgaggtgaaa ccagtgctta gccttttgtt taaattggga aaaaagaagc 1250281 aaacacttga aaaagctgtt gagagtatac aaaaaggcaa taaagatctg caaaatgaat 1250341 taatacagca atataagcca tttatcgcaa agacggtttc atccgtttgt aaacgatata 1250401 tagatgaaaa agacgatgag ttcagtattg gactgatcgc gtttaatgaa gctatagaaa 1250461 aatattcacc tgaaaaagga aattctctgc tcgcatttgc tgagcttatt ataaaaagaa 1250521 aagtcattga ttacattaga aaagaagcca gaagcgcaca aaatataaat atcgatttac 1250581 aggaaggaga cgatcaggag tcatcacaaa gcctgattga agccgagctt tccattgatg 1250641 aataccgccg tcagattgaa caggagcaga ggcgggagga aatcctctat tttcaaaagc 1250701 agctcaagga ttatggttta tcgtttaaag aactgcttga aaattctcca aaacacacgg 1250761 atgcaaggca aaacgccata aaggtggcaa tgacgcttgt tgaacatgaa gaattggccg 1250821 ctatcctgta tacaaagaag cagcttccgg tcaaacagct tgaacagctt gtctctgtaa 1250881 gccgaaaaac gattgagaga aacagaaaat atattattgc gatgtgtatt atcattacgg 1250941 gtgattatat ttatttaaaa gattatctta aaggggtgct gcactcatga gaagagggat 1251001 tatagtagag aaaaataaaa aattcgtcac gttgctgacc cctgacggac aatttttaaa 1251061 agccaaaaat gatcgacaca gctatgaaat cggagaagaa atcatgcttc cgagtgaaac 1251121 acgcatgggc agaagggcca gcttttttga tttttttaaa ctgcgccctt tcaaaatggg 1251181 gatttttacg atgactgcta ttatgctctt tatttttata gttctccccg ttttttctaa 1251241 taataaggcc tatgcgtata tgacaatcga tatcaatcca agcgtcgaaa tggcgttaaa 1251301 cagcgattat gaagtgattg aactgacgcc tctaaacgat gagggacaga aagtcgtgaa 1251361 tgatatagat gattgggaga agactgattt taaaaaggtg attgacgata ttataaccga 1251421 ctgcagtgaa cacgggtatg taaaaaaatc gaaagaaata ttgatttcca ctgtttatga 1251481 aaacacagaa gacaatacat ataaaaaggc tgtgaaaaaa cagctgaatg atgtgactga 1251541 aaaatataaa acgacatacc gcatggaatc tctcgagtca gatatgcaaa cgagggaaaa 1251601 agcgaagaaa gaaggcgtct caacaggcag ctacatcaaa tcaaatgaaa agaatgacaa 1251661 taaagatata aaagatgact ccagcaaacc atccggggaa gaggatcaaa agagtgatga 1251721 aaatgaggat gaaaacaccg atcaaactga cacccaggac agcaagcaag gagataatga 1251781 acagctgaat gatgcggatt ccggagacca gaaagaagag aaagcggatg accagattga 1251841 tgatagtgac aaagataaaa aaataaagga atcagatgaa aacacaaata ccgaaaaaga 1251901 tggggaccat gagcaaaccc caatacaaga tcctcaagat aaaggaaatg aaaataacgg 1251961 cgctgacaag ggccaaagcc aatatcacag ggactggaac aatggtgaac aaggcaagaa 1252021 ccgttcttcg tccagaaggg ataacgcttc agaccgacgt aatccaaacg gctacagcag 1252081 tgataatcat tcagctaaaa atgaagattc gccgagtgcc cccggcgaat aaagacctga 1252141 atttatttag ttgtgccatt taattgtgat tgtgcttgct gtaccagccg ctttgtcatt 1252201 tctccgccta cagagccgtt agcgcgtgcg actgtatcag aaccaaggtt cacaccgaat 1252261 tcttgagcca cttcgagttt aaattggtct agtgcctgct ccacccctgg aacaacgagt 1252321 ttatttctgc tcgccatctt tttcatctcc tttttcgata aagaaattct taacgcgtat 1252381 ttagtttgaa atatacgggg tttatttatg ctggcaattg ttgtggagaa aaataaaacc 1252441 ccggcctctg agccggggtg gcgcagacta tagaatgtct gctgtcattt tatgtgcggt 1252501 tgcctgaata tggaatgtca aaatggagag gactgtaatg gcgataatct gtctgatttt 1252561 aagccattgg ctgtcattca gttcttcaaa acggtgacgg agacgctctg tctcctgttc 1252621 ggcgatctcc tgcagatttg attctttcat agaaggagta tcttggtgat ggatggcatc 1252681 aagcacatat gcgcagcttt cataataagc aatcgggctg atgacatcat cagatctgtc 1252741 tgagattgtg ttaaaggcca cttttaaaat agcccgtatg tgttcaaagt cataaatgga 1252801 ttttaaatca cgtacaatta aaagaataac tgcctgttca attgagtatt ttttgcccag 1252861 ctcagggtgt ccgatcagat ctttgatatc acgctttacc cagttttgaa tcgcggttga 1252921 ctttaacgaa gtcagctcgc ataagttgcc aagctctacg atttcatttg tagacagacc 1252981 gtattctttt ttctgttttt ttcgttcgta tcttgtaaga aattcaggaa tttctagatg 1253041 attggctgct ttttctgctg acatgttcgc tgattggacg agaatgtcga gcgggctatg 1253101 ttctccttgt ccttttaggg aatagagcag ccgcaccata tcggttcgag agagtttaaa 1253161 aatgttcatt gttcacctct ttaaacaatt tgacgcggat ataggtctat gtataagttc 1253221 aaaattcaag cgtcagcaaa ttacattaac atcatacgtc gaattccttg cattttcaaa 1253281 tggatgtttt ataatttaaa tatacgggtt cttttgaact taaaataacg gaggttgtta 1253341 tggcgaaaag aatttttctg tttattctaa cgaatatttt ggtgcttaca acaatcggga 1253401 tcgttttgtc tgttttaagc tctgttacag gagtcgggac gtactttaca gctgatggcg 1253461 gtatcgatcc aatggcgctt cttgtgttca gtttagtcgt tggatttgtc ggttccttta 1253521 cgtctcttgc gatatccaga tggatggcaa agacgatgat gggcgtcaga gtgctgaatc 1253581 cgaaaaaaca ctcgctcagc tatgaggaac agcaattggt tgatcgtgtt cacagattaa 1253641 gccgctctgc cggtttaacg aaaatgccgg aagtcgggat ttaccgttca cctgaagtaa 1253701 acgcgtttgc gactggaccg tcaaaacgcc gttcacttgt cgcagtatcg tcagggctgc 1253761 tggagcagat ggatgacgca gcagttgaag gtgtgcttgc ccacgaggtc gcgcatatca 1253821 caaatggtga tatggtaaca atgacgcttt tacaaggtat cgttaatacc tttgtcgtct 1253881 ttttatcgcg tatcgccgct tggatagcaa gccgttttgt caaagaagat ctagcgccga 1253941 tcgttcattt tattgcaatg attatttttc agattgtctt ttcgatactt ggcagcctgg 1254001 ttgtgtttgc gtattcacgc catcgtgaat tccatgctga caggggagga gcggatcttg 1254061 ccggcaagga caagatgatt catgcgctgc ggacgcttaa aagctattct tcccggattt 1254121 tggaagacga tcagacagct gtccaaacgt taaagattaa tggcaagaag cgctcttcac 1254181 ttttctctac tcatcctgat ttagatgagc gaatcagacg gctggaagct aaataataca 1254241 aacacattgt tcctctgaga gaattctcag aggtttttta ttttatccat tgactaaaat 1254301 cataaaaaaa taagcaagtt aagaaaatgt ttcgtaaaag cctttaaaaa tggacctaat 1254361 atctttagaa taattaccgt acttaaaaag agaggcagaa ggattttaca tgagattaaa 1254421 gtttggaaaa ttgatacagg ccttgtcacc ggcccagctg atcgcattat attattttct 1254481 tgcagttact gtggccgtta tattgctgag tttgccggcg gcccataaac cgggggcgga 1254541 ttggacgttt attgatgcgc tttttacagc tgtcagttca gtcagtgtaa cggggctgac 1254601 agttgttgat acagctgata cattcagcac aatagggatt tttatattag catttgttct 1254661 gcaatttggc ggaatcggaa ttatgacgct cggaacgttc atttggctga tcatgggaaa 1254721 acgaatcggg ctgaaagaac ggaagctgat tatggttgat caaaaccaat cccagttttc 1254781 aggaattgtc aatctgatga agcaggtact gtttctgatc ttgtggattg aattttttgg 1254841 cgggctgata ctcggcacat atttcttaac ctactatgac tcctatcagg aagcctattt 1254901 acacggattt tttgccagta tcagtgcaac gacaaacggc ggatttgata ttaccggtaa 1254961 ttcgatgatt ccatttcgcc acgattactt tgtgcagttt attacaatgc ttttaattat 1255021 atttggagcg attggatttc ccgtgcttgt tgaagtaaag gatttcctgt tttcaaagca 1255081 tcggcgttat ccatttacgc tttttacaaa gatcacgacg attacgttcg gctcacttgt 1255141 cttgtttgga gccattggca tctttgccct ggaagcaaac catgcgttcg caggaaaatc 1255201 atggcatgat attttgtttt tgtccctgtt tcaatcaacg gcaacccgaa gcggggggct 1255261 ggcaacaatc gatatcagcc aattatcaga ttccacactc ttttttattt gtgcgctgat 1255321 gtttattgga gcgtcgccaa gctcagtcgg gggaggcata aggacaacga cttttgcttt 1255381 gaaccttctt gcgctgtttc attttgcccg cggcaataag gccgtaaagg tattcaaacg 1255441 ggagcttcac cctgctgact tgatgaagtc gcttgttgtc acgatgatgg cgatcctgct 1255501 cgtttttggc gcgacactca ttctgaccat tacagaaaaa cattccctgc tggagctttt 1255561 gtttgaagtg tgctcggcat tcggtacaac cggcctatcg cttggaatta cggcagattt 1255621 gagcagtgtt ggaaaatgcg tcattatgat tgtcatgttt atcgggcgaa tcggcatctt 1255681 gaccttcctg tatctgatcg gaagaaagga aattgaagcg aattatcact atccgaagga 1255741 aagagtgatt atcggatagg caaaacaccg catattttgc ggtgtttttt gattaccaaa 1255801 aaaaagatgt gtgcctcctg ttcagttgga gaacctaact ccgacaggtg caatttacgc 1255861 tcctgcatct taaaatgtct gaaaattggc gaggaggatt cgtatgaagc gtaaagctga 1255921 agtgaatgaa gccattaaaa ataacaatac acctaccgag agcatggacc ccaattcata 1255981 taagacacaa tatcatgacg accccaattt tagaggggca aaccgcaatt ccaaacaggg 1256041 ccagcaggga ggcatgtaat tgtgaagaaa aaccgtcata gcagagacat gcaaaatcat 1256101 aaaaagccta tgaataaaaa ggtgctggag gaagaattct caagtgaact cggggattac 1256161 aatgccggaa agatcatcga aacgctggaa gtcaccaagc ctgaaaagaa aaaagaaaaa 1256221 aacaaaaaac aacaataaaa aagacctctt aggcggcgtc ccgcttaaga ggtgcttttt 1256281 ctattttaaa taagcatttt tgcccgttcc tctgacaaat tgcaataagc ttgtcatcct 1256341 cagctcaatg aatggctgag cgactgtctt aacaaagttg ctggagagga ctgatgtcag 1256401 ggctgctgtt aaaagcaaga ggatcactaa gctttgatag tcagtaagcc aatcctcaag 1256461 cccgacctgc cgtaatgtct taataataaa cccgtgaagc agatacacgt aaaatgtccg 1256521 ggttccccat ttggtaaaga aataccgttt ttgcggaacg agcgctaaaa agctgaaggt 1256581 tgccccaaag gcgagtacat accagccgat tcgggatagt ccgcttacca gggtaacgtc 1256641 tccaaatgaa gaatacggtt ttgaaccaaa cagaaaagaa tagtcaaaat cgatgcccca 1256701 gcagatgacg aatactgcgg caagcactcc gagcgcaatt tgtttgccgc gttttgatct 1256761 caataaatca aaatgatgtt tatttaaata aaaaccgaca aggaacatcg gtaagaatac 1256821 gaatgtccgt gacaagctca gcgtgctgct gacaaagtcc agataaccga tcagcacggc 1256881 gattccgcag ctgacaaaca gcgcccactg ctttgaaagc tttgaaaaag gatataggag 1256941 caggttccaa aagaataagc ttacaagaaa ccataacgac cattgcggat caatcgggtt 1257001 cacatttgcc atgctttcat cttgcataat gtaataaaag acggaataaa taatttggaa 1257061 aatcaaatac ggaataatca gcttgaccgc cagctttttt acatatcccg cccgtttaaa 1257121 gcctttcgcg aaataaccgg atacaagaat aaatgcaggc atatggaatg tgtaaatgaa 1257181 cttgtagagg tagagcataa aatgattatc attaataaag gaacgaagga tatgaccgaa 1257241 tacaacaagg aatatcaata aaaattttgc gttatcgaaa taactgtccc gcgatttact 1257301 catagcatca ccttctcttt catcagtcac taagagatta ttccctgctg gtacatattt 1257361 taaaataaaa gatgaaaaag gaatctaaaa aaatgctgat tgttaggtcg atgtaaagtg 1257421 acggtaagga tcgtagaaaa tgtcttcgta atgtaatgac gctgaaattt tctgaaattt 1257481 atagggcaaa tgaaggaagt tcccgcattt tgtagaaata ttgagggata ggttttgaag 1257541 aaggagtgta catgcatgga aactcttggt gtccagacaa actcggagct gcgagaggaa 1257601 ctgaatcgcc tcaaagaaga aaacgcgcga ctgaaaaagg aattgaatca gcatcaagtg 1257661 attgtcaaca atacgctcga tgctattttt atttgtgata acgaaatgcg gattgttcag 1257721 gcaaatgaag caacagaaag gatgcttcaa gttgactcgg aagatttgaa aaagcgttct 1257781 gttttggatt ttttgttttc aatcccaaag gatgaactga atctttccgt aaagaagttt 1257841 tttaaaaaag gctttctgtg gaaggaggtt ccgatcaggc ttgattgcgg ggcaacaaaa 1257901 tacatagagt ttctggccaa aagaggtatt ggtgaggatt tcttttttgt tgtcatgagg 1257961 gacatatctt ctaagaagat tctggagcgg gaattctcta tgaatgaaca gctttttaag 1258021 gacttgtttg acagagcagt tgacggaatc gtcctgtttg ataaagatgg cggttttatt 1258081 gatgcaaatt tgtccttttg taaaagcttt gaaatcaatc ataatgagct gtctcattta 1258141 tctttgtatg agttcataga cagcggctca cgaaaagatt tcgacaatat ctggaaggcg 1258201 ctcaaccgca agggaaaagc gaagggggag ctgcctgtca agcttcgttc aggagttcaa 1258261 aaactatttg aattcacgat tacatcaaac atcatcagcg gtttttatat gtccattatg 1258321 agggatatca cagagaagcg gtctatggag ctgcagctct ttaaaagtga ggagcgcttc 1258381 agagaaatct ttgaaaatgc aatggacgcc atcatcatct ggtcgaatga cggaagaatc 1258441 gtaaaagcga atcaatcagc ctgtaaaatt tttgagctgc cgatgaattt gctgttgaaa 1258501 agaaagctgt gtgattttct cgttgactcg cagcagaaat acagcataac gaagaggaaa 1258561 tacgcaaaat acggagagat cagagaagag ctgctgtttc aaatggggaa cggccaattc 1258621 aaagagcttg aatttacttc aaaacggaca atccttgaaa atcagcattt gacgatctta 1258681 agaaatgtaa gcgacagaaa gcggatggaa aaggagcttc gggaaagcga gctgaaattc 1258741 agaaaagtgt tcaacggatc aatggacggc aatgtattgt tcgacaatca atacaggatc 1258801 atcgacgcca acccgttagc aagccatatt ttgggcctgt cacatgaaga gatcaaacag 1258861 cacagcctgt tagatattat ttctgcttat gaaatagaaa atttggcatc accggcaagg 1258921 cagattaatt ttgatgaaat ggacaacgaa attccatttt tgctgagcag cggtgataac 1258981 agaaaactcg aattctcatt taaacggaat attattcaaa atatgaactt ggctatcttt 1259041 aaagacgtaa cagagcgaaa agaattggag gagcgcctgc gcaaatcaga tacccttcat 1259101 gttgtcggcg aactcgcagc cggtattgct catgaaatca gaaatccgat gactgctctt 1259161 aaaggcttca ttcagcttct gaaagggagt gtcgagggag actacgccct ttacttcaac 1259221 gtgatcacct cagaactaaa gcgcatcgaa tccatcatca ccgaattctt gattttagcc 1259281 aagccccagg ccattatgta tgaggaaaaa catgttaccc aaattatgag ggacacgata 1259341 gaccttctaa atgcgcaagc caatctcagc aatgtacaaa tgcaacttga tttaattgac 1259401 gacattcccc cgatttactg tgaaccgaat cagctgaaac aggtttttat caatatatta 1259461 aaaaacgcca tcgaagtgat gcctgacggc ggaaatattt ttgtaacgat aaaggcattg 1259521 gatcaagatc atgttctaat ctccttaaaa gacgagggaa tcggaatgac agaagataaa 1259581 ttaaagcgac ttggtgaacc gttttatacg acaaaggaac ggggaactgg acttgggctt 1259641 atggtaagct ataaaattat tgaagaacat caaggcgaga ttatggtaga aagtgaagaa 1259701 gggaagggca ccgttttcca tattacgctt cctgtcagac agaatgctga agaaagaagg 1259761 aatgatgaat gaactactat acgacagccg aaacgccgct cggtgaactt atcattgccg 1259821 aagaggagga ccggatcact cgtctatttc tcagtcagga agattgggtg gattggaaag 1259881 aaacggttca gaatactgag cataaggaaa cacctaatct tgcagaagcg aaacaacagc 1259941 ttcaagaata tttcgcaggc gaaaggaaga cattctccct gccgctcagc caaaagggca 1260001 ctccttttca gcaaaaagtg tggcaagcgc tggagaggat tccatatggc gaatcccgaa 1260061 gctatgcgga tattgccgct gctgtcggca gtccgaaagc ggtgcgcgct gtcgggcagg 1260121 ctaataaacg taacgacctg ccgatttttg tcccgtgcca cagagtgatc ggcaaaaaca 1260181 gtgcgttaac aggatacgcc ggaagcaaaa cggagatcaa agcatttttg ctaaacatcg 1260241 agcgaatctc ctataaagaa aaataaaaca tatggcacgt tccctttttt cacggccgac 1260301 atatcatttt attaagttaa aaaagttggt ctgatgaaaa aggaggacaa agcaattgaa 1260361 gccgagccgc tctgagaaac ttgccgtttt tgccgaactg tttgtgaaac tgcatatctt 1260421 atcaagcgct caaaaagatg aaatcatcaa tgttaacaaa aagaaacaaa aaaaccgctg 1260481 actcggctcc aaatgagcaa agtccagcgg ttttttaatg caccttttct cctttaaaca 1260541 gctgttcaat ctcttcttca tagtttccgg tcataatccc tttttctgtg atgattcctg 1260601 aaatgagatc atgaggtgta atgtcgaaag cgggattaaa gacaggcaca ttggatggag 1260661 cggtccgaac tccggaaatc tgcctgactt cctcgggatc tcgttcctct atcgggatat 1260721 cagcgccgca tttgaccttt gtatcaaatg tagataaagg tgcggcgaca aaaaacggaa 1260781 tatcaaaggc gtttgctaaa atagcaagac cgtatgtgcc gattttattt gccgtatcac 1260841 cgttctttgc aattcggtcg gctccgacga taacagcgga aatttgtttt tccttcatcg 1260901 tatgggcggc catgctgtct gtgatcagag tgacatcaat gcccccctgc atcagctccc 1260961 aagcagtaag gcgtgaacct tgcaggacag gccttgtttc acaggcataa atgtgtaatc 1261021 ccaaatcttt ttgtttggcc aagtaaaacg gagctagcgc cgttccatag cggcttgtcg 1261081 cgattgagcc ggcattgcag atcgtcatga tcctgtcgcc ttttttgaaa agctgcaggg 1261141 cgttttggcc gatcaaccgg cacgtttcct catcctcgac ctgaatctga atggcttcat 1261201 ggacaaggtt tgtttttgct tcatttacgg aaatcgcgtt ttcgaccgaa tgactcagtc 1261261 tctcaagcgc ccatgacaaa ttaatggcgg taggccgtga gctgtttaaa tattgtttga 1261321 tgtcttccag tctgcggcgg aattccgtga cattgtctgt ttcaatgtct ttggcagcaa 1261381 gcgccagtcc gaaggcagct gtaatgccga tcgccggagc gccccttact ttgagcgtga 1261441 caatcgcatc aaatacatcc tctttcgtcg tcagctccaa atattccgtc tcatcaggaa 1261501 gcttttgctg atttaaaatg gtaatagctg tttctttcca ttcaacagaa cgtggaacag 1261561 caaatgaatg ggtcatgaat agatcattcc tttacaagta acttaaataa ttcaataaca 1261621 tctgttatcg ttttgaattc cgaacgtttt tcgataaagg ctgtgccggt ttcgagcgcc 1261681 aagcgttttc tgccgattcg tttatcaaac ggcacgatcg tatccaggtc agctacatgg 1261741 gcaaggccga tcgtgcgtcg tatcagctca cagcccgcaa atccgattgc ttcttcaaaa 1261801 atatggctga gcgtatcagt gaggtaaccg tcgatgttgg cgtaaacatc cagactgtcc 1261861 ttctgccagg cttcactaaa cgtctcttca aacgtttccc agacctggtt gacatgttca 1261921 tataacggct ctctgtcagc cccgtcacgg ctgagtgcgt tcaaaaataa gttggcgata 1261981 aattgcccta catcaaagcc gatcggtccg taaaaagcaa actcaggatc aatcaccttt 1262041 gtttcgtgct cacttgcgaa aatgcttcct gtatgcaaat caccatgaat caacgtttct 1262101 gcagacgtta aaaatgactt tttcagctta gcggcttcga ttttaacgct gtcattattc 1262161 caaagctttt cgacaaaagg acgaagctct tcttcaaaat catttgtgtc atggtcgaag 1262221 aaaggatctg taaaaacaag tctttccgta atgtcgcata gctctggatt tgtaaactgt 1262281 ttaacaagct gttttttcac cttaggttca agcgcgtaat ctgatgagta gaaaagtgtt 1262341 tttcctaaaa attcaccgat gtgctgcgac agatgaggat agttttcacc ctcaatgagt 1262401 ccttttcttg cgatcttgag gtgagagaga tcctccatga cggtaaccgc catttccgta 1262461 tcagaataaa acactcttgg aaccaggtga ggcacatgct cgccctgacg gatgagagcg 1262521 ctgctttcga ttcttgcacg gtcgattgtc agcggccagc tttctcccac cacttttgca 1262581 tacggaaccg cctgtttaat gatcaatgct ctgtcatgtt cttgatcata aatatgaaaa 1262641 acgtaattta agttgccgtc tccgatctcc tggcatgtca gcgtgctttt gcttggaaat 1262701 aggccaagct tcaccgccaa cgccacagcg gagctttcat ttaacgtttc gtataaaggt 1262761 gtttttgtga ctcccatcat cataacctcc aattatgtaa ttaattaata tgtggccgta 1262821 aaaaagcctc cttctcagag agaaggaggc ttaacatcta tgtccgcctc tcttatctct 1262881 cagatcagat ctgaatggaa ttagcaccgt gccttaagag accagcgtct cggcgcgaaa 1262941 aaaatgcgcc ccatttcaca atggaattac ggtcggttgc ttttggggtc aaaaggccaa 1263001 atccctcgcc caactctcga taagagaata tattcacttg tttgacaatt ctaatttatc 1263061 agttgatgaa catggtaaca ggtaatttag ttagttgtca atatattttt taatataaat 1263121 cttttctgat atcatcgaaa acaggaatgc tctcccgaac ttctgcgctt tcttgaaggt 1263181 cgatttccgc tcggactatg ccttcttccc ggccgccttc agcaagtaca cgtccccatg 1263241 gatcaataat caggctatgt cctgcaaatt cattatccgg atttgaaccg gtacaattgc 1263301 aggctgcgac aaagcattgg ttttcaatgg cccgcgcaat aagcaggctt ttccaatgat 1263361 caaggcgggg aagaggccat tccgcagaaa taaacagcac gttggcgcct tttgtcgtat 1263421 gttttctgat ccattccgga aaacggatat cgtaacagat caatccagag cttttgacgc 1263481 cgtcaagctc aaagtatccg tcttcggaac cggctgataa atacagatgc tcatccatca 1263541 gctgaaaaag atgggctttt ctgtactctt taatgatttg cccttcctta tccgcgatgt 1263601 acattgtatt ataaacatca gaattcttcc tgacagcgac cgatccggcg acaatatgaa 1263661 caccatgttt ttttgccgtt ttcttcagcc agctctgagc ggagcggccg tcttcgtcag 1263721 cgagttcatc aagattggcc agatcatatc cggtcgtcca taattcaggc agaacaagaa 1263781 catcagcatg tttgctttct ttttcgatga aaaattcagc cttttttata ttttccgaag 1263841 gttttccgta tgaaatatca aattgaagac aagatatcgt ccatttcatc tttttaacac 1263901 cccaaatttt tctttacttt tttcatttaa ccatatatga tgatggacta tcatttcaag 1263961 atttttttag aaggtgagaa tagatgaaat ttgaacagtc tcatgtattg aaggaattgc 1264021 ctaaacaatt cttcgcttct ctggtgcaga aagtgaaccg aaagcttgca gaaggacatg 1264081 acgttatcaa tctgggacag ggaaatccag atcagccgac tcctgagcat attgttgagg 1264141 agatgaaacg agctgtcgct gatcctgaga atcataaata ttcgtctttt cgcggctcat 1264201 accgtctgaa gtcagcggct gctgcatttt acaaaagaga atacggcatt gatctggatc 1264261 cggaaaccga agtcgctgta ttattcggcg gaaaagccgg tctagtcgag ctcccgcaat 1264321 gcttgttgaa tcccggtgat acgattttag ttcccgatcc gggttatcct gattactggt 1264381 cgggtgtcac acttgcaaaa gcaaagatgg aaatgatgcc gctcgtaaag gacagagcgt 1264441 ttctccctga ttacagcagc ataaccgctg aaataaggga acaggcgaaa ttgatgtatt 1264501 tgaattatcc gaataatccg actggagctg ttgctacttc cgagttcttt gaagataccg 1264561 tgcgttttgc ggctgaaaac ggaatctgcg tcgttcacga ttttgcttac ggcgctgtag 1264621 gatttgacgg ctgcaagcct ttaagctttt tgcagactga aggtgcgaag gatatcggaa 1264681 ttgaaattta cacgctgtca aaaacgtata atatggcagg atggcgggtt ggctttgccg 1264741 tcggaaacgc ttcggtcatt gaagcgatca atctttatca agaccatatg tttgtcagtc 1264801 ttttcagagc gactcaggag gctgcagcag aggcactgtt agccgatcag acgtgtgtgg 1264861 cagagcaaaa tgccaggtat gagagcagga gaaacgcttg gatcacggca tgccgggaaa 1264921 tcggctggga tgtaacagct cccgcaggtt ctttttttgc atggctgcct gtgcctgaag 1264981 gctatacttc tgagcagttc tcagatcttt tgctggaaaa agcgaatgtg gcagttgcgg 1265041 ctggaaacgg cttcggtgaa tatggcgagg gctacgtcag agtcggactt ttaacaagtg 1265101 aagaaagact taaggaagcc gcttatcgaa ttggcaaact gaacctgttt acccaaaaaa 1265161 gcattgacaa gaccttataa cgatgggata attcaaaata atttataaaa tctatatttt 1265221 cttatcaaga gcaggcagag ggacgagccc gatgaagccc ggcaaccgac ttataaagca 1265281 cggtgctaat tcttgcagct agcggctgag agataagatt cggacgagaa acgaaacctc 1265341 tttagacgcg attgcagttt gaagaggttt tttgatatgg atgaaaatga aaggagctct 1265401 ggcatgagtg agttattagc gacatatctc ctgaccgaac cgggagccga tacagagaag 1265461 aaagcagaac aaatcgcaac aggattgaca gtaggctcct ggactgatct gccccttgta 1265521 aaacaggagc aaatgcaaaa gcacaagggg cgggtgataa aagttgagga gagagaggga 1265581 actgctgcat cagaaaaaca agcggtcatc acaattgcct atcctgaaat caatttctct 1265641 caggatattc cggctttgct gacaacagtg tttggcaagc tgtccctgga cggaaaaatc 1265701 aaattaatcg atcttcactt ctctgaagca tttaagcgtg cactgccggg accgaagttt 1265761 ggcgtatacg gcatccggaa gctgctggga gagtttgaga gaccgctgtt aatgagcata 1265821 tttaaaggcg taatcggaag ggacctgagt gatattaaag aacagctccg gcagcaggcg 1265881 cttggcggag ttgacttgat taaagacgat gaaattttct ttgagactgg tctagcgcct 1265941 tttgaaacaa gaattgcaga aggaaagcaa atattgaaag aaacgtatga acaaaccgga 1266001 cataaaacgc tgtatgcggt gaatttgacc ggacgtacgg ctgatctgaa agacaaagcg 1266061 agacgcgccg ccgaattggg agcggatgcg cttttgttta atgtcttcgc ttacggcttg 1266121 gacgttatgc aaggccttgc agaagatcct gaaatcccag ttccgattat ggcgcatcca 1266181 gcagtgagcg gagcgtttac gtcttctccg ttttacggtt tttctcacgc tcttttactc 1266241 ggaaaattaa accgatattg cggtgctgac ttcagcctct ttccgtctcc atatggttcg 1266301 gttgcgcttc caagagcaga tgcactggcg attcatgaag aatgtgtgag agaggatgct 1266361 tttaaccaaa catttgctgt tccgtcagca ggcattcatc ccggcatggt tccgctatta 1266421 atgcgtgatt tcggcataga ccacattatt aacgccggag gaggcgtaca tggacatccg 1266481 aacggtgccc aaggcggggg gcgagcgttc agagctatta ttgatgcggt cctagaggcc 1266541 cagccgattg atgaaaaagc cgaacaatgc aaggatctta agcttgcgct agataaatgg 1266601 ggaaaggctg aagccgtatg acgactcgaa aaccttttat tatttgtgat tttgacggaa 1266661 caatcacgat gaacgacaac attataaata tcatgaaaac atttgctccc ccagagtgga 1266721 tggcattaaa agacggcgta ctttccaaaa cgctgtcaat caaggaaggt gtcgggcgga 1266781 tgttcggcct tctgcccagc agtttaaaag aagagattac aagttttgta ttggaagatg 1266841 caaaaatcag ggaaggcttt cgggaatttg tagcatttat caatgagcac gagattccgt 1266901 tttatgtcat aagcggtgga atggactttt ttgtatatcc tttgcttgaa ggcattgtgg 1266961 agaaagaccg catttattgc aaccatgctt catttgacaa tgactatatc catattgact 1267021 ggcctcattc ctgcaagggc acatgcagca atcaatgcgg gtgctgtaag ccgtcggtca 1267081 tccatgaact ttctgaaccg aaccaatata tcatcatgat cggtgattcg gttacagatg 1267141 tggaggcagc aaagctgtct gacctatgct ttgcaaggga ttatttatta aacgaatgcc 1267201 gggagcaaaa cctcaatcat cttccgtatc aagattttta tgagatcaga aaggaaattg 1267261 agaatgtaaa ggaggtacag gaatggctgc aaaacaagaa cgctggcgag agctcgctga 1267321 agtaaaacgg gaattggcag agagagattg gtttccggcg actagcggca atctgtcaat 1267381 taaggttaca gatgagcctt taacatttct cgtcactgca agcggaaaag ataaacgcaa 1267441 agagacggtt gaagattttc tgctggtcga tcaaaacgga gagcctgctg aaagcgggca 1267501 ttctctgaaa ccgtcagcag aaacgctttt gcatacacat ttgtacaata aaaccaatgc 1267561 cggatgctgc ctgcatgtcc atacggtaaa caataatgtg atttcagagt tatacggaga 1267621 ccaaaagaaa atcacattca aaggccagga aattataaaa gcactcggct tgtgggaaga 1267681 gaacgcagaa gtgaccgttc cgattataga aaatccggca catatcccga cgctagcggc 1267741 actgtttgcg gaagagattt cagaagattc aggagctgtt ctgatccgaa atcatggtat 1267801 tacggcttgg gggaaaacag catttgaggc aaaaagagtg cttgaagcgt atgaattttt 1267861 gttcagctac catttgaaat tgaaaacact cgagcatcag ctggttaaat aaaaggagga 1267921 attgaaatgg ctacaattcg aattcatgat gaggcaaata caacgattga aaatcaagag 1267981 gaagtggcaa gctttctgga cagtcaagag gttatttatg agcaatggga tatcacgagg 1268041 cttccggaac atctctcaga gaaatatgac ctgacagaag aagaaaaaca gcaaattctt 1268101 gataccttcg aaactgaaat taaagatatc tcaacccgcc gcggctataa agcacaggat 1268161 gttatttcat tgtcagacag caatccgaaa cttgatgaac tgcttgaaaa ctttaaaaga 1268221 gagcatcacc atacagacga tgaggttcgt tttattgtaa gcggacacgg tatttttgtc 1268281 attcaaggcc aggacggcac gttttttgat gtccgtttaa accctggaga tttaatctcc 1268341 gtgcctgaga atatccgcca ttacttcacg cttcaggagg accgcaaagt tgtcgcggtg 1268401 agaatttttg tcacaactga aggctgggtt cctatttatg aaaaagacag cgtgaatcaa 1268461 taagcgtgag atagccccgt tcatcgaacg gggcttttta tatttattgc aaacgccact 1268521 tttcatattg tgacagttct tttttaatca gtgtccaaat caaacctaaa acagctgcat 1268581 cgtcaatgaa tccaagaccg aggattacgt ctggaatgat atcgagcggc atgacgatat 1268641 acaggattgc ggcagttaac agcaaaagtg ttttaacctg tgaacgaggg tagtcgccat 1268701 ttcgccaatc gcgaagcatc tgaaaaaaag tagtgatgtg ctggatacat ttttttcggt 1268761 ttttcctctt taaaatcgct tttccgcctg ccgctccgag cattattgct ttctttttct 1268821 tcattgggca tacctcctgc ctggcggcgt gtttaagata ttcttcacct gggtattgtt 1268881 cttctaatcc tatcaatata tctattatac ctgaaaaatt aacttattta atgaaaatat 1268941 gtttacaaat aaagtataat ctgtaataat gcacaataac ccaatcaaac ttgtttccta 1269001 tttcttagcg gcgaggggtg aagtgaatgg gcggttcttc tgaacaagaa agattgttgg 1269061 tgtctattga tgaaaaaaga aagttaatga tagatgccgc tagaaagcag ggatttacag 1269121 ggcatgacac gatcaggcac agtcaggagc tggattgttt aataaatgaa tatcatcagc 1269181 ttatgcaaga aaacgaacat tcccaaggga ttcaaggcct tgtaaagaaa ttaggcttgt 1269241 ggccccgcag agatgttatg ccagcatatg atgcaaataa atagcggcct atcagatgca 1269301 tatataaaga gagagctttt cggaagcgct ctttttttct ggaaaaaatt catatgaaag 1269361 agggaactaa tgaaggaact ggcgattctc attaccgaaa tggtcaatca atttcatgat 1269421 gcttttattt ccttatgcgg aatatttggc attcatttaa ctgacaaaga aatgcatttt 1269481 tgggtgatcg gcatttttgg catattcttt ttcggcgtca ctcacgctgt gtttacatgg 1269541 ctttctaaat ggagtatgac agccttgtcc tttatctata ccgttacagt catcattgtc 1269601 atcgtatttg cgattgagat tcagcaaaag gtgacgggga gagggaatat ggagttttta 1269661 gatgccacgg aaggtataaa gggtttttta gtatttttta tgtttttttt gcttttgaaa 1269721 atgctgttgc gtttcatcaa aatccttttt tctggaagac cagcaagcaa atcgaatggc 1269781 aatgcccgat cacgaagata aaaaaccctc ctgacatggt caggggggct atgatgcgga 1269841 tacggggagg gtgatcgtca cctctgtgcc tcttcgcccg ctgattgtta ttttgcttct 1269901 gtgcctcttc gcccgctgat tgttattttg ctcctctgtg cctcttcgcc cgctgattgt 1269961 tattttgccc tctgtgcctc ttcgcccgct gattgttatt ttgctcgcac tttgatttta 1270021 tcatcttcta aaatcacgtg aaaacttgtg atctcgccat tatcaagcag cagatcggtc 1270081 atttcatcct caacccattc ttggatggtt cttctaagcg gacgtgcacc gaatgaaggg 1270141 tggtagccca gctcagcgat tttttctttc gcttcatctg tcacattcaa gctaatgccc 1270201 cgttccgcca atgtttcttc aagttctcca agaagaaggc tgacgatttt gacaagatgt 1270261 tctttttcca atgagcggaa ctcaataatg ctgtcaaaac ggttgaggaa ctcaggttta 1270321 aagaacatgc tcagtgaatc aattaatgtt tgttcttcga tgacactgtc atctgattgg 1270381 aaaccgactt tcgtttgttt ctcaccagca cccgcattac ttgtcatgat gatcacagtg 1270441 tctttgaagc ttacagttct gccttggctg tctgtcagac ggccatcttc cataatttgc 1270501 aggaacatat gctgaacgtc tgggtgtgct ttttcaatct catccagcaa cacaatgctg 1270561 taaggattgc ggcgcacctt ctcagttaat tgtccagctt cctcatggcc gacatatcca 1270621 ggcggtgaac cgataatttt agatacggcg tgtttctcca tgtattcgct catatcgagt 1270681 cggataatag cgtcttttgt gccgaataat tcatctgcca gtgttttaga aagctctgtt 1270741 ttccctacgc cggtaggacc gacgaagagg aaggagccga ctggtctgtt tttggatttt 1270801 aatccggcgc ggcttcgtct taccgctttt gccacttttt gaacagcggc ttcttgtccg 1270861 atcacgcgtt catgaagttt tgcttcgagt tctttcattt tcgtttgttc gtctgcctgc 1270921 agtttgccga cagggatgcc tgttttttgt tcaacaattt cctgaatgtg ctcagcttcc 1270981 acagtgacag cggtatgagc ggaggagctg ttcagttttt tctccaatgc gagttcttca 1271041 tcacggagtt ttgccgccag ttcgtaattt tcttcttcca gggcttttgt tttttcggct 1271101 tcaattgcag ttaagcgttc agcggcatcc tcatcattca gttcatcaat taacaggttg 1271161 gcttttgaac ctgcttcatc taataaatca attgctttat ccggcaggtg tctgtcctga 1271221 atgtagcggg atgataaagt gacacatgct ttgattgctt catcactgaa tgttacgcca 1271281 tggtacgcct cgtatttgtc tttaatccct tgcagaatga ggatagcctg ttcaattgaa 1271341 ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg cggcatcttt ttcgatttga 1271401 cgatattctt tcagtgttgt cgcgccaatg acttgcagtt cgcctctggc tagggccggt 1271461 ttgagaatgt tgccggcgtc cattgatcct tctgcagagc ctgcgccgac gagaaggtga 1271521 atttcatcaa tgaacagaat gacatttttt cgttccttca gctcagtgat cagctgtttc 1271581 attctctcct caaattggcc tctgatccct gtgtttgcaa caagagatgc aacatcaagc 1271641 aagtatagct ctttgttttt tagtttgttt ggaacatcac cttcagcaat ttttaaagcg 1271701 agcccttcag cgatggcagt tttccctaca cccggctcac caataagaac cggattgttt 1271761 ttgtttcggc ggtttagaat ttcgatcact cgcgccactt catcatcacg gccgatgacg 1271821 ggatcaatga gaccggcttt tgcaccgttt gtaatatttt gagccagctc atcaagcaac 1271881 cctttttttt cgctttgttt tgctgcgctc tgttctttcg gctggaatgc ctgttcaaac 1271941 ggaaatccga aagattgagg acccatactc attgaaggtt tacgggtcag ttcgttatag 1272001 caagtttcac aaagaaccat ctgtttatga acggaattta tttgcatgtt aaggcgaatc 1272061 gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc aaaacctcct taataatttg 1272121 atcatctttg accaatgaaa gtgaataaaa aggtctattg ggtttgacct tctttgacta 1272181 ttagtatacg gcaaacttaa cggcattcaa accaatatgc tcaaagcaga ctgaatattt 1272241 gactatcttt gaccaattga tttttaaaaa aggccggttt gtttgaccaa ctttgattaa 1272301 tagtatactc tgactatctt tgactttcaa gtcttatgca caaaaatttt tgatttgtta 1272361 caaagtaaaa catgttttct tcgtcttttc aaggaacttg tctcataggt tataaaaagg 1272421 catatatgga caaaactgcg gttcgttcgg agggaagaaa tggaacaatc aaaagggtct 1272481 gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg gagctggatt tgcgactggg 1272541 agggaaattg ttgagttttt tctgaagttc ggctggttcg gttttttcgg cattctcgtc 1272601 agcggcggaa tgtttacgtt actgggggcc aagctgatga tcatttcaaa gcgaatcaat 1272661 gccaagtcat atcaagaaat gaacatattt ttgttcgggg cgacggctgg gcggattatc 1272721 aatgtattta tgctgtttgt tctccttgga gttacatctg ttatgctttc aggggcaggg 1272781 gcgctttttg aggaacagct ggggatgtcc gctcagattg ggatgctcat tacaatcggt 1272841 ctgagtttaa ttgtgatgac tagaggagta aaaggcattt tcggtgtcaa tgtgtttgtt 1272901 gttcctcttt taatcatctt ttcaatgatt gtggtggccg actcttttat attcagcgaa 1272961 tcacgaaacg cagctcagtg ggtctggccg catcgctggg attggctgtt atcagcagtt 1273021 tcttacgggg ctttaaattt atcgcttgcc caagctgttt tggttccgct ggcgaatgaa 1273081 atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg gaggcacgat gctgacgatt 1273141 gtgctgtccg cgagttttct gtctttgtcg actcttccgg atgtattttt gtatgatata 1273201 ccgatggcgc aagtggttta tctctttgca cgatctgtcc atttgattta tttactcatt 1273261 attttcggag aagtgttcac atcagttatc ggtaatctat atggattaga aaaacaagtg 1273321 caaagctttc ttccagtgaa aagcaaatat atctttgcag ccattatgat cacggcttat 1273381 attacgagcc aaatagggta cggcaggctt atttcaacga tttatccctt gtttggctat 1273441 gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag ctcctcggcg gcgcagttta 1273501 taaatatata taatgaaacg aaccgtcact atagagcgat aattgatcta ggaaccgggg 1273561 actgactttt ttattgtcaa gaaaaacatc attatggtaa gatagcagaa gtgaaaaaat 1273621 tgaagaaaat ccgtgcgata tgcgggagag gttctagcta caccctctat aaaaaactaa 1273681 ggacgagctg tatccttgga tacggccttt tttatgtttt tctagagcac cttccgaaaa 1273741 aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct cgccggcgtt tttattgcgg 1273801 agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg tatttagcgg cggtcaagac 1273861 agcacaacat gcttactgtg ggccttaaaa gaattcgaag aagtcgaaac ggtgactttt 1273921 cattataatc agcgacattc gcaggaagtt gaagtggcaa aatccattgc ggaaaagctt 1273981 ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc agcttgcacc gaatgccctg 1274041 actagaaatg atattgagat agaagtaaaa gacggcgaac tgccatccac attcgttcca 1274101 ggccgcaatt tggtattctt atcctttgcg tctatcctgg cttaccaaat tggcgcgcgc 1274161 cacattatta caggagtttg cgagacagac ttcagtggtt atcctgactg ccgtgacgaa 1274221 ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg agaagccgtt tgtgatccac 1274281 acgcctctca tgtggctcaa taaggcggaa acgtggaagc ttgcagatga gcttggcgcg 1274341 ctggattttg tgaaaaacaa cacgctgaca tgctataacg gcatcatcgc agacggctgc 1274401 ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg aagaatatat ggtgatgaaa 1274461 ggagagcgtg cataaattgt tatctcaaat ttatccgcag gcccagcatc cttattcgtt 1274521 tgaactgaat aaggacatgc atatctcagc cgctcatttt atccctcggg aaagtgcggg 1274581 agcgtgcagc agggttcacg ggcatacgta taccgtaaat ataaccgttg ccggcgacga 1274641 acttgacgat tcaggctttc ttgtcaattt cagcgtactc aaaaaactgg tgcacggaaa 1274701 ctatgatcac acgctattaa atgatcatga agatttttct caggacgacc ggtattcgct 1274761 gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac gtacaggctt atttagacac 1274821 tttggagaat aagccgacct gtgtacaggt gtttgtccgt gaaacaccga caagctactg 1274881 tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg aattcctgta ttagaaattt 1274941 tcggcccgac gattcaagga gaaggcatgg tgatcggaca gaaaacgatg ttcgtccgga 1275001 cagccggctg cgattattcc tgcagctggt gtgactccgc tttcacttgg gacgggtctg 1275061 ctaaaaaaga tattcgctgg atgacggcgg aggagatttt tgcggagctt aaggacattg 1275121 ggggagatgc gttttctcat gtgacgatct caggcggcaa cccggctctg ttaaaacagc 1275181 tggatgcttt tattgaactg ctgaaggaaa ataacatccg tgcagcgctt gaaactcaag 1275241 ggaccgttta tcaggattgg tttacgctga ttgatgacct gacaatttct ccaaaaccgc 1275301 caagctcaaa aatggtaacg aactttcaaa agcttgacca cattttaact tcacttcaag 1275361 agaatgatag acagcatgct gtcagcttga aggttgtcat ctttaatgat gaagatctgg 1275421 aatttgccaa aactgtgcac aagcggtatc cgggaatccc gttttattta caagtcggaa 1275481 atgatgacgt gcatacgaca gatgatcagt cactgattgc acatttgctt ggaaaatatg 1275541 aagcgcttgt tgataaggta gctgtcgatg cggagctgaa tctcgtcaga gtgctcccgc 1275601 agctgcacac cctgttatgg ggcaacaaac gcggagtata atagaaagga agatgaacat 1275661 gacgacaaga aaagaatcag aattagaagg tgtaacattg ctaggcaatc aaggtacaaa 1275721 ttatttgttc gaatatgcac cggacgtgct ggaatccttc cctaataaac atgtaaaccg 1275781 tgattacttt gtaaaattca attgcccgga attcacatct ttatgtccta aaacaggcca 1275841 gcctgacttt gcgacaatct acatcagcta cattcctgat gaaaaaatgg ttgaaagcaa 1275901 atcattaaag ctgtatctat tcagcttcag aaaccatggt gacttccacg aggactgcat 1275961 gaatatcatc atgaacgact tgattgaatt aatggacccg cgctacattg aagtatgggg 1276021 caaattcacg ccaagaggcg gaatttccat tgatccgtac acaaactacg gaaagcctgg 1276081 cacgaagtat gagaaaatgg ccgaataccg tatgatgaac catgatttgt atccggagac 1276141 aattgataat cgttaattat tccgttgtgt gatacggagt gtaaaaggaa gtggagtcac 1276201 agtaaaatcc gaacattcag cgttaatttt cagcggaaat gtgacctggt cacagcgaag 1276261 tgtgacccgc actaagctca ataaaagtgg gaaaagtcac acctgaaaat ggctctactc 1276321 atgggaattg tattaaaaag tgtgacctga ggtgcaacct gaactgtgac ttttatgcag 1276381 tgaaaaattg atagtacaga agcagattaa ggcgtacaat ttgtacgtct tttctttttt 1276441 atccgaaaga aaaaatgcct atctagagat cataggcatt aaatattatt atcaatatct 1276501 tcatttattt tttggctaag tttctgaacc ttctctttaa catttgaaac agctcttttt 1276561 tgaatttcat caattctcct gaatatagtc gatgacactt cttattagaa cttcactttc 1276621 aaaattgaat atctcattta tttctgactg ttcttcatct gttaggtgat ggtattgaag 1276681 ttgtttagca tttacttcag cagctacatc aatcctaact tagttgttct ggttgtacaa 1276741 tttcatattc accttctgca tactcttgct ccgcataata gcctccccat tgacagagct 1276801 cctgcaagat aggtttaaga gattctccaa gttcagtgga tgaatattca accttcggcg 1276861 gtacttgatt atacatcttt ctgctcacaa gtccactggc ttcaagctct ctaagtgttt 1276921 gaatcagcat tttctgagtt atatttggga taatgcgctt taattcactc gttctctttg 1276981 gtccattcat taaaaagtat aatacaaggc ctttccattt tccgccaata acttcctttg 1277041 tcacttcaaa cccacagcta aattttttca tgtctaaagc tctccattcc acatttatta 1277101 ctttttagtt actatatcac aaaaaagtgg gtacttccga taatgtgctt actgaaggat 1277161 actatatctt gtaagttgtt cttcaagtac ttaaaggtac tagacataaa ataaaattaa 1277221 ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa atagcgcttg taacgggtgg 1277281 aacaagtggg attggtcttg ctacagcaca aaaatttgta aacgaaggtg catatgttta 1277341 tattacggga cgtagacaaa acgaacttga taaagctgtt aaccaaattg gcaagaacgt 1277401 aaccggtgtt caaggtgata tttctaagct tgaagactta gacaaactat atgacattat 1277461 aaagcaggaa aaaggtaagt tggacattct ttttgctaat gcaggcatcg gcaacttcct 1277521 tccattaggt gaaattactg aagagcaggt tgatagaacg ttcgacatta acgttaaagg 1277581 aaccatcttt actgttcaaa aagcgttatc actattcccg gacaaagtag gttctattat 1277641 tgtaacgggc tctactgctg gatcaattgg caacccagcg tttagtgtat atggagcatc 1277701 taaagcagca ttaagagcac tagttcgcaa ctggattctt gacctaaaag gtactgaaat 1277761 ccgtgtaaat gtggttagtc caggaggtat tcttacacct gcctacgatg agctttttgg 1277821 tgatgcactt gaagaggtac tggaaaatag cagaaatact gttccagctg gaaaagttgg 1277881 gacacctgaa gaagtagcaa acgctgtatc tttccttgct tcagacgaaa gcagttactt 1277941 gacgggtgtt gaattgttcg tagatggcgg gctagcacag gtataatttc actgcgcaga 1278001 gattacaaat agtccccaaa aaaggttaat ggggatttac ttgaagaagt cgtataaaaa 1278061 agtcgttttc cttaaaggac agggaattcg acttttttat atttgaattt gattaacgtt 1278121 gtaaattcgc attttcctgg ggctactact aaatgacctg taaaaaagat tacactgtga 1278181 ataaatgtac ttaaagtaac gggggctctt gacttttaat aaaaaataat atccctgtcc 1278241 ttgtattcta atacttttaa aaatatttaa aggaatcctt atgtcctgaa taaccacata 1278301 ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca tcccacacaa gctatctcgt 1278361 gatctcacac ctgaacgttt tttatagact agtaccgcga caagttatat tacatataca 1278421 taccaataaa gtagacatta aaaagtgaaa gagaggatgg aaatgtgtga aaattctttt 1278481 ccttgagagt catcccatgt ggctctatgg tttaccgaat gggtttaggg aagcaggaca 1278541 taccgtaatg atttccggtc ctgtaagtcg ggaaaatata actgaaatga tagacgaatt 1278601 taaaccagat ttaatagtat ctatgggatg gacaccagag cattcaaggg aaaagcaggc 1278661 ctggattcgc aacgctacta aaaaggtgaa tatccctctc gtttattggg caactgaaga 1278721 cccgctgcac actcaaaact ttactatccc gttaattaaa aagatgaaac cggattttgt 1278781 tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc atggggatta aagcagctca 1278841 cttagacttt gcatttcacg aaagtataca tcaccagatt aaaccattag cgaaatacag 1278901 ttgtgatata gcagtggtgg ctaatgctta ccctaatttt cttgaagaac atccggaagt 1278961 gttccgttcg tcctctttaa aaacgcttat tcgtcctctt atacggaagg gtattcgcat 1279021 tgatttttgg gggagaaact gggaaaaaat gagtaaatat ataggaagag aaattccccg 1279081 caattggatc catggatacc ttgattatac tgaagcatat aaagtttaca gttcagcaaa 1279141 aatcattatc ggtttgcaaa actgtgaaag ccaacttaca caacgcacct atgagattct 1279201 tggttccggg gggtttttat tgacatcgga tacaccagca gttcgaggta aattcaaacc 1279261 tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca ttggaaaagg ttaaatacta 1279321 tttaaatcat gatagcgaga gaaaaaagat tcagataaac ggtaaaaagg ctgtaaagaa 1279381 tgattcctat cggcatagag ccgagagaat gcttgaggtg ctaaaaagca gaggaatcat 1279441 aagaaactta ggggaaacca ttcattatgt agatgttctc aaagaaaaat acgtgatcca 1279501 tcatgttact cccggtgaaa cattatcaat aattgccagt aagtataatg tttccctgca 1279561 gcaactcatg gagcttaatc atttcaaatc agatcaaata tatgctggac aaatcattaa 1279621 gattagagag aaactgttta gaaatattaa taacaaatta ttctaaagga gagtaatatg 1279681 aatgaagggg aaaataccta aaataagaaa tcaagcgaat aaagtaaaaa gaacgcctcg 1279741 ttatatggaa tttcccgtga catacgaagt atatcatgtg gaatccggcg atacattatg 1279801 gacgattgcc aaatcctttg aaattccggt acaacaactt atgaatctta ataagctttc 1279861 ttcagataga atttatcctg gacaaattat aaagataaga gaaagataat ctttgaggtt 1279921 tcggaagcga atcaaattga aatgacaatc ctcatttttt tatttgtggg gaacttgata 1279981 tttttgggga tgaaggggtt atgagatgtt tcaaatgagc tattactatt ctggattagg 1280041 atgggacttt attcaacacg ttgatcaaac gaacggagta ttaaatgttg tgtctcctga 1280101 ttttttctat atcagaaaag atggatcatt acttctccgt tcagctaatc ccgatgtgat 1280161 taaagctctt catagaagaa aattaaaagt agttcctttt ctaagcaatc attgggatca 1280221 ggatttggga cgatttgcat taatgaaccg agttctttta gctaaacaaa tttctcatgc 1280281 aatagaagaa ctggatttgg atggagttaa tatcgatata gaaaacctta cagaaaaaga 1280341 tcggaatcta tttacagatt ttattagatt agtaaggaaa agtattccta gacataaaga 1280401 agtatcagtt gcagtggcgg caaatccttt tggctggacg aagggctggc acggatcata 1280461 tgattacgag tatttagcta aatatgcaga ttatcttatg gttatggcct atgatgaaag 1280521 ccgccttgct gggcctactg caagtgtagg atgggtggaa aagtccattc aatatgttct 1280581 gacccaaaaa atctctcctc aaaaactagt tttaggattg ccattctatg gccgctgctg 1280641 gatggaaggc caatctgcct ctcaagccat tcccctttac cttgttgtta gtaaaaaggc 1280701 atagcgggac aattattttt gacaccaaga gtcaatctcc aaaagctatt tttactgtca 1280761 atcacgataa aaaggggccg ttgccttcgg gaacatatac attatggttt gaaaatgaac 1280821 agtcactcag agcaaaaata aaactcgctc aaaaatataa tctgaaaggt cttggcagct 1280881 ggagtcttgg acaagaagat gcgtcagtct ggaatacagt gtttaaaaat atataatgat 1280941 ttatagttca gaacaaaatt cgaagataat tgcaatgaat ctctaaatgg acatactgaa 1281001 aggagtttat tacgagtgcg ggtaaaacag tgagggcatt ccataggccc ttctcccaaa 1281061 atgttctaca cgaggcatta cattgggctt gaaatacaca ttcaaactta tgttatagta 1281121 cgcattttac ggatgtgttg aatttattct gcttccatga tttaatcata cacatgctac 1281181 ttgatagcag ggttatcgca tttcattcag aattgttcag gatcgatatg gaagcgcacg 1281241 actaactaga actttaaaag catacactca tatacttcct gaatggatgc tggtttatct 1281301 aaaaaacatg atgagaattg attgtacgca tggtgaagca tgacttgttg ataatcgacc 1281361 atatggtttc tccttagaaa tgagggggtt tttacataaa aaagacgagc gaatccgggg 1281421 ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc tggatggcag ctcgtctgtt 1281481 ttattataat ttaacgaacg tatgtttgta aaggtgtctt ttcgaatgaa ttggttcata 1281541 taaccgttaa gaacagattc attgtaaaca ttcgctaagg tatgctaaga tgcatggact 1281601 ataaaggagt gatatgaagt gaagacattg cggttaaaca atgtaacgtt agaaatggct 1281661 gcatatcaag aggagagcga gccgaagcga aaaattgcat ttaccttaaa cgttacgagt 1281721 gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa cgtttaatgt cgaggttccg 1281781 gaacgcgatc ttgccttccg gggggaaatg acaaattatt caacatcatt gaccaacctg 1281841 tacgaaccag gggccgtcag cgagttctat atagaaataa cggaaataga caaaaacgcc 1281901 gattcatgat cggtgttttt tatgtaaaaa agctgccggc cggcagcttt tgagaaagcg 1281961 aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt ttttgaataa atgtggaaat 1282021 aaggaggttt taataggagt ctctgatgat cttataattt ttatgattaa caactgtcaa 1282081 tgaatctaac tcaagatccc gatagttatc catgatcgtc acatcaacga taacagaatt 1282141 ctcatttact ttttcaacaa caccggttaa tccgttttta aattcaatga cattcccaac 1282201 cttagcgatt ttcacaagct tcctctcctt taaacataat aatgcctttt gaaagtattt 1282261 tgcagtattt tcattgagaa gtaaagcgat aaggagtttt atctccctta tgaattgttc 1282321 tgtcgctata aagatgatat attgattttc gtcaatagaa agaaaagggg ggaatttttg 1282381 ttgcgtcccg aagaaataac agaaatgatt gaacagctgc gcaccggcgc cataaacgaa 1282441 ctgagagtcc agaaagagca ttttcttgat ttcagggccg tgttatctaa acaagatgat 1282501 tttaaacatt tccgaggaat tgcccagcaa ggcggagatg ttatctttca atacttagaa 1282561 cagccaagaa gctgaaggtt tctcatacgt gagaagcctt tttatcatat atgacagaac 1282621 acaagccttt tattacagct gtctgtaaca ggtgtaaata aaatgtaaag taccaaagat 1282681 ggataaacat gttttaattt aacaatattt atagaatttc agactgtttt tttgccatta 1282741 agcagtgagt catcctcttt attccatcct gatacctcct tgggagagtt ggaaaatctt 1282801 tttccgtgaa aatgaatgga tctcttgtta aggttatgaa gtgttttttg gagcacttta 1282861 aggaggaaac tgtatgacaa cgaaattcac tgctctggct gtttttcttc tttgtttcat 1282921 gcctgcagcc aaaattgagc atacacaagc ttcactactg agcgcaaaga agacaaaaca 1282981 tgaagaagcg aaatggctta cacatataga tcgaaatacg aatgaatctt tcccttcact 1283041 gtctgctgat aaagacaaga aaataaaacc gattaagcta tcagcacaca ctgaaaagaa 1283101 agagaaagat aaaccggaca aaacaaatga tgagaaagaa acatatacac agtctgaaaa 1283161 agagttgctg tcccgtctcg ttcacgcaga ggccaaagga gaatcatata aaggcaaggt 1283221 cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa ggttttcctg atacgataag 1283281 aggagttatt tatcagaaaa acgcctttga accggtcgca aacgggagca ttaaccaaaa 1283341 gcctgataaa gaatcgattg aagctgccga agaagcgctg tcctcaaaaa atagagaaac 1283401 agatgccata ttcttttata atccgaaaac agcgtcagat aattggattc gttcaagaaa 1283461 aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa gcatagaaga gacaatttgt 1283521 ctcagctgtg ctttttttca tataaagagt aaaaataaaa taatttttga acttgtctca 1283581 tatgatgttg gtagtacaag agacaaggag agacatcatg aatcgatttg tgaaagggat 1283641 cattctttta tccattgccg cctttttcgc tgaatgcctt gaatttgtcg tcaatatgat 1283701 tttggcgcgg gagcttggcg agcatgggat ggggctttac atgagtattt tgcccacgat 1283761 ctttttaatt attgtcatcg cgagcctgga actgccgata tccatttcta aattcattgc 1283821 cgagtcaaat cctaagcttc atgaaagcat gctgaggcac gctttcagaa tgacagccat 1283881 ttttactgct ttttctactg ccgccgctag tattgcgctt ccgtttattc cggtatttga 1283941 tacataccac ccgtttatta aagggattgt catcggctta attcctgttg tcgcctttac 1284001 ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg gggaagatcg caattgccaa 1284061 tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc ttttttcaat ggtactcatt 1284121 tgaattggac atggctgtgc tgatttcctt gtttgttcta gtcgtgagtg atgtggtcgt 1284181 gcttgtttat ttatattcac aatttatcat ggcaaggcgg gcgttatccg gccagcagca 1284241 cattcatttg cgcggaaagg atgtaaggaa aagactgctt gctgtttcaa ttcctacaac 1284301 aggactgcgt atttttcatg cggttgtcaa tgcaattgaa ccctttttag taaaaggagc 1284361 tcttttggct gcgggcgttg ccgggacagc ggcgatcgat caatacggaa tgctggcagg 1284421 agtggctgtg acgatagggt cgttccctgc ttttattgcc cattcgttaa tggtcgtcat 1284481 gataccgagt atttcggaag cttatgcact ttctcagtat gacatcgtgt taaaaaggct 1284541 gaagcagtcg attttcatta cattaggtta cggtatacct gccgtctggg tcatgttcca 1284601 gtttgcggga cctctcacgc atttgttttt tcactctcct gaagcgcagt attacttgca 1284661 gctgttgtgg ccttactttc tctttcatct gtttgtcatg ccgctgcagg cgtgcttaat 1284721 cgggatgggt tttgtgaaag aggcttttta tcacaatgta tggagccata tcgttgcgct 1284781 aagtatgatg tatgtactgg gatcaatgga gaatctgcaa atgctcggga ttatccttgg 1284841 aatgaacact ggcatgattc ttttgacgag cctgcactat gccacgatct gcaaagcatt 1284901 gaaggtatct gtatttctta cgggagggac cagaacgccg cgaattgaag gatgataaag 1284961 gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag attccatgtt gacgaagcgc 1285021 ttgcttacta tatacattat gttattaggg ttgattgcat ggtttccagg tgcggcacaa 1285081 gctgaggaaa aacagcctgc tgttcccgct gtttttctta tgaaaacgat agaaggggag 1285141 gacatctcga ttccgaataa agggcaaaaa acaattctcc atttttggac gtcatggtgc 1285201 ccgccctgca aaaaggagct tccacagttt caatcgtttt atgatgccca tccatccgac 1285261 agtgtaaagc tggtaacggt gaatttagtg aattcggaac aaaatcagca agtcgttgaa 1285321 gactttatta aagcaaacaa gctgacgttt ccgattgtcc ttgactcaaa aggggaattg 1285381 atgaaggagt atcatatcat cacgatccca acatcatttt tgctgaatga aaagggagaa 1285441 attgaaaaaa caaaaattgg cccgatgaca gcggaacaac tgaaggaatg gacggaagaa 1285501 tagctgagag catagactct cagctttttt catatagaga agaagtgaat aaacattaat 1285561 gataattatt atcaaaaaga aattaaaata attataattg aaattctctt cgtgcgtgct 1285621 ataataaagg aagacatcaa gaaataactg acgataaagc tgccttttgg gcagcgattt 1285681 tgtttttata agagaaatga agatgattta cgttctcaat tagagaggag aattcgatat 1285741 gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca ttgaaaacag acaagaggga 1285801 aaaaaactgg gcacagcacg cggagcttat tgcagcactt gtatcaggcg ctcttatttt 1285861 ggcaggctgg ctcttatccg gatatcaggt attatccata atacttttct tgctggcttt 1285921 tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa gaaacactcg aatccaaaac 1285981 gctgaatgta gaacttttaa tgattttcgc tgccattggt tccgccttga tcggatactg 1286041 ggcagagggt gctattttaa tatttatttt ttccttaagc ggagctttag aaacatacac 1286101 gatgaataaa agcagcagag atttaacgtc tttaatgcag cttgagcctg aagaagcgac 1286161 attgatggtc aatggtgaaa ccaaaagagt tccggtttca gacttgcagg ccggtgatat 1286221 gattgtgatc aaacctggag aacgcgtagc ggcagacggt atcattgaat cgggctcgac 1286281 aagtcttgac gagtcggctt taacaggtga atcaatgcct gtagaaaaaa acacaggcga 1286341 cactgtattc acaggaacgg tgaatcgcaa tggctccttg acagtccgtg tcacgaaagc 1286401 aaatgaagat tcgttattca gaaaaattat caaactggtt gaatcagcgc aaaatagtgt 1286461 ttcacccgcg caggctttca tcgaacgatt tgaaaatgct tatgtgaaag gtgtgctaat 1286521 tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg ggctggagct ggagtgaaac 1286581 cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct tgtgcgcttg tcgcctctat 1286641 tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc aacggtatgc ttgtgaaagg 1286701 aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc gcctttgata aaaccggaac 1286761 tgtaacaaaa ggccagcctg ccgtagagac gatcagaata gcagaaggat tcagtgaagc 1286821 ggaagttctt gaggctgtct atgccatcga aacgcaatca agccatccgc tcgcccaagc 1286881 cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc ggctacatat ctatagaaga 1286941 aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg aaatggaagg tcggtaaagc 1287001 aggttttatc ggcgaggaaa tggcagcaca atttatgaaa caaacagcat cagatgtcat 1287061 tcaaagcggt catacaattg tatttgtgaa aaaggatgat caaatagcag gctgtatcgc 1287121 actgaaggac caaatcaggc ctgaagcaaa agaggtcatg gaagaactga accgacttgg 1287181 gattaaaacg gccatgctga caggagatca cgaagacacg gctcaagcga ttgccaagga 1287241 agccggcatg acaactgtcg tggcagaatg cctgcctgac caaaaagtga atgaaatcaa 1287301 acggttaaaa gaagaattcg gaacgattgc aatggtgggt gacggaatca atgatgcgcc 1287361 ggcactcaaa gcagcggatg tcggcattgc gatgggcggc ggaacagatg tagcacttga 1287421 gaccgctgat atggtcctca tgaaaaacga tttgaaaaag ctcgtaaaca tgtgccgctt 1287481 gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg ttttctctag ctgtaatctg 1287541 cctgctgatt tgtgcaaact ttttgcaggc gatggaattg ccatttggcg tgattggtca 1287601 tgagggcagc acgattttag tcatactaaa cggtttaaga ctcctaaaat aaaaccagca 1287661 gcctaatcag gctgctggct ttttatgtat caagctttcc cttcattttt gtctttatca 1287721 gatcttttca taactaggat gagagcgagg gtgcagcaaa ggaaacccgc tgcacagcct 1287781 atgatagagc tgtaataata aaagcccacc atcttcatcc cgataaaagg agcggaaatt 1287841 cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa aattcatcag caaacggaac 1287901 aacccccctg cgattgaacg ttactgtcag tatacaggaa gaggagcagg aaataaaatg 1287961 cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta aaacctgtta caatggaaga 1288021 cagaacaatg cattgcaaat ggcagggagg aacaagaagt gaatagaata caacgcgtct 1288081 cttcatggct gaaggaagcg gggcatactg ccgcatttat tcatacgaaa gaaaatgttt 1288141 tttacttaac cggtttttac acagagccgc atgaaagatt aatggggtta tttatttttc 1288201 aagaagagga gcctttcttt gtttgtccag gaatggaagc aggacaggcc cgcaacgcag 1288261 gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa tccgtgggag ctgatagaga 1288321 aggctttgaa aaagcgaaat atcagcatac atatgcttgc ggtagaaaag gattcaatct 1288381 cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg ggctcaattt gtttcagcag 1288441 aagaaacact caatcaattt cgcctgatta aagatgacaa tgagattcgt ttgctgaaag 1288501 aggcggcaaa gcttgcagat tacggtgttg aagtcggcac agccgctttg cgtgaaggca 1288561 tcagtgaagt ggaagtgctc gctcaaattg agtatgagct gaagaaaaaa ggaattcagg 1288621 gcatgtcttt ctctacaatg gttttattcg gagaaaaatc tggccagcct catggaaatc 1288681 ctggtacagc cacgttgaag aaaggtgatt ttgttttatt tgatctcggt gttattcttg 1288741 atggctattg ctctgatatt acaagaacgt ttgcatacaa aaccatcaat ccgaagcagg 1288801 aggccattta cgagactgtg cttcaagcgg aaaaagccgc gattgaggca agcaaacccg 1288861 gtgtgagaat cggagatctg gatttaactg cccgcggaat cattgaaaaa gcgggatatg 1288921 gtgattattt tcctcaccgg cttgggcatg gactcggaat ttcagtccat gagtatccat 1288981 caatgagcca ggccaacgat acactgctgc aggaaggcat ggtctacacg atcgaaccgg 1289041 ggatttatgt gccagagatc ggcggcgtac gcattgagga tgacgttcac gtaacaaagg 1289101 acggagcagt tgctctgacc caatatccaa aggatttgat catactgtaa tagaaataaa 1289161 aaaggacttt gttctcgaca tcgtcctttt ttatctgcat taaataaaaa aatcatcaaa 1289221 tgttcgaaag ggtttaattt catgtttttg gttgagaggt tttacagcaa gacagctgcc 1289281 accgagaaca gtgagacata acccaattaa aatgaagaaa cccatgtgat cttctccttt 1289341 cagctaaaaa cacaaaaaga tatctggtac gtccatatca tattgtatga aacgcattcc 1289401 agatcaaggg gatttagaaa gaagggaatc tatggctaat attaaagaca ttgcagagaa 1289461 agccggtgtc tctgttacaa cggtttcccg agtcataaac aatcatccat acgtcagtga 1289521 agacaaacga aaaagagtgt ttgaggcaat ggaatcattg gagtacacga gaaatattca 1289581 cgctgtacat ttgtcgaaag gattttcaaa catgattggt gttgtcttgc cgacggttaa 1289641 tctgccatat tttgcagagc tgattgcagg aatagccgac gcagccgcgg aatccggggt 1289701 tcacctctct ttattccaaa caaactatga agtacaaaaa gaaatctttg cgctgtccca 1289761 attaaagcag cgccaggttg acggcctgat tttttgctca aaggcgcttg ctgatgagaa 1289821 actcatggaa tgggagggcc cgattttgct ttgccagaat tcagataatg cccgcttccc 1289881 aaccatcagc attcctcacc aagaagcatt tcggaacggc ttggactatt taattgccaa 1289941 agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa ggcatgaaca gccattttcg 1290001 aatcaaagcc tacaaagagg cattggaaga gatcggcgag gcatttcgtg aagactgggt 1290061 aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt tttcataaat ggaatacgtg 1290121 gaaggaaaag ccgacggcta tttttgttgc caatgaccaa gtctcagcag ggctttttct 1290181 tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt gcaatcttaa gcgttgataa 1290241 ccacgaaatc agccaagcgc ttggaatcac aacgatcgat attcagacaa gggaaatggg 1290301 aaagcaggca tttgccatat tggaaaaaag aattcaagga cagccgattg aaaggaaagt 1290361 tctggattac cgtctcatcg aaagatcgac tgtttagtga atgcattgaa aaaaggtttg 1290421 acgtgcattc tgttcgttat gtacgatatg aggtattgaa tgacaaagga gctgaggatc 1290481 gtgaatgggt ccttcacagt gaaaaaggta ctgaataata acgtattaat tgcttctcat 1290541 cataaataca gcgaagtcgt tttaatcgga aaaggtattg gtttcggaaa aaaacaagat 1290601 gatgtcattg aagataaagg ctacgataaa atgttcattt taaaagacga gaaggaacaa 1290661 aagcagttta aaaagctcct tgactatgtt gatgaaaagc tcgttgatat ttcaaacgat 1290721 gtcatctatc acataagcaa taggacgaat cactcattaa atgaacatat tcacattgcg 1290781 ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc agggatttga tatgaaaaat 1290841 ccatttctaa tggagactca gtcactatat cctgaggagt accaaattgc caaagaagtc 1290901 atagatatga tcaatgaaaa agcgggactc tgccttccgg aaggggagat tggttttatc 1290961 gctctgcata tccattcagc gttgacaaac cgtccgctgt ccgaggtcaa tcagcactct 1291021 cagctcatgg cgcagcttgt cgaggtgatt gaagactcat ttcaaatgaa agtaaataag 1291081 gaaagtgtca actatttgcg gctgatcagg catatcagat ttacaataga aagaattaaa 1291141 aaagaagaac cgactaaaga accagaaaaa ttaatgttgt tattgaaaaa tgaatatccg 1291201 ctatgctaca atacagcttg gaaattgatt aaaatcttgc agcaaacatt gaagaaacca 1291261 gttcatgagg cggaagcggt ttatctgacg cttcatctgt accgattaac caataaaatt 1291321 tcataaattc agtttatcct tataacgtgt tactgattcg atcaggcatg agtgattgag 1291381 ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc caattttgct catgcctttt 1291441 tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag acttacgcct gtgaattcgt 1291501 tgtcatgatt tttagctgta aggtcagact agtaaaaaga ggaggtcaat tcttatgttt 1291561 aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc ttatgcttcc agttgcgatc 1291621 cttccggctg cgggtatttt gcttgcgatc gggaatgcga tgcaaaataa ggacatgatt 1291681 caggtcctgc atttcttgag caatgacaat gttcagcttg tagcaggtgt gatggaaagt 1291741 gctgggcaga ttgttttcga taaccttccg cttcttttcg cagtaggtgt agccatcggg 1291801 cttgccaatg gtgatggagt tgcagggatt gcagcaatta tcggttatct tgtaatgaat 1291861 gtatccatga gtgcggttct tcttgcaaac ggaaccattc cttcggattc agttgaaaga 1291921 gccaagttct ttacggaaaa ccatcctgca tatgtaaaca tgcttggtat acctaccttg 1291981 gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag ctgcattatt gtttaacaga 1292041 ttttacacaa ttgaactgcc gcaatacctt ggtttctttg cgggtaaacg tttcgttcca 1292101 attgttacgt caatttctgc actgattctg ggtcttatta tgttagtgat ctggcctcca 1292161 atccagcatg gattgaatgc cttttcaaca ggattagtgg aagcgaatcc aacccttgct 1292221 gcatttatct tcggggtgat tgaacgttcg cttatcccat tcggattgca ccatattttc 1292281 tattcaccgt tctggtatga attcttcagc tataagagtg cagcaggaga aatcatccgc 1292341 ggggatcagc gtatctttat ggcgcagatt aaagacggcg tacagttaac ggcaggtacg 1292401 ttcatgacag gtaaatatcc atttatgatg ttcggtctgc ctgctgcggc gcttgccatt 1292461 tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag gtattatggg ttcagcggcc 1292521 ttgacatctt tcttaacggg gatcacagag ccattggaat tttctttctt attcgttgct 1292581 ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt cattcatggt catgcagctg 1292641 ttgaatgtta agattggtat gacattctcc ggcggtttaa ttgactactt cctattcggt 1292701 attttaccaa accggacggc atggtggctt gtcatccctg tcggcttagg gttagcggtc 1292761 atttactact ttggattccg atttgccatc cgcaaattta atctgaaaac acctggacgc 1292821 gaggatgctg cggaagaaac agcagcacct gggaaaacag gtgaagcagg agatcttcct 1292881 tatgagattc tgcaggcaat gggtgaccag gaaaacatca aacaccttga tgcttgtatc 1292941 actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg ataaagaccg tctgaaacag 1293001 cttggcgctt ccggagtgct ggaagtcggc aacaacattc aggctatttt cggaccgcgt 1293061 tctgacgggt taaaaacaca aatgcaagac attattgcgg gacgcaagcc tagacctgag 1293121 ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg aggaagtgat tgcagaaccg 1293181 ctgcaaaatg aaatcggcga ggaagttttc gtttctccga ttaccgggga aattcaccca 1293241 attacggatg ttcctgacca agtcttctca gggaaaatga tgggtgacgg ttttgcgatt 1293301 ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa aaattctcaa tgtgttcccg 1293361 acaaaacatg cgatcggcct gcaatccgac ggcggaagag aaattttaat ccactttggt 1293421 attgataccg tcagcctgaa gggcgaagga tttacgtctt tcgtatcaga aggagaccgc 1293481 gttgagcctg gacaaaaact tcttgaagtt gatctggatg cagtcaaacc gaatgtacca 1293541 tctctcatga caccgattgt atttacaaac cttgctgaag gagaaacagt cagcattaaa 1293601 gcaagcggtt cagtcaacag agaacaagaa gatattgtga agattgaaaa ataagggtgt 1293661 tagtacgccg tgcttgtcag atgacaagta cggttgtatg atataatatt gtgaagtaat 1293721 aaagctttaa gttaaaagga gaatgataaa aatggcacaa aaaacattta aagtaactgc 1293781 agattctgga atccatgctc gtcctgcgac agttcttgta caaactgcta gcaaatacga 1293841 cgctgacgtt aatttagaat ataacggcaa aacagttaac cttaaatcta ttatgggtgt 1293901 tatgtcttta ggtatcgcta aaggcgctga gatcacaatc tctgcttccg gagctgacga 1293961 aaacgatgct cttaacgctt tagaagaaac aatgaaaagc gaaggactcg gcgagtaatg 1294021 caagaattaa aagggattgg tgcttcagcc ggcatcgcga ttgcaaaagc gtaccggctt 1294081 gaagagccag atttaacggt tgaaaagaaa aacatctctg attctgaagc ggaagtaagc 1294141 cgttttgatg aagcgattgc acgttcaaaa gaagagctcg aaaaaatcaa agagcacgct 1294201 ttgaaagaac tgggtcagga taaagctgat attttttctg ctcacctttt agttctcagt 1294261 gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca ctgattcagt gaacgctgaa 1294321 ttcgctttaa aagaaacgtc ttctatgttc gttactatgt ttgaatctat ggacaacgaa 1294381 tatatgaaag agcgtgcggc agatatccgc gatgtaacaa aacgcgtaac cggccacctg 1294441 cttggcgtcg aaattccaaa cccaagcatg atctcagaag aggttattat tgtagctgaa 1294501 gacttaacac cgtctgacac agctcaatta aaccgtgagt tcgtaaaagg attcactact 1294561 gatatcggcg gacgcacatc tcactctgcc atcatggcac gttctcttga gattccagca 1294621 gttgttggaa cgaaagctgc tacaggcacg atccaaaacg gcgtgactgt tatcgttgac 1294681 ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa ctgtaaaaga gtatgaagaa 1294741 aaacataatg cttatttggc tcaaaaagct gagtgggcga agcttgtcaa tgaaccgact 1294801 gtctcaaaag acggacatca tgtagagctt gcagcgaaca tcggtactcc tgatgatgta 1294861 aaaggtgttc ttgaaaacgg cggagaagca gttggccttt accgtacaga attcctttac 1294921 atgggaagag atcagctgcc tacagaagat gagcagtttg atgcttacaa aacggttctt 1294981 gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg atatcggcgg agacaaagag 1295041 cttccttacc tgcagcttcc taaagaaatg aacccgttcc tgggatatag agcgattcgt 1295101 ctttgccttg aagagcaaga aatcttcaga acacagcttc gcgcgctgct tcgtgcaagt 1295161 acatacggaa acttgaaaat catgttccct atgattgcga cagttaacga attcaaagaa 1295221 gcaaaagcga tccttcttga agagaaagaa aagctcgtaa aagcgggaca ggctgtatct 1295281 gacgatattg aagtcggaat gatggttgag attccgtcaa ctgcagtcat cgctgatcag 1295341 tttgctaaag aggttgattt cttcagtatc ggaacaaacg atttgattca atacacaatg 1295401 gcagctgacc gtatgaatga acgtgtatct tacctgtatc agccatacaa cccggcaatc 1295461 cttcgcttaa ttacactggt aattgaagca gcacacaaag aaggaaaatg ggttggcatg 1295521 tgcggagaaa tggcaggaga cgagattgcg attccgatcc ttctcggctt aggcttagat 1295581 gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa cacaaatcag caaattgtct 1295641 aaacaagaag ctgagtcatt caaagagaaa atcttatcta tgagcacgac agaagaagtt 1295701 gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa ccagacggcc tccggcctgt 1295761 ctggtttttt tcataagtaa gggtatagaa ggacacaata acatggctag gagggatagt 1295821 atgtcaaacc aatttaacgc aggagatact gtttatgtga tctacagaaa tccgcacgcc 1295881 gccaatgtag cccacataaa ggaagccgaa attgtgcacc atccatacca tgaaggcgag 1295941 ctttccctgt ttatttatga aacctatcat ccattcgcag aggacgatgc tgtgtttgca 1296001 agctatgaag aagctaaatc gctttacaaa gaactgtttg atattgatcc gtatgagtaa 1296061 caaggaaatc attacaactc atatcctttc cgcctagtga gaaaagtaac gttagtaaag 1296121 gaaaaggatg tggcatcatg cagaacccat ttgttccgca gcttgtgtat atagaaccga 1296181 gggcgctgga atatccgctg ggccaagaat tacaagataa atttgagaat atgggtattg 1296241 aaatcagaga aacgacatcc cacaatcagg tgcgtaatat ccctgggaaa aatcatcttc 1296301 agcaatatcg caatgcgaaa tcaactttag ttatcggtgt ccggaaaaca ttaaagtttg 1296361 attcatccaa accctcggcc gaatatgcca ttccgtttgc aacaggctgc atggggcatt 1296421 gtcattactg ctacctgcaa acaaccatgg gatcaaagcc gtatatcaga acttatgtaa 1296481 acgtcgaaga gattttagat caggcagata agtatatgaa ggagcgcgca ccagagttca 1296541 caaggttcga agcatcatgt acgtcagaca ttgtaggaat tgatcatctg acacacacgc 1296601 tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg aaagctccga tttgtaacga 1296661 aatttcatca tgtcgatcac ctattagacg caaagcataa cgggaaaacg agattcagat 1296721 tcagtattaa tgccgactat gtgattaaaa actttgagcc gggaacttca cctcttgata 1296781 agcggataga agcggcagta aaagttgcaa aagcaggcta cccgctaggc tttattgttg 1296841 ctccgattta tattcatgaa ggctgggaag aaggatacag acatctgttt gaaaagctag 1296901 atgctgcttt gccgcaggac gttagacatg acattacgtt tgaattaatt caacaccgtt 1296961 ttacaaaacc ggccaaacga gtgatagaga aaaattatcc gaagacgaag ctcgaattag 1297021 atgaagaaaa gcgccgttat aaatggggcc gttacgggat cggaaaatat atttatcaga 1297081 aagatgaaga gcatgcactt cgagaggcac ttgaatccta tattgatacc tttttcccta 1297141 acgcaaaaat tgaatatttc acttaaacgg gctgttgtga tcaacagctc gcttttttat 1297201 aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa tgattcttta tcctccaaat 1297261 aattgctgac tacacgaata ggtgaacgcc cgcaacggag gagaaaggac agcacagggt 1297321 cgtttttcct gccttccatc acatcttcaa cgtactgaac agcgctgatc tcgtgtgcgt 1297381 atttataata caaaggaatg cggccgccgc cgagaaggcg ttccagtctt ttatcaacag 1297441 tcagctcata catcgtattc atcagccatt ttccgattcc aagctttcga taatgaggag 1297501 aaacagaaat atccactaca tataaagtat ttccatgagg ttcatgattt ttaatcgatc 1297561 cgttgtcagt tgcttgtgcc catgtatgat caggagaatc aggctcaaat tgtacaataa 1297621 gagcagtcat ggaaccgata attctgccat tgatgagcgc gcataaagcg ccttccggaa 1297681 aggttttgat atggctggca agctggtcct ctgaccacag caattcctgg ggaaacggag 1297741 gagggaaaca ttcttcttga agagaaatca gcctctcgat gtcagtctca gtgtagtttc 1297801 taatggtcag agcctcaaat tttctgccgt catgcacata catttgtttt agtatgatca 1297861 tcactctcct tatgttgttt cattataacg aagattgaat tttcagtaaa tatattccga 1297921 ttttcttata atttattttt tgattattca tttttcaaac gaaagggccg atatagaaat 1297981 taggagggga ttggtttgtt taaaaaactt cacatgaaga ttgctgtttt tgtttcgatt 1298041 atgttaatca tcacagttgt tctcttaatg ctgtcttctt atttgacgct aaaaccgatg 1298101 attacagagg atgggaaaaa tacaactcaa aacgtgacgc agtcacttga acaaaatatt 1298161 gaattgcaat taaagagtta tgccatttcg ttatcaagat tggctaatgg ggaattaacg 1298221 catacatttg taacgaaacc aagtaaagaa gcttctcggc tgtttcacga tgacattaag 1298281 caaatcaaag acaacgatga ttatgttgcg atggcttaca taggcaccgc aaaaaaagaa 1298341 atgtttacat atccaaaagc ggatttcgct gaggattacg atccaacatc aagaccatgg 1298401 tataagcttg cagctgaaac cccggatcaa gttgtttgga cggaacctta taaagatgtc 1298461 gtgacaggag acatgattgt tactgcatcg aaagcgatct tagacaggca aaaagtgata 1298521 ggggttgcca gctatgactt gaaactctct gctatccaga gtatggtcaa taaacaaaag 1298581 gtgccttaca aaggatttgc ctttttagct gatgcgagcg gcaatctttt agcccatccg 1298641 tcaaatcaag gaaaaaatat atcaaaggat caaacactgc aaaccatcgc atccgagaaa 1298701 aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc aaacgattgg cgagacaggc 1298761 tggaaggtcg gaacgcaatt tgataccgat caattaatgt ggatttcaga taaaatgaat 1298821 cgggccaatc tttggatatc attgattgcg cttatcataa caattattct cagctacttc 1298881 ctggccaaaa cgataaccgg tccgatacag cagctgatcg taaaaacgaa agctgtttcc 1298941 gcaggcgatt taacagtgcg cgcggaatca aaatctaagg atgaagtcgg tattttaaca 1299001 agagatttca atctgatggt tgaaaatatg aaggaaatgg ttgagcaagt gagactctct 1299061 tcagggaaag tatctgacac ctctgaacaa ctaacggctg tggctgccga aactaatgaa 1299121 acaagcggac aaattgcaaa agcgattgaa gaagtagccg caggggcatc ggaacaggct 1299181 tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt caacgaaaat caggcaaatc 1299241 gctgaggagg caggcggaat taaagaacgc tcaaaatcgt ccgaggatgc aagctataaa 1299301 ggacttgacg cgctcggcca gctgctgatg aaatcaaacg aagccaatat ggaaacgaaa 1299361 aaggttgaaa cgatgctgct ggatttggaa aatcaaacta agaatattga agaagtcgtt 1299421 acagcgattt caaacatatc tgatcaaacc aacttgcttg ccttaaatgc cagtattgag 1299481 gcagccagag ccggagaaag cgggcgcggt tttgccgtcg tagccgatga agtgcggaag 1299541 ttagctgagc aatcagccct ttctacaaag catatcagcg agactgtgaa gcttatccag 1299601 cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa gcagaatgaa tgatgaacaa 1299661 aacagtgcaa ttcacgaaac tggagaggta ttaaatacga taactgcaga aatgcagtca 1299721 ctggtacaag gtattgatca catttacgcg gaaattcaaa gaatgagtga agaacagctt 1299781 gcgatttctg aagccattca aagcatttca gccatatcac aggaatcagc tgccgcagca 1299841 gaggaagtga acgcatcaac cgatgaacag cttgtcaccc ttgataaagt caaacactca 1299901 acggaaacac taaaacatgc aagccaagag cttatgaaca caattgcaaa attcacattg 1299961 taatccaatt acatccccaa acatcatttg ttttggggat tttttatttt ataagatgaa 1300021 tagatatggt agtctagaaa atgaaggaaa aatgataaat tttaactaaa atctaaacga 1300081 aacatctggg aggaatgacc ttgaaaaaaa caattggttt tatcggtctt ggagtaatgg 1300141 gaaaaagcat ggcatcacat attctcaatg acggccatcc tgtattggtg tacacccgga 1300201 caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat ctggaaagat acggtcaaag 1300261 atctttcgaa agaagcggat gttatcatca caatggtcgg ctatcccagt gatgttgaag 1300321 aagtgtattt cggaagcaat ggaattattg aaaacgcaaa agaaggtgca tatcttattg 1300381 atatgacgac atctaagcct tcgcttgcga agaagattgc tgaagcggcc aaagaaaaag 1300441 cattgttcgc tttagacgct cctgtttccg gtggagacat cggtgcacaa aacggaacac 1300501 tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc ctgcatgccg attttctctt 1300561 taatgggaga gaatattcag tatcaaggac cggctggaag cggacagcat accaagatgt 1300621 gcaatcagat tgcaattgca gccggtatga tcggtgttgc tgaagcgatg gcttatgccc 1300681 aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat cacaacgggc gcagccggaa 1300741 gctggtcatt gtcaaatctt gctccccgta tgctgcaagg caactttgaa ccgggatttt 1300801 atgtgaagca ttttattaag gatatgggaa ttgcactaga ggaagcagaa ttaatggggg 1300861 aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga caagctagct gctcaaggtg 1300921 aagaaaacag cggaacacag agtatatata agctttgggt gaaataaaaa aagattgcct 1300981 gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa ttgttgtgtc cagatgcttc 1301041 cagactcaac gtaaccaaca ccgatgtgag taaagttagg gtttagaatg ttttttctgt 1301101 gtccttcact gttcatccaa gcttttacta cttcttctgg tgtcttttgg cccttcgcaa 1301161 tgttttcacc tgctgttttg tagctgattc cgaaagattt catcatatca aacggtgagc 1301221 cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt catatcctga gattttgcgc 1301281 gtgcagattt gcttaacgtt tcatcaattt gaagcggttt taagccttgt ttttgtcttt 1301341 ctgcatttgt aagttcaaca acttttttct catatgcact tacagatgaa ggtgcagacg 1301401 ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga agcagtgttt tgatcagcag 1301461 ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc tgtcttttga acatcctgaa 1301521 ctttcacgtt agattgcttc gcatgttttt gaagaagctg cttcatctct ttttcgtttg 1301581 cagcgtttaa cgttttgata tttgtgttaa tatgcagttt tttcactgca tcgttaagtg 1301641 acatgttttg tactgtgttc cccgttttta ctgtaaccac aggctggcag gagagttctt 1301701 tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc aaccgcagcg gcagcagata 1301761 aaataaatgc tttcttcatt agttcgtaac ctcctagagt tgtttgtttc tacagaaaaa 1301821 tcataacata gcttttttgt cataaagatt ccagcacttt cctttgacaa atagagattg 1301881 tcattttcgt aaagtaaatc cgttgaatca ctaagaataa gggaatcagc ggtatatatg 1301941 attttatcgt accgttacat agcttccttt tttttgaacc gttagttata ttttaatgtg 1302001 tttttatatt gacagctttt tttactcctt ttcgctgtaa caactattac aaaggtgtta 1302061 caattaatct cagtatatgt aaatatattg aatgatttga gaggggtaac cagaagtgac 1302121 tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac agagcaatca gaatgaacct 1302181 ttttttccta gctgtctttg ttctattcac tgcattaatt tttaagctcg gggttgttca 1302241 aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa tcaaatgcaa aaacagctta 1302301 ctatcctgcg cctcgcggga agatgtacga cagaaaccag aaagttgctg tcgacaacca 1302361 gagcgttcca gaaattgtgt atgtatcaac atctagcaca aaaacagaag ataaaatcaa 1302421 aacagcgaag cggcttgctt ctttcattca tattgatacc gaatttttga aggaaaggga 1302481 tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc gccgctctgc ttaaggaatc 1302541 agaaagcaat ctgaaaggag accaggctta caagcttcaa atagagcgtg ttccggatca 1302601 agaattaaag gctattcagc aagatgacga agaaatggaa actgctgcga tatatacaag 1302661 gttttcaagc ggaaatgctt acgaacctca aatcgtaaag gcaatgaatc caaataagag 1302721 caatagcaat ggaaaaaacg gagcgctgct tgatgagaag aaaaactcct cgcaaagacc 1302781 aaaaaatgac ttaacatatg atgaaatttc cattgtttct gagcatttag aagaacttcc 1302841 gggaatcgat atcgtaaacg attggacacg aaaatatcct tatgacaaaa ccctttattc 1302901 tgttttcggg ggcgtcacga cacctgatca gggcctgctg agcgaccgga aagatttcta 1302961 cttaacaaga ggctatgcga ataatgacag ggtgggaaaa agttatttag agtatcaata 1303021 tgaagaatat ttaaattcgc ataaagaaaa agtggaatac gtagaagata ataaaggaaa 1303081 tgtcgtcagc caaaaaacca ttgataaggg cagcagggga tacgatcttc agctttcttt 1303141 tgacatggag cttcaggcaa aggtagaaaa gatcattgaa gaagaagtaa gaaacagccg 1303201 tgcacgcgga aattacatgc ttgacagagc ctttgccgta atgatggacc cgaataacgg 1303261 cgatatttta tcaatggcag ggaaaaagat agatttaaaa accaacaaaa ttgaagatta 1303321 tgcgataggg gcatttacca cccaatatga aatgggatca gcagtaaagg gggccaccgt 1303381 gctagccggc tatcaggacg ggatcccgca ttataaatat tatatcgatg ctccaatgct 1303441 tttaggaacg aatcttataa aaaaatctta tactaatatg ggaaccatca atgaattaac 1303501 cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt gccatgcata ttgcaggcgt 1303561 aacatacaag ccgcatggat ctctcccggc tgatcagaac gatctactga aaatgagaaa 1303621 ctattacagc cagtttggtc tgggagtaaa gacaggtatt gatctcccgc aggaatcagc 1303681 cggaatgcaa accacaccta aaactgtagg aggattaatt ttagacttag caattggcca 1303741 atacgataca tacacaccgc ttcaaatggc tcaatacatc tcagtaatcg ccaatggtgg 1303801 ctatcgtgtt cagcctagaa tcgtcacaag tattcataag ccaggaaaaa aagaccagct 1303861 gggtaaggcg attgaacata ggaaacctaa agtactcaat aagattaata attcagagag 1303921 cgatttgaaa caagtacaaa caggcatgaa attagtcact tcttcaggga cagcaaaaaa 1303981 tacgtttaca gaagatgtat cagggaaaac gggaacagcg gaaacatttt actacggcac 1304041 gaatcgcaac tggtggggga aaaaaacata caatctgact tttgtcggct attacccgtc 1304101 gaaaaaacca aaagtggcct ttagtgttgt tgttccatca gtagatgatg atgataagat 1304161 caataaaatt attgccaaaa gagctatcca cgcctacgca gagctcgaaa aaaaacacag 1304221 taaaaaataa aaaacagggt gcacaactaa aagattgtgt gccctttctt ttattcaaaa 1304281 attgacgttc accataagaa tagaaggaga atactcattt tctagcgaat catactaggt 1304341 aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca aaggagggat tctgtggaac 1304401 aggatacgca gcatgttaaa ccacttcaaa caaaaaccga tattcatgca gtcttggcct 1304461 ctaatggacg catcatttat atatctgcca actccaaact gcatttgggc tatctccaag 1304521 gagagatgat cggatcattc ctcaaaacgt ttctgcatga ggaagaccaa tttttggttg 1304581 aaagctattt ttataatgaa catcatctga tgccgtgcac ctttcgtttt attaaaaaag 1304641 atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt tacgacaaga gctgagcgga 1304701 cagaacggga aatcattttg aaaatgaagg ttcttgaaga agaaacaggc catcaatccc 1304761 taaactgcga aaaacatgaa atcgaacctg caagcccgga atcgactaca tatataacgg 1304821 atgattatga acggttggtt gaaaatctcc cgagtccgct atgcatcagt gtcaaaggca 1304881 agatcgtcta tgtaaacagc gcgatgcttt caatgctggg agccaaaagc aaggatgcta 1304941 ttattggtaa atcgtcctat gaatttattg aagaagaata tcatgatatc gtgaaaaaca 1305001 ggattatacg aatgcaaaaa ggaatggaag tcggaatgat tgaacagacg tggaaaaggc 1305061 ttgatggcac acctgttcat ttagaagtga aagcatcccc gaccgtctac aaaaaccagc 1305121 aggctgagct gctgctgctg atcgatatct cttcaaggaa aaaattccaa accatcctgc 1305181 aaaaaagccg tgaacgatat cagctgctga ttcaaaattc cattgatacc attgcggtga 1305241 ttcacaatgg aaaatgggta tttatgaatg aatcgggaat ttccctgttt gaagcggcta 1305301 catatgagga tttaattggc aaaaacatat acgatcagct gcatccttgc gatcacgagg 1305361 atgtaaaaga gagaatccaa aacattgccg agcaaaaaac agaatctgaa attgtcaagc 1305421 aatcctggtt cacctttcag aacagggtca tctatacgga gatggtctgc attccgacga 1305481 ccttttttgg tgaagcggcc gtccaggtca ttcttcggga catctcagag agaaaacaaa 1305541 cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc agggcagctc gcggcgggaa 1305601 tcgcccatga gatccgcaac cctcttacag cgatcaaagg atttttacag ctgatgaaac 1305661 cgacaatgga aggcaacgaa cattactttg atattgtgtt ttctgaactc agccgtatcg 1305721 aattaatact cagtgaactg ctcatgctgg cgaaacctca gcaaaatgct gtcaaagaat 1305781 atttgaactt gaaaaaatta attggtgagg tttcagccct gttagaaacg caggcgaatt 1305841 taaatggcat ttttatcaga acaagttatg aaaaagacag catttatata aacggggatc 1305901 aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa tgcagttgaa tcaatgcctg 1305961 atgggggaac agtagacatt atcataaccg aagatgagca ttctgttcat gttactgtca 1306021 aagacgaagg ggaaggtata cctgaaaagg tactaaaccg gattggagag ccatttttaa 1306081 caacaaaaga aaaaggtacg gggcttggat taatggtgac atttaatatc attgaaaacc 1306141 atcagggagt tatacatgtg gacagccatc ctgaaaaagg cacagcgttt aaaatttcat 1306201 ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt atcgtctgca ttgcttcacg 1306261 tttttttaat acaaataatt ctaaacggtc taggccttct ctcagcgtgt ccattgagca 1306321 tgcaaaagac agccttacat atccttcacc atatgttgag aacgagctgc ccggcacgag 1306381 tgccacgcca gcgtcttcca aaagagccat actaaaatca aatgaagtca ttccaaatga 1306441 tttaatagaa gggaagatat aaaacgcacc ggacggttta actacgtcaa gtcccatgga 1306501 aacaagacgg tcataaacat agtccagacg ttttttgtat tgttctctca taatcaatgc 1306561 atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt tgagaaatgg atgaggcgca 1306621 cgacacattg tattgatgaa cctttaaaat gtgctttgca atgtctttcg gtgcaaataa 1306681 aaatccaatt ctccaaccgg tcatgctgtg tgattttgac aacccgttaa tgacaatcgt 1306741 ttgatcccgc aaataggttg cgatggagta atgcggtctg tcatatgtta attcactgta 1306801 tatttcatca gacaatacga agacatttct gccttttaag agagctgcga tgcttttcag 1306861 ttcttcttca gataaagtca cgccggtagg gtttgacgga taaggaagca cgacacactt 1306921 ggtgttgggt gtcagagcat cttcaatcag ccgggcggta agcttaaagc cgtgtgacgt 1306981 agtatcaaca atgacaggct tggccccgca caaattgata ataggttcat agcccggata 1307041 aataggccct ggcataatga cttcatcacc gggagataaa atcgtccgga atgcagcatc 1307101 aatggcttgg cttgcgcctg ttgtgatgat aatttcagat tcagcatcat agttgaaatc 1307161 cgcttttttc ttcatataaa gctgcacagc ttgtctcagc tccaggtagc cggcattcgg 1307221 agtatatgac gtcacgtttt catcaatggc tttttttgcg gcagctttca catgatgcgg 1307281 tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg tcttcgtgtt gggctacaag 1307341 attcgagaat ttgcgtattc ctgaaatttc gatctctctt gctttcggat tcagcaaatg 1307401 ttccataatt catcacctta acaaatataa tgagtttatc ctattttacc actagctgat 1307461 catttgtcac ctttttaact gatatatttc gattgtatgc gccttttttc taaacatacc 1307521 tttcttttca gaaaaaaaga agacaaccag cgatttgatt gtctttattg tatcatgttc 1307581 tattattgtt tatatgtgcc aatttcatta atagccataa tcaaaatgaa ggtcttcgtg 1307641 ccaaatcaga tacggaggat gctcttcttg aaggtcagct gattctttct tcatattcag 1307701 gtaagtttct tcactgatat cctctaaaac agtcatttcg ttttctttaa atattactaa 1307761 ggtacccatt atttacaccc ttctttggaa aaatccttga ctattttatc actgttagtt 1307821 ggaaagtcaa tggttattag gaaaaaagtt tcttttttga ggaacgcggc ttgttgcctt 1307881 cggaattcga ttttgaagag ctgccattca ctttttacaa attacgccga tatatacagt 1307941 acaatactga atgcgaatag cgagggattg aattgtcgtt acaacaatac gaaattttat 1308001 tggattctgg tacaaatgaa ttagaaattg tgaagtttgg cgtgggtgaa aatgctttcg 1308061 gaattaacgt catgaaggta agagaaatta ttcagcctgt cgaggtgaca tcagtgcctc 1308121 actcccatca gcatgtagaa ggaatgatta aactcagagg agaaatcctc cctgtgatca 1308181 gtctcttctc attttttgga gtagagcctg aaggatcaaa agatgagaaa tatatcgtga 1308241 ctgaatttaa taaacggaaa attgtttttc atgtcggctc tgtttctcaa attcacagag 1308301 tatcctggga agcgattgaa aagccgacat cgttaaatca aggaatggag cggcacctta 1308361 ccggtattat taagctcgaa gacctgatga tctttttgcc tgactatgaa aaaattattt 1308421 atgacattga atcagattca ggtgttgaca cgtataatat gcataccgag ggcttcgatg 1308481 aaagaagaac tgataaaaag cttatcattg tagaggactc accgcttttg atgcgcctct 1308541 tgcaggatga attaaaagaa gcagggtaca acaatatcgc ttcgtttgaa aatggaaaag 1308601 aggcatatga atacattatg aaccttgctg aaaacgaaac tgatttatca aaacagattg 1308661 atatgatcat cactgatatt gaaatgccaa aaatggacgg acacaggctc acaaagctgc 1308721 tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat tttctcatcg ttaattacgg 1308781 atgatctgcg tcaccgcggc gaagttgtag gcgcagatga gcaaatcagc aagcctgaga 1308841 tcagtgattt gattaaaaaa gtggatacgt atgttattga ataaataaaa acagccgttg 1308901 ccagaaagag gcacggctgt ttttatttta aaagtaactc tcgccaagtt ttttaaagac 1308961 cggtttatgg taagctggct gctggcgatt tggcactagc ggcttttctt tcatgccgac 1309021 atattcttgc aataggtgtt tcgcttttgt taaagacatt tgagctttag gatttcgata 1309081 cgattgatta agtgtaccta aatgcggaag atgttcgaag tcttctttag ttggaggcat 1309141 gtgaaaatag tagtctccga ttgagataag cacgtccgat tgctgttggc tgaaccttgg 1309201 attttttgaa aaatgaagcc ctattttctt tcctttacct tctttgacaa gcttttgcaa 1309261 agcccgtttt ttcagcagat ataggtattt agggttgggg gcggtttttg catggcggtt 1309321 cacagtgtaa actgcttttg aaagattttc tacggttggc tgcagatctt tcgtatatgc 1309381 atggtcgtcc attatttctc tcctttgctc ttatcaattt ctatatgttt agattatact 1309441 tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg cttttttcta agaaaaaaag 1309501 cgcattttta acctgcatta tacagatctt gccttctttt tcggctgttc ttgaaatgct 1309561 tcctgaacat tcacttccac agcctgagca ctgtattttg gcagtgcaat aaaataaaaa 1309621 ataaaaacga gcaggataat aacacccatg ccgtaataaa gataatcaat gtttgaaaca 1309681 aacttaggga ataacagcgc gactaagccg agtgtcaaag attgtgcaaa catcataaaa 1309741 gggtcctgca tgccgcttac acgtcccatc agttttggat gaacaatttt tggcatccac 1309801 cctccgattg caatgttgat cggtccgata cacattccca gtgcaaaagc tgccgcgtaa 1309861 tacacccata aaatattggt gtagccgagg acgaagatca gcaaacctgc aatgaaaatc 1309921 ggtatcgaca ttaaaaagtg cggcttcact tttttagaga tgagcgtgcc gattacgctt 1309981 cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag acgtatgcca ctcataacgg 1310041 tcaggcgcca atccatattt cattgtaaac atcggcaata cggcgaatcc tccattgaca 1310101 aatccaaaaa tgaagaagcc aaaaataaga gatgccagca atttgttttt taaaatatag 1310161 aggatgcctt ctctaaagtc atttattgaa tccttaacag aagtctttct ccagctgaat 1310221 gcaccgtttg gctgtcgggc ttcttttgga atccggcagc tgcggatcag cagcccggaa 1310281 atgataaagc tgacaaaatc aagaataatg gcgccttcaa taccgattgt gttgtacata 1310341 aacgcgccta tgccgactcc aaacaccata aaaatgctaa aaagcatctg attaagccct 1310401 gccgctttcg cataatgctc cttcggcaga atggcttgta ccaaactgtt ttctgccgga 1310461 aagaaaaact ttgttacagc gcttctgata aataagatac aaaaaacaag aggaatattg 1310521 ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg ctctgatcca atcacaattt 1310581 tctgccacct tttttctatc aaaccggtcc gcgacgactc ccacgatcag aaatacaaat 1310641 atggtcggaa gagaatacat cagctccgcc aaggtcgtat atgaaggctg gctgctgaat 1310701 cggtccagca aaaaaaaagc aaaggccatg ttgcctactg tcgtgcccat ttgagaagcg 1310761 agtgctgcga aaaatagacg aacaaaatta cgatttttaa atatatccat aaaaacgctc 1310821 cttaccctaa aggtcccact ttatcatatt ataaaccgcc tgtttttgaa acaaataaga 1310881 aaacattacc ggttaatcgt gactctcgtt ccgtttggca caattgaagc aagttcgatc 1310941 acgtctttgt tatgcatgcg aatgcagcct ttagaaacag ccttaccaat cgaagcggga 1311001 ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc tcagccaata agcgccaaat 1311061 gggccgccgg gattgcgctg gcggttaata atgtaaaact cgccagtagg cgtttgcgtt 1311121 agtattttac caacggcgat gggataggtt ttcattaccc gattatttag ggacagcgta 1311181 agggtcttcg ctccgattga gactgcgata tgatacggaa ttgtataagg gtccggcagt 1311241 ccggggatga ctatggactg tcccgcggtg agccctgcct gcagtgacgg attagcctgg 1311301 agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc tgttcagtgt atcaccttgc 1311361 ttcacctggt acgtaagcag tttcctcatc ctcctttttt acttataagt attgatgagg 1311421 agcccatcct gctacattaa tttgtgcttt ttaaggtgaa gacagtgatt tcaggcttgg 1311481 caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg gtttacgtaa atatgagtgc 1311541 tgcccgtttg atacattccc tctgtgtaga cttttccata tggaggcgta ataatcggtc 1311601 cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc ggaaagctga aggttcacgg 1311661 gataatctgt tgttttcaag gctgcatcag gttcatggac gagaagaatg gaaaaaagtc 1311721 tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt tcccagcatt aagtcatcaa 1311781 gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa tgtttgatag ccattgcgat 1311841 ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac ggcagttcca tagcctccgt 1311901 gatcatgatt gccgtaaata caaagcttgc cgaagggagc attaagcttt ctcaataatg 1311961 gaatgactgc ctggtggtgc tggtacgtat caggattatc aataatatca cctgtaaaaa 1312021 caatgagatc aggtttagat tcattaattg taagaatgac agtttttaaa tcttcgagag 1312081 taaagtaatc actcaagtgt gcatcgctga actgcacgat tttaaaaccg tcaaatccgt 1312141 gcgggatgag agagcttttt attgtgtgtt cggttgtctc gatcatatgc ggctcgagat 1312201 acctggcata gccatatccc ccgccggccg ttaaagcccc ggcagcaaga gcgccgaaca 1312261 ttccttttag aaattgtctt ctggacatct ttttcatttc aaaccaacct ttaatagagt 1312321 ttttctatta tatcatctgt atctgataaa aatctcatat gagcatgtgc tgacagaggc 1312381 agggatataa tgatagaata ttattgaatg aataatcatt cacaattgga gggataaaca 1312441 tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg catgggaaaa gcgatggcaa 1312501 aaaaacaggc tgaattaggg tggcacgtta tggtgacagg gaggaaccat gaggcacttg 1312561 aggaaacaaa aaaagaaatt cagacctttg agggacaggt cgcttgtttt caaatggatg 1312621 tccgttccga ttccgccgct tcagacatga ttaaagaagc ggtaaaagcc tttggccggc 1312681 ttgacgcgct gattaacaac gcggccggaa actttatttg tccggcagaa aagctgacgc 1312741 ccaatggatg gaaagccgtt attgagattg ttttaaacgg cacatttttt tgcagccaag 1312801 cagcggcaag gcattggatt gaccagaagc agcagggtgt cattttaaat atggcagcca 1312861 cgtacgcttg gggagcggga gcgggggtcg ttcattccgc tgcagccaaa gcgggggtat 1312921 tgtcattgac aagaacgctg gccgttgaat gggggagcaa atacggcatt cgtacaaacg 1312981 cgatagcccc cggaccgatt gaacgaacag gcggtgcgga gaagctattt gaatcggaaa 1313041 aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg attgggcaca ccggaggaaa 1313101 tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc ctatataaac ggggattgta 1313161 tcacaatgga cggggggcaa tggctgaatc cttatccgtt ttaatctgaa tatttataag 1313221 tgaatattta agttattaag aacttttatg ttcgaatgta atacctccac aattaacctt 1313281 cttcctatcc aatttgataa cacatagagc tttatttgtt tatgaggtgt tgtgtcatac 1313341 gtaagccacc taatatatga aaggtatatt ttaaaagggg agacgaaata tgaagaactt 1313401 agatttcaaa taaaacattc atataattac ttcgttaact aaaaagagaa attataagaa 1313461 tgaaaggttt caaggttaca tcagattggg aggaaggtaa tataatggac gagatggtat 1313521 tattaactca ggaatggctc aatgaaacgt acaaaggaaa aagtggctac aattccattg 1313581 aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt aactagagca ttacaactag 1313641 aattgggaat tacacagact tccgacagtt ttggtcctac aactttaaga aagcttaaag 1313701 aattaggccc gatttctacg tcaactaatt caaaaaaaaa tattgtgaaa attattcaag 1313761 gtgctcttta ttgtaaaggt tatggtccag gtggattaac gggtacattt ggtcagggaa 1313821 cgaaagaggc gatagcagaa atgcaattgc atatggggct ttctaaaaca gacggtgtag 1313881 taacgcctaa ggtgtttaaa gctttattaa acatggactc ttatatcctt ttaaatgggg 1313941 cgtcagagaa agttcgttca atacagcaat ggctaaataa taaatattac aatagagaga 1314001 atttctactt tatgccctgt gatggcctgt attcaaggga tactcaaaag tctcttgttt 1314061 atgcaataca gtacgaggaa gggttaagtg atagtatagc taatgggaat tttggaccaa 1314121 ctactcaaag attgattcct gtattaagaa ttggagaaac agatgaaaaa aacagtttta 1314181 ttcatttatt tcaagctgct ctaatcttta atggctacaa tgttcctttt gatggagtat 1314241 actctgaatc tgtaagatca aaagtaaagg cttttcagtc ttttgcaaaa ttacaacaga 1314301 gtggtactgc cgactttcaa acatgggctt cacttctagt aagtactgga gaccccaatc 1314361 gaaaaggagt tgcttgtgac tcaattactc aaattacatc ggacagggcg gagtccctta 1314421 agagggcagg ttataagatt gtagggcggt atctaacaaa tgcgccgggg agtacactaa 1314481 ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa atcaggttta aatgtttttc 1314541 cgatttatca aacctatggg ggagcaacaa attattttaa taaagaacaa ggaaagaaag 1314601 atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt taaaaataac actgtaatat 1314661 actttgcagt agattatgat gcatatggta acgatttaaa caacaatatt attccacact 1314721 tcgaaggtat aaatgaaata atgaacggtt ttttaggttc aacttacaaa attggtattt 1314781 atgcccctag gaatgtatgt actatagttt ctaaaaaagg tttagcattt gcaagttttg 1314841 taagtggtat gtctactggc tttagcggaa acttaggata tcctttgcct tacaattggg 1314901 cgtttgacca aatttcaaca attactgttg gaaatggttc tggaatgatt gaaattgata 1314961 atgatatttg ttcaggtttg gataatggag ttaataccat aaatatagtg ccttcagaga 1315021 ataagaagtt ttttgatcaa attgatgttt tatatgaaac tgctgaaaaa tatgctcaaa 1315081 tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt agctaatgag ttggttgccc 1315141 agtatttaag aaaggatgac tacaaagggt ggaagtgggt ccctaccgca ggccagattg 1315201 atcctattta tcgtgaatgg gcagtaaagc gctaggggaa gacctagtaa atggaattgt 1315261 tgatcctata tcaaaaactg tcataggaac gcagcatctt atggcaactt ataatgccat 1315321 tatttatagt ggtggttact ctcaaacact acgagatttt gctggttgga ctggagatct 1315381 attaacaaca atacaggaca tgaaattaca cgctcaagaa tttaattcgc cttatgatgc 1315441 ggctatgaaa ataataggta atatgtatca atttagccta gatgatttat ttagtgatgt 1315501 agatgcaatt aatctagcga ataaaacatc agttggtgct aatgcacaac ctctaaatat 1315561 cgcaattaga gattattata gtaataatga ctgtatgaat aggttcactc aatttgtaaa 1315621 taatagattt gatggttcgt tagacaaaat tttctctgaa gcagagtatt atttaaatac 1315681 aaaccttgac ccagttgttg ttccaattag gttagccttt aaacgtgctt ttgatgttga 1315741 ggattatagt gaagagattg gaaaaataac agcacaagca tttagagatg ttatcgagaa 1315801 aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt aaaactggtc gttcgcttgt 1315861 tttattttct atttaaattt atgatataat ttttaaagat taaggagtga ttcattgaag 1315921 aaattgttaa aaaagttagt tgtattattt ttaagcagtt tagttatcat ctttaatgtt 1315981 tggtacttta ttatttgtgc tttttcccca gagtattatc aaaatacaaa tcttacttct 1316041 aatgaaataa taagatttga aaaactatac cacatagatt ttcctgatga aacaaaattt 1316101 attaaagcta gagagtattt ggctgggccc ggaggagata cgtcagctgt attatatgtg 1316161 tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt acacgtatat gaaaataaac 1316221 tatactgaca atgtcggttc aatgtatgga gttgacgttt caaagagtgt cgccggttta 1316281 acaactctta catttggcac ttacgataaa aaaggaactt tctataatat gaaacatgat 1316341 gatgattgga tgtataaagg cactgactgg aatctttact tttggacagc tgctagttat 1316401 aatgctgtta tttttgtatt tgttttggtt attgtgaaac aaatgaataa aattcttaat 1316461 taaccagtat gtagattgat aatctcaaaa aaattttcct cttcttttaa catactccat 1316521 acgacctact tttccatact atgatttttt tgaaatttgt ggtgtagtta taattgtgcg 1316581 tataatcaga caaagataga gaagcaggtg ataacatgtt ggatccactt gatattttaa 1316641 cgaacattga tgatgtcctt ccatattacc aggcgatttt tagtgccgag gagcagaagg 1316701 ttgtcggata tgaggtgctt ggacgaattt tggcagattc agaaatccaa agtctcgggc 1316761 ccttcttttt agatgcgggg atacccgaag aatataaatt agaggttgat aacagaatta 1316821 tccgccaggc tcttgaccgc tttttagagg cggattctga tctgctgatt tttatgaatc 1316881 aggatgccaa tctgctgatg ctggatcatg gtgaaagctt tctggagctt ctgaaagaat 1316941 atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga aattacagag cacaattttg 1317001 aaggggatat tgagcagctc taccatatgc ttgcatacta tcgtacatac ggaattaaaa 1317061 tcgcagttga caacatcgga aaagaaagca gcaacttgga cagaatcgcg ctgctctcac 1317121 cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc acagccgtca ccgtcatatg 1317181 agcatgtgct gtacagcata tctttattag caagaaaaat cggtgcggcg ctgctgtatg 1317241 aagacattga ggcgaacttc cagcttcagt acgcctggag aaacggaggc cgctattttc 1317301 agggctatta cttagtgtct ccatctgaaa cgtttctaga gagagatgta ttgaaacaaa 1317361 gacttaaaac tgaatttcac caatttatca cacatgagaa aaagaaactg gagaccgtct 1317421 atgagcactc tgaacagttt tacaaacgag tgcatcaggc tgtgacctct ttgagaaaaa 1317481 acaatctgtc ttctgatgat gactttatta aaaagctggc ggaagagctg acagattgca 1317541 gcttcaggat ttacatgtgt gatgaagaag gcgatcagct gacgggaaat gtgtttaagc 1317601 aagatggaga atggatttat cagccggaat atgcggaaaa gaactggagc tggcgccctt 1317661 attttctgga gaacattatg agaatgagaa atctcagaaa aggttttttc agtgatctgt 1317721 acagtgattt ggaaacaggt gaaatgatca gaacgttttc atatccgatg gatgatcaga 1317781 tgtatttatt tatagacttg ccttattctt atttatatga gcaggacgga ctgatttaac 1317841 ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc aaaaaacgat tgacattgat 1317901 actgagaatc attatcattt aattatagag agaagctact ctctgttccc caacccctct 1317961 atcagatcaa gatccgaaaa aacttggcgc tacccccgcc aagtttttta tttgtcaaag 1318021 cataggacaa tccaatgaaa caataaacct aactagtggt aaacgtttaa cacggggaga 1318081 aacattgagt gccgaacacc cctgacactg ctgcacgggt gaggaggaaa attcgttctg 1318141 aaatgattat ttcagttccg ttgtttacct ctatccagca tgactcccat tgattatggc 1318201 cacgcgggac ttcaccataa aattcaaaag aaggttttga caaagttgca aaaaggcatt 1318261 cttaatgctg ccaaagattc gaaaaaaatt ataattatgt gcatgacatt caaaaaaagc 1318321 ctcaaactaa agaaaaatag tttttttcac tttttttctt tgcttaaatt cagcagtgaa 1318381 aatgccatcc tgtccgactt tatggtatga tgctcaatag aacttgtatt ataataaata 1318441 cttgttgatt tgaagttgct ttttgaaagg agtctttttt tagaatgtca caattaatgg 1318501 gtatcatcac acggctgcaa agtctgcaag aaacagcgga agcggctaac gagccaatgc 1318561 agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt taaatatttc gaaaaaaatc 1318621 aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc taacacatat ccgtttgata 1318681 atatcgacat ggtttccatc gaaatctttg aacttcttca gtaagattcc tgaaataggg 1318741 ggaacaagct tccgcctttg caaaagtaat cgaaataaac ggtaaggaac atacttgttt 1318801 catggttgta aatccttgaa aaggagtgtc gtgatggctg attcttttct gttttataat 1318861 ctttcagaag cacagatgac ctttcaagat gtgatggaac ggcttaaagc ctttgttcaa 1318921 aaggaccccc gttcttctta tgtgttatcg atcggaaccg attcacaggt ttaccgcgat 1318981 tacacaaagt ttattaccgc attgcatttg catcgtacag gcaagggagc ttggggctgc 1319041 ttgaaaaatc atacagtcga cagacccata catagccttc gggagaagat ttcgttagaa 1319101 acggcgtaca gccaagaaac ggccgctcat attcttgatg gacacttaat ggatattacc 1319161 gatctgctcc tgccctttac cggtgagggg gcggatctta cctttgaagt tcacttggat 1319221 attgggaaaa aagggcttac aaaagatctg atccaagaaa tgactggacg tattacctcc 1319281 atggggattg aggccaaaat aaagccggat tcatacactg ccttcagcta tgcaaatcgt 1319341 ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc gaattatgcg gttgacgttt 1319401 gttatctgat tacttattct agcggtagag ctgaaagtaa gttgtcttgc tttcagaggt 1319461 attcagtata aaacaggggg cctgattgcg aatgagtctt atcggtgaac gatttacaga 1319521 agaagaacaa aaacttctgc tgaatatcct gatcaaccat gagtatgcca tcgagctatt 1319581 aagcagtgag atcaacgata tagagacagg gaccaaaaac gttgacggaa ccacctacaa 1319641 aaaacttgta acgctatacg accgatttcg atttgaaaat taatgggaca ccctataatt 1319701 gatactccac aaagagtatc ttttttattg aaaggaaact tttcgacaaa tactgataaa 1319761 gtttatatta ttgcaatata gggaatgtat tgatgatgaa aatgaaaagg ggtcgaaaac 1319821 atgataagct tacaatcaga tcaacttctt gaggcaacag tcggacaatt tatgattgag 1319881 gcggacaaag tagcgcacgt gcaagtcgga aataaccttg agcatgcatt attagtattg 1319941 acaaaaaccg gatacacagc catcccggtt ctggatcctt cctaccgttt acatggctta 1320001 atcgggacaa atatgatcat gaacagtatt tttggacttg agcgaattga gtttgaaaag 1320061 cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca ttccgcgcct tcatatcaat 1320121 gatccgatta tgaagggatt cggcatggtc attaataacg gatttgtctg tgttgaaaat 1320181 gacgagcagg tatttgaagg gatttttacg agaagagtcg ttttaaagga attgaataag 1320241 catatacgct cattgaataa gtaggctgta cggtcctatt tttattatat aggcagagtg 1320301 aaaaaagaaa gcgcatacat aatttaaacg agaatagggc ttgaataaga aactaagatt 1320361 ttattagaat gggagataag aaaaacttat tgataacaaa aaggaggacg acatgcagct 1320421 tcaagagctt catatgctcg tagttttagc tgaggaatta aatatgagaa aggcggcaga 1320481 acggcttttt gtatctcagc cggctttatc tcagcgctta caaaccattg aaaaggcgtg 1320541 gggaacaaaa atctttttaa gatctcaaaa aggattaacg gtaacgcccg ccggtgagaa 1320601 aatcattcag tttgcgaatg atgtgacatt agagcaggaa agaataagag aaaatattga 1320661 cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc gtcgcctcca taatcggtca 1320721 gcattggctc cctaaagtcc tgaagacgta tgtggaaaag tatccgaatg caaagatctc 1320781 gctcataacc gggtggagca gcgaaatgct gaaaagcttg tatgaggatc aggttcatat 1320841 cggcattata agaggcaacc ctgagtggaa ggggcgcaaa gattacttaa tgacagatca 1320901 tctgtattta gtggatactg aaatttcctg catcgaagat attgcccata cagaacgtcc 1320961 gtttatccag tttaaaagtg acagcactta ttttcaggaa attcagcact ggtggcatca 1321021 aaaatttaaa acgtcgccga aacagacgat attggttgat cagattgaaa cgtgcaaaca 1321081 gatggcgctg cacggaatcg gttatgccat tttgccgtct gttacccttc aaaatgaaga 1321141 taaagtgaat aaaatgcctc ttttagacat gaaagggcat ccgatcggtc gggatacatg 1321201 gttattaggt tatgagcctg cctttgaact gaaacaagtt caagcttttg tacaagtgat 1321261 aaaggatatg ctggatcagg aaaatccatt ttaaagacag cgaggtgctg tctttttttt 1321321 atttatctgt tgacaatgaa aatcattatc atttaaagtg atacatatga tattgaaaat 1321381 cattatcaac taatggggtg ataacatggc taaagccttg attacatatg ccagcatgtc 1321441 aggaaataca gaagacattg ccttcataat aaaagatacg cttcaggaat atgagttgga 1321501 tatcgattgt gtcgagataa atgatatgga tgcgtcttgt ttaacctcct atgattatgt 1321561 actgattggc acctatacat ggggggacgg cgatttgccc tacgaagcgg aggatttttt 1321621 cgaagaggtc aaacagattc agcttaatgg tttaaaaaca gcctgcttcg ggtctggcga 1321681 ttattcttat ccaaagtttt gcgaagcggt gaatttgttc aatgtcatgc tgcaagaggc 1321741 gggagctgct gtttaccagg aaacactaaa aattgaatta gcgcctgaaa cagatgaaga 1321801 tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca tgggcagatt atatgaacaa 1321861 ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac ggcatcggcg ttttctggat 1321921 attttgtggc ggtacaaaga gaaggcattt ttcattactc tttggagcag ggctggagaa 1321981 agctttttcg tttgaaaagt aagatacact gtatcagcta catagggcct tacttatttg 1322041 gcgttggtga aaagggaaca gtcattcgtt cggctgatga agggaaaacc tggacgatgt 1322101 cgagctttcc gacaaatgca acagtgtggg cgattaccgg cagaaacaac gggtttgtct 1322161 gcgcccacgg taagcattgt atttatgtat cggatgattt tggtgtctca tggcgcgtag 1322221 ccaaaccttt tgccgaattt cataatcccc ctgttatccg gtcgttatgc cttcacgggg 1322281 gcaatctctt tatcggcacg caaatacacg aatattttgg cggcatttgg gcttacgaca 1322341 ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa ccggatgacg gcatccatgc 1322401 tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc tgtgaaagga aagcacggtg 1322461 ctgtcactgt aaggaatctt ttgaatggtg aagaattcac catacaatcc agtatgatca 1322521 gaaatgaaga atcatttctt gatctttcag aggatgatgg cattatatat gtcactacaa 1322581 cacaagatga aaatggtttt tcgagaattt accaggttga tctcgaagcc cggtcgttaa 1322641 aatggttcga taccattaag ggacatggat ggagagtggc caatcagaaa gagaatttct 1322701 tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta cgaagtttca gcaatgattc 1322761 attagaggag gaacaaggaa ttggcgaaga ttttgctcgt ttatgcaaca atgtcaggca 1322821 acactgaagc tatggcagat ttgattgaaa aggggcttca ggaggcgtta gcagaagtag 1322881 accgtttcga agcaatggat attgatgatg cccagctgtt taccgattat gaccatgtca 1322941 taatgggaac ctacacgtgg ggagacggag atctgcctga tgaattttta gatcttgttg 1323001 aagacatgga ggagattgat ttttccggca aaacatgcgc tgtattcggt tccggtgata 1323061 cagcatatga atttttctgc ggagcggttg atacgctaga ggcaaaaata aaagaacgcg 1323121 gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa tccagaaggt gaagaagagg 1323181 aagaattaat aaacttcggg agacaattcg caaagaaaag cgggtgcgct gtctgatcac 1323241 tcactgggaa ctgctaaaac ggctgttcct ttttttcttg tctttgtatc tttcctttga 1323301 tacagtaatg aggtagaaaa tcaggaggag gactatacat atgaaaatga tggacgcaaa 1323361 tgaaattatt tcatttattc aaaatagtac aaaatctaca cctgtaaagg tttacgtgaa 1323421 aggtgagctg gaaggaatca atttcggtga atctgcgaaa gcttttatca atggaaacac 1323481 tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca atcgaagaaa accaaagcaa 1323541 aatcgaagac tatgtggttg aaaatgaccg ccgcaattct gcgatcccaa tgcttgatct 1323601 taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc cgcgaccaag ttgaaatcgg 1323661 tgataacgca gtcatcatga tgggtgcttc tattaatatc ggttcagtca tcggcgaagg 1323721 cacaatgatt gatatgaacg ttgtgcttgg cggacgagct actgttggaa aaaactgcca 1323781 tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg ccatccgcta aaccggttgt 1323841 gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg cttgaaggtg taacagtagg 1323901 taaaggagct gttgttgctg cgggagcgat cgtggtaaac gacgttgagc catacactgt 1323961 cgttgcaggc acaccagcta aaaaaatcaa agacattgat gaaaaaacaa aaggcaaaac 1324021 tgaaatcaag caggaattac gccagctgta aggaaaagtt tgataaaaaa ggcgtggata 1324081 atatatccac gccttattcg tataggcagg aggaatagaa atgaagatag aggagctcat 1324141 cgcaattcgc agagatctgc atcgtatacc ggagcttgga tttcaggagt tcaaaaccca 1324201 gcagtattta ttaaatgtct tggaacaata tccgcaagac agaattgaaa ttgagaaatg 1324261 gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg gaaaaaatgc tggcatacag 1324321 agcggatatc gatgcgcttt ctatagaaga gcaaactggt cttccattcg catcagagca 1324381 tcacggcaac atgcacgcct gcggtcacga tttgcatatg acaattgcac tcggcattat 1324441 tgatcatttt gttcaccacc cagtcaaaca tgatttgctt tttctgtttc agccggcaga 1324501 ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat gtattaaaaa aatggcagcc 1324561 tgatttcatc actgcccttc atattgctcc agagcttccg gtaggcacca ttgcgacaaa 1324621 aagcggcctt ctatttgcga atacatcaga gctagtcatc gatctggaag gcaaaggggg 1324681 acatgcggca tatccgcatt tggctgagga tatggttgta gcagcaagta cacttgtcac 1324741 ccagctgcaa acgattatct ctagaaacac agatccgcta gacagtgctg ttattacagt 1324801 tggtaccatt accggaggct cggcacaaaa tatcattgca gaaacggccc acctggaagg 1324861 cacgatccgc acgctttctg aagaatcgat gaaacaagta aaggaacgga ttgaagatgt 1324921 agtgaaagga atcgaaatcg gattccgctg caaaggaaaa gtgacatatc cgtctgtata 1324981 tcaccaagtt tacaatacga gcggattaac agaagaattt atgtcttttg ttgctgaaca 1325041 tcaactggcg acagtaattg aagcaaaaga agcaatgact ggagaggatt ttggctatat 1325101 gctgaaaaaa tatcccggat tcatgttctg gctcggcgct gattctgaac atgggcttca 1325161 tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca gcggttcatg tcatgacagg 1325221 ttatttttct gtttatgcca attaagtaca aatgaaagaa taaaattcca taaaatgagc 1325281 actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat tggaattgaa caatcgttat 1325341 cagatgtaga agctgcttta aaagaaaaag gatatgacgt tgtaatgatg aaaagccctg 1325401 ctgatgctca aggctgtgac tgctgtgtcg taacaggtct tgataataat gtgcaaggga 1325461 tagccgatac ggtaacacaa gcacctgtca ttacagcttc cgggatgacg gctgaagaaa 1325521 tttgtagcga agttgagagc agaattcagt aataaaaaaa ccgaagcaaa aagcttcggt 1325581 tcttttattt attctgtttc tttagggaaa gcgcggtcga acgcgttctt tatttctttt 1325641 ctcaacactc gttcgactcg ccactgttcc atattttctg ttttggcaat gaccctgatt 1325701 acaatttcag aagtccccag ttcttgaatc ccgatgacat ttgggccttc ttttatttgt 1325761 ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa tatgaatcat ttcatcaata 1325821 tttctttcag ccggcacttt aatgtcaaca agagcctgca tggtaccacg agaatgattg 1325881 ctcacgtttg tgatgtttct gttggggatg taatgcagtg ttccgtcaaa gctgcggatt 1325941 tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa aggtggaaac ggtaatataa 1326001 tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac ctgtcacgat atcactgaca 1326061 agcccttggg cgccaaatcc gacagccagg ccgacgattc ctgcccccgc taaaagagcg 1326121 cttggatcat aatgaaacaa atctagaacc atgacgaaaa atatgaaaat caatgtataa 1326181 gcaaatatgt taagagtcag gcttcggagc gtatgtgcac gtccgataga caagctattc 1326241 tgctcctcga attttgcaaa cagatgttta atgattttca tgcctaatga tcgaacgata 1326301 aaatagagca atatcataat ggcgagttta atgagcagaa caccggcatt tgtaatcagt 1326361 cccgcccaat catattgttt aataaagtcc atgttgagct ccttttctaa ttgattgctg 1326421 cacattgaga ctagttaccc tgtacatgac catgttaaac gttttattca aaaatgtcga 1326481 agccaaagac atacatgatt tgttaaaaat tgactcagga aatctgcttt tatataatgg 1326541 cattgcaata taactaaaaa tggttaatca ccctttattt tcatgcgatt ttgaccttta 1326601 agccaaacaa taaattggag ggatacatat ggcagaacgt atggtaggta aacaagctcc 1326661 tcgttttgaa atggaagcag tccttgcaag caaagaattc ggcaaagtaa gtcttgagga 1326721 aaacatgaaa aacgacaaat ggacagtgct gttcttctat ccaatggact tcacttttgt 1326781 ttgtccgaca gaaattacag caatgtctga ccgctatgac gagttcgaag atcttgatgc 1326841 agaagtcatc ggggtttcaa ctgataccat ccatactcat ttagcttgga tcaatacaga 1326901 ccgcaaagaa aacggtcttg gccagctgaa atacccgctt gctgctgata caaaccatga 1326961 ggtatcccgg gaatatggcg ttttaatcga agaagaaggt gtggctttgc gcggattgtt 1327021 tattattaat cctgaagggg agcttcaata tcaaactgtt ttccataaca acattgggcg 1327081 tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa actggcggac tctgtccggc 1327141 taactggaaa ccaggccaaa aaacacttta attctttcca agaacgaaaa gcggtctagc 1327201 atattcgtta ggcctctctt ttaaaatagg agggaaaaag caatgaaatt acgtcagccc 1327261 atgccggaat tgacgggaga aaaagcttgg ttaaatggtg aagtgacgag agagcaattg 1327321 attggggaaa agccgacgct tattcatttc tggtccatca gctgccactt gtgcaaagaa 1327381 gcgatgccgc aagtgaatga atttcgtgat aaatatcaag atcagctgaa tgttgtagct 1327441 gtacacatgc cccgttccga agatgatctt gaccctggta aaattaaaga aacagctgct 1327501 gaacacgata tcactcagcc gatttttgtt gacagtgacc atgctttaac cgatgcattt 1327561 gaaaatgaat atgtacctgc atattatgtg tttgataaaa caggacagct ccgtcacttc 1327621 caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg tgaaccgcgt tctggctgaa 1327681 acggaatagg tatctgacta aatagtattt cctaaaaacc tgacctcatc aggtttttta 1327741 tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt tttccaaatt tgggtatagg 1327801 aattgatgat ttgtttgatt gatacgctaa aaaacacagc taatttttga tgtttttcct 1327861 caattttaga taaatctcat atctcataac tcgaaaattg tagatattac actaaatttc 1327921 tttaaagaag taagtaaaat atatattttc aacattatac caaataaact agaaagcccc 1327981 ttaatccctt gagaataaag gactcttttg aaaaataaaa cattttcaga aaataaggaa 1328041 tttttcatag agtaaatata atagtaaaat gctaaaataa tagttgataa aattactttt 1328101 gtaatctaat atcttaatta aagatgttaa ttttgatagg gggtacattg aggaatgttt 1328161 aatgaaagag aagctttgcg cttgcggtta gaacaattaa atgaagctga agtgaaagtc 1328221 attcgtgaat atcaaattga acgtgataaa atatacgcaa aattaagaga gctggacaga 1328281 aatggaagcc cttccgaaat caaaaaggat ttccgttctg aaaaaaaacc tgactctctg 1328341 ccggttctcg ctgagcttgc ggctcaggaa atcagaagct atcagccgca atcacagcag 1328401 cagtctgttc agcctcagct tcaatctatt tcctctcttc ctgccggtat accagacgga 1328461 acaacacgaa gaagaagagg aacggcaaga ccgggatcaa aagcagctaa gctgcgtgaa 1328521 gctgctatta aaacattaaa acgccacaac gcggcgatta agagctcgga gcttcaaaaa 1328581 gagattgaaa aagaaagcgg tcttgaaatc cctaatatga caacgtttat gcaaagctta 1328641 attaaaatgt acccggaagt gaaaaagcca tatcgcgggc agtacatttt agagggtgaa 1328701 atcgaatctg cagaatcagc aaacgaataa atataaagaa aaactgcttg gcatcgctca 1328761 agcagttttt ttattgaggt tttttctgtg aaggtttgtt ttctttttca agattaagct 1328821 tatacaccca cttttgataa ggcttttctt cagcggctct gtttttcagc tcttcgattg 1328881 tatggctctt ggcctggtct gatgattggg cgtgggcaag ctgtttttga agcacatgta 1328941 tctgtttggt gacatcttca aggatagtct ctacatgatt tggctgcgcg taggccgctg 1329001 gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc atcaatatcg gcaaaatgag 1329061 aagcaatcca ggcatcgctt tcatcaagtt gccgtttata cgatataata gtttcgtgaa 1329121 ataatttttc tttcgttttt tctatgtcta gcagtctttc tttcgtttct atgattcgat 1329181 ctttcatatg atcaacttct attttaatat gttttagctg atattctttt tctaccattt 1329241 gctcttttag acgcccgttt tcggctttta tcaattcggc ttgctgtttt gcctgaagca 1329301 gtgcattttg ttcctgctca attgaggctt gaagttcgct gatccgttta tgaagatttt 1329361 tattttcttc ttcgattttg actttcgcaa tatgaagttt atgtttttct tcgatttcgg 1329421 ctctgcgttt ataggtttca gcagatagaa gctcctgcaa aacaacgatt ttatcaagca 1329481 gttcagctct tatttggtgc agggtttggc tggtgtggga ggcatgtttt tcttttgttg 1329541 acatatgtgt taattcggca gacagctgct ggagtttttc tttcatatcg gtattttctt 1329601 tgagcagttt gttatttttc tgatgaaagt agcttgcttc aagttcagaa atcagcttat 1329661 ggcaccttga aagctcggat tttaaataaa ggttctcctg agacacgtcg tggaaaaaag 1329721 gacctgatct tttcattcga accatctccc tcatgatgtt aacactacaa tatgcaaata 1329781 ctgaacagct attcctcttt aataaacaga caagcagtag cgttgagcct ttgcttttgc 1329841 tatgctttta acgaaactag aggtgagatg atatgaagca tgtaaacgta ctgctggcag 1329901 ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt caaatggaag ggcaggatgc 1329961 tttacgaatg cgctaaagag gcacttggag aacaaacggt tatcatcagc cgtcccgaat 1330021 ttattgatag atttcaagaa aacggtgaaa atgaagtgta tcaagatgct gagccatttc 1330081 aaggcatggg gccattggct ggtatatata ccgcttttaa aaagacagac ggtgatcttt 1330141 atactgttct ttcctgtgac acaccgctga tacaaagaag gacgatgctg gagctcaaac 1330201 gtctgatgat tgccggtgcg gacgcggtag tcccaatttc agacggacaa gtgcagccat 1330261 tgattgcgat ttaccacaaa cgtatcatgc cagttctata cgatcagctt tctgagaaga 1330321 ggttgagaat atcagattta ttaggcagaa tttcggtttg ttacgtacag gctgaaaata 1330381 tcggagcaaa cccggcagag tttatcaaca ttaatacacg tgatgatttt agctgtttgg 1330441 aagaaaaatc gaactccctc aagcgggact gacggggcaa taacatgata agatgacata 1330501 aaagataagg agaacaggtt tgatggagga acgttattca cggcaaatca gatttaagca 1330561 aattggggaa gagggccaga aaagactggc agacagccat gtgctgattg tcggagcggg 1330621 agcgctcggc actgcaggag ctgaagggct ttcgagagcg ggagtcggta cgattaccat 1330681 tattgaccgt gactatgtgg agtggagcaa tcttcaaagg cagcagcttt atacagaaag 1330741 cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa gagcatctat cagcgattaa 1330801 cagcgagata catattgagg cgtatgttac cgaaggaaca gccgaaacgc ttgagccgct 1330861 gattgaaaaa gcagatgtcg tgatcgacgc gacagataat tttgaaaccc gcatgctgat 1330921 aaacgatctt gcccagaaaa caaagacacc ttgggtctat ggcgcctgtg taagcagcca 1330981 gggaatgttc atgactgtca ttcccggaga aaccccttgt ctgtcttgtt tgtttgagca 1331041 aattcctgtc ggcggggcga cgtgtgatac tgccggcatt attccgcctg ctgtgcatat 1331101 cgtttcagca tatcagcagg ctgaggcatt aaagctgtta accggccaaa aagaagcaat 1331161 acagcggggg tttgtgacat ttgatgtctg gaacaattcg catatgaaga ttaacgttaa 1331221 tcatgtacgc cgtgaggaat gcccatcttg cggagctaat gcggtatatc cttatcttca 1331281 ggattggaac acaccaaaag ctgctgtact atgcggccgt gatacagtgc aggtaaggtc 1331341 agaatcatta aaaagaatcc cgaaacagga gctcattaag cggctgaaaa caatcggcaa 1331401 ggtcgaggct aatgcgtttt tgctgcatat tttttacgag gatttcagaa ttgtcatttt 1331461 caatgacgga cgggcactgg tgcatggaac aaatgatgtg aaagaagcca actccgtgtt 1331521 ggcaagagtg attggactgt aacaacagga ggggtcagaa tgctggagaa aagaacaccg 1331581 ataccggtag acgaggcagt tcggcgtgtc tgccattttc aaaaacaagg tgaaacagaa 1331641 tgggtggcgc ttgaagacag ccttcatcgg tttttagccg aagatataac tgcggatcac 1331701 cacgtacctg cgtttgaccg ttcgccatac gatggttttg ctgtcagagc gtgcgatacg 1331761 gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta ttgaccatat tggagcggga 1331821 gcagtatctg aaaaagaact tggcccgttt caggccgtgc ggattatgac tggcgcgcaa 1331881 atccctgaag gggcagatgc agtcgtcatg attgaactga ctcaagcctt tgaggagaat 1331941 gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg gggataatat ttcaaaaaca 1332001 ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg gcacccgggt gacaccagga 1332061 gtgacggctc ttttggcaac attcggatac gcatctgtgc ctgtcgtgag aaagcctgta 1332121 gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca gtgatccgct ggaaccggga 1332181 aaaatccgca acagcaatgc gagtatggta tatgcgcaag cgatagaagc aggcgcaaca 1332241 ccgctttatt tagggaaaat ctctgatgaa ctggataaaa gctttgctgc agttaaagaa 1332301 gcgatgaaaa aggtggactt cctgatcaca actggcggtg tgtcagtcgg tgactttgac 1332361 tttttgcctg cgatctatga aaaactcgga gcggacgtgc tgtttaataa agttgccatg 1332421 cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata tgctgctgtt tggcctttca 1332481 ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg tcaaaccgat aatccagaca 1332541 tggctgctca atgaaacacc gcattcaatt tgtgcggaag ctgttttgac caaggatttt 1332601 ccgaagccga acccatttac ccgatttgtt cgtgcgctcg tgcaccatca ggaagggaag 1332661 ctgttggcga cacccgttgg cttagataag tcgagctctg tcacatcact tgcagatgcc 1332721 aatgcattta ttatcctgcc gggcggtacg cgaggctacg aatctggcag aacggttcaa 1332781 gtgctgctca tcagagaaga gaatggaagt gaatggcctt ggtccgtcct ttcccgatcg 1332841 tccaagttgt aggatttcaa aacagcggga aaacaacgtt tattgagcgc attcttgaaa 1332901 aagcctctga acagggagtc catttgggct gcctgaagca ccatggtcac ggcggtgaac 1332961 cgcaaacgct cacggaagga aaagacacgg accgttacaa ggcggcaggt gctgatgtaa 1333021 cagcggtaga aggtgctggt gtgttacagc tgactgcccg ccgcaattgg gatttggcac 1333081 ggctgattga gttataccaa tttctcgaaa cagactgtct tctgattgaa ggctttaaaa 1333141 aagcccctta tcctaaagtg gttatcctaa gtgaaaagga agatctggaa gcgctgcaag 1333201 cagtaaatat aatcgccatc atctatagaa aaaaagagca tatgacagag catcagggat 1333261 tacccgtttt tcatgcggat gatccggttg ccgtggattt tgtgctttca cagctgaagg 1333321 gggaatctgc ataatggaac ggtttgagat tacgaaaaca cccattaata ctgaaaacat 1333381 catcaaaaaa gtggagaaac gggaagcggg agccattaca acatttattg gtacggttcg 1333441 ggaatggaca aacggaaaaa gaacggttcg gcttgaatat gaggcatatg aaccgatggc 1333501 cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa aaatgggaag gtgcctcagc 1333561 tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa gcagcggtag tgattgctgt 1333621 atcttctccc catcgaaaag ccgcatatga agccaatgag tatgcgattg aacgcattaa 1333681 acagattgtg ccgatttgga aaaaagaaat ttgggaagac ggtgagcaat ggatcggcga 1333741 ccagctagaa acgacagctt atccgaacgg aaaaccagac ctaagcgagg gagagcagca 1333801 tgattaaaat tcttttattt gcagggcttg ctgaacaggc cggtacacaa gcaatagaaa 1333861 tagatatgga acaagcaacc acagatgaaa taaaagcgag tctaaaagaa caatacggtc 1333921 ttgaatctat tgatacggct atgattgccg ttaacgaaag ctatgtaaaa gaaaatacct 1333981 ctgtatcttc gggtgacacg gtagccatca taccgccggt cagcggggga tgaaaaccgg 1334041 acggcatttc agccgtccgg tttttctgta tttcattggc atatccccaa gtatcctcag 1334101 catacaatga ttttctgtaa gcgtttattc tacatatgtt actccctata aagtaagaga 1334161 ctcactccat aattagactg aaattttgaa aaataataga aatttatttc gggtatcgat 1334221 atagtgaaga tgataaatgt tggaaaggtg ctggatatgg agacatttaa aagattaaaa 1334281 atgtattatt ggccgtacag aaaagtgttt atgtggtcgc ttctagccat gcttttgatg 1334341 actgcaatta ctgtcgttta tccgattatc ctgcaaatta cgattgatga gatcgtactg 1334401 ggacggcagt atcagcttgc ggcgtgggtc agcttaggat ttattgcggt gatggttttg 1334461 aaaggaatgg ctaccttttt tcatcagtat ttaggtgata tgttcgggat caaatccgtt 1334521 tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc tttctttttc ttactatgat 1334581 aacgcgaaaa caggagattt gatgtccagg ctgactgctg atgttgaagg gcttcgtttt 1334641 ttcttatcat acggtctcgc tgagctcatt cgcttcggcc tgctggtagc catcagcctg 1334701 tcggttatgt tttactattc tgttcctctc acgcttgtga caatagctgt tctgccattt 1334761 ctcgcggttg cggtataccg gtttgacaaa agagtccatc ccgccttcag aggcatccgc 1334821 aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata tcagcggcat taatacggtt 1334881 aaatctcttt ccagggaaga ttttcagatc agcactttca ataaagccaa tgcagaatac 1334941 agggcgcagt atttacaaac atcatccatt tggtctgcgt atttcccttt aatggagttc 1335001 attggtaaca cttgtattgt agctcttctc tcatacggcg gttacttggt tatgcaaaat 1335061 cagctcaatc ccggcgagct tgttgctttc ttcagccttg tcaattatat gatgtggccc 1335121 attatgaact taggttttgt catcaatatg ttctctcaag caaaagcgtc aggggaacgc 1335181 ctgctcgaca ttctggaaaa agaagaagac attacagatc atcctcatgc tttgcataaa 1335241 caaaaattaa ccggagatgt ccatttcaaa aatgtttctc ttgcatacgg aaaagaacaa 1335301 acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg ggaaggtaat cggactgttg 1335361 ggcccgacag gttcaggcaa aagctcagtg acacagcttc tcaccagatt ttacagtcct 1335421 gttggcggaa tgattaccat tgatcacaaa cccatcacag attattcgtt aaaaaccctt 1335481 cgctccaata tcggggtcgt acttcaagaa tccttcctgt tttcatctac gattagatca 1335541 aatatttcgt atgggcggcc ggatgcctca atggaagacg tcatcgaagc ggcaaaaagg 1335601 gcgcaggctc ataactttat tatggagctt cctgatgggt atgacaccat gctgggagag 1335661 aggggaatgg ggctttccgg cgggcagaaa cagcgtattg ccattgcgag agccatctgc 1335721 ttgaacccga gcattttaat attggatgat gccacaagcg cagtagatat gcaaacggag 1335781 cacagcatac agcttgcctt aaaagaagtc atgaaaaacc gcacaacctt tatcgtcgct 1335841 caccgcattt cttcactgaa acacgctgat gaaattctcg tttttaataa aggacgcatt 1335901 cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg gctactataa aaagatttac 1335961 gatttgcaat accgtgatgt caaaatgatt aatgagccgc atgaggtcgg atagggaggg 1336021 gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg tttctattac tcttcagatg 1336081 aaatcattga aaagccgttt aactgggctc aaatgtggcg gctgctgagc tatgtcaaac 1336141 catatcgaaa aacaattttg ccgctttctt ttctcactgt attgattggc actgctgtga 1336201 agcttgtgat ccccattttg atcggcgttt atgttcttga tcaagcgatt acagggagaa 1336261 actcggagct gctgattcag ctcattttta ttattagcgg tttatatgtc ctcaattacg 1336321 ccgccaatgt gttaagaatc aggtggatga atcagcttgg ccagcatgtc atttacgatt 1336381 tgcgacagca tttatttacc catgtgcagc gcttatccca tcgatttttt gatcagcggt 1336441 cggcgggatc gatcttagtc aggatcatga atgatattaa ctctcttcag gagctcttta 1336501 caagcggagt catcaatttg ttgaccgact tgctgcttct ggccggcgtg attattattt 1336561 tgtttacgct gagccctgag ctgactatag ccatcatggt gacattgccg attatgtttt 1336621 ttatttcaac aagtctcaga aaaaaaatac gccgatcctg gcaaacggta cggctgaagc 1336681 aatcgaagct caactctcat ctaaacgaaa gcattcaggg catccgggtc acgcaggcat 1336741 ttacgcagga agaagaaaac atggcgtatt ttgacggtgt caatcaggag aactacgaat 1336801 catggcggga agcaactaga aaaaatgcca tgttccgtcc gcttgtagaa atgacgaatg 1336861 cgattgggac ggctgtcttg atttggtatg gagccacact catcatgaat gaaaccatta 1336921 cgattggcgt cttcgtttct tttgctttct atctgggaat gttttgggaa cctatttcga 1336981 gactgggtca ggtctataat cagctgttaa tggggatggc atcatcagaa cggatttttg 1337041 agtttctgga cgaacagcca aatgtcaagg agaagccgaa tgccattcat aatgaaaaga 1337101 taaatgggga gatcagtttt gaagaggttg aattttcgta tgatgaaaaa cgaaaagccc 1337161 ttcacgccgt ttctttctct attcctgcgg gatcgacgct tgcgcttgtc gggcatacag 1337221 ggagcgggaa gacgacgatt gccaatttaa tcagccgttt ttatgatgcg gccggaggca 1337281 ccattaaaat agacggtata ccgattaagg atctttccct tgccagtctg cgctctcaaa 1337341 tcagcattgt cctgcaagat acatttattt tctccgggac catcatggaa aatattcgtt 1337401 ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc gtcccaagcg gtcggagcgg 1337461 atgagtttat ttccgattta gcggaaggat acgcaacaga ggtagaggaa aggggcagcg 1337521 tactgtctgc cggtcagcgc cagctcattt catttgcaag agcattgctc gccgatccgg 1337581 ctattatcat ccttgacgaa gcaacggcaa gcattgatac agagacagaa gtaaaaattc 1337641 agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt gatgatcgct cacagattgt 1337701 ctacgatccg cgacgccgac cgcatcattg ttcttgatca cggcaggaaa atagaagaag 1337761 ggaaccatga tcagctgctc gctaaaggag gcatttatgc cgggcttgtg aaagcgcaat 1337821 acagcacagc gatagaataa tatgaaaagc cttcaatatt gaaggttttt ggaaatttat 1337881 tagaaaaaca tgaaactttt tgatatcctt cccgtactat ttgttagata ttctcaagga 1337941 ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa cggcgactga aaagccttca 1338001 cttttcggag taatcacaag tccgtccgtt caatttgaaa gaataagaga aaggccggct 1338061 gtatggggac cgcttttgat tgttgcagca attatcatcg tcggtgccgt gctgcaatca 1338121 ctcggtacgg attatagtga gcttttgaaa agccaggata cgcaagggct atctgctgaa 1338181 caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa tggcaggcgc tattatcggc 1338241 ggtatcgcag cattatttat tgcccctctt atttattggc tctgtgtaaa agtatcaggc 1338301 ggtgttacga catataaaaa aatgctttct ctcagtctgt ttgtctcttt gattagcagt 1338361 ctcggattat tggttaatgg aatcgttgct tttacgactg acgtgaatcc tctttacagc 1338421 acgacgtcac tcgcagggat tatcccatct gacggggctc tcgccagtgt gttaaatacc 1338481 tttgaaattt tcagcatctg gagctttgta ttattagcaa tcggacttca caaaacggga 1338541 ggcatctcaa aaaaagccgg gtggatttca gcaatcattc tattcggaat tttagttgta 1338601 ttttcgcttt tttcaggttt aatcaattct gtggcgggtg cataagctca tgaaaaaagt 1338661 ctggatcgga attggaatcg cagttatagt cgctcttttt gttggaatca atatataccg 1338721 gtctgccgct ccgacaagcg gcagcgccgg caaggaggta cagacgggga gcgttgaaga 1338781 aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta aaattttcaa atgaacagta 1338841 tgtcttttat gaagcggata aagggacatt agaagacatt aaagtaaagg aaggcgataa 1338901 agttaaaaag ggcacggctt tagtcaccta tacaaatgag cagctgagcc tggaaaaaga 1338961 acagaaccag ttaacgtctg aatccaaccg gcttcaaatt gaccaaattc aagaaaagtt 1339021 aaaagccttg gacagcaaag aaagagaact ggaaaaacag gtaggaaaga aagaagcaga 1339081 aaaacaaatc gaatctgaac ggacagagct tcaaatgcag aaaaaaacag cggagatcga 1339141 attaaaacaa accgagcttc agcggcagtc acttgccaac cgggtgtcag atttagaagt 1339201 gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa gaagcggcat ccaaaaagtc 1339261 agatattcaa gagcctgtca tacatatcgg caacccaaaa gaccttgtcg tctcagggaa 1339321 attgtctgaa tacgatacat tgaaagtcaa aaaaggccag aaggtcacac tcacttcaga 1339381 tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca gtcgggcttg ttccggatca 1339441 gcaggagagc gctgcggcac aaggaacaga acaggcggtc caatacccgc ttcaagtgaa 1339501 aataaaagga aatcttccag aaggaaagcc aggctttaaa tttatcatga atattgaaac 1339561 agataaacgg aaagcaaata cgcttccttc aaaggcagtc aaaaaagaag atgaccaata 1339621 ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt gatgtcaaaa tcggcgaagt 1339681 gacagatgac ctgacagaaa ttaaagaggg gcttacccaa gatgatcaag tcattttgaa 1339741 tccatctgat caggtgactg acggaatgga agtgaaatcc taaatgattc agctttctaa 1339801 tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat gttctccatt ctattgattt 1339861 ggacattcat caaggtgaat atgtctcgat tatggggccg tcaggatcag gaaaatcgac 1339921 gatcatgaat attatcggct gtcttgatcg gccgacttcc ggtacatatc aattggacgg 1339981 cgaagacatt tcttcatata aagataaaga actggcggca gtccgtaacc ggtccatcgg 1340041 ttttgtattt cagcaatttc agcttcttcc gcggctgaac gcaaaaaaaa atgtcgagct 1340101 gccgatgatt tattccggga taggcaaaaa ggaacgtcaa gagcgggctg agagagcatt 1340161 ggaaaaggtc gggttagccg atcgaatgct ccacatgccc aacgagctgt cgggcgggca 1340221 gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag ccgaaattga ttttagctga 1340281 tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg attatggatc agtttacagc 1340341 attaaatgcc gagggaacga caatcgttct ggttactcac gagcctgaag tagcagattg 1340401 cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt cctgccagct ccggacaaag 1340461 gagtgtggga gaatgagcct gttggaaaac atcagaatgg ctctaagctc tgtccttgcc 1340521 cataaaatgc gttcgatctt aacgatgctc ggcattatca ttggtgtagg ctctgtcatt 1340581 gttgtcgttg cggtaggaca gggcggcgag caaatgctga agcagtcgat cagcggcccg 1340641 ggaaatactg tggagctgta ctatatgcct agcgacgagg agcttgcaag caacccgaat 1340701 gccgcagctg aatctacgtt tacagaaaac gatattaaag gtttaaaagg aatagaaggc 1340761 attaaacaag tcgttgcttc gacttctgaa agtatgaaag cgcgttatca cgaagaagaa 1340821 accgatgcta cggttaacgg aataaatgat ggatacatga atgtcaattc tttgaaaatc 1340881 gaaagcggca gaacctttac cgacaatgac tttctcgcgg ggaatagagt cggaatcatc 1340941 tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc ctctaggtga agttgtctgg 1341001 attaacggac agcccgttga aattatcggc gtgctgaaaa aagtaacagg cttgctttct 1341061 ttcgatttaa gtgaaatgta tgtgccattt aatatgatga aatcctcttt tggcacaagt 1341121 gatttcagta acgtatcatt gcaggtcgaa tcagcagacg acataaaatc ggctggaaaa 1341181 gaagcggcac agctggtaaa tgacaatcat ggcacagagg attcgtatca agtgatgaac 1341241 atggaagaga ttgcggccgg aattggcaaa gtaactgcaa ttatgacgac gattatcggc 1341301 tcaattgcag gtatttccct tttggtcggc ggaatcggtg tcatgaatat tatgctcgta 1341361 tcagtcacag aacggacgcg ggaaatcgga atcagaaaat cacttggtgc gacgagggga 1341421 cagattctga ctcagttttt aattgaatca gtcgtattga cgctgattgg cggtctggtc 1341481 gggattggta ttggatacgg aggggccgcg cttgtttcag ccattgcggg ctggccgtca 1341541 ctcatatcct ggcaggttgt atgcgggggc gtgctgttca gtatgctcat tggtgttatt 1341601 ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc ccattgaagc gctgcgttat 1341661 gagtagcctc atgcaacatg catgaggttt ttttatgttt agtgatttct actatgaata 1341721 taaaagactt ttttcattaa aataagaaga aaatgtcgta caattgtcct tatttttgtc 1341781 gaatttacag tttacaaacc ctatagacat acgttaatat ggagaaacgt gaaagatttt 1341841 gatagttatt gaatgaattt gaatgatttt agttgcctaa accgaaaata gcgtttacaa 1341901 tgaaattgta ttcaaaatga atacgttttc attaggaggt gaagcatgct aactcctgaa 1341961 cggcatcaat tgattattga tcaaatagaa aagcatgatg tggtaaagat tcaagagctt 1342021 ataaatctga ctaatgcttc tgaatcaaca atcagaagag atttatcgac ccttgaagaa 1342081 cgcggttttt taaagcgcgt tcatggtgga gcggccaagc tttccgatat cagacttgaa 1342141 cccgatatgc ttgaaaaatc atccaaaaac cttcacgata aactgaagat tgctgaaaaa 1342201 gctgcttctc ttttagaaga aggggattgc atttaccttg atgcaggcac gacgacattg 1342261 cacatgattg attttatgga taaaaccaaa gatattgtcg ttgtcacaaa cggggtaatg 1342321 catatcgatg cattaataag gaaagaaatt tctttttatc tgcttggagg atacgtaaag 1342381 cacagaacgg gcgcgattat tggaggcgct tcattggttg ccatggacca gtacagattt 1342441 gacaagagtt ttctggggac aaacggtgtc catacagagg ctggatttac aacgccggac 1342501 cctgatgagg cccttttaaa acagaaagcg atcaaacagg caaaacacgc ttacgtctta 1342561 gcagaccctt cgaagttcgg agaaatttca ttttcggcat tcgccggaat aggcgacgca 1342621 acaatcatta cgactgacgc tgaagagctt acattcgata attaccaaga aaaaactgtc 1342681 gtaaaggtag tgaaaccatg atttacactg taacacttaa tccatctgtc gattatatag 1342741 ttcacgttga agattttact gtaggaggcc tgaaccgttc ttcgtatgat accaagtatc 1342801 cagggggcaa aggcatcaac gtatcgagac tgctgaaaag acaccatgtg gcgtctaaag 1342861 cgctcggatt cgtcggcgga tttaccggag aatatatcaa aacattttta cgggaagaaa 1342921 acctggaaac agctttttct gaagtaaaag gggatacccg tatcaatgta aagctgaaaa 1342981 cgggtgatga aactgaaatt aacgggcagg gaccgacaat ttcggatgaa gatttcaaag 1343041 cctttttaga acagttccaa tctttgcaag agggagatat cgttgttctt gcaggaagca 1343101 ttccatcttc actccctcac gatacttatg aaaaaatcgc agaggcctgc aaacagcaga 1343161 acgcacgagt tgttctggat atctcaggcg aggctctttt gaaagcaaca gaaatgaaac 1343221 catttttgat gaagccaaat catcatgagc ttggagaaat gttcggcacg gccattacat 1343281 ctgttgagga agccgttcct tatgggaaaa agcttgtaga acaaggcgct gaacatgtaa 1343341 tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa cgaagctgtt tattttgcta 1343401 acgtgccaaa ggggaaattg gtaaactcag tcggagcagg ggattccgtt gttgcaggtt 1343461 tccttgccgg aatttccaaa cagctgccgc ttgaagaagc attccgctta ggagttactt 1343521 caggcagtgc taccgcgttc tctgaagaac ttggaacaga agaatttgtc cagcagcttc 1343581 ttcctgaagt taaggtcaca cgtctataga ggaggaaaca caagtgaaaa taactgagct 1343641 tttaacgaag catacgataa agcttaatat tgagagcaaa gaaaaagaaa atgttattga 1343701 cgaaatggtc actgttcttg ataaggctgg aaagttaaat gaccgacaag cctataaaga 1343761 agccatttta aatcgcgaaa gccaaagctc cacgggtatc ggtgaaggaa tcgctatccc 1343821 ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg ttcggacgtt caaaagacgg 1343881 cgtcgattat gaatcattag acggccagcc ggctcactta gtgttcatga tcgcggcgac 1343941 tgaaggcgca aacaacactc accttgaagc attgtcaaga ctttcaacgc tgttaatgcg 1344001 tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa gatgccatca tcgacattat 1344061 taatcagcac gataaagatg atgacgaaga ggaagaggaa gaagaagcgg caccagcacc 1344121 tgccggaaaa gggaaaattt tagcggttac tgcatgcccg acaggtattg cccatacatt 1344181 catggctgcg gatgccctta aagaaaaagc gaaagagctt ggtgtggaaa ttaaggtcga 1344241 aacaaatggg tcaagcggca ttaagcacaa gctcactgcc caagaaatcg aagatgcacc 1344301 tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa cgttttaaag gcaagcgcgt 1344361 acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa gagcttatcg aaaaagcgat 1344421 gaatcaagat gcgccgattt atcaaggcag cggcggcggt tcagcagctt caaatgatga 1344481 tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac acgttttata agcacctgat 1344541 gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc ggtattctcg ttgcgatttc 1344601 attcttctgg ggaattcact ctgctgatcc gaatgatcct agctacaaca cgtttgcagc 1344661 agcattaaac tttatcggcg gcgacaatgc attaaaactc attgttgcag ttctggccgg 1344721 tttcattgcg atgagtattg cagatcgtcc tggttttgcg cctggtatgg tcggcggatt 1344781 tatggcaact caagcgaatg ctggattctt aggcggctta attgccggat tccttgccgg 1344841 ttatgtcgtg attttactga aaaaagtatt tacgtttatc cctcagtcac ttgatggatt 1344901 aaaacctgtt ttgatttacc cgctgttcgg tatttttatc actggcgtat taatgcaatt 1344961 tgtcgtcaat acacctgtag cggcatttat gaatttctta acaaactggc ttgaaagcct 1345021 tggtactgga aaccttgtgt taatgggtat tatcttgggc ggcatgatgg cgatcgatat 1345081 gggcggtccg cttaataaag cagcctttac gttcggtatc gccatgatcg atgcaggcaa 1345141 ctatgcgcct catgcagcaa tcatggccgg cggtatggtt cctccgcttg gtatcgcact 1345201 tgcaacaacc attttcagaa acaaattcac tcagcgtgac cgtgaagctg gtattacatg 1345261 ctatttcatg ggagctgctt tcgtaacaga gggagcgatc ccatttgctg cggctgatcc 1345321 gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt gccggcggat taactgaatt 1345381 cttccgagta acgcttccgg cgcctcatgg aggagtattc gtagctttca ttacaaacca 1345441 tccgatgctt taccttttaa gtatcgtgat cggtgctgtc gtgatggcaa ttatcctcgg 1345501 tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag cgtccttggt tcgaaaggac 1345561 gctttttctt atccggccgg cagggagcgc ggttaagtta tgtattttat tcttttttat 1345621 gataaagtaa aagaagagaa acaactgaca tagcaattgt ctaggaggaa acactttgac 1345681 cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa aaaaccaata cgtacctgga 1345741 atggggtaaa gcgattgtca tcgctgttct gctggctctc ctgatccgtc actttttgtt 1345801 tgaaccgtat ttagttgaag gttcatctat gtatcccaca ttacatgacg gagaaaggct 1345861 gtttgtgaat aaaacagtca actatatcgg cgagctgaag cgcggagata tcgttattat 1345921 caacggtgaa acttctaaaa tccattatgt aaaaagattg atcggaaagc ctggagaaac 1345981 cgttcaaatg aaggatgaca cgctttatat aaacggtaaa aaagtagccg agccttactt 1346041 gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt ctgacaggag actttggacc 1346101 ggttaaggtt ccgaaaggca aatactttgt catgggagat aaccggctga attctatgga 1346161 cagccgaaac gggctgggac tgatcgcgga agatcgaatt gtcggcacat cgaagtttgt 1346221 ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa cgccttgctg gcctaggaca 1346281 gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat gcataaaacc gtgatgaaca 1346341 ctgaaccgat aatagccagc acactgaaga aaaggtgaac ctgtttgttc tcttttccgc 1346401 gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat gtaaataagg gctatgccta 1346461 tatataagcc gatatctttg gcggtaaagc ctgttacggc aaggtaaaag cccgtaaaaa 1346521 agatcagtaa gcaatattca gtaagtgtta aaagcctcaa cgtgttcctc catgagagtg 1346581 tgtaattttc caggcggatg cattctctct ctttaattgt aacacagctg gctggtttgg 1346641 gtgtataagt gttttctctc tgttttatca gggaatcatt tctcttgccc tgcattcatg 1346701 gtatactttt attgatgata gacatgatgg aggataataa atgattgctg taaataatgt 1346761 aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt aatattaaat ttaccccagg 1346821 caactgctat gggttaattg gtgcaaacgg tgccggtaaa tcaacgtttc taaaggtgct 1346881 gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg agtcctggcg agcgtcttgc 1346941 cgtcttgaag cagaaccatt ttgagtacga agagtatgaa gtgctgaaag tggtcattat 1347001 gggccacaaa cgcctgtatg aagtcatgca ggagaaagac gctatttaca tgaagcctga 1347061 tttctcagat gaggatggga ttcgtgctgc tgagctagaa ggtgaattcg cggaactgaa 1347121 cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa ggccttggta tctcagaaga 1347181 tctgcacaca aaaaagatgg cagacctcgg cggttcggag aaggtaaaag ttctcttggc 1347241 acaggcatta ttcggcaagc cggatgttct gctgctcgat gagccgacga accacctgga 1347301 ccttcaggca attcagtggc ttgaagagtt tctgattaac tttgaaaaca cagttattgt 1347361 cgtatcccat gaccgtcact ttttaaataa agtatgtacg cacattgccg accttgattt 1347421 taacaaaatt caaatctatg tcggaaacta tgatttctgg tacgagtcaa gccagctggc 1347481 gttaaagctt tctcaagaag cgaacaagaa aaaagaagag cagattaaac agcttcaaga 1347541 gtttgtcgct agattcagcg ccaatgcgtc taaatctaag caggctacat caagaaagaa 1347601 acttctcgaa aaaatcacgc tggatgatat taaaccgtct tcccgccgct atccttatgt 1347661 taacttcacg ccggaacggg aaatcggaaa tgatgttctt cgcgtggaag gcttaacaaa 1347721 aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt attatgaatc gagaagataa 1347781 aattgctttc actggccgaa atgaacttgc tgttactacg ctgtttaaaa tcatttccgg 1347841 ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt accacatctc aagcgtattt 1347901 tccaaaagac aacagcgaat atttcgaagg cagtgatctg aaccttgtag actggcttcg 1347961 ccaatattct ccgcacgacc aaagtgagag ctttttacgc ggtttcttag gacgcatgct 1348021 gttctctgga gaagaagtcc acaaaaaagc aaatgtactt tccgggggag aaaaggtccg 1348081 ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt ttaattttgg atgagccgac 1348141 caaccattta gacctagagt ccattacagc gctcaataac ggcttaatca gctttaaagg 1348201 cgctatgctg tttacttccc atgaccatca gtttgtgcag accattgcca acagaattat 1348261 agaaattaca cctaacggca tcgtcgataa gcaaatgagc tatgacgagt tccttgaaaa 1348321 tgctgatgtg cagaaaaaat tgactgaact atacgccgaa taaaaaagca gagatttctc 1348381 tgcttttttt gatacctaaa tgtgaaagga gatcacaaca tgaaattttt ggttgtcgga 1348441 gcaggtggag taggcgggta tattggcgga cggctttcgg agaaaggaaa tgatgtgaca 1348501 tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa ccgggcttgt catccatagt 1348561 gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg ccggagaaac agggcaattt 1348621 gatgtcgtta tcattgcttc taaagcatac tcgcttggtc aagtgataga ggatgtcaaa 1348681 ccatttatcc atcaagaatc tgtcattatc ccttttttaa atgggtaccg ccactatgag 1348741 cagctatttg cggcattttc aaaagaacag gtgctgggcg gcctgtgttt tatagaaagt 1348801 gctttagaca acaaaggaga aattcatcat acgagcgcat cgcatcgttt tgtatttgga 1348861 gaatggaacg gcgagcgtac ggagcggata agagcgcttg aagaggcatt ttcaggtgtg 1348921 aaggctgaag tcatcattag cgggcatatc gagaaggaca tttggaaaaa gtatctcttt 1348981 attgcagcgc aagcggggat cacaacgtta tttcaacgac cgcttggccc aatcctcgcc 1349041 acagaagccg gacgtcacac ggcccaaact cttattgggg aaatttgcac tgttttacga 1349101 aaagaaggtg ttccggctga tccggctctt gaggaagaga gctttcgtac gatgaccagc 1349161 atgtcttacc atatgaagtc ctccatgctt cgggatatgg aaaacggcca aacgacagaa 1349221 ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac gtttatctct cgctgcacca 1349281 gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag cagaaaaata aaaaaaggag 1349341 gcggaaaagc ctccttttat ttacttaaaa agcccaattt ccgtttctga agataggctc 1349401 tcttttcccg tctgccgtaa ttccgtcaat attcatatcc ttagaaccga tcataaagtc 1349461 cacgtgtgta atgctttcat ttaggccttc tttgacaagc tcttcacgag acatctgctt 1349521 tccgccttca atattaaagg cataggcgct tccgatcgcc aaatgatttg acgcgttttc 1349581 atcaaacagc gtgttataga aaagaatgtt tgattgtgat ataggcgaat cgtaaggaac 1349641 aagtgccact tcacctaaat agtgagaacc ttcatctgtt tccaccagtt cttttaaaat 1349701 atcctcacct ttttcagctt taatgtcgac tatacggcca ttttcaaacg tcagggtgaa 1349761 attttcaata atatttccgc cgtagcttaa tggttttgtg cttgatacca ctccgtcaac 1349821 cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc atattggcca taaactcatg 1349881 gccactttca ttcacgcttc ccgcacctgc ccaaacatgc ttcctaggca gcttaattgt 1349941 tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa tgtctctcgt tcaaatggtc 1350001 aactttttca tgaagatttt ggtcatgatt gatccacgcc tgaaccgggt tgtcttcatt 1350061 tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg atcgcttcct cctctgattt 1350121 gccaggaaac accttgtgag cccagcctgc tgatgccgca cctacgacag tccagctgac 1350181 tttgtctgat tgaatatatt gtctgtatgt atgtaatgct ttgcctgctg ctttttggaa 1350241 tgccgcaatc cgtttggaat ctataccttt tagcaagtct gggttcgacg acacaacaga 1350301 aatgaaagca gctccatttt tggcaagctc ttctctgcct tttgcttccc attcaggata 1350361 ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat ttggcgactt cgtcatcctg 1350421 ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg tgttttacaa ttaaacggac 1350481 aaaatcccga acgtctgttg aagcatttac gactacatac tggccttttt ggacattaac 1350541 gccgacttct accgccagct gtgcatatgt atttaatttc tgtgaaaatg aatccatgaa 1350601 tcattcctcc aagctttttt ctcatcatat caaatatgat cctataaagg aaagaaggag 1350661 cccaaagtga aaaacccaaa acgacacgtc ttgggttttt tcaatattat ggatgattca 1350721 gttttacagt gccgcctgca ggcgaatggg gcatatttgc caaagaaatg ctcatgcctc 1350781 caagaataat tccgcttaaa atggctgcga tcgctactct tcttcctaaa tctcttagca 1350841 tctgtttcct ccttaacgtt tctccatttc ccacaatatg aaggaagtga ggaaaaaaga 1350901 agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag actatttaat tgccttttgc 1350961 agcttatcaa tcacttctaa agaacggcct gtgccgattg ctacagattc aagcgggttt 1351021 tgcgccacgt gtacaggcac gacaatctct tctgtgagcc attctttaat tccattaagg 1351081 agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa tatctccgct caattcaggc 1351141 ggacagtcct caagtgtcgc tctgatggct tcaagaatat gcaggaggga ttcacgcatt 1351201 gcatcttgaa tttcgttgga ttgaagcata atggtttttg gaagacctgt cacgaggtca 1351261 cgtccccgaa tttccattgc ctctggtata tgttcaatca gagcatggcc aatttccatt 1351321 tttacctgct cagctgtgcg ttcgccgatc agcaaattgt attttttacg gacgaaagaa 1351381 acgatatcct catcaagctg gtctccgccg atcctgatag aatggcagga aacaacgcca 1351441 ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga tatctactac cacattggca 1351501 accggctcat caaccggtaa atccgctccg atggcggctg caactggctc ttcgattaaa 1351561 tgaacgtttt tcgcgccgca atttttcacc gcatcactga tggcgcggcg ttctactgct 1351621 gttgagcctg atggtgtgca aacgactacg ttcggttttc tgaacgacat gccgatgctt 1351681 tttgcggctt ttttcataat gtgctttagc aggtcagttg tcatatcata gtctgcgatc 1351741 acgccatctt tcatcggtct gacagcgaca atttttcccg gtgttttacc gatcatgttt 1351801 ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg tatccactgc gacaacagat 1351861 ggttcattta ggataatccc tttatttttg ctgtaaacaa gtatattagc tgttcctaag 1351921 tcaatcccga tttcagttga ttgaaacatg ttttcaccca atctctatcc taatttaata 1351981 tgattctaca tttaaagttt ctcagaaata ctgcgatttt tgggggtgtg cgtcggtaaa 1352041 gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa gtaatacatt tttcggtttt 1352101 atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa ctttttcaaa gtttcattcg 1352161 tctacgatat attgaggtac atccttaaaa cattacatga gaaaagaaac atttaaagga 1352221 agaagggttt ttatgaaatc aataggtgtt gtgagaaaag tagatgaatt aggccgcatt 1352281 gtcatgccga ttgagttgag acgggcattg gatattgcca taaaagacag cattgagttt 1352341 tttgttgacg gagataaaat tatcttgaaa aagtacaaac ctcatggcgt ttgtttaatg 1352401 actggagaaa tcacttcaga aaataaagaa tacggcaacg gtaaaattac gctaagccct 1352461 gagggtgcac agctgcttct cgaagaaatt caagccgctt taaaagaata aaattatgct 1352521 aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg ccaatttttg attaccgccg 1352581 cctaagataa gacatcaaga tatttggtaa tgaatgattt gggatacttt acatatttta 1352641 ctcaattatt tgtcgaagaa tggtacaata agtagagaaa cacaagcggc aggtggtcat 1352701 atgagaaaat atcaagctcg tatcatttcc atcattttgg caatgatttt tataatgttt 1352761 tgggattatt tattttattt tataggcaaa aacccgatta attggcctgt tgatattgtg 1352821 tatactgcag tcacgctggt aagtgtctgg atgttggctt attatattga tgagaaacag 1352881 cagctggtta agaaaatgaa ggataacgaa tggaagtata aacagctttc tgaagaaaaa 1352941 aaccgcatca tggataattt gcaggaaatc gtatttcaaa cgaatgcaaa aggtgaaatt 1353001 acatatttaa accaagcgtg ggcatctata accgggtttt caatcagtga atgtatggga 1353061 acaatgtata acgattactt cataaaagaa aagcacgtag ccgaccacat taacacccaa 1353121 atccaaaaca aagcgtcttc tggcatgttt acggcaaaat acgtgacaaa aaacggcacg 1353181 attttttggg gagaagttca ttataaactt tactatgacc gggatgacca atttacaggc 1353241 agcctgggta caatgtcaga tatcactgag cggaaagagg ctgaagatga gctcattgag 1353301 attaatgaac ggctggcgag ggaatcccag aaactatcaa tcacaagtga acttgccgca 1353361 ggtattgctc atgaggtcag aaacccttta acatctgtca gcggtttcct ccagattatg 1353421 aaaacacaat atccggacag aaaagactat tttgacatca tcttttcaga gattaaaaga 1353481 atcgatttag tgctcagcga gctgctgctg cttgcaaaac cgcaggcaat cacatttaaa 1353541 acacaccagc ttaatgagat cttgaaacaa gtcacgacat tgcttgatac caatgcaatt 1353601 ctgtccaata tcgtcataga gaaaaatttc aaagagacag atggctgtat gattaatgga 1353661 gacgaaaatc agctgaagca ggtctttatc aacatcatta aaaacggaat tgaggcaatg 1353721 ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg cctctcatgc agtgataagc 1353781 gtaaaggatg aaggaaacgg catgccgcag gaaaagctga agcagattgg caaacctttt 1353841 tattcaacaa aagaaaaggg cactggactg ggacttccca tttgtttgag aatcctgaag 1353901 gaacatgacg gggaattgaa aatcgaaagt gaagctggaa aaggcagcgt ctttcaagtg 1353961 gttttgcctt taaaatcaga cagctgagag gagaaaaata aagtgaactc gcttctgttt 1354021 gtatacggga cattaagaaa gcatgaaaaa aaccatcatt tgctggcaca atcggcatgt 1354081 atcaatgagc aggcgagaac aaagggaagt ttgtttgctg caaaagaggg gcccacagtt 1354141 gttttcaatg atgaagatga aggctatata tatggcgaag tatatgaagc agatgaattg 1354201 tgtatacata agctcgatca attttttcaa ggatatcata aacaaacggt gtttgtagaa 1354261 acggatgtcg ggattaaaat tgcgcttatt tattttatga acaaagacgg gtgtgccggt 1354321 tttacgaaaa taagcagcgg cgactggaaa gaacatcaga tgatcagcaa atcgaaaaat 1354381 cccatttatt attttgccta tggatcatgc atggataatg cccgctttca aaaagcggga 1354441 gtcgatcact attttcaaga tccagtagga agagctgttt taaaaggata cacaacccgc 1354501 ttcacgctaa aaagggaaga cggttcaaga gcggacatgt tggaagacgg aggaacaaca 1354561 gaaggcgttt tataccgtat cccttattct gctctctcct atctatataa aagggagggc 1354621 gtcgaatctc ttacgtatcg gccggcattt gtagacgttg aagctggcgg aaggcactac 1354681 aaagactgtt taacctttct cgtcctccaa aaagaagcgg aaattgcccc gcctcagcac 1354741 tatcagattg aaatcgaacg cggagcggag ctgtatttgt cgcctgagtt tactgaaaag 1354801 ctcaagcggc atatgaattc gctgccaaaa ggataacact gtaacaaaag aatatgataa 1354861 aatttgatca atatcatgtc atataaagga gcaccacgat gaaaaaagaa tttgcggtaa 1354921 ttgggctggg ccgttttggt ggcagtattt gcaaagcatt aagcgaagaa ggcgtcgagg 1354981 ttatggcaat ggatatcgat gaagataaag tcaacgagta tgccaagatt gcatctcacg 1355041 cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa tttaggcctg cgaaattttg 1355101 accacgttat tgtagcaatc ggggaaaata ttcaagcgag tattttaacg acactcattc 1355161 tgaaagaact tggcgtccat acgattacag ttaaagcgca gaacgattat cacgaaaaag 1355221 tgctgtctaa aattggtgcg gatcacatcg tccacccgga acgcgatatg gcaaaacgaa 1355281 ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt ggagctgtct gaagagcata 1355341 gtcttgttga aatcgtagct aacagccgcc tggctggaaa tacgcttctc gatttagata 1355401 ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag gggcaaggaa gtcatcgtat 1355461 caccgcttgc aaccgaagtc atccaccaag aagatatact cattgttatt ggatcagtta 1355521 cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa atagcagcca aataagccgt 1355581 cctcaaaggg cggtttttca tattatcaga atataacaac tttaatgaac tgagcgtcaa 1355641 tttcttaaaa tttcattgac taagcacagg cgttccgata gcatattgta ccatataata 1355701 aaaaaaggag gggcctattt gaataaagaa gcgctagtca ataggctgaa tgcttcagcc 1355761 aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa tcatggacgt atataatcaa 1355821 gaatggatat atgaagatat tgcgattaca gatggagtta ttgtaggcct cggtgagtat 1355881 gaaggcgaaa atatcattga tgcagaggga caaatgattg ttccgggttt tattgatgga 1355941 catgtacata ttgagtcgtc aatggttaca ccgattgagt tcgctaaagc agtgttgcct 1356001 catggcgtga cgacggttgt tacagatccg catgagatcg cgaatgtgtc tggtgaaaaa 1356061 gggattgagt ttatgcttga acaagctcgg catacaccgc tgaatatcca ttttatgctt 1356121 ccttccagtg tgcctgccgc aagttttgag cgatcaggcg caattctcaa agctgccgat 1356181 ctcaagcctt tttatgaaga agaagaagta ttagggctgg ctgaagttat ggattatgtg 1356241 tcggttcagc aggctgaaaa agacatggtt cagaaactgc ttgatgcccg tgtggcagga 1356301 aaaaggatag acggtcattt agctggttta tcaacagacc tcattaacat ttacagaacc 1356361 gcatttgtct taaacgacca tgaagtaaca tcgaaggaag aagcccttga tcgtatcaga 1356421 aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca aaaacacgct caatgtgctg 1356481 ccggcggtga atgaaaagaa cgcacgccgg ttctttttct gtacggatga taagcatgtg 1356541 gatgatttat tgtcagaggg aagtgtaaac catcaggtga aaatggcgat tcaagccgga 1356601 cttaatccgt ttttagccta tcagctagga agcctcaatg cagccgaatg ctacggatta 1356661 gatacaaagg gagcgattgc cccgggtttt gacgctgatt tgctttttgt atctgatctg 1356721 gaaaatgtca ctgtcacaat gacgatggta aaagggcaga ctgttgctga agacagcaaa 1356781 gcggtctatc aggatcatgc ttcaactgca gcaccagatc aggcactgct tgattctgtt 1356841 aagcttgctg ctcctcttaa caaacaggat tttcatatgc caatcgattc agagcagcag 1356901 atcaatgtca ttcaaatcat accaaatcag cttgaaacac gattagtaca agttccggct 1356961 cctgttgccc gcgaatttga gcctgacact gagcttgatt tgttaaagat tgcagttgtc 1357021 gagcggcata aaggattaaa agaaaccgga cttggtgttg tgaaaggttt tggattcaag 1357081 agcggagcga ttgccacaac catttcacac gactcccata atattattgc cgtcggaacg 1357141 aatgatgagg atatcgcggc ggcagttaat aagctgcagg aaattggcgg aggattaaca 1357201 attataaaaa atggggaaga gctccattca gtaccgctgc cgattgcagg gttattatcc 1357261 gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc ttcatgataa attgtcgtta 1357321 atcggtttca caggcggatt taatccattt ttgacattgt cgtttttagc gttgcctgtc 1357381 attcctgata ttaaaatgac gactacggga ttattcgatg taaaatcatt tcaacacata 1357441 tcactgcaat aaaaagaggc actcccttag ggagtgcctc tttttttaaa cctccataat 1357501 gatcggcagg atcattggac ggcgctttgt tttttcgtac aagaaaggtg caagcgtgtc 1357561 tgtaatttcg tttttgattt cagaccattg agtcgttttt cgttccatta ctttttgtaa 1357621 gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca ccagattctc tcatgtacac 1357681 aaatcctctg gaaatcaaat caggacccgc tgaaatcttg aagtcgtcca tgtcaatgct 1357741 gacaacaacg atgacaagtc cttcttcaga gagaattctg cgatcacgaa gtacgatatt 1357801 gccaatatca ccgataccgc ttccgtcaat gtacactgaa ccggacggga tttttcctgc 1357861 aactgaagcc tcatcgcctt taagtgctaa tacttcacca ttatccatga taaagcagtt 1357921 ttcctctggg atgccacaat ctgttgcaag tttgacatgc atcttttgca ttctgtactc 1357981 accgtgaatc ggcatgaaga atttaggctt gattaaacga agcatcagct tctgttcttc 1358041 ctgtccgccg tgaccggatg tatggatatc gttaagaggg ccgtgaataa cctcagcacc 1358101 cgcacgatac agctggttga ttgttcgact cacgctgatt gtgttgcctg ggatagggga 1358161 tgaagaaaat acgactgtat ccccaggatt gattgaaatt tggcggtgtg tgccgtttgc 1358221 aattcttgat aacgccgcca ttggttcccc ttggcttcct gtacataaaa ttgttacttt 1358281 attagcaggc atacgattga tttcgttatg ctcaataaac gtatttttag gacagttaat 1358341 ataaccgagt gtctgtccaa tttcgatagc cgattccata ctgcgtccaa atacggcaac 1358401 ttttcttcca ttttgtacag cagcttcaat tacctgctgc aagcggtgaa tattcgacgc 1358461 aaatgtggcg aagataattc ggccgtccac cttgcggaaa atgtcatgaa tgctttctcc 1358521 tacacggcgc tcagacatgg taaactccgg attttcactg tttgtgctgt ctgaaagaag 1358581 gcacaaaacg ccttctttac cgatttcggc cattttcgtt aagtttgccg gctcgccgac 1358641 tggagtaaag tcgaatttga aatccccagt atgtacgatg tttccgggcg gcgtttttac 1358701 aacaatgccg taggaatccg gaatactgtg tgttgttctg aagaatgaca cagccgtttt 1358761 gcggaacttt acaatatcat cctcgccgat aatgttcagt ttcgtctgtc tcaataatcc 1358821 atgctcttca agtttattcc gaagtaagcc gatcgcgagt tttccgccgt atacaggaat 1358881 attcacttgt ctgagcaggt atggaatacc gccgatgtgg tcttcgtgcc cgtgggtgat 1358941 aaaaagccct ttaattttat cttcgttttt gactaaatac gtataatcag ggatgacgta 1359001 gtcaattccg agcagttcgt cctcgggaaa cttgatcccc gcatcaatca gtacaatttc 1359061 atcctggaat tgcaccgcgt acgtattttt accgatttcg cccaaacctc cgagggcgaa 1359121 aacagcagtc tgatcatttt ttacaaattt cataccgctc ataactccaa tactttaaaa 1359181 ttttcgctct gttgttcata ttctaagaat gcaccatcaa caggtgtaat aaactcaata 1359241 ttaaatttct tttctttcag ctttgttctg acgtcacgct cagatacgcc ttcaatataa 1359301 agtgaatctg tcttttcccg aacaggtact tcgtcagcct tctcttgata aaatacctta 1359361 taaatcattc caaatctctc cttaaatgcc gtatgttaga ctcgctcatt ctattatatt 1359421 cgaaaacgga atataaggaa agccttgagc aaaataagga tctctcaaaa agtgaaagat 1359481 cccttgtcag gcaattgctt tcttacggag cattccgttc cattgtcttc tgagtttctt 1359541 tcttaattta cgcagcatta gccagtccct cctttaatga aaaatttgtc ccagagttct 1359601 tttatacaaa tagtatacgg agattgagga agacttttcg tggttattaa tggaatttaa 1359661 tatgattttt gaacgaaatt gtttgctgaa tgacaatctt tttgtatgat gagggtggga 1359721 attgcagacc aagacgataa aggggaagtt gcgatggatt ctaaattaat cttttttgat 1359781 attgacggca caatatatga tcatgataag aatataccgg aaagtacgag aaaaaccgtg 1359841 gcggagcttc agcgccaagg gcatcatgtg tttattgcca gcggccggtc tccatttttg 1359901 gttaagccga ttttggagga gctgggcatc cactcattta tttcctacaa tggacagttt 1359961 gttgtctttg aaaatcaagt gatttataaa aatccgctgc ctgaaaatgc aatcaggcga 1360021 ttattaaagc aggcggatga aggcaagcat cctgttgtgt ttatggctga ggacacgatg 1360081 aaagcgactg ttgcggatca cccccatgtt ctcgagggaa tcggcagcct taaaacagat 1360141 tatccagaga ccgatgacct tttttatgaa ggaaaagaaa tttttcagct tcttttattt 1360201 tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg agtttgatct agttcgctgg 1360261 catgagctat cgactgatgt tctgccgcac ggaggttcga aggcagaagg aatcaaaaaa 1360321 gtgattgagc gtcttccgtt tgatatcggc gatacatatg ctttcggcga cggattaaat 1360381 gatttgcaaa tgattgaata cgttgggaca ggcgttgcta tgggaaatgc tgttcccgaa 1360441 ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg aggatggaat tgcatacgct 1360501 gtcaaagaat tgggcctttt aaaataaaga aacggctggc attgtgccag ccgttttctc 1360561 ttttagcgct caattgcgat tgcattttca ggttctttga aaggattttc cttatcaata 1360621 tgatcataga acataacgcc gttcaaatga tcgatctcat gctgaaacac aatagccgga 1360681 aatcctttta aacgaatatc aatattttcg ccttctagtg ttgttccttt tactctgatg 1360741 cgagcatagc ggggaacata accgggaatc gcttcatcca cagagaggca gccctcgccg 1360801 cttgttaagt agcttttttc aactgaatgg ctgacgatct taggattaaa cagagcatag 1360861 ctgtataatt taccggaagc atcttccgca tgaacggcga tcattcgttt tttgatatta 1360921 atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt atttttcggc taattctgga 1360981 ttttggctgt ttttaacaaa ttcgatcatg tcggccagct gctgtttttc tgcatcagtt 1361041 ggaggcagct caacaggttc ggcagtctct ctgagggctg gatggccgtc acgtacgatg 1361101 ttttccatag taatcaagaa acttcactcc taaagcttaa tatgtaaatt atatcggatt 1361161 tcttcacaaa ggtgcaacga aacgaatgac cagccgtata tggctggtca atttcatgct 1361221 gtgtggttag caacagcctc cacctaaata agcagctccg acaatgatta acagaatgaa 1361281 taaaacaacg attagcgcaa aggtgcggcc gtagccatat ccgcagccac catatccgta 1361341 accaccataa ctgcagcagc ctccgccgta accatatcca tacatattac ataacctcct 1361401 cttttaatta cgccagagcc tttataagta ggcatagcgt ctaatataac ctatgtaaaa 1361461 acaaaaaagt tgtatggtca tctgtcctga tttttcactt ttttgattta atttcagtat 1361521 tgcatttata cagcacggct attgccaaat gtccccatgg attctatagt agaaattgtc 1361581 aagattgggg gatttaacgt gaaagacgct ataaaacggc ggcctggaat caagatcgga 1361641 gctttttgtg ccatggcact gatattaaca ggatgcatgg gacaggaccc ggttgattca 1361701 cttcatcatt cattagaaaa agccgcggaa tcggaaaagc cgtttcaaga agaacaaaac 1361761 acactcaaag aattagaggc caaagaaaat cagctttacg atagtgttat gaagctcaat 1361821 atggatgatt ataaaaaaat tgttgcttta tctaataagg cgcttgaaaa tgtcagcaag 1361881 cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa aatcggaaac agaatttgag 1361941 gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca taaaagaaaa ggccgatgcc 1362001 gcagcaaacc atatggagaa aagatataca tcatatggca ctatgtataa agagtataaa 1362061 aaagcgcttg agcttaataa aaaactgtat atgcagctga aagacaaaga tttgacaaga 1362121 gatgatctgg atcagcagat cgataaagtc aatgcttctt atgaaaagat ccttaaatat 1362181 agcggagaat ttaatgaaca aaccgaaaaa tataataaag cccgggaaga tttatatgat 1362241 gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc tctttttttg aatgaaatgc 1362301 gattcggatt tcgttcaaaa ttttcatttc tattgtagta cagcatagta aggtatacta 1362361 gtacagtttt gggtgcggtt ggcatctgtt tttttgatga aaatgtaaag cgaatacatt 1362421 tattgaaaat cagcgatgaa aacgattgac ggttcttctt tatttggtgt aaactaatcc 1362481 atgttaagcg gtgttgtatt agttttttac aacttcgaaa taatacagtt caaagcagag 1362541 tgtaactatc ctacataaaa ggttttggca aactggggat cggctaaaat ataatacgac 1362601 ttactgctga tactttaggg taccctaagt ttgtatgtat aaaaggaatg cacgtctaat 1362661 gactgtttaa aagaaaggaa gaggtgactt agtatggctg caaaaacgaa aaaagctatc 1362721 gttgacagta agaagcaatt tgatgccatt aaaaagcagt tcgaaacgtt ccaaatttta 1362781 aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg atttaactga tgatcaatta 1362841 aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg accaacgctc tatctcatta 1362901 aaccgtcaag gacgtctcgg attttacgct cctactgcgg gtcaagaagc ttctcagatt 1362961 gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc ctggataccg tgatgtgcct 1363021 cagttaattt ggcacggcct tccattatat caagcgtttc ttttctctcg cggacatttc 1363081 agaggaaacc aaatgcctga tgatgtgaat gccctttctc cacaaatcat tatcggtgct 1363141 caatacattc aaactgccgg tgttgcgcta ggtcttaaaa aacgcggtaa gaaagctgtc 1363201 gcaatcactt acactggtga cggcggagct tctcaagggg acttctacga aggaattaac 1363261 tttgccggag cttataaagc acctgcaatc ttcgtggtgc aaaacaaccg ttacgcgatt 1363321 tcaactcctg ttgaaaaaca atctgcagct gaaacaattg cacaaaaagc tgtagctgcc 1363381 ggtattgtcg gcgtacaagt agacggaatg gatccgcttg ctgtatacgc agcaactgct 1363441 gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac taattgaaac acttacattc 1363501 cgttatggcc cgcacacaat ggctggtgac gatcctacta aatatcgtac aaaagaaatc 1363561 gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc gtgcgttcct tgaaaacaaa 1363621 ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg atgcgaaaga agaaattaag 1363681 caagcgatca aaaaagctga tgctgaaccg aagcaaaaag taactgattt aatgaaaatc 1363741 atgtacgaaa aaatgcctca caaccttgag gagcaatttg aaatttatac acagaaggag 1363801 tcgaagtaag ccatggcgca aatgacaatg attcaagcaa tcacggatgc gttacgcaca 1363861 gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag acgttggtgt aaacggcggc 1363921 gtattccgtg cgacagaagg attgcaaaaa gaattcggtg aagaccgtgt gtttgacacg 1363981 ccacttgctg aatctggtat cggcggtctt gcccttggtt taggcttaaa cggcttccgt 1364041 ccggtaatgg aaatccaatt cttcggattt gtttatgaag taatggattc agtttctggc 1364101 caaatggctc gtatgcgcta ccgttctggc ggacgctgga cttcacctgt aacaattcgt 1364161 tctccattcg gcggcggtgt tcatactcct gaacttcacg ctgacagctt ggaaggtctt 1364221 gttgcacaac agcctggtat caaagttgtt attccatcaa ctccttacga tgccaaagga 1364281 cttttaattt ctgcgatcag agacaatgat cctgttgtct tcttagagca tatgaagctt 1364341 taccgttctt tccgtcagga agttcctgaa gaagaataca caattgagct tggaaaagct 1364401 gacgtgaaac gtgaaggtac tgatctttca atcatcactt acggcgcaat ggttcatgaa 1364461 tcattaaaag ctgctgatga gcttgaaaaa gacggcattt ctgctgaagt tgtcgacctt 1364521 cgtacagtaa gcccacttga tatcgataca attatcgcct ctgtagaaaa aacaggacgc 1364581 gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg ctgcaaacgt agtagcagaa 1364641 attaatgacc gtgcgatcct gagcttggaa gcacctgtac ttcgcgttgc agcgccagat 1364701 acagtatttc ctttctctca agcggagagc gtatggcttc caaaccataa agacgttctt 1364761 gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca taatcgagag ggaagatgaa 1364821 cgttttccct ctattatata tctgttttca atgcttacga tgtaaacttt aaaattgctt 1364881 aatcaaacta ggaggtcgag aactgtggca tttgaattta aacttccaga tatcggggaa 1364941 ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc ctaacgacga ggtagacgaa 1365001 gatgatgtac tggctgaagt ccaaaatgat aaagcagtag tagaaattcc ttcacctgtt 1365061 aaaggaaaag tattagaatt aaaagttgaa gagggaacgg ttgcaactgt tggacaaacg 1365121 attattacgt ttgatgcacc tggttacgaa gatcttcaat ttaaaggcag cgacgagtct 1365181 gacgatgcga aaactgaagc acaagttcag tcaactgcag aagctggaca agacgttgcg 1365241 aaagaagagc aagctcaaga gcctgcaaaa gctactggcg caggacagca ggatcaagct 1365301 gaagttgacc cgaacaaacg cgtgatcgct atgccttccg tacgtaaata tgcacgtgaa 1365361 aaaggtgtag acatccgtaa ggttactggt tcaggcaaca acggacgtgt tgtaaaagaa 1365421 gatatcgaca gctttgtaaa cggaggagcg caagaagctg caccgcaaga aacagctgca 1365481 ccacaagaaa cagctgctaa accggctgct gcaccagctc cagagggcga attcccagaa 1365541 acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa aagcgatggt taactctaaa 1365601 cacactgctc ctcacgtaac gttaatggac gaagtggacg taacaaacct tgttgcacat 1365661 cgtaaacagt tcaaacaggt tgctgctgat caaggaatca agctgactta cttgccttac 1365721 gttgtaaaag ctcttacatc tgcactgaaa aaattccctg ttttaaacac gtcaattgac 1365781 gataaaacag atgaagtcat ccaaaaacat tacttcaaca tcggtatcgc tgctgacact 1365841 gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc gtaaatctgt ctttgaaatt 1365901 tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag gcaagcttgc tccagctgaa 1365961 atgaaaggcg catcttgcac aattacaaac atcggttctg ccggcggaca atggttcact 1366021 ccggttatca accatccaga agttgcgatt cttggtatcg gacgcattgc agaaaaagcg 1366081 attgttcgtg atggcgaaat cgtagcagct ccagtcttag ctctttctct cagcttcgac 1366141 caccgtatga tcgacggagc aactgcgcaa aatgcattaa atcacatcaa gcgtttactg 1366201 aacgatccac aattaatttt aatggaggcg taatgttatg gtagtaggag atttccctat 1366261 tgaaacagat actcttgtaa ttggtgcggg acctggcggc tatgtagctg ccatccgcgc 1366321 tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca actcttggag gcgtttgtct 1366381 gaacgttgga tgtatccctt caaaagcgct gatcaatgca ggtcaccgtt atgagaatgc 1366441 aaaacattct gatgacatgg gaatcactgc tgagaatgta acagttgatt tcacaaaagt 1366501 tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc ggtgtagcag gtcttcttaa 1366561 aggcaacaaa gtagatgttg taaaaggtga agcttacttt gtagacagca attcagttcg 1366621 tgttatggat gagaactctg ctcaaacata cacgtttaaa aacgcaatca ttgctactgg 1366681 ttctcgtcct atcgaattgc caaacttcaa atatagtgag cgtgtcctga attcaactgg 1366741 cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt atcggcggcg gatacatcgg 1366801 aactgaactt ggaactgcgt atgctaactt cggtactgaa cttgttattc ttgaaggcgg 1366861 agatgaaatt cttcctggct tcgaaaaaca aatgagttct ctcgttacac gcagactgaa 1366921 gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct aaaggcgttg aagaaagacc 1366981 agacggcgta acagttactt tcgaagtaaa aggcgaagaa aaaactgttg atgctgatta 1367041 cgtattgatt acagtaggac gccgtccaaa cactgatgag cttggtcttg agcaagtcgg 1367101 tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa cagtgccgca caaacgtacc 1367161 taacatttat gcaatcggtg atatcatcga aggaccgccg cttgctcata aagcatctta 1367221 cgaaggtaaa atcgctgcag aagctatcgc tggagagcct gcagaaatcg attaccttgg 1367281 tattcctgcg gttgttttct ctgagcctga acttgcatca gttggttaca ctgaagcaca 1367341 ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc ccatttgcag caaacggccg 1367401 cgcgctttct cttaacgaaa cagacggctt catgaagctg atcactcgta aagaggacgg 1367461 tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct gatatgattt ctgaattaag 1367521 cttagcgatt gaaggcggca tgactgctga agatatcgca atgacaattc acgctcaccc 1367581 aacattgggc gaaatcacaa tggaagctgc tgaagtggca atcggaagtc cgattcacat 1367641 cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag cgagggctgt ttttttattt 1367701 tgacagcaca tgctgtaatg gtttaatgat gtcttctttc tttttcacac atccctcgat 1367761 tttcaccacg acatggcgct gatcaacaac cataagggta gggacagttt caatctcatc 1367821 ttcccagcct tcttttttat catagacctt cattttatct atttgctcgg gataatcttt 1367881 ttctaaatca agcagtgcat cgtaataagg cgcttcctgg tctatttggt tctcatcaga 1367941 aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg ctttttttca tcggattgat 1368001 ggtggaaagc gtacagcccg ataaagcaaa tactattatc agcatgggga ataccgcgcg 1368061 atatcgcatc tatcttctcc tctgtataaa cagtagttaa ctagctttag tttatcacga 1368121 gagacggctt aatctgcttc ttgttaccta attgttatat aattgaaacc gtttttaaag 1368181 tgagattaca tattatatca atcgtttaaa atagcaacct ggggtatatt gaattttttg 1368241 ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac attatgtgct gtggcatata 1368301 tatcgagtaa agcttctgta tgaagaagat attgtatgat ggaaaatgga aaaacaaggt 1368361 gaatatgatg atatgaaata aaatgtgtta tacagtttgt tgttgacatt ttaaatgtga 1368421 catattaata taataacaac aaaagaaatt aagcgttttc aaatttcaaa gaaatgggga 1368481 ataagagatg ggtacgattg tttgccaaga ttgcaacgaa gccattcatt actttgaaga 1368541 tgagaaagtg acaacattat atggaacttg ctgcggacaa tgtcaatgtc ctgttgatga 1368601 agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt tattttttat tgaattgctt 1368661 tttgttcttt gatgacccgg atcatatgta aagtcgagtc ctcaggtcct tgaacaggga 1368721 ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc ttctgtaata atttctcctg 1368781 ggatgaagat tggaatacca ggcggatata ccatgacaaa ttcagcaata atccgtccgg 1368841 atgcttcttt taatgggatg acttccgtat ttgcatagaa agcatcacgc ggagtcattg 1368901 ccaataaagg tatttctgga agcagaacct cagtttgctg atgtgttaca tcttgttctg 1368961 acatttgctg tgcgatctca gttaaagcct ctacaagccg gtctgcatca ttttggctgt 1369021 caccaggagt gaaaatacac aaaatattgt acagatcaga aagctccacc tcaatattaa 1369081 aggattcacg aagccatttt tccacgtcat gtcctgtcag gccaagactt ttcacagaga 1369141 taatcaattt tgtcggatca tagctgtaag ctgctttcga cccaagaatc tcagaaccga 1369201 cacaataaat gccttcaatc tgattgaggc gatctctcgt ctgattggca agcttgagtg 1369261 tttcctcagc aagctggcgg ccttctgttg caaggcgttt tctggcaaca tccaaagaag 1369321 cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct caggatggat tgcactctgt 1369381 ctttagatac aaggccttct ctcatgttta aaatagagct ttgtgtcagt gatccgccca 1369441 gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg catagccgat agcggcaatt 1369501 cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac aagcactggc acatcaaacg 1369561 aatgagcgag ttctacgatg ctttttaagt cggctgcaac accgaaatat gtcgggttga 1369621 tgacgagaag cccttttgca tccggatgct cggtaagcgc ccgtttagca gattcaagtg 1369681 taattccgtg ggagatgccc aattcattgt caatttcagg atgaataaaa attggaaccg 1369741 ctccggaaaa tacaatagct gtcataattg atttatgaac atttcttgga ataataattt 1369801 tatcaccagg tccgcaaaca gccattacca ttgtcataat ggcgccgctt gttccttgaa 1369861 cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc cagatcttgt gcttgtttaa 1369921 taatgccttt tggcgcgtgc agatcgtcta atggttcaat attaatcaaa tctatgctta 1369981 acgcgttttc accgataaat tgtctgaatt ctgggtccat tcctgcccct tttttatggc 1370041 cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt tttcagtcct gtgtataagg 1370101 gtgtttcatg ttgcgacaat tgttttccca cctttgtaat catacctatg cataatagtg 1370161 tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa acaaatgaat tatattatga 1370221 acttgaaaga atgtaaagct agacaaaatt gatagtattg tcctgtgttt gtttttgttg 1370281 aataatatca agatgagtca agtgtcatgt ggtggttcat tcaagagtta tgttttttac 1370341 atatcaaggg gaagatgaga tatttttgtt tcatcttgaa actttttgaa aagtccgctg 1370401 tctaaccgaa tgaggcctta ataagaagta aaggattgtt gttcgtgttg gagttattca 1370461 gtcattatgt attgcatttc gaacgttatt ttatattaag cagacaaagc accctgctga 1370521 ttcaatggtc aattgttgtt ctggcgggct tatatctttt ggtgcatcat cccaaaataa 1370581 accggcagcg cacaatgttc ttggcgggtg ttatattgcg gattgtgctg ctggcgggag 1370641 tgtctgttga acttattcac caggtgcaat caacaaactt caccagcgct tacttaagag 1370701 aggacggaaa agaactgctg ccgctgctgc attttttgtt atacggatat gtgctgctga 1370761 cggcttttca ctatatgctg atgccgcgtg atcatggcgg aaagggtaag ttttatacgt 1370821 tcgaccttgc tgttgtcagt ttgccgatcg tacaaatgat ttttagtttc ttttcgtatt 1370881 ggaaggaata cccggatggg atggagccga ttgcattcgt gtttctgttt ttcatcatca 1370941 ctcttcccat tgcgttgaat gtagtgtttt tcaagctgta ttggagaacg gataagatct 1371001 tactaggctt attttatacg ctgattatcg gactgcttgt cttgctgctt gcgccatatc 1371061 ccaatcaaat ctcaaaagat tatggtgcag taatgccata tacgatttat ttggcaatgg 1371121 cgggattttt gatgagctat catctgttcc aaaagtcagg aaaggtttat gtgcgtgtga 1371181 ataagtgggt gacgatggct gtcatggtgt tttttgtcct gctgttaaat ccgatatata 1371241 acataggaac ggctgctttc gctgtatcaa agccagcaaa tgtccatgat tcattcaatt 1371301 ttgtcgggga gcacatttca tcagaaaaag cggaacagat actaaagtca ttttttccta 1371361 cggatgaaac actttatttg cacgatacaa acatggatgt gcattatttc tactcatttg 1371421 aaagcaaagg ttacaaagct gaggtagatg aagtatcgca gctaattcgt aattatgaat 1371481 acttacaaaa agcacatggg aaaaagctaa cgaatcagga gtacaagcga aagtccatcg 1371541 ctttccttga gcgacacgga cgtgtgttac ataaggatca tatcgaaaca aaggtatctc 1371601 aagaagacgg ccagacagtc gtacgtattt acctgaaaaa tcaacttcat aaaaaagatc 1371661 atgctgatga tggcgcggta ttttattggg aaaaggaaac cttaatgggg tttagtgaag 1371721 atccttcgat ttatcagctt gactctcttc tgcatgttca tataacggaa caagacattc 1371781 acgacaaagt ggaacaaatg tttacagcgc tgaacatatc aaaacagcct tatcagatca 1371841 ctgatattga aagcgacagc ctgcttggaa gcatggtgag agttgaaaca aaagttggaa 1371901 ttgttttgga atttgagggc gaatcaggtt gtttacatag tctttcgctt ccgatgaaaa 1371961 agaatatctc aatggctaac agccggctgc agcatcagat attatcgatc ttcgatgctc 1372021 gtggatcaga aaagaagaaa aaaagcagtc agggtgacat ggtgatgtat actgattctt 1372081 ctaaaacata tgagtttgtt gaagctcaag gtcagctaaa cgtttatgta tacagcgata 1372141 cacctgatca gtcattcccc tatacgtatc gtaatggaac attggcttac gaaaaagtag 1372201 cttctctata tcaggatgtc atttacaaaa agcgtatgcg tccgattatc gttcaaagag 1372261 gggatgaacg gcattatgca tggctgatca ttattcagcc gtttggttca aatcgccatg 1372321 atgcctatgt agtggatgga gaaacacaag aggtgaaaag tctttatgaa tcataaagaa 1372381 aaagagtctg tttttgtaga cttatacgac ctgtataaag aaggagagct agaggatgaa 1372441 tcaatggaat ggatgaaaca gcatgaatcc ctatttcaaa agaatgcgga agacttaaag 1372501 agtaaaactt gtttaaagag aagtcccggt gctgaagaag aaagccaaat cagatatatg 1372561 aaagtatacc tgtcttccat gtatatctgt ttcattttat tggccatttg gatgacggtg 1372621 tggttttatt tttaatgaag catagggatt ccattgagga cttgtatcgg cagtattatc 1372681 aagaaatttt aaattattta ttcagaagga ctcatcatct tgaaacagcc aaggacttag 1372741 cgcaggacac gtttgtaaaa gctcttaacg gtctggcttc gtttaggggg cattcttcca 1372801 tcagaacatg gctctacacc attgcgcatc atacctttat caattggtac cgaagggatg 1372861 tcaaatacca atttactgaa atcagcaaaa atgaagggtt aacgcaaaca acttatgacc 1372921 agcctgaaca gtatctgtca cggacggtga aaagcgaaac actgcggcag gagctcctga 1372981 agttaaaaga tcagcatcaa tccgttttga ttttaagaga attccaagag ctttcttatg 1373041 aagaaatcgc tgagatatta ggatggagtc tttctaaggt gaataccaca ttgcaccggg 1373101 ctagattaga gctaaagaaa aacatgacga aaagtagaga ggaggagcgg atatgacctg 1373161 ctttctagta agagacctgc ttcctctgta tcttgaaggt gattgtaaaa gagaaacgga 1373221 acacgttata gaagagcatt taaaaatgtg cagcagctgc agagacatgt atgacacgat 1373281 ggctgagcca tttgaattgg aaagcgaaca ggccgttgag gaggcttatc tgccggaaga 1373341 agaactgcgt tttaaacaga ggtactatgg attactgatc atgaaagctg cctgctggtt 1373401 tggagcggcg gttgccatga tgctgatcat caaactgctg atataaaaaa agcgcttgtc 1373461 cgattccggc aagcgctttt ttacattaag cctggggatg aatcatatcg taaatagcgg 1373521 caagctgttc ttgtgacagg gcactgaaga gtttttcata aacgtcagct tgcagtggcg 1373581 ttgcacctgc ttgtagcgct gcgtctttat catagctgta cacatcatct tgtagcacaa 1373641 tggctgcttg aagaatgtga atcttgagag aaacagcgga gaaaaattgt tcaagtgcaa 1373701 gtgcttcttt ttctgtgaag ccaagttcaa ctgctttttc tgtatcaaat ttgtaatttc 1373761 catcctcgag atacacacat tgtgaaacaa tgctgaaaaa ttctgatgtc gattcccaga 1373821 gtgtagcaat tacctgagcc tcttcttttg tcattcctaa ctcgacagct ttttcgctgt 1373881 caaaataata tacaccgtct tgttcgtata tacattgatt taatatatca atgaatgtat 1373941 tgagatcttc gttagtgctc gcctgatgct ggagttgaac agcagtgtta tcaaccggtg 1374001 tttttgcgct ggctgcatca ggaccgaacg ttaatagagc agctgaggtc attgcggcag 1374061 tcgttaacat agcttttttt acaaatgttt tcttcatgtt tcttctctcc cttttatgaa 1374121 ttgtgctaca aattccatta tagggagtag tttccggtgg aggaataggc gctatggtat 1374181 tttatgtgta tcgttgccga actacttttt gaaggctgca cgtgtgatcg ttagaacgat 1374241 tgtctatgta tgaaggctgt tttgcatctt cctgactaag aaacagggga gataaggctt 1374301 aaagaaatga aaaacaccgc tttctttgcg gtgttttttg attacaatgt cgccggcggg 1374361 gcaatgcttt taatcaagca agccttgttc gcgcattttc ttttttaatg taaatccgcc 1374421 gcccatgaca gcgcaaacaa gtacaatgct ggcgataatg cctgcagggc ttttttcagc 1374481 gataaagacg ccgatcagca taatgctgaa aaccgctgca aatgcaaata atagtaaaag 1374541 ccaattcatt tttttcataa attccatccc cttttacgtc ttatattaag tttacagaaa 1374601 aacgtgacgc ttttaaagag gatgtgtgat ataatatgaa agttatctaa tttttttagg 1374661 agatgaaaaa gtgaaacttc gaaatgatct tcgcaacatc gcgattattg cccacgttga 1374721 ccatgggaaa acgactctag tcgatcagct tttacatcag gctggtacgt tccgtgccaa 1374781 cgaacaggtt gctgaacgcg caatggactc taatgatctt gaacgcgaac gcggcattac 1374841 aatattggcg aaaaatactg cgattaacta taaagataca cgtatcaata ttttggacac 1374901 ccctggacat gcagactttg ggggagaagt agaacggatt atgaaaatgg ttgacggcgt 1374961 agtgcttgtc gttgacgcat atgaaggctg tatgcctcaa actcgttttg ttctgaaaaa 1375021 agctcttgag caaaacctga accctgttgt tgttgtaaac aaaattgacc gtgactttgc 1375081 tcgtccagag gaagttatcg atgaagttct ggatctgttc attgagcttg atgccaatga 1375141 agagcagctc gagttcccag tggtatatgc ttccgcgatt aatggaacag cgagtcttga 1375201 tccgaaacaa caggatgaaa acatggaagc tttatatgaa accattatta agcatgttcc 1375261 ggcacctgtt gataatgcag aggagccgct tcaattccaa gttgcccttc ttgactacaa 1375321 cgactatgta ggccgtatcg gaatcggacg cgtattccgc ggcacaatga aagtcggaca 1375381 gcaggtttct cttatgaagc ttgacggaac ggcaaagtca ttccgtgtta caaagatttt 1375441 tggtttccaa ggcttaaagc gtgtggaaat tgaagaagca aaagcgggag acctcgttgc 1375501 ggtttccggg atggaagata tcaacgttgg tgaaacggta tgtcctgtag accatcaaga 1375561 tccgcttccg gtccttcgca ttgatgagcc gacacttcaa atgacatttg tcgtgaataa 1375621 cagtccgttt gcaggccgtg aaggcaaata tgtaacggcc cgcaaaatcg aagagcgtct 1375681 tcaatcacag cttcagacgg atgtgagctt gcgtgttgag ccaacagctt ctcctgatgc 1375741 ttgggttgtt tcaggacgcg gtgagctgca cttgtcaatt ttaattgaaa atatgcgtcg 1375801 tgagggctat gagcttcaag tgtcaaaacc tgaagttatt atcaaagaaa tcgacggcgt 1375861 acgctgtgag cctgttgaac gtgtgcaaat tgatgttcct gaagagcata ctggctctgt 1375921 aatggaatca atgggtgccc gcaaaggcga aatggttgat atgatcaaca acggaaacgg 1375981 ccaagtccgt ctcatcttta cagttccttc ccgcggattg atcggttact ctacagaatt 1376041 cctatcatta acacgcggat tcggtatttt gaaccatacg tttgacagct accagccgat 1376101 gcaggcaggc caagtcggcg gacgccgtca aggtgtactt gtgtcaatgg aaaacggaaa 1376161 agcaacatca tacggtattc aaggaattga agaccgcggt gtcatcttcg ttgagccggg 1376221 tactgaagta tacgaaggaa tgatcgttgg agagcataac cgtgacaacg accttgttgt 1376281 taacgtcagc aaaatgaaac agcaaacaaa cgtccgttct gcgacaaagg atcagacaac 1376341 tacaattaaa aaagcgcgca tcatgtctct tgaggagtct ctagagtact taaacgaaga 1376401 tgaatattgt gaagtaacac ctgaatccat ccgtttaaga aagaagatcc tcaataagaa 1376461 cgaacgtgaa aaagcagcta aaaagaaaaa aacagcagga ttgtcttaat ctcgtgcaga 1376521 atttgaaaag atagaacccg tacgtttaca ggggagggaa tctttttgaa tgacgtaagc 1376581 gaacgcctgt cgttcttcgc cgctctatat caagtagacc ggcagcctgc ggcaggcatg 1376641 tggctgctgt acggcacgat ttttgtgttg gccgttattg tatttaagct tggatttgct 1376701 aaacggcttc ctgtattaaa atctgcagtg gtgtatgtat ttttggcttt gggctgcact 1376761 gttttgactt ttttaggggt gtttttgccc gtggcagaag gattggtcgt cgctgcgctg 1376821 attttaatca tttacaaaat ccggctgtat cagtcgaaaa aaggacagtc tgcaaaatca 1376881 taaaagactc agctgaaagc tgagtctttt ttgtgttctg tatggttaag cggccgcttt 1376941 attttttgac tttttctttt ttctgctgtc ccgggtgaaa agtaaatttt cccgttttca 1377001 gccgttcctc tgtttttttg gcaatccgat cgtggcattc ctggcacata tatgtatgga 1377061 tcgggcggtt tcgaagccgt ttcgcgatca gggtatcatc atcaattgtt tcaattttat 1377121 cgcaaataga acatttgacc ctcatcatat cacctctttc actaacatgt attataccac 1377181 ggatcagaag ctgtccaaaa taagaaaaag ctaaagcgca aggctatagc ttagtcattg 1377241 ttgttctttt tcatatgatg atcagattga tcgttttgtt ccttctccat ttcctgttgc 1377301 tgttttctat ttaattggtc attttgctgc tttgtttgcg gttcatcttc attgtcaatc 1377361 acatcgttag gcacttcggg aagcactcgg ccgacaattg cagctaattc atccagtata 1377421 cctgttaccg gatggccctc gctgatttct ctgctcattt cgcgaaggcg gctgaccgta 1377481 tcgggatcag caatgactac tgcgttggcg ccatatcgat cattctttag cgcctgagct 1377541 acagaatatt taatggtttc cactttgctt ctgtccaaag tatcatcgac atcaatccca 1377601 acaacagcat agcctcccag cacaacggct gttgcatcct tgacgtcggg gtttttttca 1377661 gcaacgctga caagatgctt ggcaatatcc gttcttgttc cattgtcttt tgtttcttga 1377721 gttgtgtcct ttacgtgaat cggtttagtc tcctgctgtc ttgttgattc tttttcaaca 1377781 ttctggccct gttttccttg ttgataggca caagcggaca ggataagtgt cagctgtatg 1377841 ataatgaaaa gaattcgcac ttgcgggttc cctccttaaa atgctttcat taattttatt 1377901 gttgaattaa ccttctatct ttatgcacaa aaacatatat tttagcaggc attcaccttt 1377961 ttcatcaaaa gagaagcagg aagaactttg acccttatat caggaggctg agacttgagt 1378021 aaaatttatg tgttagatac gaatgtgtta ttacaggatc ctaacgcgat attttctttt 1378081 gaagaaaatg aggttgtcat ccctgctgtc gttttagaag aggttgattc aaaaaaacgg 1378141 tatatggacg aagttgggag gaatgcaagg cacgtatcta agctaatcga tgcgctaaga 1378201 caaaagggca ggctgcatga gcatgtaccg cttgacaccg gcggcacact gagaattgaa 1378261 ctgaatcatc gttcgtttca ccagctgcaa gagatcttta ttgaaaagac gaacgataat 1378321 cgcatattag ccgttgcgaa aaacttaagc ctcgaggaag aaaccaagga aaatggcagg 1378381 ccggttatcc ttgtcagtaa ggatgtactg gtcagggtta aagccgacgc aatcggactg 1378441 cttgctgaag atttcttgaa tgaccgggtt gtggacaatg atgaaatgta cagcggctat 1378501 aaagatttat atatcagcca gcagctgttc agctcttttt acgggaaaaa tcaaatttca 1378561 gtaaacgatg tgaaacagca tgcgttttat ccgaatcagt ttgctttaat gaaggatgag 1378621 ctaggagggt cctcctcggc agtcggaatt gcagacaaaa ccggaacggt attaaaaaga 1378681 ctcgtatttg atgatgaaca tatatgggga atcaggccga aaaatgtaca gcagacaatg 1378741 gcattagagc ttttgctgcg ggaagatatt ccgcttgtca ccctgatcgg caaagcggga 1378801 accggcaaaa cgctcttagc tttggcggca gggctattac agacagaaga cttgggaata 1378861 tataaaaagc tggtcgtcgc aaggccgatt gttcctgttg gcaaggacat cgggtatttg 1378921 ccaggcgaaa aagaggaaaa gctaaagcct tggatgcagc cgatttttga caacttagag 1378981 tttctgttta atgcgaaaaa accaggggag cttgatgcta ttttggcggg aattggctca 1379041 attcaggtag aggcgctgac ttatatcaga gggagaagca ttccagatca atttattatc 1379101 attgatgaag cgcaaaattt gaccaggcat gaggtgaaaa cgttgctgac gagagtcggt 1379161 gagggcagta aaattgtctt aatgggcgac cctgaacaaa ttgatcaccc atatttagac 1379221 agtctgaaca atggtttggc ctatgtggtt gagcggttta aaggacaacc catctcaggc 1379281 agcgtgaagc tgttaaaagg tgagagatca ggtctcgccc agcttgcagc tgatttgctg 1379341 taacacttaa atgatttcga tctcttttac atcggtaatc ggctgtttgt gatgaaccgg 1379401 gtcttcaaag taaatatgca cggggccgcc ttcttgaatc ggcttgcctg cctcactgaa 1379461 atggacaata ctgttcagag cggtttccag agaaacggcg gcctttcccg aacttgtgac 1379521 aaatacacat tgtgtcgcag agctgttcgg ctcagcattt ttcaggacag tcccaagtct 1379581 cattgcgaaa ctgccgttca tcagtttttg cttctcatat tgcttttccg tctttaatgt 1379641 aggcggcgcg attcgcccct ctctgatgac gcgttccgga tcaaggtcgg attcatcccc 1379701 ggctgattgt aaatatgtgt cttgactgtc ccctttgcgg tcaaacgaaa atttgcgatc 1379761 atcaaaaatc catacgcttg gatcaatggt aattggatat gtaacattgc cttttacttg 1379821 gataacgctc atgatatgac ccccttctct caaaattata aaagttttcg catgaattgt 1379881 cactttgtgt acaaattatg tgtattgaaa tgctgaggga acgagggtgt ttgcatggta 1379941 tgccagcata atgatgagct tgaagcctta gtgaaaaagg cgaaaaaagt aacggacaag 1380001 ggggaggtag ccagctatat tcccgccttg gcaaaagctg ataaacacga cctgtcagtg 1380061 gcgatttatt attccaataa tgtttgtctg tcagcaggtg acgtagaaaa aacatttacg 1380121 cttcaaagta tatcgaaagt cctttccctt gctttggtgt taatggaata cggcaaagat 1380181 aaggtcttca gttatgttgg acaggagccg accggtgatc cgtttaattc aattatcaag 1380241 ctcgaaacag tgaatccgag caagccgtta aaccctatga ttaatgccgg ggcattggta 1380301 gtgacaagtc tgataagggg aagaacggta aaagagagac ttgattattt gctttctttt 1380361 atcagaaggc tgacaaacaa ccaagagatt acatactgcc gggaagtggc tgaatctgaa 1380421 tacagcactt caatgattaa tcgggcgatg tgttattata tgaagcagta cggcattttt 1380481 gaagatgatg tagaggcagt aatggattta tatacgaagc aatgcgcgat tgagatgaac 1380541 agcttggatt tagcgaaaat cggatctgta ttcgcattga acggcagaca tccagagact 1380601 ggggagcagg tcatctcaaa agatgtcgct agaatttgca aaacgtttat ggtgacgtgc 1380661 ggaatgtaca atgcaagcgg ggaattcgca attaaggtcg gaattcctgc gaaaagcggc 1380721 gtatccggcg ggataatggg catttcgcct tacgatttcg ggatcggcat attcggcccc 1380781 gcattagacg aaaaagggaa cagcattgca ggtgtaaagc ttttggaaat aatgtctgag 1380841 atgtacaggc tgagtatttt ttaatttatg tcatatgctt aaatcctctt gcattttctg 1380901 ttgataccct ttatgataaa tagaagaatt aggtactcgc ctggggaacg gagggatact 1380961 tttggcttca gagatgatag ttgaccatcg gcaaaaagct tttgaactct taaaagtgga 1381021 cgctgagaag attttgaagc tgatccgagt acaaatggat aacttaacga tgcctcaatg 1381081 tcctctatat gaagaggttt tagatactca aatgttcggg ctttcgaggg aaatcgattt 1381141 tgctgtccgc ctgggattgg ttgatgaaaa agacggtaaa gaccttttat acacattgga 1381201 gcgcgaattg tctgctttgc atgacgcgtt tacagctaaa taaatgataa aactcaaact 1381261 tattaacagt ttgggttttt ttataaccgc tatttttctc tcatctcata aaagacggtc 1381321 tttttttaca cattccttcc gaatcgtata gagattcttc gtctcgtttg ataaattgta 1381381 gtaaaataaa aaagataaat acataaaaac catagataat ggaagttaga agcagggaag 1381441 aggatgttat gttaaaaaaa atgctaaaat cttatgatta ctcactgata ttcgcaatcg 1381501 ttttattatg cggattcggt ttagtgatgg tatacagctc aagcatgatt acggctgtct 1381561 cccggtatgg agtaagcagt aattttttct tcatgcggca gctgtttgct ttaattgcgg 1381621 gtggcgctct atttattctc atggcgttgt ttccttataa agcactggcc catcaaaagt 1381681 ttcagaaggg gatactgctt gtatctgttc ttgcgcttat ctcactgttt gttttcgggc 1381741 atgttgccgg aaacgcgcag agctggttta aaatcggcgg aatgagtatt cagccggggg 1381801 agtttgtgaa actggtcgtg attttatacc ttgcagccgt atatgcaaaa aaacaaagtt 1381861 atatcgacca tctgttaacg ggagtagccc ctccggtagt catgacgctt ataatttgtg 1381921 ggttaattgc catgcagcca gatttcggta cagccatgat tatagggtta attgcgacgt 1381981 gcatgatctt gtgctccggc ttcagcggaa agacgctggt gaggcttgtg atactgggcg 1382041 gaattgtttt cattttagtc agccctatta tctatttgaa tcaggacaaa attttaactg 1382101 aaggccgttt agcgcgtttt gagagtcttg aagacccatt taagtatgca aattcatcag 1382161 gtttgcaagt gatcaattct tattatgcga tcagctcagg cggcattttc ggcctggggc 1382221 tcggtgaaag tatccaaaaa tacggatatc tgcctgaatc acacactgac tttattatgg 1382281 ctgtcattgc tgaagagctc ggcatttttg gggtattgtt tgtgattttc ttattgggtt 1382341 ttgtcgtcat aaaaggtttt tatattgcca gaaaatgcga ggacccgttt ggaagtcttc 1382401 tggcgatcgg catttcaagc atgattgcca tccagtcgtt tattaacctt ggcggtgtca 1382461 gcggattaat tccgattaca ggggttacgc tgccatttat cagttacggg ggctcttctt 1382521 tggtgctgct gctggggagt atggggatat tagcgaatat cagcatgttt gtgaaatatt 1382581 cagagaataa gaaaaagaaa gagcccttgg cgccgaaggg aatgaaaaag aaacagctca 1382641 aaaaaactgt ttatctgtaa aaaacaagtg tgtacagggg aaggatattc cgctatgata 1382701 gattatattc cattcgggta agggggagaa aagtttgtct cagcaatcga tacaaaaagt 1382761 attagtagca aacaggggag aaattgcaat ccgaatattc cgggcgtgta ccgagttgaa 1382821 tattcgtaca gttgcggtct attcaaaaga agattccggt tcctaccatc ggtacaaagc 1382881 ggatgaagca tacttggtcg gtgaagggaa aaaaccgatt gatgcttacc tggatattga 1382941 aggtatcatt gatattgcga aaagaaacaa agtcgatgca attcatccgg gatacggttt 1383001 cttatctgaa aatattcatt ttgcgagacg atgtgaagaa gaaggcatcg tattcatagg 1383061 gccaaaatcc gagcatctcg atatgtttgg tgacaaggta aaagcgcgtg agcaggcaga 1383121 aaaagcggga atccccgtga ttccgggaag cgacggtcct gccgaaacgc ttgaagccgt 1383181 cgaacaattt ggacaagcta acggttatcc gatcatcatt aaagcctcgc ttggcggcgg 1383241 cggccgcggt atgcggattg tcagatctga aagtgaagtt aaagaagcat atgagcgtgc 1383301 taaatcagag gcgaaagcag cctttggcaa tgatgaagtt tatgtagaaa aattaattga 1383361 gaatccgaaa catattgagg ttcaggtcat tggagacaag cagggcaatg tcgtccatct 1383421 ttttgagagg gattgctccg ttcaaagacg ccatcaaaaa gtcattgaag tggcgccgag 1383481 tgtctcgctg tcacctgaat taagggacca aatttgtgag gctgcagttg cgcttgccaa 1383541 aaatgtaaac tatataaatg cggggacggt cgaattcctt gttgcaaaca acgagttcta 1383601 ctttattgaa gtaaatcctc gcgtacaagt tgaacacacg ataacagaaa tgattactgg 1383661 tgtcgatatt gttcaaactc agatccttgt tgcccaaggg cacagccttc acagcaaaaa 1383721 agtaaatatt cctgagcaaa aggacatttt tacaatcggc tatgccattc agtcacgggt 1383781 tacgactgag gatccgcaaa atgatttcat gcctgataca ggaaaaatca tggcttaccg 1383841 ctcaggcggc ggttttggtg tccgtcttga taccggaaac agcttccagg gcgccgtgat 1383901 cacaccatac tatgattcac ttctcgttaa gctttcaact tgggctttaa cgtttgaaca 1383961 ggcagctgcc aaaatggtgc gaaaccttca ggagtttaga atcagaggca taaaaacgaa 1384021 cattccgttc cttgagaacg ttgcaaagca tgagaagttc ctgacagggc aatatgatac 1384081 atctttcatt gatacaacgc ctgaattatt taatttccct aaacaaaaag accgcggaac 1384141 gaaaatgctc acttacatcg gcaatgtgac agtgaacggc ttccctggaa tcgggaaaaa 1384201 agaaaaaccg gcgtttgaca aaccgttagg cgtaaaggta gacgttgatc agcagcctgc 1384261 cagaggaaca aagcaaattc tcgatgaaaa aggtgcagaa gggcttgcaa attgggttaa 1384321 ggagcagaaa tctgtccttt taactgatac gacattcagg gatgcccacc aatcgttatt 1384381 ggcaactaga atcagatcgc atgatttgaa aaaaatcgca aatccgacgg ctgcgttatg 1384441 gcctgaacta ttcagtatgg aaatgtgggg aggcgcgacc ttcgatgtag cctaccgatt 1384501 cctgaaagaa gatccgtgga aacgtttgga agatcttcgc aaagaagtgc cgaatacctt 1384561 attccagatg ttgcttcgct catcaaatgc ggtcggctat acgaattatc cggacaatgt 1384621 gattaaagaa tttgtgaagc aatcagctca atccggtatt gatgtgtttc gtattttcga 1384681 cagcttaaac tgggtaaaag ggatgacgtt agccattgat gctgttaggg ataccggcaa 1384741 agtggcagaa gctgcgattt gttatacggg agatatcctt gacaagaacc ggacgaagta 1384801 cgaccttgca tattatacat cgatggcgaa ggagcttgag gcggccggag cccatattct 1384861 cgggattaaa gatatggcag ggctgttaaa accgcaggct gcatatgagc tcgtttctgc 1384921 gttgaaagaa acgatcgaca ttccggttca ccttcatacg catgatacga gcggaaacgg 1384981 tatttatatg tatgcgaaag ctgttgaagc cggcgttgat atcatagacg tggcggtcag 1385041 ctcaatggcg ggattaacgt cacagcctag cgcgagcgga ttttatcatg cgatggaagg 1385101 caacgaccgc cgtccggaaa tgaatgtcca aggcgttgaa ttgctgtccc aatattggga 1385161 gtcggtgcgt aaatattata gtgaatttga aagcggaatg aagtctccgc atactgaaat 1385221 ttatgaacac gaaatgccag ggggccaata cagcaacctg cagcagcaag ccaagggagt 1385281 aggccttggc gaccgctgga acgaagtcaa ggaaatgtac agacgcgtga acgatatgtt 1385341 cggtgacatc gtcaaggtaa cgccttcctc aaaagtagtc ggagatatgg cactctacat 1385401 ggtgcaaaac aatctgactg aaaaagacgt ttacgaaaaa ggtgaatctt tagatttccc 1385461 tgattctgtc gtggagcttt ttaaaggaaa tatcggccag cctcatggcg gattcccaga 1385521 aaaactgcaa aagctgatct taaaagggca ggagccgatt acagtcagac cgggcgaact 1385581 gcttgagccg gtgtcatttg aagcgatcaa acaggaattt aaagagcagc ataacttgga 1385641 aatttcagat caggatgctg tggcatatgc cctttatcct aaagtcttca ctgattatgt 1385701 gaaaacgaca gaaagctatg gagacatctc ggtattagat acaccgacat tcttctacgg 1385761 tatgacatta ggtgaagaga tagaagttga aattgagcgc ggcaaaacgc tgatcgttaa 1385821 gctgatttca atcggtgagc ctcagcctga tgccacccgc gtcgtttatt tcgaactcaa 1385881 cgggcagccg cgtgaagtag tcattaaaga tgaaagcatt aagtcttccg ttcaggaaag 1385941 gctgaaagca gaccggacaa atccaagcca catcgcagct tccatgcctg gaacagttat 1386001 taaggtattg gctgaagcag gcacaaaagt caataaaggt gatcatttga tgattaatga 1386061 agcgatgaaa atggaaacaa cggttcaggc gcctttctca ggaacaatca agcaggttca 1386121 tgtgaaaaat ggtgagccga tccaaacggg agatctgctc cttgaaattg aaaaagcata 1386181 aaaaacaaag agtgtatatc aatgatatac actcttgttt tttatataga aaatgtggag 1386241 tgaaacagat ggttagaaga gatataaggg gacttcagag attatagagt actgtcacaa 1386301 gcccaaaata aaaagaggct tatacagcca atattttaga tgctttgtag tatgccgtgc 1386361 atatttcttt aagcactatc tgatttaaaa ggctttaata cttatgttcg cgagctatag 1386421 atccatatga aatttctata atcacgatga gaaaggggac agaccgaagt gagccgctca 1386481 ctgatcatca agttcggcga aggctggcga ttgaaacgca taaagcgcca aaaaacaaga 1386541 cataaaaaag accaaagccg cctaaggctt tggtcttgag tccttatgat tgcctggatt 1386601 cataacggaa acgagcaatc aataataaga agtagcatag aacgccaaac agacaggcaa 1386661 taaagaacga gtgggcaagt gcaaagccca gagccagttc agagtatacg atcataatac 1386721 cggacagtgc ctgtaatgta atgaaaataa gacatgagat ccatccccaa aagatctgtt 1386781 tttgatcttt ataggaagta atagcatgaa cagcggcaac aataatccat acaaataaaa 1386841 gtaaggctgc tgctctgtgg cccatttgca cccattcatg gaattgggtc ggaagtccat 1386901 tgttcagcgg gctgcacagc ggcacattag gacatgccag acttgattca gtgtgtctta 1386961 catatgcgcc tgtatacaca acgatatagg aatatattaa aattcctatc atgtgaaatt 1387021 gcatcttttt gccgatttga agcggcttaa ccagtgttct gactgattta tcagcttcaa 1387081 atatgagcaa tgttaaaata agcactgaag caaaagaaat taatgagatg ccgaagtgaa 1387141 gcgccataat cagcgcgttc gaaccgaata cgacagccaa tgcgccaagc aatgcctgaa 1387201 gaaataaaaa gataattgac atgatcgcga gaaacgttgt ttcacgaaaa atcggcgtga 1387261 tttttctcca tgaccaaaac gcaaggctta gcacaaggat aatagagatt ccgcttgcga 1387321 atcggtggct ccattcaata attgaagccg gattcagttc agggaaaaaa cggccgtgac 1387381 acagcggcca ctgtctgccg catccttggc cggaacctgt ttttgtaacg agggcacccc 1387441 cgattaaaac aattagcatg acaaatgtcg tcagaacacc gagagctttt aatgctttat 1387501 tcatacaata ttcaccttct taacatactg ctgcaatttt atatacgttc caagtgtaag 1387561 cgaatatgtg ttttgtggca attcccagag ccttttgttc acaaaaatat aatagaatga 1387621 cggcttctgg aaaatgtaca cttgattatt catgccgggt ctgatagaaa taaggtaaac 1387681 gcaatgccga tttggagatt gccttcatct ttggtaaaat tcataaaaag ttcacaaata 1387741 aattcctgtt tgtcgtttaa tatttaatag gatgtttttt tacaagatgt tatcttgtat 1387801 gatagagttg caggttattt tattctcctg cgttaggttt gtaagggagg tttacgttat 1387861 ggctaactcc agaatcttaa atgatacagc tatagacgga caaattgaag aaacaacggc 1387921 atggaaagat tttctgtccc ttattaaaat agggatcgtc aattctaacc tcatcacgac 1387981 tttcactgga atgtggcttg cactgcatat atccggttta agttttttag gcaatataaa 1388041 caccgttctt cttacgttaa tcgggtcttc actgattatt gcgggctcct gcgcgatcaa 1388101 taactggtat gaccgggaca ttgaccatct tatggagcgt acgaaagtaa gaccgacggt 1388161 tacgggtaaa attcagccga gtcaggcgtt atggtctgga attttgctgg ttgctttagg 1388221 attgatcatg ctgctgatga caactgtcat ggctgctgtt atcggtttta tcggagtctt 1388281 tacgtatgtt gtattgtaca caatgtggac gaaacgccgc tatacgatta acacagtagt 1388341 aggaagcgtt tccggtgcag tgccgccgct tattggatgg acggcagtgg aagggaatat 1388401 cggtgtcgta gcatgggtgt tattcatgat tttatttatt tggcagattc ctcacttctt 1388461 agcattggct attaagaaaa ctgaggatta cagagctgca aatattccga tgcttcctgt 1388521 cgtatacgga tttgaagtga caaaaagaca aattattgtg tgggttgcgt gcctgatgcc 1388581 gcttccgttt ttccttggta gcctgggtct tccgattgtc attctcggct tgctgttaaa 1388641 tatcggctgg ctgattcttg gcttaatggg attccgctcc aagaatatca tgaagtgggc 1388701 aacgcagatg ttcgtttact cgcttaacta catgacaatc tatttcgttg ccatggttgt 1388761 cttgacgctt ttctaaaaaa tagatatgat gcttgtttta tcgcttcaaa ataaacgatg 1388821 acaactagta aatgccgcct tgacctcttg tttaatcagg cggctttact tttatacata 1388881 gatggcattt tgagtaaaaa aactcataat ttaagagaag aggaaatgta agtgctttat 1388941 tggtgatagg ttggatggcg atagatttcg atccgctttc cgcctttgta ttgaccagaa 1389001 aaggggttgg gtgaaatggt aaagcattgg cgtcttattt tattattagc cttagtgccg 1389061 cttctattaa gcggatgtgg aaaacctttt ttatccacgc tcaagcctgc tggcgaggtg 1389121 gctgataaac agtatgacct gacagtgctc agcacattga ttatggtggt tgttgttgca 1389181 gtagtatctg ttatcttctt ttatgtgatt gtgagattca gaagatcacg ggtcggtgag 1389241 aacacgatac cgaaacaggt agaggggaat aaatttttag aaatcacatg gaccgtgatc 1389301 ccgattttgc tgctcattat tcttgtgatt cctgttgtat tatatacgct ggagctagcg 1389361 gacacatcac caatggataa aaaaggccgc aaagctgagg atgctcttgt agtcaatgtt 1389421 agggcaaatt tatactggtg ggagtttgag taccctgatt acggcattat cacaagccag 1389481 gagctgattg taccgacaga tcagcgtgta tattttaatt taaaagcctc tgatgtaaaa 1389541 cattccttct ggattccttc agttggagga aaacttgata cgaatacgga taatgaaaat 1389601 aagttcttcc tgacatttga ttcaaaacga agcaaagagg caggagatat gttttttggg 1389661 aagtgtgcag agctttgcgg cccttcacat gcgctgatgg attttaaggt gaagacgatg 1389721 tctgcaaaag aatttcaggg ctggacaaaa gaaatgaaga actataagtc tacagcagag 1389781 agcgatttgg ctaagcaggg tgaagaactg tttaaagaga aaaactgcct gagctgccat 1389841 gcggtagagc cgaatgataa gcgtgcagaa gccgctagaa cggcacctaa cttggcgacc 1389901 ttcggtgaaa ggacaaaagt ggcaggggtg aaagaggcca acaaagaaaa tgtgaaggct 1389961 tggctgaagg accctgacag cataaagccg gggaacaaaa tgacaggcac atatccaaag 1390021 ctctcagaca gcgaaacaaa tgcgctttat gaatacttaa aaggcttaaa agcggaaagc 1390081 aagtagggaa gaaagggaga tattggggga ggtcacatat gttgaatgcg cttacagaaa 1390141 agcggacgcg cggatctatg ctttgggatt atttgacgac ggtggaccat aaaaaaatcg 1390201 caattcttta tttagtggca gggggattct tctttcttgt cgggggaatt gaagcgatgt 1390261 ttatcagaat tcagcttgca aagccggaaa atgcgtttct cagtgctcaa gcgtacaatg 1390321 aagtaatgac tatgcacgga acgacgatga tctttctggc tgcgatgccg ctcttatttg 1390381 ccttgatgaa tgcggttgtg cctttgcaga tcggggctcg ggacgtttcg tttccatttt 1390441 taaacgcgct tggtttttgg ctcttctttt tcgggggcat tttcttaaat ctaagctggt 1390501 ttttgggcgg agcgccagat gcgggctgga catcatatgc ctcactttcg cttcattcta 1390561 aagggcacgg catagacttt ttcgtcctcg gactccaaat atcggggctc gggacgctga 1390621 tagccgggat taactttttg gccacgatta tcaacatgag ggctccgggc atgacgtata 1390681 tgaggctgcc tttgtttaca tggacgacat ttgtggcctc ggcattgatt ttgttcgcgt 1390741 ttccgccgct tacggttgga ttggctctca tgatgctgga tcggctgttc ggaaccaatt 1390801 tctttaatcc ggagcttggc ggaaatacgg tcatttggga acatttattt tggatcttcg 1390861 gccacccgga ggtttatatc ctaattttgc ctgcattcgg tattttttct gaggtcatcc 1390921 ctgtgttcgc cagaaagcgt ttgtttggct attcttcaat ggtttttgca atcgtgctca 1390981 ttggctttct gggctttatg gtttgggtgc accacatgtt cacgactggt ctcggcccga 1391041 ttgcaaatgc gatttttgcg gttgcaacaa tggctatcgc gattccgacc gggattaaga 1391101 tttttaactg gctgttgacg atttggggag gaaatgtgaa gtatacaacc gctatgctgt 1391161 atgctgtctc atttattcca tcctttgtgc tcggcggtgt gacgggagtc atgctggcag 1391221 ctgctgcggc tgattatcag tttcatgata cgtattttgt ggttgcgcac ttccactacg 1391281 tcattattgg cggcgttgta ttcggccttt tagccggtgt tcatttctgg tggccgaaaa 1391341 tgttcggtaa aattctgcat gaaacgatgg ggaaaatttc atttgtattg ttttttatcg 1391401 gctttcacct cacgtttttc attcagcatt ttgtcggctt aatggggatg ccgcgccggg 1391461 tttatacgtt tttgccagga cagggtctgg aaaccggcaa cttgatcagt acaatcgggg 1391521 cgttttttat ggcggcagct gttattcttc tgctggtcaa tgtcatatgg acatcggtaa 1391581 aaggtgaata tgtaggtgct gatccatggc atgacggacg tacgctggaa tggaccgttt 1391641 cttcaccgcc gccggagtat aactttaaac agcttccttt tgtcagagga cttgatccgc 1391701 tttggatcga gaagcaggca gggcacaaat caatgacgcc ggcggaaccg gttgatgata 1391761 ttcatatgcc aaacggctca atcctgccgc tcatcatttc cttcggcctt tttgtcgcag 1391821 cgttcgggct gctgtacaga agtgattacg cttggggcct gccggtgatc tttatcgggc 1391881 tcggcatcac atttattacg atgctgcttc gttcagtaat tgatgatcac ggctatcata 1391941 ttcataaaga ggaactgccg aacgatgata aaggggtgaa ggcataatgc aagttcaaga 1392001 aaaattcacc gcagaaacct ttccagcttc tcctgaaaaa gtaaccctgg aagggaaaaa 1392061 taaattttta ggcttttggc tttttcttgg cggagagact gttctgtttg cgtctctctt 1392121 cgccacgttt cttgcgcttc ggaattcaaa tgccggtgat ccgcctacga cggaaatgtt 1392181 cgatgtgaca cttgtattca ttgccacaat gcttctatta acgagcagtt taacgagtgt 1392241 gtacgcgatg taccacatga agaacttttc cttcggcaag atgcagcttt ggctgggaat 1392301 tacgatttta ttgggggcgg gctttttagg actggaaatc tatgagttca agcattacac 1392361 ccatgaattt ggctttacca tcacaagctc tgcccttggt tctgcgtttt acacgcttgt 1392421 cggtacacac ggcgcccacg tggcatttgg gcttatgtgg atcagcacgc ttatgatccg 1392481 caatgccaag agagggctga atctgtatac ggcgcctaag ttttacgttg ccagccttta 1392541 ttggcacttt attgatgtcg tgtgggtctt catctttacc gttgtatatt taatggggat 1392601 ggtgggataa acatggtcga taaaaaaagc agagggcata tcaatagcga ccttgaattt 1392661 aagaaaaaaa agcatgcccg ggagatgaaa tatcaagtcc tgtcttttgg tttaatgatc 1392721 ggtcttacga ttgttgcatt tctgactgtg gccacggacg gtgtcggcag ctggtttacg 1392781 attcctttca ttattttgct agctgcaatt caagtcattt ttcagctgta ttatttcatg 1392841 catatgaatc agaaagggca tgaggcgccg gcactgtttt tgtattcagg ggtgtttgtc 1392901 gcgtttatca ctgtgcttgc gtttgtgaca attatatggt ggtaatttga acagccgccg 1392961 gaggtgaaga aatgaatcag ttggagatat ttgggtttcg cgcgatgtgg agcccttatc 1393021 ttttttgtat cctgttaggc attacggcgc tttatctcta tttttacagg cgaatgtctt 1393081 caaagccgaa tcgaataact ggtaaagaga tggtgtgctt tctgtcggcg atgctgtttt 1393141 tatatgcagc cgagggaagc ccggttgatc tgctcggaca tattatgttc agtgcgcata 1393201 tggtgcagat ggccgtcctg tatttggttg tcccgccgct gttaatcgcg gggattcctg 1393261 catggctctg ggaaaaaatc attttcaggc cttcaatcaa accggttttt tcctttttta 1393321 cgacgccttt aattgctttg cttttgttta acggcatttt ttctttatat catgtaccgc 1393381 ttatatttga tactgtcaaa acagatccgt tttaccatac attaatcact tggcttatct 1393441 ttgtgcttgc gttcttcatg tggtggccgc ttgttcataa ggttgagcgt ctacggcagc 1393501 tcagcggctt gatgaagctg ggttatatta tggcggacgg tatgctgctc acacctgctt 1393561 gcgccttgat catgttcagc ggtgcaccgt tatacgccac ctatacagat ccggctttat 1393621 gggctgaggc aatgaggctt tgcgtgccag cggatatgat ggggcaggtc ccattaacag 1393681 ggccagagat gttgaataca ctgcctttgt tagaggatca gcagctcgga gcagtcatga 1393741 tgaaaatcat tcaggaaatt gtgtacggta cttttttggc cgttattttt ttccaatggg 1393801 tgaagaaaga aagggaaaag gacgggcagg aggagccgcc gtatattcag cagacgatat 1393861 cataaaaggt acagcgaaat atgctgtacc ttttcgttac atttgaactg tttttaacat 1393921 gttggctatg tcctgaatca gtgccttgct ttttgtcaca acctgtacgg gaaactcttc 1393981 cgtttctcca tattctactc catgagggta gtaatgcttt cctaggagag gggacattaa 1394041 ttgaatcacg gcgcgcccgc ttccgacatc gccttctgcc gcaatacctt gtatccgcag 1394101 gtaaaacgta ccctcaatcg tcgaaaactt cttgtcatag gtgactctct cgtaatccca 1394161 ttgacccgct ctgataagac ctttgctttc cattaagtcg tctagccagc tgagctcagc 1394221 cttaacccct tcaagtccgc tttcagtaaa cttcaacact gacccctcct tataaaaatt 1394281 acctttcctg acaatcatag tatgaaagcg ttaaactttc aatgaatctt cttcttttga 1394341 aagtatgcaa aaattaaatt ttgacgacaa tagcactaga ctaaaggagg ttaaacggat 1394401 gacaaaaata aaagatctga tgacagccga cttgcaatat tgcacggtat tagataatgt 1394461 atatgaagct gcagtaaaga tgaaggacgc aaatgtagga gcgataccgg tagttgatga 1394521 ggacggggaa acattggtcg gcatcgtaac cgaccgcgat ctcgtattaa gaggaatcgc 1394581 catcaaaaaa ccgaactcgc aaaaaatcac tgacgcgatg actgaaaaac ctgtcagtgt 1394641 ggaggaagat gcttcagtcg atgaggttct tcatttgatg gcatcgcatc agctcagaag 1394701 gataccagtt acaaaaaata aaaaactgac tggaattgtc acgcttggtg atctttcttt 1394761 atctgagcaa acgaatgaac gtgccggcag cgccttatcg gatatttccg aaggggataa 1394821 tagagaagaa ggcttttttc attaacacat aaatctttga catgttaaat aggctgtatt 1394881 gtaatgggat gtaaacaaga gattgtgaat cgccacgggg gtgatagatt gaaaaatata 1394941 ttgagagcaa tggttatcct tttgattatc tgcggaacct atgttctgtt tattcaatat 1395001 ggatctgttc ctgaaaagaa atcaaatgac agcgagcctc aggtgtcgaa tgaggaagcg 1395061 caaagcggca aacgaataca tatgccgact tcagggttat tgtccttcat gggcaagcac 1395121 gccgatgaag taacgaaaaa gcttggggaa cctgaacgta ttgacccttc ggcttatgat 1395181 tacgattggt gggtatacaa tcaaggtaag gatcaatata tccaaatcgg ggtattaaac 1395241 aataaagtgg tcacattatt cgcgtcgggt aatgatatta acgccaagcc tttcaaaatt 1395301 ggagaatcaa ctggcgaagt attcaagacc acccaggtgg caccatttgt gaatgtagag 1395361 tataaaggaa attcctatcg gtttgaattt tctgaagaag atatcaatac aagaccgact 1395421 gtaaaggtag gaaagatgta tgtccagctg tatatggaca aatttgaggg gaagctatcc 1395481 agcatcaggg cgtttgatgc gcagaccttt gtaaagcaaa gaccttatga ggtagtgtac 1395541 cgcggggaat taattaaacc gaaagccgtt tcagatgaga aatggaaaaa gatccaaaca 1395601 acgagcgaaa agcaaatcct tgatttgacg aatgtcatac gcgttaaaca tggacttgcg 1395661 aagcttgagt gggatcagcc aacggcggaa gtggcatttg ggcatagtga ggatatgaag 1395721 gaaaataatt atttctccca tgtctctaaa aaatacggct cgctgaaaga ccgcttagaa 1395781 gaagggcatg ttgattttca gcaagcggga gaaaatatcg catacaatta tgtggacggt 1395841 ccggctgctg tagaaggctg gctgaatagc gaaggccatc gaaaagcgct tctgaattca 1395901 gattatacgc atcttggtgt cggagtagac cggaaatatt acacccaaaa ctttattaag 1395961 cgatggtaat gaaagccgcg gacgaatggt tcccggcttt ttctatttcc atacaagctg 1396021 gtctgaatga atgtgctgat agcttacaga taaggccgtt tcccatccct tcagtcaggc 1396081 tttttcacca gtgtataggg atatcgctaa aaattcattt gggaatgaat ataggcgaac 1396141 acaatgcccg acaaaacgat acattgtagt aggtaacgat tttcggaggg ggtgaggatt 1396201 gtggcgaatc aacatgccaa tcattcaatc aatgacttta aacaattcgt caaaaagcat 1396261 cccaagctga taaaagaagt gcgcaaagaa caaagaagct ggcaggacgt atatgaaaat 1396321 tgggtcctct tcggggagag cgacccgatt tgggatccat atcgggaacc ggaagaagct 1396381 tctgaagctg tgcctgaaac accgcaaaaa aatgattttg tctcgaaaat ggtgacagcg 1396441 gtgaaaaaga tggatgtcaa tcaaatgaac gaacaaatca ataaaatgag ccagtcgatc 1396501 tcatcgttgc aaagccttct taatacattt tccggaagcg gacagaagca ttctcagcca 1396561 ggctctggac agcatccttt ttcttttcga aaggattaaa aaaggggagc tcatatgcgc 1396621 aaagaggttc aggaatatat tttagcaaac gaagaacgga aacgattcat cagagaacag 1396681 ccgatatggt accgcaggct ttcaagaaaa ccggatgatc tgtcctcctt tcagcttgaa 1396741 atgatgaatt tttatgaaaa aaccattccg catcgggtga atcagtttac gaacgggatt 1396801 caaatggcgc aaatgatgat gcaaatgttt caagcgatgc ggacaaaaga ttaaaaggcc 1396861 ccgaagaagg gtcttttttc atgcggtcat aaggttttgt tggcggctgc ggttaagcat 1396921 tttccaattg gctggtttca tggtaaacta acaactggag gtgcatgtta tgtatgcgac 1396981 gatggaatcc gtgcggcttc aaagtgaagc tcagcagctt gccgagatga ttctgcagtc 1397041 ggagacggct gagaactacc gcaattgtta caagcgtctc caggaagatg aagaggcagg 1397101 tcggattatt cgttctttta tcaaaataaa agagcagtat gaggatgtac agcgttttgg 1397161 caaatatcat cctgactata gagaaatatc ccggaaaatg agggagatca aacgtgagct 1397221 ggacctgaac gataaggtgg ctgacttcaa gagagctgaa aatgagctcc agtccattct 1397281 tgatgaggtc agcgttgaga ttgggacagc tgtttcggag catgtgaaag ttccgactgg 1397341 gaacccttat tttgacggtt tgtcttcatg cggaggcggc tgcggttcag gcggaagctg 1397401 cggatgtaaa gtgtcctgac gagactggcc gtctcgtctt ttacatataa gagaaaacag 1397461 gcaggtgatt gtattggaga ataggcgcca gggcatggtt gtgtatctgc actccctaaa 1397521 gcagagcaaa atgctgagga agttcgggaa tgtgcactat gtatcaaaac gattaaaata 1397581 tgtcgtactg tactgtgata tggaccaaat tgaaaaaaca atggacaaga ttgcgtctta 1397641 ctcatttgtg aaaaaagtgg agccttctta taaaccgttt ttaaaattgg aattcgagtc 1397701 aaagcttgat aaggcaaaag aatacgatta taaaatcggc atatagctat aaaaaaatcc 1397761 ccgcaggcat ctgcggggtc cttctattcc ttaatatgtt aaggagaagg caaagggaga 1397821 ggagaaaccg gaggaagaac ttatggggaa acgtaagtct tctccgcggt tggcaacaac 1397881 atcctctaga tgctgttgct tatagtatgg acaaggatca tgctgcctat acacctgttt 1397941 atcaagatta gcgttcattg tttggaagaa tgctttatgt taagatagga ttgatttttt 1398001 tctatgtaca tagcggcgtc cggccgaata aagaaacaaa atagctttta gaaaaagtgg 1398061 tgtggaacat gagagtaatt tctggatcaa aaaaaggccg ttcactaaag gctgtagccg 1398121 gaacatcaac aagaccgaca accgacaaag tgaaggaatc cattttcaat atgatcggcc 1398181 cttattttga cgggggcagg ggacttgact tattcgcagg gagcggaggt cttggaatcg 1398241 aagcgctttc acgcgggttt gagcattgta tattcgttga ccgtgatttt aaagcgattc 1398301 aaacggtaaa atctaatttg aaaacgctgg agcttacaaa acatgcacag gtataccgca 1398361 atgatgcgga acgtgctttg cacgctgctg ctaaaagaga aaccggcttt cgcggaattt 1398421 ttctcgatcc gccgtataag gaacaaaagc tgaaagcact tttaactttg attgacgaat 1398481 atcaaatgct ggaagaagac ggctttatcg tcgctgagca tgacagagag gtcgagcttc 1398541 ccgaaaccgt aggagatctt gtgatgacaa gaaaagaaac ctatgggtta acaggtgtag 1398601 cgatttataa aaagaggggg tagtgaggtg gcgagtatag ctgtctgtcc cggcagtttt 1398661 gatcctgtga cctacgggca tctggacatc atcaaacgcg gggcgcatat ttttgaacaa 1398721 gtgtatgtat gtgtgctgaa taattcttca aaaaagcctt tgttcagtgt ggaagaacgg 1398781 tgtgagcttc tgagagaagt cacaaaagac attccgaaca taacagttga aacatcgcaa 1398841 ggcctgttaa ttgattatgc aaaaagaaaa aatgcgaaag cgattttaag aggcttgaga 1398901 gctgtatctg attttgaata cgagatgcag gggacatcag taaaccgggt gcttgatgaa 1398961 tctattgaga cgttttttat gatgacaaac aatcaatatt cgtttctaag ttcaagcatc 1399021 gtaaaagaag tggcaagata caacggctcg gtatcagagt ttgtaccgcc ggaagtagag 1399081 ttggcgcttc agcaaaaatt cagacaagga tgagggtttt gactcatcct ttttttgttc 1399141 cgtttgtcag tctgtaagaa aaaatgataa tgtacgtaaa cagcgcgcat agtgtgacag 1399201 caggtccgat ctgcacaagc agattccagc cgtttataaa ggcagttgac atgtcactgc 1399261 tgttaagaga tttaaataca tactgatacg gatcatgcca tgctgtgtaa agaggtttcc 1399321 ataaaagcat gacgaagaca gcggcataaa cgccctgcag caaacgtgcg ataaagaatg 1399381 gtttaaatct aatgtcggtt tccgataaaa tacctgccac ctgagcttgt acggaaaagc 1399441 cgctaaaccc aagaataaag ctgacgataa tggctttttg cagaagagaa acatctgtct 1399501 cgctgacaag cttgctgcct aatgtaattt caaacatccc tgataaaagc ggaatgtcca 1399561 attgagtcgg aagctgaaac aaagtcagtg ctccttttgt gaaaacagac aaaacatcag 1399621 tcagctggac cactgacaac agccgattga agacagaaaa taaaataata aagccgccta 1399681 ccataagaag cgtttgaaca gaagacgtca cggcgtcgcc taaaatttta cctaagggcc 1399741 gtttttctgc aagtctggcg gtatgaagag cgtgtaaagc atctttgact gaagggaaag 1399801 gtatcgtttt ctttcttctg agatgctgct cttccttgcg gccataggag cgcattgtta 1399861 aaccgacggc aagattcccc aaatagtgtg cagaagctaa taaaatgcct agtgatgcgt 1399921 tttgaaagaa accgacggca acagcgccga aaataaagag cgggtttgaa gaattggtaa 1399981 acgacgcgag ccgttctgcc tctactcttg aaatctgatt ttcctgccgc agacgggcag 1400041 tgagttttgc gcccgctggg tttcctgatg ccattcccat agcaagaacg aagccgccga 1400101 cacccggcac gcgaaagatc ggccgcataa aaggctcaag caaaacaccg acaaaccgca 1400161 caatgccaaa gccgattaag agttcggaca gaataaaaaa tggcagcaat gacggaaaca 1400221 caacctccca ccacatagac agcccggttt tagaggcttc gaatgaggcc tgtggatgtg 1400281 agatgacagt cgctgttaaa aaaagaaaaa acgaggcaat caaaagtgta ttaatcttcg 1400341 acaagttcat tcttacctcc ccgatgctaa aaatgcccaa tgacatgtat atcatgataa 1400401 aataatgtat gatgtaaaac ggccaagcag tacctgtcct cttgattctt tgtactaata 1400461 tacgagcata ggggttcagt ttagaccata gaattcggta tacagggaat tcaggcagga 1400521 ggttaacgct ttggccaaac ctaaaatcgg gttagcgtta ggatcgggag gggccagagg 1400581 gcttgctcat ctcggtgtgc tttccagttt acataagcac caaattgaag tggatatgat 1400641 tgcaggaagc agcatgggcg ctttggtggg cagtttttac gccgccggac atgacgtggc 1400701 aacgatgaaa aaagtagcca aagcctttaa acgaaggctt tatgctgatt atacggtgcc 1400761 gaaactcggt tttttaaaag gtgaccgcgt cagacagctt gtgcatgctt atacattcgg 1400821 aaaaccgatt gaagagctcc aaatcccgct gggcattgtt gcgtgtgatc tacagacggg 1400881 agaaaagatt gtgttccgaa aaggatcagt gtcagatgca gtgagggcca gcatcagcat 1400941 cccgggtatc tttattccgc agcggctgga cggacgcctt cttgtagacg gcgcggtcgt 1401001 cgatcgaatt ccggtttctg ttgtgaaaga catgggagct gatattatca tcgcttcgga 1401061 tgtttccagg gttcgaaaaa ctgaaacagc agtgcatatt tttgatgtga ttatgcaaag 1401121 tatggatata ctgcaaaatg aattagtgcg gcatcaaaca attgccgcag atatcatgat 1401181 tcgcccttcc cttgaaacat acagctcaag ctcgtttgcc aatattgaag aaatgatatc 1401241 ggcaggcgaa gaggcgacaa accgaatgat cagcaagata agaaaagaaa tagagaattg 1401301 ggagggctca taatttgcta cgtaaaaaac attttagctg gatgctcgtc atcctcatac 1401361 tgatcgccgt tttatcattt ataaaacttc catactatat tacaaaaccg ggagaagcga 1401421 cagagcttgc ttcattgata aaagtggagg gaggctaccc ggaaaaagga agtctgtcct 1401481 taatgactgt taaagtggga ccggctaatc catttacata tgtgtgggca aagatgcacc 1401541 cttattatga aattgttcct gatgagagca ttaaggagga aggcgaatca gataaggagt 1401601 atatgaaaag acagctccaa atgatgaaaa gctcgcaaga aaatgcggtt atagccgcct 1401661 atcaaaaggc aggaaaaaaa gtcagctatt cctttaacgg catatacgca agctcagttg 1401721 tagaaaacat gccggcaaaa gggaaaatag aagtcggtga taaaatcatc agcgcagacg 1401781 gcaaaaacta tcagtctgct gaaaagctga ttgattatat cagcagcaaa aaagcgggag 1401841 ataaagtcac gttaaagatc gaaagagaag aaaaagaaaa gcgtgtcacc cttacgttaa 1401901 aacaatttcc tgatgagccg gatcgggcag gaatcggagt ttcgctttat acagacagaa 1401961 acgtgaaggt agagcctgat attgattttg aaatcgaaaa tattggcggc ccgtcagcag 1402021 ggttaatgat gtcccttgaa atctataatc agctgacaaa accagacgaa acaaaaggct 1402081 acgatattgc gggaacaggt acgattgatg ttgacggaaa agtaggcccg atcggcggca 1402141 ttgatcaaaa agtcgtcgcc gcagacaaag ccggaaaaga cattttcttc gcgccaaatc 1402201 aaaacggcgc cagcaattcc gattataaga acgcagtaaa aacagcaaaa gatattgatt 1402261 caaatatgaa gattgtgcct gttgatacca tgcaggatgc gattgattat ttgaataagc 1402321 tgaaagcgaa aagcacctga ttctcaggtg ctttttctat acatttaaaa agtgttgttc 1402381 atcttcgtca tatcgaatcg gtgcatgtcc gtattcctgt aggtcaaact cagttctcag 1402441 cggctcttct atcggcaggc tgtaaatcct gcttgctttt acgtccagat cgagagctgg 1402501 atgggagaaa gaggacagtt tgctgacaag cggaacagac agtgcttttt tcttttcgga 1402561 taaataagcc tgtccttttt tcgtcatgcc gagaagcctg atatacggcg ccttatcgtt 1402621 gtcaagcagc ttttgcatat cctgtttttt tgttctggtt aaaatgtgtg tattcatccg 1402681 ctggagcctt gtccacgtat agcgttttgt tttcagcagt tccataaatt cctgatagga 1402741 gctggatttt ctgatcgaac gaataattct gtgctctaaa ccttcctcca cctcgtatac 1402801 ttgctgtaat tcccgtgccg ttacagttga aaggctgtat tttaagtaag aaaagtagct 1402861 ttcaggtgta tgccacaatc cgaaagattt gcggtaagct gctaattcac gtgcagatgc 1402921 agcagggaga aaacgaaggc aggcttcgag attctggcca atcatcgctt ttctaatgct 1402981 tgtggcactt gctatatggt tttcgccttc agggagatcg gcatcatgat agtccgaaga 1403041 gattcgtgcc gtagtataag gtttcatagg atatcccccg gttagaatcg aggtcacata 1403101 ctggtatccc aaaatgttat ttggttttga caagtcaagt gcactttcag tatgcaaaat 1403161 ggagctgaag gcgatagccg ccgctgctgg gtaactggcc ccctttttaa gttcttcttt 1403221 aattcggtca ttcaatatat gtttatgctc atcaataagc tgtgctgttt ctaaaaaagg 1403281 cttgatatcc ccattttcac tcccgaaaaa cagcgcctca cattcaagtt cgttcaggat 1403341 ggaaacactg ccgcgtgcaa aaatgtctgc tttttgcacg gcataaagat aaggcagctc 1403401 aatgacaaga tcaactccgc tttgcagcgc catttttgtt cgggcccatt ttgatacaac 1403461 agcgggttcc ccgcgctgta aaaaatgtcc gctcatgacc gcgacagccg tgtcacatcc 1403521 ggtttgcagc tttgctgttt gggcatgata aaggtgaccg ttatgaaagg gattatattc 1403581 aaccaccaat ccgacagctt tcatattttt tccgcctttc ttgctatgtt taaaaacgta 1403641 tggtacattt gcaaatgaaa actcttacgc cttatttttg ttttaagtgt atgcatagca 1403701 tattccgctg tcaacgatac ttcaatggca gcattatgct gtaaagaaaa aatattgaca 1403761 aaaacaatct taaaagctat aatcatgttt gttgctttcc tgaggtgata caaatgaaat 1403821 ggacgattta tcagctgcat caaatgccaa aacaaagttt tgagtttgat gaaacagttg 1403881 agttaaatga gctgacaaag ctgaattctg acattcgccg catttctccc gttcgggtga 1403941 agggcagagc ggatatcaaa tccaaacagg tttcgtttga ttttacaatt tcaggcgaaa 1404001 tgcttttgcc atgctcaaga acactcgttg atgttccgta tccatttgaa atttcaacaa 1404061 aagaactgtt tatatttcat cacacggatg atatagaaga tgatgacgtt cacattgttg 1404121 aggacgatac tatcgacata actccgatcg tgaaagaaga aattctttta gaaatcccta 1404181 tgcaaatctt ttgtgaatct gaacaagaaa aaggagctgc tcctcaagaa ggaaaggatt 1404241 ggcaagtcat ttcggaagaa gacaagaaga atcaagttga tccgagactt gcagcccttg 1404301 aaaagctctt aaaacaagat gatgaatctt aactctttaa ggaggtggga ataatggctg 1404361 taccttttag aagaacttct aaaatgaaga aaagattgcg ccgtacacat ttcaaactta 1404421 atgtacctgg tatgacagaa tgtccgtcat gcggagagat gaagttgtct caccgtgtat 1404481 gcaaagcatg cggatcatac aacggcaaag acataaatgt aaaaagtaac taatgagaaa 1404541 agcgcagggt gaaagccctg cgctttttct ttttctcttc ctgtcagctt gcggaaaatt 1404601 tgtgagtgca aatagtctat ctaatctatt accggcatat gtatgagata aataagctga 1404661 catggaggga gattgaattt gaccattaca agacaagatg cttggactca ggatgaggat 1404721 ttgctgctgg cagaagtggt gcttcgtcat attcgagagg gaggaacaca gctttcagcc 1404781 tttgaggagg ttggaagggc gctgaccaga accgcggcag cctgtggttt caggtggaac 1404841 tcgtatgtga gaaaacaata ccagtcaggt atagagcttg caaaaaagca aaggaaagaa 1404901 ctgagaaagc aaatcggcgt tcattcggtc aatatgccga attccatgaa gcagactgcc 1404961 tcggcatcgt cagaaggaaa acgagatttg tccattcagg atgtcattca atttctcgaa 1405021 caattcaaag aaacaccgtc tgcacaagaa tttcagcttg aaagggaaaa attgaaggag 1405081 caaatccaat cgctgcaaaa agagcttgag gatttgcgga gtgaaaatca gacattgcgg 1405141 aatcagctag agatgacaga agaggattac aaggcactga tcgatatcat ggatcgggcc 1405201 agaaaaatgg ttgtttcgaa ggaagacgga agaatgaaaa aagcggctca agaaacgtaa 1405261 agaaacgcct gaaatgaacc ggccctatag taagaatagg ccggttgttt tgatttctat 1405321 gcagactctc ccggtgtcat ttcgcgatcc atatcaggat gccagatgag cgggttttcc 1405381 cctttgtccc gcgccatatc atacttaaca gttttaaagt tcattttgtt ccaaaattcc 1405441 gctgatttca ttctcggatt tgtccggatc ggcattttga atgattttgc aaattcaacc 1405501 aaggctctcc cgtatcccct gttctggtag cccggaagaa cctcaagctt ccacagctcc 1405561 aaataatcct ggcggttgtc aaaataggga ttcgatttgc cgttaacttg atacagactc 1405621 attcgtgcta caagtttatc gccaaaataa atcccgtaaa aaggcgaggt gctgtcattt 1405681 tcaataatat tatcctgaag ttcttcaagc attgaaagct cctgaatgcc gtattctttg 1405741 aatttcttga attcttccag cgttttatag ttgataagca gacgttctac ctttgtcaaa 1405801 caaatctccc cctttgttgt ttctacatat attgtaaacg ctttatttaa aaaatccaaa 1405861 tatttaaact ttaattttaa gcacatggga tctttgagaa gtaatttctt cttacttctg 1405921 ctatgataat acgtaaatgc taaattgggt gtgacatcat gaaaattgga attatcggcg 1405981 gaggctccgt tggtctttta tgcgcctatt atttgtcact ttatcacgac gtgactgttg 1406041 tgacgaggcg gcaagaacag gctgcggcca ttcagtctga aggaatccgg ctttataaag 1406101 gcggggagga attcagggct gattgcagtg cggacacgag tatcaattcg gactttgacc 1406161 tgcttgtcgt gacagtgaag cagcatcagc ttcaatctgt tttttcgtcg cttgaacgaa 1406221 tcgggaagac gaatatatta tttttgcaaa acggcatggg gcatatccac gacctaaaag 1406281 actggcacgt tggccattcc atttatgttg gaatcgttga gcacggagct gtaagaaaat 1406341 cggatacagc tgttgatcat acaggcctag gtgcgataaa atggagcgcg ttcgacgatg 1406401 ctgaaccaga ccggctgaac atcttgtttc agcataacca ttcggatttt ccgatttatt 1406461 atgagacgga ttggtaccgt ctgctgacgg gcaagctgat tgtaaatgcg tgtattaatc 1406521 ctttaactgc gttattgcaa gtgaaaaatg gagaactgct gacaacgcca gcttatctgg 1406581 cttttatgaa gctggtattt caggaggcat gccgcatttt aaaacttgaa aatgaagaaa 1406641 aggcttggga gcgggttcag gccgtttgtg ggcaaacgaa agagaatcgt tcatcaatgc 1406701 tggttgacgt cattggaggc cggcagacgg aagctgacgc cattatcgga tacttattga 1406761 aggaagcaag tcttcaaggt cttgatgccg tccacctaga gtttttatat ggcagcatca 1406821 aagcattgga gcgaaataca aacaaagtct tttgagcttt ttcggtaaca tgctatactc 1406881 atttcggatc actaactatt tattggagaa aggaagttct agaagatgca gctaactgaa 1406941 ctttccatca aaaatcagaa tgtgtttgta cagcactata tagatggcaa agaagaaatg 1407001 tcttcttttt ttgattacag tattcatcat aaggacatgt ggcgcgaaag actggaagac 1407061 ttatcttccc ggtttttcgc aagagaggaa ttggcggcgt acttaacctc ttaccataat 1407121 aaattcggtt caagtgcgat gcagtctgct attgagaagc tgaaggaccc gtcaagtgcc 1407181 gctgtagtcg gcggacagca ggcaggactt ttaacaggac cgctttacac catacataaa 1407241 atcatttcaa tcattgtttt agcaaagcaa caagaaaagg aactgcaagt gcctgtcata 1407301 ccaatcttct gggtggctgg agaagaccac gatttggatg agattaattt tgttcacaca 1407361 tctgaagaga atgggcctgt gaaaaaaaag ctgcctcagt cttattggaa gaaatcatca 1407421 gcagcgagta catcgcttga tcaggaaaag tgtgccgcgt ggatagatga tgtttttgcc 1407481 gcttttgaag aaacagacca tacgaataca cttctcgaca atgtgaaacg atgtttaagg 1407541 gaatctgtta cgtttactga cttctttgaa ctgctgatcg cggatttgtt ccaagaagag 1407601 ggcttagttt tattaaattc tggggatccg gggattaaaa agctggaaac ggccatgttc 1407661 caaaagattc ttcgagaaaa tgatgaactc gcccgggctg tatcagatca gcaggccttc 1407721 atgcgtcaag caggctacaa accgattatc gagtccggaa aagagcaggc gaatctgttt 1407781 tatgaatacg aagatgagcg ttttttaatt gaaaaagata acggccgatt tgtcatcaaa 1407841 gagcttgatc taggatggac gagggatgaa cttcatacac atatggaaga acatccagag 1407901 cgtttcagca acaatgttgt aacgagaccg ttaatgcagg aatttctcat tccgacttta 1407961 gcatttattg cagggcctgg ggaaatcaat tattggggcg agctcaaaca ggcatttgcg 1408021 gtgatgggct tcaaaatgcc tcctgtcatg ccaaggctga acattacgat acttgagcgg 1408081 catattgaga aaaaactggc tgaacggaat atctcattac aagacgcgat tgagcgcgga 1408141 acggagaatc aaagagagac atacttcgag cgccagattc cggaagagtt tacggcggtg 1408201 atggatcagg cgaaaagcca aattgaagcg attcacaaaa cggtccggca ggaggcgtta 1408261 aaggttgatc aaagcttgga acctttactt ctgaaaaatg ccgcttttat tcaggatcag 1408321 cttcaattct tagagcgcac ggtgatgaag cgaattgaag aaaaagaagg ctacgtcttg 1408381 aaggattatg aaagaattca aaatagcatt aagccgcttc ttgcgccgca agaacggatt 1408441 tggaatatca tgtattattt gaacaggtac ggtccaaaat tcttcacgac attcaagaat 1408501 ctgccatttt cttttcaaaa tcaacatcaa gttgtcaaac tttgaaataa agttttaaag 1408561 aaccctgact agttcagggt ttttttttat gggtaaacag tgtaaaatga agttgtggag 1408621 cgaagtggtg aatagtggtg agttaaggag agaaagtggg gcaagagatc atgtttatgg 1408681 gtgaatatca gcataccatc gatgcgaaag gccgcatgat cgtacccgct aaattcagag 1408741 aaggcctagg tgagcaattt gtgctgacta gaggacttga ccaatgtctc ttcggctacc 1408801 ctatgcacga atggaaacaa attgaagaaa aactaaaagc tcttcctctc acaaagaaag 1408861 atgcccgcgc gtttacccgt ttcttctttt caggggcgac tgaatgcgaa ctggataagc 1408921 aaggcagggt aaatatcgca tcatctctat tgaattacgc caaactggaa aaagaatgtg 1408981 ttgttatcgg ggtttctaat cgaattgaat tgtggagtaa agtaatttgg gaacaataca 1409041 cagaagagca agaagattca tttgctgaaa ttgctgaaaa catgattggg tttgatatat 1409101 aatgattctt cgtgtataac actctaaaaa caatttcaat tcatcctgat aaaaggtggg 1409161 accaacacaa tatgtttcaa cacaagacag tacttcttcg tgaaaccgta gacggactta 1409221 atattaaacc agacggtaca tatgtagact gcacactcgg cggagctggg catagtacat 1409281 acttattgca gcagttatcc gagaaggggc gtttaatcgc ttttgaccaa gatgatacgg 1409341 cattacagca tgctaaagaa gtgttgtccg attataaagg acagctcatt ctgattaaaa 1409401 gcaatttcag gtatttaaaa gaatatttga atgaacaagg cgttacagaa gtagacggca 1409461 ttttatttga tttaggggtg tcctctccgc agctggatac accggagcgc ggattcagtt 1409521 accatcatga cgcaccgttg gacatgagga tggaccagtc ggctacgctt tcggcgaaag 1409581 aagtcgttaa tgagtggcgc tatgaggatc tcgtccgtat tttctttaaa tacggagaag 1409641 agaagttcag taaacagatc gccagaaaaa ttgaggaggc aagaatgaag tctcctattc 1409701 aaactacggg ccaactggtc gatctaataa aagacgcgat tcccgctcca gcgagaagga 1409761 gcgggggaca tcccgctaaa cgcgtgtttc aggcaatcag aattgccgta aacgatgaac 1409821 ttagggtgtt tgaagaagct ttggagcagg caattgaggt tctgaagcca gggggcaggg 1409881 tatcggtcat taccttccac tcgctagaag acagaatttg caaaaccact tttaaagaaa 1409941 agtcgtcgct tccggaactt cctccgggac ttcctgttat accggaagag tttgaaccgg 1410001 agctgaagct catcacacga aaaccgatta cggcatctca agaagagctt gaagagaaca 1410061 accgggctcg ttctgccaag cttcggattg ctgaaaaaag aaaataacga aacgcgaacg 1410121 caaaattaaa aggaggtcat cagcctatga gcaatttagc ttaccaacca gagaaacagc 1410181 agcggcatgc gatcagtcct gagaaaaaag tgattgtcaa gaaaagggct tccattactc 1410241 tcggagaaaa agtgcttctt gtcctctttg ctgcggcggt gctcagcgta tcgcttttga 1410301 tcgtatcgaa ggcgtatgcg gcatatcaaa ccaatattga ggtgcaaaag cttgaggagc 1410361 aaatttcatc cgaaaataag caaattggtg acctcgaaaa aagcgttgct gatttaagca 1410421 aaccgcagcg cattatggac attgcgaaaa agaacggctt gaatttaaaa gataaaaaag 1410481 tgaaaaacat acaggaatga ttcaaatgcc aaaaaagaat aaatttatga atagaggagc 1410541 agcgattcta agtatttgtt tcgctctctt tttctttgtc atcctgggga gaatggcata 1410601 tattcaaata accggaaaag cgaacggcga agtgcttgcg acaaaagcga cagagcagca 1410661 tgaaaagaaa cggaccatcg aagcgagccg cggctcgatt ttagaccgaa aaggaaaagt 1410721 cattgcagag gacacagcga cgtataaact gattgcgatt ctcgataaaa aaatgaccac 1410781 tgatgtcaag catcctcagc atgttgtaaa caaagaaaaa acggcggaag cattgtctaa 1410841 agtgataaac ttggacaagg ccgacatcct tgatatctta aataaagatg caaaacaagt 1410901 cgagtttggc tcagctggcc gggatattac gtattcacaa aagcaaaaaa tcgaaaaaat 1410961 gaaactcccg ggcatttcat ttttacggga tacaaaacgc tactatccaa acggagtatt 1411021 tgcatctaat ctaatcggct atgccgaggt tgatgaagaa acaaatgaaa tttccggcgc 1411081 gatgggatta gaaaaagtgc tggataagta tttgaaggag cgggacggat atgtgacata 1411141 tgaaagcgac aaatccggct gggagctccc gaacagcaaa aataaaatta cagcgccaaa 1411201 aaatggtgac aatgtatatt taaccattga ccagaaaatt caaacctttt tggaagacag 1411261 catgacaaaa gtggcgcaaa agtataatcc gaaaaaaatc atggccgcag tcgttgatcc 1411321 gaaaacgggc aaagtccttg ccatgggaca gcgcccaagc tttgatccga acaagcgcga 1411381 tgtgacaaac tactataatg atttgatttc atatgcgtat gaacccgggt ccacgatgaa 1411441 gatctttaca ctcgctgctg cgatgcagga aaacgtgttt aatgcgaacg aaaaatataa 1411501 atcagggaca tttgaagttg gcggagcacc tgttaaggat cacaataacg gtgtaggctg 1411561 gggtccgaca acatatcatg acggcgtcct aaggtcgtcg aatgtcgctt ttgcgaaact 1411621 ggcgaaagaa aagctgggat atgaccgcct caatcaatat ttgcacaaat tcaattttta 1411681 ccagaaaaca ggtattgatt tgccaggaga agtctccagc aaaatcaact ttaaatatga 1411741 atttgataag gcgtcaactg catatggcca agcgtctgcg gtcacaccaa ttcagcagat 1411801 tcaggccgca acggcaattg caaatgacgg taaaatgatg aaaccttatg tcattgacca 1411861 tatcgttgac cctgataaag ataaaactat ttatcaaaat aagccggaat cagccggaac 1411921 tccaatttct gcaagtactg cgaaaaaggt gcgggatata ttaggagaag tcgttacatc 1411981 gaagatcgga acagggcaag cttataaaat cgaaggtttt gatgttgccg ggaaaacagg 1412041 tactgcgcaa atagccggta aaggcggata tttagacggc acagataact atatcttttc 1412101 gtttatgggt atggcgccaa aagatgatcc tgagctttta atttatgttg ctgtacagca 1412161 gccgcaacta aaagcaggac aaagcagttc agatccagta tcagaaatct tcaatccaac 1412221 aatgaaaaat agcctgcact acctaaacat cgaaccaact gaaaaatctg actcagataa 1412281 ggaagaaaca aaagcgcaga caatgcctga tttaacagat caaacggtag ctgctgctca 1412341 aaagaaagca aaagaggaga atctcacacc aattgtcatc ggcagtgatg tcgctgtaaa 1412401 agaacagtat ccgaaagcgg atgaggaagt tctcaccaat caaaaggtct tcctgaaaac 1412461 gggcggcaaa atcaaaatgc ctgatatgac aggctggtcg agaagagagg ttctgcagta 1412521 cggcgagctc gcgggaattc atattgaagt aagcggacaa ggctacgctg tcagccaaag 1412581 tgttaagaaa gacaaagaaa tcaaagacaa aaccgtaatc aaggttaagt ttaaaaatcc 1412641 tgattaaaaa gaaagccgtc gttatgcagg ctttcttttt ttatgccttc agaggagcat 1412701 cgttctacct gtccaaattc aggcataaaa tgaaacaagc ctaaataagg agtgaacggt 1412761 ctcttgcgcg tctcgaatgt aacggttaga aaacgtttat tatttgtttt gctttttggc 1412821 gtgatcgtgt ttctgatcat tgatacaagg ctggggtatg ttcagtttgt gatgggcgaa 1412881 aaactgactt cgctagcgaa agattcctgg agccggaact tgccgtttga gccggagaga 1412941 ggcgagattc tggatcggaa tggtgtgaag ctcgcaacaa ataaaagtgc gccgaccgta 1413001 ttcgtcgtgc cgcgccaagt tcagaatccg atgaaaacga gcaagcagct tgcggcggtg 1413061 ctcaatatgt cagaagaaaa agtatataaa catgtgacaa aaaaagcgtc aatcgaaaag 1413121 atcactcctg aagggagaaa aatttcaaat gagaaggcga aagaaatcaa agcgcttgat 1413181 ttaaaaggtg tgtatgttgc ggaggacagt atccgtcatt acccgttcgg cagcttttta 1413241 tctcatgtgc ttggatttgc aggaattgac aaccaagggc tccttggact tgaagcctat 1413301 tacgacgatg atttaaaagg ggaaaaaggt tctgttaagt tttatacaga tgccaagggg 1413361 aagaagatgc ctgatgaagc ggatgactat acgccgccta aggatgggct tgatatgaag 1413421 ctgacagttg attcaaaggt tcagacgata atggaaagag agcttgataa cgctgaggcc 1413481 aaatatcatc cggacggcat gattgccgta gccatgaatc cgaaaaacgg agaaattttg 1413541 gggatgtcta gcaggcctga cttcgaccct gctgattacc aatctgttga tccgtccgtc 1413601 tacaatcgaa atctgccagt atggagcacg tatgaaccgg gatctacctt taaaattatt 1413661 acacttgcag cagcccttga agagcaaaaa gtaaatttga aacgggatca attttatgat 1413721 aaagggcatg ctgaagtgga cggagcgaga ctgcggtgct ggaaaagagg cgggcacggg 1413781 ctgcagacgt atctggaagt tgtgcagaac tcctgcaacc cggggtttgt tgaattaggc 1413841 gagcgcttag gaaaggaaaa gcttttcaaa tatatcaaag actttggttt tggacaaaaa 1413901 acggggattg atctccaagg cgagggaaca ggcatcttat tcccgcttga gagagtgggc 1413961 ccggtggagc aagcaactac ggctttcgga cagggagtat ccgtcacgcc gattcagcag 1414021 gttgcagcag tatccgccgc tgtaaacgga ggaacgctct atacacctta tattgcaaag 1414081 gaatggatcg atcctgttac gaagaaaacg gtcaaaaaac aatcaccaat cgcaaagaaa 1414141 caagtcattt ctgaggaaac atccaaacaa atccgctatg ctctagaaag cgtcgtcgca 1414201 gaaggaaccg gccgcaatgc atttgtagaa ggatatcgtg tcggaggaaa aacgggaact 1414261 gcacaaaagg ttaaagatgg aaaatatctt gaaaacaacc atattgtatc atttatcggt 1414321 ttcgcgccag cagatgatcc gagtctagtc gtctacgttg cggtggataa cccgaaaggc 1414381 acgattcagt ttggcggaac ggtggcagcg cctattgtcg gaaatattat gagagacagt 1414441 ctgccggaac ttggtgtgaa gccccggaaa aatcaaatcg agaaaaaata ccaatggaac 1414501 gacacaaaaa caatagaagt tccgaatgtt gtagggatgt ctgtctcaga tcttgagtca 1414561 ctattggtga atctcaatgt ggatgcttcc gggaaaggga gcaaaatcgt taaacaatcg 1414621 ccagctgccg gaacgaaagt aaaagaaggc tcaaagatac gcgtgtattt gactgaagaa 1414681 gatgaaaagg aggcagccga ttgattcggg ctgcctattc ttttattgca gaaaaaatgc 1414741 tgatatcttt caagattagc tggatgtatc cttttattta cgctaaaata tgaactgtat 1414801 gcttaaaatc attaccacat catttgatgt gacttcaatg ataaaaagaa cgaattagaa 1414861 tgttgagagg tttgatacga tgaaacttac aaagctgctt acatacttaa caaccgaacc 1414921 ttctgtaaac gactcacaag accctgaaat aacttcaatt gagatggact ccagggaagt 1414981 aaagaaaggg agtctttttg tatgtgtaaa agggtatacg gtggatggcc acgattttgc 1415041 gcaaaaagca gtagaaaacg gtgcagcggc tattgtggca gaaagagagg tcgatgtgaa 1415101 tgttcctgtt attattgtcc ggcagtcact tcgcgcgctc agcgttttgt ctgatgcgtt 1415161 ttacggacag ccgacgaaga agcttcagct gattgggata acagggacaa acggcaaaac 1415221 atcaacgacc cacatggtcg atgagattct gaaaaaagcg ggaaaacgca caggcttgat 1415281 cggtacaatg tacatgaaaa tcggagacga aacacttcct gttaaaaaca cgactccgga 1415341 aagcgtcacg ctgcagaaaa cgtttaagaa aatgaatgac aagcacgttg acactgcaat 1415401 catggaggtt tcttcccacg ctttgtcttt aggacgcgtc catggctgtg attatgatat 1415461 tgccgtgttt acgaatttaa cacaggacca tctggactat cataaaacga tggatgagta 1415521 ccggcatgca aaaagcttgc tcttttccca acttggcggg gctttcaacc atgaacatcc 1415581 aaagcgtgcc gtcctgaatg ctgacgatga ggcgagcgct tattttgaaa aggtaacagc 1415641 tgcgcatatc tctacatacg gaattaaaaa cgatgctgat gtgatggcga agaacatcag 1415701 tatcactgca cagggcacaa gctttgatct cgtgacaaac aaaggcacga agcacatcac 1415761 gatgtctctc gtcggacaat ttaatgtgta taacgtgctg gccgctgttg cgacatgtat 1415821 tgcagcaggc ataccgtttg aaatcatcac tgaggctgtt gaagaattgc atggtgtaag 1415881 aggccgtttt gaattggtca atcagcagca ggagtttcct gtcattgtag actacgcgca 1415941 cacaccggac agccttgaaa atgtgctgga gacatgcaga gacatgacgg aaggaaagct 1416001 atttgtcgtt gtcggctgcg gaggagacag agataagacg aagcgcccga aaatggctaa 1416061 aattgctgtg gagctggctg acgagccgat tttcacgtca gataacccga gaagcgaaga 1416121 tcctcgcgcg attttaagag atatggaagc cggagtagag aacgcatact atcacagtat 1416181 tgcaaaccgc gagcaggcga tctttttcgc aattgccaat gccaaaaaag gcgacgttgt 1416241 cctcattgcc ggaaaaggac atgaaaccta tcagcagatc ggaaatgaaa ctttcgattt 1416301 tgatgatgct gaagtagcgg cgagagccat tgttgaactc aataagaata agacgaattc 1416361 ataggaaaga gatgttactg aataatggag cttgaaaaga tttttcatat ggaaaaaaat 1416421 catgaatatg ataactacgt atgtcgtttg aaagaaacag gaggagaaaa ggacaatgct 1416481 tgagcaagtc attctgttta caattttaat ggggttttta attagtgttc tgctctctcc 1416541 gattcttatt ccgtttttaa gaagattaaa attcggccag agtattagag aagaaggacc 1416601 gaaatcacat cagaaaaaat cagggacacc gacaatgggc ggggtcatga tcatactttc 1416661 tatcatagtg acaacaattg ttatgacaca gaagttttca gaaataagcc ccgaaatggt 1416721 gctgcttctg tttgttacgc taggctacgg tttgcttggc tttttagatg attacatcaa 1416781 ggttgtcatg aagcgcaatc ttggattgac atcaaagcaa aagctgatcg gacaaattat 1416841 tattgcggtt gtattttacg ccgtgtatca ttactacaat tttgcgacgg atattcgcat 1416901 tcctggaact gacttatcat ttgatcttgg ctgggcttac tttatccttg tgctctttat 1416961 gctagtcggc ggatcaaacg cagttaacct gactgacggc cttgacgggt tattatccgg 1417021 tactgcggcg attgcctttg gcgcctttgc cattctggca tggaatcagt ctcaatatga 1417081 cgtagcgatt ttctcagttg ccgttgtcgg tgcagttctg ggcttccttg tatttaatgc 1417141 tcatccggcc aaagttttta tgggagatac gggatcgctt gcattgggag gagccatcgt 1417201 taccattgcc attttaacga aattagagat cctgctggtt atcatcggcg gtgtattcgt 1417261 tatcgagaca ttatccgtta ttttgcaggt catcagcttt aaaacgacag gtaaacgaat 1417321 ctttaaaatg agtccgcttc atcaccatta tgagcttgtc ggctggtctg aatggagagt 1417381 agtcgtgacg ttttgggctg cgggactttt gcttgccgtt ttaggaattt acatcgaggt 1417441 gtggttataa gtggaaaatg atcaattttt acagaaacag cattttttaa tccttgggct 1417501 tgcgaaaagc ggatatgcgg cggcctccat tcttcatgaa aaaggcattt atgttgcagt 1417561 caatgatcaa aagccttttg aagaaaatga accggcacaa aagctttctg aaaaaggaat 1417621 cgaagttgtt tgcggagagc atccagtttc tctgttcgat cagcatcaaa tcacgattct 1417681 gatcaaaaac ccgggaattc cttatgaaaa tatcatggtt caggaagcag agaaacgagg 1417741 tattccggtt tggacggaaa ttgagctcgc ttactacctg accagcgcca agtttatcgg 1417801 gattaccgga tcgaacggta aaacgaccac gacaacgcta atttacgaaa tgctcaaggc 1417861 tgactcgcaa aaagcactga ttgccggaaa catcggcaca gtcgcaagtg aggttgccta 1417921 tcatgctgat ggagatgaat ggatcgttac cgaactgtct tcgtttcagc tgatgggaac 1417981 acacgctttc agaccggaaa tcagcctgat tttaaatgta tttgacgccc atctggatta 1418041 tcaccatacg cgcgaaaact atgaaaaagc gaaacagaaa gtgtaccttc atcagactgc 1418101 ttcagataaa gctattgtca accaggatga tgaaaccgtc gtgcgtcttg ctgaagccgg 1418161 aaaagccgaa atcgtcccat tttcagtcag caaaacgctt gaacagggcg catatgtaaa 1418221 agacagtatg attatgttta acggcgaagc cattcttcct ctggaagagg ttgtactgcc 1418281 cggtgctcat aacctggaga acattttagc agctattgca gttgtgaaaa cggcaggagc 1418341 atccaatgag gcggttaaaa aggtgctgac aagctttact ggtgtgaagc accgcctcca 1418401 atatgtcaca actgtgaatg gccgcaaatt ttataacgac agtaaagcaa caaacattct 1418461 ggcgacaagc aaggcgcttt cagcttttga taagccggtc attctgcttg cgggcggact 1418521 ggatcgcgga aatggttttg atgacttgaa accttatatg aagcatgtca aagcagtgct 1418581 tacatttggc cagacggcgc caaaactcga gaaactcggc aatgaactgg gaatacaaca 1418641 tgtcaaacgt gtcgataatg ttgaacaagc agtatctgcg gcgtttgcgc tctcaaatga 1418701 aggagatgtc atcctgctgt cacccgcgtg tgcgagctgg gatcaattca aaacatttga 1418761 agaacgcggt gacatgttta tagatgccgt gcatatgctt aagtaagggc ttgtcttgaa 1418821 gtaaatcggc agccctaatg actttaagct tggggtgtcg attgctttga ctactaaaaa 1418881 aacatcgcct gatttgttat tggtcatcat tacgttatta ttattaacaa tcggattaat 1418941 tatggtgtac agtgcgagtg cggtatgggc ggattataaa tttgacgact cattcttttt 1419001 cgcgaaacgg cagcttttgt ttgcgggaat cggcgtcatt gctatgtttt ttatcatgaa 1419061 tgttgattat tggacttgga ggacatggtc caaattgctg atggttatct gctttttcct 1419121 tctggtgctt gttttgatac cgggcgtcgg aatggtgcgg aacggttcaa gaagctggat 1419181 cggagtcgga gcattcagca tacagccttc agagtttatg aagcttgcga tgattgcatt 1419241 ccttgctaaa tttctctctg aaaaacaaaa aaacatcaca tcgttcagac gggggttcgt 1419301 ccctgcactt ggcatcgtgt tttcagcatt tttgattatc atgtgccagc ctgacctcgg 1419361 aacggggaca gttatggtcg gaacttgtat tgtcatgatt tttgtagccg gcgcacggat 1419421 cgcccatttc gtctttctcg ggctgatcgg cctcagcgga tttgtcgggc tcgtactatc 1419481 ggctccatat cggataaagc ggattacctc atacttaaat ccatgggaag acccgctcgg 1419541 aagcggattt cagatcattc aatcgcttta tgcagtgggg cccggcgggt tgttcggaat 1419601 ggggctcgga caaagcagac agaagttctt ttatctgcct gagccgcaaa cagactttat 1419661 tttcgccatc ttgtcagagg agctgggctt tatcggggga acacttattt tgctcctctt 1419721 cagcgtcctg ctgtggagag gaatcagaat tgcgcttggt gcgcctgatc tgtacggaag 1419781 ctttgtcgca gtcggcatta tttcaatgat tgccattcaa gtcatgataa atatcggcgt 1419841 agtcacgggc ctgattcctg taacaggcat cacgctcccg tttctgagct acggaggctc 1419901 ttcattgact ctaatgctga tggcagttgg tgtgctgctg aatgtaagcc gctactcgag 1419961 gtattaacga atgtatttcc aagcctcctg tctaacatga agcttggaaa caattgatgc 1420021 gataaccctg tccaacaaaa cagggttatc gttatgttat agagaaactt agactggggg 1420081 aaaaaagaaa tgcgaattgc aataagcgga ggcggtacag ggggacatat ttatcctgct 1420141 cttgctttta ttaaagaagt gcaaagacgt catcctaatg tggaattttt atatatcgga 1420201 acagaaaacg ggctggagaa aaaaattgtt gagcgggaga atataccgtt tcgttcaatt 1420261 gaaattacag gatttaaaag aaaattgtca tttgaaaatg tcaagactgt gatgcgtttt 1420321 ctgaagggcg tcaaaaagag taaatcgtat ttagcggaat ttaagcccga tgccgtaatt 1420381 ggaacgggcg gttatgtatg tgggccggtt gtctatgccg ctgcgaaaat gggaattccg 1420441 actattgtcc acgaacaaaa cagcctgccg ggcatcacga ataagtttct ttcaaaatat 1420501 gttaataaag tagcgatttg ttttgaagaa gcgaaatcac attttcctag cgagaaagtt 1420561 gtatttacgg gaaacccgag agcctctgaa gtcgtctcaa taaagacggg acgatcattg 1420621 gctgaatttg ggctttctga agacaaaaaa acggtcttaa ttttcggcgg aagccgaggc 1420681 gctgcaccga ttaaccgcgc tgtcattgac atgcaggatg tgctgaaaac aagagactat 1420741 caagtgctgt atatcaccgg tgaagttcac tatgaaaaag taatgaatga gctgaaaagc 1420801 aagggtgccg ctgataatat ggtcacaaag ccgtttcttc atcaaatgcc tgagtattta 1420861 aaggccattg atgtcattgt ggccagagcc ggtgcgacaa cgattgccga aattactgct 1420921 ctcggaatcc caagtgttct gatcccaagt ccatatgtga cagcgaatca ccaggaggtc 1420981 aatgcgaggt ctcttggcca gcatgatgcg gcgattgtac tgaaagaaac agagctcagc 1421041 ggggagaagc tgattgaagc gctagaccgg attgtactga atgagcaaac gttaaaggaa 1421101 atgagcgaac gaacaaagtc actcggtgtt cctgacgcgg ctgcccgttt atacagcgta 1421161 ctcgaggaat taaaaaaata gtagaaaagc aaatggaatg cggaggttta cgatggagaa 1421221 agtgatacag gaattaaaag aacgagaagt cggcaaggtt cttgcaaatg aaccgctcgc 1421281 gaatcataca acgatgaaaa tcggcggacc tgcggatgta ttggtcattc caagcagtgt 1421341 ggatgctgtt aaagacatca tggacgtgat taaaaaatat gatgtgaagt ggacagtcat 1421401 cggccgcgga tcaaatcttc ttgttttaga tgaaggaatt agaggcgtag tgatcaagct 1421461 gggggcgggt cttgaccatt tggagcttga aggggaacaa gtaacagtcg gaggcggtta 1421521 ttcggtggtc cgccttgcta catcattgag caaaaaaggc ctgtccggtt tggaatttgc 1421581 tgccggcatt ccaggatcag tcggcggagc ggtttatatg aatgccggcg ctcacggttc 1421641 tgatatgagc gagatcctcg tcaaagcgca tattttattt gaagacggaa cgattgagtg 1421701 gctgacaaat gagcagatgg atttcagcta caggacatct gtactgcaaa agaaacgccc 1421761 gggcgtttgc cttgaagctg ttttgcagct tgagcagaag gataaggaat caatcgttca 1421821 gcaaatgcaa agcaataaag actatagaaa aaatacacag ccgtattcaa gcccttgtgc 1421881 gggaagcata ttcagaaatc cgcttccgaa tcatgccggg aaccttgtag aaaaagcagg 1421941 cttgaaagga tatcaaatcg gcggtgcaaa gatatcggag atgcacggaa acttcatcgt 1422001 caatgcgggg ggagcatcag caaaagatgt gcttgatctc attgaccatg tgaaaaagac 1422061 aatccgtgaa aaatacgaga ttgatatgca cacagaggtt gaaatcatcg gcggaaatcg 1422121 ctgattcaag ttctgactga agctgttcat atgatatact gtaagcaaac gacaaacggc 1422181 atcatagtat gccgtttgtt ttggaataga cagactttta acagctgttt catttgaatg 1422241 aggtgaacag gcaatgaacc cgggtcaaga ccgagaaaaa atcgttaaca ttgaagagcg 1422301 gatccctaaa attaaagagc agaggaaaca aaaggcaaac cgccgtctca tttcatttat 1422361 tatgctcttt tttattatgg tgctgatcat tgtgtacctg caaacaccaa tcagtaaagt 1422421 atcaacaatc tctgttacag ggaatgaaaa tgtatcaaaa aaggaaatta tcgacctttc 1422481 cgatattaac agcggagata ctgagttttg gagtttggac aagcaaaaaa cagaaaagaa 1422541 gattcagcaa aataaattag tgaaaaaagc ggagatcagc aaatcgcttc ctaataaaat 1422601 caacattgca atcgaagaat ataaagcgat tgcttattta gaaaaagacg atgtgtacta 1422661 tgaagtgctt gaaaacggct cagttctgcc aaacgaagta acgccggatg atgccggacc 1422721 gattttagtg aattggacaa acgcgaagaa gcggtctcaa atggccaagc agctcgatgc 1422781 gttgtcaaat tcgttaaaac agtcgatttc agaaatttat tatacgcctg taaaaatgga 1422841 tgaaaaccgt attaagttgt acatgaacga cggttatgtt gttacggcat ctattaaaac 1422901 gtttgcagac cgaatgaaga cgtatccttc tatcatctca cagctaagca gcaataaaaa 1422961 aggaatcatt catttagaag ttgccaccta ttttgaagag tttgggaaaa acgataaagc 1423021 tgctaaaaag gaagatgaaa attgaggggc aaatcagcag tccttctttc cttgattatg 1423081 cttatcgcag gttttttgat ttcattttct tttcaaatga caaaagaaaa caacaaaagc 1423141 gcggctgaga cggaagagtg gaaaaaagaa tatgcgctga gagatgaact gctgaaacaa 1423201 gagaaagaaa ataagaagtt tgaaaaagaa ttatatcaaa agcaaaacaa agtccgccag 1423261 gcggaaaata agctgaagaa agagaagtcg gaatactata atgtcctcga agatacagaa 1423321 aaatacagga tgtatattgg ggaagtcggt gtgcagggag aaggcgttga ggtgacattg 1423381 gaagatgcgt catacatacc ggaaggggag aatgtgaata gttacatcgt tcacgaaagc 1423441 catatcttcc aagtagtaaa cgaactgtat atctcaggag cggcagctgt cgccgttaat 1423501 ggacagcgtt tgacgcatga ttcgtatatc aaatgcaatg gtcctgtggt aacggtagac 1423561 ggggtgcagc atcccgctcc gtttacggta tccgctattg gagatccaga tgtcctgctg 1423621 ccctcgttaa atatcgctgg aggcctaatt gatcagctgt caatggatca tatttctgtg 1423681 tcggcagaaa aagagaaaaa cgtacaaatg aaaccgattc tgaaaacgaa ggaatgactg 1423741 aaaaagcggg tgaaatagat tgaaaataaa gcgttccttc ataagcatca gtgttcttat 1423801 ggtcatcttc ggcctgatga tatctgttca gtttaattcg ttaaagcacc ccaaagtccg 1423861 ggatacaaga gatatgtggg atattaggga agagctgaca tcagagcaga agaagcagga 1423921 aaagctgctg gctgaaataa acaaatatga caaattgctg aatagctatt cgcaaacgaa 1423981 agaaatgaca aaagaaaccg cgctaaataa taccttgcaa tccttaaaaa aaacagccgg 1424041 catgaccgat ataacaggta gcggaattgt cattacgatt tccccgcttt tttctgaaag 1424101 cttaacagga gagccgatcg aaaatccgcc tccggatttg ctgaaaaagc tgataaatga 1424161 actcaactcc tacggtgcag agcatatctc gattaatgag cgaagagttg tgaatcatac 1424221 agtcatcaga gatataaacg gcactacaaa aatagacgga tacgcccttg acgattatcc 1424281 tttaacagta aaagtgcttg ccaaagatcc ggacatgtta cacagcagag tgaaggggtc 1424341 aggccttgag gatctttttg catctgaaaa tttagcatta aaagccggta aatctgaaag 1424401 caaactaaca ttaaaagcat atgacagacc actggacgta caacagctga aactgcttaa 1424461 agactgaaaa ggaggagaat tgtcatgtgg ctgcccgtgt tgggactggt gctcggaata 1424521 gcgattggac taatgacaaa cttaacgata ccgagtgaat actcaaacta tttatcgctt 1424581 gcggtgcttg ccgcacttga tacattaatc ggcggaatca gggcgcattt acaaggtaca 1424641 tatgatgaaa tggtatttgt ttccggtttc ttttttaata ttatattggc aataagttta 1424701 gcttttctgg gagtccatct tggtgtagac ttgtatttag caggtatatt cgcatttgga 1424761 gtcagattat ttcagaatat agccgttatc agaagaaatc tactaacaaa gtggactctt 1424821 tctaaaaaaa ataaaaaaaa tgtgatataa aagaggatat acataggata taacgaatat 1424881 tttcaataaa cataaaatgt gaaaagcaca taaaaatatt ctgttgttat tttttgttac 1424941 acacttgtaa agccacattc attgtattgt tgttccgcaa ataatagaat agaaatgatc 1425001 gaaatgtgag gaggtgccat agaatgaaca acaatgaact ttacgtcagt cttgacatcg 1425061 gtacgtccaa tacaaaagtg atcgtcggag aaatgacaga tgattccctt aatattatcg 1425121 gtgtgggaaa tgtaccgtct gaagggttga aaaaaggctc aatcgttgat atagatgaga 1425181 ccgttcattc tataagaaaa gcgtttgacc aagctgaaag aatggtaggt tttccgctta 1425241 gaaaagctat tgtcggcgtt aatggaaatt atatcaatat tcaagataca aacggtgttg 1425301 tagcagtttc cagtgaaaat aaagaaattc aggttgaaga tgtacgccgt gtcatggagg 1425361 cggcacaggt tgtttccgta ccgcatgaac agctgattgt tgacgtcatt cctaaacagt 1425421 ttatcgtaga tggaagagat gaaatcaccg acccgaaaaa aatgctgggt gtgcgtttag 1425481 aagtagaggg caccttgatc accggttcaa aaacaatctt acataactta ctccgctgcg 1425541 ttgaaagagc tggtattgaa ataactgata tttgccttca gccgctggca gccggttctg 1425601 ctgcattatc aaaggacgag aaaaaccttg gtgtggctct cattgatata gggggagggt 1425661 caacaaccat tgccgtattc cagaacggac atctcacttc tacccgtgtc attcctctcg 1425721 gaggcgaaaa tatcaccaaa gatatctcca tcggattgag aacgtcaaca gaagaagcag 1425781 aacgcgtgaa aaagcaactt ggacatgcct actatgacga agcctcggaa gatgaaatat 1425841 ttgaggtaac cgttataggc accaatcaaa aacaaacatt tacacagcaa gaagcagcga 1425901 atatcattga agcgagagta gaggaaattc ttgaaattgt ttcagaagag cttcgcagta 1425961 tgggaattac cgatctgccg ggaggcttcg tgctgacagg aggacaagca gctatgccgg 1426021 gtgtcatgtc tttggcacag gatgtgctgc aaaacaatgt cagagtggca agcccgaatt 1426081 atatcggtgt aagagatcct caatatatga cgggagtggg cctgatccaa ttcgcctgcc 1426141 ggaatgcaag aatccaaggc agaaaaatag gctttaagat gcctgaagaa gcgatacagg 1426201 aaatcgcagt ctcatcatct gaggaacaag agcagcatca tcaccaaaat gaggtgcagc 1426261 agcggccaaa aggaaaacaa aaaacacaag ccgaacataa taaacagagc aaaatgaaaa 1426321 aactattaag catgttttgg gaatagatag atagtcattc ggcagattag gaggatttag 1426381 catgttggag ttcgaaacaa acatagacgg cttagcatca attaaagtaa tcggagtagg 1426441 aggcggcggt aacaacgccg ttaaccgaat gattgaaaat gaagtgcaag gagtagagta 1426501 tatcgcggta aacacggacg ctcaagctct taacctgtca aaagcagaag tgaaaatgca 1426561 aatcggcgca aagctgacta gaggattggg agcaggtgcg aatccggaag tcgggaaaaa 1426621 agccgctgaa gaaagcaaag agcagattga agaagcactt aaaggtgctg acatggtatt 1426681 cgtgacagct ggtatgggcg gcggaacagg aacaggtgcc gcaccggtta tcgcacaaat 1426741 cgcgaaagac ttaggcgcat taacagtcgg cgttgtgaca agaccgttta ccttcgaagg 1426801 acgcaaaaga cagcttcagg ctgcaggcgg aatctcggca atgaaagaag cggtggatac 1426861 actgatcgtg atcccgaacg accgtatcct tgaaattgtt gataaaaaca caccgatgct 1426921 tgaagcattc cgcgaagcgg ataacgtact tcgccaaggg gttcaaggta tttctgactt 1426981 gattgctaca cctggtctta tcaaccttga ctttgctgat gtgaaaacaa tcatgtcaaa 1427041 caaaggatct gctttgatgg gtatcggtat tgctactggg gaaaatcgcg cggcagaggc 1427101 agcaaaaaaa gcaatttcca gcccgcttct tgaagcggcc attgacggtg cgcaaggcgt 1427161 cctcatgaac atcactggag gaacaaacct cagcctatat gaggttcagg aagcagcaga 1427221 cattgtcgct tcggcgtctg atcaagacgt aaacatgatt ttcggttctg ttattaatga 1427281 aaatctaaaa gatgagattg tggtgacagt gattgcaacc ggctttatcg aacaagagaa 1427341 ggacgtgacg aagcctcagc gtccaagctt aaatcaaagc atcaaaacac acaatcaaag 1427401 tgttccgaag cgtgagccaa aacgtgagga acctcagcag cagaacacag taagccgtca 1427461 tacttcacag ccggctgatg atacgcttga catcccgaca ttcttaagaa accgtaataa 1427521 acgcggctaa tgtaaaggac aaaatcgttt tcgattttgt ccttttttgt ttttctcttc 1427581 acactttcct tcttataaag tctttttccc tattgcttcc ttcgcgagct cgattatgga 1427641 tggtttacgt tttggaaaaa gtaaggtatc ctagttcgta caaagtttta tgaaaattaa 1427701 aacaattata aaaggcaata aagaggagga ccacgatgat tttgcagctt gacaatgtct 1427761 cactaaaacg gaatgggaaa tggatactga aagatattca ttggaaggtg gaagaaaagg 1427821 aaaattgggt gctttacggc ctaaatggcg ccgggaagac agcgctgtta aatatgcttt 1427881 gctcatatta ttttccaaca tcaggcgaga tgcaggtgct cggccatgaa tttggcaaaa 1427941 cagagcttgg ggaaaagctc agacgtaaaa ttggcctcgt ctcagcagct cttcagcaaa 1428001 aattgtatcc ggcagattca gcttttgaaa ttgctttgag cggagcttac gcttcgattg 1428061 ggttatatga aacgccaagt aaggaaacca gggaaaaagc gataggtttg ttagaggact 1428121 tgggagcaat tgaatatgcc gatcgccgct atgaaaccct ttctcaaggg gaaaaacaaa 1428181 gagcattgat tgctagagca ctaatggccg atccggagct gctgatactg gatgaaccag 1428241 tcacaggact ggattttatt gcccgggaaa agctgttaga tacgattaca tacattgcaa 1428301 acaaagaaaa tgcaccatct atcctttatg tgactcatca tgctgaagaa attttgcctg 1428361 tctttgataa agccctttta ttaaaacagg gagaggtttt tggatccgga gaaataaagg 1428421 aaatgcttac tgatcaaata ctttccgctt tttttgatac gccaatccat gtattatgga 1428481 atcaggatcg gccgttttta acaagagctg agccgataac gaatgcctga caaatatata 1428541 tagattcatc ctaggggtgc tttgcgaagc tgagagagac tttgtctcaa cccttttgac 1428601 ctgatctgga tcatgccagc ggagggaagc ggtgaaaagc ggagtacatc ggactccgtt 1428661 tgtttttatt aagccgtttc atcacatttg aaacggcttt tttgatttta aagaatagga 1428721 gcggatttac attggatcaa caaatatact ctttgcaaaa aaaagtggaa gaacataagg 1428781 aggagcttat tcagcttgcg aaaacgctga tttcttatca aacacctgct ccgcctgcaa 1428841 gaaatacaga gggcattcag tcttggattg cgggatattt aaatgaattg ggattctcga 1428901 tcgacaaatg ggatgtgtac cctggagatc ccaatgttgt agggaagcta aaaggaacag 1428961 attcagcaga ttattatagc ctgattatca atggccatgt agatgtggca gaggtaaaag 1429021 aggatgaaga atggaagcac gatccgtttc atcccattga aaaaaacggt ctcttaatcg 1429081 ggcgaggcgc ttccgatatg aagggcggaa tggcttgtgt gctgtttgct gtcaaattaa 1429141 ttcgtgaagc aagcattgaa cttccaggtg atctgattct gcaatcggtt attggggagg 1429201 aagttggaga ggccggcaca cttgaatgct gcaagagggg ctaccacgct gattttgcaa 1429261 ttgtcgcgga tacgagcgat atgcatattc aaggccaagg cggtgtcatt acaggctgga 1429321 tcgaaatcaa aagcagtcaa acatttcatg atggaacgag acggaatatg attcatgcag 1429381 gcggaggaac attcggagca agcgcaattg aaaaaatggc aaaaatcatt gcggggctcg 1429441 gtgaacttga gcgccactgg tctattatga aaagttatcc cggttttaaa ccaggcacaa 1429501 atacgattaa cccggcagtt atagaaggcg gcagacatgc ggcttttata gcggacgaat 1429561 gccggctgtg gatcacagtc catttttatc cgaatgaaac ccatgaccaa gtggcagcgg 1429621 aaatagaaga ttacgtcaat cggctgagtg acagtgatat ttggcttagg gaaaaccgcc 1429681 ctgtattcaa gtggggaggc tcatctatga tagaagacag gggagaaatt tttccggcat 1429741 tggaagttga ccctggccac ccaggcgtct tagcgctaac tgcctctcat cagaaagtga 1429801 aacgggagtg tccaattatt gacgtttctc aatcagttac agatggcgga tggctgtatg 1429861 atgccggtat tccatgcgta atatacggtc ctggagatct gcacaatgca cactctgtga 1429921 acgagaaggt atcgattgag cagctagtag agtatacaaa aattatactc gattttatca 1429981 tcagctggtg cagccggaaa aaagaacaat gacatgaaaa tttcttcttg ctgacaaggt 1430041 tcagcctgcc cgttcatata cttgaacaaa aggacggaaa aaggacgtga tggaatgatc 1430101 agcatttcag aatttcaggt aaaggatgtc gtcaatgtct caaacggaaa aaagctgggg 1430161 agtattggtg atattgatat caatgtgacc actggaaaaa ttcaggcgat catactcgga 1430221 ggaaatggga aagttctcgg attttttgga aaagaagagg aattggtcat tccatggcga 1430281 aatatagtaa aaatcgggga agatgtaatc ttagtccgat taagtgaacc acatgcataa 1430341 acctgcttgt ctgccgcaga ttggcaaatg ccggaagtct cgattcttcc ggcacatttc 1430401 atttagaaat atgcaaatcg gcgctcaacg aatgcagtaa gatgtggtaa aataagtggg 1430461 aaattccgct tttttaaatg tttgtcgaaa ggttggatca tcatgaatac atatcaccca 1430521 ttcagtctta ccacaccctc gacactcatg atacaagact gggctcaaac gaatcaaaac 1430581 aacaaagagg tcattgccgg atttacgaca aaaaacggcg gtgtcagcca aaagcctttt 1430641 gaatcgttaa atacaggatt gcacgttcat gacaaagatg cagatgtagt taaaaatcgt 1430701 gaatatattg ccgatatgtt taatactgat ttgcagtctt gggtattcgc tgatcagaca 1430761 catgataatc gcgttcagaa agtgacgcag agggataggg gaaaaggcgc ccgtgagtat 1430821 cacacggctc taaaagcaac ggacgggatc tatacaaatg aaaaaaatgt atttttagca 1430881 ttatgctttg ctgattgtgt gcctcttttc ttttatgatc cggttaagtc gcttgtcgga 1430941 gtcgcccatg ccgggtggaa aggcaccgtc aaacagattg gcagagaaat ggtgaagcaa 1431001 tggactgaga aggaaggttc aaatccctca gatatttacg ctgttattgg cccgtctatc 1431061 agcggagcat gctatacggt agacgaccgc gtcatggatg ctgtccgcgc attgccggtt 1431121 tcagcagacc ttgccgccaa tcagacggca aaggcacaat atcagcttga tctgaaagag 1431181 ctgaaccgtc ttatactgat ggacagcggt ttggcaagtg aacaaatttc tgtcagcggt 1431241 ttatgcacgg aaagcgagcc gtctcttttc tattctcatc gccgcgatca ggggaaaact 1431301 ggacggatga tgtcctttat cggaatgaag gaggcataaa agatcttgcg tgttgttgat 1431361 aatttacgac atataaacga acgaataaac gaagcatgta acagatcggg ccgcagctcc 1431421 gatgaagtta cggttattgc agtcacaaaa tatgtatcac ctgaaagagc acaggaggca 1431481 gtagatgctg gcatcacctg cctcggagag aatcgggatg cggaactgct ccgcaaacag 1431541 gaattgatga aagggaatcc ggaatggcat tttatcggca gtctgcaatc aagaaaagca 1431601 aaatctgtcg tcaattcggt ttcctatatc cattccctag accggctctc attagcgaaa 1431661 gaaattgaaa aacgggctga aggtactgta cgatgctttg tgcaggtcaa tacctctctt 1431721 gagccttcta aacatggcat gaaaaaagaa gaagtcattc cattcataca ggagctttcc 1431781 ggtttcgaac atatccttgt tgccgggctg atgacaatgg ctccgctgac tgatgatcaa 1431841 gatcagatca gaagctgttt caggtcgctg agagaactcc gtgaccaggt tcagaagctg 1431901 aaccagccga acgctccgtg tactgaactg tcgatgggca tgtcaaatga ttttgaaatt 1431961 gcaattgaag aaggagctac ttatattaga atcggctcat cgttagtcgg aaatgaaaca 1432021 gggggtgtac agcaatgagt atgaaaaata aactgaaaaa ctttttctca atggaagatg 1432081 aagaatacga atatgaatat attgagacag agcgggaatc tcatgaggag catgagcaaa 1432141 aagaaaagcc ggcttacaac gggaataaac ctgcgggcaa acagaatgta gtgagcttgc 1432201 aaagtgttca gaaatcctct aaagtggtgt tgagtgagcc gcgcgtttat gcggaggcgc 1432261 aggaaatagc cgaccatttg aagaaccggc gggcagttgt cgtcaatctt cagcggatac 1432321 agcatgacca ggcgaagcgg attgttgact ttttaagcgg aaccgtttat gccattggcg 1432381 gcgatattca aagaatcggc tcagatattt tcctctgcac gcctgacaac gtagatgtat 1432441 caggcacaat ttctgagctc atatctgaag acgaacatca gaggtggtaa agcgagatga 1432501 tcctttatca agttttttcg gttttaagct tattaatcac aatatactca tttgccctga 1432561 tcatatatat ttttatgtca tgggtgccga gtacgaggga aacagcagtc gggcgttttt 1432621 tggcttcgat ttgtgaacca tatctcgaac cattcagaaa aatcatccct ccgattgcaa 1432681 tgctggatat ttcaccaatc gtagcaatac ttgtgcttcg gtttgcgaca accggcttgt 1432741 ggggacttta tcgcatgatt gcgttttaat gtgacagttt gataggggct tggcagcagc 1432801 caagcctctt tacatagaag ggaaagacga tgagcgatat atatcagcac ttcagaaaag 1432861 acgagcgggc ctttattgat caagcgctcg aatggaaaag aattgtccag gagcagtacc 1432921 ggatgaagct gaccgacttt ttagatcccc gagagcaggt catcctctct gctgttacgg 1432981 gacaggcaga tgtcgggctt gccttttccg gcggctatga cagagcggag cggaaacggg 1433041 cgattctgtt tccagagtac attactccgg aagaatcaga ttttgaactg caggcgttta 1433101 acgtccgtta tgctgacaag tttgtctcag tagatcatcg ttctctgctt ggtgcattaa 1433161 tgggcatagg attaaagcgg caaaaattcg gtgacatcgt gttttctgag acagcagtgc 1433221 aattgattgt ctcagccgat accgctgatt ttgtggctgc acagctgacc caagcaggca 1433281 aagcggcggt cagcctagag aaaatcgact tgtcagacct taacattcca gcagttgatg 1433341 tcgaaataag agatgacacg gtttcttctt taaggcttga cgccgtctgc gcctctatga 1433401 gcaggcaatc ccgccagaaa tcacagacgc ttgtgaaaaa cggccttgtg aaagtgaact 1433461 ggaaggtggt tgaagatcct tcatacatag tcgcggaagg ggacatgctg tctatcagag 1433521 gttttggccg gtgcagctta acaaaaatcg aaggaaaaac caaaaaagac aaatggagag 1433581 ttacgtttga acgacaaaaa tagtcggttt ttcagttttt ttctccatct gtgcgaaatt 1433641 tgttttataa tgtgaactag ataaccgtac tgaaatgtaa aaatggaggt ggcatcatgc 1433701 cattaacgcc aaatgatatt cacaacaaga cgtttacaaa aagttttcgc ggatatgatg 1433761 aagatgaagt aaatgaattc ctagcccaag tcagaaaaga ttacgaaatt gttctccgca 1433821 agaaaactga gcttgaagcg aaagtcaatg agcttgatga aagaatcgga cactttgcca 1433881 atattgagga gacattgaat aaatcaattt tagttgctca agaagcggct gaagacgtaa 1433941 aacgcaattc tcaaaaagaa gcaaagctga tcgttcggga agcggagaaa aacgctgatc 1434001 gcattatcaa cgaatcgtta tcaaaatcaa gaaaaattgc aatggaaatt gaagagctga 1434061 aaaaacagtc taaagtgttc agaacacgtt tccaaatgct gattgaagct cagcttgatc 1434121 ttctgaaaaa tgacgattgg gatcatctcc ttgagtatga agtcgacgct gtatttgagg 1434181 aaaaggaata aattctctga ttatcttgac attttcttag cttgtcgaat ataatacgtt 1434241 cataaattca gatgaaaaaa cggttgaaag ggacagtcat gtttccttca ggccttcata 1434301 gcgacccgga gatggtgaga gtccgggatg gccggaatca tgtagatcag ccctttagtt 1434361 tccttgctga actcacagta ggttaggacg ttcatcacgt tacgatgctc aagaggaaaa 1434421 agtgtatgct tgctttttct aaaagggtgg taccgcgaga taagctttct cgtcccttat 1434481 gggatgagag ggcttttttt attttctgaa aaaatgcagt ggaggaatga aaatggattt 1434541 taaagacacg ctcttaatgc cgaaaacaga tttcccgatg cgtggaaatt tgccaaaccg 1434601 tgagcctgac attcaaaaaa aatgggagga agaagatatc taccgtcttg ttcaggaacg 1434661 gacgaaagac cgcccgaaat ttgttttaca tgacggacct ccgtatgcaa acggcgacat 1434721 ccatatgggc catgcactta acaagatttt gaaagacttc attgtccgct ataaatcaat 1434781 gagcggctac aacgcaccgt atgtgccggg ctgggataca cacggattgc caattgaaac 1434841 agctctgaca aaaaacaaaa aggtcaaccg caaagaaatg tcagtagcgg aattccgcaa 1434901 actatgcgaa gagtacgctt ggaagcaaat cgagggacag cgtgagcaat tcaaacgtct 1434961 tggtgtccgc ggtgactggg aaaacccata tgtgacatta aaaccggaat acgaagcgca 1435021 gcaaatccgc gtatttggtg aaatggcaaa acgaggctac atttacaaag gccttaaacc 1435081 ggttaactgg tcaccttcaa gtgagtctgc tctggctgaa gccgagatcg aatatcaaga 1435141 taaacgttca gcatctattt acgtcgcttt tggtgtaaaa gacggaaaag gcgttcttga 1435201 aaacggcgag cgcatcatca tttggacaac aacgccgtgg acaattccgg cgaacctcgg 1435261 aatctcagtg caccctgatc ttgagtacag cgtgattgca gtaggtgaag accgctttgt 1435321 tgtagcaagt gccttagtcg aaaatgttgc atcggcatgc ggatttgatc agtatgaagt 1435381 gacaagaacg gtcaaaggga aagaccttga gaacattatc gctgaacacc cgctatatgg 1435441 cagagactct ctcgttatgc ttggtgaaca cgtaacaact gatgccggaa caggctgtgt 1435501 tcatacagcg cctggacatg gggaagatga ctttatcatc ggccaaaaat acggtttaga 1435561 tgtgctttgc ccggtcgatg aaaaaggtgt aatgacaagc gaagctcctg gctttgaagg 1435621 catgttctat gatgatgcaa acaaagcgat cacacagcag cttgatgaaa aaggcgcact 1435681 tgtgaagctt gaattcatta ctcattctta tccgcatgat tggagaacaa aaaaaccaac 1435741 cattttcaga gcaacagcgc aatggtttgc gtctattaaa gatttcagat cagacctgct 1435801 ggatgccatt aaagaaacca aatgggttcc tgaatggggc gagcagcgtt tgcacaacat 1435861 ggttcgggac cgcggagact ggtgtatttc cagacagcgt gcgtggggtg tgccgattcc 1435921 ggtattttac gctgaaaacg gagaaccggt tattacagat gaaaccattg aacatgtttc 1435981 tgaattgttc agacagcatg gatcaaacat ttggtttgaa aaagaagcaa aggatcttct 1436041 tccggaaggc tttacgcatc ctggcagccc gaacggcaca tttacaaaag aacaggatat 1436101 catggatgtt tggtttgatt caggctcttc acatcaagca gtgcttgaag aacgtgatga 1436161 cctcgttcgc ccggctgatc tatacctaga gggatctgac caatatcgcg gctggtttaa 1436221 ctcttctctt tctacagcag tagccgtaac agggaaagcg ccgtataaag gtgtgctcag 1436281 ccatgggttc gcactggatg gagaaggacg taagatgagt aaatcaatcg gtaacgttgt 1436341 tgttccggct aaagtcatga aacagcttgg tgccgacatc ttaagattat gggtatcttc 1436401 agtggattat caggcggacg ttcgcgtgtc tgacgccatt ctgaagcagg ttgcggaagt 1436461 atatcgtaaa atccgcaaca cgttccgttt ccttcacggc aaccttttcg attttgatcc 1436521 aaaaacaaat gcggtggctg tcgaagatct tcgcgaagtg gatcagtata tgctgattaa 1436581 gctgaacaag ctgattgata aagtgaaaaa agcgtatgat gagtacgaat ttgcggttgt 1436641 gtatcacagc attcataatt tctgcacaat cgaattgagc tcattctacc ttgattttgc 1436701 aaaagatatt gtctacatcg agcatgcgga tcatccggat agacgcagca tgcagacagt 1436761 attctacgaa acgcttcttg cattagtgaa gctttcagcg cctatccttc cacatacggc 1436821 agacgaattg tggtctcatt taacatttgt tgaagagcag agcgttcagt tgaccgatat 1436881 gccggaaaca atcacggttc caaacagtga agcgactgaa gaaaaatttg accgctttat 1436941 ggctcttcgt gatgacgtgt taaaagcatt agaaactgcg cgaaatgaaa aaattatcgg 1437001 taaatctttg gaagcaaacc tgaaattgta tccaaacaaa gaaaacaagg agctcttggc 1437061 ttccataaaa gaaaaccttt ctcagctgtt tattgtgtct gaactgacaa tcagcgaaga 1437121 aaatgaagcg ccgaacgatg cgcaaagctt tgcgacgggt aaaatcgctg tcgagaaagc 1437181 ggaaggcgaa atgtgtgaga gatctcgtgt gatttcaaaa gatgtagggg caaatccgaa 1437241 atatcctaca ctttcattac gcaacgctga aatcgttgaa aaatactatc aaaaataatg 1437301 caaaagagcc cggcgtaaaa gccgggcttt ttttgtgcca agagtgacat cctttagaac 1437361 gaaaggaaaa atcttatggg ctttagatca tcattcacag gcaacaataa agatactacg 1437421 ttaagagcag gagttgtgaa gaatgaatga tcaactgacc gcaatttata cggaacttct 1437481 tctgatgaaa gaagaattac agtcgagatt atttgagtat tcttgctttc aggtttctac 1437541 aagcccgcaa gcagcaatca atcaaaaaca aaaagcaact ctgatctatc atattaaaga 1437601 agaacttcaa gacgttctcc ttgcattgtc caaaatcgaa aacggcacat tcggatactg 1437661 tgaagaaact ggggccccca ttcctcttgc aaagctggca gtgctgccga cggcccgaac 1437721 agcaaacgat tttctttatt ctgtccaatt tgagaaaaaa acgcttccga tatggaaatc 1437781 aacggatatc gaatatggtc aggcactgta tgaataacag tgtctgtccg gttaatatgc 1437841 ctgatatttc tttactccag tgctttttat tgataaaatg cataatggat taaagtaacc 1437901 gtaaactgga ggaacgtttg tgctgtatta tatgattgca ctacttatta ttgcagccga 1437961 tcaattgaca aaatggctag ttgttaagaa catggaactt ggccaaagca ttccgatcat 1438021 tgatcaggta ttctatatca cctcccatcg caatacgggt gctgcatggg ggatattagc 1438081 gggtcaaatg tggtttttct acctcataac aaccgctgtt attattggta ttgtttatta 1438141 catacagcgt tatacaaagg gacaaaggct tcttggcgtt gccctcggac ttatgcttgg 1438201 cggtgccatc ggcaacttta tcgatcgggc tgtcagacag gaagttgtgg attttatcca 1438261 tgttattatt gtcaattaca attacccgat atttaacatc gcggactctt cactatgtgt 1438321 cggcgtaatg cttttattta tacaaatgct gttggacagc gggaaaaaga aaaaggagca 1438381 atagcatgaa tcaaattgat ataaccgctt cagaagaaca aaaaagtgag cggattgata 1438441 aatttttggc atcgactgag aatgattggt caagaaccca ggttcagcaa tgggtaaaag 1438501 acggacaggt tgtcgtgaac ggaagcgcgg tgaaagcgaa ttataaaatt cagccgggtg 1438561 atcaggtgac cgtcactgta cctgaaccgg aagcgctcga cgtcctggca gagcctatgg 1438621 atctggatat ttattatgag gaccaggatg tgctggtcgt caacaaacct cgcggaatgg 1438681 ttgttcaccc agcacccggg catcttacgg gcacacttgt aaacggtctt atggctcatt 1438741 gcacagacct ttccggaata aatggtgtga tgcgcccggg tattgttcac agaatcgata 1438801 aggacacgtc cggtttatta atggtggcga aaaatgatat ggcgcacgag tcactcgtaa 1438861 accaattggt caacaaaacg gtcacgcgga aatatacggc ggttgtccac gggcttattt 1438921 ctcatgatga cggcacaatt gacgcgccga tcggacggga taaaaaagac cgtcaaagca 1438981 tgactgtgac acgtgatggc aaaaacgctg tcactcattt tcatgtgctt gagcgttttc 1439041 aggattttac gttagtggag tgccagcttg aaacagggag aacccatcaa attcgtgttc 1439101 atatgaaata tatcggattc ccattagcag gcgatccgaa atacggccca agaaaaacaa 1439161 tcgactttaa tggccaagcg cttcacgcgg gagttttagg ttttgaccat ccacgaacag 1439221 gagaatatgt cgaatttgaa gcgccgcttc ccgaggatat ggcagaatta atcgaaaacc 1439281 tcagaaaaaa cggttgacag agggtttctt ttctgaaata ataaacgaag ctgaatagat 1439341 tctttaaaac agtccagaga ggctgagaag gataacggat agacgggatg cgtgtatagg 1439401 cgcgcacctt gtcctaaaac ccctctatgc tctggcagga ggggtttttt cttctatatg 1439461 aactgtgagg tgtcacacat tgaatcaaaa agctgtcatt ctcgacgaac aggcaattag 1439521 acgggcgctg accaggattg ctcacgaaat gatcgaacgc aataaaggaa tgaataactg 1439581 cattcttgtc ggcattaaga caagagggat ttacctggca aaacgccttg cggaacgcat 1439641 tgaacagatt gagggaaatc ctgttacagt cggtgaaatt gatattactc tttacagaga 1439701 tgatctttct aaaaaaacaa gcaacgatga accgcttgta aaaggtgcag atattccggt 1439761 agatattaca gatcaaaaag tcattctcgt tgatgatgtt ctgtataccg gaagaacagt 1439821 cagagcagga atggatgcgc ttgttgatgt aggcagacct tcctccattc agcttgcagt 1439881 gcttgtggac agaggacacc gggagctgcc gatccgagcg gattatatcg ggaaaaacat 1439941 cccgacatca aagtctgaaa aggttatggt acagcttgat gaggtagacc aaaacgatct 1440001 cgtcgccatt tatgaaaacg aataatagat caccttttta agggcaatcc agagaggttg 1440061 caaagaggtg cacaacaaag gcccaaaaag tattcggcag gtctttgtat gcctctttgc 1440121 gtaaaaaagc aaagaggttt ttttatacag tcattgagtc atcctaaaat gaaagtcaac 1440181 aatcaggggg aaatcatcat gagtaagaaa aaagtaaatt taggggtcag ggatgtcccg 1440241 acacctttct cttgggtttc attcagcctt cagcatttgt ttgccatgtt tggctcaacc 1440301 attttggttc cgaagctcgt cggaatgagt cctgctgtgg cgttggtgac aagcggcatc 1440361 ggaacactgg cgtaccttct tattaccaaa ggacaaattc cggcgtatct cggttcatcc 1440421 ttcgccttta tttctccgat cattctggta aaagcgaccg gcgggccggg agcggcaatg 1440481 gttggagcgt ttcttgcagg gctggtgtac gggctgattg ccttattgat taggcagctt 1440541 ggaacaggat ggctgatgaa gattctcccg cctgtagtcg tagggcctgt tattatcgtc 1440601 atcgggctgg gactggcaag cactgcagta aacatggcga tgtatgctga tccgaacgcg 1440661 agtgagttgg tctacagctt aaagcacttt agtgtcgcag gagttacgct ggcaattacg 1440721 attatttgtg cgattttctt acgagggttt ttaagcctga ttccggttct gatcggaatc 1440781 atcggcggat acctgtttgc ccttactcaa gggattgtca acttccagcc ggtgcttgac 1440841 gcgaaatggt ttgcagtgcc tgaatttatc attccgttca aagattattc accgtcagtt 1440901 acgctcggca tcgcagccgc aatggttcct gtcgcatttg tcacaatgtc agagcatatc 1440961 ggccaccaaa tggtgctgag caaggttgtc ggacaagact tcattaaaaa gccaggtctt 1441021 catcgctcta ttatgggtga cagtgtggcg acaatcctcg cttccctgat cggcggccct 1441081 ccgacaacga cttacggaga aaacattggc gtgctggcca tcacaagagt attcagcgtc 1441141 tttgtcatcg ggggcgcggc agtgattgcc ctttgcttcg gctttatcgg caaaatttca 1441201 gcgctgatca gttcagtgcc gtcagcggtc atgggaggcg tctccttcct gctgttcgga 1441261 atcattgctt caagcggcct gagaatgctg attgacaaca aaattgatta tgaaaacaac 1441321 agaaacctca ttattacatc agttatcctt gtcatcggtg taggaggcgc ttttatccaa 1441381 gtgtctcagg gcggattcca agtgtcagga atggcgcttg ccgcaattgt cggtgtcatc 1441441 ttaaacctga ttcttccgca ggcgaaggaa gagcaggcag acacatctga acaacatcat 1441501 atttaaaacc ttttaatgaa agtccagaga ggcttggaag ggttatgaag agaaggaagc 1441561 ttcaatgctg ccctctattt aaccataccc cgagtctatc ttagaccggg gttttttttc 1441621 agccttaagt tgaaaagaga ggggaaagaa catgaagcat ttaacgacga tgagtgaact 1441681 tagcactgag gaaatcaaag atttgcttca aacagcacaa gagctcaaaa gcggaaaaac 1441741 agacaatcag cttacaggaa agtttgcagc aaacctgttt ttcgaaccga gcacgagaac 1441801 gcggttcagc tttgaggtcg cagaaaaaaa gctgggcatg aatgtgctta accttgatgg 1441861 aacaagcaca agcgtgcaaa aaggcgaaac cttatatgac acgatccgga cgcttgaatc 1441921 aatcggtgtg gacgtctgcg tcatcaggca cagtgaggat gagtattatg aagagcttgt 1441981 cagccaggtg aacattccga ttctgaatgc gggagacggg tgcggccagc atccaacaca 1442041 atcactgctt gatttaatga cgatttatga agagttcaat acgtttaaag ggcttaccgt 1442101 ctccattcac ggcgacatca agcatagcag agtggcaagg tcaaatgcgg aagtgttgac 1442161 aagattgggt gcccgggtcc tattttccgg cccttcggaa tggcaggatg aagaaaatac 1442221 attcggcacg tatgtctcaa tggatgaagc agttgagtct tccgatgttg tcatgctgct 1442281 gcgcattcaa aatgaacgac atcagtccgc tgtcagtcag gaaggctatt taaacaaata 1442341 cggcttgacc gtagaacggg ctgagcgtat gaagcggcat gcgatcatca tgcatcctgc 1442401 tccggtaaac agaggagtgg agattgatga cagcttagta gaaagcgaaa aatcaagaat 1442461 cttcaagcaa atgaaaaatg gcgtatttat cagaatggca gtgatacagc gtgccttaca 1442521 aaccaatgtg aaaagaggag aagcagcgta tgtcatatct cattaaaaac ggctggatac 1442581 taaacgaaaa tggtgaaaaa acacaagcgg atatccgagt gactggagaa accatcaccg 1442641 caatcggcaa gcttgatgca acggataatg aaacggtaat tgatgcaaaa ggtttgctcg 1442701 tttcacctgg gtttgttgat ctccacgtgc atttcagaga gccgggcgga gagaaaaaag 1442761 aaactattga aaccggggca aaagcagcgg cgcgcggcgg ctatactaca gtagcagcaa 1442821 tgccgaatac gcggccggtt cctgatacaa aggagcagat ggaatgggtg caaaacagaa 1442881 ttaaagaaac atcatgcgta agagttcttc catatgcatc cattacgatc agacaaatcg 1442941 gcgatgaaat gacaaacttt gaagcgttaa aagaagccgg ggcatttgct tttacagatg 1443001 acggcgttgg tatacagaca gcaggaatga tgtatgaagc gatgaaacgg gcagccgcaa 1443061 ttgacaaagc gattgttgca cattgcgagg acaactcctt aatttacgga gggagcgtac 1443121 atgaggggac attctccaaa gcgaacgggc taaacggcat tccttctgtg tgtgaatcgg 1443181 ttcatattgc tcgcgatgtg ctgctggctg aggcggcaaa ctgccattat catgtatgcc 1443241 atatcagcac aaaagaatct gtcagagttg tacgcgatgc gaaaaaagcg ggaatcagag 1443301 tgacagcaga agtatcgccg catcatttgc tgctttgtga tgaggacatc ccggggctgg 1443361 acacaaacta taaaatgaat cctccgctcc gcagcccaga agacagagct gctttaattg 1443421 aaggtctttt agacggaaca attgatttta tcgcaacaga ccatgcaccg catacggaag 1443481 aagagaagaa cacagaaatg aagctggcgc cattcggaat tgtcggctta gaaacagcat 1443541 tcccgcttct ttacacacac tttgtcaaaa atggcagctg gtcactgaag cagctgattg 1443601 actacatgac aatcaagcca tgcgaagcgt tcggtctccc atatggaaca ttacaaacgg 1443661 ggcaagctgc ggacattacg ttaatcgatt tagaaaaaga agcagttata gacaaagaga 1443721 catttttatc aaaaggaaaa aatacaccat tcaacggcat cagttgcacc ggctggccgg 1443781 tcgctacaat tgcggcaggg aagcttgctt atgaagaggg gagacttgtc aaatgaagag 1443841 acgattagta ctggaaaacg gagcggtatt cgagggagaa gctttcggaa gcttagaaca 1443901 caacatggga gaagtcgttt ttaatactgg gatgacaggc tatcaggaaa ttttatctga 1443961 tccttcttac tgcggacaga tcgtaacatt aacatacccg cttatcggaa attacggcat 1444021 taaccgtgat gattttgaat ccattacccc ttttgtcaaa gggctgatca tcaaagaatt 1444081 atgtgagctg ccttccaact ggcgttcagc atacacctta gacgagtatt taaaaatgaa 1444141 aaacattccc ggactccagg gaattgatac aaggaagctg acaagaatga tccgcacggc 1444201 aggcgcgcta aaaggaacat tcgcttcatc tgatgaagat atcgaagcag tgctgaaaag 1444261 actgaacgaa acggaattgc caagaaatca agtatcccaa gtatcagcaa aaacagcata 1444321 tccgagcccg ggaagaggca aacgcattgt cttggttgac ttcggcatga aacacgggat 1444381 tctaagagag ctgaacaaac ggaaatgtga cgtcatcgtt gtgccttaca acattacagc 1444441 ggaagaggtg cttcagctga aaccggacgg tatcatgctt tctaacggac ctggagaccc 1444501 gaaggatgtg cctgaagcga ttgaaatgat taaaggtgtt cttggaaaag tgccattatt 1444561 cggaatatgt ctcggccacc aattattcgc gctggcgtgc ggggcgaata ctgaaaaaat 1444621 gaaattcggc cacaggggct caaaccaccc ggtaaaagag ctggctacag gaaaagttgc 1444681 cttaacatct caaaaccatg gatatacagt ttcgtctatc agtaaaacag aactggaagt 1444741 gacgcatatc gcaattaacg acgatacgat tgaagggctg aagcataaaa cattgccggc 1444801 atttacggtt caatatcatc ccgaagcctc acctggtcct gaggatgcca accatctatt 1444861 tgacagattc atcgaaatga tcgaaacaac agagaaagaa ggggaagcgg tatgccaaaa 1444921 cgcgtagaca ttaacaaaat tttagtaatc ggatctggac cgatcatcat cggccaagca 1444981 gcagaatttg actatgcggg aacacaagcc tgtcttgctt tgaaagaaga aggctatgaa 1445041 gtcatccttg tcaactcaaa ccctgcaacg atcatgacag atacagaaat ggctgaccgg 1445101 gtttacatcg aaccgctcac acctgaattc ctgacacgaa tcatcagaaa agagcgcccg 1445161 gatgccattc ttcctacact cggaggccaa accggtttga atcttgcggt tgagctttct 1445221 gaaagaggcg ttttggcaga atgcggcgtc gaagtgcttg gcacgaaact gtctgcgatt 1445281 cagcaagctg aagaccgtga cttgttcaga acattaatga atgaactgaa tgaaccggtg 1445341 cctgaaagtg agattatcca ctcccttgaa gaagcagaaa aattcgtcag tcaaattgga 1445401 ttccctgtca ttgtccgccc ggcatataca ttaggcggaa caggcggagg catctgctcg 1445461 aatgaaacag agctaaaaga aatcgttgag aacggcttga aattaagccc ggtacaccaa 1445521 tgtctgcttg aaaaaagcat cgccggctat aaagaaatcg agtatgaagt catgagagac 1445581 agccaggatc acgccattgt cgtttgtaac atggaaaaca ttgatccagt tggaatccat 1445641 actggagaca gtattgttgt cgcgccgagc caaacgctca gcgatcgcga atatcagctc 1445701 ttgcggaatg tatcgttaaa actgattcgc gcgcttggga tcgaaggcgg atgtaatgtc 1445761 cagctcgcct tagatccaga cagcttccaa tattacatta ttgaagtaaa tccgcgtgtc 1445821 agccgttcat ctgcccttgc atcaaaagca acggggtacc cgattgcaaa gctcgctgct 1445881 aaaattgcag tcggactttc attagatgaa atgatgaacc cggtgacagg aaaaacatat 1445941 gcagcatttg aacctgctct tgactatgtc gtatccaaaa ttccgcgctg gccgtttgat 1446001 aagtttgaat cagcaaacag aaagcttggc acgcaaatga aagcgacagg tgaggtcatg 1446061 gcaatcggcc gcacgcttga agagtcattg ctgaaggcag tgcgatcact ggaagcggat 1446121 gtgtatcatc ttgaattgaa ggacgccgct gacatttcag atgagcttct tgaaaagcga 1446181 attaaaaagg ccggtgatga acgcttattc tacttagctg aagcgtacag aagaggctac 1446241 acggtagaag acctccatga attttccgct atcgatgtct tcttcttgca taagctgttc 1446301 ggaatcgtac agtttgaaaa agaattgaag gccaatgcgg gcgatacaga tgtgctgaga 1446361 cgggcaaaag aactcggctt ctctgatcag tacatcagcc gtgaatggaa aatgaaagaa 1446421 tctgagcttt acagcttgag aaaacaagcg gggattgcgc cggtattcaa aatggtagat 1446481 acatgcgcgg cggaatttga gtcagaaacg ccatacttct atagcacata tgaagaagaa 1446541 aatgaatctg tcgttacaga taagaaaagt gtgatggtgc ttggttcggg tccgattcga 1446601 atcggtcagg gtgtcgagtt cgactatgcg acggttcact ctgtatgggc aattaaacaa 1446661 gcaggctatg aagccattat tgtcaacaac aacccggaaa ccgtttcaac agacttcagc 1446721 atctcagaca agctgtattt tgaaccgctt acgattgaag atgtcatgca catcattgac 1446781 ctcgaacagc caatgggcgt tgtcgtacaa tttggcggac aaactgcgat taaccttgct 1446841 gacgagcttt ctgcacgcgg agtgaaaatc cttggaactt cattagaaga tttagaccgt 1446901 gccgaagacc gggataaatt tgaacaagcg cttggagaac ttggtgttcc tcagccgctt 1446961 ggcaaaacag cgacatcagt taatcaggcg gtaagcatcg caagtgatat cggttatccg 1447021 gtactggtac gcccttccta tgtacttggc ggccgggcga tggagattgt ttaccatgaa 1447081 gaggaactgc ttcattacat gaaaaatgca gtcaaaatca atccacagca ccctgtatta 1447141 attgatagat acttgaccgg aaaagaaatt gaagtcgatg cagtatccga cggtgaaaca 1447201 gtcgtcattc cgggaattat ggagcacatt gaacgtgcgg gcgttcactc cggagactca 1447261 atcgctgttt atccgcctca gtctctcaca gaggacatta agaaaaaaat tgaacaatac 1447321 acgatcgcat tggctaaagg gctgaatatt gtcggtttgc tcaatattca attcgtcttg 1447381 tcgcaaggcg aggtgtacgt gctagaagtg aatccgagat caagcagaac cgtaccgttt 1447441 ttaagcaaaa ttacgggtat cccaatggcg aatctcgcaa caaaaatcat tcttggtcaa 1447501 aagctggctg cgtttggcta tacagagggc cttcagcctg aacagcaagg tgtatttgta 1447561 aaagcgccgg tcttctcctt tgccaagctg agaagagtgg atattacgtt agggcctgaa 1447621 atgaaatcaa caggtgaagt catggggaaa gattcgacac ttgaaaaggc gctctacaaa 1447681 gccttgatcg cttcaggtat tcaaatcccg aactacggtt ccgtgctttt aacagtagct 1447741 gataaggaca aagaagaagg gcttgccatt gctaagcggt tccacgcgat cggctacaac 1447801 attttagcga cggaaggaac ggcaggctac ctgaaagaag cttccattcc agcgaaggtc 1447861 gtcggaaaaa tcggtcagga tggcccgaac ttgcttgatg tcatcagaaa cggagaagcg 1447921 cagtttgtca tcaatacgct gacaaaagga aagcagccgg caagagacgg ttttagaatc 1447981 agacgtgaat cagtagaaaa tggtgttgcc tgcctaacat ctttagatac ggcagaggcg 1448041 atattgcgag tgctggaaag catgacattc cgtgctgatc aaatgccggc agtcaacaca 1448101 aatcaggagg cggcagtcac tatatgaaaa aagcgtattt gacagtatgt tctaaccagc 1448161 aaattgcaga ccgggtgttt caaatggttc tgaaagggga gcttgtccaa gggtttacaa 1448221 cccctggaca gttccttcat cttaaagtga gcgaagcggt tacgcctctt ttgagaaggc 1448281 cgatcagcat cgcagacgtc aactttgaaa aaaatgaagt caccatcatt tatcgggtag 1448341 atggggaagg gacaagactc ttgtcactga agcagcaggg agaacttgtg gatgtcctcg 1448401 ggcctttggg aaatggcttt cctgttaatg aagttcaacc cggaaagacg gctttgctgg 1448461 taggaggcgg agtaggtgtg ccgcctctcc aagagctgtc gaaacgcttg attgaaaaag 1448521 gggtaaatgt catccacgtt ttaggattcc aatcggcaaa ggatgttttt tacgaggaag 1448581 aatgccggca gtacggagac acgtatgtgg caacagctga cggaagctac ggggaaaccg 1448641 gatttgtcac agatgtgatt aaacggaaaa agctagagtt tgatatcctc ctcagctgcg 1448701 ggccgacacc gatgctcaag gcgttaaaac aggaatatgc ccataaagaa gtatatctgt 1448761 ccatggagga acgaatgggc tgcggaatcg gcgcatgctt cgcgtgtgtg tgccatacaa 1448821 acgaaagtga gacatcctat gtaaaagtat gtctcgacgg gcctgtattt aaagctcagg 1448881 aggtggcgct gtaatgctag aggtgaaatt gccgggactt gatttgaaaa acccaatcat 1448941 tcctgcatca ggctgcttcg gttttggaaa agaattttca cgtttttatg atttgtcttg 1449001 tcttggagct atcatgatta aggctacgac aaaggagccg cgctttggga atccgacgcc 1449061 gcgggtagct gagactggtg ctggaatgct caatgcgatc ggtctccaaa atccggggct 1449121 ggatagtgtg ttgcatcatg agctgccgtg gcttgagcag tttgatacac cgatcattgc 1449181 caatgtcgca ggttctcaag tcgatgatta tgttgaagtc gcagaacata tcagcaaagc 1449241 gcctaatgtt catgctcttg aattgaatat ttcctgcccg aatgtgaaaa caggcggaat 1449301 cgcttttggc acgaatcctg aaatggctgc cgatttgaca aaagcggtga aagaggtttc 1449361 ggatgtaccc gtttatgtga agctatcccc gaacgtggct aatatcacag aaattgcatt 1449421 agcgatcgag gaagcgggag cggacggtct tacgatgatc aacacactaa tcggcatgag 1449481 actcgattta aaaaccggca aaccgatatt agcgaataaa acagggggac tttcgggccc 1449541 tgctgtgaag ccggttgcca ttcgcatggt gtatgaagtc agccagatgg tcaacatccc 1449601 gattatcgga atgggaggcg tgcaaacggc tgaagatgcc ctggaatttc ttctcgcggg 1449661 agcaagcgca gtcgctgtcg gaacagcaaa ctttgtgaat ccttttgcat gtccagagat 1449721 tattgaacag ctcccatctg ttttgctcca atacggctat caatcaattg aagaatgcat 1449781 cggaaggagc tggaatcatg aaaaacaacc tgcccatcat cgcgcttgat tttgcgtcag 1449841 ctgaagaaac acttgcgttc ttagcgcctt ttcagcaaga accgttattt gtaaaggttg 1449901 ggatggagct tttttatcaa gaagggccat ctatcgtgaa acaactaaaa gaaagaaact 1449961 gcgagctatt tttagatcta aagcttcatg acatcccgac tactgtaaac aaagcgatga 1450021 agcgccttgc cagtcttgga gtagacctcg tcaatgttca tgctgccggg ggcaaaaaaa 1450081 tgatgcaggc agctctcgaa ggcttagaag aaggtacgcc ggctggaaaa aaacgtccgt 1450141 cacttatcgc ggtaacccag ctgacaagca catctgaaca aatcatgaaa gatgaactgc 1450201 tgatcgaaaa gtctctgatt gatacggttg tgcactacag caaacaggcg gaagaaagcg 1450261 gactggatgg agtggtctgc tctgttcatg aagcaaaagc catttaccaa gcggtgtcgc 1450321 cttcatttct gactgtcact ccggggatca gaatgtcaga ggacgctgcg aatgaccaag 1450381 ttcgcgtagc gacgcctgcc attgcaagag agaaaggttc atcagcgatt gtagtaggac 1450441 gctcgattac aaaagcggaa gacccggtaa aagcctataa ggctgtcaga cttgaatggg 1450501 agggaatcaa atcttgaaac aaatcatcgc aaaacatcta ttagacatcc aagctgtatt 1450561 tttacgcccg aacgagccgt tcacatgggc aagcggcatt ttatcaccga tctactgtga 1450621 caaccgcctt acgctatctt tcccagaggt cagaaacgat gttgcttcag gtatcagcaa 1450681 gcttgttaaa gagcattttc ctgaagctga aatgattgcg ggaacagcaa ctgccggtat 1450741 tcctcatgct gctcttgcgg cggaccattt gaatcttccg atgtgttatg tgaggagcaa 1450801 gccgaaggcg cacggaaaag gcaatcagat tgagggagct gtgcaagaag ggcaaaaaac 1450861 agtcgtcatt gaagacttaa tttccacagg aggcagcgtg cttgaagctt gtgcagcttt 1450921 acaagcggcc ggctgtgaag tgcttggtgt cgtctcaatc tttacgtacg gacttcctaa 1450981 agcggaggaa gccttcgcaa aggcagaact gccatactac tcattaaccg attatgatac 1451041 gctcacagag gtcgcgcttg aaaacggaaa tattcattca gatgatctaa aaaagctgca 1451101 aacatggaaa cgaaatcccg agtcaaaaga ttggtttaaa aaataaaaaa taaattcaaa 1451161 tgatgtaaag aggcttcaaa gccttgctgt acttgaaaac aggctgtgag gcctgttttt 1451221 ttattaatcc tataaaaaaa gtcgggttga cttatgttag aattgtgcta aaatttacta 1451281 caaatctaaa aacttatcaa gagcggctga gggactggac ctatgaagcc cggcaacctg 1451341 catagtttgt aaggtgctac ttccagcaaa atgaattcca ttttgaaaga taagggctgc 1451401 atgctgttcc tgtctttctt tccgccggat tgaaagtttt ttattttaag aggtaaaaag 1451461 gctatctgta tatcagcagc cgcgaatcac attacatggg aaaagacaac cggcagaaag 1451521 ctactgtttg tttgtctccg aaaggaggaa agaagaaatg ttaacgtatg ataattggga 1451581 agaaccaacg attacatttc cggaagacga tccttataaa ggagcgctgt cagttttaaa 1451641 atgggcatac ggccattacg gcgatcagct tgtttatgcc tgcagtttcg gaattgaggg 1451701 aatcgttctg attgacttaa tttataaagt gaaaaaagac gcagagattg tgtttcttga 1451761 tacaggactt cattttaaag aaacctatga aacaattgaa cgagtgaaag agcgttatcc 1451821 gggtcttaat atcatcctga aaaaaccaga tctcaccctt gaggaacaag ccgaagaaca 1451881 tggtgacaaa ctatgggaaa gagagccgaa tcagtgctgc tatcttagaa aggtcgttcc 1451941 tttaagagag gcgctttcag gacatccagc ctggctttcc ggcctgcgcc gtgatcaagg 1452001 gccaagccgt gccaatacga atttcttaaa caaagatgaa aaattcaagt cagtaaaagt 1452061 ttgcccgctt atccattgga cttggaaaga catttggaga tatacatccc ggaatgaact 1452121 ggactacaat ccgcttcatg accaaggcta tccaagtatt ggctgtgcgc cttgcacttc 1452181 tcccgctttt acagcagaag atttgcgctc aggcagatgg aatggtatgg cgaaaacaga 1452241 atgcggactg catgaataag gagctgcaaa atggaattag ccgctatttt atttagcttg 1452301 tttttcgcga tgaatattgg tgcaagcggc gctgcagctt cgatgggggt tgcttacggc 1452361 tccggagcca tcaaaaagaa aacttacgct ttgatcctat gcgcagtcgg tgtctttgcc 1452421 ggggcggtca ttggcggagg cgaggttgta aaaacaatca gctccggcat tattcctgag 1452481 cagacgatta cactgacgat tgtttgcatc attattggag ctgctgccct gtcgctcttt 1452541 actgctaatc tgctcggcat tcctttgtcg acaagtgaag taacagtcgg cgcggttgtc 1452601 ggcgtgggag tggcttataa agtattgttt gtgaacaatc ttctgatcat tgtgtcattt 1452661 tgggtttttg tcccgctgtt cgctttcggc ttcacctatt tcgtatctaa gctgtttcgt 1452721 tattttaaga ttgaagtaaa atcttctaaa aagcaaaaaa tcctcggcat tgttttgtta 1452781 gttgccggat ttttcgaagc attctctgcc ggcatgaata acgtggcgaa tgctgttggc 1452841 ccgttagtag ctgccggtgt gcttgatgtc ggaaaaggaa ccttgtatgg aggagctttt 1452901 gttgctcttg gcgcactgtt attaggccgg cgagtgctag aaacaaacgg gaagaaaatt 1452961 acgaggttct ccaaagggga aggcattctc ttatccggta caggagcggg actggtgatc 1453021 atcagttctg tatttgggat gccggtgccc ttggcgcaag tcacgtcatc gtctattatc 1453081 ggaataggca tggcgaaaaa cggtccgaac gtgttccata aacaagttgt tcaaacgatg 1453141 ctgaaggtat ggatcgtatc gccgttttta tctttatcga tttcttatct gcttgtatcc 1453201 ttgtttttaa aagcagatta ttattcgatc tttatcatgg taagtgtgct tttagcggcg 1453261 ggcggtgcca tcagcctgac aaaggccatt cgtaaagaga gacgctcagt ccacgaacaa 1453321 ggcgggggaa tctgatcatt aatctgagta attttataag ttaactagga ggagatggat 1453381 attatgagct tagcaccaca cggaggaaca ttagtaaaca gagtagatga atcatatgat 1453441 gtgagcggca ttcaaaaaga aattgaactt gatttaattt ctttcgcgga tttggaattg 1453501 atcggtatcg gtgcatacag cccgattgaa ggtttcttta atgaaaaaga ttacgtatca 1453561 gtggtcgaaa acatgcgtct ttcttccggc gttgtctggt ctcttccaat cacgcttccg 1453621 gtcgatgcgc aaaaagcagc ggaactgtca cttggtgaaa cggtaaagtt aacgtatgaa 1453681 ggagaaactt acggcgttat ccaaatcgaa gacctgtacg tgcctgacaa acaaaaagaa 1453741 gctgtcaatg tgtacaaaac agatgaacag gagcatcctg gtgttaaaaa gctgttcagc 1453801 cgcggcaata catatgtcgg cggaccgatt acgttgatta aaaaagcttc aaaacagttc 1453861 cctgaattta catttgaacc gtcagaaacg agacgccagt ttgcggaaaa aggctgggaa 1453921 accattgtcg gtttccaaac aagaaaccct gttcacagag cgcatgaata cattcaaaaa 1453981 acggctcttg aaacagtaga cggcttgttc ttgaatccgt tagtaggtga aacaaaatct 1454041 gatgacattc cagctgatgt acggatggaa agctaccaag tgcttcttga tcattattac 1454101 ccgaaagatc gtgttttcct tggtgtcttt ttagcggcga tgcgttatgc aggcccgaga 1454161 gaagcaattt tccacgcgct tgtcagaaag aactacggct gcacacattt catcgtcggc 1454221 cgtgatcatg caggtgtagg cgactattac ggaacatacg aagcacagga actgtttgac 1454281 acatttaaac ctgaagaact cggaattaca ccgctgaaat ttgagcacag cttcttctgt 1454341 aaaaaatgcg gaaatatggg aacagcaaaa acttgccctc atggcagaga gcatcacgtc 1454401 attttatcag gcactaaggt aagaggtatg ctgagagacg gtgtgctgcc gcctgctgaa 1454461 ttcagtcgaa aagaagtagt agaagtgtta atcaaaggga tgaagaaaaa agaagaagta 1454521 ggcgtatctt aaggaggact ggcagtgaca aatcgcgata ttgtatggca tgaagcctct 1454581 atcacaaaag aagagtatca gcaaaaaaac aagcataaaa gctccattct ctggctgaca 1454641 gggttaagcg gctcaggcaa atcaaccatt gccaacgccg ctgcgagaga attgtttgag 1454701 caaggctacc aagtcattgt gctggacggg gataatatcc gtcacggcct aaatagggat 1454761 cttggttttt ctgatgaaga ccgaaaagaa aacatccgcc ggatcggaga ggtggcgaag 1454821 ctttttgttc agcagggaac cattgtgatt actgctttta tctctccttt ccgcgaggac 1454881 agacaacagg ttcgcgagct tgtggaagcg ggcgaattta atgaagtcta cattaaatgc 1454941 gaccttgata tttgtgaaca aagagatccg aaagggcttt acaaaaaagc aagaaacggc 1455001 gagattccgt tctttacagg aattgattct ccttatgaag aaccggaagc tccagagctc 1455061 gttcttgatt caggacagca tgaccgtgaa gcgtgtaaaa atcagctgat cgagtttgtt 1455121 aaacaaaaat tgagctgaat atgatctgct gcgttcttct cagatgccgg aatgcaagcg 1455181 agaacatcat cacagcgaat cttctggaag aactcgaata gatcggggga aatacgatgg 1455241 ggaaagtata tattgtagga gcgggtcccg gtgaccctga tctgctgaca attaaagcgc 1455301 tgaaagccat tgaaaaagct gatgtcatct tatatgacag attagtaaat aaagagattt 1455361 tacaatatgc caaagagcaa gcagacctga tctactgcgg gaagcttccg gattttcata 1455421 cgatgaagca ggaaaccatc aatcgatttc ttgtgaagta tgcgcaaaaa gggaaaatgg 1455481 ttgtcagact gaaaggcgga gacccttttg tgttcgggag aggaggggaa gaagcggaat 1455541 gcctctctga aaatggaatt ccgtttgaaa tcattcccgg cattacgtct ggaatcgcgg 1455601 cagccgctta tgccgggatt cctgttaccc atcgggatgc gggctctaac gtcgcttttg 1455661 taacgggtca ctataaaaaa gaagaagatt ttgaggaaaa gtggaaagcg ctggctacag 1455721 gaattgatac acttgtcatc tatatgggta tcaaaaacgt gcagcagatt gaaagaaaac 1455781 tccttgaaaa tggccgggac ggttctacgc cagcagcctt tattcattgg gggacaacgg 1455841 acaagcaaaa atctgttttt tgtacagttg acaccctttc agaaacggtg ataaaagaaa 1455901 acattacaaa tccgagttta attgtcattg gaaatgttgt aaattatcac tataagctgg 1455961 aatggtttga atctgaacta aaaaaacaag atttaagcga ggcgttgtaa aaatgaaaca 1456021 agcaatttta tatgtcggcc acggcagccg ggtcaaaaaa gcgcagcaag aagccgcagc 1456081 ctttttggaa ggatgcaagg cccacatctc tgtgccagta caagaaatca gctttttaga 1456141 gcttcaggag ccgacaattg agacaggatt tgaagcatgt gtgaagcaag gtgccactca 1456201 tatcgcagtg gtgcctctgc ttcttttaac agctgcgcat gcaaaacatg atattccgga 1456261 agaaattgtc cgtgttgcat ctcgatatcc atcagtccgt atttcatacg gaaagccgat 1456321 cgggattgac gaagaagtag tcaaggctgt atatcaccga atgaaagaca taggtgttcc 1456381 gtatgaaaat gccagagtgg tgctcatcgg aaggggaagt tcagatccag acgtcaaaag 1456441 agacgtaacc ggaattgcta atcttcttca ggaaatggtt ccagtgaagg aagtcattcc 1456501 gtgctttttg acagcatgcg gccctaatta caaagaggtt ttttcagaac ttgaaaaaga 1456561 tgacggcata acaaccttta tcgttccata tttgcttttt acgggtatgc tgatgaatga 1456621 aatcgaacga gaggttcaga aattaaaagc ccataatccg aacgtctacc tctcttccta 1456681 tatcggtttt catcctcatg tgaaaaacgc atttttgaac cgtgtgagag aaactgcggc 1456741 aaattctgag ggacaatttg attttgatgg aggttcatat gcttccgctg cacattagcc 1456801 tggaaaagaa gaaggttgtg attgcggggg gcggaagcat cgctctcaga aggctgaaaa 1456861 cggtgatttc tgagggagct gatataacgc ttgtcagtcc ggatgtggaa ccggaaatca 1456921 agcaaatggc agaagagcgg cgtatcaaat gggaaaaacg gacaattgaa aaagaagatt 1456981 atctcaatgc tttcttcatt attgctgcga cggataatgc ggcagtgaac aaagaaattg 1457041 cccaatccgc ttcgcctttt cagcttgtca attgtgtcag tgacgctgag cttggcaatg 1457101 tatatatgcc gaaaatcgta aaaagagggc atgtcactgt gtctgtttct acaagcggag 1457161 ccagtccaaa gcacacgaaa gagcttgctg aaaacgtgga taagctgatt gacggcgatt 1457221 ttgttgctga agtgaacagg ctttatcaga tgagaagaaa gaaataagcc agagcataca 1457281 aatgctctgg cttttcttta tgcggctcag ctttttttga gcttgatgac agtatcagca 1457341 tcaggcgtga caaagacggt atgctggctg tcataagtga cgaaaccggg tttcgcgccg 1457401 tttggttttt tgacatgcct gatttttgta taatctacag gcactgaact tgaatcttta 1457461 gcttttgaaa aataagctgc aattgtcgcg gcttccatga ttgtttgctc atcaggttcg 1457521 ctgcttctga tcacaacgtg ggagccggga atgtccttcg tgtgaagcca gatatcgtct 1457581 ctggccgcca ctcttgtcgt taaatattca ttttgacgat tgttcttacc cactaaaatt 1457641 gtcagccctg aggtggattc atatgtttct aacaccggat tgtgcggttt ttgctttttc 1457701 tggccttttt gctgcttagg gcgtaaatat ttgccctcaa caagctcttc cctgatttcg 1457761 ctgatatccc ggggagaagc ggacgaaagc tgctgaatca gctgatcaaa atattcgatc 1457821 tcttcctgtg ccagcctgat ttgctcctcg acaactgcga ccgaattttt cgctttctga 1457881 tacttcgtga aataggcctg tgcgttttca gaaggcgttt tgttcgggtt taaaggaatc 1457941 gtgattgtcg ggctttcttc atcataataa ttgatgacct cagcctgttt atcacctttt 1458001 ttcagcatat ataaattagc ggttaaaagc tctccgtaaa gctgaaattc cttcgcgttt 1458061 tccgaatact ccagggtttt ctctaatttt ttgattttgt tggcattctt cttccgttcg 1458121 ttcacaacaa aacgctcaag atcctgagcc tgttgcttaa cccggtctcg ttcagctttt 1458181 ccgaaataaa aacggtcgag cagttcgctt aatgaatcaa aacggcgcgc ttcgcccttt 1458241 agatgagtca gctccagcag ataaaaatat tcctttccgt ttacagtcgt aatgttggga 1458301 atgaaacggt gctctttcac ttcggcaaac agtgccagca acgcttttgg cagtgtgact 1458361 ttgttggcaa ggcctgctct gtgaaccgct tctttggcga aaagcggaga cacgcctgaa 1458421 aagtggtcga caatttgttt atcaagcctt ccttcttgaa agctgaggtg acgcaaaata 1458481 tcatcttctg acgcctcaag aggcgatatt ttgtcctgag caggcggaag cttataatct 1458541 tggccgggca gtactgtacg gtagctgttc attgacggtg ataaatgctt aagtccgtcg 1458601 ataatcacat tttctgctgc gtcagtcaaa atgatattgc tgtggcggcc cataatttct 1458661 acataaagct ttcgtacggt ttcatcgcca atttcgtttc ggcttttgat atgaaaaatc 1458721 ataatgcggt ctaagcccgc ttgttcaatt ttctcaatga atccgccttc gatatgcttt 1458781 ctcagcaaca tgcaaaacat tggcggttcg cttggatttt cataagcttg tgccgtgata 1458841 tgcacccgtg aatagctcgg atgtgccgat aataatagtt tttggttttt tcccttggca 1458901 cggatgtgga aaatcacatc gtgcttatat ggctgatgga tttttgtaat tcgtccgccc 1458961 attattttct cgttaagttc gtgtgtcatt ccgtatgtaa acatgccatc aaacgacata 1459021 tgcaatacac cctctcattc ttcctgcatt cgataattat agcatgaaat gggacgagtc 1459081 agaataagca tgcttataga gtgatatctc tataagagag caggggagtg gacgagcgga 1459141 atgaagtttc atgaaatggg acaaacagat ttactagagg caaccaatac gtccatgaaa 1459201 caaggattaa cagaaaaaga ggtaaaaaaa cgccttgaca agcatggacc aaacgagctg 1459261 caagaaggga aaaaaacttc agcgcttctc ttgtttttcg cgcagttcaa agattttatg 1459321 gtgcttgtgc ttctggcggc aacgttaatc tcaggatttc ttggtgaata tgtagatgcg 1459381 gttgcgatta ttgcgattgt gtttgtgaat ggcatactcg gtttctttca agaaaggcgt 1459441 gctgagcaat ctcttcaggc tttaaaagag ctttcaacac cgcacgtcat ggcactcagg 1459501 gaaggaagct ggacaaagat tccttctaag gaactggtgc cgggtgatat tgtgaaattt 1459561 acgagcgggg acagaattgg cgcagacgtt cgaattgttg aagcgagaag ccttgaaata 1459621 gaagaatcag cgctaaccgg ggaatcaatc ccggttgtga agcatgctga taaattgaaa 1459681 aaaccggatg tttcactcgg cgatattacc aatatggcat ttatgggtac gattgtgacc 1459741 cgcggcagcg gtgtcggggt tgtcgtcggg acaggaatga atacggctat ggggaaaatt 1459801 gccgacatgc ttgaatcggc agggacattg tcaaccccgc tgcaaagaag actggagcag 1459861 ctcgggaaga ttttgattgt tgttgcattg cttctgaccg tacttgtcgt tgctgtcggt 1459921 gttattcagg gtcatgatct gtacagtatg tttttagcag gtgtctcgtt agcggtagcc 1459981 gctattccgg aggggctgcc ggcgattgtg acagtggcgc tttcgcttgg tgtacagagg 1460041 atgattaaac aaaaatccat tgttagaaag cttcctgctg ttgaaacgct tgggtgtgcg 1460101 tctatcattt gctcagataa aacagggaca atgacccaaa acaaaatgac agtgacgcat 1460161 gtctggtccg gagggaaaac atggagagtg gcaggggccg gctatgaacc gaaaggaagc 1460221 ttcacactaa acgaaaaaga gatcagtgtc aatgaacata agccgcttca gcagatgctt 1460281 ctgttcggag cgctttgtaa caactccaat attgagaaaa gagacggcga atatgtgctt 1460341 gacggagatc cgacagaggg agcgctgctc accgcggcaa gaaaaggcgg tttttcaaag 1460401 gagtttgttg aatctaatta cagagtgatt gaagaatttc cgtttgattc cgcacggaaa 1460461 atgatgactg tcatcgtaga gaatcaagac agaaagcgct atatcattac aaaaggtgcg 1460521 ccggatgtac tcatgcagcg atcttcccgt atttattatg atggctcagc ggctcttttt 1460581 tcaaatgaaa gaaaagcaga aacagaggcg gtattaagac atttggcatc acaggcgctc 1460641 agaacgatag cggtcgccta caggccgata aaagcaggcg aaacaccgtc aatggagcag 1460701 gcggaaaaag atctgaccat gcttggcctt tcaggtatca ttgatccccc gcggccggaa 1460761 gtcagacagg cgattaaaga atgccgtgaa gcgggaatta agaccgtcat gattacaggt 1460821 gatcatgtag aaaccgctaa agcgatagcg aaagacttgc gcctccttcc gaaaagcggc 1460881 aaaatcatgg acggcaagat gctgaatgaa ctttctcaag aagagctttc tcatgtggtg 1460941 gaggatgtgt atgtatttgc ccgcgtttcc cctgaacata aactaaaaat cgtaaaagcc 1461001 tatcaggaga acgggcatat tgtggcgatg acgggagacg gcgtcaatga tgctcctgcc 1461061 attaaacagg ctgatatcgg cgtctctatg ggcattaccg ggacagatgt ggccaaagaa 1461121 gcatcatctc ttgttctcgt ggatgataat tttgcgacga ttaaatcagc gataaaagaa 1461181 ggcaggaaca tctacgaaaa tatcaggaag tttatcagat acctgttggc gtctaacgtc 1461241 ggagaaatcc ttgtcatgct gtttgcgatg ctgcttgccc ttcctttacc gctggttccg 1461301 attcagattt tgtgggtcaa cttggtgacg gacggattgc cggcaatggc gctcggcatg 1461361 gatcagccgg aaggagacgt catgaagcgc aagccccgtc atccgaaaga aggggtattt 1461421 gcccgcaagc taggatggaa ggtcgtttcc agaggatttt taatcggagt tgccactatt 1461481 ttagcgttta tcattgtgta ccaccgcaat ccggaaaact tggcttatgc ccagacgatc 1461541 gcgtttgcca cattggtgct cgctcagctt attcacgtgt ttgactgccg cagcgaaact 1461601 tctgttttct ctagaaatcc gtttcaaaac ctgtatttaa tcggcgcggt attgtcatcc 1461661 attttgctga tgcttgtagt aatctactat ccgccgcttc agccgatttt ccatactgta 1461721 gccatcacgc cgggggactg gatgctcgtc atcggtatgt ccgccatccc tacttttttg 1461781 ctggcggggt cacttttaac aagaaaaaaa taaattcata tgatataatc ttaggggtaa 1461841 tagcgtgtct attgcccttt tattatgaga acagggaaga attgggtgtt ttaaaatgat 1461901 acgaagtatg acaggcttcg gcagtgcaag caaaacacaa gacgatctct ctgtaagcgt 1461961 tgaacttaaa tctgtgaact acagatttaa agaagtgaac gctcgtttgc caaggccttt 1462021 gctatatttt gaagataagc tgaaacagac cattctgcag catattcagc gcggaagaat 1462081 tgagcttttc gtatccgttg acagcgatat gcttgttgag aaaaggcttg aaattgattg 1462141 gccgctgctc gatgagtttg tcgcagccgc gagagatatg aagaagcggt atcaattgtc 1462201 tgcagagccc gatgtaatgg atttctttaa gcttgatcat gtcgtccagg ttcatgaaga 1462261 acagacgcaa aatgacaagc tggaggcgtt gatcatcgat gctgcagaag aagcggtaaa 1462321 aggtctctgt gaaatgcgtg aaaaagaggg gctgctctta gcgaaagact gcctgatgca 1462381 tattgatcag cttgaagagc tggtgagaga aactgaattg ctggctgcag atgtcgtatc 1462441 tcgttaccgg gaacggctgt atgccagaat caaagaatgg actgaagacg tattagacga 1462501 gagccggctt gtaacagaat gcgctatttt tgcagaccgc tctgatatca ctgaagagat 1462561 tacaaggctg aagagccact tcgcccagtt tcgtgatata ttagctagtg gcggagctgt 1462621 cgggcgcaaa ctcgactttc ttgttcagga gctcaatcgg gaagcaaata cgatcggctc 1462681 aaaagcaaat gatcatcaga tcacaaagct tgtcgttgaa atgaaaagtt ctattgaaaa 1462741 aataaaagaa caagtgcaaa atatagaata gtgactgtgc gtattgttta cagacggtct 1462801 tactaggcta aactagagac gtctatttta cagggggaac gtagaagatg acgattaaac 1462861 tgattaatat cggatttggc aatatcatct ccgccaatcg gatgatttcg attgtcagcc 1462921 cggagtctgc gccaatcaaa cggatgattc aggatgcaag agaccgcgga atgctaattg 1462981 acgctacata cggacgaaga acccgtgcag ttgtcgtcat ggatagtgat cacattatct 1463041 tatctgccgt ccagcctgag acagttgcac acagactttc tgttaaagaa gaaattatgg 1463101 atgaagggca ggggtaattg ccgcatgaaa gaaagagggt tattaatcgt tctctcaggt 1463161 ccctcaggag ttggtaaagg aacggttcga caagcgatct tttcgcagga agacacaaaa 1463221 tttgaatatt cgatttcagt aaccacaaga agtccaagag agggcgaagt gaacggagtc 1463281 gattattttt tcaaaacaag agacgaattc gagcaaatga ttgcggacaa caagctgctt 1463341 gaatgggcag agtatgtcgg caattattac ggcacgccag tcgattatgt tgaacagacg 1463401 cttcaagatg gaaaagacgt ctttttagaa attgaagttc aaggggctct tcaagtgaga 1463461 aatgctttcc cggaaggcct gtttattttc cttgcgcctc caagcctttc tgaactgaaa 1463521 aacagaatcg tgacacgagg aacagaaaca gacgctctga ttgaaaatcg aatgaaagcc 1463581 gcaaaagctg agatcgaaat gatggatgct tatgactatg tcgttgaaaa cgataatgtc 1463641 gaaacggctt gcgataaaat caaagcaatc gttcttgctg aacatttgaa gcgtgaacgc 1463701 gttgcaccaa gatataagaa aatgctggag gttgaataat caatgttaga tccgtcaatt 1463761 gattctttaa tgaataaatt agattcaaaa tatacgctgg tgactgtttc tgcgagacgt 1463821 gcccgtgaaa tgcaaatcaa aaaagaccaa atgattgaac atacgatttc acacaaatat 1463881 gtaggcaaag ctttagaaga aattgatgca ggcctgcttt cgtttgaaaa ggaagaccgc 1463941 gaatagtagc acaagtagca acctatatca tgtaggttgt tatttttttc cgtgcggttt 1464001 tgtaaagtgc agagggggag aattcattgc ttaacaatcg aaatgtgtta ctttgcgtga 1464061 gtggaggcat cgctgtttat aaagcctgtg cgttaacgag caagctggtt caggcaggag 1464121 caaatgtcaa agtgattatg actgaatccg cttgccgatt cgtttcaccg ctgacatttc 1464181 aggcattgag ccgccacgaa gtctatacag atacatttaa agaacaaaat ccaagcgtca 1464241 tttctcatat tgatgccgca gactgggccg acttgattat cgtagcgccg gctacggcta 1464301 atgtgattgg aaaactggca aacggcatcg ctgatgatat gctgacgaca acattgttgg 1464361 cagcaacggc tcccgtttgg atcgcgccgg caatgaacgt tcatatgtat gaccacccgg 1464421 cagtcaaacg aaacatttct gttctttatc aggacggtta ttgttttatt gagccaagtg 1464481 agggctattt agcatgcggt tacgtaggaa aaggcagatt ggaagagccg gaaaacatcg 1464541 taaagctggc cgaaaaacat tttgctgaag aaacatccgc tcctttagaa ggcaagcatg 1464601 tggtcattac agccggccca acgcgggaag cgattgatcc tgtccggttt tttaccaata 1464661 aatcgacggg caaaatgggc tacgcactgg cggaggctgc tgttcagctc ggcgcacggg 1464721 taatcttaat ttctgggcct gtttcacttg atcagcctaa aggccttgct gagtttatcc 1464781 ctgttcaatc ggctgcggat atgcgcgaag ctgtgctctc tgtgtatgac gcaagcgata 1464841 tagtcattaa aacagctgcg gtagccgatt ttacgccgaa aacagtattt gaccataaaa 1464901 tgaaaaaaca agacggcggc atgaccttag aactgaaaag aacagtcgat attttgaaag 1464961 aattgggcga gaaaaagaaa gagcagattt tggtcggatt tgccgccgaa acacaagaca 1465021 ttgaacacta tgcacgtaaa aagctcgccg ctaaaaacct tgatttgatt gtggcaaatg 1465081 atgtgaaagc aaatggggcc ggttttggtg ctgatacgaa tatcgtgaca atctttttca 1465141 aagacgggca taaacgcgaa ctcccgatta tgtctaagct cgatgtttct tttgaaatcc 1465201 ttcaggagat cgcagccctc tcaaaacaaa ccggagagcg ctcatgaatt ttgcagaagt 1465261 catcgttgat gtcagcacca aaaatataga caggcctttt gattataaaa tcccagacca 1465321 tctgaagggc atgatcaaaa cggggatgcg ggtcattgtt ccgtttggcc cccgtaagat 1465381 tcaagggttt gtgacagcag tcaaagaagc atctgaccta tcgggaaaat ctgtcaagga 1465441 agtagaggat ttattagatc ttacacctgt tctgacagag gagcttatga ttctgtcatc 1465501 atggctgtca gacaaaacgc tgtcttttaa aataacggcg cttcaagcaa tgctgcctgc 1465561 cgccttaaag gcgaaatatg aaaaagaatt aaaaattgca cacggagccg atcttccgcc 1465621 gcaagtggaa cggctgtttt ctgaaacaaa gacgctgctg tattcagata tacccgatca 1465681 tgagacgctg aaactgattc aaaggcatgt tcaaaaaggg gacattgacg tgacgtataa 1465741 agtcgcgcaa aaaaccaata aaaaaatggt caggcatatt caggcaaatg cgagtaaaga 1465801 agagcttgct aagcaggctg agggattgtc ccgccaagca gcaaaacagc aggcgattct 1465861 tcactttctc atctctgagc cggaaggtgt gaaaattcct gcggcggaat tgtgcaaaaa 1465921 aacggacacg agctctgcaa ccatcaaaac ccttatccaa aaagggcttt tgaaggaaag 1465981 ctatgaagag gtttacagag atccctatca ggacaaaatg ttcaaaaaaa cagagcccct 1466041 gccgctgaca gacgaacaga gggctgcctt cgagcccata cgcgagacat tggacagcga 1466101 tgagcataaa gtgttcctcc ttcacggcgt gacaggaagc ggaaaaaccg aaatttatct 1466161 gcaatcaatt gaaaaagtac tggcgaaagg aaaagaagcc atcgtcctcg taccggaaat 1466221 atcgctgacg ccgcaaatgg tcaaccgctt caagggccgc ttcggctccc aggtggcagt 1466281 catgcacagc ggtttatcca caggagaaaa atatgacgag tggcgtaaaa tccaccggaa 1466341 ggaagtacgg cttgtcgtcg gtgccagatc cgccattttt gctccgtttg aaaatctcgg 1466401 aatgataatc atcgatgaag agcacgagtc ttcctataaa caggaagaaa tgccgcgcta 1466461 tcatgcgaaa gaggtggcaa tcaagcgggc tgagcatcac agctgcccgg ttgtattagg 1466521 gagtgctacg ccgacattag aatcatatgc tagagcgcaa aagggcgtat acgagcttct 1466581 ttcactgaag caccgtgtta accatcgggt gatgcccgag gtttcgcttg tcgatatgag 1466641 agaggagctt agaaacggca atcgctcgat gttttcagtt gaattgatgg aaaagcttga 1466701 agaaacgatt gccaagggtg agcaggcggt gctgttttta aataagaggg gctactcttc 1466761 ctttgtgatg tgcagggatt gcggctatgt cccgcaatgc ccgcactgcg acatttccat 1466821 gacgtatcat cgttacggcc aaaggctgaa atgccattat tgcggacatg aagagcctgt 1466881 tccgcacact tgtcctgaat gcgcaagcga gcatatccgc tttttcggaa cgggaacaca 1466941 gcgagtggag gaagagctga caaaagtgct gccaagtgcg agagtgattc ggatggatgt 1467001 tgacacgaca tcacggaaag gcgcccatga aaaattactg tcagctttcg gagaaggaaa 1467061 agcggatatt cttctcggaa cgcaaatgat cgcgaaaggg cttgattttc cgaatgtcac 1467121 gcttgtcgga gtgttaagtg ctgatacaac acttcatatt cctgatttca gatcggctga 1467181 aaaaacattt cagctgttaa cgcaagtcag cggccgggca ggcaggcatg aaaagcccgg 1467241 ccatgtcatc attcaaacgt atacaccgtc tcattacagt atccagctga cgaaaacaca 1467301 cgattatgaa acgttctatc agcatgaaat ggcgcacagg agagagcaat cctatccgcc 1467361 atactactat ttggctcttg tgactgtttc tcatgaggaa gtggcgaaag cagcggttac 1467421 agctgaaaaa atcgctcatt ttttgaaagc aaactgcgga gctgacacga aaattctcgg 1467481 accaagcgcg tcgccgatag ccaggatcaa agatagatat cgctatcaat gcgtgataaa 1467541 atacaaacag gaaacccagt tatccgcttt attgaagaag atactggaac attataaacg 1467601 cgaaattgaa caaaaacatg taatgatttc aattgatatg aatccttata tgatgatgta 1467661 agatctcacg tcttggaggg taacaaattg gcagtaaaaa aggtcgtcac acatcctgcg 1467721 gaggttttgg aaacacctgc ggaaaccgtg actgtttttg ataaaaagct aaaaaaactg 1467781 cttgatgata tgtacgacac catgcttgaa atggatggtg tcggactggc agcgccgcaa 1467841 atcggcattt taaaaagagc ggccgtcgta gaaatcgggg atgacagagg gagaattgat 1467901 ctcgttaatc ctgaaatttt agaaaaaagc ggcgagcaaa ccggaattga aggatgcttg 1467961 agctttccta acgtctatgg tgatgtcaca cgtgccgatt atgtcaaagt gcgtgcgttt 1468021 aaccgtcagg gaaaaccgtt cattctggaa gcgcgaggct ttttagcaag agccgtgcag 1468081 catgaaatgg accacttaga cggtgtgctg tttacatcta aaataagtaa atactataca 1468141 gaagatgaac tagcggatat ggaaggatga tttgatgacg agaatcgtat ttatgggaac 1468201 gccggatttt tcagttcctg ttttaagaac cctgatagag gacggatatg aagtagtggg 1468261 ggtcgtcaca cagccggacc gtccgaaggg cagaaaaaaa gtactgacac ctcctccggt 1468321 aaaggaagag gcattgcgcc acggcatccc ggttcttcag ccggaaaaag tcagattgac 1468381 agaagaaatt gaaaaagtgc tggcattaaa gcctgacctg attgtaacgg cggcattcgg 1468441 acaaattttg cctaaagagc ttctcgacag tccaaaatac ggctgcatta acgttcacgc 1468501 atcccttttg ccggaactgc gcggcggtgc tccgatccat tattccattc tgcagggaaa 1468561 gaagaaaacc gggattacca ttatgtatat ggtagaaaaa ttggatgcgg gcgatatgat 1468621 ctcaaaagtg gaagtggaca ttgaagaaac cgacaatgtc ggaacactgc acgataaatt 1468681 aagcgttgct ggcgcgaagc tattgtctga aacggttcca aacgttattg ccggcagcat 1468741 atcacctgaa aagcaggatg aagagaaagc gacgtacgcg cctaacatta aaagagagca 1468801 agagctgctc gactggtcca gaacgggcga agagctttac aaccagatcc gcggcttaaa 1468861 tccatggcct gttgcttata cgactctaaa cggacaaaac ttgaaaatat gggcgtcgaa 1468921 aaaaatagcg gcaccaacaa cagctgagcc cggcacagtc gttgcagttg aaaaggaagg 1468981 aattatcgtt gccacaggta acgagacggc tctgttatta accgaactcc agccggcagg 1469041 caaaaaacga atgaaaggcg aagactttgt gcgaggcgct catgttgaag ccggtgatgt 1469101 gttaggagta aacaatgaaa aaaactagtg ttcgtgacat cgcccttgag gcgctgatca 1469161 aattagaaca aaaccaggca tacagcaacc tgctgctgaa atcggtcatt aaatcaaatg 1469221 aactgagtga tcagaacaga gggcttttga ctgaacttgt ctatggtaca ttacaaaata 1469281 agatcgcgct tgattatatg cttaaaccgt ttatcaataa gcctcaaaag gtaaagccgt 1469341 gggtgattca gcttcttcgc ctatccttat atcaaatgga gtatttggag aagattccag 1469401 acagggcagc cattcatgaa gcggttgaga ttgctaaaat ccgcggacac aaaggcattg 1469461 cttcatttgt caacggcgtg ctccgttcta ttcagcgcga aggtgttcca tcctttgacg 1469521 cgatcgaaga tcctgtccgc cggctggcga cagaaacaag ccatccggaa tggcttgtga 1469581 aagagtgggc ggatgcgtat ggatttgaag ctgcggaaaa gatttgccgc atccatctca 1469641 ttccgccgaa acagacgctg cgtgtcaatc aaatgaaagc agacagagct gagctgcttg 1469701 accaaatggc tgctgaggga atcgaagttg aaaaaggcga cctcgctgaa gatgctgtga 1469761 agctcttaaa gggaacaatt gccggaactc atttcttcca aaacggcgaa gtttctatcc 1469821 aggatgagag ctccatgctc gtcgcccgcg cccttgatcc taagtcagat gaaacagtgc 1469881 ttgacgcgtg tgcggcgcct ggcggaaagt cggctcatat cgcagaatta atgaagaaca 1469941 aggggagcgt tacgtcgctt gatcttcaca aacataaagt gaagctgatc aaagaagcgg 1470001 cagatcggct tggcctgaca atcattcatg cggaaacaat ggatgctaga aaagcggggg 1470061 aaacgtttga aaacgaacag tttgaccgaa tattggtcga tgccccgtgc tcaggtttcg 1470121 gtgttatcag aagaaagccg gacatgaaat acacgaaaaa acctgacgac agcgcccgtc 1470181 tagctgaaat ccagctgtcg atcttgaggg aaatcgcacc attagtaaaa aaaggtggca 1470241 ctcttgtcta cagtacgtgt acaatggacc ggacagaaaa tgatgaagta atacatgcgt 1470301 ttatacaaga acatcctgat tttgaacccg atttgtctct tgaaaagcgg ctgcctgaaa 1470361 aggtgagacc ctttgttcgg gatggaaggc ttcaaatcct tcctcattat ttcggaacag 1470421 atggtttctt tatttgcagc atgagaaaga agggataagc aatggcagaa cttaataaaa 1470481 caaaagtaag aaaagaattg cggacagagc gtccgtctat ttattctttt gaattagatg 1470541 aaatcaaaca atggctgaca gacaatggag agaaaccgtt ccgtgcagcc cagatctttg 1470601 aatggctata tgaaaaacgc gtatcttctt ttgaagatat gacaaacctc tcaaaggatc 1470661 tgcgtgagaa attaaacact cgctttgtgt taacaacgct gaaaacggct gttaaacaaa 1470721 cctctcaaga cggtacgatg aagtttttgt ttgagcttca tgacggttat accatcgaaa 1470781 ccgttttaat gagacacgag tatggcaatt ctgtatgtgt aacgacacaa gtcggctgcc 1470841 gtattggctg cacattctgc gcgtcaacgc ttggaggctt aaaacgaaac cttgaagcag 1470901 gggaaattgt cgctcaagta gtcaaagtgc aaaaagctct tgatgaaacg gatgaacgcg 1470961 tcagctctgt cgtgatcatg ggaatcggcg aaccttttga taactttaac gaaatgctcg 1471021 ctttcttgaa aatcattaac catgacaagg gcctgaatat cggtgctcgc catattacgg 1471081 tctctacgag tggaatcatc ccgaaaattt acgaatttgc tgatcagcaa atgcagatta 1471141 actttgcaat ttctctgcac gcgccgaaca cagaaatcag aagccgtttg atgccgatta 1471201 acagagcata taaactgcct gatctaatgg aagccgttaa atattatatt aataaaacag 1471261 gacgccgtat cagctttgaa tacgggctgt tcggaggcgt aaacgaccag gtggaacacg 1471321 ccgaagagct tgccgacttg ctggaaggag tcaaatgcca cgtgaacttg attccggtaa 1471381 actacgtgcc tgaacgggac tatgtgcgca caccgcgtga tcagattttt gcttttgaaa 1471441 aaacgctgaa atcccgcgga gtaaatgtca caatccgaag agagcaagga catgacattg 1471501 acgcagcctg cggtcagctt cgcgcgaagg agcgtcaaga cgagacgagg tgatgagggt 1471561 tgttaacagc cttaaaaaca gatacaggaa aaatccgcca gcataatgaa gatgatgcgg 1471621 ggatattcaa ggggaaagat gaatttatat tagcggttgt cgctgatggc atgggcggcc 1471681 atcttgctgg agatgttgcg agcaagatgg ctgtgaaagc catgggggag aaatggaatg 1471741 aagcagagac gattccaact gcgccctcgg aatgtgaaaa atggctcatt gaacagattc 1471801 tatcggtaaa cagcaaaata tacgatcacg ctcaagccca cgaagaatgc caaggcatgg 1471861 ggacgacgat tgtatgtgca ctttttacgg ggaaaacggt ttctgttgcc catatcggag 1471921 acagcagatg ctatttgctt caggacgatg atttcgttca agtgacagaa gaccattcgc 1471981 ttgtaaatga actggttcgc actggagaga tttccagaga agacgctgaa catcatccgc 1472041 gaaaaaatgt gttgacgaag gcgcttggaa cagaccagtt agtcagtatt gacacccgtt 1472101 cctttgatat agaacccgga gacaaactgc ttctatgttc tgacggactg acaaataaag 1472161 tggaaggcac tgagttaaaa gacatcctgc aaagcgattc agctcctcag gaaaaagtaa 1472221 acctgcttgt ggacaaagcc aatcagaatg gcggagaaga caacattaca gcagttttgc 1472281 ttgagcttgc tttacaagtt gaagagggtg aagatcagtg ctaatcggca agcggatcag 1472341 cgggcgttac caaattctcc gcgtcatagg cggcggggga atggccaacg tgtatttagc 1472401 tgaggatatc attctagacc gtgaagtcgc aattaaaatc ctgcggtttg actatgcaaa 1472461 tgacaatgaa tttatcagac gtttccgcag agaagcccaa tccgcatcaa gcctcgatca 1472521 cccgaatatt gtcagcattt atgatttggg cgaggaagat gatatttatt atattgtcat 1472581 ggaatacgtt gaaggcatga cgcttaaaga atacataaca gcaaatgggc cgcttcaccc 1472641 taaagaagcg ctgaacatca tggagcaaat tgtctcagcc atcgctcatg cccatcaaaa 1472701 ccagattgtt cacagagaca tcaagccgca taacattttg attgatcata tgggaaatat 1472761 caaagtaacg gattttggaa ttgcgacggc actaagttcg accacaatca cccataccaa 1472821 ttcagttctg ggctcggtcc attacttatc acctgaacag gcccggggcg gcttagccac 1472881 aaaaaaatcg gatatttatg cgcttggaat cgttctattt gagcttttaa ccggccgtat 1472941 tccgtttgat ggagagtcag cagtcagcat cgccttgaag catcttcaag cggaaactcc 1473001 ttcggcaaaa aggtggaatc catcggtccc ccaaagcgtt gaaaacatca tactcaaggc 1473061 aactgccaaa gatccttttc atcgctacga aacggctgaa gacatggaag cagacataaa 1473121 aacagctttt gatgccgaca gactcaatga aaagagattt acgattcaag aagatgaaga 1473181 aatgacaaaa gcgataccta tcattaaaga tgaagaactt gctaaagctg ctggcgaaaa 1473241 agaagctgaa gtgacaaccg cacaagaaaa caaaacaaag aagaacggca aaagaaaaaa 1473301 gtggccgtgg gttttgctca cgatatgcct cgtttttatc acagctggaa ttcttgctgt 1473361 cactgttttt ccgtcgcttt tcatgcctaa ggatgtcaaa atacctgatg tctccggaat 1473421 ggaatacgaa aaagccgcag ggctcttgga aaaagaaggt ttacaggttg attccgaggt 1473481 gttggaaatc tcagatgaaa aaattgaaga gggcctgatg gtaaaaacgg atcctaaagc 1473541 ggataccaca gtcaaagaag gcgccacggt caccctttat aagagcaccg gaaaagcaaa 1473601 aacggagatc ggtgatgtga caggccaaac ggtcgaccaa gcaaaaaaag cgttgaagga 1473661 ccaagggttt aatcatgtaa cagtaaatga agtgaatgac gagaaaaatg cgggcactgt 1473721 cattgaccaa aatccttcag cagggactga gctggtcccg agtgaagatc aagtcaaact 1473781 tacagtcagt atcggacccg aagacattac gcttagagac ttgaaaacct acagtaaaga 1473841 agcagcgtct ggatatctgg aagacaacgg attgaagctt gtagaaaaag aagcatactc 1473901 agatgatgtt ccagaaggac aggttgtcaa acaaaaacca gcagcaggta cggcagtaaa 1473961 gccgggaaac gaagttgaag tgacattctc tctcggacca gagaaaaaac ctgcgaaaac 1474021 agtgaaagaa aaggtcaaga tcccctacga accagaaaat gaaggggacg agcttcaagt 1474081 gcaaatcgcg gttgacgatg cggatcacag catctctgac acttacgaag aatttaagat 1474141 aaaagagccg actgaacgaa cgatcgaact aaagattgaa ccaggccaaa aagggtacta 1474201 tcaagtaatg gtaaacaata aagttgtcag ctacaaaacc attgagtatc cgaaagatga 1474261 ataacaagga gggaaaatat gcctgagggc aaaattatta aggcgctaag cggcttttac 1474321 tatgtactgg atgaatcaga ggattcagat aaagtaatac aatgcagagg aagaggcatt 1474381 ttcagaaaaa acaaaattac ccctcttgtc ggtgattacg ttgtgtatca agctgaaaat 1474441 gacaaagaag gatatctaat ggaaattaaa gaaagaacca acgagcttat caggccgcca 1474501 atttgcaacg ttgatcaagc ggtccttgtt ttctcagcgg ttcagccttc tttcagcacg 1474561 gcattgctcg accgcttcct ggttctcgtt gaggccaatg atattcagcc gattatatgc 1474621 attactaaaa tggatctgat tgaagatcaa gatacagaag atacgataca agcctatgca 1474681 gaagactatc ggaatattgg ttatgacgta taccttacct cctctaagga ccaagatagt 1474741 ttagcggaca tcatcccgca ttttcaggat aaaacaacgg tatttgccgg tcagtccggt 1474801 gttgggaaat cctcgcttct caacgcgatc agtccggagc tcggattaag aacaaacgag 1474861 atttccgagc atttgggccg cgggaaacac acaacccgcc acgtggagct gattcacacg 1474921 tccggaggtt tggttgcaga tacaccggga ttcagctcgc ttgaatttac agacattgag 1474981 gaagaagagc tgggctatac cttccctgat atcagagaaa aaagctcttc atgcaaattt 1475041 agaggctgtt tacatctgaa agagccgaaa tgtgcggtga aacaagctgt tgaagacggg 1475101 gaattaaagc agtatcgcta tgaccattat gttgaattta tgacggagat taaagacaga 1475161 aagccgaggt attagcataa tgataaaggt tgcaccatct attctttccg ctgattttgc 1475221 cgctttaggc aatgagatta aagatgtaga aaaaggcgga gccgattgta ttcatattga 1475281 tgttatggac ggccattttg tcccgaatat cacaatcggt ccgctgattg tagaagcggt 1475341 ccggccggta acggatctgc cgcttgatgt ccatttaatg atagaagagc cggatcgtta 1475401 tatcccggct tttgcgaaag caggcgcaga tatcctgtct gtgcatgctg aggcatgtcc 1475461 gcacctgcac cgtaccatcc agctcattaa agagcaagga gtgaaggccg gagtagttct 1475521 aaacccgcat acccctgtac aagtcatcga acatgttttc gacgatcttg atcttgttct 1475581 tttaatgacg gtgaacccgg gcttcggcgg gcagaaattt attcattcag tccttcctaa 1475641 aataaaagag gttaagcgaa tggcggatga aaaaggaaaa aaagatctgt taattgaagt 1475701 agacggcggc gtcaacaaag aaaccgctcc gctcgtcatt gaagcgggcg caaatttact 1475761 cgttgccggt tcagctgttt atggccagtc tgaccgcaaa aaagcaattt ctgaaatcag 1475821 aggaagtaaa taagcagctt tagaaaagag ctgggcatac aatagcctaa gctctttttc 1475881 ctgtatgcag agaaaggaat cagagatgaa aacaattaat atcgttgcgg gaggcccgaa 1475941 aaatctcatt cccgatctaa ccggctatac ggatgaacac acgctttgga tcggtgttga 1476001 caaaggcacc gtcactctct tagatgccgg gatcattcct gttgaagcct tcggagattt 1476061 tgacagcata acggagcaag aacgccggcg aatagaaaaa gccgctcccg cccttcatgt 1476121 gtatcaagca gaaaaagatc aaacagattt agacctcgcc cttgattggg cgctggaaaa 1476181 gcagccggat attattcaga ttttcggcat tacaggcggc agagctgatc attttttagg 1476241 aaacattcag cttctgtata aaggtgtaaa aacgaacata aaaattaggc tgatagacaa 1476301 acaaaatcat attcaaatgt tccctcctgg tgaatatgat attgagaagg atgaaaataa 1476361 gcgatatatc tccttcatac cgttttccga agacatacat gagctgaccc tgaccggttt 1476421 taaatatcct ctaaataatt gtcatattac gctcggttca acactatgta ttagtaacga 1476481 actcattcat tcacgaggta ctttttcgtt tgcaaaaggc atattaataa tgataagaag 1476541 cacggattaa gcatgtgctt tcattcaatt gctgaaaaca atgaacaagg cggttacggg 1476601 acgttatagg aggggacaaa aatgaaattt tacaccatta aattgccgaa gtttttagga 1476661 ggaattgtcc gggcgatgct gggctcattt agaaaagatt aatgcccagg ggttcaaagc 1476721 cctctttcac cacataaaaa cgcctgccac atatcggggc aggcgttcat tttgttatac 1476781 acgctcaact ttaccggatt tcaaagctcg agcagataca tatacttttt taggttttcc 1476841 gttcacaagg atacgaacct tttgaagatt cgcgccccaa gtgcgcttag aagcgttcat 1476901 tgcgtgagaa cggttattcc cagctgttgt ttttttacct gtgataacgc atttacgtgc 1476961 catttgtttc cctcctcact tgcacaaaac atctactttt taacattcat ataatcttag 1477021 atgctttcga tatggatact ttaaataatt taccacagct aaaaaacgtt tgcaactatt 1477081 gtttcatcat ctttcaagaa aattcacttg acatcttgcg gaaacagcag cgctatagta 1477141 tatgtagagg tacggccagc gattattgcc tggtcttttc ataatggaaa ccatatagta 1477201 gaatagctgt aactctatgc attcgaagga ggaactagtg tgtccattga attaagaacg 1477261 aagtacggac agattgatat atctaatgaa gtcatcgcga tggttgcagg aggcgcggcg 1477321 gttgactgtt acggcattgt cggcatggcc tctaaaaacc agattaaaga cggactgact 1477381 gaaatccttc ggaaagagaa tttcagcagg ggtgtccaag ttcgccaaga aggagaacag 1477441 atacatatcg acatgtatat cattgtcagc tacggcacga aaatttctga agtggcacat 1477501 aatgtccaaa caaaagtaaa gtacacagta aatcaaacca tcggactggc agtggattct 1477561 gtcaatattt atgtccaagg cgtacgagtg acgaacccgt agttaggagg agtaggattg 1477621 tctatcagaa cattagacgg cagaaccttt gccgagatga ttcttgcggg agcgcagaat 1477681 ctgtctcaaa acgccagtgc agttgatgca ctgaacgtgt tcccggtgcc ggacggtgat 1477741 acgggaacaa atatgaacct gtcgatgact tccggagcaa gagaagttga acaaatggat 1477801 acggatgata tcgggaaggt gggctccgcg ttatctaaag ggctgctcat gggagcacgc 1477861 ggaaattcag gagttatcct atcccaattg ttccgcggat ttagcaaaaa cattgaaacg 1477921 aaaaaagaaa ttaatgcact tgagtttgcc gctgcgctgc aagcaggtgt agacatggcg 1477981 tataaagctg tcatgaaacc tgtagagggc accattttaa cagttgcaaa agacgctgca 1478041 aaaaaagcaa tgatcttagc agaaaaagaa accgatatca ctgcgctgat gactgcagtg 1478101 acagaagaag cagaggcgtc tttaaaccgc acccctgaat tgctacctgt cctaaaggaa 1478161 gtaggagttg tcgatagcgg gggcaaaggc ctgctctgtg tgtatgaagg tttccttgct 1478221 tcattaaaag gtgaaactgt acctcagaaa gcagttcttc cgtcacttga cgacatggtc 1478281 agcgcagagc atcacaagag cgcgcaaagc atgatgaata ccgaagatat tgaatttgga 1478341 ttctgtaccg aagtgatggt taggcttgat cagacaaaaa gagagttcga cgaaggcacg 1478401 ttcaggcaag acctcagcca gttcggagat tctctgcttg tgattgcgga tgaatcgctg 1478461 gcgaaggttc atattcatgc tgaagagccg ggaaacgtgt taaactacgc ccagcattac 1478521 ggtgaattga tcaaaataaa aatagaaaat atgagagaac agcatacctc tatcatcagt 1478581 caagaaagca aacctgcaga caacgaaaca ccgccggcaa aacagccgta tggcattgtg 1478641 actgtagcga tgggagaagg aattgcagac ctatttaaaa gcattggcgc ttctgttgtg 1478701 attgaaggcg gccagaccat gaacccaagc actgaggata ttgttgatgc cgtgaagtct 1478761 gtaaatgcag atacggtatt tatcctgcct aacaactcca acattatcat ggctgctaac 1478821 caagcggcca gcgtagtgga tgaacaggtt tttgtcattc ctgctaaaac ggttccgcaa 1478881 gggatgtcag ctctgctggc ttttaacccg gatcaagaag ctgaagcgaa cgaggccaat 1478941 atgctaagcg ccattcagca agtaaaaagc ggacaggtga cgttctcagt cagagatact 1479001 catattgacg gtaaagacat taaaaaaggc gactttatgg gcattctgaa tggaacgatt 1479061 atcggcactt ctgaaaatca gctgtcagcc gcgaaaatgc tgctgtcaga aatgatcgga 1479121 gaagatgatg aaatcgtgac cattctatat ggtgaggatg cgtctcagga agaagctgag 1479181 cagcttgaag cgtttctcag tgaaaagtac gaggagattg aggttgagat ccacaatggg 1479241 aaacagcctc tgtattcgta tatagtttca gcagaataga agggcaattt gcccttctat 1479301 tcttatgtct gcttttaagt gcggcagcgc tgtaacgcgc ccgcttgcca ttttatatct 1479361 gatcaattag tctagaagca aagcgctaat aagctctggt tcataaggag gaatagcatg 1479421 aaatacagaa gcgtttttga tattatcggc ccggttatga tcggtccgtc cagctctcat 1479481 acagcgggag ctgctagaat cgggagagtg gccagaagtt tatttggcag agagcctgag 1479541 cgcatcattg tatcttttta cggctcgttt gcggaaacgt ataagggcca cggcacagat 1479601 gtcgcgatta tcggcggatt gcttgatttt gatacattcg atgaacggat taaaaccgct 1479661 atacaaattg cagaagctaa aggaattgat atagagtttc gggtagaaga cgcagtcccg 1479721 gtccacccga acacagcaaa aatcaccatt tctgatgaaa agggtgagct ggaactgacg 1479781 ggtatttcga ttggcggagg aaagattgaa atcacagaat tgaatggttt tgagctccgg 1479841 ctgtcaggaa atcatccggc catattagtt gttcataatg acaagtttgg cacaattgcc 1479901 ggtgttgcca atgttctggc gaaattttca atcaacgtag gacatatgga agtagcccgg 1479961 aaagatatcg gccagcttgc gctgatgaca atagaggtcg atcaaaatat tgacgaccac 1480021 attctcgacg agctgtcgaa gctgccgaat attattcaag tgacaaagat tgctgactag 1480081 cgaaaagggt caggaggagc cagttatgtt tcgtaatgta aaagaattaa ttgagattac 1480141 taaagaaaaa caaatattga tctctgatgt gatgatagct caagagatgg aagtaacaga 1480201 aaaaacaaaa gaggacattt ttcagcagat ggatcataac ctgtctgtta tggaagcggc 1480261 ggttcagaaa ggactcgagg gagttacgag ccaaacgggc ttaacaggcg gagatgccgt 1480321 taaattgcag gcctatattc gatcaggaaa aagcctgtct ggcccgctga ttttagatgc 1480381 tgtatcgaaa gccgttgcaa caaatgaagt aaatgcagcc atgggaacca tctgtgcgac 1480441 accgactgca ggttctgccg gtgtggtgcc cggtacgtta tttgctgtaa aagaaaagct 1480501 gaatccaaca agagaacaaa tgatccgctt tttgtttaca gccggggctt tcggatttgt 1480561 cgtggccaat aacgcaagca tttccggcgc cgccggagga tgtcaggcag aggttggatc 1480621 agcttcaggc atggcggctg cggctattgt tgaaatggca ggaggaacac ccgaacaaag 1480681 cgcggaagcc atggccatta cattaaaaaa tatgctaggc ctcgtgtgcg accctgttgc 1480741 agggcttgtt gaggtgcctt gcgtgaaacg gaatgcgatg ggcgcgtcaa atgcgatgat 1480801 tgctgctgat atggcattgg cgggcattac aagccgtatt ccatgtgatg aggttatcga 1480861 tgccatgtat aaaataggcc aaacgatgcc aactgcactt agagaaacag gccagggcgg 1480921 tttagcggca acaccgacag gaagagaatt agagaaaaaa attttcggag gagcgctagg 1480981 ttcacgtgaa acaacatcag caaactagta tagctaacat taagggtatt gggccggaaa 1481041 cagaaaaaac attgaatgaa ctcggtattt atgacatttc tgatcttctg aattatttcc 1481101 cttatcgcta tgatgactac gagctgaggg atttagaaga agtaaagcat gatgaaagag 1481161 tcacagtcga agggaaggtt cattcagagc cttctcttac ctattacgga aaaaaacgaa 1481221 acaggctgac attcaggctt ctggtcggcc actatttaat cacagccgta tgttttaacc 1481281 ggccttattt gaagaagaag ctttcgctcg gctctgtggt gacggtttca ggtaaatggg 1481341 acaagcaccg ccaaaccatc tctgttcagg agttgaaaaa cgggccgcat caagaagaca 1481401 aaagcattga accagtgtat tctgtgaaag aaaatgttac cgtcaaaatg atgaggcgct 1481461 ttattcagca ggcgctgacc caatatgcag actcacttcc tgatcctctt ccggaaaagc 1481521 taagaaaaag ctataaactg cctgactatt atcaagcgtt aaaagcaatg caccagcctg 1481581 aaacaaggga agcattaaag cttgccagac ggcggtttgt ttatgaagaa tttttgttgt 1481641 ttcagttgaa aatgcaggcg ttccgaaagg cggaaagaga gcagacacaa gggatacggc 1481701 agcgtttttc aaacgaagaa ctcatgagat ttatcaaaag cctcccgttt cccctcacaa 1481761 acgcccagtc acgcgttctt cgcgaaataa cagcagacat gtcttctcca tacagaatga 1481821 accgtcttct tcaaggggac gttggatcag gaaaaacggc agtcgccgcc attgcactgt 1481881 atgccgcgat cctatccgga taccaaggag cgctcatggt gccgacagaa attctggccg 1481941 agcagcatgc tgattcgctc gtttcgctat ttgaaaaatg ggacgtcagc gttgctcttt 1482001 tgacaagctc tgttaaagga aagcggcgaa aagaactgct tgagcgtctt gcggcgggtg 1482061 agattgatat tcttgtagga acccatgctt taatccaaga cgaggtggag tttaaggcgt 1482121 tgagtctcgt tattactgat gaacagcaca gatttggagt tgagcagcgc aaaaagcttc 1482181 ggaacaaagg gcaggatccc gatgttctct ttatgacagc cactccaatc ccaagaacat 1482241 tagcgatcac agtattcggt gaaatggatg tatctgtcat tgatgagatg ccggctggac 1482301 gaaagcgaat tgaaacctat tgggtaaaac atgacatgct tgatcgtatt ttggcatttg 1482361 tcgaaaaaga attaaagcaa ggcaggcagg cttatatcat ctgtccgctg attgaagaat 1482421 cagataagct tgatgtgcaa aacgccattg acgtgtacaa tatgctttct gatatttttc 1482481 ggggaaaatg gaatgtcggc cttatgcatg gaaagctgca ttccgatgaa aaagatcagg 1482541 tcatgagaga attcagcgca aatcactgtc aaattctcgt atcaaccact gttgtggagg 1482601 ttggcgtaaa tgttccgaat gcaacaatta tggtgattta tgacgccgac cgtttcggac 1482661 tatcacagct tcaccagctg cgcggccgtg ttggacgggg tgagcatcaa tctttctgta 1482721 ttctgatggc tgatccaaaa tcagaaacag ggaaagaacg gatgaggatc atgtcggaga 1482781 ccaatgacgg tttcgagctg tctgaaaagg atctggaact gagaggtccc ggtgatttct 1482841 tcgggaaaaa acaaagcgga atgccggaat ttaaagtggc ggacatggtt catgattaca 1482901 gagcgcttga aacggcaagg caggatgctg cgaatcttgt ggcttctgac gcgttctgga 1482961 aggagccgga atacgctgtg ttaagagatg aattgctgaa gagcggagta atggacgggg 1483021 aaaaattaag ctgagtatca gaagtttttg gtgttcagcc agaaacaatc gttgcattcc 1483081 aatctatgaa attatatact actattagta cctagtctta attgtccgga tggtgtttag 1483141 atatgagaag aaataagaga gaacgccagg aattacttca gcagacgatt caagcaaccc 1483201 cctttattac agatgaagaa ctagcgggta aattcggggt gagcatccag acgatacgtt 1483261 tggaccgctt agagctttcc atacctgaac tgagagaaag aattaagaac gtggcagaga 1483321 aaacacttga ggacgaagtg aagtccctgt cacttgatga agttatcgga gaaattattg 1483381 accttgagct ggatgatcag gcgatatcca ttttagaaat aaaacaggag cacgtgttca 1483441 gccggaatca gattgcgaga ggacaccatt tatttgcaca ggcgaattct ttggccgttg 1483501 cagtcattga tgacgagctg gcgctgactg caagtgcaga catccgcttt acaagacagg 1483561 taaagcaggg tgaacgtgtc gtagcaaaag cgaaagtgac ggctgtcgaa aaagaaaaag 1483621 gaagaacggt tgtcgaagtg aacagctacg ttggcgaaga aattgttttt tctggacgct 1483681 ttgacatgta tcgttcaaaa cattcataaa ggtggagcat gcatgagaat agctgtagat 1483741 gcaatgggag gagaccacgc tcccaaagct gttattgacg gagttataaa aggtatagag 1483801 gcatttgatg atctccatat cacacttgtc ggtgacaaaa caacgataga atcacattta 1483861 acaactacat cagatcgcat cacggtgctg cacgcagatg aagtgattga gcctacggat 1483921 gaaccggtcc gtgccgtgcg aagaaaaaag aactcatcta tggttcttat ggcgcaggag 1483981 gttgcggaaa acagagctga cgcctgcatt tcagcgggaa ataccggtgc attaatgaca 1484041 gccggtctct ttattgtcgg gagaattaaa ggaattgacc gtccggcgct tgctccgaca 1484101 cttccgactg tttcgggaga cggatttctt ctccttgatg tcggcgccaa tgtcgatgcc 1484161 aaaccggagc acctcgttca atatgccatc atgggttctg tttattctca gcaagtgcgc 1484221 ggtgtcactt caccgagagt cggactttta aatgtcggaa cagaagataa aaaaggaaac 1484281 gaactgacga agcagacgtt tcaaatttta aaagaaacag caaacatcaa ttttatcgga 1484341 aacgtggaag cgcgagacct tttagatgat gtggcggatg ttgtagtaac agacggcttt 1484401 accgggaatg ttacactcaa aacgctggaa ggctctgcgt tgtcaatttt taaaatgatg 1484461 agagacgtaa tgacgtctac tttgacatcc aagcttgcag cagctgtgct gaaaccaaaa 1484521 ttgaaagaaa tgaaaatgaa aatggagtat tcgaattatg gcggagcaag tctttttggc 1484581 ttaaaagcgc ctgtgatcaa ggcgcacggc tcttcagatt caaatgctgt attccatgcg 1484641 attcggcaag caagagagat ggtcagccaa aatgtggctg cgctcattca ggaagaagtg 1484701 aaagaagaaa aaacagatga gtagtctgga ggtttttaca tcatgagtaa gattgcattt 1484761 ttattcccgg gtcagggatc acaatttatc ggcatgggaa aagagcttta tgagcaggtg 1484821 cctgctgcaa agcgtctgtt tgatgaagcc gatgaaacgt tggaaacaaa actcagctcg 1484881 cttatttttg agggggatgc tgaagaatta acacttacat acaatgcgca gcctgctttg 1484941 cttacgacaa gcatcgctgt tcttgagaaa tttaaagaat ctggcattac acctgatttc 1485001 acagcaggac acagccttgg tgaatattct gcactggttg cggctggcgc tctgtctttc 1485061 aaagatgctg tttatactgt cagaaagcgc ggagagttta tgaatgaagc ggtgccggct 1485121 ggcgaaggag caatggctgc gattctcggc atggatgctg aagcattaaa gcaagtaacc 1485181 gataaagtca cagaggaagg caaccttgta cagcttgcga atctcaactg tcctggccaa 1485241 atcgtcattt ccggaacagc taaaggggtt gagcttgcat ctgaactggc aaaagagaac 1485301 ggcgcaaaac gcgcaattcc gcttgaagta agcggtccgt tccattctga actgatgaaa 1485361 ccggctgctg aaaagctgaa agaggtattg gacgcctgtg acataaaaga cgctgacgtt 1485421 ccggtcatct caaatgtttc tgctgacgtg atgactgaaa aagcagatat caaagaaaaa 1485481 cttattgagc agctttactc tccggttcgt tttgaggaaa gcattaacaa gctgatcgca 1485541 gagggtgtta cgacttttat tgaaatcggt cccggaaaag tgctttcagg ccttgtgaaa 1485601 aaagtgaata gacggttaaa aacaattgct gtatcagatc cggaaacgat cgagctggca 1485661 attcaaacgc ttaaggagga gaatgataat gcttaatgat aaaacggcta ttgtcactgg 1485721 cgcatcccgc ggaatcggcc gctcaatcgc ccttgatctg gcaaaaagcg gagcaaatgt 1485781 tgtcgtgaac tactccggca atgaagcgaa agcaaatgaa gtggtagatg aaatcaaatc 1485841 aatgggcaga aaagcaattg ctgtaaaagc ggatgtatca aatcccgaag atgtacaaaa 1485901 catgataaaa gaaacattgt ctgttttttc tacgattgac attctggtta ataatgcggg 1485961 aattacaaga gacaatctca tcatgagaat gaaagaagac gaatgggatg acgtcattaa 1486021 cattaacctg aagggtgttt tcaactgcac aaaagctgtt acaagacaaa tgatgaaaca 1486081 gcgttcaggc cgcattatta acgtatcgtc tatcgtcggc gtcagcggaa accctggaca 1486141 agccaactac gtggctgcaa aagccggcgt catcggttta accaaatctt ctgctaaaga 1486201 gctcgccagc cgaaatatta cggtaaacgc aatagcgcca ggatttatct caactgatat 1486261 gacagataaa cttgcaaaag acgttcaaga cgaaatgctg aaacaaattc cgctcgcgcg 1486321 ctttggtgaa cctagcgatg tcagcagtgt tgtcacgttc ctagcttcag agggagctcg 1486381 ttatatgaca ggccaaacgc ttcatattga cggcggaatg gtgatgtaag ttttttctcg 1486441 aaaatttcat cgtagtttct ctagtttttt aaaaacgaat ccactataat acttgagggg 1486501 aggtgaattg ctatggcaga cacattagag cgtgtaacga aaatcatcgt agatcgcctt 1486561 ggcgttgatg aagcagacgt caaacttgaa gcttctttca aggaagactt aggtgctgat 1486621 tccctagatg tagttgagct tgttatggaa cttgaagacg agtttgatat ggagatttct 1486681 gacgaagatg ctgaaaagat tgcaacagtc ggcgacgctg tgaactacat acaaaaccag 1486741 caataagctg atgctaaaag tcccgccgaa acgcggggct ttagcccttt attcgtgcag 1486801 ttattacagc atgccgcttt tacgcgcgct gtatccggtt tagtcagaga agcgcggtga 1486861 acctgatgtg cctatggagg ttactatgtc aaaacactca cattataaag ataaaaaaaa 1486921 gttctataaa aaagtagaac aatttaaaga gtttcaagaa cggatttcgg ttcactttca 1486981 aaatgaaaag cttttgtatc aagcatttac acattcatct tatgtgaatg agcatcggaa 1487041 aaagccgtat gaagataatg aaaggcttga atttttaggt gacgctgttt tggaactgac 1487101 gatctccaga ttcttatttg ccaaataccc ggctatgagt gaaggagatt tgacgaaatt 1487161 gagagccgca attgtttgcg aaccgtctct cgtttcattg gctcacgagc tgtcattcgg 1487221 cgatcttgtc ctgttgggta aaggcgagga aatgacaggc ggaagaaagc gtcctgctct 1487281 attggcggat gtttttgagg catttatcgg agccttgtac cttgaccaag gattagagcc 1487341 ggtcgaaagt ttcttaaaag tttatgtgtt ccctaaaatt aacgatggtg ctttttctca 1487401 tgtgatggat ttcaaaagcc agctgcagga atacgtgcag cgggacggca aaggctctct 1487461 ggagtataaa atctccaacg aaaaaggacc tgcgcacaac cgtgaatttg aagccatcgt 1487521 atctctaaaa ggtgaaccac tcggagtcgg aaacggccgt tcaaagaaag aagccgaaca 1487581 gcacgctgct caggaagctt tagctaaatt gcaaaaacac catacgaaac aataaaatcc 1487641 cccttatgac tcagggggat ttcagtatgt atgccgtctt atttgaccaa tgtttatgat 1487701 agaattgaaa tacttattac ataaggagga tcgctatgtt cctcaaacgt ttagacgtta 1487761 taggatttaa atcatttgca gaacggattt ccgtagactt cgttaaaggc gtgacagcag 1487821 ttgtcgggcc gaacggaagc ggaaaaagca acatcacgga tgccattcgc tgggttctcg 1487881 gcgaacaatc ggcacgctct cttcgcggcg gaaaaatgga agacatcatt tttgctggga 1487941 gtgattcaag aaagcgatta aatctagctg aagttacgct tactcttgat aatgatgatc 1488001 atttcttgcc aattgacttc cacgaggtga gtgtcacaag acgtgtgtac agatcaggtg 1488061 agagtgagtt tctgattaac aatcagccat gccgcttgaa agatattatt gatttattta 1488121 tggactctgg gcttggtaaa gaagcatttt ctattatcag ccaagggaaa gtggaagaga 1488181 tcctgagcag caaagcggag gatcgccgca gtatctttga agaagcggcc ggggtgctta 1488241 aatataaaac gagaaagaaa aaagcagaaa ataaactgtt tgagacacag gacaatctaa 1488301 atcgggtaga agatatatta catgagcttg aaggacaggt tgaacctctt aaaattcaag 1488361 cttcaatagc gaaagactac cttgagaaaa agaaagagct ggagcatgtt gaaattgcgc 1488421 tgactgccta tgatatcgaa gagctgcatg gtaaatggtc gactcttaaa gagaaagtgc 1488481 agatggcaaa agaagaagag cttgctgaat cgtctgctat ttctgcgaaa gaagcaaaga 1488541 ttgaggatac aagggacaaa atacaagcgc ttgatgagtc agtagatgag ctccagcaag 1488601 ttttactggt aactagtgaa gagctggaaa agcttgaagg ccgtaaagaa gtcctgaaag 1488661 aacgaaagaa aaacgctgtg caaaaccaag aacagcttga agaagccatc gttcagttcc 1488721 agcaaaaaga aacggttctg aaagaagagc tttcgaagca ggaagctgtc ttcgaaacgc 1488781 ttcaggctga ggtgaagcag ttaagggcgc aagtaaaaga aaaacagcag gctctcagtc 1488841 ttcacaatga aaatgtcgaa gagaaaatcg agcagctgaa aagtgattat tttgagctgt 1488901 taaacagcca ggcttcgata cgcaacgaac tccagcttct tgatgaccag atgtcccaat 1488961 ccgctgtcac attgcagaga cttgcggaca acaatgaaaa gcacctgcag gaacggcatg 1489021 atatttctgc gcgtaaagcc gcatgtgaaa cggaatttgc ccgaattgag caggagattc 1489081 acagtcaagt cggtgcatat cgtgatatgc agacaaaata tgagcagaaa aagcgccaat 1489141 acgaaaaaaa tgaatccgct ctgtatcagg cataccaata cgttcagcaa gcgagatcaa 1489201 aaaaggacat gcttgagacg atgcagggag atttctccgg cttttatcaa ggtgttaaag 1489261 aagtgctgaa agcgaaagag cgccttggcg gaattcgcgg agcggttctt gagctgattt 1489321 ctacagaaca gaagtatgaa acggccattg aaatagcgct cggcgcttct gctcaacacg 1489381 tcgtgaccga cgatgaacaa tctgcccgca aagcgattca atatttaaag cagaattcct 1489441 tcggccgggc gacgtttctg cctctttctg ttattagaga ccgccagctt caaagccgtg 1489501 acgcggaaac agccgcccgg cattcatcat ttctcggggt tgccagtgaa cttgtcacat 1489561 ttgatcctgc gtatcgaagc gtcatccaga atcttcttgg aaccgttctg atcacagagg 1489621 acttaaaggg tgcaaacgag cttgcgaagc ttctcgggca ccggtaccgc atcgtaaccc 1489681 ttgagggaga tgttgtgaac cccggtggtt caatgacggg cggcgcggtt aaaaagaaaa 1489741 ataactccct ccttggaaga agccgggagc tagaagatgt gacgaaacgg ctcgctgaaa 1489801 tggaagagaa aacggcactg cttgaacaag aggtcaaaac ccttaagcac tccattcagg 1489861 atatggagaa aaaactggct gacttaagag aaaccgggga aggcttaagg ttaaagcagc 1489921 aggatgtgaa aggccagctg tacgaacttc aagttgccga gaaaaatatc aatacccatt 1489981 tagagctcta tgatcaagaa aaatctgctc tgtcagaaag cgatgaagag agaaaagtgc 1490041 gcaaacgcaa gcttgaagaa gagctctctg ccgtatctga aaagatgaaa cagcttgaag 1490101 aggacataga cagactgaca aaacaaaaac aaacgcaatc ctcaacgaaa gagtctctct 1490161 ccaacgagct gactgagctg aagatcgcag cggccaaaaa agagcaggct tgcaaggggg 1490221 aagaggacaa ccttgccaga ttaaagaaag agctcactga aacagagctt gcgttaaaag 1490281 aagcaaaaga agacttaagc ttcttaacgt cagagatgtc atctagcacc agcggcgaag 1490341 aaaagctgga agaagcagca aaacataaat tgaatgacaa aacgaaaacg atcgaactga 1490401 ttgcattaag gcgcgatcag cgcatcaagc ttcagcatgg gcttgatacg tatgagcgtg 1490461 agctgaaaga aatgaaacgc ctgtataaac aaaaaacaac gctcttaaaa gacgaagaag 1490521 tcaaacttgg acgaatggaa gtcgagcttg ataatttact ccaatactta cgggaggaat 1490581 acagcttgtc ctttgagggg gcaaaagaga aatatcagct tgaaactgat ccagaggaag 1490641 ccagaaagcg cgtgaagctg attaaactcg caattgaaga gctgggtacc gtgaacctcg 1490701 gaagcataga tgagtttgag agggtcaacg aacggtacaa gtttctgtcg gaacaaaaag 1490761 aagatttaac agaagcgaaa aataccttgt tccaagtgat tgaagaaatg gatgaagaaa 1490821 tgacgaagcg ctttaacgac acattcgtcc aaatccgctc acactttgat caagttttcc 1490881 gctccttatt cggaggaggg cgagctgaac tgaggctcac cgatcctaac gatctgcttc 1490941 attcaggagt cgagattatc gctcagccgc cggggaaaaa gctgcaaaac ttaaacctcc 1491001 tgtcaggcgg agagcgtgcg cttactgcta tagcgctctt attctcaatc ctaaaggttc 1491061 gtccagtgcc gttttgcgtc cttgacgaag tagaggctgc gctcgacgaa gcgaatgtgt 1491121 tccgatttgc gcagtattta aaaaaataca gcagcgatac tcagtttatt gtgattaccc 1491181 acagaaaagg aacgatggag gaagcggatg tgctttatgg cgtaaccatg caggaatccg 1491241 gtgtttccaa ggtaatttca gttaagctgg aagaaacaaa agaattcgtt cagtaacgag 1491301 gaaagaggtt aaaagatgag cttttttaaa aaattaaaag agaaaatcac aaaacagaca 1491361 gattccgtat ctgaaaagtt taaggatggc cttgaaaaaa caagaaactc ctttcaaaac 1491421 aaagtgaatg atcttgtatc ccgttaccgt aaagtggatg aggatttctt cgaagagctt 1491481 gaagaggttc ttatcagcgc ggatgtcggt tttacaaccg ttatggaatt aatagatgag 1491541 ctgaaaaaag aagtcaaacg cagaaatatt caagatccaa aggaagtcca gtcagtgatt 1491601 tctgagaaac tggtcgagat ttataacagc ggagatgagc aaatttcaga actgaacatc 1491661 caggatgggc gtttaaacgt aatccttctg gtaggtgtaa acggcgtcgg gaaaacaaca 1491721 acgatcggaa agcttgctca taaaatgaaa caagaaggaa aatctgttgt acttgccgcc 1491781 ggagacactt ttagagcggg agccattgaa cagctggaag tatggggaga gcgtacagga 1491841 gtgcctgtca ttaagcagac ggcaggaagc gatccggcgg ctgtcatcta cgatgctgtt 1491901 catgctgcga aagcaagaaa tgccgatgta ttaatttgtg atacggcagg gcgtctccaa 1491961 aacaaagtaa atctcatgaa agagcttgaa aaagtaaaac gtgttatcga aagagaagtt 1492021 cctgaagctc cgcatgaggt gctgcttgcc cttgatgcca cgaccggcca aaatgcaatg 1492081 gctcaggcaa aagaattctc taaagcaaca aatgttaccg gcattgcttt aacgaagctt 1492141 gacggtacgg caaaaggcgg tatcgtcctt gcgattcgca acgagcttca catcccggtt 1492201 aaactagtcg gtttaggaga aaaagttgat gaccttcagg aatttgatcc agaatcctat 1492261 gtgtacggac tcttttcaga tttagtggaa aaagccgacg attaagaaaa aggccccaac 1492321 atcttggggc ctttttcttt tttatcttct tacttgatag gcgaaatgat aaaggctgtt 1492381 atcagtggat accagtcttg actcaccaga aaaaactctg aatgggatga tgtcatagta 1492441 atgaacggaa acagatgtgt aatacgtata gtaaccagca gctggcccca aatacattgg 1492501 aacctcaaat gttccgtttg catcagtcgt tcctgaagca gtttgtgttg tgtttccgac 1492561 cttcgtgtcc gcttcaaatc ttacgggcgc gtttggcact ggctgtccgt tttggtcgag 1492621 taatttgccg cttactgtaa tattgtactt gactcgccaa tattgacctt gtccgtaatt 1492681 gattttaccg tatacccctc catctgtgct gatatttgtg attgaggcct tataaggtgc 1492741 ctcagcagcg tctgcttgct gtgccgggaa acctattgta aacagggctg ccagacataa 1492801 cataaacaat aaaccgattt ttttcataaa aatcctcctt aaaatagggt tcatatacaa 1492861 tatcggaata aattggatga tatttagcgt attttggaaa agttaatcgc cgctttgaca 1492921 agataaaaac ttgacagtgt cattaaaacc gtgtaaacta agttatcgta aagggatttg 1492981 acttaacaaa ggggagagct caaatgtcac tcgaaaagac aacgagaatg aattatctgt 1493041 ttgattttta tcagtcgttg ttgacgtcaa aacagaagag ctatatgtcg ctttattatt 1493101 tggacgattt ctccctaggc gaaatagccg aagaatatga ggtttcaaga caagctgttt 1493161 atgataacat caaacgaaca gaagcaatgc ttgaacaata tgaagaaaag ctgctccttt 1493221 tgaaaaagtt tcaggagcgt aaagagatgt ttaataagct gaaggagctt gcttccggtt 1493281 caaaagaaga ggaagaaatt acagctctga ttgaagcgct tgagaaatta gattaggagg 1493341 cggcaaacta tggcatttga aggattagcc gaccgactgc agcagacgat ttctaaaatc 1493401 cgcggaaaag ggaaagtcag cgaacaagat gtaaaagaga tgatgcgtga ggtccgtctt 1493461 gcgctgcttg aggctgacgt taactttaaa gtagtcaagg attttgtcaa aaaagtaagt 1493521 gaacgcgctg taggccaaga cgtcatgaaa agtctgacgc ccggccagca ggtcattaaa 1493581 gttgttcaag aggaactgac tgagctgatg ggcggcgaag agagcaaaat cgccgtcgca 1493641 aaaaggccgc cgactgttat tatgatggtc ggtctccaag gtgccggtaa aacgacaaca 1493701 agcggtaagc ttgcgaatct gctgcgcaaa aagcataatc gcaaaccgat gctggttgct 1493761 gccgatattt accgcccagc cgcaattaag cagctggaaa cactcggcaa acagcttgat 1493821 atgcctgttt tctctcttgg cgatcaggtc agtcctgtag aaatagctaa acaggctatt 1493881 gagaaagcca aggaagaaca ttatgactac gtcattttgg atacggcagg gcgcttgcat 1493941 atcgaccatg aactgatgga tgaactgacc aacgtcaaag aaatcgcgaa tccggaagaa 1494001 attttcctgg ttgtcgattc aatgaccggt caggacgctg tgaatgttgc caaaagcttt 1494061 aatgaacagc tcggtttaac cggtgttgtg ttgactaagc tggatggaga cacacgcggc 1494121 ggggctgcgc tttctattcg cgctgtcaca aacacgccaa ttaagtttgc aggtttgggc 1494181 gaaaagcttg atgcgttaga gccgttccat cctgaacgca tggcatcaag gattctcggc 1494241 atgggcgacg tgctgacatt gattgaaaaa gcacaggcca gcgttgatga agacaaagcc 1494301 aaagagctgg aacaaaaaat gagaacgatg agcttcacat tggacgattt tctggagcag 1494361 ctcgggcaag tcagaaacat ggggccgctt gatgagcttc tgcaaatgat gccgggtgca 1494421 ggtaaaatga agggcctgaa aaacatccaa gttgatgaaa aacagctgaa tcatgtggaa 1494481 gcaatcatca aatcaatgac tgttcttgaa aaagaacagc cggatattat caatgccagc 1494541 cggcggaagc ggattgcaaa aggaagcggg acatccgtac aggaagtcaa ccgtctgctt 1494601 aagcagtttg atgaaatgaa aaaaatgatg aagcagatga caaacatgtc aaaaggcaag 1494661 aaaaaagggt ttaagctacc ttttatgtaa tcggttatac atgataaaac cgttgttaag 1494721 aaaaaacact ttacaaacac ttttatcatt gttaatatac tatcttgttg aaatattttc 1494781 ggaggtgcta gtaaaatggc agtaaaaatt cgtttaaaac gtatgggagc aaaaaaatct 1494841 cctttctatc gtattgttgt agcagattct cgttcaccac gtgacggccg tttcatcgaa 1494901 acagtcggaa cttacaaccc ggttgcaaaa ccagcggaag taaaaattga cgaagagctt 1494961 gctcttaaat ggcttcaaac tggagcgaaa ccatctgata cagttcgcaa cttgttctct 1495021 agccaaggaa tcatggaaaa attccacaac gctaaacaag gcaagtaatg actgatcaac 1495081 acttggaaga tttgattgtc cacattgtga cgccgcttgt tgatcatcca gatgacattc 1495141 gcgtcataag agaagaaacc gatcaaaaga ttgcgctgcg cttatctgtc cataagtcag 1495201 ataccggtaa agttatcgga aagcaaggcc ggactgcaaa agcgattcga acagctgtat 1495261 ttgcagctgg cgtacagtct tctaagaaag ttcaatttga aatatttgac taaaagggag 1495321 agggccggca cctccccttt ttttacacgc aaaaaaaggg taaactgata gaagcttagg 1495381 caaaatagaa aagcctggac gagtaaaagt tttaaaagcg gggagcttgg tgcgatgcaa 1495441 attattcacc gtgtagccgt tatgcaagtc ttaaccgagc gcagtaaaga aaagctttta 1495501 gcttcttttg ctgagaagaa acaaatgctt gaacgagaat gcagccagct ctattttcag 1495561 cttagaaaac atgagaaaga acagcaaaac cctaatatga ttgaacaatt taaaaaggca 1495621 atagaaaagc gaaaagatga tataaaaatc attgattttc aaattgctca agtacataca 1495681 ttgccgcttg gcagtgagtt gaaagaaaag gaagtcgatg cgctgctgac gattgaagcc 1495741 ggggatgact ggcatgagaa aacagcagcg aacaccatcg tcataaaaga cggaaaagta 1495801 attgaaattc gccagaggtg atcatatgac aaagcgatgg tttaatgtag gcaaaatcgt 1495861 aaatacccac ggaatcaaag gcgaagtgcg ggtgatttca aaaacagatt ttgccgaaga 1495921 acgatacaag ccgggaaaca cgctgtattt gtttatggac ggccgtaacg aaccagtgga 1495981 ggtaacggta aacacacata gactgcataa gcaatttcat ctcctgcagt ttaaagaaag 1496041 acaaaaccta aatgaagtag aagagctgaa aaacgcaatc attaaagttc ctgaagaaga 1496101 attaggagag ctgaatgagg gtgaatttta tttccacgaa attattgggt gtgaagtatt 1496161 tactgaagaa ggcgaactca tcggaaaggt caaagaaatt ttgacgcctg gagccaatga 1496221 cgtttgggtc atcggacgaa aaggaaaaaa agacgcactc attccttaca ttgaatcagt 1496281 ggttaaacat atcgatgtca gggaaaagaa aattgagatt gaactcatgg aagggttaat 1496341 agacgaatga aaatcgattt tttgacgctg tttcccgaaa tgtttgaagg cgtgctcggc 1496401 tcatcgattc ttcaaaaagc ccaggaaaaa gatgcggtgc agtttcaagt cgtaaatttc 1496461 cgagagtact ctgataacaa gcacaatact gttgatgatt atccttatgg cggcggggca 1496521 ggcatggttc tcaagcccca gcctgttttt gacgcggtcg aggacctgac atcaaaggca 1496581 gccgctgctc cgcgtattat cctcgtatgc ccgcaaggtg agcgttttac ccaaaaaaaa 1496641 gccgaacaat tagctaagga agagcatttg ctgttcattt gcggccacta tgaaggctat 1496701 gatgaacgca ttcgcgagca cttggtaacg gatgaaatat caattggcga ctttgttctg 1496761 acgggcggtg agctccctgc aatgatgatc gcagacagtg tggtcagact gcttccgggt 1496821 gtactgggta aagaggcttc ccatattgag gattccttca gcaccggact tttagagcac 1496881 ccgcattata caagaccggc agattacaaa ggtttaaaag tgcctgaaac actcttgtca 1496941 ggaaaccatg caaaaattga agaatggcgg aataaagaat cgatcagaag gacctaccta 1497001 agacgtccgg atctgttgaa agaccacccg cttacagagc agcaaagaaa gtggatttct 1497061 gaatgggaaa aagaatagat tttattgcat aggctatgaa attgtgataa gatactactt 1497121 gtggcttaag cgggcttatc cgctgcaagc ttgaaaacga tgttccgctg tgccggtttt 1497181 tgtggccaag agcatctgtt ggaaggagtt gaaaacgatg caaaaactaa ttgaagatat 1497241 cacaaaagaa cagcttcgta ctgatcttcc tgcgttccgt cctggtgaca ctttacgtgt 1497301 acacgttaaa gttgttgagg gtaaccgtga gcgtatccag atctttgaag gtgttgtgat 1497361 taagcgtcgt ggtggtggaa tcagcgaaac gttcacagtt cgtaagattt cttacggtgt 1497421 tggcgttgaa cgtactttcc cagtacacac accaaaaatc gcgaaaatcg aagttgtacg 1497481 ttacggtaaa gtacgccgtg ctaaacttta ctacctgcgt gaacttcgcg gaaaagcggc 1497541 tcgtattaaa gagatcagac gataatgata acgaacgaaa agagcttgtt acctgtaaca 1497601 agctcttttt ttatacagaa tttgaaaatg ccggacaggc atcgtaaaat acataaagga 1497661 caacaatgaa tcatgcatac tgaagataaa ggcggtgttc gtgtcacatg acaattcaat 1497721 ggttcccggg ccatatggca aaagcaagaa gggaagtaac cgaaaaatta aaattaatcg 1497781 atatcgtata tgaattggta gatgccagaa ttccaatgtc atcaagaaac ccaatgattg 1497841 aagatattct aaaaaacaag ccgcgaatta tgctgttaaa caaggctgac aaagcagatg 1497901 cggcagttac acagcagtgg aaagagcact ttgagaacca ggggatccgc tctctgtcta 1497961 ttaattctgt aaatggacaa gggttaaatc aaattgtgcc tgcatcaaaa gagatcctcc 1498021 aagaaaaatt tgaccggatg cgtgcgaaag gtgtgaagcc gagagcgatt cgcgctttga 1498081 ttatcggcat tccaaacgtc ggaaaatcaa cgctcatcaa ccggcttgca aagaaaaaca 1498141 tagcaaaaac gggagacaga cctggtatta cgacttctca acagtgggtc aaagttggga 1498201 aagaattaga gctattagat acaccgggaa ttttgtggcc taaatttgag gatgagcttg 1498261 tcggtttgag actggcagtc accggggcta ttaaagactc gattatcaat ttgcaggacg 1498321 tggccgtgtt tggtcttcgt tttctcgaag aacattaccc agaacggctt aaagagcgtt 1498381 atggccttga tgagatccca gaggacattg ccgagctgtt tgatgcaata ggtgaaaagc 1498441 ggggctgtct catgagcggt gggctcatca actacgataa gacgactgaa gtcatcattc 1498501 gcgatattcg cactgaaaag ttcggcaggc tgtcatttga acagccgacg atgtaaaggc 1498561 gcgcagaaat gcgggtcttt attttttctt ggctgaaccg atacatacag taagggagaa 1498621 gagaaagtga atacattaac cgtaaaggac attaaagacc gtttgcagga agtgaaggat 1498681 gcacaagacc catttattgc ccaatgcgaa aacgacccga gaaaaagcgt tcaaacgctt 1498741 gtagagcaat ggcttaaaaa gcaagcgaaa gaaaaagcgc tgaaagaaca atgggtgaat 1498801 atgacttcct atgaaaggct ggcaagaaac aaaggatttc gcttgattgc aggtgttgac 1498861 gaggtcggcc gggggccatt ggcaggacca gttgtcgcca gcgcagtcat ccttccagag 1498921 gaatgtgaaa tacttgggct gacagactcc aaaaagcttt cagagaaaaa acgcgaggaa 1498981 tattacgagc ttattatgaa ggaagcactg gcggtcggga taggaattgt agaagctact 1499041 gtgattgatg agatcaatat atatgaagct tcaaaaatgg caatggtgaa agcgatacag 1499101 gatttgtcgg atacacctga ttatttgctt gttgacgcaa tgacacttcc gctcgacacg 1499161 gctcaggcgt caattataaa aggcgatgcc aaaagcgtgt ctattgcggc aggtgcgtgt 1499221 atcgcaaaag tgacgaggga ccgaatgatg agcgcttatg ccgaaacgta tcccatgtac 1499281 ggctttgaaa aaaataaagg ctatgggaca aaagaacatt tggaagctct cgctgcatac 1499341 ggcccaactg aattgcaccg caaaactttc gctcctgttc aatctttcag ataaatcacc 1499401 atggacaagg aggcaccttt ttaaaatgaa catacgaaat gatgtgcaaa aggcgctgca 1499461 gcaccttttc gggcgtacag ccgtcccgca ggaaacatca aaagtaaacg aagcgctaaa 1499521 cggggagaag cgtctcctct taggaaaagt gcttcgttta ctaggagatc agcatgccct 1499581 gatccaagtc ggcaatcaaa ctgttcaggg aaaacttgaa actcagcttc gtcctcaggc 1499641 atactattgg ttttcctacg aaaaaaaaac ggcagagcaa acaggccgtc ttcaggtcgt 1499701 tcaaagcttt gatcaaaatc ctaaaaccat tcaggatgca gctggcaaac ttttaaatgc 1499761 tatttcagtg aagacgtcaa acgcagctct catgatgaca ggagcgatgc tgaaaagcaa 1499821 aacacccgta acagaaaatg atatcaaaac agctgtccgc tggatggaca cgctgccttc 1499881 gcaagacaca aaaaaagcag ttgaaacggt tctcttcgct ttaaagcgtg atcttcccat 1499941 tcactccgag attttgaatg gtgttcacgc tgtgaaatcg cctgttccgt tgcatcagca 1500001 cgtatcccag ctgctacagg caatcgacca aaaccctcag cagagccaaa tgatgtcaaa 1500061 gctaaaggaa gcagtcacgg tgcttttaaa tagtgaaatc gatgtccatg cagaacggct 1500121 gattgataag cttatttctt taaccgacaa tacgaaagca ccttctccga cgaatacagc 1500181 tggaagcagg gagcttagca caccagctgg ctcccccgga aaagccagcc tgccgattgc 1500241 aaatcacaca gcagaacagg gaagcataca agaagagcct gttaaaacag cagcagacat 1500301 tccaattaaa gaagcccgcc agctgctggt gaagctgacg gaatctgctg aaaaaaacag 1500361 tctccaaatt gtgaaagaag cagcaaattg gattaaagcg gctgcttcat cgggtgatag 1500421 taagtcactt gcagcttcag ctgttttaca ggcggcacaa gtcacagatc aggaagccga 1500481 agtcttttta aaggctgttc agcagacagc accccatttg gcggataagg cagatgttct 1500541 ttctttctta tccaaagtga aaacggcaat cggcgcaagg gacgaggttg cgttcattaa 1500601 agcgtttgaa caaggaagcg cagtcacatc tggcgaaatg caatccatca agctggctct 1500661 ttctgcctta agagcatcgc atgaggtagc cgaaccagtc aaacaagaag ccgatcagct 1500721 ttttcataaa ttaaatggcc agcttttcat gcagcaggac catccatcat acagccaaat 1500781 tgtaatgtca tttccgatgt tttcgaagtc aggggttcag gacatgactg ttctgtttaa 1500841 aggaaagaaa gaagcggatg gaaagcttga tccttcccat tgccgccttt tgtttttgct 1500901 gcagcttgat acactaaaag aaaccgtcgt tgattgcttg gtacagcaaa aagtcatgac 1500961 cattacaata gagactgatt tcgagctgca ggctgcgatc gatccgatgg tgcccgcgct 1501021 taaacagggg ctaaaggaaa tggggtacag cctttcaggg gtaaacgcta aaaaaagggt 1501081 tcacaccgaa gaaaaggctt caatcgatca atatataaca agtatcagtg atcaggaagt 1501141 ggatgtgaaa atatgaaaga gcagacaccg atcagaaaag ctgttgctct ccattatgac 1501201 gaacaaaaag acaaggcgcc gagagtgatt gccacaggga agggccatgt agctgacaac 1501261 attataaaag aagcgaaaaa agcaggggtc ccgattcaag aagatcggac ccttgtcgaa 1501321 ttaatgcgcc atttgacggt agatgatcaa attcctgaag ctctttatga aacggtagcc 1501381 gagatttttt cattcattta caaattggac gaaagcgtaa aaaacaaaaa atagctaaaa 1501441 tattccccat ccttctttga aatttatgtt tttaataaag taaaagtttg aatgtttaga 1501501 aggattaaaa gattttgcat cgaactgtag acaattcttc cagtattatt atagaatgaa 1501561 agcgcagtct attttagttt tgttacataa gttaggagga tgggaaatga atatccatga 1501621 gtaccaggga aaagaagtcc tcagaaaata tggggtatct gttcctgaag gtaaagtggc 1501681 ttttacagca gaagaagcag ttgagagtgc aaagagctta tccagctcgg tttatgtcgt 1501741 aaaggctcaa attcatgctg gcggtcgagg caaagctggt ggggtaaaaa tagcaaaatc 1501801 attagacgaa gtaaaagcgt atgccgaaga actattaggg aagaccctag ttacacatca 1501861 gacgggtccg gacggccaag taataaaacg cttacttatt gaagaaggct gcgatattaa 1501921 aaaagaatat tacatcggtc tagtgcttga ccgcgccact tcaagaatcg ttttaatggc 1501981 ttctgaagaa ggcggaacgg aaattgaaga ggttgcggag aaaacaccag aaaaaatcaa 1502041 aaaagctgtc attgatccag ctgttggcct tcaaggctat caagccagag aaattgcatt 1502101 cgctattaat attccaaaag agctcgtggg aaaagctgct aaatttatgc ttggactata 1502161 taaagcgttt gttgagaaag actgctcaat cgccgaaatc aatccgcttg ttgtgactgg 1502221 cgacggaaat gtgatggcgc ttgatgcaaa attgaatttt gacagcaatg cgttgtaccg 1502281 acaaaaggac attatggaat acagagattt ggatgaagaa gatccgaaag aaattgaagc 1502341 gtccaaatat gatctaagct acatttccct tgatggaaat atcggctgta tggtaaacgg 1502401 cgcgggactt gcaatgtcta cgatggatat tatcaagcat tatggaggag aaccggccaa 1502461 cttccttgat gtgggcggcg gtgcaaccgc ggaaaaagtc acggaagcat ttaaaatcat 1502521 tctttctgat caaaacgtta aagggatttt tgtcaacatt ttcggcggca ttatgaaatg 1502581 tgatgtcatc gcagaagggg ttgttgaagc gactagacaa gttggtttga cattgccgct 1502641 tgtcgtccgt cttgaaggca caaacgtgga tctagggaag aaaatcctta gtgaatcagg 1502701 attaaacatt acatctgcgg aatcaatggc tgacggcgcg cagaaaatcg tatccttagt 1502761 ttaagaaaga atgaaaggca ggggaccaaa taatgagtgt tttcattaat aaagatacaa 1502821 gagttattgt gcaagggatt acaggttcta ccgctttatt tcatacgaag cagatgcttg 1502881 aatacggcac aaatatcgtt ggcggtgtaa cacctggaaa aggcggaaca gaagcggaag 1502941 gtgttcctgt atttaataca gtggctgaag cagttcaaac aaccggcgct aacgcgtctg 1503001 ttatatatgt gcccgcaccg tttgcagctg atgcgattat ggaagcggta gatgcggagc 1503061 ttgatctcgt gatttgtatc acagaacata tcccggtttt ggatatggtg aaggtcaaac 1503121 gcttcatgga aggcaagaaa acgagactga tagggccgaa ctgtcctggt gtcattacgc 1503181 ctgaagaatg taaaatcggc attatgcccg gatacatcca taaaaagggt catgtaggcg 1503241 ttgtatcacg ttcaggaaca ttaacatacg aagcggtgca ccagctctca gaagcgggtg 1503301 tagggcaatc tacagctgtt ggaatcggcg gcgaccctgt aaatggaaca aactttattg 1503361 acgttttaaa agcgtttaac gaagatcctg acacacacgc agtcatcatg attggcgaaa 1503421 tcggcggtac ggccgaagag gaagcggcag agtgggtaaa agccaacatg acaaaaccgg 1503481 tagtcggttt tattggcggt aaaacagcac ctcctgggaa gcgcatgggg catgcaggcg 1503541 ccattatttc cggcgggaaa gggacagctg atgaaaaaat caaaaccctt aatgcatgcg 1503601 gaatcgaagt tgcagagaca ccttctgtca tgggtgaaac cttaatcaag gtgctgaaag 1503661 agaagaactt gttcgaaact tgtaaaacgc attaataaaa aagggacagc cgtcaaggct 1503721 gttcctgctt tttctaacaa aaggaggtca atctattgga tcaggccgct gtctgcctaa 1503781 cgatttgcag aatcaatcaa ttattatccc catcccttct attaaaatgg tggaaagccg 1503841 atccgtctat gtcgctgaca tcacccgtgt tacaaacggt tactcgtgat caaataaaag 1503901 cagctgcatt aaaaaacgaa atagaacaat tttatccaaa gctcccgcgt gtacttgctg 1503961 cttatcgtga gcaaggcatt aacaccatcc ctatttcttc aaagcaatat cctttctggc 1504021 ttaaaagcat ttatgatccc cctgccgtac tgtttgcaaa aggtgatatg actcttcttt 1504081 cgaaagggag aaaaattgga attgtaggca caagaaatcc aacagcttat gggaaacaag 1504141 ttgtcaatca tcttacaaaa gagatctgtc gtaaaggttg ggtgattgtc agcggactgg 1504201 cgtctgggat agacggaatg tcccatgctg caagtattaa ggcgaagggg cggacaattg 1504261 gcgtcattgc aggcggattt caacacattt atccccgaga aaaccttcag ttagcagatc 1504321 acatggctaa acaccatatc ctgctgtcag agcacccacc tgaaactaaa ccccaaaaat 1504381 ggcatttccc tatgagaaac cgtattatca gcggactaag tgaaggcgtt attgtcgttc 1504441 agggcaaaga aaaaagcggt tcgctgatta ctgcctatca agcattggaa caagggagag 1504501 aggtatttgc cgtacccggt tcattgtttg acccttacgc cggaggtcct ataaaactga 1504561 tccagcaggg ggctaaagcc atatggtcag cagaggatat tttcgaggaa cttcctgaga 1504621 gaaacgttca atatacggaa cccttttgaa ttatcgtttg acaaacggta ttgtaatatt 1504681 taataatagt gaggatttaa agttgcatat tgttttctat ttaattaatg acgttcatga 1504741 taaagaatga aatgttgaaa gccaaataaa gacagctgca aaaataaaat tgaaatatct 1504801 tgaaaagaga gagaacacct cttgaggggg atgaaaatgt ctgattatct agtcatcgtg 1504861 gaatcgcccg ctaaggcgaa aacgattgaa cgttacttag gtaaaaaata taaagtaaaa 1504921 gcatcaatgg gacatgtccg ggatcttcca aaaagtcaaa tgggagttga catagaacag 1504981 aattttgaac cgaaatatat taccattcga ggtaaaggcc cggtattaaa agagctgaaa 1505041 acggctgcga aaaaagccaa aaaagtgtat ctcgcagctg accccgacag agaaggggaa 1505101 gcgattgcat ggcatttggc acacagtctt gatttagatc tcaactcaga ctgccgtgtg 1505161 gtgtttaacg aaattacaaa agacgctatt aaggaatcgt ttaagcatcc ccgcatgatc 1505221 aatatggatt tagtggatgc acagcaagcg agacgtattt tagacaggct tgtcggatat 1505281 aaaatcagtc caatcttatg gaaaaaagtc aaaaaagggc ttagcgcagg acgcgtgcaa 1505341 tccgttgccc tccgtttgat tattgaccgt gaaaaagaga ttaacgactt taagcctgag 1505401 gaatattgga caattgacgg tacgttctta aaaggtcaag aaacctttga agcgagcttt 1505461 ttcgggaaaa acggcaaaaa acttccttta aatagtgaag ctgatgtaaa agagattctt 1505521 tctcagctca aagggaatca atatacagtt gaaaaagtaa ccaaaaagga acgcaaacgt 1505581 aatcctgctt tgccttttac cacttctacc ctgcagcagg aagcggctcg caagctcaat 1505641 ttcagagcga agaaaacgat gatgattgca cagcaattat atgaaggaat tgatttagga 1505701 agagaaggaa cggttggtct gatcacgtat atgagaacgg attcaacccg tatttcaaat 1505761 acggctgttg atgaagcagc tgcatttatt gatcagacat atggaaaaga gttcctaggc 1505821 ggaaaacgga agcctgcgaa aaagaatgaa aatgcccagg atgcccacga agcaattcgg 1505881 ccgacatcag ttcttagaaa accaagtgaa ttaaaagcag tcctcggcag agaccaaatg 1505941 agactgtata aattaatttg ggagcgtttt gttgccagcc aaatggcacc ggctgttctc 1506001 gatacaatga gtgtcgacct gacaaacaac ggtttgacat ttcgtgcaaa tggaagtaaa 1506061 gtcaagtttt ccgggtttat gaaggtgtat gttgaaggaa aagacgatca aatggaagaa 1506121 aaagaccgga tgctgcctga cttacaagaa ggcgacacgg tattatcaaa agatatagaa 1506181 cctgagcagc attttaccca gccgcctccg cgatatactg aggcccggct tgttaaaacc 1506241 cttgaagaac gcggtatcgg ccgtccatcc acatatgctc cgacacttga tactattcag 1506301 cggcgcggct acgtggcatt ggataataaa cgtttcgttc cgactgaatt aggtcagatc 1506361 gttcttgact tgatcatgga gtttttccct gagatcatta acgttgagtt tacagctaaa 1506421 atggagagag atcttgatca tgttgaagaa ggaaataccg aatgggtcaa gattatcgat 1506481 aatttctaca ccgattttga aaaacgcgtc aaaaaagccg aatcggaaat gaaggaagtt 1506541 gagattgaac cagagtatgc tggagaggat tgtgaattgt gcagttctcc aatggtatat 1506601 aaaatgggac ggtacggtaa attcttagct tgctccaact tccctgactg ccggaacacg 1506661 aaaccgattg tgaaacaaat cggtgtgaag tgcccgagct gcggagaagg aaacattgtt 1506721 gagcgaaaat cgaaaaagaa acgggtgttt tacggctgtg accgttatcc ggactgtgaa 1506781 ttcgtatcat gggacaaacc aattgaacga aaatgcccga aatgcggaaa aatgctcgtc 1506841 gagaaaaaac tcaaaaaagg tatacaagtc caatgcgtgg aatgcgatta taaggaagaa 1506901 ccacagaagt agcggtgagc agggtcttgc tcaccttctt tgtgtgttaa aagaaggcct 1506961 tgaataataa actaggagat gtgaaagatg aaccaacaaa cagtgaatgt aatcggagcc 1507021 ggactcgcag gaagtgaagc agcatggcag cttgccaaac gtgggattca agtcaaattg 1507081 tatgaaatgc ggccagttaa acaaacgcct gcgcatcata cagataaatt tgctgagctt 1507141 gtctgcagca actctcttcg ctctaataca cttgctaacg ctgtcggtgt attaaaggaa 1507201 gaaatgcgtg cgcttgattc agccattatc gctgcggctg acgaatgttc ggtgcctgcc 1507261 gggggcgctc ttgcagtaga ccgtcatgaa tttgccgcaa gtgtgacaaa tcgggtgaaa 1507321 aatcatccaa acgtaaccgt tattaatgaa gaagtgactg aaattcctga aggccctact 1507381 atcatcgcaa cgggtccgtt aacatctgaa tcgctgtctg cccagctgaa ggagctgact 1507441 ggagaggact atttatattt ttatgacgca gcggcgccaa ttgtagaaaa agacagcctt 1507501 gatatggata aagtgtacct gaaatcccgt tatgataaag gtgaagcagc atatttgaac 1507561 tgcccgatga cagaagaaga gtttgaccgt tttcatgaag cattaacatc agcagaaaca 1507621 gtgccgttaa aagaatttga aaaagagatt ttctttgaag gctgcatgcc gattgaagtc 1507681 atggcaaaac ggggtaagaa aacaatgctt ttcggtccga tgaaaccagt tggtctagag 1507741 catcctgtta caggaaaacg cccttatgcc gtcgttcagc tcagacagga tgatgctgcg 1507801 ggaacacttt ataatattgt aggattccag acacatttaa aatggggaga ccaaaaggaa 1507861 gttctcaagt tgattccagg acttgaaaat gtagaaatcg tcagatatgg cgtgatgcat 1507921 agaaacacat ttattaactc tccaagcctg ttaaagccga cttatcaatt taaaaaccgc 1507981 agtgatctgt tctttgcagg ccaaatgacg ggagtagaag gatatgtgga atcagctgcc 1508041 tcaggacttg tagcaggcat taatgcggcg aagcttgtat tgggagaaga gcttgtgatc 1508101 ttccctcagg aaacagcaat tggcagtatg gcacattata ttacaacaac aaaccagaag 1508161 aacttccagc cgatgaatgc aaactttggg cttttgaaag aattgccagt taaaattaaa 1508221 aataaaaaag aacgaaatga acaatacgcg aaccgtgcga ttgaaacaat tcaaacaatt 1508281 tcgaaaacaa tataggtatt gattgcaacc tgagcgcgat ttgtgatacc atttaaaagc 1508341 ccttcctggg gaggtattag gcatggagaa tgttaagaat ttcgtaaagt tattcgttga 1508401 atatttacaa attgaaaaaa attattcaca atatactatt gtgaattatg tggattcaat 1508461 tgaagaattc gagactttcc tgcgcgttca aggtataaat ggatttgaag aagctgcata 1508521 tcaagatact aggatttttt tgacagaagc ctatgaaaaa ggtttatcga gaagaacaat 1508581 aagcaaaaag atatctgcat taagaagctt ttataagttt ctgatgcggg aaaagcttat 1508641 tgaagaaaat ccgtttcagc ttgttcatct gccaaaacag gagaaacgga taccgaagtt 1508701 tctatatcaa aaagagcttg aggagctgtt tgaagtttca gatataagcc agccggccgg 1508761 aatgagggat caagcgctgt tagagctgct ctatgccact ggaatgaggg tcagtgaatg 1508821 ctgttccata actattaacg acgttgattt atttatggac actgtgcttg ttcacggtaa 1508881 aggcaagaag cagcgctata tcccctttgg gtcttatgcc cgcgaagcgt tgaaggtata 1508941 catgaatagc ggaagacagt gcttgctgat gaaggcaaaa gaacctcatg atctattatt 1509001 cgtaaatcaa agaggcggac cgcttacagc ccgtggcatc agacatattt taagcgggct 1509061 tgttcaaaaa gcgtcaagca ctttacatat ccatccgcat atgcttcgac atacgttcgc 1509121 cacgcatctg ttaaatgaag gagcggattt gagaagcgtt caagaactgc tcgggcattc 1509181 caatctgtct tctacacaga tatacacgca cgtttcgaag gaaatgttga gaaacacata 1509241 tatgtctcac catccaagag catttaagaa aaattaaagg aggcccttta tgtcatcttt 1509301 tcatgcgacc acaatatttg ccgtacagca taaaggacga agcgctatgt ccggagacgg 1509361 ccaagtaaca tttggtcagg ctgttgtcat gaaacacacg gcacggaaag tgagaaaact 1509421 gtttaacggc aaagttcttg ctggttttgc gggatctgtt gcagacgctt tcactttatt 1509481 cgaaaagttt gaagctaagc ttgaagaata taacggcaac ttaaaacggg cggctgttga 1509541 gcttgcaaag gaatggcgca gtgataaagt gctaagaaag ctcgaagcca tgctgattgt 1509601 tatgaatcag gatactttgc ttctcgtatc gggaacaggc gaggtgatcg aaccagatga 1509661 cggcattctc gcgattggat caggaggcaa ttacgctttg gcagcgggaa gagcactgaa 1509721 aaagcatgcc ggggaaagca tgtctgcaag tgagattgcc agagccgcgt tagaaacagc 1509781 aggcgaaatt tgtgtttaca cgaacgatca aatcatactg gaagagcttg aatagaaagg 1509841 acttgaggcg catggaaaaa aaaccgttaa ctcctagaca gattgtagat cggttagacc 1509901 aatatattgt cggtcagcaa aatgcgaaaa aagctgtcgc cgtggcatta agaaaccgct 1509961 atagaagaag tcttctggat gaaaagctga aggacgaggt cgttccgaaa aacattttaa 1510021 tgatgggtcc taccggcgtc gggaaaactg aaattgccag acgaatcgct aagctttcag 1510081 gtgcgccatt tatcaaaatt gaagctacta aatttaccga agtcggctat gtaggcagag 1510141 atgttgaatc aatggtcaga gatcttgtgg agacttctgt tcggcttata aaagaagaga 1510201 aaatgaatga agtaaaggaa caggcagaag aaaatgcaaa caaacgcatt gttcgtctgt 1510261 tagttcctgg gaagaaaaaa caatctggtg ttaaaaatcc gtttgaaatg ttttttggag 1510321 gcagccagcc gaatggtgaa gatgaggcgg agagccagga agaagcaaac atcgaagaaa 1510381 aaagaaaacg aatggcgcat cagctggctt taggagagct cgaagactac tatgtaacag 1510441 tagaagtcga agaacagcag ccttctatgt ttgacatgct gcagggctcg ggtatggagc 1510501 agatgggtat gaacatgcag gatgcgctga gcggattaat gccaaagaaa aagaagcggc 1510561 gcaaaatgac agtcagagaa gccagaaaag tcctgacgaa tgaagaagca agcaaactca 1510621 tcgatatgga tgaagtcggc caggaagctg ttcagagagc agaagagagc gggattatct 1510681 ttatcgatga gattgataaa atcgcaaaga acggcggtgc atcttcttct gccgatgttt 1510741 caagagaagg tgttcagcgg gatatccttc cgattgttga aggttctacc gttgtcacaa 1510801 aatatggttc tgtaaaaaca gaccatgtat tatttattgc agcaggagcg tttcatatgg 1510861 ccaaaccgtc tgatttgatt cctgagctgc aggggcgttt cccgattcgt gtagaactga 1510921 acaaactcac ggtagacgac ttcgtgagaa ttttggttga gccggataat gcgctgctga 1510981 aacaatatca ggcattattg cagacagaag gtatatctct tgaattttct gacgaagcta 1511041 ttcataagat tgctgaagtt gcttatcatg tgaaccagga cacagataat atcggtgcga 1511101 gacgccttca tacaatactt gaacgcctat tagaagattt gtcgtttgaa gctccagatg 1511161 taacgatgga gaaaataacg attacaccac agtatgtcga agaaaagctc ggaacgatag 1511221 ccaaaaacaa agatttaagt caatttatat tgtgaaaaat ttaatatgag gaatgtttag 1511281 gaggattatt tatcatggct ttattacaaa aaacaagaat tattaactcc atgctgcaag 1511341 ctgcggcagg gaaaccggta aacttcaagg aaatggcgga gacgctgcgg gatgtaattg 1511401 attccaatat tttcgttgta agccgcagag ggaaactcct tgggtattca attaaccagc 1511461 aaattgaaaa tgatcgtatg aaaaaaatgc ttgaggatcg tcaattccct gaagaatata 1511521 cgaaaaatct gtttaatgtc cctgaaacat cttctaactt ggatattaat agtgaatata 1511581 ctgctttccc tgttgagaac agagacctgt ttcaagctgg tttaacaaca attgtgccga 1511641 tcatcggagg cggggaaaga ttaggaacac ttattctttc gcgtttacaa gatcaattca 1511701 atgacgatga cttaattcta gctgaatacg gcgcaacagt tgtcggaatg gaaatcctaa 1511761 gagaaaaagc agaagaaatt gaagaggaag caagaagcaa agctgtcgta caaatggcta 1511821 tcagctcgct ttcttacagt gagcttgaag caattgagca catttttgag gagcttgacg 1511881 gaaatgaagg tcttcttgtt gcaagtaaaa ttgctgaccg tgtcggcatt acccgttctg 1511941 ttattgtgaa cgcactcaga aagctggaga gcgccggtgt tatcgagtct agatcattag 1512001 gaatgaaagg tacttatatc aaggtactaa acaacaaatt cctaattgaa ttagaaaatc 1512061 taaaatctca ttaatcacaa aaagaaccct ttttgagggt tcttttttta tttcaaataa 1512121 aggaaatcaa taagctttat ttcctgggtt gaaagtcttt ctatgtaata attttaataa 1512181 attttgcatt tttcttcaaa aagtttcaaa aatgccgaaa agaaaggaga aaaaacagaa 1512241 attctgctat tttcaggctt atatcaaggc gagaaatgta gttctaacaa tctaggactt 1512301 tatacctagt tgcaaaatag ataattgtga ggacattttt ttacacgaac ttcatagact 1512361 ttatgcctgt tatttcttac aataagcata tagttttaca attctcgaca aggatattga 1512421 gggtgaaaaa aactgaaatg gaggtaagtg gatttgagct tattttctgg aacgatacaa 1512481 aatcttgaaa atgccttgag cagagcggat attaagcaaa aagtcataac taataatatc 1512541 gccaatatag atacaccgaa ctataaggca aaaaaagtct ctttccaaaa tttattagat 1512601 caagaatcct cgcgtcttga agcgataaaa acagactatc gtcatgttga tttttctgat 1512661 actgattcga attattcaat tgttgcgagc ggagatacat cgtatcagca aaacggaaac 1512721 aatgttgatg ttgacaaaga gatgacagaa ttggcgcaaa atcaaatcaa ctatcaagct 1512781 ttggttgaaa gaatgaacgg taaatttaat tcgctgaaga ccgtattaac aggaggaaaa 1512841 tgatgacagc ttttcatagc ttaaatgttt cagcatcggc tttaacagct cagcgagtca 1512901 gaatggacgt tgtatcatct aacttagcaa atatggatac gacaagagct aagcaggtga 1512961 atggagagtg ggtgccttac agaagaaaaa tggtttccct tcagtcaaaa ggtgaatcgt 1513021 tctcttccat tctcaattct caaatgagcg gaagcgggaa tgctggaaac ggtgtgaagg 1513081 tttcaaaaat tacggaggat gattcggatt ttaatcttgt ctatgatccg acagaccctg 1513141 atgcaaacgc tgaaggatat gtacaaaagc ctaatgttga tccattaaag gaaatggttg 1513201 atcttgtcag cagcactaga tcatacgagg cgaatgtcac ggcgatgaat gccacaaagg 1513261 gaatgctgat gaaggcgtta gaaatcggaa agtaggcgaa ctgttaaaca aggtgaaaaa 1513321 acgatttaat taaggtatta gggggataac aatgcaatcc ttgaattatg aagatcaggt 1513381 gctttggacg cgctggaaag agtggaaaga tcctaaagcc ggtgacgact taatgcgccg 1513441 ttacatgccg cttgtcacat atcatgtagg cagaatttct gtcggactgc cgaaatcagt 1513501 gcataaagac gatcttatga gccttggtat gcttggttta tatgatgccc ttgaaaaatt 1513561 tgaccccagc cgggacttaa aatttgatac ctacgcctcg tttagaattc gcggcgcaat 1513621 catagacggg cttcgtaaag aagattggct gcccagaacc tcgcgcgaaa aaacaaaaaa 1513681 ggttgaagca gcaattgaaa agcttgaaca gcggtatctt cggaatgtat cgcccgcgga 1513741 aattgcagag gaactcggaa tgacggtaca ggatgtcgtg tcaacaatga atgaaggttt 1513801 ttttgcaaat ctgctgtcaa ttgatgaaaa gctccatgat caagatgacg gggaaaacat 1513861 tcaagtcatg atcagagatg acaaaaatgt tccgcctgaa gaaaagatta tgaaggatga 1513921 actgattgca cagcttgcgg aaaaaattca cgaactctct gaaaaagaac agctggttgt 1513981 cagtttgttc tacaaagagg agttgacact gacagaaatc ggacaagtat taaatctttc 1514041 tacgtcccgc atatctcaga tccattcaaa ggcattattt aaattaaaga atctgctgga 1514101 aaaagtgata caataatgaa tttcatggtt agcgagtgaa aaacatgtca acactattat 1514161 ggcttttaag ctttatgctc cacggcgttc ttctgtacgc tgtcattatc ctgtatacga 1514221 ggctcgctgc agtgaaagaa acagaaaaac agcaaaaaca gatacttgaa gagacggaaa 1514281 acaccttggc ggcatttctg cttgaattaa aagaagaaaa tgagaaactg atagaaaata 1514341 aagcttcatc tgcaagtcaa tcagatgaag aatcccaaaa gtcaggcctt cagacctctg 1514401 aaacatatca agagcgggat ccagtccaag aggcagagaa tcttcctgaa catattgaag 1514461 gtctgattac agaggttgac cgtcgggaag agctcgtaaa cagtgaggtc caatcatttg 1514521 aagaccaggt catagaatta tatgaacagg gatattcggc aagtcaaatt gcccagaaaa 1514581 tgaagagcgg aaagacagaa atcgagctat ttttaaaatt tcgctccaaa ggtgtaaagg 1514641 attcttgatt gtcggataaa gctgtgttat attatgtctt ggtgttaaat acacacgctt 1514701 aacgatttat gcagagggtg ctgcaggcgg cagttctgta caaaaatgac ctaagcggag 1514761 gaaaaaaacc attatattag gaggaaataa catgtcagtc atttctatga agcaattgct 1514821 tgaagctggt gttcacttcg gtcaccaaac acgccgttgg aacccaaaaa tgaagcgtta 1514881 cattttcacg gagcgtaacg gaatctacat cattgacctt caaaaaacag tcaaaaaagt 1514941 agaggaagct tacaacttca ctaaaaatct tgctgctgaa ggcggaaaaa tccttttcgt 1515001 cggaacaaaa aaacaagctc aagattctgt taaagaagaa gctcaacgct ctggcatgta 1515061 ctatgtcaac caacgctggt tgggcggtac attaacaaac ttcgaaacaa tccaaaaacg 1515121 tattaaacgt cttaaagaca ttgaaaaaat gcaagaaaac ggtacgtttg atgtacttcc 1515181 taaaaaagaa gtcgttcaat tgaaaaaaga attagagcgt cttgaaaaat tcctaggcgg 1515241 aattaaagat atgaaggatc ttcctgatgc attattcatc atcgatcctc gcaaagagcg 1515301 catcgctgtt gcggaagctc gcaaattaaa catccctatc atcggtatcg tagatactaa 1515361 ctgtgatcca gatgaaatcg atgttgttat cccagcgaac gatgacgcta tccgcgctgt 1515421 taaacttcta acttctaaaa tggcagatgc aatcttagaa gcgaagcaag gcgaagaaga 1515481 agcggaagtt gctgaagaaa ctgcaccaga aacagaaaca acaactgcgt aacctattca 1515541 aaaggtgata agagggactg ccttttatca ccttttttca agaaaaatgt gtaatataca 1515601 tactcttgtt taaacatata aggaggaata caaatggcaa ttactgcaca gcaagtaaaa 1515661 gaactgcgtg aaaaaactgg cgcgggcatg atggattgta aaaaagcgtt aactgaaact 1515721 gacggagata tggacaaagc aattgacctt ttaagagaaa aaggaattgc aaaagcagcg 1515781 aaaaaagctg accgtatcgc agcagaaggt tctactctta ttaaaactga cggcaacaaa 1515841 ggcgttatcc tagaagtaaa ctctgaaact gatttcgttg cgaaaaacga aggttttaaa 1515901 gagcttctta acactttagc tgaccacctt cttgcaaaca cgccagctga tgttgaagaa 1515961 gcaatgggcc aaaaaatgga aaatggctca actgttgaag agtacatcac aagcgcagtt 1516021 gctaaaatcg gtgagaaaat cactcttcgc cgctttacag ttcttacaaa agacgacagc 1516081 tctgcattcg gtgcgtacct tcacatgggc ggccgcatcg gtgtattaac tgttctcaac 1516141 ggtacaactg atgaagaaac tgcgaaagat atcgcaatgc acgttgctgc agttaaccct 1516201 cgttacattt ctcgtgatca agtatctgaa gaagaaacaa atcatgagcg tcaaatctta 1516261 actcagcaag ccctccaaga aggcaaacct gaaaacatcg tagcgaaaat ggttgaaggc 1516321 cgtctgaaca aattcttcga agaaatttgt ctattagacc aagcgttcgt taaaaaccca 1516381 gatgaaaaag tgaaacaagt tattgcagcg aaaaacgcta ctgttcaaac ttttgtccgc 1516441 tatgaagttg gagaaggcat cgaaaaacgt caagaaaact ttgctgaaga agtaatgaac 1516501 caagtgaaaa aataatggtg aaaagatttc gcggctaagt cgcgtctttt caggcagtat 1516561 aggggacaca ttttgtgttc cctattttta aaactatatt tacaaacctt tttttctctt 1516621 gcataataga aaacggcaat gtttacactt ggaggttatc atggaaaaac caaaatacaa 1516681 acgtatcgta ttaaagctta gcggggaagc attggcagga gaacagggaa atggaattaa 1516741 cccgactgtc attcaatcca ttgcaaagca agtgaaggaa atcgctgagc ttgaagtcga 1516801 agtggctgtt gttgtaggcg gcggcaactt atggcgcgga aaaacaggaa gtgacctggg 1516861 catggaccgc gcgactgctg actatatggg aatgctggcg acagtaatga attcgcttgc 1516921 tcttcaagac agcttggaaa cactcggaat ccagtccaga gtgcaaacat ccattgaaat 1516981 gagacaagtt gctgaaccgt acataagaag aaaagcgata cgccacttag agaaaaaacg 1517041 tgtcgttatt ttcgctgcgg gcacaggaaa cccatatttc tcaactgata cgacagctgc 1517101 actgcgggct gctgaaattg aggcagacgt tattttaatg gctaaaaata acgttgacgg 1517161 tgtgtataat gctgatccta gaaaagatga atcagctgtt aagtatgaat cactttctta 1517221 tcttgacgtt cttaaagacg gcctggaagt catggattca acagcttcct ctttatgcat 1517281 ggacaatgac attccgctta tcgtcttttc tattatggaa gaaggaaata tcaaacgtgc 1517341 cgttatcggt gaatcaatcg gaacgatcgt gagggggaaa taacgtgtca aaagaagtat 1517401 taactcaaac aaaagaaaaa atggaaaaag caattgctgc ttatcagcgc gaattggcta 1517461 ctgtacgcgc aggccgtgca aatccatcat tattagataa agtaacggtt gaatattacg 1517521 gagcgcagac acctttaaat cagttgtctt ctattaacgt gcctgaagct cgtatgctcg 1517581 ttatcacgcc atacgataaa acagcaatcg gtgatatcga aaaagcgatt ttaaaagctg 1517641 atttaggtct tacaccaaca agtgacggca atatgattcg aattgcaatt ccggcactaa 1517701 cagaagagag acggaaagaa ttagtgaaag ttgtaaaaaa atatgctgaa gaagcaaaag 1517761 tagctgttcg taacgttcgc cgtgatgcta acgatgatct caaaaaactt gagaaaaacg 1517821 gagacattac tgaggatgaa ctgcgtgctt ccactgaaga cgttcaaaaa ctgacagatg 1517881 aatatgtgtc aaaaattgac agtgtcacaa aagacaaaga aaaagaaatc atggaagttt 1517941 aatgaaaaac tatgtacaat agataatagt gaaaagaccc tctcatgttt acagggggtt 1518001 tttttgttaa tactgttgat tacattgatt atcagcaggg aatgtaacct ttttgggtga 1518061 cggaggaatc tcatgctcaa catactcaaa aattggaaga atcagcaaac tgcggcttcc 1518121 aacttagaac gttatacaaa agaagacata cttaagggag aaattcccga acacatcgcc 1518181 attatcatgg atggaaatgg ccgttgggct aaaaaacgct ctcttcccag aattgcaggc 1518241 caccatgaag ggatgaaggt ggtaaaaagg accacgaagc tcgcaaacga attaggtgtc 1518301 aaagtactga cattgtatgc attttcaaca gaaaactgga aaagaccgaa aatggaggtc 1518361 gattttttaa tgaagcttcc ggaagaattt ttgaatacgt atcttccaga gcttgttgag 1518421 gaaaatgtac aggttcggat cattggggat gaaacggctt tgccggcgca cacattacgt 1518481 gcgattgaaa aagctgtaca ggacacggcg caaaacgacg gaatgatcct taattttgct 1518541 cttaactatg gaggccgtac tgaaattgtc agtgctgcaa aatcactcgc ggaaaaagtg 1518601 aaggaaggct ctttgaatat tgaagacatt gatgaatcgc ttttttctac ttatttgatg 1518661 actgaatctt tgcaggatcc tgaactttta attcgaacga gcggcgagat aaggctgagt 1518721 aattttatgc tatggcaggt tgcctacagt gaatttgtct ttactgacgt cttgtggcct 1518781 gactttaaag aagatcactt cttgcaggcg ttaggagagt ttcagcagag aggccggagg 1518841 tttggcggaa tttagaggat ggtggacatg aaacaaagaa ttttgacagg tgttctggca 1518901 gcaattgtat ttttattttt ggttattgtc gggaaattgc cgttcaccat attaatttat 1518961 gctatgggca gtgtggcgct ttttgaactt ttacggatga aaaagctgaa gctggtttca 1519021 ctgccgggtt tgatcggtct tttattattg tggatgttct tattaccaag ccagtattcg 1519081 ttttttgaag cggacgggat ttccaaaatg gaaatcgctt tatttgcggt actgctattg 1519141 ctgacttaca cagtgttggt caagaacacc tttacttttg atgaagtcgg gtttattacg 1519201 cttgcagcaa tttacatcgg aatgtgtttt cattatttta tcgaaatcag aaatcttgac 1519261 caatacggat taacatacat tttttatgcg tgtgttgtca tttggtccac cgattccggt 1519321 gcctattttg tcggtaaatc gcttgggaag cggaaactgt ggcctgaaat cagtccgaat 1519381 aaaacagtgg aagggtttgc aggcggaatt gtcatcgcac ttgtattggc gacgattttt 1519441 cagcttgttg cacaacttcc gatcccgtat atctatctgc tgttgatcac gctgtttttg 1519501 tctgtttttg gacaactggg agatttagtg gaatccgcct tgaaaagaca ttacgatgta 1519561 aaggattctg ggaatattct tcccgggcat ggcggtatat tagaccgttt tgacagtttc 1519621 ttgtttgtca tgcctttctt gtactttctg cttgcccttt tttcataaaa aagtctaata 1519681 tgaatatgag actgatcatg cagcaataag aataggagta gtggcaactt tgaaaaatat 1519741 ttgtctttta ggagcaacag gatcaatcgg cgaacagact cttgatgtac tgcgtgcaca 1519801 tcaagaccaa tttcagctgg tatctatgtc gtttggcaga aatattgata aggccgttcc 1519861 aatgattgag gtctttcagc cgaagtttgt ctctgtcggt gatctggata catatcataa 1519921 attaaaacaa atgtcttttt cttttgaatg ccaaatcggg ctgggagaag aaggactgat 1519981 agaagcagca gtgatggagg aggttgacat tgttgtcaac gctttgcttg gaagcgtcgg 1520041 tcttatcccg acattaaagg caattgaaca gaaaaaaaca attgcgcttg caaataagga 1520101 aactcttgtc actgcagggc atatagtaaa agaacatgct aagaaatatg atgttccgct 1520161 gctgcctgtt gacagtgagc attcagccat ttttcaagct cttcaaggcg aacaggctaa 1520221 aaacattgaa cgcctcatca ttacggcatc cggcggaagt tttcgggaca agacgcggga 1520281 ggagctcgaa tcagtaacgg ttgaagatgc attaaaacat ccaaactggt caatgggtgc 1520341 aaaaattaca attgattcgg ctacaatgat gaataaggga ttagaggtga tcgaggcaca 1520401 ctggcttttc gatatacctt atgaacaaat tgatgtggtt ttacataagg agagcatcat 1520461 ccattcaatg gttgagttcc atgataaaag tgtgatcgca cagctcggaa ctccggatat 1520521 gagagtcccc attcaatatg cgctcactta tcctgaccga ttgccattac cagatgcgaa 1520581 aaggcttgaa ttatgggaaa tcggcagcct tcattttgag aaagctgatt ttgacaggtt 1520641 ccgatgctta caatttgctt ttgaatcagg taaaatagga ggaacaatgc cgacagtgct 1520701 aaatgcggca aacgaagtag ctgtcgctgc ctttttagct ggcaagatac cgtttttggc 1520761 tattgaagac tgtatcgaaa aggcactaac ccgccatcaa ttactgaaaa aaccgagcct 1520821 ggcggacatt caagaagtgg acaaagatac ccggggatac gtcaattcaa tactcacata 1520881 aggtggtatg ttcgtgaata cagttatagc gtttatcatt attttcggaa cgctcgtttt 1520941 cttccatgaa ctgggccatt tattgctagc ccaaagagcg ggaattctct gccgtgaatt 1521001 tgcgatcggc ttcggtccaa agattttttc tttcaaaaaa aatgaaacag tttatacgat 1521061 caggctgctt ccggtcggcg gatttgttcg tatggccggc gaagatccgg aaatgattga 1521121 ggtgaaaccc ggatacacgg tcgggcttct gtttaataag gaagatcaag ttgagaaagt 1521181 catcatcaat caaaaggaaa aatatccgga tgctttagtc attgaagtgg aaacagcgga 1521241 tctagagcat gacatgaaga tcaccggtta tgaacagggg aaagaggacg aactttccag 1521301 ctttactgtc agcgaaacat ccttttttat tgtagacgga gaagaagtgc agattgcgcc 1521361 gtataatcgc caatttggtt ccaaacctgt atggcagcgg attaaagcaa ttgctgcagg 1521421 gccgattatg aactttattt tagcttacgt cattttagtg atgcttgggc tgattcaagg 1521481 cgtaccgtca aatgaaccta tgctcgggca gctgacagac aatggacggg cggctgaagc 1521541 agggctaaaa gaaggggatt atatccaaag cattaacgga gagaaaatga ggtcttggac 1521601 tgacattgtc tccgctgtaa aagaaaaccc ggagaaagaa atggacgttg cagtaaaaag 1521661 agataacaaa acgcttcata tttcggtgac tccggaagct gttaaagatg agaacaaaaa 1521721 aacaatcgga cgtttcggtt cctatgcgcc gactgaaaaa ggcgtactct cagcggttgc 1521781 ttacggcgcg acatcaacag ttgatgtcac caaagccatt ttaaccaatc tgagcaaatt 1521841 agtaacaggc caatttaaac tcgatatgct gtcaggtcct gtcggcatat atgacatgac 1521901 agaccaagtg gcgaaaacag ggatcgtgaa cttatttcag tttgcggcgt ttttaagcat 1521961 taaccttggg attgtcaacc tgcttccgat tccggcactt gacggaggaa gactgttgtt 1522021 tctatttatt gaagcgattc ggggcaaacc gattaacagg gaaaaagaag catttgttgt 1522081 gtttatcgga gtagctttct taatgcttct tatgctggtt gtcacatgga acgatatcca 1522141 gcggctgttt ttgtaaacga aaagtaaatc aatcagaggt gcgaagaaat gagacaaagc 1522201 ttgacgctta ttcctacgct ccgtgaagtt ccagctgatg ccgaagcaaa aagtcatcag 1522261 cttcttctga gagcaggatt tatcagacag aatacgagcg gggtatacag ctatatgcct 1522321 cttgcgtata aggtgattca aaacattcag cagattgttc gagaggaaat ggagaaaatt 1522381 gatgccgtag aaatgctcat gcccgcattg cagcaggcag agacatggca ggaatcaggc 1522441 agatggtata cgtatggtcc cgaactgatg agactaaaag accgtcatgg ccgtgaattt 1522501 gctttagggg caacgcatga agaggttatc acttcgcttg ttcgcgatga ggttaaatct 1522561 tataagcgtc tccctctgac tctttatcaa attcagtcta agttcagaga tgaaaaacgt 1522621 cctcgcttcg gtttgttaag aggccgcgaa tttattatga aggatgcgta ctctttccat 1522681 gcatctgcag agagcctgga tgaaacgtat caaaaaatgt acgaggccta ttctaatatt 1522741 tttgcccgct gcggcattaa tgtaagacct gttatcgctg attcaggcgc aatgggagga 1522801 aaggatacgc acgaatttat ggcactttct gcgatcggag aggatacgat tgcgtattct 1522861 gatgaatcac agtacgcggc taatatcgag atggctgaag ttcttcacca ggaagttcct 1522921 tcagatgaag agcctaaagc tctagagaag gttcatacgc ctaacgtgaa aacaatcgaa 1522981 gaactgactg cgttcttaca ggtttcggct gaagcgtgca ttaagtcagt attgtttaaa 1523041 gctgatgacc gttttgtctt agtgcttgta agaggggatc atgaagttaa cgatattaaa 1523101 gtgaaaaact tgcttcatgc agaagttgta gagcttgcta cacatgaaga ggtcattcag 1523161 cagctcggaa cagagccagg ctttgtaggc cctgtcggta ttcatcagga tgtggaagta 1523221 tatgccgatc aagctgtgaa agcaatggtt aatgctgttg ccggggcaaa tgaaggagat 1523281 catcattata aaaatgtcaa tgtgaatcgt gacgcgcaaa ttaaagaatt tgctgatctt 1523341 cgttttatta aagaaggtga tccttcacca gacggcaagg gaacgatccg ttttgctgag 1523401 ggaatcgaag tcggacaagt ctttaagctc ggaacacgct attcagaagc gatgaatgcg 1523461 acatatttag atgaaaacgg acgcgcgcag ccaatgctga tgggctgtta cggaatcggt 1523521 gtgtcaagaa cgctttctgc tattgctgaa cagcatcacg acgaaaaagg cttaatatgg 1523581 ccaaaaagcg ttgcgccgta cgatcttcat attcttgctt tgaacatgaa aaacgatggg 1523641 caaagagagc ttgctgaaaa gctgtatgcc gatttaaaag cggaaggcta tgaagtgctc 1523701 tatgatgacc gtgctgagcg tgccggcgta aaattcgctg attcagattt aatcggcctt 1523761 ccaatccgca tcactgtcgg aaaacgagct gacgaaggaa tcgtcgaagt gaaaattcgt 1523821 caaactggtg agtcaactga gatttcagta gacgaattat ctgcgtttat cagcaagcag 1523881 taatcaccat aacgatttat caaaaaacat gttaaaatag aaataataga aggtacctca 1523941 ttgcctgagg taccttcact tatgatgttt ttagggaggg atactgtctt aatggaacag 1524001 ttatcagtaa acagaaggca gtttcaaatt cttctgcagc agattaatat gacagatgat 1524061 accttcatga catactttga acatggcgag attaaaaagc tgacaattca caaagcttct 1524121 aagtcttggc attttcattt tcaatttaaa tctttgctgc cttttcaaat atatgacaca 1524181 ttaacaacga ggctgacgca atcgtttgcc cacatagcaa aagtgacatc ttcaattgaa 1524241 gttcaggatg ccgaggtcag tgaaagtatc gttcaagact actggtcacg ctgcattgaa 1524301 gaactgcagg gcatttcgcc gccgattatc agtcttttaa accagcaaaa accgaagctg 1524361 aagggcaata aactgattgt caaaaccaaa acagatacag aagcggctgc gctaaagaac 1524421 aaatacagtt ccatgattca agcagaatac cgtcaatttg gctttccgga tcttcagctt 1524481 gatgctgaaa tatttgtatc cgagcaagaa gttcaaaagt ttcgggagca aaagcttgcg 1524541 gaagaccaag agcgggctat gcaggccttg attgaaatgg agaagaaaga taaagaaagt 1524601 gatgaagacc aagcaccatc tggtcctctt gttatcggtt atcaaattaa agataacgag 1524661 gaaatccgaa cacttgacag catcatggac gaagaacgga gaattacggt ccaaggttat 1524721 gtgtttgatg tggagacgcg cgagctgaag agcgggcgca cgctgtgtat cttcaaaatt 1524781 acagactata caaatagtat tttgatcaaa atgtttgcac gtgaaaaaga agatgcggcg 1524841 ctgatgaagt ctctgaaaaa aggaatgtgg gtaaaagcac gcggaagcat tcaaaatgat 1524901 acatttgtca gagaccttgt catgatcgca aatgacgtaa acgaaataaa agcaaaaacc 1524961 cgtgaagatt cagcacctga aggagaaaaa agagtggaat tgcatcttca ttccccaatg 1525021 agccaaatgg atgctgttac gggtatcgga aagcttgtcg aacaggcgaa aaaatggggg 1525081 catgaggcca tcgctttgac cgaccatgct gtcgttcaat ccttccctga tgcgtattct 1525141 gcggccaaaa agcatggaat taaaatgatt tacgggatgg aagcgaatct cgtggatgat 1525201 ggcgtgccaa ttgcttataa tgccgcacat cgtctgctcg aagaagaaac atatgttgtt 1525261 tttgacgttg agacgacagg attgtctgct gtatacgata ccattattga gctggctgca 1525321 gtaaaagtaa aaggcggaga aattattgat aaatttgagg cgtttgcgaa cccgcatcgt 1525381 ccgctttccg ccacaatcat agagctgaca gggatcacag atgatatgct acaagacgct 1525441 ccggatgtcg tagatgtaat aagagatttc agagaatgga ttggcgatga tattcttgtc 1525501 gctcataatg caagctttga tatgggattc ttaaatgtag cctataaaaa acttcttgaa 1525561 gtcgaaaaag ctaaaaaccc agtcattgat acgcttgaac ttggacgttt tctctatccg 1525621 gaatttaaga accaccggtt gaacacactt tgtaaaaagt ttgatatcga gctcacacag 1525681 catcaccgtg cgatctatga tactgaggca accgcttatt tgcttctgaa aatgctgaaa 1525741 gacgcagctg aaaaaggtat tcagtaccat gatgagttga atgaaaatat gggtcagtcc 1525801 aatgcttatc aaagatcaag accgtatcat gcaacattac ttgccgtgaa cagcacggga 1525861 cttaaaaatt tatttaagct tgtgtcactt tctcatattc attattttta cagagtgccg 1525921 cgtattccga gatctcagct tgagaaatac agggaagggc ttctgatcgg ttctgcttgt 1525981 gacaggggag aggtttttga gggaatgatg caaaaatcgc ctgaagaggt ggaagatatc 1526041 gcgtcattct atgattacct tgaggttcag ccgcctgaag tgtatcgtca cttgctggag 1526101 cttgaactgg tccgtgatga aaaagcgctg aaagaaatta ttgcgaatat cacgaagctg 1526161 ggggaaaagc ttaataaacc ggttgttgct acgggaaatg ttcattactt gaatgatgag 1526221 gataaaatct acagaaagat tttaatatcc tcacaaggcg gggcaaatcc gctgaatagg 1526281 catgaactgc cgaaagtgca tttcagaacg acagacgaaa tgcttgaagc tttttctttc 1526341 ttaggtgaag aaaaagcgaa ggagatcgta gtcaccaata cccaaaaggt tgcttcttta 1526401 gttgatgaca tcaagccgat taaagatgat ttatatacgc cgaaaatcga aggcgctgat 1526461 gaagagatca gagaaatgag ctatcagcgt gcaagaagca tttacgggga agagctgcct 1526521 gaaattgtcg aagcgcggat tgaaaaagag ttaaagagta ttattggcca cggatttgct 1526581 gttatttact tgatctctca caaacttgta aaacgttcac tagatgacgg gtatctcgtt 1526641 ggttcccgtg gttccgtagg atcttcatta gttgcgacac ttactgagat tactgaggta 1526701 aacccgctgc cgccgcacta tgtttgtcct gagtgccagc attctgagtt ctttaatgac 1526761 ggttctgtcg gttctggttt tgacctgcct gacaagacat gccctcattg cggaacgcct 1526821 ttgaaaaaag acggccatga tattccattt gaaacgttct taggatttaa aggggacaaa 1526881 gtacctgata tcgatttgaa cttctcaggg gaatatcagc cgcaagcaca caattacaca 1526941 aaagtattgt tcggagaaga caatgtatat cgtgcgggaa caataggcac ggtggcagaa 1527001 aaaacagcct acggttatgt aaaaggctat gccggagaca acaatcttca tatgcgcggt 1527061 gccgaaatag atcggctcgt acagggatgc acaggtgtaa aacgtacaac tggacagcac 1527121 cctggcggta ttatcgtagt tccggattat atggatattt atgatttttc accgatccag 1527181 ttcccggcag atgccacagg ttcagagtgg aaaacgactc attttgattt ccactccatc 1527241 catgacaacc tgttaaaact tgatattctc ggacacgatg acccgactgt tattcggatg 1527301 cttcaagact taagcggaat agatccgaaa acaattccga cggatgatcc tgaagtgatg 1527361 aagatcttcc agggaaccga atcactcggt gtgactgaag aacagattgg ctgtaaaacg 1527421 ggcactcttg gaattcctga attcggaacc cgatttgtcc ggcagatgct tgaagataca 1527481 aagccgacca ctttttctga gctcgttcag atttcaggct tgtctcacgg aactgatgta 1527541 tggcttggca atgcacagga gctcatccac aataatattt gtgagctgag tgaggttatc 1527601 ggctgccgtg atgacattat ggtttattta atctatcaag gccttgagcc gtcccttgcc 1527661 tttaaaatca tggaattcgt gcgtaaagga aaaggattaa cgcctgaatg ggaagaagaa 1527721 atgaaaaata acaatgtccc agactggtat attgattcct gtaaaaagat taaatacatg 1527781 ttcccgaaag cccacgccgc ggcatatgtc ttaatggcag tccgcattgc ttactttaaa 1527841 gtgcatcatg ctcttttgta ttatgcggct tattttaccg ttcgtgcaga tgactttgat 1527901 attgatacaa tgatcaaggg ctctacagca atcagagcgg taatggagga tataaacgct 1527961 aaaggacttg atgcttcacc gaaggaaaag aaccttctga ctgttttaga attagcgctt 1528021 gagatgtgtg agagaggcta ttcattccaa aaagtcgatt tatatcgctc cagcgccaca 1528081 gagtttatta ttgacggcaa cagtcttatt ccgccgttta actctattcc agggttaggg 1528141 acgaacgctg ctttgaacat tgtaaaagct cgcgaagaag gcgaattcct ctcaaaagaa 1528201 gatttgcaaa agagagggaa agtatcaaaa acgattttag agtacttaga tcgccatggc 1528261 tgtctggagt cactgcctga tcaaaaccaa ttgtcactgt tctaatatgg aaagcagaat 1528321 ttctcagaaa ttctgcttct atgcatacat aagcgcaaaa agtgccatcg taatattaga 1528381 gtttctgtca cttgcttagg tatgaaggta agcgtatatc catttgcaat aaaaatatgg 1528441 ttatggtata gttttattgg aaatgctaac gattaccgag gcaaagagtg gggaaacccg 1528501 ctcttttgta ttgaacagga gaattttgtc tcgacatgtt catcgtttac tttttagccc 1528561 ctgctctttt gaagcagggt ttttatgcag agtgacgaga cgaatatgag atcgacagca 1528621 caaggaggaa gaacatgagc aaaaaagtga ctgacaccgt tcaagaaatg gctcagccaa 1528681 tcgtagacag ccttcagctg gaactcgttg acattgaatt tgtcaaagag ggccaaagct 1528741 ggttccttcg cgtgtttatt gattccgatg acggtgtgga tattgaggaa tgtgccaaag 1528801 taagcgaagc tttaagcgaa aagcttgatg aggcagaccc aatcagccaa aattactttc 1528861 ttgaagtctc atctccagga gctgagcgtc cgctaaagaa aaaagccgat ttcgaaaaat 1528921 cactaggaaa aaacgtatac attaagacgt atgagcctat tgacggcgta aaagtgtttg 1528981 aaggtgaact ggctgaattt gatggacaaa cagtgacagt tgagatcacg atcaaaacaa 1529041 gaaagaaacg gatcaatatt ccgtatgaaa agatagctaa tgcaagatta gctgttacat 1529101 tctaatgaat acaaatgttt taagggggga gaccgttaaa tgagcagtga attattagat 1529161 gctctcacga ttcttgaaaa agaaaaaggc atcagtaaag aaattatcat cgaagcaatc 1529221 gaagctgcgt taatttctgc ttataagcgg aattttaatc aagcgcaaaa tgtacgggtg 1529281 gatctaaacc gtgaaactgg ctccatccgt gtatttgcaa gaaaagatgt cgttgacgaa 1529341 gtatacgacc agagattaga aatctcaatt gaagaggcac agggcatcca tccggaatat 1529401 atggtcggcg atgtcgtcga aatcgaagtt acacctaagg atttcgggcg catagctgct 1529461 caaacagcga agcaggtcgt cacacagcgt gtgcgcgaag ctgagcgcgg tgtgatttat 1529521 tctgaattta tcgaccgtga agaagacatc atgacaggga tcgtccagcg tctggacaat 1529581 aaatttatct acgtgtcttt aggcaaaata gaagccttgc tgccggttaa tgagcaaatg 1529641 ccgaatgaaa gctacaagcc ccatgaccgc attaaggtat atatcacaaa agtagaaaaa 1529701 acaacgaagg gtccgcagat ttatgtgtca agaacacatc caggcctgtt aaagcgtttg 1529761 tttgaaattg aagtgcctga aatttatgat ggaactgtcg agctaaaatc tgttgccaga 1529821 gaagccggcg accgttcgaa aatttctgtt cgcacagatg atcctgacgt tgatcctgtc 1529881 ggttcatgcg tagggcctaa aggccagcgt gtgcaagcaa tcgtcaatga attaaaaggt 1529941 gaaaaaattg acattgtcaa ctggtccagt gatcctgtag aatttgtcgc gaatgcgctc 1530001 agcccttcca aagtgcttga tgtcattgtt aatgaagaag aaaaagcgac aactgttatt 1530061 gttcctgatt accagctgtc tctggcaatt ggaaaaagag gacaaaacgc acgcttagct 1530121 gctaaactga caggctggaa gattgatatt aagagcgaaa cggacgcaag agaacttgga 1530181 atctatccga gagaacttga agaagatgat gagccgctct ttacggagcc tgaaactgct 1530241 gaatcggatg aataagaggt gactttaggt gaataaacac aaaaagatcc cattacgcaa 1530301 atgtgtagtg actggtgaaa tgaagcctaa aaaggaactg atccgagttg tacggtcgaa 1530361 agaaggcgaa atctcagtag acccgaccgg aaaaaagaat gggcggggtg cttatttaac 1530421 gctggataaa gagtgcatct tagcagcaaa aaagaaaaac actttgcaaa atcaatttca 1530481 atcacaaatc gatgaccaga ttttcgatga attgctggaa ctggcggaaa aggtgaaaaa 1530541 ataaaatgtc tggaatggaa tggtttccct tgctgggtct ggccaatcga gctcgtaagg 1530601 tcgtgtcagg cgaagacttg gtaataaaag aaatcaggaa tgcgcgtgca aagcttgtcc 1530661 tgcttacaga ggatgcatca tctaacacag caaaaaaagt aactgacaag tgcaattatt 1530721 ataaagtccc ttataaaaaa gtcgagagtc gcgcggttct tggacgctct atcggtaaag 1530781 aagcccgtgt cgttgtcgcc gtcactgacc aaggttttgc gaataagctg atcagcttgc 1530841 tcgattaata tttttggggg tgaacgaatg gctaaaatga gagtatacga atatgcaaaa 1530901 gcgttaaatg tttcaagtaa ggaaattttg accgcactga agaacatgga tttagaagtg 1530961 aataatcaca tggccatgct tgaagaaaag gccattaaaa agctagatgc caaatataaa 1531021 aaaggcggcg cagctgctaa atctcaaaag ccagcagaaa cgaacaaaaa caaacagcca 1531081 caaggggtta atcagcaatc agctggaaat caaccaaata aaattcgaga cggaaagaag 1531141 aatgacgtgc agaataatca atttaacaaa aacaagaaga ataacaacaa caaaaaaaat 1531201 aaacgcaaca acaacaataa taaaaaccaa catcagcaaa agcctgtaaa gccgaaaaaa 1531261 gagcttcctg agaaaattac attctctggc actttaacag ttggcgcact tgctgaagag 1531321 cttggcaaag agccttcaga actcattaaa aagctgatgc ttcttggcgt aatggcaacc 1531381 attaaccaag agcttgataa agacacaatc gaactcattg catcagaata tggtgttgaa 1531441 acagaagagg tcattgtgct tgaagaaaca gagctggaaa aatacgaaga gcctgataat 1531501 gaagaggatc ttgaaattcg tcctcctgtc gtgacaatca tgggccacgt tgaccatggg 1531561 aaaacaacgc ttcttgacag catccgtaaa acaaaggttg ttgaagggga agcaggcgga 1531621 atcactcagc atatcggcgc ttatcaaatt gaagagaacg gcaagaaaat cacgttcttg 1531681 gatacaccgg gccacgccgc atttacaaca atgcgcgcac gcggtgcaga agtaactgat 1531741 attacgattc ttgtcgtagc tgccgatgac ggtgtcatgc cgcaaacagt tgaagcgatt 1531801 aaccatgcaa aagcagcaga ggttccaatc atcgttgctg tgaataaaat agataaagaa 1531861 tccgcaaacc ctgaccgtgt aatgcaagaa ctgacggaat acggacttgt ccctgaagct 1531921 tggggcggag aaaccatttt tgtgccgctt tccgctttaa ctggaaaagg cattgatgag 1531981 ctcgttgaaa tgattttgct tgtcagtgag gtagaggaac tgaaagcgaa tccgaatcgt 1532041 caggcaaaag gaacggttat tgaagctgaa ctcgataaag gcagagggtc agtcgcgacg 1532101 ttgctcgtac agactggaac actgcatgtc ggtgatccga tcgtagtcgg caatacattt 1532161 ggccgtgtcc gtgcaatggt caacgacatt ggccgccgtg tgaaaactgc cggcccgtca 1532221 actccggttg aaattaccgg tttgaatgat gtccctcaag cgggagacca attccttgtc 1532281 tttaaggatg aaaaaacagc tcgttctgtc ggtgaagccc gtgcttcgaa acagcttgaa 1532341 gagcagcgca gcgataaagc gaagctcagt cttgatgatt tatttgagca aattaagcaa 1532401 ggtgatgtaa aagacatcaa cctcatcgta aaagctgacg ttcaaggatc tgctgaagct 1532461 ttaacggctg cacttcaaaa aattgaagta gaaggcgtta aagtgaaaat catccataca 1532521 ggcgttggtg cgattactga atcagacatt atcttggcat ctgcttccaa tgcaattgtt 1532581 atcgggttta atgtgagacc ggacggaaat gctaagagta cggctgaagc tgaaaatgta 1532641 gatattcgac ttcaccgtat catttacaaa gtaatcgacg agattgaagc tgccatgaaa 1532701 ggtatgcttg atcctgaata tgaagaaaaa gtaattggtc aagtagaagt acgccaaaca 1532761 ttcaaagtat ctaaaatcgg tacaattgcc ggcggatatg ttactgaagg aaccattacg 1532821 cgcgacagcg gcctccgttt aattcgtgac ggcgtcgtca tctttgaagg cgaagtagat 1532881 gttctgaaac gctttaaaga cgatgtgaaa gaagtttcac aaggctatga atgtggtatt 1532941 acaattaaga aatacaatga cattcgtgaa ggtgacatcc ttgaagcgtt tgtcatgcaa 1533001 gaaattgaaa gaacgtgatc ggatttgcgg agtgtgaatg catcatttat gatgcaggat 1533061 cgctaaaaga aaagcgtgcc gttctgaagc ggattttaac cagggttcaa aacaagttca 1533121 atgtttcgat ttcggagatt ggctatcagg acacctggca aagaaccagc ttcggaatcg 1533181 ccgctgtttc ttcctctcgc gttcaaacag aaaaagaact gcagcgcgtc ctagcgttta 1533241 tcgattcttt tcctgaaatt gaacggacga tcactaggac agagtggttt taacttagag 1533301 gtgattgaat tgagtatgag agcaaaccgt gtcggcgagc aaatgaaaaa agaactcggt 1533361 gatattatca gccgcaagct gaaagacccg agaattggtt ttctgacagt aacggatgta 1533421 cgtgtatcag gtgatttgca aattgcaaag gtgtatatct cggttctcgg tgacgagaaa 1533481 aaacgggaag aagcgctgaa agggctggca aaagcgaaag gatttatccg atccgaaatc 1533541 ggcagccgca tcagacttcg aaaaacgcct gaaattgaat ttgagttcga tgaatcaatc 1533601 gattacggga atcggatcga aacactgatt cacgaattac attcagagaa accatctgaa 1533661 taaaaaaaga gaggataggc gtatatcgtc tgtcctcttt cttcgtttat aagaaaaaaa 1533721 ctcaaaagaa ggagtgaaag gcaaatggtt aacggagttc tccttttaca taaacctgtt 1533781 ggcatgacat cgcacgactg tgtcatgaag atccgaaagc tgttaaaaac aaaaaaagta 1533841 ggacatacag gaacgctcga tccggaagta tcaggcgtgc ttccgatttg tgtaggaaga 1533901 gcgacaaaaa tagtcgaata cttaactgaa aaatctaaaa cgtatgatgc agaaataaca 1533961 ttgggctttt caaccacaac agaggatcaa accggagaaa cggtggaaac aaagcctgtc 1534021 aatcacgaca ttgataaagc ggatgtagaa aaggttttaa acagtttaaa ggggaaacaa 1534081 gaacaaattc cgcccatgta ttccgctgta aaagtaaacg gcaaaaaatt atacgaatac 1534141 gcaagagcag ggattgaagt agaacgtccg aaacgtatga taaccattga agacattgcc 1534201 ctgacaacag agattaaaca tcatggagaa accgcaagct tccggtttac agtgacttgc 1534261 tccaaaggga cctatgtaag gacgctggcg gtcatgatcg gagaaaagct cggatatccg 1534321 gcccatatgt ctcatttaat ccgtacggca tccggagatt tttctctcga cgaatgcttt 1534381 acttttgatg aactcgaagc acaggcccaa tccggaaccg tggaagagca tacagttcct 1534441 attgaacgtg cgctcaatca tttgccgaaa tggatcataa gtgatacatt agctaagaaa 1534501 gtagaaaatg gggctttgct tgagacgccc gagcagtttt ctgaaatgac aagtggagac 1534561 cgtattgccg tctttactga atccggaacc tgcttggcga tctatttccc tcatcctgca 1534621 aaaaaagggc tgttaaagcc ggcaaaagta ttgatgcaaa aaagcgaaca atagaaaaaa 1534681 ggtgaccgtt ctgtgaagac gatacatatt acacatcctc atcatttaat aaaagaggag 1534741 caggcaaaat cagtgatggc gttaggttat tttgacggcg ttcatctcgg gcatcaaaag 1534801 gtaatcggca cagcgaagca aatagccgaa gaaaaaggtc tgacattagc tgtgatgacc 1534861 tttcatcccc atccttctca cgtgttgggc agagataagg aaccaaagga tctgattacg 1534921 cctcttgaag acaaaataaa ccaaattgaa caattaggca cagaagttct gtatgtcgtt 1534981 aaatttaatg aagtgtttgc ttctctttct cctaagcagt ttatagacca gtatattatc 1535041 ggccttaatg tgcagcacgc agtggcaggc tttgacttta cgtacggcaa atacggcaag 1535101 ggaacaatga agaccatgcc ggatgattta gacggaaaag ctgggtgcac aatggtagaa 1535161 aaattaacgg agcaggataa aaaaatcagt tcttcgtata tccgtaccgc gcttcaaaac 1535221 ggagatgttg aattggcgaa tgtcttgctt ggacaacctt attttattaa aggaattgtc 1535281 attcatggtg ataaaagagg gcggaccatc gggtttccga cagcgaatgt cggtttaaat 1535341 aacagctata tcgttccgcc cacaggtgta tatgccgtaa aagcggaagt gaacggcgaa 1535401 gtttacaatg gcgtttgcaa tattggctat aagccaacgt tttatgaaaa gcgccctgaa 1535461 cagccttcca tcgaggtcaa tctgtttgat ttcaatcaag aggtatatgg agccgctata 1535521 aaaatcgaat ggtacaaacg gattcggagc gagcggaaat tcaatggcat caaagaatta 1535581 actgagcaaa ttgagaaaga taagcaggaa gccatccgtt atttcagcaa tttgcggaaa 1535641 taacttgcaa cgcacgcaaa ttttattcta aaatatttgc atataggcac gatttttagt 1535701 atgatagttt tcgtagtctt aaaaccattg cttggcaatc cgaagtcacc gacggttgct 1535761 aggtaactgg ggctaaatat gatttggagg tgaaacagga tggcaattac tcaagagcgt 1535821 aaaaaccaac tcatcaatga gttcaaaaca cacgaatctg atactggatc tccagaagtt 1535881 cagatcgcta tcctaactga ctcaattaac aacttgaacg agcatttacg tactcacaag 1535941 aaagaccacc actcacgtcg cggtcttctt aaaatggtag gtaagcgtcg taatcttctt 1536001 acgtatctgc gtaataaaga cgtaactcgt taccgtgagt taattaacaa actaggctta 1536061 cgtcgataat cgtaaaaagc gggaggattc ccgctttttt atcgtattaa agcgaaattt 1536121 cttataacaa atcattgaaa tccttttaca tactactttg acattgatat gttcaattca 1536181 tttcgttcat aataggagta attgattatt tcacacaacg aagagaggag ttcgtaattg 1536241 tatgggacaa gaaaaacatg tctttaccat agattgggcc ggaagaacgc ttaccgttga 1536301 aaccggccag cttgccaaac aggcaaatgg tgctgtgatg atccgctacg gtgatacagc 1536361 agtacttagt acagcaaccg cttcaaaaga acctaaaccg cttgatttct tccctcttac 1536421 tgtaaactat gaagaaagat tatatgcggt agggaaaatt ccgggcggat ttattaaaag 1536481 agaaggacgt ccaagtgaaa aagcggttct tgccagccgt ttaattgacc gtccgatccg 1536541 tcctttgttt gccgatggat tccgtaatga agttcaagtc atcagcattg tcatgagtgt 1536601 tgaccaaaac tgctcttcag aaatggctgc catgttcggt tcatctcttg cactttctgt 1536661 atcggatatt ccgtttgaag gaccgattgc aggggttact gtcggacgca ttgatgatca 1536721 atttatcatt aacccgacag tcgatcagct tgaaaaaagc gatatcaatc ttgtcgttgc 1536781 cggcacgaaa gatgcgatta acatggtaga agcgggagcg gacgaagttc ctgaggaaat 1536841 catgcttgag gccattatgt tcggccatga agagattaaa cgcctgattg cattccaaga 1536901 agaaattgtt gcagcagtcg gcaaagagaa atctgaaatt aagctctttg aaattgatga 1536961 agagcttaat gaaaaagtaa aagctttggc agaagaggat ctgctgaaag ccatccaagt 1537021 tcatgaaaag catgcccgtg aagatgccat taacgaagtg aagaacgcag ttgtggcaaa 1537081 attcgaggat gaagaacatg atgaagacac aatcaagcaa gtgaagcaga ttttatccaa 1537141 gcttgtgaaa aatgaagttc gccgcctgat tactgaagag aaagtaagac cggacggccg 1537201 cggtgtcgat caaatccgtc cgctctcttc agaggttggc ctcttgccaa gaacgcacgg 1537261 ttcaggtcta tttacaaggg gacaaactca ggccctcagc gtatgtacgc taggtgctct 1537321 gggagatgtg caaatccttg acggcttagg tgtcgaagag tcgaaacggt ttatgcatca 1537381 ttacaacttc ccgcaattca gcgttgggga aacaggaccg atgcgcggac cgggacgtcg 1537441 tgaaatcgga cacggagcac tgggtgagcg tgcgcttgag ccagttattc cgtctgaaaa 1537501 agacttccct tatactgtcc gtcttgtttc agaagtgctt gaatcaaacg gttctacatc 1537561 tcaagcaagc atttgcgcaa gcacacttgc aatgatggat gccggtgtac cgattaaagc 1537621 gccagttgct ggtattgcga tgggtcttgt caaatcaggc gaacattaca ctgtcttgac 1537681 tgacatccaa ggcatggaag acgcgctcgg agatatggac tttaaagtag cgggaactga 1537741 aaaaggcgta acggccctgc aaatggacat taaaattgaa ggcctttcca gagagattct 1537801 tgaagaagcg cttcagcagg cgaaaaaggg cagaatggaa atcctcaaca gcatgcttgc 1537861 aacattaagc gaatcaagaa aagagctttc tcgatatgcg cctaagatct taacaatgac 1537921 cattaatcct gataaaatcc gcgatgtcat cggaccaagc gggaaacaaa tcaataagat 1537981 catcgaagaa accggtgtta aaattgatat tgagcaggac ggcacaatct ttatttcctc 1538041 tacagatgaa agcggcaacc aaaaagcgaa aaaaatcatc gaagaccttg tgagagaggt 1538101 tgaagtcggc caactttacc taggtaaagt gaaacggatt gaaaaattcg gggctttcgt 1538161 tgaaattttc agcggaaaag acggtttggt gcacatttca gagcttgcgc ttgaacgcgt 1538221 agggaaagtt gaagatgttg tgaaaatcgg agacgagatt cttgtcaaag tcactgaaat 1538281 tgataaacaa ggacgagtga atttatcccg caaagcggtg ctccgtgaag agaaagaaaa 1538341 agaagaacaa caatcttaaa tgaaaacata aaaggagcct gggagacccg gcttctttat 1538401 tttgaagctt ttcaaaagca ggcgggttct accttgtcct tctccttcat aatgtgaggt 1538461 gaggggggga cagaacatgt acaaaaaatt tgtaccgttt gccgtttttt tatttctttt 1538521 ttttgtctca tttgagatga tggaaaatcc gcatgcactt gattatatag gggcaatgaa 1538581 aaaagatacg gtgactgtca cggcgtcaaa agacccgtta tatgaagaat tgcttcaaaa 1538641 agcgccggag tacgaagtta agccccagaa tgcaagaatt gataaagtgt ggaaaagcat 1538701 tccaggctac aatggattaa aggtcaatat tgaacaatca tataaaaaaa tgaaacagca 1538761 tggtaagttt cgggaaaaag atttggtgta cagtcaagta aaaccaagtg ttcatcttga 1538821 gtcacttcag cctgagccta tttataaagg aaatcctgac aaaccgatgg tggctttttt 1538881 aatcaatgtg gcatggggaa atgagtattt ggaaaaaatg cttcctattc tgcaaaagca 1538941 ccaggttaaa gctacgttct ttttagaagg caattgggtg agaaacaatg tacagctcgc 1539001 taagaagatt gcaaaagacg gacatgaaat cggaaatcat tcatacaatc atccggatat 1539061 gagcaaactg actacaggaa gaatttccga gcagctcgac aagactaatg aacaaataga 1539121 acaaacgatc ggcgttaagc caaagtggtt cgctccgcca agcggaagtt tcagaaaagc 1539181 ggttatcgac attgcagcag agaaacagat gggaacagtc atgtggacag ttgatacaat 1539241 cgattggcaa aagccggctc cgtctgtact tcagacgaga gtgttaagca agatacataa 1539301 tggtgccatg attttaatgc atccgactga ccctacggcg gaaagtcttg aagcgctgat 1539361 tacacagata aaagacaaag gatatgcgct tggaacagtc actgaactaa tggatgaaac 1539421 aagactattg aagtaacaga tgaaggcagc ttgtctttga ataggaggaa caaatttgat 1539481 taaacgatat acgtgtcaaa atggtgtaag aattgtgctg gaaaataacc cgacagtccg 1539541 ttctgttgcg atcggcgtat ggatcggcac aggttcgaga catgaaacgc cggagataaa 1539601 cggaatttct cactttttag agcacatgtt ctttaaaggg acgagcacaa aatctgcacg 1539661 cgagatagca gaatcttttg atcgtattgg cggccaggtc aatgcgttta cttcaaagga 1539721 atatacctgc tactatgcaa aggtgcttga cgagcatgcg aattacgcgc tggacgtatt 1539781 agcagatatg ttctttcatt caacgtttga tgaaaacgag ctgaaaaaag agaaaaatgt 1539841 agtatatgaa gaaattaaaa tgtatgaaga tgcgccggac gacattgtac atgatttatt 1539901 gagcaaagcc acttacggca atcattcttt aggctaccca attttaggaa cggaagaaac 1539961 gcttgcttcc tttaacggtg actctctcag acaatacatg catgattatt atacgccgga 1540021 ccgagtggtg atttcggtag cgggcaatat atctgacagt tttatcaaag atgtagaaaa 1540081 atggttcggg tcatacgagg cgaaaggcaa agcgacaggc cttgagaagc ctgagttcca 1540141 cacggaaaaa ctgacgagaa aaaaagaaac agagcaggct catttgtgcc ttggatttaa 1540201 aggcttagag gttggccatg aacgtattta tgatttaatc gtcctcaaca atgtgctcgg 1540261 aggcagcatg agcagccggc tgttccaaga tgtgcgtgaa gataaaggac ttgcttattc 1540321 tgtttacagc tatcacagct catatgagga cagcggaatg ctaacgattt acggcggaac 1540381 gggtgcaaat cagcttcagc agctgtcgga aacaattcaa gaaaccctgg ccacattaaa 1540441 acgtgacggc attacctcga aagaactgga aaacagcaaa gagcaaatga agggaagctt 1540501 aatgctgagc ttagaaagca caaacagcaa aatgagccga aacggaaaaa atgaactgct 1540561 gctcggcaaa cataaaacat tagatgaaat tatcaatgaa ttaaacgccg tgaacttaga 1540621 gcgtgttaat ggccttgcca gacaattgtt taccgaagac tatgcattag cacttatcag 1540681 cccttccggc aatatgccgt cttaaaaagg aaagcctgcc ccataatgga gcaggcattt 1540741 tttaatccct ttcatcatac atagtacaag ggggtgacag acatgcggct cagtgaatta 1540801 tcgggaaagg aaattgtaga catcaaaaga gctgaacggc tcggagtgct cggccagacc 1540861 gatttggaaa tcaatgaaca ggatggacag attacagcac tcctcattcc cacagttaag 1540921 tggtttggtt tgagaaagca aggtcatgac attcgtgtcc catggcacca tattcaaaag 1540981 atcggttcag atatgattat attagatgta cctgaggaaa tgcctcctcg acaagagtaa 1541041 atagcccaat tgactgtgaa gcgggctcta aagaaaacat ctgaaacatc ggctgccgga 1541101 gccgatgttt ttttatatgg aaaaagcgca tcttttatat tcaccggtat ttccttttga 1541161 tcataagatg aaggggagct taacaactag agatccagta tatacaaaga aggtgaacgt 1541221 ttagaatgtt aaccggattg aaaattgcag ttatcggcgg tgacgcaaga cagctcgaaa 1541281 ttataagaaa gctcactgaa cagcaggctg acatctatct tgtcggtttt gaccaattgg 1541341 atcacggttt taccggggca gtaaaatgca atattgatga aattcctttt cagcaaatag 1541401 acagcatcat tcttccagta tccgcgacaa caggagaagg tgtcgtatcg actgtatttt 1541461 cgaatgaaga agttgtgtta aaacaggacc atcttgacag aacgcctgca cattgtgtca 1541521 ttttctcagg aatttctaac gcctatttag aaaacattgc agctcaggca aaaagaaaac 1541581 ttgttaagct gtttgagcgg gatgacattg cgatatacaa ctctattccg acagtagaag 1541641 gaacgatcat gctggctatt cagcacacgg attatacgat acacggatca caggtggccg 1541701 ttctcggtct ggggcgcacc gggatgacga ttgcccgtac atttgccgcg ctcggggcga 1541761 atgtaaaagt gggggcaaga agttcagcgc atctggcacg tatcactgaa atggggctcg 1541821 ttccttttca taccgatgag ctgaaagagc atgtaaaaga tatagatatt tgcattaata 1541881 ccataccgag tatgatttta aatcaaacgg tactttctag catgacacca aaaaccttaa 1541941 tattggatct ggcctcacgt cccgggggaa cggattttaa atatgccgag aaacaaggga 1542001 ttaaagcact tcttgctccc gggcttccag ggattgtcgc tcctaaaaca gctgggcaaa 1542061 tccttgcaaa cgtcttgagc aagcttttgg ctgaaataca agctgaggag gggaaataag 1542121 gatgtcgtca ttaaaaggaa aaagaatcgg gtttgggctg accgggtcgc attgcacata 1542181 tgaagcggtt ttcccgcaaa ttgaggagtt ggtcaacgaa ggagctgaag tccgtccggt 1542241 tgtcacattt aatgtaaaat ctacaaatac ccgatttgga gagggcgcag aatgggttaa 1542301 aaaaattgaa gacctgactg gatatgaggc cattgattcg attgtaaagg cagaacctct 1542361 tgggccgaag ctgccccttg actgcatggt cattgcgcct ttaacaggca attcaatgag 1542421 caagctggca aatgccatga cggacagccc ggtgctgatg gcggcaaaag cgacaatccg 1542481 gaacaatcgg cctgtcgttc tgggtatctc gacaaatgat gctcttggtt taaacggaac 1542541 aaatttaatg aggctcatgt caacaaaaaa tatctttttt attccattcg ggcaagatga 1542601 tccatttaaa aaaccgaatt caatggtagc caaaatggat ctgcttccgc aaacgattga 1542661 aaaggcactc atgcaccagc agcttcagcc gattctagtt gagaattatc agggaaatga 1542721 ctaaatttac agaaaatctt tcccaaacta aaaaattcgg tcatcacccg catattctat 1542781 ggtaaaataa aacgtaaaat catagtcaaa tcaattcaat gaagctgatt ggcggaagga 1542841 gttttacaga tgggaagagg tttacacgta gctgttgtcg gagcgacagg ggctgtggga 1542901 caacaaatgc ttaaaacact tgaagacaga aactttgaaa tggacacact tacattgcta 1542961 tcttcaaaac gctctgcggg gacaaaagtc acgtttaaag gccaagagct gactgttcag 1543021 gaagcttctc ctgagagctt tgaaggggta aatattgctt tgttcagcgc cggcggaagc 1543081 gtatcacaag cattggcacc agaagctgta aaacgcggcg ctattgttat agataatacg 1543141 agtgcgttcc gcatggatga aaatacaccg cttgttgtgc cagaagtgaa tgaggcagac 1543201 ttgcatgaac acaacggcat tattgccaat ccaaactgct ctacaatcca aatggttgcg 1543261 gcacttgaac cgatccgcaa agcatatggc ttaaacaagg tcatcgtatc aacttaccag 1543321 gcagtatcag gagcgggtaa tgaagctgta aaagagcttt acagccaaac acaggcgatt 1543381 ttaaataaag aagaaataga gcctgagatc atgcctgtaa aaggtgacaa aaaacactat 1543441 caaatcgcct tcaacgcgat tccgcaaatc gataaattcc aagataacgg ctatacgttt 1543501 gaggaaatga aaatgataaa tgaaacgaaa aaaatcatgc acatgcctga ccttcaagta 1543561 gcggctacat gtgtgagact gccaatccaa actgggcact cagagtccgt ctacatcgaa 1543621 atagaccgtg atgacgctac agttgaagat attaaaaatc tattgaaaga agctccgggc 1543681 gtgacacttc aggatgatcc aagccagcag ctttatccga tgcctgctga tgctgtcggc 1543741 aaaaacgatg tgtttgtagg ccgcatccgc aaagacttgg acagagcaaa cggttttcat 1543801 ttatgggttg tttctgataa cctattaaaa ggcgcggcat ggaactctgt tcaaattgca 1543861 gaaagcctga aaaaactaaa cctcgtataa aagagagaat tttctaaaga cgaatagaag 1543921 agagtaaggc gctatcagcc tgctctcttc tgttacgtcc gaataatttg gagtgaaaac 1543981 agtgaagata attgttcaaa agttcggcgg aacatcagta aaagatgata aaggccgcaa 1544041 actggcttta gggcatatta aagaagcaat cagtgaagga tataaggttg tcgttgtcgt 1544101 ttcagcgatg ggccgaaaag gggacccgta tgcaacagat tctttgctcg ggctgcttta 1544161 cggcgatcag tcagcgattt ctcctaggga gcaggatttg cttttatctt gcggagagac 1544221 tatttcctct gtcgtcttta caagcatgct gcttgataac ggtgtgaaag cagctgcgct 1544281 gacaggggct caggctggct ttttaacgaa tgatcagcat actaatgcga aaatcattga 1544341 aatgaaaccg gagcgtttat tcagtgtgct cgccaatcat gatgcggtag tcgtcgcagg 1544401 cttccagggc gcaactgaaa agggtgatac aacaacaatc ggcagagggg gcagcgatac 1544461 gtctgcagcc gcactcggag cagctgttga tgcggaatac atcgatattt tcaccgatgt 1544521 agaaggcgtg atgactgctg acccaagagt ggtagaaaat gcaaaaccgc ttcctgttgt 1544581 gacgtatacg gaaatctgca acctggcgta tcagggggcc aaggtcattt ctccgcgtgc 1544641 tgtggaaatc gcaatgcagg ccaaggttcc gatccgcgtc cgttcgactt attcgaatga 1544701 taaaggcaca ttggtgacat cacatcactc ttccaaggtc ggcagtgatg tttttgaaag 1544761 gctgattacg ggaatcgccc atgtcaaaga tgtcacgcag ttcaaagtgc ctgcgaaaat 1544821 cggccagtat aacgttcaga ctgaagtgtt caaggctatg gcaaacgctg gaatcagtgt 1544881 cgatttcttt aacattacac ctagtgaaat cgtctatacg gtagccggaa ataaaacaga 1544941 aacagctcag cgtattttaa tggatatggg ctatgatcca atggtgacga gaaactgcgc 1545001 gaaggtatcg gcggtcggcg cgggcattat gggtgttccc ggtgttacgt ccaaaattgt 1545061 atcggctctt tcagaaaaag aaattccgat ccttcagtcg gctgacagcc atacgacgat 1545121 atgggtgctc gtccatgaag cggatatggt tcctgctgta aacgctttgc atgaagtgtt 1545181 tgaactttcg aagtaaatgt gattgaatca tgatgaggtg aataaaatga atttcggaaa 1545241 tgtgtctaca gcgatgatta caccctttga caataaaggg aacgtagact ttcaaaaact 1545301 gtctacactg attgattact tgttgaaaaa cggaacggat tctttagtag tagcgggaac 1545361 aactggagaa tctccgaccc tttcaactga agaaaaaatt gcgctttttg aatatacggt 1545421 aaaagaagta aacggacggg tgcccgttat cgctggtact gggagcaaca acacgaaaga 1545481 ttccattaag ctgacaaaaa aagctgagga agcgggcgtg gacgctgtta tgcttgttac 1545541 cccgtattac aataaacctt ctcaagaagg aatgtaccag cattttaaag caattgcggc 1545601 agagacatct cttccggtta tgctctataa tgttcctggc cgtacggttg cttctcttgc 1545661 tcctgaaacg acgatccgtt tggcggcaga cattccgaat gtggttgcga ttaaagaagc 1545721 gagcggagac ctcgaagcga ttacaaaaat tattgctgaa acacctgaag acttctatgt 1545781 ctattcaggg gatgatgctc taacgcttcc aattctttca gttggaggta gaggagttgt 1545841 gtcagtggcg agccatattg caggcactga tatgcagcaa atgatcaaaa attatacgaa 1545901 tgggcaaaca gctaatgcgg cactgattca tcagaaactg ctgccgatta tgaaggaact 1545961 gtttaaagcg cctaatcctg ctccagtcaa aacagcgctt cagctgagag gtcttgatgt 1546021 cggttctgtg cgtctgcctc tagtcccatt aactgaggat gaacgtctga gcttaagcag 1546081 cacgatcagc gaactgtaag aaaatttcat acagtgaaac aaacgcggtc attctcacat 1546141 tcagctgagt ttgaccgttt cttttacata ttggttttcc ctaaaccttc tgctttatct 1546201 tgttttctaa atttactttc agttataata ggaacaagtg atgatggacg ggtatgagac 1546261 taggaggata tagattttga aaaagaaaaa tacagaaaac gttagaatta tcgcccttgg 1546321 cggtgtcgga gagattggga agaaccttta tgtcattgaa attgactcag acatatttgt 1546381 cgttgatgcc ggccttatgc atccagaaaa cgaaatgctc ggtattgatg tagtgattcc 1546441 tgacatatca tatttgattg aacgggctga ccgcgtcaag gcaatctttt taacgcacgg 1546501 gcacgatgaa aatatcggcg gcgtttttta cttattaaac aagctgtccg ttccagtgta 1546561 cggaacaaaa ctgacgcttg cactgttaag agagaaatta aaacaatacg gacataaccg 1546621 aaaaactgat ttaagagaaa ttcactccaa atctgtcatt acatttgaat caacaaaggt 1546681 atcgttcttt agaacgattc acagcattcc tgattctgta ggtgtgagct ttaaaacatc 1546741 acttggatct attgtatgca cgggagactt caaatttgac caaacacctg cacttaatca 1546801 gacgtgcgac attggcgaga tcgccaagat cggcaatagc ggcgtgctcg ctctgctttc 1546861 tgacagtgca aatgcggaac ggccgggtta caccccttcg gaagcggctg tcagcggaga 1546921 aatttcggat gcgctgtata attcacagaa ccgggtgatt attgctgttt tcgcatccaa 1546981 tattaaccgg attcagcaag tcattcatgc agcggctcaa aatggcagaa agattgccgt 1547041 agccggaaaa aatcttcaat ctgtcctgca gctggcgaga aagttaggat atattgaagc 1547101 agatgatgaa ttgtttattt ctgtacagga tgtcaaaaaa tatccgaagc gcgaagtggc 1547161 cattattaca gccggaagcc aaggtgaacc attagctgct ttgacaagaa tggcaaacaa 1547221 agctcacaaa cagctgaaca ttgaagaagg ggatacggtg gtcattgcgt caactccgat 1547281 tcccgggcag gaactcattt actctaaaac agtagatctt cttgcgagag ccggtgcaca 1547341 agtcatcttt gcccaaaagc gtgttcatgt atcaggccac ggctcacaag aagagttaaa 1547401 gctgatgatc aacctgctta aaccaaaata tttgattcct gtaaacggcg aatacagaat 1547461 gcaaaaagct cattcaaaaa tcgctgaaga aaccggcatg aagcgcagtg acatcttctt 1547521 aattgaaaaa ggcgacgtcg ttgaattccg cggccaaaac gtaaaaattg gggataaagt 1547581 tccttacggc aatattttaa ttgatggttt aggtgtcggt gatatcggca atatcgtatt 1547641 gagagaccgc cgcttgcttt cacaggacgg aattttaatc gttgtcatta cacttgataa 1547701 acaaaagaaa catcttgtat caggaccaga aattatcact cgcggctttg tttatgtaag 1547761 agagtctgaa ggtcttatcg tacaggctac tgagcttgta cggtccatcg tgacagaagc 1547821 gactgaaaca tcaaatgtcg aatggtcaac gctgaagcag gcaatgcggg atgctttgaa 1547881 ccaattcctt tatgaaaaaa cgaaacgtaa accgatgatc atcccaatta ttatggaagt 1547941 ataatgactg actaaagacc ggagctgctc cggtctttat tttttgtcct tcaagccggg 1548001 attgaatgaa gtatctttgt tcataataca aagagaaact cggaaaggat gaaagcgaga 1548061 tggatcatcg tatggaaaac acagaagaag agcgtcctga aaaaaatgat gcgaaggaca 1548121 gcattatgaa taaaatacag cagcttggtg aaacgacgct tccgcagctg ccccaagata 1548181 caaatattca ttgtctgacc attatcggac aaattgaagg ccatgttcag cttcctccgc 1548241 aaaacaaaac aacaaaatat gaacatgtca tcccgcagat tgtggcaatt gaacaaaatc 1548301 ccaaaattga aggcttgctg atcatattaa atactgtcgg aggagatgtt gaagctggtc 1548361 ttgccatagc ggaaatgctt gcatctttat cgaaaccgac cgtttctatc gtgcttggcg 1548421 gggggcattc aatcggcgtt ccgattgctg tatcctgtga ttacagctat atcgccgaaa 1548481 cagcaacgat gacgattcat ccagttaggc tcaccgggct ggtcatcggg gtgccgcaaa 1548541 cgtttgaata cctggataag atgcaagaaa gagttgttaa atttgtgaca agccattcca 1548601 atataaccga agagaagttt aaagagctaa tgttttcaaa aggaaactta acacgcgata 1548661 tcggaacaaa tgtagtcggt aaggatgcag ttaaatacgg attgatcgat cacgcaggcg 1548721 gtgtcggaca ggcaatcaat aaactgaatg agctcatcga tgaagcaagg aaagaagaag 1548781 gacggatgat tcaatgattc tttataccgt gatgcctcag gaaattgtgt ttgcagaaca 1548841 gaaccaagag acaagcgcac atgagcaaat tgaatataaa ggtgtaccgc ttctagtcga 1548901 aatgaaaggg aatgaagcgg aagtcattca aatcatgagc accaatccaa tgcattttct 1548961 gcatccggac atttcaccgg gacaaaagct gaaattaaac gtataagaat ccaacccttt 1549021 tttaagggca aaatatgcta taatagggga atcctacaga aaaaacgcag cctgtaaacg 1549081 gctgctttct tcattatgta tgaacttaca ttttttaacg cagtaaggtg atgagtgtgg 1549141 caaagaaaaa acgaaaatca agaaaaaaac aggcgaaaca gctcaatata aaatacgagc 1549201 tcaacggatt gctgtgtata gccatttcaa ttatcgcaat cttgcagctg ggggtagtcg 1549261 ggcaaacgtt tatctatttg ttccgctttt ttgctggaga gtggtttatt ttatgcttgt 1549321 taggtttatt ggtgttagga gtctcactgt tttggaagaa aaaaacccca agccttttaa 1549381 cgagacgaaa ggccgggttg tactgtatta tcgcaagcat attgctgctt tctcacgtgc 1549441 agctatttaa aaatttgacg cacaaagggt ctattgagtc tgcaagcgtg gtgcgcaata 1549501 cgtgggaatt gtttttaatg gacatgaatg gcagctctgc ttcacctgat ttaggcggag 1549561 ggatgatcgg tgcgctgctg tttgcggctt cacacttttt gtttgcgtcg actggttctc 1549621 agatcatggc aattgtcatg attttgatcg gaatgatttt agtaacagga cgctcgctgc 1549681 aagaaacgct aaaaaagtgg atgagcccga ttggacgttt tataaaagaa caatggttag 1549741 catttattga tgacatgaaa tccttcaaat caaatatgca gtcatcgaaa aaaacgaaag 1549801 cgccgagcaa aaaacaaaaa ccggcccgca aaaaacagca aatggaaccg gagcctcctg 1549861 atgaagaggg ggattatgaa acagtatcgc ctcttattca ttcagagccg attatctcaa 1549921 gcttttctga tcgtaatgaa gaggaagagt ctccagttat agaaaagcgc gccgaacctg 1549981 tgtcgaagcc gcttcaggac atccaaccgg agacaggtga tcaggaaact gtttctgctc 1550041 ctcctatgac ctttacagag ctcgaaaata aggattacga gatgccgtca ctggatttgc 1550101 tggcagatcc gaagcatacc ggccagcagg ctgataaaaa gaatatttat gaaaatgcga 1550161 gaaagcttga acgcacattc caaagctttg gcgtaaaggc gaaagtcaca caggttcatc 1550221 tcggaccggc cgtaacaaaa tatgaagtat atcctgatgt cggagtgaag gttagcaaaa 1550281 ttgtcaattt aagcgatgat ttagcgcttg cgcttgctgc gaaggatatc aggatcgaag 1550341 cgcctatacc aggcaaatca gcaatcggaa ttgaagttcc aaacgcagaa gtggcaatgg 1550401 tttcgctgaa agaagtgctg gagtctaaat tgaatgacag accggatgcg aagctgttaa 1550461 ttggactcgg ccgcaatatt tcaggtgaag ctgtattggc tgagttaaac aagatgcccc 1550521 accttttggt cgcaggcgca accggtagcg ggaaaagtgt ctgtgtcaac ggcattatta 1550581 caagtatttt aatgcgggcg aaaccgcatg aagtgaaaat gatgatgatc gatcctaaaa 1550641 tggtagagct aaatgtctac aacgggattc cgcatttgct tgctcctgtt gtaaccgatc 1550701 cgaaaaaagc gtcgcaggct ttgaaaaagg ttgtcaatga aatggagcgg cggtacgaat 1550761 tattttctca tacgggtaca agaaatattg aaggatacaa tgattatata aaacgcgcca 1550821 acaatgaaga aggagcgaaa cagccagagc tgccttatat tgttgtcatt gtggacgagc 1550881 tagccgatct catgatggtc gcttcatctg atgtggaaga ttcgattacg agattgtccc 1550941 aaatggcgcg ggctgccggc atccatctta ttattgcgac acagcggcca tcggtggatg 1551001 ttatcacagg ggtgatcaaa gcgaacattc cgtcacgaat cgcgttcagc gtatcttcac 1551061 agacggattc aaggaccatt cttgacatgg gtggcgctga gaagcttctt ggccgcggcg 1551121 atatgctgtt tttacctgta ggggctaaca aacctgtccg tgtgcaggga gcatttttgt 1551181 cggatgacga agtggagaag gtcgtcgacc atgtgattac tcagcagaaa gcgcaatatc 1551241 aagaagaaat gattcctgag gagacgacgg aaactcattc cgaggttact gatgaacttt 1551301 atgatgaagc tgttgaatta atcgtcggca tgcagacggc atctgtttca atgctgcaaa 1551361 gaagattcag aattggctat acgagagcgg cgcgcctgat tgacgcaatg gaggaacgcg 1551421 gtgttgtcgg accgtatgaa ggcagcaaac ctagggaagt attattatca aaagagaaat 1551481 atgatgagct ctcttcttaa tgaagggagt tccgctttct atagttgtca ataatgatat 1551541 tatgtaaact gatcaccttt ctatttattt tttcgacaaa acatgatata gttgtcccaa 1551601 ttgttcaata atttttatcg aaagtggttt acggagggga aacatgtcta caaaagctga 1551661 taatcggcac ttgtatttga aagtaattga acgaattaaa gaggatataa aaaatgggat 1551721 ctacactgag aaggaaaagc tgccttctga atttgagctt tccaaaaagc ttggtgtcag 1551781 cagagcgacg ctaagagaag ccttgcggat actggaagaa gagcatgtga ttatcagaag 1551841 gcatggtgta ggcacttttg tccattctaa gccgttattt ctttcgggta ttgaacagct 1551901 gaacagtgta accaagatga tagaacaggc gaatatgacc cctggcacga tttttctatc 1551961 atcacaagtg cttatgccgt ctgaagatga tacgaagaga tttcacttgg cagaagggca 1552021 agaacttttt taccttgaac gagtcaggac agctgacgga cagccgattg tgtattgtat 1552081 agacaaaatt ccgatgaata ttttgccgaa ttctttttct catcagcaag aatctatgtt 1552141 tgacctgcta gagaaaaatt caggctccgt aatcagctat gcagtaactg atatagaacc 1552201 gatcggctat cacgatacca tttctccagt gcttgaatgc gatccggaaa cagctctttt 1552261 gctgttaaaa caaacccatt acgatcagca cgataaaccg gtgctttatt ctttaaatta 1552321 ttttagagcg gataaattca gatttcatgt tttgcgtaaa cgattctaaa aacggacgcc 1552381 tgtatgtgtc tgttttttta tttgcactga ttcatgtttc tttgtacata ctttcattcc 1552441 ggttaacgca atatataagg gatgacaaga aagtgaatgg gtgaaaatgt tgagagagaa 1552501 aaatggaatg aaaaatatta ttgcattgtc ttctgtcccg cttgtgatga cactcgggaa 1552561 ctccatgctg attcctgttc ttccgatgat ggagaaaaag ctgtctgtga cttcatttca 1552621 agtatcttta atcattactg tatattcagt agtagcaatt atttgcattc cgattgccgg 1552681 atatttgtcg gatcgtttcg ggagaaaaaa aatattgctt ccatgcctcc tcattgcagg 1552741 attgggggga gccgtagctg cttttgcctc gacctatatg aaaaatcctt atgctatgat 1552801 cttggcgggg cgggttcttc aaggcattgg ttctgcaggt gccgctccga ttgtcatgcc 1552861 gtttatcggc gacctgttta aaggagacga tgaaaaggtc agcgcgggtc ttggcgatat 1552921 tgaaaccgcc aacacgtcag ggaaggtact gagtcccata cttggagcct tactggcttc 1552981 ttggtattgg tttgtaccgt tttggtttat tccgtttttc tgtttgatca gctttttgct 1553041 cgtattgttt ttggtggcca agcctgaaga agatgaagat gcgcctgctg tttctgagtt 1553101 tattaagagt gtgaagaaaa tttttaaaca ggatggtcgc tggctttata cggtcttcat 1553161 tatcgggtgt gtcattatgt ttttgttatt tggcgtatta ttttatttat cagatacgct 1553221 ggagaacaag tatgctattg acggagtagc taaaggcgga ttactggcaa tcccactttt 1553281 gtttttgtca accagttctt ttatagctgg caaaaagatc ggtaaagata aaggccgaat 1553341 gaaattttgc gttgttacag gaatgattct gttaaccctt tcgtttattg ccttgtggtg 1553401 gaaccacagt ttttattttt tatttgtctt tttaagcttt ggcgggattg ggattggaat 1553461 ggctcttcct gctttagatg cattgataac cgaagggatt gaaagtgaac aatgcggaac 1553521 catttcctcc ttttacaata gcatgcgctt tataggagta gctctcggtc cacctgtttt 1553581 tgctgcatta atgtctaatg caaactggat tattttcata ctctcggcgt tttgcagcat 1553641 cgtttcttta tttttagtgc tctttactgt agatgctaaa aaaagtgaag aagaaaaaaa 1553701 cttagggacg gtctagccag ccgtcttttt ttgcgctttc ttgcacagtt tacaactgta 1553761 cctatacagc atgcggaggt tattgtttcc ttataaatcc tacagttgct ataattacat 1553821 gaaagagtgt ttctgcggat gctgaaaatt ggtcataata catactaatt aagaaatgaa 1553881 cgaaggaggt tccatatgtc atatgttaat gaactcaaat caaagcacgg cggtttaacc 1553941 gcacacattg taaaaacaga aaaattcaaa accgtctcgc ttatttttaa gatgcttgcg 1554001 ccgctgacaa aggatcaagt caccaaaaga gcgcttctcc cgcatgtgct tcttcgcgga 1554061 acgaaaagcc atccgaaaac cgcaggattg cgttcatact tggatgagct gtacggcacg 1554121 tcagtatcgg ctgatcttac gaaaaaagga gagcggcatg tcattacgtt caggcttgaa 1554181 atcccgaatg aaaaatattt aaaagaccaa acgccgcttc tcgagaaagg gctccagctt 1554241 ctcgcagaac tcgtcttttc acctgctttg gagggagacg cttttcagtc acaatatgtg 1554301 gctcaagaaa aacggacgct taagcaaaga atccaagccg tctatgatga taaaatgcgt 1554361 tattcgaatt taaggctgat acaggaaatg tgcaaaaatg atccttacgc gcttcatgtc 1554421 aatggtgaaa tcgacgatgt cgatgacatt acggcagagc aattatacga aacataccaa 1554481 agcgctatcc aaaaagacca gcttgatcta tatgttgttg gcgacgtgga cagtaaccag 1554541 gtacaatcgg caattgataa gtatttcaaa acagaagagc gcactcttgg catgattgaa 1554601 aacaatcacg ctgatgaaaa agttcagcca aaagaagtaa ttgatgaaga ggatgtcaag 1554661 caaggaaaac tgaatatcgg ctaccgcacc agcatcactt atacagatca ggattatcct 1554721 gctttacaag tgtttaacgg attgttcggc ggattctctc attctaaact tttcattaat 1554781 gttcgggaaa aagccagtct tgcttactac gcggcttcgc gtatagaaag ttttaaaggc 1554841 ttgttaatgg tgatgtcagg cattgaagtg aaaaattttg aacaggcggt ttcgattatt 1554901 gctgagcaat tccaggcaat gaaaaatggc gatttcagtg agcaggatat agcacagaca 1554961 aaggccgtta ttcgaaatca agtgctggaa acgattgata cagcatacgg tttatctgag 1555021 tttttatatc agcaggccgc tgctcaagtc gagattccta tcgaagactt tcttgccaat 1555081 attgagaatg tcacaaaaga ggatatcatt aaagccggcg aaaagattca gcttgatacg 1555141 acttatttct taaaagggac ggagggtgca tcttgatcaa accaatcgaa tatgaacagc 1555201 ttcaggagac gctgtatcat gaaaaaatgt ccaacggcct tgatgtttac gttttgccga 1555261 aaaaaggctt caacaagaca tatgcggtct ttacaacaaa gtacggctcg atagataacc 1555321 ggtttgtccc tttaggtaaa aacgagatgg ttcacgtgcc ggacgggatt gctcactttc 1555381 ttgagcacaa gctgtttgag aaagcggacg gagacgtttt tcaagatttc agcaaacagg 1555441 gggcttctgc caatgcgttt acgtcattta caagaacggc ttaccttttc tcaagcacat 1555501 caaatgttga acgcaattta gagacgctta tcgatttcgt acaggaccca tattttactg 1555561 aaaaaacggt tgaaaaggaa aaagggatta tcgggcagga gattaatatg tacgacgata 1555621 accctgattg gaggctttac ttcggggtca ttgaaaacat gtacaaagag catcctgtca 1555681 gaattgacat agcgggaaca gtggaaagca tttcacatat tacaaaagac cttctttatg 1555741 aatgctatga aacgttttat cacccgagta acatgctcct tttcattgtc ggccctgtag 1555801 atcctgaagc gattatttct caggtaagag aaaaccaggg gaaaaagccg tatactgatc 1555861 agccggagat caaacgagaa gaagtgaaag agcaagaagc ggttttccga aaagaaaaag 1555921 agatcaaaat gaacgtgcag ggaccgaaat gccttgttgg gctgaaatcc aaaaatccgt 1555981 ttaaattagg caaagagctc ttaaagcatg aactttcaat gaacttattg cttgaagctc 1556041 tttttggcaa aagctctgcc cagtatgaat cactttatga aaaaggatat attgacgaaa 1556101 cgttcagctt tgattttact gctgaatatg ggttcggttt tgcggcgatc ggcggagata 1556161 cgcctgagcc tgatcaattg gctgaagaca tttcaagcat gcttttgcgc gccggtgaac 1556221 tgattactgc tgaaaagatt gaacttgcca gaaagaaaaa gatcggcaca ttcttaaaag 1556281 cgctgaattc ccctgaatac atcgccaatc aatttacccg ttatgcgttc ttggatatga 1556341 gcctgtttga tgttgtaacg gtactcgagc agattaccct cgaggatgtc cagaacgtaa 1556401 tacaagagga aatcgctgca gacagactga ctgtctgcaa ggttgttcct aaatcataaa 1556461 caaaacatcc ctccagtgtg aggggtgttt ttctgcggaa agaaggaaag aggatgaaca 1556521 aaacagcact aatcaccgga gcaagcggcg gcattggcaa aagcatcagc gaaacccttg 1556581 cagctagagg atacaatctg ctgctgcatt acaatacaaa tcaaaacgcg gcagcggagc 1556641 ttgctgaaaa actaagtcag atgtttggcg taaatgcgga gatattacaa gctgacctgt 1556701 ccgcgcaaga tggagcagat aagctgacaa gttcaattgt tcagccgatt gatgcgattg 1556761 ttttaaacag cggacgaagc cattttgggc tgattacgga tgtagataac gcaacggtcc 1556821 aggaaatggt tcagcttcat gtggcgagtc cgtatatgct gacgagaaac cttctgccag 1556881 gcatgattcg gaataaatcg ggagcgattg tggctgtcag ctcgatttgg ggagagactg 1556941 gagcatcctg tgaagtgttg tacagcatgg caaaaggagc tcagcattca tttgtaaaag 1557001 gattggctaa ggagctggcg ccaagcggaa tcagagtaaa cgccgtagcg ccgggtgcag 1557061 ttgatacaaa tatgatgaat caatttaccc cggctgaaaa agaagagatc gctgatgaga 1557121 ttccgatcgg ccggctggcc cggccgcaag aaattgcgga tgcaacagct tttctcctgt 1557181 ctgaaaaagc gtcatatatc accggccaaa ttctgtcggt gaatggcggc tggcactgct 1557241 gatccgaaaa tattcggtgt atagtttctt ttgcgaagga cacaataatc ttgtaacttc 1557301 acatgaaatg gaggaaacaa gcatgtcagt attagaaaac tgggatagct ggaaaaactt 1557361 ccttggcgac cgtctgaact atgcgcaaga taaaggtatg agccaggata cgattacaga 1557421 tcttgcgaca gaaatcggca gctacttggc taatgaagtg gaatctaaga acgagcagga 1557481 aaaagtgctg gcagatcttt ggagtgtagc atcaaaagat gaacagcacg ccattgccaa 1557541 tatgatggtt aagcttgttg aaaataacag cactcactag gaagagaggg gatttttcct 1557601 ctctttttta tgttttcctc atcacagcaa cattcttctt tctaattaga gaaaaatgct 1557661 ttatgataaa ggaaggtaaa attttgccac aatgaagggg gtatatcatt tggcaaagct 1557721 cgaatggtat tttgaatatg aaattcaagt gaaccgcccc ggactgctcg gggatatttc 1557781 atctcttctt gggatgcttt ctatcaacat cgtaacgata aacggcgtcg atctttccag 1557841 aaggggaatg ctcctcaggt gccgccatat agatcaaatt aaacgattag aatcaatctt 1557901 aaaaacgatg gaaacaatta aagtaacgaa gcttagagaa ccgaggcttc gcgaccgtct 1557961 tgccgtacgc cacggccgtt atattcaacg ggatgccgat gacaagaaaa cgttccgctt 1558021 tgaacgggac gagcttggct tattagtcga ttttatggcc gaattgttca aaaaagaagg 1558081 ccataaatta atcggaatca gaggtatgcc gcgtgtcggg aaaacggaat cgattgtagc 1558141 ctctagtgtg tgcgagcaaa aggtggctgt ttgtgtcatc aaccttgctg aagcagacga 1558201 taagaagcca gctgattgcc gatgaataca gcactgaaaa tgtctttatc gttgacggaa 1558261 ttgtgtcaac acgaagaggg tcagaacgcc atctccagct ggtccgagaa atcatgcggc 1558321 tgcctgcaac aaaagtggtg gagcatccgg acatattcgt tcaaaataca gagtatacac 1558381 tagatgactt tgattatatt attgaactga gaaatgaccc tgatgaggtt attacatatg 1558441 aacatgccga ggaaccccaa atgtttgatc aatccgggtt ttcaagcttt gatttttaaa 1558501 attggaaggt gtttgttgtg actgaactag gaatccggct caaagaagcc agagaggaaa 1558561 aagcaatgtc attggatgat ctccaagcgg caacaaagat tcaaaaaagg tatttaaccg 1558621 ccttggagga aggaaactat gacattattc cggggaagtt ttatgttcgg gcattcatca 1558681 agcaatatgc agaagccgtt gggcttgatg cggatcagct gtttgaggag cataaaaaag 1558741 atatccctaa tacgtatcat gatgatgtgt ctgaaaagat ctccggcatg aatcttcaaa 1558801 aggaaatgcc aaagccagca tctaaggcgc tggagctgct gccaacaata cttgttattc 1558861 tcggcgtgat tgtcgtgatt gccattgtgt acgcgatcat tcaatttgcc aatcacaaaa 1558921 acagtgatga tcacaatgcg gcatcagaaa aagcaattac gcaaagtgag agcaagtacg 1558981 aaatccctaa agattcaacg ctgaaagaga atcaaaataa cagctctgaa aaagagacag 1559041 acactaaaaa agaaacgaaa gaaaacgaag ataagaaaaa agaaaatgac agtgagaagc 1559101 tggagattaa agctgctggc actgaaggat cgttaacgac ttatgaagtg tccggcgctg 1559161 ataaaatcga gctggaactg aaggcatcag acagctcctg gattagagtg cgcgatgaaa 1559221 acagcagctc tttaaaagaa ggaacgctga aaaaagacga aacctataaa aaagacataa 1559281 ctgatcagaa acaagttgat atccgcaccg gatatgcacc taatctgaaa ataaaaatca 1559341 acggtaaggt tctttcatat gaacttgatc cgaaaaaagt gatggcacaa accataaaga 1559401 ttgtaaataa aaaggaagaa aagtcatctt aattaccaga tgacttttct tcacgtccga 1559461 gtatgaaatt ggaggggctt tatgtttaac ttaccaaata aaatcacact agctagaatc 1559521 gcattaatcc caatcttcat gattatcatg ctggcgccgt ttgactgggg caggctcgaa 1559581 gttggagacg aatccatccc ggtcgcacat ttggcggggg ccattctatt tattattgca 1559641 tctacaacag actgggtgga cgggtattat gcccgaaaat taaatctcgt aacaaacttc 1559701 gggaaatttc ttgatccgct tgcggacaaa ctgctcgtat ccgcagcgtt aattatcctt 1559761 gttcaatttg atctcgctcc agcttggatg gtcattgtga ttatcagcag ggagtttgcc 1559821 gtgacaggtt taaggcttgt cttagccgga acaggagaag tcgtagctgc taacatgctt 1559881 ggtaaaatca aaacctgggc acagattatt gcggtatctg cattgcttct tcataatctt 1559941 ccatttgaac ttgtgtcatt cccgtttgca gacttggcgc tgtgggtagc cgtcttcttt 1560001 actgtcgtct caggctggga atatttctct aaaaattggg aagcgttaaa aacatctaac 1560061 taagaaagaa ggacttcgtc atggaatttc caaaaaaagc agaaataatt gcagtcggtt 1560121 cagagttgct gcttggtcaa atcgccaata caaatgctca atttatcagc aaacagctcg 1560181 ctgaaatcgg ggtcaacgta ttttatcata cagcggtcgg agataacccg gagcggctga 1560241 agcaggtcat ccgcattgct gaagaacgct ctgacttcat tattttttca ggagggcttg 1560301 gacccacaaa agatgatctg acgaaagaaa cgattgcaaa tacgctggga cgtccgcttg 1560361 tgttaaatga tgaggcattc caatccattg aggactattt caaacgaaca aaacgcacga 1560421 tgtcacctaa taaccgaaaa caggcgcttg tgatcgaagg ctctgacgtg ctggcgaatc 1560481 actttggaat ggccccggga atgctcacag agcatgaatc gcgctattat atgcttcttc 1560541 ctggaccgcc gagcgaattg cgtccaatgt ttgaaaacga ggcaaagcct cttctgctga 1560601 aaaagatggg ttcaaatgaa aaaattgtgt caactgttct tcgctttttc ggtatcggtg 1560661 aatctcagct tgaagccgat ttggaagata ttattgatgc acaaaccaat ccgacaattg 1560721 cgcctttggc ggctgatgga gaggtgacgc tgcgtctgac agccaaacac gccgatgaaa 1560781 aggaaacaga gcgtctgtta aaagaaacag aggccgttat cttagagcgt gtcggtgaat 1560841 ttttctatgg ttacgatgat acttctcttg taaaagagct atctatagca tgtaaggaaa 1560901 aaggcataac aatttctgcg gcagaaagct ttaccggagg gctgttttct gaatggctga 1560961 cggatcatag cggtgcctca aaattatttg ccgggggcgt tgtttgctat acaaacgacg 1561021 tgaagcagaa tgtgcttggt gtcaagaagg aaacattaga tcgttttggg gcggtcagca 1561081 aggagtgcgc atccgaactg gctaagggtg ttcaaaaact cactggcagc gatatcggca 1561141 ttagctttac tggtgtagca ggacctgatg ctcaagaagg gcatgagcct gggcatgtgt 1561201 ttatcggcat ttccgcaaat ggtaaagaag aggttcacga gtttcacttt gcgggctcca 1561261 gaacggggat cagaaaacgc ggcgctaaat acggctgcca tttaatctta aagcttttag 1561321 agcaaaaata atattttcag cacattatcc tcctaagaaa acatgatttc tctgatacat 1561381 tatgatattt tgataggaat cacgccaaga aaaaatccga atatgcgttc gcttttttct 1561441 tggcaaatcc cttcaaacag ggtatagtat atgtagtggt aacataaagg aggaaaaaat 1561501 agaatgagtg atcgtcaggc agccttagat atggctctta aacaaataga aaaacagttc 1561561 ggcaaaggtt ccattatgaa actgggagaa aagacagata caagaatttc tactgtacca 1561621 agcggctccc tcgctcttga tacagcactg ggaattggcg gatatcctcg cggacggatt 1561681 attgaagtat acggtcctga aagctcaggt aaaacaactg tggcgcttca tgcgattgct 1561741 gaagttcagc agcagggcgg acaagccgcg tttatcgatg cggagcatgc gttagatccg 1561801 gtatacgcgc aaaagctcgg tgttaacatc gaagagcttt tactgtctca gcctgacaca 1561861 ggcgagcagg cgcttgaaat tgcggaagca ttggttcgaa gcggggcagt tgacattgtc 1561921 gttgtcgact ctgtagccgc tctcgttccg aaagcggaaa ttgaaggcga catgggagat 1561981 tcgcatgtcg gtttacaagc acgcttaatg tctcaagcgc ttcgtaagct ttcaggggcc 1562041 attaacaaat cgaagacaat cgcgattttc attaaccaaa ttcgtgaaaa agtcggtgtt 1562101 atgttcggga acccggaaac aacacctggc ggccgtgcgt tgaaattcta ttcttccgtg 1562161 cgtcttgaag tgcgccgtgc tgaacagctg aaacaaggca acgacgtaat ggggaacaaa 1562221 acgaaaatca aagtcgtgaa aaacaaggtg gctccgccgt tccgtacagc cgaggttgac 1562281 attatgtacg gagaaggcat ttcaaaagaa ggcgaaatca ttgatctagg aactgaactt 1562341 gatatcgtgc aaaaaagcgg ttcatggtac tcttatgaag aagagcgtct tggccaaggc 1562401 cgtgaaaatg caaaacaatt cctgaaagaa aataaagata tcatgctgat gatccaggag 1562461 caaattcgcg aacattacgg cttggataat aacggagtag tgcagcagca agctgaagag 1562521 acacaagaag aactcgaatt tgaagaataa aaataaaata agtttcaaat gatacaaaag 1562581 gctgagtgaa aaactcagct tttttgtatt ttgcaaaaaa atgataaaaa tattgctttt 1562641 tttgacaact tttttagggc tttattcgtc taacaaaacg tgtgcaaaat ggaatttatt 1562701 ttgggaggaa aaaatgaatg acaagcccaa cccgcagaag aactgcgaaa cgcagacgga 1562761 gaaaactaaa taaaagagga aaactgttgt ttggtctttt agcagtgatg gtttgcatta 1562821 cgatttggaa tgctcttcat cgaaatagtg aagaaaacga accatctcaa gaaactgcag 1562881 cggtttcaaa taccgatcag aaaaaagagg tcaaaaagaa aactgccaaa aaatcagagg 1562941 aacaaatcaa aacagtggat cgaaaccaaa aaatcagcaa ttatttaaaa gagatcggtt 1563001 tcagcggaac agccatgatt gtcagaaatg gagaaatcgt aacaaataaa ggttttggct 1563061 atgctgaccg taaacactac attcaaaata atccattgac atctttttat gtcggttcat 1563121 cacaaaaagc gctgattgca actgctattt tgcagcttga ggaaaagggg aaacttcaga 1563181 caagtgatcc ggtaagcacg tatttacctc attttcccaa cggacaaacg attactttga 1563241 agaatctgct tacacataca tcggggataa acggacatat tgaaggaaac ggcgccatta 1563301 ctccggacga tttaataaaa gatatagaac ttcagggaat caaacgtcag ccgggcgtat 1563361 gggactacaa ggattccaac tattctgttc ttgcttatat tattgctgaa gtaagcggtg 1563421 agccctatga acagtacata aagaatcata tttttaaacc tgcgggaatg acgcatgcag 1563481 gcttttacaa aacatatgaa aaagaacctt atcctgccgt cgggtataag atggagggca 1563541 gcaaaacagt tacaccgtat atacctgatt tatcccagct gtatggagcg ggtgatattt 1563601 atatgagcgc tatagatatg tacaaatttg accaagcgct gatagacgga aaactgtatt 1563661 cgcaaaaaag ctatgaaaag atgtttacgc cagggagcag ctccacatac ggcatgggat 1563721 tttatgttgc tcccggaagc tattcaaacc atggtgttat gccgggcttc aatatcttga 1563781 acagctttag caaatctggg caaaccattg ttattttgtt ctcaaacatt caaaataatg 1563841 ctaaattggg ccaagtgaac aataaaatat accagcttct aaatcaagaa tgattggcga 1563901 tcttcttttg gatgaattgc attcggcacg tgaaaagaag actggcctgc aaacgttaag 1563961 atggcaagct tgacaagtat ttccgacaca tttacaatga agttgtaaca tttgtttttt 1564021 taacatgatt gttaaaccat ttaaacttga caagggcgat gaacacactc attccctgtg 1564081 aaggttctgt atgttgagaa aactagacaa tgtacatgcc gacacttttt aagcaacaac 1564141 caagttcata gcaagaggag gtgaaagtat gaccccaatt atgatggttc tcatctccat 1564201 tttgctgatt ctactcggtt tagttgttgg ctactttgtt cgtaaaacca ttgccgaagc 1564261 gaaaattgcg ggcgcacgcg gtgcagccga gcaaattctt gaagatgcga agcgtgatgc 1564321 tgaagcactg aaaaaagaag ctctgcttga agcaaaggat gaaatccaca aacttcgaat 1564381 agatgctgaa caggaagttc gtgaaagacg aaatgagctt caaaaacaag aaaaccgttt 1564441 actccaaaag gaggaaaacc ttgatcgcaa acatgaggga attgataaac gggaagcgat 1564501 gttggagaag aaagatcatt ctctgaatga acgacaacaa catattgaag agatggaaag 1564561 caaagtggat gagatgattc gtatgcagca gtctgagttg gaacgaattt cgagtctgac 1564621 tcgtgacgaa gcgaaacaaa tcattcttga gcgggttgaa aacgagcttt cacatgacat 1564681 cgccatcatg acaaaagaaa ctgaaaaccg tgcgaaagaa gaggcggata agaaagcgaa 1564741 aaacattctt tcactcgcct tacagcgctg cgcagcggac cacgttgccg aaacaacggt 1564801 atcagttgtc aatcttccaa atgatgagat gaaaggacgt atcatcggac gggaagggcg 1564861 taacattcgt acgcttgaaa cgctgacagg aattgacctg attattgatg atacgcctga 1564921 agctgtcatt ctttccggat ttgatccgat cagacgtgag acagccagaa ttgctcttga 1564981 taaactcgtt caggatggcc gtattcatcc ggcacggatt gaagaaatgg ttgaaaaatc 1565041 tcgccgcgag gtcgatgact atattcgtga gatgggtgag caaacgacat ttgaggttgg 1565101 cgttcatggc ctccacccag atctcatcaa gatcctcggc cgcttaaagt tccgtacaag 1565161 ctacggtcaa aatgtgctta agcattccat ggaagtcgca ttcttggccg gtctaatggc 1565221 atcggagctt ggtgaagacg caaagcttgc taaacgtgcg ggtcttcttc acgacatcgg 1565281 gaaagcaatt gaccatgaag tagaaggaag ccacgttgag atcggggtag agcttgcgac 1565341 caaatataaa gagcacccag tcgtgattaa cagtattgca tcacaccacg gggacgagga 1565401 gccgacttcc attattgctg tactggtagc tgcagcagat gcgctttccg ctgcaagacc 1565461 tggcgcaaga agtgagacgc tcgagaatta tattcgaaga cttgaaaaac ttgaagaaat 1565521 ttctgagtcc tacgaaggtg ttgaaaaatc atttgccatt caggctggac gcgaagtgcg 1565581 aattatggtg aagccggatt caattaatga tcttgaggct catcgactgg cgcgagatat 1565641 ccgcaagcga attgaggacg agctcgatta tccaggtcat attaaggtga cagtaatcag 1565701 agagactcga gccgtagagt atgcaaaata aagtgatgcg ctaagcatca ctttattttt 1565761 ttgacggcaa ggaattttca agaagaaagg atttacaaaa tgagaatttt atttatcgga 1565821 gatgttgtcg gttcaccggg ccgtgacatg gtcaaagaat atgtaccaaa gctaaaaaca 1565881 aaatataagc ctcactttac cattattaat ggtgaaaacg ccgcacatgg aaaaggcctg 1565941 acggaaaaaa tttatcacag cttaatccag tccggcgcag atgcaatcac aatggggaac 1566001 cacacatggg acaaaaaaga aatatttgat tttatagatg acgttccgaa cttggttcgc 1566061 ccggcaaact ttcctgaagg aacaccgggg aaagggatca catatgtgaa agcaaacggc 1566121 aaagaactag cagtcattaa tttgcaggga cgtacgtttt tgccgccgct tgatgacccg 1566181 tttttaaaag cggatgaatt gatcgcagaa gctgcgaaaa gaacaccgta catttttatt 1566241 gactttcatg ccgaagcgac aagtgaaaag ctcgcacttg gctggtacac ggatggacgg 1566301 gcatcggctg tagtaggaac tcatacacac gtgcaaacag cggataaccg cattttgccg 1566361 aagggaacgg catatattac tgatgtggga atgactggcc cgtatgacgg tatactgggg 1566421 atggacagag agacgattat taagcgattc aaaacgaacc ttccagtccg gtttactgtc 1566481 gctgaaggaa aaacaacgct cagcggagtt gtcattgaca ttgacgatca aacgaaaaaa 1566541 gccgtgaaaa ttgagcgtat tttaatcaac gatgatcaca tgttctttga atagttgaac 1566601 atatggttat tttataaaaa tattaaaaag aaaagcagga atatagcaac tccttagtga 1566661 atatagtaaa aatggaaggt agcccgctat ttttgaaaag cattgtgggg atggcttttt 1566721 ggatagcaac atctaataat gattgttcta atgaacactc acttatccat tgtaaaacta 1566781 agggggagca gaaatggaaa tcttaaaagt ttcagcaaaa tcgagtccaa attcagtggc 1566841 aggtgcgctt gcaggcgtgt tgagagagcg aggagccgcc gagattcaag cgatcggagc 1566901 gggtgcatta aaccaggctg taaaagctgt ggcgattgcc aggggatttg tggcgccaag 1566961 cggcgttgat ttgatttgta ttccggcttt tacagatatt caaatcgatg gggaagaaag 1567021 aacagcgatt aaattaatcg tggagcctcg ctaaaaacaa ataaagcatt ctcaacctgt 1567081 ttgcgtaatg caaacaggtt gtttttcatt tattgtgata ttttctcccg atagtatttt 1567141 tagcacataa atgagcgaat atacaaaatc agaaatgagc taaaacgttt caaaaaaaat 1567201 ttccgcccat ttttcaagac agatactttt gtccttctgg aaaagacagt tctgtttacg 1567261 cttattccat atcatggtac aatccgaata taacaagaat ttttcaagga ggattgtaca 1567321 tgcagagtgg aaagatgaaa gctctaatga aaaaggacgg ggcgttcggt gctgtgctga 1567381 ctgaagttcc cattcctgag attgataaac atgaagtcct cataaaagtg aaagccgctt 1567441 ccatatgcgg cacggatgtc cacatttata attgggatca atgggcacgt cagagaatca 1567501 aaacacccta tgttttcggc catgagttca gcggcatcgt agagggcgtg ggagagaatg 1567561 tcagcagtgt aaaagtggga gagtatgtgt ctgcggaaac acacattgtc tgtggtgaat 1567621 gtgtcccttg cctaacagga aaatctcatg tgtgtaccaa tactgctata atcggagtgg 1567681 acacggcagg ctgttttgcg gagtatgtaa aagttccagc tgataacatt tggagaaatc 1567741 ccgctgatat ggacccgtcg attgcttcca ttcaagagcc tttaggaaat gcagttcata 1567801 ccgtactcga gagccagcct gcaggaggaa cgactgcagt cattggatgc ggaccgattg 1567861 gtcttatggc tgttgcggtt gcaaaagcag caggagcttc tcaggtgata gcgattgata 1567921 agaatgaata caggctgagg cttgcaaaac aaatgggagc gacttgtact gtttctattg 1567981 aaaaagaaga cccgctcaaa attgtaagcg ctttaacgag tggagaagga gcagatcttg 1568041 tttgtgagat gtcgggccat ccctcagcga ttgcccaagg tcttgcgatg gctgcgaatg 1568101 gcggaagatt tcatattctc agcttgccgg aacatccggt gacaattgat ttgacgaata 1568161 aagtggtatt taaagggctt accatccaag gaatcacagg aagaaaaatg ttttcaacat 1568221 ggcgccaggt gtctcagttg atcagttcaa acatgatcga tcttgcacct gttattaccc 1568281 atcagtttcc attagaggag tttgaaaaag gtttcgaact gatgagaagc gggcagtgcg 1568341 gaaaagtaat tttaattcca taaaggggga taaacatgac gaaggaattt gagtttttaa 1568401 aagcagagct taatagtatg aaagaaaacc atacatggca agacataaaa cagcttgaat 1568461 ctatgcaggg cccatctgtc acagtgaatc accaaaaagt cattcagcta tcttctaata 1568521 attacctcgg attcacttca catcctagac tcatcaacgc cgcacaggag gccgttcagc 1568581 agtatggagc cggcaccgga tcagtgagaa cgattgcggg tacatttaca atgcatcaag 1568641 agcttgagaa aaagctggca gcctttaaaa aaacggaggc ggcacttgta ttccaatcag 1568701 gcttcacaac aaaccaaggc gtactttcaa gtattctatc aaaagaggac attgtcatct 1568761 cagatgaatt gaaccatgcc tctattattg acggaattcg actgacaaag gcggataaaa 1568821 aggtgtatca gcacgtcaat atgagtgatt tagagcgggt gctgagaaag tcaatgaatt 1568881 atcggatgcg tctgattgtg acagacggcg tattttccat ggatggcaac atagctcctc 1568941 tgcctgatat tgtagagctc gctgagaaat atgacgcatt tgtgatggtg gatgacgccc 1569001 atgcatccgg agtacttggc gaaaacggca ggggaacggt gaatcacttc ggtcttgacg 1569061 gcagagtgca tattcaggtc ggaacattaa gcaaggcaat cggagtgctc ggcggctacg 1569121 ctgcaggttc aaaggtgctg atcgattatt tgcgccataa aggccgtcca tttttattca 1569181 gcacatctca tccgccggca gtcactgcag cttgtatgga agcgattgat gtcttgcttg 1569241 aagagccgga gcatatggag cgcttgtggg agaatactgc ctattttaaa gcaatgcttg 1569301 tgaaaatggg tctgactctc acgaagagtg aaacgccgat tcttcctatt ttaataggtg 1569361 atgaaggtgt ggcaaagcaa ttttcagatc agctcctttc tcgcggtgtt tttgcccaaa 1569421 gtatcgtttt cccgactgta gcaaagggaa aagccagaat tcgcacgatt ataacagcag 1569481 agcacaccaa agatgaactg gatcaggcgc ttgatgtcat cgaaaagacg gcaaaggagc 1569541 tccagctatt gtaacaagag gaagagttta ctcttcctct tttgattcct tattgattat 1569601 tattctcaat gagtgtacaa tgataggttg ccagttgtgc agagcttcaa taacctttat 1569661 actgaagggt ggaagtttgg tttgaaagga gaaaatatga catgaatgaa aaacaaaaat 1569721 tagagagcgg acaagttcat ccatcggaca aaaaatccga gaaggattac agcaagtact 1569781 ttgaagctgt ttacattccg ccttctttaa aagacgcgaa aaaacgaggc aaggaagccg 1569841 ttacttatca taatgacttt aaaatttctg aacaatttaa aggattggga gacggaagaa 1569901 agttctatat ccgtacgtac ggctgccaaa tgaatgaaca cgatacagag gttatggcag 1569961 ggatctttat ggcgctcggt tacgaagcga caaactctgt tgacgatgcc aatgtcattt 1570021 tgttaaatac atgtgcaatc cgtgaaaatg ctgaaaacaa ggtgtttggt gagctcgggc 1570081 acttaaaagc actgaaaaaa aacaatcccg atctgatttt aggcgtgtgc ggctgtatgt 1570141 cccaagagga atcagtcgtg aaccgtattt tgaaaaaaca tccgtttgtc gatatgattt 1570201 tcggaacgca taacattcat cgcctgccgg agcttttgtc agaagcatac ctttcaaaag 1570261 aaatggttgt agaagtttgg tctaaggaag gggacgttat tgaaaacctt ccaaaagtcc 1570321 gaaatggaaa aattaagggc tgggtcaata tcatgtacgg ctgtgacaaa ttctgtacgt 1570381 attgcattgt gccttacaca cgcggaaaag aaagaagccg ccgccctgag gatatcattc 1570441 aggaagtgag aaggctcgca agtgaaggct ataaggaaat tactctgtta ggccaaaacg 1570501 taaacgcgta tggaaaagac tttgaagata tgacgtacgg acttggtgat ttgatggatg 1570561 aactgagaaa aatcgatatc ccgagaatcc gttttacaac gagtcatccg cgcgactttg 1570621 acgaccgcct cattgaagtg ctggcaaaag gcggaaatct gcttgatcac attcatcttc 1570681 cggttcaatc aggaagctca gaagttctca agctgatggc ccgcaaatat gacagagagc 1570741 gttacatgga gctggtgcga aaaattaaag aagcaatgcc aaacgcttct ttgacaacgg 1570801 acattatcgt cggatttcca aatgaaacgg acgaacagtt tgaagaaacg ctttctctat 1570861 accgtgaagt ggagtttgac agcgcctata cgttcattta ctctccgcgt gaaggcactc 1570921 cggctgctaa gatgaaagat aatgtaccga tgcgtgtgaa aaaagaacgc ctgcagcgtc 1570981 taaacgcact ggtgaatgaa atttctgcta aaaaaatgaa ggaatacgaa ggcaaggttg 1571041 tcgaagtatt agttgagggt gaaagcaaaa ataaccctga tattcttgct ggctatactg 1571101 aaaaaagcaa gcttgtcaat ttcaaagggc cgaaggaagc catcggcaaa atcgtccgcg 1571161 tgaaaatcca gcaagcgaaa acatggtcgc ttgacggaga aatggtagga gaagcaatcg 1571221 aggtgaaatg agatgacgct ctactcaaaa aaagacattg tgcagcaggc tcgaaacctt 1571281 gcaaaaatga tttctgaaac agaagaggtt gattttttca aacgggctga agcgcaaatc 1571341 aatgagaatg acaaagtgtc cacaatcgtt aatcagatta aagccctgca aaagcaggct 1571401 gtcaatctga agcattatga aaagcatgaa gcgctcaaac aagtagaagc aaaaattgac 1571461 gcgctgcaag aagagcttga agagattcct gttatccagg aattcagaga ctcgcaaatg 1571521 gaagtaaatg acctactgca gctcgttgca cacaccattt ccaaccaagt cacaaatgaa 1571581 atcatcacat caaccggagg cgacctgctg aaaggggaaa ccggttcaaa ggtgaagcat 1571641 tcaaataaca gctgttctct ctaaacacgg tgcctttaca ggcccgtgtt tttttatcat 1571701 ttgtgcggtt aaaaatgaac taaataatct atgtaccaaa tgttcaattg gtttttctgt 1571761 gctcagccgc gtataaactt tatcgcactt ataagtaaag tttctaggca cccctgcata 1571821 caatggaaca gaaactttgt atttttatat tttatttata aaaatgcaca ctagacaaat 1571881 gcccagcata agataacacg aagaagaaca aggaggcatg ccggaatgtc tgaatacagg 1571941 gaaattatta cgaaggcagt agtagcgaaa ggccgaaaat tcacccaatg caccaacacc 1572001 atctcgcctg agaaaaaacc gagcagcatt ttgggtggtt ggattattaa ccacaagtat 1572061 gacgctgaaa aaattggaaa aacggtagaa attgaagggt attatgatat aaacgtatgg 1572121 tactcttacg cggacaacac aaagacagag gttgtcacag aacgggtaaa atatgtagat 1572181 gtcattaaac tcagatacag agacaataat tacttagatg atgagcatga agtgattgcc 1572241 aaagtgcttc agcagccaaa ctgccttgaa gtgaccattt cgccgaatgg aaataaaatc 1572301 gttgtgcagg cagaaagaga atttttggcg gaagtggtag gggaaacaaa ggtagttgtt 1572361 gaggtcaatc ctgactggga agaggatgac gaggaagatt gggaagatga gcttgatgaa 1572421 gagcttgaag acatcaaccc ggagttttta gtgggagatc ctgaagaata aaaaagggac 1572481 taggggagac agtaccccca agtctctttt ttatattgat atatcattct tttatcactt 1572541 tttgtttatg ttataatgaa ggttggaaaa tagaaacgtt gatacatagt gagggattaa 1572601 acaatggccg gttatacgcc tatgatacag caatatttaa aaataaaggc agagcaccag 1572661 gatgcctttt tattttttcg cctgggtgat ttttatgaaa tgttttttga ggacgccaaa 1572721 aaagcgtcac aagagctgga aattacgtta acgagcagag acggcggtgc ggctgaaaaa 1572781 ataccgatgt gcggtgtgcc gtatcattct gcttccgcgt atatcgaaca gcttattaaa 1572841 aaaggataca aagtggcgat ctgtgaacag acggaagatc cgaaagccgc aaagggcgtt 1572901 gtgaaaagag aagtagttca gctgattacg cccggaactg taatggacgg caaaggcatc 1572961 catgagtcgg aaaataattt tatcgcatct gtttcagcct gctcgaacgg atacggactt 1573021 gctctgtctg atttaacaac gggagaaaat ttggctgttt tgattgaacg gcttgaagac 1573081 gtcatatcag aaatttattc agtcggcgca cgggaaatcg tggtttcagg aagcttggat 1573141 gccgatacag tggcacagct gagagagcgg tgcggtgcaa cgatttcaat tgaagacgga 1573201 gaaacagacg aacacgtaac gatcattgag cacttaaata atgaagatat aacaaaaaca 1573261 tttctgcgct tatatacgta tttgaaaaga acccaaaagc gcagccttga tcatcttcag 1573321 cccgtgcagg tgtatgagct tgaggaagcg atgaaaattg acttgtactc aaagcgtaat 1573381 ctggagctga ccgaaacgat tcgttcgaaa aataaaaaag gctccctttt gtggctgctg 1573441 gatgaaacaa aaacggcaat gggaggccgg ctacttaaac agtggattga ccggccgctt 1573501 atcagagtca atcaaatcga agagcgccaa gaaatggtgg aaacattaat gtcccatttc 1573561 tttgaacggg aagatctgcg tgaacgttta aaagaagtat atgacttaga acgccttgcc 1573621 ggccgcgttg cattcggaaa tgtcaatgcc cgggatttga ttcagctgaa ggaatcgtta 1573681 aagcaagtgc ctggcatcaa acagctggtt gcttcactgg ctcatgacaa ggccaaggaa 1573741 cgtgcaaagc gcattgaccc ttgcggggat gtacttgaac tgctggaaga agcgctgtac 1573801 gaaaaccctc ctttatcggt aaaagaaggg aacctgatta aagatggtta taatcaaaag 1573861 cttgatgaat atcgtgatgc aagcagaaac ggaaaagact ggattgcccg cctggaacag 1573921 caggagcggg aatacacagg cattcgctct ttaaaggtcg gctttaataa agttttcggt 1573981 tattacattg aagtgacaaa agcaaacttg catttgcttg aggaagggcg ttatgagcgg 1574041 aagcagacgt taaccaatgc agagcgctac attacacctg aattaaaaga aaaagaagcg 1574101 ctcattttag aggcggaaaa taacatctgt gagctggagt acgagctgtt taccgagctg 1574161 cgcgagaaag tgaagcagta tattccgcgg ctgcagcagc ttgcaaaaca gatgagcgag 1574221 ctggacgcac tgcaatgctt tgcgacaatc agtgaaaatc gccactacac gaaaccagag 1574281 ttctctaaag atgaagtcga agtgattgaa ggcagacacc cggttgttga aaaagtcatg 1574341 gacagccagg aatatgtccc gaacaactgt atgatgggcg ataacagaca aatgcttctc 1574401 attacaggtc caaacatgtc agggaaaagc acgtatatga gacaaatcgc gctcatttcc 1574461 attatggcgc aaatcggctg ctttgtaccc gcgaaaaaag cggtgctccc gattttcgat 1574521 caaattttta cgcgaatcgg cgctgcagat gatttgattt ccggacaaag tacatttatg 1574581 gtagaaatgc ttgaagcgaa aaatgcgatt gtcaatgcga cgaaaaacag cctcattctg 1574641 tttgatgaaa tcgggcgggg aacgtccact tatgacggca tggcgctggc acaggcgatt 1574701 attgaatatg ttcacgatca tatcggcgcc aagacgctgt tcagcacaca ctatcacgag 1574761 ctgaccgttc ttgaggacaa gctgccccag ctgaaaaacg ttcatgttcg cgctgaagaa 1574821 tataacggaa cggttgtctt tcttcatcaa attaaagaag gtgcggctga taaaagctat 1574881 ggtatccatg tagctcagct tgccgaactg ccgggagatc tgattgcgcg cgctcaagat 1574941 attttaaaag agcttgagca ttcaggaaac aaaccggaag tgccggtgca gaaacctcag 1575001 gtgaaagaag agccggcaca gctgtccttt tttgacgaag cggaaaagcc ggctgaaaca 1575061 ccaaagcttt caaaaaaaga aaagcaagtg atcgatgctt tcaaatcact taatatactg 1575121 gatatgacac cgcttgaagc gatgaatgaa atgtacaagc tgcaaaagaa attacattaa 1575181 aacggggtga tgaatgtggc aaaagtcatc caactgtcag atgagctttc aaataaaata 1575241 gcggcgggcg aggttgtgga acggcccgcc tcagtcgtca aagaattggt ggaaaatgcg 1575301 atcgacgctg acagcacagt cattgaaatc gatattgagg aagcaggcct tgcatccatt 1575361 cgggtcttgg ataacggcga aggaatggag aatgaagatt gcaagcgagc tttccggcgc 1575421 cacgcaacga gtaaaataaa agatgaaaat gatttattca gggtgagaac gctcggtttc 1575481 aggggagaag ccctgccgag tatcgcgtca gtctctcatc tggagattac aacaagcact 1575541 ggtgaaggag ctgggacgaa gctcgtcctc caaggaggaa acatcatttc cgaatcgcgt 1575601 tcctcaagca ggaagggaac tgaaattgtc gtttccaacc tgttttttaa cacaccggcc 1575661 cgtttgaaat atatgaaaac cgttcataca gagcttggaa acattacaga tgtggttaac 1575721 cgtattgctc tggcgcatcc agaggtatcg atccgcctgc gccatcatgg gaaaaacctg 1575781 cttcaaacga acggaaacgg agatgtgcgc catgtactgg cagcgattta cggcacggct 1575841 gtcgccaaaa aaatgcttcc gctgcatgtg agctccttgg attttgaagt aaagggatat 1575901 atcgccctcc cagagattac acgggcgtcg agaaactata tgtcgtctgt ggtcaatggc 1575961 cgttacatta aaaatttccc gctcgtcaaa gcggttcatg aaggctatca tacgcttctg 1576021 ccgatcggac gccatccgat tacttttata gaaattacga tggacccgat tttagtcgat 1576081 gtcaacgtgc atccatcgaa gcttgaggtc cggctcagca aggaaacaga gcttcatgac 1576141 ttaatacgtg acggaattaa agatgtgttt aaacagcagc agctgattcc tagtgcccag 1576201 gtcccgaaaa aatcagcacc tgccatcaaa aatgagcagc agtttataac ctttgatgaa 1576261 aagcctccgg aaaaaaaagt tccggaaaaa tcgactgcgc catcttattc accgatgaag 1576321 ctcagctcag tcgtaaaaga gccggttgat gcggaggaaa aattgccccc tctccaattt 1576381 gatgctcctc ctatcgttga tcaggaacaa acccttgagg tgtccgatgt ttcagcagaa 1576441 cagcctgaaa catttgagca ggaatgccat gaggaacagc cgcagccagc gtctgatcgg 1576501 gttccaatta tgtacccgat tggccagatg cacgggactt atatattggc acaaaacgaa 1576561 aacggcctat atattatcga ccagcacgcc gcccaagaac gtattaaata tgagtacttc 1576621 cgtgaaaagg tgggggaggt tgagcctgag gtgcaggaga tgattgtacc gctgacgttc 1576681 cactactcca caaatgaggc tttgattatt gaacagcaca aacaagagct cgaaagcgtc 1576741 ggtgtctttt tagagtcatt cggctctaac agttacatcg tccgctgcca cccagcctgg 1576801 tttccaaagg gagaagaagc agagcttata gaagaaatca ttcagcaggt gctcgactcc 1576861 aaaaatatag atattaaaaa acttcgcgag gaagcggcga ttatgatgag ctgcaaaggc 1576921 tccatcaaag caaatcgcca cctcagaaac gacgaaatca aagcgcttct ggacgacctc 1576981 cgaagcacat cagacccatt tacatgcccg cacggccgcc cgatcatcat tcaccactcg 1577041 acatatgaga tggaaaagat gttcaaacgc gtgatgtagc gggggtggta ggcattgatc 1577101 cattctctga atggatcaat gctttttttg tactccttcg agtgtcagat tataagaaac 1577161 ggttgtaaac gtgtgagcag tgttaacgca ttatacttca tggttcctcc gtataacaaa 1577221 atttccattt acaggcaatt gggattaatg tatattttgg gtgagggggt ggaaacatat 1577281 ggcatgtggt ccgaagatca ttatcttttt ggatgaactt gatgatccaa atgtgagaat 1577341 cattttagaa tgcagaattt aaattacaac attgtgtttt gctccctgtt cgtgtgaaca 1577401 gggagatttt ttcgtttata taactggtga tgtccaaata tagggtgtta tgaattttcc 1577461 atatctgcca tcggctttaa gctgcttctc tattaggctg gttatcaaaa gcaagttcaa 1577521 tgatagccat gaaagctgat atcacaacaa gcaagacatc tggaatataa atagactgca 1577581 taaagtaatc tgcaaaacag atcgttataa gattgctgat aaaatacagt ataaaagcaa 1577641 aaagtgcagt ctttttcaat gaaagtgatt ttgccaaaat gatagagata atctttgtga 1577701 gtgggtctat gattaaacct acagcaaagc aggctaaaat aaataaagct aatgtttgat 1577761 tggaagcgta tgtgatgcca agtatggaga ataagccttt catcccgaag aaaaagccgc 1577821 cgaagatgac tgcaagcgcg atggccgcga taaaagtaat agatacaatt ccgattaatt 1577881 ttgatctcag gttaaaatct ttagagtgct cgttctgttc tttttggttc atgtatgaca 1577941 ctcccttcac ctgcttactc atacaaacag cacccttgaa tcagcccaaa atatctataa 1578001 gtctgttttc tgacgaaaat agtatagcat attttaacaa aaccaaaaaa ggccctttcc 1578061 actggggaag ggcctttttc atcatgttaa ctcctgagat tcgccgaagc tttctctttt 1578121 tttggccaaa taaaatagct ggctgtaatg agaaagtcaa tgcctataat gacagtccac 1578181 agtttaagaa tgccgctcaa cgcctcggtt cgggaagagt cattgataaa atagatcatc 1578241 cctgccaata gtcccgcacc aattaagtag gccagcacat gtcttagcca gcctttcgca 1578301 ccgtgcttgg catggtccat tccaaaacgt ttcagcggtt ttgttccttt ttttgtcaca 1578361 taatattgaa acttttcatc tgcccattga atcatttgtt tcccataagc gatcgatata 1578421 ccgatgtaaa cagctgcaat cccatgggct gcggtcgctg aggctccgcg gtaaaggtcc 1578481 acaccagttg ccgctaacaa gatcaaatcg ataactggag ttaaggcaag gaatagcagt 1578541 cctaatgtat gtcgtttgaa tacgtagcgt acagcaagcc ccaaaacaat gacaacccaa 1578601 aacgcaattt cacagaaaac aatcatccat gcgataccgt tcaatccatt cccctctttt 1578661 caatacagtt gtattattta aataatatgt taccatcttt gtttttgtaa cacaactgta 1578721 ttataaaaat tgccccgcct ttgaacgaaa gctcaaaggc gctacgctgt attattttga 1578781 tgaaagtggc tgtcagctgt gctggatatc aattgtatat actgcacgat ctgttacgac 1578841 cttcaatcct tcgttttctt ggtgaatatg aagctcacct aataaaggaa tctcataggc 1578901 attttgcgga agcggtacgt ttccgtcctc agtgaatgtt gttccttcgc cttctaaaac 1578961 aagctcttct ttcgcaacat aatcatcagg atgattcgta ctgcgtatag ccactttttg 1579021 aaggtggaga acaatctgat ccaagtctga tatctcttca tcatgggtca attcaccttt 1579081 tctaatatca agcgtctggc cgacttttga ttccagccat tgagaaagct gtgtattcgt 1579141 gtgtgccatc aatattcctc cttttgatct acacgatact attcccaatt gctgcatctt 1579201 ttacacggga aagagccgcc ccactcttta tgtatgaaac agttcgctgt tgagtgcctt 1579261 gatatagcgt acggcagaac gctggaccga ttcgtcggca ttttctttga caactttaga 1579321 gaaagcattg taaagccggt tgaattgaag cggttttact ttggctgcta tttcttcaac 1579381 tttggaggcg ggaaggggaa tgagatttgg gtagctgtac ataaagctga cccagtttcg 1579441 atccgccgca accgtaatga tatctccggt caatagacag cctttccctt cattgccctt 1579501 gctccaatgc aaaacagcac cgcctttaaa atgtccgccc agtcggtaaa ggtccagtcc 1579561 cggcttcata ttgagcgttt cccctgacca gaagtgaatg tgattgcttg gccttgtcac 1579621 ccattcttta tcatcctcat ggatatagat cggcgcctga aacgcttcag cccactcaac 1579681 ctgagtagag taataatgtg gatgagacaa ggcgatggct tgaataccgc ctaattcgtt 1579741 gatttggtca attgtctttt ggtcaagata tgtcatgcaa tcccacagca cattgaagcc 1579801 cttatgctga ataagatggg ctgtttgtcc aatcgcaaac tctggttcag ttttgatgct 1579861 gtaaagatgc tcttcttcct ttttaaggat gttttgaagg tttcctttct cacgcatgtc 1579921 ttcaagggtt gtccaagttt gtccatcggg atgaatatac tgtctttcat cctcgcaaat 1579981 cagacacgag ttgggcggat ctacagtctg tgcatgttgc acaccgcatg tattgcagat 1580041 ataatatggc actttcttca cttccttcat ctattttcca ttattttacc ttatgattat 1580101 gaatattcaa acgaaaaaac cggcagttct gctgagagag aattgccggc ttttgatgat 1580161 gtttattggc cgggaacgga attttctgcg ttgacagcgc ccgctccgta gatattcgga 1580221 tcttcatctt tccatttgtc cgtgccgttt ttcaaaagct cttttacttc atcaggggta 1580281 agatccgggt tttgctgaag aattaaagct gcgattcctg cgcaaatcgg tgttgccatc 1580341 gaggttcctg acattgtaaa gtactgagac cctacacggc ttgacttttg gagcttatca 1580401 atataagaat tcggagagcg aagggaaata atattaacac ccggcgctaa aatatcgggc 1580461 ttttctttcc cgtatactgt cgggccgcgg cttgagaagg aagcgacagt atcatcatcg 1580521 ctgcttgcag tattgttatc gtcaagcgca cctactgtaa tcaccttttc gctcacgccc 1580581 gggcttgcaa tggtctgcga atcagggcct gagtttccgg cagcgacaca gacgacaatc 1580641 cctgcgctcc acgcttcctc aaccgctctg actaacggat cttcctgttc atgatcatat 1580701 ctaagggcat cgcccccgag cgacatgctc ataatatcaa tcggttcatc ggggttgtcc 1580761 tcattgtatt gaatacacca ctcaacaccc tctataatat ctgctaacgt tcctgaaccc 1580821 tgcttgttta atacctttac gccgatgaga ttggcttccg gtgcaggtcc gcggtattga 1580881 ccggaagagg atgcaccgct gcttgcgaca tcacctgcac agtgtgtgcc atgaccatta 1580941 tcatcgtacg gctctgtttt ttgattgacc atgtccgcga atccgataat tcttccttct 1581001 agatcaggat gcgggtagat tcctgtatcg acaacagcga cagtaacacc ttttcctgtc 1581061 agggtttgcc cgtttctgac gacttccttc gcatggcttg cttcggttgc cgtgtctaaa 1581121 agcgctttga cttcgcggtt taaatacact ttacggatat tgctgcattc agagagaagg 1581181 gaatgtaatg ctgaaggagt aacctcggcg ctgcagcagt tgattttgtt gaagcggctt 1581241 tttagcttgc tgcgtttttc tttttgcagc acctctccag ccatttgaaa gccggtctcg 1581301 tgacagcctt cctcaaattc gataatgact gacatttttt ttctgttttg caatttggtt 1581361 tcgaaaaatt tatgcaagaa gcaaggagtc catttgaagg gcttgtaaag ttgcaatacg 1581421 gtttcccgta acggccaatc tagcttgtga gcatttgctc tcaccatttg taccatagag 1581481 tacccaaaca tgtattttcc tcctattata aggttctctg tatactctat gaacagatga 1581541 taggtttggt aagtttgttt gtcctctgta agagacagac aagagtttgt ttttctgaat 1581601 ctttcgcatt agatacgata gattcagaag ctgaggaaat cattggggat tgaaaaagaa 1581661 cgtttgttcg tattataatg tgatcatatc aaactgggaa ggggagagca accgtatgaa 1581721 tttctacttg caccgatctt tggaaagcca aatgccaatc agcattatat atgaagaaag 1581781 acggaacgat tagtaaaaga acgattattg tgagacagaa aagcaaaacg aaaatcaaag 1581841 cattttgttt ttcgaaacaa cagatcagaa catttttatt ggactctatc ctctcctgtg 1581901 attttgtgag aacaaataag caaaatctct attctgcagg ccggtaacag ctgtccgtct 1581961 cagcaaccgg gcagcctgtt actaaaaccc tccttaaacc tatatacatt tatttgccaa 1582021 gtgaggttgt tcctaccttt tttgtctttc ctctcaacct tttttcactc ttatttgaaa 1582081 tgaaccgcta ataaccgtga caatcaattg attttttgaa accgggaact ttttcactga 1582141 tgatattgtg tatacaatgg taagataaaa cctattggct aaacctcata taatgaaccg 1582201 cgccattctt atgaaaggag ttaaacatga gaagattttt actaaatgtc atattagtct 1582261 tagccattgt cttgttcttg agatatgttc attactcatt ggaaccagaa ccatcaaatc 1582321 agccagatac atattcaaat ttcagcagct tggcagagaa tgagagccca gccgattacg 1582381 atatttcata taatgagaaa aaaggaagca aagtcttaat tatgtctccg catggcggaa 1582441 gaattgaagg cggagtaagt gagcttgtgc gttatttcaa taatgaatac tctacatacc 1582501 tatttgaagg gttgaagtcc catgataacc aaacactgca cattacaagc accaactttg 1582561 atgagccatt ggcaaaaaag aaaatcaagg agcatcaata tgtggtggct tttcacggat 1582621 ataaaggaga gaacaagaat acccttgtag ggggaacaga ccgaaagcgg gcgaaaatga 1582681 ttgtgagagc ccttgagcgg agagggtttt ccgctgagtt agcgtcgtct aaaagcggtc 1582741 ttgctggatt gaatgccgaa aacattaata accaagggga aacggggcta agtatccagc 1582801 tggaaatcag ccgtgagcag agagaagcat tttttgatga tttttattat aaaaatagaa 1582861 aatacacaaa gaacagtgaa ttttatgctt atgtcagtgc gatcaaaggt gtcctggaaa 1582921 aagagtattc gtaacaagca gatcagaaga caaaataaga gaagatcagt agactgaaat 1582981 aggataaaaa aggaggcaaa acaatggcag atcatcattt ttatttaaaa gcgaactggc 1583041 cgggtaaccg taatgatgtc ggtacgatcg aaagcggaaa cctgatcaca tcgatttcca 1583101 ttcctaaaga aatggatggc ccgggagaag ggaccaaccc agatgaaatg cttctcgggg 1583161 cggcagcgac ctgttacatt attacacttg cagcgatgat ggagagaagc gggctggaaa 1583221 aagaagactt acagatggag tcagaaggca ttgtcaacgt tacaaaagga gtctttacat 1583281 acaaaaagat cattcaccgt ccctctgtcg tgcttaaaca tgatgcttca caagacgacg 1583341 tcgcattggc gcacaaactt tgtaaaaaag cggagtcgtc atgcatgatt tcgcgtgcaa 1583401 ttcaaggaaa tgtcgagctg cagcttgaag cctctgtgaa actgggtgga gaataaagaa 1583461 aacagacggt cactcacagg ccgtctgttt tttatcttca gcgtgggctt tcgattgatt 1583521 tagcacgacc acgcctgcaa tgacaagcgt gagaccgaat acacctttta aactgatggt 1583581 ttcgccaaaa agcaaaaacc cgacaattgc tgtaagcgcg gtaccaacgc ccgaccatgt 1583641 tgcatacgcg cttgataagt caattgtttt taaagaaaag cttagaaacg taaaagcaga 1583701 aagaaatccg actatgactc cggcaatggg ccaggcttgt gtaaatcctt ctgaaagctt 1583761 caacatcgtg ctcccaaaca cttcagatac aatggcgaga gccaaataaa gcaatcctct 1583821 catcttcatc actcctttac ggccaattaa gtaacacgac ccctgatagt aataaaagaa 1583881 tcccgataag ccctttggca ttcagatctt ccttgaacca ttttactccg atcactgtcg 1583941 tcagcaccgt gcctgccccg ctccaagtcg cataggagag gctcagggga atatggttta 1584001 aagtcaggga cagcatataa aaggcgaggg aatagccaat aacgaccaaa gcacttggct 1584061 tccacttttt gaagccatca gatactttca gcatggctgc tcctatcgat tccgaacata 1584121 tggcaatcgt gaggaatata tatcctatca acatcatgaa ttctcctcac tatattttta 1584181 gattagaaaa aaaacttcag ctagaaaaat attagtgtat gcctatgtat gagtcaagag 1584241 attcattttc acacacttaa aaagacccct ttttaagggg tcttttgcgt ttaataataa 1584301 aaagggaacg gggcatacgg ataatagggg tatccgccat acaaataagg attaaataaa 1584361 gcgcttccta taagcccgcc tgcaaggccg ccgataaacg gtcctccaaa aaatccgaat 1584421 ggccggccaa acccataacc aaatccgggt cttccaaacc cgtaaccgaa cccgaacggt 1584481 cttccaaacc caaatggtct cccgaatccg aacggccttc caaatattct tgtatcttca 1584541 gggctgaaat gctctaactc gttcatgttt tctttcctcc tgtaataaag tgtagatgat 1584601 gcagtgtatt caccctgccc ggatttgatt gggcgaatcg aggaaaagga ggatgtgaac 1584661 acattgggcc tgtatcagtc tgactggtca aaagcaccgc cccacgcaca tgcttatcat 1584721 gtcaaaacaa cgagagaaca gggccattat catctcatcg aagggtttac tcagccggca 1584781 aacggatcaa ataccgatca gcatacacat tactatacag ggatcacttc atttgaaaac 1584841 ggccattttc atcggtatta cggaatctca ggaccggcga ttcccttagc agatggcaca 1584901 cattatcatg aaatcgaaga aacgacgtat ctggcctata acgagccgat tgagatccag 1584961 tacggagggg ttgtgtacga tcccggagat gacagaagaa aaacgcatcg tcataccctg 1585021 aaaggaaaga caagggaaat tgtcggcaat gagccgctcg gctggtagaa ggatgtttac 1585081 cgatgcaaaa aaagggcaaa atggataggt ggttgtccat gttgaatgct ataatggggg 1585141 gagatttata aaagagagtg atacatattg aataatacga agcagcccgt tgtcatttta 1585201 gtcggaccga cggcagtggg gaaaaccaat ttaagtattc agctagccaa atccttaaac 1585261 gcggaaatta tcagcggaga ttcgatgcag atttataaag ggatggatat tggaacagct 1585321 aaaattaccg aacaggagat ggagggagtg ccccatcatc tgattgacat tttagatccc 1585381 caagactctt tctctactgc cgattatcaa agcttagtaa gaaataaaat cagcgagatt 1585441 gcaaatagag gaaagcttcc gatgattgtc ggcggtacag ggctttatat acaatctgtg 1585501 ctttacgatt atacatttac ggaagaggca aatgatcccg tgtttcgaga gagcatgcaa 1585561 atggctgctg agcgggaagg cgctgacttt cttcatgcca aacttgctgc agcagatccc 1585621 gaggcagcag ctgcgattca tccgaataat acaagaagag tcattcgcgc actggaaatt 1585681 ttacatacgt ccggaaaaac gatgtcccag catttgaagg aacaaaaacg agaacttctg 1585741 tacaatgcag tgttaattgg cctgacaatg gatagagaca cgctttacga aagaattaat 1585801 cagcgggtcg atttgatgat gcagtcaggc cttcttccgg aagtgaaacg cttatacgac 1585861 aagaacgtga gagactgtca atcaatacag gcgataggct ataaagagct gtatgcatat 1585921 tttgacggtt ttgtgacact ttccgatgct gtcgaacagc taaagcagaa ctcgaggcgg 1585981 tatgcgaaac gccagctgac gtggtttcgc aacaaaatgc aggtcacatg gttcgatatg 1586041 acaccgcctg ttgatatgga gctgaaaaaa aaggaaattt tcacacatat agcaggaaaa 1586101 ctcgaacttt aatcgaaact gtatgatata gagaatcaag gaggacgaaa catgaaaccg 1586161 attaatattc aggatcagtt tttgaatcaa atccggaaag aaaatacgta tgtcactgtt 1586221 tttttgctga acggctttca gttgcggggc caggtgaaag gctttgataa ctttaccgta 1586281 ttgttggaat cggaaggtaa gcagcagctt atatataaac atgcgatctc aacgtttgcg 1586341 ccgcaaaaaa acgtccagct tgaactcgaa tagatcaaaa aatgccatgt caagacatga 1586401 ggaaaggctg tcgggggttc ccggcggcca tttttaacat gaatccactt ttgctccaag 1586461 ctttttgtgt aagctgacca tgccaaggca cggtcttttt ttatgagaac aacatacgga 1586521 agtaaaaatg gtatattatg tataaaatga atttgggagt gatcgatctt gtttgaaagt 1586581 gaagcagaac tgagacgaat caggattgca cttgtatgga tagctgtctt tttactgttc 1586641 ggggcgtgcg ggaatcaaga taccattatt gaaacagaca acggcaattc agactatgaa 1586701 acgcctcagc ccacctcgtt tccacttgaa cataaccatt ttggcgttat ggaggacggc 1586761 tatatcaaaa tttatgagta taatgagtcc cgcaatgagg taaagctgaa gaaagaatac 1586821 gcggatgatg agcttgaata aaattcacaa gcattcgaat ttacaaagcg gatgccagcc 1586881 gctaaactaa atacagacac agatcaaaca gagggtgaaa acatgaagca taaagtgatc 1586941 gtgaatcatt gggaagaaat ttgcgaagat gattcttgct atgaatacgg aacaagtatc 1587001 attgtgaacg gaaaagaatt aatcagagaa gcgtcaatta tcactgcttt gaaggcggtt 1587061 ttagaagaga tcggcgcgga tgttgaaata gaagaaacag tagagagcga aaaatgctgt 1587121 gatagcttaa gaaaaaaaaa tctagactac taagcagttt tttttcatgt tatgatatac 1587181 atcggctaaa aacgacaccc cgagtaggac gagagatgat tctcgttctg ctctcttttt 1587241 tgggccctaa tgagtctgcc cgtttgcctg atttgatcaa aatatgaatt tttcataaaa 1587301 acgaatctat atattgtgtt tttgctagag ggtagtatac tatatatagt gttagtgatg 1587361 agagattcat attttttgat aggtcgtgat aaaacgtggt acaaatcata tttgattcga 1587421 aaacagggaa tgttcagcgg tttgtgaata aaacaggctt tcagcagata cgcaaggtgg 1587481 acgaaatgga ccacgtggac actccgtttg ttttggtcac ctacacgaca aacttcggcc 1587541 aggtaccggc atcaacacaa tcatttctcg aaaaatacgc ccatctctta ttgggagtcg 1587601 ctgcgagcgg caacaaagta tggggcgata actttgcaaa aagcgccgat accatttcaa 1587661 gacaatatca ggtgccgatc ttgcacaaat ttgaactcag cggcacatct aaagacgttg 1587721 aattgtttac tcaggaggta gaaagagttg tcacaaaatc aagtgccaaa atggatccag 1587781 ttaaataacg aaatcatgat ccaaaaagat gggaaattcc agtttgataa ggataaagaa 1587841 gctgtacata gctattttgt agattatatc aatcaaaaca cagtcttctt tcacaattta 1587901 aaagagaagc tggattattt ggttgaaaac caatactacg aagaggaatt cttaagcctt 1587961 tattcttttg aagacattaa agaagtgttt aagacagctt acgctaagaa gtttcgtttt 1588021 ccttccttca tgagtgcgtt taaattctat aatgactatg ctttgaaaac gaatgacaag 1588081 aaaaaaatcc tcgagcgtta tgaggaccgg atctcaattg ttgcgctgtt cttcgctaac 1588141 ggcgacactg agaaagcaaa agaatatgta aacctgatga tcaatcaaga atatcagccg 1588201 agcacaccga catttttgaa tgccggcaga aaacgccgcg gtgaacttgt gagctgcttc 1588261 ttgctcgaag ttaatgattc tttaaatgac atttcaagag caatcgatat ctccatgcag 1588321 ctttctaagc ttggtggcgg ggtttctctt aacctgtcca agcttcgcgc gaaaggtgaa 1588381 gccattaaag atgttgagaa tgcgacaaaa ggcgttgtag gcgtcatgaa gcttcttgat 1588441 aacgcgttcc gttacgctga ccaaatggga caaagacaag gctccggcgc ggcgtattta 1588501 aacattttcc accgcgatat caatgatttt cttgatacga aaaagatttc tgcggatgaa 1588561 gatgtgcgtg tcaaaacgct ttcgatcggt gttgtcattc cggataagtt cgttgagctt 1588621 gcacgcgagg acaaagcggc ttatgtattc tacccgcaca cgatttataa agagtacggc 1588681 cagcacatgg atgagatgga catgaacgaa atgtacgaca agtttgtcga caaccctcgg 1588741 gtgaaaaagg aaaaaatcaa cccgcggaaa ctgcttgaaa aattggcgat gcttcgttct 1588801 gaatcaggct atccatacat catgttccaa gataacgtca ataaagtgca tgcgaataac 1588861 catatttcca aggtcaaatt ttctaacctt tgctctgaag tgctgcaggc atctcaagtt 1588921 tcttcataca cagactatga tgaagaagat gaaatcggtc tggatatttc ctgcaacctg 1588981 ggttcgctta acattctcaa tgtcatggag cataaatcaa tcgaaaagac agtcaagctt 1589041 gcgacagact ctttaacaca cgtgtctgaa acaacagaca tccgtaatgc gcctgctgta 1589101 agacgggcaa acaaagcgat gaaatcaatc ggcctcggtg ctatgaacct tcacggctac 1589161 cttgcgcaaa acggcattgc gtatgaaagt ccggaagcgc gtgactttgc aaacacgttc 1589221 tttatgatgg tgaatttcta ctccatccag cgttctgcgg aaatcgcaaa agagaagggc 1589281 gaaacgtttg atcaatatga aggatcaacc tatgcgacag gtgaatactt cgacaaatac 1589341 gtttcaactg atttctcacc gaaatacgaa aaaatcgcta atctgtttga aggtatgcat 1589401 atcccgacga cagaggactg gaaaaagcta aaagcatttg tcgctgaaca cggtatgtat 1589461 cacagctaca gattatgcat tgcgccgaca ggctctatct catacgttca atcaagcacg 1589521 gcgtctgtta tgccgattat ggaacggatt gaagaacgaa catacggcaa ctcaaaaacg 1589581 tactacccaa tgcctgggct tgcatctaat aactggttct tctataaaga agcctacgat 1589641 atggacatgt tcaaggttgt ggatatgatc gccactatcc agcagcacat tgatcaggga 1589701 atcagcttta cattgttctt aaaagacaca atgacgaccc gagatttaaa ccgaatcgat 1589761 ctgtatgcac atcatagagg aattaaaacc atttactatg caagaacgaa agatactggg 1589821 caagacagct gcctttcttg tgttgtttga ttaaaggaga gtttatagtg acaaaaattt 1589881 atgacgcagc aaactggtca aagcatgaag acgattttac ccaaatgttc tataaccaaa 1589941 acgtgaaaca gttctggctt ccggaagaga ttgctttaaa cggcgatctc ctcacatgga 1590001 agtacctcgg aaaaaatgag caggacactt atatgaaggt actggccgga cttacgcttc 1590061 ttgacacaga gcaggggaat acggggatgc cgatcgtggc tgaacacgta gatggccacc 1590121 agcggaaagc ggtgctgaac tttatggcga tgatggagaa cgctgtccat gcgaagtcgt 1590181 actctaatat tttcatgacc cttgcaccga ctgaaacgat caatgaagta tttgaatggg 1590241 ttaaacaaaa taaatatttg cagaaaaaag cgcaaatgat tgtcgggctt tacaaagcca 1590301 ttcaaaaaga tgatgaaatt tcactgttca aagccatggt tgcttccgtc tatctggaaa 1590361 gcttcctttt ctacagcggt ttctattatc cgttatattt ctacggacaa ggaaaactga 1590421 tgcaaagcgg tgagatcatt aacctgatcc ttcgtgacga agcgattcac ggcgtgtatg 1590481 tcggtctcct tgctcaggaa atttataata aacagacaga agagaaaaaa gcagagcttc 1590541 gtgaatttgc gatcgacctc ctgaatcagt tatatgaaaa tgagcttgag tatacagagg 1590601 acttgtacga tcaagtcggg ctctcacatg atgtaaagaa attcatccgc tataatgcga 1590661 ataaagcgct gatgaacctt ggatttgatc catacttcga agaggaagac attaatccga 1590721 tcgttttaaa cggattaaac acaaaaacaa aatcgcatga cttcttctct atgaagggga 1590781 atggctataa aaaagcgaca gttgagccgc tcaaagatga tgacttttat tttgaagatg 1590841 aaaaagagca gatataatat ctgctctttt cggcttgaag gttcaaatga ggaggacgca 1590901 gtacccatgg gaaaaatgga cgaaatgatt ttagttgccc cgcgcgatga tgtgtttaaa 1590961 aaagaaagct taaccttcca gggcgtgtac agtgaagata gcagagtagc agaaatcatg 1591021 gctcagattg aagcggccta tcgtgaaatg agaagagggg acgcagaaga agatccgcgt 1591081 ttcaagcagc cgatacctta tgtcgtcatt aagcgtgaag atgaagtttt tctttacgag 1591141 cggctggctg gcggcggtga atcacgtctg cacaacaagc tttctctcgg ttttggcggc 1591201 catatgaacg ccatcgaagg ggcagcttca tttgctgaag tcttaaagct gaacacagac 1591261 cgtgagcttg aggaagaact gcaaataaat gaagaagata aacaggcgat tgtcacactg 1591321 ggattgatca atgatgatga aaacagtgtt ggcaaagtgc atatcggtat tctttctgcg 1591381 cttcaattaa agcctggcgc acaagtggaa gtgaaggaga aagaacaaat tgcgggtaaa 1591441 tggatgaaag tttctgaatt aaaacaggat gatatctaca accgtctgga aacatggtca 1591501 cagtttgttg ttgatattct tgaataaaaa aacccggttt ctcgcgatga ggagccgggt 1591561 ttttttatga gacgctcgtc cccgtctcgg ctatgattct aggatcacaa tagcgtcaaa 1591621 gccggcattt ttcgctctgg cagcgagggt gtctgcattg tctttggatg aaaatgcgcc 1591681 aatctgcact ttgtataatc cgtcctttaa aaggacaatc gagtcaaaac ctttggcttc 1591741 ggcattactt gcgagcgagt cggcattcgc tttgacttta aatgcgccga tttgaacctt 1591801 atataaccct gagctggaag tctttttaag gttaaaggct tgctccagcc cgtttgcatg 1591861 tcctctcgct aagctttgaa taaaactgct cgttttcagc ttatttgcat cggaaacggt 1591921 atcaatgaag ccgttctcgg tcaagagggc aggcattgcc gactccctta ggacgtggaa 1591981 gttcgctgtt tttttgccgc gatcggcaaa gtcgacagct tgtatcactt cagagtgaat 1592041 tgtcgattga taagtcgtcg tcggggctcc tacatctgga taaatatagc tttcaaaacc 1592101 tgtgcctccc ccggaattaa cgtgaatgga caaaaagaaa tctgctcccc agttatttgc 1592161 ggcatttgtc cggtcgttta agctgacata ttggtcgctt gtccggctca gcagcagaga 1592221 aacgccttca tattcattag ttaatatcgt acgtaaggct aaagcgattt gcagggttaa 1592281 cgttttctcc tgaaggccat tacctgttgc gcctggatca gacccgccat ggccaggatc 1592341 aataaaaatt ttaaccattt ttcatcacct cattacagga tatgaaaaaa cacggcttct 1592401 gcttgtacga ttatcattca actgaaaaat gaggaaataa ccctttcaca tccagaaatt 1592461 atttctcggg aaagcgcaca attcaacatg aagcgacaac agatacggtc cgacatgaaa 1592521 tctgtgcata cgccatatgt ttgtatgtac tatgggttcg gttaacctgc actgattcct 1592581 gctggtttta agctttgcgt tcatattaaa tcaagcattt aaaacgtaaa ttgatgagga 1592641 aagctccttt cattaaagac accgctttat aaatcgaaaa aaagaaaaac acttcaggta 1592701 tcttagggcg ggtaatacgt ttcgtacaaa aatcagcccg ttgtatgaaa aagaaataat 1592761 gagaaagaag ctcactataa tactctgaca aaatgattaa aaacaaaatc tcatggtttg 1592821 tccaccccat gtccgtgaat acaataagaa ataaagtatt tctcgggaaa gcgcaggatt 1592881 ccttattgtt cccgaaaaaa gcaattgttt cgacacatga taggcgtttg tcacaatcgg 1592941 catccgcttg aatatcatat agagagaaca gagaggtgaa gatgttggag cgcgctgtga 1593001 cttataaaaa caacggacag atcaacatta ttctgaacgg gcaaaagcag gtgctgacga 1593061 atgctgaggc agaggcggaa tatcaggctg cattgcaaaa aaacgaagca aagcacggca 1593121 ttttgaagga aatcgaaaaa gagatgagcg cattagttgg gatggaggaa atgaaacgca 1593181 acatcaagga aatatacgcc tggatttttg tgaaccaaaa acgcgcggag caaggcttga 1593241 aggttggaaa gcaagcgctg cacatgatgt ttaaaggaaa tccgggaacg ggaaaaacga 1593301 cggttgcacg gctcatcggc aagctgttct ttgaaatgaa tgtcctgtca aaaggccact 1593361 taatagaagc ggagcgggct gacctggtcg gggagtatat cggacacacc gcccaaaaga 1593421 cgagagattt aatcaaaaag tcattaggtg gcattttgtt tatagacgaa gcctactcgc 1593481 tggcaagagg cggcgaaaag gactttggga aagaagcgat cgacacactt gtaaagcata 1593541 tggaagacaa acagcatgag tttattttga tactcgccgg atattcacgg gaaatggatc 1593601 attttctctc gttaaatccc ggactccaat caagatttcc catctccatt gattttccgg 1593661 attactctgt gacccagctc atggagattg cgaaacgaat gatcgatgaa agggaatacc 1593721 agctcagtca agaagcggaa tggaaattga aagattactt aatgacagtg aaaagcacga 1593781 caagtcccat taaattcagc aatggacgtt ttgtcagaaa tgtgatcgaa aaatcgatca 1593841 gagcacaagc catgaggctt ttaatgggag accaatactt aaaaagcgac ttgatgacca 1593901 tcaaaagcca agatctttcc attaaagaag aagcatctgg atctgcatag acctctcagt 1593961 ttttgagagg tctgtttttt gctcgtattt ccgcttttca aagcaatcga tttgtggtat 1594021 acacatgcag ggtttggtat gataatacta ctgcccaata tgcaaaagaa aggaacatcc 1594081 atttgaacga acaagaaacg attcaggaga aagccatttt agtcggatgt cagctgccgc 1594141 atatcacgga tgagcatttt gaaaattcta tggaagagct agcatctctg acgaaaacag 1594201 cagacggaaa agtactgacc agcgtcacac aaaaacggaa cagggctgac gccgctacat 1594261 atataggaaa agggaaggta gaagagctga aggcactcgt ggaagagctt gaagctgatc 1594321 tcctcatctt taatgatgaa ctgtcgccaa gtcagctgaa gtcattggca acagcaattg 1594381 aagtgaagat gattgaccgc acgcaattga tattagatat ttttgcaaag cgggcgagaa 1594441 cgagagaagg caaacttcaa attgagctgg ctcagctgca atatgcactg ccgcgtctga 1594501 cgggacaagg gatcaacctt tcccggcaag gcggaggaat tggggcaaga ggtcccgggg 1594561 aaacgaaact ggaaaccgac cgccgccata tcagaaatcg cattcatgaa atcaacacac 1594621 agctttccac tgtcattcgc catagaagcc gataccgtga aagaagaaag aaaaacggtg 1594681 tgcttcaaat tgcgcttgtc ggctatacaa acgcagggaa atcaacatgg ttcaaccgcc 1594741 tgacgagtgc tgacagctat gaagaagacc tcctgtttgc cacgctggac ccgatgacca 1594801 gaaaaatggt cctgccaagc ggctacagtg ttcttctttc agatacagta ggatttattc 1594861 aggatcttcc gacgacattg attgctgcat tccgctcaac gcttgaggaa gtaaaagaag 1594921 cggatttaat tctgcattta attgattctt caaatgagga ttatgcggga catgaaaaaa 1594981 cagtgcttcg gctgcttgag gagcttgaag cagatgatat cccgatgctg acggcttaca 1595041 ataaacgtga tcaaaaactg cctgatttta taccgaccgc cggaagggat cacattatgg 1595101 tcagtgcgaa atttgaggac gacgctgcag cctttaaaga agcgattcag cgctatttgc 1595161 gccaagaact gttaacgtct tttgaagcac atgtgccggc aagtgaaggg aagctccttt 1595221 ccagaatcaa atcggaaacg atggtagacc gcttctattt taatgaagaa aatgaacagt 1595281 atgacatatc cggctatgtc caagaagagc aaagtatcat cggtgaatta aagaagtata 1595341 tgtaggaagg aaatataaag acatgtttga cacattaaca cacggagaat tattgaagaa 1595401 aacggcaatg gaagtggaag cggacattgc cggcattcat aaacaaatag aagaaatcag 1595461 cgagcgaaat gagtggagag tgcttcaaag ctatagaaaa cacaaagtaa gcgacactca 1595521 tttcacgccg tctactggat acggctatga tgatatcgga agagacacgc ttgaaagcat 1595581 atatgcggat gtgtttggcg gagaagcggg gcttgtaagg ccgcaaatca tttcaggcac 1595641 acatgccatc tcaattgctt tgttcggtgt cctcagaccg ggggacgagc tcctttatat 1595701 cacgggcaag ccgtatgata cgctagagga aattgtgggc gtcaggggtg gagaaaacgc 1595761 tggttcgtta aaggattttc aaatcggcta taatgcggtt gatctgacga aagacggaaa 1595821 gatagactat gatgcagtcg ccgctgcgat caatccgaag acaaaagtaa tcggcattca 1595881 gcgctcaaaa ggatatgcga atcgcccttc tttcttaatt agtgaaataa aagaaatgat 1595941 ccgttttgta aaagaaatca atgaaaatct gatcgtcttt gtggacaact gttacggaga 1596001 atttgtggaa gagcttgagc cttgccatgt cggagccgac ctgatggcgg gatctctcat 1596061 taaaaatccc ggcggcggcc ttgcgaaaac aggcggctac ctcgtcggaa aagcgaaatg 1596121 gattgaagct tgctcatacc gtatgacgtc acccggcatc ggcagagaag cgggggcatc 1596181 tctttactcg ctccaagaaa tgtaccaagg cttctttttg gcgcctcacg ttgtgtctca 1596241 aagtttaaag ggagcggtgt ttacagcgag attccttgaa aaactcggct tcacttcaaa 1596301 cccgaaatgg gatgcgaaaa gaacggattt aatacaatcc gttgagtttt ctgacagaga 1596361 aaagatgatt gctttttgcc aggctattca atttgcatcg ccaatcaatg ctcatgtgac 1596421 gccttatcca gcctacatgc ctggatacga ggatgatgtc attatggcag cagggacgtt 1596481 tattcaagga gcaagcatcg aattatcagc tgatggccct atccgcccgc cgtatgtagc 1596541 gtatgttcag ggaggattaa cctattcgca tgtgaagaat gccatatgca gtgcagtgga 1596601 ttcattgatg caaaagcaat taatttaaat tttttaaaaa tttctctgga tttgatgtta 1596661 agaatcctta catcgtattg acacataata taacatcacc tataatgaaa ctaagttaag 1596721 aaaaggagga aattgagatg agtgataata ttcgccgctc aatgccttta tttccaatag 1596781 gaattgtcat gcagttaact gagttatcag caagacaaat tcgatattat gaggaaaatg 1596841 gactgatatt tccagccaga agtgaaggaa atagacgatt attttcattt catgatgtag 1596901 ataaactgtt agaaatcaag cacctgatag aacaaggtgt aaacatggca ggaattaaac 1596961 agattctggc gaaagccgaa gccgagccag aacaaaaaca aaacgagaag acgaaaaaac 1597021 caatgaaaca tgatctgtcc gatgacgaac tgagacagct cctgaaaaac gagctcatgc 1597081 aagccggccg ttttcaaaga gggaatacat tccgtcaagg cgacatgtcc cgcttctttc 1597141 attaatccgt tagcaactgt tttgctatat acatttacct tttaagagga ggaattttac 1597201 caaatggcaa agtacactag agaagatatc gaaaaattag taaaagaaga aaacgtgaag 1597261 tatatccgcc ttcaatttac tgacattctt ggaacaatca agaatgttga gattcctgta 1597321 agccagcttg gaaaagcgct tgataataaa gtcatgtttg acggttcttc tattgaggga 1597381 ttcgttcgta tcgaagagtc agacatgtac ctgtatccag atctaaatac atttgttatc 1597441 ttcccatgga cagctgaaaa aggtaaagta gcacgtttca tctgtgatat ttacaatccg 1597501 gatggcacac cttttgaagg tgacccgcga aacaacttaa aacggattct gaaagaaatg 1597561 gaagacctcg gcttcagtga ttttaacctt gggcctgagc ctgaattctt cttattcaaa 1597621 ttggacgaaa aaggcgagcc gacgcttgaa ctaaacgaca aaggcggata tttcgactta 1597681 gctccaactg atttaggaga aaactgccgc cgcgatatcg tacttgagct tgaagagatg 1597741 ggctttgaaa tcgaagcgtc tcaccacgaa gtagcacctg gtcagcacga aatcgacttt 1597801 aaatatgctg gagcagtccg ctcttgtgat gacatccaaa catttaaact agttgtcaaa 1597861 acaattgccc gtaaacacgg cctgcatgcg acatttatgc caaaaccatt gttcggtgta 1597921 aacggttcag gtatgcactg caatctatca ctcttcaaaa atggtgttaa cgcattcttt 1597981 gacgaaaacg cagatcttca gttaagtgaa acagcgaagc acttcattgc aggtatcgtg 1598041 aagcacgcaa caagctttac agcagtaaca aacccgacag taaactctta caaacgtctt 1598101 gttcctggct atgaagcacc ttgttatgta gcatggagcg cgcaaaacag aagcccgctt 1598161 atccgtatcc cggcttctcg cggcatcagc acacgtgttg aagtacgcag tgtagaccca 1598221 gctgcaaacc cataccttgc acttagcgta ttgcttgctg caggattaga cggaatcaaa 1598281 aacaaactgg aagcgccggc tccaatcgac cgcaacatct atgtgatgag caaagaagag 1598341 cgcatggaaa acggaatcgt tgaccttcca gcaacacttg cggaagcact agaagaattc 1598401 aaatcaaacg aagtcatggt caaagcgctg ggcgagcacc tattcgaaca cttcatcgaa 1598461 gcaaaagaaa tcgaatggga tatgttccgc acgcaagtac atccttggga acgcgaacag 1598521 tatatgtctc agtattaata tctcaatccc ttggcactaa aagtgtcagg ggatttttta 1598581 tgttaatagg taataaatta tggagcggca tagtgtttaa cacagccatt aatcctcaga 1598641 cagtcaaata gccatttcta ctccggttga aagcttctct atttttgctt cttatttatc 1598701 tttcctgtat tgatatatgt atgtagggtt ggacttataa cataaactat tctggccatt 1598761 ccgttctttc aattcatgac cgggcttgcc atcagcataa atctaggcta acagtctcca 1598821 tacatcctgt gatcaccttt atcaaactct taaatgcaac ttaccactaa ccaattcttt 1598881 atttcgcata gatcatcttt gtcatgtgtt tacacaagaa tctgttttgg actgagacac 1598941 tgaatataac aaaacagtca aaaatcaata tttaattcat tctgtttaaa ctttctgaaa 1599001 aagatgttga aaaagtcgaa aggattttat aatattaagt caagttagtt tgtttgatca 1599061 acaaactaat gaaatgaact ttcattatcc acaagataag atcttactaa tatggatgga 1599121 agggggataa gagggtcgat ttaatggagc taaacaatat aagaaacgaa agaatgaggc 1599181 ttttatcctt ttccaggtat ataaggtatg acgaaaaaag atgaattttt tgcttgctga 1599241 tcaccatatt tttttgcact gttttgaaag cgcttttata aaagtttact gaccgtaaat 1599301 tcgagaaatt gttataccgt ttcacactgt tccatattaa aggatcgaaa aggggagaaa 1599361 tcatgctcag tgaaaatgta aagaagatta gcatggttga aaaagttgga tatgcgtctg 1599421 gagattttgc ttgtaattta atttatgcaa cagtgtctac gtatcttttg ttcttctata 1599481 cagatgtttt tggtttatcg gcagcagcag ccggtactat gtttttagtg gttagaataa 1599541 tcgacgctct cgctgatcct tttatcggaa caatagttga cagaacgaac agcagatttg 1599601 gacgctttag accgtatctt ttattcggag cttttccatt tgtcatactg gcaatactct 1599661 gttttacaac accagacttt tcggatatgg ggaaattaat atatgcctat ataacctatg 1599721 ttggcttgtc gcttacatac acaacgataa acgttccata tggcgcgtta acttctgcaa 1599781 tgactagaaa taatcaagaa gttgttagta taacttctgt tcgcatgtta tttgcgaatc 1599841 ttgggggact tgtcgttgca ttttttgttc ccttactggc tgcttattta agcgatactt 1599901 ccggcaacga gtctcttggc tggcaactaa ccatgggtat tttgggaatg ataggcgggt 1599961 gccttttaat cttttgtttt aaaagcacaa aagagcgggt cactcttcaa aaatccgaag 1600021 agaaaattaa atttacggat atatttgagc agtttcgtgt taatcgtcca cttgttgtat 1600081 taagtatttt ctttattatt atttttggag tgaattccat cagtaattcg gttggcattt 1600141 actacgtaac gtataactta gaaagagagg atttggtgaa gtggtacggt ttgataggaa 1600201 gtttacccgc tttggtcatt ttaccgttta ttccaaggct tcatcaattt ttggggaaaa 1600261 agaaattact aaactatgca ttattactga atattatagg cctcttagct ttactgtttg 1600321 ttccgccaag taatgtttac ctcatacttg tctgtcgatt aatcgctgct gctggaagtc 1600381 tcactgccgg gggatatatg tgggcgctta ttcctgaaac aattgaatat ggagagtaca 1600441 ggactgggaa aagaatgggt gggctcattt acgctataat cggatttttc tttaagtttg 1600501 gtatggcctt aggaggagtt gttccgggtc tggttcttga taagtttgga tatgtagcaa 1600561 atcaggcaca aaccccggcg gccttaatgg ggattttaat tacaacaacc attattcccg 1600621 tgttcttgct tgttctagct ttaattgata ttaatttcta taacttagat gagaaaaaat 1600681 ataaaaacat ggttcgagaa ttagagaata gagacaaagt ttatttggat catattgatg 1600741 atttcaaggc ttaaaaaaga aaataaactg aggaggagtc ccaaatgaag attaccaatc 1600801 ccgtacttaa aggattcaat cccgatccaa gtatttgtag agcaggagag gattattata 1600861 tcgctgtatc tacatttgag tggtttccgg gagtccagat acaccactca aaagatttag 1600921 taaattggca cttagttgca catccattac agagagtttc acaattagac atgaaaggaa 1600981 acccaaattc aggtggagtt tgggcaccat gtttaagcta tagtgatggg aagttttggc 1601041 tgatctatac ggatgttaag gtagtagatg gcgcatggaa agattgtcac aattatttag 1601101 ttacttgtga aacgattaat ggtgattgga gtgagccgat taaattaaat agctcggggt 1601161 ttgatgcttc tttgttccat gatacggatg gaaaaaagta tttattaaat atgttatggg 1601221 atcaccgtat tgatcggcac tcatttggag gaattgttat acaggaatat tctgataaag 1601281 agcaaaaatt aatcggtaaa ccaaaagtta tatttgaagg aactgataga aaactgacag 1601341 aagctccgca tctttatcat atcgggaact attattattt attaactgca gaaggaggaa 1601401 cacggtacga acatgctgct acaattgctc gttctgcaaa tattgagggg ccatatgaag 1601461 ttcatcccga taatccaatt ttaacgtcat ggcatgaccc aggaaatcca ttgcaaaaat 1601521 gtggtcatgc atccattgtt caaacacata cagatgagtg gtatttagct catttaacgg 1601581 gacgtcctat tcatcctgac gatgattcaa tttttcagca gagaggatac tgtcctttgg 1601641 gcagagaaac agctattcaa aaactttact ggaaagatga atggccctat gtagtaggtg 1601701 gaaaagaagg aagcttggag gtagatgcac cttctatacc cgaaacaata tttgaagcaa 1601761 cgtacccgga agttgatgaa tttgaggatt caacattaaa tataaatttt caaactttaa 1601821 ggattccatt cacgaatgaa ttaggttcat tgactcaagc gccaaatcat ttacgattat 1601881 tcggtcatga atcattgacc tcgacattta ctcaggcatt tgtagccaga cgctggcaaa 1601941 gtctccattt tgaagccgaa actgctgttg agttttatcc ggaaaatttt caacaagccg 1602001 ctgggttggt gaattactac aatacagaga actggacggc tcttcaagtc acgcatgatg 1602061 aagaacttgg gcgcattctt gaattaacaa tatgtgacaa cttttctttt tcacagccat 1602121 taaataataa aattgttatt cctcgtgaag taaagtatgt atatttaaga gtaaatattg 1602181 aaaaggacaa atattattat ttctattctt ttaacaaaga agattggcac aaaattgaca 1602241 ttgcactgga atcgaaaaaa ttatcagatg attatatccg tgggggagga ttcttcacag 1602301 gggcctttgt agggatgcaa tgccaagata ccagtggtaa tcatattccg gccgacttta 1602361 gatattttcg ttataaagaa aaataatttg cacatgaaaa aggagatttc tattttagaa 1602421 ctcctttttc atatgagaag gtgccatgtc actattgctt cagaaatact cctagaataa 1602481 aaaaactcat ctttaaagat gagctgtcca ttccataaaa aattacattg taatcatgtc 1602541 cagaaaatga tcaatcacaa tggaggacat tcctaatgcc ggtgcattct gtcctaagga 1602601 agatggcaat aattcatagc tattgcctaa ttgggaataa acccttgatg atacttcact 1602661 tctcattgaa tttaaaacca taggatgcga ttcaattatg ctatttctta aaattacggc 1602721 ttgtgggttg aaagtattta gaatattggt aaggcctatt cctaaataga atccaaaatt 1602781 ttgtaatgca tttaaggttc cgatatcatt cagatgggcg aggtttatga tatcttgata 1602841 ggacagtttt ttctctttgg tctgaagaga ttttaataaa gccttctctg aagcatacaa 1602901 ttcccagcat cctcggtttc cgcaactgca tttaggacca ttaaagtcta ttgtcatatg 1602961 tcccatttct ccagagaagc cgcttactcc tctatataaa tgattgttga taataacacc 1603021 gatccctatt cctgtgctga tacttacgta aataatgtta tcgtgatttt ttgcagctcc 1603081 aaatactttt tctccatatg cgccagcatt tgcctcattt tcaataaaaa caggcacatt 1603141 gtacttctct tgtatcgaag attttaagtc aatatctctc cagttggagt tcggagtgaa 1603201 aacaattttt tgatctttat caatgagtcc aggcacgcaa atacctatac caataagccc 1603261 gtacggagat tggggcattt gcgtaataaa gtgatgaatc atatcaatca aaatgtcttt 1603321 cgttatttct ggagaattgg attccaaatg gcggtattga tcaagaacga ttgttccttc 1603381 aaggtctgtt aaaatgccat taatataatc cacaccaaca tctattccaa cggagtatcc 1603441 tgccttttta ttaaaaacaa gcatgacagg tcttcttccg ccacttgatt gtccttgacc 1603501 tatttcaaat accatacttt ctttcattaa cgtgtttacc tgtgatgaga cagttgattt 1603561 atttaatcca gtcatttcag ataattttgc tcttgaaata ggtgaatttt taaggatttc 1603621 ttttaataat aacttttgat ttactttttt gacaaaggtt tgatcagcga tatccacttc 1603681 atccactcca tttgtttaat ctttaaatta agtatcaaca tagtacatag cgaatcttcc 1603741 ctttattata tctaatgtgt tcataaaaaa ctaaaaaaaa tattgaaaat actgacgagg 1603801 ttatataaga tgaaaataag ttagtttgtt taaacaacaa actaataggt gatgtactta 1603861 ctatatgaaa taaaatgcat ctgtatttga atgaatttat ttttaagggg gaaatcacat 1603921 ggctcaatct cattccagtt caatcaacta ttttggaagc gcaaacaaag tggtttacga 1603981 agggaaagat tcgactaatc ctttagcatt taaatattat aatcctcaag aagtaatcgg 1604041 cggaaaaacg ctgaaagagc atttgcgatt ttctattgcc tattggcata catttactgc 1604101 tgatggtaca gacgtttttg gagcagctac gatgcaaaga ccatgggatc actataaagg 1604161 catggatcta gcgaagatga gagtagaagc agcatttgag atgtttgaaa aactagatgc 1604221 accattcttt gcttttcatg accgggatat tgcaccagaa ggcagtacgc taaaagagac 1604281 aaaccaaaat ttagatatga tcatgggcat gattaaagat tacatgagaa atagcggcgt 1604341 taagctatta tggaatacag caaacatgtt tacgaatccc cgtttcgtcc atggtgccgc 1604401 gacttcttgc aatgcagatg tgtttgcgta tgctgcagca caagtgaaaa aagggttaga 1604461 aacagcaaaa gagcttggcg ctgagaacta tgtattttgg ggcggccgtg aaggatatga 1604521 aacattgtta aataccgatt taaaatttga gcttgataat ttggctagat ttatgcatat 1604581 ggcagtggat tatgcgaagg aaatcgggta cacagggcag tttttgattg agccaaaacc 1604641 aaaagagccg accacccatc aatacgatac agatgcagca acaaccattg cctttttgaa 1604701 gcaatatggc ttagacaatc attttaaatt aaatcttgaa gccaatcatg ccacattagc 1604761 cgggcataca ttcgaacatg aattacgcat ggcaagagta catggtctgc ttggctctgt 1604821 tgacgcaaac cagggtcatc ctcttttagg ctgggacacg gatgaatttc cgacggattt 1604881 atattctacg acattagcaa tgtacgaaat cctgcaaaat ggcggccttg gaagcggcgg 1604941 attaaacttt gacgcgaagg tcagaagatc ttctttcgag cctgatgatc taatatatgc 1605001 ccatattgca gggatggatg catttgcaag aggattgaaa gttgcccaca aattaatcga 1605061 agatcgtgtg tttgaagatg tgattcaaca tcgttaccgc agctttactg aagggattgg 1605121 tcttgaaatt atagaaggaa gagctaattt ccacacactt gagcaatatg cgctaaatca 1605181 taaatcaatt aaaaacgaat ctggaagaca ggagaaatta aaagcgatat tgaaccaata 1605241 cattttagaa gtataacagg ataagctcca gatcctgcta tcaataccaa gtcactgaat 1605301 tacccgtcat gattcctttc ctattgcttg ttgttatgac gggtaacttc tataattagg 1605361 atttatttag agtgaatggt tttttaaaag ggcaaggagt gaaaaaatga agtatgtcat 1605421 tggaatagat cttggaacga gtgctgttaa aaccatttta gttaaccaaa acggcaaggt 1605481 ttgtgcagaa acgtccaaaa ggtatccgct catccaagag aaggcgggat atagtgagca 1605541 aaatcctgaa gactgggttc agcaaacaat tgaagcattg gctgaattgg tttctatatc 1605601 caatgttcaa gccaaggata ttgacgggat aagctattcg ggacaaatgc atggattagt 1605661 actgcttgac caagatcgtc aggtgttacg taatgcaatt ctttggaatg ataccagaac 1605721 aacgcctcaa tgtataagga tgaccgagaa atttggcgat catcttcttg acatcacaaa 1605781 aaaccgtgtt ttagaagggt ttacattacc taaaatgtta tgggtaaagg aacatgaacc 1605841 tgaacttttt aaaaaaactg ctgtgttttt gcttccgaaa gactacgtgc gattccgtat 1605901 gaccggtgtc attcacaccg aatactccga tgcagcagga actttacttt tacatattac 1605961 tcgcaaggag tggagcaatg atatttgcaa tcaaattggt atttctgcag atatttgtcc 1606021 tccgcttgtt gaatctcatg attgtgtagg atcgctgctt ccgcacgttg ccgcgaagac 1606081 cgggctatta gaaaaaacaa aagtgtacgc tgggggagca gataatgctt gcggcgctat 1606141 tggagcaggt atcctttctt ccggaaaaac attatgcagt attgggacgt caggggtcat 1606201 actttcctac gaagaagaaa aagaaagaga ctttaaaggg aaagtccact tttttaatca 1606261 tggaaaaaag gattcttttt atacgatggg cgtcacgctc gctgcaggat acagcttgga 1606321 ctggtttaaa agaacgtttg caccaaacga atcgtttgag caattattgc agggggtgga 1606381 agctattccg ataggagcca atggactgct atacactcct tatttggttg gtgaaagaac 1606441 gccgcatgct gattcttcta ttcggggaag cttgatcgga atggatggag cccataatag 1606501 aaagcatttt ttgagggcaa taatggaagg tatcacattc tctttacatg aatcaattga 1606561 gctattccgc gaagcgggaa aatcagttca tactgttgtt tctattggtg ggggagctaa 1606621 aaatgatacg tggctgcaaa tgcaagctga tattttcaat acgagggtaa ttaagttaga 1606681 aaatgaacaa gggccagcta tgggggctgc aatgctggct gcctttggaa gcggttggtt 1606741 tgaatcactt gaagaatgtg cagagcagtt cattcgtgag gctgctgcat tttatccaaa 1606801 ggcgcaaaat gttcaaaaat ataaaacact atttgatttg tataagaaca tttacactca 1606861 cacaaaggat ctcaatacag ctttgaagag ctttcgaaaa aactaatgat gttattgtct 1606921 ggagatcaac cgaagaacaa ttaatgatca atcatcatca aaggcctttg ataacatggc 1606981 tgccttcttt tgaaaagatg gtgagaataa ggtatcgcaa cctttaaaca gtattggagt 1607041 atccagcaga caaaacgaac gagtggaacc gtattttgtc agcgaacact tcaagaagtg 1607101 gggaagctta ggaatgccaa tgggtaagat gtatgaaacc gcgctaacga cggtagaggg 1607161 atctcttgat ttatgaagaa ataggaagga tgttaacaca caaataaccc ctcacattga 1607221 cgtgaagggg tgttttttat tgttactata cagcggaaat tttacaggct agttgcatga 1607281 ttttagcttg ttaagcagaa tggaactaga ctctccatca tctctttctc attctttgga 1607341 aactgcattc tgctaggttt gctgcttttt ttaacaaaca gtgtttttct atttcacaca 1607401 gccattaaat cctctgttcg tcacataacc gctcttactc caaattgaca gtttatctga 1607461 ttttgcttct tgctcatcta gtctgaattg gtctatgtat tttgtgttag gctcatatac 1607521 atatgctact ctggccaatc cctctttcaa taatgtctct tgaacagatt tgccgtcaac 1607581 ataaacgtat gctaacagtc ttccatactt atctctgcga tcgcctttat caaattccag 1607641 ctgtagctta ccgctgttga ccaattcttt atttcgtttc gacgcatcct caccgtatgg 1607701 ttgaacacaa gaatttggtt tcttcgtctc aggtgtatca acgagcaagt agcgaactgt 1607761 gtctttcttt ccgttgtaaa taaccttaat cgtatctcca tctattgctc tatctaatgt 1607821 aacattgacc aatttcttct gattttttga atgaggcgtg ccagcctttt gttctgtctg 1607881 attatattca ttagagtgag tatcttgaga gacttgctcc gtcccattag aatctgaatg 1607941 gtttttggct gcgtgatttg atccgcaagc tgccaaagta atacttaaaa cgattgcgat 1608001 catactgatc aaaatcttct tcatattgat tccctcttta tcattttctc ttttcgcgat 1608061 taaacatcat cattataacg atatggacat tttttgtgaa tggaaaactt caagggaact 1608121 tataacactc caaattgcca atagttaact tcacaacgag atgatcaaaa catcaccatc 1608181 acatagcgga aataaataat cctgaaaata atattgactg aaaatgcttt tagaattatg 1608241 ataatatgag aaatgacaat aatgtgacaa agacattact acaacataac aactaatagc 1608301 ttaggtttat tctattggtt aaaaatgtaa acggttacaa atccagaggc gaaaatctaa 1608361 gatagagatg actttagttt tgactcaata tccacactga aagagcttat taagtattct 1608421 taaaggcagg ggaaatggat atgaatgaac atcgaaatcg aaggttgaaa ttaataatga 1608481 tttcagcaac ttttggaggg cttctctttg gatatgacac cggagttata aatggagctt 1608541 taccttttat ggcaaggcca gatcagcttg atttaacacc tgttacagaa gggcttgtta 1608601 cgagtattct tttattaggt gccgcgtttg gagcgttgtt atgcggaaga ttggctgatc 1608661 gatatggccg ccgtaaaatg atccttaatc tttccttttt atttttcctg gcatcactgg 1608721 gaacagcgtt agcacctaat gttttcatca tggcggtctt tcgtttttta ctggggctgg 1608781 ctgttggagg agcctcggcg atggtgccgg cctttttagc agaaatggca ccgcatgaaa 1608841 agagagggcg tatggtaacc caaaatgaac taatgattgt tggcgggcaa tttttagcat 1608901 atgtttttaa tgcgatcctc ggtgtaacaa tggcaaatac gggacatgtt tggagataca 1608961 tgctagtcat ttgtgctgta ccggctatca tgttatttgc cagtatgctt aaggtaccag 1609021 aaagcccccg atggctaatc tccaaaggca aaaacagtga ggcgctgcga gttcttaaac 1609081 aaattcgaga agataaacgt gcagaagctg aatgtagaga aattcaagaa gcggtagaaa 1609141 aagatacagc actagaaaag gcatcactca aggacttttc tacaccatgg ctgcgccgtc 1609201 ttttatggat tggaatcggt gttgccatcg tgaatcaaat tacaggtgtg aactcgatta 1609261 tgtattatgg cacacaaatc cttaaagaat ctggttttgg tacaaaagcg gctttaatcg 1609321 ctaatattgg aaatgggctg atatcagtta ttgcagttat atttgggatt tggctggtcg 1609381 gaaaagtgag acggcgtcca atattattga ttggtttggc agggacgact acagcgctcc 1609441 tattgattgc gattttctca attgtgcttg atggatctat ggcacttcct tatgtagtgc 1609501 tttctttgac cgttttattt cttgccttta tgcaagggtg tgtaggacct gtgacttggc 1609561 ttgtcatagc ggaaatattc cctcaaaggt taagaggact tggttctggg ataagtgttt 1609621 ttttcctttg gatattaaac tttgtgatcg gttttgcttt cccgatcttg cttagctctg 1609681 taggtttgtc ttttacattc tttatatttg tggctttagg tgtattggca atcggttttg 1609741 tgtacaaatt catgccggaa acaaaagggc gtacacttga agaattagaa gagcattttc 1609801 gttctcgaca cgatcataat actcctgaac aatcagttat tgaggtataa atatgttgaa 1609861 aatctctctt cttataggag ggattttttt agtttcagaa aaaacaaaat ccctctggta 1609921 gagggatttt gattcagcat tttaagatgt tctacacgta taatactgga gttgatactt 1609981 taaaaatctc gccatctctt atataaaaac gagggatgcg gcggcttaat gtagacacga 1610041 cttcatagtt aatcgtattg agcatttcag ccacttcatc aacggaaatc tcggctcctt 1610101 tttgcttacc gtaaatcacg acttcatctc cttgtttacc ttcaccgttt tctcctaaac 1610161 tgaccatgat catatccatt gttactcttc ccgccactgg cactcgtttt ccgcgatgaa 1610221 gaacaaaccc gcgattggaa agggcacgag aatagccgtc agcatagcca atcgggagtg 1610281 tagcaattac ttcattaggt tctgcgatgt atgtagcacc atagctaacg gttcggggtt 1610341 ctgtccgcat ggttttcaca taagcgatgc gtgcctttaa acttaacgca ggttcaagct 1610401 taacgagatt tagttgttta atataggctg aaggatataa accatataag ccgataccta 1610461 aacggatcat atcagcgcta aattccggaa atgcgatagc tgcagccgtg ttgcacatat 1610521 gcacggtggg cagctcaatc ccctgttttt ttaaaaagct gagaaaactg atgaattttt 1610581 catgctgcag ctttgtgagt gttgtgtccg gttcatcagc tgtcgaaaaa tgtgtgaaaa 1610641 tccctgtcca tctgaggaat ttacttgcct ttaaggcttt cactacctct aaaagttctt 1610701 cctttgtgcg tacacctaat cgtcccatgc cggtatccac gttaatatga atggccagcc 1610761 ggttagcact cgcttctttt tccaatatct cgtttgcttc tttcatccaa tcaacctgaa 1610821 atgctgataa tgttatattc caagctgctg acttctttac acaactaagg gatgtaaaac 1610881 caagcacaag gataggtgct gtaatcccag ctttacgtaa aacgattcct tcctccacac 1610941 tggcaacagc gagctcactc gccccgtgtt ccagtgcatg gcgtgccact tctatagacc 1611001 cgtggccata accgttcgct tttacaacag ccataatttt gctcttatgt ggaatatgac 1611061 ggcggatcgc tcgcaaattc tttttaacgg catcaagatt gacttcgatc caaacttctc 1611121 ggcaaagctt tatcatcaac gcttccttcc ttcttatgga ttataaatac cacctattgc 1611181 cgcaagaata aatgttaatt gttggatgat tcgatcttat tttattcaac tttatttgaa 1611241 atcattcaac agcaaatcca tgtgatacga gaaggtgcct atcaatgttc gaataatagc 1611301 aagtacggga tacatgaggc ttgtaagtgg ggtgttaatg gatgcggcga ccgaggatta 1611361 caaaaatgat tatttgtttt gggacatttt tttctaaggg tagatgataa cgagaaatct 1611421 aatcaggaaa tacttaccgt tgttatgaac attgaagaac cttttaaatg agaagggctg 1611481 aggaaattct gtaaaagata atcggttgaa aaggcagtcg attccttgtt ccataaacct 1611541 aacatcagag tatataatta tactcgtatt cacaaaaatc gtttaagtaa ggggtataca 1611601 tgaatagggg agttagtttt caaataccga atgaatatgg aaattttcta tggagaatac 1611661 tgcagccggt agaaatagct aattataggt ggcaaacgag tggggaatct tattttgttg 1611721 tagaaggaga gctcgatgat gaggagcttt ttcatgacta cgaaattgtt gagggggcag 1611781 tttttgagca acaattaaaa acgaatcagt actataccat tttcgttgaa ctgaaagcat 1611841 ttccatatgg aaaaatggtt aatcaagtca atacatatga agagtttgct gacagtgatt 1611901 gcgaacttgt ccttttgata gcagataata gctacgtttc gatttactgt aaaaacaaaa 1611961 atatcattga aaaactttac ttcaatgctt tacagcatga ttttgaagac gttcaattta 1612021 taactgatga aaatgacaca agaacaagcc ttactgtatg atactcaata aaaattaaag 1612081 gagctagtac atgacaatgc aaattaaaat caagtatcta gatgaaacac aaacaagaat 1612141 cagcaaaatt gagcagggag actggattga tcttcgggca gctgaagatg taacaatcaa 1612201 aaaagatgaa tttaagcttg tcccattagg tgttgcaatg gagctgcctg aaggttacga 1612261 agcacatgtc gtccctcgtt caagtacata taagaacttt ggcgttattc aaacaaattc 1612321 aatgggtgtt atcgatgagt catataaggg agacaacgat ttctggttct ttcctgctta 1612381 tgcattgcgt gatactgaaa ttaagaaggg tgatcgtatc tgccagttta gaatcatgaa 1612441 gaaaatgccg gcggttgaat tggttgaagt cgagcatttg ggaaacgagg atagaggagg 1612501 actcggttca acaggtacga agtaaacaaa ataaatcctt ggctgtcttc atgctgtgtg 1612561 attgatcaat ggaggtttca gccaaggtac atataaatat tatgtataaa atgaatattt 1612621 taatacgaag gatttaatta aaaacaaagt ttaaaaaggg aagttttgaa aaagtgaaat 1612681 agtaataact aaagtcgata aagaacctaa agatgtcaaa gaaacaattt ttctggtgct 1612741 ttgctttttt gaaggtttac ttagctcgtg gataactgcc ccccataaaa gcatggatgc 1612801 taaaattata atacttatat acataaagat gctcctttta ttatatttac agtttttaca 1612861 tttttatcga ttttaccaca tttaggattg agttgtcgat gaaacaagca tctctataaa 1612921 gaaatacttt tatctaaatt tttataaata ggggaaggca actaaaaact agtaatgcca 1612981 ctaataataa gccaagttaa atgacttgtg ttcattaata attgaatttt acagcagcca 1613041 tgagcacaaa aaaatctgag ttcgtcgata aatatcataa aaaagccccc ggtatgtcgc 1613101 cagggaataa atagacgttt aagagattta gtgatgtttt ttatatgatt cgacaaaatc 1613161 ataataatga tcatcgtcat cataatactt tttttcgtaa tgataatcgt gatcatcgta 1613221 atacttttta tcatggtcat catacttttt gtcgtaatca taatgttttt tatcatgatc 1613281 ataatacttg tcgcaatcat aatgcttctt atcattgtcg taatactttt tgtaatatgt 1613341 ttttttccaa gtataatact cttctttata ttttttataa taacccaatt aaattcctcc 1613401 tttatgttat tcgaatttaa tttatgaagt ttaaatgata tggtatggtc aaatgaaata 1613461 agaatagtaa aaagaggctg tttaaaacac tttctgaaaa acaaaacgga tagctgttta 1613521 tgaaaataag agcgagagag agcactcaat cactgtaaaa taatagtaaa gtgtatagag 1613581 agattagtat acgtaaaaag ggactttctc attgaagaat atttgaacgt tatggttaag 1613641 attcaagagc tctatgatgt gatttttcac actgcttttg aaggatttag agttagacat 1613701 caaaaacaaa cagcaaaacc ggctagaaac agatcatata aggaatgaac cgctgccaaa 1613761 tatcataaaa aagttgttaa tgatcaaatg aatgaaatta gagagaattt attttaaaga 1613821 aagcccaatt gcacatggac aaatgacaat tgatattgag gtaaaataca atgcattaaa 1613881 tcagaaaaag ctattggagg atttaatgtg tttagacaat ttccaatttg gtatacacaa 1613941 acacctgact atttgaattt ttatgtaccg caatatcaaa ccatttcgta taatcctcaa 1614001 caatgttatc aacggtgtat gtaccaaact ggcggtaact atgagctatg tgacagacta 1614061 tgttatggag aaatacaggt gtaaaagagg gggattaact cctctttaaa cacacagtga 1614121 gtggaataag atcctcactt tatctgcaag tgcttagtat ttgcgataat attgcattcg 1614181 taataaatta tgcttagcaa ctgaaaatga aagaaggata tgaatagtca tgacgcaatt 1614241 cgataaacaa tacaattcaa ttataaagga tattatcaat aatggaatct cagacgaaga 1614301 gtttgatgta agaaccaagt gggactcaga tggaacaccg gcacatactc taagtgtaat 1614361 cagtaagcaa atgagattcg acaactcaga ggttccgatt ttaacgacaa aaaaggttgc 1614421 ctggaaaaca gccattaaag agttgctctg gatttggcag ctgaaatcta atgatgttaa 1614481 tgatttaaac atgatgggcg tccatatttg ggatcagtgg aaacaagaag acggaaccat 1614541 cggacatgca tatggatttc agctggggaa gaaaaacaga agtctaaatg gagaaaaagt 1614601 ggatcaggta gactatcttc ttcatcaatt gaagaacaat ccatcttcac gcagacacat 1614661 tacaatgctg tggaatcctg atgaattaga cgcaatggcc ttaacgccat gtgtatacga 1614721 gacacaatgg tacgttaaac atgggaaact ccaccttgag gtaagagcac ggagcaatga 1614781 tatggcattg ggaaatccat tcaatgtatt ccagtataat gtgttgcagc gcatgattgc 1614841 tcaagtgact ggttatgagc ttggtgaata tatctttaac attggggatt gccatgtgta 1614901 cacacgtcat atagacaatt tgaaaattca aatggaaaga gaacagtttg aagcacctga 1614961 actatggatc aatcctgaag tgaaagattt ttatgacttt accattgatg atttcaagtt 1615021 aatcaactat aaacatgggg acaagctttt atttgaggta gcggtttaat gctgcctttt 1615081 tattgtgcag tgaatagata gcaggtatcc taatttcatt aagcaatctg gaagatgaat 1615141 aaaaattgaa ggacaaacac gtataataca taaaaaagat taactctaca gttaatcttt 1615201 tttattcaga agaaaatatc ctaactttga aactaaatac aaagtaaaag caatcattac 1615261 agttctagat attacaattc catgaatagc tagatcatat ccagcaggta tcaacgcatt 1615321 tgtattacac ataaaatata tagatattag aagtgctaca ataactaaaa tcattccaaa 1615381 aagacttgtt ttttcatatt tcataccaat ttccaccctt attaaagtta ggtttaaaca 1615441 aaagagctga agaaacgaac tatgaccagt atgctccaag gaaaaccgcc agacaatgct 1615501 ggcggctttt tgctgcttcg tttatttatt aacagagatc gtaacgttat ttcctgcaac 1615561 tgaaaccttt gcgaaatcct gtgtatctac cacaggagtg acggctttat tgtcgatagt 1615621 gatgttgtta aaagaggtcg aaaaggttgc tttgatcgca tcacgctggc tttcatacga 1615681 aacagccgcg gtagcaagtg ttttccattt tgaaatcgtg ccgatgttgg ttccttgaat 1615741 ttctgtgata atccgtccgg tgtagccgtc attgttcgtt ccccaaaggg tcatgcgcgt 1615801 attgccgctt aaatttttat agattgtcat ttggactgtg cttccagggc ggaagccttt 1615861 attgtatgtg aatttgtctt ttccttcgat gtacgtttct tcatttttgg acccaacctt 1615921 catgaggggc ttccagacgt tgtattgttt gctgtactga agcccgatat cggcttcagt 1615981 tccgcttgtt gccctaaagc cagaataaat atagggagta gagaccgagt cgttgttttt 1616041 gacagtttca ggaagcacga ttttagctgt aaaaacggcg cccgtactgt tcaggtagac 1616101 acggccgccg attccgttag gcagctcgga tgctgctttt gcgacttgag cgtctgccgc 1616161 gggtaaacct ggtatacctg atgaaagggt tccgaaaaga actgctgttc ctactgcacc 1616221 tgcaatcaat acttttttca ccaaaattcc cccttttgat agtggtttcg ccatttatta 1616281 taccttattt tggaactgga tttacgtata taaatcgaca aaatatttca ttttgaatga 1616341 tgtaaggtcg aaacgcttcg ccaatctgaa agctatatac ctttatcaga ggaaagaatg 1616401 agatcacatt cgttttaacc gatttgaaat tttcctcaaa ataaaagtac aaatgcttaa 1616461 agaaacgatt attaaaagaa tgcccgctat cgtttccaag cctgtaaaaa agaggtgacg 1616521 tttcatcaat gtctgtcctt gtaaaatgat aaaagcacag ataccgacta agaaaagaaa 1616581 acaaatactt aggattgcta acgctttacg tgagtatgtt ttcatttcat ctttaaaata 1616641 cagcaatacg aaaataaagc agataacatt ggctattgtt ctaatcacct caaagctttt 1616701 catgacaact gatataaata gacaaagtaa aatgagataa aatacgatgt ttctatacaa 1616761 aaaacctctc cttttatgta ggatcctcaa agagtttata aaagtttctt tgtaactgca 1616821 ataaattgaa tgcgctcact tatgaactaa ctaaactatg tactaaatat tcactattct 1616881 ttttcagatt cagtcaccaa ggttttcata gaaagggaag cttcagaaat atacatatag 1616941 tgcacaaaca aaaaagaccc ggcaatagcc gggggaaagt aaaaacgagg agatgttaat 1617001 ggcgtttagt agtgtttttt atgcttttta tactctacaa cataatcata gtctttttta 1617061 tcgtgatcat aatatttttt atcatagtca tcatattttt tgtcgtaatc acagtcataa 1617121 tcttttttat catattcgta atacttctta taatacgttt ttttgaccgt ataatactct 1617181 tctttgtatt ttttgtaata acccatatat actcctcctt tatttttact acgctttatt 1617241 atacggcgag tagattttgc ggcttggaca gttaaaatca tagaaggaaa aaagggctgt 1617301 ccaaatgata gaaaaagaca gatgacacaa aaacaaatca aaataaagag ccgatttttc 1617361 atcggcccaa acgatttatc ctacatttgt ttgtcttctt tgttttctga gtcatttttt 1617421 ctgatatcct gagtcagtcc gcttgttgct tgtttaaatt ctgataaggc ttttcctgct 1617481 gcacggccaa gcgccggcag tttatcaggc ccaaatacta aaaaacccac aaacaaaata 1617541 acgagtattt ttgtgaagct taattccata tccttttccc cctgattgaa gtacaacctt 1617601 ttaaacaaat tataagagat agcagtacaa atgggaatgc atttattttg aacattttaa 1617661 aaccagcaca aagacggatt cataaaacgg ctgctgctga atataatgtc caatgccacc 1617721 tgcctaagaa gcaggaggca ggctggatca attatgtagc tctgccggaa atgatacaaa 1617781 cgtagcggct atcattgaca tagaggagtg gtgtagctga tgagattcac taaggtagtt 1617841 ggatttttgt ctgttttagg gttggctgcg gtttttccat taacggcaca agcagaaaaa 1617901 gccggaactg cgggggctgg agagtgggat aagttgggga cttacacata tacttactca 1617961 agtccgacgg tatactcgac cggaggagat tttagagtgt gcctttcagg aagcactcct 1618021 ttttctgttt cactgcactt atatgaggat gatcccggtg acaatcctga tgattatgta 1618081 ggggcaaact atttttcacc cggagaatgc cacacctttg gcagtattgg aaaatttgta 1618141 gatgggagca ataacaaggc cgagttcttt gttaccgatt actctggtaa atctaaaact 1618201 gttacgtttt atgattgatg gactcaaatt gtgaagtata acccttggaa aaaaacaaaa 1618261 aagagagata cctctctctt ttttattctt cgacagcctt acgaagccgt tcatttacaa 1618321 tgccagtcca gccgccatcc atcttaccgc gaacgacgga gcttttctcg tttgctttgc 1618381 cgatcacttc attcggctct ttccagccgc tgtgaataag ggtaaaccct gtcttttccc 1618441 ccaagtcttc taattgaaag gtaacgaccc atccttctgt atcccattca aaagaaagtt 1618501 cagttggagc ttgaacagcc aaaactttac aaggggacgg cccaaacggc gattgtaagt 1618561 gaaattcttg tccttctttg agctgaaagt cattgggcat aaaccacttg gcaatgcctt 1618621 ctgaagtaga gactgtctcc cagactttct gaatgggagc ctccagagta atgctttttg 1618681 taatatccgg taatgcattt tcgttgtttt gagccatttc gtttacctct tgacatatga 1618741 tgttttttca attcaatcat ataataacta ataagatcat gtccatagcg tgcattattt 1618801 atgctagagc tgctgttgaa cagcgtgtca gtcgccagtc tgatctgtga atgggagaat 1618861 tctgcatgcg cgaaaaagag agagaggtgt atgttgtcat ttcgttcatt cttgtttgca 1618921 gccgcaactg ttatgtttga actgggattc ctgttcagcc aatttatttt gcgatttttg 1618981 ttttaatagt aaatgagcca ttttctaaaa caggaggttt tttatgcttg gaaaaatcaa 1619041 agcagccatt gataatagtc cagggaagcc ggccagaatt ttagttagtg aaaaagcgtt 1619101 tcagcaatta gaggaagaaa tgcgctttgt ttacgtttcc aaaccgaaaa cgataatggg 1619161 gattcctgtg gaagtttcag atcaggcaga aagcttcaag ctggaatttt agttttccca 1619221 gactgctaaa aggctcattt tgtgttaatt atgcaaaatg gtcaggttga tttctttaaa 1619281 agcatgatga aatgttcatc atgctttttt attgagaaaa aagacgaaca taaaaaatag 1619341 gtatacggga aaaataatcc tattagagag aggggaactg acagatggat aacatgatat 1619401 caacacttac tgactggaat gtgtggtttc aagcgttagt agtatttctc gttccatatg 1619461 taatctataa agtgtttact tggattcatg tataagaagg tgcaatgatg aggtggcgga 1619521 acaatcagta caaaacacag aagcagcata aatcagatta ttcgacagct gaaaagcagg 1619581 atcaggatgt gttaaccggt aacatcggat acgacttaga acatgtaaaa agaaaaatag 1619641 gacataacgg ggacgttcat ttccgtgagc ttgaaatcac tcaattacat gtgaaagcgg 1619701 cattgatctt tgttgaagga ctgtctgatc aggacttgat taataaagga ctatcagtgt 1619761 tagtcatgaa tcaacctaat caggtaagcg atgaaatttc tcaatccggc aaaggtattt 1619821 taacttcgaa acagataaaa aatcaaatcg tatcaatcgg tgatgtcata gattcagaga 1619881 aaatcagtga tatcgtgttg aatgttttca tgggttcgac agcgcttctc atcgatggaa 1619941 taccgcaggc ctttcttctg ggaactgtaa aaaaacaaaa tcgaagtatc gaggagccgc 1620001 tttcagaagc gcttgtcaga gggccgcgca caggctttac agaagagttg agtacgaata 1620061 cagctctttt gagacagcaa ggaaaaaatg atcaattaac attgcagaga tttgaagtag 1620121 gaacacgatt aaaaaaggat ttaattatcg cttatatgaa tgacattgca gatccaaaag 1620181 tagtcgagga agtaagaaaa agagtgagag ggattgagat cgatcatttg ccggagtcag 1620241 gctacgttga acagttaatt gaggataatt atttgagccc gttcccgcaa gtacagagta 1620301 cagaacgtcc tgatcgcgtc ataagcggat taatggaagg aagagtagct attctgcttg 1620361 acggcactcc gtttgctttg attgttccag tcactttcag catgatgctt caatcgcctg 1620421 aagattatta tgaacggtgg ttcccgagct cgctcatcag attgctgagg ttcatcgcag 1620481 caatgataac gttattcgca cccgctttat atatatcatt tatttctttt catcctgggt 1620541 taattccgac caagctggcg atttcaattt ccgggacgcg ccaaggtgtt ccgttcccat 1620601 ctctgattga agccttattt atggaagtcg cgattgaaat tttaagagag gcggggcttc 1620661 gtttgccaaa accaattgga cccgcaatag gcatagttgg cggattaatc atcggggaag 1620721 cagctgtgca ggcggggatt gtcagtccaa tcatggtcat tgttgttgcg ctcacagcaa 1620781 tttcttcatt tgccatcccg cattatagca caggtatagc acttcggatg cttcggtttg 1620841 gcgcgatgtt ttgtgcggcg gtgtttggat tgtttggagt cattatgtat tatctgctgc 1620901 taagcagcca tgtcgtaaag ctaaagagct ttggtgtgcc atacgcaagt ccggcagtgc 1620961 cctatcactt aaaagattgg aaagactttg ttatcagaat gcctctttta gtcatgaagc 1621021 gccggcctaa aatgatgaat acagataata caaaacgggt gaagtgatga actcgacagg 1621081 atggtgataa agtctcatgt tcagcccaac cagtaaaatc acaaccgctc aggcaacgat 1621141 tatcatcatt aattatatgc ttgctgccgg agttcttacg ctccctcgga cagtaacaga 1621201 acaaacacaa tctcctgatg gatggatttc agttttatta ggcggggtcc tagcggtaat 1621261 agccgggatg attatagcta aattaagcca gcagtatcct aaggagacct tttatgaata 1621321 ctcccgacat attgtaggaa aatggctcgg gcatctgatc agtattgttt ttattactta 1621381 ttttctggca ctcggtgcat ttgaagtcag agtcatgtcc gaaatcgtgg atttttttct 1621441 cctcgaaggg acaccttctt gggccatcat tatgacagtt ctttggattg ggctttattc 1621501 aattacacaa ggcctagatc cgattgcacg gctttttgaa atgatttttc cgattacggt 1621561 catcatcttt ttaacgatag ccctcatgag tttaggcata tttgagatca acaatttgcg 1621621 ccctgtatta ggtgatggaa tcatgccggt tcttagaggt gtaaagacaa cgaacctttc 1621681 atttacatgt tcagaaatta tgttcatttt agtagcattt atgaaaaagc cgaaaaatgc 1621741 ggtgaaagca gttgtgatcg ggacaggcgt tgtgaccagt ttttatatga ttacgatgat 1621801 tatggtcatc ggtgcactat cagttgaggg agttgtgacg agaacatggc cggggcttga 1621861 cctgatgaga agttttgaaa tacctggttt aatatttgaa cggtttgaat catttctgct 1621921 tgtgatttgg attatgcagc tttttgccac gtttattatc actttttatg cagcttccct 1621981 gggagtctca caagttttta aaaagaaacc cctttcatgt atgtttgggc tgcttcctgt 1622041 tatatatatc ctctcttgca tgccgaaaaa tgaaaatgac gtctttatat tgggcgatac 1622101 ggtcagtcat atcgctttgt atatatttgg cgctttgccg attttgctgt tagtcatttc 1622161 gaaatggagg aaaagaggtg aaaagtaaac taaaacgtca attgcctgct atggtcatag 1622221 tatgtctgct gatgatttgc gtaacaggat gctggagcag tcgggaaata gaagatctgg 1622281 gtctcacatt cgctatcgca attgataaag gaaaagaaac gaacactgaa aaagagttaa 1622341 aagaagaggg cgggagctat ccgaaaaaag acaacattac gctgacctat caatttgtta 1622401 atgaaaaagc ggcaggcgcg ggcacaagcg ggggaggcgg tagcggacaa ggagcgcaaa 1622461 aagcgtacat taatataagt gaaacagggg attcattaca gcagatcgga agtgaggttg 1622521 cattaagacg ggaccgagaa gtgtttagcc cgcatttaaa agttgttgtc atgagtgaag 1622581 atgtgctgca cacatttcct atcgacgaaa tgctggatca attttttcgt gataatgaaa 1622641 tcaggctgag ctgtcttgtt ttatctgcta aaggggaagc aagagacgct ctccagctga 1622701 aagagaacgg agaaattccg gcatttcggc tgattggatt aggtgaaaat gaacataaag 1622761 tttccagaat tcttccccct atgacactcg cgaaactaat tggaaaactg cattctggca 1622821 gcagcttttt actgcaaaat gtggttgcgg cgaatggagc ggtcaagtat tccggagcag 1622881 ctgtaatcaa cggaaaatcg aaaaaaatga taggcacctt aaatgaatat gaaactgagg 1622941 ggattacatg gattagagga gaagggaaag gcggagttgt caaaagtcat gataaaaaga 1623001 gccaacagac gttagcgtac gatatcaata aaatcaaaag cagaattcag ccaatcgtaa 1623061 aagggaaaga tatttcattc catgtcgata ttgaatcaga aggcgatttg gttgaaaact 1623121 ggaacacaaa agaggcgttg gacacccagt ttatagatcg tctcgaaacg actattgaaa 1623181 acgaggtaaa gaaaatagtt ggtcaggtat taaaaaaaat tcagcatgat tataaagcag 1623241 atgttgcggg ttttgatgaa tcttttagac ttacatatcc tcacttatgg aaaagggtga 1623301 aaaataactg ggatgacacc ttcagtaaag ccgacatcac atacagtgtg aacgtcacaa 1623361 ttactcattt cggcacggtt aaaactcagt aatgaatccc aaggaagaga aggaaacctc 1623421 tcttctcttt tttatgcatt tattaggata aagatacttt ttttggagag atatacactt 1623481 ttcaaatcga ccaatatgct aatataggaa ttgcttgaaa tagaagggag aaggggctgt 1623541 gaggcagaaa ccgatttatg tagaaatcga aatgaaatct gatctggata cactctggga 1623601 atatacacaa aacccatcac tgcataagga atgggatctc cggttttcaa atattacgta 1623661 tttgaatagt cagccatgcg aaaaacagaa gtttctttac gaaacaaggg taggctttgg 1623721 attaaaggtg tcaggtacag gagaaaccgt cggtgttttc aacaaatgtt catctgaaag 1623781 gtcttcttca ctggcttttg gctctgatca tccattatct ctgattcggc atggaagcgg 1623841 ctactggaag tatatacaga gagaaaatgg gaaaatgacg tttttaacac agtaccaata 1623901 caaaacagcc tacggactgc tgggaagatg gattgatcgt ttattatttc ggccgctgct 1623961 tggctgggcg actgcctgga gctttgatgc attaaggctt tgggtagagc aaaataaaca 1624021 tccgaagcgc ttcattcgat ctgctatcat ctatgtgttc atgtgtctgt ttttcagcct 1624081 gttttggttc tatcaaggct ttgcaggtgt taagacaagc atattgacag gaacagcgga 1624141 gataggctta gctattttgt ggctgcttcc tttaaaaaga aaatggatca ttcatggtgt 1624201 ccaggcttgt atttttgctg ggtttgcttg tctaggttcc gaaatattca tgtgggttct 1624261 attgagtgtg ttttccgctg caagcggcgc tcttagcctg cagctcccca gtgccaggcg 1624321 cacaaaacga aagagaaaga agtgacattg tgagttcgat ttatgaaaaa tcaattatta 1624381 actatcattt gctgcatccc aagctgcaga aacggtacca attagacggg tctcatacat 1624441 tcagcgggac gggaacgatg tcagaaataa gcggaggctc ttttctggtt agaatgctgt 1624501 taaagctggg tgtttttttc agatgcttct tttcagaaag aggcaaagac attccattta 1624561 caatacaaaa tagaacttgt cttttgaaat cgcaacatac aggaatagaa tggaatcgta 1624621 catttttctt taaaggcaaa aaacgtttct ttgatgcgtt aatgatatat gacgagaaag 1624681 aaaatagaat acttgatttc ttcggcaaac ctcatctgct gctgtctgtt ttgacgttcg 1624741 aggcatctct tgacggctct cttacgatca catcgggaaa gcaatggcta ttgatatgcg 1624801 gaaaaagaat cccgctgccg aaatggctga ccggtacatc cgaagtttgc gaaacgtttg 1624861 atgaaaaaaa gaattgtttc accattgaag tgcatgtgca aaatacaatt cttggcactc 1624921 ttttctttta taagggaacg tttcaggagg aagagagaga atcatgaaac gaaatggcat 1624981 agtcagtgcg ctttgtttta ttggatttct tgcagcagaa gcaccggata tttcagtggc 1625041 agaggcactc gttttgttat ccattctatt tttcgtgccg ggaatttttc cttttgtttt 1625101 tcgtcaatct ccggttcgtg ctgctcagtt tatggaaaac gggctaatcc agtgctatcc 1625161 tgtagccgca ttctttgcgg tgctggctct agtgacggag gttgggggtt tcgcacttat 1625221 ctggtggatg tacacagttt ttaatgcatt gtatgcgatc ctccgccttt gggaaacaaa 1625281 gatacataga atcgaagaga catcagtttt gttcggtctt atttatttgg cgggaggagg 1625341 attttggttt tttgcttatg ctgcccattt gcagatcatg caatttggcc ctctcatcat 1625401 tttgctgact gctgtccact ttcactattc tgcttttctg atcccgatct tcaacggttt 1625461 actcggcaga accattagaa aacatcggat gttgtacagt tggataacat gggtgatttt 1625521 gctttcgccc cttcttatcg cactgggcat cacatattca aaaacacttg atgtcattgc 1625581 ggttagcatt tatatggcgg cgatttatct tcatgcattt ttggtgttca cggcagcttt 1625641 tcgcaccaag acggggacat ttcttattcg gctttcttcc gctgttttaa tgataacgat 1625701 tgctttctcg atgatttatt catttggtgt ctttcggcaa gaagttacat tgaccatcaa 1625761 tcagatgatt tggattcacg gttttgtcaa cgcgtttggt gttatcttgc ccgctctcat 1625821 agggtggaga atagaggatg cgaaaccttt tgatgcagac agtgtaaaga cattcagccg 1625881 tatctacgga aaaagaaaga ttggagaaga atttttagct aacattcaag ctgaaaataa 1625941 cgctcggtac agcggacttg tggatgatat gggcagcctg cgttcaaaag atttttcacc 1626001 agaaaaactg gcgccgctca ttctttcgtt ttatgaacaa accatcgaat acaatattaa 1626061 agcaaaagta acatggagca cgtggtttcg gccgcttgca attatttacg aatggttcag 1626121 cagaagaatc ggccaaatac atctttcgac gaaccctgac tggtatagga tgtacagcaa 1626181 gataaaaggt gttcattcga aaaaagacgg aagggaaaga gtacgtgcct ggattagaac 1626241 aaatgaaaaa aacgaaacca tttttaccgc tctttattca gtgtatcgtt caaatggaga 1626301 ggggtatatg aatatttctt taccgcttcc attcagcagc atgacaggta ttttaaaacc 1626361 atatcatcat caggagaagc tggttttaac aagcaggcgg agaaaaagca gagcggggga 1626421 tgaggggatt tatctgcaaa caagagcggg aacttgtccg cttcctttat ctgaaacctt 1626481 tctgatagaa gctgtacatg acaacaaatt aaccgctgtt catcatatgt ggctgtttgg 1626541 aataaaattt ctaactgttc attacagcat tacacatatt aaccagccta ttgaaagaac 1626601 ctaacacaaa gaagaagctt cgtctgccag ttgtaatgag atgaactgtt ttaaaattct 1626661 gcaccgcatc aagacaggaa aggaagggtt tatggtgttt tatatcagtt tatttctgat 1626721 tctttggctg gctgctgggt ttgcagtggg aatgaaacaa gtgtatgtcg atcagctgtt 1626781 tgataaagct gtgatcgaaa gactggaaaa agaagcgaat gatcatggac atgctgaccg 1626841 gatgatcaaa cagcgcgtcc tttatattgc agcagtgaca gtaagcgggt ttatttctgt 1626901 ttattatgaa atgaaaacaa tcccgcaaag gcgaaacata agaaaaattg aaaaaaacat 1626961 catgaaatta aatcaagcaa aaaaacgaag aatgaagaga aaataaaaag tgcacaggcc 1627021 aaagggcagg tgcatttttg ttttgtatgg aaaatggggg aggtggtgcc agcttacttt 1627081 tcataaattc aaaaatgaga agaacagcgc ccgggctaat ggtatataat attgtgaatt 1627141 taacaaaaat ttaacaagga ggacgagaga attcgtgcta aagcctcaaa gagacctaca 1627201 ttctgttgat ttggacttag aggcggagta gatgaaaccg gccaaagtat ccctgctccg 1627261 ccgtttgctc cattccttga agcatgttga ttgtaacata gccaaacgtt ttccatcaac 1627321 tattaaaatt gtaaaattat tgatgatttt tatggtgttt actccgattt cttcaattta 1627381 tgctgaagat gtatatcaga attttgagga attaaaaaac aatgaagatc cttctgatta 1627441 tggcgttgtt acgaaagaaa ccggaagccc tgttcttgtt ttagctattc acggaggagg 1627501 tattgaaggc gggacaagtg aagtagcgag agagctcagc aaagagtact cgatgtattt 1627561 atttgaaggc ttaaaatcgg caggaaactc agtcctgcac attacgagca cacactttga 1627621 tgaacctcgg gcccttaaaa tgacgggaaa tcatgaatat gtcatttcat tacacgggta 1627681 cgcagaagaa gatcagcaga tcgaagtcgg cggtacagat cgcgtaagag cggcagattt 1627741 agttgagaaa ttgcagcatg ccggttttcc tgctgtattg ctcaatatgg accatccgca 1627801 tgcgggcgtt agtccgaata acattgcaaa taaatcaaaa acaggtttaa gtattcagat 1627861 agaaatgagc acagggtttc gaaagtcttt gttcggcatc ttttctttaa aaagcagagc 1627921 tgttactcaa aatgagaggt tttatgagtt tacagaagtg atgttccgtt ttctcaaaaa 1627981 tagctactga aaaataggag gcgataagac agcctcctat tccttatgct tctctttcgt 1628041 ttcgggaaac agctcgtccg cggcttccgt ttgatactgc aacgtgttat ctctcgctga 1628101 cagttcattt cggaaatttt catcaagcac atttttcagt aaataccgat gaaaaaagta 1628161 ttcaaaaaca gtaagacagg cagcggaaag gagagccgct ccaaatggtg agaaatcgtt 1628221 tcttgtttgg gttaaaacaa atacccaaag aataacgaat gaaaggccaa agtcagccaa 1628281 tgaagctgta atattgtttg ttctgggtaa gacgagcatg tcaccagaaa gataggaaac 1628341 aaaacctaag aaaagtgcaa taaacatcac acttaaaaag gatgcgtgat agactctgtc 1628401 caaaatcaca tataaaaggg cgagagtgaa agcaatcttt gaagcaagcg caatgatatg 1628461 tttcatttga ccacctaaat tgttattttt tgaagaaaat tcttgggcgt aaacaaatga 1628521 taaataatgc aattcaaaac cattcataat ggtcatgtta ctattttaaa cagtccgttt 1628581 ttgtttacac tggtattttt ttcagctgta tgaaactttc ttatgaaaaa agtcgtatat 1628641 gtggatgatc agctttcaag gggggaatga tttgtggaga taaaaggaat caatcacttg 1628701 ctattttcag tttcgcattt ggatacatcg attgattttt atcaaaaagt gtttggtgca 1628761 aagcttttgg taaagggaag aacaactgca tattttgata tgaacggcat ctggctagcg 1628821 cttaatgaag aaccagacat cccgagaaat gacattaagc tttcttatac ccatattgct 1628881 tttacaattg aagatcatga atttgaggag atgtcagcta aattaaaaag acttcatgtc 1628941 aatattctgc ctggcagaga acgagatgaa cgcgatcgaa aatcaattta ttttaccgac 1629001 cctgacggcc acaaatttga atttcatacc ggaacccttc aagacaggct tcgatattac 1629061 aaacaagaaa aaacgcatat gcacttttat gatgaaacgg ccttttgata gcacaaccat 1629121 atttcatata aggttaaatt taaagaaggg tgttggtgga gactttatgt ttggggaagg 1629181 tttctacccg acttgttcaa cgatgccata tcttttgaac tgcacaagtg attgggtgaa 1629241 ggtgaaattg aaatacacat tacattacat tttatatgaa gaaagcgagc tgttttatca 1629301 aatgttgaac taattaaact atgtactaaa ttttcagtat atttcaattg ctttgcccct 1629361 taataaatat aaaaccgcat ccttccacga cctaaaaaat gaaacgtttt taagaagatg 1629421 gcgtctaata ttctaaatgt tcatattttg ataaaagttt cctaaaggaa agaaaatttc 1629481 ttgacttcaa caatcttttg gtggataatt atggtgtaaa catgatgttc tttttcctcc 1629541 tattcgggct cgcacccaaa agtcagggcg agcctgcttt ttttgaacaa caaaccccct 1629601 ctccgtaaag gaagaggggg ttattttatg catctgatag atcaatagat taatggacgg 1629661 ttctgaacac gccaatcact ttccctagaa tgctgacatt ctgcaaaatg ataggttcca 1629721 tcgttgggtt ctcaggctgc aagcgaatgt gggtatcctc tttatagaat cgttttacag 1629781 ttgcttcatc atcttctgtc atcgcaacta caatttcccc attgttcgct gtgttttgct 1629841 gtttaacgat gacatagtcc ttatcgagaa taccagcatc tatcatactg tctcccataa 1629901 tctccagcat aaatacatgc tcgtctggag gaaccatgcg gtcagggagc ggaaaatatt 1629961 cttcaatatt ttctactgct gtaataggag atcccgccgt gactttcccg atgaccggta 1630021 cattaacgac ctggctttgc ggaatgtcta cttcttcatc aagaatttct attgctcttg 1630081 gttttgtcgg atctcgtctg atcagccctt ttgtttccaa acgggccaaa tggccgtgga 1630141 cagtagaact ggacgcaagc ccgacagcct ctccgatctc tctcacggaa ggcggatatc 1630201 cttttgattt aacctctgct ttaataaaac ggaggatatc aagttgcctt tttgatagct 1630261 tcgtcatttt tcgcacctca aaacgtcgat tttaagaaga ttatagcatg attttcctta 1630321 cagtacaaac ataggttcga aaaaacaatt gacagaaacg tttgttcgta tatactgaaa 1630381 ttataaaaat gcgaacaaac attcctgttg gaggttatga tcatgagtaa agaatctatt 1630441 atttttgtcg gtctgtttac agtgattttg agcgcggtta tccttatgct gtcatataca 1630501 agcagcggcc aagagcttaa tcagtatgtt aaaatagaag tccagcaagg cgacacactc 1630561 tggtcaattg ctgatcaggt agccgataca aaaaagataa acaaaaatga ttttattgaa 1630621 tgggtagctg ataaaaatca acttcaaacc tctgatatcc agccgggtga tgagttagtg 1630681 atcccattga aaaagaagca tcaggatgca tatgaattag caactgtaag atagagagga 1630741 aagagagata aaatgaaagc actcatttat gcccgtgtaa gcacaaataa agaacagcag 1630801 gaaacgtcat taaagcggca ggaggaggag cttacggcca ttgcagcgga gaacggcatg 1630861 gaagtggtca aagtgatttc agaaaaagcc agcggatatg aaatggatcg ggatggtgta 1630921 tttgagctgc tcgatgagat taagaacgct gatattgatg tcattttggt tcaggatgag 1630981 acaaggctcg gacggggaaa cgcaaaaatc gcactgcttc attgtattta tagagaaggt 1631041 gtgaaagtct atacaacggc tcatagaggt gaactggagt tatcggaggc tgactcaatg 1631101 gtcttggaaa tcgtcagcat tgtggaagag tatcagcgaa agattcacaa catgaaaatc 1631161 agacggggaa tgaaacgtgc agtaaaaaac ggttttaaac cgcaaaaaaa cttaaaaaac 1631221 caacatggga acagtggaaa agaaaaaata gaggtgccaa tctcagagat cgtccgcctg 1631281 agagcgaata aactgacgtt tgctgaaatc gcggctaccc taagagggtt tggctatgat 1631341 gtctctaaag caaccgttca ccggcgtttt caggaataca tagagaatga agagactgca 1631401 gagtgaatca gttgtaaaac tttttttgat ctagtactat atagacaaaa tgcaataaag 1631461 gagtttaaca tgatttcaaa cgcgaaaatt gccagaatta atgaacttgc tgccaaagct 1631521 aaagctggcg ttattacaga agaagaaaaa gccgaacagc aaaagctccg tcaagagtac 1631581 ttgaaaggtt ttcgttcttc tatgaagaac acgttaaaaa gtgtgaaaat cattgaccca 1631641 gaaggcaatg atgttacacc agaaaagcta aaaagagaac aaagaaataa caaacttcac 1631701 taatataaga ggaatacggc aatatcgtat tcctcttttg catatactat aatcaaaact 1631761 cttatgtgac aaaattcaac aagtttctct caaatttaag ctgaaacagt tgagaaaaag 1631821 tcgtcagaca tttatgatgt aagggtacaa cacataagga aggggatttt tatggataca 1631881 attgaaaaga aatcagttgc taccattcgc acactgtcaa tagacgctat tgaaaaagca 1631941 aattctggtc acccagggat gccgatggga gccgctccaa tggcatacac gctgtggaca 1632001 aaatttatga acgtaagtcc ggcaaaccct ggctggttta accgtgaccg ttttgtttta 1632061 tctgctggac acgggtcagc actattatac agcatgcttc atttaagcgg gtttgatctt 1632121 agtattgaag atcttaaggg attccgccag tggggcagca aaacaccagg acatccggaa 1632181 ttcggacata ctgccggtgt tgatgctaca acaggtccgc ttggccaagg aattgccatg 1632241 gcagtcggta tggcaattgc tgaacgccat ttagcggaaa catacaaccg cgattcattt 1632301 aacgtagtcg atcattatac atacagtatt tgcggtgatg gtgatttaat ggaaggtatt 1632361 tcttctgaag ccgcttcact cgcaggccat cttcagcttg gccgtctgat cgtactatac 1632421 gattctaatg acatctctct tgatggagac ctcgaccgtt cattctctga aaacgtgaaa 1632481 cagcgttttg aagcaatgaa ttgggaagtt ctttatgttg aggatggaaa caatattgaa 1632541 gaattaacag cggctatcga aaaagcacgc caaaatgaaa agaaacctac attaattgaa 1632601 gtgaaaacga caatcggatt cggttcacct aaccgtgccg gtacatccgg tgttcacggt 1632661 gcgccgcttg gtaaagaaga aagcaaatta acaaaagaag cttacgcgtg gacatatgaa 1632721 gaagacttct acgttccgtc agaagtttat gagcatttcg ctgtagctgt taaagaatca 1632781 ggtgagaaaa aagaacaaga atggaatgct caattcgcta aatataaaga agtttatcct 1632841 gaacttgctg aacagcttga actggcaatc aaaggagagc ttccgaagga ctgggatcaa 1632901 gaggttcctg tgtatgaaaa aggaagcagt ttggcatccc gtgcatcttc cggtgaagtt 1632961 ctcaacggac ttgcgaaaaa aattcctttc tttgtcggag gttctgctga cctagcggga 1633021 tcgaacaaaa cgactattaa aaatgccggt gattttacag cggttgatta ctcaggcaaa 1633081 aacttctggt ttggtgtacg tgaatttgcg atgggtgcgg ccttaaacgg tatggcgctt 1633141 catggcggtc ttcgtgtatt cggcggaact ttctttgtct tctctgatta cctgcgtcct 1633201 gcgattcgcc ttgcagcgtt aatgggcctt cctgtgacat atgtcttcac acatgacagt 1633261 attgcggttg gtgaagacgg tccgacgcac gagcctgttg aacagcttgc ttcactccgt 1633321 gcgatgccta acctttcttt gatccgtcca gcagacggca atgagacagc agcagcatgg 1633381 aagcttgcag tgcaaagcac tgaccaccca acagcgctag tgcttacacg tcaaaacctt 1633441 cctaccatcg atcaaacatc tgaagaagca ttggcaggag tagaaaaagg tgcatatgtc 1633501 gtttctaaat ctaaaaacga aacacctgac gctcttctca tcgcttccgg atcagaggta 1633561 ggtcttgcaa ttgaagcgca ggctgaattg gcaaaagaaa atatcgatgt ttctgttgtc 1633621 agcatgcctt caatggaccg ttttgagaaa caatctgatg aatacaaaaa cgaagtcctt 1633681 cctgcagatg tgaaaaaacg tcttgcaatt gaaatgggct catcatttgg atggggcaaa 1633741 tacacggggc ttgaaggtga cgttctcggc atagaccgat tcggtgcatc tgctcctggt 1633801 gaaaccatca ttaacgaata cggcttctca gttccgaacg tagtgaatcg agttaaggca 1633861 ttaatcaata agtaagcttt tgaaagagga tgagtcaaat catcctcttt ttcttgttta 1633921 tccgacaaaa atagtattgg ctgtttaaca gtaatagaca attctttctt ttcttctttt 1633981 gtataataga gagcaaatga aatgctgctg gaaaagggga tgaaaagatg gaacgtcact 1634041 actatacgta cctgatcaaa gaggaatttg ccaatcacta tttcggccgg gaatcggtta 1634101 tgtttgagct gtttcaagac tatcattgga caagccttga aaagcagcag tatgaaatga 1634161 cagagaaaca gattcaatat attacacaac caatcccgat tttacatatg catcagcggt 1634221 taaaaatgaa tttaaacaag acggattaca ggcagctgga ttatatttat agaatagctt 1634281 tgccgaaagc aaaaggccac gcgacgttta tgatgaagga gcacatgata gaaattgtgg 1634341 cttcgggaga ttacgaggca gaaacgatat tctttgaagt gttaagaaaa gtaagccctt 1634401 gctttttagc aatggatttc aattcgaagc gttacggatg gctaaatccg gtgaaagaaa 1634461 gaaattttgt ctaaaaccga agaaaaagag atgtaaatgt tgtataatag cttttggttt 1634521 agtacacttt aaactagaca acatgaagga ggaaataaaa tgactttatg ggttggcatc 1634581 ctagtgggcg ttgttgcatt gctcataggt gttgcactcg ggttttttat tgctcgtaaa 1634641 tatatgatga gctacctgaa aaagaatccg cctattaatg aacaaatgtt acgcatgatg 1634701 atgatgcaaa tgggaatgaa accttctcaa aagaaaatca atcaaatgat gaaagccatg 1634761 aataatcaaa cgaaataata cgtaaagatt atgatataga gaaacatggt tataaaataa 1634821 aaaaccctta tacgggtttt ttattttgca atcattcatc acccgctact gctcgaaggc 1634881 gctgcttttg atattgtatg agaagatggt caagctcctg actgagctct atcgtaatat 1634941 gagatgtcat tccgttcgcc atgacaattt gcagcagctc tgctcttttt ttttcaattt 1635001 cttttaatag atgctctcta atcacaggga tgtatccttt catacattag atcttcaaag 1635061 tgaatgttta tattatatcc atatttatac taattttcaa atgagaagga gtataatgtc 1635121 tcaatgtcaa attaaattat ataagttttt tctgaaaata gaaatccttc aagtgaaagt 1635181 gttaaaaaaa tgaaatgatt ttgtcataac ttgaaggaat gtcaaatcat gaagggatga 1635241 tgacatggga gacgtgaatt attttttgac attcggagcg gggtttttat cctttatttc 1635301 gccttgctgc ctgccgcttt acccagcttt tttgtcatat attacagggg tcagcatgga 1635361 cgatgtaaaa actgaaaagc tgctgctgca gaaaagaagc ttgtttcata ctttgtgttt 1635421 tttgcttggc ttttcagtca tttttattgc tttaggctat ggaacatctt ttattggcag 1635481 cctgtttagg gattatcacg atgcgattcg gcaaattggc gcgttgctta ttattttgtt 1635541 cggtttcatt acactcggtg tgttccggcc tgaggctatg atgaaagagc ggagaatcca 1635601 ttttaagcat aaaccaagcg ggtttttagg gtcggtctta atcggaatgg catttgcagc 1635661 tggatggaca ccatgtaccg gtccgatatt agctgctgtt atcacacttg caggcaccaa 1635721 tccgggctca gcggtgccat acatgatgtt atatgtactc ggttttgcgg taccgtttct 1635781 tttattgtct ttttttatca caaagctgaa gtggataagg aagaaccagc ttttcattat 1635841 gaaagctggt ggcgttttga tgattgtgat tggtgtgctg ttattcttta attggatgag 1635901 cctgatcatt attttgctgt cagatctttt tggaggcttt actggttttt gacggtaaat 1635961 tactttcgta ctactactaa tccttttgtt tttggtacaa taagactatt atctgtggaa 1636021 atcgattgtt ggaggggaat atgacaagag ttttagttgt agacgacgcc aagttcatga 1636081 gagtgaaaat cagagagatc ttggaagagg caaattacat aatcgcaggc gaagcggcgg 1636141 acggtgaaca agcagctgac ctgtataaaa aactgcgccc ggaccttgtg acaatggata 1636201 ttacaatgcc ggtgaaaaac ggcataaaag cgcttcgtga tatcttaacc tttgatccta 1636261 aagcgaaggt catcatgtgc accgccatgc gccagcaaag aattgtaacg gaagcaattg 1636321 agctgggggc aaaggatttt attgttaagc cgtttgagga aacaaaagtg ctggaagctg 1636381 taagccgcgt tatgggacat taaagtcatt tcttttcaaa atggtttttt ttattgtttt 1636441 ggagtatagt atatagtatc aacactccga gaaacaaagg aatgataagt atgatgatta 1636501 tagtttcatc aattattgct gtgttaatgg ctgtagctgt gatggtggtc agaataaagt 1636561 cctctgacaa gcctgtttca ccaaaaaaaa tcattcttcc gccgattttt atgagtacgg 1636621 gagcgttaat gtttttattt ccggtatttt gggtaactgg agcagagttt ttggaagcat 1636681 tcactttagg tgtgattttc tctatttttc taatcaaaac ttctaagttc gaaattaaaa 1636741 ataatgaaat ttacatgaaa cgctctaaag catttgtttt tatattagtc ggtcttttgg 1636801 tgatcagaat cgtgatgaaa tcgatcttga gcacatcaat tgattatggt gcactgagcg 1636861 gaatgttttg gattctggct ttcggtatga ttgtgccttg gagaatcgcc atgtatttat 1636921 catatcgaaa acttcataac gagctgcagt catctaatat tcaaatgaat taaaaaacct 1636981 ttcctcttgt caggaaaggt tttttatttg agaagggtct gataaggttc caaatcgatt 1637041 tttttgtccc gcagatgcct ttttaagaag gtatggtctc ttttaggagt tgcgagaata 1637101 tagcctttga tcataagttg ctgatcaatc tttgctacct tttcttttaa tgcaagctca 1637161 ccgattttgc ctgcgatttt agcttttgct gcatctctga acagctctgg cacgggcgca 1637221 gtcaattcat ctagaaactg tttgttttca tcgttccata aatgtctgct gttttcaata 1637281 tagtaatcct gccaatcaag ctctgatctg ccgtcctctt ttggtaaacg ctttaaaaac 1637341 tttcgaaaca tgaaaaaacc gccgattgat aataagacta ccatcatgat tacccaaaac 1637401 agaataaacc ataaaaacca tccttccagc atcaatcatt cccccttatt ctaaccatat 1637461 tgtatacgaa gagagattag aagaacacag taaaaaaaga atagaaaaaa gtgatagacg 1637521 tctagtcaaa agagatagta gatcatattc tattgtatag tgaatctgct atttggccat 1637581 gggagagtca ctagagggta tttgacgata aatggacgga aaaaaagtca ctttcataat 1637641 aggggatgaa agtgactttt tatgtttagc tgagaggaaa ttgaagagaa aaagaagagc 1637701 catcttctgt ttctttattg acggcgactg tgagtatttg attttcgcat tcgacttgaa 1637761 tgtttttgtc attaaaataa aaaggaagca tcatttgttt ttcaaaagtc tgtcctgacg 1637821 atttgacagt taagatgaac tcgcatccag aaagggtaac tgttacttgt gtaggctgta 1637881 aaaaagtcag atccgcttct ataatatact gctgacttgt ttcatataaa tcaataggca 1637941 atgtttcgtc gtaccaggcg aaggggtctt caaaaaattg ccgaagccat tcatccatac 1638001 tatcgaaatc attcgcatcg ttgcgttttg aatggttcat ggaagcattc ctccacatat 1638061 caaccttgct ttacatcata tgcggtggat tataaatggg tgaacgcata aaaaaacaga 1638121 cactaaggtc tgcttttctt acatatcatg gcttgagttg tgcttttgtc ttgtatggtt 1638181 tcggtttttt acttttttgc ttccgcttag aggctcgggt tggccgggat tgtgtccttt 1638241 aggggcgttt ttatgcatat ctttacttgt attcttattg gtcataaaat gagaacctcc 1638301 ttaaaagagt tcggtgttat tgattggttt ttcttttttt gttattttgg cgttctgctt 1638361 cagtcagtac aagctggtcg ttttcaatat agccggcgcc tttgccttgg ctttttgcgt 1638421 cattcattcc gttaatgacg tgattcgctt ttcttttgac catcattatc acctcaatca 1638481 taatatggct tcttttattg tgttatatga gagagcgtaa acagtaaaaa ttaccggtac 1638541 atttttctca taagtcgaac ttattgtatt taataaaaac attgatattt acttatgtat 1638601 gattttgttt taatatgaaa ttgtgagaaa attgtgatgg aatgtaatgt tcatctgaga 1638661 atgatctgat ctgaaggggg attttggaga atggcaaacg agcaaaaaac tgcagcaaaa 1638721 gacgttttcc aagcgagaaa aacgtttact acaaatggga aaacatatca ttactactct 1638781 ttaaaagcgt tagaagattc aggtatagga aaggtttcga agcttcctta ttccatcaaa 1638841 gttcttttag aatcagtatt gcgtcaagtt gacggcttcg ttatcaaaaa agaacacgtg 1638901 gaaaatttgg caaaatgggg aactgccgaa ttaaaggata tcgacgttcc gttcaaaccg 1638961 tctcgtgtta ttttacaaga cttcacaggg gttccggcag tagtagatct ggcttcactg 1639021 cgtaaagcaa tggcagctgt cggcggagat cctgataaaa tcaaccctga aattcctgtt 1639081 gatctcgtta tcgatcactc tgtacaggta gataaagcgg gtacagaaga tgcattagca 1639141 gtaaatatgg acttggaatt cgaaagaaat gcagagcgct acaaattttt aagctgggca 1639201 aagaaagcgt ttaacaatta tcaggcagta ccgcctgcaa caggtattgt gcaccaggtc 1639261 aaccttgagt tcttggcaag tgttgtccat gccattgaag aagacggcga gcttgtaacg 1639321 tatcctgata cgcttgtcgg aacagactca cacacaacaa tgattaacgg tatcggtgtt 1639381 ctcggctggg gtgtcggtgg aattgaagct gaagcgggaa tgcttggaca gccttcttac 1639441 ttcccagttc cagaggtaat cggcgcgaaa cttgtcggca agcttccaaa cggaacaaca 1639501 gctactgact tggcgttaaa agtaacacaa gtgctgcgtg aaaaaggcgt tgtcggtaaa 1639561 tttgttgaat tcttcggacc gggaattgct gaactgccgc ttgcagatcg cgcaacaatt 1639621 gcgaatatgg ctccggaata cggtgctaca tgcggattct tcccagtaga tgaagaagcg 1639681 cttaactacc tgcgcctgac tggccgtgat cctgaacata ttgatgttgt tgaagcatac 1639741 tgcagaagca atggcttgtt ctacactcca gatgcggaag accctcaatt tactgatgtg 1639801 gttgaaattg acctgtctca aattgaagca aacttatcgg gtccaaagcg tcctcaggat 1639861 ttgatcccgc tatctgctat gcaggaaacg tttaaaaagc aattagtcag ccctgcaggt 1639921 aaccaaggat tcggtttaaa tgctgaggaa gaaaataaag aaattaagtt taaactcctt 1639981 aacggcgaag aaacagttat gaaaacgggt gcgatcgcca ttgctgcgat tacaagctgt 1640041 acaaatacat caaacccata cgtgctgatc ggcgccggac tggtagcgaa aaaagcggtt 1640101 gagttagggc ttaaggtgcc taattacgtg aaaacgtcac ttgcaccggg ttctaaagtt 1640161 gttacaggat atcttgtgaa ttcaggcctt cttccataca tgaaagagct tggctttaac 1640221 ctcgttgggt acggctgtac aacatgtatc gggaactcag gtccgctttc accggaaatc 1640281 gaagaagcgg ttgcgaaaaa tgatcttctg attacgtctg tcctttccgg aaaccgtaac 1640341 tttgaaggac gtattcaccc gcttgttaaa ggcaactatc ttgcttcacc gccgcttgtt 1640401 gtggcatatg cgctggctgg aacggtaaac attaacttaa aaaccgatcc aatcggtgtg 1640461 ggcaaggatg gtcaaaacgt atactttaat gatatttggc cgtcaatgga cgaaatcaat 1640521 gcacttgtta agcaaactgt tacgccagag ctattccgca aagagtatga aacagtattt 1640581 gatgacaaca agcgctggaa cgaaattgaa acaacagatg aagctttata taaatgggat 1640641 aacgattcaa cttacatcca aaacccacca ttctttgaag agatgtctgt tgagccaggc 1640701 aaggttgagc cattaaaagg actgcgtgtt gtcggtaaat tcggcgattc agtcacaact 1640761 gaccatattt ctcctgcggg ggcaatcgga aaagatacgc ctgccggaaa gtatttgcaa 1640821 gaaaaaggtg tttcacctcg tgactttaac tcctacggct cccgccgtgg aaaccatgaa 1640881 gtcatgatga gaggaacatt tgccaacatt cgcatcaaaa accaaatcgc accgggtaca 1640941 gaaggcggat ttacgacgta ctggccgact ggtgaagtaa catccatcta tgatgcatgc 1641001 atgaaataca aagaagataa aaccggtctt gtcgtattag caggaaaaga ctatggtatg 1641061 ggatcttcac gtgactgggc tgcaaaagga acaaaccttc tcggcatcag aacggtcatt 1641121 gcagagagct tcgaaagaat tcacagaagc aatcttgtat tcatgggtgt gctgccgctt 1641181 cagtttaaac aaggtgaaaa tgcggataca ctcggcttaa cgggtaaaga agtcatcgag 1641241 gtagatgttg atgaaacagt tcgtcctcgt gaccttgtga ctgtaagagc aatcaatgaa 1641301 gacggcaatg taacaacttt tgaagcagtc gtccgctttg atagtgaagt tgaaattgat 1641361 tactaccgcc atggcggcat ccttcaaatg gtgcttcgtg aaaaaatgaa gcagtcctga 1641421 tgaatcaata ggaagagaag gcatttcgct ttctcttctt tttatgacac aatgtgctgc 1641481 ggaggtggca tatgctgaaa aaatggctcg cagggatcct gcttatcatg ctagtcggtt 1641541 atacgggatg gaatttatat caaacataca gcaaaaaaga agtcggaatt caagaggggc 1641601 aacaagcacc tgatttttct ttgaaaacgc tatcaggaga gaaaagctct ttacaggatg 1641661 caaaaggcaa aaaagtgctg ctcaattttt gggcaacttg gtgtaagccg tgccgtcagg 1641721 aaatgcctgc gatggaaaag ctgcaaaaag agtacgccga caaacttgcg gttgttgcgg 1641781 taaatttcac ttcagctgag aaaagtgaga aacaggtccg agcgtttgct gatacttatg 1641841 acttaacgtt ccccattctg attgataaaa aagggatcaa tgctgactat aacgtgatgt 1641901 catatccaac gacatatatc ttagatgaaa aaggtgttat ccaagacata catgttggca 1641961 ccatgacaaa aaaagaaatg gaacaaaaac tggatcttga ttagattcag ttttttttat 1642021 actcaaatat gcttacaagt tttcagaatt ggaaaaaata aaagaatatg cggaggtgag 1642081 aagcgtgaag aagatgagaa aacgttcttt tcatgagctc gtcatggaaa acaaaaaaga 1642141 gctgatgacc aatacagagt atttaaatca gcttgaggaa aagcttgaac agcgatttaa 1642201 gcaaaaataa cctttaattt gtattcatgt ttacccctcc ttttgagaaa cctatctgtt 1642261 gaggagggat aaacatggga aacaacaaga aaaacggtca gcctcaatat gctccaagcc 1642321 acttgggtac aaagcctgta aaatataaag ccaataaagg ggaaaaaatg catgatactt 1642381 caggacagcg gccgattatc atgcagacaa aaggcgagta gcgaaaattc gagtttattt 1642441 ctaggaggta catccgaatg acaaagaacc aaaatcaata tcagcagcct aatcctgatg 1642501 atcgttctga caatgtggaa aaattgcagg atatggttca aaatacaatt gaaaatatag 1642561 aagaagcaga agcatcaatg gagtttgctt caggagaaga taaacagcgt atcaaagaaa 1642621 aaaatgcaag gcgcgaacag agcattgaag cgtttcgtaa tgaaatacag gacgaatctg 1642681 cagcgagaca aaacggatac cgttcttaaa aaaccaggga aacctggttt ttttctttct 1642741 gatttgatta tggtaaaatg gggctaaatt gacgttaagg gagcagagta atcttgcatg 1642801 tatcaaaaaa agaaatagaa gtgcgttatg cagaaacaga tcaaatgggg attgtctatc 1642861 acgcaaatta tcttgtgtgg atggaggtcg gcagaacggc cttgattaag gacttaggct 1642921 ttttatatag tgatatggaa aaaaaaggcg ttctgtcccc agtcgttgat atcaatattt 1642981 cctataaaaa gccgcttcat tacggagaaa ccgcggttgt acatacatgg atagaggact 1643041 ataacggatt taaaaccgtc tatggttacc acatttataa tccggccggt gagctttcca 1643101 tcaaagccac ctcatctcat atttgtgtgg ataaagaaag ctttaagcca attcaattcc 1643161 gcaaagcttt tcctgattgg cacacagcat atgaaaaggc caaaaaatag ggaagtgaac 1643221 gggatatggc gtttggtgtg aaacgggagg aacttaaccg gtggaaacaa gcagtgaaaa 1643281 gaggagaaat cgcattttta acacattact ggctggatga ccgatttcca gaagcaaaga 1643341 ccgtgacaaa agccggctgt gcagacattg ataagctggt tcagtgggga gcggcgtacg 1643401 ggttaaaaaa agaatggatc cataagaaaa gtgaatttcc ccactttgat ctgctggggg 1643461 aaacacaaaa atatattttg gaacaagaaa acctaaccga tcatcttata cgatttcatt 1643521 tgtaaaaaaa gaacgcacat gaagtgcgtt cttttttatt ggtattcaaa aaccggttca 1643581 tcagcgtctt ctgaatagct gacgagaagg tcgtggttat caaagtacca taaatcactt 1643641 tcttcaataa agaaggtaat gccatcagct tctgcagtga ctccagcctc ttgtggggca 1643701 tctttcgcta caccgagaga aaaacccttt tgaacgttgc tgcagcctcc atagcggacg 1643761 aaaaagcgaa cctggtctcc gctttccaaa tcgagttctt ctttatacca gttcaatgcg 1643821 tcttcgttaa ttgtcatatt cataacagaa cacccctttg ttcttcattt gaattttctc 1643881 tattataaac gtattaggct attctgtgtc aaaagagaag ttttttaagc ttataaccat 1643941 tttactttag gttctgtttt attgataatt cgtttaatgt tcgctcggtg tctgtatatc 1644001 acaaaaatag tgagcagggt aacgacaatc aataaatacg tatcatggac aaagaaacta 1644061 tatataacag tatagatccc tgttaacatc gatgagagag aaacaaattt agtcaagtat 1644121 aaaaagatga agaataccgc aaccatcgtg ataaataaca ggggtgcgta aaatagcaaa 1644181 acgcctcctg atgtcgccac ggctttaccg cctttaaatt tggcgaagat gggaaacacg 1644241 tggcctaaaa ccgcaaagac tcctgcaaga agcgggtgaa tatcaacatg catgagaaaa 1644301 ggcaatgcag ttgccagtgt ccctttcaaa atatctccgg ctatgacgac cgaaccagct 1644361 tttacaccca atgtacggaa tgcattggta gcgcctaagt tgccgcttcc gtgctcccga 1644421 atatcaattc ctttggcaag cttgcccaca attaagccag atggaatgct gcctatcaag 1644481 taggccaaaa taatcaataa agcaattaac atctacattt ctcctttttc aaattccctt 1644541 ctttttattt taacatgaga tgtcatgatc tgatgataag tttttttgta aagtttgctt 1644601 acaaatcaaa tcaaacatgc atcatatttt gatttctcct gttttgatcg tgtaaaataa 1644661 gtgaaaaagg agtgacacac gatgcaaaac ccttctaaag cggaaattaa agagattctt 1644721 caaagaagca aacgtatagc ggtagtaggg ctttcagacc gtccggatag aacgtcacat 1644781 atggtttcaa aagcaatgca ggacgcgggt tatgaaatta tccctgtgaa ccctacaatt 1644841 gatgaggcgc taggtgtcaa agccgtttca tctttaaaag agatagacgg tccgattgac 1644901 atcgtaaatg tattccggcg ctcagaacag cttcctggag tggcggaaga gtttttagag 1644961 acagatgcgc cagtattttg ggcacagcaa gggctagtta atgaggaagc ataccagatg 1645021 ctaaaagaaa aaggcagaac ggttatcatg gatctgtgca taaaagtggc acacgctgta 1645081 acaaaatagg tgcagaactg caaaaatcct tgtaaattca aggatttttg ctttttaatt 1645141 ttaagatatt gtttgcgtat tacggtgaaa cagatacaat aaagcttgaa cagctttttt 1645201 tgaatacctt gtccagctgg gtttcggccg ttcgatttgc gaaggtctgc tgctttatat 1645261 ataataaaca aacatacgtt ctcatagtgt aaaaacagca ctagccgatg ttttgagaag 1645321 aactgattcg ttagctctat gttgcgattg caaacatatt ggttataatg aggagtccaa 1645381 ggcagtactg gctcgaggcg aggtttataa aaaatatctt atatacaaat gatgtgtaac 1645441 actgaaaaga gaaagacaat gttagttttt gaaaggggtt tgtacgtttg gctagaaaac 1645501 agcaatttga ttacaacgaa gatgccatac aggtgctcga aggccttgag gctgtcagga 1645561 aaaggccggg tatgtatatt ggctctactg acgcgcgggg tttgcaccac ttggtttatg 1645621 aaattgtaga taactctgtc gacgaggtgc ttgccggcca tggagatcac ataatcgtca 1645681 aaatacataa agacaatagt atttctgtac aggatagagg ccgcggcatg ccgaccggaa 1645741 tgcataagct cggcaaacca acccctgaag tgattttaac ggtgcttcat gccggaggga 1645801 aattcggcca aggcggctat aagacaagcg gcgggctcca cggagttggt gcatcagtcg 1645861 tgaatgcttt atctgaatgg ctgacggtta ccattgagcg ggacggtttt gtctatcagc 1645921 agcgatttga aaatggagga aaaccggtta catctctcga aaagatcggc aaaacaaaaa 1645981 agacgggaac tcttacacac tttaagccag atccaacgat gttcagcaca accacttata 1646041 attttgaaac gctctctgag cgcttaagag agtctgcgtt tttgttaaaa ggactgaaaa 1646101 ttgagctgat tgatgaacgc aatgaccagc gtgaggtctt ttattatgaa aacggcatag 1646161 aagcgtttgt tgcttactta aatgaagaaa aagacgtctt gtctgaagtg gtctcgtttg 1646221 agggtgagca tcattctata gaagtggact ttgcgttcca gtttaacgat ggttattctg 1646281 aaaatatttt gtcgtttgtc aacaatgtca gaacaaaaga cggcgggacg catgagtcag 1646341 gtgcaaaaac tgcgatgacg cgtgctttta atgaatatgc gcgaaaagtg gctttgctga 1646401 aagaaaagga taagaacctt gaaggcaccg atataaggga agggctttca gccattattt 1646461 ctgtccgcat tcctgaggag cttcttcaat ttgagggaca aacaaaagga aagctcggta 1646521 ccagtgaagc aagatcagcg gtggatgcga ttgtttcaga gcagcttgct tactttttag 1646581 aggaaaatcg ggacaccgca acgcttcttg tcaaaaaagc aatcaaggcg agccaggcgc 1646641 gcgaagcggc acgcaaagcc cgtgaagaag caagaagcgg caaaaaacga aaaaaatcag 1646701 aagcgacttt aagcggaaag ctgacgcctg cgggttcaag aaacccggca aaaaatgaat 1646761 tgtatctcgt tgagggagat tcagcaggcg ggtcagccaa gcagggacga gaccgcagat 1646821 tccaggcggt tctgccttta cgcggtaaag tcattaatac agaaaaagct aagcttgctg 1646881 atatctttaa aaatgaagag atcaatacga tcattcatgc gatcggcggg ggagtcgggg 1646941 cagatttctc aatcgatgac atcaactacg acaaaatcat cattatgacc gatgccgata 1647001 ctgacggcgc ccatattcaa gtgctgcttc ttaccttttt ctatcgctat atgaaaccgc 1647061 tcattgagca tggcaaggtg ttcattgcgc tgccaccttt atataaggtc agtaaaggaa 1647121 gcgggaaaaa ggaaatcatt gaatatgcat ggtctgatga agagatgggg gatgtcctga 1647181 aaaaagtcgg caaaggctat accattcaac gatataaggg tcttggagag atgaacgcag 1647241 accagctgtg ggaaacgacg atgaatccgg agtcccgcac acttgttagg gtcaaaattg 1647301 acgatgcggc acgtgtagag agacgtgtga cgacgttaat gggagacaaa gtagagccgc 1647361 gcagaaagtg gattgagaaa aacgtcgctt tcggcttaga tgaagaaagc aatattttag 1647421 aaaatgaaaa cttatcggtc gctgaggagg tttaatgatt gtcacagcca gaattatttc 1647481 atgatttacc attagaagag gtgatcggcg accgttttgg acgctacagt aaatatatta 1647541 ttcaagacag ggcgctgccc gatgcgagag acggattaaa gccggtacag cgcagaattc 1647601 tgtatgcaat gcatacagat ggaaacacgt ttgataaaaa cttcagaaaa gcggccaaaa 1647661 cggtcggtaa cgtcatcggt aactatcatc cgcacggtga cagctcggtt tatgaagcaa 1647721 tggtgcggat gagccaggat tggaaagttc gtaatgtgtt aatcgaaatg catggaaaca 1647781 atggaagcat cgacggagat cccccggcag ccatgcgtta tacagaggca cgattatctc 1647841 cgatagcatc tgagcttctt cgggatattg acaaaaacac ggttgaattt gtgccgaact 1647901 tcgatgatac aagcaaggag cctgtcgtac tcccggcgat gtttcctaac ctattggtca 1647961 acggatctac cgggatttca gcaggatacg cgaccgacat tccccctcat catctgggag 1648021 aagtcattga tgctgtcatt aagcgtattc aaatgccttc ttgctctgtt gacgaactca 1648081 tggaagttat taaagggcct gattttccga caggcggtat tattcagggc gttgacggga 1648141 taagaaaagc ttacgaaacc ggaaaaggaa aaatcattat ccgcggaaag gctgaaattg 1648201 aaacaatcag aggcggacga gaacaaattg tcattactga aattccattt gaagtaaata 1648261 aagcaaacct tgtaaaaaaa atggacgagt tccgtattga taaaaaggtt gaaggcatct 1648321 cagaggttcg tgatgaaacg gatcgaacag ggctgagagt ggtcattgaa ctgaaaaaag 1648381 aagctgatgc caaaggcatt ttgaatttct tatataaaaa tactgatttg cagatcacat 1648441 ataacttcaa tatggtggct atccataacc gccgtccgat gctgatgagc ctgccgtcta 1648501 ttttggatgc atatatcgga caccaaaagg aagttgtcac aaaccggtcc gtttacgagc 1648561 ttcaaaaagc aaaagacaga catcatatcg tagaagggct catgaaagct ttgtctattt 1648621 tggatgaagt gattgcaaca atccgttctt ctagcgataa acgtgacgct aaaaacaatt 1648681 tgatcgcgaa atatgaattt acagagcctc aggctgaagc catcgtgtca ttgcagctat 1648741 atcgtttaac caataccgat atcacagcgc ttaaggaaga ggcagaagag ctcggtaaaa 1648801 aaattgaaga gctcgaatct attctgagca atgataaaaa actgctaaaa gtgattacaa 1648861 acagcttaaa agcactgaaa aagaaatatg cagatacgag acgctccgtg attgaagaaa 1648921 aaattgaaga aattaaaatc aatctcgaag tcatggttgc atctgaggat gtatatgtaa 1648981 ccgttacgaa ggatggttac ctaaaacgga cgagccagcg ctcatttgcc gcttccaacg 1649041 gtcaggactt cggaatgaaa gatacggaca ggatgctgca tcagtttgaa atgaatacga 1649101 cagacgtgct gctgctcttt acgaacaaag gaagctacat ctattgtcct gttcaccagc 1649161 tgcctgatat cagatggaag gacatgggcc agcatttttc aaatctaatc actattgacc 1649221 gtgatgaaac gattgtaaag gctataccga taaaagaatt tgatccgtcg gcatatcttc 1649281 tattctttac gaaaaacggt atggtgaaaa agacagagct cactcattat aaagcacagc 1649341 gttattctaa ggcacttgta gccttaaatc tgaagggtga agatgaactg attgatgtac 1649401 atgtaacaaa tggggaaagc cagatcttta tggccactca cttagggtat ggtctatggt 1649461 ttggagaaga cgaagtgaat gtagttggcg cgcgtgcggc aggtgtcaaa gggattaact 1649521 taaaagagga tgactttgtt gtctccggtg agattcttca gcaatctgat tcaattgtct 1649581 tgttcacaca gcggggagcg gttaaacgca tgagtctttc tgagttcgag aagacatccc 1649641 gtgcaaaacg cggtgtcgta atgctaaggg aactgaaaaa gaatcctcac cgtgttgtag 1649701 cactgttcgc ttgcggtctt gaacagcgac taatggcaga aacagaaaaa ggcgacagaa 1649761 aagaactgca gacaaaagag ttgcggacaa acgacagata cagcaatggc tctttctttt 1649821 ttgatgaaga ggaatcaggc aaggttacag ctgtttggcg ccttcataca gaacaataat 1649881 aaaaaacccg ctcatactat atgagcgggt ttcgtttgtt ttttatcagc tttcatggtt 1649941 ggtgaataga tctgttacag catgaatgac ttcaatcccc tgccatacaa ataaattcag 1650001 cgctgtgaaa gaaaataagc ctaaaatcac cattcttaag ataaacaaca tgtttaacag 1650061 cctcctcata ttttcgttac ataatcgggt gatgttgaac atgaagtttg ccgaaataag 1650121 acgattgata aaatttggcc agtataaagc tttttttccg ctgacgtctg cgggagtatc 1650181 ccgtactttt gctttcagcg gtcagcagca gaacagccat tgcccataaa gcggtcagcg 1650241 taaatgcccc tgtgatggat ttcttctcat catcagcatt ttggccggct ttcatctcat 1650301 gcatttcctg ctggtcggct acggctttat aatgatggcc gatatcaaag gcgtggggaa 1650361 ttgagaacaa atgaaaactg gcaatcgcca agaataagat ggatgctttc aatatcgtta 1650421 cttttttcaa atgatctccc cctcctttaa tattactgaa tatttttata ataatacccc 1650481 aatccatcct aaaagtaaac ctgatttatt aaatttaaaa ataaatttaa ctttgttaag 1650541 tatatatctt tttgcttatt tttgaaagag aaaacttctt ttattagcgt atgtataccc 1650601 ggtttatggt gtgaataaaa acatatttta aatgatatgt tgtttaggat ttattacttt 1650661 atttatgtgt aaatcaaaga gaaaggcaag agaatgggaa gaaatgatta cattgttaat 1650721 agggtactct ttttttaaag ccagtttgca aggaatgttt ttattcgtag gaaaataata 1650781 gagaaggggt cgacagagta acatctggct atgacaatat tcttctcgaa aaaacttcct 1650841 aattcgtcat attgtgatat aataaaactc gttatgttaa aaaatctaac atcaaaatcg 1650901 aattcgtatt gaattgatga aaacgggagg taaatatgga gtcttttttc aatagtttga 1650961 ttaatattcc aagtgatttc atctggaaat acctatttta tattttaata gggcttggat 1651021 tattttttac catacgtttt ggttttatcc aattccgtta ttttattgaa atgttcagaa 1651081 tagtagggga gaagccggaa ggaaataaag gtgtttcatc tatgcaggca ttctttattt 1651141 cggccgcatc ccgagtcggc acagggaatt tgactggtgt agccttagca attgcgacag 1651201 gcggaccagg cgctgtattt tggatgtggg tagtggctgc agtaggcatg gcttcaagct 1651261 ttgtcgaaag tacattagca cagctttata aggtaagaga cggggaggat ttccgcggag 1651321 ggccggccta ctatattcaa aagggtcttg gtgccagatg gcttggcatc gtttttgcaa 1651381 tcttaattac cgtctcattc ggcttgattt ttaacgctgt tcaaacaaat acaattgctg 1651441 gagcattgga tggcgcattc catgtaaata aaatagttgt agccatagtt ctggcggttt 1651501 taactgcgtt tatcattttc ggcggtttaa aacgtgttgt cgctgtttca cagctaattg 1651561 tgccggttat ggcaggcatt tatattctta tcgctttatt tgttgtcatc acgaatatta 1651621 cggctttccc tggcgttatc gctacaattg ttaaaaatgc tttaggtttt gaacaagtcg 1651681 tcggcggcgg aataggcggc atcatcgtta tcggtgcgca acgcggactt ttttcaaacg 1651741 aagcaggaat ggggagcgca ccaaacgcgg ctgcgacggc tcatgtatcc catccggcaa 1651801 agcaaggctt tattcaaaca ttaggcgtat ttttcgatac atttatcata tgtacgtcca 1651861 cagcatttat tattttgctg tacagtgtaa cgccaaaagg cgacggcatc caagtcacac 1651921 aggctgctct taaccatcac attggaggct gggcgccgac tttcatcgca gtcgcaatgt 1651981 tcttgtttgc attcagttca gttgtcggca actattatta tggcgagaca aacattgaat 1652041 ttattaaaac aagcaaaaca tggctgaaca tttaccgtat cgctgttatt gctatggttg 1652101 tgtatggatc tttatcaggc ttccaaatcg tttgggatat ggcggacctc tttatgggta 1652161 tcatggcgct gatcaactta attgtgattg cgctgctgtc aaacgttgct tacaaagtgt 1652221 ataaagatta cgcgaaacag cgtaagcaag gacttgatcc tgtgtttaaa gcgaaaaaca 1652281 tcccagggct gaaaaacgct gaaacatggg aagatgagaa acaagaagca taatataaat 1652341 ataaaacaaa gctgcattca atagttgaat gcagcttttt cattattgga aataaattta 1652401 atttttcgac tcgaatgaaa aatgacgtgt aaagtcccaa ttcagtccag ttttctttgt 1652461 tctatatgtg tcatgtgtgt cttattcatt ggaggtagag caaattgaca ggcttttaaa 1652521 cctccccaaa acaagaaatt aggttgatag acaatcatga gaaagatttt tacaatgagt 1652581 tcgtgctcat aagaagtgta gagccaaaat gatgcgaagg aggaaaagat cagatatgaa 1652641 acggtcaatc tctattttta ttacgtgttt attgattacg ttattgacaa tgggcggcat 1652701 gatagcttcg ccggcatcag cagcagggac aaaaacgcca gtagccaaga atggccagct 1652761 tagcataaaa ggtacacagc tcgttaaccg agacggtaaa gcggtacagc tgaaggggat 1652821 cagttcacac ggattgcaat ggtatggaga atatgtcaat aaagacagct taaaatggct 1652881 gagagatgat tggggtatca ccgttttccg tgcagcgatg tatacggcag atggcggtta 1652941 tattgacaac ccgtccgtga aaaataaagt aaaagaagcg gttgaagcgg caaaagagct 1653001 tgggatatat gtcatcattg actggcatat cttaaatgac ggtaatccaa accaaaataa 1653061 agagaaggca aaagaattct tcaaggaaat gtcaagcctt tacggaaaca cgccaaacgt 1653121 catttatgaa attgcaaacg aaccaaacgg tgatgtgaac tggaagcgtg atattaaacc 1653181 atatgcggaa gaagtgattt cagttatccg caaaaatgat ccagacaaca tcatcattgt 1653241 cggaaccggt acatggagcc aggatgtgaa tgatgctgcc gatgaccagc taaaagatgc 1653301 aaacgttatg tacgcacttc atttttatgc cggcacacac ggccaatttt tacgggataa 1653361 agcaaactat gcactcagca aaggagcacc tatttttgtg acagagtggg gaacaagcga 1653421 cgcgtctggc aatggcggtg tattccttga tcaatcgagg gaatggctga aatatctcga 1653481 cagcaagacc attagctggg tgaactggaa tctttctgat aagcaggaat catcctcagc 1653541 tttaaagccg ggggcatcta aaacaggcgg ctggcggttg tcagatttat ctgcttcagg 1653601 aacattcgtt agagaaaaca ttctcggcac caaagattcg acgaaggaca ttcctgaaac 1653661 gccatcaaaa gataaaccca cacaggaaaa tggtatttct gtacagtaca gagcagggga 1653721 tgggagtatg aacagcaacc aaatccgtcc gcagcttcaa ataaaaaata acggcaatac 1653781 cacggttgat ttaaaagatg tcactgcccg ttactggtat aaagcgaaaa acaaaggcca 1653841 aaactttgac tgtgactacg cgcagattgg atgcggcaat gtgacacaca agtttgtgac 1653901 gttgcataaa ccaaagcaag gtgcagatac ctatctggaa cttggattta aaaacggaac 1653961 gttggcaccg ggagcaagca cagggaatat tcagctccgt cttcacaatg atgactggag 1654021 caattatgca caaagcggcg attattcctt tttcaaatca aatacgttta aaacaacgaa 1654081 aaaaatcaca ttatatgatc aaggaaaact gatttgggga acagaaccaa attagttaag 1654141 cttttttttg gcggacatca gtaacgatgt ccgtttttat catctaatag gaggtttgcg 1654201 ttgtggatga aatactgaaa cagtatatgg tgctgtataa aaaaatgagt aatatgataa 1654261 atggtcccga ctatccaggt aaggaaaaag acatccagca tcaaaaagat cagatcgaag 1654321 tttacgaaaa acagctgcag caaggatttt ctacagatta tgactatgat gtgtttgctg 1654381 attctgttat caaatgcgca tatggcgata tgacgctgga agatttagaa gccgtttatt 1654441 atggattgac aacaccattt ttttgatttg tcattcagca gtaaaatttc aatttctgtc 1654501 tcactaactt aagtatactt tgatattgag acagaaattt atttattttg tttacttcct 1654561 agaatatata ttatgtaaac tagaaaagat gaagaataaa gctttgctgt ttttatgtac 1654621 atcctttctt cttcctgtaa ttcagcaaca aaataaaaaa gcgatttccc aatcggaaaa 1654681 tcgccaattc agacactcta ttatttatgt gtgtctttgt gctcttaacg atttacaaca 1654741 aatgttgtca cgctttgagc tggaagatga gcccaaaaat gattgcctga tacagtgaga 1654801 ttcgttccag gttgtagatt gctgctgctg ctcgtgatcc atctagatac gtttgaagca 1654861 gatccattct gcaaaacaaa gttttggttg actcctgtgt tgcttttatt gatggcaaca 1654921 ataacgacct tgttgtcacc tttataggct gacacgtaaa cgttcgcatt agggtttttc 1654981 gttgcatcaa tccttacata gccgggacgc acaaactttg agaaatgagc catattgtag 1655041 ccgcgtttgc tgatcgtacc atcttctttc ataggtccat atgatcttcg gatgtaccac 1655101 catacataag cttgaaagtc cccctctacc atcgcattgt gaatatgctg tgaaacatcc 1655161 aatgcctcag gccatcgatc cgccgagttg gtatcactgt ttggatagta tacttccgtc 1655221 atccaaaggt ccttccccgc tcctttttgt ttgaaaagag gataagggaa ttggctgacc 1655281 tgggtgccgt acaggtgagt tccgagaata tccatattgg caagagcctg cggatcgttc 1655341 aagatcgggt ccgacaaatt cttcaagtat tgaaatgact caggcgcaat gacgcgggca 1655401 ttgatcgagc cggcgttttc tctcataaag cgaagtattt cttgcggcgt ccaccacgtc 1655461 cactcgtgag cgtaatcagg ctcgttttgg accgaaatcg cgtaaagatt cacaccatta 1655521 ttcttcatga aggtaacaaa atcgttaaga tgctgcgcgt atgctgcgta cttgttgtat 1655581 ttcagccgtt tagccgatgt gtcaccattc cgattaaagg tctcaaccat atcacttgga 1655641 ggattccaag gagaagcaaa aacgattgct ccgtgtttga ccgcactctt tgcagtctcc 1655701 acctctttat accaattatt tcgattttca tctacatgaa ttcttaagat tgaaaatcct 1655761 aactggttct gtccattgcc aaaagcagtt tctctttgag ctgctgtaag atccccagcc 1655821 caagccggat gattcatccc tccaaaaccg cgaatcactt gtttctctgc agatacatta 1655881 actgttacat cacttgctgc caaaacttca gtagcgcctg gccctaacat gactgacagc 1655941 atagtgaaac atactaatag tacacaaatt gtttttttta tgcgtggaat catttattcc 1656001 tctccttcgt catgtgtctt ttacggtatt aaaaaatctg catggcatat ccataatggc 1656061 gggctgttcc ggtgctggcc cgtacttcac ccgcctcgtt tttaagcggt cccattacga 1656121 gtactatctt tgcgtaaact gccagtaatc aaaattaaac aagtttcctg tacctgttcc 1656181 ggtaaataca aagaatactt tgtgcacacc ggttgccccg cttaccgcag tttctatttc 1656241 cctccacgtt tgcgctccgc ctgttgaagg cacattcaga gttccaacaa gcttaccgtc 1656301 tgcactgtcg aggcgcactt ctattttccc gcctaaagtg gatgctacat ttgctttaaa 1656361 tgacctggca ccgcccgctc cgaagtctgc atttcctaca gcaatccagt ctccattttg 1656421 aatgcttgtt acatgctgat tatttactgg cccgccgggt gctgtggact tctctgtcaa 1656481 aatgcgtcca ttccaagcaa acgtttcagc ttctacccgg ttatatgggt ttaaattgga 1656541 aatttgtgtt acacctgcat aatttgccgc tacctcttga atagatccat ctgcattatg 1656601 caccagctta ttaatatggg gagagcggta tcctttgccg gccccgaaca gagcggaact 1656661 gacagtttgc gcatggtaca ccacatacca ctcgttttta aaattgaaaa cagcatgatg 1656721 gttgtttccg ccacctccga aaaatgcacc cggatttttc aggaagtgcc ctctatatgt 1656781 aaagggaccc atgggacttg aactggtcat gtagccgatc tcacccgggg gtttatcggc 1656841 cgggtgcgtg ccgccgaaat tgatgcaata ggagtaataa tatgttccgt tatacttgtg 1656901 caatcccgaa tcttcaaaca tgaaaggcgc atcaattgta gatgcacttc caacaacact 1656961 cgtcatatca ggccccaatt ttatgactct agccgtttta ggattggccc attgtccctg 1657021 cgttggattt gaaacgccag gaacgcctcc gccggcatac aggtaaccgg ttccgtcgtc 1657081 atctacaaat actgccggat caaaaagcca tacaacacca gacattcctg gcgtacttgg 1657141 cgttacgagc ggttttccga ttgggtcggt ccatggacca atcgggctgt ctgcggtgag 1657201 aaccccgata cctccgccgc tgtttgcgaa ataaaggaag aatttatcct tgccattaat 1657261 ttttttaact gcgattgacg gtgcccatga cgcacctgcc cattttgcaa ttccacggcc 1657321 tccattagct ccattggcac ctgctaccgg aatggctccg tggtctgtcc agttcaccat 1657381 atccgctgaa gatatgacga atactctatt caaattggca aatgaattat ctttaattgt 1657441 tccgttgcta ttatattcat agtcatcact tgacatatag atgtagactc ttccgttata 1657501 ggtcagcgca accggatccg ctcccaaatg atggtcgata agcggatttg aattccctat 1657561 atgttttgca attgtagtac tagtggcagc atacgcagac ttcccagata agcagctcaa 1657621 taataaaact agaatccata aacatacgct acactttttc ctcatcactt cacatcctcc 1657681 tttttcctta aaatggggga ttttcttttg gaatttgata acaacaggtc acgaagattg 1657741 cacgcataaa gtagccggaa gctgtttagc aatgttccca gttgttctga aagctcatct 1657801 tcatgtgtct ccattctctc ttttcttcga ggagatcgca ccactccttc aaaattgttc 1657861 aaaaaaactt ccccattcct agcgaccatt gtccagaaaa taaaaagaca ggattgttca 1657921 tggcctccca ctaatcacat tgaacggaga ttacatcatt atccaagata tccctttatc 1657981 taacatccta catcattaaa aaaattgtgt atagaaactt ttggaggagt tagtgttcga 1658041 ttctacaaag gaactggata catttattca ttgataagat ggggctaaca ctccgtttat 1658101 atttgtatgt tttcagacac aaaaaacagc cgttcaatgc ggctgttttt ttcaagagta 1658161 taagactatt gagcggtata cccgcttttt catgttttgt tcatatttta ttaattgttt 1658221 attcaacact gtccgctata gtaatccata tcaacaaata tgactgccac tcgcatcttt 1658281 tatgaaggga ggttcgttac gctgaaagaa aaaataaaga cattaggccg tttttgcacc 1658341 gtaggcgtcg gcaatacgct gatagatttt ggtgtcttct ttcttcttac cgcttgtcat 1658401 gtctcttatc tgccggcgca gatctgctcc tatactgcag gtatcgtcaa cagctatgtg 1658461 tggaaccgga attggacgtt ttgtgtgaaa cgtaaggctg acgggaaaga gatcgtgcgt 1658521 tttctcatga ttaatattgc cgcgtcaggg atcacctttt tgctgcttta tttgtttcaa 1658581 aattgcggct gctcgctttt ggtgagtaag ctcgccgcca ctatcggcgg aatgatgatg 1658641 aattttatcg gaaaccgaat ctgggtattt ggagattcgc tgaaaaacat acaggatcag 1658701 gagtgaagat gaatgagaaa aaaagtgaga aaagcggtta tacccgcagc gggtttagga 1658761 acgagatttc tgccggcgac aaaggcgcag cctaaagaaa tgcttccaat cgtcgacaaa 1658821 ccagcaatcc aatatattgt agaagaggcc gcagagtcag gaattgaaga tatactgatt 1658881 attacaggga gaaacaaacg ctcgattgaa gatcattttg atcggtcggc ggaattggaa 1658941 ttcaatctcc gggaaaaagg caagacggag acacttaagg aaatgcagca gattgccgat 1659001 ttggccaaca ttcattacat ccgccagaaa gaaccgctcg gattaggcca tgcggtgctg 1659061 tgtgcggagc attttatcgg agatgagcct tttgctgttc tcttaggtga tgatattatg 1659121 gtgtctgaaa caccggctct tcggcaatta atggatgtat atgacgttta tggcacagag 1659181 gttgtcggtg tacagtcagt tctccctgag gatgtcagca aatatggtat tataaataca 1659241 tcagggtctc aagggcatgt atatgaagtg aacgatttag tggaaaagcc ttctcctgaa 1659301 gaagcacctt cggaaatcgc agtaatggga cgttatgtgc tgaattcttc gatcttctcc 1659361 gttttgaaga caattggcag aggcgcgggc aacgaaattc agctgacaga tgcgcttcgt 1659421 gaggtttgcc gtaaggagcc gatccatgcc cggctgctgg aaggaaatcg atatgacatt 1659481 ggcgataagc tgggctgttt taaagcgagc accgaaatcg gcttaatgcg tcccgaaatg 1659541 agatctcagc ttttggccta tttagaagat gtgatcaaac gggaaacgaa agaaatgctg 1659601 cggtaaaaaa attgtaacca tcttgctcgt caatcagtca tataatagtg aaaaagatta 1659661 ggacaggttg tgaagaatgt gggcagtttg ataagcgaaa ttttaacatg gctgacgaac 1659721 atgggatatg cgggtattgc gattgggtta atgattgaaa tcattccgag tgagattgta 1659781 ttagcttatg gcggctatat ggtatcggag ggcacgattg gatttattgg cgcaattatt 1659841 gcgggtgtta tcgggggcac cattgcccag atctttattt actggatcgg tcgctatggc 1659901 ggcaggccat ttctggacaa atacgggaag tatttattga ttaaaaagca tcatatcgat 1659961 atgtcggaaa actggtttca gaaatacggc gccggagttg tcttctcggc tcgttttata 1660021 ccggttgtca gacatgccat atccattccg gcaggtattg ccagaatgcc ttttctcaaa 1660081 tttgtggtac tgactgtgct tgctatcatt ccatggtcta tcctgtttgt ttatttaggc 1660141 atacagctag gaagccagtg ggatgatgtt gagaatatag caggcactta tacaacaccg 1660201 attatgatat tggctgttgt cgtgatagcc ctttattttg tgattaagaa acgtacagcc 1660261 atatttaaac gatagctagc ggatatgcat aggggtgact gacgctcccc tatgcatatt 1660321 tttttacttg cgatgttgat ttgccagctt cagattctcc gctaaaaatg cgacaaacac 1660381 ttcatcccgc acgagcgatg cggcataatt tctcttaata aaccattctg cctcttcaaa 1660441 cgctgcgaat gtttcgtctt gggtttctcc gttaatttga atattccatt cgttgtctaa 1660501 agggaaaaga aaaaatctca tttgtgcgcg attttcatat aatgatccat tcgcagatcc 1660561 ctttagatta tagatgttac ggaaggcatc cggccgtaca ggatcaatac ggaaagcttc 1660621 agctacaaac aactcgtata cttcatcggt tattgaacag ccggacgctt ttgcatgccc 1660681 tccgccgcca tatcggccgg cgatttctga cacatcgatg taatcatgaa tggtgcggag 1660741 actgactcgt tttgacccca tgctcaaaat cgcaatgtaa tcgaggtgcg ggttatcttt 1660801 ccctagcctg ttccccagct ctgaatggta cgattcagcg tgaacgatgc ctacacagtg 1660861 ttcgtgaaca aaggtttgta ccatttccct tttctttctg cggaggtagc gctcgatttt 1660921 ttcgtcttct aaatcaagca gtttttcttc aaaatcatcg aagaaaaatt cgtcatgcgt 1660981 ggaaaggcgc tggatcattt ttgcttcaaa ttcatcgatt gacagcaaaa agaaaagatc 1661041 attaagccgc ttcgcctgtt tttgatcgta ccgctcccac tcccatgtat cgtattggcg 1661101 gacgagctct gtgaattgat ctaaggcgtt tgtcggtttc atgaagccat tttcaatgag 1661161 atagccatat aaaagcgatg tcgcggatgt gagccttcca tcatcgtatt ccacctggac 1661221 aaatccccat tcatgctcat tcaaatgaag ggctgtttta tgatggtcaa tgagcttcac 1661281 tttgccccct gcatgaacat actcattcaa tctctcttcg ttttcttcat tgacggcgag 1661341 atcggtgatg aataacgcgt cctgtctgtt gctctccttc gctttttcta aaaagtactg 1661401 cacctgtgcg tttaagccgt tgacagagtt ataccggatc tctacgtctt ttccgaacgc 1661461 caattttgct acgattccgc atcctactcc gtccaagtcg ttatgtgaat ataaatgata 1661521 cataatgtag gccccttttt atgataaact gacaattgcc gctagaggtg cggcagcctt 1661581 tatttactat tctaaaaaac caagcgtttt atgcaatggt aattagttga cataatgttg 1661641 ttattgtaaa tatataaagg agcgcttttt ttgcgctcct aagttcttgc ttttacaccg 1661701 gataaaccgg atgctttcga ttggtaaatg tcatttcctt tgtcatgtat gccttgagcc 1661761 gtttggccag ctcatcacgc agcgaattgg ctgggataac agcatcaatg atcatttctg 1661821 aagccagacg gtagatattg atgtcctctt tgtattcctc ccgtttgctg ctgataaatg 1661881 cggctctctc ttcttctggc agctcggcga tttttttagc gtagacagcg tttacagcgg 1661941 cctcagggcc catgacggcg atttgggcgg ttgggagcgc tagacagcaa tccggttcaa 1662001 atgccggccc tgccattgca tacaaccccg ccccgtaagc ttttcggaca atgacagaga 1662061 gttttggaac agttgcctcc gacatcgcag aaatcatttt cgctccgtgt ctgataatcc 1662121 cagcctgttc tacttttgtg ccaatcataa aaccggggat atcggctaag aacagcaatg 1662181 ggatatgaaa agcgtcacat aaggtaataa acttagccgc tttgtctgct gaatcgtgga 1662241 ataagacgcc tccttttacc ttcggctggt ttgcaacaat gccgacaggc tgtccgtgga 1662301 ttcgtgcgag gcccgtcaat aattccggtg caaataaggc tttgatctca aaaaatgagt 1662361 cttcatctat gacccgctca atgagctcat gcatatcaaa aggtgcgttt tgattttgcg 1662421 gaatgacgtc ggcaagcgga gtttcgaagt gttttggcgg gcgtttctca tgaatgggcg 1662481 ctttttcttg aaaatttgcc ggaaagtaag acaaataagc ccgcaccagc tgtatggctt 1662541 cttcttcagt ttctgcaaga atatctccgc agccggagat tgagcaatgc atacgggcgc 1662601 cacccatttc ttcgagagac actttttctc caataaccat ttccgccatc cttggcgaac 1662661 ctaaatacat ggaggcgtta ccgtctacca taacgacgat atcacagaag gccggaatat 1662721 aagcgcctcc tgccgcagat ggtccgaaaa gcagacagat ttgcggaatg cgtcccgata 1662781 atttgacttg attgtaaaaa attcttcctg caccgcgtct ccctggaaag acattgattt 1662841 ggtcggtaat tcgggcgcct gccgaatcga ctaaataaat gagcggacag tttaattttt 1662901 cggcgatttc ttgaattctg atgatttttt caactgtttt tgctccccat gaccccgctt 1662961 tcactgttga atcattcgcc atgacgcaaa cggtttggcc gccgattttg ccgatagcgg 1663021 ttacaactcc gtcagcggga agcccgtctg acatacattc cgcaaaaaaa gcgtcttcta 1663081 gctcaatgtc atcgtcaaag agaagggaaa gccgctctct gacaaagagc ttgccttttt 1663141 cccgattgct ttgatgatac ttttccgctc cgccttttcg aatccgttca gcccgttctg 1663201 ttcgttcctt ttcataatcc atcagcattg cctccctttt atattccctt gtatacggcc 1663261 cgtctttttt cttgaaaggc ctgaagccct tctctcctgt cttttgtcgg gatggtttgt 1663321 tcatacgctt tttgttcaat cgcaaggcct gtagcaagat ctgtctccaa tcctttattg 1663381 attgcaaatt tagcctgacg gacagcgatc ggtccgttgg cagaaatggc tgcggccagt 1663441 tcctctgctt ttggcataag gtcacaagga gccgtgacat gctctacaag gccgatttct 1663501 tttgcttcgt gtgcggtcac gcgtctgcct gtataaatga attcttttgc ttttcctctg 1663561 ccaatcagcc ggggcagcct ttgggtccct ccagcgcccg ggataatagc taaccctgtt 1663621 tccggaagtc ccagcacagc tgcttcagtt gcgattcgaa ggtcgcatgc caatgccaat 1663681 tctagtccgc cgcctaatgc gcttccattt atcgcagcta tgaccggctg cggcaaggca 1663741 tcaagtaaag ccgccgttct ttgaatgaga gatacacttt ccagaacctg atcttctttc 1663801 agttttatcc gttccttcag gtctgcccct gcacaaaacg ctttttcacc ggtgcctgtg 1663861 aggatgacgc aacggatgtt tgagttaaat tcaatttcct ggataatcat ttgcaggttt 1663921 ctaagcattt ccgctgaaag agcatttgct gcctgaggcc tgtttaaggt gatcaacgcc 1663981 atatgttcat ttttaacagt aaaaagaata gaatctccca ttgtatgcgt cctccctttt 1664041 atcaagatga tttaaacacc tgtaaatttc tgctcggcag cggtttgccc attttttctt 1664101 caatccattt ggccgcagat agcagttttt ctagctttac atttgttttg atatccatct 1664161 gttcaagcat gtacacgata tcctcagttg cggcgtttcc tgatgaacct ggcgcatatg 1664221 ggcatccccc aagcccgcct gccgagccgt cgaacaccgt gatgcccatt tggagtgctg 1664281 tgaccatgtt ggccagagcg gttcctctcg tatcatgaaa atgcagggca atttgattag 1664341 ccgggaatcg tgccaaaaga gcttcaagta cagtttccac ttgggcggga ttagctgctc 1664401 caatcgtatc tccaagcgac agttcagaaa tcccaaattc aaatagagct tctgaaaggc 1664461 gaatgacttg ttcaatgggg acatcttttt cgtacggaca gccgaaaaca gtcgagaggt 1664521 aggctcttgt tgtgaggttt gctttttgtg cgtcgttgtt tacttgtttg agtatatgga 1664581 gggattcaga agtggattta ttgatgtttt ttctgttgtg cgtctcgctg gcggacataa 1664641 aaacgcaagc ctcgttaatg cctccttcaa gtgcattctc cagtcctctt tgattcggga 1664701 caagtgccgc gtacgttacc cctttttctc ggtcgatgcc ttttgctaca tcgatagcat 1664761 ctcgaagcgc cggaatccat ttcgggtgaa cgaaggatgt gatttcaata tacgacagcc 1664821 ctgtccggga aagctggttg atccaggtta ttttatcctc tgttgcgatc caaacgggct 1664881 cgttttgtaa gccatcacgc gggccgactt ctttgattgt cactttttta ggatatggca 1664941 tggtcttcct ccaaattatt gagtggaatt gctcagttcg agcagtacgt ctccttcatt 1665001 tacaaagtcg ccttcctttt ttttgacttc ttttacgatt ccgcttctat ctgcaacgat 1665061 cgggatttcc attttcatcg attccaaaat ggctacctcc tggccctttt cgatttggtc 1665121 gccggctttg acgtggactt tccacaggtt tcctgccatt tgtatgctaa ccgtcatgac 1665181 aactgcctcc tttataggtg ctgtttcaaa aagtcagtcg tgacatcccc ttctttaaat 1665241 gcctttgttg ccgcagcctg tatgaggagc ggaaggtttg ttttgattcc ctctacacga 1665301 tagtcgcgaa gcgctgtctc tagtttttca attgcttctg ttctggtttg gcctttgaca 1665361 atcatcttag cgatcatcgg gtcataaaaa ggggtaacgg tgctgtcttt tgctaccgca 1665421 cattcgtgtc tgactccttt ttggtcagga agtgaaaacg cagtgatcgt acctggtgac 1665481 gggaagaagg tcttgggatc ttccgcgtat attcgaacct ctatcgcatg cccgttccgt 1665541 tggatgtctt tttgggagaa tgtgagtgta tggcccgcag caatccgcag ctgctgctca 1665601 actaagtcca ggcctgttat ttcttcagtc acggggtgtt caacttgcag tctcgtattc 1665661 atttcgagga aataaaaatt ttgtttctgg tcaactataa attcgatggt gcctgcgttc 1665721 gtatagccga ttgccttcgc tgcttttacc gctgtttgac cgatcttcat tcttagttca 1665781 tcgtctacaa atggagacgg tgcttcttca atgacttttt ggtggcgcct ctgaacagag 1665841 caatcacgtt caaacagatg tactgtatgg ccgtgttgat cggccaaaag ctgaacctcg 1665901 atgtggcgcg catgttcaat aactttttct atatacatag acccgtcacc gaaaaaatct 1665961 gctgcgcgct ttttgtttcc ctcgtacgct ttttttaatg cttcttcatt ttcaacacgc 1666021 tgcattccga tgccgcctcc gcccgctgaa gctttcagca tgacaggata gccgatttga 1666081 cttgcggtgc ggcaggctgc ctctatatct ccgagggatt cagaaacgcc cggcaccaca 1666141 gggacacctg cagcctccat tgcttttcgc gcttcaattt tgctgcccat ctttgcgatg 1666201 atatcagggg aaggtccgat aaacacgatg ttttcttgct tgcagcgttc agcgaaccgg 1666261 ctgttttctg ataacaatcc atatcccggg tggatcgcgt cggcttttgc ttttttcgcc 1666321 gtctttatga ttctctctat atttaaataa ctttcactga ctctcgattc cccgatcaaa 1666381 tatgcctctg tagcggcttt tgtatggggc gcgtccttgt ctgcttctga ataaacagcg 1666441 accgttttaa tgccgagacg gctgcatgtt cggataattc tcattgcaat ttcaccgcgg 1666501 ttggcgatca gtacttttgt aaacatgatt tcacctcatt gacttgatga taagttgaac 1666561 atttcaatcg ttttttctcg cagtttatat ttttgaattt tgcctgaggc cgtcatcgga 1666621 tagtcatccg taaaaataac ataacgcgga attttgtggc gggcgatttt ccctttgcaa 1666681 taggctttaa gctcatcagg tgaaacgctt ttaccgtctt tcagtttaat ccaggctgca 1666741 gcttcctccc cgaatttggc gtcaggcaca ccaaccacct gtacatctaa aacagcggga 1666801 tgctggtata aaaattcttc aatttcccgc ggataaatgt tctcgccgcc tctgatgagc 1666861 atatctttta atcttccggt gatgcggcag tacccgtctt catccatgac agcaagatct 1666921 ccggtaaaca gccatccgtc atgattgatt gcttttctgg tcgcatcttt gtctttataa 1666981 tagcctttca tgacgtgata gccacgggtg cacagttctc cctgcatgcc tctttgaact 1667041 tcttgacatg tcccgggttc tacaattttc acctcagtat gtggcagggc acggccggtt 1667101 gtttcgactc ttcttatgaa ggaatcattt gctctcgttt gtgtaatgac tggcgaggct 1667161 tcggtttgtc cataggcgat cgtaatgtct ttcatgccca tcctttcaat cacagctttc 1667221 atcacttcac ttggacaggg agagccggcc atgattcctg ttcggagcgt cgatagatca 1667281 tatgcatcaa aatccggatg atgcagctcg gcgataaaca tggtaggcac accatggagc 1667341 actgtgcatt tctctttttc taccgtttta aggacggtaa cgggatcaaa ttcttgcacg 1667401 ggtatcatgg ctgccccgac ggatacacat gccaaaaccc caaggacgca tccaaagcag 1667461 tgaaaaaacg gaacagggat gcacatgcgg tcttgagagg ttaaagccat acattcagcg 1667521 atattagcag cgttattgat gacattgaaa tgggtcagca tcacgccttt tggaaaccct 1667581 gtcgttcctg atgtgtattg catattaatc acattgtctt tatccaggct gttcattctc 1667641 tcttcaagct cagcatctgt cactgttttc gccaatatct ctgtatcgtc ccaatgatac 1667701 atgccagaca atcgtttatt gccaatatag atcagcgttt ttaaaaaggg atagcgttca 1667761 gatttcagtt ggccgggctt tgcttcttgc agttctggaa ttaaactgtt cacgatgtct 1667821 ggataagaag tgcccctgta tgaatccatg ataataagcg ccgcggcatc cgattgcttt 1667881 aacaagtaat caagctcatg tgcttgataa ttggtattga cggtcacgag cacggctccg 1667941 atcttcgcag ttgcgaactg gacggcaagc cattcagaga tattagaagc ccatatggcg 1668001 acgtggtctc cttttccaat ccccatccgc atgagacctt tagcggtttg acggcacaga 1668061 ctgtcaaatt gagcgtacgt atagcggata tttcggtctg gatacacaac agcatctcga 1668121 tcgggatacg catcagctgt ttgttccagc agcctgccga ttgtggaatg gatgagttca 1668181 gccattcatt gttcctcctt tcttaatgat aggaaagcgt ttacattttt attttaaaag 1668241 ctgtctggcg atcacgagac gctgaatttc agatgtgcct tcaccgattt ccattaattt 1668301 tgcgtcccgc agcatccgtt ccaccccata ctctttcata tagcctgaac ctccatggat 1668361 ttgaatggct tgattgcaag ctcttgtcgc catttcagat gcgaatagct tggcgtacgc 1668421 cgcttctttg gtgaacgggc ggttatgatc tttcagccag gcggctttta acaccatttg 1668481 ccgtgccaga tcaatttcca tcgccatgtc agcaagctta aattgaatcg cttgaaagga 1668541 agaaatcggc tgtccaaact gctttcgctc tttcgcatat gccaatgatg cgtcaagggc 1668601 cgcttgggca atgccgactg caagagcagc gatggagatt cgaccaccat ccagcgtata 1668661 tagaaactgt ttaaaccctt ttgttggatc gccaagtaag ttggccgcag gcactcttac 1668721 atcttcaagc aagatttccg ctgtattcga accgcggacg cccattttat cgtacgggct 1668781 cgtaatcgta agtcctggtg tgtcagttgg cacgattaat gcggagatga tgttttttcc 1668841 gtctttgttt ttgcctgtta cggcggttac aataactgtg cgtgcgtagc ttgcattagt 1668901 gatccagcac ttttcgccgt tgattacata ctcgtcacca tttgaaatcg cttttgtttg 1668961 agtgcctcct gcatctgagc cggcatttgg ctccgtcagg ccgaatgatc cgagtgctgt 1669021 gcctgaagcc agcggcgtca aatgcgtctg tttttgctct tctgttccga agtagtaaag 1669081 agggcttgcg cctagcgaga ccgctgcagc atagcttaat ccagtactgc cgcaggcttt 1669141 gccgacttct tcaaccgcta aggcatatga aatcgtatca ccgccagatc cgccgtattc 1669201 ttctggaaat ggaataccca tcagaccgag ttcacccatt tttttaaatg tttgcatcgg 1669261 gaactcgcct gtttgatcta catgttcagc gtgaggagca atttcttttt tcgcaaaatc 1669321 ttttaccatt tcacgcacca tttgttgttc ttttgtcagc tcaaaattca catcgtttcc 1669381 tccttcacat ctttgtaaca tcctattagg cgagttctat aatcattccc tgacaagaaa 1669441 agtctgaaaa ttaaaactga atcatttttt atgtgataat atcagcggga tgagcaaata 1669501 catgcagtag gcgcatacca tccatatcgt aaacgcaata acttggccct ttgataaagc 1669561 cgggaagatg aggggaagat tccaaaggga aatcgtatcc atcaataaac cgaccgctga 1669621 tccccatata cctagcttga tcaccgcgaa ctgtgattga tcgagttttt gatagagaaa 1669681 gaacacaagg cataaaacaa gagcagtgcc cgctcccaag agaagaaagt tcggcaaaaa 1669741 ggcttcttca gccggatcag tcaacacagc atctccgaac agcacaaaaa ataatgtggc 1669801 acctaaccag actagaaatg aaaacgtaaa acacgtcctg tacgtgtttc tcttcgattt 1669861 tatttttatt tagtactagt ttctcagatt ccaataatgg taaatgtcca aacaccgcct 1669921 ccatattcat gtgaatctca cctttgtttt ttaaaaaatt cagcggttta ccatcgtttc 1669981 ctgtcccaaa atcacttttt aaaaaaagac gacttagaaa gccgtccttc tcatttctta 1670041 ttttgttgtt cgtttggaag ctttgctttc gttatgaagc cggtctgctg aagtgacata 1670101 atacgtatat ttcttgttgg gatctgccgt gttatctaag aaggtttgct gctcatgtgt 1670161 ttttctttgc gttgccagca atgttctctg ctttttccct tcggctctgt atatcgcata 1670221 ataggctgtt tctttcgttt tttgatttga tgggtgatct ttaatctgca gaagattgcc 1670281 gtttttgtct tcggtgactt tcgtaagctt cggttttttt ggggcggtat tgtcaagcca 1670341 aggcatttgc ggaaccagtg ccggcttgct gtaaagatcg gtgctgagac tgtctttgat 1670401 gccaagcgga tttttgttga ggtccttgag gctgaaatgc atgcttcctt tcaccagttc 1670461 aagctggcgg ttcaaagtga tttgccgcac atattcctca ggatcggacc aaggcggatc 1670521 aaaattgtta ttgattttat atgctgcctg gccaatatat aagtgaacag gcctattttt 1670581 gacttcattg ctccaccaat cagccagcac gtcgtaagcc gctgcgttaa agccgatact 1670641 ccaataaatt tgcggagcaa tataatcgat gtcgccttct tggatccaat gccttgtgtc 1670701 tgcatataga tcgtcataat ttctgacgcc tgcttttgta ttcgatccgg tcgggtcatc 1670761 tgcggcgttt ctccatactc caaagggact gatgccgaat ttgacatacg gttttgcagc 1670821 tttaattgtt tggttgattt gtttgacaag ctggttcaca ttgtcccgcc gccagtcatc 1670881 gatattagaa aaagcgtctt ttccgtattg ttcgtactgt gcttgatcag gaaattcctg 1670941 tcccgctatt ttataagggt aaaaataatc atccatatga acagcatcga tatcataatg 1671001 ttttacgact tcttcaatgc ctttgacgat aaaatctctc gcttctggaa tgcctggatg 1671061 ataatacagc tggtttccat aggcggcaac ccaatctgga tgttttcttg ccgggtgatc 1671121 ctcagacaat ttattaagat ctgtatgatt cattgtaata cggtaaggat taaaccacgc 1671181 gtgaaattcc aaatttcgtt tatgggtttc ttcaatcata aatgcaagag gatcatagcc 1671241 ggggtccttc ccttggacac cggttaagta ttccgaccaa ggcccgtaag ctgacggata 1671301 aaaggcatca gccgtcggtt taatctgaac gataacggca ttcattccca ttttttgcac 1671361 atcgtccagc agtttgatat actcctgttt ttgctctttc acagataacc cttttttgga 1671421 cggccaatca atatttaata cggaagcaat ccatacggct ctcagctccc tgtcagactg 1671481 cgcattggcc ataaacggaa cggaaatgac aaacgttccg atgatcaagc tgacaaggaa 1671541 acggacaatc gacttttggc aaaccttcat tctgtttctt ctcccccatt acatcacttt 1671601 cactattcgc tattacggta ttcccgggct ataaaagggt gattaacaga atgtctatct 1671661 cactaaataa acgaaaaaag tcctaaagca tgttgtgaac cgcttttagg actttttatc 1671721 attcatcatg gtttgcagac tttttaacac atcaataagt tttacgccga caccgacagc 1671781 cgtttcaagg atcgcttgtg ctccggcaat ggctaaaata aagatcagcg gtattgcaat 1671841 acgaggcaaa aaaagatagc caagtccgat caagatggca caccaaacac cggcacacca 1671901 gtagcaattg agcatgtatc caaagttaga agccggcacg cttttttcat ctacatgccc 1671961 gttttgatca acaatccttt tctttttcat aaaaggtttt cggataaatt ctgtgatttt 1672021 gtcaaataca atcaaatgtg tcagcctgta actggctaga atcagcatga taaaagttag 1672081 aaaagaaaga cggtccattg agaagcctcc aagaaaaagg atgatgttat cattcccaag 1672141 tgtcccttat ccattcttga tacaaaaaga aagacggaca gagaatggcc tctgtccgct 1672201 aatccgagct cattccctcc agttctcata ataagaggat aagaaaatgt agaaaaaagc 1672261 agaaaaatga caataaaaga aattatatga ctatataatc catatatgca ctatattaac 1672321 ggatattttt taaagtacaa taaaaaacat taaattttta taacattttt tttgaatata 1672381 gtattatttc tttatttttc gtttcttttt ttatcaaatt tccggatata aagtgataaa 1672441 agtattgttt tacataaggt cttatacact actttttaat cggactaatt ttcttttgtg 1672501 catcattctt ctaattgttg gaaggttcga caaagcgtta ttacagacat aaaaaaacct 1672561 gttttctctt ggaaaacagg tctcccgcta ttattgattt gccaaaatga cagcgatttg 1672621 atcctcaata tcttttccat cctcttcatc aatcaatcca tttagaagaa tagagaaaac 1672681 aagttttttt ccgctctttg tttctgcgta ccccgataga gagcttaccg tactgagcga 1672741 tccggttttt gctcttactt ttccttgtgc aggagtgcct ttcatgcggt ttctcagcgt 1672801 tccgcccacc attctgtcag gattccccgc aacaggtaaa gaatttagat aagccgagaa 1672861 ccaactctga tcctgaatgt catataacag ctgtgaaagt tgatctgagg atacagcatc 1672921 aatatgtgag attcctgatc cgtcccttaa gacgagtgat ttagaatcaa caccaaattc 1672981 cggaagcgta ctgtttaaca cttcgagccc cttttcccag ctcccttctc cttttttcac 1673041 tttccccatc tcttttacga gcacttcggc atgtccgtta ttacttaatt tcatgaacgg 1673101 cacaaaaagt ttcgataaag gcattgagcg atgagagagc agcacatctg aagaactagg 1673161 tgcttcaccc gtcttgatgt cccctttcac agtaatacct tgttttttta gtgactgctt 1673221 aaataaatct aaggcatatc cggcaggctc ccagacagaa atccattcct ttgtcttgtt 1673281 tgcgtcaacc ggtacgctcc cttcaattgt aatcgtgttt gttccatgct ctctttcgat 1673341 tgtgaggtct ttctctgaac cggcagcagt cgttttagca tcgttcttta tcgttatata 1673401 atcggttttc ggagagacag acacggcagg ctcttcccct tctttttgat ttggggtgac 1673461 ctcaacaatc acagtgcctg catcatagtc ttcgtttgga gacgctgtta gagcggagat 1673521 tggcgcgcca taatatgtgt attcatcgct ccaaggcata tcaggtgata atcgcatgtc 1673581 atcatgccac gtatcatcac cgatcagatt gcctttaatt acttttacgc cggaatgttt 1673641 caatatctca gccattttgt caaaatcaga tggtaaaagt gtcggatcgc ctttcccttt 1673701 caaataaagg ttaccattca gctttttccc tttcagtgtt ccatccgtcc ggacctcggt 1673761 tgtaaaagaa tagttctcgc caaggacaga aagtgccgcg gccgctgtca aaagctttag 1673821 agaagaggca ggcctcattc gggtgtctcc tgaatgttca tatagaacag cacctgtttc 1673881 cgcagagcga acggtgatgc cggccattgc gccttcgagg gcaggatgat cagctaaaat 1673941 cttatcgatc tgcccggaaa gtgcatcttg tttttcagcg gcaagcgcag cctgatgcat 1674001 ataaggcacc gaagcaacga cgaaaagcag taaaacagca acataaagct ttatgctttt 1674061 tttcattaat ttccccgcct ctctgcgctt catcattggc tattgatgat tcagttcaat 1674121 ggtgatactg cttttagctg tcgtttcttc tcccggctcc agcacttgta aaccagtgag 1674181 tgacgaaggt aaatcaagat tcactgcgtt tgtcacccat gtgtaaggct cagggcataa 1674241 atacccttgt tttccgtccg cattgtatac aacccaatgt ttaaactgtt catctgcctt 1674301 ataaataatg ctgatatgtg catgctgatg ataaatgact gcctggtttt ctccgcccct 1674361 cttctgataa gaagataaaa agacatcatc cagctgcttg tggcgcaaat ccattccttc 1674421 atgcaaagct tctttatacg ggacatccat cagcttcccg gtcggcagca ggcgttcatc 1674481 caactcccat tgctgatctg ctgtcaggga gaataacgag ctttctgccg gaaatataaa 1674541 tgtagtatga taaccaattc cccaaggaaa cgcttccttt cctttgttca tgaccgtcgc 1674601 atgtttaaat agggtattct ccttgatcgt gtatgtcatc cgaacgacgg catgatgagg 1674661 aaattgcttc tgcacatggg gaagctcaga aagatcaatt tctgtttcaa caatcactcc 1674721 ttcatcagtt tgcttcgtgg tcacgacatt ccacttttca tggtaaagaa acccgtgaag 1674781 atggttgtgt ttatccttct cgttgatatc aaaatgatac gttctgcccc ggaaactgaa 1674841 tgtaccgtca cttatgcggt taggcgggaa caggattgga atgccataca atgttggtgt 1674901 gtcgtgaaaa ctttctgctg tttccggttc acgcaaaagc tggacatttg ttgttttgtc 1674961 cacgagagaa atgacgttgc tcccccactc agggacaaca atcatttcta gatgttcgtt 1675021 gcccgctttg atggccggcg ttcccaaata cgtgattttc tcaataaagt ttgccatgtt 1675081 tactcaacct ctccttgatt cattgctagt ataagaattc aatgtactgt accatatttc 1675141 ctccatttta tattttcccc tatcaaataa aaaaacaccg ttcaaactta tgaacggtgt 1675201 gattcggagg ctattggatg agacgtgtga tttgtttctt tttccagacg aattgataat 1675261 acccataaat caacagcaag ctgacggcaa acgcagctgg ataaccaacc cagacgccga 1675321 gtatttcaag ctttgtatag tgagaaagga cgaaagcgac aggcacctct actccccaga 1675381 ttgcaaaaat actgatgacg gtcggccata aaactgttcc gcttgcccgc atcgttgcag 1675441 aaataatttg ggcatttcca aacagcaaat agctccacag tgtaatcatc aaaagacggt 1675501 gcgcaatgta aagcgtctct tgctcggtta aaaataacga taaaatctga tgtgaaaaaa 1675561 catagatcag aatgatcagt acgccgccaa tgatataatt cagccaaatc ccaacgcgaa 1675621 tgacctgctt taagcggtca aactcgtttg ctccgatcga ttgcgcagcg aaaatagaaa 1675681 ccgcaatacc aaggctgacg gccggcatct gtacatagct ggccacctgg ttgaccactc 1675741 cgtatgcagc tgttgcatta gagccgtaat gattgacgaa tgaaataacc gctatctctg 1675801 ataatgagac aagaatcata ttgatgcttg ctgggacccc aagacgcagc aggagaacca 1675861 gcagttcctt atccattttc aaataacgac gcactgtttt atcaaattgc agcgggtgtt 1675921 ttcgctttcg taaatacacc attaacacga gaaaagtcgc aatcgtggaa atgacagttg 1675981 catatgccga gccgtatatg cccagtttcg gaaaaccaaa catgccaagg attaaaacag 1676041 gcaaaagcgc gatgttgatg accgtgctca caatcagcgt ataaaacggt gtcttggaat 1676101 ctcctgttcc gcgcaaaaag gtagtatatg caaaatataa aaacataaac ggcatagcat 1676161 aaaataaaat acgtgcatag ttagcgctga catgaatgac attttcaggt gttcccatta 1676221 aacgaaggat atccagggtg aaaatactgc cgataacggc taacacaacg cctaataaaa 1676281 atgtaaacgt gagtgtcgtc ccgacaacag cctttagccg ttcctcattt ttcgctccgt 1676341 aagcttgtcc tatcagaatc gaacttcctg aaccgatccc aatcgtaaat gagattaaaa 1676401 gaaaaaataa cgggaaaaag gatgatacag ctgccactgc atcaacaccg agccatctgc 1676461 ctacagccat catcccgact agctggccga ctgattgcag cacattgctc agcagaagcg 1676521 gcactaaaaa gagtgacatc gaccgccaaa ctgatggttt gcttttcttt tgagttacaa 1676581 gaggttcttg tgatgtttcc atattaaagg actcctttat ttgaaatcgt ttttaaacat 1676641 gccctcattt tttgacaaaa acaggatatg taacatgtta ttattcatca ctgcacttat 1676701 gaaacccttc ccgattcttc taattttaca catcttttta gcttatgaag aataaactag 1676761 caagtaatgg cgtatttttt gtgagtaaaa gaataaaaaa taatttatgc aaaagtattg 1676821 taatctatcc gtaattattg taacatttgt aacataagag aaagagattt tgaaggagag 1676881 agcgataatg aaaaaatgtc ttctatttct aacaaccatt gcacttattc tgtcattaag 1676941 cacaaatgca tttgcgaaaa atacatcagg cgatttatca caaaaacaag cattacagtt 1677001 ggcattatcc gctagagaac atttttggaa caccatgagc ggccacaatc cgaaggtgaa 1677061 aaaagcagtt tgcccatcag gcacattcga gtatcaaaat cttcaatatg tatacatgtg 1677121 cagtgatcta ggcactaaag caaaagcggt gaattattta actcctattt ttacaaaaac 1677181 agcaatcgaa aaaggcttta aagattatca tttcactgtt tcaaaaggaa aacttgctgt 1677241 tccaatcggt gacggagaca atcttttgaa ttggaaaaaa tcaactgcta aactgatctc 1677301 taaaaaaggc agcacaatca catacgaatt tactgtccct acattagacg gatccccttc 1677361 tgcaaaacgg aaagtgacat ttgtgaaaga aaataaaaaa tggaaagtca atcaatttga 1677421 cgcagttata taagaaaaac gcccggtata agcgggcgtt ttttatttgg tttgcataaa 1677481 gaaagacaac aggcgaaaag tgcctgttgt ctttttgtga atataacgct ctaggagaga 1677541 ttcgaactcc cgacctgcag tttaggaaac tgctgcacta tccgctgtgc tactagagct 1677601 tttggtattt atatagtagc tctgatgatc aatattttca agcgatttgt attaaagccc 1677661 tccaaaaacc ttatatgcgg ctcttgtcgt atcttcatca ataccgatat accgcattgt 1677721 aattgatggt gatgaatgat tcagtattct ctgcagctcg gcgatgtctt tcgttcgctg 1677781 ataaaaatga tagccaaacg ttttccggag tgtatgcgtc cctatctcct caagtccgca 1677841 cgctgcagcg gcctctctta aaattctgta ggcctgaatg cgggaaatcg gcttcctggt 1677901 ccgcactgat ttaaaaagat attcgttttc cttcatgtct ttcgtatact cgtatatttc 1677961 ctgtttcagc gattctaaaa taagaatctt tcttttcttt ttcgttttgc tttcagtcgc 1678021 ccataaatga tctttatttt gaacgtcctt cacttgcagc ggcagaatat cagaaatacg 1678081 gagcgcgctg ttgatgccga aaataaacag aaaataatcc cgcttgtttt tgttaagcaa 1678141 atactgtttg acttcttgga ttttctctag actgcgaatc ggctgtacaa tatgcatcaa 1678201 aaaactcctt aaaaaccgtt atgtaacatt ttgaggtcta tgttactatt atagctgaaa 1678261 aacgttgaat gtcaaagtgc ggcggcgttt atgtaacata atatacatag tgttacataa 1678321 gcttttaaaa aagcttcttc caaccttcac cctataaaat aagctttaaa gcctcttata 1678381 aagcttttaa cctcttggat acttatcccc ctactaatca tcaaaaaacc tcttaaaatg 1678441 aaatctgaca ctcccaattt tctggagctt ccgcaaaaat atacaaaaaa agacacaatt 1678501 tcaaattgtg tcctaatcct catcctttac atcaatatct tccgggatcg gttcatttaa 1678561 tatttcctgc acaagtgctt tgtaattctc cagctgttcg agatgcgttt tgaactgttc 1678621 cttataaatc aaaaattgct ccccgtcatg aacggctctg attttccctt cgagcaccaa 1678681 gcttttaata taatcctctg aaagatttgt atattctgct gtttcttcaa tcgttaaata 1678741 catatagcag tcccttctta atccgtatgc tgattctaat atagcacatg gctcatatca 1678801 atataatcaa ttctgcacag aaaaacggca ttatgcacta tataatatac catttgtcac 1678861 ttgtgaaaac gctgtaattt ttttacgcta agattgtaac aatacagctt catataggag 1678921 ggagaacatg aaaagaacgt ggaacgtctg tttaacagct ctgcttagtg ttctgttagt 1678981 cgctggaagt gtcccttttc acgcggaagc taaaaaaccg cccaaaagct acgatgagta 1679041 caaacaagta gatgttggaa aagacggcat ggttgcgacc gcacatcctc ttgcttctga 1679101 aatcggtgct gatgtgctga aaaaaggagg aaatgctatt gacgcagcgg ttgccattca 1679161 atttgcactc aatgtaacag agccgatgat gtcaggtatt ggcggcggcg gttttatgat 1679221 ggtgtatgac ggaaaaacga aggatacaac gataatcgac agccgtgagc gtgctccagc 1679281 aggcgcaact cctgatatgt ttctggacga aaacggcaaa gcaattcctt tctctgaacg 1679341 tgtaacaaaa ggtactgccg ttggtgttcc aggcactctg aaagggctgg aagaagcctt 1679401 ggataaatgg ggaacccgtt cgatgaagca attaattacc ccttctatta aactcgctga 1679461 aaaaggcttt ccgattgatt cggtgttggc agaggccatt tctgattatc aggaaaagct 1679521 ttcacggact gccgcaaaag atgtattttt accaaatggc gaaccgctta aagaaggaga 1679581 tacccttatt caaaaggatt tggctaaaac atttaagctt attcgctcca aaggcactga 1679641 cgctttttat aaaggaaaat tcgccaagac gctttctgac actgtccagg atttcggcgg 1679701 atcaatgaca gaaaaagatt tagaaaatta cgacattaca attgatgaac cgatttgggg 1679761 agattatcaa ggctatcaaa tcgctactac tcctcctcca agctccggcg gtattttctt 1679821 attgcaaatg ctgaaaatcc ttgatcattt taacctttca caatacgatg tccgctcatg 1679881 ggaaaaatat cagctgcttg ctgaaacgat gcatttgtca tatgccgacc gtgcgtctta 1679941 cgcaggtgat cccgaatttg taaatgttcc tctcaaaggc ctgcttcacc ccgattatat 1680001 taaagaacgc cagcaattaa tcaacctaga tcaagtgaat aaaaaaccga aagccggtga 1680061 cccttggaaa taccaagaag gatcagcaaa ctataaacaa gttgaacagc cgaaagacaa 1680121 agtagaaggc caaacaaccc actttacagt tgctgaccgt tggggaaatg ttgtttctta 1680181 tacaacaaca atcgaacagc tattcggaac gggtattatg gtccctgatt acggtgttat 1680241 tttaaacaat gaattaacgg attttgatgc gataccaggc ggagctaacg aagtacagcc 1680301 aaacaaacgg cctttaagca gcatgacccc gacgatttta tttaaggatg acaagcctgt 1680361 cctcacggtt ggatctcctg gcggggccac aattatttca tccgttttgc aaaccattct 1680421 ctaccacatt gaatatggta tggaattaaa agcagctgtt gaagagccga gaatttacac 1680481 aaacagcatg agctcttacc gttacgaaga cggagttcct aaagatgtcc tcagcaagct 1680541 aaacggcatg ggccacaaat tcggcacaag tccggtggat atcggaaacg tgcaaagtat 1680601 atcgatcgac catgaaaacg gcacctttaa aggtgtagct gattcaagca gaaacggcgc 1680661 ggcgatcggc attaatttaa aacgtaaata aataaaaaac tgtactcgct tcaaatgagt 1680721 acagtttttt catgcagatc tttaaaataa aaactgacaa acgtctttat tctgctaatg 1680781 cacgtctatc ttcatctttt catttcgttt atctcatcaa gaaatgtctg aaacgcactc 1680841 gtaataaaaa agtctttcct gtatataaag acgatctcta agtcttgata tgatggtggc 1680901 agctgatgaa tccatacatt tgtacgatgc tcggagccgt caacagcgga ctttgggagc 1680961 agcgccgtac ccatcccggc ggaaacacct tttataatag cctccaatgt gccaaactct 1681021 atgatttttt gattgtgtat gcctgcttcc tctagtaatc ttttgaccct gtcacgatga 1681081 gaacagccag ccccaaaaaa gagcatcggc tgctgaagca tgtcttctgc cgtcccttct 1681141 cgtgatgaaa tcaaaactaa ttcatcatgg gagacatgga gttgtctaac tgcagcgtgt 1681201 tcaaccggcc catatacaaa agcgccatca actttatgat caagaacctg ttgaatcaaa 1681261 tgatgcgtat cagctgtgtt cactgataaa tccacttcag gaaaacgcct gaggaaggat 1681321 gctgcatgct caggcagatg cgttaccgcc attgtttcca gtgatccgat ccgcaaaggc 1681381 ccttttggtt gcctgctcat tcgggtcgat ttttcagctt ggtctaacag cgataatact 1681441 tgatctgcat attgtaaaag attttctcct gcagcagtca gcttcattcc ccgattcgtt 1681501 cgatgaaaaa gcctgatatt caaatcttcc tcaaggttat gcactctggc tgtcacattc 1681561 gactgaacat aattcagcat ttgggctgct ttcgttatgc ttccttcgcg agcaacagcc 1681621 tgaaaaatct ttaaatctcc gctttccacg cgctctcacc tgcttgctat gatgaaaagt 1681681 gatattggct atcatatttg ttcattttac tcgaagaaaa ccgctatgta aaatatgtaa 1681741 agatatgaaa atacaattaa tgaggaggca gacagcatga aagctgtaat tcacaacgga 1681801 aaagccggtc ttctggggtt atcagttcag gacgttccat caacaaagcc tggatacgga 1681861 gaggtaaagg ttaaattaaa atctgcaggc ctgaatcatc gtgacttgtt tcttatgaaa 1681921 aacaaatctg aacaagatcc tcacatgata ctgggttctg acggcgcggg tatcatcgaa 1681981 gagattggtg aaggcgtgaa aaatgttact gttcagacag aagtagtcat tttcccgaca 1682041 ttgaactggg atttgacaga aaatgttcca cctgtacctg agattctggg aggtccttcg 1682101 gacggaacac ttgctgaata tgtgatcatt ccttcacaaa atgcaatcaa aaaacctgct 1682161 tatttatctt gggaagaagc gggcgtttta cctttatccg ctttaactgc atatcgggct 1682221 ctgtttacaa aggggcaatt aaaaaaaggc gagcatctat tgatacccgg catcggcagc 1682281 ggtgtagcaa cctacgcttt atttatggct aaggcgattg gggcaacagt aagcgtgacc 1682341 tcccgcagtg aggagaaaag aaaaaaggcg ctgaaattag gtgctgatta cgcatttgac 1682401 agctacagca attgggatga gcagttgcag ggaaaaaaga tagatgttgt tcttgacagc 1682461 ataggacctg ccctcttttc ggaatacttc cgccatgtaa aaccaaatgg ccgtattgtc 1682521 agctttgggg caagctcagg ggataatctc agttttccgg tgcgttcttt attctttcct 1682581 caggtcaatg ttttgggaac ctcgatggga agcggtgagg aatttcaagc tatgctcgct 1682641 ttcattgaca aacataagct gcggcctgta attgaccgga tatatccttt agaaaaagca 1682701 tgtgaagcat ataaaagaat gcaggaaggc agacagtttg gaaacatcgg gatcgtaatg 1682761 gaataaaaaa agaaaccggc tggcagccag accggtttct cttatatgat aatccccttt 1682821 atttacggaa gaactgaact ccccatcaaa tatcgatcca cttcacgcgc cacttcacgg 1682881 ccttcattaa tcgcccatac gattaagctt tgccctcttc ttgcatcccc tgcggcgaat 1682941 acaccatcga tatttgtttg ataatcccca tatgctgcac tgattttgtt atttactgaa 1683001 ttaacaccga actgtttcaa cagcggctgt tctgtgcctt caaagccgat agcgataaag 1683061 acaagctgag caggccatac tttttccgtt ccaggcagct cgcggaactc gtattttcca 1683121 tgctcatttt tcactttttc catttggatg gtatgaagct ctttcagctt tccgttttta 1683181 tccgcgacca tttttgtcgt ttgaatggag tattctctcg gatctcttcc gaattttgct 1683241 tctgcttcct cgtatgcata ttcaagcgta aagacgtgtg gctgttcagg ccacatattg 1683301 tcattcgtgc gggctggcgg aagtttcggg tgtttgccga attggtgcac gcttttggct 1683361 ttttgacgca gagcggtagc cacacagtca gctcctgtat ctccgcctcc gattacgatg 1683421 acatctttcc ctttggcatc aatgaattgc ttgtctttaa aattagaatc taaatagctt 1683481 tttgttgcaa gtgtgaggta gtccattgcg taatggactc cttttgagtc gcgtccttcg 1683541 attaagaggt cccgctgttt ttgagcgcct gtgcataaga tcacagcatc aaattgctcc 1683601 tttagctcat cagctgtaat gtcaacaccg atttctgtgt tcgtgacaaa atcaattccc 1683661 tcttgcgtca gcaatttaat tcggcgttct acaatgccct tctcaagctt catgtttgga 1683721 atgccgtatg ttaaaaggcc gcccgctctg tctgctcgtt caaaaacagt gacggaatgt 1683781 cccgcttgat tcagctggtc agcactcgcc agtccggctg ggcctgaccc gacgatggcc 1683841 acttttttgc ctgttcgttt ttttggaatt ctaggttgaa tccagccgtt ctcaaatcct 1683901 ttatcgataa tggtccgctc gatgttttta attgatacgg ccggatctga aatcgctaaa 1683961 gtgcatgatc cttcacaagg agcggggcat acccgccctg tgaattcagg aaagttgttt 1684021 gttttcaaca gacgttccaa tgcttccttc catctgcccc ggtagacaag atcattccat 1684081 tcaggaatta agttgtaaat cggacagccg gatgtaaatc cgttaatgtc cgcaccgatc 1684141 tggcaaaacg gtgtaccgca atccatacac cgcgcccctt gccgtttcga tgcttcttct 1684201 gaaaaaggag cagaatattc tttccaatcc tttaagcgag tgagagggtc ccgctccgca 1684261 ggtttttctc gtttgatctc cataaatcca gttggtttcc ccatgttcct ctccccttcc 1684321 ttactgtact accgcttgtt tttgtcccga tgctgctgta ttctgctttg gcttcgtgtt 1684381 ggcctcaaaa gcgaacatga tggcttcttc atctgataaa cctgcagctt tttgctcttc 1684441 gatgcttgcg agcatttgtt tatagttttt cggaatgact ttgacgaatt ttttcacact 1684501 gtcttcccat tgatctagca gatcttctgc tttttggctg tttgtatacg cagtatgtct 1684561 ttcaagcatt gctttgattt gctggatttc tttctcatcc tctaatgatt caaataaaat 1684621 catctcaagg ttgcatttgc gtttaaacgc tttgacatct tcggtcagta cataagcgat 1684681 tccgccggac atacctgccg caaagttttt gcctacatca ccgagaacga caacgctgcc 1684741 gccagtcatg tattcacagc cgtggtcgcc gatgccttct acaactacgt tcacaccgct 1684801 gtttcgaacg gcaaagcgtt caccagcacg cccgttaata tatgcttctc cgcttgtcgc 1684861 accgtaaaaa gccacgttgc cgataatgac attgtcatcc gaagcagagt tgaatccttc 1684921 tgatgacttg acgatgattt ttccgccaga aagccctttt ccgacgtaat catttgagtc 1684981 tccgtccaaa taaagcgtca tccctttagg aacgaaagct ccaaagcttt ggccggctga 1685041 tccggtaaag tgcagcttga ttgtatcttc aggaagacct tcttctccgt aacgctttga 1685101 gatttcactg ccggttatcg ttccggctac acgatttgta ttattgattt caatcgaaat 1685161 atcagcttct tttccagatt cgatggcttc ttgtacggcc gggagaattg ttgtaatatc 1685221 aagtgattga tcaattttat gattttgcgg cgattggaac gtccgcaccc cttcaggctg 1685281 ataaagaagg gtagacaaat caagctggct tgctttccag tgctcctttg cccgttcact 1685341 tgcatgaagt acatcagtgc ggccgatcat ttcatcaaat gtcttgaagc ctaacgcagc 1685401 catgtactca cgaacttctt cggcaatgaa cagcatatag ttcacaatat ggtcaggatc 1685461 tcccatgaac tttttgcgaa gctctggatt ttgtgtcgct acaccgacag ggcatgtatc 1685521 caaatggcag gcacgcatca tgacacagcc gagtacaact aacggagccg ttgcgaaacc 1685581 aaattcttcg gcgccgagca aggcagccat cacaacgtcg cggcccgtca tgagctttcc 1685641 atctgtttct aatacaacac ggtcacgaag tccgttcagc attagtgttt gatgtgcttc 1685701 tgcaaggcca agctcccacg gaagccctgt atgtttaata ctggttttcg gagaagcgcc 1685761 tgtacctccg tcatagccgc tgatcacaat gacatctgca gtcgctttgg caacacctgc 1685821 agcgattgtt cctacacctg cttttgacac cagctttacg ctgattcttg cgtcacggtt 1685881 ggcatttttc aaatcgtgga tcagctgggc taaatcctca atcgaataaa tgtcatggtg 1685941 tggcggaggt gagattaatc cgacacctgg cgttgaccca cggacatcgg caacccatgg 1686001 atataccttg ttgccaggaa gctgcccgcc ttcacccggc ttagcacctt gagccatttt 1686061 aatctgcagc tcatcagcat tgacgaggta atggcttttg acaccaaacc gtccggatgc 1686121 aatttgtttg atcgcacttc ttctatcatc gccgttctca tctggaacaa agcgtttggg 1686181 atcttctccg ccttcaccgc tgttgctttt tcctccaaga cggttcattg cgattgctaa 1686241 agcttcgtgc gcttccttac tcaaggaccc gaatgacatc gcacccgttt taaaacgttt 1686301 gacaatcgat tcagcggatt caacctcctc caacttcaaa ggcttgcggt ttccgtcaaa 1686361 tgcgaacaag ttccgcaaaa atccgatgcg ttcttcatca gccgcttttg tatactgttt 1686421 aaacagattg taatcatttc tgcggcacgc ccattgcaaa gtatgaatcg ttttcggatt 1686481 aaacgcatga tgctctccgc catttctcca ttggaagtca cttcccggtt caagcgtttt 1686541 gctgtaatca tcctgatacg cttcccggtg gcggcgctgt gcctcttctg caattgtttg 1686601 taaatcgatg ccgcctagct gtgatgcagt acctgagaaa tagcggtcga tcacatcgcg 1686661 gctgattcct accgcctcaa agatttgtgc gcctctgtag ctttgcacag ttgaaattcc 1686721 catcttggac atcactttta cgacgccctc agtaatgctt tttccatatt tgctaaccgc 1686781 ttcttcatag ctgatatcca aacggccttc atcaatttcc tgcttgtagg tcgcataagc 1686841 gagataaggg ttaatcgcat ctgcgccata accgattaac gctgcaaagt gatgcacttc 1686901 acgtgcttct cccgattcca caataatgct gaccttcgta cgcagccctt tgcggattaa 1686961 gtgctggtgc agtgcgctta ctgccagaag cggcggaatt ggtgtcagtc gttcgttcat 1687021 ctttttgtct gataaaatta acaaacttac gccttggctg atggctttct ctgcctgtgt 1687081 gaacatgtcc tttaaaccgc gttcaagatc ctctgaaaac agcacatcaa ttttttggct 1687141 ttttaaatca ggatgaacaa tcgttttcaa tgcgtaaaac tgttcattgg ataaaacagg 1687201 tgtatacagt ttaatccggc gaacatttcg ttcacttgga tgaagaagat cgccttccgc 1687261 accgagccaa gtcatcgttg aagtgacaag ctgctcacga atcgcgtcga ttggcgggtt 1687321 cgttacttgt gcaaacagct gtttaaagta gttaaacagc gattgcgctc ggtcagaaag 1687381 tacagcaagc ggagcgtcat tccccattga accaagggga tctttgcctt ctttaataac 1687441 aggaattaga tacttttgga tatcctcata tgtgtatccg aatgccttct ggcgagtaag 1687501 aagatcacta aattgttctt cttctcttga ctccggatca ggatttactt gtacaagctc 1687561 ttcttcaagc catttttggt acggatactc agttgcaatt tgtgttttga cttcctcatc 1687621 ggagataata cggccttctt ccaggtcgat taaaagcatt ttcccaggct caaggcggtt 1687681 tttatataaa acgttctcct gttcaacttc aataacgcct acttcagatg agaaaataat 1687741 ataatcatct tttgtgacat aataacgggc cggacggaga ccgttccggt caaggatcgc 1687801 cccgatttgt ttaccgtcag taaatgaaat agctgtcggt ccgtcccaag gctccatcag 1687861 ggagctatgg tactcgtaga acgccctttt ttccttggac atatgcgtat tttccgtcca 1687921 aggctctgga atgagcatca ttgccgtatg tgccggtttg cgtccagcca tcacaaaaaa 1687981 ctcaaatgcg ttatccaaaa tggaagagtc actgccatca gcattgagaa tcggcaaaat 1688041 cttgtttaag tcctcaccga agctttcaga aacaaattgc tgctcacgtg ctctcatcca 1688101 gttgatattt ccgcgaaggg tgttaatttc accgttgtga accaaatagc ggttaggatg 1688161 cgctctttcc catgtaggga atgtattggt actgaagcgt gaatgaacaa gcgcaaaagc 1688221 agaaacgaat gcttcgtctt gcagatcaga ataaaatgca tcaacctgtt caggtgttaa 1688281 aaggcctttg taaacaatgg tctggcttga aagactggca aaataaaaat caagaccttc 1688341 cgttactccc caattttcag cctgtttacg aatgacatac aattttcgtt caaaagataa 1688401 attgtccttt agatcagaac ttgcgccgat aaatacctga cggacaaacg gacagctttt 1688461 ttgcgccact gttccgattt ttccgacatt tacaggtaca gttctccatc caagaacgac 1688521 ttggccttct tgttcaatta gtgcattgat ttgcttttca attttttttc tttcatcttc 1688581 cttctgtgag aaaaagacca ttcctacccc gtaacgttct ttttctggca gattgatgtt 1688641 tttgcactct tttctaaaga aagcatcagg gatttgaacc agtaagccgg ctccgtctcc 1688701 tgtatccgga tcactgcctt gccctcctct atggtctagc tggcaaagca tcttaagtcc 1688761 ttgtttgaca atgtcgtgag tctgcttgcc ctttaagtgt gcatataggc cgattccgca 1688821 tgcatcatgt tcaaattcag gacggtagag accttgagct tttggcattt gattgtacgt 1688881 cataattcct ctcccccgat caatttccga taataccggt cataaaatct aacaactcta 1688941 taatcattgt aggttttcaa aacgatataa acaatatata atttagatca aaagaatctc 1689001 aaaatgagat agatggatgt gagacaaaca tggagctgcg ccaactgcgt tattttatgg 1689061 aggtggctga aagagaacac gtttcagaag ccgctgatca tttgcatgtg gcccaatcag 1689121 caatcagcag acaaattgcc aatcttgaag aagaattaaa tgtgacctta tttgagcgtg 1689181 aagggagaaa tatcaaactc acgccaatcg gaaaagaatt tttaattcat gtgaaaacgg 1689241 cgatgaaagc cattgattat gcgaaagagc aaattgatga gtatcttgac ccgcatcgcg 1689301 gaacggtaaa gatcggcttt cctacaagcc tcgccagcca gcttttgccg actgtcattt 1689361 cagcgtttaa agaagaatat ccgcacgtcg aatttttgct gcgccaaggc tcctataagt 1689421 ttctgattga agctgtcaga aaccgcgata ttgatctggc cttattaggg ccggtgccga 1689481 cgaatttctc tgacataacg ggaaaaatat tatttactga aaaaatttac gcgcttgttc 1689541 cattaaatca tccgcttgct aaacaaaaaa cggttcattt aatcgatttg cgcaacgacc 1689601 aatttgtatt gttcccggaa ggatttgtac ttagagagat ggcaatcgat acttgcaaac 1689661 aagcaggctt tgctcctctc gtttccacgg agggtgagga tttggatgcg atcaaagggt 1689721 tagtgtccgc aggaatgggc gttacccttc tgcctgaaag tacttttgct gaaacaacac 1689781 ctcgttttac tgtgaaaatt ccaattgagt tccctcaagt aaaacggact gtcggaatca 1689841 ttaaaccgaa aaatagagag cttgcgcctt ccgcgaatga tttttatgag tttgtcattc 1689901 aatttttctc taagctggag cagtatcaat aaaaaaaatg aacccgagct tctatataga 1689961 agcttcgggt ttttttctgc aaattaattt acaggtaaag aaaaatccac atggcaaaca 1690021 aatgcttctt gatcaattag agctctattt gtcagttcct ttttcttttc cggttcttga 1690081 agctgtacag aagagtaatt gacgattcca aggccgattt ccgtcccttt tgaatccatc 1690141 agccgaacaa ctgaaccgct tttgaatttc cctttaatct tctgtacacc gtctaggtat 1690201 aaactcgatt gtccgtttgt tatttttcgt gaacaatcat ctgataaaat catttcacct 1690261 tccggaccgg aattaaaagc gatccattgc tccttttgat tcaacggaag cgttccttct 1690321 gcttcaaaat aggtgccttc cgcctgttca tgaacggcgt ggtataaaat atcgccagca 1690381 tctgcctgac ctaggaaacc tttaatgcca gacgccatta cgattttaaa cgcatcaagc 1690441 ttagagcgca tgccgccggt gccaacgatg cttccagtgt cacctgcgca tgcttcgatg 1690501 tcaggtgtta tttcactcac ccgctgtatc tttttcgctt ctggatttgt gcgcggattg 1690561 ccgtcatata atccgtctat atctgataaa atcacaagca tatctgcatc aatcaatcct 1690621 gcgacttttg ctgcgagcgt atcattgtcg ccaaacttga gccgattgac ggtaactgtg 1690681 tcattttcgt ttatgatcgg gatgatgccg cgctcgagca gtacattcat tgtattcctg 1690741 acattgttgt atcgatattc atcagaaaaa tcgcttctcg taattaaaat ttgggatgcg 1690801 acatagccgt gtgccaaaaa cagctttgaa taagcctcca ttagcaatcc ctggccgatt 1690861 gaagctgatg cttgtttttc tggaagcttc tcgggccttt ggataaatcc gagcttccga 1690921 tatcccgccg ccactgcgcc tgaggaaacc aaaatcactt cataaccggc gtctttgagt 1690981 ttgacgacct ggtcgaccaa cgcttctaat tttcgaatgc tgatttctcc atgaaggctt 1691041 gttaatgaac tgcttccaat cttcacaacg actcttttca tgcttgtatc aggcgtcact 1691101 ttatcactcc tgatagcggc gctgcagttt tttcgatatc ttcgctgatt tcctttgaac 1691161 gcttagccgc atgctttatt gcttgagaaa tcgcttctcc gccgccgctc tttttcaagg 1691221 cttgcagccc cgctgctgtc gttccgttcg gtgacgtgat attatctctt aagatctcag 1691281 gatgttctcc tgtttccatg agcatttttg cggcacctaa aagtgtctgt gcgccgatgc 1691341 ttcgagataa ctgtttatcg aggcccgctt cctcgcctgt cttttcaatg aattccatta 1691401 aataataaaa atacgcgggt ccgctgcctg caattccggt gaatatatcc atttgatttt 1691461 cttggattgt atagacttcg cccatgcatc cgagcaatgc ttcggccagc ttcttcaggt 1691521 cttccgacac atatttgcca agggcaatag ctgttgcaga agcgccaatc atactggaag 1691581 tgttgggcat cactctgaca accggctgtt cattaagcaa tgattgttca ataaaagagg 1691641 tagttatgcc ggcaaggacc gacaatatta attgatgggg ttgaatacgt gattttagtg 1691701 atgacagagc gttttcggcg tcttttggct tcattgccaa aatgagcaca tccatgtctt 1691761 caatacatag ttggttcggc aaggcgcctt taatgccata ttgaagttca agttcagtta 1691821 atcgctctgt attgctgcgg tttgtaacgc agatgttttg tttcgggatt ttgttggctc 1691881 gaacgatacc tgatatcatt ccttccgcca tagatcctgc tcctataaag gctactttct 1691941 tttgatcaaa gatcggtaac atctcctttg ttcgcttttt tgttcgcatt ttcacacgtt 1692001 taaaatgtta ccacgtgagg aaatgatgtc aagtttgaag gccattattg atttgtattg 1692061 tttcttttcg acaaatatgt ataatgaaaa gcagaaaaca cccggttcac actgctgcgc 1692121 cgggtgtttg tttctattaa aaattatctg agagagcttt ttcaatcagt tttttacagc 1692181 gatccagctc taccttcagc tgttttttat atagcttggc agcttcgtaa tctttaaatt 1692241 gatagaggac gacttcctgg agcttagccc cttctttttt tactttaatt tgttttagta 1692301 tcccgtcatc aagaagctca tgcaaagacc ggtatacttc tgtatgattt ggtttaaaac 1692361 caatctcttt aaattcagac cgaagtactt caagcagctt taacccatag agtctctctt 1692421 gctctgtcat cgttatcata taaagcttca aaaatgcgcg ctgtttcact aaaaagcctg 1692481 ttgaactcct tttttcttct ttcatcatat gcactccttc ttctgtcact gacaacacta 1692541 tgtactaaat attcaatttt cttttattgt tttccttctt tatattaaag actgatagtc 1692601 cagttatttc atgtttactg attataggtg tagcggaaaa aataaatttc gactgaacat 1692661 ttggtacata gttttcttag ttctattata gcctgcattt actgctatct tcaatttaaa 1692721 cgattgccag ggtttacata tctcatttta ccggtacgga tttcattcaa ataaaaaaac 1692781 ctgtcgaaag acaggttttc atttttaagg atttgttgac cataatcccg ctgttttgat 1692841 gaaaatacga ggatctaatt tcagttgtgc caccatgtac tcagcaagat cctcaggctg 1692901 cataactttt tcaggattac cgtctgttaa gttcaattcg atagacatat cactagcgac 1692961 agtgctcggc gttaacgcgc tgactctgat attatgtttt ctcacttctt gcataagaga 1693021 ctctgttaac ccgagaacgg caaatttaga agcgctgtaa gcacttgtta cagcagctcc 1693081 tctttggccc gctgtagatg aaatattaat gatgtctccg gctttgcgtt cgatcatttc 1693141 cggaagcacc gcgcgagtga catggtacac acccattagg ttgacttgaa taatattttc 1693201 ccactcatca gctgacagat ctaagaaacc gccaaatttg ctgatgccgg cattattaat 1693261 gaggatatcg atatcaccga gctgttcctt cacttgagct acagcttggt taacctgatc 1693321 ggcatctttt acatctgcag cagcaaatgc agcttttaca ccaagcgctt tgacttcttc 1693381 agccactttt tctacattag cggaagtccg gccaattaac ccgatattca cgccttcttt 1693441 ggcaagcgcc agagcagtag cgcggccaat tcctctgcct ccgcctgtga ttagtgcagt 1693501 tttatgttgt aaactttgca attgaagcac cctttctttg tttacatatg tacgatatca 1693561 cattataagt acaatacatc caatacgcaa atcaaacgaa ctgtgtaaat atcatttctt 1693621 ctgattaaaa aaacggatac agggtaatga cataagaaaa ggagtgaaca tatgattata 1693681 gtttatatca gtcttgcagt attagcagtt tctattatct tcttaggagt taccgtgatc 1693741 caaaacaaga aaaaaataga ccccgcacta aaggagcttt cctctgttac gcaggctatg 1693801 caaaaacaaa tcgaaggatt aaaaacagaa acagagctgc tgacgcaaaa acaaaagaag 1693861 attcagcagg atgtccaaat aaaaaaatac acgcttcagc agaccgcagc tgaagtgaaa 1693921 gaagttcccc aagcagtcaa agaggtgtgg caggcaggac attttaatag cagataagga 1693981 tgaatgagat cccgttgtta cgatcagaat ggacaaatgg gatctcattt ttcgaggagg 1694041 cttacacatg attataaacc gcagctgctt aaaagagttc gcagaaaaag tacattttct 1694101 tccctcttca cttacaaagt ccgatttact tactgatcca tttcgtctcc atcaagaaaa 1694161 cgaacttggc atctactatt cacctcataa tgaatttatc aatcgggatg cctcgcttgt 1694221 gattgccggg atcacgcctg gtttttccca gatgaagaca gcgtacgaaa cagccgccga 1694281 aagcctgctg caaggcggga ctcttgagca aatggcagta gacacaaaaa tagcagcggg 1694341 tttctccgga tcgatgagac ataaccttat taccatgctg gatttatgcg ggctgccgca 1694401 agcttttggc attcaaagcg ccgcaaagct ttttggagaa ttacggcata tgctccatac 1694461 aacttccgtt attaaatatc ctgtctttat ccagcaaaaa aactataccg gatacaaacc 1694521 ggctatcact cattctccta tcctaagcac ttatgctttt gggcacttcc ctgcagagct 1694581 taaccatgtg acgggaccag ctcttctcat tccgttagga aaagcggccg aaacagtgtg 1694641 tgaaacattg atcagacagc acagcctcca gaatttgatt tgccttaacg gctttcccca 1694701 tccatcaggc gcgaacggcc atcgtttgaa acaattcagc aaaaacaaag agcaactaga 1694761 aagacaaatt cgttcctttg ctgcattggt tgatttcgct atagaaaaga ggaaataaaa 1694821 gggatatgat aaacaaaaac acaaacgtgg ggagtggttg aatgtttcct atattagaaa 1694881 cggatcggct tatacttagg caaatcacag atcaggatgc ggaagccatt tttgcttgtt 1694941 tctcaaacga tgaggtgaca cgctattatg ggcttgaaaa catggaatct atagaacagg 1695001 ccatttcaat gattcaaacg tttgctgccc tctatcaaga aaaacgcggt atacggtggg 1695061 gaattgaaag acgggacact aaagaactga tcggaacaat tggctttcac gctctggccc 1695121 aaaagcatag gcgcgcggaa atcggttatg aaatcatccc ggagcattgg cgaaacggat 1695181 ttgcatcaga agtcatttca aaggtcgtat cttacggatt ttctgccctt ggactgtcgc 1695241 gtattggcgc agttgtattt accgataatg aagcatcaaa tcgtctgctt ctaaaaatgg 1695301 ggtttcaaaa agaaggcgtt ttaagacagt acatgtatca aaatgggact ccatatgata 1695361 caaatgtgta ctctattgtg aaaccaagag aatgacggta ttctcttggt ctgtgccaca 1695421 tcccttttcc tttaaaaaga taaaaagcgc ccctcaaaca gggcgctttc taattaagat 1695481 gcatattgag gagatgtttc ctccttaact gctttttcct caggtatatg aatacatttt 1695541 gtcaagaccg cacttgcaag gtaaagggcc gcaaagatcc agacgacacc ttgcgcgccg 1695601 acgagaccga tgaacagcca agcgagtgca gggccgacaa acgctgataa acctgcagct 1695661 aaattcaata cagacatggc tgccccttta tcttttcctg ccaccgtcgg cacaattgca 1695721 ccaatcggca catagcctgc cagcaaaccg ccccaaataa agccgatcac gctgacaacc 1695781 gctaaacttc cgccggagaa aacaggtgcg tagtataata agacggtgaa aatgccgcag 1695841 ccgactccgc cgaaccaaat aacagtattt ttccagccga atttatcgcc gacaataccg 1695901 aagataaggt taaacacaat gttccccagg aaaatcgttc cccaaatttg cagccacaca 1695961 ttggttgaaa ttccatgctg ggccatgtgc atcggcaaaa agactggaaa accatatgta 1696021 ccaatgctgt tgatgattct gatgattccg cctgtaagca cgcgcggatt tgtaaataga 1696081 atcgtaaccc cttttaaaag ctcctcggct gtttctgatc tttttctttt cttcttttca 1696141 aaacggtctt tattgataaa caatgcaaag aatgcaccga gacataccca gaaaatagag 1696201 ctccaaagcg tattcaaata accgaacgct ttgatcgcgt agcttgagta ccaagcgccg 1696261 aacacaaaca tgccgaggca atatgcaatc caaaaccagc cgacagcagt gctcagtttg 1696321 ctttgcggtg ttctgtaaat gacccatgtc aagaaagaat aagcaaaaag cgggtaacct 1696381 aaccctttta cgaagtaagt cacatacatc actggcaggt tcagctgttc aaatccaaat 1696441 acgataaaag cagctgtacc gatcacataa aacaacagcc ccataaacat cgttcgtttt 1696501 gcgccaaatg cttcgagaca tacacccgaa aaccaggaag ctatggcaag cgcaattccg 1696561 tatatactaa aaatggaagc ggactgctga acggtgagcc cgttttcgat caaaaaagga 1696621 ctgagccagc cttgttcaag gccatctccc atcataaaca aaacaacccc taaaaatccc 1696681 caggcaagcc gcttcggtat tcctatttta tccaacatat ctgtctcctc cttagatgct 1696741 attattcatt accgtattac cttattaaag ttgaaaatta aatgattcct caaaacagca 1696801 gaaattccgt cttaaattaa tactttgctt tctgatcctg aaaaaaagcg ctgtgtttgc 1696861 ttccattcct catataaagc caattctatc tgacagtcct tcggttcgat cacccggaca 1696921 tttgctgaca tctcctccgt taattgaaag gtttcattgc aaatgactgc agcaccgacg 1696981 acagatgcct gatgatatcc ctcttggaca tagacctttt tttgaagaag atccgcgata 1697041 tattgagtga gcgctttgct ttggaatccc cctccgcaca cccaaacata atcacgttca 1697101 aacggagtaa cctctgttaa aatgtcaaag ttccatttga ttgaaaatgc gatctcttct 1697161 agcgctgcac gtacaaaatg tgccctcttt aaatgtgctg acagcggggc atcaaaaaga 1697221 aaaccgcctc tcgttaacgc attcttttca gccgataaat aagagccgag agccgctaca 1697281 catgcatggt cttcttttgc aagtgcagaa atctcctcct ccattacttc gtacgtttca 1697341 ttcggataaa aaatctgttt taatttttga taattcaagc cggtaattcc cggattcgtt 1697401 tccacaagcc aatgcccttg atccgtatga cagttcaacc aggctttatg ttttgtgtcg 1697461 ccatgatcct cagtaatttt ggttattggc gttgttgtcc ctgatacaat gacaatgtcc 1697521 tcaagtccag ctccggtgct tttgacagcc agctgtgtat ccccgccccc tgctataacc 1697581 ttagcattta ttgaaaggcc taattcggat gcatattcat ttgctatcgt tccaattgct 1697641 gttcccgctc ttacaagagg cggaaggata gatggagaaa agccgaaaat gtcgcacatc 1697701 tcttctgacc aagtgttttg cttcacatca aatagcaggg tttctgttgc ctgtgatggt 1697761 tcatatgtta atattccgct cagttggtac gtcacccaat cactgatgct tgtaaagctt 1697821 gcagtctttt cccataaaga gggctggcgc tgttttaatc cataaagctt gagcgcagaa 1697881 aaaagtgcag ttggcaggcg gcctgtgctg ctgtatatct cttcccaatc gggaatgccc 1697941 gcctcccact ctcggccgcg attatcgatg ttcggcagcc cgagaaaagg attgccgttt 1698001 tgatcaatca aaacaatccc ctgtctttgg ctcgtcgatg tcaaaccaat gatgtcaata 1698061 tcacacgaac gggatagcgc acgttttgcc aaattcatca cctgcttcca cagcacctga 1698121 ggagaaaaat aacggctgtc cgggtaaagc gtctctgtgg aatactcgat gtcctcccgt 1698181 tcaactgtta gaacactgcc agttacactc acgaccgcta ccctcgcatt gcctgtgcca 1698241 atatcaaaaa cgagatagcc tttttgtttt ttcattctgt tagcctcctt tcttatcccc 1698301 ctgttttcag tgcgtccttg ttatacattg tctgaatatt aagagttttt tcacccttcc 1698361 actttttgag ggctttattc agtatcgtca cgtgatgatc ctccacttca aatgttgctc 1698421 cagcgagatg cggtgttgcc agaacattag gcaatgaaat caattcataa tctgattcct 1698481 ctggaggttc atgataaaaa acgtctagta tcgcaccgct gattttatgt tcttttaata 1698541 caaataaaag atcttcacgg tttacaacaa ctgctcttga agtattaacg aaaatcgcac 1698601 tctctttcat cagatcaaaa tattgccgat ctatcagtcc gagtgtttcc tcagtgcgag 1698661 gcagatggac agaaacgata tcgctgtctg aaaacaccgt tttaagagat gctttttcat 1698721 acaacggatg atcgtcttga atgtatggat cgtaatattt tatcttacag tcaaacgcag 1698781 tcagcagttt tgcaatcctt tgcccgactg cgccgaaccc aatcatgcca accgtttttc 1698841 ctgttagctc atttccttta aatttgacat aagcctgcag gtaatcactg tcccactctc 1698901 catccttcag ccactgattc gaggcgctgg tatggcgcag aaaggaaatc acatttccaa 1698961 taaacatttc ggcaacggct tgtgcattcc gccctggtgt ataaaaaaca ggtatgcccc 1699021 tttttgaggc agctgccaca tccacatttg agggcattcc cctgcaaaca ccgacaaatg 1699081 aaagttcggg aacagaagca aatacgctgt ctgttacctg atcaagttca gtaatcaagc 1699141 ctgtcgcatt tgttgctttt agcagctgaa tgagttcatc ctcccgatat gccctacctt 1699201 gttccttcca agattgataa gcaactgagc caaacaagtt ttcaagctct tttcgtcctt 1699261 cttcgttgta cggtgctgta accaaaaccg tcatgctgca aaacatcctt ttcatcgtat 1699321 ttttcataaa aaaaatctct ttccgaagat ggaaagagat tcatatatag gcgcgctctg 1699381 ttacaggcag acgccggtat aaaccttgct ttcctatctt tcaagctagc gcttgctgga 1699441 attggcacaa taatgttgcc gaggtttcat agggccagtc cctccacctc tctggataga 1699501 aaatattgag tatgtaattt tcagaatgaa gaatacgttt atcataaaga agactcagat 1699561 tgatgtcaat ctcttttttt cagaattgac gttatcatcg gaaatgttat aattcttaca 1699621 aaatatctaa ctagagagag gaactgggcc atgagatctt ttgccacaca acaaaacggc 1699681 attttcaaat ccgtttgctc gctggactgc ccggatcagt gcggattgtt aatacataaa 1699741 aaagacggga aaatcgtaaa agtgcaagga gaccctgatc atcctgtcac agctggaaac 1699801 atatgcaaca aagtccggaa tatgacggag cgcatctatg atgaaaagcg gctgactaca 1699861 ccgctcaaac gaacaggtgc gaaaggccaa gcgatatttg aaccgatttc ctggaaagag 1699921 gcaatcgata cgatcacctc ccgctggaaa cagctgattg atgaagaggg agctgaaagc 1699981 atacttcctt acagctttta cggaaatatg gggaaattga cagctgaagg aatggaccgc 1700041 cgcttttttt accgcatggg gtcaagccag cttgaacgga cgatttgcag caaagcggga 1700101 tctgaaggct ataaatatac aatgggcata agcgcgggaa tcgatcctga ggaaaccgtt 1700161 catacaaaac tatttatttt ttggggaatc aacgcggtca gcacaaatat gcaccaaatt 1700221 acgatcgccc aaaaagcgcg aaaaaaaggt gccaaaattg tcgtgatcga tgtgcataaa 1700281 aatcaaacag gacgtcttgc agattggttt atcccaataa aaccgggaac cgacagtgca 1700341 cttgctcttg gcatcatgca cattttattt aaagaaaacc ttcatgatga agcatttctg 1700401 tccgagtaca cggttggcta tgaagagctc cgtgaacacg tgaaacaata tgatcctgaa 1700461 aaggtatcga cgatcaccgg tgtcagtacc gaagatattt accgactggc aaaaatgtac 1700521 ggggaaacct ccccttcttt tatcagaatc ggaaacggac cccagcatca cgataacggg 1700581 gggatgattg taaggacgat tgcctgtctt ccggcgatca ccggccaatg gctgcacaca 1700641 gggggcggcg caattaagca taacagcgga attttagaat ataacacaaa tgccttgcag 1700701 cggcccgact tattgaaagg gcgcaccccg aggtcgttta atatgaatca gcttggcagg 1700761 gtgcttttgg aaacagaccc gccgattcgc tctctattta tttacggaac gaaccctgcc 1700821 gtcgtcgcgc ccgaagcaaa caaagtcaga cagggcttgc tgcgggaaga cttgtttact 1700881 gtggttcatg atttgttttt aacggaaacg gctgcatatg cggacattgt actgcctgca 1700941 acatccgctt ttgaaaatac tgatttttac acctcctact ggcaccatta cattcagctt 1701001 cagcagccgg tgattgagag atatggggaa agcaagtcta acactgaggt tttccgatta 1701061 ctggctgaag ccatgggatt cacagaccag gagcttaaag attcagatga agtattaatc 1701121 cgccaggcgc ttgaccatcc agataatccg catttggcag agattgatta cgattcactt 1701181 actaagcatt catttatgaa agcgaaacgt gaaaagccgc tgtttccggg cgaacttcca 1701241 acgccaagcg gaaaaataga attatattca gaaaaaatga aacaagacgg cttccctgct 1701301 ttaccgacat atacacctct tgtaaccgat aatgaacatc cgtttatgta tgttccgggg 1701361 ccaaaccata atttcttaaa ctcaacattt tccaataatg aaaaacacat caagcttgaa 1701421 aagacgccaa agctctttat caacacaaaa gatgctgaaa aacacggaat cgttgatggg 1701481 gcacctgtac gaatttggaa cagccgggga gaatgcgagc tgaccgctgc agttggagaa 1701541 caagtgctgc caggtgtcgt tgtcagccaa ggattatggg cggatgaaca aggaaaaaaa 1701601 cagcttgtaa acgcgctaac cccagatcgc ttgtccgata tgggcggcgg cgccaccttt 1701661 ttttcaggcc gtgtacagat tgaaaaggtt tgaaaaataa tgaaacccgg agtatgccaa 1701721 gcccgtataa cataacatcg acataatgga ggcatacaca tggacgtttt tttaggaatt 1701781 ggtattgctt tggctggata ttttatcggt gaaggcttaa agcagaggaa ccaaaccaaa 1701841 ggtaatgaac aaaatgatat cttcctaata aaagaacggg atatttactt ttacattgga 1701901 ctttttttag gaataacaac gactgaagca aaacagttag ctggagacat ggcagacctg 1701961 ccttacatcg aaataaacgg aaaaaaatat gtccagaaac atatgttaaa agattggaca 1702021 ttcacattag ttgaaaaaca tcagggtgaa taaaacaaat ctgaggagag cgagattcat 1702081 tgtcacgctc tcctctgttt agctgtatgg atcctgccac caaaactttg tgctataagc 1702141 gctgataaaa cgataaacca ccatctatgt tctttcctca aacaactcaa gatgcccgtt 1702201 ccacaacaat agtttttata ttcctttgat gacgtgatgt tcttgatgaa cgtatgtatc 1702261 gtaaaacact tagaaaacct attcggtttg aatgtgtgct ctcattatgc ccccatactg 1702321 cgcctttatc cgcggaggat ttttttaaaa aaatatgaaa cctaaagctt ttagatcctg 1702381 aatttttatt gaacctccat atttctccga ttggtaaaaa ttagcctata caccggaagc 1702441 tgtacgttta taaaggatca gagaatccca taaccagtaa atcactgcag ccgcaatact 1702501 taacatataa taaaagtacg attgcaatgt ccatgctatt gacgcaggtt cattgataac 1702561 aaaaaacagg aaagctgcga taaaagcaac cacactgtaa atcaataggt acatgacatt 1702621 gaaagttctc gcttttttct gcaacttcat ttggagcgga acagcaaaaa ggccatacac 1702681 cacaaaaccg tataataaag caattgctgc cgtaaacaat gcaattatca tatcgccata 1702741 cataacgaaa gaataaaacc ctaataacaa accaaatgta aggctggata gccctaatgt 1702801 cattaaataa tatgatgcga tttttttcat tttttcaccc cccttgtttg atttattcac 1702861 agtgctgtta gtataaattc acaacctttg tatttctttt atcgagatgt cttccctaac 1702921 gtgctatacg caatgcgcta ataaaaggtt tcaaaaatga cgttctttta ttagataata 1702981 cgctggctga aaacgcctct cctgattggc caaagcgcga atgaaaaaag tgcatgaata 1703041 cctgcccaac agacagaata agaagagttg atatttcaac acttttcgta aaggggtgaa 1703101 accaatgagt aagaaaggta ttcaaaattc aagtattgaa caaataagaa atgaccatga 1703161 gactgaaaca gcttttaaag cagatgatcc taaaaaacac ggttccgatc ctaaaagaac 1703221 gaaataagtt cttaccccca ctaaaatatc aataatctgg aggaagtaaa gtgactcaaa 1703281 aaaacggtgc agacagacct gatgattata aaagattttc ttcattagac aaggaatatg 1703341 attttcagca atctatacgc agcaatactg agacagaaag tgtaaacact gaaacacaaa 1703401 ctcataacaa agaaaacaaa aatgacacaa cagatgttgc cgggaaatac tttgagccct 1703461 cagattataa aggaagcacg caattagaaa aaggattggc tgaaactcat gaacaggtca 1703521 gcgatgacta ttttgaaggg acaatcgatc aaaatttgga ctagccatac aaacggaact 1703581 aacttaaaag aagtcagtta actctgtttt tagaaacaac cacagtaaaa gtagccaacc 1703641 cccaccgaat aagatggggg ttgcacgtaa gtagcctgtt taatatttaa aacgattaat 1703701 gacggtttga agttcttctg ccaactgaga tagagattct gcggcatagg agatttcccc 1703761 cattgaatga agctgttcct gtgatgaatt tgcaaccgct tctgtatttg ctgacgtttc 1703821 ttttgtacca gcagccaatg tatgaactgt gtgctgaatc acttcaacgc ctgaagtaag 1703881 ctgttgagtt gctgctgcaa cttcttgtat ttgagaagtg acctgttcca ccaggttcag 1703941 tatttcattg aaatttcctg ttgtctcttg agaaagaaca atacctgagc tcacattttc 1704001 ttgaacaact ttaatattat ttaccgtttc tatcgattcg ttttggatgg tcgctaccac 1704061 cgattggatg tggtttgcag atttatttgt ttcatccgcc aacttccgaa cttcttctgc 1704121 caccacagca aatccttttc cttgctctcc ggctctggcc gcctcgatcg ctgcatttag 1704181 tgccaacaaa tttgtctgct ctgaaatcgt cgtgataagc gaagagatat cgctgatttc 1704241 tgctgtgctc gctaccaatg tttgcaatcc attgccggct gaatctacag atttatcaat 1704301 gaatttcatc tggtctaaca tcttgttgac ggacttagag cctatttcag ccttgtctct 1704361 catcgaagaa gaaagatccg ctatgttccc tgtatttgaa gcgactgatg atatactgtc 1704421 taataattca gtgatggatt ctgcgctctt ttctgtcatt gagctttgct tcacattgct 1704481 gtcggcagcc atctgcatgg ctcgtgaaat atgttcagat gttgatttcg attcttccgc 1704541 gcttgccgat aattcttcag aggaagcggc gacttgttca gatgagctgc tgatctgctt 1704601 cacaatttga gttaatgaat gagtaaaaga attaaaagat tgggcaagct ggccaaattc 1704661 atctttattt ttcacaatga cttttttggt taaatcagcc tcgccgtgtg caatttcctc 1704721 cagctgctta tttatgcttc ttagtggcac cataatggac tttaacagca ttatgcttag 1704781 aacaatgcct aatattactg atatccctgt gacaatgata atgagcgatt gactcatttt 1704841 cccattgccc tgtatttcat cctttagatc ctctacctct tgatccaggc gatcagacag 1704901 cttattgaca gccggagcta cgccttcttt tcttattgtt ctttcttctc caaaatggat 1704961 ggtttctgct tttttaggat ttgaagagta ggctgttact acttgctgat tcaaagctct 1705021 atactgagta aaacttgtct taatgtcttc aatattggat tgatacttct cttcatcaat 1705081 caagtcatta acccggtcaa ggctctttaa gacatcgtct gcttttccct tcataccctc 1705141 gtcgtattct ttgtctctgg taatcaagaa gcctctttca tcatttgata acccggtcaa 1705201 ttcatattgg atgtgtttta tctctttttg gaattccatt ttgtctttaa gttcttcatt 1705261 ctttttcaca gtagaagaaa tcataaatac tgaggagcct ccaattccaa taattgaaac 1705321 aactaatatt gatataatcc ccagcaattt tgttttcact ttcatgtgtc gttttccctt 1705381 tccgcacaat gtaatggctg aaataaaata tgttcaagcg cgtttgaatc caattcgctt 1705441 acgctcatgt ccataatatc gacacgtgtt atcaagtttt atagtgatat tcttatatga 1705501 ataagcaaat tctttacgtc tctgaactta cagaaaaacc ttaagtaaaa tttgcagtct 1705561 tttgcggtat gtaagtcact cttattcgtt tttctaaaaa aggcttttcc cacctcaaat 1705621 tggctgaacc ggctgttttc tcgaaaatat aatacaatac gcagcataat atgaaggagc 1705681 gaaacttaaa tggggatcat caatggtaaa gaattcattg accgattgaa taaactagaa 1705741 aacgaaatat ggtatgatgg cgaaaaaata aagggtaaca tttctgagca tcctgcattt 1705801 aaaggaataa tcaaaacaaa aagctcactt tatgaattgc aaacaaagga tgagttaata 1705861 catgaaatga cttattgcct tcctggagat cataatcgaa tcggcctttc ctatctccag 1705921 cctaaaacaa aaaatgattt gaaaaaaaga aggaccatga ttgaacattg ggctagacat 1705981 actcatggaa tgatggggag aagtccggat tacatgaata cggttatgat gagctttgct 1706041 tcgtcagcgg agcttctaaa agataaagag aattgctttc ctgaacatat actagatatg 1706101 tatgaacaag ctgctaagca tgacctttcc tttacccata cattcattac tccgcaagtg 1706161 aaccggtcac agtcctattt tgggctaagt gaaaaaccga tatctgctaa agtcattgat 1706221 agaaccgaaa aaggtttaat gattcatggc gcacgactgc ttgccacaca aggcgggttg 1706281 accgatgaaa tcttggtttt ttcagcgcct aaatttttct ttgaaacaga tgaagcttat 1706341 gctttttcaa tcccttctaa tacaaaaggc gtaaaattca tcacaagaga atcatttgta 1706401 ttaagcgact cttcctttaa tcatccctta agctcaaggt atgaagaaat ggattcaatt 1706461 gtggtttttg atcatgtgtt agtgccgtgg aatcgtgtgt ttttttacga taatgtggaa 1706521 gcagctaaag attttatgac aaaaagctct tttcatgcct ttacctttca ccaggttgtc 1706581 attaggcaaa tgataaaaat tgaatttcta ttaggtgttg cacagcttct tgtcgacacc 1706641 attaatgttt ccgaatatca gcacatccaa gaaaagctct cagaaatcat tgtgggattg 1706701 gaaacaatca aagccctcat tgacaaatcg gaaaatgatg ctcagttaga tgaattcggc 1706761 tatatgcgcc cctgtttaat tcctcttcaa gtcatcagta cgatcattcc taagctatat 1706821 cctcgattta ctgaaatcat acaattaatt ggagctagcg gaatggtgac actgcctacc 1706881 gaaaatgcat ttgactcaga gatacgggaa gatcttgacc aatatcttca agcaaccaat 1706941 acaaatgctg aagaacgtgt gaaaattttc cgtttggcat gggatttaac aatgagttca 1707001 ttcggaacta gacaaactca ctacgaaaga tattttttcg gagatcctat tcggatttca 1707061 agcaggctgt ataccagtta tccaaagcag gagcagttga acatgattaa aacattttta 1707121 catgcagata cagaacattg aaaaaacagc gggaaaagat ccgctgtttc gtatttttta 1707181 ttcaggaaac tgaacatggc ccggtactgt ataggctttg gacgttccgc tttcaggcag 1707241 ctttggaatg gtgtctttca caacttttcc gcggatgtca gtcattctga ctttgagaga 1707301 gccagtacct aaattcgtac tcacaaaatg gttatagtcc attttctcca tgttgatcca 1707361 cttaccatcc ttttcatatt ccattttcat aacaggatac ttgtgatttc tgacttggat 1707421 tgctgcccac cacctgctgc tgccttcttt gatccggtac gtgaaattgc cggtgattgg 1707481 ggctttgaca acacgccatt taatattgat ttttccgtct ttcatattgc cgattttacg 1707541 gaaggcatta ggtgacagat caagagctcc ccgagcgcct tcgggataaa gatcagtaac 1707601 atatacggtt gttttccctt ttggcccttc aacttccaaa taagagccgg caagtgccgc 1707661 ttttactcct ccgtaattga gatccgccgg atttattgca gtaatctcca tatcggaagg 1707721 aatgggatcc agcaggaaag ctcctcctga atagcctgac cctgtatacg ttgcataacc 1707781 ttcatgcagg tcgtcatatg ctgccgaagc ttgcggggaa aaacagaaga tcgtcaacaa 1707841 aaccatacca acaaatgcac tcatgatctt tttcatattt ggtcctcctc aaaccagact 1707901 tcaaatgaga atcattatca ttataagact caatccatct ggtttgaaag aggaaataga 1707961 ttcatagttg attttaaggc aaattcacta tcattcatat atcaaatgta ggtacttatg 1708021 aaaaagccaa tacaaatgaa cgaatgtgca cttcagccga atgtcttatt tttccctctc 1708081 aaaattcgca tttcaataac gaaatgaaac aggctgttgg cctgataaca gctatacagg 1708141 aaaagctatt tttccccgct cagtttcaac ttagctgtca tcatgatgcc aaagatcagc 1708201 acaatcggaa cccaaataat gaagtgataa aaatcaggct cagccagagc aacaataata 1708261 gcccctacac aatacaaaat aatagccagt gctcttaaca cagtatctct taagaaagtc 1708321 ttcttttgct tcttaaaaaa caaacggccg gatatatcct ctaaaagaga agccaaagtg 1708381 ccggtcaaca cagttgaaga aatacctgca atccccagtt tttttgctgc tgtagtttga 1708441 atccccatag aaatgctcat gagtataatt agaatgtgca caggaacaaa tgcccggtaa 1708501 aaagaaagac aagcaaagac aaacaaaatg aatgcttcaa gtgcgagggc ttttgtcaca 1708561 gcagaaggcc aaagggtatt ttccgccttt ccgaccatca atgtagcaat gatcacgccg 1708621 catataaatc cgattagcgc agtcaaggaa ttaaaaacag tgacctgaat ggatttgccg 1708681 atagctaacc ccaataatac aatgtttcca gtcatattag ctgtgaacac atgtcccagg 1708741 cttaaatacc cgattacatc cacgattcca gctgttaaac ataaaagtga tagcaaggtg 1708801 tttcgataag ctgctgcagt caacggtgta tcaatccttt cttctatttc aattgttagt 1708861 atgtcttttg gcgcaatctc tattttttaa gtaacccaac attaattagg aagatagaac 1708921 ctattattcc tttccattaa ctgtaataat aatccccgca aggaaatgat taaaattgaa 1708981 aggaagcata ttgtgatgaa acgactttgt ttatggttca ccgtctttag cttgtttttg 1709041 gttctcttgc ctggaaaagc attaggtgca gtcgattttc cgaatacctc aacaaatggc 1709101 cttttaggtt ttgccggaaa tgccaaaaat gaaaaaggca tctctaaaac gggcacaacg 1709161 ggtggaaaaa acgggcagat tgtttacatt caaagcgtaa atgatttaaa aacccatcta 1709221 ggaggatcca ctccgaaaat tttagtgctt caaaatgatc tttccgcatc tgcgaaaaca 1709281 acagttacca ttggctcaaa taaaacactc gtgggctctt acgcgaaaaa aacgctgaaa 1709341 aatatttatt taacaacttc atcagctttt ggaaatgtca tttttcaaaa tttaacgttt 1709401 gaacacagtc cgcagattaa cggaaataat gatatccagc tttatttaga ttccggtatg 1709461 aactattgga ttgatcacgt cacattctca ggtcatagct ataatgcaag cggaagcgat 1709521 ttggacaaac tcgtgtatat cggaaaatcc gcagattata tcacgatcag caactcaaaa 1709581 tttgcgaatc ataaatacgg tttgatttta ggatacccgg atgattctca gcatcaatat 1709641 gacggctacc cccacatgac aatcgccaat aattattttg agaacttgta tgttagaggc 1709701 ccaggtctga tgagatacgg ttactttcat gttaaaaaca attacagcaa taattttaac 1709761 caggcgatta caattgctac aaaagcaaaa atatattccg aatataatta ctttgggaaa 1709821 ggcagtgaaa aaggcggcat ccttgacgac aagggcactg gttatttcaa agacataggc 1709881 agctatccat cactcaacaa gcaaacctct ccgctgactt cttggaatcc tgggtcaaac 1709941 tatagctatc gtgtccaaac gccggaatat acaaaagaat ttgtcacgaa atatgccgga 1710001 tcacaaagta caactctggt atttggctac tgatataaaa gaggccctgc gttaaaaacg 1710061 ctgtgcctct ttttatacta taggctattt ttaagcgatc cttgtaattc catcaagatc 1710121 cagcgtcggt caaactaaaa agcatatgtt cttttccaca ataacttctt aactggcttt 1710181 cttattatac cagtttatcg caagtgaaaa gaaatcattg ttctgaacct gtattaaatg 1710241 aacgatcgtc ccacaaacta cttaaaaacc cctaaaaagg atgatggata tgtgcggcag 1710301 gtttactttg tactctgcat ttgatgatat tattgaccag tttgacatcg atcaattttt 1710361 tcctaaaggt gaataccagc caagctataa tgtcgcacca tcacaaaaca tccttgcaat 1710421 catcaatgat ggatcaaata atcgcttagg caagcttaga tggggactta ttccaccttg 1710481 ggcaaaagat gaaaagatcg gttataaaat gatcaatgct cgagccgaaa caattaccga 1710541 gaaaccggcc tttcgaagac cgcttgtcag caaacgctgc atcataccag cagacagttt 1710601 ttatgaatgg aaacggcttg attccaaaac caaaatccca atgcggatca aattgaaatc 1710661 atctgctctt tttgcgtttg ctggcttata tgaaaagtgg agcacacatc aaggataccc 1710721 tctttatacc tgcaccatca taacaactga gcctaatgag ttcatgaaag atatacacga 1710781 ccgaatgccg gttatattgg cccatgatca tgaaaaggag tggcttaacc ccaaaaatac 1710841 aagccctgat tatctgcaaa gtttgctgct gccttatgat gctgatgaca tggaagcata 1710901 ccaggtttca tcattagtaa attcacccaa aaataattca gctgagcttc ttgatgcaga 1710961 aaatcatatg tagtgattga aaaaattctc tagcaagaac ttgtcaaata gctttgttcc 1711021 ttaggtgcca atccctctag taattatgaa tatttagtac atagatcaat tagttatctt 1711081 tagcatcagt ttgaaataat tttattatgt aaacttaaat aagcaatgtt attcctttca 1711141 tataaaatag tttacatttt tataaaatcg cttcactttt ctattttgtc agcaaaaaaa 1711201 ctgaaccaca ttaaacttat gaaacctgcc gcacctgtgg attgcaaata tgatataagc 1711261 ccatagaggt aaatccatac actttccctc ctaagaatta aatgaaattt ctttcatctt 1711321 acatgaaggt cttctttctt ttgtttatcc agtgtaatac ttaataatat gttgatgaat 1711381 gcagctggaa aatatataaa tcccactcca agaatgccta gtatcgtact taaacttact 1711441 atgtaattct ttgtcatcgt ttgactgtca atcaatatta gaagtgaaat caatccagct 1711501 aaaacaccta taaaccaagc atcgccaaca gcataagaat catccagcat ccctaaccat 1711561 cgccccaata tagagctccc aatggcagtc aaactggata aaaatatgag tgctttcatt 1711621 tcttctcctc ctttaaagcc aatcaaactg gtagaaatcg gccattgaat ccccattatc 1711681 gaatggttac catttcattt ccacattaac attttaaagc tcattacaat acgattcaag 1711741 cagaaaaacc ctacataacg tatatatagg gatttaataa aacacaggcc aaaattcagc 1711801 tctatctact ttaaaaagat atgaagggca gctgtgtgat ctgttacgtc tttacgtacc 1711861 gggatatttc acaacaggca ctttcttctt gcgcagagaa tcaagcatga ctgatccagc 1711921 attcaagttg ctttgtacta attctttagg cgtcaatgcc atccactgat tgagtgacac 1711981 atctgcatag cggttacttt tgaacatttc taaaaaccat aatgtttctg taccagtgtt 1712041 ttgtatatag tgtccggcat tagaaggcac gtatccaacg tcgcctgctc tataatcaaa 1712101 tgtgcgggca gtcccatttc cgataaatac cgtcattcgt ccctgtcctg ttagataata 1712161 ttgccactca tcgctattgg gatgccaatg aagctctctc atcgcgccag gctcaatctg 1712221 aacaagtgca gcggctatcg tttttgaaat tgggaagtta gaagaatcca caattcgtac 1712281 actcccccct ggcatttgaa ttgggggttg atttaacagc tcgtgtttaa aggtcatggg 1712341 gacttttcca tatggtgact gaatgtcttc actggcgact gatcccggca cattcccttg 1712401 gtagatatag acttgctcag acggaagaga gttgaaagca ttctccggga caccgaaatt 1712461 tgcagacaga acatcttttg gtgtgtgtgc aagccaatct gaaatggtta acgttgaaaa 1712521 ctcagaaaag ttcccatcat cgaaaacgag cagaaactcg cagtgttcca atccctgtat 1712581 ggaatgcgga attcctgccg ggaagtacca aaggtcgccg ggaccaacat cagcaatgaa 1712641 atttcgtccg tcttggtcaa cagcggtgat acgtgcccgt cccaaaagca tataagccca 1712701 ctccgcttgc ttatgccaat gaagctcgcg gacgcctccc gcagttaagc tcatgtttac 1712761 acctgcaatc gcagtcgaaa tcggaagctg tcttacggtg atttctcttg accagccgcc 1712821 gtgatctaat ttcatgggag cgtctgagaa tgaaaatctc aagttaggaa tcataccctc 1712881 atctgtaaca ggcggaacaa atatattcgg attttgaata tcccgtatta tatttcgcgg 1712941 gcctgtatca atagctccag ctccatcact tcgaataggc tgcggcacgt ttctgtcttc 1713001 atgattgatt ggttgttgtt ccaacagcat gcacctcgtt ttagaaatga acaagatttt 1713061 atttcagcct atgcagaatc ttagattgct gtgcctagga atccgcaaat aaaaaagtga 1713121 ccaccaatgt gatcacaaat acatcaaata aactattttt tataccatgg cttcttatgt 1713181 aatttgattg cttctgtctg ttttttctgg cctgtcctcc actccacttt tactaataca 1713241 tcatgaccta tcacttcatc ttcaggcata taatcaaagg tggaaatatg gtcctccatg 1713301 cgtcccccac ccggcatttc atcacctgtg tactccgata agtcgtactc atctacgtta 1713361 tcatcttgat acttttcgcc atctacatac agagtaattc tttcaacaac agtccacttt 1713421 tcttccttct tactcccctg ccaatataga tttagaaaat aattgggtcc aattgaagtt 1713481 ttgtctgatt tttcaaggtt agacatccac agtccgcttt tcccgctgcc ctcatatttc 1713541 actttgttcc ctgacaccat tacaaataat gtgatgatgc agatgatcaa gaatccagca 1713601 atgatcaata gccatttctt aatattgttc ttttttctca tgtttttcct cactttccta 1713661 actttttagt aggaaaatac gatcaaaatg ttaccgaaaa gaaaataaga aagggctaat 1713721 gatctaacag atgactgtct aaacttttga cttaaattaa agtgctttct aaagacaaga 1713781 ttaaaacgta taacagctct taaatgcatt ttttgtttca ttgagtcaag aaccttaaaa 1713841 tggcttttta ttattaaaaa tcaagctagt gtattaagta acttttcaaa tttatttata 1713901 ctcatgatct cgtgagtcac aaatctccca tcaaaaaaaa cgctaaaagt tgtccaaata 1713961 gctggtgact tttgtgcctc ttctttcgat gataactgaa ttgactgaaa ttgaacccct 1714021 ttcttttcag tcaattcccg caaatcattt atcatgccca ctgcaaacgg acactgagct 1714081 gtatagtata tcgtaatccc cttttcattg atagaatcac ttttcacctg gctcttaaat 1714141 gcaggagaat ctgcaaggcc attccaagtc aaagccatta attgaaaata aggggcagct 1714201 tcatcttgta gagtaaaccc catatgctca aagaaatgct tatcacttaa atagggcagt 1714261 tttttcttgc ctgcgatatg gataatgcca tccatgccgc acgctttcgc atctgctata 1714321 catttgtcca acaatcgttt cgcatgaccg ttatttttat atctgccaga cacccacaga 1714381 caattaatgt acataaaatt aggcgcattg ataggcaccc atgcctcatt cgcaggtagg 1714441 tattcaataa agacttttgc ccgttcatgt aagcgataga acaccaatcc ttcatccatt 1714501 cgagctttga gccatctctt cttttcatta actgcatgct catattgttt cgtgcttaat 1714561 gcacagcaaa tatgattgtc ttcaatattg tcctttgtga tttcaatgta gcacatctcc 1714621 tctttccccc ctttaacata attacatgga attcaacttc acactttaca tgcctaatag 1714681 aataaatacc cgttccaact taaatacttt ttcttttcca ttttgccaat taactgtaaa 1714741 acccttcttt tattcagata ttatcttgat tcctatatca cccatttcaa atccaaagtg 1714801 tgttcatctt tgaggattag atgcactgct tatgctataa atacagtaca cgaagttttt 1714861 tatttgaagt aatatttgtt acgggacagc aatagtaaat aagtgataaa aggggaatta 1714921 aacttggtgg aaaaatgtta ttcttgttta atttgcggat acaaaggatt aattcaaaat 1714981 cctttgtata aaggcgagta tcaaaaaacg tttgacattt gtccatgttg cggttttgaa 1715041 tttggctaca gtgaggatca tgatgtgagg ttaggtttta ttgtaactcc tgatcattta 1715101 attgaggctg catttcaatt gtatcgcaaa caatggcttg agagcgggat ggtaattgct 1715161 catccggaag atattccaga agaattgaaa aatggcaatt gcttaaaatt tgaagttttg 1715221 ttgaaacaat tgaaaaaact aaatcttgac atagaaaatt ttgaaattag cggtttttaa 1715281 tgatgaaaca ggttgcactt gtttaggttt cactgtcatt atcagtaaaa tgttaagttg 1715341 aaatgcgcaa tcagtcacaa agtctctatt cgtattcaat aaagactttg tgatcatcga 1715401 caaacatttc actcccatcg gataaagtat ccaaaaggcc tcctctggtt cttctctata 1715461 gtcattaatc acagtcactt tgacatttga ctcagctatg attggttttc caacaatttt 1715521 tcgttttttc ctcaggcaaa gtaagagatc gaatcatcaa agccattcca tctttactgt 1715581 ctaattaacg ccatcttcag tgaatttaaa ggtctgtttt aaattgcgtc cttcttgccc 1715641 cttctgtgtc caaattataa caacctctaa ttcagaggcc ttatctgcca gcataaaatg 1715701 attgaacttc agcggtgagc catcatttaa actttcagct aacattttag aatcttcttt 1715761 tggtttgaca caattttcat cgggacatcc aaaaagcgaa aaccttgtga ttgaattagg 1715821 gtcatttcta tacaattgca catccactgt agctgctttt tcccctatat ttttgacttc 1715881 caaggaatat acttgatatt ctcctttatg aggtctcgta aattccttta cattttttgc 1715941 ttcacttact tttactgacc actggtctgt tttttgtgta ataggcaaca ccgtaaaagt 1716001 cagggcatgc gcttttgatt ggcaaaacgt aaatccaact gctgtaaaaa caattacaga 1716061 aaataatacc cttttcactt catttatccc tccttccttt cactggccgc tccttaaaga 1716121 attgattttg agcaatctac aagctctctt aaccaaaacc ttacctgagg ttttgtcttt 1716181 actgctctgc atttatttct ttcggtatcc gagaaggagc tttggggatt tttctcaatc 1716241 tgctgttaat cacatcagaa gagtatagcg taataatcat acttccccca tacctttttg 1716301 cccgaattaa gattggttgg ttatattggt tttgaaagcg aaagtcagga cctccccagc 1716361 ttaccgtcgc atcccgtccg ggcggtacat atggtacact tctagtatga gaatagcgct 1716421 gaacgatctg cagtcctgca cgatctactg cattaaatag agttgaggac acctgacaaa 1716481 ttcctcctcc tacaccttca gacaactccc cttttacaat aatgggtgca cttttatatc 1716541 ctttgttccg agttctcatt cccacaactt ggttaaacga aaacgtctca ttagggaaaa 1716601 caacgtgatt gtcgattgct tttgcagaaa gagaaatatt gtgtgaacgg cttttattgc 1716661 ttgagttaaa atacgtcacg tactgaccaa gctgctgcgt actgatgtga gctagcagct 1716721 cgctgtcaac tttcggataa atgttcattt ccggcacttc tatcttggag ggaccttgcc 1716781 cataaaaata cgcataaaac ttttccataa acgcctgttg atacagtttg tagccaaccc 1716841 tgcccgggac gatgcttcca tgatcgttaa ggacagcatt tatcggctca cggtacactt 1716901 tctgatcaag ctgtttgatg aatttactgt atttttcata gtcaaccatt ggagtgccgg 1716961 gaagaggcat tgtaaagtct tcacggttaa cagtggcaat cgtccgtcct tgctgtgtga 1717021 ccgttaaact gtcctgcggc tcactcggct gagccaataa aaaaagacca gtgatcaaaa 1717081 tttgtatcat aagtcggttt acctcccaat cattagtatg aacagccgct tatcctttga 1717141 tgtatttctt cccatcgttt gtttgaatct ttagacgttg ataaaaacct tcataaaaga 1717201 gcttagcttt atgttcacac cgatccctga gctcactgag gcacacggtt cattcagtcg 1717261 gcaagtttga agtagttcag catctcccag tgatgaggga tgcttttttg tcttgtcaaa 1717321 aatgaaaagg gtctcctata acaacaaaaa atcaatccat ttcaatattt ttttattgag 1717381 aaacgataaa ttttttgtta cattcaatta gacaacaaat aaatgaggtg cttgttatga 1717441 atcgaatgtc gacaattttt ttaaagatag ctttggttct tattggaatt ccaattcttg 1717501 ctttatgcat ttttttagtg cctaaggtag ccaactattc agcagaatta tttccaaata 1717561 tcgcttatat aaaatatctc gttttcatct atttgtatgt aacggcgata cctttttact 1717621 ttgctcttta tcaagcgttc aaacttttaa gctatattga caaaaacaaa gctttctcgg 1717681 gtttgtctgt aagagctttg aagaatataa aatattgcgc agtcactatc agtatctttt 1717741 acgcagcagg catgcctgtc ttttatctga tggccgagat agacgacgcc ccgggtatca 1717801 ttgtgatcgg attggttatt atttttgctt caatggtgat tgcggtcttt gctgctgttc 1717861 ttcaaaaact gttaaaagaa gcgattgata taaaatcaga aaatgactta acggtctgag 1717921 gtgatgacat ggcgattatt atcaacattg atgtgatgct tgctaagagg aaaatgagcg 1717981 taacagagct ttcagagaga gttggcatca ccatggctaa tctttcgata ttaaaaaacg 1718041 gaaaagcaaa ggctattcga ttatcaactt tagaagcgat ttgcaaggct ttagaatgtc 1718101 agcccgggga tatattggaa taccgaagtg atgaagacac aggattcgta aagaaaaaat 1718161 atgaaggatc aacagaaaaa taaagtgatt ggcggtgagc ttatggacat aaacttatat 1718221 ccatctagct gctatactaa gcgtcccttt catacacgaa gaacacaact atggaggagg 1718281 catacatcat gagagccata aaacaaatcg tccattttgg ctgggaacaa gccctttcat 1718341 gtttgtttcc tgccgttatt tttgcctctt tggctattac gcaaatcatc ccactgccct 1718401 tcttgccgcg gtatgactgg ctgctcatta tctgcgttct catgcaattg tggatggtgc 1718461 gttccggtct tgagacacgg gatgaattaa aagtgatcac attattccac cttattgggc 1718521 ttgctctgga actttttaaa gtccatatgg gctcctggtc ttatccagaa gaaggatact 1718581 ccaaaatatt tggagtacct ttgtatagcg gctttatgta cgcaagtgta gccagttatt 1718641 tgtgccaggc atggagaagg cttaaggttg aactggttaa gtggccgtct ttttttgcag 1718701 ttgttccgct tgccgcagcg atttatttga attttttcac ccaccatttt tctatagaca 1718761 ttcgatggtg gttatcaggg cttgtcatca ttgtcttttg gcaaacatgg gttacatacg 1718821 aggtgaatgg agctcgttac cgtatgccgc tcgcactttc ttttatactc atcggatttt 1718881 ttatatggat agcggaaaat atcgctacgt tttttggagc ttggaaatat ccaaaccaaa 1718941 tcgatacatg gagtctcgta caccttggaa aggtaagttc atggctcttg ctagtgattg 1719001 ttagctttct tatagtagca tcattaaaac aagttaagga gcagagtccc acaaaggcag 1719061 agatggatga atctttttct tagcatacgc atacaagctc ccaaatagag tgaaaagcaa 1719121 cgttcaaatg gttgcttttt tcttttatgt aactctgccg gtgagtattc atcttcttca 1719181 aatttcatcg caacacgata actgattcag attacaactg ctttcaacac tttgacaaac 1719241 tcatgcgccg ccggcgttat ctcttcaaat gaatgtgcga tgacgccaat atcgcgtgtg 1719301 accctaggaa agatgtcctt tttaatcaat tgatgcggga cggatgaaag tgtaaagttt 1719361 gaaatgatgc cgatacccaa gttatttttg accatattaa tcaaggtttc ggcattttgc 1719421 acagttaagt tttcctttaa ttcgatgttg tattgcgaaa atgcgtttga catcgcgatt 1719481 tcatgaccgc ctttacaaaa aatgaggtca tcttgatatg tttcaaggtc gacatgcttt 1719541 tcaagtttta attcgtcacg ctgcggcggg atgacggcca ccatatagtc gttacacaat 1719601 agctgatttt caaacggttc aaatggagat gctgcgatcc cgatatcaac cgtccgatct 1719661 tcaacccatc cttttatttg gtcagaggtt ccttcgatca attctatgcg gatcagcggg 1719721 tagtttgatc tgaatgccgc aatcgcctgt ggcatgatat ttgttgaaac tgcaggaaat 1719781 gaaccaattt tcaccttccc gtttaacagc ttgttttccc ggttggctac ttgatatatt 1719841 ttgctttcaa ttcccttcat ttgcctcgcc agcagcaata tttcttttcc gatgtcagtc 1719901 agcattaaac catgatgttt atccctgatc aataatttga gctgcagtga gctctccagg 1719961 ttttttatcg ctttacttac cgccggctga gagatgaaca attcttttgc cgcttctgta 1720021 atatttaatt tctccccaac ttttacaaat atgtgaagat ggttcatgtt cataaccatt 1720081 tggttatacc cccaataata aaaatgtatt tcagttatac ataaatgtaa catatgatag 1720141 aaaccagcac gatattttaa caagaaaggc ggcttcatta tggtaaaagt tatgctggga 1720201 atcatatctg tcacacttat ttggggttat acttgggttg cgatgaaagt aggaattcat 1720261 gacatccccc cgcttttatt ttcgggtttg cgcctgttca tcggagcagt tcctttattt 1720321 ctcattctct tcatccaaag aaaaaagctt tcaattcaaa aagaacatct caaaagctat 1720381 atcatcatga gcctgttgat ggggctgggc tatatgggga ttttgacgta tggaatgcag 1720441 tttgtcgatt cagggaaaac ctctgttttg gtatatacaa tgcctatatt tgttacggtg 1720501 atcagccatt tttcattaaa cgagaaaatg aatgtgtata aaacgatggg actggtctgc 1720561 ggcctcttcg gactgttatt tatatttgga aaggaaatgc tcaatatcga tcaaagcgct 1720621 ttatttgggg agctgtgcgt acttgtggca gcgcttagct ggggaatcgc gaatgtgttc 1720681 agcaagctac aattcaagca tatcgatatt attcacatga atgcctggca ccttatgatg 1720741 ggagccgtca tgttattggt gttttccttt atatttgagg cggtcccttc agccgagtgg 1720801 acatatcagg cggtgtggtc attgctgttt aatggcttgc tttccaccgg ctttaccttt 1720861 gtcgtatggt tttgggtgct caatcaaatc caagcgtcaa aagcatccat ggcattaatg 1720921 tttgttcccg tattggccct attctttgga tggctgcaat tgcacgaaca gatcaccatc 1720981 aatattatcc tcggcgcact gctgatatgc tgcgggattt ttatgaatac atttacattt 1721041 tcacgacgga aagtgtgaat gatatacatt tcccctgtca tttgggcttc atgtgacagg 1721101 agaagactat tacgagaaag tcttctagaa tcctgacgac agcctattaa acaatgaaaa 1721161 aagctaatgt ctgcatgtag acattagctt ggctggcgtt taggctggtg agaatccaga 1721221 tactttttta ttaccattct ggctgatcaa actgaaaacc gtatagacct tttactttaa 1721281 catctccgca atctggatct tttgtcaaaa tcaaataatg agtcttataa ggcatcgtct 1721341 caactcgatc agttgcacta aaatcaaaat gatcccccga gaagtttttt tcactaacgg 1721401 ttatttcata tcctgacaaa gtcattcgca tgattcttgc gttaattgta catccttcag 1721461 tatcgaaaat ggtgaatctg tacccaaagt gagatgtcca atggtttgaa tttaggtcat 1721521 cagacttcat aaaccatttt tcattctctg tcattgtaaa actcactttc tcctcatctt 1721581 tcacgataac ggccgaagct tcccctacat ggatagtcaa agccaaaaga aatgtaaaag 1721641 ctaacatcaa catctttttc aaaagagttc ctcccgatat cttttacttc aatatattgg 1721701 aagggtcttt tctgatcaag acagtcttct ccaaatgaat ctttagcacc atgaaatgag 1721761 ccttaataag aacagtttta acccaaatca acctctattc gaaataaggc ttaccaatct 1721821 atattctttt taaaagtttc tgcatttctt tatttagctc ctagacacat ataaaaaatg 1721881 ctcctataag ttcaggagca ctacaaaaaa ctgctaaagt gttttctatc gatttattgt 1721941 attcattagc tcaaagaaat attcaggctt ttgagtctta tttagcttat accatgaacg 1722001 caatgtatct ggtgcaaata catctaattt tttcaatact tctaccgcaa attccagagg 1722061 agcaattcct gatgcagtaa ccaaattttc atcagatact gcaggcccct tttcatagaa 1722121 tgtttctcct ttgtaattag ggcagaccat attcatatag tcgaggtcat tgcttgtgtg 1722181 ctttctcgaa tttaagtatc cttcattcgc gaggcccaag gttgccccac aaattgcagc 1722241 aatagtcgtg ccgagcttta aagcgtcgcc aacttttttc aagatcggct gatgaatatc 1722301 ttctccccaa gtgtttcctc cgggtaaaat gataagatct tgactcccaa gagtacattc 1722361 gtcaagagaa atatctggtt ttatgcttaa tcctcccaac gtagttatca tttctttatt 1722421 aacccctact gtaactactt ttaaagatgc tgcatcttgt ttaaagtatc tccctgagtt 1722481 tagttccgca attaaatatc catattccca gtctgacatt gtgtgaaata cgtagagata 1722541 aacttttctc gtttgcatcc aataacactc caatcacaat tgataaagct ttctaataga 1722601 tgactttgct gacagtcatt gtcagctttt ttgttgattc tattcttatg cccttgttct 1722661 cccaacttat aaaaatataa gatcaattga ttctatgttt actagcgcaa aggggtttgt 1722721 tacactaact gtcatgggaa acatttcaaa ggtaatacaa aatcatttga atgaggaggc 1722781 ctgatgaagt tgaaaactaa agcgtcaata aaattcggaa tatgtgttgg gcttttatgt 1722841 ttaagcatta ctggtttcac accttttttc aactcaacac atgccgaagc aaaatccata 1722901 gaagacacaa acatggcaag ctgtataacg aataaaaaat ttgttcaact tgagaaaaaa 1722961 tttgatgcca ggcttggtgt ttatgcaatt gatataggtt caaacaagac aatcgcctat 1723021 cggccgaatg aacgatttgc ttacgcatca acctataaag ttctagccgc agctgctgtc 1723081 ctgaagaaaa actcaattga aaaacttaat gaagtcatcc actacagcaa ggacgatctt 1723141 gttacatatt ctccaatcac agagaaacac ctagatacag gcatgagcct aaaagaaatc 1723201 tcggaagcgg ctatccgtta cagcgataat accgctggga acatcttgtt gcaacagctt 1723261 ggcggcccta aaggttttga aaagtcactg aaacagattg gggatcatgt aacgaaagct 1723321 aaacgattcg agacggatct aaactctgcg attcctggtg atattcgtga caccagcacc 1723381 gcaaaagcac tggcaaccga tcttaaagcc ttcactttag ataacactct cacgactgac 1723441 aaacgcatga tcttaaccga ttggatgcga ggcaatgcta ctggtgacga actgattcgg 1723501 gcaggcgctc caataggatg ggaagtcggc gataaatccg gagccggaag ttacgggaca 1723561 cgaaacgaca ttgctatcgt ttggccgcca aacagagctc ctattgttgt ggcaattctg 1723621 tcaaaccgct ttacgaaaga tgctaattat gataatgctc ttatcgctga ggctgcaaaa 1723681 gtcgtcctta acgatctcaa ataatatgtt tagccttttg ccacaaagga aaagacatta 1723741 cttttttaac ttctaccgtt cattttttga tgaacggttc tttcataaga cctctagaat 1723801 catatattta aacaccacaa aattaaacat tattataatt aacagcaagt tttcatttta 1723861 tggaacaagt aaagtttgaa tctgacaaga attaagacta agcaccctaa aatccgtttt 1723921 cttttcttcc aagaatatac tccttagtgc aagccattat aaagatacaa gtgaacatac 1723981 aatgcagaca actctcttaa gtctcttatt ctgtgaccaa tttgtaatac tcatgaatat 1724041 ccggactcac ttccaatatt tcgtctcgtt cgaagacact aacatatcaa accacttgaa 1724101 ttaacataac tgaacttgat attggtcact ggcagtttca atgcaataga acaacatttg 1724161 ttgtctcaga ggttatctat atgagaattc aacaattttt ttataataat tcatattttt 1724221 gtatcgttgc acttggtgga tttgactctt ttcgtgtatg gaaccacact tttatttttt 1724281 cacctctttt gagatcatct gtgttatcaa tctcacttaa tcctacaatt actatgttat 1724341 ttttaaactt gttcataagt tgtccttcag aaagattgta atcttctttt cctggagctt 1724401 ttgtatcggt aatgagaatt gccctttcat tgtctttaag cacgacatag cctactaggc 1724461 tctgcatctt tgtttcgtct ccgttttgtt catttttatt gcagcctgca aggaaaataa 1724521 tgagcataat gagcactatc aagcttactc cgattttagg catctttctt cctcctcttt 1724581 aaactcatct ttaaaataaa caacaggata tcacccaacc catctacttc tttttgcaat 1724641 tcataacagc agcatactca ttctccaatt cctcaacctt ctttttattc tttctcaaat 1724701 atttgcatgt ggtagccctc gatattatcc gcttactcat ttttgcgctt tcaaatatat 1724761 tattgaaggc cgcttctttc tggattccag cataaatata cttatcctta ctgtcgttta 1724821 ctatcgcaac ttccattaaa atcgagattt ttactttttt tatgatccat tattcacttc 1724881 caaaataact tccaattaca acataatata tgtataaatt gtaaatggag ttgatgtaat 1724941 tgaagattag gaaaatctta ttgagttctg ctttatcctt tggcatgcta atatccgcgg 1725001 ttcccgcatt ggctgctggc acttcgtctg aggttgcagt aaaaaatgaa gaatatgatt 1725061 atgacactat ataccgcatt agtcctctgc caatggactt ccagccaaca atagaataca 1725121 acggttatac ttatacgctt acacgtcatt attttgatta ctcaatcggg ttttacacgg 1725181 ctatttatac aaaagttgtt taaacttata aaggagcttt ttagctcctt tttctcttgt 1725241 tttaagcaag gtatttcttt ctatgtggtc ccctatcaaa tacaacatca acattctcca 1725301 gttctctttg acacgaacaa aatctaaagt ttggttttaa atgctggtaa taaaaaattc 1725361 actttaaaga agtgccgccc gcaaaatacg gcttttgtac actacgccaa ttttatattg 1725421 aaaagccaga cctcctcaaa gaggttccag cttttcttaa tgtgctatcg atcttcgtta 1725481 gttcaacggg aactttatca ttcggtacaa atgcagcctc ccaacttcta gttagggctg 1725541 atggcggaat atctgacggt tctctacaca catcagacat tagaagattt caatgtagcc 1725601 ttctgtacca tgaacgcgaa ttcgttgccc atcttttatc agcttggcag cattttcaac 1725661 gccaacaact gcaggtaagc catattcacg ggctataaca gctccatggg tcatcagccc 1725721 cccaacttcg gtgactaggc cttttatgga tacaaacaat ggtgtccagc ttggatcggt 1725781 aaaggaggta actaatatat ctccatcttc taaatccgca tcttccatgt ttaaaatgac 1725841 acgcgctcgc ccctctataa ctccggagga aacaggtaga cctacaatcg ctccggctgg 1725901 gagattttct cgtttatact cacctgtaac gatttcacca tcagacgtga taacacgtgg 1725961 tggagatagt ttttcatata atgtgtactc gtcttttcgt gtactgatga tttgataatc 1726021 cagtttatgt gtgcgcacga cttcgtgaag ttcttcaaaa gtgagatagt atatatcttc 1726081 tttttcatga ataacgcccg cttctatgag ttgttcggct tctttcagta aagcctgctt 1726141 ataaacgaag tatcgattaa ccatgccgta ttttggatat tccctaaacc cgctgaaatt 1726201 ccggatgata tctatcgctc gttttgtttc tttggctttt tgttcaccat ccggtaattg 1726261 cttcaatcga tctaataact cttgttcttt cttcaaagct tcctgtcgcc cttgctcaaa 1726321 tttccgatgg ccgacattag gctcaaaatt tttaatatta ttaagaatca ttgggacaag 1726381 tgtagttggt ttttcgctcc atcgagttct tgtgatatca atctctccgg tacatcgcat 1726441 tccgtatttg ctgagataat catagatcgc gtctcgggtt ttgcttccgc catcaaactt 1726501 agccagttca tccaaaaagt tatcatcttt tacatgttgt aagtaatcaa ttacctctgg 1726561 ataaggacga atcacatctg cgacgtctaa tagcgcaaga cccatttctg aagtaatatt 1726621 atggggtaca gattgagaaa gcgtatctgc tgcgtttttt tcacctaacc actcgttcat 1726681 tttttcgtta atccataatg aagcattcat agcagttcga attagaaccg aactttttgg 1726741 gttaaataaa atcttcttta attcctgaat atcttccaga ataaaacgaa ataaatctga 1726801 tcctgatttc gtttggatgt tttgttttaa ctcttctatc gatgtttgac tgctctcaat 1726861 caaatcagac acgattgtcg gatcgttttc aacttgagcc ggcatatctg cattgcctct 1726921 gctgggattt ggtgctgttt tatcatttgg tatcgacttt atgaaatctc gtcgctttat 1726981 tatggtcata agtgcgtctt ttaagagctg atcgtgctgc cccatgcctt ttaagaaaac 1727041 ttctctgctg tcaggggatg ccagatgatg tgtgacatca acaaatagcc ttccaccggc 1727101 tttacgcatg ggtgcaacag tcgtcaacag aaaaaaagac aatcccagtg gttttatggg 1727161 atccgtcatc atttgttgat gaccaacaga aatatagacg tgattttctt ggtcactcgc 1727221 ttcagggatg gggaataaag tagtgattgg acgactctgt acaatataaa aagtatcgcg 1727281 ggccaaacac cattcgatat cttgcggctg gccgaaatga gcttcgatct gtcttccaat 1727341 gcgtgccagc tgtaaaattt gttcatcagt cagtgtttga gccttttgct gatcagaatc 1727401 gatctgctgt gtttctgttc cgccttcttt tcgtccgtag atagccattt ttttagttgc 1727461 tattctctta tcgatgattt gcccatcctg tactttaaaa caatcggcag ataccaagcc 1727521 agaaaccagt gcttcaccaa gtccaaaacc ggcatcgatg gataacacct ttcggttgga 1727581 ggtaatcgga tcagcggtaa ataaaatccc cgaagcctga gggaaaacca tcctttgaac 1727641 gataacggat aaatagactt ggctgtggtc aaatccattt tgcatacggt aaataaccgc 1727701 gcgatccgta aatagggacg cccagcattt actgatatgc tgcaagattg catcgacgcc 1727761 ggtaatattt aaataggtgt cttgttgacc ggcaaaagaa gcatgtggta aatcctcagc 1727821 agtcgcacta gaacgcacgg cataggcatg ttcctcgcca aactgggaga gatattgagc 1727881 cactgctttc acaacatcgg aaggaatgtc tacttccata atgatttgcc gaatcttccg 1727941 gctgatgtta ccaatctgat ctcggtcctc aacttttagc atggtcaatt gatccaacaa 1728001 cacttgtaac gtttcgtttt gttcgatggc tttttgatat cctactgttg tgacacaaaa 1728061 tccttctggt acttgtatac cttgaatttt tgataattcc cctaaatgta acccttttcc 1728121 tccaacgagc gaaagctgtg ttttttcaat ttcatgtaaa ccgagaacca aagaactcat 1728181 tctacatctc cccttcaaaa aaaaatattg acaagagctt cctagcagga tataataaaa 1728241 ttataagatg gatatctata actttttaac tagaaagcgc acgtagtgtg attatatcac 1728301 cgtgtctgtt tttgtgcaat ataaaaagaa cctgggaaat ttcaccaggt tcttttctta 1728361 atttccatag ctagtcgcat taaaaaactt ggtttgagct gattcaatcc tctaaggaaa 1728421 tcctaaagtt gggttctttt tgaacttact tgctttgttc gtagagtccc cattcataaa 1728481 ttggactttt tgttcttaac agtcccacct ttaactagta taaagttatg aggatctggt 1728541 taactactag atatttttat tttgaataag gcttatgttt gataaagaag ggttatgtaa 1728601 aggtgtctgt tgtgagcaag cgctgactac aaaaaattga tagcattctc atttaaatac 1728661 cattctatta acctataggg aaagttttaa aaccagatgg agaataccct acctccagca 1728721 attccaaggc cgttcaccta gtagaaaaca acctttaacc attactaacg attttaataa 1728781 tcattgatta taaaacttct caaggaacga tcagcagccc gttagctacc cctgattaag 1728841 gatgatctgt taccacactg ttacgttaga acttccacta ctttgatatc cttctgtcgc 1728901 catgacttgg taagcccaat tactgcccag attcattcca tggctcttcc atgcgttcac 1728961 atgattgctg aaagtgattg tagcgttgct tccggttggt ctcttcgact ggcgaacact 1729021 ccagtactgc gtaaaagtag tgcgatcgcc atcaatggaa ggtgcgttat aacgtgtagt 1729081 tgtatatatg tcatatgtac ccccatcact ttttacagta cctttatacg ttccagtagg 1729141 tctataagta ccccatgaat ccactacata atattctatg agaggtgatc tcgtccaacc 1729201 atataaagtt aaatatccat tgccattcgg cgcccaaact ccggcattat agtttatcgt 1729261 cctaaatggc gaacctgtag tccaaccttt accaacaaca aaatttccgg tattagacca 1729321 attaacactg taattcccgc cagacccatt gacagcgttt actataccgc ccccatcagt 1729381 ccaattttgc cagtagtctg tgctagctgc agaggcggtt gccgaaaaca agctaatact 1729441 cattaaagct gccgataatc caactaagaa attcttttta aacttaaaca tatgttacct 1729501 cctataatat tttttccgac tttgaggtag cactcgtata catttaaaac attcttaatt 1729561 actaacgcca aagcttttga tcgtcccctt cagtataata ccacgaattc atgagcaaat 1729621 attaaaagta tttgtaattc aattacaaat acctagaaac acattataag tggtcttctt 1729681 ccaccatatc ctgatccgag ctcgatgtac atgcctttac ggcacacacg aatgtggcgt 1729741 gtggtgcatc gcctcaatac gcaaagacgt ttgccttagg caaacgtctt tttttgcgtt 1729801 atccgatttt tgtgccgttt gggacaggct gatccggctg caaaaggacg acgtcgccct 1729861 ggccgggtat gccgccgagg accaagactt ccgatttaaa tccggcgatc cggcggggcg 1729921 gaaagttcac gactgctatg acttgcttgt tgatgagacc ttccggcttg taacgcttcg 1729981 tgatttgtgc gctcgattgt tttatgccga tttcagtccc aaaatctatc acaagcttga 1730041 ttgccggtac tcttgcttca ggaaattctt ccgcttttac aattgttccc gttctgatat 1730101 ccaatttctc aaagtcatca ataactgcca tatcaataac tcctttttct cctattgtaa 1730161 aggagatata caatattctt ttaactaaag agccatcatt ttttatccga atataaggtg 1730221 tttcgataca ggcggggcgg cattcctgtg cttttcgtga accatcttgt aaaagaagaa 1730281 aggttttgaa agcccagcgc ctcgctcacg acggtaagag tttcatttct ctccatcagc 1730341 attctttttg cttcctcaag gcgaaggtcg gcaatatagt tctgcgggga cttccctgtc 1730401 tgttttttga accagcttga atagtaagct gggtgataat gctcgatttc tgccagcttc 1730461 ttaatcgtca gccgctcaaa taaatggctg tgaatgtatg caattgaggc atagctatgg 1730521 gattgaagct tttcttttat gtattgtact agcatatgaa gcgagttggc tgttccggcc 1730581 tttgcttcct ctgtcagcaa gtacctgatc gaagaccaga aaggatcgag ggcagcttca 1730641 attcctgatc ctgcacgata ctcatcaatt ttcattgcat gaagcggaac atccagtaca 1730701 agacattcat ttcttccgat agaacggaag cgatgctcgc actgcggcgg aatatataaa 1730761 aaatgatccg gatttaattt cacctggcgc ccctcagtct caagatcaat actcccttca 1730821 agcggaaaaa gaaattggct gtacgcgtgc ttatgtgaat gatatagccg tgtgtatgtc 1730881 cgtttttcgc aaattatctc ttgaagcgag tccattagca aaccccttcc tttggtcatc 1730941 ttttaatccg gtaatggtgt tccgatatag gcgaaaagcc gatttttcca tataaagaaa 1731001 ctgccgccag attttctttc atcacttgta aaaacatgcg ttccgctccg ttgttttttg 1731061 cccattcagt caacaccctg atcacttggg ttcctgcccc ttttcctctg tgctcctcag 1731121 ctacaacgat attactaagt ccgccataac catcaatgac agaaaccgtg ccaagcgctg 1731181 tcaggctttc tttgtcatac atcttgaaaa aagttttaca cggcggcatg cgttcgaata 1731241 tgtgtttgta acctttgtga cgctcgggtg aaaacccttc taattgaata aattcatcta 1731301 tccaaacaga tgatggctct tgttcccact tgtatgtaaa tcggctgttg tcatttgttc 1731361 ggctcataat tgaccggcac aacgctgtca tctggaagca ctcgtctacc ttttcataac 1731421 ggctgtctgc caatgcgtca tcaagccctt tcggtgatgc gttgctaata tgaaaacaaa 1731481 caggtaagcc taaactttga taaaaaagtt cggcctctag ctgaaaatcc ccttcaggca 1731541 tatccgcaga cgtccatacg ctatttgccc ttttggttac gccaaaattc gctctgagaa 1731601 gccatttccc tatgcttttt tgaaaataag ccggccatga agctgccgct aatcgttcaa 1731661 tcttgcgaat gtcatccatt gcataatgcc tctcccctat gtatactccc ttgatattat 1731721 acaatattca gaaatataag acatccattt atttgtttac ataatatttt tattgtttat 1731781 taataatcct gacaaaaatg tccgaattga aaatgacagg ctttctaaaa tgtcctcctc 1731841 acgttcaaat gcttcttttg cgattaaaac agtaaagcca tgcagcagac ttctgagccc 1731901 ccttgtcgca tgaatggcag tcttttcact tgcatagccg ttttcaatga gcagcttcgt 1731961 cacaagacag acaatttggt cagagacgat ttccgtccgt ttgtcgtgaa ccttaagaag 1732021 agccgcttca taatatccgg gattttcaat tgcaaaatca acatatgcat gagctaaaga 1732081 aagcatcgcg gaatctccct ttcgttcggt tacggagtcc gccatttgat caaaaagctt 1732141 tgtcagtcct ctgacagcaa gttctgctct gatcgcttgc agcccgttga tatggttata 1732201 caatgacggg gggcgaacat tcattttttt agaaagtgca gcaagtgaga caccatttac 1732261 cccttcctga tcggcaatct ctgctgcagc gtctacaatc attttttggg tcaaacctat 1732321 tctcggtgac atgctcatca tcctttcttt gctttttgga tcgcctgtct catccgctct 1732381 gaaggtgatc gcaggaattt tccatgtccg acagcgagac aggaaggcgc cttatcggcg 1732441 agcaattgtg cacttttgat ggcctcctcc ttattccatg tggcgaaagc gggaaaagga 1732501 aacgcccatt ttatctgacc tgatacagcg attcctccgc gcaactgaaa cgcatctcct 1732561 gctattaaag tgccgtttct tgtatcaaga aatgacatgc tgcccggtgt atggcccggt 1732621 gttggaatgg caagcagaga accaattgtt tcaccgcccg tcagcagttg gtgaggcttt 1732681 gtttgtatgt gtttcggaat acctcctttt ataggcgtct gcggctcatc ttgccgcaaa 1732741 gatgtgtcac cttggagcaa gaatgaatcc cgttccgaga tcatgacctt tgcatgcgga 1732801 aatgtttgtg ccaatgtatc cagtgatccg acatggtccc catgtgcatg agtcagtaaa 1732861 atatgctgaa gcggttttcc aagctgattc acagcttgaa taatcccttt atagctgcct 1732921 ggcagtgcgg catcaataag ggtgacttcg ttttcttcct ctactaaata gcaattaacc 1732981 ggaaacaatg ctggaaaaaa agtcagctgc caaaccgttt ggtactgagt aattctcatc 1733041 tttttattcc tcctaacaaa aactaatggt gttagtttta ttattaacta acaccattag 1733101 tttttcaaga gtttattatt tttttatcgc tacataaatg ttaacttgtg ctcgctgtgg 1733161 cactgcggca ttttgatcat acatctcaaa gtcacctgta aacgtgcgca gatgccgctt 1733221 atcccaagtc caaatttcct tccacgtttc aagcacaatc tcttcaatag gaccgattct 1733281 ggaagtgaaa acggcgtaag cggaagccgg caaatcaata ttttcatatg gtcccggaag 1733341 aatgtcgtcg tattcctgaa acgttccgac tgaaaacgta taaaacccat tcgtctcttg 1733401 ttcataattc gaatataagg caataatgct cttgtctttt tcagcctgtg ataaaagagc 1733461 gctcatatcc tgcttccata attgatccca cagtgccgga atcctccttt cttccgtcat 1733521 ttccagtgcg ttgcttgtcc gttgtgatag tccggcaaat cgtttcaggt ctaagtgtgt 1733581 tatatgtgaa aagcccatac gatctcctcc tttttttaag attatagaca aagaaacctg 1733641 acagcagtgt gtcaggtttc atatattttt tgcatgtgat gaatggtttc ttttacttta 1733701 tcccttatat gaagaggctg cagaacctca atatcctttc cgaactggag caaaaaaccg 1733761 atcagccatt gatcttctgg aagtgaaatc accgcctggc agatttcatc ttcctcacaa 1733821 cagtgaagga catcatatcc gaaccattca cctatacgct gacgtgctga cggctgaaca 1733881 agaataacca attcagttaa acggtccttt tggtaccaac tcttatccca tggcaaagtg 1733941 tccagctgaa tgtcttttct gataaatgtc tgatgtaaga tggccagatc tttcatccgg 1734001 ttcagtttaa aaaagcgaaa atcatttctt accaggcagt aggcatataa ataccagtgc 1734061 cccgccttgc aaaccaatgt ataaggttca gtttcccgaa gtagtgtttc cccgcttgcg 1734121 cttgtatatg taaaagatat cgttaacaac cgatcgatgg cagcgctgat tttctcgcgc 1734181 agcgtctttt gatcctcagt atggccccaa gccgtcatgt caataaacca tttttctgtt 1734241 tggtgcttaa atgcttgagt agattgctca ggtataaggt gtttgatttt ttgataggct 1734301 gtgctgtgag aaacgggttc atacatagat gaaacgcttt gcaaagcgga agcaattgca 1734361 aacaattcct cctccttcag ccactctctt tcaagccgat acgtttccat gatgccaatt 1734421 ccgcccccgg aaccctgtga ggtcacaatc ggaataccag ccctattgat cgtctcaata 1734481 tcacggtaaa ttgttctgac agatacttca aacagctcag caagctctgc agcctgcact 1734541 tgttttttgc tgatcaataa cacaaccatc gctaacaaac gttccagttt cattctgcgc 1734601 accttttctt cttgtatttt ccaacaaaac aatcataaca ttttgataaa gcttgggcat 1734661 atctattatg cggcggaata cacctcgcat atgctatgaa aacaggggtt tccccttctt 1734721 ttttgtgttc agtatttatt tcagctacta tttccgaccg gataagcata cacttctcaa 1734781 cggaggggat ttcacatcat gcatcttaca cttcagagcg tttatcctgc cataatcatc 1734841 atcttttttc tgtataaaaa aattaaaagg tccatcggat accagccgct gaagccccgc 1734901 tggctgttca cccgtatcat tcttttctcg ctgtttgctt ttggactttc aatcttcagc 1734961 gccattcacc cttttttata tggatatctc attttgggca ttcttggcgg atggctcctt 1735021 gtctttttcg ctaagaaaaa catctctttt gaaaaacgca gaggaaagat ctattttcgg 1735081 actcatattt gggtagaggt gattctctta actttatttc tatcaagatt tctgtatcga 1735141 gtgacggagc tttatcttac ctcacctgat ctaaaccgcc ttggatcata cagtcagtca 1735201 atcggaacgg accctctgac aattggcgtc tgttttctga tagccgttta ttatatcggt 1735261 ttttcttctt ttatcatcaa gctcagcaga aacgaacttg aacagcacga atacaataaa 1735321 gaaaaagaca tccttgcccg ctaacagcga gttaagcaag gatgtctttt tcaatcatgc 1735381 tgtgtatgat ggatcatttg ctgaagaaca tctaaaacat gttcatcctc cggagagtaa 1735441 taaatcgatg ttccttctct gcgcgatttg acaagccgga gattttttaa aaatctaagc 1735501 tggtgggaca cagtggattg cagtaaattc agcttttctg caattccgtt tactgcatgc 1735561 tcaccttggg acaataaatg gagaattctg attcgggtag gatctgaaag cgctttgaat 1735621 gtttgcgcga ctagaaacag cgtctcctcg tccagatcag cagccgattg ttccgtttct 1735681 ctaaattcag tcatatgtat cacctttctt tattcatagt tttatcttat aacaaatgcg 1735741 cttgagtgca aaccagcctg cttgtattcc atttcaatct catagtttaa atttatgttt 1735801 caaatcaggt ttttacttgg tctgatatac cctcttatgt cataataaaa aaggtcatac 1735861 tgctccaaac attgagggtg aaacacagtg aagaaaaaga gaaaaggctg tttcgctgct 1735921 gcgggtttta tgatgatttt tgtctttgtc atcgcctctt ttttattggt cctgcttttt 1735981 ttcaaccggg atttaatcaa aaaacttccg atcgatacga aaacgattgt tttggaacgt 1736041 ttaaccgatt acaaaccctt ggtggaagaa gagcttgaaa gccaaggact ctctaattat 1736101 acatcactca tattaggcat gatgtatcag gagtcaaaag gaaaaggcaa tgatcccatg 1736161 cagtcctctg aatctctggg gttaaaacgc aatgagataa cagaccctca actcagtgtt 1736221 aaacaaggca tcaagcaatt taccctcatg tacaagaccg gtaaggaaaa aggcgtggat 1736281 ttggatacca ttattcaaag ctacaacatg ggggcaggtt acattgattt tgtagctgaa 1736341 catggaggaa cgcatactga ggaattggca aaacaatact ccgagcagca agtcaaaaaa 1736401 aatcctgatc tgtatacttg cgggggaaat gcgaaaaatt tccgctatcc gtattgctac 1736461 ggtgattata cgtatgcaga aaaagtaaaa gaaaaaacaa aaactgttga agaatctttg 1736521 caggttgcaa cacttgaaac catggaatcc aaggctcatg aataagagtc tatcaattta 1736581 ctgacaaaag cccaaaaatg aatttgggct tttgccatgt ttacacgtaa aaaaagccat 1736641 actgagtatg gcttttaata atacggtgaa atcatcaaat atacaataac gcctgtaagg 1736701 cttacataca gccatagagg cattgtccat ctcgcaattt ttttatggcg ctccacctgc 1736761 atgctgaagc ctctgatcag cgtaaacagc gcaagcggca caataattgc agaaaggcag 1736821 atatgtgtaa ttaaaataaa gaaataaatc gggcgcataa taccttctcc gccatagagc 1736881 gtgttttccg caatcgagtg gtacgtcaca tagcaaatca aaaatagtaa tgttgttgtg 1736941 aacgcagcca aaataaagcg tttgtgagct ttgatatttt tctgtttaat cataatcagc 1737001 gcggccaata agaagataaa cgtaaagcta ttgaatatcg cattcagcat tggcaaaatg 1737061 tgaatattcg catggctgaa ctgatctaat ttaggcataa aaaacagcac tgcgattaaa 1737121 ccgttaatca gaactgtcag cgtaaggaca atccccgtgt aatttttcgg tttattttct 1737181 gtttggttca tttggtgacc tctcctaatt tgtactggct atccaaatcg tatgcaaatt 1737241 caaagaagat gtcaacggtt tcgattgctt cgtcagaaat tagacacact tcaaaggccg 1737301 gaggctatta gccccggcct gttaggttta cgcctctttt atcaaatgtt caatgacctt 1737361 atgttcattt tcattcagca ggttcttttg aattttcgaa tgaatgggtt tattcatatg 1737421 ctgatccaag atatcggccg tttctttatc cccggcaata accattcgtt cccatctttt 1737481 cgcggcagct ttttgatcaa ggctggcagc cagccgctta tacagtctcg attggttctc 1737541 tgttacatgt tccctcatcc ggttctcttc aaatggtggc gctttgtcta cagcggaatg 1737601 gctattcttc caagactcat tgatcatatc atactcataa cgctccaccg cctcaatttt 1737661 tcctaaaaca gtttcaataa ttttcacttc atgctgctga gttaaaataa acgccgtact 1737721 tgggtatgtc tggcgcaaac cctttagctg atccaggaca gctgtttctt cccagtaaaa 1737781 tcttgtatct acagggactt gaagcttaat aggttcccat atgccgctgt cggaaacaaa 1737841 aaacacgaga ctgcggggca tgtcttttcc cattgcattc aagtattgat tcattttagc 1737901 cctgattcca tccagacact tttcctcctc tggatcacta gctgccaaat actcttttaa 1737961 tcggctgaat cctgacttta gggcaatctt ccattctccc ccctgctgct ctggatctct 1738021 catgtctgta ttgagataca gagagagaat tttatccggc ggttccaatt ggacatactg 1738081 taatttgtta atcaatgaat caatcgccat tccgattcct cctttttcac aggttagttt 1738141 tctttttcct ctcttaaaaa cgatcaaacc tgactttccg ctaatttcta gtaataatgg 1738201 aattgttgtt tacaatacgc ctctcttcta atacaattgg taactgtgtt tctaagctgt 1738261 tttttgaaag gagtttgatc ttgtttactg ttaaagaaaa aaatcgtcaa gagcttgagg 1738321 aagaactaaa tgatttagaa tttcaaattt atcgcatgca ggagaatatg aaggatttat 1738381 ctaaagatgc caaagtgctt ggtattgatc aatcgaaaca tgatgagtgg atgattgttt 1738441 cctcgattga tgatggccaa acatgcaaaa ttatgctaac tgattgtaaa acggcatacc 1738501 gaggaaaagg ctgtttttca cttgtagcgt cttacaagga cgatgccatt catatagggg 1738561 atataaaagg ccctccgaat cacgggtttg gctccatttg catgaaatat ttaaaagata 1738621 ttgcaagaga ccataatata ccgaaagtca ccggagacat cgccaaacgg gattggaatc 1738681 atgtagaccg gctgattcac ttttatgaaa aacatcactt caaagtatgt atcgatcatg 1738741 atacccaatc cggcagcatt aagtgggttg atttgtaaaa aagtctggaa gaaagagcca 1738801 agatatgctg taatggtata aaaccattga tggagggttc tatgtacgcc tcaaaactga 1738861 aaaagggaga cgaaatccgg atcgtgtctc ccgcgaccag catgtctata ttatcaaatg 1738921 aagcaaaaat ccaagcaaaa acggcgttag aacgcttagg ttatcgggta accatcgctg 1738981 aacacgcaaa tgaatgtaac gaatttgatt catcctctat cgagtcaaga gtccatgatc 1739041 tgcacgctgc cttttttgat ccaggcgtca aagcgatttt aacgacactc ggagggttta 1739101 attcaaatca gctgctgcgt tatcttgatt acgagaaaat caaacgacat ccaaaaattc 1739161 tgtgcggtta ttccgatata accgctcttt gcaacgctat ttatcaaaaa acgggtcttg 1739221 ttacgtattc aggtccccac ttctcaacat ttgcaatgaa aaaaggactc gattatacag 1739281 aggagtattt tctttcttgc tgcgcttcag acgatccgtt tgaaattcac ccctcaagtg 1739341 agtggagcga tgatcgctgg tttttggatc aagaaaacag gcgtttttat cctaataacg 1739401 gccctgttgt aatccaagaa ggttatgcgg aaggtacttt aattggcgga aacttatgca 1739461 cgcttaattt gctgcaggga acggagtatt ttcccgaaac agaacatact attttattga 1739521 ttgaagatga ttatatgtca gacatccata tgtttgaccg cgatctgcaa tcactcatcc 1739581 acctccccgc tttttcacat gtaaaggcga ttttgatcgg cagatttcag aaagcatcaa 1739641 acgtatcaat agatcttgta aaagccatga tcgaaacaaa aaaagaatta tccggcatcc 1739701 cgatcatcgc aaatataaat gccggacata cctcgccaat tgccacgttc cctataggag 1739761 gaacatgcag gattgaagct atttcgggta catcacgaat atggattgat aaacattaat 1739821 cagcttgtaa atttttttac aagctttttt agcgcaatcg gctatgcatg ccgcacgaga 1739881 catgacaaat gtcatatagg aggcatgatg tgtgctacta caaaagactt ctctcattag 1739941 cgtatactga accgagacac acaatgagag gatacttact atgactgaac aaaccattgc 1740001 acataaacaa aaacagctga caaagcaagt cgctgcattt gctcagcctg aaacaaaaaa 1740061 cagcctgatt cagcttttaa acacgtttat cccattcttc ggcctatggt ttcttgctta 1740121 tctcagcctc gatgtctcct atcttcttac gttagcatta acggtgattg ccgcaggttt 1740181 tctgacaaga atttttatca tcttccatga ctgctgccat caatcttttt tcaaacaaaa 1740241 acgctataac cacattctcg gttttctgac aggtgtcctg actttattcc cgtatcttca 1740301 atggcagcac agccattcga ttcatcatgc aactagcagc aatctggata aacgcggaac 1740361 aggagacatc tggatgttaa cagtaaacga atataaagct gcatccagac gaacaaagct 1740421 tgcatacaga ctttatagaa acccgtttat catgtttatt ctcggaccga tttatgtttt 1740481 tctgatcacg aaccgtttta acaaaaaagg cgcaagacgc aaggaacgtg taaacacata 1740541 ccttacgaat ctggcaattg tcgcgttggc tgccgcttgc tgtctgatct ttggctggca 1740601 atcgttttta ctggtgcaag gcccgatatt tctgatttca ggttcaatcg gtgtttggct 1740661 gttttatgtg cagcatacct ttgaagattc ttattttgaa gcggatgaaa actggagcta 1740721 cgttcaggct gctgttgaag gcagctcatt ttataaactc ccgaaactgc ttcaatggct 1740781 aacaggcaat attggttacc accacgttca tcatttgagt ccaaaggtgc ctaactataa 1740841 gcttgaagtt gctcatgaac atcacgaacc attaaaaaac gtaccgacaa tcaccttaaa 1740901 aacaagcctg caatcacttg cgttccgtct atgggatgaa gataacaaac agtttgtgtc 1740961 atttcgggct ataaaacata tacctgtaag ccttccgcct gattcaccag aaaaacagaa 1741021 gctgcggaag aatgcctgat gataaaggag gtcttctaat atactagaag gcttcctttt 1741081 tattgttgga gggtgcattc tggctttcac aatgataaag ttacaagtaa gatgaaaagc 1741141 tgaaaatgag gtaagatcat gattaaaaat cattttacat ttcaaaaact aaacgggatt 1741201 acgccctata tatggacgat atttttcatc ctccccttct actttatatg gaaatcatca 1741261 tctacatttg ttattattgt cggcatcatt ttgacgcttt tatttttttc ggtatatcga 1741321 tttgcttttg tctcaaaagg ctggaccatt tatttgtggg gatttttatt aattggcatt 1741381 tcaaccgcct ccattactct gttcagttat atttattttg ctttctttat tgcttatttt 1741441 attggaaaca ttaaggaacg cgtccctttt catattttat attatgtcca tttaataagc 1741501 gcggccgtcg cagccaattt cagtctcgta ttaaaaaagg aattctttct gacacaaatt 1741561 ccttttgtcg ttattaccct catcagcgca attttattgc ccttcagtat aaaaagccgc 1741621 aaggagcgcg aacgacttga agaaaagctc gaggatgcaa atgaacggat tgcagaactg 1741681 gtaaaattag aagaacgtca gcgaattgcc cgcgatctcc atgatacgct tgggcaaaag 1741741 ctttctctta ttggtttaaa aagcgactta gcaagaaaat tgatatacaa agatcccgaa 1741801 caagcagctc gtgaactgaa aagtgttcag caaacagcgc gaacttcttt aaatgaagta 1741861 agaaaaatcg tttcctctat gaagggcatc cggctcaagg atgaattgat caacatcaaa 1741921 caaattctcg aagcagctga cattatgttt atctatgaag aagagaaatg gcccgagaat 1741981 atctcattgc tgaatgaaaa cattttgagc atgtgcttaa aggaagctgt cacaaatgtc 1742041 gtcaaacaca gccaggctaa aacttgccga gttgacattc agcagctctg gaaggaagtt 1742101 gtgattacag tgtctgacga tggaacattc aaaggagaag aaaattcctt ttcaaaagga 1742161 catggcttac tcgggatgag agaacggctt gagtttgcaa acggaagcct tcacatcgat 1742221 accgaaaacg ggaccaagct taccatggca attcctaata attcaaaata aacataaagg 1742281 atggcttata tgattagtat atttattgca gaagatcagc aaatgctgct gggcgcttta 1742341 ggatcacttc taaacctcga agacgatatg gaagtcgtag gcaaaggtac aaccggccaa 1742401 gatgctgttg attttgtcaa aaaacgccag cctgatgtat gtattatgga cattgaaatg 1742461 cccggaaaaa cagggcttga agctgctgag gagctaaaag atacaggctg caaaattatc 1742521 atcttaacca ccttcgccag acccggttac tttcagagag ctattaaagc tggcgttaaa 1742581 ggctatttgt taaaagacag tccgagtgaa gagctggcca acgccatccg tagcgtcatg 1742641 aacggaaaac gcatctatgc acctgaactg atggaggact tatacagcga agctaaccct 1742701 cttacagata gagaaaaaga agtgctcgaa cttgtggctg acggtaaaaa cacaaaagaa 1742761 atcgctcagg aactcagcat caaaagcggg acggtgcgga attatatctc aatgattcta 1742821 gaaaagcttg aagtgaaaaa tcgaattgaa gccattaccc ggtcaaaaga aaaaggctgg 1742881 tttaaataaa aaaggatctt ggcatctgcc aggatccttt ttgttaacct gaaattcccg 1742941 tttgagaacc tcgtcgcaac cagaattaaa ttgatccata tcctcgctcc tacgcccgct 1743001 gaacgattgt ttggttaaca gcccaataaa agactggatt gaatgatatc cctgttaaaa 1743061 tggtcggcca ttgcacatca gcagaatttc tgatattgat tatattgtat tttcagtatg 1743121 acaaagttgt gccacttcgc tcccgaagct gccatgccca actgcaagag cctaatatca 1743181 caataaaaaa ccgtctgaaa tcaatccgat tccgtaaatg gtatctgcta catccaactg 1743241 cttattatct gccaaaaaca ccagctcgtt tcgctgatca aagatagtaa caaccagcta 1743301 taaatgtcat gatgccgaat gtctctgtaa tgtggaatca atcttttaac ccgagagccc 1743361 ctgaatcgca cataaagaaa aacgggacca ctttctttta tcagcatatg atataaacag 1743421 ctctaagcag aacaaaaaaa gacacaagcc aaaagcttat gtcttttatc acaatctata 1743481 ttattagttt aagactttaa cacttacagt tttgacgccc caattagaag catcactttt 1743541 acttggtaca aatacgtcga ttttatttcc tttaatagcg ccgccagtgt ctgctgctgt 1743601 tgcttccccg tagccttcaa catagacttt agaacctagc ggaattacat taggatcaac 1743661 cgcaataact ttcgcgttcg ggttcttatt taagtcaatg cctgtagctg taacgccgga 1743721 aatgccgccg tcgttagcag tgtaagcagt agcagtaact gttagttctt ttgaagcttc 1743781 ttgattattt gtatttgatt gaacagcctt ctcctctgtg ttaacagaag tttctgcctc 1743841 agcctttgtt tcttgtttag gttgctgttg tacagcttct tgtttaggtt gctctttttg 1743901 cacagcctct tgttttggcg cagcttgagg tgcgtttgtt tgcgcattct cagtagctgt 1743961 gtttgctgct gttgcctgac cttttactga aagagttgat ccagcataga tcatgtcaga 1744021 gcttaagtta ttccaaactt tcaggttgtt gactgtcgtg ccgaattttt gagcaatctt 1744081 agaaagcgta tctcccgctt taattgtata ttgcccagtc gtggttgttt cttctgaaga 1744141 aatggtcagt ttttctcctg caatgatttt atcagaagtt aacttgttcc attcttttaa 1744201 gtcctttagg ttcactccat ttttctgaga gattccccag agcgtatcac ccttttgcac 1744261 cgtaatttct tttgcagaag cgtgagctcc gaatgcagtt gttgaaagtg cagcaactgc 1744321 cacaaaggac ataatcgtct tcttcataag taaatcctcc cttgttagct ttttattggc 1744381 ggctaacagg tgatatcgta acacacgtaa atgtcaaatc aataacaaaa agatatgatt 1744441 tagattacag ttcctttaca tgaaggattt ctctctgatg gaaagacttg ctgaaccctt 1744501 gatataatag gcttcgcagg tctttttatt ttgaggcgaa acagagaaaa taaaatgtgt 1744561 tttttataga aaaaaagatt gtttttctgt ttttttagtc tgtcatcctt gcataagcct 1744621 gtatttcttg taaaaaaagc cggccgtatt ttgctctttt ttgttctccg actcctttta 1744681 tagacaaaag ttcatcatca tttacgggct gttttcctga catttctttt aacgtttggt 1744741 cagagaaaac aacaaatggc ggaacaccct gctcagccgc aatttctttc cgaaccatgc 1744801 gcaatcgttc aaatagctcg tcattttcag taatcgctgc cgcttttaac gcttcttttc 1744861 tcgctactga taattctcct ttcagcacat tccttccttt actgctgaca aaaagagtcg 1744921 gaaacgttcc gtctgacatc ctgatgaagt cgtcagaaat aagaaattcg ataaaatcac 1744981 tgatttcgcc aacggattgg tgttttaata tcccgtatgt tgaaaggtcg gaaaagccgt 1745041 tttcaagaac ttttttattt ttggagccgg caagcacctg ggcaaccatc gtcttgccaa 1745101 accgttcttt catgcgaatg atacaagata agaccatttg cgcctcccgc gtcacgtcat 1745161 gggccgctct tgtatcggta cagtttccgc actgtccgca cgcatcaggc tccttttctc 1745221 cgaaatacat aaggataaaa cgctgcagac aatcttccgt atgacagtag tcgaccattt 1745281 gtctcagctt ttttaaatcc tgcttttgtt tctcttcatg ttctgattgc tcaattaaga 1745341 agcgctgcac cataatatcc tgcggtgaaa acaggagaac acattcactg gcaagaccgt 1745401 cccgtccagc tcgtcctgcc tcttgataat agctttccat atctttcggg atttgtgcat 1745461 gcagaacaaa tctgatattt gatttatcaa tacccattcc aaaagcagag gttgccacca 1745521 tcacttgaag ctcatcatta agaaatcttt cctgctgctc ttttctcaca tcatcagcca 1745581 aacctccatg ataccggcct gccctgacct gatttcgttt caatctctca tatatccgat 1745641 cagcttcttt tctggtcgct gtatagacaa ttcctgcttc atgcctgttg ttttgcacat 1745701 attcgtctat aaaccgatct ttattttctc cttttactac tttaaaggtt aaattctctc 1745761 gggaaaatcc ggtatatacc gtgttttctt tttgaatatg cagctgtttg caaatatcat 1745821 catgaacctc gggtgtggct gttgctgtta acgccatgat gacaggcttg tcgtgtaatt 1745881 cacggaacaa gatttcaata ttcctgtagc ttggcctgaa atcatggccc cattgagaaa 1745941 tacaatgcgc ctcgtctatt gcgaccaaag gaacatctat gccctgcaaa atccggataa 1746001 actctatgga cgttagtcgc tctggtgtaa tgtaaaaaag cttataagcc ccttctttga 1746061 gtccgttcag cctctcatat atttcctgat tggattgtgt gctgttaatg taggcggcgt 1746121 taatccccgc ttcttctaac gcatcaactt gatccttcat caaggaaatc aacggtgaaa 1746181 tgacgatcgt cgtcccttca aacattaatg ccggaatctg atagcaaatc gatttgccgc 1746241 ctcccgtcgg cataatgcag gccgtatttt gcctcgcttc cgtcaccaag cggatcgctt 1746301 catcttggcc gctccgaaac ttctcataac caaaataatg agccagaagg gattgggctc 1746361 tatgtaacat aacgtgtaaa cctcgctttt ccttgaattt ctcccatcat atcataaaaa 1746421 agcggccttc atttctttca cacaaaaatg gaatattcac tataccaaac ctttttagat 1746481 aaaataaaaa gccatttccg aaaaggaaat ggctttcgct acgtcttgcc gtatgcaagt 1746541 aagaaagttt taaaccacca ctcctcaaag tgggtgtttg cagaaacgtt cctgtcgtcc 1746601 tctgcaatgg aggcatgaca ttccggcttc gatataaaac tccctattac agcttaaagg 1746661 ttaaaactta attaacaata cgcacaaagt agcttcttta atatagtaca ccatcaggcg 1746721 cttttaatca agaggtcaga acaattgttt agaaaaactt tttccagtga ataaaactgt 1746781 tttttctcca aaatacctga caattcgaca aacaaaaaat atattacaat aaaaaaaata 1746841 gcctttattg ctaaaagcga atgattattt tcttctatat taatgtgtat atacaaaaag 1746901 actcctattt gtaacgatag gagtcttggc tttattagaa ttttgcagca agatcttttg 1746961 cttcttgtaa acctttttca acgatttctt gcgcttgatc aggtgctgcg ttatgtcctt 1747021 cgatgacaac tgtgtgcaag tcttgaacac cccagaaacc aagaactgtt ttcatgaagt 1747081 ttaatgacat ttcaagtgca gccattggtc cttctgagta gacaccgccg cgagcgttaa 1747141 gaagcgcaac ttttttgccg cccattaaac cgactggtcc ttcttgtgtg tatttgaatg 1747201 taacgcctgc gcgagacaga taatcaacat aagtatgaag cactgctggc actgtgaagt 1747261 tccaaagcgg gaatgcgaaa acaactttgt cagcttttac aaactggttc agatatttgt 1747321 cagcaattgc tgcttgtttt ttctcatctt ctgtcatttc cattccttga cctgctttaa 1747381 atgttccgtt aatcatatct ctgccaaggt aaggaaggtt ttccttatga agatctaatt 1747441 caaccacttc atcattaggg ttgttttctt tataagcagc taagaaagct tcgtaaagtt 1747501 tagttgaaac gccttcttca gctgtacggt cgcttgattt tacaaataaa actgtagaca 1747561 tttgtattcc tcccggtaaa ctttttatat ttacttacaa atagtatgtt actttctttt 1747621 ttacgtaaag tcaatcactt tattttgaat atgagatttt ttttcaaaaa aaagcaagta 1747681 catctaatat cggtgtactt gcttggcatt tttacttcga atcttgttca cgatccaaga 1747741 tttcatacgt ctgcgagctt ttttgatcaa ttgtttcttt gttggataag tcttttacct 1747801 gttcatgaaa ctctctttca taagaaggag catctgtctc cagatcatcc tccacatcag 1747861 cttgggcctc aactgtcatt cttgcataag gaacagcttc aagtctttcg taaggaatct 1747921 cttggccggt tttttcacac acgccataag ttccgtcttt catcttttgt aatgcacggt 1747981 tgacctcctc taacagctcc cggtcaatct ctttcactgt ttggtctgtc atccggtctg 1748041 tgacgagcgt cccgtggtct gccatatggt tgtcaacccc attggaaagc tcccccactt 1748101 cttccgtcat tgattctgtt tcctttttct cgccagacaa ttctttttgc atatcgagca 1748161 atttatgata gagatgctgt gtttgttctt ttgtcagtgc catgtatatc ctctcctttc 1748221 tatcctgttt cccgttttgc cttctgtcaa acatggaaac atcgatggaa agatgagcta 1748281 ctgccttttt gaacggatcg tgaccgctgg cgtcgatggt gcttcgggtt ttcgttggca 1748341 ctttttgtcc ttctcttctg gcggtatata ataggttgcg cctatattta atctgccgct 1748401 cagttcatca atggtcagct cgccgaattc aagatgatag tcaacttttt cgacattcag 1748461 cgtttcaata tgtatatagg tttcttcaga ctcttgtttg ctgctttgtt tttgtttctc 1748521 aatcactgag agtctttctt cacattcacg cagtttgtca agttctggtt tcaagcaatg 1748581 cctgatcagc gaccggaaca tttttttcat gacatcacga ccctttgcat actcctcttt 1748641 cgtctacata tataatgagg tatatcccat agaaaggaga ggttttcatg cttccgacta 1748701 acatcaatat ttctcatctc aagactaact cgataggcac cggctcatcc cttacctttg 1748761 gttctgcgga gttaaggaac aggtgctctg ctatcaaaag aaataacggt tttggggaac 1748821 aaaatgcaga tggtattgtt atggtcattc cgattgaatc aattgatgac cgtgatgtgt 1748881 cagatgcact cagtatgaaa atcaatcatc aataacaatg gttttcgctt gaccttcgtc 1748941 tttttgaata gtgatgtata ggattccgtc tttaaaaatg gcattcatct ttccatgaag 1749001 atgatcggaa agcggaattt tcttttcaaa acttccgtat ttcccttctt tttggcgaaa 1749061 gtcctgttca ttaaaatagg aaaagcgctg ccccttcacc actaaataat ctccgtacga 1749121 taatatgtga acgtcttgtt tacggtagcc tggaagataa attaaaaact gcacttccgc 1749181 aacggtatct acaatatcca tgctcggaaa tgaagcatct cctttccctc gctgatcttg 1749241 ctgcgcaaac ggaaacggag attggccatt tgtcataaaa ggggtttttt ggtcttcatc 1749301 aaatacctgt ttccaaaagt caccgccgta catctgctgt gcgaattcca tccactgctt 1749361 catcttttcg aaatccattt gaagccccct gtcttaacat actttataac cgccagcata 1749421 caactataga aaggaggttt gcctgtggtt caaccaactc cgtatatcaa tattaatatt 1749481 ttcatgctga aaattaattc ctttgaaaat gcttcagcgg ttaacgtagg acaaaattta 1749541 ttggcagaat ggcaaaattc agataaaaaa aatcaaggct acggacagaa ttttggagat 1749601 gcgagcggat ttatgggcac gagaagccat gtggatgaca gagaccaaat tgattctccg 1749661 gcctcttttg aaagtgaagc ggttaactcc tcaatcaaaa ggaagtgatg agatgttctt 1749721 ttcaccctcc gtcgtaaatg tcggcggatt taaaatcaat acgatggatc gaggttcctc 1749781 tttaacactc ggtccgtatc agcaggtcga ttacttttta tcagctaaaa taaatcaagg 1749841 gtttggagaa gaaaatggcg actttactcc tcttgtcgtg ccgatttcaa atgtattaga 1749901 tgcagatctt gttgattcga actcagcgaa aaacagtgtg gtgtaataag aacagggcgc 1749961 acatgccctg ttcttgtttt tatatataaa aaaagcctaa ccattttttg aacggctggc 1750021 tcatcaaata ttcagctgca caaatgcttt gtcagcaccg cctgaacctc gcttaaatcg 1750081 gtgtctttcg caaattctaa ttcgaaagtt ttgcttcttg tcatcaataa aagcccagtg 1750141 tccggatcaa acattcccgc ttcttggatg gcaaagcttt caattgtttt atatggaaga 1750201 aatacacgaa ccttcttttt agaaaacatt ttattgtcaa agaaaatgat ccgcttattt 1750261 gtaaagcaaa tttggtccac tcggagctta taaatcgatt caattctttc cccttcaacg 1750321 agcaaagcct caagcttctt tgcgtccgtt gatctgctaa cagaaaaaat acccaatgaa 1750381 gaacccctct ttctgcattt atctatttgt tttatcattc actacataaa aataagtcct 1750441 ttatccctat ataagaatac gacatagaag acatttaaac cattacgaac agattacatt 1750501 tttcaaattt ttgatttgtt ttttggcttt taagctgttg tcatcaagta atacgcacat 1750561 atagagaaaa aagtttcaat attcagcaat gtttttataa aaaagtggtt tttaatgatt 1750621 tttttaattt tgttttatat ttcctgtttt aaccacaaaa aaaccgcagc tgagctgcgg 1750681 ttttatgtat cgactgcttt taacaaaatc tgtttgatgc ttcaaggaag cattacatct 1750741 cttcgaagta ttctttataa tagccgccga ctttattcgt attgtcgacc acaaagagaa 1750801 actcctctgt ttcatttttt acttcatatt cttttcccgg cgttaaaacg cggtttacga 1750861 tatatttttt tgcgtttgtc tgcacacact ttactttttt aatggtttct ttttcaagcc 1750921 aatttttatg aatcatgatg aaatctcctt ttcttatcta taagcttatt gtagcttttt 1750981 tcttttgtaa attgcaatat cggttattca ttgattttgc cttgatttct attatagaat 1751041 gtttgtatac gcttacgttt gaagcaacta tcacagctta tttctgctat tcaatccagg 1751101 aatcaatgtg ctatcaccaa gaatctcaga acagaccata aaaaatgact ggaggtttgt 1751161 tacggatgag ttctttaacg atgcaagtga cgaaaaggct ggagacattt ttacagggaa 1751221 caaagaagct ttatattgac ggaaagtttg ttccgagtgc ctcaggggca acctttgaca 1751281 ctccaaaccc ggcgaccggc gaaaccttga tgacgctgta tgaagcccag gctgcggatg 1751341 tggacaaagc tgttaaagct gcccggaaag cctttgacca aggtgaatgg agaacaatgt 1751401 ctccagcttc gagaagcaga ctgatgtata agctggcaga cttaatggaa gagcataaaa 1751461 ctgagcttgc tcagcttgaa acacttgata atgggaaacc gatcaatgaa acgactaatg 1751521 gagatattcc gctggctatt gagcatatgc gctattacgc cggctggtgt acaaaaataa 1751581 caggacagac gattccggtt tccggcgctt attttaatta tacgcgtcat gagcctgtcg 1751641 gtgtcgtcgg ccagatcatt ccatggaatt tcccgctcct gatggcgatg tggaaaatgg 1751701 gcgcggcact tgcaacaggc tgtacaatcg tcctcaaacc ggctgaacaa acaccgcttt 1751761 cagctcttta tttggcagaa ttaattgacc aagccggttt ccctgccggt gtaatcaaca 1751821 tcatcccagg attcggtgaa gatgcgggag aagcgctgac gaaccacgaa gcggttgata 1751881 aaattgcctt taccggttcc actgaaatcg gaaagaaaat catgtccacc gcagcgaaaa 1751941 gcattaagcg tgtgacattg gagctgggcg gaaaatcgcc taatattctt ctgccggatg 1752001 cgaatttaaa aaaagccatc ccgggcgctt taaacggtgt gatgtttaac cagggccaag 1752061 tctgctgtgc gggctcacgt gtcttcattc ataaagacca atatgatgaa gttgttgatg 1752121 aaatggcatc ctatgctgag tcactccgcc aaggagcggg acttcataaa gatactcaaa 1752181 tcgggcctct cgtaagcaag gaacagcatg agcgcgttct ttcctatatt caaaaaggaa 1752241 aagatgaagg agcaaaagca gtgaccggcg gaagctgtcc ttttgaagca ggatattttg 1752301 tcgcaccgac tgtgtttgcg aatgttgaag acgaaatgac catcgcaaaa gaagaaattt 1752361 tcggacccgt gctgactgca attccgtacg aaacagtcga tgaagttatt gaacgggcaa 1752421 accattcaga atatgggctt gcagccggac tatggacaga gaacgtcaag caggctcact 1752481 atatcgcgga ccgacttcaa gccggaaccg tttgggtcaa ctgctataat gtgtttgacg 1752541 cggcgtctcc atttggcggt tataaacagt caggactcgg acgagaaatg ggatcatatg 1752601 ccttggataa ttacacagaa gtcaaaagtg tatgggtaaa ccttgaagac taacatgtat 1752661 gtttaaaaaa ctgctgcctg ccagcagttt ttttctttct gtaatggcag taaaagacgc 1752721 tgaatatata tgcttctgaa ggagttgagc gtgatgggca cacttcagga gaaagtgagg 1752781 cgttttcaaa agaaaaccat taccgagtta agagacaggc aaaatgctga tggttcatgg 1752841 acattttgct ttgaaggacc aatcatgaca aattcctttt ttattttgct ccttacctca 1752901 ctagatgaag gcgaaaatga aaaagaactg atatcatccc ttgcagccgg cattcatgca 1752961 aaacagcagc cagacggcac atttatcaac tatcccgatg aaacgcgcgg aaatctaacg 1753021 gctaccgtcc aaggatatgt cgggatgctg gcttcaggat gttttcacag aactgagccg 1753081 cacatgaaga aagctgaaca atttatcatc tcacatggcg gtttgagaca tgttcatttt 1753141 atgacaaaat ggatgcttgc cgcgaacggg ctttatcctt ggcctgcttt gtatttacca 1753201 ttatcactca tggcgctccc cccaacattg ccgattcatt tctatcagtt cagctcatat 1753261 gcccgtattc attttgctcc tatggctgta acactcaatc agcgatttgt ccttattaac 1753321 cgcaatattt catctcttca ccatctcgat ccgcacatga caaaaaatcc tttcacttgg 1753381 cttcggtctg atgctttcga agaaagagat ctcacgtcta ttttgttaca ttggaaacgc 1753441 gtttttcatg caccatttgc ttttcagcag ctgggcctac agacagctaa aacgtatatg 1753501 ctggaccgga ttgaaaaaga tggaacatta tacagctatg cgagcgcaac catatatatg 1753561 gtttacagcc ttctgtcact tggtgtgtca cgctattctc ctattatcag gagggcgatt 1753621 accggcatta aatcactggt gactaaatgc aacgggattc cttatctgga aaactctact 1753681 tcaactgttt gggatacagc tttaataagc tatgcccttc aaaaaaatgg tgtgaccgaa 1753741 acggatggct ctgttacaaa agcagccgac tttttgctag aacgccagca taccaaaata 1753801 gcagattggt ctgtcaaaaa tccaaattca gttcctggcg gctgggggtt ttcaaacatt 1753861 aatacaaata accctgactg tgacgacact acagccgttt taaaggcgat tccccgcaat 1753921 cattctcctg cagcatggga gcggggggta tcttggcttt tatcgatgca aaacaatgac 1753981 ggcggatttt ctgctttcga aaaaaatgtg aaccatccac tgatccgcct tctgccgctt 1754041 gaatccgccg aggacgctgc agttgaccct tcaaccgccg acctcaccgg acgtgtactg 1754101 cactttttag gcgagaaagt tggcttcaca gaaaaacatc aacatattca acgcgcagtg 1754161 aagtggcttt tcgaacatca ggaacaaaat gggtcttggt acggcagatg gggtgtttgc 1754221 tacatttacg gcacttgggc tgctcttact ggtatgcatg catgcggggt tgaccgaaag 1754281 catcccggta tacaaaaggc tctgcgttgg ctcaaatcca tacaaaatga tgacggaagc 1754341 tggggagaat cctgcaaaag cgccgaaatc aaaacatatg taccgcttca tagaggaacc 1754401 attgtacaaa cggcctgggc tttagacgct ttgctcacat atgaaaattc cgaacatccg 1754461 tctgttgtga aaggcatgca ataccttacc gacagcagtt cgcatagcgc cgatagcctc 1754521 gcgtatccag cagggatcgg attgccgaag caattttata ttcgctatca cagttatcca 1754581 tatgtattct ctttgctggc tgtcgggaag tatttagatt ctattgaaaa ggagacagca 1754641 aatgaaacgt gaatcttatc aagcggagat gttcaattgg tgtgaagccc tgaaagatca 1754701 gattcaaaag cgaggtcagc ttgaccagtt tgaagatcaa atcgacaaga tgattgaggc 1754761 tctggaagat gaccaaacaa cagaagaaga ttggtataaa caggccgctg ccctttatcg 1754821 ggatattaca gaatcagatg atacaagtga aagacgcgct tatgtcccta tagggaaaca 1754881 cgtgctgcca aagcttcctt acaaatactc cgccttagaa ccttatatat cacgcgatat 1754941 tatgatcctt catcatacaa aacatcatca aagctatgtc gatggcctga acaaagcaga 1755001 atcagagctt aaaaaagcga gagcgacaaa gaattatgac ttaatcactc attgggaaag 1755061 agagcttgcg ttccatggag caggccatta tttgcatagt attttttggt tttctatgca 1755121 tccaaacgga aaacggcgtc ctacaggggc attgttccaa atgatagacc tttcatttgg 1755181 aagctattcc gcttttaaag aacattttac ccaggcctct aaaaaagtgg aaggcgtcgg 1755241 ctgggccatt ctggtctggg cacctcgatc aggacggctg gagattttaa cggcagaaaa 1755301 acaccagctc tttagccaat gggatgtgat ccccctttta ccgcttgacg tatgggagca 1755361 tgcctactat ttgcaataca aaaatgaccg ggccagctat gtcgatcact ggtggaatgt 1755421 cgtggattgg cgcgaggctg aaaaacgttt tgagcaggca aaagaagtcg tttggaagct 1755481 ctattaaaaa aagccccctt tcctcggggg cttcgtgtgt taaaaaatac ctatcacatg 1755541 caaaaacacg atgatgatgg caacaggaga tagatatcga atgagcagca gccaaaccgc 1755601 aaaccacttt cgtttgagat tggaaccgct tttcagctcg tcaaacaaat cctgtttcgg 1755661 tatttttagc ggaacaaaaa tcgaaatcag taacgcacct aacggcatta aaatattgct 1755721 cacaagatag tcagccgcat caaaaataga cagatgaaat atagtgacgt cacttaagac 1755781 accgtatgat aatgcagacg gcacaccgac aataaaaata gcaataccgc ctaaccaagc 1755841 gaatcgtttt ctcttattga tatcgccttt cgacagtact gcgaccaaaa tttccagcat 1755901 tgaaaaagca gatgtcaatg cagcaaataa aaatagaagt aaaaatgcta ataaaaagat 1755961 aattccgaac ggcatttgat taaacacagt cggcagaacg ttaaataaca gaaccgggcc 1756021 ttggtctggc ttgaggccga atgaaaatac agctggaaaa atcgcaattc cggccattac 1756081 agcaacaagc atgttcataa cagttacaga tacagcggac tgtaccagat tttcctgttt 1756141 ctctaaataa gcgctatacg ttaccatgac agatacaccg acacttaata agaaaaagga 1756201 ttgtcccatt gcatataaaa tggtattggc atcaattgca gttaaatcag gcatgaggaa 1756261 aaatttgatt ccttccatcg cgccatcaag tgtaaccgaa cgcaccatta aaatgatgaa 1756321 taatagaaaa agcgccggca ttaatacttg gcttgctttt tcaattccgc tgcttacccc 1756381 ttttgcaaca actaaaattg ttaccaccat aaagagcagc tggcctccta cagccaaata 1756441 aggatttgaa atggtacttg caaatatcgt atcaaaacca gatgtttgcg ataaaccgcc 1756501 agtgaagcct tttataatat aaattaaaat ccatccgcct acgacactgt agaaagatag 1756561 aagaataaag cacgtcacca tgcctaaata accgatccaa tgccacttcg ttcctggagc 1756621 aagtgtttta taggactgaa cggcatcttt ctgtgttctt ctgcctatga tgaattcacc 1756681 taacaataaa ggcagtccga ttaaaaccgt aaataaaata aaaataagta aaaatgcgcc 1756741 tcctccgctg gttccggcaa catatgggaa tttccatatc gcaccaagcc cgatagctga 1756801 tcctgccgcg gctaaaataa agccgagctt cgaagaccat tgatttgctt ccttcaccgt 1756861 atcactccta tttgatctaa ccattataaa ggttcattgt aagaatatct tcctatatag 1756921 tcaagaacat tttaattagt ttacatcata tatctataga catctgccaa aaactaatat 1756981 tgaattattc agaaaattat ttataataag agaatgttat gaaatttgta agaatttctg 1757041 ctgaagttct tgataagtgt gttaggagtg tttttatgga catcattaga aaaataagcc 1757101 attttgcagg acaaaccttt ggcatatggg tcattgtttt tgcagtgctg ggattttctt 1757161 tcccatcttt atttacgtgg atcagttctt atattacgat ttttctcggc attatcatgt 1757221 ttgggatggg ccttacactg caagccgatg atttcaaaga gctggtcaga aagccttggc 1757281 aagttattat tggagtaata gctcagtata cgatcatgcc gctcgttgct ttcggcctcg 1757341 catttgggct tcatcttcca gctgaaatcg cagttggtgt tattcttgtc ggctgctgtc 1757401 ccgggggaac tgcatctaat gttatgacat tcttagcaaa aggaaatact gccctttctg 1757461 ttgcggttac gacaatttct accttattgg cacctgttgt aacaccgttg ttgattatgc 1757521 tgtttgccaa agaatggctt cctgtctcgc cggggtcttt gtttatctca atcttacagg 1757581 cggttttatt tccgatcatt gcaggtctga ttgtcaaaat gtttttcaga aaacaagtgg 1757641 caaaagccgt acatgccctt ccgcttgttt ctgtcattgg catcgttgcg attgtctcag 1757701 ctgtcgtcag cggcaatcgg gaaaatctgc ttcaatcggg gttgctcatt ttttcagttg 1757761 ttatcctgca taacggtatc ggttatttac tggggtttct ttgtgcaaag cttttaaaaa 1757821 tggattaccc gtctcaaaaa gcgattgcaa tcgaagtcgg catgcaaaac tccgggcttg 1757881 gggctgcact tgccacggct catttctcac cgctatctgc cgtaccaagc gcaatattca 1757941 gtgtgtggca taacctttca ggttctatgc ttgcaacata ttggtcaaaa aaagtgaaaa 1758001 agaagcaagc tggatccaaa agcagcaatc tatcacttta aatatgcatc aaaaagggta 1758061 catcacttta tcgtgatgta ccctttttta ttatccttct aataaaagct gttcaggatc 1758121 ttccagtaaa tttttgattg tcacgaggaa accaaccgct tctttaccgt ctacaattcg 1758181 gtgatcataa gataaagcga tatacatcat cggacggttt tcgaaacgct cttcatcaat 1758241 ggctacaggg cgcagctgaa tcttatgcat gcccagtata ccgacttgcg ggctgtttaa 1758301 aattggagtt gacatcaatg aaccgaaagt ccctccgttt gtaatcgtga aggagcctcc 1758361 ctgaagctcg ctaagggtta atttattgtt tcttgctttt ttcgcaagct cgccgatctc 1758421 tttttcgatt cctgcaaatg tcaggcgatc cgcatcccgt acaaccggaa cgacaagacc 1758481 ttcatcagca gcaacagcga ttccgatatc gtagaatttt ttaacgatca actcatcgcc 1758541 ttgaatttct gcattcaaca gcggatattt tttcaatgca gccacgaccg ctttcgtgaa 1758601 gaaagacata aagccgagct tcacttcatt ttgctcaaaa aattgatctt tgcggcgttt 1758661 tctgagattc atgacagccg tcatgtccac ttcattaaat gtagtcagca tcgctgatgt 1758721 ttgctgtacc tctacaaggc gttttgcaat cgtttgtctg cggcgtgaca ttttttgcac 1758781 ttcaacaggt ttgtcaaagc tttgctgtgc tttttgagcc tgaggctgct gcttttgctg 1758841 aggagccggt tttgatgccg gtttttcgta cgcttcgaca tcctgcttgc gcactcttcc 1758901 aagcggatct ccagttggaa cttgagacag gtcaattcct ttttctctcg caagcttacg 1758961 ggccgacgga gaagcgatcg ttcttgattt tgcttcagat tgtgcttcct cgctcacctc 1759021 ttgtgcagct ggttcagcct gtttctcttc ttttacgctt tccttgcttt ctgttttctc 1759081 tgtaggagca ggggcagaac tttcacccgc gccttctgaa atcgtaccga taatttctcc 1759141 gacctggacg gtatcacccg aatctttcaa tacctcttga agtacacccg attcttctgc 1759201 tgtcaattca acattcactt tatccgtttc tagttcaagc agatattcac cctgttctac 1759261 atagtcacca ggctgcttta accattgggc tattgttcct tctgagattg attctgctaa 1759321 ttcaggtacc ttaatttccg ccattttttc atttccccct tagtttttgc gagtcaagct 1759381 atcagataca atacgttcct gttctttttt atgaactgtc ggatctccct ctgcagggct 1759441 ggatcgtctt cttcgtccaa tatattgaac gcttactccc tctggtgcaa tctctgtcaa 1759501 atacgggctg atataacccc aagcccccat gttctgcggc tcttcctgca cccaaacgat 1759561 ttctttcagg ttcggaagtt ttgcaaataa ttctttgact ccttttgccg ggaatggata 1759621 cagctgttcg attctcgcaa tgtgaagcca ctctttaccg tcttctaact tattaaaatg 1759681 atcgctaatg tctatagaca ctttaccgct ggataataca agtctggtta ctttttcata 1759741 gtcatgagaa agtcccgact gttcataaac aggctggaag cggctttcgc tgagctcctg 1759801 cacttccgac accgtatttg ggttgcgaag aaggctcttc ggcgtcataa tgacgagcgg 1759861 tctgatttct tcacgaagca gcattttagc ctgtcttctt aaaatatgga aatactgtgc 1759921 cgcgcttgtc aggttggcaa ccgtccagtt gttttccgct gcaagctgca ggaatcgctc 1759981 aattcttccg cttgagtgct caggcccctg tccctcgtaa ccgtgcggga gcagcatgac 1760041 taatccggat ttttggcccc atttcgcgcg tccggcagaa ataaattggt caaaatacac 1760101 ttgagcagcg ttggcaaaat ctccgtactg tgcttcccac aaaacaagcg tttccggtga 1760161 atgcacgtta tagccgtatt caaaaccgag aaccgatcct tcagacagcg ggctgttatg 1760221 aacagcaaat gatgtgctgc agtcagataa gtgatgaagc ggcacaaatt ctttgcccgt 1760281 ctcactgtca tgaagcacaa ggtttctttg ggcgaacgtt ccgcgctcgg aatcctgtcc 1760341 tgttaaacga atcggtgttc cgtctttcaa aattgaagca aacgcgagtg attctgccaa 1760401 agaccattcc acttttctgt catcatcgaa cgccttggcg cgtctttcta aaatgcgctt 1760461 tagcttgccg aaaacattaa atgactccgg ccagttgatc aattcgccat tcagcttgcg 1760521 gagcacatca aaatcaatcg aagtgtccac atctgggaaa ccgtttgata caggctctgg 1760581 aagttcaatt tcacaagcag tgtgttcctt tttagacgga actttctgat atgcatcctc 1760641 aatgcgcttc gttaccgatt tttcgatgtt ttgaacgact tcctcggtaa ccacgccttc 1760701 ttttaccagc ttttcagcga aaatttgttt gacggtcgga tgctttctga cagcatcata 1760761 cagcattggc tgagtggttg acggttcatc catttcgttg tgtccatagc gtctgtaccc 1760821 gatcaaatca atcagaaaat ccttgttgaa tgtttttcgg tattcgaccg caaacttaac 1760881 agctgaaaga caagcttcag gatcgtccgc attcacgtga acaatcggaa tttcataacc 1760941 cttggccagg tcgctggcat attttgtcga tctggattca gcgctttctg ttgtgaatcc 1761001 gatcatgtta ttggcgataa tatgaatcgc accgcctact tgataccctt ttaaagagct 1761061 taaattcaat gtttcagcta caattccttc cccagggaat gcagcgtctc catggattaa 1761121 aatggccagc gattttgttt catcttgtac cgggtatccg ctttgtgttc gcgtttcctg 1761181 tgccgctctt gtgctgcctt caacaatcgg attgataaat tccaagtggc tcgggttgtt 1761241 cgctaacgta atgcgcgctg attttgtttc agcgtcttga agctcccgat tcgcccccaa 1761301 atggtatttg acatcccccg tccatccgta gctgattcca atggatccct cagacggtac 1761361 aagatctttg ttcggcgcat gctggaattc agagaagatg atttcatacg gtttgccgag 1761421 cacatgtgcc aagacattca ggcgtcccct gtgcgccatc ccgatgttga cacttgtcgt 1761481 gcctgatttg acagattgtg caataatgtc atcaagcact ggaacaagag cgtccagacc 1761541 ctcaatggaa aagcgcttct gcccgacgaa tgtgcggtgc aaaaactgct caaagccctc 1761601 tacttctgtc aatctttcca gcacagctga cagcttttca gctgagttct tctggaacag 1761661 ctcgccagat tcaatctttc ttgtcagcca ctcgcgctct ttgaagtcat gcacatggtc 1761721 aaattcaaaa gagatggttc ttttatacgt atttcgtaaa tactgaatgg cttctaaacc 1761781 gttcgaaatg tttttaggag cgtctttgca gatgacagac gcaggtattg cttttatttc 1761841 ctcttctgtt agcccgtaat cggataatgg aaaaagttcg ctctttttct catcctttct 1761901 gagcggattg acggaagcgt tcaaatggcc ataggttcgg atatcttctg caagtctgac 1761961 tgcggatgcg atcttttgaa tcagatcggc tgtaacacgt cccttttctt ttgttcccga 1762021 ggcctctttt atatcgcttg gcggagcacc gagctcgtcg aacatttcct tcaaatccgg 1762081 gtcaatgctg ttcggatcct gggtatactg atcgtaaagc tccagcgcat agccgaggtt 1762141 cggaccgtaa aaatcttccc aattcattcg ttgtttcata ctattttgaa acatttgaat 1762201 attaccccca acttaaataa tcaagtgatt gattcactat cttgaaataa ctttcgaacg 1762261 ctgtgtccaa aattatgtaa taaaaacgct tccaacgata ttttaccact gtttgcaatt 1762321 tgattctacc ttgattgttc acaaaatagt aaaaaacctt tataaaaaac aaaaaattta 1762381 atcattcgaa aaaacaaacg ccaaaaagca taggattaag ggctatccta tgcttttatg 1762441 aagcagtttt ttcagcagcg gatacaaaac atccggtagc tgatcaacat ccgggacaaa 1762501 tatactgaat tttccgtaca tatcctggat cgtcttcatt tgcgattctt ctatttctga 1762561 gttggagaga aaaacattta tcacttctat tcctcttttt cgggcttcga taaccgcctc 1762621 acttgtatca acgatcccat tttgttcgta gccaaatgcg gccggctctc catctgagaa 1762681 aacaattaag aacttttgcg cctcgctgcg atgcagcatt tttttcgtca tctgcctaat 1762741 tgcgtacccg tcacggttat cttcttctgg ctcaagctgc ataatggccg gtccagaatc 1762801 ttgtcttaat gatgattgga agggaataac cgtattgaaa tagtttggct ggcttttttc 1762861 ggttgcatca tttgtgtcct cccaaaaacc gacaatctga tgcggaaccg ctaccgattt 1762921 caacgcttcg tgaaacagca cgattcctcg ttttgtttcg tccattttgt cgaacatgct 1762981 ggcggaacaa tcgaccagca atgtaaaaac tgcgtcgatt tctgaagatg gttcttgctt 1763041 tttgtagaac aggcgcggat ttcgctcagt gaagtaacga agaagcttat tgttcagtct 1763101 cccggcatga aggtctgttc tcggcaatgt ttttttatgc tccagcgttt tttgaatcat 1763161 ttgtttcaaa cgcttttgat acgattcaat cgtttttgcc tgctgtttat aagaaagctc 1763221 ttcttcactg gttgccggct gcggttcttt ataaattgga aatgcatatt tattttcttt 1763281 gccgtcagcc atacccgctc cgttcggctg gtctttttgg gactccagcg cttccagctt 1763341 ggaatagtct ttccgtttcg tttgtctggc tgatccttga acagagccaa gggcctgatc 1763401 tccatcgtcg ccttcccttg aagcatcttt tcctaaatct gattttgcgc cgtgttcaat 1763461 atcaaattga aggaagcttt tagacggtgc ttctgtttcc cggtgccatg tcggcatttc 1763521 ttcttcatgg atatcctcat caccgtctga ttgttttgga agcgtgatgt catcactcag 1763581 cttcggcgct tttttctctt cttcaaataa cggctgttct gcagcttttg cgtaatcaag 1763641 ctcaggcaaa aagaagtagg tgttcaacat gtctttatcg agtacctctt caagtccgtc 1763701 catgaggtcc tcaacaattt tcagaacctg ccgtgtcgaa tctgcttcat acacacgcaa 1763761 gagctgctgc tcaataaacg ggcgcatcag atcgatatct tcacgcatgg atggaagggt 1763821 ctcgagcggc gattccgctg tgagcttgaa atagatcgcg caaaagagcg catcggtaaa 1763881 aatgcttcgt tccaaattta aggtcagctg ggttgagaaa tgttttctgt acatgtcttt 1763941 tcgcttcgca aatacatgtt tcgtacccgg gcgctcacgt ttgatgcatt cttcgatcct 1764001 aatgtcttca agcagcataa agagctgctt ggcaaaactt ttaaacgtaa gatggcgatg 1764061 gatatcattc aaaaagttcg caaactcatg cagcgagcta tatcttgttc cgactgaacg 1764121 caggtagacg tcgcttttca gacccgcttc catgtcctca gctgccctgt ctttccaaaa 1764181 gtggctcata tagattttct tttcaaatgg attgtaatag gactgaacgc catactccac 1764241 ttctaccgct tcactcttgg tgagtgtttt ggccaaatca gtcagcatca taaataaaaa 1764301 tgaatcaatc gtgctgtcgt taaatttgat aaatttcatc gcagccccct cattcaaaca 1764361 gagtttctgc aatatttcgg acagccgctt tttcccgatc atcatcaagc ttttctacaa 1764421 ttccccgctc aatggcacga cgcggcggaa tataagcagc taaatcacat gtatcgatta 1764481 aagctctgat ggatgccgct tcttcagaca cctgtccgtt attggcctga acgatcaagt 1764541 cagaggaaag cgtgataaat ctgtcaatca atttctcgtc tttcaaggct gactgagaca 1764601 tgagcacttg tttcagcagc tcgcctttaa tataaggcac atcaatgatg acaaaacggt 1764661 ttttcaacgc ttcattcaga ggaacagttc cgacatagcc ttcattgatg gctgcaatga 1764721 ctccgaaacc gcttttagcc cgtatgacct cgcctgtaaa cggatttgtc atcatttttc 1764781 tgtaatctaa tacaccgttt agaataggca gtgtttccgg cttcgccata ttgatttcat 1764841 ctatataaag aaaatggcct tccttcattg cctttgtaac aggtcctgaa acaaactcga 1764901 ttgttgcctg gccagattga ttttcaatcg ttttataacc gaccaatgcc tcagcgtcca 1764961 agtcgactga acagttgacg ctgtgcatcg gtttatgaaa atagctggac aatgtttctg 1765021 ccagctttgt ttttcctgaa cctgtaggcc ctttcagcag gacatttttc cccatggcta 1765081 atgcaataat ggcgtcaaat aaaatggctt catcctccgc ctcatagcct gatgttccta 1765141 taagcgattg aaactctggg gaaataggct gctctttata tgataaaagc ttttgttgta 1765201 tatcttccgg caatgttaag tgctgtagtt gagttgtcat agacagattc cctttcctat 1765261 tcatattcca ttaacgagta tactaaaaaa gcccctgtat gctcaataca aaagggcctg 1765321 gatgatatta ctgcttctcg ttatttccca aaagggctcc gcagacaata cgcgcaccgg 1765381 aattgccgct tgggtttgtc agataatcgt ccgcttgttc atgaataata aatgcacttc 1765441 cgtcctcgtc gagaatattt agtttacttc cttttttcag tgaagtgtca ggcgcattca 1765501 ttatgacatc tacctttcca tcagcaccga cttcaaggtt cggcagatct ccggcatgat 1765561 gccccatcgg attattaaag ccgtgttctt tgttcagtgg attaaaggga ccgcccgctg 1765621 attcaaaatc cggcctgaca caagaacctt tctcataaat atgaaaaccg agagaagcac 1765681 ctggacgcag gctgtttgcg gaaatatgaa tatcgaggcc ttcatcatct gattctttga 1765741 tctctataaa accgactgct ttcccttcac gattgaccag ctggacatga tgaccaaacg 1765801 ctgacgtttc aaccactttt ttttccggca cccggttagg agggtctgga ggtttttttt 1765861 gtccgcatcc ggcaactccc agtgccgtca gcatcatcaa cagcaagaga cggtgcatac 1765921 tgtctccccc ttgttttttc taacagtgtg gtcaatcatt gtctggtata aacaaaaaag 1765981 cctataaaag gctttttgtc atactcattt ttaaaaataa cttcttgcgc ccaagtaccg 1766041 ctgtttccaa tacgaattgc tgagattgga aatgtcgacg cccgatgagc ttgcatgaat 1766101 aaaatcaccg ccgcctagat aaatccccat gtgagacggg ccggatttat atgtggtaaa 1766161 gaagacaaag tctcctactg acggctggct gactttctgc atgacattcc aataccctgc 1766221 cgtactcaat cttgatatag atgatacatt attaatgagg taataaatga agccgctgca 1766281 atcaaaaccg gcaggcgtgt ttccgcccca tcggtaaggc actccgacat attttttcgc 1766341 ttccgttatc attctgtcaa tcttcgaacc tatttgaatg tttgaccctg agttatcttt 1766401 tggctttgtt ggctttgtcg gatttgaagg attagatttt gatgctcccg aaatagtcag 1766461 aacctgcccg atttgcaaca catccgatga taaattgttt ttatcacgga tgctttggac 1766521 agtgactccg agccgatttg caattttcca cagcgaatcg cctgctttta ccttgtacgt 1766581 cgttgttttt gagggattgg agtttgacgg ctttttggaa ccgctgtttc cgttcttagg 1766641 tgaactgctt ccttttattt tgagcacctg tttaggataa agtgtatctg atgttaagcc 1766701 atttaaggtt tttaattcgg ctacagtcat atttaagctg tttgcgattt tccacagtga 1766761 gtcaccaagc ttgaccgtat atgtactttt tgaagaacct gaagaattgg aaccgctgtt 1766821 tttctttgat ccatttgatc cgcttgaact gcttgtccct ttgatcttaa gcttttgccc 1766881 cggacgaatc aggtcactgc tcaggctgtt taagctttta agctcagaaa cactcatttt 1766941 atgattttta gcaatcatcc atagggaatc accatatgca actgtgtatg ttgatgtttt 1767001 gcttgaatta gatggggatg tcgtgctttt tttgctgctt tcaggaacct taagactttg 1767061 tccgacataa agcaccgttg atttcaattt gttttcggat ttcagagctg atattgtcgt 1767121 atcatactgg cgggaaagtt tccaaagaga gtcaccgctt tttactttta tcgtttttgc 1767181 ttccgcgggt gctgcggcca tcgacgaccc aacaactgca gaaacagcca agccggctac 1767241 aatcttcttt ttcattcatt caacctccta aactgttttt ttgcaaaaac agctagtatt 1767301 ttgtttccaa aaatggcaca caactgtttt atcgtcaatt tttcagcaag ttaaaccctt 1767361 ttcaaacatt tggcgcagca ttttcagcat cgttcgacct ttaaaccttc aaataaacat 1767421 ctaacatttt acataagcac gatatgtttt tcgaaagtct aaggaactat ttaagcgagg 1767481 gtaaaaatga tggttttcta ttgatgaacg aagcagtttc tcctcctttc ttgtctattt 1767541 ttctaatcaa ttctctatcg gcgtgtcaaa tcccttcctc tgcattctta tgaaatggca 1767601 aaaagcctgt tctttcgata agaacaggct tttacactat gcatttgctg attgagtttt 1767661 ttgttttaca gcttcaagaa tgctgtcggc tgctttttta gagccgcctg ccgctttcag 1767721 tgattgtcca atttcttttg ccttttcagc atacgaacga ttattcatta cttcttgtat 1767781 cgtctctttc agtaggcttt cagacaattc ttccttttta attacttttc ctgcgccgac 1767841 tttttctacc tgatctgcga caacaaattg gtcgcctccc atcggaatga caacgagcgg 1767901 ggtttcaaaa tacaaacctt cacttgtgct gttcattccg ccgtgggtca caaataagct 1767961 ggctcttttc aagatctcaa gctgagggac atacgggcgt acaatgaaat tctccggaat 1768021 gtcgtttaac tcacttgttt taatatgctt gccgatggaa agcacaactt taccgtcaaa 1768081 gtccttacac acttcaaggc attgattaaa aaactgcttt tgattattaa aaatggttcc 1768141 cattgaaata aacagcacgt tttcattgtc aatctgatca aatgggaaat cattgtttcc 1768201 ggctctttct gtaatggaag gaccgacaaa tacatatcgc tcgccaaatt gctcagccag 1768261 tggctgaaat ccccttgatg taaagacgat tgtcaagtca ccatcagcta aaaaaacatc 1768321 aaatggcttc ttgatctctg cttgaaaatc agcatttaac gtttctgcaa gctgctggta 1768381 tgattcataa tgaggcgaat cttcaagtga tcctttcatg tacgctccca tcatttcctt 1768441 cgcaaattcc tcattcatcg caaaggttgt acacaatgaa aatcttggca gcttcagcat 1768501 gttggcaatg actttacccg cgagaagatg gtgatcatat atgacataat catacgattc 1768561 atgtttgact tcctcataaa tatgagtcgc gatatcctta caggctttca aaaaagcgca 1768621 gagcatttct gtgaaatctc tttcttcatc gccggttgcg tttttcccga agtaatctcc 1768681 tctgaaatca tgatactcac gaaactctat atcaagagct gtgatttttt ctttatattc 1768741 cttcactgcg tagtacgtaa tgttttctcc ccgggatttc agctccttca tcacaccgat 1768801 agagggatta atatgccctt caccggggaa accgatcatt aatacattag ccatgcggca 1768861 gcacccttcc tttgagaatt tatgtaatat tttatacggt actataaatg cataaacagg 1768921 taaagtattt cacttaatta atattcatca tatataactt ttctaccagt ttatattccc 1768981 tgtcttcaag acaaaaagca ttcagcttga agcgaatgct ttaataaaga tgcgaattca 1769041 gtcattttgt ctcatgatag gattcttaat caggcccttt ttattatttt tacgttcttg 1769101 gtgaaattaa cggatataat acaccgtctt tggcaaacga catcttccct gtttcctctg 1769161 aaaccacgag caccagtgca tccgtatagc ccgacatacc aagagccgcc cggtgccggg 1769221 ttcccaaatg gatatccact tccttcgtcg tcagcgggag cacattggct gctgacacga 1769281 gtttgttttc cctcactaat aaagcgccgt catgaagagg gtttccggga aaaaagatgc 1769341 tttcaattaa tgaagagctg atctcggcgt gtagggaggt gcctttttga ataaaacgtt 1769401 caaccgggtc tgctctttca atcacaatta aagctccatg cttatgttcc gataaggctt 1769461 taatcgcctt ggccagctca ataaatgccg gcgtaaattc ctcaatgtat gattgcaaat 1769521 aaaaggagga tgcaatcccc tgcatgtcct gaaaaacgtg ccccaaatca tctaattcac 1769581 aaaggagaca ctggtctttt tcgtgaagcg ttttcaagat tagagatgca tcacctaata 1769641 tttgctctaa gtacacctgt attttcccct tgaacgcatt ttctgatatc tgctcatagc 1769701 gcatagcctt catctcctgt ttaaatttcc aacttttcac gaatgcttat cttattgatg 1769761 cacattctat tggtaaagga gggatgtaaa gaatggaaat cgaaagaatc attcagtata 1769821 tttgcacctt tttaggcgtg atttcgcttt cttttattta tgcccaaatg tttagaaaaa 1769881 cgaaaccgac aaaaaaagaa taggcccggc gttcattgct ttttatacat aaaatgttat 1769941 aatttctctc gttatgaaaa agaaacggag atcaatgtat gaaagaaact caaaacgccc 1770001 gggaaaaaat caaacagctc ttgcacattt taataccgat attcattacc caagcggggc 1770061 tttctctgat cacttttcta gatactgtga tgtcagggaa agtcagcccc gctgatttag 1770121 ctggtgtcgc cattggctca agcctttgga cccctgttta cacaggactt gcaggtatat 1770181 taatggcggt caccccgatt gtcgctcagt tattaggtgc agagaaaaaa cagaagattc 1770241 cctttactgt tttacaagct gtatacgtgg ccgcgcttct tagcatcgcc gttttagtga 1770301 ttggatatgc tgcagttgac cttattcttg gccgattgaa ccttgatatt cacgtgcatc 1770361 agattgctaa acacttttta ggctttttat cactgggaat tttcccttta tttgtttaca 1770421 ccgtgttgag atcattcatc gactcattag gaaaaacgag agtcaccatg atgattacac 1770481 tcagttctct tccaatcaat tttgtattga attatgtatt tatcttcggg aagttcggaa 1770541 tgccggcact tggaggtgta ggcgcgggac tggcatccgc gttaacttac tggtgtatat 1770601 gcatcatcag ttttttcatt attcataaaa acgcaccgtt ttctgaatac gggatttttc 1770661 ttaccatgta taagttctct tggaaagcat gcaaaaattt gctcaaaatc gggctgccta 1770721 ttgggttcgc cgtgtttttt gaaacgagca ttttcgcagc tgtcacgctt ctcatgagcc 1770781 attttcatac agtgaccatc gcgtcccacc aggcagccat gaattttgcg tctcttttat 1770841 atatgctgcc gcttagcgtg tccatggctc taacaattgt tgtcggattt gaagcgggtg 1770901 cagcccgttt taaggatgca cgctcatata gcttaatcgg catcatgatg gcgatcggct 1770961 tttctttgtt cactgccgcc tgtatccttt tattcagaga gcaaattgcg ggcatgtaca 1771021 cttctgaccc cgatgtgctc cggctgacac agcacttttt aatttatgcg ctattttttc 1771081 agctttccga tgctgttgcc gcaccgatcc agggagcact cagagggtac aaagatgtga 1771141 actatacgct tgcggccgct tttgtctctt actgggtcat tggccttccg gtcggttata 1771201 tggtcggtac gtttacaagc ctcggtgcat tcggctattg gattggatta atagcgggac 1771261 tcgccgccgg agcagttggg ctgtttttca ggctggcaaa actgcaaaaa cgttattcgc 1771321 aaaaacaaca catttaaaag aggtgatcaa tcatggcaaa aaacaaaaaa ttattcgagt 1771381 atctttccca gcatgcggaa accatcagtt caacatggta tgaaacaatc gaggagactg 1771441 atcccaattc catttatgcc tcaacagacc ctgttgtcat tcacaattta aagagccaga 1771501 atcttgcctt taactataaa ataaaccgta tttttataga tgatgaggac gtatacttgc 1771561 ctatactgaa agaatgggcc tttgaagtca cacaggatca agagcattta aaaactccta 1771621 tccactatat tattcgggag tttgtcagag tgagagattt atatgtttct tatgtgaaag 1771681 aatttgtcca tctcaatcag aatactgtga aaagcgaaga agccgaagac ctgtatcacg 1771741 cccttataaa agcgtttgat cttgtgattc atatttttat agaagaaatg tacaaaaaca 1771801 caagccttca gcttcaggcc caaaaagata tgattactga attgagcgct ccggtcatcg 1771861 tgctgtttca cagcgtcgga ctgctgcctt taatcggaga tattgataca gtccgcgcca 1771921 agctgattat ggaaaacaca ctgcatcaat gtgcgaaaaa aaaggtgaca caactgtata 1771981 ttgatttgtc aggagtagct gtgattgata cgatggttgc ccatcagctg ttcagtctga 1772041 ttgaggcgct tcgtttaatc ggtgtttctt caactttgtc tggaatccgt ccggaaatcg 1772101 cgcaaacagc ggttcagcta ggtttgtctt tcgaaggtat ttccttgaga tccactctcg 1772161 cttcagctat tgcatcggac ttaaaattaa aaaaggtata aggcttaagg ccttatacct 1772221 ttttgattaa tcattccatt gatacgtcca atatatttct tcttcaaacc atgttgccat 1772281 aacaggttca ttatttttca atttctcttc aagctctctg agcatgcctt ctgtttgtgt 1772341 gcggtgagct cttaacgcat tcattttaat atcagctact tctttgatat caagtacgac 1772401 atcagcttcg ccgagaacct cttctctgtt gcgggtaatg gccatgcaga ttgtacgcgg 1772461 acggtcttct ttctttttgc ggtataatgc acggataacc gcttccccgc atgcatcatg 1772521 gtcagggtgc acaccgtgtc cgggataaaa tgtgacaatt aaacttggtt ttacatcatc 1772581 tatgatctct tccatgatat cagctaaata ctcatcgtct tcaaattcga gcgttttgtc 1772641 acggagtcca agcatccgaa ggtcattgat atccatttct ttgcaagcgt tgatgagctc 1772701 ttgttttctt agcagcggca acgtttcccg attcgcgaaa aatggatcgc ccatatttct 1772761 gcccatttca cctaaagtgg cgcaggcata cgtaacggga atgtcttttt ttctgtttaa 1772821 ggcaatgagg cctgccactc catatgattc atcatcaggg tgaggcagga ttactagtac 1772881 atgttctttc attattattc acccttttct ttaaactgtg aacggttttt cgctgatttg 1772941 cagagaaata gccagtttac cgcccggcag gtgtcccgcc attaataaac ggttttcttc 1773001 atctaccgtg tattcagtca agccttcagc ataaatccag ccttcttctg ttttcaagcc 1773061 aacgcggtaa ggcccgttgc ctttgatttt tgcctgatga taagtgactt ttgcattgcg 1773121 aatatacgca acaaccgtca tgttcttttc atttaagtgc gctgaataag aacctgtggt 1773181 ggtttctaaa tggatatata cagggcggtc cgcatatcgt tctaaagatg cttgcacatc 1773241 ttcttttatg atcgctttca tgattgctcc cctctttctt cttttaaata ctctgcacgt 1773301 tctgtatgta atttgaccag ctgatatttc acagccggtt cgagctgtga attcacaatg 1773361 cgctgaatcg cggcaaaata tttttccagc atcggttttc ggagtcttgg atgtgttcgt 1773421 ttatccaaga gctcaagatc aatcgcctct gctaccgctt ctgcgtcatc atgtgcgaga 1773481 gatcggttat tccaaagtga agcataggct ttcactatct ctttatcatt gtccatcgtc 1773541 ttgctccttt atgtcttaca tacatgaaat gattatacat aatatatgca tcagctgaaa 1773601 agccaaaggc ctcaatggct ttttgacgcc cgtttccact tcacttgtga aaacgtaaac 1773661 aagagcagcg cagcccatat acagctgaat gtaaaagcct tcgagcttga aaatggctca 1773721 tggtaaacaa acagcccgat cagcagggta atggtcggcg caatatattg taagataccg 1773781 acttgataca gtggcagccg tttcgctcct tccgcaaaca ataagagcgg caaagccgta 1773841 aacacaccgg ccaaaaagag aagcagccac gtccctccgc tttctgcacc cgctggctga 1773901 acatgtccgc tgaacagcaa ataccccaat gcaatgggca taatcatgaa tgtttccagc 1773961 gttaaaccga tggcgctcgg caggcttgtt ctttttttgc ttaacccgta cagcccaaag 1774021 ctgaatgcga gcagaagcgc aacataagga atggagccgt attggaacgc cgagatgatg 1774081 acaccggctg ccgcaatcga aacggccact aattgcaggc gattcagttt ttcctttaaa 1774141 aataaaatcc caaggagcac tgatacaagc ggattaatgt aatagccaag actagcctca 1774201 agcaaaaagc catggttgac agcccatatg tatacaaacc agttgatcga aatcaggata 1774261 gaagcaagaa ataaagagag gatccctccg ttctttttca gagagcgcaa ctcctgccat 1774321 cctattttcc attgccgcaa gaaaaaaagt acgatacaca taaaaacaaa agaccatata 1774381 atacgatgag ccaaaatatc aagagccggc agctgttcga gaagcttcca atagagcgga 1774441 aacaggcccc acatgataaa tgaaacggct gtgtaaataa cgcctttttt tgtttctgca 1774501 tgttgcattg atatccctgc ctttctttag agcatcttat attatatcac gtgaaagatc 1774561 tggtgggcat atactatttt gtccgtgaag aaaggatgtg aagacaatgt ttgagtggaa 1774621 caagtacttt cctttccaca atcaattttc taaagaagca ttaaaaaaag ctgatccgaa 1774681 agaagttgaa acgtatgtca atcgtgtgat ggaaagtgtg ttcggcagtg attatgcggc 1774741 tcaatttcct ttccgcgatc ctctccccca aaaagaacat cccgccaaac ctgatgcaaa 1774801 acctgatgtc aaacctgata ttgatatatt cgaaacagca gaccatgtgt ttgtaaaggt 1774861 gccaatcagc gaagaatggc tggaacaagt gagaatcaaa cacacatctc acgaattatg 1774921 gttggaaaac ctcccaagag cagatcatcc gaaaaaagta aaccttcctt gtttagtcaa 1774981 acgcaaagga acaaaagccg tctataagga tggccttctg gaagtcatgt ttcaaaagca 1775041 gcaagactac aatatgtccg aggtagaaat catccgataa aaaacggcct gcaatcgatg 1775101 caggccgttt tttattaata gaagccggga tatcccccgt atggcacgcc ggcaccaaaa 1775161 ccgtacggtc cgcctccata tccataaggg ccaggaggat aggcataggg acgagaatag 1775221 ttaaacagcg cactcccgag aaaaccgcct aataaaccgc cgactagagg agcgccaaac 1775281 aaaaaaggac tacgcgccgg atatccggct ggacctggga ttccgcgtaa atacgaatga 1775341 tgagggtaca tgattttttc ctcctttatg tctgcctata cgtaaagtat tcagcaagga 1775401 agaaaaacga ttgggctacg gactgtctat gattgttaca tcacaagccc tgccaataac 1775461 acacagccga gccctgtaac cgaaagaact gttgtaagca gcgtccaggt ttgaaatgtt 1775521 tctttcatgc tcaagccgaa aaattccttt accatccaaa atcctgcatc atttacatga 1775581 cacgcaatga cactgccggc tcctgttgca agcaccatta acgcagggtt tacactgcca 1775641 gcctccataa gcggagctgc cattcccgct gtggtaagcg cagccacggt agcagagcct 1775701 agacacagac gcagaaccgc ggcgatggtc catgcaacga atagcggcga catgtttgtt 1775761 tgacggaaaa aatcagcgac ataatcgccg actccgccgt caatcagcac ctgtttaaac 1775821 gctcctcccc ctcctatgat gagcagcatc atcgcaattt gcgaaattga ttctgaaata 1775881 gatctgccga tttcctgcat agatatttta cgggcatatc ccatcgtata gagtgcaagc 1775941 aacagcgaaa tgagcattgc cgttcccgga gtgccgataa attctataat gtcttttcct 1776001 tttgaatgtt cactcaataa taaagaaaaa attgttgcca ttgccataaa gataaccggg 1776061 aataaagacg tgacagcact gatcgcaaag cccggtgttt catccagctg aaattctttc 1776121 cttggtccta accccgatag gtttccatgc ttttgatacg caccaggaaa ccgtttcatc 1776181 gcaaatttat taaataaagg cccggcaatc acagttgtcg gaacagcgat gatgattcca 1776241 aaaagcagca cctggccaat atgggcacca tatgcaactg agatagcagt tggagcagga 1776301 tgcgggggca aaaatccgtg agtaacattt aaggcggcgg ccatcgggat tcccagatac 1776361 agaaaaggca tttttaattc tttagcaatc gcgtaaacaa tcggtatcaa cagaacaaga 1776421 ccgacttcaa aaaatagggc aatcccgatg ataaaagagg caaccacaac cgccgcctgt 1776481 attcgtttcc tcccgaattt gtcaatcagc gtaatggcga tccggtagcc gcccccagca 1776541 tctgagacaa gcctcccaag catcgcgcca agtccaaaca ctaaagctaa atgccccagc 1776601 tgcccgccaa ttccagtctc aattgaaaga acaattttat tgatatccat tccaagtccg 1776661 atggctacta aaaatgaaac gacaatcagt gagacaaagg tatttaattt tactttaata 1776721 atgagaaata acagaatcag cactccgaca gctacaatta aaatcggcat ggtacccctc 1776781 caaaagtgtt ttatatgatt ctcgcgacaa tgttttggcg cttttcatgc ctagatgaac 1776841 agaaagcgct ttcattaata actaaaaacg tcttggttat atgattgtta tcttttgatc 1776901 aactaatatg ttcatactaa tctcctaatc aatgactgtc aatcgttttt atgagcttgt 1776961 ctcgattacc taccgcctaa cccaatgatt tattagttat atgttgatta acttttggtt 1777021 atatgttatg ttttttaaag ttgactgcca atcattatat ctctccattg tctggaagca 1777081 aatgagacaa tatgagaaca gacggataac aacttcataa gaggaggagt acacatgcca 1777141 ttattgcgtt ttgatgtaat tgagggccgt gatgaaaaat cgctgcaatt gttattagat 1777201 actgctcacc aagcgatggt tgaagcattt ggtgttccgg aaagagaccg ttatcaaatt 1777261 gtccatcagc atcccgcaaa cgagcttata atccaggatg cgggattagg gtttcagaga 1777321 accaaggata tggtcatcat tagcatgaca agcaaagcaa gaaccgaaag ccaaaaggaa 1777381 aaattgtatg ctctgcttgc tgaaaggcta gaaaaaaaat gcgaaatttc ccctgacgac 1777441 ctcatggtat ctattactga gaatggtgac gcagactgga gtttcggtct cggtgaggcg 1777501 caatttttga atggaaaact ataagatttc gtctccccac aaaaaaaaga agagagagct 1777561 ccaaagaagc tctctctttt ttcataaatg cggaagtcat cagtatagaa gcatccagca 1777621 atacgaaaaa cctggatctc cttttatatc cggtttaaat gccaattgga agctgactgg 1777681 gttttggctg aaaatataaa attttgctga tttgcataat aagatacatc ataatcccca 1777741 tttacaatag gttggatgtt atagcttatt gatcatttcc tattttatat atccccttca 1777801 tatgcacatg acatttttgc caatccggaa atatcagtct gacaaatata aaaagtcatg 1777861 taaacgggtg tgaaccgtac ttacatgact caccatggaa acaaaggctc tttttcaggt 1777921 gccgctttcc ttatttctct tcttcacaca ctgtgtcacc aggctcgcaa aattgatcgg 1777981 cccatgcctg catttcttga aatacagctt gaagcgctgt tcctttttca gtcagcgtgt 1778041 agatgacttt gaccggcgtt tcagggagaa cctgccgttc gacaatctcg ttttgttcaa 1778101 gctccttcaa gcgctctgcc aacatttttt ggctgatcat cggtattgtt tccgttatct 1778161 ctttaaaccg tttcggccca tccattagca catggatgat cagaccgttc catcgttttc 1778221 ccagcaatga gaatgcggat tccattttag ggcacatcgt atttcccata agtcttcatc 1778281 ccttcatcta ttgattgaca tgtattcaat gatccattac aataatcttt caagttacat 1778341 ttagtaagct tctaactttt ctattatcat accacgttta tccgaaggag gaaacactat 1778401 gacgaatact ctggatgttt taaaagcacg tgcatctgta aaggaatatg atacaaatgc 1778461 cccgatctct aaggaggagc tgactgagct attagacctt gccactaaag cgccttctgc 1778521 ttggaacctt cagcattggc attttacagt attccacagc gatgaatcaa aagcggagct 1778581 tcttcctgta gcgtataatc aaaaacaaat cgttgagtct tctgctgttg ttgccatttt 1778641 aggcgattta aaggcaaatg aaaacggtga agaagtttat gctgaattag caagccaagg 1778701 ctatattacg gatgaaatca aacaaacatt gctcggccaa atcaacggtg cttaccaaag 1778761 cgagcaattc gcacgtgatt ccgctttctt aaatgcttct ttagctgcta tgcagcttat 1778821 gattgccgca aaagcaaaag gttatgacac ttgcgcaatc ggcggattta acaaagagca 1778881 gttccaaaag caatttgata tcagtgagcg ctatgttccg gttatgctta tttcaatcgg 1778941 caaagcagtg aagcctgcgc atcaaagcaa ccgtctgccg ctttcaaaag tatcaacttg 1779001 gctgtaagga tatgaaaaac cttagtccga aatccggact aaggtttttt tatacaatcg 1779061 cctctttgta ccattcacga gcctgttcag cttcatgctg agtcagctga tggcccccgt 1779121 cctgccagta aacggaggct gatgccccgc tgtcacgcaa atagcggtaa agctcttctg 1779181 attcttcctt cgtgcaaaga ggatcgtatt tcccggcacc gataaaaaca gggagccccg 1779241 ccatatcagg cagctcgata ccccgaatcg gaaccattgg atgatgcaga atagcccctt 1779301 ttaacacatc tttataatga aaaagcaggc ttgccgcaat gtttgcgccg tttgaataac 1779361 cgactgcaat cactcggccg cgattaaact gatgcgtttc tgcagcctcg tcgataaaat 1779421 ctttcaattc tcttgtccgc accacaagat ccttttcatc aaaaactcct tcactcagac 1779481 gtttgaaaaa tcgcggcatt ccattttcaa gcaccgatcc tctgacacca agcaaatggg 1779541 catcagggtc tataaaccgc cccaatgaaa gcagatcgtg ttcattacca cccgtgccat 1779601 gcaacagcaa aagtacgttg tcagatgttc ctttctcata aatatgcttc attataaatt 1779661 ccccctttta aagttcaggt aaaatgtctg taatttgttg tctatgtttc tccagccatt 1779721 caggcagttt taaggaagtc cctagctcag caaacgtttc atctgtcata aagcccggtt 1779781 catctgtggc aatttcaaat aagataccgc ctttctccct aaaataaact gatgtaaagt 1779841 attccctgtc gagaatttct gacgaaggca gatggttttc agcaataatc ggcagccatt 1779901 tcgcctgttc ctttttctta gtccgaaacg ctacatggtg taccgtacca tatcctccga 1779961 ctcctctttt ttcaggatgt aaatggacat caatgacacc gccgaccgcc gctgaagatg 1780021 ccagtctgac aatctggtct tcttcggcca ctttggtgta tccaaagctt tccgttaaca 1780081 attgtatggt cgcctgcggg tcgtaggaat atagcagcac acctttcatt cccgtaattg 1780141 cttcatttgt tgtgatcccg tcaggcgtcc actcgctttt gccgcttttc gcatcctcca 1780201 tgatcgccag cggaaggtct tctgtatcat caaaaataag acctttttca ccaaacaacg 1780261 ttttttcctc taggctcagc ccgcttttct caagacgttc cttccaaaaa gacagggagc 1780321 ctgagggaac tgaaaagtac acccggcccg cttggccttt tcctaccgtt ccctgtccgc 1780381 ttccttggaa cggaaaaaag gtcattattg taccgggatc tccgttttga ttcccaaagt 1780441 aaaaatgata cgttccggga tcatcaaagt ttactgtttt tttaacgagc ctgagcccaa 1780501 gcacttctgt ataaaatcgc aagttttctt gcggatctct ggcgaatgct gtgacatggt 1780561 gcaatccttc tgttttcatt ttctcactcc tatttatctc gatttcaaga tatttattat 1780621 tttaaacctt tattgaaaag gatgcaaacc atgtgttttg attaaataat tgaaaaaatc 1780681 atttttttct aataattatc ttgtgatctt ttcttacaac tgctattata gtgagcatta 1780741 tcatgtttca ggaggaaagt aaatggttaa aaaagcactt attgttattc tcattctttt 1780801 gccattcgtt cagctcgcgc ttttgccgct tgtgaatcga atagaaccga ttatgttcgg 1780861 cctgccgttt ttccactttt ggctgctgct gtggattatt gttacgccgt tatgctcgtt 1780921 tggcatttat cagatgcaaa aaaaagatgg aggacttgaa taatgcaagg gaatctgact 1780981 gcacttctca ttactgctat tattgtttta accgttgtct gtatcggctt tctcgccgga 1781041 agagacaaat cctcacgtac ttctgtggaa gaatggtctg tcggcggcag acgcttcggc 1781101 ggtcttctcg tctggttttt agtaggcgct gacctttata cggcctatac tttcttaggg 1781161 ttgaccagta ctgcttttac aggcggaagt gttgcatttt tcgccattcc ttattctgtg 1781221 ttggcctact ttatcgccta cttcttcttg ccaaaacttt ggaaagttgc gaaaattcat 1781281 aaattaacaa cactcgcgga ttatgcccgg gaacgtttta acagtaagct tttggcaagc 1781341 ctcgttgcca tcgttggggt actcatgctt attccgtaca tatgccttca gctgagcggc 1781401 attcaagaca cgcttcaggt tgccggcact ggctatatta acgtaaaatt cgttgtgatc 1781461 atttcattta ttcttgttgc tctttacaca ttcttcagcg ggattaaagg gcccacatat 1781521 acagccatca ttaaggacat tttagtatgg gtcattatgc tgtttatggt ggtgtccctc 1781581 cctctcattc attttaacgg ctggacgcca atgattgaca cgttagtgaa ggaagcgccg 1781641 caaatgctga cgataccgtc agaagggcca aaaggcattc cttggtttat cacagcatct 1781701 attgtttccg ctctggcact ttttatgtgg gcacatgccg ctacaggtgt tttcacggcg 1781761 aaaagcgctg atgcagtaag aaaaaacagc atgtttttgc cgctttataa tatcgtgtta 1781821 attttggtta tttttcttgg ctttatcgcc tttcttgttc tgccggaaga tacaaatcca 1781881 aggctggcgc tgctgcattt gattcaaaca tcttacggcg gcgtggcaca aggctttgca 1781941 tatgccacta tcgctcttgc ttcattaata ccttgttcca ttatggcaat cggcgcatcg 1782001 aatttattcg ccaacaacct ataccgggat ttgattcatc cgaatgtgtc gcaaagcaag 1782061 ctgactcttg tcacacgttc aatggtgttt gttgtcatcg gtcttgcgct gctgtttgga 1782121 atgctgttcc cgactgcctt agtgacactt cagctattag gtgtatccgg tatggtgcaa 1782181 atcttccctg cgattgctgt cagcctgttc tggaaaaacc aaacgaaaga agcaacggtt 1782241 atcggattat tagccggcct agcggtaacg tttattgtgt atatcactca atccgcacat 1782301 ggcatttatg aaggattctg gggattggcc gccaacatga tcgctgtggt catcctgaat 1782361 ccgctgttcg ttaaaaacgc gggatccaat cctgtcattg aaggtttatt tggcaaaaaa 1782421 caagacgcta atccaaatca aaagggcgca taaaaaaacc atacgcggca gccgcgtatg 1782481 gtttttttta catttctttt ttcagtgttt caattgcctt ttccatttgc gtatcattat 1782541 cagacagctt cttttgaagt tctatcatta atttcgttgt tgtatcgcca gtcagtatgc 1782601 ctgtttcatt cagcttctct tttttctgga actgtttgac gacagataca aaatcctggt 1782661 catacatact gttaaccttt accttgtaac caagtgcttt gagcattttc tgagccactt 1782721 tgacgtttgt gcctgtatca cctgatttgt acgttttatc tgcgtccaaa tacggcagct 1782781 tcgcgtaatc aggcagctct gctttcactt gaggcttgat gccttttttg tgaatccatt 1782841 cgccatcagc agtcagccat ttggcaactg tcagtttgac ggtagagcca tcatcatatt 1782901 cttttgccgt ttgtactgta cctttgccga atgtcgtctc gccgattaac ggtacgtttg 1782961 acgattcatg aagggcagcg gccataattt cggctgcgct tgctgtaccg tcatttacta 1783021 aaacgacggt cggcttggtc actttccgtt ctttttcggc cttcatgact tcttttgaac 1783081 cgtttttgta ttcaacctgc atgatgtttt tccctttatc aatgaacagg ttgctcatcg 1783141 taatcgcctg ttccattaag ccgcccgggt tgcctctcaa gtctaaaata tagcctttgg 1783201 cgcctttttt ctctaaactg tcaatcgcat ctgtcagctc tttagctgtt gtttcagaga 1783261 aagaagtgat ttgaatttct ccgatgttgt tgtctttcat ctctgaatag acagtctcta 1783321 caggaatggt atcgcgctta atggaaagat cgatattccc cactcccgct ctgttcagtt 1783381 caagcttcac ctttgtgccc tttttgcctc ggattaaagc gacggcttca tttacattca 1783441 tgccttttac gctttttcca tttaccttaa tgatttggtc cctcggtttg ataccggctt 1783501 tttcagcagg tgaaccttta attggggata caataaggat ttctccgtct ttctcctcta 1783561 cttgggctcc gattccttca aaagatgctg aaatcgtctc gtcgaatgat ttcgcttgct 1783621 cttgatccat atatgtagaa tacggatcat ccagtgattg aatcattcct ttaattgctc 1783681 cgtctactaa tttgtcatca tctgtttttt ggtaataatc acttttgatt tgctcatacg 1783741 ctttatttaa tttgtcgaac ttgctgtctc ctgtgcttgc tgatttttgg cccaggatac 1783801 tggaattgcc cgtaataaat aaagtaagcg ccgaagcgac aactgcagtg atcagcacaa 1783861 taaaaaacag ttttaattgc cgtttcaatt aaacaccacc tttttcttct tacattatta 1783921 tcatggacga attcttattc gtcaactcgg agcagaaatg aaagagaaac gcccttcttt 1783981 tgcttttcat aaacctatgt ctttatacga catatgataa ggaaaaagga ggattcgata 1784041 ttgagccgat atttagaaat gctgtcctta ttcggtgtcg caggggcgca cccaggcggg 1784101 ctggcttttt caaaagcggt cttgcaaaag gctgcaccct ctccggatca gccgattctt 1784161 gatgccggat gcggaacagg gcaaacggcg gcttatttag gacatttgct gtatcctgta 1784221 acagtcgttg ataaagatcc tattatgctt gagaaagcga aaaaaagatt tgcgaatgaa 1784281 gggcttgcca tccctgcata tcaggcggag ctggaacatc tcccgttttc ttctgagtcc 1784341 ttttcctgcg tcctgtcaga atcggtcctc agtttttcac gcctgacatc ctctcttcaa 1784401 gaaatttcaa gagttttaaa acccagcggg atgctgattg gtatcgaagc tgctttaaaa 1784461 aaaccaatgc cccctgcaga aaagaagcaa atgatggatt tttacggatt tacttgctta 1784521 catgaagaaa gcgaatggca taaactccta agatcctatg gctttcaaaa aacagaagcg 1784581 atgtcacttc ttccggaaga catggaattt gaaccaacca cagaaatgga tttatcgcaa 1784641 acgattgatc ccatctatta cgatacgctt caaacacatt atcagctcat gcagttatat 1784701 agtgagtaca tgggtcattg tatttttatc gcgtacaagt aaaacggcgt atcgccccct 1784761 gttttcgtcc aacctttttt tcctatctat catatgctga tagaaagtca ggataggagg 1784821 ggaacaatat tggagagata ttatcatctt tgcaaaaacc atcaaggtaa agtcgtcaga 1784881 attacagaga gaggcgggag agttcacgtc ggcagaatta cccgtgtaac aagagacaga 1784941 gtttttatag ctccggtcgg cggagggcca agaggtttcg gttacggata ttggggcggt 1785001 tattggggat atggagcggc ttacgggatt tccctcggtt taattgcagg agtggctctg 1785061 gctggtttat tcttctggta agcatagaac aaatgctaga ttcaccagac acaatgaagc 1785121 ccgcttatct agtgtaagcg ggcttttcat tttaaatttt cttcactttt tcaaagtact 1785181 cttcaagcgt taaatcatta tcttggatga cctttgcggc ttttttgcct acatagcgca 1785241 gatgccatgg ctcatattca tatttcgtga tatcttcttt atttttcgga tagcgaataa 1785301 taaagccata tttataagca ttgtcctgca cccatttccc gtctgccgtg cttccgaacg 1785361 cttcatttag ctcaaagcca ttgctccggc tcgaaatgtc catcgcaagg cctgtttgat 1785421 gctcgctttc acccgggtaa gcgaccgctt cctttgcctt cctttcccct tttaggctta 1785481 cttcattgtc aaaaatgact ttctgtctgt catacgaacg gtaccctgag acagctgcca 1785541 gttcatagcc ttcctttttg gcagcatcga acattgtttt taatgcgtcg gccgcttctt 1785601 ttctgatgta acgtttttga atcttttctt caaaagaaaa ctctacatca ggtatgacaa 1785661 gatcgctagg ttcatagttt ccgggcagtg catattgttt attgacaagc gcgagtatat 1785721 tttctggatt ttgaatggtt tccagaccat cgactttttt aatatcattg aaatactggc 1785781 tttccaatga aaactcactg ttttgagtgt ttgatttttt gctgtcagct gttttttgtt 1785841 ctgtttgctt tgtttctgct gtggttttcg tatccttttg agcatctccg ttcgacatgc 1785901 tgcagccggc tccgactatt gccgttacac tcagagcggc agccagtgag aaccatttac 1785961 cggacttttt catattacat taccttcctt ttatcaatcg tttccgcatg cataaagaag 1786021 aggctgccgg cacccagcac gcctcttgat atattttatt gtgatacgga atgtaaagcc 1786081 acttctatca tatcatgaaa tgtcgtttga cgctcttccg ctgtcgtttc ttctcctgtt 1786141 aatacgtgat cactcacggt gagaattgac agggcttttc ttccgtgctt cgctgctaat 1786201 gtatacaatg cagttgtttc catttcaacg ccaagcacac cgtattttgc aagtttttca 1786261 atttgcgaat cgtcattgta gaactggtca gctgtaaata cgcttcctac agtcaccggc 1786321 acacctttat cctttgcggc atcataggca ttttttaaaa gctcgaaatc tgcgcaaggc 1786381 gcaaaatcaa cgcttccgaa agcaactctg ttcatttgtg aatcagttga ggaggtcatc 1786441 gccaaaatga cgtctcgcac tttgacatct ttacgaatag cgccgcagga accgactctt 1786501 attagatttt gcacatcgta gctttgaatt aattcattca cataaattga aatagacgga 1786561 actcccattc ccgtgccttg tactgagatt tttttacctt tatatgtacc cgtaaatcca 1786621 tacatgcctc tgacttcatt gtagcattct acattttcaa gatacgtttc tgcaataaat 1786681 tttgctctga gaggatctcc cggcaaaagc acagtatccg caatttgtcc tttttcagca 1786741 cctatatgta cactcatctc atatcctcct gtaaatctaa attatcatcc agcccgtcca 1786801 ttttacaacg aatgtcatga tgaaacaaac ttcagcattg attataaagg aatatatcga 1786861 aaaaagaaat gttcgaggat ctgttaggca cttcctcaga aaaacggata atcggggtgt 1786921 taatttgaaa acctaaccgc aggaaggagg ggtgggacat gggtaaaaaa catcgtaacc 1786981 ggatcaccgg ccaaaaaaag aacaatcata tacctgaaaa agatatcatt gcagctgaag 1787041 aagcacacgg gaaagaatat tccgctgcca aacgcaagcc ttaaaactgc agaaaactgc 1787101 gggtttccgc agttttcttt tcattatgtc gtttgtacaa tcagacgatt gattttcctc 1787161 cagccggcgg gaagcagttg ataatatgtt ttcccttttc tgccttcatc aatcaggatc 1787221 acgtcccctg tggccatgaa tcttgcatca taatcactcg gaacagtgtc gaatacatta 1787281 aacaaagaga atgctctttt cagcacgtct tgatgatcgc tcccgttcag ttcagttcga 1787341 tagacggctc tgtagccctt tttttcgcca aaccggggtg tctgaaatat tgtcacgtca 1787401 taggaacaag acttcttttt aaacacggat aacatcatca agatcccctc ccttttattt 1787461 ctttaacata ttggcgtttt tgctgtgttt tcctctctct atttttgtcg aaaccgctta 1787521 atcttttcgt caaaaccttt tactaggaaa aacagaagca agccgaggct aaagcctcct 1787581 aacacgtctg tcacaaaatg aacccccaga tacactctgc ttatgccgac taaaacagca 1787641 attacaccgg ctatgatata taccattttt ttatgcttag acaaaaacgg gagatgtttc 1787701 actaaaaagt aagcaataac aggatagaca caagcagcat tcatggaatg gccgctcgga 1787761 aaactgaagg atgattcatg aaccagcggt gcaaaatcag gcctcactct ttcgatccat 1787821 tcttttaaga ctttgtttaa cagccgatct gtgccgaata ctaagagcat caacaggccg 1787881 tcccatgttt ttctgtagaa aaacatgcct gctccaatga tgacaattag agggagcaga 1787941 aaagaagaag caccaagatg cgtgatcccc gtcatgactt cattaagcca tggctgacgg 1788001 atcaaaacag ctgccttgct tattgcttca tctgcagatt gaacagcatt tgtatgaatg 1788061 gccgcagcta gaattaaaaa gaaaagaaac aaactaacgg gcttgtacaa ttttaaccac 1788121 ctcaattttc acagaagtca tagaacatga ataataaaac cggagctgac cgctccggtt 1788181 ttaagcctca ctcatcttca tccagctctt catctatcat acatttttct atcaaataat 1788241 caaaggtaat atcagcgatt tcaaacagct catcctcact cggtatgtag ccccgtcttg 1788301 caagctctct gtaaaaaaat tcagcgattt cttccgtatc aatcacaaga tctatttctt 1788361 tcatctccgt accgcctcct tttttatgtt ttatgaaaaa acaggctgaa ttatacccgg 1788421 tgttctaaac aattctttca gtcatatatt gaataaaaaa cgagccatgg gaggctgacg 1788481 ctatgattgc taaaatgatg gaagcactgg acggagaaag atttgatatc ataatggaaa 1788541 aaacgctcaa aggaatgacg cgtgtgatga tttggggctg tctgccatat tttttatatg 1788601 tcttgatccg tatgttcaca aattaactga aatgctcttt taaactttcc aaaacaaaca 1788661 tcatcatgtc tttatattct tcatcctgaa acatttcgta cagaattttg tagtcattat 1788721 aaatatccag aagctcatca acaattgaca cagcaaggat gtgaagggta tcttgatctt 1788781 catcaccgcc ttcaaactga agaagagcag acgatgcgat atcttcgccg atctcatggc 1788841 cagtttctcc gacataatgg acaaacaaca gctgatgcac aaactggtcc atttcatatt 1788901 ttctaagcac cagcgtgaga tcctcttcct ccgtttcaag ccactctcca tcctttaaac 1788961 gggtcagctc ataaatgata tcttcccagc catcttctaa atatctccaa atttctgttc 1789021 tatggccgat aatgcgaaag agttcttttc cataatcttt aacataaaca acgtccccaa 1789081 taaggaattc atactcaata tcaagcttct ccatgtcgac aatgacaccc tcataatctt 1789141 tataaagctg aatagatgat tcaaagtata aaacttcgtt atgattgact tcataaagat 1789201 agtgtttatc aatttggtgt acttttgtga tggtgccgac tgttccatac ataatgacga 1789261 ctacgatatc ccctacttgg aatttcggtt tattttgctt catggtgtct ccccctcgcc 1789321 gcaacatttc tcatacgcta tcgtatgccg ggtgaagcca attcgcatgg gcatgaaaac 1789381 caaaggaaat atccaattat ggtatgggta tggacataaa aaaatccgca gtgatctgcg 1789441 gatgaaacag ctattatctg ccgtgcactt cagactcgta ttgatcccaa gcttcatcaa 1789501 acgtcgccat cgtgtgaagg taatcagcat tcagctccaa atatgaactg atttcatgat 1789561 aatcggttga tgtttttgga aagctgtgat cctcatacgc ctgattggca aattcactga 1789621 tgctgtcctt cggcttaggg tgtctgtatt tcaataaata gtgataaaag gatttcatgg 1789681 gtttcccctc ctgatgtctg tcttttgttg ttctattata cagttcaagt gtaaaattac 1789741 aacaaaagaa tactgaaaca tgactcagga gaagtcaaaa tagttgcgtt tcaaaattct 1789801 ttctgtctcc atgagctgct gatatgtcag gctttcaggc agtttttttg tttgaattaa 1789861 aagcagctga tcctcaatct ctttaaccgt gttttcctct tgataggtca taccgcagga 1789921 agaacatacc atggcagggg tgtctgtcag ttctatagcc ctcgttccat cagggagctc 1789981 ccagtacacc gtgttcctgc cgggcaccgc ttcgagctcg ccgcaccatt cgcatgtttt 1790041 catgaagaat cccctccgca ttcagtctct ttctgttttt tctgctgcgc caaaaatttc 1790101 ttttctttga gctgatctct tttctcacgc cgatctttta atgtttcatg ctccggattt 1790161 gcgatgtatg cctctctcct tttgattctg tctacatttt caggtgtaaa cgaaacttct 1790221 ttgtcagcaa aaatggcact cagcccgatc ggctcctttt tgtcagcggt ttcagggaaa 1790281 acggactcaa aataggcgtc tgcctgattg gggatataat tctctggttc cggatatgac 1790341 gtaatcacac cttcaaaatt tcttaagatc actttgtcag gactttgtga caggacatag 1790401 tttggctgca gggcgatttt acctcctccg cctggtgcgt caacgacaaa ggtaggaacc 1790461 gcatagcctg aggtatgacc tctcagccct tcaatgatct ccaaaccttt ggaaacagga 1790521 gctctgaaat gccctattcc ttctgacaga tcacattggt aaatataata aggacggact 1790581 ctgattttta ccaagtcatg catgagcttt ttcataattg gaaccgaatc attaatacct 1790641 gctaatacga cagcctgatt tccgaccggc actcccgcgt tcaccagctt ttcacatgcc 1790701 tcaacggatt cttctgtcat ttcgatgctt gtgttaaaat gggtgttcag ccagaccgga 1790761 tgatattttt tcaatatctc gcacagatga tcggtaatgc gctgcggaaa gacgacggga 1790821 gctcttgttc cgattctgat gacttccaga tgcggaatgc tgcgcagctc ttttaaaata 1790881 tattctaaaa tttggtcgtt gatgagcagc ccatcaccgc ctgaaattaa acaatcgcgg 1790941 atttcgggtg tttcccggat ataagcaatt gcagcatcaa gctgtttttt ggggacgccc 1791001 attccgattt gtccggaaaa gcgccttctt gtgcagtagc ggcagtacat ggaacattga 1791061 ttcgtgacaa gaaacagcac acggtcggga tagcggtgtg tcagaccggg taccggtgaa 1791121 tcttcatcct catgaagcgg gtcttccaga tcgtattttg ttttgtgcat ttcttcagaa 1791181 agcggcacag actgcatgcg taccgggcat ctcggattgt cggggtccat taaagaagca 1791241 tagtaaggtg taatatttaa ggggatcgtt ttggtagaaa ttctgacgcc ttcctcttca 1791301 tcctcggtca gattaatgac tttctttaaa tcatctaacg ttcttacagt gtgtgtcagc 1791361 tgccaaagcc aatcgttcca tttctcttcc ggaacgtcct tccataactc gatctccttc 1791421 caatgccgtt tcggtttata ccatttgttt ttcaaacgaa ctcctcctcg cgcatatttt 1791481 gacttacagt tgcttgcacc aaatattcat gttttcaagg ccttcggcta taaagcaatt 1791541 attgatcagc cttccgccat actgataacc tgaatggtac aacacagcat tcatcccaaa 1791601 agacgaagca cgggcgagag aaaacacatg aacgatatcc tctccagcca tttctttttc 1791661 taacgcctcg attaaaaagc ttgttaacga atggccgcga tattccggca gcacagcgca 1791721 atcggttatt tctgcatgcc caagctctgg attgatttct gcgcttgctg cgctgatcag 1791781 gcggtcatga tcaagcatga tataatacac cgtatttgca ttcatcgtct tttcaatata 1791841 agcggggtca aataccgggg ttgggtacgt gcggaatact tttttataca gcatcgatag 1791901 ctggtacatg tcgtttgttt ctgcttttct catcgtaaaa acgggtgtac tgtcgttgcg 1791961 aagacggggc gctgtgcgat atatggcttc gatgatctcc tgttcctctg tataagaatc 1792021 tgtttgtctc cggctttctg aaaggtaacg taccatgaca caagccgaat ggccgagata 1792081 atagcccttt agatagccct ccggcgcaaa taattgtttg gcaaggatcg gctcatcatg 1792141 ctgcttcgca tagacaatga ttttttctgc attctcttct tttgccgctg ccacgatatc 1792201 cggcagggcc ttctcaatgg ctccgtcata acgaaccact ctgattcgtt tattaaagcc 1792261 gtcatggtcc aaaactgctg tgacaccgct actctttatt gacttgagca tccgcatcct 1792321 ccccatctgt atgaaggccg caccaatcca tgacaaaaag tgcaataatt ttagcagatt 1792381 ctatcatggc ttcaacctca atgtattcat tggcctgatg agccgttttt gtttcccccg 1792441 gcccgaaaac gatcactggt gtatctcctg catggtacaa aagccctcca tccgttcccc 1792501 acggggaagc ctcaataatc ggctctgtct gtttcatttt ttgataggct gattgcagca 1792561 cagaaattaa agggtgatca tcaggtaaat cattcggcag ccattgagcg ccaaaccatt 1792621 cgacttgtac gggatggcgt ttaaaccatt cgtcatggta ttctaaatcc ttcagccagt 1792681 tttccaattc aagttttaca gcttctggtt tctcatgggg agcaattccg catctccctt 1792741 ctatgacgac acggtctgca actgaagatg gccaggcacc gcctgagatg gtgccgatat 1792801 tcaccggtac cggtattggg atattgtcat acagcggatc tgaaattctc gcattgcgga 1792861 ctttctccag ctcttgtatc gctgtgataa cgtgcatgct tttttcaatc gcgcttaccc 1792921 cttcatagcg tgtgccccca tgtgcggata atcccttcac agtgatccga aaccacatcg 1792981 aaccctgctg cttaataaat agtttcatat tcgtcggttc aggaatcagc gccccgtcag 1793041 cacgatagcc tctcatgatg gcggaaagtg taccggcgcc gccgcactct tcatctacaa 1793101 cactctgaaa caatacatct cccttcagtt tgacatcgca ggcgtgcagg gcttctaaag 1793161 caaaaagaag ggctgtattg cctcccttca tatccgttga gccgcggccg tatattttac 1793221 cgttttcttc gacagcttga tacggttcat acttccaatc ctttacgctt ccttcaggca 1793281 caacatcgat atggccgttc aaaatcaggg acctgcctcc gccggctccc gtttttttag 1793341 ccacgatatt cgggctctca tgaaaatcgg atcggttaga tttaaagtag ggatgctgtt 1793401 ttaattgctt tatgcttggc tcccatacat caatgtccat atgaaattgc cgcagctttt 1793461 caagcacaac agcttgggcg ttaaactctg accccaatgt gcttttttcc ccaatcagcc 1793521 ttttgagaag acgaatggct ttggccgaat gctgatcaag ccactcgatt acttttcttt 1793581 caatgtcttg catcctcatt ccccctctta agaaaaaggc atatctattt tgatttcagc 1793641 ttctgtcagc ctcgtcacct catcgattgt cgagccattc atcagctctt ttaaaatgaa 1793701 gtgatggcta tcgacctcaa gaaccgcttt ttcggtaata atcaaatcta cacagcctgc 1793761 agcagttaat ggcagcgtac atctttctgt taatttaggc cttccctttt gatctgtatg 1793821 actcatgacg acaaccactt ttttcgcttt ttgggcaagc tccatcgccc cgcccatacc 1793881 aggcaccttt tttcccggaa caagccaatt tgccaaatct cctgattggc tcacctgcag 1793941 ggcgcctaaa atcgtaatgt caattttgcc ttttctgatc atcgcaaaag acatggttgt 1794001 atcaaaataa gaagcccctt ttacagcgcg gacaggatat cccgcggcgt tgcataaatg 1794061 cgcatcctct tctccctttt cgggactttc tccaatgcca aggacaccgt tttccgcttg 1794121 aaacatgacc tgcatgtcag gcttcaaaaa gttcggtacc aaggaaggga taccgatacc 1794181 gagattcaca atcatgccct gcttaatttc agtagcagcg cgttttgcaa tctgttctct 1794241 ttctgctact cccaagccca tttccacttc actccctcgc ttcgtacaac cccctcaaca 1794301 aaaacccccg gtgtgacaat catttcttca gaaatctccc ccatcggaac gatacgctca 1794361 gcttcggcaa aggttctcct ggcggccatt gccataagcg ggttcatatt gcgcgcggtt 1794421 ttgtcatacg ttagattgcc gaattcatct gcaatgtaag cattgatgaa agcaaaatca 1794481 gcagtcagcg cctcttcaat caagtatcgt tttcccgcca ctgttacgat gtcctttttt 1794541 tcgcaaacca tttgattatc aatgcccacg tcggttaaaa taccgccaag ccccgctccg 1794601 ccggcgcgaa tccgttccgc aagcgttccc tgaggtgaaa attgaacctc taacgtcccc 1794661 tctgtcatct gttttccggc tactggattg gaaccgatat gcgaggcgat cagggttttg 1794721 acccgttgat taacaataag cgggccgatt ccgatatccg ggaaaccggc gtcattgcaa 1794781 atcacagtca aatccgttac accgctgtcc aatatcgctt caatcaatga aggaggcgac 1794841 ccgactcccc caaaaccgcc aaacatcaga accgatccat cccgaacatc tgcaattgct 1794901 gtgtcaatgc tgattgcttt ttgaaatggc gccatttaat gtcaatcctt ttttaagttt 1794961 ttttcgaccg ctgcaactgt ttctgaaaaa atagagataa gctcttccat ttcaccgtct 1795021 gaaatagtaa aaggaggagc aataatgaca gcatctcctt ctccactgtc tattccagct 1795081 ttggaaggat aaacaatcag cccgcgtttt ttcgcctcgc tgacaataag ctgggttatc 1795141 gcctgctctg gcggaaacac tttcttcgtt ttttggtctg ccacaaattc aatgcctaat 1795201 agcagtcctt ttccgcgcac ctcacctata atgccgcttt gagatgccgc ctcatcaagc 1795261 ttcttcttca gcacagcgcc ctttttttct gattgtttga tcaagccgtg ctttaacaca 1795321 tatcgcaaaa cttcaagagc agctttggct gaatagggat gtgcactata tgtgtgaccg 1795381 ctcataatca cacctgaccc ttgttttatg gtttcaataa tagaatcaga tacgacggca 1795441 gcagcaatag gtgcataccc cgcaccgagt cccttcccca gtacagcaat atcaggtacg 1795501 gtatcccaat gctctgtcgc gagcatcctt cctgttctcc caagccccgt catcacttca 1795561 tctgcaataa aaagcacatc gtgtgtgcgg catacctcac ttaatctctc ataatatccc 1795621 ggaggcggag taatcgctgc tcctgcagca ccaataatag gctcagccac aaagccggcg 1795681 atgaattggc ttccgattct tttaatcatg gtgtccagtt catcagctgc agtctgaaca 1795741 aagtcttctt ccgtctcgtg attcagccga taaatatgtg gagctgagat agctggatac 1795801 cgctcaatga gatgggtgaa ccggtatctc ctttcataaa aaccagacaa tgaaagcgct 1795861 cccaaagtta ttccgtggta actgctccat cgagacaaaa agatggattt ttgtgtttgc 1795921 tttttttcct gccaatactg aatggcgatt ttcatagctg tttctatcgc ttctgatccg 1795981 ctgttgacaa aaaaagacca attcacatct ccgggcagct cctgtgccaa gagagcggct 1796041 aattgctcgg cgggctcact cgtaaactgt gagcggtaag caaaagacac ctgatcaagc 1796101 tgttctttca gcttctcagt cacatcacga actccgtggc cgatattaca tgtcaccgca 1796161 cctgacgagc cgtcgagata tttttttccg gtctgatcat aaacatatga acccttcgca 1796221 taactgacaa ccggataggc cgagctaagc tctggcttaa tcaaataact gctcatgctc 1796281 ccacctcaaa acccctttta ccatattgta tgagtgtcca aatggcggca tgacgttccc 1796341 cgcaaaaact ttttcacata aaaagagcct tcctaataag gaaggctctt ttgaaatttc 1796401 agcatctagc aaataaaagc ggctccaaca ataattaata aaatgaacaa gacaacaatt 1796461 aacacaaatg tatttgtccc gcagccaaat ccgtaaccgt acccagagta tccatacatg 1796521 ctgttttcat cctttcttat cacgatatac gacattttat gcgggccaag tcccaaatgg 1796581 tttgtgcaaa cgcctatttc atgtaaggaa ataatgaaat acagtatgca cccgctcata 1796641 ttttttaaac gtcagctttt cgtaaaactg agttgcaccg tcagtgcttg cagccactaa 1796701 gtaggctgct tccattccta gtgatttggc gatggacagc atttctttca ctaagatact 1796761 gccgtagccc ttcctttgaa actgatctaa aattgccact tcttcgattt tagccgtttt 1796821 ctcttgatga tcgataaaca gctcgccgca cccaatggga actttctgtg cctggtcgct 1796881 gtaacaaaca acaagaatga ttatatctgc ttcatagaaa ggatattttc tttttaattt 1796941 ttgttcagcg attgcttctc caatataaat ggaatcgtaa attttcataa tagaagatcc 1797001 gtcgctaaga ctttttgccg tcccccatgc ggttaaagga tgtcccatct gccccttcca 1797061 gtcactaagc ttcatgtcat atagtagctc atcctcgacg acaaaaccgc tttttacaag 1797121 tgactgcttc aaaccgagcg gaaaaacatg ctgcggcgac gcttttaaat ggagataatt 1797181 cgcatcaagc agctttggta cggagggtaa aaagttaagt aaccgctcca atggaaacgt 1797241 atcatggagc tgaacaaagt tatgagaaaa aatttgcgga agctgcggat ctctgtatac 1797301 gctgtaatga tcaaacgatg ccgattcaga cgttaacaat atatattgat gttccgtttt 1797361 tgaataatgt cctgtcatga acgtctcctt tttatgacct atacctttac tctgttgcaa 1797421 tattcaattt ctttataatc tcatcgtaca ccggataaaa cggctttcca attggaaatt 1797481 gctgaatatt tcggaaagaa gcggagattg gcttctgatg taaaaaaaac ttccttgtta 1797541 cttgttcact aatcgggtga aagacgccgt ttagaaacaa aaacggctcg cgttcgatga 1797601 aaaacagacg tcggccaggc ggatttttga tcaattcaga tcgtttccac gtaatcggcg 1797661 gcccttccgg aagcgtctcc atctcttctt ttccaattgt cactatgtct tttctttgaa 1797721 attgataaaa ttgaaacgca tactggtcca caattcgcct tttttttccg gcttcgatat 1797781 aaaatattgc aggatggtca gcttccttta ctaaaatata attcggaatg tttaaaattt 1797841 tgccaatcct atattggaat aaatatgggt ctggaacagc gacagtccga tttagataca 1797901 aaaaacccca cttttctcca acaggatgcc ttacaccctg atcaaaaaaa tacacatttt 1797961 gatctgaacc ttttacaaaa gagccgtcaa tcaaatcggc gggcagaaac cgatatgcat 1798021 tttgaaatga atctggggtt ttataggttg tgtctaatac ttcatttatc ggcagaaatg 1798081 gggtaaagtt gttgagtctc gcccaaaaaa ttgcgtcgcc atgattccaa tgcttcatat 1798141 catcatccca gtagcctcca aatttatggt gaatgagatt aagtaacgaa cggcgatgca 1798201 taactgagca atgatcaact tgaaaagcgg cctgatcaag cactgcattg gcatttctgt 1798261 agaaatgtga gatttcctct cccctttcgt ttacatgtac aactttttgt tttgaataga 1798321 ccgcctgcgc ttcaggctta tgtgaaaact cttgcaccat acggctcagc cgctcaggat 1798381 gataaacagt gtcgtcagta agataggaaa tgtaatcgcc gtctgcaaat gggagcgcac 1798441 tgttaattaa tgtggcataa cgggctgttt ttaatcgatc tgcaggatgc acgaaactgt 1798501 tatgatattg aatgcgccgg tcatggagat acttgtgaat caccgcagtt gtttctgcat 1798561 tcgaatgatc atccatgata aaaagctccc aaagatcatg cgtttgctgt atcacgcttt 1798621 cgatcgcttt ttgcaaataa tcgggtttgt tgtaacttgt taaaataata gacactttct 1798681 ctcccatcta taccgcctcc cgccgtcaaa cataaaaacg gctccgcagc aagcagagcc 1798741 tctgtcatca tttaaaaagc accccagctt acaacacttg agagtgaaac atgagatctc 1798801 gtgttattta acgggttttg gaaaataacc aaatcagtca gaacttcttt tacgatgaca 1798861 ttttgaagtg tatctccgtt gatcaaattg acttttgaaa ccggtacgcc cagctctttt 1798921 gcaaaaacaa gctggcgtct gaggtcagat ggatttcctt cagaagacga ttgacgtatc 1798981 agcagaatca gcaaaagcaa aataaaatgc agatcatctt ggttttcttc tcgatccact 1799041 tgtttctcta aatccaaatc atccctctcc cttatcctta tctctgtttc acaatatgtg 1799101 cgacttcgat ttatggtata ggctatgtcc actccattaa aaaatcagca ttttccttaa 1799161 atagatgaaa aatagatcag gtacggcgtt cgactcatac caaataacag ccggaagaat 1799221 atgaataacg tgagttcact atcgaatagg aggtgtgtgt aatgagctct gaaaatgcac 1799281 agttaaaaaa ggatttaatt aaagccgttt taagcccttt atttccaact gcaacagaag 1799341 gaggagaaaa tatggatagt aatcttaaag ccttgcttga tgctgccatc gatcaaaaag 1799401 tagatgaaag tgaaacggtt acggcagaat ctattttaga cccttctctt ccggcaagat 1799461 ggatttttgc cagaattacg ccaggcacta caatcagcat tgtgactgat tcaggtgaca 1799521 tgatcggacc ggttgttttc gttgctttcg atcaggttca cgggatcgta tttgtaacac 1799581 aggaaagctc cgtcactccg gcaggccaag ctacaacatt aattgatgta gacaaagtag 1799641 aaagcgttac gttcttttca taacatccga tgaaagtctt gtatatccag tcgggatacg 1799701 gaggaatata cagttatttt gatcgctggg ctgaagaatg ttttcagaac actcatacag 1799761 agtatatgat tgcagataaa cctgaagcag aatctttgat gaagatcgaa gcgtttcagc 1799821 cggatttcac acttatgatg gttggagacc gcgttcctca cgactggctg acctggttaa 1799881 agggtaagga tatccccgtg tatgtttggc tgaccgaaga cccattttat atggatatca 1799941 gccttcaggt aattaagctt gctgacgcca tattaacgat agaacaaaat gcagctctct 1800001 actatcaaga gctcggctac cagaacgtct attatgttcc gataccagtt aaccatcggc 1800061 tgtttaaaaa aatgggcacc gaacattcct atcattcaaa tctgttaatc atcggctatc 1800121 cttaccctaa tcgggttcag cttatgaaag aagcggtcca tctgccattc acggttcggg 1800181 taatcggcaa ggaatgggga aaatatctgc ctaaaaaagt gctcaaacag ccgcatattg 1800241 atgtcgtcag cacatgggtt ccacccgaac aggccgttca ttattataat ggggcagaca 1800301 tcgtaattaa tgcgcatcgt ccctatcatt ttgctttcaa ccaaaatact atgcgcatca 1800361 aaaatgccag ttttaataac cgaacgtttg atatcgctgc atgcgaagca tttcaattaa 1800421 cagatttacc cgcggcgcat cctttttcat ccattatttc ttatcacggc atgaacgact 1800481 ttaaggaaaa agccgctttc tatatcaacc accctgaaga acggcaaaaa gctgcagcag 1800541 ccaattataa agagaccgta cccgcattta cgtttgatga gcttcctgca aaactaaaag 1800601 cgattcatct ggcgctttct tgaaaaatcg ttcattgcta tgaacgattt ttttattcat 1800661 agaaaaaagc agctgcacaa gctgctttct attctagccg tcagaacggt ctttcagctt 1800721 cctcggattt acctgtttat gaagatcagg catttcgccg agatgctgtg caatttgttc 1800781 ccacgataca attttgaaat tttgattgac ggcttgtccg ttatcaatat tttcgccgtc 1800841 ctgcgccaca aaaatcccgt acggatattt tgggccaagt ccgaaaccga gaacatcaat 1800901 accatccgtg tcactagtac cgtctatctt ctcgccatct gtaatctcaa agttggctac 1800961 atagcgattt ttcccctgcc gttcatacat tgcatagctg ttatttcctt gacttgaagc 1801021 catgagatat cctttgccat ttggtgcata atagattgtc agtccttcaa tatcagctgt 1801081 caaatgatct cctgtcgcac ggtcaacaac ctgccccttt gaccctccgc cgggctcagc 1801141 gttaaatttc cagatggcct catcttcctc tgctatgtat aggtttccgt actcatcatc 1801201 cgcaacaagg ccttcggtct gagaattcaa cttaaattca cgcacctttt tccctgttac 1801261 ataacccttt ccaccatcaa caatttcata ctgctcaaat tccccttgtt tgcctgtcac 1801321 taatgcgtaa aatgctcctg ttttctggct gtgatacaag ctgaatccat aaacctcaga 1801381 aatattggtg gaaataggat ggttcggatc tgtaatgctt ttcaattttc ctttatcccc 1801441 gtctattgca tatacttcaa ttgtattttt tccttcggac cggttggatg cggcagcaat 1801501 atcaattttt tcgccgttca atggaaaatc atagcgcaga tcgacattat tgagcttgcc 1801561 aaactcataa gaatgaagct gttttccgtc taaatcatac acaacgagcc ctgacttctt 1801621 atttgttgta atcaacttgc ttttttccgg gtgtttttca tgaacccaaa tggccgggtc 1801681 atctgctgca tcatcgccag atgcgaccgg atctgtctcc gtgtgtgcag tcactttgaa 1801741 atgatgttcc tcattcacat aatgagccga caccgaggtt gctgtcaggc taagcaataa 1801801 acccgcggca gtgcttagca gcattgtttt tggaaccttc atttggtacc ctcctctttt 1801861 atcactaaca ctactattgt aaaatatata caggtgatta ccgtgaggaa aatgaacctt 1801921 tttttatagg gtttctgact cataaacaac ttattcccca aagaggtggt gagatgactt 1801981 tgccagattt acttttgcgg agcgaaataa aaatatgttg aatatttagt acattattta 1802041 tttagttttg tttttcccta gttacgtccg tttttccatt ttctattaaa aaagaacact 1802101 ttgtgacatg atcattcccc taaattttgt tttattggtt gctttcatta attcgattac 1802161 aaagttgaac atatgatgca tggtagagaa acgagagttg gaggataagc catgcctaaa 1802221 cagcaaacag cagaactaaa accatttttc cataacaaaa cagttttagt cactggcgga 1802281 acgggttcaa tcgggagtca aattgtcaaa cgccttttga tgcttacacc taaacaggtg 1802341 attgtattca gcaaagacga cagtaaacag tatgtcatga gccaaaagta tgcggaggat 1802401 aagcggctat tatttgtact tggagatgta cgcgatcaca gaagggtgaa tcaggtgatg 1802461 aaaggcgtcg atatcgtctt tcacgcggct gcgctgaaac aggttccgac atgtgaggac 1802521 catccatttg aagcgatcca gaccaatctc atcggcggac aaaatgtggt ggaagctgcc 1802581 ctttcacacc gagtgcagca tgtcattaat atcagtacag ataaagctgt atctcctgtg 1802641 aacacaatgg gtgccaccaa gctgttatct gaaaagctgt ttcatcaagc aaaccgccac 1802701 gtccaaaaca aaggaacctt gttttgttcg gtccgctttg gaaatgttct cggttccaga 1802761 ggttcggtca tccccatatt atttgaacag atgatggagg gtgaacctct gaccatcaca 1802821 gacaaaaaca tgaccagatt tttcatgtca atagacgatg cagctacatt gacattacaa 1802881 tcggctgcta ttacaaaagg cggagaaacc tttattttca aaatggaatc actgaaactt 1802941 gaagaactga ttcatgggtt tgaagaatat gcatcgcagc acgggctccc gcggccggct 1803001 gcagtagaag tgggcaagcg tccaggtgaa aagcttcacg aagaattaac atctccacat 1803061 gaaattgaat cactgtatga atggggcaac ctttatgcga tccttccaga gccggaaaaa 1803121 catcctgact ttcgcaaagt caatctgcct gggtatcaat cagatcaagc cccgctcatt 1803181 acgaaagaaa gaattgctca gattattgaa gaattgcatc aagagaaaaa ggcataaaaa 1803241 caagcctgtc tatccattag gcaggcctgt ttttaacagt ttatttatta aagagatgca 1803301 gatagctttc gtatccttct tcttttagct tatgcttcgg aacaaaccgc agcgctgctg 1803361 aatttatgca gtaacgaagt ccgtttggcc ccggtccgtc attaaatacg tggccaagat 1803421 gagaatcagc agttcggctt cttacttctg tgcgaatcat gccgtggctc gtgtccagtt 1803481 tttcttccac ttcttcttca atcggctttg taaagcttgg ccagccgcat tgggaatcaa 1803541 atttatcttt ggatgtaaac aatggcttgc ctgacacaat gtctacatac aacccttctt 1803601 ccttatgatc ccaatattca ttttgaaatg gcggctccgt gccgttattt tgcgttactt 1803661 catattgcat gcgatttaat gactttattt tttcttcttt attgtacgcc atttatttag 1803721 ccccccaatg ctcgctgata aatcccgctc gtccggaacc tgtccggtag cgctgataat 1803781 gtgctggatt ctttttataa aaatgctgat ggtagccttc cgcttcatag aaaggttcag 1803841 cttttaaaat gtccgttaca atcggatctt taaagatgcc gctttccgcc agacgttgct 1803901 tggaagcttc cgcaagctcc ttttgtttat cattatgata aaaaatggct gcgcgatagg 1803961 aactgccgcg atcagcaaat tgccctccgg catctgtcgg atcgatttgc tgccaaaata 1804021 attcaagcag tttttcataa gggaatacat caggatgaaa cgtgatttga acggcttcac 1804081 gatgtcccgt cgtttcactg cacacctctt cgtacgtagg gttttcagta tggccgcctg 1804141 tatacccgga caccactttt tcaattcccg gctgttcgtc aaaaggttta accatacacc 1804201 aaaaacagcc tcctgcaaat gtggcgattt cttttttttc agacatactg gtgcctcctt 1804261 tgttaatacg tggtattatt atattatagc atgtaaaaat agaatgaaaa tgattctgct 1804321 tttcaataaa atctataggt tttaagcaat atgcttatgt aatggaggtt cacaaatttg 1804381 aaagtaagaa cacagatgat gtacgatatg gaaactttac tccgtaaagt ctttaaacaa 1804441 atacgcaatg aaatcaatga aattttagat aaagagctgt cgcggaatga attcaccatt 1804501 cttcgaatcc ttagtgaaca agggcctaaa aaagtcactg aatttgcgcc tattttagag 1804561 gtatcggcaa gccacattac ggctgtgacc gatgcgctgg tagaaaagga atggattacg 1804621 agaatcagat cgaaggaaga cagacgcatc atccgcattc atatcactga agcgggcgaa 1804681 aaagtccttc agcactttaa cgagaaaaaa acggaatatt tctttaaacg ctttgactgc 1804741 tacactgatg ctgaacttgc cacgttaatc gagctcttca gcaaacttga taaaaaacgg 1804801 tgaaaaaaag cacataccga tatataggta tgtgcttttc gcagtgcttc acttattttt 1804861 cagtaaacag cttcattgct ttccagcggc catatctata atacaaaaat gccgcgcagc 1804921 tgctaaataa aaaactcatt ccgattccaa gcccgattcc tttttgtcca agccaagctg 1804981 aaaatagagc tgtgaaagga tacctcaaca cccaaaacga gatcaaattt aataccagaa 1805041 cctgcagcat cgctcccgcg gccctgacga ttccgttcag cacaaaatta accccaataa 1805101 aagggtagaa aaacgcgatc cacttcaaat attgttcacc aaatgcgacc gcatcaggct 1805161 cactgataaa taaccttatg aggtatttac caaataccca aatcataacc gcaatcacca 1805221 gcatgcagga aataacagct atcacaccta gccttgcaat tgttcccact cttttttcgt 1805281 ttccgattcc aatattttgc cctgccatac tattgacggc cgtaccggca gccattgctg 1805341 gaagcgtgat gatgctatca agccgctgca ccgcgccaaa gcctgatacc acgtgatccc 1805401 cgtatgagtt aacaacactc ataatcgcca tcataccgcc tgtaatcacc atcatctgca 1805461 gacctgccgg aatcccgagt ttcaaaatca gcgcggactc ttcccacttg ggcattctcg 1805521 gaatcgagaa tggcacaagc ttgtgtttga tgacataaaa caacccatac aaaaacgcaa 1805581 tgccctgtga caaaatcgtt gaataagccg ctcccgctat tcccatgcgg aacacagaaa 1805641 taaagagcgg cgcaagcact gtattcagta caacagcaaa cgcaataaac cggagaggtg 1805701 tcttgctgtc gcccagcgca cgaagcacag tactgataaa gttataacca aacaaaaata 1805761 aaatgccgat aaattgaatc tgtaaatacg tctcagcaag cggtatcatt gactccggcg 1805821 tttttagaag acgcagcaaa agctctgaga gaaaaaaacc ggccgcgccg aatccgatgc 1805881 ttaggcctgt taataaaaca acaaaagcgt taatatacga cgccattcct tttatatcat 1805941 cttttccttt ttgctgagat aaaatggtta acgtcgcatt gttaaggccc aaaataaaag 1806001 acagcacggt caaaacaatc gtgcttgata ccgcggctgc cccaagggcc tttgccccca 1806061 gtaaattgcc gatccacaag ctgtctataa attgaaagga aacctgcaat gcgtttccga 1806121 gcataatagg cattgaaaac agtacaagct gtttcagcac gttcccctgt gtaaaatcgt 1806181 atgctttcat cttttctcct tgtgttctca aattttcttc ggaccacacg aaaaaagaga 1806241 cgttgtttca tgtctctttt ttcatgactt atcggttttt tttcggtctc gcataccgaa 1806301 tgtaaacacc atcacactta ggaacaaggc acaataggaa acattcaaat acatttgatc 1806361 catatcttca gcagccagat gatgataagc aagccagccg aagtacaggg aaaatgtaaa 1806421 ggataataaa ctgaaatact ggtaaatccg tttcattttc agtcacctct attgtttagg 1806481 atggtaatag gaaaactcaa tttcatcttt ttctaaattt atcttatccg ctttgacata 1806541 cattccattc gttaaaggca tttctgacaa acgcacttca atgcttttat ctccggggtg 1806601 aacatggaca aatgacggca attcataaaa gctgtccata taatttaaca caaagctaat 1806661 tggtatactc aatttcccta acgaaaattt cgtgacattc agctctacat caccgttttt 1806721 tttcacggtc ggctcaaaag cgataaacgc atcaatagac gtggaaaatg ccttgatttt 1806781 ccctgcgaca tgaacatcat catcaatctc tactttataa tcaagcttgt ttgatgcttt 1806841 gtcgtttaaa tatgagttaa caaacgcagc taatgattct tttgtgcttg tcacttgaaa 1806901 tccatactcg ctctcagatg catctttcac ctgagcctgt tcccccggaa gcaaaacaag 1806961 tgccacaaac ccggcggcga ggataaaatt gattgcaagc aatataaaaa acagtcgctt 1807021 ccacttattc atgctgtcac cctactcttt cggtaatcct tcttttttaa tggcttgata 1807081 gacgcgcttt gcgataagag aataacccgt accattagga tgaaaatcat cttcctcaga 1807141 aattcggctg ctgtcacttt tttgattaaa caaatcttcg atatggacga tttttgcatg 1807201 tttatctttt ttcagctctt tttcagcaat atggttccaa tccgtgacga caccatttat 1807261 ttcatttagt tctgataatg taaacgtaaa cggattgtac atgctgacat aaatcagctc 1807321 agcgtgatca ttcagctcgc gaatttcaga aatgattttt tcaaagcgct tttcgtacgg 1807381 tttttccgct tcctgaaacg gttcaacggt taattgcaga aagttttggc gaaggatttt 1807441 catcaaatca ttaccgccaa ttgtaaaaaa gacataatct gcgtccttta tgcctttttg 1807501 aaccttttta tcttttagtt tttctaataa atcatccgaa cggttccctt ttacagcata 1807561 atttttcacg tcgaccgttt tgacttgttt atctgaccgg atagaatccg ccaccttgcc 1807621 gacatatccc tttccgtcgg gatctccgac tccttctgtc agcgaatctc cgacagccgc 1807681 tatgacaatg tgttcttttg ttttcgtttc atgggctttt tgttttccct cagatgatgt 1807741 acgtatgctc gtacacgcag taagaagcaa aatcaaactg gccatgattg aaaaaatgcg 1807801 cagcttcaat cttgttgctc cttcccattc tactagtgga aagtgtatca tgttttagaa 1807861 gatttgcaaa tgcctagtct cttagcttac ttgagtgtac tggctgactt cacatcggaa 1807921 atgatatcat cgtacggtgt attctccact ccattgtaat ctttcagcac cttaccgtcc 1807981 ggacctacca aataaaaaga agattgatga atcacttggt cctctccctc cggcttcttt 1808041 acgatcgctt taaagctctt aagtgcgaac tcctcaatct cactctggct gtatcccgtg 1808101 agaaaatccc agttatcaaa agataatgga taatttgcgg caaatttctt cagctgtttc 1808161 ggcttatcgt tttctggatc aacactaaat gatatgatgc ggacatctat attttcggct 1808221 ttcagttttt tttgcagatc ggtcatatga gcggtcattg gcggacatat agtttcacaa 1808281 ttggtaaaaa taaaatccgc cagccatact tctcctttta aactctctaa agaaacgttc 1808341 ttgccgtctt ggttttgaaa tgtaaaaggc tccacctcgt aattgagcgg atctttaatc 1808401 tgctgtcctc cgcatgcaca caaaaacaga aaaatcagcc cagccgttaa ccccttgata 1808461 accttcatga catccatcct ttccagccag cataaaaacg ctttctaaaa ccgtccttac 1808521 tgtcccatgt ttgtattcga tactgagcaa aaaaaatcct gcatgcctcc ccattaacga 1808581 ttacaaagga gggcatgcag gtaaaaaacg gcatgttacg cgttgtgctt taacacctct 1808641 tgatgaaata cagcctgata atctgcccac ttcatccgcc gcttcatata atgtcggaaa 1808701 gaatacactt ttgccctgct gtttgatgaa aacacttctt ttaagtagaa ttgcaaatgg 1808761 tgatgtaaca taaagaaata gtgctcatct tcctttaata caggtatttc tgtcactttc 1808821 acctgaatcc cgtcaccgcg tttgaactct aggcttttga gtaacaagct atcaatcctc 1808881 ttttttgttt ttcttctatt atatatgatg ccagccgggc tgtctgtcat tttgcgcggt 1808941 tgtgtaaaaa aattagatta gcaaatggaa caagtcctca tccttgttca cctctacata 1809001 atgaaacggt tttttgttca tccgttcaat cagcggccca taatcggctt tgttctgcag 1809061 ctcgatgccg acaagagcag gtccattgct tttattattt ttcttcgtat attcaaacct 1809121 tgtaatgtca tcattcggcc cgaggacttc gtcaagaaat tcgcggagcg cccccgctct 1809181 ttgtggaaaa ttgacgataa aataatgctg aaggccttca aaaatcaagg aacgctcctt 1809241 catttcctgc attcttccga tatcgttatt gcccccgctt accacacaca ccacgttttt 1809301 ccctttaatt tgatccttgt acaaatcaag cgctgcgaca gaaagagctc cagccggttc 1809361 agcaacaacc gcacattcgt tatataattc aagaatggat gtacatactt ttccttcagg 1809421 cacaaggaga atgtcatcaa cgacagtttc cagcgtccgg aaggtttcct cgccaatttt 1809481 tttaacagcc gccccatcta caaacttatc aattttatca agtgtgacga catgcccagc 1809541 tttgtttgat tcaaagtagg atgccgctcc cgccggctca acagcaatta cctttgtatc 1809601 aggagacacg tttttcaaat atgtacctac cccagagaga aggccgccgc ctccgacact 1809661 tgcaaaaaga aaatgcggtt ctgtatcaat gtcgtttaaa atctcgactg cgagcgttcc 1809721 ctgtccggcc atcacatccg gatcatcgaa cggatggata aacgtccgag attccgcctc 1809781 acagcattca gcagcgcttt tatacgcgtc gtcaaacgta tcgcctgtca aaataatatc 1809841 gataaatcct tttccgaata gttcaacttg agatactttt tgtctcggtg tagtagacgg 1809901 cataaaaatt ttcccgtgaa tgccaagatg tttacacgaa aatgccacac cttgagcgtg 1809961 gtttccggca cttgcacaca caactccgtt ctctgtctgc tcgctggaaa gctgtttcat 1810021 tttatgataa gcccctctga gcttaaaaga tctgacaact tgcaagtctt cgcgttttaa 1810081 atagatattg cattcatatc tctcagaaag tctgtcattc ctctgcaaag gtgtgtgaat 1810141 gacaacgtcc tttacgtttt ggtgagcctt caaaatgtct ttcacttgga tgagagagtt 1810201 ttctttaagc aacggtttca tgtacagatt cctttcttgt tttaaatccc tatttaatat 1810261 gccattataa catgaatatt caaaaaataa gacaattatt tttatttaat aattaaaaaa 1810321 atacagacta tgtccaccac atcttgtggt aacttctgtt caaccattat cctgcagagc 1810381 caagaaaaaa gatgatcgta aaataaaggg tgttttcaac caaaaggcat gatataatga 1810441 aaccaattag aaccaaaagg agccaattga tgaatagtgc accaaaactc aatacatttc 1810501 aacatctaat cggagaacat caaacttttc tggaagcgaa gcgaatcgcc aagcagttct 1810561 cgttatcgga gcttcctgtc ttaataacag gaaaaatcgg aacaggcaaa aatcacttcg 1810621 cacatgccat acacttggaa tcttcgagaa gcaatgaacc gtttataagc gtcaattgca 1810681 gcacccattc ggaagaaacc cttattcatg agctttttgg ccctaacgga aacacaggtg 1810741 tttttcaaaa agcggtacga ggaacccttt ttcttgatga tgtatggcgc atgcctgctt 1810801 ctgtacaagc tcagctgtta aaagcgcttg attcagacac ggagaaaccg cgaatgatct 1810861 gtgcttctgc agaccgatcc gtggaacata cattcaggca agacttattc tacagactga 1810921 acattttaac gctcacactg cccgaattat cggaacgaaa aagcgatatt ccgcttttga 1810981 cacagcattt tctctcaaat tctggtcagc aattgttaat cgatccctcc gtttttcccg 1811041 tgcttgagaa gcatgcattt gaaggcaatg tcagggaatt aaaaaacgct gcagattata 1811101 tggcggcagt atcaagcggg ggaacgattc agccatatga cctgccgccg tatattagag 1811161 gcacgataga cggaaaaacg tcgaagaaaa aagcgaaact gcttacttta atggaaaaag 1811221 ctgagttttt gtttattttg gaaacaataa aagtattgaa cgaaaaagga gaacctgcca 1811281 gcagacggat catttctgaa cacagcaaaa atacccaaac ctcgttaact cctcagcagg 1811341 tcagaagccg tctcgactat ttggagaaaa aagattatgt caccaaaagc cgcggacgcg 1811401 caggcacaaa aattaccttt gagggcttga gctttataga gacgttaaaa aatcaaatga 1811461 tctagcgatc gaaaggagaa tgtacttgtt tacaatcaaa gaagagatcg ccaatgcgat 1811521 tacacacggc atcggtgtcc tcttatccat cccagcatta gtgtttctaa tcatatttgc 1811581 ggctaattac gggtctgcat gggacattgt cagctttaca atattcggtg tctctatgct 1811641 gctgttatat ttgagctcca ccctgcttca cagcatcaca cataaaaaaa cgaaggacat 1811701 tttggagatt attgatcata gcgcaattta cgtactcatc gccggaacct acacgccttt 1811761 tttgcttggg ccgctgaaag gcacactcgg ctttaccctg ttggttatcg tatggtcact 1811821 tgccctaggc ggaatcgttt ttaaaatttt ctttgtgaaa cggtttatcc tattgtcaac 1811881 cttcgtgtat ttagtcatgg ggtggctgat gattattgca gttaaacctt tatatgcttc 1811941 actgagcgga gcgggattca gcctcctttt tctcggcggc attttatact ctgtcggaac 1812001 catcttttac atttggaaaa agatcccctt ccatcacgcc atttggcaca gctttgtatt 1812061 gggcgggagc gctgccatgt ttttctgcgt gctcttctat tgtgtaaagg tgcctttcct 1812121 ttcgtaacag taacagaaaa gcgcagtctt cacgactgcg cttttttatg cacgtaattg 1812181 tttttcattg gcaggtatat aagcttttga aaaggacaat tcaatgtctg ccggttttaa 1812241 gcgtttaaaa aacgagccat tttgcatgtt atctgttcct ttcgtttcca ccatcaccaa 1812301 cggaagatga tagcgggccg caagttctac aggatcaata gaaccatcta gtgaaagaat 1812361 caggctttgt cccttttcca gctgttttgt cacatcttca tatacctttt ctgaatcccc 1812421 gtctgaaatc acatccatcc gatccagcca ttgcccgata aaaggcaagc ggaacacttt 1812481 tgggttagcg ataaagccgg ccggttcctc aatatatcca gcaattaagg ccagttcagc 1812541 caaacgcaaa cggggatgca catacaaaac aggaccgtgt ggtattggct ctggctgatg 1812601 gatcgtcaca actgaaccgg agatgccgat acagccttct aaaaacgcct ttggctgttc 1812661 gtacacaaga gccatctgtt ttttgtatga cagacgggga tcgagcattg tttgattaaa 1812721 taattgtttc atatttttta acagcatata cacaatataa accactagaa ggctgtagcg 1812781 aaccaattaa aatcctcccg ctttagaaga attctttttt tcatacatta gaaattcgta 1812841 atcatacggg tttttttcgt ctttggtccc ctgctcagaa gaaaccagct tccaattgga 1812901 ttcatcaaat tcaggaaagt gacggtcacc ctcaaactcg tgatgaattt tcgtcatata 1812961 cagtctgtcc gcataaggga acaggtccgt atagagctga gcccctccga tcacaaagca 1813021 ttcttcaggg cctgaacaaa tgtccagtac atcctttaat gaactgacaa ccgtgcatcc 1813081 ctgaaattct gaatccggcg ctgaggtaac gacaatattt ttccgatttg gaagcggacg 1813141 tccgatcgat tcaaatgttt tccggcccat aatgattgaa tggcccgatg ttattttctt 1813201 aaagtatgca agatcattgg gcaaatgcca cggcaaatca ttgtctttgc cgataagcct 1813261 gttggcatcc atcgcaaaaa tgaatgaaat catacgctga ccgccccttt tatatgagga 1813321 tgcggatcat aatcctcgat gataaagtcc tcaaatgcaa agttaaaaat agaatcaacc 1813381 tttctggcga aacgaagctg cggaagcggt ctaacatctc tttccagctg caaattgact 1813441 tgttcaatat gattttggta aatatgaaca tcaccaaacg tatggatgaa ctcgcccggt 1813501 tcaagcccag tcacatgagc aatgatcatg gttaggaggg cataagatgc aatattaaac 1813561 ggcacaccta agaaaacatc ggcagagcgc tgatacagct gacaggacag cttgccgtca 1813621 gacacataga attggaacag gcaatggcac ggcggcaacg ccattttatc aatttcacca 1813681 acattccagg cgctgacgat taagcgtctg gagttcggat ttgttttaat atcttcaata 1813741 agacgggaaa tttgatcaat ggtttctcca tcagctcccc gccaagaacg ccattgggag 1813801 ccatatacag gtccaagttc accgttttca tcagcccact cattccagat tcgcactccg 1813861 ttttcctgca gatagcgtac attcgtatct ccttttaaga accacagcag ttcatgcgca 1813921 attgatttaa agtggagttt tttagtggtg agcatcggaa agccttcccg taaattaaat 1813981 ctcatttgat atccgaaagt gctgattgtt ccggtcccag tccggtctcc ctttttctca 1814041 ccatgctcta aaacatgtct gcagaaatcc ttatactgtt tcattttttt catcctttaa 1814101 aagtagtctt ctagtagtgt aacacaataa aaaatcattt ctgaacccag aaatgatttt 1814161 tttatagtca gctgacgaca ggcttttcat cctgttcttt ttcttcatct tgcagatcct 1814221 gatgcgtatg tgcaattctg ctcgccgctg ctgcagcaag agctgccaca atatcatcca 1814281 aaaaggtgtg aataccgtct ggactttcat caagttcctt aataattcca atcttctctt 1814341 tatccaaata accgaaattg gtcaaaccga tcgacccgta cacattaacg attgaaagcg 1814401 ggataatttc atctatgccg taaagcggtt catccgtttc aacaaggtgc tgcagcggtt 1814461 cggggagaag tttctgttct gcaagctgat cgagtgcaag gcctgtcaaa acagcatgaa 1814521 taatttcacg tttgttcagg actttttcta cattctccat gcaaacactg agcggcagat 1814581 ttggattgta tttttcctga agtttttgaa caatccgtgc aatatcttct atcataacgc 1814641 cccgtttgtt cagcatatcc tttgttatat cgaccatttc attcattgtg tactttttca 1814701 tgtctaatgg catctccttt aggcactcat ccagttggga ggcgtgttgc ggtcccagta 1814761 aatgctccca agctcatgat gtgattgaaa tccatcttct gctgtatgat aatgaaaatt 1814821 aaaccagtag ccgtcatgag gcgggtggtc tcttcgcaca tggaatctga gaagatcttc 1814881 tccagttgtc cgattgtaaa cgttgaaaat tttttccgtt ttgcccgctg aaggcatgct 1814941 tgagatcaca acatcttggt acgcctcatc atcttgcaat gtcgctaaat aatcactaat 1815001 cacattttcg atttttggca ggatctcttt ccgatagtca tcctcaatga caggagcgat 1815061 tctgctgccg aattttaaaa aggactgatc ctcagcgctg tcaaggagct gttccttgta 1815121 cgattgaaaa agcagttcag gatctcgcct gtcatccgac tcatcatcgt acaggtcatg 1815181 ctcatcataa aaagcggtgt aatcattctg ctcaagactg ctcggctgtc cggaaggctt 1815241 gtccgccata agggcagccg gaggagatac gagcccgaac gttacaatgg taaataaaac 1815301 cacaagggtc tttctcatcc acaatttcat gactgcttat tcctctctat tttattgtca 1815361 tgtttctctt attttagcac atccaaaaca tgcaagtcat gtactatatg aaactgatat 1815421 gcaaattagg agattcgttg ctatgcactt tgtgtaaaaa cgcttacaat atttcatgaa 1815481 aggaggcttt ccgcatgatt gacgctctgt ttgccacagt ttcactctta acattattat 1815541 actttgtcgt catggaggtc accgattaac agaaagcccg tgatatgaat cacgggcttg 1815601 tttgaatgac gccataatgg aacagtgctg tttttctttt catgacgtta aaaccaaact 1815661 gttcaaaccg cgggcttttc cagtggtctt ttagcacaac gctttttctg gcgactcgta 1815721 ccgcttcatt gatacatcct tcgtgcaaaa cggaatcctc tgccaaatca cgtaaaggcg 1815781 cgatgccgtc agaggtttct acaggttcat gaaacattgg atcgaaataa accacatcaa 1815841 cagagttgtc agggagctgc ttgatgtgtt caaagcaatc accattcttc acctggattc 1815901 ttctcatcgc agcttgaagc tcttctatac ccgtttccca tgaatgcagc cccgtcctca 1815961 ctaaaacaga cacaagatgg tttttttcaa tcccaacaac agaacccgtt tcgcctactg 1816021 ccatacttgc gataatggca tctgacccca acccgagtgt gcaatctaaa aacgtatccc 1816081 cttcagataa gccggcagcc cgaagcatag gttctttctc cccctgtaag aagcgtttgg 1816141 ctctgaacat cgctgtattc ggatgaaaaa agaatttggc accttgtttc gtatacagct 1816201 caaaccgctc tttgccgacc acaagcaaat cacgttcagc tgatttcagc aggtgctcaa 1816261 ccgtttgttt attccggccg cagtatggca tatttagctc tttagaaagc tgctttgcag 1816321 tttttatggt gtgttcagac ggtctatagc ttgttgttat catcttctgt actcccaaaa 1816381 agaaaatgcc cggagaacgg gcatttagca gtgcgcatcg aaggcagcag tcagattttt 1816441 catgatttct tccatatcgt gtccttcaat ttcatgacgc ggaataaaat gtacgacttc 1816501 tttgcctttc aaaagagcca ttgatggtga agaaggctcc tggccagtaa aatactcacg 1816561 cattttcgca gtagcttctt tatcttggcc cgcaaataca gtcaccgtat tgtcaggtgt 1816621 tttgtcattc tggaggactg cctgtgtagc cgcaggacgc gcaaggcctg ccgcgcagcc 1816681 gcatacagag ttaacgacta caagagttgt gccctctgcc ttttccataa agttttctac 1816741 ttcttccgct gttgttaact cttcaaaacc tgctccagtc agctcgcggc gcatcggtac 1816801 gacaagctgg cgcatgtatt cttcataagc cattgacata aaaaaagccc cctctagtat 1816861 ccttcatctg aagtaaagga tactatagag agggccggat ttcaaatgtt cacgccttaa 1816921 aataaaagaa agtgtcccca gctatctaga ttttcataat accgccggtg ttggcacttg 1816981 tcacaagttt agaataacgt gccaggtagc cggttttcac tttcggttca aaacctttcc 1817041 agttcgcttt tcgtttttcc cactcttctt ctggcacttg tacatccaag atgcgttttt 1817101 caatatcaac gataatatgg tctccgtttt caacaaaggc aagcggcccg ccctcagcgg 1817161 cctcaggtga tacgtggccg attgagaggc cacgggaggc tccggaaaaa cgtccgtccg 1817221 taatcaatgc cacttttggc ccgagtccca ttccaacgat ttgggatgtt ggcgccagca 1817281 tttccggcat gccaggtccg ccttttggcc cttcgtatct gatgatgaca acgtcgcctt 1817341 cttttacttt tcggttgata atgccgtcaa gcgcctcgtc ctgagaatcg aatacgacag 1817401 ccggcccttc gtgtcttgta atcccattct gtacgccgcc tgttttaatg atagcgccgt 1817461 ccggagctag attaccgaat aaaacagcaa ggcctccctt ttcagtgaat ggttgatcca 1817521 gcgggtgaat gacgtcataa tcctttactt catgtccggc aatggtttct ccaagagttt 1817581 ttcctgtaac agtcagcgca tctaaatgaa gcgctccttc tttcttcgaa agctcattca 1817641 gagccgctga aacgccgccc gcttcgtgaa gatcttcaat aaacacatcc gatgcaggcg 1817701 ccagcttagc caagtgcggc acgcgctcag cgacttcgtt aatgcgttct aaagagtatt 1817761 caacgccggc ttcgtttgca agggcaaggg tatgaagaac ggtatttgta gaacctccga 1817821 gcgccatatc gagtgcaaac gcgttatcaa tcgcttttac tgtaacaata tcacgcggtt 1817881 tgatatcttt gcgaatcgtt tccattaatt gcgcagccga ttttctcaca aactctttgc 1817941 gttccggaga tgttgccaga atggttccat tacccggcaa agcaagacca agtgcttctg 1818001 acagacagtt cattgagttc gccgtaaaca tgcctgagca agacccgcac gttgggcatc 1818061 cgaactgctc tagttcttga agctcgtttt cgttgatttt ccctgcttgg taggcgccta 1818121 ccccttcgaa tactgaggaa agggagattt ttcgcccgtc acttgttctt cctgccgcca 1818181 tcggtccgcc gctgacaaaa atcgtcggaa tgttgatgcg cattgccgcc ataagcattc 1818241 ccggtgtgat tttgtcgcag ttcggaatac agaccattcc gtcaaaccag tgtgcggata 1818301 caaccgtttc cacagagtct gcgataattt cacggcttgg cagcgaatat ctcataccga 1818361 tatgccccat tgcgatgcca tcatctaccc caatggtatt aaattcaaac ggaacgcccc 1818421 ctgcttctct gattgcttct tttacgattt tcccaaactc ctgcaagtga acatgaccgg 1818481 gaacgatatc aatgtatgaa ttacacaccg caataaacgg cttgccgaaa tcctcttctt 1818541 ttacccctgc tgcacgaagc aaactgcggt gcggagctct atcgattcct tgtgtgatca 1818601 tattactgcg taattctgcc atggtgatcc tcctaaattc tttcaattgt ttgattggat 1818661 tttattttga caattttcag tttatttatg ggctgttttt gcaaataaga taaatacagg 1818721 ccgccctcac cttgttttgt tctttcgtgt ttttatattt atatagcttt ctttcgattt 1818781 gaaccctcca actattaata ttgttactta ctataaatag ttttcggata tttttcaaca 1818841 atattcgaaa taatttttat aaaaagtgaa ttcacataaa aaaggtgcat gatctgcacc 1818901 ttttttatct ttattcgcct ttttttctgc tttccgtcat ttgtttccaa acagaacctt 1818961 ttgcttcttc tccatgctca atacgttcaa gcgccatttt gacttgaagg ctgacctcaa 1819021 attcggggtc atcttcggca gcgcgcaaag cttcaattgc actttcatcg ccgacttcgt 1819081 acaggaacat ggcggcacgc cagcgaacaa gcttgctgga gtcgcttaat gacttgatca 1819141 tagcaggaat ggcttgagga tcgccgatat cagacaggca gtctccggcc gttcttctga 1819201 ctgatacagc tttgtcctca agtgctttat acaatagagg aagaacatca ggtgtttcaa 1819261 tcattcctaa gtacacaaca gcctgtcttc tgatggacac ctttggatca tccaatgcct 1819321 tctgtaaaac cgggatatcc tcttctttcg gatccatctg ttccaagtgt gcataacgct 1819381 ttttccagtc ctcatcatcc agcatatcaa gcgttacttt atacgctttg cgctgtacag 1819441 cttgttttgc ttcgcccttt ccttgagcgg ctgcttcagt cagtcgtttc agccgttcat 1819501 cactgtatgc cgcttgaagc tcttctgtca catcatggcc gatttcatca aagtcaccga 1819561 atctgacacc ttgttctttc caagcccgct caaacacaac attggaagct tcagatctaa 1819621 gttttaagat cgcctgctga aagcgttcag gtaagccgaa gcgttcttcc cgctctccat 1819681 cggttaattt aacttgcata ggaatgccgc tgaacatctg cacaaaaact tttacctctc 1819741 caaaagattc ttgatcagaa cgattttctt ctgcgctttc agcactttcc atcccaaatg 1819801 cagtgcggac ttgcggtaaa atgtctttcc agtcgtatct tgcattccgt tcaacagcaa 1819861 gaaaatctgc gacgtgatat acccctttaa ctccatctat tttaaggatt tccgctataa 1819921 caagcggtgc gccttctgct tgctcaggtt tatagttatt gcttttgccc gccggaagct 1819981 cttccgttaa gatgactttc attgtattcg ggcttggtgt aggttcaatt gattttatct 1820041 tcatgatcgt cctcctatag catatctgtg acttattcta tcatagtcgc tccaagcctt 1820101 ctattacgac gtttcggcat caatcccggg tatgtctttt tctaattggc ggacaaattg 1820161 aagcataaaa ttgtgtcttt cttctgccag ttcccgtgca gtgtctgtat tcatcatatc 1820221 tttcagccgc agcagcttat gaaaaaaatg agcgtaggcg ctttgctcat ctccataaag 1820281 gccatgccct tttgcgcccg caaacatgaa agctctcgca atgccgacag caccaatcgc 1820341 atcaagtctg tcagcatcct gtacagcttt tccttcaatt gagagcggct ccttcgccaa 1820401 tttccccctg tcccgaaagg acatccttgt tataatatga atcaccctgt cagcattctc 1820461 ttttcctact ccgaaaaaaa cgagctgatc atatacttcg ctcacagaaa gcctgaccgt 1820521 gtcaggcagc ttcacatcaa ttaaatcatg aaccaaagcc gccgtttcaa caatgaacaa 1820581 atccgctttt tccttttctc caatatacgc tgcaagatct gctactcttg atacatgatg 1820641 ccagtcatgt ccagagcttt cgtcagtcag gatagattga acccatgtcc tgatttgctc 1820701 tgcctgcttc aattccttca caaaaacacc ctctttttat tgctctaata gcttcacgat 1820761 atcgtcttcc aactctttcg gatttgtatt tggtgaataa cggccaacga tttctccatt 1820821 tctatccact ataaatttcg tgaaattcca cttgatcgcc ttagttccca gcatcccttt 1820881 cgcatgttct gtcaaataca caaacagcgg gtgggcgttt ttcccgttta catccacttt 1820941 tgaaaacata ggaaatgtaa caccgtaatt tgtttcacaa aattcctgta tgtcagcctc 1821001 ttcaccaggc tcttggttca tgaattgatt gcaggggaac cctaagatct ccagcccctc 1821061 ctgctgatat gtatcatata attcctgcag ctgcttcaat tgggaagtaa aaccgcactt 1821121 acttgctgta ttcacgatca tcagtacctt tcccgcgaaa ggctgaagtg tcatgtcttt 1821181 ccctgtgatt gtacgtacct tcatatgata aatagacatg taagtccctc ctatgtcctt 1821241 ggtgctgatt attttacctt ttttaaatcg caattcaaaa tgtaaacatc aattaagaac 1821301 tcataagaaa cctaacgata tgagcgtcag ttcattatca attcatatgg ctcgtttttt 1821361 atcttatcat tctataaaac attacaattc cctcttacat ctttgaaaat cattttactg 1821421 tgaaaccaaa aggcgtgtca gtgcgtttta tttaaagagt tttctgttgt ttccccctca 1821481 acacgtatag atagattgaa aattggcgtg aaaattccta taatgaagaa aattaaacgg 1821541 ggaaataatg gaggtggcac gttgcctatt aatataccaa cacacctgcc ggcaaaacag 1821601 gtgcttgaaa gtgaacatat atttgtaatg gatgaaagca gagcatttca tcaggatatc 1821661 cggccgcaaa aaattattat attaaatttg atgccgaaaa aaatccaaac agagactcag 1821721 cttctcagat tgcttggaaa ttcgccttta caggttcatt tcacattttt aatcccaagc 1821781 acacacacgc cgaaaaatac tgcgagagaa caccttgacg aattttacac gactttttcc 1821841 aatatccgtc acaagaggtt tgacggcatg attatcaccg gtgcgccgat cgagcatttg 1821901 gcgtttgaag aggtttcata ttgggaagag ctcaaggaaa tcatggagtg gagcaaaaca 1821961 aatgtcactt caaccttgca tatttgctgg ggtgctcaag caggtttgta ttaccattac 1822021 ggtgtggaaa aaattcaaat gccgaaaaaa atcttcggtg tgttcgaaca taccgttctt 1822081 tcaaaacacg aaagattggt aagaggtttt gacgagctat actacgtgcc gcattcccgg 1822141 catacagata taaatatgga acagcttcaa gcagtgcccg agttaaacat tcttaccgca 1822201 tcaaaggaag ccggggtttg cttaattgtg tctaaagacg aaaaacaagt ctttttgaca 1822261 gggcaccctg aatatgatac aaatacgctt cttcaagagt atgaaagaga tttggaacga 1822321 aacctttcta ctgtcgaggc ccctaaacat tattttgcaa aaggcagcaa cgagccagtg 1822381 aatcgctgga aagcgcatgc cacattattg tttatgaatt ggctgaatta ttacgtttac 1822441 caagaaactc cttatgaatg ggactaattt ttcttttttt agtgatacgc tgagcaaaaa 1822501 atatgataaa atacatctga ttcagtctgc gtataacaaa aatttaaaat actggaatcc 1822561 aaatcattta aaattagctt aactttttca ctgcattaat aattcgatta tgtatttgtg 1822621 ttatgtttat gtatagacaa taactcctta cgatgcatga agcttgcttg ttgttgatta 1822681 cattgaggtg aatttacttg aataccaata aaagagtatt aattttgact gcaaattacg 1822741 gaaatggaca tgtgcaggta gccaaaacac tttatgaaca atgtgtacgg ctcggctttc 1822801 agcatgtaac agtttctaat ttgtaccaag agtcaaatcc gattgtttca gaggtaactc 1822861 aataccttta tttaaaaagc ttctcaatcg ggaaacagtt ttatcgtttg ttttattacg 1822921 gagttgacaa aatctataat aaacgtaaat tcaatattta ctttaaaatg ggtaataaaa 1822981 gattgggcga acttgtcgat gaacatcagc ccgatattat tattaataca tttccgatga 1823041 tcgtcgtgcc ggaatacaga cgccgaactg gaagagtcat tcctaccttc aacgttatga 1823101 ctgatttttg tcttcataaa atttgggttc acgaaaacgt ggataaatat tatgtggcga 1823161 cagattacgt gaaggaaaaa ctgctggaga tcggcactca tccaagcaat gtaaaaatca 1823221 caggaattcc aatcaggccg caatttgaag aatccatgcc tgttggcccg atatataaaa 1823281 agtacaatct ttcaccaaac aaaaaagtgc ttctgatcat ggcaggtgct cacggtgtat 1823341 taaagaacgt aaaagagctg tgcgaaaacc ttgtcaagga tgaccaagtg caagtagttg 1823401 tcgtgtgcgg gaaaaatacg gctttaaaag aatctttgag tgcgcttgaa gcggaaaatg 1823461 gtgacaaatt aaaagttctg ggctatgtgg agcgcattga tgagctattt cggatcacag 1823521 attgcatgat taccaagccc ggcggcatta ctttgacaga agccacagcc attggagtgc 1823581 ctgtcattct gtacaaaccc gtgcctggcc aggaaaaaga aaatgcaaac ttctttgaag 1823641 accgcggagc tgccatcgtt gtgaaccgtc atgaagagat tctcgagtca gtcacttccc 1823701 ttcttgcaga tgaagatacc ttgcatcgca tgaagaaaaa cattaaggac cttcatttag 1823761 caaactcctc tgaagtgatt ttagaggata tcctgaagga atcagaaatg atgaccgcca 1823821 aacaaaaagc caaagtgcta tcgtaatggc gtacttgaga gcatacgaaa atcgtgtgct 1823881 ctttttattt atattcagcc atcaataaaa gcggttacat ttttttatgg aacttgccct 1823941 tcttttgaaa aataagccgt ttcgcaactt gacgggtgct cccagatggt gtatagttga 1824001 accatcattt aacaatgaat caaagttaga tgatgacaaa atttttttta gcacatgggt 1824061 gctacagtac taggaggaat taagcaatat gcaaaacggt aaagtaaaat ggttcaacaa 1824121 cgaaaaagga ttcggcttca ttgaagttga aggcggagac gatgtatttg ttcacttcac 1824181 agctatcgaa ggagatggat acaaatcatt agaagaagga caagaagttt cttttgaaat 1824241 tgtcgaaggt aatcgtggac ctcaagcttc taatgttgta aaactctaaa ctcaatacat 1824301 gatgatgaga tgacaaatag aggagaggca ttcgcctctc ctatttgatt ttcatctgga 1824361 tttcaatcgc caaaatgttt tgtttacacc tctgttcaat ctcttcaaca tacttttcca 1824421 ttgatggttt tccttttttc gcgatatcgg ccagttcttc taaatcactg tatatttcta 1824481 taaatgtttt gtgaaggatc aacttcaagt ctttatcatc catagctgcg ttccccttct 1824541 ctatcaagat acctcaaata gtaaaacggt cctatttatt ctggttcaat agttatatcg 1824601 gcttattttt attttctttt ctattttggt acataaattt caaaaaaact ctgcaaaata 1824661 atggcggagg tgttttttgt gacttcagaa tttcataatg aggatcagac cggctttacg 1824721 gataagcggc agctggaact agcggtggaa acagcgcaga aaacaacagg agccgcgacg 1824781 agaggccaaa gcaaaacatt agtcgactct gcataccaag ccattgagga tgctagagaa 1824841 ctgtcacaat ctgaagagct ggcagctctc gatgatcctg aatttgtaaa gcagcaacag 1824901 cagctgctag atgacagcga gcatcagctg gatgaattca aagaataaaa accgcagctt 1824961 ctgcggtttt tatttttagt gattggttaa gacatctccg tattgtttca acttttcacc 1825021 aaccgtacat ttattgatac aaaatgaatg cgcataagtt ttgccaaatt ctttgcgaaa 1825081 ctgcttctta ataaaacagt ccttgcaata ttcatcgtgc agttctgtca gttctttaaa 1825141 gatcattttc ttatccaata tcgtcatctc cgttacggtc taatttcgtg tggctttcta 1825201 cgaattgatg ggatagaatt tttttagcga ggccgtcagc ttcctgattg tcttttcgtt 1825261 gtattgtttc gtaggttgga gtaagcttca gcgattcaag gagtgcttct attttgtcca 1825321 gccattcatt atgagatgga tcataacaag gccagctgcc gtcaagctga ttcagcacaa 1825381 caagcgagtc ccctttgatt gtaattgaat ttctgcttgc cccaagctct cttacttctc 1825441 ttattgcttc ataaagcgct gcgtattcag cttcattatt ggttttcagc cggaagcttt 1825501 tattttttct caagcgatgc cgggttcctc ccaatgaata atagatgacg atcccgagac 1825561 cggccagttc gctctcttta tcgaaactgc cgtcaaaata aacagtaatg tcatcaggct 1825621 cttgagcaag ctcctctgtc agcttttcca attccttcag cgtccagctg ccgcctttct 1825681 cgtcttcgaa ctctagctcc ttcatgtatg gaaaacggcc aagttctctg gcgaacgtac 1825741 gtgcctgctg tgctgtcagc cagtcttcgc taaaaaatga gacggatccc gttccttttg 1825801 cttctatttt caaatgcggt ctgagcttca ttacaatcac cttaccattc attagttgcc 1825861 gggcttatgc tataatcaaa ccaatcttac cccggaaagg aagctttttc atcttgttta 1825921 ataattcgtt ttggatcttt tttgcgatca ttcattttat cattgttctt ttattttata 1825981 aaggatttgg caaaatggga ctgtttgttt ggatcggttt tgcgacagtc tgcgccaacc 1826041 tccaagtcgt caaaacagtc gaactgtttg gcttaacagc gacactcggg aatgtgatgt 1826101 atggcacaat cttttttgcg acagatgtgc tgaatgaaaa atacggacca gctgaagcca 1826161 gaaaagcggt atggctcgga ttctcaacgc tcctgacgct gacatttgtc atgcagggcg 1826221 tgctgctttt cgaaccggct tccagcgaca tatcacaaac agcgctggaa acgatcttcg 1826281 gattccttcc gcgagttgcg ttaggaagtc tgcttgcctt tatcttcagc caaacgctgg 1826341 atgtttatgt atattcggca attagaagga tatttccttc tgatcggctt ttatggctca 1826401 gaaacggcgg cagtacagca gtcagccagt tgtttgatac attcatattc actgcagtcg 1826461 cctttctcgg catttatccg gcagacgtgt ggcttcatat ttttatttct acatatttga 1826521 ttaagtttgc ggtatcttta atttcattgc cttatgccta tgcagccaaa aaaatgatac 1826581 ctaatgatga aaggagttca taatgcctac agaaatatat gtagacggcg caagcgccgg 1826641 taatccaggg ccttccggta tcggcatttt tatcaaacat gagggaaaag cagaatcttt 1826701 ctctattcca atcggagtgc atacaaacca ggaagcggaa tttcttgcat taattgaagg 1826761 gatgaagcta tgtgcaacgc gcgggtatca atcagtttcc tttcgaaccg attcagatat 1826821 tgtggaacgc gccactgagc ttgaaatggt taaaaatata acgtttcaac cgtttgtaga 1826881 agagatcatc cgattaaaag cggcattccc tctttttttc atcaaatgga taccgggcaa 1826941 gcaaaaccaa aaagccgatc ttctggcaaa agaagcgatt cggctgaatg aaaagaatta 1827001 aatcttgatc attggttcat cctaatggcg aggtgaacta acatgaaaaa gaaagataaa 1827061 ggccggctga ccggcggtgt tactccgcaa ggcgacctgg aaggcaatac acataatgac 1827121 cctaaaacag agcttgagga gagagcaaaa aaaagcaata caaaacgcta gagaggatct 1827181 aaacgatctc tctagcgttc agcttttcaa gcatacgctc aattccttta atttggtggc 1827241 ggcgaagcat gtcagccgcc tgctccattt gcaaagtaaa taaagcgtct ttcagtgtgc 1827301 aggccagcgg cactgagcaa tggatttccg caagcttcct cgacatctcc aaatcgctta 1827361 aaccttgctg aatttttccc tgctgtcctt ttggaagaag agaaagattt tccaataaac 1827421 ggtcaatcgt ttcgtattca cgaatcagtt tgtaggctgt tttttctcca atgcctttga 1827481 ctccgggata gttatcactg gaatcaccca taagcgcttt aatatcaatc aaagccttcg 1827541 gcattacgcc tgtttcttca taaaaagtct cttttgtata gactttataa tttccgattc 1827601 ctttttgaag caaagcaacg cttactttat ccgttaacag ctgaagtaaa tctctgtccc 1827661 ctgttaccac cgtaatgtcc gcttcattcg caaataaatc ggcaagagta ccgatacagt 1827721 catccgcttc atagccggca aagccaatat tcatgattcc aagctctgcg gctgcttcct 1827781 ttgccaaatc aaactgcgga atcagctcca caggcggcgc gctgcggttg gccttataat 1827841 cttggaacaa gtcatttcgg tacgttttgc tccccatgtc ccagcagcag acgacgtgtg 1827901 tcggctggaa tgtttccaca gctgtaatca aatgctttaa aaagccgttg acgccgttcg 1827961 tcggcacccc gctgtcattt atcataaagt tgcgatgtac ggccgtggca aaaaaggccc 1828021 ggaataaaag agccatgccg tcaaccagca atagtttatt attattcatc aaataactcc 1828081 cttttctttc attccttcta ttttatcata aagcagccca aaaataaaaa acagtatctc 1828141 tttaattaga gatactgttt gaatatttat caatcgttgt gtcttttgtt gctggcgatc 1828201 agcttttcag cttcgcgtcc tgcgtaagag tcaaaatggg tttgaaatcc gtttttcttt 1828261 ttggcgttgt tattcgcctg tgcatttctg tttccgagct ttgttctgcc caacatgaat 1828321 ccccccttac gtcggatgca tatagtatat gcttccggca ggaggttcac tcgcgacagg 1828381 atcatccagc ttacatgcgg cttacgtatt ctctgaccat ttcttttgat acaagccgtc 1828441 ttgtcgggac gatgcctttt ttagcgagct gattcatttg ctcggtaatt tcattaattg 1828501 catctgtagt ataaggctca tcgtttctgc atttagcaac agcttcttca atcgccaatt 1828561 cacgcatatt ttcaagacgc ataaatgctt tgatatgctc gtgctgtttt gatgaatgtg 1828621 ctgaaattgc tttatgtacc tctgacatta atcgttcatc tcgctttttt ctatttagtc 1828681 tatcatgact tgaaatacaa gccaactgaa ttttacattt ttattgtatt gtctgaattt 1828741 ttccaggaga tgcacgcctg atacgccatt tcaatctctt tcgcatgttc cccttccgca 1828801 tatcctctta aatatgtctc tttttgatcc gttatttgcg cgattgcttt ttcacccata 1828861 tcttcctgta agcgtctgag gtgagcagtg taatgagata tcaggctttc ttcttcattt 1828921 tttatccatg cctctgtgat tttcgtaagt ttcatccgta cagcttcgat aaaggtcgct 1828981 tttcctttct gctcaaaaaa ctgcttcggt gatttgatct cttttagttc ctgctcaaaa 1829041 gcacgttctt ctatttccgg ttcaacttcc ttcaactgta tgccgttcga atgctgatca 1829101 cccgcataaa cggaaaaata accgtcctcg tttaatgttt tttgaaaatg atccagccat 1829161 tcttcattga tatgccgttc gatgaaaccg ctcatgcgaa catcaagcgt tttgatttcc 1829221 tgaatatatt caaatagata ttcatgtaag gctgttgtca tcgctttact gacgttcttt 1829281 ttccaatccc cgttttgcag cccgggatga aatgccgatt ttaataaatc atttgcaaaa 1829341 tatgataatc gctgtgcaat gtgatatagc tgctctcttg tatctttttt tactttttca 1829401 atgatggttt ttgagttccg ccgtttctcg atatcggccg ctgtccgctc aaatgacagc 1829461 ataaggcact gtttctgcgc ttccttctct tctcgggact gatgctggga ttggtgaagc 1829521 tgaaaaacag tttcgcatag tttgtctgcc tccgaactga gctgcgctgc tgacgctttt 1829581 tttacatcca cttcgataaa ccggtctaag tgttttctta ctttcgagaa ctgattataa 1829641 aatgactccg gttttcccac cagttcctcc ttacttgata cggtaaagag ctgcggctca 1829701 taaacccctt cttttacaag ctctgcgctg acataatcgg tcactgtttc gagctctgtt 1829761 ttatcttttg caaggtctgc agcattaata ataaaaaaca ttttatccat gctgagcgat 1829821 tctttcacaa gtccaagctt tcgcaaaaat gaacggtctc cttttgaaaa agagtgctga 1829881 taataagtca tataaaaaaa tgcatcagca tctttgatat attggaatgc cagttctgta 1829941 tgccgtttat tcatgctgct cgcgccgggt gtatcaacga tcgtaatccc tttttcagtg 1830001 agcgggcatg tatagtagac cgttacctct ttcacagcac aggccgttgt ttcctctgct 1830061 acatacggct ttaattcaga gagcggaatc gttaatttct tctgttcctg tatatactgc 1830121 tgatacttct cgtatgcaag caggaaattg ctgatcaatt tcacgtgttc ttcctgcagc 1830181 ctgttttttt tgactgcctt ttcccacttc tctgtgaagg aacggcctgc cggctccttt 1830241 ggtattccgg tgagctgcaa aatttcagcc gttaagtcat cctctgtctt aaacactaca 1830301 ttcgctgttt tgtttaagtt gccattgatt ggctttgtga tcttgttaat tgtcgctgtg 1830361 gttggcgttg gtgaggatgg cagcactctt tcgccgacaa gcgcattggc aaatgatgat 1830421 ttccccgagc taaagcctcc aaaaagagcg agtgtaaatt tccgttcctc aagccttttc 1830481 accctttcac gaaacgctga agtttgcttt aacaacatgc tgcattcgcc taaaatgtca 1830541 gacaaagtgt aaaagcgttt gatttggtct tgaagcggca tttcttgttc cattttgatt 1830601 tctgatttcg gcatcggctg cgccgtcagc tggcttcggc cttgtttctg ctctggagcc 1830661 gccactcttg ttttcttcga tttaaaccat tctgtgtcta tatgcattgg gcatgcggac 1830721 tcttcttccc aaatggccca caggcgatcg gttttctctc gggcattatt ctctaaacgt 1830781 gcctgttctt gaagaaagac aagtttttct gattcttgga cgagccggtc gttaattgtt 1830841 tgcacatctt tggaaacacg ctctttcacc atagcggaga gcacctttat gatgtctgcg 1830901 gcttctcttt tcgcctcttt ccggatgagc tctgccaagt cttttgtata ttgcaataca 1830961 tattcagagg aaaaggctgc accatgcttg accgcgtgtt caatgatgct tatatcaagc 1831021 ggtgtgcgat aggcctgaat cagcttttca ctttcagcgg tatagacatc aaataccttg 1831081 gcgagtttat gaagcgtgtc tatcatatgc caatccgctt cggcctctgt tcgttttgcc 1831141 acatcagaga aaaaagcatt ccgcctttta tctctttcct gtgcagtttt cgctttagaa 1831201 aagaaaaagc cggttttaaa ggaaggctct tgtgattcta aaaatgcagc cgccaattca 1831261 cgcatttcaa aaggcgtcag gttggcgttt tttaaaatac gattgatttc ttcctgcatc 1831321 ctcttctctg cctcagtcat ttgtttttcg gcctcatcca attgatcacg cagcgattgg 1831381 accagtccag tatggatatt aagctgttca gcgaaactcg gagcgcctgt ttcgtctttc 1831441 ttcagcattt ccgtatgttc ctttagcaga ttacggactt tttgttcggt taaagcctgc 1831501 atattgcttt ttgattgctg ttctattctg cttaactctt ctctcagggc ccccatctga 1831561 ttgaacgggt gatccggttc tgttactgat gtaaaataga gcgcttccct tgaaatccct 1831621 tcattgcaaa gcatctcctc tacctgcgct tgatagtctc caaatttcgt ctccgtctca 1831681 tcatggcggt caatttgatt gacgataaaa tacacattcg gaatgctttc ttttattgat 1831741 ctgagaaact ttacattttc ctcagcgtgc acgtgattat agtgaacgac gtaaaacagc 1831801 gcatccgctt ggtgaagaat agaagcagcc gatagaaaat gcgcatcatc tgttgaatct 1831861 atccctggag tatcaatata cgcaaccccg gaatcgatct cagtatacct gtcaaaaatt 1831921 tcgacgcttt caatctgttc cccgtcttta caatattgct gcaccttgtc tttctggtaa 1831981 gtcccttcca gctcagcaca cgctccgtct gttgtatgaa gccgaactcg cttttccccg 1832041 tttctgatca caacaaggtt agcgcttgtc ggaatcgggc ttgtcggcaa aatattctcc 1832101 attaacaggc agttcagcag tgacgatttc cccgctgaat aatgcccggt aaacgcgata 1832161 taaacctctt catcagccgc ttttttcatg accgcagcca gtttagcagc cctttgttca 1832221 tcttgattct caataaattg cttataaagt tccccggttt tatgcaaaag ctcttttctg 1832281 ttttgatctg tcataagtct gaaccccttt gtgccgtttc aattgtgaac ctttttcgaa 1832341 agatctgaat tcattccctt ttcattttac acaagaataa accaaatttc tttaggagaa 1832401 tagaaaaaag ccgccattac ggcagcttct ataaaagaaa atctgcaact tttacaagtt 1832461 ccagattcat caaacagatt tattagagat tccttttaat acaaaaccaa ttaatacact 1832521 atatgtacaa accgctccaa gcaaaaacag cattgtcatt tgcttcacca tcctgattga 1832581 gaatcttttt caaacccatt ttaacatggt tgagaatgat tttcaatcgc tattttacgc 1832641 tgtattcctg taatgctttg tcttctgcgc gaattctgac gcttaacaac acggcattga 1832701 aaatggaaaa cagacacatg gtgacgtatg cttgataaag cagcggaatc agcaaaattt 1832761 cgaggataac aacggcatag tttggatgtt tcatccattt atatggacct ttttttacaa 1832821 gctctacacc tggaacaaca aggattttcg tattccaata tgctcctaag gaacaaagcg 1832881 cccaataccg tacgatctgt acgcttaaaa tcactgcagc gataccgagc caccagctgg 1832941 acggctgttt attcatcagc agcacctcgg caattaagga caggaaaaaa aggatatgca 1833001 tcgtaatgat atacggatag tggctctcgc caaattcaat tgctccttgc ttctttacct 1833061 tttgttcgtt ttgcctggcc actgccattt ctgctgctct ttgaacaatg agaatggcga 1833121 tcaacaacca aaacatgagt caggccccct tttcccagct gaataatagc aactctgatg 1833181 agaaacccgg ccctaatgcg ccaatcagtc ctcgttcagc ttccttttta tgtccgttct 1833241 gcagatggtc tttgatcaca tacaagattg tggctgaaga catatttccg tgcttttgca 1833301 aaatgctttg cgcagatgaa agcttttctg acgacagccc gagacttttg atgtatgcat 1833361 cgatcacttt ttttccgcct ggatgcgcca aaaaaacact gatatcatgg aatgacagct 1833421 tatgtttgtc caaaaaaatc tgtacatttg ttttgagcca tttttccacc aaggtcggaa 1833481 tgtctcgtga gaaaatgact ttgaatcctt gatcggtaaa gtcccagccc atgacatctt 1833541 ctgattgttt catcaaaaca gattgggcgt ccattatctt cggcgcaagc ttcagctttg 1833601 acaccctgcg gtccgccttc tctccgcata ataaagctgc ggcaatgccg tcaccaaaaa 1833661 gcgaggtgcc gatcagattg ctttttgttt tatcttccgg ctggaatgtc aggctgcaca 1833721 gctcggcaga aatgacaagc acaaaagcct caggatacgc tttgcagtat tcggctgcac 1833781 gcgcaagtcc gctggctcct cctgcacagc caagccccca aatcggaatc cgcttcgtat 1833841 atggagaaaa cggaagttca ttcataagcc gcgcctcgat actcggtgtg gaaagacctg 1833901 tactggagac gaaaaaaaca gcttccactt tctcataagg aatggcttct tgaaaaaatt 1833961 ccggatgaga gaggcactca cgaacagccg ctctgctgtg tttaagtgtt tcttctatgt 1834021 atatttgatt tttttcttca aagctgtgcc cctctttata ccattcaatc ggcttaacaa 1834081 actgtctcga atggatttgc ccgtttttaa aggaggataa cagcctgtca atatccttaa 1834141 aagaatgctg aaacatatag cgggcgaact cggccgcttt ctcttggttt acattatacg 1834201 caggaagact tgttccaatg gataaaataa acgccatgcg atcacctctt tgcatacatt 1834261 gtgccgcaac aatctttttt atatgcaaaa aaaactccgc cgcggcggag ttagactgct 1834321 gttttttgtt cagcgaggtc agcttcttgt tctatttttt tagctttaga aaaaacgtta 1834381 tatacaatat ttaagacgac tgcagtaaag ctgcccgcca caatgccatt cgttgtaagc 1834441 agcgttaagg cactcggaag ctgtttgaaa atatccggca caacggtcac accgagcccc 1834501 aatcccactg agcaagcaac aatcagcaga ttttcctgtt tcgcaaaatc aatgcggctg 1834561 agcattttaa ttccgtaagc aatcaccatt ccaaacatcg ccaccattgc accgcccaaa 1834621 acagcggatg gaataatagt cgtgaaagca gcgatctttg gaaacagccc aaatgccatt 1834681 aggatcacac ctgtgaccac aatgacggca ttttttttga tccctgtgag ctgaacaagc 1834741 ccgacatttt gagagaatgc cgtgtaagga aaagcgttaa aaataccgcc cagaagcaca 1834801 gccagtcctt cagctcgata gcctttagac aaatctatct ctgtcaaacg gcggtttgtc 1834861 aggtcaccta aagcaaagta aacaccagtt gactccacaa ggctgacaat tgcaacgatg 1834921 gacatcgtaa tgataggcgc tgcgtgaaaa gacggcgctc cgaagtaaaa tggctgaatc 1834981 atttgaacaa ctgccgcgtc cgaaacatta tcaaattgaa cttttcccat aaaatatgcg 1835041 atgaaggtgc caatcaaaat accgatcaaa atcgagacgg acttgataaa gccttttgta 1835101 aaacggtata gaagcacaat gatactcaac acggtaaaag caagtgcaag attggagaga 1835161 tctccgaaat ctgcacttcc ttctccgccg gccatgttat tcatggcaac cggcatcagt 1835221 gtaataccga taatcgtaac aacagagcct gtcacgaccg gcggaaaaaa cgatacgagc 1835281 tttccaaaga aaaatgaaat aagaatgaca agaatgcctg aagcgataat gctgccgtaa 1835341 actgttgaaa ccccatattc agatccaatc gctatcatcg gcgatacagc tgtaaaggta 1835401 cagccaagca ctaccggaag cccgatccca aaaaatcggt tgctccacac ttgcagaagt 1835461 gtagccacac cgcacataaa aatatcaatc gatactaagt aagtcagctg ctcgacagtc 1835521 agtcccattg cttttccgac aatcagagga acgacaatgg cgccggcata catggcaaga 1835581 acatgctgaa tccctaaaga cagcgttttg ccgaatccat ttctcatgaa tgaacctcct 1835641 gtacgaagga cacttttcct tcttctaaag actgaattct tgccaaagat tccactcggt 1835701 agcccagttt tacaagttca tctcttcccg gctgaaatga cttttcaata acaatgccga 1835761 ttcccgcaat agaagctccc gcttgcttca caatcgacac aagcccgtgc gctgcctgtc 1835821 catttgccaa aaaatcatcg ataatcagca catgatcctg atccgacagg tgggtcccag 1835881 acactgcgat ttggctttct gtttgcttcg taaaggaata aacagacgct gtcagcaagt 1835941 tgtcggtgag tgttaacgat ttatgctttc tcgcgaagac aactggcaca cccagcttca 1836001 agcccgtcat tacagcggga gcgatacctg atgattcgat tgtcacaatt ttggtaatac 1836061 cgtcttttgc aaacctagac gcaaattcat caccaattct ctgcataagc agcggatcaa 1836121 tttggtgatt caaaaaagaa tccactttca atacctgatc agataatacg acgccttctt 1836181 cctctatttt ccgtttcagt gcttccatcc tgtctacctc cgttatgaga ataaaaaaag 1836241 cattgcccgc tcaaataaag agcaagcaat gctgatatca caaaaaaccg tacacgtgcg 1836301 gttccattgc tcacccatag tcggacattt acggtgcccg gtagaaactt gcgtgccata 1836361 tccacgcgat tatatgagtg ttcctattat attgtaataa attatatcaa gattctaatc 1836421 tcttgcatag gctgaaaata aaaattcccg aactttaatt ttgttttttt agatatcatt 1836481 cgtatttcaa ggggattcga tataaaagag tctgacgacc gcgccgccag gcttttgatt 1836541 ataacagata gagatttgaa tatttgtttg ataaataatc aattaaatag cgaacattca 1836601 gctcttctcc tgttgcatct ttaataatgt ctaacggctt tttccgtttt ccgtgaatgt 1836661 gcaccttttc cgtcagccat tgctttatcg gatggaactc tcctctttcc aagagagcgt 1836721 caaattcagg gagatcctca agcatttttt gtttcagctg agccgcatac atgtagccga 1836781 gcgcatagga tgggaagtag ccgaaatctc cacctgccca atggacgtcc tgtaaaatcc 1836841 cctctgcgtc ggtctgcggt gtaatcccta aataatcctg gtatttttga ttccaaagcg 1836901 acggcagatc ttccacagac acttcattgc tgaaaatcgc tttttcaatt tcataacgga 1836961 tgatgatatg aagaggatac gtcaattcat ccgcttcgac cctgataaat gaaggttttg 1837021 attcattgat tgcccggaca aaatcatcca gggagatgtc cttgaactgt acaggtgatg 1837081 cctcttgaat cttcttatag tacggagtcc aaaaatgctt gttgcggccg ataaaattct 1837141 cgtaaaataa tgattgcgat tcatgaattc ccatcgatgc gccgtctgac aagttcgtgc 1837201 cactgagtgc ttcatcaata ttttgctcgt aaatcgcgtg cccgcactca tgaatggtcc 1837261 caaagatcgc cgtccggaaa tctttttcat catatctcgt cgtgacccga acgtctcccc 1837321 gattcagcgt agttgcaaac ggatgaacgg tttcatcaag tcttccgcca tcaaaatcgt 1837381 agccaagctc ctgtaaaaaa tacagactga gctctttttg cttttctttc gggaacgctt 1837441 ttgtaataaa gcttgtatct ggtttatttc cggaagctgt cacctgttta acaagaggga 1837501 taatcgcttc cttcagctca gcaaacaact gatcaagcac ctttaccgtg acgccgggct 1837561 caaacaaatc aagcaatgca tcataaggat gctcttgata tccccaatac gtaataaaac 1837621 gtttattgaa ttcaatcagc tgttctaaat aaggagaaaa caagctgaaa tcagattttc 1837681 ctttcgcttc ctcccacgct gtttctgcct ttgaacacag aatcacgtat tctttgtatt 1837741 cagcctcagg gattttctta ttctcttcat actctttttt cgccagttcc actgcttttt 1837801 tcgtatcttc cgacaagtca tcaaatcgtt catacaggac atcgataagc tccttcattc 1837861 gatctgatgt ttggatattg aatatatctg ttgaaagctg gccgatactt tcggcacgat 1837921 cctctgagcc atttttcggc gcgcctgttc tggagtccca gtgcattaac gcaactgctt 1837981 cgctgtaatg tgagattctt tttaaaagat caaaaaattc tttttcatat gtatgtatct 1838041 ccatatccat tccctcccta ttctagccgt tccattacag gctaatggaa gggggtatga 1838101 aagtcaaatt gtttgtataa aaggctgccg gtatgttttg tggcagcctt tttattcagt 1838161 tgatcgtcat ttgatttttt ggcggaggtg ttctccgctt tttctgcttg atttttttat 1838221 ctacccacac tgttgccagc ggggttaaga gcgaggtgac aataacgctt gtcgcgataa 1838281 ttgcagttgc cgactcagca actggcgcaa atgaggcatt cgcttccgct aatgcatatg 1838341 gcacggctac agccgcccct gccgtagaag aagcggccac tcccgcgaca ccatctcccc 1838401 gcgcaataaa acgatcaagc aaaaacaaag aactgcccga taaaatgacg acagaaactc 1838461 cgataaaaat gccgagcagc cctgattgga tcagcattcc aaaattcaag gtattgccga 1838521 gcgaaaaggc gaaaaatgga atgatcgccg gcacaacctt gctgaataag tctctgagat 1838581 catgatccag atttccaagt atacatccaa gtaaaaacgg gatgactgtc gctgccagcg 1838641 tttcccatgg gaatgcggca agtcccgtca caccaaacgt caccatggtc ataaaaggac 1838701 cagattctgt actgataaag gcgaaagcgc ccgcatcctc ttttcttccc atgtgattca 1838761 tgagcgccaa atacagtccg ccgttcgttt cattcattac cgcgacaatt gctaaaacag 1838821 aaaggcctgc aaaaaagccg gattgtatgc catcgtcagg tataaattgc gctgcgatca 1838881 cgccgagcag cgccgcaaat ccgatcttcc ccaataataa cgtgattcct tttcttgcga 1838941 tatagcctga agaacgaaaa tcaatcgttg ctcctacgca aaagataaaa acacccagta 1839001 tcggcagcgt tccggtaatc aaagcacccg taaaccctcc aaagaactcc gctgttccag 1839061 gcgcaaacgt gttgagcgcc gctccaagaa atagcggaat aatcatcatt ccgccaggta 1839121 cccgttcaat tgtcgccttg attttcatat tgtggattct cccatcctcc ggttatgaaa 1839181 aaacaattcc acttacactt ggaaaacagc ctgcaaatcc tcttttgaac agctgcccaa 1839241 ctggctgccg actccgacgg cgccagctcc ggctctaagc caatcaggca cttcagacgg 1839301 atgtatcccg cctgtcggaa taaaggtcac ctgcgggaaa ggacccgcta aatttttcat 1839361 aaacggaatg ccaaacacac cgcttgggaa cagctttaat gtcgtaaaac cgaatgtcag 1839421 cgcttccata atttcgctcg gagtcaagac gccggggata taatgtgtct ttacaaaaga 1839481 tagatgttca gcaagatcag ctgaaaaacc cggactgaca ataaactgcg cgccagcctt 1839541 agcagcttcc ccagcttgct gcgcgctgat gaccgtaccc gcgccaatta aaatatcttc 1839601 cctattacgg aaggattcga taatatctga tgccccgggg gtcgtatacg tcacttcaac 1839661 tgcacgaatc cctttatcta ataaactctc aatctgctga caggcctcct gcttatcctt 1839721 tgaacgaatg actgcaatca gctttgcttc tttcagacgg ttttcaacga ctttggactc 1839781 catattaata atcccctttc ttttggtgaa ccgttctttg agcagataaa aaagaagcta 1839841 atttctccct ggtcggcaaa ccgtccatat cccccggtgc ctgcacttgc aaagcgccaa 1839901 tcgcatttcc cctttgcacc gcatccttgt acgacaaacc gtctaggata ccgctgatta 1839961 caccgactgc aaatccgtct ccggcgccga ccgtatcaac cacccggtcg acccggcagc 1840021 cttctagaaa tccttcactt gtccccgttt taaagtaagc gccttctttt ccaagtttaa 1840081 tagcaacaaa gctggcacct tttttcaaat aatagtcggc aatgccttca ggtgtttttt 1840141 ctccggtcaa tagctctccc tctgcgatac ccgggaaaaa ccagtctgca agcccagcca 1840201 gatcattgat tgtgtgtacc attgttgctt gatcaggcca aagcgaaggt cttacattag 1840261 ggtcgaatga aatggtcttc cctgcgtttc tcatgtcgtt catgacatga tacgtgaagt 1840321 ctttcatctc ggctgataaa gcaggcggaa tacctgtcac atgcaaatgg cctgcgcatt 1840381 gaaaataatc tctcggatat tcagctgtag ttaatgtgct tgcagctgag tttttcctat 1840441 agtaggtaac ttgcgggtcg ccttctttca cttttgactt cagcagcagc ccggtgggat 1840501 tttcgtcctg cgagcggatc acgcgggaca catccactcc ctctttttta agctcttgta 1840561 aaataaacgt tccgagctga tcattgccga ccttgctcat ccatcccatt cgaaatccga 1840621 gtctggcaag gccgcaggcg acattgcttt ctgctccggc aagcccttta gaaaaagtgg 1840681 atacttcatg aaggcctcca tactcatttg cataaaacat ggccattgat tccccgaatg 1840741 tcaccgcatc aagcttcatc tcttcccaac ctcctcttag ttgagggcac ctaggattaa 1840801 agtgactttc tcatgatgac ttttgcctct aattcaatgg tttgaggcgc tcctttgtca 1840861 ccttcaatcc tttttaatac acgttccatc gccgtcctgc ccatatcatg tgacggctgg 1840921 gcgatcgttg taatgcctgg accgatcagt ttgtaccact ccgtatcatc gaatcctgca 1840981 atccctatat cttgagggat gcgcaggcca agctcttcca tacagctgat gattttcagc 1841041 ataatcaagc cattcaaagc cagaatcgct tttttttgct ccggcatttc cttgtgaaaa 1841101 gaacgaagct ccgccttaag ctgctccttg tcctttacgt caatttcatg caatctgaca 1841161 agcccgttca cattttgaac cgaagccatt tcctgataca cagctgctct ttctgcacga 1841221 gggctgatag aggaaatcgg ttcggtaaac agcgcgacat cagtataccc tttgctgtac 1841281 accttctgaa gaatctcttt tgtgatccat ctgttgtcag tcgttacggt atccagtttc 1841341 agatccggca gtttccggtc aattaagatt gttggaattt gctgttcagc aaaagcgcgg 1841401 agtacatcct tgttttcccc tgttgcgttt aaaatcaagc cctcaaccga atgggcttct 1841461 agctttaaga gcatttcccg ctctttttca ggactgttat ctgtgttgca caccataatg 1841521 ctgtatccat attgatcaca aacctcttcg actcccctga aagcagcgac cgaaaaagga 1841581 tttgtaatgt cagccacaac aaatccgatt aacttgcttt tttttatttt caaaccttgt 1841641 gccattttac tcggccgata attcaattct gcgattgcct ttttaatgtt tttcactttt 1841701 tcaggagaaa tcgcgtcaat ttttccgtta atatagcggg aaactgtcga tttcgaaact 1841761 cctgcacatt cagctacgtc tttgatggtt gtatggcctg ttgttttctt tttcattcaa 1841821 gtgctcctgt atctcatata tttgaaaccg atttcaaaac cgttacaaca aaagaatacc 1841881 ataattttaa aatttgggaa gagttttttt aataatatgt caattcatta ttttttcgtt 1841941 gactcttttc actatttatc ctaaaatttt ctttgaaacc gttaccaaaa tattttcatt 1842001 caagtgatgc tgaaatccta accaaggggg aaatataatg gaaaatcgtt attctgtaca 1842061 tcctgaacaa gtaaaacgct ttacaacaga ggagcttcgc agtcatttct taatggattc 1842121 tttatttaca gaaaacaaac ttacgatgta ttactcacat gaagaccggg ttgtcatcgg 1842181 cggagcggct ccagggcaaa gtgaactgaa gcttgatgca ggtgattttc taaaaacaga 1842241 cttctttttg gaacggcgtg aaatcgggat tattaatgtc ggccagcctg gtgccgttag 1842301 agtcggcgat gatgaatatg tgcttcaaac aaaggatttt ctctatattg gaatgggcaa 1842361 tcaggatgta tcgttttcaa gcctgaacgg ggaaaaagcg aagttttact tcgtctccgc 1842421 ttgcgcccac aaaagctatc cgacacaaaa agccgcccta tctgaactga caccggaccg 1842481 ccttggtgat gatgcagcgt ctaatgtcag aagtctgtac aaagtcattc atcaggatgg 1842541 cattaaaagc tgtcagctga tgatgggaat aacgatgtta gatcaaaaca acaactggaa 1842601 taccatgcca gcacacgttc atgaccgtcg gatggaggct tatctttatc tggatcttga 1842661 aaaggactca aaggtatttc atttcatggg ccagccggac gaaacacgcc atcttgttgt 1842721 tggaaatgag caggctgtcc tttctcccgc ttggtctatt cattctggcg caggaacatc 1842781 aaactatagc tttgtgtggg cgatggctgg agaaaattac acatttacgg acatggatct 1842841 cattccaatg gatgggctga aataagatgg gttatctaca tgacgccttt tcattaaaag 1842901 gaaaaacagc gctggtgaca ggcccgggaa cagggatcgg tcaaggaata gccaaagccc 1842961 tagccggggc tggcgctgat attatcggca catcacatac aagcagtctg tctgaaacac 1843021 agcagcttgt ggaacaggaa ggccggatat ttacatcttt tacattggac atgagcaagc 1843081 cggaagcgat aaaggattct gcagctgagc tgtttgaaaa caggcagatc gacatccttg 1843141 tcaataatgc cggcattatt catcgggaaa aagcggaaga ttttccagaa gagaactggc 1843201 agcacgtact gaatgtcaat ctaaacagcc tgtttattct gacacagctt gctggcaggc 1843261 acatgctgaa aagaggtcat ggaaagatta ttaatattgc ctctctcctg tcttttcaag 1843321 gcggcatcct cgttccggct tacaccgcga gcaaacacgc tgttgccggt ttgacaaaat 1843381 catttgcaaa tgagtgggca gcgtcaggta ttcaggtcaa cgcaatcgcc ccaggctata 1843441 tttctactgc gaatacaaag cctattcggg atgacgaaaa gcgaaatgag gacattttaa 1843501 agagaattcc tgccggccgc tggggccaag cggatgatat cggggggact gcagtctttt 1843561 tggcatcacg tgcttcagat tatgtaaatg gacatatttt agcagttgat ggcggctggc 1843621 tatcccgctg acaaataaaa aagctgacga acgatcgtca gcttttttcc attacatcat 1843681 gtgcggttca acaggcaaga cctttttgac ctcatcaatg atgcgttcat tttctccgcc 1843741 agcgtaaatg tgaatcgagc cgctgtcttg attcgagcga atcaggcgcc cgatgccctg 1843801 ccgtacacgt aacaacatat atggcagatc aacttcttcg aacggatctt ttttcgctcc 1843861 gttgcgcttc gctgtaaata caggatcgtg tggcgggaac ggtaatgacc aaatggtaac 1843921 attcttcaat gcgtcaccgg gaatgtcgag tccttcccat aagtgaactg aacaaagtac 1843981 tgtttcttct tcctcttgga atttctctac taagctgctg atttcctcat caccttcgaa 1844041 gaaaattgga tacggcagct cccatgccgc cgacagctct ttaaactcgt ttaattcttc 1844101 aaaagaaggg aaaagcacca gcgttcttcc tttgtatcgt ttgattgttt caatcgtttc 1844161 agccgttttt tgttcagcgt ccatatctgt ttttgcgtat agattaatac tcatttgctc 1844221 gtcataatca taaggggaat caacagttaa tgacaaataa tcatgaatcc caagactgtc 1844281 ggcaatataa tcaaacgaac cgccttctga cagcgtagca gaagaaaaga tataaggaat 1844341 tttcttagaa aacacttttt cgccaagtac ttctgctacc gttctcggca tcacgacaaa 1844401 ggttgattct gcttcctttt tctccagcca gctgatcgca tccttttgat atagagataa 1844461 tgaatacgcc atttgttcaa catattcttc cactactgac agttcgtatt gatcaatcgt 1844521 atacatttca gactcaaata caagtgcctc accgatttta tcaagtaaac ggcaaagctc 1844581 gtccgccgcc tttttgacac gatggtcatt ttttatttct aaacggtgtg aaccggctac 1844641 ttcctttgat tcttcagaaa gaacatagaa aaattcgtcg tttgcgagaa gcgcatcttc 1844701 aatcaattct gcaaactctt ctctgatgtc attttgcagc aatcgttcta aaaacaattc 1844761 aagagtagac tgcttcactc tataggttag cgctttttgc gcagcaaact ctaacaagtg 1844821 cccctcatca aatacaactg cactatgatc aggcaagagc ggcagctggc cctctcgttt 1844881 gcgtgattct tccgtccaca catgctccat ataaaaatca tgggaacaaa tgattaagtc 1844941 cgttgacttg cggtagtaat ctctggaaag tgtcagaccg catctgtgtc tcatatcaca 1845001 agtcagacag tcctgaaacg agtcgtagct tacgtcagac cactcttcat tcgatagatt 1845061 tgcgtactgc ttacggtcgc catacggata aaagcgctgc atcgcctggg actcgtggac 1845121 aaatgacggt aacgactcat aaagatccag ccatttatca tcatcagaac gctgcattgt 1845181 tttttcaagc ttcttcaagc ataaatattg ctcatgtgat tttgacagcc ttgtatcaat 1845241 tttcagatca agatgctcag ccagcttaga aatatcgccc tcttttttca ccagctgttc 1845301 aattaatgtt tcatccgcac aagcgatgat ggcaggtttg ccgacatacc ttgcatagct 1845361 gattgcaaaa agaagatata ccagcgtttt ccccgttccc actccagctt cggcgaacat 1845421 gacttttttc tctttaaacg cccgctccag ctgaaaagcc ataaatactt gctcgtcccg 1845481 aagatcaaac cctttttcgg gaaggatatc gtaaaacacg tcaccaatcc aattgttcaa 1845541 ttcttcataa aaattctttg ttttcgttaa agaaaaaggc aaacgtgatg ttgtcaccta 1845601 gttccaaccc ccaactattc gacattcaga ccaccaataa tatcattttc cgctgatgaa 1845661 tacaataaaa aacttggcaa tgccaagttt tttgcagttt acttacgatt gatcacatgc 1845721 gacgataaaa aaggatggtc tgttgaataa atatgttcta ccgctttttc taaatcagtt 1845781 tgcgcatgcg aaatcacaga cggagacgaa tcagtcccga gctccttcag ctcgtttgct 1845841 gttgcgtcaa gcgccctttg aataagatta aaatgttcgc tgttcagcat gagatcacct 1845901 ctgatggaaa taatcatcat tgtatgcgaa cttttcattt tatatacatg ctttaccgca 1845961 tgttatcacc gaaacatgca caaactacac ttgatattcc gtctccggat tatccgtctt 1846021 atcaacaata ttctatcagg gagtgatgtt gacatgagtt atagaaaccg attagatcag 1846081 cattctgaac tgtttcatca caattggacg cggcctaaac gttcaaagtc tcaagtaaac 1846141 ggtcacactg aaatgtccca aaccaacatt atattgagaa gcaacgcgaa agctcaccgt 1846201 tggtaacgat agaatagggc tgaaagatga aagaagacgc atgcagagcg tcttcttttt 1846261 atgcgttttc tgttttcttg cgctgcggtc ttacttttga ccagtattga taataatccg 1846321 ttttaataaa cccgttaaag agttttcgtt tcttcgttgc ttttctgcca tatgcttcct 1846381 caaagttttc atttgatgtc agcatataca cagaccaagt atcaagcggc tcgaacgcct 1846441 gccccatttc tttgtacatc tgctcaacgg cttttttctc gccgagacgc tctccatatg 1846501 gcgggttgcc gacaattacg ccaaattcca gatttgtggt aaagtctttg acctgcatct 1846561 gtttgaactg gattagatct cccaatcctg cttcctctgc attttctttt gcgatttgaa 1846621 ccatgcggtg gtctatgtcg ctagcgaaaa ttgtaagcgg ctgatcataa tttgcctttt 1846681 cttcgacttc aagccgcgct ttgttccaca gatctttacc gatccattcc caatcctctg 1846741 atacaaaatc gcggttgaat cccggggcga tgttttggcc gattagcgcc gcttctatcg 1846801 cgattgttcc ggagccgcag aaaggatcaa caaacgggcg gtcaggcgtc caattggtta 1846861 attgcaccaa agcggcagca agtgtttctt taatcggcgc accgccctga tcgacacggt 1846921 atcctcgttt gtgaaggccc gtccctgatg agtccagtgt aatcaaagcc tgatctttca 1846981 ataaagatat ttccacttta tactcagcac ctgtttcttc aatccaatca ttggctttgc 1847041 cggactgcag cttgagcttt tcgacaattg cttttttgac gatccgctga cagtcaggaa 1847101 cgcttgcaag tgttgatttt accgattttc cgatgacagg gaatttcccg ttttcaggta 1847161 taaatgagcg ccagttaatc gctttcgttt tttcaaacag ttcatcaaat gttttcgctt 1847221 taaaagaagc aacctgaacc tttatgcggt cggctgttct aagccaaagg ttcgcacggc 1847281 agatggcaag tgcatcacct tcaaaaataa ctttcccgtt atcaaccttg cattcgtatc 1847341 ctaaatctcg tacttccttt gcgacaacag cttcaatgcc catcggcgcc gttgcaatta 1847401 gtgtatactt cttcatcgta tcaccctgtc ttttaaaact tttctctttt caagataaaa 1847461 gctctcctta tacgggagag cttgttttca tcattttaaa tgtaagtggt ctaacgttct 1847521 gtaagccatg ttttgttcca tcgtactgca aacggctcat cacctcgtac tcaggcggca 1847581 atcatctatc tacagaaagc attctgtcct tctctccgtt gaattccgtt aagaaggttc 1847641 ccctaccaaa atttgggttt ctcgctcgag gggtttaccg cgttccactc tcaccatttc 1847701 tagtgagact tcgtcactgt ggcactttca aggatactca gccatatccg aagacgtagg 1847761 cttttttcct gccgtcagcc tctaaagact gccctagctt atgacttcgc taggcacgaa 1847821 cactacgggc atctcagcac cgtgcgagca tggactttcc tctacagatt caagatctgc 1847881 agcgattacc cgaacgttaa gaacatgaat tattatataa caactgatta caatttacaa 1847941 gcgccatttt tttcaagcgt gatcaatcat aaagcttgct gccaaaaacg tgtttttcta 1848001 agttagacag ccgttttaaa atatcaaagt ttgttgtgtt agattgcaca ggctgttttt 1848061 tgctggcttc ttcaagctgt tttttcagct gcagattttc ctgctgcagt tcttcaattt 1848121 cttgatggaa ggtttcataa tccttaataa tcatatctaa aaatttgtca acgtcttctt 1848181 gcttgtagcc tctaacgcct gttttaaatt ctttttccaa aatttctttc gcagaaagct 1848241 ttactttatc agcaagcatc tttttcacct cgtatcgtga atcatcacat atattttttc 1848301 agaaatctgt acggttgtca aatttctctc tcattgttag tagctgtctt cctccactgt 1848361 cactctcaag tcatccattg taataaagta gatgggatag ccatcctgtt cgcgcctttt 1848421 ttccgctgtc ccaagcatat acttagggga gccttccttt tccgggtcat ataaaagcag 1848481 aagcccgtcg gacttatcaa tgaagaactg atttttttgt ttgaattgaa gcgggctttc 1848541 ataaggacgg tgagtcaggc ttgcttcata gtctgcctga gccagaactg cttcatactg 1848601 ttctttattc ggttctttcc agttcttttc ctgctcgtaa aatggtgtga tgacagctac 1848661 ctttaagtca gggtattcct cctgcaaatc atatgcagct tctgccgccc acagctcaac 1848721 tccaagctgg cccgaaatta aaatccattc taatccttca tccaaaaaag caatcagccg 1848781 gtttttaatg gcttttttta tgtaatacag cgccttgtca tcctgcttaa atatccccag 1848841 ttcaaacggt ttatagcccg ttattgccaa tactttcatc atttcacctg ctttaaaaaa 1848901 tggggctccc gtgggcccca tttgttgtgc tgcattgttt acaccatcaa gctgcacgtt 1848961 ttccatacta gtagtcgcag caaggttttc ctgcttgaaa atgctgatgc gtagccgggt 1849021 caacatttga gaaagtgtgt ggaaagtagt gaacgtgctg aaaatgctgg tggtttacgt 1849081 ttgttgtatg ctgtgggtga atgtgcggca cgatagtctt cgaaaacgta tggtgttcac 1849141 agcaatgagt aggatggaca attggcgcca tcatatgcgg tctgcagtga tgcatgataa 1849201 aatccccttt ccataaactt tattacaata ctaagttatg aaaaataagg ggtacatgtt 1849261 ctgatgcaaa gacctatttt aaaagtgtgc aattaagctg tctttaaagt ttgaaaacac 1849321 aaaagcaatc aaaaatacca caacaaagaa caagtaaaaa acacccttat acataccaac 1849381 tctcccttta aaaataacta acgtcatttt acaggattcg ccgctattct acaacaaaat 1849441 caatgtgaat tcagcaaaaa aaattcatgg cgaaacaagt cgtcttttgc gctttcccgg 1849501 ggaatattta agaggaatat ttcctcttta gccgggcaat tctcacatgc agtttttcag 1849561 tttctttctc tgataagcat gccgcatcgc taagcgattg ctctgctact tgcaatgctt 1849621 ttccgaattc ttttttctta tgctcaaaat atttcgcgag ctctattaca gcagcgtatc 1849681 tgcacttctg gttttgcgag cgggacagct tttcccaaag cggcactgct tcttccaagc 1849741 ggttttgttt tttgtacagg agcgataaat ccagccgtgc actgtcctgg tcctcaaacg 1849801 atttttctat aagcctttcc aactgcttga tcgcttggtc cgtttcttta tgagccataa 1849861 accatttcgc catagcatag gcttcactgt gttcttttgg cgcatgtgat tctgaaagga 1849921 tttttttaga catatggatg tacaatgaaa tgagtgataa cacatccatt tcattatgat 1849981 gcaggacacc ttttaaaaga tccggctctt gcgccttgat aaaatgaaag taaagcattg 1850041 gcgccaagta gcccggtgtg tcttctagcc tgcggatgcc gagctcctct ttttcaaccg 1850101 tgccaagaga tacacggtcc attttgtgtt tccacaggcg tctagctcca tgcaaaagat 1850161 caaagtggcc aaactccgga agcttcggaa gtctgtcacg gatcaaggtg tgccttgttt 1850221 tcacctgcgg ccaatcaaag gctttgccgt tgtaggtcac aagtgatgta atgtcaacct 1850281 cgcttaaaaa gctttggtac aaggcgactt cgttccccgg tttgggcaaa agatgctgtt 1850341 tgactgtcac tcggtcttca tatactctcg catgcccaag caaaaaaatg gtattcccag 1850401 ctccaccccc aagaccggtt gtttctgtat caaagaaaaa gaggttgttt ttgttatacc 1850461 cttttgctga caatgtatgc gacaggccgc tttgattcca cagtgtgatc acttcctcaa 1850521 gctcagaaaa gctgtataac ccatggcggt gagaaagcgg atattctact tctctgatga 1850581 ggcaatattc atcttcgaag atgaaaggct tcatgccaaa agcctcccac tcttctaaaa 1850641 acgggatgtc atcaaagtgg ttttcttgtt tgcctgcttc tattttttgt tctccttcgt 1850701 cgagcgccat gtgctttttc atccgttgga gtttcccttt taatgacata tccggcctcc 1850761 ctccttacga catttgatcc aacagctgca aaattctttc ctttgctttt atcccttcta 1850821 tttccgtacc tatacaagac ggacagccgt catgacaagg acaatgtgta atcagttgtt 1850881 tcgccgcttc attaatgtct gaaaaacgtt taaagacttc ctccgccaaa ccgataccgc 1850941 ccggataatg atcatataaa aatatggttg gcaatccggt atgggctgct ttaatttgag 1851001 aaacaacatg aacatcattt cgatcacaca tgatatacac agggacaata tgctgcagca 1851061 cattcgagat gccaagaagc agctgttcca gtgtcttttc cccgatgtct tcatccgctg 1851121 ttttgatttc gagccaagct gcacttgtat gcagttcttc ttccggcaaa tgaataggtc 1851181 cagacccaat attttcaaaa gtggtcattt ttattttttt aaaaatggtc ggcagggcat 1851241 tgacagtgac gtctccgtag tgcaatgacg tacggctttt ttctttcgtt ttatcgattt 1851301 ctaatacctt cagctgaact gccaggtttg catccgtata atattcgaca tcgacttttc 1851361 tgacatacgc ctttttatgg tcccaatcga gcttctcaac ttgatactga acgccttcat 1851421 gcaaataaat cgcttcatca tgcaaaagcg tcatcgcact aaaacggtcc atttcaccga 1851481 taatccttac atttgcaata tccgactgat caactataac gacattttcc tgggaggcgg 1851541 aacgcaaact gatgtttgac gcagggaacg actcacttgc ccaatggtac cgttcgccgt 1851601 tgcggtgaag aacagcctct tcctgaagat actcaagaat atcactgact tccatggctc 1851661 caaattcttc atcagctcta aaaggaagct cataagccgc acactttaag tggtctacta 1851721 aaataatcaa attctccgga ttgattcttg cagattccgg cgaacgatta aagaaatatt 1851781 caggatgccg cacaatatat tggtcaatcg gtgttgaatt ggctaccatg ataatcaaag 1851841 attcaccgtg tcttctgccg gctcgtcccg cctgctgcca agcacttgca acacttccgg 1851901 gataccccgt cattacacac acttgcagct ggccgatatc aacaccaagc tctaaggcat 1851961 tcgtactgac cactcctaaa atgtcgcctt ctctcagtcc tctttcgatt tctcttcgct 1852021 ctttcggcag atagcctccc cgatagcctc tgattgattt tgttccaatc tcttttttca 1852081 caagctcctg aatatggctt aaaataattt ccacccgaac tctgcttctg gcaaaaacaa 1852141 tggtctgcac tttgttttta aggaactctt tcgccagttc attcacttct gcggttgcgc 1852201 tccttctaat attcagcggt ttgttcacaa ttggcggatt gtaaaacaca aaatgcttgc 1852261 gtccgctcgg tgcgccgttg tcatcgacca gccgcatcgg tttgcctgtc agctgctctc 1852321 ccaattcctt tgggttggca atcgttgcgg aagtacaaat aaaaactgga tcacttccat 1852381 aaaaccggca gatccgcttc agccgccgga tcacatttgc cacatggctg ccgaacacac 1852441 ctcgatacgt atgaagctca tcgatgacga tatacttaag gttttcaaac aaactgaccc 1852501 atttcgtatg atgcggtaga atggcagaat gcagcatatc ggggtttgta atgacaatat 1852561 gacctgcttt tctcaccttt tgtctgattg ccggagacgt atccccgtca tatgtaaagc 1852621 ttttaatatc aatgcccatt tcatcaataa tttcatttag ctcgctcttt tggtcttgtg 1852681 ccagcgcttt agtcggaaat aaatataacg cccggtttgt ttcatcttgg gcgatggact 1852741 gcaggactgg gaggttgtag cataacgttt ttcctgatgc tgttggcgtt acggtaacga 1852801 tgctctctcc tttttgcaca tattgaaaag cggaatattg gtgagtatat agttcatcaa 1852861 tgcccctttt cgaaagggcc gctttgattc tctcgtctat actttcgggc ataggccttg 1852921 tttttgcttc ccgaggctca atttcatgcc aattcacaac gttttcattt ccttttaaat 1852981 cagaaatgag ttcagtcagt gatttctttt tcattcttta cacctctttg tcaagtacag 1853041 tttaccgaat atttgtttgc atggctaggt gcaaatttta tacagttgaa taaaaaaagc 1853101 aaggcatacg ccctgcttat ttcgctttta ttgtaaagag ctttgattcg cctttacgag 1853161 cagccttttc gcctgccgat accattgatc ctacagcctc accattcatt ataacgattg 1853221 ggatgactgt gctgctcgct ttttctttta ttaattccaa atcacatgta atcagcgggt 1853281 caccgacctt cactttatcc ccttctttaa tgtgggcagt aaatccttct ccgttcatat 1853341 tgactgtctc cagcccgaca tgaattaaca gctcaattcc cgagcgagtc cgaatgccaa 1853401 cggcgtgttt ggtgtggaaa atctgaatga cttcaccttc agcgggagaa acgatttcac 1853461 cgctagaagg ttccaccgct attccttctc ccatcatttt ctgtgaaaaa acagggtccg 1853521 gtacatctga caggtccatt actgtaccgt ctgccggaga ataaataacc tcttctgtca 1853581 ccttttcctg aattttgccc attccgaata attttttcag caatgtattt tctcccttct 1853641 cattcacttc aaccgttatc ccttcattca ccactattta accacacttt caattttgct 1853701 tcaatttata acaacatctg gcatagacgc ataatctggt taaaaaaggc ggtggcgata 1853761 ttggaattcc atgatgacaa aaagaacgaa ctgcaaaaga aagaagaaat cataacggag 1853821 gcaatcgaca ctctttttca atcctcagcg ttcggcaacc ttataaacgg atttcagaac 1853881 ctaatcaact cgagtttaaa ggatgtgcag acgaccatac atgtcagaga aagagatact 1853941 gggctgtata tcgatattac cattccggcg acgtttcgag atggcgagat cgtcgttgat 1854001 gttaaatcga ggtatctcca tgtaacactc caagaaaaac agaaacacca aaatgaggct 1854061 acctttacaa gcatgacaag aacggttcag ctgccttatg aagttcgcca agaagatatg 1854121 gaaacgtctt ggaacgagca gacaatgaca cttttctttc caaaaaataa gcatgaatga 1854181 acgattcatt catgcttcta tcatttaaaa aagctggtaa atccctttat taaagatccg 1854241 acctgattca ttgcactcat tacttgacct gtcgtatcca tcattttatt aaaatcaaat 1854301 tgcccattgg cttttttgaa ctgcgacata atgctttgaa attgtgaagg ctgctgttga 1854361 ttaggccttg ggataggata agggttagaa aatacaggcg gctgcatagg cataggctgg 1854421 atcggagcat aaggctgata ataatcctgc tgtccataat gctgctgagg cagttgttgc 1854481 tctaaataac cgggtgcagc ctgctgataa tatccttgca tatgctgagg ataataatag 1854541 cccatttgcc gaggatagct tcgagagctc ccgttcattg cgattccccc ctaaacacaa 1854601 catatttctc ttctatatat gtatgaatga cttctattgt ttgtgtcaca agtgatgatt 1854661 agcatttgtc aaattgtgtc gaaagtttaa attttttaaa aacagaaaaa agtcgaatca 1854721 ttatggtacc atattttcaa tacagatgag aggggatgca ccataatgaa cgtatcatac 1854781 ttaagcaaac gttttgcaga aatgaagaaa tatgaaacag actgtatgaa taaactgatg 1854841 gactttgcca agttcctcta tattcaagga catctcagca taactgagtt tcgtaacagt 1854901 atgaaggttc tcgaagcaaa tggagcagaa agcccggcat atgagatgaa ttaacgtccg 1854961 gccccctata aaaacgaaaa gaagacagcc ttttaccggc tgtcttctct tgcaatttca 1855021 tcctttactg cgtgcaatgt ataaaggact gactcagtga tgtccttgaa tcgtttttta 1855081 tgaatatgat gaacataaga ttgaaggacc aattccagga aattatcctt tacggcctca 1855141 atttgctctt tatgcacata ttttggccgg cggactttta tcaattcaag agcaccctct 1855201 gcccagcgag cagccagttc atcattctct tcaactgcag gctttatcgt ctcaaaaaaa 1855261 tcataagaat gattactgtt ttttccttcc tgataccgat cagcgccttt ttcagcaact 1855321 tcaatcattt gctcggtcat ttccagcaaa gtttgtgata gcaatatctt tcacctcaat 1855381 gcctatcgta ccaaatttca ctcacaaatt cagccgatgc ggtatacctt ctcaaacgca 1855441 tacctgtgtt caggcgattg atacagctca tttatacaaa tatgaagatc tatgatttct 1855501 tcttcgagca cacttaggcg atcgttctcc gtttcccgca tctcagcctc taatgcattt 1855561 acagaatgat tcaggctttg ctcagctcgc gttaattcat cttctatatc agaaagcata 1855621 cggagaatat ctgtcttgca tacataaccg gacattcgtg tacctccctt tccttgtctc 1855681 tcccggttaa cattctttgc tctcaaggct ctttccttcc tcatgacaaa actagaagca 1855741 aatcgccaaa caaacaggta ttccacgaaa agctgaagtt ttcgacaaaa acacccgcaa 1855801 aaattgtatg atcctcctca ttaatgcaaa cgatacttgt gaggaggtgc cgtatgaaaa 1855861 caagaccgaa aaaagccggc cagcaaaaaa agactgaatc aaaggcaatc gattctttag 1855921 ataaaaaatt aggcggcccg aaccgccctt ctacgtaaga agcaaggaat ttccttgctt 1855981 ctttattttt tcagccactg ctccaccgca aaaagcgcat gaagctggcg ctttttatgt 1856041 aaataccagt ctgtcaattc aatctgcttc ggcaattcct cgcgcctaaa gaacgttttc 1856101 tttatctttc catgaaacca atctgttttc gttccgtcta atgagtggat taactcaggg 1856161 tagcatgtcc ttagcatagg agatgttctt tttgtaatcc cgatcatctt ttccatatca 1856221 aaacgggaac ctgtgtgcgg cactgtgtgc aaaaagtgat aaaaagagga gaacaattct 1856281 ggcttgaaca gcaattgaga cagctgcttt cccagcctta tcctttcctc cgcctttgaa 1856341 aagcgtttca ctgaaatgcc gtaaaaaaac ccatttgagg aaggaaaaat aacggtgtta 1856401 aaatgaaacc agtcacttaa ataaaaagga atcgtgtcaa aaacattctt tttaaacgaa 1856461 ggattttgta taataggtgt ttggatagtg ttttgttcat ttataatgag ggcatacatt 1856521 agccgctccg tatttcgctc atgccaaaaa cgggtccatt cttccgacat aaattgtgag 1856581 acgccaaaca catgcagcag atgaaacagc ggtttcccaa ctctttttga ccagtggtat 1856641 aaaagaagct gcggataggc atccgaaaaa ataagccagt tcgctctttc ataggctaaa 1856701 aagaaccatt tttgctgtct ctcacggagt ccaagctgaa acagactgcc ttttaagtca 1856761 gtcattgacc agccggcatt acgagaaacg aaagaagcca aaagcgacca tttgatttcc 1856821 ggatgacggt cgtaaaatgc tttataagca tttgttcttg aaatgttatc cgcgtttttc 1856881 atttttgtct gccgctcaat ccggctcaga agctttctga tggcctgttg ttcttgcacg 1856941 ttcattcact tccgtcatga ttagtttaat aaggaggatg agaaagtgat tcggtatcct 1857001 aatggaaaaa catttcagcc gaaacattcg gtttcatccc aaaacagtca gaaaagggcc 1857061 ccgtcttaca gtaatcgcgg aatgaccctc gaagatgact taaacgaaac gaataagtat 1857121 tatctgacaa accaaattgc cgttatacac aaaaagccga cacctgttca aattgtaaat 1857181 gtccattatc caaaaagaag tgccgcagtg attaaagaag cttactttaa acaatcatcg 1857241 acaacagact acaatgggat ttacaaaggg cggtatattg attttgaggc gaaagaaacg 1857301 aaaaacaaga cctctttccc cctgcagaat tttcatgacc atcaaatcga gcatatgaag 1857361 caggtaaagg ctcaagacgg tatttgtttt gttattatat ccgctttcga ccaggtttat 1857421 tttttggaag ccgataagct gttttatttc tgggacagaa aagaaaaaaa cggcagaaaa 1857481 tcaattcgaa aagatgagtt ggaagaaaca gcttatccga tttctcttgg atacgcaccc 1857541 agaattgatt atattagtat tattgaacag ctttattttt cgccatcatc tggtgcgaaa 1857601 ggttgattaa cgaaaggttg agatgttatg tcagatcaat ttaacagccg tgaagctcga 1857661 cgaaaagcga acagcaaatc gagtccttca ccgaaaaaag gcaagaaacg aaaaaagggc 1857721 ggattgttta aaaagaccct tttcacttta ctcattctgt ttgttttagg cgtagtcggc 1857781 ggtgctgtta catttgccgt catggtttct gatgcgccgt cccttgatga aagcaaattg 1857841 aagacgcctt attcatcaac gatttatgat aaaaatggaa aagagatcgc cgaagtcggc 1857901 gccgaaaaac ggacctacgt ctcgatagat gaaattcccg atgttgtaaa agaagccttt 1857961 atcgcgacag aagacgctcg tttttatgag caccacggga ttgaccctgt ccgtatcggc 1858021 ggtgcattag ttgccaactt taaagacggc ttcggggctg aaggcggaag tacgatcacc 1858081 cagcaggtcg tcaaaaactc ccttctttca catcagaaga cgttgaaacg gaaggtgcag 1858141 gaagtatggc tttcgattca gctggagcgc aattactcta aagatgaaat tttagaaatg 1858201 tatttaaacc ggatttattt ttctcctaga gcatacggaa tcggaaaagc ggcggaagaa 1858261 tttttcggcg ttactgattt aagcaaattg actgtcgaac aggctgcgac gcttgcagga 1858321 atgccgcaga gcccaacagc gtacaacccg gtcaaaaacc cggataaagc ggaaaaacga 1858381 cggaacatcg tactcagtct gatgaaaaag caaggattta tttctgattc tcaatataac 1858441 aaagcgaaaa aagtggcagt gaaagacgaa ggcgtcgtgt cacagaagga atatgaaaaa 1858501 gcaagtacaa acaaatacag cgcatttgtt gaagaggtta tgaaggaaat tgatgaaaaa 1858561 tctgatgtcg atccatctgc tgacggatta aagatctata cgacattaga tacaaaagca 1858621 caagataaac tagatgaatt aatggacgga gacaccgtcg gatttactga aggcatgcag 1858681 ggcggtgtga cgcttctcga taccaaaaac ggagaagtcc gagcgattgg tgcgggacgc 1858741 aatcagcctg tcggaggctt taactatgct actcaaacta aggcacagcc tggttcgacc 1858801 ataaaaccga ttttggacta cggaccagtt attgaaaata agaaatggtc cacatacgaa 1858861 caaattgatg actcagctta tacgtattct aacggaaaac cgattcgtga ttgggaccgc 1858921 aaatatctag ggcctatctc aatgcgttac gctctggccc aatcaagaaa tatacctgct 1858981 ttaaaagcat tccaggcagt cggtaaagat actgctgtag actttgcaaa tggactcggg 1859041 cttggtttaa caaaagataa tgtaacagag gcctattcta ttggcggttt cggtgggaac 1859101 gatggtgttt ctcctctgac aatggcaggt gcatacagcg cgtttggaaa taacggaacg 1859161 tataatgaac cgcattttgt aaaatctatc gaatttaacg atggcacgaa gcttgactta 1859221 acaccaaaat caaaatcagc catgagtgat tatactgcgt ttatgattac agatatgctg 1859281 aaaacagctg tgaagacagg tactggacag cttgcacaag tacctggtgt agaagttgca 1859341 ggaaaaacag gaacgactaa ctttgatgat aatgaagtca aaaggtacaa tatcgctagc 1859401 ggtggcgccc gagattcttg gttcgttggc tacacaccgc aatatacagc tgccgtctgg 1859461 acgggaatgg gagaaaacga ggctggaaag aaatcacttt cagctgaaga gcaaaaagtt 1859521 gcaaagcgca tcttcgccca gctcatcgcc gatgtcgatg acggaagcgg atcatttgag 1859581 aagcctgaca gcgtagtgga agccaccgta gaaaaaggtt ctaatccggc aaaactggca 1859641 gggccaaata cgccaagcga taagaagctc acagagtact ttgttaaagg cacagctcct 1859701 tctactgttt ctaaaacata tgagaaagaa gaaaaagagg aaacagctaa actgtctggt 1859761 ttaaacgtga aatacgataa agacaatcaa tctttaacgt taagctggaa ttacgacgga 1859821 gatgcgacct ttgctgttaa gcaatctgtt gacggcggca gctactcgga aattcaaaac 1859881 agctctgcaa aagaggcagt tatttcgggt gtgcagccag gatctgtata caaattcgaa 1859941 gtaacagccg tcagtgatga tggcaaaagt acagcttcca catcttatga ggtgccaaaa 1860001 gctgaagacg atgaagataa aaaagaccag caacaaacgg atgatgaaaa acaagatgat 1860061 gagaagactc aggatgatac acaaactgat gattctcaaa aagatgacgg tcagacggat 1860121 caagatcaga cagatgattc aacaaacgat caagacaaaa aacaagacaa tacgaacacc 1860181 aatccgtccg acaacaataa ccaagaccaa tcaaacgata atgataacga caacagtaac 1860241 aaccaggata cgtcggatgg tgattcgaac tctggtaaga atgattcaac aggttctgac 1860301 acgaataaaa ataaaacaga cacatctaat aaaacacaaa caaactcatc atccattgaa 1860361 aaaacaaatt aaacaaaaaa gccgtcacct ttggggtgat ggcttttttg gtacacaata 1860421 aaaaacctcc cgttttaaca ggaggtttta tcgattcatc gcatgatatt tataaaaatg 1860481 ctttttcatt tcggtaatca gctcatcaag ctgaataaag caatggtatt gggtcggctt 1860541 aagaagaata aattccactc gttcagccca attaatcggc tttgcgggat atgatttctc 1860601 cctcagttct tgccaatcga gcgatttcac cggctcacct gctgtccaat gtaacgaagc 1860661 cagcaaacac acaatgccct ttaacatttc gttttggtca catctcgatt ttcgtgtttg 1860721 aaagactggg agaagtgatg ctttgatgtc atcccacact tcaaataaaa gcggaacgta 1860781 tttcccgctg tcctcccatg gcaaatcgcc ttgtaattcc gtgcagaaat caaaatacac 1860841 gggattggtc tgcaaggttt tcttcatatc cgaggaactc ttctggccaa gactgcgcaa 1860901 gtattgctca taggaagcca acacttcttt tgcttgcgtc atcgtttcac cagtcctttt 1860961 ttatccctct tctgcccttc tctgcacaaa gaaagcagcg gacactccgc acagcgcgga 1861021 gattgggctt tacagtgata tctgccgaag aaaataagcc ggtgatgcgt aacggaccaa 1861081 tcttctttgg gaaccttgcg catcagcgtc ttttcaactt ccagaaccga gtccttccac 1861141 cggcaaatgc ccaatcgttt gctgactctc tccacatggg tatctacggc tatggccggc 1861201 acgccaaacg caacggatac cactacgttt gcggtctttc tcccgacccc tggcagtttg 1861261 acaagctcat cgcggtctct cggcacttct ccgccgtaat cttcaataat cattttactc 1861321 agcttttgaa tatttttcgc tttattacga tataaaccga ttgatttaat atcctgctga 1861381 agctcttcca gcggaacagc caaatagtct tccggccgtt tatatttttg gaataatgtt 1861441 ttggtcactc tgtttacaag tgcatctgta cattgcgcag ataaagcaac agccaccact 1861501 aattcaaaag gattggaatg aaccagttca cactccgcat gaggaaacat gtcacctatc 1861561 ttgtctaaac agaattcaat ttgttttaga tttaacacga ttgtcacctt ttcactttat 1861621 tgttcaagcc aattgtaaaa aggaacctgc cttttatact ctttttgcgg ttcattctgc 1861681 tttgcttgta cacgccggaa tttttggctg tgtatttttg cctgctccac agttttaagc 1861741 ccatttttct tccattcaaa caaaatccgg tcaatgtagc ggaaactgag ttttcctgat 1861801 agtacagcct cttttaacgc gtgtttgatc agttgtgcgt catgctgatc ctggtcctgc 1861861 cagatcgcca gcgtttcaca ctccaaaggc gataacggtc ttgcgaactc ttcctcaaaa 1861921 atggtataaa ggcttttttg ttccccttct gcttttcttt cctgtgtttg attctgtgca 1861981 agctgaatat actcgtacag cttgccccat aaaggctgaa gagaatattt ctcaaatttg 1862041 atgccgtttt gatcctcgca ttcttcaata aacagaaagc ctttttgaat aaacatccgc 1862101 aatctgtttg tacattcttc aacagaaatt gacatacctt cctgcagctg attcggtgta 1862161 ggaaaatatg atcctttttc taaatgcatt ttaattttta acagcagaat aagttctgtt 1862221 tcattaagcc caagctgttt ataatgcgtg agcagaagat tggggatggt tgatgttccc 1862281 tgctcctgca tatcaataaa ttgctgtttt ttcatcgtca cacctcttac tgtaaaggat 1862341 tgtgattgcc cctttactgt aaaaagtctc ccttgcagga gactcttttt tgtttcattt 1862401 gaatgtatta cggatacaga cggtttaaca gtcttgggaa cggaatcgtt tcacgaacgt 1862461 gaggcgctcc gctgatccaa gctactgtcc gctctaatcc aaggccgaag ccggaatgag 1862521 gaactgatcc atattttcta agttcagcat accatttata agcgtcagaa tccagtccat 1862581 gttctttaag acgcgattcc aaaagttcca tatcgtgaat ccgttcagac ccgccgatga 1862641 tttctccata gccttccggc gcaatcaagt cagcgcaaag cacaacgtcc tcacggtcag 1862701 aagccggctg catatagaac ggttttaagg acgtcggata gcgagtgatg aataccggtt 1862761 tgtcataatg ttcagcaatc gctgtttcat gaggcgctcc gaaatcatct ccccactcga 1862821 tatcgtcaaa gcctttttct ttcagaaatt caatcgcttc atcatacgta attcttggga 1862881 acggggcttt gatttgctca agttttgacg tgtctcttcc caatgtgttt agttcaattt 1862941 tgcaattttt aagaactgat tgcacgatga aagaaacgta attttcctgt acttgaaggt 1863001 tttcttcaaa ttctacaaac gccatttccg gttcgatcat ccagaattcg attaagtgac 1863061 gctttgtttt agacttttcc gctctgaatg tcggtccgaa agagaatact tttcctaaag 1863121 ccattgccgc agcttccatg tagagctgtc cgctttgaga cagatatgca tcttcatcaa 1863181 agtactttgt cgcaaagagt tctgttgttc cttcaggtgc gcttccagtc aaaatcggcg 1863241 gatccacttt tacgaagcct tcgttattaa agaattcgta agtcgcgcga atgatttcat 1863301 tacggatttt catgatcgca tgctggcgct ttgaacgcag ccataaatgt ctgtgatcca 1863361 tcaaaaattc cgttccgtgt tcttttggtg taattggata atcggtcgct tcgtgaatga 1863421 cttcaatatc tgtcacagca agttcatatc caagcggaga acgctcgtcc tctttgacaa 1863481 tcccttttat atagagcgac gtttcctgcg tcactgattt agctgtttgg aaaatgcttt 1863541 cttccacttc cgcttttact acgacaccct gaataaaacc ggtaccgtcc cgaagctgta 1863601 aaaacgcaat tttcccgctt gaacgcttat tagcgaccca agctccgatc gttacttcct 1863661 cacctacgtg cttgtacact tggttgattg ttgttttcaa catatttccc tccaaaacaa 1863721 gaaagacatt cggaagctca ttgccccgcg aactctttta tcatcacttt attatacccg 1863781 ctcttaacta accgggtcaa tgcagataaa aagcggcttt tctgtcagcc gctttttgat 1863841 ctgttagcta tgtttttcta caaaacgctt gattctttca atggcttctt caagaagatc 1863901 taacgatgtt gcataagaaa gacggacatt ctcaggagag ccaaatccgg atcctggaac 1863961 aatcgcaact ttttcctcct cgagaagcgc tttaacaaat tcatctacat ctttgaaacc 1864021 gcaagattga gctgcctctt ttgcatttgg gaacaagtaa aaagcacctt ccggcttcac 1864081 gcagctgaac cctgggattt ctatgagctt tgcatagatc gtatttaatc tatgttcaaa 1864141 tgcttctctc atttcttcca atggctcaga aggcccgtta taagcagcaa tcgctccgta 1864201 ttgtgcgatt gatgtcgggt ttgacgtgct gtggcttgca aggttcgtca tcgctttaat 1864261 aatgtcttca gagcctgccg cataaccgat tctccagcct gtcatgctgt gggacttcga 1864321 tacgccgttt ataatgaccg tttgctcttt cagtctgtct gacagctgtg caatggaaac 1864381 atgtttcttt ccgccgtatg taagtttttc ataaatttca tctgacacaa tcaagatatc 1864441 atgttcaagg cacacttcac cgagcgcaga tagttcttct tccgtataca tgacaccagt 1864501 cgggttgctt ggagagttaa taacgattgc ttttgttttt tccgtaattg catttttcag 1864561 ctgctcaggc gaaattttga agtgattttc ctcaagccct tctacataaa caggctttcc 1864621 gccagcgagt ttcacctgct ccgggtagct tacccagtaa ggcgttggaa taataacttc 1864681 atcttcttca tccaaaatca cttggaaaag ggtatacaga gcatgtttgg caccagtgca 1864741 gacaataatt tgagacggtt tgtattcaat attctggtcg cgtttaaatt tctctgcaat 1864801 gctgtttttc agttcagcca aaccaccgga aggcgtgtat ttcgtatggc cctcgttcat 1864861 cgaacgcaca gcggcatcaa taatatgctg cggtgtattg aagtcaggct cgcctgctcc 1864921 taagccgatg acatcatggc ctgcggcttt cagttctttc gctttcgctg tgattgccag 1864981 tgtggttgat ggtgttaatg cggatactct ttttgccagt ttcaacttga actcccccta 1865041 attcgtctta aggcgtgata tttttgagaa tctttccagt tgtaaagtcc acataactta 1865101 aactgtattg cccttctttg tctaagtacg tcacttccca aagcaggacg tttccttctc 1865161 ttgccagatg aacctctttt tgctttgaaa ccagcccttc atcctttatg attttcgccg 1865221 ctttgtcttc agagattccc tctttcgctt cttttgagag aatttttgct tttttatcag 1865281 caggaaccca gacatataat gcagtgcctt ttttatccgt tccctttaca acataatatt 1865341 tttcttttcc gacaaatgtt tcgacttgat caacatgggc gagatcggtt tcttttttag 1865401 cttcagcagc tgctgcttcg tgcccctctt ccttttgtgc catggctgat ttataaatgc 1865461 ttgccgagac aagaagtact gctaaaaaaa taataccaaa aatgacggta aatattaatg 1865521 ctttttttct catcttctca cctacgtacg ataaatggta aaaacggctt ggtttttgtt 1865581 ttcttcatcc agcgcaaggc cgaacatcag attgtctctt ttcagtgtac gattcaatgt 1865641 gtccacaatt ttatacagat catcagaatg ctctacatta attgttgaaa gaatttcgat 1865701 tttactttcc attttttcat cctccagttt gaacaaatat tgttagtcat actccatttc 1865761 aggacacgcc atactagtat cacagagcgg gaaatccgct tttaaataaa acaccatcct 1865821 actcccacac cgcaaaagcc gctttatgcg gcttttattc tttttcccct gcaacataag 1865881 cttcaagctc gctgtcagtc atttcggata ctgaggttgt cggcaaggca tcaagaaaca 1865941 gccggccgta accagcggtt ttaatccgtc tgtccaatat aataatcgtt cccttgtctc 1866001 ccgcagaacg cagcaagcgt ccgattcctt gcctgaaggt cagcacagct tccggtaatg 1866061 acactgtttg aaacggattc tttccttttt tgcgggcaag ctcacatttt gcagcatgaa 1866121 gcgggtgatc aggggaccgg aatgggagcc tcacgatcat tactgtcgtc agctcatcac 1866181 cagggaaatc aacgccttcc caaaaatgat ttgttccgag caggatcgcc tgattggatg 1866241 ttttaaaagt cttcatcagt ttgccgggac ttccgcctgt aatcccttgt gccaagagct 1866301 gaatgccgga agcactcatg ttatgcttaa gctcctggtg aacctttttc agcatatcat 1866361 gggatgtaaa cagcacaagg attttaggct gtttttcctt tgccatcagt tcgatataac 1866421 gggctgtatc ctgtataaat tcaggttgcc ctgtatcctg aattgatttc atttcttttg 1866481 gaatcatcac ctgcatacgc tcatcgtaag aaaagggtga ctcaattctc attgtccgcg 1866541 ggaaaaagtc actcagtccc agtcgttcaa tcataaattg aaaagaacct tcgactgtaa 1866601 gagttgcaga tgtcagcacc acactatttt tgcgcgcgaa aaactgatca gccagaagtt 1866661 caccaggttc aagaggctgt gcgtaaatgg ccactgcatt tttcgcaccc tttgcatcta 1866721 tttcaatcca aaccgcttca tcgtcatcag agccaaagaa gagcttctgc aacgtctgac 1866781 agtaatgctg caagcctttc atgcttcttt ggtattcatc ggctaaaaag acggttttgc 1866841 tcttcatgcc cttcaaatgt ttttccataa gggatgactg cgcctcaaaa agctgctgca 1866901 aatgtgtcag catggaacaa agcctctccg caccatctgt taagatcgac cagcttttat 1866961 cctggctttc tttgttcacc ttaaacacta gacggtttaa gtcttcttta ggttttcttc 1867021 gtttgacaaa agaatgtaca gagctaaaga aagcatcact ttctgcttga acgtgctgaa 1867081 gccactcttc caattcgaaa aatgaatcaa ccggcaggct gtttcgctgg aatagctgtc 1867141 tcatcttttt tagaagtccc tgctccttca gagtgccgat tctgctcaat ttcgtatgca 1867201 attctatgta cgtggctctt ttccctaaat gttcgcttgc cgcacgttca aaatggtgtg 1867261 cttcatcaat aataaatgtg ccgctttcgg gaagcctttt tttatggctg ccttcatcgg 1867321 tcagcaaaag agaatgattg gtgatcacca aatcggaacg catagcaatc tgtttggccc 1867381 gctcgtaaaa accgatcaca tgctcactgc gacttctttt ataggagtca tcgtcataag 1867441 ccaatctgtc ccacagcaat tttccgcctg aaggcaaatt cagttccgct acatctcctg 1867501 tatttgtctc tgtcagccaa acaagaagct gtgcctttgt cagtacggca tcataattat 1867561 catcttcttc atgaagcacc tgctcaaatt tatacaggca taaataatgc gattgccctt 1867621 ttaaaatcgc cgctgttacc ggaaatggaa acagatcttg gacaatcggc aaatcctttg 1867681 tgagaatctg ctgctgtaaa agcgtcgaat acgtgctgat tatgaccggc ttttttgatt 1867741 tcttggcaaa aagcgcagcc ggaataagat agccaatcgt ttttccgatg cctggaggag 1867801 cttcaatcag cgcatgctca cgattggcaa acgcatcagc cacctctctc atcatcatca 1867861 tttggccgtc tcttttttca tacccaggca ttaactctga cagcgctttt tcatttcccg 1867921 cttcccagct ttcgatctca aatgagaagt tctcgtcctc atttatacga acatcgatag 1867981 cttcaggttc tctgacagaa aacgaagaaa agcgcgtata gcccggtatc tcggtatgtc 1868041 tgttttcatt aatgaacata tccaacaaat gcgtcagatc actgatgaaa tgctgcgaaa 1868101 gccttcttaa ctgctttaat gtcggataag gaagctgccg cagcttttca aggatttcca 1868161 aaaaaataag ccctgtcact tcagcatcgc tgtcagcccg gtgcggctga tcatgccgca 1868221 gctgaagctc ctcgcttaat tccgtcagct tatacccttc aaatcccgga aaaacaatgc 1868281 gtgagagctc gacagtatca agcacttcac aatctgggag ctgaaagccc gccttatgta 1868341 gctcatactt gacaaatcca aggtcaaaat ggatattgtg ggcgacaaaa taagcgccgt 1868401 caagcaattg gaatacttct tcagcaactg cttcaaatgg ctgttcattc tcgaccattt 1868461 gattagagat tccagtaagc tgctcaataa aagcagggat tgatttattt ggattaatgt 1868521 attttgaaaa ccgctcagta atttgtccat tttcgattac aaccgctgcg atttgtatga 1868581 ttttatcgcc tttcttcggc gaattccctg ttgtctctac atctataaca acgaaccgtt 1868641 gcttattcat taaaatggac acctcaattc ttgcatacga caaaagtgta acacgttttg 1868701 tacggaaatg gagcggcaaa accgttttac tctcaaaatc ttaaaagaaa acccccgata 1868761 aagggggctt ttcttctaca aaattgtacg ggctggttcg ttccccagca tttgttcaat 1868821 tttgttttga tcattcagaa cagccacttt cggctcatgg cttgccgctt cttgatcaga 1868881 catcattttg taggaaataa taatgacctt atctccttcc tgcacaaggc gtgcggctgc 1868941 accgtttaag catatgacgc cgcttccccg tttaccagga ataatatacg tttcaagacg 1869001 tgctccatta ttattattca caatttgtac tttttcatta ggaagcattc ccacagcatc 1869061 aatgagatct tcatcaattg taatgcttcc cacatagttc aggtttgctt ccgtaacagt 1869121 tgccctgtga agtttgccgc tcatcattgt tcgatacata ttatattctc tccatttctc 1869181 gaatatcaat aatgatatta tctattaaac gcgcttttga aaaagcaact gcaacagcga 1869241 gaatcatctt tccagcaatt tcattcacag gctcgagttc cggataggaa taaagctcta 1869301 catagtctat ggttccgcta gtcgtttcaa tgatatcttt tgcagctttt atcaccgctt 1869361 caggatctct ttcaccggct tggacaagtt ccgcacttgt ttgaagggcc cgatacagct 1869421 taggcgcttc ttttctttcc tcagctgtta agtatacatt gcgagagctt ttggctaagc 1869481 cgtcttcctc tctgaccgta tcgacaggaa ccaattcaat atccatgaag aagtcgctga 1869541 ttaacccatc aacaacagct acctgctgcg catcttttaa accgaaatag gcacgagtcg 1869601 gcttgactag attgaaaagc ttcgtcagta cgatcgcgac cccgtcaaaa tgtccttctc 1869661 ttgagcgccc gcataacacg tctgtgcgtc tttctacatg aatcgtgaca ttcttttcac 1869721 cgggatacat atcatgagca tctggcgtaa aaagaatatc gactccggcg ttttctgcaa 1869781 gagctgcatc ccgctcaata tcgcgcggat atgcttcaaa atcttcatta gggccgaatt 1869841 gtgcaggatt cacaaaaata ctcataataa cggcgtcgtt ttcttgtctt gctttgtctg 1869901 ctaaggttaa atgcccctca tgcagaaacc ccatcgtcgg aacaaatccg attgacttgc 1869961 cctctgaatg gtattgtttt atggcttctt tcagctgtga aatatcagta atctgtctca 1870021 tcttattttc ccccgtacaa gccgtcaagc actgtctggt tcatttgaaa ggaatgcttt 1870081 tgttcaggga aagcacgatg tcttacatcc tgaacatatc cgctgattgc tgtttcgatg 1870141 gtttcatcaa tgcgcgtata ttgctttaca aatttaggtg ttctctcaac accgtggccg 1870201 ataatatcat gataaacgag aacttgtccg tccgctttca caccagcccc gattccaatg 1870261 accggtatgc ttagcgtctc ggcaattttg gctgtgagtt ctgccggcac acattccagc 1870321 acaagcatca tagctcctgc ttcttcgcat tttatactgt cttctattaa ttttttggcg 1870381 ctttgttcgt ctttgccctg tactttatag ccgcccagta cgccgactga ctgcggtgtc 1870441 aaacctaagt gactgactac tggaatgcct ccaagcgtca atgcgcgaat ggattcaaac 1870501 acgccttctc cgccctcaag cttcagtgcg tcagctccgc tttcctgaac gatagccgct 1870561 gcatttttca gcgtatcttc cttagacagg tgataagaca taaacggcat atctgtcaca 1870621 ataaaggtat tcggcgcacc ccttttaacg gcttttgtat gatggatcat gtccgcaact 1870681 gtcacaccga cagttgaatc aaggccgagg acgaccattc caagtgaatc accgactaaa 1870741 atcatgtcaa ctcccgcttg ttcagcaagt ttagctgccg gataatcata agcggtcagc 1870801 atgacaatcg gttcttcaga ctccttcatt tttagaaaat ccagttttgt tttcatgttt 1870861 tctcctcctc atgtttagag gagatgatct gccgttttct tctgcaagcc aaaaaacctt 1870921 ccgttacaac gagaaggatt cttcactttc taaagttcgg cgagtttcat ccctctgtcc 1870981 cagtcctttt ttggatcaag gcagactgct gcaatgtcta tctattttaa taataggtgc 1871041 agttcgcagg cgatactgcc caatggaagt ataccaaaat caacgggctt gtaccaacac 1871101 attagcccaa ttcgatatcg gcagaataga tttttttaat gccttcgttc gtttctaaaa 1871161 gcagaacgcc ttcatcatct atacctaacg ccttaccgta aaaggttccg tttaacgttc 1871221 tggctctcat attagtgcca ataccgagcg catagctttc ccataaaagc ttaatcggcg 1871281 taaatccgtg cgtcatataa tcccggtacc gtttctcaaa gcatagtaaa atatgctgga 1871341 tgacgccggc ccgatcaatt ttttccccag cagcttggct gaggcttgtc gcgatgtcct 1871401 tcaattcatc tggaaaatca ttaggctgct ggttaacgtt aatgccgatc ccaatgatca 1871461 ctgaacgtac gcggtcttct tcagcctgca tttccgttag gataccgact gttttttttc 1871521 cgttaatcaa aatatcattt ggccatttaa tatccgtttg gatgcctgct gcctcttcta 1871581 ttccctgcac aacagctact gcagcaagca gagtcagctg cggtgttttt tggagcggaa 1871641 tgtcaggccg caaaatcagg ctcatccaaa caccgtttcc ttcttgagaa tgccataccc 1871701 tagacattcg gccccttccg gctgtttgtt tgtcagccac cacaagggtg ccttccggtg 1871761 cgttattatt cgcgagctca tgagccgttt tttgcgtgct tgaaagaacg tcatggtaaa 1871821 taagatgctg gcccatcact tccgttttta atccaaaacg aatttcgctt tcactgagtt 1871881 ttccgggttt tttgatgagc cgatatcctt ttcttctaac ggcttctact tcataaccct 1871941 ctttccgaag ctcttcaata tgcttccaca cagcagttct tgaacagccg agagcatcac 1872001 tgattttttg gccggaaata aattcattgc cggcctgaga aaataattca ataaggtctt 1872061 ttcttaatgt tgaccgcatg tcttcagcca ctcctctatg tgtttctttt gattggagag 1872121 cttccctgtc acaacagcct gctcgatcca ctgtaattct tctgacaccc attttccggc 1872181 cggccggttt cgaagcgcaa gcaagtcctt acccgtgata tcaagatcct taaggctttt 1872241 gatcggcagg ttttgataag cgtactgaat gtccttcagt ttcttttcat ccagtttttc 1872301 gttttgccga agctgcgata ttttggccgc tgagagcagt gcttttttcc cagctctgta 1872361 cattgtcatt gcgtcaaggc tctggccaaa cgtatcggca atgtgaatgg cttccttgat 1872421 cacttttccc gggagcttcc aggctttcag gaaaaggggc gcgtctttca aaactatgcc 1872481 aaggttaatt aaaagagcag cccaaagctc ctcacgggat gttaaagaga agaatggaaa 1872541 ctcactcgtt gaaatcaggt tttctcgttt atgataaaaa ccaggaagct cttcatacaa 1872601 tctcgtttga atgagtgttt gaagcgcctg gcgagaagct cttccctgca gcaatttctc 1872661 aaactctata gtttttcgtt cgactgaaac atgggagagg agtgattttt ctttcgcaat 1872721 ggcttcttct gtttccggtg aaagcgtaaa gccaagctgg ctcataaagc gtacggctct 1872781 cagcatacga agcgcatcct cttgaaatct atcctcaggc tttccaacgg ttcgaatcac 1872841 tttctgatca atatctttct tgccgccaaa ataatcaagc accttcccgt ccgctgtcat 1872901 ggccatcgca ttgatcgtta aatctctgcg ttttagatcc tcttctaatg atgagataaa 1872961 ttgcacttct gacggtcttc tgaaatcaac ataatcagat tcagtccgga atgtcgtgac 1873021 ttcataggtt tcatcctccc agagcacaat aatggtcccg tgctctttgc ctacatcaac 1873081 agtccgctga aacagccgtt ctacttgatc aggtgccgca tctgtcgcga tatcgacatc 1873141 tccgatcgtt cgtttcatat agctgtcacg aactgcgccc ccgacaaaat aagcctgatg 1873201 gcccgcttcg attaagatgc ggagcacggg aagtgctttg ataaaaactt tttccatgtg 1873261 atcactccgg ttctgctaaa tcggcataaa tctgttcata ctggctgaca atttttttag 1873321 aagaaaattc attttcaagc atctctattg ccgcctttgt aaaacgattg cttagctgtt 1873381 catcttctaa aatgctcatc gcgcgggctg ttgcggccgt aacatcaccg acatccacca 1873441 aaaatccgct cacattgttt tttataacct cagggatacc gccaatgttt gttccaatac 1873501 aaggcactcc gcaagccatc gcttcaagca ggacaaggcc aaagctttct ttttcagata 1873561 gcagcagctt caaatcgcta atagaataaa gatcttcaac acggtcttga tttccaagca 1873621 ttaagacttg gtcttccaag ccatattttc tgataagctc gcaggctgtc gatttctccg 1873681 gaccgtctcc gactaaaagc agcttcgctt tcgttttgcc agcgatattg cggaacacac 1873741 ggatgacatc ctgcacgcgt ttaacttttc tgaagttgga cacatggatg acgacttttt 1873801 catctggtaa aattccatgt ttctctttaa ttgccgctgt gtttttcttc agatacacgc 1873861 gctcgtctat aaagttataa atcgtttcaa tttttttctc cggtttaatt aaatcgtatg 1873921 tttcagccgc aagcgctgag gagacggccg tcaccctgtc tgatgactca atagcaaaac 1873981 ggatcagatc ttttagagac ggatcataac ctaacaccgt gatatccgtg ccatgcaaag 1874041 tggtaacaat gccgatattg cgtttcagca tttgttttgc aagataggcg caaacggcat 1874101 gcgggagagc atagtgagca tggataatgt ctaaattctc ccgttccgcc acctcagcga 1874161 ttttgcttgc caatgtcaaa tcatacggag gatacttaaa aacagcatat tgattaacct 1874221 caacttcatg aaaatgaata ttgggatgat atgtattcag tctaaacgga atgcttgatg 1874281 tgatgaaatg gatttcatgt cccttttcag caagctgctt ccccagttct gtcgcaatga 1874341 tacctgagcc tccaacgctc ggatagcatg tgattcctat ttttagtttt ctcattgttc 1874401 gcccccaagc acatcatgat caagcatcag catccgtttg gaaaagaaac cttcggcata 1874461 ctccacgccc gcttctttac cgtaaagctt ttctctcgct tcaacgattt caatataccc 1874521 attcgtcaga ggagtagaaa cggaatcctt tgacgggata aactggcttt tgtaggcgtt 1874581 gaggctttgt ttctttgcct ctattgtatc cgagatatca ataacaaaat ccggctgatg 1874641 aaaaccattt atcatataat agtaaacctt gctgacttta tgcgccggaa ggcttttttc 1874701 gtctttatat ttatggattc cggcggaaaa gatcgcttct tccaccagtg cagccgcatt 1874761 gccgtgatcc ggatggcgat cctttttata cggcataaaa accgcttttg gccgacagat 1874821 tctgatgaca gtgacaattg accgaattgc ctgatcactc attattaggc cgcggtctgg 1874881 aagcgttagc tgaattcttt tatctgcgcc taatatgcgg gctgcttcag ctgcttcttc 1874941 tttacgcaaa ctgaccgtac cgttagaaga gagttccgct tctgtcaaat cgcatatcat 1875001 tacttttttt tcctgtttga caaacttcgc tattgtgccg cccattccga tctcgacatc 1875061 atcactgtgg gcgccaaaag caagaacgtc agcattatac attcggctct tctccccgaa 1875121 gaaggtcacg gaattcgaaa acaccttcat caagtgtgcg cacaagaatt tccgcagtac 1875181 ccatatttgt ggcgagcgga atggaataca catcacataa acggattaat gccgagacat 1875241 ccggttcatg cggctgcgcg gtcagcgggt cgcgcaaaaa aatgacaaga tcgagtgcat 1875301 tggcagcgat cagtgcaccg atttgctggt ctccccctaa agggccggat tgaaaacgtt 1875361 caatttgaag acctgtcgcc tcatgaattt tcaaccctgt ggttccggtt gcgtatagat 1875421 catgattctt taaaatatcc cgataggcag tcgtaaattg aaccatatcc tgttttttct 1875481 tgtcatgcgc gatcaaagca attttcattg tttatccccc cgtctaatca atgatatttt 1875541 ctaaaccata cacaagctga tcaatcttca tgacttgttc gactgacagt ttaacgcctg 1875601 acatgaaaga agcacggtta taagaatcat ggcgtatctg aagcgtttgg ccatccatgc 1875661 cgaacatgac ctcctgatgc gcgatcagtc ccggaagacg gacgctgtgc aagcgaatac 1875721 cgttttgctc cgctcctctt gctcctggga gaatttcttt ttcatccgga tgtccttgct 1875781 gcttttcttt acggacttct gaaatcattt ccgctgtttt aagcgcagtt ccgcttggtg 1875841 cgtcaagctt ctggtcatga tgaagctcaa taatctcaac atcctcaaaa tagttggcag 1875901 ccatttttga aaatttcatc atcagtatcg caccgagcgc aaaatttggc gcgatgatgg 1875961 ctccgatccc tttttcttct gttaaagatg tgagctcttt taaatcagct tctgagaaac 1876021 cggttgttcc gacaactgga cggactccgt gctctaatgc aatttttgta tgtacttttc 1876081 cgatttcggg cgttgttaaa tcaatcaaga catccggttg tgtttctgta aaacaggcat 1876141 ggatatctgt gtaaatgaaa gcatctgact caacaggcat cacatcagat aatttttgct 1876201 gatcgtatgt atggtctatg gcccctacaa ggtcaaaatg tggtgttcgt tctgccaatt 1876261 taacagcttc ctgccccatt cttccacgcg gtcccgcaat gactaattta attgtttcgt 1876321 ttgacatctt gatctcctct actttccttc ttcttttctg gtccagcgat ctttatctct 1876381 tgtattaaat ttatgcatga ctcggtcgtg agcttcctct aaagagatat caagagagtt 1876441 ggctaaacaa accaatacaa atagcacatc gcctatttcc tcttccatgc ttttatcatc 1876501 ttcagtcgct ttttttggtt tttctccata acggtgattc acttctctgg caagctcgcc 1876561 cagttcttca gtcagcctcg ccatcatggc cagcgggcta aaatatcctt ctttaaattg 1876621 gcctatgtaa cggtctactt cagcctgtat gtctttcatt gttttatcac tcactgaacg 1876681 aaacctccta tcatcctctt acatgttagc taattcagat acgtttgaca aatgtttaag 1876741 cacgtttgct gttttctttt tcatccacta taatataaac gctatctaat ggaaggaaaa 1876801 ggggttttgt gtgatgcttg gagaaattag attaaaaaac atatttttta ttttaatcgg 1876861 agcggcaatt ttttcatttg gcttggttca tttcaatatg cagaacaatc tggctgaggg 1876921 cggttttaca ggtattacac ttttgcttta tgcccttttc cacatcagcc cctctatatc 1876981 gaacctggtg ttgaacattc cgattttttt tattggctgg cgtttgctcg gcaggacaat 1877041 gtttgtttat acccttgtcg gcactgtagc cttgtctttg ttcctcagca tctttcagcg 1877101 atatgaaatc catatgcccc ttcagcacga cttagcgctc gccgctttat ttgccggcgt 1877161 attcatcgga gccggactgg gtattatttt taagttcggc ggtacgacag gcggtgttga 1877221 tatcatcgca cgtttagtga ataagtattt tgggattccg atgggcagaa cgatgtttgc 1877281 tttcgatgcc tgcgtcatca ttttgtcttt gcttacttat ctctcctata aagaagcgat 1877341 gtatacgctg gtagctgtat ttgtagcggc aagattaatc gattttattc aggaaggcgg 1877401 atacgctgct aaaggcgcta cgatcatctc ttcgaaaaac gacctgattc agaaaaagat 1877461 tcttgaagaa atggaacggg gcgtcaccat tttgaaagga caaggttcct acacaaaaga 1877521 ggatatagat gtactttatt gtgtggtgcc gaaaaatgaa ttggtgatgc tgaaaagcgt 1877581 gattaactcc attgatcccc atgcctttgt agcggtaagc gatgttcacg atgtgctcgg 1877641 agaaggattt acgcttgatg aaaataaaaa tccgcttccg cgctgacatg taatagaaaa 1877701 aaggcggctg accgccgccc ctcatcctta tttagggtag tccctttttt tcagcttgtt 1877761 tttttccgcc ttgtactttc tgtaaccgac ataggtaaga gcagtaatga tgatactgcc 1877821 ggttgtaatg atcacccaga gtaaagacgg atcggcatca tcctcctcca ccctgtcaaa 1877881 cacatttttc aggtcatgct gaagaaggga aagccgttca agcttcgtgc tctctgtcat 1877941 ttgctgaaat tcctcttgct caataacatc tatatgtttt ccgactgttt caagctgatc 1878001 ctctgataca tcgattgtaa gactggggta aatcaagtca tataaactga taaattcatt 1878061 ccatttttca tgaaagcttg tgcttccatt cttttggaca tctcgcttca gttcagtaaa 1878121 agcttccata atcggttttt ccagtgagcc ccaaagcggg tcagaccgat tgtcaaccgc 1878181 atccatcagc attctgaact gcgcggctgc tctgagtttt tgtgtgtctg atgtatcagc 1878241 ttgctttaaa ctccgaacca tatcattata gcccaatgtg atttgacgaa tttgggctcc 1878301 cgttagcatg gggtcttgct gttttttctc agcggatttt aatgtttttt caaaatactc 1878361 caagacttga agcgcctctt catatttcgc ctgtcgggtc atttgaaaga ctgtatcgga 1878421 taaatcattc aattcctcga ggcttccccg ctctgcagcc ttggcatttc cattataaaa 1878481 aataagtgca atcaacaaac agatcgtcag ctttcgtttc atgcaggtcc ctcccactct 1878541 ctctccttac agaatatgaa gaaagggaca aggatagacc aacattgtct ttacatcagc 1878601 tcaagcttcg tttgcttttt tgagaccaca agaaagtaag caagcgcgat tgaaaagata 1878661 cttagccaaa atgttccgta tcctatttca gtcatataat cagaaagcat agagtattgc 1878721 ggcatcatat caaacaagta gtcaatgaca tcgttatgca gtgtccagac tgcagcaatt 1878781 gcaagatgcc aaaatgaaaa acgaaaatac ggactgtata atacgccttg aactgccatt 1878841 gcaaaatgcg aagcaattag catgtagccc tcccacggca agtcaccagt tactgcaagc 1878901 acaagaaaat tcatagccac cgcccatagg ccatacttta cgagggtaac tagcgcaagc 1878961 gcctctaaaa gcggagcatt ccgtttcatg agaaaggcaa gcagcacaaa cagaaagaaa 1879021 aacgttgctg tcggactgtc cggaacaaaa atcaggaaac gggccggtgt ctccaaaagc 1879081 tgcggcaagt accaatagta gccgtaaacc gttcccagaa aattaatggc taagacaaga 1879141 ataagcatcg gccgctgccc taatacatat tgaaaccatt tcacatcgaa tcaactctca 1879201 gtctgtaaaa ataatatgtc catataaaaa agctgacgcc gggtcagctt ttgataataa 1879261 aagtatatcc ttccatttga caattcacaa tacgttattt tgcggttgtt tcagaaataa 1879321 attttgcaag ttcttcgagc tgcttatcat ttcctttgaa cacacccgcc ggcattttgc 1879381 ctttcccttc tacagcgatt tttttgattt catccggttt cagcccgctg tcaaccaatg 1879441 aaggcccggc cgctcctccc tgaaggttat ccccatggca agaaatacag ccctgttcct 1879501 taaaaacctt atatccttct gcattggtgt caatgtcggc ttcttttgta attttcccct 1879561 gttcttctgc cttggcccag tcatgagtag caactgactg ccacgtcaaa aatacagcag 1879621 cggaaatggc cagaagcatc ataccgacag cgaccggacg cttccacggc cttctttctg 1879681 tccctctgtc taggaatgga gccaaaagca gggccccaaa agcgagacct ggcataatca 1879741 tggcgccgac cactgtaaag cttccggcgg cgtattcata cttcaacagc tggtataaga 1879801 aaagaaaata ccaatccggc agcggaatat aaccagtatc agtcgggtcc gccatccgct 1879861 ctaaaggcgg ctgatgcaca atcgtcaaaa cgagaaaacc gatgagaaag acagctccaa 1879921 ccatccattc ctttaacaag aaatttggcc agaaagcctc tgttttaccc ggatactccg 1879981 aataatcctt cggtatattc ggcttttttt cagccggtat ccttgagtcg cctacaaatt 1880041 tcatcccttt gccccggtgc atgtcatccc ctccctttta ttcgcagatc aagagtttaa 1880101 agcggtcctg aaatcccctg cttccggatc ataataaaat gtgcagccat cagcccgaac 1880161 aatgcggcag gaagaaaaaa tacatggatc gcaaaaaacc tagtcagcgt ttgggcgcct 1880221 acaatatccg gatgccctgc aaggagcgtt ttaacttgcg ttccgatcaa aggcgtggct 1880281 tcggcgatct gcagtccgac ttttgttgca aacagagcct tcatatccca aggaagcaag 1880341 tagcctgtaa agccaagacc gagcataaca aaaaagatca gcacaccgac aatccagttc 1880401 agctcgcgcg gttttttata cgcgccttgg aaaaagaccc tcagcgtatg taaaaacatc 1880461 atcacaatga ccaggctcgc accccagtgg tgcatccccc tgacaatctg gccgaatgcc 1880521 acttcatttt gcaaataata taccgattcc caggcatttt tgatatcagg cacataatac 1880581 atcgttaaaa acattccaga taatacttgg ataacggtta caaaaaacgt cagtccccca 1880641 aagcaataca caaacgcaga gaaatgatgg gcgggattca catgttccgg tacttcgtga 1880701 tcggcaatat ccctccacat cggtgtaata tcaagccgct cgtctaccca gtcataaatt 1880761 ttgttcagca tgtcaccctt cccccttagg ctttgctttt ccaagataca ggaagccgtc 1880821 ttttacttct tgctcataat gatcaagagg cgcaagcggc ggcgtgccag ggacattggt 1880881 gccgtccttt tcatagagtc cgtaatggca tggacaaaag aatttattcg ggtttttagg 1880941 atcactattc cagttcaccg tacaccctaa atgcttacaa attggcgaaa gtgctacaat 1881001 ttcatccccg tttttgaaga cccaggctga tcttgactct tctgactcat accaggcatc 1881061 gacttgatta attttaaaat caaagcgctg cggctctttt gtcaactcat caacgctgac 1881121 aacctgaacc atatcctgct tccctgtcga ttttaatacc gggtcgagtg cgaagcgaac 1881181 cataggcatg agcatactag ccgccataaa acctcctacg cctgtgagcg tataattcaa 1881241 aaattgacgt ctggatatat catgttttcc gcccatctct tctcccccct ctaagtcacc 1881301 cctgcaaact gactaaaata gaaaatattg caataactct agacaccctc ataatatatg 1881361 aatctctcag caaggtcaat atagccaaaa tattgtttat aaggaaatgt aagtgttttt 1881421 ataaagtgct ccataactgt aacaaaacgt tcaaaatttc agcagtgcgt tcatccaata 1881481 tttttctttt taaagagtca tttaaatgct ctaatggaac agacgatgta acaatcattt 1881541 tgcctaacgc atcctcagct ctccaacttt cgtcagatgt gagcaggaca acatgcggaa 1881601 attccgttat cagctcttcc cgcaaatcct taagcccttg aacggttatt tcatttctat 1881661 caacatatgt ataaggcgga agtaaatata cccgtccctt taactgcctt tcaagttctt 1881721 ctgagagaag ctgcgtaaac tcgcctttct ccgccgccat tttaaaatgg ttattaaccc 1881781 ttatgttaat taatggtatg acagcggtat caatgtaatc cttagcttgt aaatagtcct 1881841 tggcatcagt gattctccac ctcatcgttc tcccccttta cggcaacaag ccttgcaatt 1881901 cactgcaagg ctggtcatat tatgtgagct gatttaattg gcgcgataat tgttcaaatg 1881961 cctctttatc atgacgatct aacgcgtcgt caatgtcttt taataatttt tctctttgga 1882021 atgtggaaat agcgtgctct aaaatctgtt ccgccaatcc ctgatctttt ttattctcaa 1882081 aaaggttttt cggaatatgc gggttggact ccagcaccgc cgcatattca ggtgagctgt 1882141 aagccgaacg gaaattaagc tggataaaca aatcctgctg tttatttaat ctaatatcat 1882201 gaaaagattt ttccgcgtcg gtagtcatga cattctcttt atagaaccgg aacggaactt 1882261 cttcaacaca atgtgttgac attataatgc ctctcgggca aaattcagcc tgctccacaa 1882321 aatgaacctt ctccatgaga gaatcatggc tcattaagta gttcaagatc caaacgcact 1882381 ctcggcgctt taactgataa tggtttaaaa accaacggat aaaatctttt ttctcattga 1882441 cagaaacagg ggtctgcatg taattccctc ctctatcgtt cgtataatct atatacttat 1882501 atgttccaca tgaatggtta atattcctgc ttatctagaa aattcatcct cgattcgcaa 1882561 aatcgtttct tcaagctctt cattggctcc gtccatttca agaacctttt tcaaaagcgg 1882621 cagcgcttct ttttgaagac cttcttctaa taggaagctt gcgtattcat ataagaaatc 1882681 tctatcctcc cggtaatgaa gataggcagc ctcaaaggat tgttttgctt cctcgtattg 1882741 ctctaattca gtatatgcgc ttgcaagata ccaattgtat ttaggatctt cttcaccgta 1882801 gcttcgaacc tcttgaataa gatcaatgat ctgatcataa tcctcttctt tgtgatacac 1882861 ggcaagaagt gtatgaagcg cctcgacaaa gcccggatca agcgcaagcg cctcctgaag 1882921 cagcttcttc ccctcttctg acttcccgat tttcaaggcc attttggcgg cataaaggaa 1882981 aagttctttg ttatattcat catatctgat cccctctttt gccgttttta atgcctcttc 1883041 atacattcct tcagcttcat agcttttcga gagcggcata taaagtgaag tataagatgg 1883101 atcaagctcc tttaaatcag acagctgctt aatagctgtt ttcacaagcc ccgcctgtaa 1883161 ggctgtaaaa ccatagccga aaatcgtatt aggatcagga ttctcatcga cagctttctc 1883221 ataccatgga atggcatcct caaattcacc tgaggcactt aacgattctg ccagtctttg 1883281 atggacatta acgcccccga tctcactctg ctcctcagcc gttgttttaa aatattgaac 1883341 cgcttttgca taggctccct gagcaaagta aagttctccc agtgcaaaat caataacagg 1883401 ttcattgtcc agaatggact ttgcctggaa aagcttttgt tcactgactt cgaataaccc 1883461 ctgcatctga taaagatccg ccataagcag caaactttcc ggatatgatg gatctgtttc 1883521 cggaatagtc tccagcacag cgagggcttt ttcttcttcg tcaatatcta ttaaaagttc 1883581 agcgtagaaa ttcgtcagtt ctgtttcatt tggatataaa tcatgtagat cactaatcag 1883641 tgaaatggct ttttctacat cgccccactc gtaataaagc tgggctgcaa tggctttatc 1883701 ttcatcatgc agctgttttt cagccttcga gagcgtgttg aggccttttt ctgtttcacc 1883761 tgcttcaact aattttatgg cttcttgaat caatgtattc aaatcggacc ggtcctttct 1883821 tttcctatac aacatcaacc atacaaaaaa agctttattt gttcgggtta atcttatcat 1883881 aattcagacg aatgcccccg gcaaataaga tgcttctgta cggaagggaa ttattgagtc 1883941 ttattagttt accaaaagat cttgagatag aaaatgaaaa aaggaagatc gccctctgta 1884001 cagtaaagca gctctttgac ctgccggctt gtaagtaaag cacatccccc cttttcgttt 1884061 ttctatccgt tctataagac aagctatgtt ttttcgcctc gaattatgat ctgcataaaa 1884121 aatcctgaag taaaacttca ggattttttc gaaagcttat ttaaatgctc gaagaaggtt 1884181 ggataagaaa cgtgaatggc atccgtgtgc tcgatttcaa tcggctcctc cgttatacag 1884241 gaagcaatac caagcatcat tccgattcga tgatctccgt ggctggacac tgcagcgccg 1884301 cctttcaacg tttgtttgcc ataaaccttc attccatctg ctgtcggttc aatttcagca 1884361 cccagcttgc gaagctcaga aacaacagta tcaatacggt ttgtttcttt cacttttagc 1884421 tctgccgcgt ccttaataac ggtggttcct tccgcctgag tcgcaagaag cgcgatgata 1884481 gggatctcat caattaaacg cggaatgata tctcctccga tttcaactgc ctttagagat 1884541 gacgtttcta taatcaaatc tccataaggc tctgcaccgc tatcagcaga tggtttgatt 1884601 tcaagttttg cccccatgtt ttgaaggaca tcaataatac ctgtccgagt cggatttaaa 1884661 cctacgtttt tcaatacaat tctgctgttt ggaaccatcg cgccagcagc aaggaaaaac 1884721 gcggctgaag aaatgtctcc aggaacaaaa atatcagcag ctgtcagttt ctggccacca 1884781 gcaatggaaa cactcgtttg atcttcagaa agcttaacgc caaaagcaga aagcatccgc 1884841 tcagtgtggt cccgagattt atggggctct gttacagttg ttgtgccctc agcctgtaat 1884901 ccggccagca aaacagcaga tttaatttgc gcgcttgcaa caggtgatac ataatcaatt 1884961 ccttttaatg aagcgccgct cactgacagc ggtgtaaact ctccgccggc tctgccgtcg 1885021 attttagccc ccattttttt caaaggctca gtcacacgct tcattgggcg tttcgcaatg 1885081 ctctcatctc cggctaccgc gctgtaaaaa ggacggcccg ccaatattcc gagcatcagg 1885141 cgaatcgttg tacctgaatt tccgacatct aaaaggcttt ctggctcttt cagggcatcg 1885201 attccttttc cgtgaatcac gacatcgctg ctgctttgct caatgtgaac acccattttt 1885261 ctaaagcaat cgatcgtgct cagacaatct gctcccggca gaaagttttt aactgttgtt 1885321 gtgcctgccg ctagcgcgcc aaacataaca gagcggtgag aaatggattt atcaccggga 1885381 atatgtattt ctccatgtaa ggtctgcacc ttatctcgtt tcattttttc cacctcaatc 1885441 agcataaaaa gtttcatatt ccgcccgggc ttcaatgcat tgttctgccc ttttgcggtc 1885501 gtcatcagac tgaaaactga tccttaaaat cccgttaata tcctctcgtg tttcgataat 1885561 gcggatattc gtgatactga tgcgctccgc agctaagatc gctgttatct cggatattac 1885621 acccggatga tcgggtacat ccacatataa atcataaaat gcaggtatcg ctcccttctg 1885681 ccgaagcggc agcccgtcgc gataatcctt ggctgtttta aaataacgaa atagattttc 1885741 cgcatcttct tgttctacat atgtacggat cttgtcaatt tcacgaatcc actcatcaaa 1885801 acggtctaag attttatctt tattatgtaa taaaatatcc cgccacattg ccgggctgct 1885861 tgatgcaatc cttgtaatat ctctgaaccc gccggcagca aaacgcttaa caagcggata 1885921 caggttttcc gaatgatggg tttggtgaac aaggctagct gctacaatat gcggaaaatg 1885981 actgattacg cttgtaacgc catcatgctc ctctggcgac atttccacaa aatgggcatt 1886041 cgtccccttc agcaggtttt ttaactgttc cacagcttgt ttgtccgttt tctggcctgg 1886101 cgttaaaata taaaatgcat tttcaaacag gaactccttc gcagcggcca ctcctgattt 1886161 atgtgaaccc gccatcggat gccctccgac aaattgatag cggctaggca gcacttgatc 1886221 agcgtaatca accacttttt gctttgtgct tcctacatcc gtaatcaaaa gctcatgttc 1886281 aattcctgaa tgagccagct cttcaagcat aaccagtgtt tgttcaacag gtgtcgcaat 1886341 gattactgta gctgcctctt tcacaccgct aataaacgaa tcagcacgat cgtctatcac 1886401 gcctaatttt aatgccgcta ccgcctgttc atcagagatg tcgattccga taatccgttt 1886461 gccgggatga ttttttttga tggctagggc aatcgaaccg cctatcaatc cgagaccggc 1886521 gagcaatatt gtatctttca tttgattcat acgtcatcac ctggtttata gactaaagag 1886581 gtgatatttg atcacctctt ataaaatttc agctaaaatg gcaagtattt cttcattttg 1886641 ctcttttgtt ccgatcgtaa tccggagtga tgtcgggaaa cctaatgcgt ttcctgaccg 1886701 gacgatatag cctttttcca gcagagcctg aaacagttca tcagcaggac gtttaaagtc 1886761 aattaacaca aaatttgtct gtgaagggta gcactttaaa ccatgagttt tcgcaaaatc 1886821 ataatactgc tgaaggcctg cattattttg ctcgacacag gaagcaataa acgcttgatc 1886881 atcaagtgct gcaatcgccg cagcctggcc cagacggctg gtattaaacg gctctctcgc 1886941 cggctcaatc tggcgaatca ggttctcgtc agcaattccg tatccgactc tgagcgctgc 1887001 cagaccgtat gcctttgaaa atgtgcgcaa aatcatcaaa ttggaatact tgcttaagag 1887061 cggcacggtt tccgggtaat cctctgctgt tacatattca taatatgctt cgtcaagaac 1887121 gacaaggaca cgagaaggaa cgcgctccag aaatgcgagt aattctcctt cagatgtata 1887181 agtgccagtc ggattattcg ggctgcatat ccaaacgact tgtgtctgtt cgtcgatggc 1887241 ttctaacatg gcgtctaaat catgtgagcc gtcgggacga agtgcaattt cacgtacttc 1887301 agcaccttca ataaccgcat tatgtttata ttgcggaaaa gtgggggcag cagtaaccgt 1887361 gtttgtttta tcgtttaaaa atgcccggca gatgatctgt atgatttcat cagaaccgtt 1887421 gccgaaaata agtgatgttt cgctgacatt gaggtgctta ctgagccttg tccgcaaagc 1887481 ggcgctatac ccgtccgggt aaagggctag ctgttgaatc tcatgatgaa gcgcctcttt 1887541 tgcagcctct gaacagccgt aaggattctc gtttgaagca agcttcacaa ctttatccaa 1887601 gccatattct gatttcactg cttcaatcgg ctttccaggc tgataaggct tcagctgttt 1887661 taaatgttct ttgatacgca aatcagtcac ctcattttaa actgtacaag ccgctaaacg 1887721 ccattgcata atcctcaaac tcctgcagcg cctgatttct cgtttcagcg ctgatgagcc 1887781 ggtcctttaa ttcttctatt tttctgacga gcgcacttcc cactacgaca ccgtcactaa 1887841 tttcattcat ctttatgacc tgttcacggt ttgatatacc gaaccctaca gcaaccggaa 1887901 cagtgctgag attcttcaca gtacgaatga acgggtacac ggatgaattg aactcattgc 1887961 ggacaccggt cacacccaga gaagatacac agtagacgaa cccctcggct tgttcaataa 1888021 tggttttcaa acggctttcg cttgtcggcg caactaaaga aatatacgtc acctcatggc 1888081 ttttacattc ctcttgaagg ctgttgcttt cttctaatgg cagatccgga acaagcagac 1888141 cgtcaatatg attttcccgc agtaaagcga aaaagtattc tttgttcaat tgtaacacag 1888201 gattataata cgtaaagagg ataatcggaa tattcactcc gttttttttc atttctccgc 1888261 ctaattcgat tgcctttacg atattcattc cttgatcaag cgcccgcttt gaagcccgct 1888321 ggatcaccgg accgtctgca agcgggtcag agtatgcaac accaagctcc aatgctgtgg 1888381 cgcctgcttt ttggagtgac ttcgccagtt caatcgaaac ctcaggaact ggatcgcccg 1888441 ccgtaataaa cgggataaac aatttttctg atggttgaag atccaattta aacatgggct 1888501 ttcacctctt cttccaatac attcattaat gtgttgacat ccttgtctcc ccggcctgat 1888561 aaacagacga gaatgagttg accgcgatcc attcctttgg cgagtttgaa tgctttcgct 1888621 aacgcatggg cagattcgat tgccggcaaa atcccctctt tttctgacaa aagctttaat 1888681 gcatccaccg cttcttcatc ggttatactg tcataagtga cacggccgct tttatgcaaa 1888741 tatgcatgct ccggaccgat tccaggatag tcgagaccgg ctgaaataga gtagggctca 1888801 ataatttgcc cgaactcatc ctgaatgaga taagtcaatg aaccgtgaat aacccctacg 1888861 gttcctttcg aaatagtggc ggcatgaaga ggtgtatcaa ttccttttcc tgctgcttca 1888921 gcgccgatca gttcaacatc ttcatttaaa aatgcctgaa acatacccat cgcattgctt 1888981 cctccgccta cacatgccac tactttatca ggcatagtgc cttcaatacg tttcaactga 1889041 tccttcgctt cctctccgat cattttttga aattcacgga ccacttgcgg ataaggatgc 1889101 gggccgacaa ctgatccaat catataaaag tgatcctcac aatgctgaac ccagtaccgg 1889161 atcgcctcat ttgtggcatc cttcaatgtt ccgtttccgc ttgttacagg cactacctcc 1889221 gctccaagaa gcttcatgcg gaaaacgttc agagactggc gggcaacatc ctcttcaccc 1889281 ataaacacag tacaggaaaa gccgaatttg gctgcaactg ttgcagcggc aacaccatgc 1889341 tggccggcac cggtttcagc aatgattttc gttttgccca tttttttagc aagcagcgct 1889401 tgacctagcg cattattgat tttatgagaa cctgtatggt ttaaatcttc tcgtttcaaa 1889461 tagattttcg cgccgcctaa gtattcagtg actcgatcag cgtatgttaa tgcagtcggg 1889521 cgtccggaat agtcctttaa cagcttataa tactcttcac gaaaagcggg atcatccttg 1889581 atttgtttaa atgctgtttg tatttcatct aacggctgca tgagtgtttc cggaacaaac 1889641 tttccgccaa aatcaccgta tctgcctatt tcattcggat atggatacat atcggttcat 1889701 cctttcttct aaaagcctca tcagattctg atctttttgt ccgttttttt caattccgct 1889761 ggcaaggtca attccttctg gctgccattt caataggcgt gtgatgctat ccggattcac 1889821 gccgccagcg ataaagcagc gtttaccaat agccgcctgc tgatattccg gcacacattc 1889881 ccaagaaaat gcaacaccag ttccgcctct agaccctttt acagatgaat caatcacaaa 1889941 gccgtcaaca ttatctttaa agcgggctat ttcttgagtt gtgttatctt gatggtgaag 1890001 cgccttccat atttcacagc ctgtcagctt gcgaagagca gcagcatccg ccggtttttc 1890061 atcaccgtga agctgaatga cgtcgagctt caagctcttg gcaatacgtg acatcgtctc 1890121 tattgattca ttaacaaaaa cacctgcaac ctgtttttcg acacgaactt ggttcagcca 1890181 ttttttcaca tcttccggag atacttttcg tttgctttca gcaaaaataa atcctaggta 1890241 atcagcctgt gattccgccg caagctgcaa atcctttagt gaccgaatac cgcaatattt 1890301 taatgccggt ttcttcacaa cctcactccc taaacaaagc atggattgct ttacgctgag 1890361 aagtttgtct catcaatgat tcaccgataa gtacagctcg tgctccatgt tctttgacaa 1890421 atgttaaatg ttctaaagaa ccgattccgc tttcgctgac aagcagtgat tctttcggag 1890481 caagagatgc gatttgttct gtctgcatga tagaggtttc aaaagttttt aggtttcggt 1890541 tgtttatgcc gagaatatca ggcgtgaata ctttcaatat ttgttctagc gttgttgcat 1890601 catgaacctc cactaacacg tccatctcct tttcacctgc ttcaagatat aattcatgaa 1890661 ggtgtaaggg atcaagcact tcgccgatta acaatatggc atccgctccg attcttcttg 1890721 attcctccac ttgaagagaa tcaataataa aatcttttct gagtacaggt atcgaaacag 1890781 cgcgctttac gtctgataaa tagctgtttt ccccttgaaa aaacggggtg tctgttaaaa 1890841 cggaaagcgc atctgctttc gcagtttcat agtcttttgc aatccgcaca ggtacaaaat 1890901 tctctttaat aagccctttt gacggcgacg ctttcttcac ttcagcaatc aacccgataa 1890961 accgattcag gcttgccagc gcctctttaa atgaacgttt ttcgaaaggc tgctctaccg 1891021 gcagaaccag tgttttcact tcttctttct tttgtttgat gattttttca agcatagatc 1891081 tcttcctctt tctgctttag tcgttcaagc tgcgcggcag cgcctccgct tgtaatcgtc 1891141 tctaacgcca gctccgttcc ttccttcagt gaggcggtaa ttcccgccgt gtaaatcgca 1891201 gcacccgcat taaaagccgt aatagataaa gcggaactgc tgcttttatt ttcaaaaata 1891261 ttctgaatga gataagcgct ctctttcgga gactgcacct gtaaatcttc aagtctgcca 1891321 tttgtgaaac cgaaatcttc gggtgaaacg gtatactccc ggcgctctcc gtcctttaat 1891381 tcaatcacgt cggtcggtgc tgtaattgaa agctcatcta aaccgtcacg gcttgataca 1891441 aacataacgt gcttcggctg aaacgtctcc agtgcgcttg ccatcagtcc agctttttca 1891501 acagaataga ccccaatcac ctgacgcttc gcctgtaaag gattgctgag cggcccaagc 1891561 agattaaata ccgttctgaa acctagctct tttctagtac ctgctacatg tttcatagac 1891621 gaatggtaaa gcggcgcaaa aagaaatccc atgttgtttg tttcaatgct gcttttgacc 1891681 ttttcgggag tggtttgaat agaaacctct agctcctcta aaacatcagc gcttccgctt 1891741 ttagaagaga cagagcgatt gccatgctta gcgattttcg caccagctgc cgaggcaaca 1891801 attgccgagg ccgttgagat attaaaagtg gaaataccgt ctccccctgt tccgcatgta 1891861 tcaacaatat caggaagtcc atcgactgta agagcgtgtg cccgcattgc cttcacaaaa 1891921 cccgcaagct cttctggcgt ctccccccga tgagcaagaa ttgacaatat cccccccatt 1891981 tcagaaggag tcatttccgc tgccatcatc atattcatca gcgtttcagc ctcaccggca 1892041 gtaagggttt ttccgtcaac gcacaattgt agaaatctgt tcatcagctt tatcctcctt 1892101 gctatgaaac atgtcttctg caatatgaat cgttttcagc agcgcaccgg ctttattaca 1892161 gctttcttcg tattcggctt ccggaacaga atcagcaaca atgccagcac ctgcctgtat 1892221 cgatgcaaca ccgttcttta cactcatcgt gcgaatcgta atacaagagt cgatattccc 1892281 gtcaaaccca atgtaggcaa tacaccctcc gtatgtctct ctcggtgttg gctcgagttc 1892341 ttgcaaaagc tgcatggcac ggattttggg tgcgcctgtt aaagtccccg ccgggaaagc 1892401 agacatcagt gcatcgacag gatgaacccc ttttttcaat cggcctgtaa ccaccgagat 1892461 aatgtgcatg acatgtgaaa aggaaacaat ttttgtgaac tccggcacag aaacagaacc 1892521 atactctgct actctgccga tatcgtttcg ggcaagatca acgagcatgt aatgctccgc 1892581 tttttctttt tcatccttca tgagctcaac cttcagtctc tcatcttcag ctttgtctgc 1892641 accgcgtttt ctcgtaccgg caatcggatg gatttctaag tgcccgtctt gaacgtgtat 1892701 taaccgttcc ggagagctgc cgactatttc tctgtctagc agtttcatat aatacatata 1892761 cggcgaagga ttgacgatcc taagcactcg gtataactca aaagcatctg cttttatcgg 1892821 cacctcaaat ttttgtgata aaacaccctg gaagatatcg cctgctttta tatagctttt 1892881 gattttttct acatcagcca taaaagccga tttttcataa ttagaagata ctgtctcaaa 1892941 gctgggtgtc ttgtatgaat cagcagaaag aaacagctct tttatgtttt tttggtccat 1893001 cattttttca atgagatttt gaagctccag atgattttga tggaatacat ccattttttc 1893061 gttttttgtt tcctctccag tgagccttgc atattggata aagtggacgt ttttggtttc 1893121 atgatcatac gcaattaatg tccggcaaac aaacagcata cacttttcca tgtctgtttc 1893181 tttggtatgc gaaggaacag aaggctcaat cagcgggatc atatcatagc ttaagtaccc 1893241 gacagctccg ccgacaaaag gaatgccaag ctcaggtgtt ttgattttgt atgtggtatt 1893301 catccagttc agcacttctt ttagttcatt tcctgtgtaa agagatttgc tgtcctgatc 1893361 agcggccgaa aaacggccct gctcttcttt aattgtgaga aatggattca ggccgataaa 1893421 cgaatatctg gaccaagtgg atgtatcgtc cttgctttca agaagatacg taatctccct 1893481 gtcaagcttc tctatcattt gaatgggtgt cagtgtatcg actgtgaagg tctccacaat 1893541 cggtatcgtg tggtgggaca agctgtcctc taaaaatgcg gaaatgtttg attggaaatt 1893601 cattgctctc actccttatg gcaaggagaa tgagaagatg gcatgagagg ataaaatact 1893661 atataacaaa taaacccaaa agaaagactt cttttgggta gaataaacat aatgtctcag 1893721 ctcaactaaa ctcattctct gctaccctat tctctaactc aactcattct aattgcttta 1893781 tacacactct tgtgtatttc taagctgttc ttatcgtatt acaattcagt attttttgtc 1893841 aatgataaat cgggcctcaa tacgacaact ttttctaaat atacatgtct gatctgatcc 1893901 tgagggacat ctgtctggac cgtcatcatg actcttatgc actttttcag accgcctgtt 1893961 acgtccattt cctgcataca tgttaccggt acatactgcc atcctgaaag ctcgcgaaca 1894021 gcttttgccg ggaaaacagc gtgcaaatca ggtgtagccg acagaagcat ttgaacaaca 1894081 tcttccggtt ttgtatgatt ttcttctatg attttctcta acagctgttt agttttttgt 1894141 aaaatttctt cttcagtatc ccgttcaact gtagttgctc cgcgaattcc gcgaatcatc 1894201 atgatgtctc ctccaatcgc catttgttca gccagctctc aagttcattt ctggaaaatg 1894261 tatgatcagc aactttccct aattcgttga gcacaataaa ctgaatcttc ccgccacggg 1894321 ttttcttatc attcatcata cggttcaaga gaaccgaagt ttccgtctct tttctgattt 1894381 gacttggata acccaggctt tttagccagc tgaccaaacg ttttctgtcc atttcacagc 1894441 ctacagtctt ttcgcttata tataaagcaa actgcattcc gagggctacg gcatcaccgt 1894501 gagtgatctg cccatatcca tattccgcct caacggcatg gccgagcgta tgcccaaagt 1894561 ttaagtaagc tcttatcccc tcttcttttt catcctgctg aacgacagac gctttaattg 1894621 aaatgccttt aaaaatcatg tcattcagct gatcattagt gatatcacgc agtgagtgga 1894681 tattcagcag ctcctccaga aacgctctgt catagataaa agcgtgttta atcacttctg 1894741 ccattccgga cctaagctct ttttcaggca gagaacgcag gaaatctgta tcatagagca 1894801 cggctttcgg ctgataaaac gcaccgatta gattttttcc aagcggatgg ttcacggcta 1894861 cttttcctcc gactgcgctg tcatgcgcca agagcgtcgt aggcatttgg atgaaatcaa 1894921 tgccgcgcat aaaagtggca gccacaaaac cggcaagatc ccctacaaca ccgccaccga 1894981 atgcgatgat gcatgaggag cgatccatat gaaaacgaat cgcttcactc tgcaattttg 1895041 tgtacatgtc catggatttt gcctgctctc cactcggtac cgtcactttt ttcacaggcc 1895101 atttttcttg cagcaaatgg agcatttcat caccatacag gcggtccact tcttcatccg 1895161 tgacaaacat aatccttgtt aaaggcctgt ttaaagaggt taatagttcg caagcctttt 1895221 ttctgatacc ttgtccgata aaaacaggat atgacgagga agcagtttga acatgcagtg 1895281 tcttcattaa aattccctcg acagttttct catattctcc acattttctc taatgcggtc 1895341 aatttgatct aatccgaatt gttcaacgac tgcgttcgca atttcccaag cgacagccgc 1895401 ttcagcgact acacttgccg caggaacagc acagctgtct gaacgttcaa tgctggcaga 1895461 aaacggttct ttcgtttcaa tatcgacact tttcagcggt ttatacaaag tcggaatcgg 1895521 cttcatgact ccgcggacaa caatcggcat ccctgtcgtc atgccgcctt ccagtccgcc 1895581 aagtctgtta gtagcacggg tgtatccttt ttcctcgtcc caaatgatct cgtcatggac 1895641 ttcgcttcca tttcgccctg ctgcctcaaa tccgatgccg aattccacac ctttaaatgc 1895701 gttaattgac agaacagcgg cagcaagctt gctatccagc ttgcggtcat aatggacata 1895761 gctgcccacg cctaccggca ttccctcgac aatgacttct actattccgc cgatggaatc 1895821 tccgtttgcc tttgcttcat caatggcagc catcattttt ttgcctgcct cttcatcgta 1895881 gcatctgaca ggagactctt ccgttacacg ctgcaagtct tcaattgacg tatactctgt 1895941 tttttcagct ttaacagcgc caatttgcaa cacgtggccc gccaccttaa tgccaagctc 1896001 agaaagaatc tttttagcta cagcccctgc cgccactctg acagttgttt cccttgctga 1896061 agaacgctca agcacatttc tcatatcacg atgattatat ttaattgcac cgtttaagtc 1896121 agcgtgccca ggtctcggtc tggaaatctg gcgcttcatt tccttttctt catcttctgt 1896181 aatcggagcg gcgcccatga tttttgtcca atgcttccaa tcgttatttt caactacgag 1896241 agcaattggc gaaccgagtg tacgtgcatg gcgcaccccg ctcataattt tggcctggtc 1896301 tttttcgatc tgcatgcggc ggccgcggcc gtgtcctttt tggcgtctgg caagctcaaa 1896361 attgatatct tcctccgtta tgtaaagccc ggcaggtaca ccctcaataa tggttgtcag 1896421 ttgggggccg tgtgattctc cggctgttaa atatctcatg acttcttctc ccttcatcgc 1896481 attaacgctt ttaagtaaga ctactataac atatttttca gcaaaaagtc agtctatctt 1896541 ttttgataaa agaatgtatc ggctgggact aggccaaatt tctcgggatt gaagatttgc 1896601 tcggtgctgc cgacaaaaag aactccattc ttcttcaagc tatgtgccat ttttaaatac 1896661 agctcttcct tcgcgctttc tgtaaaataa ataaatacat tgcggcacac gattaagtca 1896721 aagtcttgtt cataacgatc cgccagcaaa ttgtgctttt tgaatgtaat attctttttg 1896781 atttccgttt tcacttcata acttctattt gcgttttgcg taaaataacg atctttcaca 1896841 gatagcggca cttcctgtaa agaccgctcc tgataaacgc cttttttcgc tttttccaat 1896901 gctttttcat caatatccgt cgctaaaatc tgatagcccg gaagaccttt ttgctggtcc 1896961 aaaagcatgg caagcgtgta tggctcctcc cccgttgagc aggcggcact ccaaattttt 1897021 aaaggcctag aggtcttgat taacggcaga attgcagtct caagaacttc ccatctttta 1897081 taattacgat aaaattctga aacattgatc gtcattctgt ccaatgtttc atttaagaga 1897141 gcttgatcct tttccaatgc cgcagcaaag tccttaaagc tttggaaccc ctttttctca 1897201 taaagtgacg ttagccttct cttcatttgt gcttctttat atagtgttaa atcgactccg 1897261 gttaattgtt tccatttcgt tgtaaatacg ctgtatgtat ccatctctac tctcccagtc 1897321 tcgctgtctt tttgtcctag tatagcttgt tttatcagga aattgtattg tttcaataaa 1897381 aaaatcagct tttcagctga ttttagatcg ttgggaaagg cagaggtctg atgcacactg 1897441 ccattcaacc ctttattcac tttaatgtaa acctttacaa aacagaacaa aaaccggcgg 1897501 cgttatatgt tgccggctct gttgcttatt ttcacaatga ttaatagatc cagcctgcca 1897561 taagctgctg atatgatact aattcttcat tcttaaagaa aatgttaatc tcgcgttctg 1897621 cactttcgag agaatcagag ccgtggatga tgttttttcc gacaaacatg ccataatccc 1897681 cacgaatcgt accaggtaaa gcttctttag ggtttgtttt cccgatcagc tgtctcgtca 1897741 cttcaatgac attttcgcct tcccacacca ttgcgaatac aggtcctgaa gtaataaact 1897801 caacgagctc tccgaagaaa ggcttacctt gatgttcggc gtagtgtttc tcagccattt 1897861 gttcagtcac tctcattaac ttggcgccag ctaattgtaa gcccttacgt tcgaatctag 1897921 ataaaatgtc cccaatgagc tgacgttgga caccgtctgg tttcaccatg ataaaagtct 1897981 tttccatcat attctccacc ccatcattat gtatgtatag gctttcacac tgcacaccga 1898041 aatcgtaaca tctttctgat aattaatcaa tccggggcgg agaaatttct taatatctac 1898101 aaaaattaaa attttctttt accgatatat tttgcgatgg ctgcaagaga cgagcgtgcg 1898161 cgccctcgag gaagcgtgtt taatttctga aaagctttct gcagatacat ttcgcttact 1898221 gccatagatg cttcaattgc atctgttttt ttgatttctt caatgattgg ttcaagctgt 1898281 tcctgcgttg tctcactgtt aatcaattta agctggtttt ttaatgcagg atttttcagg 1898341 gcatacagca ctggcaatgt gacgtttcct tgaagcaaat ctcctcctac gggtttaccc 1898401 agctcttcct cagttgaagt aaaatcaaga atatcatcaa taatctgata agacatgccg 1898461 acgtaatacc caaaccagta caatgcctta tgaatcttct catcagctcc agacgcaatg 1898521 gcaccaagct ggcagctgac cgcgatcaag agagctgttt ttcttttgat acggcggaga 1898581 tacgttctga gattttgttc catgttgtat ttgtctttga tctgctcaat ttcccctaga 1898641 caaacttcaa cgatcgtctg tgacaaaatc ctatgggctt tcggttcgtt aattctcgtc 1898701 atcatttcaa gagatcccgc aagcatataa tcgcctgtgt acatcgcaat acgattgtcc 1898761 cactttgctt tgattgtcgg ttttcctcgg cgaagctctg catcatcaat gacatcatca 1898821 tgaaccaaag atgccatgtg aatcatttcc agagtgacgg cgacatattt aatcttatta 1898881 atatcataat cgccaaacat gccagaaagc agcacgaaaa caggccgaat acgtttccct 1898941 ccggcctgca gcaggtgaag acctgcctcg cttaaaagcg ggtaatcgga acgtacggtt 1899001 tgttcaagtt ctctttcgat tacatcaata tcgtcattta aaaaagagta ggccatttta 1899061 aatttcatat cattcaccca aacatctgtg ttttcatttc catccgatat gcgtggcagc 1899121 gactccgcca gtaaacgaat gatatttaac atttttcagg cccgcctctt caaacaggcc 1899181 tgccagttcc ttcattccag ggaaatctct ggctgattct tgaagccaag aatattcttt 1899241 atagctcttc gcaaacagtt tcccgaaaaa cggcataata tacttaaagt acataaagta 1899301 agcctgtctg aatccgaaca tttccggctg ggacgtttcc agacatacca cctgcccgcc 1899361 cggcttcact acacgtctca tctctttcag tacagtcaag taatcaggga cattgcggag 1899421 tccgaagcca atggtgacat aatcaaatgt atcatcatca aaaggaagct ccatcgcatt 1899481 tccgtgcagc agttcaattt ggctgaatcc gccgtctttt actttctgct cgccgacact 1899541 cagcatattt tcactgaaat ccaagccctt gatctcgccg cttttgcctg ccgcttttgc 1899601 aagagcgatc gtccagtcag ccgttccgca gcagacatca agtgcttttg cgccttcctt 1899661 tacattcatg atgcgcatcg ttttgtcgcg ccatttttta tgctgctgaa aactgatgac 1899721 agagttcatt tggtcataat ttttatatat tttttcaaat actccgtgta cgcgctgttc 1899781 ttttgagtcc tgcataatgg tttacccttc ttccactttc tgatgatagg tttgatcttg 1899841 gctgattgtc ttcagacggt ttattaaaat gttctgaata ggtgaattta gaggcagaag 1899901 tgactcaatg ctgtttttcg cttttttaaa acaatcttct aatatctctt cttttgtttt 1899961 tcccagctgt ataaaactgc cgatcacatc cagaaatgca tcatttccgt tcataagccg 1900021 cttaaataca aaaaaatcac tcgacagctt tttccagcgc gggaggttga agtgttccgc 1900081 cacacgatgg aataaagctg attcaacgat gccgacactt tcgaaaaaat cgttttcgtc 1900141 cttgaaagaa cggtcataca gacgaatttt atgttcgttg atttctttaa tggctgtagc 1900201 aagcgtccga atcatgtaga tatccttcat ttcagatagt aaagagtagt acagcccgct 1900261 gaaataatcg cccgcgagaa cagtcaattg gcggtttttg ttttcgtctc gttttatgac 1900321 tctagctgtc gtcacttcat catgggtatc aagggcgctt tgtacaagca tcgctgttac 1900381 aatataattt tctctgtcgt tgttttttat gtcggcttct tcaaataaag catgaaaaag 1900441 aagaagctta tcctcatcaa ttttcggcgc agaaatatgc ttcgctaaat aaggatgaga 1900501 cagcttttgt tttaatttcg tgttcagatt ggctaaagtt ccgtagatgt cttgcaaaaa 1900561 tatcaccctt gtccccaaat tcacatttat ttcttaatct atgtatgagt tttatctttt 1900621 cattcgctta cgcaggtatc attatagcat aaaaaaaaga aattggctgt atcctcccgc 1900681 tgtttgcgag catttgcttt taacagcggg gacagccagc ttattttttt tcgcttttca 1900741 tttctccgta cgcggtttga atcagtgcct ctcctctgac tttaatggca gaagtatgct 1900801 ctgtaaactg agcgatgatc acttctccct tgtcgagttt ttcggaatgg tgaaactttg 1900861 tgtctgttcc tcttgtcagg ccgatcacat tcactccgtc ctcaacggct ttaatgacga 1900921 caaaatcact tgaatgcttt tggttcattt atagcaccct ctatctttat tagtcctggc 1900981 gtttaatatg ttccaatact tctgcacggg cagcggcatc atctttaaaa acgcctctga 1901041 ctgctgaagt cacagttttc gcacccggtt ttcttacacc gcgcatcgtc atgcacatgt 1901101 gttccgcttc aaccactacc attacgccat gcggatcaag cgtttctacg atgctttctg 1901161 caattgtaga agtgatgcgt tcctgaagct gcgggcgctt tgcaacggct tcaacggcac 1901221 gtgccagttt gctgagtcct gtgacctttc cgcctcgcgg gatatatgca acatgtgctt 1901281 ttccataaaa gggaacaagg tgatgctcac acatagaatg aaacgctata tcttttacaa 1901341 gaacaagctc ctcatggttt tcaccgaaga tagtctggaa atgttctttt ggatcttcat 1901401 tcaagccgga gaatacttcg gcatacatct ttgcgactct tttcggagta tcaagaagcc 1901461 cttctctatt cgggtcttct ccgatcgctt ctaaaatttg acgaacagct tgttcgattt 1901521 gctctttatt aacttctttc atgttctatg tcctccacca atgaatacat ttaatttcga 1901581 ttctagcaca tatgccccgc taaaagcaaa gtgaatgccc tgtcaggaag cccatgctct 1901641 tgaaatatga aaagcccctt agaaaggggc ttttctgtga agaaataaag tgtatgtaag 1901701 ctagatgcat acacgatcta tattcacaat tattttccgg caactgcgtc tttaagcgct 1901761 ttacctggtt tgaaagcagg tactttgctt gctggaattt cgatttcttc acctgtttga 1901821 ggattgcgtc ctttacgtgc agaacgttca cgcacctcga agttaccaaa accgatcagt 1901881 tggattttat caccgttttt aagtgcatct aagatcgtat caaaaacaga gtcaactgct 1901941 tttgtagcgt cttttttaga caattcgctt gcttctgcaa ccgcattgat aagttctgtt 1902001 ttgttcatgc ctttcacctc ctcccaaaag gatacattca gttcgtttat tatcatttct 1902061 tcacagttca gtctgattct aaacctgtct cagaaaaaaa tgagagcaag taagagaaag 1902121 acaattaaac ggctttttaa gaaaaactgc actctgagga atgtttgtcc aacaaagtga 1902181 agaatttctg tatgtagagt aacacatata aaaagccata tcaagcattt taaagcgtca 1902241 atcccttgct cgtcaaggat ttaaggtgat ttaccgaacg aatattcctt tttttccttt 1902301 tttcatccta ttccttgatc cttttccatt attaagagca aagaaaaaag acctcccatt 1902361 ctataaagag gtctaccggt attacaggat gatggcgatt aagccgccag agccttcgtt 1902421 tatgattctt tctaatgttt cttttaattt ataccgtgcg ttttcaggca tcaatgacag 1902481 ctttgcctga atcccttctc tcacaattga gctcagcgac cttccgaaga tatcggaatt 1902541 ccagatggag agcggatcat cctcaaagtc ctgcattaaa tagcgtacaa gctcttcact 1902601 ttgtttttcc gttccgataa tcggggcgaa ttcgctttcg acatctactt tgatcatatg 1902661 gatcgacgga gcgacagctt tcagcctcac accgaatcgc gagccctgcc ttataatttc 1902721 cggctcatcg agactcatat cagctaaagc aggcgctgca atgccgtatc ccgtctgttt 1902781 gaccattttt aaggcatcag acacttgatc atattctgtt ttcgcatggg cgaagtcttg 1902841 catgagctca agcagatggt ctcttcctct gatttcgacg cccacaactt cttttaggat 1902901 ttgatcatat agatgatcag gcgcgtacaa atcaatttct gccacccctt ggcccagctc 1902961 aattccggct aatccggcac tttcaatgaa ttcaaactcg ctgaattggc cgacaaccct 1903021 gtctacgtcc cggagccgtt taatatcctt aaccgtttcc ttcacggact cctgatagct 1903081 ttcacgcaac caatggtttt ctttcagcac cattacccag cttgggagat tgacattcac 1903141 ttctagcacc ggaaactcgt agagggcctc tctgagcaca ctcagcacat ctgattcccg 1903201 catgctctct acactcattg ccaataccgg gatatcatat ttttcgctta aatcctggcg 1903261 catggcttcc gtttccgggt gatacggcct gactgagttg atgaccataa taaaaggttt 1903321 gccaacctct ttcagctctt caatgactct ttcttcagcc tctatatagt cacttctggc 1903381 gatatctcca atggtgccgt ctgtcgtaat gacaactccg atggtcgagt gttcttgaat 1903441 gacttttcgt gtgccgattt cagcagcctc atgaaatggg atcggttctt cgtaccaagg 1903501 cgtattgatc atccgcggcc cgttttcatc ttcatatcct ttagcgccgg gcactgtgta 1903561 acctacacaa tctactaatc ttatattcac atcgagtccg tctgacacat gaacagacat 1903621 cgcctgattc ggaacaaatt taggctctgt agtcataatg gttttgccgg ctgcgctctg 1903681 cggcagttca tcctgcgctc gggcccggtc tgcttcgtta ctgatattcg ggagcaccac 1903741 aagctccata aattttttaa tgaacgtgga ttttcctgta cggacagcac ctacgactcc 1903801 taagtatata tcgcctcctg ttcgttcagc gatatccttg aaaatatcga ccttttccaa 1903861 gtgatcccct cccggacttc ctatcctttt caattttatt aagctctttc aatcaaacac 1903921 aggacactat atgtgtatga cgttgtccta tttgaatatg acatctttag aaaatttctc 1903981 atcctcaatc tattaatata aaaaaacctt tctccctatt tgtatgcaag ggagaaaggt 1904041 tcattccttt ttcatatcat tttctaaaaa aacaggttcc tgtttgtcat ttaccgtata 1904101 ttttacagaa aacgcgggga caaagggggt ttcatgccaa atcatatcct ggatttcagt 1904161 cccgggttta aacgtttttt tgcttttttt gaggcaagaa gccagctcag tccggtaatc 1904221 ggcatatatt tctccgtctc cgtcaatcat aagcggcaag gaattccctg agattgggct 1904281 tgtcactgta agagagctgc catccccaag cttcttctca tcgagtgtaa ataaatcacg 1904341 agatagcaca tccttgtaag gcggatattg atgctcctga cgatacattt ggatgcgcaa 1904401 tttcacatcg cgaatttttt ctgccatctt tagatcaatt aatttaacag tcggatcgtt 1904461 ctctacgtca acaagcacgt attgatagtc tcccccgctt tcaaatgccg tacttggagg 1904521 ttcagctatg tatcttggcg ctaaccggtt aaagtctatc ggatattttt gatatagcgg 1904581 tgtcgacata tctttggttt gaataggaag cagccctcca tttgcctttt gaaattcatc 1904641 aacagcagat tgaacctgct ttagctggtc ttgataagga atggcatgca cactgctttt 1904701 ccgttcattt ggatataaac atccggataa aaacacgact gccgcaaaaa tgattgcgca 1904761 cttcagttta cccatacagc acttcctttt acagctttat tcattgacag ggccgctaaa 1904821 aaccacgaca aacacaataa ttccagatat gagcatacac atgtatgcga atgatgaaat 1904881 cgcaatcttc aaaaaacggt tttggcactt aaagcggctt aaatagatgg aagctacagc 1904941 cagaaacatc agacccatgg accctagagc aaaccacatt ttcatcaatg ccagattcaa 1905001 tgacgtgcgc ctccccgata tgtaagatat aagcgttata ttatatttta atatacagcg 1905061 ccggaaaaga tcaaccagat tttccatcca ttgatagaac aaaaaaactg aagcaaagag 1905121 ggggaccttc gcttcagtca acttgactat attcacctgc acgtttaaga aacactctct 1905181 tggacttcga tgctatagta tgcgacttgg catacagatg catcctctat tgcctaaatc 1905241 ggcaaaatgt ttcaggagat cccaagactt gggtgttctt ctgtttttcg ggctttcgtt 1905301 caattaagat atgcgattca ccatttgatt gacactttta cttcacttga ttttcaaacg 1905361 tatttaccaa atcctccatc tcgtgggttt tccctctcgc cattaaagat tcaacagcgg 1905421 tttccacttt ttgtccgttg aataggacct gatggagagc ttctgtaatc ggcattttaa 1905481 catcatattt cttcgaaagc tgataagccg ctttcgtcgt gcggacgcct tcgactacca 1905541 ttcccatctc ttcaagaaca tcttcaagct tgtacccttt tccgagcaaa ttgcccgcac 1905601 gccagtttct ggaatgaaca cttgtgcacg tcacaatcag atcgcctact cctgtcaatc 1905661 cagagaacgt caagggattt ccgcccattt tcgttccgag tctcgcgatt tcggcaagtc 1905721 cgcgtgtaat caaagcagct ttggcattgt caccgtaccc taaaccatct gtaattcctg 1905781 cagcaagggc aataatattt tttaaagccc ctccgatttc aactccgata atgtcaggat 1905841 ttgtgtacac ccgaaaattg tgattaataa atagatcctg cacctcttct gctgccctca 1905901 tgctctttga agatgcagta acagttgtgg ggtgccgcag ccctacttct tccgcatgac 1905961 tcgggccgga aaggacaacg atatcttttc tgacatcact cgggagctca atttccataa 1906021 tttcagaaat gcgcagaagt gaatctggct caataccctt gctgacatga acaaagactg 1906081 cctttttcgt tataaaaggg acagcctgtc tcagcacttc ccgaattgct tttgtcggga 1906141 ccgcaacgat aatgacatct gcgtctgaaa cagcctcttt catatctgtt gttcctttaa 1906201 tggatgtaga cagcttaaca ttcggcaaat aatctttgtt ttcatgcaac tcattaattt 1906261 gatgaattaa atctgcacgg tgagcccaca cacacacttc atttccatta tcagttagaa 1906321 ctaaagccag tgctgttccc caactccccg ctccaagcat tgtgactttt ttcatgtttg 1906381 attcacacct ttttattttc tagctcttgc aaatattttg attggtgtcc cctcaaaacc 1906441 gaacgcgtct ctgattcggt tttctaaaaa ccgttcgtat gaaaaatgca tcagttccgg 1906501 atcgtttaca aacacaacga agcttggcgg ctttaccgac acttgagtcg catagtaaat 1906561 tttcaaacga gaaccgttat gagtcggtgt cggattcatt gccacagcgt ccatgatgac 1906621 atcatttaag acgtttgttt gaactcgaag tgaatgattt tcactagctt tgataatcgc 1906681 aggcatcaga gtatggatcc gttttttcgt taaggcagac ataaatagga ttggcgcata 1906741 atccagaaat tgaaaatgat cgcgaatatt ttcttcaaat tctttcatcg tgctctcatc 1906801 tttgtcaaca gcatcccatt tgtttacgac gatgacgacg gccttgcccg cttcgtgtgc 1906861 ataaccggcg atacgcttgt cctgttcaat aatgccttct tcgccatcca gcacaaccgc 1906921 cacgacttct gagcggtcaa tcgcttttag cgcccgcagt acactatact tctcagtcgt 1906981 ttcatagact ttcccttttt ttcgcatacc tgcagtatcg acaatgacaa actcctgctg 1907041 gttgtaagta aatgacgtat caacagcatc tcttgtcgtt ccagccacgt tgctgacaat 1907101 aacgcgttct tcgccgagca tcgcattcac aagtgaagac tttccgacat ttggacgtcc 1907161 gatcagacag aattgaataa cttcttcatt gtatttcgtt tcaggaatgt ttttaaaatg 1907221 ctctgcaacg gcatccagta aatcacccag tccgagtccg tgtgttcccg aaattggata 1907281 cggctcgcca aagcctagcg aataaaaatc ataaatattc gctctcattt ctgtgttatc 1907341 cagtttatta accgctaaaa caacaggctt ttttgtgcgg tacaaaattt tcgccacttc 1907401 ttcatcagca gctgtcacgc cttcacggcc gttcaccata aaaataatca cgtccgcttc 1907461 atccatggcg atttcagctt gctggcgaat ctgcgctaaa aacggctcat caccgatatc 1907521 aataccgccc gtatcaatca aattaaaatc ataattcagc cattcagccg agctgtatat 1907581 ccgatccctt gtcacgccag gggtatcttc tactattgaa attctttctc ccgcaatccg 1907641 gttaaagatt gtggattttc ctacatttgg tctcccgaca atggctacga caggtttacc 1907701 catagtaccc ttcctttcaa tccagccgct ttcattttta cataaatttt caaccggtta 1907761 ttaaaatcat ttcattcact tttatgaaaa gaaacccttc agaggaaggg cttaactcat 1907821 ttattatatc agtttttact gggatcacaa ctattcttaa aaatgtttca cgatcaaata 1907881 cacgtcatct ccgattctgt gagctattcc atcaaggatc gcctcaagat ttttagcgaa 1907941 aagctccatc tccttttggt cattgcaaaa aaagacaggt gctccccctg caacccgatt 1908001 tcgatttgtc gtgattacag acaaaatcac tttcgtaaga gattcactca tcctatcacc 1908061 ttatcctgat tcttgataaa ttcagtcggc attctaatcg cattttccag ggttggaaca 1908121 ttgctaataa tttgaacagc cgtttcggga tggtgaattt gcgggagaac aaatactgcc 1908181 actctcccat catttaaatc ccgttttgca attggtgtca aagatggctc tcctgaatcc 1908241 cgataaaccc cgagcacatt ggaaacatca aataaaatgg cctgacgctg ccctaaattt 1908301 gctatcgtcg ctgctgaatt aaagtttttc ggcgtcaaaa taaagcccat gccatgcttt 1908361 aaaatcagtt cctgtttctc tggaagcccg atattcatca tataaatatt atcaacaaac 1908421 agtcccggac cgtcaaagcg cggctttatg tactcgatat ctacaatatc cttcaacaca 1908481 ctgcccgaca taaacttcat ggccagtaaa aaacaaacga cagccgctat gactgcagcc 1908541 cagatggata aaaacacata cgcagaggtt gtcaaaagcg ctgtaaagat cacaatataa 1908601 tttctgcttt caaacgcaat ggcaatcccc tcaatatatg tgcttcccct tgagacaagt 1908661 tcatacgaat ccatttgcgt caatgtgttc cgctccatgt ttcggacatc tctaaattgc 1908721 gtcgctgcca atgttaaaaa tgtgatggcc gtaaattcct cctgcaaaag cgccggcata 1908781 ataattgcac ctaaaccagc cgctatcaac cccagtgcga tgtgaatcac tttcccatga 1908841 acataggtcg gatactggcg gtaatccgtt ttcagcatat aaagccttgt cgcaattccg 1908901 gcaatgaccc cagcaataat cggatagatg taatcactca tgacattttg gtagctcctt 1908961 tgtttgatct tttgcttttc tgaccaatct ggcttgcgag gtgttcgtat ttagatatgc 1909021 caaacagcaa tatcatcccc gcagaacacg cattcagcca ttgaaagccg ccgacagcca 1909081 tagccccggc caacttctgg atcacaaatg aatacaccag ttcgccttgg cacatcccta 1909141 ggacaaataa gacaagctgc ttctcaaaat tcctttcaac agaagctgtt aaaagcacta 1909201 ttaatataac agcagcccac tcaggtttta tgatgaacca aaccgggtca tataatgcaa 1909261 aaagataaac aaacgcatac gcggcaacaa gcgtcagata gaccatgatg taacgaaaac 1909321 gatacattcc caaatacccg gcatagacac atccgcaaac gaaaaacatc aaatatgcag 1909381 cattcaggga aaaatataaa gcgatgtcat gtatgcttag aataatatta gttaaaataa 1909441 agacagagac ggcaattcgt cttttcgtct tttcaaaaat aaatgttgtc agaacccaca 1909501 gaaaccacat tgaccaatag taataaaatt gttccatttt acttcctcca tattcccagt 1909561 atggagttca agcacatttt ttaaacaatc gatctcacat taaggagtat gatcatggga 1909621 aaagacagac aagagaaaaa actcaaagct tcaggcagag tcgaatcaga tcgcgaccag 1909681 tccattcact atgacggagc gacaagcctt gaacaaaacg gaagattcaa aaagcgaaaa 1909741 tcataataca aaaagcccaa accacatatg gttttgggct tttatcattt atcgcacact 1909801 atagcttgat gtattgaccc ctctctctgt gagccaatga tgggtttcac ctttgatcac 1909861 aaggggcgcc ttttgtaaat cggcaattgt tctggcaccc agcacggtca taatcaactt 1909921 taattcctca aggatcagct gaatctcctc aagcagtcct tcctcaccgc tgtcagtcag 1909981 cgcttttaaa aaatgccctg ccattccggt gcaagaggcc cccagcgcaa ttgcctttgc 1910041 cacgtcaagc gcatcttgca gaccgccaga ggcgatcatg gtgcttgcag gaaactcaga 1910101 gcggatttcc gccaaacttg cagctgtcga aatgccccac gaattaaaaa aggagatttg 1910161 ccgctgtctt cggagatttt cgattttcga gaaatttgtt cccccgtaac cgccaatgtc 1910221 aacagctgca gcaccagctt catacagctt tcctgctgat gctttgctca taccgaagcc 1910281 gacttctttc acaatgaccg gtacactgac ccggctgcaa atttgttcaa tgcgtttcaa 1910341 tgcgccgcta aagcttctgt ccccttcagg catcacaatt tcctgaatca cattgaggtg 1910401 gatctgcagt gcgtttgctc caatcatctc aacggcttcc tttgcctgag cagccgttgc 1910461 ctcgcttccc aggttggcaa aaatcagccc gtttgggttt tcctttcgaa caatttcata 1910521 ggaaagacgc tctgatggat cttttaatgc tgacatttgc gatcccacag caaggggaat 1910581 tccagcctga gaagccgctc gcgcaagcga tttattaatc tcatatgtaa gttttccgcc 1910641 gccgccagtc attgcattga taaaaatcgg cgaactgctt gaaagttcgc cgatttttgt 1910701 ggaaatatct acttgttcta atgcaagatc gggcagactg acgtgaacaa acgtaatatc 1910761 atcaagacct gtttcccgct tctggccgat ggacaaggca tgattgatgt gttgtctttt 1910821 tcgttctgct cgagtcacgt ttatcaccaa ttattttagt ttattcagct tatctccgat 1910881 cagatctcca agctggaagc cagtgcttgt ttcttccttc gcttgatatt gacggtaatc 1910941 ttcctggtca gctttaggcg tttcttcaag ttcacgcatg cttaatgaaa tgcgctcctc 1911001 attttcattc acatcaagaa ccttcacttt tacagtctgt ccttcttcaa ggacttcatg 1911061 cggcgtgccg atgtgtttat tggaaatttg agaaatatga acgagacctt caacacctgg 1911121 aaggatttca acaaaggcac cgaagcttac aagacgctgt acagttcctt caagcacatc 1911181 gccaggcttc actttttcgc cgatttggtt ccaaggtcca ggcagtgtat ctttgatcga 1911241 taaagaaata cgttcattat cacggtcaac cgataacact ttcactttta cttcttgtcc 1911301 ctcttcaaca acgtcagacg gcttctctac atgagagtgg gaaagctgtg aaatgtgtac 1911361 aagtccgtcg atgccgccaa tatcaacaaa cgcgccaaag tcagtcaggc gctgtacttt 1911421 gccatcaagt acacttccaa cttcaagaga ctgaagaagt tcttgttttt tattcgcttg 1911481 ttcactttca acaacagcac ggtgtgaaag gatcacgcgg tttttatcac ggtcaagctc 1911541 tacaacgagc agtgacagtg tttttccttt atagtcagtg aagtcttcaa cgaaatgtgc 1911601 ttcaacaagt gatgccggaa taaaaccgcg aacgccgata tcaacgacaa ggccgccttt 1911661 cacgacatct ttcacttcag cttcaaacac ttcttttgtt tcaaattttt tctcaaggtc 1911721 ttcccaagcg cggtctgcat caacagcacg tttagataaa atcaaagcat cgtcttccac 1911781 ttttgttact ttcaggtcaa gctcgtcgtc tactttaaca acatccgatg ctttctctac 1911841 atgaagactt gataattcac tgattggaat aataccggat tgtttgacat tgataatttc 1911901 tacatctaca tgtttgtctt ctacctttgt cacaatccct ttaactacat ctccaacctc 1911961 tggcacttga acatcaattt gattcatttc ctctgtcatt tgaataacct ccttggtcca 1912021 aacctacaca gcttaattaa aacggtttga aagctgaaca tataacatgc ccgcttttag 1912081 ccgaatatgt attaaagaat catccaaaaa agttttttga atgatcaata aaaagtttta 1912141 ttagtattaa cttctaataa aaggacaggt ttgtcaagca ataacattct atcttcgttg 1912201 aaaaattcaa aaaaagtggc atttgccatc ctcagcggga cttttgctcc acagcctcga 1912261 ggattttatc agctacctct tgaatggaaa gcgatgtcgt gtcgatttca agagcgtctt 1912321 ctgctttacg cagcggagat acttcgcgct ctgaatcaag cttgtctctt cttgcaattt 1912381 cctcaattaa tgtttcgtag ttgacatcaa agcctttttt cacattttct tcataacggc 1912441 gtttcgctct ctcttccaca gatgccaaaa gaaagatttt tacttctgca tttggcagca 1912501 catgcgtccc gatgtcacga ccatccatga cgacgccgcc tttttcccca agctgctgct 1912561 ggcgtttcac catttcttct ctgacacttc tgtgcttggc cgcaattgaa acttggttgc 1912621 tgatttcatc tgttctgatc gcctcagtta catcggtgcc gtttacaaac actttttgtc 1912681 catcttttgt tgtaatcagc tcaatgtctg tccgctttag cagctcagcc agtttttctt 1912741 catctgtcag atcaacgttt tcctgtaaag ccgcgtacgt aatcgcccga tacatcgctc 1912801 ctgtatcaat atatatgtac gattttttct cagccacaat tttggcaacg gtgcttttcc 1912861 ccgcagctgc cgggccgtcg attgcaatcg ataatttctt ttccataatt cctctccttg 1912921 ctcttttctc ctctaaggat tgtatcacga actttatgaa aaagggtgaa aaattgatga 1912981 ataattaatg tttgaaggtt tcaatcctat tgttttcctc cattttatcc accccttcat 1913041 attgaatcac ttttgatacg tatggttcaa tatgctgata gtgaaaaaga aattggacac 1913101 caagtaaaat gatggcctga atgaacaata atttgatcag cagccgttca aatgttttca 1913161 ttggagcacc tccattacaa atagtatgga agtgtttgcc gatgtttatt ccattcgggc 1913221 ctttcttctc ttatttaact ggcgcctgat gcagtattga agcaaagcct gctggtcacc 1913281 tgctgcaatt tctgaatact ctaaagtcat ttttcgtttt tctgacttgg ggtcattaaa 1913341 gattcgtctg acaactgctt ctgtttctat ttgacgtgtg tgctcctctt caggaagacg 1913401 gatgatcagg cgcaatgatt cccccgattg aaaagaaagg ccatcagcta aaaccacggc 1913461 gatgccgcct gcactgatgt tataggatag tgtgcggatc tcttcttcat ttcccggctg 1913521 aatttgcaca tctaataccg catcagttct tacatattgg cggcgctgga ttcttttcat 1913581 tttttcacgg ggaggcattt caagacagat catttgaagt ttgtccttca ctttaccttt 1913641 tatacggctt ataaagcgat aaggaacttc gtcttttccc acaaactcta ccgttacttc 1913701 catatcgtta tgtaaaatca cagttcgccc tgtaactaca tcaacaggat acgcgatcaa 1913761 aagttcattg ttttcgatgc tgaccgcctt gctttttgcc tttttcaatt cattttcttc 1913821 tatatattct aaaagtacat tttctccaat ctctatcatt gacttcactc tttcgcattc 1913881 aatatactca cgtttttatt aaagcacgta atgaaaaaaa ggaaaagaca tttagtcctt 1913941 tcctcctgtt tttataggtc tttatatata ggttctgcat tttttagttt ttcaaccttt 1914001 tcttccgatc cgtctttggc attgatatac attctgaatg tgtcattttc aattgtccca 1914061 agcatttcgt agcataacac ttcttgacct agttcatttg taatcaaagc gagccttgtt 1914121 tctctcactt gtacattttt atttaattta gactttgcct ctgcttcagt aattgcaggc 1914181 ttaggtatgg ttctttttct gtgagatgtg aggaagtctc ttgctgaaaa gccgacaacc 1914241 tcaccgtcat ccaaggccac tttcatacga attgcctcgg ggtacatccg gactttattt 1914301 tcaacaggaa catatgaaaa tacaccgatt ttatcatatt gggcactttc atcaatttcc 1914361 aaatcatctg tttcaaatcc gtttttcttt aaaaatgcaa gcgctcggtt cgatccgtca 1914421 tttaaactga ttttctgatc tttcacttct ctgttttgga tcaagtatac cggatgcccg 1914481 cccttcttcg taatatccat ataaatcact gctttatggt ctgggtcttt catgctgatg 1914541 ctatatacat cgcgatttgt tttttttccg ctctttacca ctttaattga ataattgtca 1914601 tctggggcaa agcgctcagc aatttgtttt gcttcctgtt cggaaatttg ttttcccttc 1914661 agatggctga agcctttctc ttcttttttc gtactggtga aactcgggcc aagatcagtg 1914721 ccagtggaga atgcaccaac atttttttcg actgttttaa agctgttgat aatcgtatta 1914781 tcactttgtt tttcgtcaga agccagagcc atttctacgt ccatccagcg aaggtttttg 1914841 ctcatgacaa ggtgctgaac atgacgcaat tcattttgta tatcttcgga ctgctgatat 1914901 agcttattta gtgatgtata ctcgttttta tcaagcggct tttggtccaa atctctgact 1914961 gacgttttat agctgaaatc gccgatcttt gataatagct cttcagtttt attaaacggc 1915021 attaatgtaa gcggcagctg actgacgctg ttatgagctt ctgatgtaat cctccacaca 1915081 tcgatcaatg caggcgacag tgatttttgg ctgttcatgg caagtgttgt tccgatttta 1915141 tcatgaagct gatccacctg ataggtaagc tcatgaaacg cccgctgata gttattttca 1915201 gcatgaagaa gaactgcgtc tttttcctgg tgttctttgt atccccagta gcctgtaccg 1915261 actattgcaa taccaagcac ggcgattaaa attcctctga tcatttatca cacctctttt 1915321 tatgctttct catatctgct actcacagaa aatgtgttta ccgattcttt taatctgcgg 1915381 acgcccccaa atccacggac ttgtagccgt atccggatta aagtagtaaa gtgcttcctc 1915441 tgatgggtcc cagccattga tggcatccag cactgcttct cgtgccgttt cattcggctg 1915501 catgtaaatt tgtccgtcgg ctactgctgt gaaggcaagc ggctcaaaaa taacccccgc 1915561 tactgaattt ggaaataacg ggctgttcaa acggtttaaa atgactgctg caatagcaac 1915621 ctgcccctcg tacggctcgc cccgggcttc gccataaacc gcttgagcaa gcagcctgat 1915681 atcgttgttg gaaaatccac caggcatgtt cgctgctacc gcatcctgtt ttcttgcttt 1915741 tgctggtgta ttgttttgct gtttattcgc attcgcttta ggcttctgcg ttgttttttc 1915801 cgcaggctgt ttctgccgtg cttctgcttg ttgtcttgcc ttttgtgttg ctgcttttga 1915861 tggtttcgtc tgatacttta gcggaatttt tccgtaatgc gtgaatgtat tccctttatt 1915921 gagctgttcc atgacatatt cacgatagta ttttgattta catattaagg tttgctttgt 1915981 tttagctcct acaaggccgt caacctcttt taacccgaat tgatcctgaa aatttcgaac 1916041 tgcccagtac gtcccccatc cataaacccc gtcaattttt ccgttataat atccgttgta 1916101 ttgaagacgc gcctgaagct cgaccacatc atcccctgtt gcccctcttt gaatgacctg 1916161 attcgaaaag gcagagatcg tttcagtatt aataaacgtc gttattgtaa aggaaaaaag 1916221 gatgagacat gccataatcg atcctttgga cttcatcttt tcaagcctcc tactgcaaat 1916281 ttttaagtgt aatcgtattt tctgtaacga ggttattttt atacactctt tccttgttat 1916341 ccctcagaac ataaaaactg cacacaaaaa agccgcacgg ttgctgtgcg gcttctatac 1916401 ttgcatcata ttaacggaac gggctttttt cgctttacgc aaaccaaacc accataaaaa 1916461 taccataaat ggaagcatat aataaatcca attgctaagc gctgttagga taaaatcata 1916521 tgatccatgc aaaagggatg ggacaactaa agaaagagta agccacttta cacgcgcctt 1916581 atcagcggaa aaacgggctt ttccaaggta aaatcccatt ataacgccaa tcaaggcatg 1916641 gcatgaaaca ggcagcagcg ccctgacaaa cgcatgctcc acgccgtggc caattaaata 1916701 aagaatattt tcgagggttg caaaaccgag tgatacactt gcaccgtaca caatcccgtc 1916761 ataatgctca tcaaagtggg cgtgcgggta aacactgatc atcagtataa accattttaa 1916821 tgattcctcc aaaaaccccg aagataaaaa agaaacgaaa aagcttccgc ctcctacatt 1916881 ctctttttca agtacatact ggataaacat gatgggaaat acaagaacaa ccccgagaaa 1916941 aaacgaccgt agcaccatat gtacaggttc attatcatac tgatctttta aataaaaata 1917001 acttaataac gcgatgccgg gggcaattcc tgcagagatg attgcaaaca tcaggcaacc 1917061 tctttccttt atattcctac atctatccta ccatgttgtt taaaatttta catctgtctg 1917121 cacttaaaaa aacaaaaaga gcatacgaat gcatcatatg ctcctcatct ttaatggttt 1917181 tctcttttgg cgatttccgc tgcgatatgc cccccgtgaa acctgccgtt ttcaataaat 1917241 atttcatttg cattgtttcc cgcagcaata acaccggcaa taaagacacc ttcaacgttc 1917301 gtttccatcg tttcttcgtt gaaaaatgga cgccctgttt ctttatcaat ttcaacacca 1917361 attttttcaa gaaattgatg atcgggatga tagcctgtca tggcaaatac aaaatcattt 1917421 ttaatggtaa tgagttcttt ctctccggag cgaaacacaa cttcattctc ggtgattttt 1917481 tcgacacaag ctccaaattc catacggatt gtaccgtttc tgacgagagc ttcaaattcc 1917541 ggcagaatcc acggcttaat gctcggagaa tactcattgc ccctatataa aactgtgaca 1917601 cgcgccccag atttcacgag ttcaagggcg gcgtccacgc ttgaattttt cccgccgatg 1917661 acaacaacat ctttatcaaa atacgggtgg ccttctttaa aataatgaaa tactttcggc 1917721 aaatcctcac cgggtacgcc catatagttt ggatgatcat aatagcctgt ggcgatgata 1917781 caatatggcg tcgtgtaggt ctcttttgac gtctcaataa cgaatgtgtt attttgcgtt 1917841 ttcgtcactt tacgcaccat ttcaaacgca ttaacacgga tgtttttccg tttaacgact 1917901 tcccggtaat acgataaagc ctgaattctg acaggcttcc tgttctctgt aataaatgcc 1917961 acatctccga tttcgagctt ttcacttgaa ctgaaaaagg tttgatgcgt cgggtaattg 1918021 taaatactgt taacgacatt gcctttttcg atgacgaggg catcaatgcc aatttgtttt 1918081 aggtgaatgg cagcagatag tccacaaggt cctccgccta taataattgc tttttcttga 1918141 atcatttctg tcaactcctg cgattggcat ttcacttcat attttctatt tccgaataaa 1918201 aaaatctcct attttatcat aggagatttt ttatttttat gcaaatcatc aacttatatc 1918261 cagcctctaa aacgcgaagc ttcagccatt ttgcgaacgc cgaccatata tgcagcgagc 1918321 ctcatgtcaa ttcttcggtt gttagccatt tcgtaaatat tgttaaatga tttgaccatc 1918381 attttttcta atttttcttc tacctcttct tcactccagt agaagccttg gttattctga 1918441 acccattcaa aataagaaac tgttacgcca ccggcacttg ccagcacgtc tggtacaagc 1918501 agaatgtccc ggtctgaaag aatttttgtt ccttcaagcg ttgttggtcc gttcgctgct 1918561 tcaacgacaa ttttagcccg gatattatgg gcattttctt ctgtaatttg attttcaatc 1918621 gcagcaggaa cgagaatatc acaatccagc tccagcagct cttggttggt aatggtatcg 1918681 ttgaaaagct ttgttacggt accgaagctg tcgcgtcggt cgagtaaata atcgatatca 1918741 aggccttccg gatcataaag tccgccatac gcatctgaga tgccgacaac ttttgccccc 1918801 gcatcatgca taaattttgc caaatagctt cccgcgtttc cgaagccttg gacaacgaca 1918861 cgcgcacctt taatatcgat gcctctcttc ttagccgctt ctttaataca gatggtaaca 1918921 ccttttgctg tcgcagattc tctcccgtga gatccgccaa gcacaagcgg tttgcctgta 1918981 ataaatccag gcgaattaaa ttcatcaatt cttgaatact catccatcat ccaagccatg 1919041 atttgtgagt ttgtaaatac atccggtgcc ggcacgtctt ttgtcgggcc gacaatttgg 1919101 ctgatcgctc tgacataccc tctgctcaga cgctccagct ctctaaacga catatccctt 1919161 ggatcacaaa caattccgcc tttaccaccg ccatatggaa gatcaattat gccgcatttt 1919221 aaactcatcc aaattgaaag cgccttcacc gccttcacct ctttttctgt tacgttcggg 1919281 tgaaaacgta tcccgccttt cgttggaccg acagagtcat tgtgctgcgc acgatatcct 1919341 gtgaaaatct ttactgaacc gtcgtccata cgaacaggta tttttaccgt taataatctc 1919401 atcggctctt ttaacaattc gtatacctct tcgggatatc ccaatttttc cagagcctta 1919461 tgtattacgg tttgggttga ttttaataca tcaagtttgt cctcttctgt atgaccggtg 1919521 tttcgatcgg ctgccatttg agttaacctc ctagaatctt ctgtttctca catgctccct 1919581 ttcagagaat agtatacacc ttcatatgat ctgtgcatag aataaacgtt atgtttttcc 1919641 atgtttttta acgaaaaaaa actgctgaaa tcagcagttt tccgttgcat tcttatgaaa 1919701 aatgagtttg tatcgtttct acggcattac cgtccataat gagcttacca tactcttgca 1919761 ggcgataaat cgttaaagtt gtcggattgc cgtattcagc cagaaccgcc acaacccctt 1919821 cagccgtatg tgaccctaga tcttcaaggc ttaaaaagta ctgcccgtca tagtggtaga 1919881 cagttccccc tgtgataccg attcgctgta agctttctga aagctgaatg atatcttcaa 1919941 aggaatggaa ttgatatatg atgtccgcgc tttcatcaag cttgacttgc atttcgatgt 1920001 aatcatcatc atactcatcg tcttctgaat cggcgtcttg gttctttgtt acaatcacga 1920061 ccatcccttg tgcttggaga gaatacactt ccactgcaat cggtccattc gcttcaaagc 1920121 cgagctctgt atttgcttca ttcatcatat ctttaaataa ctggtggact ttaaatgagt 1920181 ccttccagag gtcttctttt gtcaatcccc ggtctgtcaa atcatcgagg gttaaaaaga 1920241 ttttgatctt attataattc agacgctcaa gccgcataac gttccctcct gcctctactt 1920301 gcacacaaat catataacac attatatgag atgatgagtc ataggttctt aattgttatc 1920361 agtttacact gagttcacta gtaagacaag cacaatgcag tttttattgc catacggatt 1920421 tttgcttttt agaagttatt ctggcccgca aagagtcaca atgtgagttt caggctcagc 1920481 acctaaacga agaggcactt ttgtcgtgcc gtagccgttg ctgatcagat atgccgcgtt 1920541 tttaacaata cctgttttcc ccagttcata aggaccgaat tttccaaacc tgatctggcc 1920601 tccatgggta tgtccgctga gtatcacatc aataccgtca tcttcattga tttgttcatg 1920661 aatctccgga ttatggcaaa ccagaatatt cagctggctt tcatcaagtt ctttgatggc 1920721 ttcctcataa tgatccatct ccatcctgat atcatcaacc cccgcaatcg caatcgtatg 1920781 cccattgtat gaaaacggga ctgactcatt tctcagagtg atgacgccgt gcgctttaaa 1920841 tatggaatac agcttatgct gcctgacttc ataatcatta ttcccccaca caaacacgat 1920901 agggaccccg aaatgtacga gccttttgat gttttcctcg attctcgcac tgggcacccc 1920961 gccctcagct aaatcaccgc cgattataac caagtggggg gcatggcttc gcgctttttc 1921021 taaaaggtct tgatcgatga gacgtttgtg aatgtctgaa ataaaaaaga ttgtcagagg 1921081 cggcttgccc ttcatctttg ataaaggaaa cgtatgtgtc ttcaaatgat tgccttttgc 1921141 tgttgcatac atttttgccg tcattgccgc tgccgcaaca gttagtacac cggcaatttt 1921201 cactgatagc ttcataaaaa actctccatt ctttttagaa cttatcaata agacggacaa 1921261 taaaaaaaga cgtttctatc gtttgagaaa acgccccatt ttatttactt tcaaaatata 1921321 gattaatgtc atatttgtgc ttcatcatat gaaaaacaga ctctctcgcc ttccatttat 1921381 cgggctgcgg ccagagatca gtgcttttct gaataatttc acatctcagt ttatggaaat 1921441 cagtctcgga tttttcttcc tttttcttga aataatatga agtgcagtag gcaaaagcgg 1921501 ttgccagcat ccaaaataaa taaaaggtat ggctaagtat ttcttgaagt ataagctgag 1921561 gctccgggct tttgatcatg atcataacac ataataagcc taggcagata agtgaagccc 1921621 atcgccatct gcggcattgt gctgcataat tttcgaattt ttgttttcgt tttaccagcg 1921681 cttggagcat ctgtttggtc ggcgcgtctg taaactgatc cagctgattc cataaggatt 1921741 ccatacgctt cacaccttgt ccattttcat tgctacaata tatgaacgta aaataaaaat 1921801 aataccctat tcatccatta aagggatgtc caaaacttgt ccggtgtaaa catcatttcc 1921861 attcagatga ttatatgctc gaattttttc ttctcctgtc cggcttttat aatacttcat 1921921 ggaaatgcgg tatagcgttt ctttcttttg gacggtgtgc ttgacaacgc gattcggcac 1921981 attttgaact ggctcagctg gctgttcttg ctgttgtact gttgattggg aagaggaagc 1922041 agccgcggcg gttgcttcct ccttatttgg cgagtcttct ttttccgcta cagcagtctg 1922101 tttcttatca gcagctgttt gctcttttgg cttggaatct tctggctctt tttttgactc 1922161 cttctgcagt gcggtttctt tagtgtctgc ggtatcgttt ttatcctctg atttcgggac 1922221 aacctcatat ttgctttggc tgctgtcaat aaaaacatct tcataatcgt catgattatc 1922281 cgggtggctc tttagataaa ataaggtgac taaaacgata accggcacaa atacaaatat 1922341 tactgcgagt actgtgaata atggcgtttt tgttttgcct tgcttttttt tctgttctct 1922401 ttgatttttt acagattgtc ttgtcggaag gctttctcca tcatcgacat aatcgtccgc 1922461 caatgcggcg ttttgatctt cataaagatt ctgggctttt cttctctcta ctctcgacat 1922521 gttcgtcatg tttatccctc ctcacatgtt caaaacgaat ctgacaggca aacacggcat 1922581 caatgataaa atgcgccgtc atcggaacaa ataagttgcc ggtccattca tacatcagac 1922641 cgagcaaaaa gctgattgct gtcaccataa taaataacag ccattttgac aaataccgaa 1922701 agtgcagagc ggcaaatata aggctggccg tccataaacc gatatgagtc tgcagcactc 1922761 ctctgaataa catttcttcc gcgaaagcaa tcagaagcgt taaaaatata atatgaggga 1922821 ttgacctctt actgaatatt tttttattga ttccgccgtc atcatataaa tgagacggaa 1922881 accatttcat tactgccata tcggctaaaa taacaataac agctatagaa acaccatacc 1922941 agatgattcg catatcgcga atgtcccaga gctttaatac gtcccgtaca tcctcaaaaa 1923001 agaacagtcc tgctgcagca gcggcaaaga tgatgagtag ctgcgtcaaa tataactgct 1923061 tcagcatatc atggtcagtc atatgctgaa tataatcttt ttgctgtttc agttcagctc 1923121 acctacagtc tgcaagctga atatccggtg caattccgaa ctccagctgt ctaatggcgc 1923181 cattttactc cgttcccctt tttgttcata caaggataaa tcaaaaccgc aatgtgaaca 1923241 gcacgggagg tttccgtcat caggctcgta tgattcatca aagtaggtta acagtgcctg 1923301 ccttaaacag ccgtcacgct gaagcaaaaa tgatacacgg tgcatttttt ccagcttcag 1923361 ctccatgcga tatgaaattt ctttcttcat cagttcaact gatgtttttc cctgcataaa 1923421 gagatgaatc atcatacggg cctgtgtctc tccgacgcca tactgaagta atacgtcacg 1923481 cagccttctc tcatcccgct cctccgtctt ctctagcaca cggattacgt cggcgatttc 1923541 ttcagctgtg acactctcca tctggataat ttgttcctgc aattcaaaat cccctggcgc 1923601 ccgcagcaaa atgctgacac tcggctttcc gtcgcgtccc gctctgccga tttcctgcat 1923661 aaaagcttct gccgtctgcg ggagatgaaa atgaatcaca tatctgatat caggtttatc 1923721 gacacccatt ccaaacgcat tcgtacaaca tatcacatca agctggttat gaataaactg 1923781 ctgctgaatt aaaatcctgt cccctgactc caaaccgcca tggtaaaagt cggctctgct 1923841 gctcgttttg cttttaattt cacccgctaa ttccttagcc catttccgtg ttggacaata 1923901 aacaattccc ggaccttgca ggttttcaac cagctgaatg accctatcta ttttttcggc 1923961 agtatccgcc gcattttcaa ccctcagtgc gatgtttggg cggttgactg agttgagatg 1924021 gcgtacagca tgctgcagct ccagcaggtt catgacatct tgcagcgttt cctttgtagc 1924081 cgtggcggtc aatgccagaa cgggtgggtg tccaagtttt tttctcagct gtccgagctt 1924141 tgaataatca ggcctgaagt cgtgtcccca ttcagaaata caatgcgctt cgtcaataac 1924201 aaataggcta atcggaacgc ttttcaattt ttccaataca tatggagact gtaaagcttc 1924261 aggagacaag tacaaaaatt tatatcgatg aatatgttct aaaacaaatt gtctttcctg 1924321 cctgttaagc atgctgttca aagctgcagc acgcttttcc ccccgggctt tgagctgctg 1924381 cacctgatcc tccattaaag aaagcagtgg agaaacgatt aataccatgc catcaagcat 1924441 ataaccaggc agctggtagc aaagcgattt ccctccccca gtcgggagca ttgcaatggt 1924501 atccttcccg ctgagtatgc tttcaataat gtcctgctgc ccttttttaa aggaagtaaa 1924561 accaaaaaac tgatataacg tttgctgtaa tttagtcata ttgctgcacc tgctttgtca 1924621 atgccagtct gatttgaaag tagctgaacc gctgttccag cccgtcgcga atttgtttga 1924681 ttttattcgt ccgcatccgt ttggcaaact ctgcgatttg aagctggtct tctgctgata 1924741 catagtcatt aatcataaac gcaggctcat ggagagaaat ctcgacaatg tggtcttcaa 1924801 tcgtcgctgt tttcagcttt ctgatttcag caattcgctg tatcggaaac ccttgtttga 1924861 ccatctgcca tgttttcctc gtcgactctg tcagggcatt atctaagtgc acatcagaaa 1924921 ggagatcctt taacaaagca tcttcacact ccggaagaga atgaataaaa taatgtaccg 1924981 aagcccaaaa catgatatag acataccatt cgtcttcttt cagcgtatca gcaagctgcc 1925041 tgctcgtata accgatccga tggtgcgagg ttaaggagta gacaaaaatt tgcgctgctt 1925101 tgttttcaat ctttttcaaa tgcgcctcaa gcatggcaaa aaggcttttt gccatctcta 1925161 tatgatccgt atgccgggac aggtatttct ttacccagtg aagtgtctta tgatcctttg 1925221 tgacagggat atactgcctg ctcccttgct gtttatggga taggacctgc acaagcagcg 1925281 aaagcctttt ccaaagcacg ccggcagcct gctgataatg agcgccgtga caatgaacgg 1925341 gccaaggccg ctcgctaagg gcatgtctca aaactgctgc gccgctggct gtcactttgt 1925401 atgtatctga ttcagacatt ggcgcgagat atgaatgctt ttcaagcttg tcaagcgacg 1925461 cagaaatatc gcttctcgaa cattttgccg ccattccaaa gtattttgca gtctgaaata 1925521 agccggcatc ttgaatggtc tgtgacgatc tcttgccttt gaataggtga aaaacagcgc 1925581 ttcccgaccg ttccccgttt attttgcaaa gacaatcgag aaccataata tcgaagtaat 1925641 ttaatgacaa cctatccacc tacattcttc ctgacaaaaa tcgttgattt gctcttttta 1925701 ttttaacaga tttcaaacag aaatcgacgt ttaaagtcat cattaagggg gatgttatgt 1925761 agataacccc ttatgtgata agcattctca atcatttttc tgttgaaatg tggcagcaac 1925821 atcattacaa taagtaagag gaataggtgt taaattgatt aaatataaag attgatccat 1925881 ttgttccacc aagaacaatc tgggaggttt tattcatggc aaagtacaca atcgtagaca 1925941 aagatacatg tattgcatgc ggcgcttgcg gagctgctgc accagacatt tacgattacg 1926001 atgatgaagg catcgcgttc gtaacgcttg atgaaaacaa aggtgttgtc gaagttcctg 1926061 aggtactgga agaagatatg attgacgcat ttgaaggatg ccctactgat tccatcaaag 1926121 tggcggatga gccatttgaa ggcgacccgc ttaaatttga atagaagtaa ctaaaaaaag 1926181 ctcccgaacg ggagcttttt tatttaatgg atatgtgcac ttcgctgctg ctcaatccat 1926241 ggcttaagct tgataaaaat tagtgagaat acaaccgtaa ttacaatacc ttttatcatg 1926301 ttaaacggca ggatacctgc gacgactgct gtttttagcg cgctgtcgga taatgccggt 1926361 gaatgtaaaa accacgtgta tgccggaaga atcagaacat aatttaaaat actcattaaa 1926421 atggtcatcg ctgcagttcc caaaagcagg ctgacagcca agccctttgc tgagttgagt 1926481 tttttaaata agaaagcagt cggtaatata aagagtgttc ctgcaataaa attcgcaact 1926541 tgccctacag gaactccggc catgcttccc tgaatgatat actgaagaac attttttatc 1926601 gcttctacgg caatacccgc caaaggtccg taaatcagaa tggcaataat tgcgggaacg 1926661 tcgctaaaat cgatttttaa ataatccgga agacccggaa acgggaaatt taacagcatc 1926721 aaaacaaatg caatgctgct cagcatgctg accacaacta atttttttac tttcacttca 1926781 ttctctcctt ttcgatcaca tcttactcga aaacggaaag gttcttttcc agccaataaa 1926841 aaaaccgctt catatataaa agcggggttt cgaaaattag gctaggcaaa gaaacgtttg 1926901 aaaaattcaa tttcaaaacg cttatgaacc tccatcttct cccatccaga ctgtactgtc 1926961 ggctccggaa tctcaccgaa tcctgctgta aagacagctc gcgggcttag agccattggc 1927021 tcatcaccgc cggtagggaa tttcaccctg ccccgaagat tgatcatatg aaatttaatt 1927081 acattataaa cgataactgg ttggctgtat agagaattgc ttcaaattaa atatattacc 1927141 tgcaagctgt cagatcattg atttattagg ctttactttt atcctttact gcgtcaatac 1927201 acgttgacac tcttttgaga atatgttaaa ttatcagata tttagtttgt caatttagga 1927261 ggaaatctaa cgatgtttcg agtattggtc tcagacaaaa tgagcaacga cggtttacag 1927321 ccacttattg aatcagactt tattgaaatc gttcaaaaaa acgtagcaga tgcagaagat 1927381 gaattacata cttttgatgc tcttttggtg cgaagcgcga caaaagtaac agaagacctt 1927441 ttcaacaaaa tgacttcttt aaaaattgtc ggaagagccg gtgtcggtgt cgataatatc 1927501 gatattgatg aggctacgaa acacggggta atcgtgatca atgctccgaa cggcaacacc 1927561 atttcgacag ctgagcatac atttgcaatg atctcttctt taatgagaca cattccgcag 1927621 gctaatatct cagtgaaatc cagagagtgg aaccgcacag cttatgtcgg ttcagagctt 1927681 tatggaaaaa cgcttggtat tgtaggatta ggccgaatcg gaagtgaaat tgcacagcgt 1927741 gcgagagcgt tcggtatgac tgtgcacgtt tttgatcctt tcttaacgga agaaagagcg 1927801 aaaaaaatcg gcgtaaacag ccgtacattt gaagaagtgc ttgaaagtgc ggatatcatt 1927861 accgttcaca cgcctttaac aaaagaaaca aaaggcttat tgaataaaga aacgattgca 1927921 aaaacgaaaa aaggcgttcg cttaattaac tgtgcgcgag gcggaattat cgatgaagca 1927981 gcacttctcg aagctttgga aaacgggcat gttgcgggag cagcgcttga cgttttcgaa 1928041 gtcgaaccgc cagttgacaa caaacttgtt gatcatccat tagtcattgc cactcctcac 1928101 ttgggagcat caacgaaaga agcacagctc aatgtcgccg cccaagtgtc agaagaagtt 1928161 ctgcagttcg caaaaggcct gcctgtcatg tcagctatca acctgcctgc catgacaaaa 1928221 gatgaatttg ctaaaattaa gccttaccat caaattgcag gaaaaattgg cagccttgta 1928281 tcacagtgca tgaaagaacc agtacaggat gttgccattc aatatgaagg cacaattgct 1928341 aaacttgaaa catcgttcat tacaaaagcc cttctgtcag gctttttaaa accgcgcgta 1928401 gactctactg ttaatgaggt caatgccggg ggtgtcgcaa aagaacgcgg cattagcttc 1928461 agtgaaaaaa tttcctcttc tgaatctgga tacgataact gcatcagcgt aaaagtgaca 1928521 ggagaccgca gcacctttac tgtaacggct acgtatattc ctcatttcgg agaacgaatt 1928581 gtcgagatca atggatttaa tattgatttt tatccgactg gtcacttggt gtatatccag 1928641 catcaagata caacaggtgt catcggccga gtaggacgta ttctcggaga taatgatatt 1928701 aacattgcaa ctatgcaggt tggccgtaag gaaaaaggcg gagaagccat catgatgctt 1928761 tcctttgaca gacatctgga agataaaatt gtgaaagaac taacaaatgt ccctgatatt 1928821 gtgtctgtga agctcattga tctgccataa ttaaaaaaac tcaagctata tagcttgagt 1928881 ttttttattg ttctatcccc gtgtgttttt atgcaaaata tctaagacac tccttagctc 1928941 agaaacagga atttggcctg gtgcggacgc ctcttctcca gctccaaaag tacaagccga 1929001 tccaaaaacc tcaccgctca gcctgctgat gagccctgtt gcagccattg acattgtaat 1929061 aatggggcgg tctgcatata ttgttttcat tgtatacgtc gcatcaagca gtgttaggag 1929121 atctccagta tcattcggca tgacagccat ttttggaata tgcgcgccta agtcctgcat 1929181 ttttcgaagt ctggaaataa tttcatcttt tacaggtgtt ttttcaaagt cgtgatttga 1929241 catcaccaca tagacgttgt tttcttccgc cagcgatact aacgctttta catttgcatc 1929301 tcctgaaaat aattcgatgt ctatcagatc gatgtctttt gtttggattg ccgattccag 1929361 caaagcaaga taggagcttt cgtccatctc catgctcccg ccctctttgt gggttctgaa 1929421 tgtaaataga aatagcttgt cttctaaaga tttacgaagc ttagaaatga gctttgtgac 1929481 cgcttctctg tcattcgctt tttcaaatac gtcgactctc cattcaacaa tgtccggatt 1929541 cagtaatttt actgcctctg cttcattcag aatttgtttt tccgtctttc ccatcagcgg 1929601 aatgatgatt ttcggcatcc cttccccgat ggaaactcct ttaatcgtta acacgttcac 1929661 tcgtctcaaa tcctttcaat ctttaccttg ttttattata cacgtacaac ttttttttga 1929721 aaatttctat tatatgaata gcaactaaaa aagagcctta aagggctctt tttagtttaa 1929781 ggaaatcgga tttggagcag ctggcaccgg aattgcatct gatatgtcat atttgccgat 1929841 ttttttcgtt ctggtttccg taaaggtcac ttctgtgaag ccaaactctt ttgcagtcaa 1929901 aagtagtccc tcaatcatta aaataccggc aatagaatca tcaacttctg actcctttga 1929961 aaagcggata tataagtgtt tctgtttctt cgttacagat tggacagcac ccgcttgaat 1930021 aagaggtgtc gtatcttctt ggctgctcga ttccatttcc ttaatcgctt cttttactgt 1930081 atcaaaagaa tgatttgacg gaacgagaaa gtcttgtcct tgtttatttt ggtacaagta 1930141 gtaggatcgt tttgactgtt tgggaatcga aatttccgta aaagtgccat atgagccaat 1930201 ccgaacccca gtctcatttt gatccgataa aaatttgact ttttcataag gactccattt 1930261 taaggattct ttaagcaatt tttttaacag tgtatcatct tttatagaaa atgccgtagc 1930321 tggctgatgg actcgtatac ttaattcctt ctgctttggt ttttccttta tttctacttc 1930381 atctatgaag gttggaattg taatggcatg atcaaggatg cccaattcac tactttcaaa 1930441 cagcatatcc tggatcgttt ggtctgcatt tgttttttga atgctgacgg gtatgattgc 1930501 agatgtatcg gcatcagcaa ccgctacagt gatgtaattg tcttgttcct tttcaggaac 1930561 gacaaacgat gtctgatcca aggacgatgc agcttttggg ctgtcttctg tctcagtttt 1930621 cgttactgcg ttctcttggg acgcttcttt ttgttgaggc tgtgcctgat caaagaaatg 1930681 aggagaaata atgaaggcga tataaaccgc aattgcagcg gcacacgcgg ggccaatcca 1930741 cctgacagcg ggcttatttt tacgctttgc catcgtcagc cgcttgtaaa tatcctgagg 1930801 cgaacgatgg tctttaactg ccggaagttg acttaacaac tcctttatct gttcttcgtt 1930861 ccattctgac ttcatcatcc attagctcct ccctcaaaag ctccatatgt ttccgaagta 1930921 ctttgagccc tctgtgttgg gtcgttttta ctttgctttc cgagaagcgc agagccttgg 1930981 ctgtttcctg tattgaatat ccctgaataa accgcaagat aatcacagct ctttgatcga 1931041 ttgtacattg atcaagcgca gcataaattt cccggacatt ttcatgttga accgcaagtt 1931101 cgtccggcag caattgctga tccctgacat cctgtgtatc ccagtcaaat gtaccgagta 1931161 tacgctgtct gattgtttgc tgtttacgga accagtctat cgcaacatgg cgtgcgatag 1931221 acaaaagcca tgttttttca ctgcttcttc cttcaaacgt atgataagaa tttaataccc 1931281 ggatataaac ctcttgaaga aggtcttctg tctggttttt atcctttacc atataaaata 1931341 aaaattggta caaatcttga tgatatgtat catataataa ttgaaaggtt tcttccattt 1931401 gaaacccctc cgttcacttt tttgtcgtat gaatagcttg aaaagttaca ttacaactat 1931461 attacgagta actggaattt ggaagggaat ttatattaac atatccttaa attttattaa 1931521 tgttggctat taaaaaaaca cccgctcagt cagcgggtgt ttcttatgga acaagattct 1931581 tcggcaaatt cagactcgat tttaccgttt tgtcggaata taaaaagaaa atgttgttcc 1931641 tttatctatt cggctgtgca cagtaattga tccgttgtgg gcttccacga tatttttaac 1931701 gatagccagc cctaacccgg ttcctgctct gccccttgtc cgcgctttat ctgccttata 1931761 aaaccgctca aagataaatg gcagatcttc ttccggtatg ccagacccgg agtctttgat 1931821 atcaattttc aatccatcct tcacagaatg gactgaaatg gagacactgc cgccggctga 1931881 agtatgccgc agcgcgttat caatcaaatt ggtaaatacc tgctccatct tgtcttcatc 1931941 aaacataaat tcctcttctg tgagagaaat gtcatgatct aaagcaatat ttttttcttt 1932001 cgcaacaccg gaaaacttcc gaatgatctt ttctaaaaac tcattcacat tgattttttc 1932061 ataatgtaag cctgtatggc ctgattccat tcgggctaaa tcaagcaaat cattaactaa 1932121 acggcccatt cggagcgatt cgtcataaat gatttgggca atttctttcc ggtcttcttc 1932181 agagcttgca atgtcatcga caattgcttc actgtatccc tgaagcatgg agatcggtgt 1932241 tctcagctca tgactgacat ttgcgataaa gtcctcccgc agcttatcaa ggcggcgttc 1932301 ttctgtcatg tcacgcagta cggcaaccgc tcctctgacg tgcgattccg cataaagcgg 1932361 cgacatcaaa agcacccatg atctgccttg aagcgtcatc tcaatcattt gttctttttc 1932421 agtgctgaca gcgttttgaa acagctcttt tgcttcaggc ggaagattgt cgccttcttt 1932481 gatattcatg ttctgttcat aataccaagc ctgaagaaaa cgttcagccg gcgggttggt 1932541 cacaagaatc gtaccgtcaa tattaatggt aataaccccg tcagccatac tgctcaaaat 1932601 gttagaaagc tgctcttttt cttgattgag cgcattgata tgaaagttaa gctgccggcc 1932661 catttgatta aaagcggtcg ccagttcacc gatttcatcc tgagttaaaa tcgggatttt 1932721 tgtatcgaac ttgcccttcg ccaaatcctg cgcgccttct ctcatttttc ggagagggta 1932781 cgtgaccctg cttgataaaa agaatgcgaa aaatgtggtc agcacaatcg caattccagc 1932841 ggcaagaaaa atatagcggg tcgtatgttt tgttgtatct ttaacggcaa gcaaagactg 1932901 ggataaaaag accatgcctt tctttccgtc tttttcatac gggacaccta caatcaggcg 1932961 ttcattatcc gtgtctgtat cgctcagtcc cgtccgtttg cttacttttt tatggtcttt 1933021 gagagcttta tttaagtctt tgtcatgctg tatttgctca accgtaatag acgacaggcg 1933081 atttttatca ttcggagaat accagtggtt cttctcatcc tggatgatgg caatgcttgt 1933141 taagttatca gcgagttccc aagtgattga ccttgccagt gcctggtcct cgtgattttc 1933201 taggatgaca gcaactttat tcgcaagctg tgttaaatca ttctcagctt cttccacatg 1933261 gtagttttca ataaactcca gcaaaagaac cgttaaaatg aacaatacga tcaagacgag 1933321 tgaaaggatc gtaaaccaca gcttgcctac tacgcttttc caaaatttca ttcagcgccg 1933381 acctcaaatt tataacctac accccatacg gtgacaattt ttttcgcagc ttccggagat 1933441 accttgttca gcttctctct caagcgtttg acgtgagtgt ccactgtccg taaatcacca 1933501 aaaaactcat attgccacac ttctttcaga agcttttccc gatcatacac cttgtcaggc 1933561 gttttcgcta agaaatatag aagctcatac tcttttggcg tcaggctcac ttctgttcca 1933621 tcagctgtta cgcggtgagc atcatggtct attgacagat gtgaaaacac gagcacattt 1933681 ttcgtcggtg tattggcatt gaaataagag gtttgggatg ctcttctcaa aagggccttt 1933741 acacgcagca cgacttctct cgggctgaac ggcttaacaa tataatcatc tgttcccgct 1933801 tcaaacccct gcacccggtt tgcttcttct ccttttgcgg tcagcataat aatgggtgtc 1933861 gctttttttt cacgaatttg ccggcacact tcaattccat cagtccccgg catcatcaga 1933921 tcaagcaaaa ttaagtcata attggcttca agccctttgg caatggcttc atcaccattt 1933981 tcagcttcat ctatagcata attttcacgt tcaagataca ttcttaaaag gcggcgaatt 1934041 ctggcttcgt catcaactac taatattttt gtttcgttcg tttggtccat gttttccccc 1934101 tgctttcctt ctgttacttt cattttatca aatcgtgaga aagtttgaga actgtgtcgc 1934161 tttcaaagga ctatgcataa gaatgaagtc cggcaagcac aagatttacg aatattaaat 1934221 taaacataat aatagcaaaa ccgattacgg ccagccatgc tgacttctca ccgtgccagc 1934281 ctcttgacag tcttaaatgc aagtaagcgg catagaacaa aaatgtgatc agcgcccata 1934341 cttccttagg gtcccagccc caaaatctgg tccacgcgag ctgagcccaa atcattgcaa 1934401 agatcagcgc gccgagtgta aagatcggaa atccgattga tacggccctg tacccaacct 1934461 catccaccag atcaagattg acgtttttca ccagcggatg taatagagcg ctgattcttt 1934521 ttctgatgat cagacggaga gccccataca acacaagacc tgctccaaat gaccaaatga 1934581 cagtgttcac ttttctgcct gagaaaagcg cgggaagatc aacaagcggt tccattcttc 1934641 cttcggtcaa aagctctccc tgatgcggac cgacaagcgc gggcatttcg tacaccatca 1934701 cgcttttttc tttacttttg tccacccagt taaactccgc ttcatagcct gcaagacgaa 1934761 atgccgatgt gattgcaata aaggcgacgg ttgtgaccag gataaacata atcgcttcaa 1934821 gccagaaggt ctttttgctt ggctttgtct ggtctacatg cttcaaaaga aagatgacac 1934881 cagcgacaaa gctgatggca agtatagctt gcccaagcgc ggccgttgtt acgtgaatat 1934941 acagccagtt actttggagc gaaggaatta aaggcgagat atctgtcgga aacatgctgg 1935001 cgtaggcaat cagcaataaa gcaattgaca gcgtaaacag gcctaatgaa ggcaatctat 1935061 agagaaaata aagaatgata aacgccaaaa caagcatcat gccaaaagcg gtggtgaatt 1935121 caaacatatt gctgacaggc gcatggccgc ttgcagccca ccttgtgatg aaatatccta 1935181 ggtggcagaa aaaaccgaca atagaaaggg tgattccaat gttggcccat cggtttggcc 1935241 tgcccttttt atctttattc ccgcgtatgg ccccgccgaa gattgggaca gcgattaaat 1935301 acacaagaaa ggccgcataa agaaaatttc cgctcagctc tgccatgaca tcactccctt 1935361 ttcgcctatt tctgtgtttt gattaattct ttttggtcca ccggttcagt cagtccggaa 1935421 tcagccaata taaatgctaa atccttcttc aggccaaacc agtttttatt ggtatgccct 1935481 gctaccataa ctgcaccgtc ctgtgagtgc agccaaattc ttcgatgctg ccagtacata 1935541 ccttgaatga caccgatcat aaaaatggct ccgccgacag caagcaccca gagtgtcaga 1935601 tcctttctga ctgtaagtcc agtaatgttt ttcgtttcga catggtcaaa tttcagcttg 1935661 tatttattat tgcctgatcc ttcgatggtt tcttggatgg cgacaaagct cttttcgcct 1935721 ttcggtttgt ccggcgttat gatattaaag acaaaagccg gattgttagg gatctttgtt 1935781 tttgtgctcg gctctccgtc ctgattaaaa tagaagtcag gcaggtagct ggcgatttcc 1935841 accttgtaac cgttaccaag atcatagact gaatctggat ccagaaggtt gatcttcagg 1935901 ctcccaaagg atttttttgt ttttttatca atcagctgga acaccatttg gtcaagctga 1935961 ttctctttgt aatccacctg gtaaacggaa aaagaatcaa aacgcagcgg ctgattgaca 1936021 cggatgtctt cttctgttac tttttccagc ttcggcttct cgccataaac aatttttcct 1936081 tctctcttgt agagtacggc atcagtttga aagttctttg ccactctacc gtccccgact 1936141 ctgtcaatgg catctgcaaa tacctttttt tccgttttgc tgttataggt ctctacgctg 1936201 aattgattgt ttttcaaata atattttccg tctgtacccg gaattgctgc ggtttcgcct 1936261 tctctgaccc aaagcgtctc atcgacgtac atgccaggca caaatctcag catcgcacca 1936321 atcagaaaga tgatcaatcc aatgtggttg acatacgggc cccagcggga aaagcgtcct 1936381 ttttcagcaa gaatgctgcc ctctttttct ctgattctat aatgtttttt ctttaataga 1936441 gtaactatct tttctttcga ttccccgttc agtacagtaa ctgtttcact gaacaagcgc 1936501 tgccttctta aaaaggccgg gctccttctg acaccttggt tttttaacgc tctatacaac 1936561 ggaatgaccc gatcaaggct gcaaatcacg agtgaaatgc cgatcgaggc aatgagcagc 1936621 aaataccacc aagaaccata taaatgatga aacccgagca aataataaag ctggccaaac 1936681 gtgccgtact gctccttgta ataagtatca gcctgtgcgc ccggaggcag ataggcttcc 1936741 tggggaaaaa tggtgccgaa cgctgatgcg gcaagggtta tgacgataag ccatattccc 1936801 accttaaccg aggaaaagaa attccaaatt ttgtcgatga tcgttttgtt ataggtttgc 1936861 gaacgtcttg cgcttccgtc atatctcata tcagcgagcg gaggttgagt ttcctgaaga 1936921 gctcttccgc acgattcgca taaaacggtt ccgaccgggt ttatatgtcc gcattcacat 1936981 ttgacttgct tcatcccgaa gtctctccgg gttttatgag attcatataa tcgtgtatca 1937041 tgctttctgt catagtgccg gtcaccacct tgacaacttt tccttccgga ttgatcaaaa 1937101 aggttgtcgg aagcggagat acgtcatagg catcaagcac ttggcgatct gtatccagaa 1937161 caaccgggaa attgactccg taggatttca taaaattatg tactgctatc tttgactccc 1937221 caacatttac agcgacaatt tcaacacctt ggcttttaaa atgcttatat tggtttgcca 1937281 tataaggaaa ctcttttttg cacggttcac accatgtacc ccagaaattc aaaaaaacac 1937341 ctttcccttt taagtcactg agctcgatac gtttcccatt cgtatcctct aggacaaaat 1937401 tcggtgcgtc ggacccttcg gatatactct ctttgccggc aaatacagcg ttgtaaatgg 1937461 tatagccgag tgcgcagatt aaaacgagaa ggatgccggt ccgaatgaat aaacgccttt 1937521 ttttcttcat tgtccactgc ccccttcccc ctattgcaga tccattcaat tatatcattg 1937581 cacgttcatt tcacatttct tactttttga aggttatgtg aaatttagaa agcgttttta 1937641 ccgtgatccg ccagtgctct gagccttttt acttcgtgag gcgtaagctc tctggcatcg 1937701 cccgtgtgca ggcctcgcag gtttaaaaac gcgtattcct cacgcttcag cttgattacc 1937761 tcatgtccga tcgcttcaaa catgcggcgc acttgtctgt tgcgtccctc atggatcgtc 1937821 agctgaataa tgcttgtctg ctttttctta tccaaagaca gcagcttcgc tttagcaggc 1937881 gctgttttgc cttcctccag cctaattccg cgctccagct ttctgagcag ctctttaggc 1937941 gggattcctt tcaccttcgc cacgtatgtt ttgtctattt catacttagg atgcattagc 1938001 ttattggcga attcgccgtc attggttaaa agcaaaagac cgctcgtatc atagtccaga 1938061 cgcccaatcg gataaatgcg ctgcggaata tttttaaaaa agtccgtcac cactttgcgt 1938121 cctttatcat cttgcgctgc ggaaataacg cctcttggtt tatataagag aaagtaaacc 1938181 ggctcttcgc gttcaacctt taacccgttt acctcaatct gatcagaacc ggtgacctta 1938241 acacctagct ctgttactac tttgccattc acctttactt ttccttcttt aatcagctct 1938301 tctgcctttc tgcgcgacgc aactccggca tgagcaatca ctttttgcag tctttccatg 1938361 tctttcacct caagtattat cttacttttt tcaaccttaa caaacaagct ttttcaaatt 1938421 cctatgccaa atctaaaaaa aacgccgttt tcaggcgctc ccaaataata acgtaacgat 1938481 gatgatagat gcaactacgc cgattaaatc tgcaagaagt cccaccttta atgcatcacc 1938541 cattttttta atgccgactg ctccgaaata cacagtcagt acgtaaagcg ttgtatctgt 1938601 agatccctgc atgacggaag ccagcctgcc gataaaggaa tcgggcccgt atactgcaat 1938661 taaatcggtc gtcattccaa gtgcggccgt accggagatc gggcggatca gagcaagcgg 1938721 cactacttca gcagggatgc cgatagcgga gaaagccggt tttaaaagat ccattataaa 1938781 atcaagcgcg cctgatgatc tgaaaacagt tatagcgaca agcattccga ctaaataggg 1938841 gataatggaa aaggcaattt ctatcccctc tttcccgcct tcgacaaacg attcatatgt 1938901 cggaaccttt ttgatcgttc cataaagaag aattccggca ataatgattg gaatcatggc 1938961 taaagacagc cagttgatga tttccatccg ctcaccttcc cttctttttg cggcggtaat 1939021 aaaaataccg atcaatgata atggcaccga ttccggaaat aagcgttgcc aaaatgcttg 1939081 gcccgacgat atctgtcggc gttttggagg aataagccat tcggacagcg atcaccgttg 1939141 tcgggatgag tgtgatgcag gacgtattaa cagctaaaaa agtaatcatc gaccggcttg 1939201 cttccgatcg gtttccgttc agctttttca tttgttccat tgctttaatg ccaagcggag 1939261 ttgctgcatt tccgaggccg aagaaattcg ccataagatt agataaaata tagcccatcg 1939321 ccgggtgatc cggcggtata tcagggaaca gtttagatat aaaaggtctg cacatccggc 1939381 tgaaaatatc caaaagccct gactgctcgg cgattttcat taagccaagc cagaaaacaa 1939441 gcacgctcat caatccaaat gagatcgtaa tcgcttcttt cgcaccctta aacacggctt 1939501 catttacatc ttgcagagtt ccgttgcaca tcgcaaaaac gagtccgatc acggttaaac 1939561 tgacccaaat tatattgacc attttgctcc gcctgccgca ttcagaaaga ttgatttaaa 1939621 cgtttcaaaa aattgtttct tcggtttttg atgccgctca ttttcataat agatcggcac 1939681 ttttgcgatg gttgcatcgt tgaacatgat ctccatgtgc cctacgatgt cagggatttt 1939741 cgaggcatct ttttcccatg cttttttcgg cttgagcagt gtggtattaa tttttacatt 1939801 ttctttttcc tcttcggtca gcaaataggt gatatcacgt ttgataaaag ccttcgattc 1939861 ataaaatgtg cctttcagct ttggaatatc cccttttttt gcaattaaat aggtttgata 1939921 atgctcaaac acatagttaa acatcttcat atggtcatcc caatcattag ggtcattaat 1939981 ggtgacggct atcaggtcaa tgccgtcctt tgaagccgta gagaccagtg tccgttttgc 1940041 aagttttgta tagcctgttt ttcctcctgt gctgtacgga taaagcatgg tcagcagttt 1940101 gtttttgttt ttccatacgc tttccatcgt ttccgctttg tatatttttg tgcctgaaat 1940161 cttttgatag tctttcagct tcatagcata cttagttaaa atggccatgt cataggctgt 1940221 tgaataatga ttttcatggt cgtccaatcc gtgcgggttt tgaaaacggg tgtttttcat 1940281 accaagctgc tcggcttttt gattcatcat ataaacaaac ccatcgaggc tcccaccgac 1940341 atgctcagca atcgcgacag cggcatcgtt tcctgatctt agcatcaggc catacacaag 1940401 atctttcagc ttcacttttt gaccttctgt taaataaatg gcggagcctt ctgttctgac 1940461 agcatttgcc gaaaccgtca ctgtttgatc cattttgccg gattcgatgg cgaggacggc 1940521 ggtcataatt tttgtgatgc tcgcgatccg ccttttttga tgctcatcct tggcatataa 1940581 cactctgcct gacgcaccgt caataatgat cgcgcttttt gcactgacat ctatagcagc 1940641 atgtgctgta ttcacattta cggttgcaat aagaaaagaa atcatgatca cgaatactgc 1940701 ttttttgaaa atgcgcatgt ttgctcacgt ccttgtggtg gtttgtacaa gtttatgcgc 1940761 atgtccatca gttatgaata acaattatat ttctggaagc aaacataaaa aaactctccc 1940821 tgaaaaaggg agagtaaacg ttatctgatt ggcgccatgc ttgatccgga cgcttcgtaa 1940881 tgagccagct cttccctcat cttcagaaag gccgcgctca acggcaataa taattgctca 1940941 agcgacgcag gaacagcatg ataaaactca attgcgctga ccccggtata agacgcccgg 1941001 ctattttcac accacgtgtc ttttttcggc ataaagaact cttcaatgca ttggtgatac 1941061 acattataaa gtgttttttc cgctctggct tcctgaaaag gctcctgcat caggagacga 1941121 cggcacgctt ctgcgcctcc ttcacaaaat actgccattc ttctcagagt gctaagcaca 1941181 tcacagcagt atcctttttc aataggcaat tcagcctgta aggactcaag cgtcgtttga 1941241 tttaggtaat cgttcacggt attgacaacc attgataaga attcgcctgt tttttgagtc 1941301 tgcgctcgca caatcgaatg tcccatttcg tttggtatct tcccctcatg tatttgtctc 1941361 tcacattttg cttctttcat gatagcttct tccttatatc ttatgatgat gaaaaagcgc 1941421 gattcattaa acttctattt tatatcttcg aaggtttggt taaagttttc aaaaaataaa 1941481 tctgcttctt cttgaagaac gtcttcttcc gcattttcag gcagcggcgg aagctcgtcc 1941541 agcgttttca gaccgaattg ttcaagaaaa gtcggcgtag taccgtataa aatggcccgc 1941601 cccggaccat cggcacgccc tacttcacac aatagcgcct tcgcgacaag actgtgtaaa 1941661 atccgctctg attttactcc tctgatttct tcaatttctg ctctcgtaat tggctgtttg 1941721 tatgaaacaa tggccagtac ttctaaagat gcttgagaaa ggccctttga cggcacttca 1941781 atcagttttt tcaagtaagg cgcaaagtct tttttggtag agagcatgta cgtatctgca 1941841 tactcaataa gttcaatccc tcgtgtatct ccgcggtatt cgtccgccac atccgccatg 1941901 atcgtgttca gttcaggctc ttcgatttca agcactgtta acagctgctt ttttgtaagc 1941961 ccttcatcgc ctgccgcata aagaagggct tccacaatag ctttccaatt cacgatatca 1942021 agccccatga atggattcac tccccgtaat gtaaatatct gaaaaattgt gctcctgttc 1942081 aatgaggacc agctgatttt tcatcagctc aagaacagct agaaaggtca ctactaaatg 1942141 ttctttttgc tcatatggaa acagatccat aaagttaatt ctcgttcctc tagatttcaa 1942201 gctgtgcacg atttcgttca ttctggcttc gattggtatg tcctgtcttg taattgttgt 1942261 ttccatcggc ctgtttattt ttttgcgttt cagcactttt tgaaaagctc cgatcatatc 1942321 atagaccgtg acagagagct tttgctcaga ctgttttact tcttttgcat attcactcaa 1942381 atcactcggc ggtttcgtga acgatttttg tctttcttct tcccgttctt ttaaatcctt 1942441 cgccgcatct ttatattttc ggtactcaat cagcttttca atcagttcct cccgcggatc 1942501 ttcttcttca agtaattcat cttcaaaaag ctcctcctct tgcttcggga gcagcattct 1942561 gcttttaatg ctgagcagcg tggcagccat aaccaaatac tcgctggcaa tgtcgagctc 1942621 aagcacgcgc atcgtatgta catataataa atattgttca gtgatcttcg ccacaggtat 1942681 atcatatatg tcaatttcaa gacgattgat taaatgaagc agcaggtcca atgggccctc 1942741 aaacgtatca attttcactt gatattcttc catcatctca ccattttcaa gtatcactct 1942801 cattgccgga aaaactggct accctatagt ataagccacc aaaaagctct cgtccaatac 1942861 tatttcatat cctgttttga aggagtttgt acagaatatt caaaacacaa gaggtgtttg 1942921 ctcggagcgc agaagcggga gaaaaagcct ttgcttctgg ttttcctttc taagaagcac 1942981 tagaggccgg gcgttctttt ttccttttat cccttctatg gtacactaaa agcacattaa 1943041 aggaggaagc accttgtatc cgaaagctta tatagattat ctcgttgagt ttcatgcgac 1943101 acgggattat tttgaatgcc atgaaatatt agaagaatat tggaaggaag atccgccaaa 1943161 gaaacgaaaa cgctattggg tgggctttat tcagcttgca gtggctttat atcatcacag 1943221 aaggcagaat acagccgggg caaaaagact gatggcgaac agcatccgga ttcttcaagc 1943281 agaacaccgg gcagtcgaag acttagggct tgatcatggc cgtttgctcg aacttatgca 1943341 atcggtttac gaacaaatcg aaaccgtctc tgcctataaa agcattatac tgccaatcaa 1943401 agatgagaaa ctggaggaag catgcaggat cgaatgcagg aaaaaaaagt atacatgggg 1943461 gcagcccagt gcactcagca acatatttct tatcgacaaa caccgtttgc gggatcggac 1943521 tgacgtcatc cgtgaacgtg aaaaagaaat agaacgcaga aaaaaaagca gagactgatc 1943581 acagcctctg cttaattatt gtatgaaatg tcttgatcct gctgaccttg acaacgttcg 1943641 aaaaagctct gcgttaattc atttggaacc agtacttgcg ttttgaataa atgctttaaa 1943701 gcatccatca tctgttttcc gattccttga tggcgatgag aaggattcac actgatatgc 1943761 cggatctcaa cctcagaatc ctttttttcg actccgattg ctccgacgat atcctcgtcc 1943821 tctttccaaa gaaagagctg gcggtctgta tccgtttcgt agtccttaat tgtctgctga 1943881 agctgcttaa ggtctttttc attcggcata aacgaaagaa gccccatcgc aatcttttca 1943941 aacgattttt tataacgaat taacataaaa acccctctat atccaaaatg tccagtctgc 1944001 tattaacgga tacgaatagg tgatccgttt tctcacatta tatcattttc gccatatttt 1944061 taaactgttt tcagcaaatt attcaaatga gcggtttaaa tttgccattt caatggcaga 1944121 aacagcacaa tctacacctt tgttgcccgc ttttgtgccg gcacgctcga tagcctgttc 1944181 gatgttttca gttgttacaa ttccaaagat gacaggtaca ccagtagtgt ttgctgcttg 1944241 cgcgatgcct tttgcagctt cattgcagac ataatcgtaa tgtgtcgttg cgcctctgat 1944301 gacagtgccc aatgtgataa tagcatcata tttttttgtt tccgccattt ttttcgcagc 1944361 aaacggtatt tcaaatgcgc ctggaaccca agccacatca atgtcatttg tgtctacgcc 1944421 atgtctgagc agcgcatctt ctgctccgct cagcagcttg ctcgtaataa aatcattaaa 1944481 tcttcctact acgattccga ttttaagacc tgtaccaact aaatttcctt gtatgatatt 1944541 catatgattc ccatcctttt ttgtgatatt tgtgattaga aatgaagtaa atgacctagc 1944601 ttgttcattt tggtttgcaa atatttttta ttgtgttctt tcgcctccat ttgaagcggc 1944661 actctttctg aaatactgag tccgtagcct tcaaggcctg cgatttttcg cggattattc 1944721 gtcaaaagct tcatattccg gacaccgagg tcgcgtaaaa tttgtgctcc gatgccatag 1944781 ttgcgaagat ccggcaagaa tccaagcgcc tcattggctt ctacggtgtc atagccttgt 1944841 tcctgaagct tataagcttt taatttattg attaaaccga tgcctcgtcc ttcttggcgc 1944901 aagtacagga gcactccacg gccttctgcg gcaatttggt tcagcgcggc gtgcagctgc 1944961 ggtccgcaat cacagcgatg agagccaaac acgtcacctg tgagacattc tgaatgcacc 1945021 cggaccaata ccggttcttc tccgaacggc acatctccca tcacaaatgc gacatgctct 1945081 tttccatcta cctcatttgt gtatccataa accttaaatg tcccaaaatc agtaggcagc 1945141 gtaatgtcaa cttcacgctc gacaagtgtt gtcagattgt aacggtattg aatcaaatcc 1945201 ttaatggtga tcatttttaa ttgatgcttt ttcgcaattt caatgagctc aggcactctc 1945261 gccatcgttc cgtcttcatt cataatttca caaatgacgc cggctcctgg agatccgcaa 1945321 gcttcagcaa gatcaacagc agcttctgta tggcccgctc ttttcaggac acctcctttt 1945381 ttcgcaatca gtggaaaaat gtgccccgga cgctgaaaat cagatggcac ggatttgctg 1945441 tccagcaatg cttgaacggt aaaagatctt tcttgagcgc tgatacctgt cttcgtttca 1945501 cgatggtcta tgcttacggt aaatgcagtg tggtgagagt ctgtattatg ctcaaccata 1945561 gggtgaagat caagcctgtc tgcgatttcc tcactgagcg gcgtgcagat cagtcctctc 1945621 ccatgtgtcg ccataaagtt aatgacttcc ggcgttgcat gctcggcaag agccacaaag 1945681 tctccttcat tttctctgtc ttcatcatct acaacgatga tgacttcgcc tttttttaaa 1945741 gcgtccagtg cttcttctat cggatgaaac atgcaaatct tcctctctaa aagccgtttt 1945801 cgcttaagaa ggcttttgta atggtttgtt gggtcttatt ttcattggct ttatgcaaaa 1945861 atcgatacat atattttccg atcatatcgc attcgatatt cactttagag ccgatcgttt 1945921 tttctgaaaa gatcgtttcg ctgatcgtat gcggtattaa ggagatcgtc actgtgtctt 1945981 ctgtcaggcc gaatatggtt aagctcacgc catccacagt aattgatccc tttaaaacca 1946041 atgtttttgt taatgacggg tccattttta aatcatagta aactgcgttg cttttctctt 1946101 caattcgtgt gatttccgca gttccgtcga catggcctga gacgaaatgg cctccgaaac 1946161 ggccgtttgc cgccatcgct ctttccagat ttactttgct tccttttgtt aaatcattca 1946221 gtgacgtagc tttgactgtt tcaggcataa catccactgt gaattgattt tttgtaaaat 1946281 cagtgacagt cagacaaatg ccgttcactg caatgctgtc gccaagatga acatcctcta 1946341 aaatctttga gcatttaata gttaaggcca ttgcatgccc tgcttttttc atggattcga 1946401 ttgtgcctgt ttcttcgata attcctgtaa acatggtcac catcctattc ctttgtcggt 1946461 tttgccgtca gtttgatatc acggccgatt tgggttatat cagtgaattg taataagggg 1946521 acatctttca ttgattgaaa accttcaccg gagattaagc tgggagcatg cgttcctccg 1946581 attagtttag gggcaaaata gaagatgatt tcttgaaaac agccttcttt gacaaagctt 1946641 ccgtgaacag ctgaaccgcc ttccacatac accgacatga tgccttcttc cgctaggatc 1946701 ttcaaaacat caggaatttg aatgcgctcg gtttcaagtg taaatatgtt cactccgaaa 1946761 gctgaaagcc gttttttctt ttcctcgtct gcgcgtgccg tcgtaaaaat ccatgtcggc 1946821 gctatttgat cgcaaatcac tttagcgtcc tcaggaatcg agagtacggt atcaagtatg 1946881 acccgaaccg gctgttttgt tacattcggc agtctgcagg ttaagctcgg attgtcggct 1946941 ttcactgtgc caactccgac taaaatgctt tggtgtgttt tcctgtattg ctgagcatcc 1947001 tgtcttgcag cctctgacgt gatccatttg ctgtcacccg tgctggtagc tatcttgccg 1947061 tcaaggctgg cagccgcttt tagcgtgacg tacggaaggc ctgtcctcat aaagtgcaga 1947121 aatttttcat tcagcctctc cgcctggtct gccaggatgc cttcccttac ctcaatgcca 1947181 gcttctttca tcatgctgat ccctcttcca gccacaagcg gattaggatc tctcatcgcc 1947241 acgaacactc ttttgatacc agagttgata atcaattctg cacatggcgg tgtttttccg 1947301 taatggctgc acggttcgag tgtaacgtaa atgtcggcac cctctgcatg tgctccagcc 1947361 atatggatgg catgaacttc tgcatgagct tcaccatatt ttaaatgggc gcccattccg 1947421 acaatttgtc cgtcctttac gacaacagcg ccgacgagcg gattggattc ggtctgtcct 1947481 tcgccctgct tcgcaagatc taaggccagc ttcatataat actcttccat ttgtttccct 1947541 cccctctttt gttatttacc gtcaaaaaag ccccgaattt ataaaaaatt cggggcttta 1947601 ggtattttac gcaataggaa ataacactat gcatttttaa acattttgca tagcggctca 1947661 tcatccttct cccatccaga ctttcactgt cggcttcagc ttaaactgaa tccaccgcgt 1947721 gcttatgcac acgggtcacg ggctctaaag caaatgtgct ttactaccgc cggtcgggat 1947781 ttccaccctg ccccgaagga tacaatcttt attcatttgt ccttattggt tattatagcg 1947841 atccttttta aagtacgcaa tgaaataaac ttacaatttg agaaaaacaa aacatcaccc 1947901 ttcgatccga aaggtgatgt tttttaatca ttcacttttg caaccttgat taatccgtcg 1947961 atccgctttg atttgctgaa gtaagcctta atcttgtcac cttcttttat atcagataaa 1948021 tcctgattta atttttttcc gttgaagatg attttcgttc cgttttctgc tactccatga 1948081 tactctgagc cgtcaatttt cgtcacttta tattcctgga tggtgtattc ctcttcttcc 1948141 gaggacaagg tttgtccaat tgctgtcgga acatccttca gctcaatatc atttatgtac 1948201 atataaccgc ctgcaagtaa aagcaaaagc actaacagaa tggtaatctt ggtttttatt 1948261 cttcccattt ctaaacctcc agccaatatg aatctattca ttcatatgag ttattccttt 1948321 ttttcatgaa taaaaaaccg taaattctcg taaattatta atataacgat gcataacggg 1948381 aatatgtttc acatttctgc aaaaatttct tttctataga tatacgaatt tatgttctgt 1948441 ttttagggga tgaccgtaaa aaagatataa aaaaagcagc cccaatggga agctgcttga 1948501 tcctaatttg ttttgcgcat ttcgttaaac gggtagaaaa caaactttga cgtacccgca 1948561 atttgttttt tcgtgaagag gccaaggccg ttacggctgt ccatggaatt gcgacgattg 1948621 tcacccatca caaaatactt gttatcaggc actttaaccg ggccgaaatc atcggtcaaa 1948681 tggtcaaaac cgtcctgttt cgctctcttt ttattagccg ccaaataagg ttcgtccacc 1948741 tttttcccgt tgatatagag ctggtcattt ttcatctcaa ccgtatcgcc gggaaggccg 1948801 ataatacgtt tgacatagtg aacatcatct ccgtttaaca cgacgatgtc tcctctatca 1948861 aactcgccga tgtatttgac tgtcatatta acaaaaaccc tttcacggtt gtgaagtgta 1948921 ggatacatag agtcaccatc aacgacatac ggcgcaaaaa taaagttgcg gatgagcaaa 1948981 gcaagaacga cagcaatcac aattgctttt gcccattcta atattgactt tttcttcgaa 1949041 acattttctg atttcaactg atttcctcca ataaacaacg gtcttcaatt tatgttatca 1949101 cgaatcgaaa aaaaatccca ttaggaccat tgaagtgatt ttacaaactg ttaatcttca 1949161 tcttctaccc acatcatgcc tattttttct tgtcgatcat aactaggcct gaaaatattg 1949221 aaagaaatga atcgcataat tcagaagcga tggactcaga agaaagagag ttctcatatg 1949281 caaaatcttt agatcgtata taaagcatga ggttacgggc agtttgttca tttactgcat 1949341 tccattgatc tcccagtcca tgatacccat ggcacttgac aaaacaatta acgtcatgaa 1949401 ggttactgga atgtttgcgg caacctattt cacaggtgat aaccgcaccc cgttttttgc 1949461 tttcataata tgtttaaaat cattcaagct cgaaaacatg gatcagcctc caaaaaataa 1949521 atccaatata ttcccggcag ttgaagactc tttattataa aactctgaat atccgcagtt 1949581 cttacagtaa accactagaa atcggttatg ctgcacgtca aacagctttg ataatcccgt 1949641 gccggttgta gctatttctt tttgtccggc ttcagtacta ccgcatttta tacagccttt 1949701 gttgttcata tcgcgatctc cttttcatta catcacgttt gtttgattta ttttactaca 1949761 aaatatcaat cccaatgacc cgtactactt taaagtttac ttaattttga ttacatacta 1949821 attgggttcg tttctcagct tggtaaatct tctggagaaa cggaaaagct ccatgaccaa 1949881 aacattcaaa ctcagccaaa caccgccgaa ggcgtaaccc gcagcaacat cactcggata 1949941 ctgctcataa agtacacacg gctcagcccg atgaggaata aaacgataat aaacaaaaaa 1950001 atgcaacagt ttgcagacgc gtcttgtgag aatgacgaac aaaaagataa gcacaaaaac 1950061 caaaaatgac aaatgccgtt aaagtctgtt cgctcgggaa tggatataat acatgacttt 1950121 ccaaaggagc gtgaacagga tgaagggaat gaaagagccg tctgattccc tcttcataaa 1950181 gctccccacc aatgactagg aaaaataaga aagagagttc gattttccga tcttgccctc 1950241 tgaataccgt ccaaaaaaaa gttagaacaa taacggctaa cagaacacct ctcgacgcaa 1950301 aagctttctg aattgcagct gggcccagtc tatacccgat ccaatacgac atgctcactc 1950361 ccacagctcc ccaatccggc cgctaacatg cttagcaccc agtttaactt ttcttgaaac 1950421 acgagaacac cggcaaactc tcccggtcca agtaaagcta gaagctctaa catcaagaca 1950481 ataaacaaga cggcatatcc gtactgttcg agcaaccccg tcaaaacttg catgtgattc 1950541 tccttaaact tttttgttct tttatcattc ccaatccact ttttgtataa tcagcacaat 1950601 tttatcttca gtcgtccaac aacattgtct atggcgggat cttctctcat acattctttt 1950661 ttgacatagg aggagcaata gcatgaaatg ggaggaaaca aaagatacgc agggagtttg 1950721 ccaaaatttt gggcagttcg ttctgccacc gagtcaggtg tttgtttgcc cacctcatcc 1950781 cttgtcaatt ccccattttt cccgtttgag gttcgaaatg gtaaagtatt tcacttagtt 1950841 tcttacatga agaggtaaat tctttgctca ccgaactagg atagcggcgt atggcgattt 1950901 ctacattgca taaccactgg ttatttagtg agccgtgagc aatgtatatg cactttgagt 1950961 cagcacagga tgatcctatt acattcgcca gaaaagcagc tgccgcattc agagtagtta 1951021 aaagaataga cagatatctg ggcttccgga agctttaaag gaggctcttt tttcgagcat 1951081 ttttataaat caataaaaac aggcatctcc taaatatttt tgccgataag tttacgctaa 1951141 tcaactctag cactaataca tataaaaaat agaatgatat gaaaggagac ttgatagtat 1951201 gattgattat cctattaata taaacaacgt ttccgggaac agtgtaatta acgtaggcgg 1951261 cgcttttatg atcaggcctt taactttgtc caaatctgtg tttggctccg gaggtttaaa 1951321 cacaggaatt gtctttgaaa ataactttgt aagcaaagct aaaatgatta atcatcaatt 1951381 tactgatcaa aacgtcacca aaacttttta atgtattcaa tacacggggg tcactaacta 1951441 aacacctggt tttgccaacc gccatcagca ttcggcggtt ttttattgaa catttttggc 1951501 caataaaaaa agcttcctct ctaagaggaa gccttttgcc tgccgattag ccttctacac 1951561 gaacttcttt catgacatcg ccattagaca tgtttttcgc gaattctaat ccgcttgtta 1951621 ctttaccaaa tacagtgtga acaccgttca aatgaggctg tggctcatga acgatgaaaa 1951681 attggctgcc gccagtgtct tttccggcat gtgccataga aagtgcgccc gcctcatgtg 1951741 tatgcgggtt gccttctgtt tcacatttga ttgtgtatcc cggaccgcct gtaccagttc 1951801 cgtgcgggca tccgccttgg ctgacgaagc cagggatcac tcggtggaat gtaagcccgt 1951861 cataaaagcc ttcgttcgca agcttttcaa agtttgcaac agttccaggt gcagcttcag 1951921 gataaagttc aaattcaatt ttgttcccgt cttctaataa aaagtaacct gttttcaatt 1951981 gtatgcctac tttctttatt ttaattttca aaggagatta tgtataggtt atagcctgtc 1952041 tctccttgtc gcggctatta taccacacct ttcgggggaa aacgaatctc ccgagcttta 1952101 ctaaaaaata aaaatgaaac ctgaatctct ttatctccgt ctaacctaac ggaactgtat 1952161 ttttcatgat tcaggtcctc acaaagcagc actatccagc tgcttgtgaa attgaaggag 1952221 gtcaaactgc tttgaagaaa atttggattg gaatgctggc agcggccgtt ttgctgctga 1952281 tggttccgaa ggtcagtctc gcggatgccg cagttggaga tgtcattgta acactgggtg 1952341 ctgatttgtc agaatctgac aaacaaaaag tgcttgatga aatgaatgtc cctgataatg 1952401 ccacaacggt aaccgtgacc aataaggaag aacatgaata tttaggaaaa tatatatcga 1952461 acgcgcaaat cggatcgaga gcgatttctt catcgtcaat caccattgcc aaaaaaggct 1952521 ccggattgaa tgttgagacc cataatatca gcggcatcac agatgaaatg tacctgaatg 1952581 cactgatgac agccggtgtt aaagatgcga aggtgtatgt tacagcaccg tttgaagtat 1952641 ccgggactgc cgctttaact ggattgatta aggcgtatga agtttcttct gacgaagcga 1952701 tctcggagga tgttaagcag gtcgccaacc aagagcttgt cacgacatca gagcttggag 1952761 acaaaatcgg taacgaaaat gcggcagccc tgattgcaaa aatcaaagaa gagtttgcta 1952821 aaaacggggt gcctgataat aaagctgaca tcgaaaaaca agtggatgac gcagcttctg 1952881 atttaaacgt cacacttaca gacagccaaa agaatcagct tgtctcccta ttcaataaga 1952941 tgaaaaacgc tgacattgac tggggacagg tcagtgacca gctagataaa gcgaaagata 1953001 agattacgaa attcatagaa tcagatgaag gcaaaaactt catccagaaa gtcattgatt 1953061 tcttcgtatc tatctggaat gcgattgtat ctatattcaa ataagaaaag cgccgaaaaa 1953121 tcggcgcttt cttttattgc tttacacccg ttttaaatgg cagatcaagt tttacaatat 1953181 cttcgtatgt ttctcgcttc acgactaaat gagcctcacc gttttcgaca aatacaacgg 1953241 cgggtctcgg aatacggtta taattgttgg ccatgctgta tccataagcg cctgtacaaa 1953301 aaacggcaag aagatcgcct tcttttactt ccggcaggtc aatatcccaa atcagcatat 1953361 ctccgctttc acagcacttt ccggcaattg ataccgtttt gtcatgcgct tctccgatcc 1953421 tgttggctgc cgcagcttca tatttagctt ggtaaagcgc aggacgaata ttgtcgttca 1953481 tgcctccgtc tacagccaca tattggcgga cacccggcac ttctttttga gagccaaccg 1953541 tataaagagt tgtgcctgcg tctcccacga gagaacggcc cggttcgatc caaatttccg 1953601 gaatgtcaaa accgtaacgg gaagcatttt ctttcacagc ttcgataatt ttttcaacgt 1953661 attcagtggc atgaagcggt tcatcatctt ccgtataacg aatgccgaaa cctcctccaa 1953721 gattcagcac cttggataca aatgaatatg aatctctcca ttcgtctagt tttttgaaga 1953781 ttttttccgc tgctaacaca aaaccggccg tatcaaagat ttgcgagccg atatggcaat 1953841 ggacacccag cagctgaatg tgttccgatt gtaatacttg ttcaatggcc cgttcagttt 1953901 gtccgttatg aagatcgaaa ccaaactttg aatcttcctg gcccgttgta atgtagtcat 1953961 gcgtatgcgc ttctactccg ggcgtgatcc gaagaagaac atcgatggag tgacccgttt 1954021 ctttacatag gtcttcaaga agcgcgattt catagaaatt atccaccaca atgcagccga 1954081 tgcggtgctc aagcgccatc cgcagttctt ccctgctctt attgtttcca tgaaagtgga 1954141 tgcgttctgc cggaaagcct gctgcaacag ccgtatatag ctctcctccg gatacgacat 1954201 ctaaagaaag tccctcttcc tcagcgagct gaatcattgc gactgatgag aatgctttgc 1954261 tcgcatatgc cacctgtgct ttcagccctg cagaaataaa cgcctgctta aagcttttag 1954321 cacgctcacg tattaaagcc acatcatata cgtaaagagg tgtaccatat ttctccgcta 1954381 aatagagagc atccacacct ccgatttcta aatgaccatg ttgattttgt ctgcttgtgc 1954441 cgtgtaagaa caatgtcatt ccctctttct ccgcttatgg atgaaaggac agttttatgg 1954501 actgtccctt cataattaag acatacatta tcatactctt cagtcagttt caatgcgatt 1954561 atgaattggt aggctgcctt aagcgatttt tggggtgaac gatgctgggt cttacttttg 1954621 cgccaggttt cgctgtgcgg acaagaacct gccacagcgc ctttccgtta aagggaatca 1954681 gcggccataa gtacggtgtc tgaagggatt tgatgcttgc catggcaata attagcactg 1954741 taaatccgat gacgagccct tttatatgaa ataaagcaac gagtatcatg aggacaagac 1954801 ggctcatttt gtttgccaag cttaattcat aactaggcgt cgtaaaggtt ccaatcgccg 1954861 caagtgagac gtacagaatc acctcaggag aaaaaaggcc gacctcaatc gcaatctgcc 1954921 cgatcagaac agcggcaatt aaacccattg ctgtcgataa agccgtcggt gtgtgaatgg 1954981 cagccattct gagaaactcg attcctaagt cagctaaaaa tatctgcagg atgatcggga 1955041 tatgcgtatc tttatttaaa ccgataaatt tcatgttgtc cgggagcaga tcaggctgaa 1955101 gcacaaagag aaaccagatc ggaagaaata aagtagaagc aagaataccg aaaaatctta 1955161 cccgagctcg tggtcattcg gcataattac ttaaattttg tccagtctcc catcgtccgc 1955221 tttaagaatg tgataaaccc ggctttcttc atatcttctt ttgcagcaac aggactttca 1955281 gcgagtactt ctccatcctt tttcagaaca agagtgccaa gctcttggcc tttttgaatc 1955341 ggagcactaa tattgtcctt catcttgatt tcttttttca catcgttcat atcctcgcct 1955401 tttttcgtca atattgaaat cggctcagat gtagtgagtt cgataaattt ttgtttccct 1955461 tttttgacct ttacttttgc tactgtttga tttcgtttat ataaaggatg cgtttcatat 1955521 tggctaaagg cgaagtcaag catttttgtc acttgcgcgt ttctttcttt aggcgtgctc 1955581 gctccgaata caaccgctat ggcccgcatg tttccttttt tagccgaagc agtcagacaa 1955641 tatttcgctt cgcctgtata gcctgttttt acgccgtcta caccaggata aaatttgata 1955701 aggcgatttg tatttacaag ccaaaacttt ttatctgtat tttcacgcag ataatcttca 1955761 tacgtgccgg taaacttcgt aattgattcg tatttcaata attccttagc catgattgcc 1955821 atgtcataag cagagctgta gtgtccttcc tcggtcagtc ctgttgggtt tttaaaggat 1955881 gtatttttca atcccagctc ttttgctttt ttattcattt tcttcacaaa ttcttcttca 1955941 gagccggaaa taaattcagc catggcgacg gaagcgtcat ttcccgaagc gattgcgatg 1956001 cctttcagca tttctttgac agtcatttct tcgccgggct caaggaatat ctgtgagccg 1956061 cccattgacg ccgcatgctc gcttgtacgg accttatcac tcattttgat tttgccttta 1956121 tctaaagctt ccataatcaa aagcatcgtc ataattttcg tcatgcttgc aggcgccagt 1956181 ctctcattgc tgttcttgtt gtaaagcact tttcccgtgt cacgttctat cagcaccgca 1956241 gacttcgctt catgagcaag ctccgatgta cgttttccgt cttgttttgc aaatgcagac 1956301 ggtgcaaatg taagcagcat tataccaatc aacaaagtgg ataaaagacg tttcatctca 1956361 aaagccctcc atttcataat cctttttatt ttttccaagc gtgatggttt tatacgccac 1956421 tgatggaaaa tgtttcgaat tttgggcata aaaaaagaca gctgtgtgat atcagacaca 1956481 gctgtctttt ggtcctgcat tgattcatat ttattcgtac tgagcgacga tcgctttaac 1956541 aagctttaag aatccagctt ttactttttc ggtcacttcc ataacttcat cgtgacttaa 1956601 aggctgatcc agaattccgg ctgccgcgtt agagatgcag gaaatgccaa gaacccgcat 1956661 tcccgcatga ttcgctacaa tgacttccgg aacagtagac atgccgactg catcagagcc 1956721 catcgttctt aagaaacgga cttctgccgg tgtttcgtaa gaaggtcctg tcacagcagt 1956781 gtacacgcct ttttgaattg ggatattaag gtctttcgca atcttttcag ccaggctgga 1956841 cagatctttg tcataggctg aagacatatc tggaaatctg gcgccgaaat ctgcttcgtt 1956901 tggcccgatt aacgggtttg ttcccataaa gttgatatga tcggtaataa tcattaaatc 1956961 tcccgcacgg aattcagtgt tgacaccgcc tgcggcattt gtcacgatca acgcttccac 1957021 accgagcgct ttcatcacgc gtacagggaa tgtgactttc tccattgagt agccttcata 1957081 aaaatgaaag cggccctgca ttgcaatgac ggaaactcct tcaagagtgc caagcacaag 1957141 ctgtccggca tgcccttcaa cagtagatac cgggaattca ggtatatctt catatttcag 1957201 cttgaccgga ttttcgattt cgtccgccaa aatgccaaga cctgagccta aaataaggcc 1957261 gatctttgga gattccggca ggttttgttt aataaaagcg gctgcgcgtt caattctgtc 1957321 cttcaagaaa cagtccccct attgtaataa agataaaaag cttttcccgt atttcggttt 1957381 atttgtttgg aaattatcag cgatcgttgc gccaatatcg gcaaatgtat ctgcaagcgg 1957441 cagcatttgc gctttcttat gttttttgct gtaagcgaga atcggcacat actcgcgtgt 1957501 atggtcagtc ccatgatgaa tcggatcatt gccgtggtcg gctgtaataa ttaacagatc 1957561 gtcttctctc attttttcaa acacttccgg aagccgcgca tcaaattctt caagcgcgcg 1957621 tccgtagcct tcagggtcac ggcggtgtcc gaataacgcg tcaaaatcaa caaggttcgc 1957681 aaagctcaga cccgtaaaat cttctcccag cgtatcgatc accttgtcca ttccgtccat 1957741 attagaaacc gttctgcgtg aagaagtaat gccttctccg tcgtaaatat cagagatttt 1957801 accgattgaa atcacatcta agccgcagtc tttcaattca ttcatgacag tgcggtcaaa 1957861 cggcttcagc gcataatcat ggcggtttgg cgtccgtttg aattgacccg gctctccgac 1957921 gaacggccgt gcaataatgc ggccaaccat atatttcgga tcaagcgtca gctctctcgc 1957981 cgtttcgcaa atgcgataca gctcctcaag cggcacaacc tcttcgtgag cggcaatttg 1958041 cagaacagag tcagcagacg tgtaaacaat taaagcccct gtctccatgt gctcctggcc 1958101 aagctcatcc aaaatcgctg tgccggaagc cggcttgttt ccaataattt tgcggccaga 1958161 tctcttttcc agctcttgaa gcaattcatc aggaaagcct tccgggaaca ctttaaacgg 1958221 tttatcaatg tataaaccca taatctccca atggccggtc atcgtatctt tgccgtttga 1958281 cgcttcttgc atttttccat aataggcaag cggatgttct gttttttcta cacctttgat 1958341 atcttcgata agaccaaggc cgagctttgc catattcggc atatgtaatc cgttcatatg 1958401 ctcggcaata tgaccgagcg tatgagcgcc ttcgtcatta aagtcagcgg catccggcgc 1958461 ttcgccgatt ccgactgagt ccatcacaat taaaaacaca cgattatatt tgtatgcagg 1958521 catcttgaaa gcctcctttt tttctatacg tctattgtat cgctaagagg tctgacaact 1958581 caagtataaa ccgttttcat tcccgttgac aatgtatttg gaaataatga gaaacttcaa 1958641 tattttctgt cgctctaaac aaaaaagccg cagccacctg cggctatgct cgcggatgaa 1958701 actgcttgta cacatccttc agccttgttt tcgtcacatg cgtataaatt tgcgtcgtgg 1958761 atatatccgc atgaccgagc atttcctgca ccgctcttaa atctgccccg ttctcaagca 1958821 gatgcgtcgc aaaggaatgc ctgagtgtat gcggagtcag ctctttctta atgccggctt 1958881 ccaatgcgat ttttttcagg ttcttccaaa atccctggcg gctgatctgt ttgccgtgat 1958941 gatttaaaaa gagggcgtca gatacattat tttttaacag ttttcccctg gcttttgtca 1959001 tatattcctc aatggcggaa gcagcggctt caccgattgg cacaatccgt tcttttcttc 1959061 ctttgccgaa gcatcggata aaccccatag ataaatgaac atcagccgtt ttcaattcaa 1959121 tcatttcact gactcgtatg cctgtcgcat aaagcagctc cagcattgct ttatcccgat 1959181 atccgaaagg gctcgtcagc ttaggcgtgt ccaataaccg ctcgacttca ttgagcgcga 1959241 gcaccttcgg aagcgcccgt tccgtctttt gtgtttcgat atgaacggaa gggtccttat 1959301 ccgttacttt ttccctgagc agaaattgat gaaaagagcg aatggatgcc aaatgccgcg 1959361 ccgatgtctt gccggatttc cccgagtcct tcaaatgctt taagtattgg ataatatgta 1959421 tgcgggtaac gtgattccaa tctgtaacat gaagggtttc tgttaagtag agagaatagc 1959481 ttttcaagtc acgttcatag gatacgatcg tattttgaga gagccctctc tctaccataa 1959541 cgtagtggat gaaatccttt atttgatctt tcactcttga tctactcccc gttttggtaa 1959601 aaaaagatca accggtcgaa ccatccgcct ttttcatcct gatccatttc aacaactttt 1959661 acagcggagc cttccggttt atcataccga tgatagtttt catactcttg attcacccat 1959721 atcatagcat aatagaacaa agcggtaaaa ccggtaaaca ggatgaaaac tttcaatgca 1959781 tcgacagctg ttttcaggaa tcttcccatg tcctaatcga tcctttccct atggttccag 1959841 ttatataaac catatgccaa atcagaaagg ttttatacat agaaacagca aaaaaccctt 1959901 tccccatgag aaaaggttcg cgctcggcac cgtctattca gtttcttttc cgttacagcg 1959961 gtggcaaatg ccgtgaaacg tcaatctatg atctttaatc ttaaatttcc aatcacgttc 1960021 aatgatttct tccacgtctt caagcaaatc ttcttcaatt tcatcaacgg ctccgcactc 1960081 catgcacacc aagtggtgat gaaagtgagc tgcgccctct ttccgaaggt cgtaacggga 1960141 cacaccgtct ccaaagttaa ttttatctac gacttttaat tcagttaata attcaagcgt 1960201 acggtatact gtagcgagac cgatctcagg agatttctct tttacgagga ggtatacatc 1960261 ttctgcgctt aaatggtctt cttcgttttc aagcagcact cttactgtcg cttcacgctg 1960321 tggcgtaagt ttatagctgg atgagtgcag ttgtttctta atacgatcaa tacggttttc 1960381 catgtctttc cctcctacgc cgcattccat gactcattat aacaaaatac gcgcagagtt 1960441 ccaactataa ttattataaa ctgataaata aaatggtttt cttttaataa tgattttaaa 1960501 aaagtctaga tgtaagcttt tccattaaaa caggagataa gtatgcttca aagagagatg 1960561 aaatcagcgc taaaaacaga atgaccagca gcacaaaggc ataccgcccg aaccattgaa 1960621 tcggcgcgtc atgcaggctt cgtttcacga acagctgtct gattaacttt aaagaaaacg 1960681 caattgcaca tgtgcccata atgagataag ccggaatcag cagcacattt tgcggcaaaa 1960741 cggagacaaa tgataggaaa aacccgctta ctcccatctg attgactagg aacccgacag 1960801 taaagccgac gacgatccct ttcagaaaga tcataatgaa aataatcggc atcccaatga 1960861 cggaaattcc cagtatccac atcaggccta aatactttgc attatgaaag atactttgcc 1960921 caaacatatc agctgaactt gcctgttttc catccgaaag ctgtccaaaa aattgactta 1960981 agtagtagta taaatcttct ttctggctga tggtcatact gttgacaata atcgcgccaa 1961041 agatgacacc catgaaaaac agcactgaca caaatatata aagagagaga tgatctttga 1961101 catgcctgag aaacatgtcc ttataagaga tttttcgcat accgtttcct cccgcccgct 1961161 ctagtgattt gatttaatag attgtatgaa agaaacagaa aaacatgccc tttttcaaaa 1961221 agaaacaata gagatgaatg ctaggcggct ttttggggca caaaaaaatc cttatcatca 1961281 actgctgtat gatcataagg attcttatgc ttccgtttat tcaaaatctc ttttttgctt 1961341 tttgtcattc ttccatgtgt gctgaaagat ggtgtgctgc ctcttgataa taagacgtca 1961401 cgtccgccgt ttctcaatcg atgcccccgc ttctttttcg cttggctttt tgccatgtga 1961461 tcactccctt ttttattttc atagtaatga taacaaaatt gaacaatgat aagaaaaaaa 1961521 cagcacctgc tacgacaggt gctgtttagc tacatttatt tcactgctgt aagagctgca 1961581 tgctcgacag ctgctgctac cgcatgatgg acttttgaat caagcggctg agggacaaca 1961641 tcaccttgtt tagtgcaagc tgcgatggcc tctgctgctg cgacaagcat atcatgatta 1961701 atctccgtgc tttttgcgtt aagcgctcct ctaaaaatcc ctggaaaacc gagtacatta 1961761 ttaacagaac gcccgtcagc tgcatatgcg gcgccagcct gcagtgcggc ctccggctca 1961821 atttccggct tcggattcga taaagccaga atcacttgac cagaacgtac aaatgccggt 1961881 tttattaaac ccggaacgcc cgttgtagca atgacaatat cacatgtttc cataagctcc 1961941 tcaatactgg aaactgcctg tccgccgtat tgttcgagac ggttcattgc tgactctgat 1962001 ttgtctgttc cgtatacagc attcacacca taagccatga acatccggca gatggccacg 1962061 cctgctgcgc caaggccgat ttgccccact ttcgcttcct tcaggtcaac ccccgcactc 1962121 ctgcatgccg aaatggcagc tgccagcgtc actacagctg taccatgctg gtcatcgtgc 1962181 ataacaggga tgttcagctc ctcttttagg cgatcctcga tttcaaaaca atgcggcgaa 1962241 ccgatatcct caagaaggat gccgctaaag cccggagaaa tatgttttac tgttttgatg 1962301 atttcttcag gatcactcgt atcaagcagt atcggaatgc cgctaatacc cgccagctga 1962361 tcaaataaag cagcctttcc ttccatgaca ggcatgccag ccacagagcc gatattccca 1962421 aggcctaaaa ttgcggttcc atccgttaca attgcaacag aattgctgat cgttgtataa 1962481 atagaagctt tttcaggttc tttttcgatc agtcggcaca cgtccgcaac acctggtgtg 1962541 tagacacgtc ccagctctgc cagtgaacgg atcggcattt tgcttttcat ttggattttt 1962601 ccgccttcat gtgcggacag gacttcatca gatacggtgt gaagcctgat cccttctccg 1962661 agggcctgta cagccgcgat cacttcctga agctgttctt cattctccac ttgaacggta 1962721 atattccgca ttgtgtaatt gggtccgact tttaccgtct ccacttcacc aatatccccg 1962781 cccagaaggc cgatggccgt agccaccctt ccaagatttc cgggaaccga aggcgtttcg 1962841 atcatcagtg tccgaatcat gtgtttcgct atcattcagt gatcctcccc tattagccta 1962901 gtttttcggc tttaactgta ttgtttttcg tataccatat aaattttcct gtataaccat 1962961 agataattgc aagacctatt gctacaaaac tgagccacat aaacggcaga taagagaagg 1963021 tagaaacacc taaaatacca gccatgtaaa tcccattatc agaccaagga accatccccg 1963081 aagtcaatgt tcccccgacc tctgagttac gtgataacac tcttctgtcc agatgtaagc 1963141 gatcatagct gtcttccata attttcggag tcaaaataag agatacatac atcgcacagc 1963201 cgaagatgtt tgctaaaaac gctacgatca gtgtagacaa tgtgacattg ccggctgaag 1963261 ttaatttctt ttcaaacgtt gaaacaatga cttttaacac gccgagtttc tcaagcagac 1963321 cgccaaaacc aaggccaaag atgatgacga cgagagaatc aagcataccg acaattccac 1963381 cgcggtttaa caagccgttc aaaaattcaa catccgtttt aatagagaag ccgttgtacg 1963441 cagttgcaat cgcatgggca atatccattc cttggaaaac aacagcccag attgcaccga 1963501 gtaaagcgcc aattacgata actggcatag atggcttttt catcgccaat aagactatga 1963561 cgagaactgc cgggatcagc atccaaatat gaatgtcaaa cgtgttttgc aaagatgatt 1963621 ttaagaattc aactttatca agatcaatat ttttcccgcc gtacataaat ccaacaactg 1963681 taaagagtat agctgtaatg acataagcag gtattgataa ataaagcatt gctctcacgt 1963741 gagccaatac atcgactttt gatagtgaag aagctagaac tgtactgtca gacagcggag 1963801 acagcttgtc cccaaaataa gcacctgaaa gaatagctcc cgctactaga ggaagcggaa 1963861 tgcctaaccc ctctccaatt gcgatcatgg caatgccggc agttccgact gttccccatg 1963921 acgttcctgt tgccacagac ataatggaac aaataattaa cgttgccagt aaaaagatac 1963981 ttgggtgaat aaattccagt ccgtaataaa tcaaagtcgg cacaacgcct ccggcaatcc 1964041 atgttccgat gagcgcccca actgaaacga gaatcagtac ggcttcaagg ccatttgata 1964101 tcccatgtac aatcgcattt tgtaaatctt tataagaata accgagtcta atacctaaaa 1964161 gcattgcaat aaaccatgaa acaaaaagcg ccagctgtat cggcaagtcg agaaagactg 1964221 taaacgatag aacaagtgct aaaaatactc ctagtacaat aataatttca aatagtgttg 1964281 gcaatcttac atccttcaaa agaagtcccc cttcatgtaa aagctaaaac gctttcaata 1964341 tatagtgcaa cacgtatact atacttcctc atccctatgt tgtaaacagc ttattcatcc 1964401 gactattcgg agatgaataa gctgtatttt atacaaattt tatttttcta atagttcttt 1964461 ccctgcgata cctggtttgg tcatctcata tgggtttaaa ataatatcca attcttcttc 1964521 agtcagcaca tcatgctgca gacaaagatc ccggacagat tgccctgtca taattgcttc 1964581 cctggcaatt ctagctgccg cttcataccc aagatgcgga ttgacagctg tgatcacgcc 1964641 tgcgcttttt tctacgtatt gcttcatacg cttttcgttg gcttcaatgc cttttaagca 1964701 gttgtcagtg aacgaacgga agccgttgtt catgatgctg atggattgaa gcaaattaaa 1964761 gacaagcacg ggctccatga cgttcaactc aagctggccg gcttctgaag caaggcagat 1964821 tgtattgtca tttccgataa cctggaacgc aatttggttg atcagctccg ccataaccgg 1964881 attgactttc cccggcataa tagatgaacc cggctgacgt gcaggcagag aaatttccgc 1964941 aagtccggcg cgcggtcccg acgccattaa gcgcaggtcg tttgcgatct tcgacatgtt 1965001 catcatgcag acttttaatg aagctgatac ctctgtatag gcatctgtat tttgtgtcgc 1965061 atcaacaaga tgatcagcgc cgacaagagg aagcccgcta atatcagcaa ggtgctttac 1965121 tacctgtttg atatattcag gatcagcgtt cagccctgta ccaacagcag ttgcgcccat 1965181 gttgacttca tacaggtgct ggcgcgattg cttgattcgt ttgatatcac gctcgagaac 1965241 acggctgtaa gcttcgaatt cctggccaag acggatcgga accgcatctt gaaggtgtgt 1965301 ccggcccatt ttaataacag agtcaaactc ctgtgctttt tgcttaaaca cactatgcat 1965361 atcttccatt gttttcagca gtttttctaa gagcttcaat gtggaaatat ggatagcagt 1965421 cgggaacaca tcgttcgtag actgtgacat gttcacatgt gtgtttggac ttaaatggat 1965481 ataatctccc tttttatgtc ccatgatttc aagcgcccgg tttccgataa cctcattcgc 1965541 gttcatgttc atagaagttc cggcaccgcc ctgaatcgga tcgacgataa actgatcgtg 1965601 ccacttgcct tccagaatct cgtcagcggc ttgtacgata gcttggccaa ttccttcata 1965661 cagccgtttc acgtccatgt tggcaagagc cgcagctttt ttcacaatcg ccagtgcgtt 1965721 aatcatttcc tcatggattt tgtatcctgt gatcggaaaa ttttcagaag cacggagcgt 1965781 ctgaattccg taataaacat ctgcttcaat ttgtttttcc ccaaggaagt ctttttccac 1965841 gcgatattct ttttggccgt ttaacataat ctttaacctt ctttctcttt gctggttatc 1965901 gtttttacat tttacaggac aacgtcatca gctatcggcg tttccataat tctcttgacg 1965961 acaggaagat ccgaagactg acctagcgcc cacatcaatt ttggcacaat tgcttctgtg 1966021 ttcatatttc ttgatcggat aattaagtct tggttgactc tgcggccaac ctcgtaaatg 1966081 ctcatgtctt cgccttcttc aagacattga gtcgtaatga cgacgacaat gccgctttcg 1966141 atcagttcat tcacttttga caaaatgtct ctgccttcaa acggcactcc tccgctgcca 1966201 taactctcaa tgacaattcc tttgtacatg cttttcaggg catcaaacat ttcgggcttt 1966261 aagcctggat gcagcttcag cagacataca tctgtgcata gtgaagtgtc aactgtgaag 1966321 gtgtcgttct caggttccgt tacttgtttg ttgtattcga tcccgtcttc attgataaaa 1966381 gcgatatatg ggtaattgat gctttcaaat gcgtcgtagc ttttcgttct taatttgatc 1966441 gcacgcgttc cctgaatgac tctgccgtca aacacaacat aaacgccgcc cacgccttca 1966501 caggcaaatc gaatggcatc tgtaatattt tttttggcat cggttttttg gaacgtgatc 1966561 ggaatctgcg agccggtgat gacaatcggc tttttggcat gctgcagcat atacgatagt 1966621 gcggcagatg tataggccat tgtatctgta ccgtgagtaa taacaaaccc gtcataggca 1966681 tcataatttt ccttaacggc ttctgctatt tccacccagt attcaggctg catattggtg 1966741 ctgtctatat tcataagcga ctgagtttcc attgtgtaat cgttatcaag ttttgatacg 1966801 taacttaata attcatcagc cttgactccg ggagccagcc cattttcccc ttcaactgaa 1966861 gcaatcgttc ccccagttgt caacatcaat aattttttca taccatgcac ctcttcactg 1966921 tatctaaaga tgggttgcga gaaggtattc gcttttcgca tacttttaat gcaattatag 1966981 acacggaaaa taaaatacgc aagacattat tattcaattc gcgtacactt cctaatacct 1967041 atatgatata atcagctcaa ggtgaaaaag gagcggaagt tcatgaatct agatcgttta 1967101 actgaattga gaaaaaagaa aaattggtcg cttcaatata cagctgacct tctcggtatc 1967161 gcaaaaagca catatgccgg ctacgagtca ggctaccgac ggccttcact tgaagcgctt 1967221 gccatgctgg ctgacctctt tgacacaacc tgcgatgaac ttttaggccg cgagaaacaa 1967281 aagcagactg ctcctcaggc catagaattg gccacgtgga gcagcctcga ctttaccatt 1967341 tctgttgatg gccagccgct gagtgaagat gaaatcatcc agctgattac ctttatacgc 1967401 acaaaaagaa aagtacagga ggaactgagt taatctttag ctcacggttt aattttaccg 1967461 taggttcctc ctcctccggc tttcaattcc agttttccgg atctcgcttt tacgataagc 1967521 gccgcggttt tcggcgggac aacgcgagcc aaatcttctt ctgcagcctc atgaagaaca 1967581 gccatttctg ttccgaaggc tttttttagt ttgtccagcg ttttcgggcc tacacccgga 1967641 acaaattgca gcgggatctg atgtacatat cgcggacgcg ggacgcgaac ttcaagctga 1967701 tcactcaatt cacgcaatct atcgctgact cccttggtaa atctggcttt tccgcaattc 1967761 gcgcacgctg tttccccgct tacagcaggc tctccgcacg cttcgcaagc cgtctgataa 1967821 tatttcccca ataacgggtc caagccataa tttgcgataa ttttcctgtc atcttgtccc 1967881 tttaatgcaa gagcaaattc agtaaaatca gctgactgca catataattc attatattct 1967941 ctgccgattt tccccaacga atgcgcatca gaatttgtta aaaaaggata cggattcaat 1968001 tgcgatacgt gtgatgccat gtctgtatca cagcttaatc caagctccac cgcgtctatc 1968061 atagatggat caaaaacctc agttaagctt gatttaaccc cttttccata taagctttta 1968121 tgcggcgtaa agatatgggc ggggataaac aggccgccca tatcctgcac ttttttttgc 1968181 aggtttaagc ccgtttcata aatccgctgc gagcttaaat gaatattttt cagccgggct 1968241 gacagccagt ttgaaaactg tttcatatca gccagcgtcg gcataaatac gagcacatgg 1968301 atcggtccgc tgcaggcttc atcataaatc tccagctcgc tccccaataa aagagtcgtg 1968361 ctgcgataac ggattcctcc cccgtcaagc tcgcgatatt ttccagatga aatgccttcc 1968421 tcaagctcta gaatgacttc cggagaatga cagtcgataa tgccgaggag ttcaattcct 1968481 ttatgttcac tggcttcaac caaaattctg tccagcgtta atgttttggc gcctgttatt 1968541 ttgacagccc ttcctgtaaa ggtccggccg atatgaatgt gcaaatccgc gtaaatcttt 1968601 ttcatttttg tgcttggagc gcttctttca gctgaagata ctgaatcgcg taggctgttt 1968661 tagcatcata tacttcacgc gattcaacca gctttagcgc atcttcaagc gtcacctcca 1968721 tcacttcaac aaactcgtcc tcatcaagct cccgtttttc ttcaagcaca gaaagctcct 1968781 cagcaagaaa aacgtgaacg atttcatctg caaatccggg tgatgtataa aacgcagtta 1968841 tttttgtcag tttttttgct gtataaccgg tttcctcttc aagttcccga agtgccgtat 1968901 actccggctc ctcacctttt tcaagcttac cggccggaat ttcaacgatc gtccgctcaa 1968961 gcggcttacg gaattgtttg accatgatga ttttcccttc atctgtgacg gctagtaccg 1969021 ctacagctcc agggtgtttc acaatttcac gtttactggc tttgccgttt ggcagctcta 1969081 catcctcgac ataaagatca atgactttac ccgaaaaaat ctgttctttg gcaattgttt 1969141 tttcttctaa tgatttcatt tcttcatctc ccgttctgtc tctatatgat gccccataca 1969201 ttttatcata ctagagcaaa agggggcttc ttcgtgaaag tgcaccgcat gccaaaaggt 1969261 gttgtcttag tcggaaaagc atgggaaatt cgagcgaagt taaaagagta tggacgcaca 1969321 tttcaatatg tgaaagattg gatctcaaag ccataaaagt tgaaacttta gctcctttat 1969381 attacggtca atacaaagcc taaaaaagga gtgtgcacat gagaaagcgc aaattgggta 1969441 catctgattt agacattagc gaagtcggac tcggctgtat gtctcttgga actgaaaaaa 1969501 acaaagcatt gtccattctg gatgaagcga tcgagcttgg catcaactat ttggacacag 1969561 cggatttgta tgaccgggga cgcaatgaag aaattgtcgg tgatgcgatc caaaacagac 1969621 gccatgatat tattctggca acaaaagcgg gaaaccgttg ggatgacgga agcgagggct 1969681 ggtattggga cccttcaaaa gcttacataa aagaggcggt aaaaaagagc cttacacgtc 1969741 tgaaaacaga ttatatcgac ctttatcagc tccacggcgg cacgatagag gacaacattg 1969801 atgaaacgat tgaagcgttt gaggaattaa aacaagaagg tgtcatccgc tactacggca 1969861 tttcttccat ccgcccgaat gtgattaaag aatatgtaaa aaaatcaaac atcgtcagca 1969921 ttatgatgca attcagcctg tttgacagac gccctgagga atggctcccg cttttagagg 1969981 aacatcaaat cagcgtagtc gccagaggtc ctgttgccaa agggctctta actgaaaaac 1970041 cgcttgatca agcttcagaa agtatgaaac aaaacgggta cttgtcctat tcattcgagg 1970101 aactgacaaa tgcccgtaag gcaatggagg aagtggctcc cgatctttcc atgacagaaa 1970161 agtcgctgca gtatctgcta gcacagccgg ctgtcgcttc agtgattaca ggcgccagta 1970221 agattgagca gttacgggaa aatattcagg cagcaaatgc acggcgttta accgaagagg 1970281 aaatcaaagc gctccaatct catacgaaac aagacattta caaagctcat cgctcatagc 1970341 agaaaaacca gcacctgtac gggtgctggt ttatttatat tgatgccaat ccatttggct 1970401 ttcatttagg agttcttcaa agctcttatt tttttcgatc tcttttttct ttctaatctg 1970461 ttctgctttt tctcttttct gcctcttttc atcctcttcc ttcaattggc tcttcatctc 1970521 cataagcttt gctttgatat cggattgaag gccgtctttt agctggtgtt tgtcaatgga 1970581 tttttgtttt ttcatgcaga cttcccccat gttttgtttt gaagccagtt tatcacggag 1970641 catataaact gaacaagcag actctcttct gatcactttc tcagcgtagc agtgtttagg 1970701 tataatgatc ttaaacacga attgcctata tatttcgttg aaaggtgctg tgacttttga 1970761 agaaaatcct tttggccatt ggcgcgctcg taacagctgt catcgcaatc ggaattgttt 1970821 tttcacatat gattctattc atcaagaaaa aaacggatga agacattatc aaaagagaga 1970881 cagacaacgg acatgatgtg tttgaatcat ttgaacaaat ggagaaaacc gcttttgtga 1970941 taccctccgc ttacgggtac gacataaaag gataccatgt cgcaccgcat gacacaccaa 1971001 ataccatcat catctgccac ggggtgacga tgaatgtact gaattctctt aagtatatgc 1971061 atttatttct agatctcggc tggaatgtgc tcatttatga ccatcgccgg catggccaaa 1971121 gcggcggaaa gacgaccagc tacgggtttt acgaaaagga tgatctcaat aaggttgtca 1971181 gcttgctcaa aaacaaaaca aatcatcgcg gattgatcgg aattcatggt gagtcgatgg 1971241 gggccgtgac cgccctgctt tatgctggtg cacactgcag cgatggcgct gatttttata 1971301 ttgccgattg tccgttcgca tgttttgatg aacagcttgc ctatcggctg agagcggaat 1971361 acaggctccc gtcttggccc ctgcttccta tcgccgactt ctttttgaag ctgaggggag 1971421 gctatcgcgc acgtgaagta tctccgcttg ctgtcattga taaaattgaa aagccggtcc 1971481 tctttattca cagtaaggat gatgactaca ttcctgtttc ttcaaccgag cggctttatg 1971541 aaaagaaacg cggtccgaaa gcgctgtaca ttgccgagaa cggtgaacac gccatgtcat 1971601 ataccaaaaa tcggcatacg taccgaaaaa cagtgcagga gtttttagac aacatgaatg 1971661 attcaacaga ataaaaaagc gaaaggcctc ttcggctctt tcgctttttt atgttacaga 1971721 acgtcggtaa tgccatccat attttctctg atccattcaa tcgcaagatc tatcgttgta 1971781 aactcctgcg tctcgaaggt catttcatcc tgcaatagcc agacatcttt cttgatggac 1971841 tctgctcctc cgattgacca gtgaagcaag gtataaggat ggttttgatt caggaaggat 1971901 acccacgttt tattttgtgc tgtgttcttc attgccttca gcttttgttc cacgtttcgc 1971961 gtctcctact ttactaatat gctcattctg gggctgagca tttcagccgg gcttttcagc 1972021 gccaatgttt tggctttttc attgtaatcg atcgtcattt gatcgtcaaa aaacactttt 1972081 tgcgacgatt ggatatacag cggaatgccg ttcgtttcca gctgctcgca ctgtcccgtt 1972141 aattcttctg ccagccagat tgtcgggaca ccgcttaccg cgcagccgca tccttctgca 1972201 tcgtaacgaa gctgggcttt ttttcccggg ttggcgtcaa acgcctgctg cagtgcctgt 1972261 tttgctgcat ctgtcacatg tatgttcata aggtgaaacc cccgttttca tcattttcgc 1972321 tattgtagca tacaatactg ccattcgcat tgtttctgcc ttttttccac cgcttcgcat 1972381 tttcttctgc agtcttgatc cactcatctt tcccttgtat atactgattg atgctgtcag 1972441 ggtgctgggc cgccagctgt tttttgagaa cggcgtattc tttcgctatg tttggatgag 1972501 ctctgagata atctctgaat aacagatgcc tttcaatagc agggtttccc tgttcgtaca 1972561 tatggacatg atgagtgcgt ttatttccgc ccttttggaa ataacgcctg cccgctatac 1972621 cgttctcacc ttttggtgta tagccgttgg ccttcatttg ttcatcaaat tggctcacgg 1972681 cttcaatgct tctgacttca attaacatat caatgattgg cttcgctgcc atgttaggta 1972741 ttgatgtgct tccgatgtga tgaatagcga taatctccgg cccgaacaca agtttcagcc 1972801 gttctttttc ttcatcgaaa cattctgccc atttttcgtt gtagagaatg atctcaactt 1972861 ttcttttcgg atacaaatga aagaccgaca gcaatagacc ctgcgctgct ttgacggttt 1972921 ctgccttttg gaatccggcc tgtgtataga gtgacacagc cggggtattg ttctcggctg 1972981 tgactacttc gattttctca gcgtcttcat tatgatcaat gacaaattgc agaagcgctc 1973041 gtccaattcc ttttctgaaa ccgtcaggat gcacaacaag cctgcaaatg gtgagataat 1973101 gcatgttttt ctcatatgaa atgacaccga tcagcttgcc gtttttccga tatcccgcaa 1973161 accgttcatg ggatgcttga atatccttta ccttctcttg taaagcggga ataccgtcaa 1973221 aaccgataat ctctgtttcc tttatgtagg cggggatctg tacggctaaa atctcacgcg 1973281 ctatagtggc ttccttatgc tggagaaatt caatcattcg tgttctcctg aaacagccgc 1973341 tgtctgtcga cttttgcgac gcggactgca tacgactcgt accaaacgct tcttcctttt 1973401 tcttttgctg cttgatgttc agtgtgatgc ctccaatggt taattgcgtc catactgtcc 1973461 caataggaaa ctgtgatgcc ccttccatcc gcttcacgta cgctttccac gcctaaaaat 1973521 ccaggctgat ccgccgcaag tgataccatc cgctccgctg tttctccata tcctgtgtca 1973581 ttttcgcttt tgacagaaga aaaaatgact gcatagtaag gaggctcagg tgtttttgat 1973641 aaaaaatcca tcatatttcc ccctcatatg tttttgacaa atagtaccct gtcttggccc 1973701 gggccatcat agtttgcaaa cactgagatg ccatttaccg ttttggtgcc cttttcaata 1973761 tcaaacccca attttgtgtg atatgcgatt gataccttat tcacaggtga agtgacacac 1973821 ttcacccggg tgcagcccct ttgttttact gtttcgataa atacatcata caattgtttc 1973881 ccaatttgca tttttctgaa atccggatgc acaccggaaa aatgaatgta cgccgtttca 1973941 ggatcggatt gcgattgaaa tccgattaaa aatcccgtca tgctgttatg ttcggatgta 1974001 ataaagcttg tgtcctgaaa atgctcaaaa aatagtctcg gcaatttttc tttcagctgt 1974061 ctgccgcccc accattcatt cagtacagac gttaccattt cataatctga agacgtgatt 1974121 gttcgaatat ccattacgat ttgatctccc tccgtctggc aaaacgaatg tcagctcttt 1974181 ttctcacaat ataaaaatta tattttgcct ggctggaatt gtaaatgcct tctttcctgt 1974241 atcatacgtt tccagactgc cgagggaaca atgtttgatc attttacgcc tatttctccc 1974301 ccaaacagga ggagagactt tacagcacaa tatcaagcac ttgatcaagt ttcagcttat 1974361 aaagctgatc ctcgtctcct tttatccata ctgctttttc aaactcttca taccggcaga 1974421 ttttcccggt gcagcagaca atctcaccgt cctgaaagca gctgacagtg atatcctgag 1974481 caaactccat cgcggcgcaa agcgtttgat tcatctcttc cagcttatcg gggtcaagga 1974541 tcggcttttg cagcttctgt ttaagtcgct ttctctccag caggctttgc ttatgttccg 1974601 gcagaaacat cctgctccct tcccacagca ggttgcccct ttttaaatgg tcgttcattt 1974661 ataatgcccc cctattttag ccgcacgttc aaatgcctgg cctgccgctg tcagtgacgc 1974721 cgccctgatg attgctgtat cgccgaatcg atttttaatg ccatccatca catagcctag 1974781 gctcattttc tttgcataat cctgaaataa attgagctgc catatgtcat cagatgagag 1974841 ctgagacaga ttgacaccga ggcggcggac gggtttcccg tcccaaaatg taagaaacag 1974901 ccgtcgtaca gcctcatata catcctgcgt agaattagtc ggctctgcca gcttcacttg 1974961 ccggttgaag cccgtcggcc aatcaaaatc agcaccccgg cagctcactg acactgtctg 1975021 ccccatgacc ccggcgtttc ggcttcgcct gcacacctct tcactcagct caagcaatac 1975081 gaccttgatt tctttgtcaa agtgttcgta gtctctcggg agagtcattc catgacctat 1975141 cgccttttgc ccgtccagag acgaagttga cacaggggaa tagtcgattc cgtttgccgt 1975201 catccacagc acgtggccgt taatgcccca tttctttttt aaaagatcga gcggaaaagc 1975261 cgcgagcccg ccgatcgtgc tgatgcccat tcgatttaaa tgatgcttca tgcggctccc 1975321 gacgccaaac atgctgccca ccgggagcgg ccacatttcg gttttcatat tttctttcgt 1975381 taaggtaaaa ataccgttct tattcttttt ggcaaaattg tcacacgcaa ttttggccag 1975441 cgctttgtta gggccgattc cgacccgtgc ataaacgccg atctcccgca tgattctgcc 1975501 ctgaatgctt ttcgcgatct ccatcggcgt cccaaacagc ttctggctgc ctgtaatgtc 1975561 catgaactgt tcatcgatgg aatacggctc cacaaggtct gtatactcct cgagaatggc 1975621 cgtaatttgc agtgatacat caatataccg ctgcatacgc ggccggagca caacagcctc 1975681 aggacacttt tcctgcgcct cccacagccg tgaagcattc accacaccct tttgtttcgc 1975741 cagcgggcag gcagccaata cgactccgcc ccttttttca gggtcacccg aaacaatgac 1975801 gggcctattt ttcaaatgtg gattttccgc tttctctaca gatgcataaa acgattgcat 1975861 gtcaacgaga aaaatcactt tttctttcat catacacacc tctaaaaaga acttatgttc 1975921 gcttttcatt atatgcgaaa gtatgttcgt tttatactgg taaatgattc ttgtctgaca 1975981 gaaaatatga tccaagggtt tgagagaaga aaaacattta gtagaataaa agcgaagcat 1976041 aaggatagga gagtcatgat ggagaaattt gtcgaaaaaa tgctgggaca ggcattgcgg 1976101 caatacggca gaaacgttgc tatagatccg ttaagcccgt atgaaaaaca aagcctgaaa 1976161 gcggctctac aagagagacg gaatgaagaa ccagatgagg atttgcatgc gcatatagaa 1976221 gatatcattt atgactatgt cacaaaccaa ggcctgttct cttaaacgca tgactgtcag 1976281 ttctttcagc cgctgatgcg gcttcccttt gaaaacaccg cctgaaacaa ataaacagtc 1976341 tcaggcttac agaaaaaaag caggattttc tcacgctcca tagattcata tggcctggcg 1976401 taaaattccc ctcaatgctc gcgcaaaacg gaataagctg tccatgatca cgcgtataca 1976461 ctttttcgaa gagatgtgct ctcttgttct gtcatgcggt ccatgccggt tttcagcgta 1976521 catcttgatc tcatagccgg tttcactgcc gatatgatcc acgttctggc ggcttaaact 1976581 aacacaccct cactgaccaa tcgctttgct tttcatcgga catcccgtca ttttccttct 1976641 ttcaagatgt aaactccgtc agccacacgc atcctcaacg catagtatat tgccatccat 1976701 acaatcaggc atactacatg tcaataacga aatattttga acgatctatt ggagaaggaa 1976761 attttttcat atatgataga gaaagatcat acatacagga gagaatataa ttcatgaaga 1976821 aatggaaaga tatccacccg atcagctgga caattataat cggaaccatt ttcggcagaa 1976881 tggcaacatc gatgagcatt ccttttttag cgatttattt gacagccgtc caaggcgcat 1976941 cagcttccta tgcagggctg gtcatcgccg cgagctcatc agtcggcatc ctcgcaagct 1977001 tttacggcgg atatatctca gataaattcg gcagaaaaaa catgatgctt gtatcgattt 1977061 tcggatggat gctggtattt gcaggctttg cggcagcatc taatctctgg gtgttttttg 1977121 tagtaaacgc attaaacggt ctttgcaaat cactgtttga gcccgcttca aaggccttgt 1977181 tgtctgatat gacagaagaa aaaacgagac tgctagtttt taatttacgc tatgcggcta 1977241 ttaatatcgg cgttgtcttc ggacctgtgc ttggcctata tttcggctca tcgcaatcga 1977301 ctacgccctt tttggtgcct gcagtcattt acggactata cggaattgtg cttgccctcc 1977361 aatttaaaaa acatccatcc ttatcagcac cagcccagtc ccgaaatatg agcgtgcggg 1977421 aagcgtttat ggtcacgcaa aaggattatc tttttaccat tgctttggtc ggcattacgc 1977481 tatgcacctt cggctactca caattcagtt ccacattccc tcagtatatg gcgcagaacc 1977541 ccttgatcgg caatggaacg aagctgtatg ggctgatgct gacattaaac gcaatcgttg 1977601 tgttggcgac gcaatttccc attgtccatt ttgcaaaacg gttttcgccg ctttgttctc 1977661 tgatgctcgg taatgtgatg gttagcatca gcatggccat tttcaccgta tcacacggtg 1977721 ttccatcaat tgtgatgatt gtcatcacat ttacaatcgg cgaagtgctt ttattctcta 1977781 tgatggattt gtatgtagac cagattgcaa aaccaggatt aaaaggcact tatttcgggg 1977841 caatcggttt ttcacagctc ggaaacgtca tcggcccttg ggtcgggggg atatgtatag 1977901 acctgtttgg cgctggccgg ccgatttata ttttttctgt cctgagcggc attaccctgc 1977961 tcggcctgcc atttttagcg ttcgcctatc ggcaaatgaa aatggagacc acaaaacacc 1978021 gttcccgtct ggaaaagccg ctttaaataa aaaacggaag agaatgaatc tctcccgcaa 1978081 acatgaggtg aagaacatga atataggtga tgtgatgttt cagctgtttg tatttattat 1978141 atttgccgct gtcgtctttg cggctgttac aggcttcaag tatgcgaaaa accgaaaagc 1978201 gcagctggat cgcattgaga aaaagctgaa cagcctgtcc gaagatcacg attaacagct 1978261 tggggcaacg agctctacct taatccggtc tggatcctca caaaagactg cataatgccc 1978321 gtctcctccg gcaaaaggat gcctgtctcg gtacaacaca cgatagcctt ttgccgtcaa 1978381 tttttcagtc atctgatcga cttgaagctt ggattcagca tgaaatgcga gatggttcag 1978441 accgactcgg catctatggt attccggctc tagaaatggc tctttcgcct gcacaatcac 1978501 taggtaaaaa cgatctttct tccagctgat gcctgagctc catttttgat actctttata 1978561 accaagttct tttaagaacc agccccaaaa ccgcctagac gcctccaaat cagagacata 1978621 cagttcaata tgatgcacat ttcataccct ccttaccaac acttcctcga ccttatgccc 1978681 gtctccctta cgcaaaatga gatctgacct gaatttagtt ggcaaaatat tttcatataa 1978741 attcggccgg ttgacactct cccaaatcga ggctgccatc tcgtcagcct cctgatcgga 1978801 caagtcttta aatttatgaa aatatgaatc aggattttga aaagctgttt cccgaagcag 1978861 gcgaaaacgc tctaaatacc aagtgaaaat ccggctttcc tccgcatcca cataaatcga 1978921 aaaatcaaag aaatcggaaa caaaaatacg cgggttttcc cggtcatcct ccaaggtggg 1978981 cgactgaaga acattaatgc cttcaataat cacaatatcc gcctgttcta caacctcgaa 1979041 cacaccttcc tcgcggtcat aggttagatg ggaatacacc ggggccttta cgctgtcctt 1979101 tcctgatttt aagtcattca aaaattcgag cagcgccttt acatcatagc tttcaggaaa 1979161 tccttttctt gacatcatat ttttcttttt cagctcggca gtaggaaata aaaaaccatc 1979221 tgtcgtgata aggctcactt ttggacggtc aggcaaacgc gaaagcagct tctgcaagat 1979281 ccgcgccgtc gtgctttttc cgactgcgac actgccggca atgccgataa taaacggaat 1979341 tttggctgaa tgtgggtgct tcaaaaaaac attgacatgc ttattgcgtt cagccgcaga 1979401 cttgacatgt aaatgaagca agcgaacaag cggaatatag atcgtctcca cttcttcaac 1979461 agatagataa tcattcaatc cttccacagc ttttgcctct tcttcagata cagcaatcga 1979521 caaatgcccc ccaaaaccag accaagactc ccgattgtgc tgtgtatata aagtatgtag 1979581 gttaagttct ttatttttca ctgtttacac ctgactctct gtaggttaaa acccttacaa 1979641 agattgtaac ggaaaacctt ttcactgtct gcttattttt catttcgttt ttttagcaaa 1979701 tcagcaccga ttcggttata cgcagccatt tcatcttttg gaaccatgct tcctcccgtt 1979761 ccccagacga catgtacggc atgttccatc ttatatttct gagcatagcg ccttccctct 1979821 tctgtcgaaa aaagctgaac cggcccgaac atgccagcaa gagcagaggg ctctaaatat 1979881 ttatcttcag atacagccag catatgaagc aaagtataaa gcgtattgtc ctctaccgta 1979941 taacagccgc tcagaagcgg ttcaatcagc ttgccgacaa atcctgacgg cctccctacg 1980001 gcaagtccgt cagcagccgt ctgattatcc aggccgatat cctggacgga gatcttctcg 1980061 tgaagtcctg aataaagccc taacagcata caaggtgaat gagttggttc tgcgaaaaac 1980121 acatgaacat catctccgta taaaagcttc agcccaaatg ctacaccgcc cggtcctccg 1980181 ccgactccgc acggcagata cacaaacaag ggcgtctcaa gacttggctt tatattcata 1980241 cagtcaagct gtgtttttaa tcggcttgca gcaacagcat atcctaagaa cagctgacga 1980301 gaatgttcat catcaataaa ataacagaat ggatcttgtt ccgcctgccg tctcccttcg 1980361 ttcaccgctt cactgtaatc tgtttcgtac tccataacag tgactccctt ttggcggagg 1980421 agatcctttt tccactgctt agcatcggcg gacatatgca ctgtcacgcg aaacccgagt 1980481 gccgcgccga tgatgccgat gcttaaacct agatttcctg tcgaaccgac agcaatcgaa 1980541 tagcgggaga aaaacccggt aaaccgctct tcctgtaaga tgcggtaatc atcggtttcc 1980601 tgaagcattc cttcttgaag cgcgagattt tcagcatact ttaacacttc ataaatcccg 1980661 cccctcgctt taatcgatcc tgaaatcgga agctcatggt cgcactttaa aagccatctt 1980721 ccgggaaatg gctgctgata tgccgcttcc agctttccct tcatatgctg cacctcaaaa 1980781 agcggagact cgatgattcc tttagcgcct ttcgtctcag gaaacacctc ggcaatgtaa 1980841 ggtgcaaacc gctgcattct tttttccgct tccgctatct cggttgccca ctcatctgca 1980901 cggggtaatg gcccctcttt cttgcctgaa tttgcccaga atacaggctc tgcatcaatc 1980961 agtttctgaa taaacggatc tttaagcaga gcatgaagga cttctgaatg aactgacatt 1981021 caacaatctc tcccttccac tatcaaaaac tgccccgtga gaaacaagcc actccaccac 1981081 aggcagttct atcattattt tttcatgagc gcgcgtcctg ccagcttttc tacaagagct 1981141 ggaaacagct gatacagctt agtgccggca ttcattaaac gcggaagatt gatctcccgc 1981201 tttttcgtaa aaattgcagc tgtaatttga gctgccacgt catcaggatc aagcatccag 1981261 cggccgacat ttttggcgta gtccccgcct ttatcagcaa tggaaaaaaa gtccgtctga 1981321 atcgggcccg ggttgactgt tgtcacataa atgccggttc ccgaaagctc catccgcaaa 1981381 gcgtttgagt aacctaacac ggcatgtttg gtcgcggaat acaggctaga cttcggtgtg 1981441 gcgattttcc ccgcttgaga ggcgatattg atgatatgtc cctttttttg ctcaagcatt 1981501 tgcggaagca ccgcttttgt acaggcgatc aggccgaaga cattcacatc aaacatcgct 1981561 ttcatgtcat ccaatgtaga gtctaaaacc gtttcaaata taccgaagcc tgcattgtta 1981621 atcagtacat caatcgagcc gatctgatcg cggacccggg cgatatcctc taggcggccg 1981681 acatccagag gaaaaatctc acactgtccg ctccattcct cggttatttt ccttttgatt 1981741 tctatcaaac gatcctcgcg tctagccgac agcaggacat gggctccttc agccgcgcat 1981801 aagtatgcga ttctttctcc aagccctcct gaagcgccgg ttatccaaat cctttttccc 1981861 gctatatgtt tcacccattt cacctcttca ttgttttaaa gtatacggta tttccttccc 1981921 aatatgacgt gatggcttct tcagcctcca acacatcaag gtgacctgcc gtttctgaca 1981981 tcgttaaaaa caattccttt tcatatacag caggaaaaag ctgctgacag acctgaaaag 1982041 cggtcatcgg cttttcatcc agcatgcgac gcacatcctc cgtcctgttc ctctgcttgt 1982101 caaaacgctt ctcaatcagc gcttgtacac tggtgatagg ctcgccgtga ccaggaaata 1982161 cgattgttgg atcaagttga gacagccttc gcaatgaccg ctgataatcc actaaaggct 1982221 ttgacctgac gtctcccgct ttcggcgctt ccaaaatcgg attagacgag ctgtttgcca 1982281 gcagtagatc gccgccaagc atccttccgc ttttttcatg gaacagaaca atatgcgatt 1982341 cagcatgtcc aggcatctcc aacacagacc agccctcaag cccatctatg cccatacctt 1982401 ctctgattga ttttgtcaga gatctcgtac aggaaaatgc gtacgctgat cgaatcagct 1982461 tttccgcctt ccccgtatca aatggaacgc ctaattcagg cagcagcttt tgaaaaaaac 1982521 gtttttgcca atccataaag gcttgatttt ggctgatata aggttcgttg aatgtatgcc 1982581 caatcacttc gatttcatct gaaaagacat caagcaagcc tgcatgatca gcatgatggt 1982641 gagtcagtac aacctgctcg atatctgaca atttcacatt tacagcggca agctgctctt 1982701 gtaaggctct ggcagcctct tttgtattcg gcccggcatc gataagtgtc agcgcatcac 1982761 cttttacgag gtaaacgata acatcgccga cagcaaacgg tgtcgggacg cggatcgcaa 1982821 ttacatcttc agttgtcatc ctttcgctcc ttgtcttcat tcattattca tattttagct 1982881 ttttctcggt cttgtgtcat tattgcagaa tgagaacaaa cctttttgaa aaagctattg 1982941 acattagctt gtccgccatt gcataatgaa caacaaacta aaacgagaac cattggaacg 1983001 ctatgacgag gaatagtata caaggcaatg gcctaagaga gcgatacccc cggctgaaag 1983061 gtgttgcggc ccgcttgttt gtagaacctg ccctcaagtc gcggttagga aaacctaaac 1983121 gtttcccgcg ttacggggat ttgagctgag cacaatttgt gctaatgagg gtggtaccgc 1983181 gaaccttttc gtcctttacg tgatgaaaag gttttttgtt gttctaatag aaggaggata 1983241 tcaatgaaaa agataggatt tgtcggcgcc gggtcaatgg cagaagcaat gatcaacggc 1983301 attttgcaaa gcggcatcac aaaaccagaa catatctata ttacaaatcg ctcaaatgac 1983361 gagcgtctga ttgaattaaa ggaaacgtac agcgtgcgtc catgcagaga taaaaatgag 1983421 tttttcactc acaccgatat cattatcctc gctttcaaac cgaaagacgc ggcggaaagc 1983481 atcgacagca tccggccgta tatcaaggac cagcttgtca tttcagtact tgcaggcctt 1983541 accatcgaaa ccattcagca ttattttggc agaaagctcg cggtcattcg cgtcatgcct 1983601 aatacatcag cggcaatcag aaaatcagca accggatttt ccgtaagcac ggaagcaagc 1983661 aagaatgata ttattgccgc aaaagctcta ttggaaacaa tcggtgatgc aacactggtt 1983721 gaggagcggc atcttgacgc tgtcactgca atcgcaggca gcggcccggc ctatgtgtat 1983781 cgttatattg aggcgatgga aaaagcagca caaaaagtag gattagataa agaaacggca 1983841 aaagcactca ttttgcagac aatggcaggg gcaacagata tgctcctcca aagcggcaaa 1983901 cagccggaaa agctgcgtaa agaaatcacc agtcctgggg gcactacaga ggcaggtctt 1983961 cgcgctttac aggactcccg ctttgaagaa gcaattattc actgtattga agaaacagct 1984021 aaacggagcg cagaaatcaa agaacagttt gccggtgccg ccttagagag acattcttag 1984081 atgtaaggac aaaaacagaa ggcacagtgc cttctgtttt ttatttttcc cgcagcagct 1984141 ggccggcaga ttctgattgc tttaatagcg cggagatcgt aaatgaaagc aaatcgggaa 1984201 gcacttcaaa ggaataaggc atatacaatc tttccgtcca tttatgcggg tctttaccag 1984261 ccggaccgac atttaaaact gggacatata aagcctgatt tttaccgctt ggcaatgaat 1984321 accctctgtt aaagagcggc atattgcttg tgtatgcatc aacctcctgt ttttccagct 1984381 gaagataact caagtccgaa agtccgggga agtactgaac ctcccgtaat gcaatgccgt 1984441 atcgctcagc cgcataatgc tttatctgat ctgctgtatt tctgatcaat tgatcatcct 1984501 ttgaagaaac agctggataa agcggcggac tataaaacag aacgatgagc ggcgcatcct 1984561 ccttacaaag cgaagcaagc tcagaaacaa ttttcgtcga aaaatccctg tctccaagct 1984621 cccccctgtt agcaaaggca taatttagag cccgctctgt ttccgagatc cccgcacgct 1984681 tttttgcacg cgagaccagc tcatcaaatg tcaaaacagt gacgtcccgc tcaatcggct 1984741 gaaatggctc aaattgttga aaatcctgtg ttttcttccg aacgttcgac atgatttcct 1984801 ccgccgcctg ttctgctgtt ttaagcagca tctgatgcag ctcactagct gagcgtttca 1984861 ttgacagcac attaaataat gtgacggctg tatgcggtgt ctggactgaa tatgcctctt 1984921 tcaagtcctt ttgcattaag tttaccggcg gcggagtgac ctcgccatca accttttcgc 1984981 aataatcagc attcagttca agcaaacggt taatctcaga taccattaaa tttgcgttta 1985041 gacctgaaaa cggctctcca acatgtgtct caatcccctt gcagaaaaaa cccgcaagca 1985101 ccttgccaat gcttcctgta taaaaatatt gctgctgatc gccgggaaat ttttcaaaca 1985161 tcggttcggc attcaggcaa gcggttaatg tgatatcatg ctttttctcc atctccttca 1985221 atgcaggaac cgcttcaatc atgcctcttg aattcacttc ctcgtccgga accgttatca 1985281 acagcagatt gccctcaaaa tgcccgttca ttgccctctc cagcatcgac agttgaatac 1985341 aaagccccgc tttcatatcc atcgtccctc ttccgaacag ccagtctccg ctttcggcat 1985401 ctcttctcac acgttccggg agcagctctt ttttctctaa aaaggagctc aaaagctcag 1985461 caggcttgca agccatatgt ttaaattcgc cgtaatcttc tatgtcaacg acatcaaaat 1985521 gactcagcag aagcactgtc tttttgacat tcttcttttt gactagagcc gtaagaaaag 1985581 atctgccatc gtccatcgga tgaagtgtta catcatcagg gtgcttttga aaatagggct 1985641 tgtccttcaa aataaaataa agatactctg caagcgctac ctcgcccttt gaaccggtga 1985701 tgctttcgta ttgcacaaga gaagttaaaa gtgccagcaa ttcgtccttc gtctgccaat 1985761 tcattgattc cgcccctcct atgaataaaa atgcttctat actgaaaaat aaactgattt 1985821 ctcgtctatt atacagaaat gtttgacaaa agcggttcat ttgagcagtt tatatgacgg 1985881 gaaagaaatg acttgatata atcaatctct aaaaacctta cgggaggcga aagaaatggc 1985941 cagaaaatta tttacaccta ttacaattaa agatatgacg ttaaaaaacc gcattgtcat 1986001 gtcgccaatg tgcatgtatt cttctcatga aaaggacgga aaattaacac cgttccacat 1986061 ggcacattac atatcgcgcg caatcggcca ggtcggactg attattgtag aggcgtcagc 1986121 ggttaaccct caaggacgaa tcactgacca agacttaggc atttggagcg acgagcatat 1986181 tgaaggcttt gcaaaactga ctgagcaggt caaagaacaa ggttcaaaaa tcggcattca 1986241 gcttgcccat gccggacgta aagctgagct tgaaggagat atcttcgctc catcggcgat 1986301 tgcgtttgac gaacaatcag caacacctgt agaaatgtca gcagaaaaag taaaagaaac 1986361 ggtccaggag ttcaagcaag cggctgcccg cgcaaaagaa gccggctttg atgtgattga 1986421 aattcatgcg gcgcacggat atttaattca tgaatttttg tctccgcttt ccaaccatcg 1986481 aacagatgaa tatggcggct cacctgaaaa ccgctatcgt ttcttgagag agatcattga 1986541 tgaagtcaaa caagtatggg acggtccttt atttgtccgt gtatctgctt ctgactacac 1986601 tgataaaggc ttagacattg ccgatcacat cggttttgca aaatggatga aggagcaggg 1986661 tgttgactta attgactgca gctcaggcgc ccttgttcac gcagacatta acgtattccc 1986721 tggctatcag gtcagcttcg ctgagaaaat ccgtgaacag gcggacatgg ctactggtgc 1986781 cgtcggcatg attacagacg gttcaatggc tgaagaaatt ctgcaaaacg gacgtgccga 1986841 cctcatcttt atcggcagag agcttttgcg ggatccattt tttgcaagaa ctgctgcgaa 1986901 acagctcaat acagagattc cggcccctgt tcaatacgaa agaggctggt aatgcccata 1986961 agagatatcc tgtagaggat atctcttttt ttatttttag agaaacgatc ggctaaggtt 1987021 ctccgtctcc ctagtagaac caattagagg agatgactcc aatgaaatca gcttggatgg 1987081 aaaagacata tacaattgac ggatgtgcgt ttcatacaca gcaccggaaa ggatcaagcg 1987141 gtgtaacgat tgtctttgag gccggctatg gtacttcttc tgagacgtgg aaaccattaa 1987201 tggcggacat tgatgatgaa tttggcattt tcacatatga tcgggcaggc ataggaaaaa 1987261 gcgggcaaag cagagctaaa cgaacagctg atcaacaagt gaaagaattg gagagtttgc 1987321 ttaaagcagc tgatgtaaaa cctccttatt tggctgtttc acactcatac ggagctgtca 1987381 tcaccggttt atgggcctgc aaaaacaagc atgatattat cggcatggtc cttcttgacc 1987441 cagctttagg cgattgcgcc agctttacct ttatacccga agaaatgcac aaatcacata 1987501 cgagaaagat gatgcttgag ggcacacatg cagagttttc aaaaagtctg caggagctca 1987561 aaaagcggca agtccactta ggaaacatgc ctcttcttgt gttgtcatca ggagaacgga 1987621 ctgagaaatt cgctgctgaa caggagtggc aaaacttgca cagcagcata ttgtctctat 1987681 ctaaccaaag cggctggatt caagctaaaa acagctccca caacatccat catgatgaac 1987741 ctcatatcgt tcacttggct atttatgacg tatggtgcgc agcgtgccag caggccgctc 1987801 ctctttacca ggcagtcaat taacgtaaaa aaagaccggg ccgtaaggga ttcccggtct 1987861 tttatattat tttgtttcac ggtgaagggt atatttcttt aaacgcggtg aatatttttt 1987921 cagctccaaa cggtctggat tggtgcgttt attttttgtt gtgatgtaat ttcggtctcc 1987981 cgtttcagtg caaagctaaa gtaacattta ctctcataat taacatctcc ttataaaacg 1988041 taatgattac gttttattat acaacgtcat cacaaattgt caaataagag ctccgccttc 1988101 agcctcgcgg gacgtttacc tctaagaaat catatgccgc cacgctattg gggaaaacgt 1988161 caaccgcttc tttttgaagc tccaaagaag catctccctg atatcttgcg ctgatatggg 1988221 ttaaaatgag ctgcttcgct cttgcttctt tcgctgttac agccgcttgt tccgttgtac 1988281 tgtgataata atcataagca agtttacggt cttccttagc aaaggttgct tcatgaacaa 1988341 gcacatcaca atccctcgca agctctttta gtttgtcact tactctcgta tcaccggaga 1988401 acacaacaga tcttcccttt ttaggaggct ccagaaaatc attcccattg atgattcgtc 1988461 cgtcttcaag cgttaccgtt tcgccttttt tgattttctg atatacaggt ccgggcggga 1988521 tgttcatttc ttttaatacg tcagccttca aggaacccgg tacgtctttt tcctgcacac 1988581 ggtacccgaa ggcttccact ccatgaataa cagataccgc tgtgacaata aactgatcgt 1988641 cctcaaacac gattccttct tcaatttcct ggatcgcaag cggatatgtc aaatgggttt 1988701 tcgtgacggc aaggcttgtt tcaataaacg ccttgatccc tttaggtccg tacactgtca 1988761 gctcgtcctc tccgccttga aaggaacggc tccccagaag ccccggaagt ccgtatacat 1988821 gatcgccgtg catgtgtgta ataaagattt tctctatttt acgaggttta atcgttgtat 1988881 gtaaaatttg atgctgtgtg gcttccccgc agtcaaaaag ccataccgaa cgcctttctt 1988941 caagcaattt taatgccacc gacgttacat ttctcgcctt ggcggggatg ccggctcccg 1989001 tccctaaaaa aagtaattcc acgtttcctt cctcctacta gaaccagata cctacaagaa 1989061 tacaggatca agcggaaaat gtgaatcttg cctctgaaaa gaacaatcct ttcgtgctag 1989121 aaacattttt tcagcattct gcttaaaaaa gggcttaaat gtttgctttc gttgaatttt 1989181 agatttaaaa tgaaggaaat atacggggtg tactaaaata aagcttcgaa taaagtgagg 1989241 tacttttagt gaaaacaaac caacaaccaa aagcagtaat tgtcatattc ggtgcaactg 1989301 gagatttagc aaaacgaaaa ttgtatccgt ctattcaccg tttatatcaa aacggacaaa 1989361 tcggagaaga gtttgcagtg gtaggagttg gaagaagacc ttggtctaat gaggatcttc 1989421 gccaaactgt taaaacatcc atttcctcat ctgcagataa gcatatagat gatttcacgt 1989481 ctcattttta ctatcacccg tttgacgtga caaaccctgg ttcttatcaa gagctaaacg 1989541 tattgcttaa ccagctggaa gatacatatc aaattcctaa caacagaatg ttctacttgg 1989601 caatggctcc tgaattcttc ggaacgattg caaaaacatt aaaatcagag ggtgtaacag 1989661 ctacaaccgg ctggtcccgc cttgtcatcg aaaaaccgtt cggccatgat ctgccaagcg 1989721 cacaggcatt gaataaagaa atccgcgaag catttacgga agatcaaatt tacagaatcg 1989781 accattatct aggcaaacaa atggttcaga acattgaagt gattcgattt gccaatgcga 1989841 ttttcgaacc gctttggaca aaccgctaca tttcaaacat tcaaatcaca tctagcgaat 1989901 cactaggcgt tgaagaccgc gcaagatatt acgaaaaatc aggcgccctt cgcgacatgg 1989961 tgcaaaacca tattatgcag atggttgccc ttcttgcaat ggagccgcct atcaaattga 1990021 acacagaaga aatccgcagc gagaaagtga aggtgctgag agcactgcgt cctattgcaa 1990081 aagacgaagt ggatgaatac tttgtgcgcg gacaatatca tgctggtgaa attgacggtg 1990141 taccggttcc tgcttataca gatgaagata atgtcgctcc tgactccaat acagaaacct 1990201 ttgttgccgg caagctcttg atcgacaact tcagatgggc tggtgttcca ttctacatca 1990261 gaaccggaaa acgaatgaaa gaaaagtcca caaaaattgt cgttcaattt aaggacattc 1990321 cgatgaacct gtactacggt aatgaaaaca acatgaatcc gaacttgctt gtcattcata 1990381 ttcagcctga cgaaggcatt acgctttact taaatgctaa aaagcttggc ggagcagcac 1990441 acgcacagcc aatcaaactc gattattgca gcaattgcaa tgacgagttg aacacccctg 1990501 aagcatatga aaaactaatt cacgactgtc ttcttggcga tgcaacaaac tttgcacact 1990561 gggatgaagt tgccctttct tggagctttg tcgactctat ttctgaaaca tgggcagcaa 1990621 acaaaacctt atctcctaac tacgaatcag gctcaatggg accgaaagaa tctgatgatc 1990681 ttttggtgaa agacggctta cactggtgga acatataata agaagaaaaa agccgaaaat 1990741 gtttacaagc attttcggct tttttacgct gaacaaaggt ataacaatct ccttaataac 1990801 aaaaccccca aagcttaaga gcttcggggg tttctattga ttacttcatc cattcagtat 1990861 ggaagatgcc ttctttgtca gtacgctcat aagtatgagc gccaaagtag tcgcgctgtg 1990921 cttggattaa gtttgcaggc agtacggctg tgcggtagct gtcatagtag gctaatgcgc 1990981 ttgagaatga tggcaccggc acaccttggg caactgcaag tgaaatcact tggcgaagcg 1991041 ctccttgata gctttctaca atattcttga aatagctgtc aagaagcagg ttgtcaagct 1991101 caggctcgcg atcgtaagct tctttgatct tctgaaggaa tgccgcgcga atgatgcaac 1991161 caccgcggaa gatcatagcg atttcaccat atttcagatc ccagttgtat tcttcagaag 1991221 cagctttcat ttgggcaaat ccttgcgcgt atgaacagat tttactcatg aacaacgctt 1991281 ttctgaccgc ttcaatcagc tcttctttat tttctgtaac aggcttcact tctggtcctg 1991341 aaagaagtcc gctcgctttt acacgctctt ccttcatagc tgagataaag cgtgcgaata 1991401 cagattcagt aataatcgga agcggaacgc ctaagtcaag tgcgctttgg cttgtccatt 1991461 ttcctgttcc tttttggcct gctttatcaa gaatcacatc aacaagcggt ttgcctgttt 1991521 cttcgtcttt ttttgtgaag atgtcagccg taatctcaat caggtagcta tcaagctcac 1991581 ctttattcca ttcagcgaaa acttcatgaa gctcatcagc agaaaggccc agcacctgtt 1991641 tcagaatgaa atatgattca gagatcagct gcatatctcc gtattcaatt ccgttgtgca 1991701 ccatttttac gtaatggccg gcgccgtccg gaccgatata tgtcgtacaa ggttctccgt 1991761 caacttttgc agaaatggct tcaagaatcg gttttacaag ctcatgtgct tctttttgtc 1991821 cgccaggcat gatagaaggt cctttaagcg ctccttcttc tccgccggaa acgcctgttc 1991881 cgataaaatg aatgccgctt tcagcgagtt ctttgttacg gcgctgtgta tctttatagt 1991941 atgtattacc gccgtcaatt aaaatatcat ccttctctag atgaggaaga agagattgaa 1992001 ttgtcgcatc tgttgcagtt cccgctttaa ccattaataa gattttgcgc ggtgtttcca 1992061 aggattggac aaattcttca atgctgtaag tgccaacaac attttttcct tttgcctcct 1992121 gtaaaaactc ctcagtttta ctgcttgatc tgttgtaaac agaaacagaa aatccccggc 1992181 tttcgatatt taaagccaga tttttaccca tgaccgcaag tccgataacg ccgatttgtt 1992241 gttttgacat attctaacgt cccttctgca aacgtttaat cattttaaaa tttaaattaa 1992301 aataaaatga tatttataat aaagaaatta ccatacattc accctttttt tcaagcgatt 1992361 cagcttttct tttcatcttg aaaaaaatct ttattaaagc ttgttccctt tgttttgctc 1992421 tcctcttttt ttaacgttgc cccttttctg atcagtttgg taccgtactt tttattcagc 1992481 ttttccatca tctgctgaat gggctcatcc ttcgcatctt cattaaagct gaacaaatcg 1992541 agctgtttat aggcctgctc tttttctact aaatccgttc cggtaatgcc aagcagcctg 1992601 acaggatttt tattccaatg tttaaaaaag aggtgctccg cttctttcaa aatgtcattt 1992661 ttttgatcaa tcgggtttct cagcgtagtg cttcttgtga tggttctcca atccgcatat 1992721 ctaatcataa taaaaagctt cgaagccatg acttccttgc gctgtaaacg gtcactcaca 1992781 gaagcggcaa gctttctaaa aacgcctaac agctcttctt catcactgga atcatgggaa 1992841 agtgtcgatg agttgccgac gcttttaaat tcgtaaatgc gctccgggtc aaccggcgca 1992901 tggtgaatgc catttgcttt atttttaagg cgcggaccgt tgatgccaag caggcgcttc 1992961 agcgagtgtt catcagctgc agctagctct ccgattgtat ggatgccgag tcccttcagt 1993021 ttttccgctg tctttttgcc gactccgtgc atctctccaa caggaagcgg ccacaggata 1993081 tcgggcactt gcctctttct taagatcgta attccaagcg gttttttcat atcagacgcc 1993141 atcttagcga gaaatttatt cggtgcaatc cctatgcttg acgggagcag cagctctttt 1993201 tgcagcctgc tttggatttc ttttgccgtc tctagagcgc ggctgctgta tggtgtatcg 1993261 gtcatgtcca tatagccttc gtcgatggag acaggctcca ctaggtcagt atattcacga 1993321 agaatggtaa acatcgctcg tgaagagttt ctatagcggt caaagttcgg cggaagaacg 1993381 atgagctcag gacaatggcg cttcgcttgc caaaccggca tcgttgtttt gacgccgcgc 1993441 gctcttgctt cgtagctgca tgttaccaca atgccctttc gctcctttac gtttccggca 1993501 actgcgaccg gctttccccg gagagccgga tcatatgcca tttcaaccga cgcataaaag 1993561 ctattcatat caatatggaa aataattcgg ctctttcccg gcataaacaa atctcctttt 1993621 cggtcattag acaacagctt gtacatatag taaaatgaag ctattgaatg gatgtgatga 1993681 caatgtttgt ggaatcgata aatgacgttt tattcttagt cgattttttc acaattattc 1993741 ttcctgctct aacggcaatc gggattgcat tcctcttacg ggagtgccgt gcgggcgagc 1993801 aatggaaatc aaaacgaaca gatgaacatc agacggtctt tcacattaac cgaacagact 1993861 ttcttattat tatatatcat cgcattacaa cttggatacg taaagtcttc cgcatgaatt 1993921 cgcctgtgaa cgatgaggaa gacgccggtt ctcttctttt ataaaccgca tttataaaaa 1993981 ggaggagaac aaaattgtta aaaacatatc aaaaactttt ggctatgggt atctttttga 1994041 tcgtattatg ctcgggcaat gctgcatttg cagcgactaa tcaggtggga ggcctcagca 1994101 acgtaggttt tttccacgat tatttaatcg aaccgttttc cgctctgctt aagggtgttg 1994161 ccgggctgtt tcacggagaa tacggactct ctattatcct cgtaaccatt attgtgcgta 1994221 tagttgtatt gcctttgttt gtcaatcagt tcaaaaaaca gcgcatcttc caagagaaaa 1994281 tggccgttat taaacctcag gttgacagta tccaggttaa gttgaaaaag acgaaggacc 1994341 cggaaaagca aaaagagctg caaatggaaa tgatgaagct gtatcaggag cataatatca 1994401 acccgcttgc gatgggctgt cttccaatgc tgattcagtc tccgattatg attgggcttt 1994461 attacgcgat tcgctcaaca cctgaaattg cgtcacactc gtttctatgg ttcagtttag 1994521 ggcaatctga tattctcatg tcccttagtg cagggattat gtattttgtc caagcctata 1994581 tcgctcaaaa actgagcgcg aaatattccg ctgtcccgca aaaccctgca gcgcagcaat 1994641 ccgcaaaatt gatggtgttc atcttccctg tgatgatgac gattttctcg cttaatgtgc 1994701 cggcagccct tccgctgtac tggtttacaa gcggactgtt tttgacagtg caaaacatcg 1994761 tccttcagat gacgcatcat aaaagtaaaa aaacagccgc tcttactgag tcggtgaaat 1994821 aaaaaagcaa ccccgtgcaa aaagccgggg ttgttttttg ttacttgcaa agtaccgcgc 1994881 caaacagtct tgtttatcat ggctgaagca gaaatggcca tcctaaaaaa tagccgtatc 1994941 gtttaaaaag aaggaaatcg ggaatacctt tactcacctc caaccgaaag gagcctatac 1995001 gttgacggaa cgctttcagc aaaaaaatat ttctgtacct gatggaatct ggatcatgag 1995061 acaaacctgg aatgatgtct tatttgctca ctggcctgtt gatgtttcta tccttcgcgc 1995121 tttggtaccg tccgttttag aattagatac atataacggg caagcttgga tcagcatgct 1995181 tccctttatg ctcacgaacc tgagggcgcg ttatctccct gtcattcccg gtgcgcgtgc 1995241 atttcctgag cttaacctcc gcacctatgt cacgtataaa ggcaagcccg gcatttattt 1995301 ttttagctta gatgccgatc atcgtctggc ggtccttggc gctcgcacat tctttcatct 1995361 gccttatttt tacgcggata tgaagtccga aaaaaacggt gatgccattg actatgtcag 1995421 caagcggaaa aatgacaaag aagcagcatt ccacgccgca taccggccaa tttcagcgcc 1995481 ttttacagca gaaaaggatt cgctcgatta ctggctgaca gaacgataca ggctctacac 1995541 cacttatcgc aataagctct attacgaaga catccatcat catccgtggc tgctgcaaaa 1995601 cgccgaagca gaaatttcag tcaatacggt gactgatgct cacggtatta cattgccgga 1995661 gtcagacccc ttgcttcatt atgctaaaaa acaggatgtg ttattttggc cgcttaggaa 1995721 atggagctaa aaaaacccga tgcgggaaat cgcactcggg ttttcttttt ttattttgcc 1995781 gcctcttcaa taatggcaac aaccatttct gccgttttaa cgagctcttc gatcggcatt 1995841 ttttcatttt ttgtatggat ttgctcataa ccgacagcaa gattgaccgt cgggatgcca 1995901 tgaccagcga ttacgttcgc gtcgcttccg ccgccgctcg tttgcagctc gcttggacgt 1995961 ccgattttag cagccgcttt tttcgcgatt tcaacaactt ggtcgccgtc ttgatattta 1996021 aagcccggat acataacctc aatttcgact tctgcgcgtc cgcccatatc agcagctgcc 1996081 tcttcaaaag cagctttcat tttttgaacc tgagcttcca ttttctcagg aactaaagag 1996141 cgcgcttcag caagaatatg aacttcgtcg cacacaatgt ttgtttgtgt gccgccttca 1996201 aaccggccga tattagctgt tgtttcttca tcgatacggc ccaatggcat ttttgagatg 1996261 gctttgctag cgattgtaat cgctgaaatg cctttttcag gttcaacccc ggcgtgagcg 1996321 gttttcccga aaattgccgc tcttaccttc gcctgtgtcg gcgcggccac aatgatattt 1996381 ccgacttttc cgtctgaatc aagagcatag ccgtaggatg cagtgatcat agaacggtca 1996441 agcgccttcg ctccgatcag acccgattct tcccctactg tgatgatgaa ttcaatcgtg 1996501 ccgtgttcaa tattttcttc tttcagcacc ttaatcgcct caaacattgc agccaatccc 1996561 gctttatcat cagcacctaa aatcgtcgtg ccgtcagttt tgacgtaacc gttctctaca 1996621 actggtttta cgccgtttcc gggtacaact gtgtccatat gagatgtaaa atagatcgta 1996681 tctgtttgtt ttgtcccttt tagcgtgcaa atcaggttac cggctccgtg gcccgtgata 1996741 tccattgtat cgtcttcttt aacgtccaca cctaaatcag aaaattttcg tttcagcact 1996801 ttgcagattt cagcttcgtg ctttgtttct gagtcaattt ggacaagctc taaaaattct 1996861 tccagcaggc gtttttcatt caccatttgt aagtccctcc atattaaagc ggtatgttac 1996921 cgtgcttttt tttcggtctc tcttctgtct tatgtgtaag catatgaaaa gcttgaatca 1996981 gtcttcccct tgattcttcc ggcaaaatga tgtcatcgac cattccacaa gcggccgctt 1997041 tgtatgggcc ggcgttttgc tttttgtatt cagcagtttt ttcgcgtttc gtcttttgcg 1997101 ggtcagctga agctttgatt tccttttcat acaaaatcga tgccgcacct tctggaccca 1997161 tcactgcgat ttcagcattc ggccatgcaa acacaaggtc cgctccgatc gctttgctgt 1997221 tcatggccac ataggcgccg ccgtacgctt ttctaatgat gagtgtgact tttgggacag 1997281 tcgcttcagc ataagcaaac aataattttg ctccatgcct gatgattccg ttgtgctctt 1997341 gctgaatacc cggcagaaac cccgggacat cttcgacagt caacagcggg atatcaaatg 1997401 cgtcacaaaa acggatgaac cttgctgctt tatcagcagc gtcaatcgtc aggcttcccg 1997461 ccagatgctt cggctggctc gccacgatgc cgattgcttt ttcacccagc cttgcaaacc 1997521 caatgacaat gttcttcgca aaaaatggct gaatctcaaa aaaagactgc gggtcagcca 1997581 gctccctaat caccttccga acatcataag gctttgtcgt atcagcaggg acaagacggt 1997641 ttaataacgg tctggacgcc tctttctctg gcttcggctc tgttgtccgg ccattcagcg 1997701 gcaaataaga cagtagtttt ctcacccctg tcagaacctc cttctccgta tgcccggaaa 1997761 agtgggcgtt tccgctgacg gcattatgta tccccgctcc gcctaagctc tccgcatcaa 1997821 cctgttcccc tgtcactttt tcaatcacct tcgggccggt aataaacatc cggccagtct 1997881 gttcagccat aaatataaaa tctgtgagtg ccggagaata tacagcgcct ccagcgcacg 1997941 gccctaaaat aaccgatatt tgcggaatga ctccggaata taagacgttt cggtaaaata 1998001 tgtgaccgta tccatctaat gataacacac cctcttgaat tctcgcacca cctgagtcat 1998061 tcagcccgat aatcggcgcc ttattttttg ctgccagatc catcaaagcg cagattttcc 1998121 tggcatgggt ttcgccaagc gcccctccgt acactgtgaa gtcttgcgca aatacataaa 1998181 ctgagcgacc gtcaattgtg ccgtaccctg tcacgacccc atcccctaac atgcgctgtt 1998241 ctcttgttaa cacttgactt tccatgaagg ggtgtaattc gataaagctg tcctgatcta 1998301 gaagaaatat gatcctttcc cgagcagtga gcttgccctt ttgccgctgc tgagccagct 1998361 tttcccgtcc tccgccttct tctgcctgct tgcgtttcgt gtaaaaatga tccatgtgct 1998421 cattcatgct cattgtgttg gtctcctttc ggttcacaaa gctctacaag aacaccgttt 1998481 gtttcccgag gggaaataaa cgcgatcttt ttcccgttcg ctccctgtct tggaaacctg 1998541 tcaatcaatt gaacatgctg atcagacaat gcttgaagct gttcagatag gcagttgcac 1998601 aaaaacgcaa tatgatgcag tccctgccct ttcttctcca aaaataaatg gacggggctg 1998661 tcagctgtca acggctctat cagctcaagt ttgacgctac cagcttgaaa aaaagcaaca 1998721 ttcacctttt gctcttcaac cgtttcttga tgaagaaatg caagccccaa tacattttca 1998781 taaaagcttc ttgcatcttt tatcgaaaaa acggctatcc cgatatggtc aagcctgttc 1998841 attttcatcc ctgctttcgc taatagatat cgcttgtccg cccattcaaa acacgctaaa 1998901 atatagacag attgtttaag gagtgaaaat catgtctcaa aaactgatga aaagcgtttt 1998961 gatcgtgatt ttgggagttt ttattctttc aactgtactc tcaggaatcg tcatgtttct 1999021 ataacgataa aaaagcaggc gccttattca atgggaatat cctgcttttt tatcagagct 1999081 ttatgctcga tggcaatctc ctcaaaagag cggttgtcgt ccgtgatcag cactctcgtt 1999141 cctactggta tcgtttgaaa caaatgaaca acctcatcgt tatgcatacg tatacagccg 1999201 ttagacacaa attttcctac tgattcctct cggtttgtcc catgaattcc ataaatccgc 1999261 ccgtccgttc ctttcgcgtc aaatccgatc catcttgccc caagcgggtt atcaggagat 1999321 cccccttcaa tatttttctt tctgtagtaa ggattttccg cttttaccgt taccgaaaac 1999381 tctccttcag gcgtcaaatc atctgttttt ccagtcgcca cactatacac gccttctact 1999441 ttgttgtcga ggataacagc aagttcattt gttcgcttgt tgacaataac atacggatca 1999501 cccggcagcg gattttcgcc gagcggccaa atcggtgaaa tcatcatgaa aatcgaacat 1999561 aagaaaaaac gcataagctc ctcctttttc attaggttga ccaatgaagg aagagctcat 1999621 gcgaatcatc cgagtgattt ttgcgctttt attcctttaa aataactttt aatcactaaa 1999681 tattgttcca tttcgccgag aagatggaag agagcggccc tcgcttcaaa ttcctctcta 1999741 gtcgcaggaa gcggcatctc ctcaaattct tttctcatgt cagcaagtct tttcagaaat 1999801 ttgtatgctg tattcccagg gtgtatcgcc tcccgcaaat catgaataaa ttcagcgatc 1999861 atttttccct gatctaccgt gatggagatc gatgtcactt tagggagaag gcgttcgata 1999921 atttcaaatt gcttttctct cattttaaaa taatgataat gcagattttc ataacgcaaa 1999981 atgtggtttt gcacatctcg atatgccagg tttttagcct ccgtaatgag ctggtgcgtt 2000041 tccggaattt cttttcctga ccaatcttgc tcaccagtta acaaataccg ttcgatttct 2000101 gcaaaaatga cagcaaagtt atcctctatc tttttgcggt aggcaatcag tttccggtca 2000161 agactaggca tatacaagtt catcaataga gcgacgccga tgccaaccgt aatcagctga 2000221 acttcattcc agatgaaagt aggcgtaatg ccgccggaca tgtataaatg aaggataata 2000281 acagaactgg tgacgatacc ctcgttaatt tttaacagaa ccgttatcgg aatgaatatc 2000341 aaaagaagcg ctccgatcac aaacgggtgg tagccaataa gctcgaaaaa gagataagaa 2000401 aaagcaattg ccagacagca tgccgaaaag cgggcccatg aggcctgaag cgaccgtttt 2000461 tgtgtgattt gtatgcacaa aatggtgatg attcctgctg atgcgaagtt ttgcaaatgc 2000521 aataactggc ttatataaat agccaaagct gttccaagcg cggtctttat tgtgcggtaa 2000581 ccaattttaa acatgtcgga ctccatttct atttgtttct tcaataaaaa agaagaggcg 2000641 gccagccttc ttctttttta tattctataa tattttctct aaaaagtcct gcgctctttt 2000701 ggattttggc gacataaaaa attccttcgg attgccgtct tcgacaatca ttccttggtc 2000761 cataaacagc acacggtctg ccacttcttt tgcgaagccc atttcatgtg tgacaatcac 2000821 catggtcatg ccggtttcga ccagctcttt catcacctgt agcacttctt tgaccatctc 2000881 tggatcaagg gcggaggtcg gctcgtcaaa cagcatgatg tccggattca tcgcaagagc 2000941 cctggcaatc gcgacacgct gtttttgtcc gccagacaaa cggtttggat agtcatttcg 2001001 cttttcaaac aaaccgactt tgcggagcag gtcctcagct ttctcctgtg cagcctgttt 2001061 tgattctttt tttacattga caggcgcgta catgatgttt tcgagaaccg ttttgtgcgg 2001121 aaagagatga aaatgctgaa aaaccatccc gatgttttcc cggaccttta atgtgttggt 2001181 tttcggcttc gtaatctctg tgtcttttat tgtaatggtt ccgccgttag gcttttccaa 2001241 caggtttaaa cagcgtaaga acgttgattt gcctgagcct gaaggaccga tcacggcaac 2001301 aacctcaccc tcagcgattg ttgttgaaat gttttttaat acttcgtgtt tcccaaatga 2001361 ttttgacagc ttttcaacct taatcattgg atttcagctt cctttctaca gccttgccga 2001421 taaacgttaa aatcaggaca agcacataat aaatcaatcc cgcgataatg agcggctcaa 2001481 ggtaattgta agtggcggcg ccagcttgat atgcgcgtct catgacatca ccaagcccga 2001541 tgacggtgac gatcgccgat tcttttgtta acgtaattaa ttcattcaca attgcaggtg 2001601 atatattttt gaaggcctgc ggcagcagca gatccttcat catttttcca tacgggacac 2001661 cgagtgcaac agcagcttct ttttgccctt tatcaatggc attgattccg gctctgataa 2001721 tttccgatac ataagcggcg gaattcaaag acaatgcgac aaccgcagcc caaaactggt 2001781 caatttgaaa tccgagcagc tgaggaaggc caaaatagac aatcataagc tgcagcacta 2001841 aaggcgtgcc tcggaacact gatgtataaa aatcagcgat ccagataaac gggcggaatg 2001901 tgctgatctt gcataagctt agcacaatac cgagtataag tccgataata gcagatacaa 2001961 caacaatttt taatgtaatt gccaagcctt ctaatataaa aggaatttgg gggatcgttg 2002021 ctgaaaaatc caaattcata gcctttgtct ccttttctta caggaaaaaa gtttcctatt 2002081 caataaaaag gctcaacgaa aaagttgagc cgcttttttt tacttctcgc cagtgaacca 2002141 ttttttcttc aatttctcaa gctctccgtt atcttccatt tccttgagcg ctttattgaa 2002201 tttgtctgtc agttcactgt cctttctgaa agcaattgct gaaccggctt cttccgcttt 2002261 cgcatcagga atcacaaagc cttgcaggtc atcatttgat ttgaaatacc cttctgcaac 2002321 aatgtcttca ataatcgcgg catcgaagcg gtcagatttg atttcctgca ccaaatcaga 2002381 aattctgttg cggtcttctg ttttaaaacc atattccgga gaaagctctt tccccttctc 2002441 ttcctgaata gagccaagct gaacgccaac tgtttttcct ttcaggtctt tcaaagattg 2002501 aatgccgctg tcttttttgc tgacaatcat atggttcgct gtgtaataca catcggaaaa 2002561 atcaacttgt tttttacgct caggcgttgg tgtcattcct gacagaacga gatccacctg 2002621 ttttgattta agcgctgtaa ttaagctgtt gaagtccata tcctgcactt caatttcata 2002681 gcctgccttc tttgccagag cttttgccag ctctacatca aagccgacaa tattatctcc 2002741 ttctttatat tcaaacggtt tgtaatccgc cgaagtaccc ataattaatt ttttctttcc 2002801 gctttctgaa cctgaattgc ttgagccgca cgcagttaat gcaaaggtga tgcaagcagc 2002861 cacaagtaat aagagccatt ttttcatgat ccatttcccc cgtattcatt acttttggtg 2002921 tatttgaata tttattcgtt aatttgtatt ttaaacagtt tctcattttt atgcaatact 2002981 atttttaaaa attatcttta ggcttatctt tccagtgatc tcttctgata ttactagata 2003041 aaaattaaat cgctgtacaa tccgattgaa taatccctta atatttattc atatatcctt 2003101 ggaaatttat gcacaaaaaa acccgggctg ctttgagcat ccgggttgtt cgtcttatac 2003161 ttcttcacaa tattcttcaa aggcttcctg cagctttgcc actacagcca tcggctcatg 2003221 gccttcaatt tcatgacgct ctaccatttt catgatcttt ccgtctttca aaatcgcaaa 2003281 ggacggagaa gatggtggat aaccttcaaa atagtcacgc gcacgcgctg tcgcttcttt 2003341 atcctgtccg gcaaaaacgg tgacgagctg atcaggtctt ttatcatagt gaacggaatg 2003401 gtaggctgcc ggtcttgcaa ttcctccggc gcatccgcaa acagagttta ccatgacgag 2003461 cgtcgttcct tttttcgtaa gtgcctcatc cacctcttcg gctgttttaa gctcggtgta 2003521 tccggcagct gttatttctt gtctcgcttg gcggacaata tcattcataa ataaattaaa 2003581 gtccatgttc aatgaagacc tctccttttt catcatctgt tcttatgata gcaaggaaac 2003641 gtccatatcg gcaaatgact ttgcttcgcc gtgcactttt tttgctcttc gtttactgct 2003701 tacagaaaaa ggggattata taaccagaag taaaataaag gagcagttgt atatgagcca 2003761 ccggaaagcg ttactgattc ataacggaaa tgccggcaac aaaaatatag aaaaagcact 2003821 tggtgctgtg gtgccggttt tatctcacca tttagatgag gtgattatta aacagacaaa 2003881 gaaaaaggat gatgcgtatc atttttgccg atccattgat gattctgtcg acaccgtctt 2003941 cattctcggc ggcgacggca cgatccatca atgcataaat gctatcagcg ctctagaaag 2004001 aaaacccgct gtcggaattt tgcccggcgg cacgtgcaac gacttttcaa gagtgcttgg 2004061 catccctcaa aatcttgcaa aggccgcgga agcacttatg gcgggaaaaa aaaccagcgt 2004121 agacgtatgt cagatgaatg accgttattt tttgaatttc tgggggatcg gcttaattgc 2004181 agaaacgtcg aatcaaatca acgaaacgga aaaagcatta ttgggaaaaa tcagctattt 2004241 tacaagtgcc ttgcgaaccg tctcatctgc tgcatcgttt ccgatgacat taaaaattga 2004301 tggagaagaa attaaagaag aagccgttat gctgcttgtg atgaatggcc aatacattgg 2004361 aacgaatcga attcctctgc ccgatgccag tattgaagac ggcttacttg atgttctcat 2004421 atgccgcaat accaacctca ccgcgctgcg ggagctgatg agcatggaac aaggctcaat 2004481 tgatcgtttt actggagagt tgtcctatgt ccaggcttcc cgtatcgaga ttgaaacaga 2004541 cactgccaaa aaggcggata tggatggaga agtttataca catacacccg cagtcattca 2004601 ggtcctgcca cagcatatcg acatgcttgt tcccgcaaat gaataactgt cataaggctt 2004661 tagaaagatt ttgcaaatcc gttgactctc ccctaggagg aggtcttaca gtataaggga 2004721 tacacacttg aaaaagggga agtcatatgg agaagaaaaa tattacctta actatattat 2004781 taaccaattt atttattgct tttttgggga tcgggcttgt gattccagta acgccgacca 2004841 ttatgaatga attgcattta tcggggaccg cggtcggcta tatggttgcc tgcttcgcta 2004901 ttacacagct cattgtctca ccaatagccg gacgatgggt tgatcgcttc gggcgcaaga 2004961 tcatgatcgt aatcggcctg ttgttcttta gtgtgtcgga gtttttgttc ggcattggaa 2005021 aaacagttga gatgttattt atctcccgta tgctgggcgg tatcagcgca gccttcatta 2005081 tgcccggggt cacggctttt attgcagata tcacgaccat taaaacacgg ccaaaagcgc 2005141 tcggttatat gtcagccgct atttcaacag gatttattat cggccccggc atcgggggat 2005201 ttttagcaga agtccattcc cggctgcctt ttttctttgc ggcagctttt gcactgttag 2005261 cagccatttt atcaatcctc acgctgcgcg agccggaacg aaaccctgaa aatcaggaaa 2005321 taaaaggaca gaagacaggc tttaaacgaa tttttgcccc catgtatttc atagcttttc 2005381 tcattatctt aatttcgtct tttggtttag catcatttga atctttattt gcattattcg 2005441 tggatcataa attcggattt acggccagcg acattgccat tatgattaca ggaggagcga 2005501 ttgttggcgc cattacgcaa gtcgtcttat tcgaccgctt cacaagatgg tttggcgaaa 2005561 ttcatttaat tcggtacagc ttaattctct cgacgagtct ggtattcttg ctgacaacgg 2005621 tacattcata tgttgcgatt ctgctggtga cagtcaccgt atttgtcgga tttgatctca 2005681 tgcggcctgc ggtaacgact tacctgtcaa agattgcggg aaatgaacag gggtttgccg 2005741 gcggtatgaa ttcaatgttt acaagtatcg gcaatgtatt cgggcctatt atcggcggaa 2005801 tgctgttcga tatagatgta aactatcctt tctactttgc aacggtcacc ttagccatag 2005861 ggattgcact gaccattgct tggaaagcgc ctgcacatct taaagccagc acgtgataag 2005921 aagcgcattc tttgtgtact gcaaagaatg cgcttcttct ttatactgat gatagaagga 2005981 gtgatggcat gaaggaatcg tattactcaa ttggggaagt atcaaaactg gcaaacgtgt 2006041 cgataaaagc gctccgttat tacgataaaa ttgatttatt taaaccagcc tacgtcgacc 2006101 cggataccag ctaccgctat tatacagatt ctcagctcat tcatctggat ttgatcaaat 2006161 cattgaaata tatcggcaca cctttagaag agatgaaaaa agcacaggac ttagagatgg 2006221 aagaactgtt tgctttttat acagagcagg agaggcaaat cagggagaaa ttagactttt 2006281 tatcagccct ggagcaaacc atttcattgg tgaaaaagcg gatgaaacgg cagatggaat 2006341 atcccgcgct cggtgaggtg tttgttttag atgaagaaga aatacggatc attcagacag 2006401 aggcagaagg aatcgggcct gaaaacgtgc tcaacgcctc ctacagcaaa ttaaaaaaat 2006461 ttatcgagtc agcagatgga tttacgaaca atagctacgg cgctactttc tcttttcagc 2006521 cctacaccag cattgatgaa atgacttacc gtcatatttt cacacctgta ttgacgaata 2006581 aacagatttc atcaattacg ccggatatgg aaatcacaac gatccctaaa gggaggtatg 2006641 cgtgtatcgc gtataatttt tcgcctgaac attattttct caacttacag aagcttatca 2006701 aatatatcgc ggaccgccaa ttaacagttg tcagtgatgt atacgagtta atcataccga 2006761 ttcattactc cccgaaaaaa caagaagaat atcgagtcga aatgaaaata cggatcgctg 2006821 aataataaag catagaaaaa gagcattttt tgaaacaaaa cttcaaaaaa tgctcttttt 2006881 gcttatttag taaacagatg tcttctcgtc aatcgattct aaaatttgtt tcactcgtcc 2006941 gaggaatcgt ccgcacacga gaccgtcaag cactctgtga tctaatgaca ggcacagatt 2007001 aaccatgtct ctgacagcaa tcatgccatt gtccatgaca accgggcgtt tgacgatgga 2007061 ttctacttga agaatcgcag cctgagggta gttgataatg cccatcgact gaacagaccc 2007121 gaacgaacct gtgttgttga cggtaaacgt gcctccctgc atgtcatctg cagtgagttt 2007181 tccgtctctt acttttttag ctaggccggt aatgtctttc gcaatgcctt taattgtttt 2007241 ttcatcagcg tttttaatca ccggaacaaa taaagaatcc tctgtggcaa ctgcaattga 2007301 aatattgata tcctttttct gaataatttt gtcccccgcc cacatgctat tcatttgcgg 2007361 gaattctttt aacgcctgag cgaccgcttt tacaaaaaag gcgaagaacg ttaaattaaa 2007421 gccttctgtc ttcttaaaag aatcttttat actgttgcga tatgcaacca tatttgtgac 2007481 gtcgacttcc atcatcgtcc aagcatgcgg aatttctgtt ttgcttcgct tcatattgga 2007541 agcaattgct tttcttacac ctgtgacagg gatttcttta tcaccggctg cagacgcagg 2007601 atatgacgtc tcttcttttg gctcaggttt tgatgcagac ttcggtgcag gagctgctgt 2007661 tttcagctcc tcaggattct gttcttgcac gccgcctgtt tcaattaagc gctgaatatc 2007721 ttttcgtgtg atgcgcccgc cggcaccagt tcctgtcact tgatcgaggt caatgccgtg 2007781 ctctccggcc aaacggagaa cagctggcga gtagcgcttt ttattgggct gatcggctgc 2007841 tccagcactt tttgcaacag ggttctcagc ggcttctgat gctgctggct gttcttgttt 2007901 ttgttcagcc ggattcgcgc cttctgtttc aattttgcaa atcatttctc cgacttgcag 2007961 ggtttggcct tcttctccca caagctctgt tatcgtacca gtaaaagaag acggaacctc 2008021 tgcatttacc ttatctgtca tgacttccgc gatcggatcg tatttgttca ctttatcacc 2008081 gggggcgaca agccatttgc tgatcgtccc ctctgttacg ctttctccaa gctgcggcat 2008141 cgtcatttgt tcaattgcca tgattgtatc ctcccttacg tctttaaaac tccgctaatt 2008201 ctctcatcgc cgcttccact ttatcagggt tgaccataaa gtatttttcc attgtcggcg 2008261 cataaggcat agccggaata tcaggacctg caagccgttt gatcggcgcg tctaagtcga 2008321 acagacaatg ctcggatata attgcggcta cttcgctcat gatgctgcct tcttttgtat 2008381 cttctgtgac caaaagaacc tttccagttt tggacgcagc ttcgatgatg gcttctttat 2008441 caagcgggta aactgttctt aaatccacca catgcgctga aatgccatct ttttcgagac 2008501 gttctgcagc ttgtaaggcg aagtggacac acaggccgta tgtgatcact gtgatgtcgt 2008561 cgccttccct ttttacgtcc gccttgccga ttggcaggac ataatcatca gccggaacct 2008621 cgccctttat cagacggtat gcccgcttgt gctcaaaaaa cagcacgggg tcttcgtcac 2008681 gaactgcggc ttttaagagc cctttcgcgt catatggtgt tgatggcatg acaattttca 2008741 gtccgggctg gttggcgaaa attgcttcga ctgattgaga atgatacagg gctccgtgca 2008801 cgcctccgcc gtatggcgct ctgacgacaa tcggacagct ccagtcattg ttgctgcggt 2008861 agcggatttt agccgcttca gaaataattt ggttgactgc cggcataatg aaatcagcaa 2008921 actgcatttc agcaatcggt ctcattccgt acattgccgc tccgataccg actcctgcga 2008981 ttgcagattc agcaagcggc gtatccataa cgcgctcttc cccaaattgt tcatagagtc 2009041 ccgctgtcgc tttaaacaca ccgccttttc ttcctacatc ttccccaagg acgaaaacgc 2009101 gagaatctcg ttccatttct tctttcatcg ccaaattgat tgcatcaata tatgacatta 2009161 ctgacatttg ttcttcctcc ctacttcgca taaacataat caagcgctga ctcaggagct 2009221 gcatatgggg cgttctccgc ttcatccgtc gcttcattta cgattgccat aatttcatcc 2009281 agcatggttt gttctatctc atcggacagc aggcctgttt cctttaagta agcttgataa 2009341 gtaagcaggg gatcactttt tttcgcttcc tctacttctt cacggcctct gtagctgctg 2009401 tcatcgtcat cactggaatg tggtgtaagg cggtaagaaa tcgtttcaat taatgtcggg 2009461 ccttctcctc tgcgtgccct ttcgcgtgct tctttaaccg cttgataaac ttccagcgga 2009521 tcatttccat tcacagttac gccaggcatc ccatagccta tggcacggtc ggaaatgttc 2009581 tcacatgcga cttgcttatc gtaaggcact gagattgcgt atttgttgtt ttcacacatg 2009641 aaaataaccg gcagcttatg gacagcggca aagtttgccc cttcatggaa atcgccttgg 2009701 tttgaagacc cttccccgaa tgtaacaaag gctgcgatat cctttttctc catacgtccc 2009761 gcaagcgcaa taccgactgc gtgcggcact tgcgttgtaa ccggagatga tcccgtcaca 2009821 atgcggtttt tcttttgtcc gaaatgtccc ggcatctggc ggcctcctga gttcggatct 2009881 gctgcttttg caaacccgga catcattaag tcctttgctg tcatgccaaa cgcgagcacg 2009941 acacccatgt ctctgtagta cggcaataca taatccattt cacggtcaag tgcgaaagcc 2010001 gctcctacct gtgctgcttc ctgtccttga caagagatta caaatggaat tttgccagaa 2010061 cggtttaaca gccacattct ttcatcgatt tttcttgcta acagcatggt tctatacata 2010121 tcaacggctt cctgatcagt cagccctagt gcttgatgtc ggtttgtact cattcaagcc 2010181 cctcctttat gcttttaaaa atgaatggct ttgccatctg cggcaagcgc agcttctcca 2010241 attgcttcag aaagcgttgg atgcgggtga atcgtttgcc cgacctccca cggtgttgcg 2010301 tccagcactt tggcaagacc cgcttcagaa atcatgtcgg tgacatgcgg gccaatcata 2010361 tgaacgccga gaatatcatc tgtatctcgg tcagccacga ttttgacaaa accgtcgctt 2010421 tcaccgtata caagcgcttt tccaatcgcc ataaatggga acttgccgat tttgacatta 2010481 tgcccgttcg cctttgcttc gtcttcggtt aagccgacac tggcagcttc agggcttgag 2010541 taaatgcact tcggcacaag cgtcggatca agcggatgcg gattgagacc tgcaaaatgc 2010601 tcaacagcaa taattccctc atgtgaagca acgtgagcta actgcaggcc accgattacg 2010661 tctccgattg cataaatatg agattccttc gtttggcagc tttcattgac tgaaatcatg 2010721 ccattttcag taacaatatc ggtgttctct aggccgatgc cttcgatatt tgcctgtctg 2010781 ccgatggaaa caagcatttt ctcagcagaa taggtaacgg tttctccgtc tttttccgct 2010841 tgtatgctga tatcgtctga tgtttttgtc attgtgtcag gcagcacttt tgcccctgtt 2010901 atgaactgga tgcctttttt cttaagaaga ctttccattt cttttgaaat ctctagatct 2010961 tcagtcggca atatgcgatc cgcgtattca ataaccgtta ccttaacgcc aaaatcatga 2011021 agcatagacg cccattcgat accgataacc cctccgccga caatgatgat tgactgtggc 2011081 agctcctcca tttggagcgc ctcatctgaa gtcagtacag acttaccgtc cacttcaaga 2011141 cccggaagca ttctcggtct tgatcctgtt gcaatgatca cttgtttcgg gatcagcatg 2011201 tcattttctt cgccatttcc ccgctcaaca gaaattgttc ccggcagcgg agagaagatt 2011261 gacggtccaa ggatacgtcc atatccggtg tacacgtcaa tttttccttt tttcattaaa 2011321 tgatttacac ccgctgcaag cttatcaaca acggcttgct tacgctgctg cactttttca 2011381 aagttgaggg acacgccagc cgtttccact ccgaattgat cggcttcacg agctgtccgg 2011441 tatacctctg cgcttctaag cagcgcttta ctcgggatac agcctttatg cagacatgtt 2011501 cccccgagtt tttccttttc cacaacggct gtttttaagc cgagctgagc ggctctgatg 2011561 gccgcaacat aaccgccggt accgccgccc agaatgacta cgtcatactc agttgccatg 2011621 gtgactcact cctgtctgtc tattcaatac gatattgttt ggattgctct tcgccctgca 2011681 atactcttag cgccccttgg gcaagagact gcagttcatt ttcacccgga taaactaaaa 2011741 cgtctgaaat ccaatctatg tatgatctga tagcagaaac aaagcttttt ccgtacgcaa 2011801 ggcctcccgt cagcacaatc gcttcaactt cgccttttaa cgccgcgctg gctgccccga 2011861 tttcctttgc tacctgatat gccatggcat cataaatgaa gcgggctttt tcatcgcccc 2011921 cttgaatcat ctgttccact tttactgcat catttgtacc gagatagcct aaaagtccgc 2011981 cggtgccaac aagctttttc atgatttctt cttttgtata ttcccctgaa aaacatagat 2012041 caacaagatc tcccgcaggc actgttcctg ctcgttcagg actgaatggt ccctcgccgt 2012101 gcaggccgtt attgacatcc accactcgcc cgcggtcatg gacgccaatt gtaatacctc 2012161 cgcccatatg ggtaataatc attttcatgt tctcatatcg tttgccaagg gaggctgccg 2012221 ctttacgagc gacagctttt tggtttaacg catggaaaat gcttttcctt tcaatttcag 2012281 gcatgcctga aactttcgca agcactgaca tttcgtctac gacaacaggg tcgacgatat 2012341 acgaagggat attcaggccg tcagcgattt cccgcgcgat aatgccgccg agattagaag 2012401 catgctgacc ggcgtagccg cttttcaaat cctcaatcat ctcatcattc actacgtagg 2012461 tcccgccttc aattggccgg agaaggccgc ctcttgcgca gactgcatca aactttgaaa 2012521 tattgattcc ctgttcatga agcgtttcga gaatatggtt tttacgaaat tcatactgat 2012581 caataattcg gtcaaatcgc tgcagctctt ctatgttgtg tctcaatgtt ttttcaaaaa 2012641 tgcttctttc gttatgaaaa acaccgattt tcgttgaagt tgagcctgga ttaattgtga 2012701 gaatgcgttt ttcgtcatgt agcactttca taacctccag atcaatttct taacgtctgc 2012761 ttaatacact gtggccgttt tgcaaaaact ggcttcttga gcggcgcatg cgttcaatcc 2012821 gttcctctgc taagcggtca gccgctaaat atgcaggaat gccgtcacgc tgagaaatct 2012881 caagtacacg ctcgatattg ccgtaaatgc cttcaacttt tttcaatgca cgttctgcat 2012941 tatagccgta aagctcatct gccacgttga tgacaccgcc cgcgttaatc acgtaatccg 2013001 gtgcataaac gatgcccatt tcgtgaattt gatcaccatg gcgtgtctct tttaattggt 2013061 tgttagccgc acctgcgatc actttcgcct tcagctgttt aatggtgtcg tcgttaatag 2013121 tcgcaccaag ggcacacggc gcataaatat cgcagtcttg tgaataaatg tcatcaggat 2013181 ctaccgcacg ggcgccaaaa tcttcaactg cacgctgtac agattgtttg ttgatatccg 2013241 taacgattaa gtttgctcct tcttcatgca ggtggcggca aaggttatag gctacgttcc 2013301 caacaccctg tacagcaatg gtttttcctt caagagagtc ggttccgaaa gcagctttag 2013361 ctgctgcctt cattcctctg tacaccccgt acgctgtgac tggggacgga tttccagaag 2013421 agccgaaagc aggagaaatc cctgtgacat agtctgtctc atcatgaatg atatccatat 2013481 cctcgaccgt tgtgcccaca tcttcagccg tgatgtatct gccattcagt ccttgaatat 2013541 agcggccaaa cgcgcggaac atttcctcat ttttgtcttt gcgcggatcg ccgataatga 2013601 ctgtttttcc gccgccaagg tttaagcctg ccgccgcgtt cttataggtc atgcctcttg 2013661 ccaatctgag cgcatcttca attgccgctt cttcattttc atatgtccac attctcgttc 2013721 cgccaagcgc cggaccaagc gttgtatcat gaatggcgat aatcgctttt aatccagatt 2013781 gttcatcctg gcagaatacc aattgttcgt aatcgtattt ctccatatat ttaaaaagtt 2013841 ccatgttcgt tcctcctaat gtgtgtattc ttcagatgcg catattgcca gcgcaatgga 2013901 atacagttta ttttcagcag agtccgctct gcttgttaaa gcaatcggtg cttttgctcc 2013961 tgtaatgaca gccgccacgc tggccttggc aaaataaatc agtgatttat ataaaatatt 2014021 gccggcctca attgttggga cgagaaggat atctgcgttg cccgctacgt ctcccgaaat 2014081 ttttttctgg gccgcggcaa tttgtgaaac tgcgttatcc aaagcaagcg gtccatcaac 2014141 aatgcagcct ttgatctggc cccttttgta catttgagct agagcagctg cattcacggt 2014201 cgcttccatt ttagggttca ccgtttcgac cgctgcaagg gcagctgctt ttggcatatt 2014261 gttccccact gcatgggcca catgaacggc attttgcaaa atctgccgga gctcttccag 2014321 cgaaggagca atattcattg ccgaatctgt cacaaacatc agccggtcaa aatccggtat 2014381 atcgaagaca gccacgtgag aaaggacact tgctgaccga agcccctcct gtctgttcaa 2014441 taccgcttta agcaaaacag aagtcggcac attgcctttc attaaaacgt ccgctgtttt 2014501 atgatgcaca gcacgaaccg ctaatttcgc cgattcctca ggagtattgg catggacgat 2014561 ttccacttga tgcccttgca tggatgatgt cagctcgttc agttttttgc tgtcgcccgt 2014621 taacaagaaa cgggcggata ggtgctcggc tgccagcttt acagcccgga tcacttcctc 2014681 atcctcagca tgagcaaccg caatggtctt atttttgtgt atcgacgctt tgccgattaa 2014741 atctttcagc ttcatctgtt accacctttc ttgtttcgac tccgcctttt attatgcaag 2014801 ttccatgcca gctcttaagg gtgctgtcat accaggtata ccgaaacatt cgtgcagatg 2014861 tttgcgttta ttctgcaaat tattgcatgc cttcatttgc aaggccatat ttatccattt 2014921 tgtaatataa attccgaatg ctgacaccga gagcttttgc tgtttttgtc cggttaaaat 2014981 gatgcttttc aagcgtttgc tggatcaaat gcgcttcaaa tttttctact gcgacagaca 2015041 gcttttcgcc ttcaatatcc ggaaaatcaa aacctgttcc ctgatctgtg tcattttctt 2015101 tttgctcaag ttcgaataca ggcaagtgat ctttttcaat ccattccata tgcggattca 2015161 gaaaaatcat ggctcgtcca aggacatttt caagctcccg gacattccca ggccaatggt 2015221 aggcagataa ggcgcgcaag gcttgctgtg agagcccttt tacattcctg ccgtaatccc 2015281 ggttgatctt ttggataagt ctgacgctca atgcttcaat gtcctccaac cgctgccgca 2015341 aaggcgggat ggagatcgga tagcgattga tccggtaata caggtcttcc cggaatgttc 2015401 cgtccgccat cgccttttca atatttacat ttgtcgccgc gatcactctg acgttgacag 2015461 ggatcgcttt cgtgccgccc actctgacga tttccttttc ttgaaggacg cgtagcaatt 2015521 tggcctgcat attttgtgtc agctcaccga tttcatctaa gaaaatactg ccgttatttg 2015581 cttcctcaaa taaacccttt ttaccgccgc gcttcgctcc tgaaaacgca ccatcctcat 2015641 agccgaacaa ttctgattcg agcaggtttt cagaaagggc tgcacaattc acgcgaataa 2015701 atttattgta tttccggtca ctttcgttat ggatggcatg ggcgaacagt tcttttcctg 2015761 ttcctgattc cccgcgcagc aagatggttg ccggtgtttt cgcaccgagc ttcgcctgct 2015821 caagcgcaac cagcatttgc tcgcttttgc cgataatgtc gtcaaacgtg tatttcgctt 2015881 caagcgtgcg aataatttgt ctggcgcgat taagctccgc tgtcagcatt ttaatttcgg 2015941 aaacatcgtg aatcacgccg acgctgcctt tcaaaatccc gtccacaatc accggtgcta 2016001 cattaacgat cacttctttt tcattcgggc cgaccttcat tctgacaccg cggacaggac 2016061 gtcttgtttc aagcaccttt aaatgcatgc tttcgccttc ggaaatatca gtgtttgcag 2016121 gcttgccgat gacttctttt tcagaaagcc ccgtcatttt cgtatacgct ttattgatta 2016181 gcaggccgat gccgttttca tcaacgacag aaatcgcctc atcggaggat tgaataattg 2016241 cctccagcat cgtacggacc tgctttaagt tggtcacttc ctctgccagc tcgaccgcat 2016301 cagtgatatc tttaaacaca caaagagccc cgagcagacg tccgccttca tcaataatcg 2016361 gcagtcttgt ggtcacaatt tgcaaatgat cgcctaacag ctgcttctgg ttgtattcag 2016421 gcactcttgt ttttaaaatc cgcggcatct tagtgctcgg aatcacttct tttattgggc 2016481 gcccaatgac ttcctcacgt ttttttccga ccattttttc ggccatatgg ttaaagagaa 2016541 tgatttcttc attgatatca ataaaaatca ttccatcatg ggtggaatta aaaattctgt 2016601 catatttata ggtttgctct tttagcattt gaatcaggtg ctgcttttct tccatcagct 2016661 gaaaaacgat gtatgccatt tttcccggca tgacaatggt atcttcatgc tttctttgaa 2016721 ggagctcgtc aaacacggct tgatcgccgg tagtatgaat gacgatatcc ggtttttgtt 2016781 gtatgtaagg tttccaatca gatgatacgg caatcccata ctgttctgct tctttcaatc 2016841 ccggcgcctc ggggtctttg tcaactacgg caatgatatc tatgatggct gttttaatca 2016901 gaatatgtaa taacgccgtt ccccttttgc cggcacctac tatcagtacc ttttgcatcc 2016961 cgatacccct ttgtatgaaa aaatttgcac acctatttat tccgttgcaa taatttgcac 2017021 aaccctatgt taccacgttt tcttctcttg acaaaatatt ttttccgctg gacaataaag 2017081 gaaatgaaaa gataaagggg ttttctgaag atgagccgac ttcttgcgct tttaatatta 2017141 gtcatccccg gggctatttc tgctttaggc attaaactga tgagagatac acttttcggc 2017201 catacaatca agccattttc agctctttgg ctccaagggt tgtcaggatt catctttttt 2017261 gcgatcggcc tctatgtgct ggccgggttc attttataca gagacagaaa acgcaatcaa 2017321 gtcagcccgc gattcagaaa acgatagctg aaaaaaagcc ggagaatgct ccggcttttt 2017381 ttgttgcatt attcgtcagg caaaacggtc ttggcaatcg ttttgtctaa cgcttcatag 2017441 tcataataag aaatcgtatc gtacagttct tttcgtgtct gcatatcatg aagtccttct 2017501 ttttgtgagc cgtgctcctt catcaaacca aacatccgct cacaagcttt tgccgccgct 2017561 cgaagcgagg tgacaggata tatcaccatg tgaaacccca tatcttcgaa ttcatcggca 2017621 cgataatatg gcgttttccc aaattcagtc atattcgcaa ggagcggaac ggggatacgc 2017681 tcagcaaact ggcggaattc attctccgcc tgtagcgctt ccgggaaaat tgcgtccgct 2017741 cccgcctcaa tgtaagcctc tgaacgtttt attgcggcat caagcccttc ctgcgccctg 2017801 gcatcagtac gggcaacaac aataagggag ggtgccgctt gtttaatggc ttttattttt 2017861 tgcgccattt cctttatcgg aactagctgt ttgccattta aatgtccgca tttttttggg 2017921 agctgctggt cttccatttg aacggctgct accctggctt caagcatctc ccgggctgtt 2017981 cgggcggcat ttaagacacc gccaaatccc gtatcgatat ccacaagcaa aggcagatca 2018041 gctgcacgca caagatcttt ggcccgttca gctatctctg ccgatgtgat gatccctaaa 2018101 tcaggcagcc ccctgctggc tgtataggca gcaccggaca aataaatagc agaaaaaccg 2018161 gcttctttcg caagcaaagc ggccatcccg tcatgggcgc cgggaatttg aagaatgtcc 2018221 ggtgctgaca tcagcttgcg gaaacgcccg gcaagctcct cttgtgacga ttgcttattg 2018281 acgatccacg acatgaaaca aaatccccct tttacatgca gaacatgtct acgaattcat 2018341 ttacgcgcat cgtttgtaat gtctcatagc tggtacagcg ctcataaatg tgtttgtgct 2018401 gtttatcagg aaaatgggtt ttgagattgt cagaaaactt ttccagcagt ttcggcactg 2018461 cttcctctct tcgaaaacga tggccgaggg gaaactcaca ttccaccatt tccgtgctcg 2018521 ttccatcttt aaaatgaacc tgaacggcat ttgagatgga gcgtttatca ggcttcaaat 2018581 aatcctcggt atatgtttta ttttcagtca cttccatttt atcacgaagt ttatctattc 2018641 tcggatcatt cgctgtttca gcttcataat gctgtgcggt gatatcacca aaaagcaaac 2018701 cgattgctgt aatgtattgg aggcagtgat cacggtctgc cggattgtgg agcgggcctt 2018761 ttttatcaat gattcggata gctgattcat gcgttctgat gacaactcgg tcaatctcgt 2018821 caatccggtt ctttacctgc gggtgaagaa tgacggcgga ctccgccgct gtctgggcgt 2018881 gaaattccgc aggataagac actttaaata acacattttc catgacataa gcgtcgagcg 2018941 gacgggcaag cttgatctct ttcttattga ataaaacgtc ttggaacccc caacccggtg 2019001 cactcaaggc tgtcggataa cccatttccc cttttaacga catcagcgcc aaatgaacac 2019061 ctctgctcgt tgcatctcct gccgcccatg atttacgcga gcctgtattc ggtgaatggc 2019121 ggtatgtcct caatgctgca ttgtcaatcc atgcattcga aagcgcattt ttgatttctt 2019181 ctcttccgcc gcccaaaagc tttgctgcaa cagcagttgt cgcaactttg acaaacagca 2019241 catggtcaag gccaactcga tttaagctgt tttctaacgc cagcacacct tggatctcgt 2019301 gtgctttgat catcatctca agtacgtcgc gtaccgttaa cggctctttt ccttcagaca 2019361 gcctcactct tgatacataa tcagcagcgg caaggattcc tcccaagtta tcggatggat 2019421 gcccccactc cgccgccagc cacgtatcgt tgtaatcgag ccagcgaatc atgcagccaa 2019481 tattaaacgc tgccctcaca ggatcgagaa catatgacgt tcccggcact ttgcttccat 2019541 tcggcacagt cgttcctgga acaatcgggc caagcagctt tgtgcattcc ggataccgta 2019601 gcgccaagat tccgcagccc agggtatcca gcaatacatg ccccgctgtt gtatacgctt 2019661 cggcactagt aatctctttc tcaagcacat agtctgtgat ttcttcgata acacgatccg 2019721 ttttcggcat tctaccagct cctttcatga ttttgtttga tatcgcgggc ccatgtaact 2019781 gacacgggga cggaagagcc gattattggc atgctgttcg atcacatggg cgcataaacc 2019841 ggacgttctc gcgctgaaaa agatcggcgt atataaagga atcggtatgc cgagcatcca 2019901 atacactggg gcagcatagt aatccaaatt cgggtaaagc cctttttcct tctccatcag 2019961 ccgctcaccc gcttcgcaca tctcatataa acgatggtca ccggctttat cgcataattg 2020021 ctgcagcgcc tctttcatca tgagtgctct cgggtccatt tttttcatat acacccggtg 2020081 gccgaagccc atgatttttt cttttctttt cagttttgtt tgcaaaagct gctcaaaatc 2020141 agatgtcgtt tttgcctcca aaagcaaata catcacagct tcgtttgctc ctccgtgaag 2020201 attccctttc agggaagcga cagccccagt caaagcccca taaagatctg aatgtgtaga 2020261 tgcaatgacc ctggccgcaa aggttgaatt cggcatctca tgctcactgt acaggacgag 2020321 cgaccggtca aaaatctgtt cttccaatga agacggcaat ttccctgtca tcatgtagag 2020381 aaaattcgca ctgtaggata gggtttgaag cggaagaatc ggttctttct tattaatgat 2020441 cctgtagctg gcagcagtga gggcaggcat tttcccaaga agctgatagg cgcgttcttt 2020501 gtttgcggaa ggagaccgat catcaatttg ccgatcatag ccagcaagtg ccgacaggcc 2020561 ggtacgcaga ccatccattg gatgagtgtc ctcagggagc agctcaagca gacggagatg 2020621 atcagcaggc aggcttgagg cactgtttat tttacgttcc agcgtttcca tttcactttc 2020681 ttctggcagc ctgccctcca gcaataaatg gacaagctcc agatagcttt ttgtttcaga 2020741 aagttctatt aaatcatagc ctcttatcaa aatctggctg gactgcgtgt caagataaga 2020801 aatatgagtt tctgccgcaa tcacaccgtc caaccctgga gaataatgct gtttctcctc 2020861 catatcctca acctccgttt ttgcgttttt tgtctatcag gttccgccaa gcaaatactt 2020921 ggaaataatc agtctttgaa tctcgttcgt cccttcataa atttgcgtca cctttgcatc 2020981 gcgaagcagg cgctcaactg gataatcctt catatagcca tatcccccat aaatttgaac 2021041 ggcgtctaac gccgccttta cggctgcatc ggaagcaaat tgtttagcca tagacgcttc 2021101 ttttccacag tttaggccgc ggttatgaag gtctgcagcg tggtagacaa gatgtcttgc 2021161 cgcctcagct ctagtcgcca tatcagccag cttaaatgat atgccttgat tggctgcaat 2021221 cggccttcca aattgcactc gctgcttcgc ataatcaacg gcatgctcaa gagccgcctc 2021281 tgcaattccg agggcctgtg ccgcaatgcc gatccggccg acatttaaat tcgccatggc 2021341 aatgtgaaag ccatccccct ctttgccaag caaattggct tcaggcactt ctgcattatc 2021401 aaaaatcagt tccgtagtat tggagccata aagccccagc tttctttctt tttttccaac 2021461 ggtaaaaccg ggtgtgtttt tttcaacaat aaaagccgaa atcccgtgcc tgccttgatc 2021521 tggagctgtt aaagcaaatg tgatatagat atcagctgct ccgccattcg ttatgaatat 2021581 tttcgatccg tttaataggt atttgccgtt ctttttgatt gctgttgtgc ggaggctccc 2021641 ggcatccgac cccgagtgag gctccgttag tgcaaatgcg cccaaatggt ctcctgacgc 2021701 gagatttggt atatatttca tcttctgttc ttcgttgccg aaatacagaa tcggattcgt 2021761 gccgactgag gtatgaacgg agagaatcac gccgacagcc gcgctgattc tagaaatctc 2021821 atgaattgcc aaaatataag aaacaacgtc cgctccagca ccgccgtatt gttccggcac 2021881 cggtattccc atcagtccgt gtttacccat ttttttgatc agctgaaagg gaaattcgtc 2021941 cgttttctcc atgatttccg cagcgggagc aatttctttt cgtgcaaaat cacgcaccat 2022001 ttttcgcatc atgacttgct cttgggttac atgcaactcg gccacccccg gatggaatag 2022061 acttcaggaa gtcttctcct catagtcata aaaaccgcgt ccgctctttt tgccaagcca 2022121 gcctgctttg acatacttgc ggagcagcgg gcaaggacgg tatttggaat cgccaaggcc 2022181 tgagtgaagg acttccataa ttgataaaca cgtatccagt ccgataaaat ccgctaatgc 2022241 aagcggaccc atcggatgat tcatgcccag cttcatcact tcatctattg cctccggctt 2022301 cgccactccc tcatacacgc aatagatggc ttcattaatc attggaagaa gcacacggtt 2022361 ggaaacaaac ccaggaaaat cattgacttc taccgctgtt ttccccatct tttccgctaa 2022421 tgccataaca tctaaggccg tttcttctga tgtagccaag cctcgaatca cttctaccag 2022481 cttcattaca gggacgggat tcataaaatg catgccaata acccgttgag gccggtttgt 2022541 tacagcagcg atttctgtaa taggcaagga agatgtattg ctggccaaaa tcgtatgagg 2022601 cgggcaaatg cgatcaagtg ttttaaacat ctcagttttt gccgccatgt tttctgcgat 2022661 agcctcaatc acaatgtccg catgctctgc ctcctcaagt gtttgagaaa tcgaaatgcg 2022721 gttgattacg ctcttcactt ccgtctcggt cctttttcct ttctcagcat cacgggccag 2022781 ctgtttcttc agccgtttca atcctgcctc cgcggcctct ggattcacat catacatccg 2022841 cacataaaag cccgcgtcgg cggctgtttg agcaattccg ctccccatct gacctgcgcc 2022901 agctaccatg atttgtttga tttccattca aatccccttt ttcatcatgt tttaatgaac 2022961 ctgcactaag acggcgtctc cctgtgctgc cccgctgcaa atagcggcaa cgcccagacc 2023021 ccctccccgt cgctttaatt cataaacaag cgtcatgaga attctcgcac cgctcgcgcc 2023081 gatcgggtgg ccgagcgcga tcgcaccgcc attcacattt actttttcaa gatcgaaacc 2023141 tacgattttt tcacatgtca aaacaactga agcaaaagct tcatttactt caaacaagtc 2023201 aatatcttgg acagttaaac cattcttttt caggagcttg ttaatagcaa accctggcgc 2023261 tgccgccagc tcgtgcgctg gcattcccgt agttgaaaaa ccaagaattg tagccagagg 2023321 ccgtttgcca agctcagcag ctttttcctc agacatcagc acgaacgcgc cggctccgtc 2023381 attgactcca ggagcattgc cggctgtgat agaaccgtca cttgcataaa tcggagcaag 2023441 ttttgcgagc tgatccagac ttgtgtcacg gcgaatcgct tcatctttat caacaacgtt 2023501 tggttttcct tttcgaccga tccagttgac gggaacaatt tcatcctgaa acttcccttc 2023561 atcggcggcc ttagctgccc ttgcatgact tctcaacgcc cattcgtcct gctctcttcg 2023621 tgagattgca tattccttgg cagctgtatt tccgtgaaca gccatgtgca cctcgtcaaa 2023681 tgcgcacgtt aatccgtcat acaccattaa gtccctaagc tcgccgtccc ccatccgtgc 2023741 tccccagcgc ccggcgggaa cggcatacgg aatattgctc atgctttcca tcccccccgc 2023801 aacaagtatg tccgcatcct gcgcccgaat catttgatca cataaagtga cagcgcgaag 2023861 gccggaagca cagactttat tcagtgtttc tgacggcaca ctccaaggca ttcccgccag 2023921 acgggcagct tgacgggaag gtatctgccc tgagccggcc tggacaacca tgcccatgac 2023981 gtttccttct acatcatctc cagagactcc agcctgttgc agcgcctcct tcatcacaat 2024041 gcccccaagc tcagcagctt tcacctcttt caaaactccg ccgaatttgc caaatggagt 2024101 tcttgcagca cttacaatga ctgttttcct catggtttca cctcattcag aagatagaca 2024161 gcgcttacaa tttctagttg tcttctatga atgtatgctt tgaaacgggc atgaatgaat 2024221 gaaaaaagaa ggctgcgtca aacagcctcc ttctaacaac tattcatttt tcagcaatgc 2024281 cgaagccttt tctggaaagt cggtaaacat gccgtctgct cccgcttcaa tgagacgctt 2024341 catatcttcc ggacgattga ctgtatacgg ccttacctta atcaaaccgt tcctcatttt 2024401 cttcagtact tcatctgtga cccctgggct gtttatcttc gggtgatagc cggaagccgg 2024461 aatagacgcg atatatcgat ctgcctgata aagcacatct gaagttaata ctgcccgttc 2024521 gatatgcggt gcaagccggg cgcacagcgc caagctgtca tgattaaacg tggataggat 2024581 gactctgtcc tctacattaa atcgcttcac tgcctccagc actttttctt ccattccctc 2024641 atagcggatc acgctgtttt ttaattcaat gttgatgaga aaatcctttt ttaccgccca 2024701 cgagagcaca tcttctagca gcggcacttt tatatcgctg tacgcttgat cgtgaccagc 2024761 ggccgcattc gcagtcttta cctcatcata ggctgtatcc ttcacgaatc ctttaagtga 2024821 tgtcgtgcga ttaagtcttt catcatgaat tacaacaatg cgtccgtctt tcgtcagctg 2024881 tacatcaagc tctatcccat ccgctccggc ttcaattcct ttttcaaatg caagcattgt 2024941 attttcggga aattgacctg atgccccccg gtgggcaaaa atctttgtca tcgtttcacc 2025001 tcaaacccta aagttttctc cattatactt attttgtcgg ctccactcta ggattaaggc 2025061 tgtatcaatc tactgatcat aataagaatc aatgccattg acaatcgcat ctgcggcctt 2025121 ttgctggtat tcttcacttc ccagcttgtc cgcgtcagag ctgttcgtga taaacccaag 2025181 ctccgccaac acacttggca tttgtgaata tgtaatgacg taaaagtctg attctttcac 2025241 gcccctgtct ctcgtttgta aggaagaaac gagctgtgac tgaatatcgg atgccagacg 2025301 ccggctgttc tccccttcat aatcagattg aaaatacgtt tctgttcctg aagctgaagc 2025361 aacccctgaa ttcacatgaa tgctgacaaa aaggtcagcc tgattggcac ttgccttagc 2025421 cactctttcc tccaaggtca gaaaatgatc gtcagaccgg gatgcaacag gattggctcc 2025481 ctcctctttt agtttgtctg tcacatgctc tgagacagcc aaattaatat ccttttcaaa 2025541 gagcccgttt ccgaccgctc cactgtcttc accgccgtgt ccggcatcaa tatacactgt 2025601 tttcccttct atcggctctg ctgcctgtgc acaaggcgcg agcgtcaaag ccaatccgca 2025661 cagcgccaag ctcctccata acattctcaa cttactccct ccggtcacga gttctttcgc 2025721 agctgaatat cttccagctg taaagttcca ttatccttct ttgtatattt caccaggaca 2025781 tgtgtctgat ctggcagtga ttcacattca tcacgtttat ccttcggaac ttgtatcatg 2025841 gtttcttctc cattaagaga aaccgcaatc gtatgaggat cagccgagcc aatgtatttt 2025901 ccctcttcgg taaacctcgg cactgagtca tccgcacttg caacactgca ccccgaaaga 2025961 aagagcgcag taaacagcaa aagaaccgtt tgtttcacat gaccacctct tcctgatgtt 2026021 tggcttttat ctttgaccag aatggagaat ttgtaaagac aacgcgaatg caggcgagca 2026081 agttccatga ttttcaaaag ggctatacga cccgatcatt tcctgttgtt agaaagataa 2026141 cgagcagatt tgtctatgag gatggctcta attgaggcgc caattagaaa aaattagcgg 2026201 aaagaagcaa ctttttattc attttaaaaa atttgagaat agggtgagca aatcgtttga 2026261 cgggtgggtc agccaagcgt aaccttttaa aggatattta ctttattgaa agaagttaaa 2026321 gccatgaaaa aattcgttct gctgctggcg gcagctgtca tcacatgctc catcggccac 2026381 caaatcagtg gcggctacaa aggccccgaa aaagagcggc caaaacatca ctctgcactc 2026441 aagatattca gtcggtaaag cagatcaatt gcattaattt ttacatatag gctagaatat 2026501 gtgcgaatcc aaacgaaaga agatgatcaa atgaatccta agtataagcc actttttgaa 2026561 ccatttacgt ttaaaagcgg cgttacaatc aacaaccgga tcgcagtagc accgatgact 2026621 cattacgctt ctaatgaaga cggtacaata tctgaagcgg agctcgacta catcatcccc 2026681 cgttcaaaag agatgggaat ggtgattaca gcctgcgcaa atgttacacc ggacggaaaa 2026741 gcattccccg ggcagccggc catccatgac gattccaaca ttccaggttt aaaaaagtta 2026801 gcacaagcca ttcaggcaca aggcgctaaa gctgttgtac aaattcatca cggcggtatt 2026861 gagtgcccgt ctgagctcgt tcctcaacag gatgttgtgg ggccaagtga cgtgtttgat 2026921 aacggcaaac aaattgctcg cgcattaaca gaagaagaag tggaaaacat tgtgaaggcg 2026981 tttggagaag cgacaagacg cgccattgaa gccggctttg acggtgtcga aattcacggt 2027041 gcaaacggct acttaattca gcagttttat tctccgaaaa ccaaccagcg cacggatcgc 2027101 tggggaggaa gcgatgaaaa acgattagcc ttcccgctcg ctattgtcga tgaagtgaaa 2027161 aaagccgctt cagaacatgc gaagggtgca ttcttagtcg gctaccgcct gtctccggaa 2027221 gaacctgaga caccgggatt gacaatgact gaaacttata cgcttgttga tgctttaggg 2027281 gataaagaat tggattatct tcatatctca ctgatggacg tgaactcaaa agcgcgccgc 2027341 ggtgcagatc cgactcgcac acgcatggac ttattgaatg aacgtgtcgg aaacaaagtg 2027401 ccgctgatcg ccgtcggttc catccattcc gctgatgacg cgcttgccgt catcgaaaac 2027461 ggtattccac tggtcgctat gggacgcgaa attctagttg accctaactg gacggtaaaa 2027521 gtaaaagaag gccgtgaaaa gcaaatcgaa acagtgatca aaggcacaga taaagaaaaa 2027581 tatcatttgc ctgaaccgct atggcaagca attgtgaaca cacaaggctg ggtgccttat 2027641 aaagattaat gtgcaaagac tgccgaaacg attcggcagt cttttttccc tttatataaa 2027701 tagtttgtgt acacatctaa acagcaaaag aaagagctcc ccaccaactt cgaaaagaaa 2027761 atccaggaaa aacccctcac gctttcttgc ttttttcttt ttcattcgta cgtctccttt 2027821 ttacatgaat acgccttact tacgattttg caggagaaag gtttcatttt ataacggaca 2027881 catctagggt cgatcatgct tcgtgatcct ataagatgta tgaatggacc aagagtgcag 2027941 gtaataccgc catttgcttt ccttactttt caaacctatc ctttactata tgcggatact 2028001 taatattctt ctcccatact acaaatgtcc ccaaaacaaa acgcctccta tttatcagcg 2028061 caaactaata aataaaagac gtttgattta atgaccactt aataagctca tgtttaagaa 2028121 gccttatgct ctaacctcag cttatccgca accattgcaa tgaattcact gttggtaggt 2028181 ttagcttttg tcatgctgac agtataacca aacaacgagg aaatggaatc aatgtttcct 2028241 ctgctccatg ccacttcaat tgcatggcgg atcgctcttt ctacacggct tgcggttgtg 2028301 ttaaattttt tggcgatgtc cggatagagg acttttgtaa tgctgccgag caattcgatg 2028361 tcattgtata ccattgagat tgcttcgcgc agatagagat agcctttaat atgggctggg 2028421 acgccgattt catggataat gcttgtgatg ctcgcgtcga gatttttctt ctttggttca 2028481 ggctggctgc tgcgtataat actgctttgc gatgatggcg cacgatgcgt cacactgctg 2028541 gcatttccgc tgacctggcg gatatggccg acaaggtttt ccatatcaaa cggtttgaga 2028601 ataaagtagg acgcgcctaa atcgacggcc tttttcgtga catcttcctg cccaaaggct 2028661 gtcagcataa tgacattcgg ctgttttttc agatctgatt ccctcagcct ctctaaaacc 2028721 gcaagtccgt ctagatgcgg cataataata tctaatacga gcacatcggg atctttttct 2028781 ttaaacagcg acaggcattc ctgtccgtta taagcaacgc cgatcacttc catgtcttcc 2028841 tgtccttcta tatattcact taacaggctt accagctctc gattatcatc agcaacacaa 2028901 actttaattt tctccacgtt tcttcctccc caaatgtagt taacaggatt cacccttgct 2028961 acatgtttac attcgacaaa accgctatat accctctaaa aaaatcataa tcaccaatat 2029021 tagtggcata tctttgttat tctatgtttt tctctgtttt tcgactaaaa atgaaatttg 2029081 acaaacaagg aaacgtgaat ttgtcgaaaa atcttctttt gtatatttta ccgtatgtat 2029141 tctgagaagt gaagagggat caggatatac tgatgaacga atggatgtgc acgaaaaaaa 2029201 taagctgcgc ttctcgcgca gcttacccag ttgttttgac ttgatccgct tgttttaaaa 2029261 gttctttcgc atggcgtttc gttaagtcgg ttacttcgac acctgcaatc atgcgcccga 2029321 tttccgctac cttttcctgc ttagagagcg gcttgacacg tgtcgtcgtt ctgccgtctt 2029381 ttaactcctt cgcaatataa agatgcgtat cggccatggc agccacctga ggcaggtgtg 2029441 taatgcacag cacttgtgat cctattgaca ccttatggat cttctcagca attgcctgtg 2029501 cgaccctgcc gcttacaccg gtatcaacct cgtcaaaaat gatcgatgtc acatcctgtt 2029561 gtgaggaaaa aatgcttttt atggcaagca tcacccgtga cagctctcca cctgaagcga 2029621 ctttcgaaag ggatttcagc ggctcgcctg tattggttga aattaaaaac ttcaccaggt 2029681 caatcccttg ttcagtcagc tgaacgggct ggccgtttac aagcggcgcc tcttcattgc 2029741 gtgacgctgt tctgacctta aattccgtat caaaagttga tttttccatg tacaggcttt 2029801 ttaattcccg atgaatctca tcagccagct ttttcgccca tgtttttcgg atttgtgaca 2029861 catttgccgc ttccactgcg acatctttgc cgacggagtc aagctccttt ttcaagcttt 2029921 gaaggtggct gtccctgttt tcaatttggt caatctcttc ttcaatttta gaagcatatt 2029981 ccaaaatgtc ttcaacagtg gcaccgtatt ttcgtttcag ctgtttgatt tcattaagtc 2030041 gcgtctcaat atagttcagg cgttccggat caaattcaag ctcatccagc atatttctca 2030101 tctgaaatgt ggcatcctca agcaaatagt aggagttcga aacactttca gacatttttt 2030161 tcagcggttc gtttatatca gatatatctt caagctgcgc tgatgccatt ccaacccagt 2030221 ccaatccgcc ctgctcactg cgaagcgcgt tatatgcatt ttgcagcgac tcatatatct 2030281 tctcaaagtt tgaaatttgc tggcgctctt cttggagctg ttcatcttcg ttaagctcaa 2030341 gctttgccga ttcgatttct tcgagctgaa attgaataag atcaagacga tgggccattt 2030401 cctgttcgct ttcagaaagc tgcttaagct ttttgagcag cttcacatac cgctggtacc 2030461 cttcctgata cgttttgagc gcgctttcca cttcggcccc ggcaaacttg tccaaaagct 2030521 ggagatgatt ttcgtcttcc attaacagct ggttatcgtg ctgcccgtga atatctaata 2030581 aaagcctgcc gatctctctt agtgaagcaa tcgtgacaag cttgccattg acacggcaaa 2030641 cgcttttccc gctcgtgctg atatcccttc tcatgacgat catttcgtct gaaacgtcga 2030701 ttccctgctc agcgcatacg cctaaaacag gatggccgct ctccaacaga aacagccctt 2030761 caagttcggc ttttgcttcc ccatatctaa caaattcaga tgatccgcgg cctccgacta 2030821 aaagagaaat ggcatctatg atgatggatt tgccggctcc ggtttctcct gttaaaaccg 2030881 taagcccgcg ttcaaaagaa accgtcagtt cctcaataat ggcaaagttt ttaatcgata 2030941 gttcagctaa caaacagcat tacacctctt atctttgtta gattttctgt tacagcagtt 2031001 caaggagcct gttttttacg ccttctgtat cttcaggagt ccggcaaata attaaaatcg 2031061 tatcatctcc gcaaatggtc cccatcattt catcccagtc caaattgtcc atcagcgccc 2031121 cgattgcctg ggcattgccc ggcatcgttt tcagcacaat catatggctt gctgagtcta 2031181 ttttcacaaa tgcgtccatc aatgcccgct ttagctttga cagcggattg aaacgctggt 2031241 ccgccggaag actgtatttg taagaaccat tatttgtagg cacttttaca aggtgaagtt 2031301 ctttaatatc ccgtgatacc gtggcctgcg ttactttgta tccatcctgc tttagcatgt 2031361 cgaccaattc atcctgcgtt tcgatttcat tgcttgtaat gatctctctg attttaatat 2031421 gcctctggcc tttgttcatg taagcacctc tatttccaag cttatctgtt cttttatgtt 2031481 atatgattct ctgcacattg tacatgaatg cagaaaaaag gaataatagc gccctattat 2031541 tccggtacat ctgctttttt ttcttttaac gtcttatgtg cttcttctac aacgcgcatg 2031601 atctcttctt ccggcagttc ctggccttcc tgtccctctc ccggccaatg caaatgaagg 2031661 agaaactcaa tatttccgtc tcctcccgtg attggagaaa atgacaagcc tttacagata 2031721 tagccttcag cggcagaaaa actgatcatt cgcttgagca catcagcatg cactttagga 2031781 tctctaacaa tccctttttt gccgacggat tcccgtcccg cttcaaactg aggcttaact 2031841 aaagccatgc agtcgctgcc cggtacgagc aaagtcctta ggacaggcag gatgagccgc 2031901 agtgaaataa aggacacatc aattgtggca aactccggca tgccctttgt aaagtctgcc 2031961 ggtgttgcat aacgaaagtt cgtccgttcc atcacgacga cccgttcatc ctgtctaagc 2032021 ttccatgcaa gctgattata gcctacatcc acagcgtatg actgtttagc tccattttgc 2032081 aaagcgcagt ccgtaaaacc gccggtggag gagccaatat caatcataat tttatctttg 2032141 acagagacgg gaaattcctt caacgctttt tcgagcttta agccgcccct gctcacatac 2032201 ctcagcgggt ttcctttgac agttaacgga aggtcgcggt caattttttc tccaggcttg 2032261 tccaagcggt tttcgtttga atagacgatc cccgccataa tggctctttt ggctttttca 2032321 cgcgtttccg ccagccctct ttccactaat aatacatcta atcgttcttt ctttgacgtc 2032381 atgatccaat tcctttgtgt gtctttggtg gcatcagtaa tctaatacga tttgccacct 2032441 gctgttttgt cagtccaatt tcctcaagaa gcgctgttac acttccgtgt tcaataaacc 2032501 gatcaggtat acccattctg tcaatcggag tatgatattc accttgatca tgagcgaatt 2032561 ctaaaatcga gcttccgaaa ccgccttcta agaccgcttc ttcaattgtt aaaattggca 2032621 agccttcttt taggatactc ttcatcatct tttcatcaat cggcttaata aaacgcgcat 2032681 tcacaacgcg cacggaaagg ccttctttct gcagctcttc ggctgcttca atcgccattt 2032741 cgattgttgt gccgaatgtt aagatgacag catcgttccc tggacgcagc acctcccacg 2032801 taccgatcgg aatcgttttc aactgttcat ccatttttac gccgagtccg tttccgcgcg 2032861 gaaaacgcat tgctatcggg ccttcgtcat agctaagtgc tgtatgaacc atgtgctggc 2032921 cttcattttc gtctttcggc atcattaaga ccatgtttgg aatgtggcgc ataaacgcaa 2032981 tatcaaacac gccttgatgt gtctctccat cagcgccaac gagtccagca cggtcaattc 2033041 caataaacac attagcgttt tggcggcaga tgtcatgaac aacttggtca tatgcccttt 2033101 gcaggaaggt tgagtaaatc gccaaaaacg gcttcatacc ctgcattgcc atagctgcag 2033161 ccattgttgc ggcatgctgt tctgcgattc ctacgtcgaa catccggtca gggaattcct 2033221 ttgcgaagcc ttcaagcttt gaaccgacag gcatagccgg cgtaatggct acaatgcgtc 2033281 cgtcctcgcg cgccattcgc tgcacagttc cgctgacaag accgctccac gaaggagctg 2033341 cggctttcgg ctttacaaag tcaccggtat taattttata tggtccggta ccatgccatg 2033401 tcccaatcgt atcggtctca gccggtttgt accccttccc ttttttcgta atgacgtgca 2033461 gaagaacagg gcctttcgtt tttttggcgt attgaagatt ctcaatcagc tcatgataag 2033521 aatgtccgtc cactgggccc aaatacgtaa aaccgagctc ctcgaaaaac attccggaga 2033581 cgagcatgta tttcaggctg tctttgaccc gttccgccgt ggcggcaagc ttgcccccaa 2033641 ctgccggaat ctttttaaat aagtattcaa gctcatcttt gacccactgg tatttccccg 2033701 cagtgcggag ccgtccgagc atagagtgaa tggcaccgac gtttggcgca atactcattt 2033761 cattatcatt aaggatgaca atcatgtctt ttttctcgtc gccgatgtgg ttaagggctt 2033821 cgagcgccat accgccggtc agcgcgccgt caccaatgat cggaataata tattcatccg 2033881 ttcctttaat atcacgggca gctgccattc ccatcgcgcc tgacagagaa gtcgagctgt 2033941 gcccggtttc ccaaacatcg tgctcgcttt cactccgctt tggaaatccg caaagccctt 2034001 tgtactggcg aagcgtcgca aattcttttc cgcgtcctgt cagcagctta tggacatacg 2034061 actgatggcc tacatcccat aaaaatttgt ctttcgggct gttaaattcc ttatgcaggg 2034121 caacagtaag ctctacgaca cctaagtttg ggccgatgtg gccgccggaa gcggataaac 2034181 ttgtaattaa aaactgacgg atttcatcac ttaatttctc taattcatca atggacatgt 2034241 tttttaaaaa cgacgggtcc tgtattgata aaagatccaa agcggatcaa ctcactttca 2034301 gcatgaattt ctgcaatgat acatgtcttt tgcatgccga gctgacaata atctcagaca 2034361 taaaaaaaga caaacgcgct tttccttttc atttttcata taaactgctt acattttacc 2034421 atacctcgtg cagccgcttc aaattaggat cgttttagtg atctcttgcc gcaattaaat 2034481 cacaaagctc atataaaagg tctttttgaa gagagagtcc gccgatcaat cgcttcgcct 2034541 cttttatatg aacatccaat ttatgtttgg ccccttccaa tgaaagaagc gacgggtatg 2034601 tcgatttgtc atttgtggta tccgagccga cacgtttgcc gattttctct tcactgcctt 2034661 ctaaatctaa aatatcgtct ctgatttgaa atccgattcc aatgtggctg ctgaaggtac 2034721 gcagtgtttc aatgtcttcc tcaggcgcat cagccaaaat agcaccggcg attacacaaa 2034781 agccaaggag cttggcagtt ttccgttcat gaatggattc gagctcttca agcgtgactt 2034841 gtcggttttc cgcttccata tcagctactt gcccaccgac catgccttcg gtgcctgccg 2034901 ctgaaatcag ttcattcaca agccgcaggc gcttttctgc tgacacctcg tctgacacgt 2034961 gggaggtaat cagcttaaag ctttctgtga gcagcccgtc acccgctaat actgccgtcg 2035021 cttcaccaaa cactttatgg tttgtcggct tcccgcggcg caaatcgtca tcatccatgc 2035081 atggaagatc atcatgaatt aacgaatacg tgtgaatcat ttcgacagca cagcccaccg 2035141 gaatgccgtc tttttcgctt tttccatatg catttaaaac agccagtaca atcagaggcc 2035201 gcaaccgctt tccgccggcc tgtagagaat atagcataga tttctttaat gagtccggca 2035261 tatcaagctt ttctgtatag acagaaagct gattttcaat tgtttttttc cggtccgcca 2035321 gaaagctcgt taatttattt gtcaccttcg tcttcctcct gaacactgaa aggtgccagt 2035381 tcgccgtctt cttttaaaat gaagtccatt tgcttttcga ctttttgcag cttttcatgg 2035441 cacatttttg acagagccat gccttcttgg aaatagttaa tggcttgctc tagaggcaca 2035501 tctccctctt caagctttga tacaatgctc tcaagccctt tcatcgcttc ttcaaatgtc 2035561 atgttttcat tttttttcac gtctgtcatt tttcttcccc tctcttttct aatacttcac 2035621 aggtcagcac gccatccttc agcttgattt caagccggtc ctgctcttct atttgactga 2035681 cacttttaat gagtttatct tctttataag ccaagctgta tcctctttcc atcacttgaa 2035741 gaggacttag tgcattcagc ttgccaagaa cggtttgaaa ttgggaatgc agctgcttca 2035801 tttggatatt catatttttt ctcagctgat ttgtttgttc ctggtatcgt gttctcgctt 2035861 gtttcagctg ttcatgagga tgcaatgcct ctaatctgta cgtttcacgc tccagctgtc 2035921 tgcttttccg atctaaaaga gcggtcagct gtgcttgaaa ctgctggtac gcgaggtcaa 2035981 actgctgctc tttttgcgca tacaaacgct ttggaaaacg aaaggcatag gacgattgca 2036041 gcgtttgtat ccgttctttt ttctggccga gatgctgctg cattgctctt gtcattctga 2036101 cttccgctgt ttttgtccgt tcgattaaat cagtggtatg aggcacagca atctcagctg 2036161 ctcctgtcgg cgtcgcagct ctgatatcgg cgacaaaatc actaatcgta aaatccgtct 2036221 catgtccgac tgccgatata atcggaatat tggaagcaaa gatggcgcgt gctacaattt 2036281 cttcattgaa tgcccacagt tcttctatcg aaccgccgcc tctcccgaca attaatacgt 2036341 cgcaaatctc tttttcattt gcctcttcaa tgcgcgtaac gatggatctg ctcgcatttt 2036401 caccttgtac gagcgctgga agaacaatga cttttacaag gggatatctt ctttttagag 2036461 ttgtaataac gtctctgaca gcggcacccg ttggagatgt cacaaccccg attgtggctg 2036521 gaaatgcggg gatttgtttt ttgtagcggt cgtcaaataa accttctccg gcaagcttct 2036581 tttttaattc ttcgtacgct aaataaagcg ctccaacccc gtcaggctgc atttctttgg 2036641 catataattg atagtttccg ctcggttcat atacggaaat tccgcctctg accagcactt 2036701 tcattccgtt ttcaggttta aaaggcagac gctcgctttg tctcgcgaac atcaccgact 2036761 gcattcttgc gttttcgtct tttaaagtga aataaatatg ccctcgtgtg tgtatcttta 2036821 cattcgacaa ttcgccttta atccaaatat tttcaaggtg aggatctaca tcgaattttc 2036881 gttttatata ctttgtcagc gctgagacgg tcacatacgc tgcttcaccc atgtctaaaa 2036941 actcctctcc taagcattcc tgcaccataa ctaaagaaaa cccgccctgg ctttaggagc 2037001 ctgaagaagc gggtatcgtg ctcatattca aggcgggtaa acatttcgcc tgtgaatatc 2037061 tccaattatc tatgataacg tacgtttcgc agatttaaca gtattatgcg caagcatcgt 2037121 gatggtcatc ggacctactc cgcccggaac cggcgttatg aaggacgctt tttcctttgc 2037181 cccttcaaat tcaacgtctc cgcaaagctt tccgttttcc agacggttaa cgccgacgtc 2037241 aatgacaaca gcgccctctt tgatctggtc tgcactgatg aagttggctc tgccgactgc 2037301 caccaccagg atgtccgctt ttttcgtatg ttcagtaata ttttctgttc ttgaatgaca 2037361 gtaagtaacc gtcgcgtttt catttaataa aagctggccg acaggtttgc cgacaatgtt 2037421 gcttcggccg actacaacaa cctctttacc ggaaaggtca atattggttt tcttcaaaag 2037481 ctcaacaatt ccatgaggcg tgcaaggaag aaacgtatct tcgccaagca gcattttccc 2037541 tacgtttaac ggatgaaaac cgtctacatc tttatcaggg gagatacgtt cgatcaccgc 2037601 tttttcagaa atatggtctg ggagcggaag ctgaacgaga atgccatgaa actcagggtc 2037661 ttggttatat tgatcaataa tggaaagcag ttcagcttct gtgaggctgc tgtcaaattg 2037721 atcgagcttg aaattcattc ccattgtttc tgccgctttt ttctttcctc gcacgtaaga 2037781 gtgagaagca ggatcatctc caatcaaaat aaccgccagt ccgggagtga cgccttgctt 2037841 tttaagctct tctacctctt ttgccaattg ttcgcgtttt tctctagccg tttcttttcc 2037901 gtcgatgatt gttgcagtca ttttctttcc tcctatgatt gttcaatatc agatttaatg 2037961 ttagaaagaa ccccgtttac aaactttgtc gctttgtcat caccaaaccg ttttgccagc 2038021 tcaatcgctt cgttcatgga gacattcacc ggaatgtctt cggcatatgc catttcatat 2038081 gctgccaggc gcaaaatcgc acggtcaaca ttggcaatcc gatcgagctt ccaattcacc 2038141 agatgcttgg agatcatttc atccagctgg tcttggtgtt ccaatacccc gtgtacaagc 2038201 tgttcaaaga aaggatctgt tttttcttca tccagtgcgt gttctatggc ttcattcact 2038261 gcaatatcgc tgacatcaat ttgaaatagt gcctgcaaag ctttttctct tgctgttctt 2038321 cttttcattt tctttctcct ttgatcctct ttatccgctt gtcgttaagc cacaaagaga 2038381 tcataacata tttttttcgt atccgcatat tgaaatcaag gtttttttac cctattaccg 2038441 aatattttca cacaccttaa tatgattatt cggatttcac gttcatgaag aaactcggct 2038501 atgtaagccg gctttcttca tgctttgaaa taaagggtaa cgtgtaaaaa aaccaaaggg 2038561 ccgccctccc cttggtttcg tgttaagcca tttacatttc ttcgtcgatt tggacttctt 2038621 gggcttttgt gtcaaattga atgccgacga tgtgaatatt gatctcgtta atcgaaagag 2038681 acgtcatatt taataaggtt tgacgaatgt tttcctgaac ggatgctgca actttcggaa 2038741 tcgaaacgcc aaatgtaacg acacagtata catcgatcgt aattccgtca tccgccaggt 2038801 cgactttgac acctttgcca tgattcactt tgccaaagcg ctcaacgacg cctgtcgcaa 2038861 agtttccgcg catttcggca actccatcaa cttctgatgc tgcaatgccg gcaatgacct 2038921 caatgacctc cggtgcaatc tcaaccttac ccaaatgcgt atcttcgtga tccattttaa 2038981 gcaagctgtt gtctttcatt caattcacct ccgtaaaaat tatgagccca ttacatcata 2039041 tgtttctaaa aatttcgtat taaactctcc gctcacaaat gtttcgtgtt caagcagttt 2039101 taaatggaaa gggattgttg tctcaatgcc ttcgatgacg aattcgctca atgcgcgctt 2039161 catgcgggca atcgcttcat ctctcgtttt tccgtatgtg attacctttg caatcatgct 2039221 gtcatagtac ggtgggatgg aatagccagg gtacgcagct gaatcgacac ggacaccaag 2039281 accgccagga ggcaggtaca ttttaatttc accaggtgac ggcatgaaat ttttgcttgg 2039341 gttttctgcg ttgattcggc attcgatggc ccagccttca aattcaacat cttcttgctt 2039401 gaggctcagt tccattcctg aagccacttt gatttgttcc ttgatcaggt cagttcccgt 2039461 caccatttct gtgactgggt gctccacctg gattctcgtg ttcatttcca tgaagtaata 2039521 gcgctgttca ttgtagtcat agataaattc aactgttcca gcacctgtat agccaaccgc 2039581 tttggcagcc tttaccgctg catctcccat ttgctccctg atttctgaat caagggcagg 2039641 agatggtgat tcttccaaaa gcttttgcag gcgtctttgg atcgagcagt cgcgttcgcc 2039701 caaatggatc gtatttccgt agttatcagc aagcacttgg atctcaacgt ggcgaaaatc 2039761 ttctatgtat ttttcgatgt atacacctgg attcccaaat gcagttgccg cttcctgctg 2039821 tgtaatctta atgccattaa tcagttcctc ttcagtgcgg gcaaccctaa ttccttttcc 2039881 gcctccgcct gcggtggctt ttataattac aggataccca atttcattag caagcgaaac 2039941 cgcttcttcc acattttcta taattccctg tgaacccggt acgattggca cgccggcctg 2040001 tttcatcgtt tcccgcgcaa cgtcttttgt tcccattttt gaaatggcgt cagcgctcgg 2040061 gccgacaaac gtgacattca cttcttcaca taattcagcg aaatcagcat tttcagctaa 2040121 aaatccgtat cccggatgaa tggcgtccgt gccagtcagc tttgcaacac tcacaatatt 2040181 tgtaacgttt aaatagctgt cttttgatgc tttcggtccg atacaaaaag cttcatcggc 2040241 catttgaaca tgaagggcat ctttatcagc ttctgaataa acagcgacag tctcaattcc 2040301 gagctctctg caggctctga tgattctgac agcaatttct cctctgttgg cgatcaatag 2040361 ctttttaatc atgttcagtc tccttactcc gcttttacaa gaaatagagg ttgtccgtat 2040421 tcgaccagct ggccgttttc tactaatact tcaacgattt cgcctttcac ttctgcttcg 2040481 atttcgttga aaagcttcat cgcttctaca atgcagacaa ctgtgttttc atttactttt 2040541 gaaccggctg ttacatacgg gccagcttcc ggtgatgaag aagcataaaa tgttcctacc 2040601 attggtgaag tgattttatg cagattctca tcttgctttg gtgcttcttg ggcaggtgcc 2040661 gctgcttgct gcgcttgcgg ctgaactgcc tgcggagcct gtgcttgtac aggtgctgcc 2040721 ggtgcctgct gcatgacttg aaccgtgcct gcttcgtgtt ttttcagttt taaggataca 2040781 ccttcatttt catatacgaa ttcgtcaatt gtagactcgt caattgcttt aatcagctcg 2040841 tggatttctt tgatatttaa cattcaatcg cactcctatg tatgaaattt ctttttttat 2040901 aggttactac taaaagtaca tactatgttc atcttacagg agcggacttt tgaattcaac 2040961 tctaatatga cagcaacgca aaaagcccgc ttgtttagcg ggcttttttc cctcattctt 2041021 atttagaggg ttcaaatgtg acagcgacat ctttcattgt tttgatttct tttgccacaa 2041081 ggtctataat ggctgtcgcc ttcgatttag agtgtttgtc tgatttgact gtaatattga 2041141 ttttatctcc ttcagcatta acaagcgcat cctcgtaacc ttgtgtttta atcagcgttt 2041201 ccagctgttt ttctgttcct tccacttcac tgagagccgt cattttatcg tatgcttcgc 2041261 ttttctcctt ggctgttgca tcatcgcttg acacaatggc attcagctct tctctttctt 2041321 tgcttctggc atcttctaaa tcaagacggt acgttgtaaa caaatcatca tcggctgttt 2041381 ccgtaacaac agttcctttt tcactggctt cagcggatgt ttccttgtct gctgatgaat 2041441 ctttcgttcc ctttgttcca tcttcttttc ctttttcagt ttctgtaccg cttttttcct 2041501 tcgtgtcttg cttggcaggc gctttttcag ttgcgacctc tccgctgtca gacgcgcttt 2041561 tttcactttg catctgcacg gcgtttttgc tttccggcga catgatatag tagacgctta 2041621 acaccacgac aagactgagc attgttaata gccaaacggt ttgtttttta agcatttatg 2041681 aatcctcctt tattttttta ggggcaaccg caacccggtg gcttggaaca tccaggaccc 2041741 gtgtcaccgc ttcgataatg gtttgtttta tttgaacgtt gtccactcct tgagcaacaa 2041801 cgagtacacc gcgtatatca ggttttttcg tttggacgac gacaggtgtt tctttatcgc 2041861 cgtttttgat catgacgatt tcttcctccg atgattggtc tgtaacgctt ctttttccgc 2041921 cttctttgtc agtttcttca gtggttgtat ttttgtttga tttgtttttt tcgtatactt 2041981 tcagcgacgt tgcatctaca ttcacgacaa ccgagacatc gtccacacca atgattgttt 2042041 caagaatttc tttcagttga ttttcgtatt ctttttcata gtcatcgatc gagtctttag 2042101 gtttatcaga ttttgaggct ttaaacactt cggctgtttt ctctttgctg tctgcggaat 2042161 gttgtgatga tacggccgtt atcgttttgg cgttttcagt tttctcaggt gaagaaaaca 2042221 gctggctgac aagcataaag gaaactccga gaacaaaaac gaatagaaag taatgatatt 2042281 tggtcagctt cggcttttcg ccgtccttcg tttgtcccgg aagaaactgc tttttcaata 2042341 cattccataa tccgttttta ttcattgccg acactctccc cgccttccat atgaaccgta 2042401 attttctcac ttccgatttc ccaaatgtcc gcgagctgcg tttgtatctg tttggcttct 2042461 ttttgttcgg ctgcttcttt tgttacgtat gcatgatctg tatcaatgtg gaccggcgcg 2042521 accgtttgga ccgttttttc agaagacggg gccatataca cgctgattgt tttaatatcc 2042581 tcttctgaat ctaccttttc tcctgccgtg agtttgatgc ggcctacttt atattcatca 2042641 tgactgaatc tctcctccgc tttctttttt agttggacag ccatttcttc tagaatatat 2042701 gcgcgctggg aagcttgtat ttctattttt tttgaattga tttgattttt tatgtcggca 2042761 gactctgact gcccgttttt tgtgaggtat tcaaagatga cttcggggtc tgtcttgaaa 2042821 agtttaaaaa tcggcgtaag catgacgaca atcaagagca ggctgactac catttttgcg 2042881 tacttttgca tgctggagct cggcagcagc atatcaatca caattgcaaa taggataaac 2042941 aacacgatgg tggtaagcca ttccgttaaa aaactcattt gcctgcctcc ttcatttcat 2043001 catcatcgtg aggtttccgg ctgtgattat gacagtaagg cttaaaaaaa acatgagaga 2043061 cacaatggcg agagctgcaa aaatataaat gacgcttttg ctgatgacgt cgaggcaggt 2043121 gatgacgggc ccgcctccta gcggctgaag aatcgcggct gccagcttat aaataaaagc 2043181 gagggaaagc actttgattg ccggaaatgc cgcaatacag atcaaaatag cgacaccgag 2043241 aatccctacc gtatttttca gcagtaaaga ggcgctgatt actgtatctg ttgcgtctgt 2043301 aaacattcgg ccaagcacag gaataaaatt tccggttata aatttagccg tcctgagcgt 2043361 aatgccgtct gtcactgcag ctgacgctcc ctgaacagag atgacgccga gaaagatggt 2043421 aagaaaaaca gccagtgctc cgatggcgat atttctgagc aggttagcca gctgcgttac 2043481 tttgtattgt tcagtcatcg tgctgacaat gctcagaatc gctgataaaa aaatcagcgg 2043541 catgacgata ttctgaatca agagaccgct cgtgttcatc aggaagagga taacaggatg 2043601 aaagaaggca gcagatacag ctccgcctga ggaagccaaa agcgccaaga ggagcggaat 2043661 gagcgccagg ataaagctgg tcatcgtctg aatcgcctca gttgcatagt taattgccac 2043721 atgaaagcta ttaagcgcaa ggataatcag caccatgtac acaattgagt aagcgacctt 2043781 actgacggtg ctttgctgaa aagcattttg caaaagctgc agaatgacgc aaaaaatcgt 2043841 gagcaaaatc aatgtgccca gcagctttcc gttggcaagc acttcatgaa acaaataaga 2043901 aaagagagct ttcagccatt cttgcggtga gaatgattta tcgccattga taaactccat 2043961 taagctgcct ttttggcttt ccggcagcag tccgccgtat tctgtcataa tgtcattcca 2044021 aaattccccg atcttatctg tttcaagcga ggctgctgtc ctttccgcta attgctcggc 2044081 tgtttcagca tggtcttccg tttgttctgc attaccagct gcttgtacaa tttctgcacg 2044141 gcctgctatg atcagcacgg ccaaaagcaa aacccattga aagcgcttca atctaccgcc 2044201 tcctttcggt tatgacatag aaggtataag tccgagaatc gtttcgataa tgacggttaa 2044261 aataggcaca gccattacga gtattaaaat tttccccgcc aattctattt tcgaggcgat 2044321 ggctccttga ccggcatctt ttgtgagctg tgccccgaat tcagcaatat aggcgattcc 2044381 gataatcttt aaaatggttt caacatagac catgttgaca tttgcattaa tcgcaatttt 2044441 ttctatcatt cgaataatgt cgtagatttg gtctaccaaa taaagaaaaa tggcacatcc 2044501 ggcaaaaacg acgattaaaa acgcaaaagt cggcttttgt tcttttacaa ttaaagaaag 2044561 gaaggtggcg atcagcccta aacctacaat ttgaacaatg tcaatctgca agccccccta 2044621 tccttggaat aaaaacacag cttttatctt tttaaatagg tcatctacaa tcgtggcgac 2044681 cataaataaa atatagataa aacctaacag cgtcacccac tgagcatatt ctttcttgcc 2044741 catctgatcc aatatcgtgt gtaaaaaagc gaccacgatt cccactccgg cgatttgaaa 2044801 tatgacattc acgtctactc ccattttatt tttgctcccc tcacgtttac atcaatagaa 2044861 gaatgagtaa caagcccgct aaaaagccca aactttttat catcttttcg tttttcgctt 2044921 gcgcctgctc agcatccgct tctgaggctt ccaaatgtgt cagcgccagc ttgatgtgct 2044981 tttgctgaga gattcgatca tgaatcccaa gcgtctcgcc aaactgcttc agcacttcgt 2045041 attcgctttt tttcaaagac agggtgtccc ataccttctt taagctttgc tcccacgccg 2045101 ttttcgcgga atcacttccc ttgtccagct gatcactgaa tgcggaaaaa agagttgaaa 2045161 caggctgtgc gagctgtttg gcaatctgct gtgaagcagt atgaagcggt gtatggccgt 2045221 acatgatttc agcctcgagg gattgaagcg ccgcacgcag ctggcggatt tgccgcggcc 2045281 gttctgtata aatcttcgcc atctcaaaac ctgtccatgt tgtcgctacc acaatgaata 2045341 cagcgcccag cagcttcagc atgttttcac gcccgtcgtc ctagacagca catttccgtc 2045401 tttgtcataa atttggctca ctgtgcccgg cccttttgct cttgataatt ccaaatagcg 2045461 gtcaaaggct ctttcttccc acaaacgctt caatgaaggc cgcttcatca ggtcggatat 2045521 actccagcca tgcgccgata cgattactga aacaccggca tgcagcgcct ccagaagtgc 2045581 atctgtatct tccatacgcc cgatttcatc gacaatcatc acctcagggc tcatggatcg 2045641 aatcatcatc atcagccctt cagcttttgg acaggcgtct aacacgtcaa ttctctgacc 2045701 aaattgatgc tgcggaatac cgcgaagaca tccggcaatc tctgaccgtt catcgacgat 2045761 ccctgtcttt acgggcagca tgtttttttt gccggtgctt gagagcctcg caaggtcccg 2045821 gagaagtgtt gttttgccgg tttggggcgg tccgataatc agcgtattca gccagctgtt 2045881 ttgatataag tatggaagca gcggctccgc aatccccagc ttttgccggg caattcgtat 2045941 attaaaagat gcgatgtcac ggaggccttt cacacctccg ttttccgtaa tgactctgcc 2046001 cgccagtccg actctgtggc cgcctctgat cgtgacatac cctttcttca gctcttcttc 2046061 aagtgtatac atactatagt tgctgagccg gctcaggatc agatgggcat cctcggccgt 2046121 gcccgcatag gacaaataaa caggttgtcc tcttcgaatc aattcaacag ggcggttgat 2046181 ccgaattctg acttcttcga tttccagcca ttgttgttcc ggtatttcag aaagggcgtt 2046241 tttcatggat tcagggagaa cctcagcgat ttcattcaac agagcctcct cctttctacc 2046301 gattggcttc tttaaaatgt atgatgtgag gcagacttta tgacaagcct ctctttattt 2046361 atgaacaccc gccaaaatca agacaacacc cgtaaaaatc agaatcagct ttgcatacga 2046421 aagctgcccg gcaatttggt agattccgac agtcattgta atgataaaaa tcaacggacc 2046481 gacaatagcg agaatgctgt taaccacaac cgccttccgg acatcgttgg tcacaagcat 2046541 gacaattgct gccgtcagct caatcataga ggataaaact cgtaatcccg ccattgttaa 2046601 aacagtagaa ttgatatttc caagtaaaaa tttcatagca ctctcccaac ctcccatttt 2046661 tttatatgat atgctctagc ttgctgaagt agtcttgtca ttttcgtata aaagaaagat 2046721 tctgtttttg ggcacaaaaa aagcctgctc ccatttggga acagacttct ttttttcttt 2046781 ctatgctctt gaaacgtaag aaccgtctga tgtattgaca acaagtgtgt cgccttcatt 2046841 cacaaagaac ggcacgttta caacaagccc ggtttcagtt ttcgcaggtt ttgtaccgcc 2046901 tgacgctgta tcacctttaa taccaggttc agtttcaaca actttcagct caactgtgtt 2046961 tggaagttcg ataccaagtg tttcatcctg gtacatcatg atatgcacag acatgttttc 2047021 tagcaggtat tttaattctt cttcgatttg agttgcgctc agttcaagct gctcataaga 2047081 agaagtatcc ataaatacgt gctgatctcc gtttgcatat agatattgca ttgttttggt 2047141 ttcgatttgc gctttcgcta ctttttcacc agcgcggaat gttttttcct gaatcgcgcc 2047201 agtgcgaagg ttgcggagtt tagagcggac aaatgccgca ccttttccag gttttacgtg 2047261 ctggaagtca acgacgcgcc aaatgccgcc atctacttca attgttaatc ctgtacggaa 2047321 atcgttaact gaaatcatgt ttaatgtcct cctatattcc aatcacaaaa taataagttc 2047381 ttttggggaa tgggtgattg tccggttgcc gttttctgta atcacgatgt catcttcaat 2047441 gcggacaccg cctgtttctg gtatgtaaat gcccggctcc actgtgacca ccatacccgg 2047501 ttcaaggata gctgaagatc tgacggataa tcccggcgat tcatgaactt ccatgccgag 2047561 cccgtgcccg gttgaatggc cgaaatagtc accgtagcct tttgcagcaa tatgatccct 2047621 tgtgagggcg tcagcctctt ttcctgtcat tcccggctta atatgtgcga cgccaagcgc 2047681 ctgagcatca aatacaacct gatagatctc cttcaattga tcactgggct gacctacagc 2047741 gaccgtccgg gtaatatcag aacaatatcc tttataataa gcgccaaaat caagcgtaac 2047801 aaggtctccg ctttcaatca gtttgtcact ggccacaccg tgcggaaggc ttgaacgaag 2047861 gcctgaggcg acaatcatat caaaagaaga gctgtctgct ccctggcttc tcatataaaa 2047921 ctccagctca ttggcaacag cgatttcaga aatgccgggt ttcataaacg tcaagatatg 2047981 tctgaaggca tcatctgcaa tcttcgcagc ttcctctaat atcttaatct cttcactaga 2048041 cttaatcaag cgcaactttt ccacggattc agccacaggc actaattcgg catcactgat 2048101 aacggcgctg tatgaagcgt aagtgccata tgtcatgctg ttctgttcaa agccgagacg 2048161 cttgatgcca aacgattcaa cagtgtcggc agtggtctga atcaagctgc cgccatgttc 2048221 aatgatctca aaacccttta cctgaacctt cgcctgctca gtataacgaa aatccgtaat 2048281 aaacgctgct ttgtcacccg atataacagc caaacccgcc gaacctgtaa accctgtcat 2048341 atagcgtaca ttagtgttgc ttgtaatcag catgccgtca attcccagct gtccaaacag 2048401 gtttcttaat ttctctagct tcatcttgat tctccccctt gctggcttaa taagtagcga 2048461 acagcaagct tgtagccttc agctccaaga ccgacaatct gccctttcgc aacaggagcg 2048521 ataaccgact gatgcctgaa ttcttccctg gcgtataagt ttgataaatg cacctctacc 2048581 acaggaagac tgatgcttga aacagcatcc ctgatcgcat agctgtaatg actcagggcg 2048641 ccggggttca gaacaatccc gctgtattgc tcctcagcct catgtatcgc atctatcaaa 2048701 tcaccttcgt gattagactg gaagaaagtg agctggatat gtaaggcttc agcaaactga 2048761 aaaagatctg tttcaatatc ggtcagtgtc tggcggccga atacttcagg ctcacgactc 2048821 ccaagccggt taacattcgg tccgttcaaa atcaaaaaat gaggcacaca atctctcctt 2048881 ttcgcgaggg tttctcatgt aaaaaatgtt cacttctcgt gaacatttta tcatactgga 2048941 aaaggattat acactattct ctatgcattc ccagcgcacg tgcaagcttt tccgaattca 2049001 gctcattgta ttcaaatgaa atagaatacc cgacaaacag cccgtaaagc aaataaatgc 2049061 aaatggtcgt aataattgta tctgatgtca gttcggtcac cgtgcgcaca tctggaaaaa 2049121 tcggattaaa aacaaaaaac acgagcagcc aaagcaccaa gccgtataaa atacccggcc 2049181 acattgtttt taaacgtttc aatagaagaa aataaagaaa tgctgcgcca attgaaatta 2049241 ctccaatcaa aatgatgctg attaccgttc ccagcccatg ttttttccac tctccgagta 2049301 caaacggctg caatatcata ttcgggctga tttcggaaaa atgaaacaaa tatgcgatat 2049361 aagcaacgaa actccaaagt acgcctccgc aaaaacctgt tgccgccacc ctgccggcca 2049421 ttgaaacagg cggcttttgc ttctcattca attcttcatt ttgttctgta tctttttcgc 2049481 ttgtcatcat ggcacctcca gttaaagtgt gcccaaaaaa tgaaatgtca ataaaaaagc 2049541 tcacactttt tggcagctgc gagtaaaatt tgaaaataac gggtataatg catgtagaaa 2049601 aagcaaggct atggcaattt tttcagcctg tcaatctaga ggtttagcgc tgtttcctgt 2049661 acaatagagt gaaaggaaat ggttagcaat cctaaagaaa taggcaggtt gataatatgt 2049721 caaaacataa agttccgccc gcttacggcg ggcaggctgt tgtggaaggc gttatgtttg 2049781 gcggaaagca tcattacgtt acagccatca gaagaacgga tggaagcatt gactttttta 2049841 agcttccacg caaacacaac ccgaaactga acatcgtgaa aaagataccg tttttacggg 2049901 ggatcgcggc cattatcgaa gcgagtgcaa acggcacaaa gcatttgaat ttttcaagcg 2049961 aacgttacgg gctcgatcca tctgaagacg agacacttga gcaggaagaa aaaaaatcct 2050021 ctgggctgtc tatgtatctc agcctcgcag ttataggcgt cctatcattt ttgttcagta 2050081 aattcgtatt tacattggtt ccagttttct tagcggaact gacaaggccg attttttcct 2050141 tgaacacagc gcaaatcgcg attgaaagcc tgtttaagtt gattttgctg ctcggttaca 2050201 tctatttttt gtccatgaca ccgcttatta aaagagtgtt tcaatatcat ggagccgaac 2050261 ataaagtcat aaactgttat gaacagaatt tgccaattac tgtggagaat gtccaaaacc 2050321 aatctcggct tcattaccgc tgcggatcaa gctttatttt atttacgatt attgtcggca 2050381 tgtttgttta tttactcgtt ccgacagatc cgctttggct gcgtgttata gatcgtgtcg 2050441 cactgatacc ggtcgtgctt ggtatatcct ttgaagttct gcagctgaca aacaaagtgc 2050501 gtgacattcc cggtctgaaa ttacttgggt acccgggact ttggcttcag ctgttaacca 2050561 caaaggaacc taaggatgaa caggttgaag ttgccatcga aagctttaac gaacttctca 2050621 gactcgaagc attgtctgag caaaatcaga agccttctca caacgtcatc taaaatccgt 2050681 tgccctgcta ttactttcgg aggtggacag ttatgaatca tcgtgtacaa cctattattg 2050741 ctgtattaat tgcgctggga gcgttcggtt tcctctatgt gctggtaacc aatcccggag 2050801 aaatggcaaa aatggcggta accgtcatcg tggcaggtat cattatttat tttattgtga 2050861 aatatgtaat gaatcgaaat gcgggcagcg aaggagcagc cttcaaaaaa gcggcgaaac 2050921 aatcacggcg ccggatgaaa gaacaaaaag caaaacaccg cgccggacat aagggacgtg 2050981 tcagccacct gcgaagcgtt ccgagcgcca gcaagcctaa gccgatgatt ctcaagaaaa 2051041 aaagccagac tcagctgact gttatagaag ggaaaaaaaa taaaaagaaa aacagagcgc 2051101 ttttttaata ggtccactgc tttaaaaaca gctctgtccg tcttttacct agctcaatca 2051161 gggctagttt tttttgttgt gttaaatgaa aatcagtggc cattacgtca tcaacaggga 2051221 gaaaaatgat attttgttca tagcgtgacg caatgtgcct tgcgtcatga gcatccttca 2051281 tcgtttcaaa cagggcgccg aacagttcaa aagcgttgcg gatatttttt ttcggacgct 2051341 ctctttcacg cggcgcaagc gtgacaccga tcacagggcg ctttctttcc tttgaaaaca 2051401 gccagattgg aaaattgctt aacacgcctc cgtcgacaac cgtggcggtg cctgtgtccg 2051461 tttttaattt tatcggttca aagaaatacg gaatgctgca gctcattctg accgctctgg 2051521 caaccgggaa catatctgga tttaacccgt aacgggccaa atcgtccggc aaaacaatca 2051581 tggtgccgtt tgtcagatca gaagcaataa ggcgcagaga ccctttctgc aaatcgccga 2051641 aaacccttat gcctttcgct cttaacagat cagcaatcca tttttctatc gtatcgcctt 2051701 tgtataagcc aagacgccag tagatggaca cccactggag catctttaag gggagaaatg 2051761 agtacctctg atccagcaat ttctctccgt ccacttcttc aattaaagcg tggatttcct 2051821 tactggtgta acctgacgca atgaaagcgg caataatggc gccggcgctt gtacccgcaa 2051881 ctcttttaaa gcggaagcct ttttcctcaa gcacttcata agcgcctgcg agcgcaatgc 2051941 cttttactcc tccgccggaa aacacaccgt caatatacat ctcattccct ccccctccat 2052001 ccgatcgttt attaccattt taagaaaaca cgcgaagaaa tagaccaacg aatgacgggt 2052061 ggcgtcagcg tatcaaaaaa gacggcctcc ttcgagaccg cctttttact gattatgatg 2052121 ttctgttttc ttttggattg atttcagatc ttttttacgg gcatcatctt cttcaaaata 2052181 ttgaacaaga tccccgatgc gatcaatact gttccagctt aaatgatgtt cgattccttc 2052241 gacatcgtta tatattttct cttcatcaac accaatgatt cttaaaaact gctcaagcaa 2052301 ttcatgtctg tataccagcc gtttgcctat ttttttccct ttagacgtta acacgagacc 2052361 gcgatatttt tcataaatta aatattcgtc tttatctagt ttttgaacca tttttgttac 2052421 agaggaggga tggactgcca atgcttccgc gatatcggaa actcgtgcat atcctttttc 2052481 ttcaatcagc atataaatct gttcaatata atcttccata cttggtgttg tcatcgaaac 2052541 cctcccaaaa agcaccttaa ctttataaac cattacaagt ttacactaat gaacttgaaa 2052601 aaacaaggat gctccgcggg tcaaaagccc tgtttaccgc ttataattcc attcatctga 2052661 agcgtacttt gtttcagcca agtgatgaac aaaatcaagc tcttcctgag aaagttcata 2052721 tggctccaaa tgaatgttaa gacctgtttc aaatccttct ttaaaggctt tacgagcctc 2052781 atccatcgtc acccgctttt cgatgagttc attaatggca accgctttat ttttgaaatt 2052841 gcgctgcatc cgctctctta ctctttcact tggatataag aacagatcga acagcttgtc 2052901 ctcatctaaa tcaagaagaa tggagccatg ctgaagaatc acaccttttt gtctcgtttg 2052961 cgcgcttccc gccaccttgc gcccctcaac cactagttca taccacgaag gcgcgtcaaa 2053021 acaaacagat gaccgcggat tttttaagct ttctttttct ttttcagttc tcgggatggc 2053081 aaagtaagcg tccagaccga gatttctaaa gccttgaagt atgccttctg aaataacccg 2053141 gtaagcctca gtaacagtcg ccggcatctc ggggtgctct tccgaaacaa ttacgctgta 2053201 tgtcagttcc tgatcgtgca gcacacctct cccgccggtc gggcgtctga cgaatccgag 2053261 attatattta tgtactgctt caaaattgat ttccttttta atattttgaa aataccctac 2053321 agaaagtgtc gccggattcc agccgtaaaa acggataacc ggggggattt tcttttcgct 2053381 gtgccaatat aaaagcgctt catcaagcgc catattgaat gcaggacttg cattgcctga 2053441 gtctataaac cgccaagttt ctttttgcat tttaagacct tccttaccgt tttaatagaa 2053501 tcagtttatc aaactgtcgg gaaaatgaaa aatattttag ttccattata gatgacaatc 2053561 acgctgtgct ttactataat agtatttgtc gaaaacggct ctatgacctt gttttatgaa 2053621 gcagggtttt gattttatat gctaaaggag tagaatcaca ttgtctaata tgatcgtttt 2053681 gattattttt gctgcattta tcatctatat gattgcttca tatgtctatc agcagcgaat 2053741 tatgaaaaca cttaccgaag aagaattccg cgcgggttac cgcaaagcgc agcttattga 2053801 tgttcgtgag ccaaatgagt ttgagggcgg acatatttta ggcgcccgca acatcccgct 2053861 ttcccagctg aaacagagaa aaaatgagat ccgtacggac aagcctgttt acctgtactg 2053921 ccaaaacagt gtccgcagcg gacgcgcggc acaaaccctg cgcaaaaacg gctgcactga 2053981 gatttacaac ctaaaaggcg gctttaaaaa atggggcgga aagattaaag cgaagaaata 2054041 aagcaaacag ctgtctggta gacagctgtt tttatttatc tttcttccgc ctcgtatctg 2054101 agcactgggt gtctcgccgc ttttgtttca tccattcttt ttacaatcgt tgtatgcggg 2054161 gcctcctgaa caagctccgg attctcctcc gcttcttttg cgatttgaat catagcatca 2054221 ataaacgcgt ccagtgtttc ctttgattcg gtctctgtcg gctcgatcat gatgcattct 2054281 tcaacattaa gcgggaaata aatcgtcggc ggatgatagc cgaaatcaag gagccgtttt 2054341 gcaatatcaa gcgtacgcac tcccagcttt ttctgccgct tccctgataa tacaaattca 2054401 tgcttgcaat ggcggtcaaa cggaagatcg taataaggcg cgagttttct catcatataa 2054461 ttggcgttta acactgcgtt ctcagtaaca gcctttaatc cgtcaggccc catggagcga 2054521 atatacgtat acgctctcac attaatgcca aagttgccgt aatacggctt cacacggccg 2054581 atcgcatgag ggcggtcata atcaaacgta aagcgccctt cttttttgac taaaactggc 2054641 tttggcaaat aaggaatcag atcttgtttt acgccgacag ggcctgagcc ggggcctccg 2054701 ccgccatgag ggcctgtgaa tgttttatgc aggttgaggt gcaccacgtc aaatcccata 2054761 tcaccaggtc tcgccttgct taaaacggca tttaaattag cgccgtcata atacagtttc 2054821 ccccccgctt ggtgtacaat ttccgccatc tctgtaatct gctcctcaaa caagccgagc 2054881 gtgttcggat tcgtcagcat aagagctgca gtttcttcat tcactgctct ttttaaatcc 2054941 tctaaatcaa caagcccttt ttcattcgat ttcaccgtaa cggtttcaaa gcctgctact 2055001 gttgctgatg caggattcgt cccatgcgcg gaatcaggga caatgacctt cgtccgcttg 2055061 aaatccccgc gagcttcatg ataggcacgg atcatcatca gccccgtcca ttcgccgtgc 2055121 gctccggcag caggctgaag cgtaacctca tccattcccg ttatttcttc aaggtgtttg 2055181 cttaaatcat ataaaagctc taatgcgcct tgcaccgtgt cttcatcctg aagaggatga 2055241 atcgcagcaa aaccaggaat acgtgcgatt ttttcattga ttttcggatt atatttcatc 2055301 gtgcaagaac cgagaggata aaaaccggaa tccaccccgt gattgcgttt ggacagcgct 2055361 gtataatggc gcatgatgtc cagctctgaa acctccggca gcgctgcgtc ttcgtcacga 2055421 atataggtgt ctgacaagag gtcccccaat tcgatttccg gtacatcgag ctccggcaga 2055481 ctatagccga ttcggccttc tcttgaaagt tcaaaaataa gtgcctggtc ctgattactc 2055541 atggcgatcc cccaattcct gaatgagtgc gtcaatttct tcttttgttc tcagctctgt 2055601 tacagcaatc agcatatggc agtccagctc tggatacgtc aacccaagat catatccgcc 2055661 aatcatgcct tttgccagca aacgcttgtt cacagctctc accggctcat ccagtttgat 2055721 gacaaattca ttaaacatcg gcccgtcaaa cataacagta aggcctgctt tttttgcttc 2055781 ttgctttgca tagttggctt ttaagagatt ttggcgggct atatctttta cgccgttttt 2055841 tccgagagca gtcatggcca ctgatgctgc cagcgcattt aaagcttggt tcgagcatat 2055901 atttgatgtt gctttatccc ggcggatatg ctgctccctg gcttgcaggg taagcacaaa 2055961 gcctcttttt ccgttttcgt cttccgtttg tccgacgaga cggcccggca cctttctcat 2056021 taatttttta gtaacggcaa aaaagccgca atgcgggccg ccgtatgctg aaggaatgcc 2056081 gaaaggctgc gcatcaccga cgacgatatc agactgaaac ttgcccggcg gagtgagaag 2056141 acctagcgcc agcgggttgg ctgaaacaat aaacatggat ttcccttgat gagcgatagg 2056201 ctcaatatcc tttagcggct cgatcctgcc gaaaaaattc gggtactgaa cgatcactgc 2056261 ggctgtgttc tcgcaaacgg tttggcgcaa tgcatcaaga tccgtaacgc catccgcagc 2056321 gggtacttca acaacatcaa tatactgacc ttttgcgtaa gttttcagca cctctcgcga 2056381 ttcaggatgc acggtttttg acacaacaat ttttttcttt ttcgtgtggc ctgaagcaag 2056441 cattgctgct tctgccaagg ctgttccgcc gtcatacatc gaggagttgg cgatatccat 2056501 gcctgtcagt tcacagatca tcgtttggaa ttcaaaaata gcctggagct ctccttgtga 2056561 aatctctggc tgataaggcg tatatgcggt ataaaactca gagcgcgaaa tgacatgatc 2056621 cacaatgaca ggctgatagt ggtcatatac acccgctcct aagaaagaag cgtattgtac 2056681 ggtatcacga tttttagagg ccagctttgt cagttctctt gttaattctg tctctgattt 2056741 cgcttttttg atttgatgct cttttttata tttgacgttt tccggtatat cagcaaataa 2056801 atcatcgatg ctgcttacgc cgatagtagc aagcatctcc tgtttatcct tttctgttgc 2056861 gggcaaataa cggtgcttca tgtgttgtct cctctctcca agaaaaaata ttagcgttta 2056921 taaaatggtg ttttgacaac ctttgctttc actaattttt tgcgtatctc tacatctaca 2056981 acagtcccga tctcactcgt ttccgaatca attaaggcaa ggccgacgtt ttttcctaat 2057041 gtcggtgact gcgtgccggt tgtcaccttt ccgacagact tgccattttg gaaaacctca 2057101 tatccgtgcc gcggtatccc tttttcaatc atttcgagac cgacaagttt gcgcttcgct 2057161 ccgttttctt tttgttcact caatactgac ttaccgaaaa agtcagactc ctttttgtgc 2057221 tttacagcaa agcctatacc tgcttcaatc ggtgtaatat cccgggtcag ctcctgaccg 2057281 tagagcggga gcttcgcttc aaaccggagt gtatcacgtg caccgagacc gcatggaatc 2057341 aatccgtatg catcccctgc atcgatgatt tttttccaaa tatgcatagc atcatcactg 2057401 cggcagtaaa tttcataccc gtcttctccc gtatagccag tgcgtgaaat aagtgctttg 2057461 cggccgctga tatcggcttc atcaataaac gcaaacggct ttaatgcaga cacatccgca 2057521 tctgtcagat tttttaagat cgcttctgct ttcggtccct gtacagccaa gagcgcgatt 2057581 tgatctgact gattgtcaat ctgcacatca cctgctgcat gttctttcat ccaagccaag 2057641 tctttatcta tattagaagc attaatgaca agcagatagc ggttctctcc tttttgatag 2057701 ataagcaaat catcgacggt tccgccatcc gggtaacaca tcgctgtata ttgagcacgg 2057761 cctggcgtta acgcggaaac atcatttgtc atcaatcttt gcaaaaaaga cagactgtcg 2057821 ttccctgaca cttcgacttc tcccatatga gatacatcaa acaaaccggc tgcagttcgg 2057881 acagcctcgt gttctttttt tatagaagaa aattgaacag gaagctccca gcctccgaaa 2057941 tcaatcgttt ttcctccata ttccttatac aggtcaaata acggcgttct tttcagcatc 2058001 taattcctcc cctttatcaa cggcgcagct aaaaaacata caaaaaagga cagagaaaca 2058061 cctcatgtaa aatgaaggtt ctctgtcctg gcacctgaaa gtttactttg catacgcaaa 2058121 gacgtcccct ttggtggttt gcgcatccgc acaaacactc tccagagttg cgtcgagcaa 2058181 gagttctttt gcctgagaga ttcactccgc agtttgctcc ttcggcgcct gtatcccgag 2058241 gttttcggtc aggtctctcc ccttgctgtc attcgctcat attttcatgc tgttatggac 2058301 atactatagc aatatcttac atcaaataca tactcatatc ctaccatcat cactatatgc 2058361 tgggcaacag caatttgggc agatttttct tatattattc atcttaagaa tcgaagaata 2058421 agaaaggcgg tttcaaagca atgaatacag aaatgatcta cgatgcaaaa tggcctgaag 2058481 aatttgctga aagactgaaa aacgatggcc cttgggcaaa ctgggaactg tacaagctct 2058541 ctgcagaaat ccagaaaaca ttagcaattc cagagtttga aggcttacgg gctcctttat 2058601 atctgccttc ctttacgccg ctcccccacc agcttgaagt ggcgcaaaaa gtggttgaaa 2058661 aaatgaacgg gaaagcgatt ttagcagatg aggttggtct cggaaaaacg gttgaagctg 2058721 gactgattct aaaagaatat atgattcgcg ggttagcaaa aaaaattttg atccttgtgc 2058781 ccgcttccct tgtgtcacag tgggtcaaag agcttcagga aaaatttttg attccggctg 2058841 ttgaacaaaa gaaaagctat gtgtgggagc aatgcgatat tgtcgtctca tcaatagaca 2058901 ccgcgaagcg ctcgccccat cgagaaatcg ttctgtctat cccatatgat cttgtcatta 2058961 ttgatgaggc acacaaactg aaaaatagca aaacgaagaa ctatgaattt gtccggaatc 2059021 tcgtaaaaaa atattgcctg cttcttaccg cgacgccaat ccagaaccgt atcgaagaga 2059081 ttttcaattt ggtgtcctta ttaaaacccg gccatttagg cagtcagaat cactttcagg 2059141 aggagttcgc caagaagaaa tccagtttag aagcgcatga acatttaaaa gatcttgtga 2059201 ataaagtcat gatccgtaac aggcggcatg atacagggct gaattggaaa cagcgccatg 2059261 ttgaaacagt gccgattcaa ttttctccat cagagcaggc gctttatgat gaaatttctc 2059321 gtttgaagga cagtatcaat aaaccagcca gcatgttctc gattatgacc ttgcaaagag 2059381 aatgctgttc gagcagagaa gcggtatata tgacgctgaa aaagatgctt gatcaaaaag 2059441 agaaacaagc acctgccatt gatgaggata cgatttcagt tttgatagat cgcatcaatc 2059501 aagtgacaca aaactctaaa gcgcttcaag ttgttgactt gatcaaaaag atcgacgata 2059561 aggtcatcat ttttacagaa taccgcgcaa cccagattta tctgcagtgg tttcttcagc 2059621 aaaacggcat cagttctgtg ccgtttagag gcggatttaa acgtggaaaa aaagactgga 2059681 tgaaggatct tttccgcgga aaaatccaag tccttattgc aactgaagca ggcggtgagg 2059741 gaattaacct gcaattttgc aatcacatga tcaactatga cctgccatgg aacccgatgc 2059801 ggcttgagca aagaatcgga agaattcaca gactcgggca ggagcgtgac gtgcatattt 2059861 ataacatggc gacaaaacat acggtggaag agcatattct aaagctttta tatgaaaaaa 2059921 ttcatttgtt tgaaaaagtg gtcggtgaac ttgatgatat tttaacgaaa attcaagtga 2059981 acaattttga agagcacctt catgacattt tgtatcactc agcaacagaa gaagaaatga 2060041 aaataaaaat ggataactta acctcatttt tgtcttataa aaaacagctg cctgctgaaa 2060101 aaagaggatc ttagcctgta aggaggtttt attagtgaga cagcaagagg ttcacgattt 2060161 tctgctgcgt ttttttcaag caaacagctg ccaaatcgtc gatcaaggct taggctatat 2060221 gacagtgcag cttacagttg aaatggacaa acaaatcatg aaccgccctt tctactggca 2060281 ttggcgcgag aagacaggcg gtgatccgaa tccaatgaaa atcactttta ttacagataa 2060341 agaaaatgcg ccaaaagacc tagatggtga atttatatat tttggggccc cgcgtctttt 2060401 tcaaatattc aaagctgtta aacaaaatgg gagatttacc agaatgtatg agaaaattga 2060461 atcagccgga gctaaagtcc cacttcagcc ttggcttggt ataaatgtca cgatttcata 2060521 ccagtccgac atgaaaaagg ataagttatt gtcactaggt cttcacctag tctctggaac 2060581 gataattgaa gattttcaaa gcaagctgac ccagttttca ctgacgtctc aaatatgtga 2060641 ctattgcttc accatttcac ctatgatcaa accagaaagc ggacttaagc gtatggaaaa 2060701 ctatatttcc aaatccgcta tgcaggagcc gtccgactgg gcggaacagg cggttaacag 2060761 gtggaagaat gatatgacat tgcttgataa gttttacgag catatagaag aaaaaccaga 2060821 agaataccat ctagaaaaac aggcgctgaa aaccttgtat caaccaaaga tatcagttga 2060881 aattgaaaat ggcggattgt tttatctgca aaataatatt tcaagctaac ttttttacca 2060941 ttcgacatca ttctcgtttt ttttgagaaa atacgattat aataaaggta tattggaaaa 2061001 aaattctggt gatttaatgg caaatgactt ccagagacta atgaagcata caataagtca 2061061 tggccggact ggctgaaata cataaacaag tattttagga ggagaaactg catgaagaat 2061121 gcaaaacaag agcactttga attggatcaa gaatgggttg aattaatggt ggaagccaaa 2061181 gaggcaaata tcagcccgga agaaatacga aaatatttac ttttaaacaa aaagtctgct 2061241 catcctggtc cggcagccag aagtcatacc gtaaatcctt tctgaatgtg ctataatatc 2061301 acaaggaagg tgatgacatt gattggccag cgtattaaac aataccgtaa agaaaaaggc 2061361 tactcactat cagaactagc tgaaaaagct ggggtagcga agtcttattt aagctcaata 2061421 gaacgaaatc tacaaacgaa cccctccatt caatttctcg aaaaagtctc cgctgttctg 2061481 gacgtctcgg ttcatacttt gctcgatgag aaacatgaaa ccgaatacga tggtcaatta 2061541 gatagtgaat gggagaaatt ggttcgcgat gcgatgacat ccggggtatc gaaaaaacaa 2061601 tttcgtgaat ttttagatta tcaaaaatgg agaaaatccc aaaaagagga gtagtgcctg 2061661 agcagaggca ctaactcctc ttttgtcaat aaccatcgag acggcccagt atatgaatac 2061721 tgggccgtct cttttttttg ctgttattaa tttttatcct cgctatgcgc gagctcgtct 2061781 tgctcagtat tgctcatttt ttcaattttt tagaaatttt tgggattgtt atgtgagaat 2061841 ttaaatgcat atcccattat tatttggtaa taataaacaa agaaagggtg acagcatgat 2061901 gatcaaacaa tgtgtgattt gtctatctct tctcgtcttt ggcaccacag ccgctcacgc 2061961 agaagaaaca ccgcttgtaa ccgcccgcca catgtccaaa tgggaagaga ttgctgtaaa 2062021 agaagcaaaa aaaaggtacc cgctcgcaca ggtactgttc aaacaaaaag tatgggaccg 2062081 taaaagaaaa gatgaagcag tgaagcaata ccatttaact ctgagggaag ggtcaaaaga 2062141 attcggcgtt tttgtgacga tttcatttga tccttatagc caaaaggtca ataaaattgc 2062201 catattagaa gaatatcaat aaggtcctcc attttttgaa ggaccttatt cgtttatttg 2062261 cggttatttt ttccgtttca gccaaagtcg gaagccatag ggtaaaatac cgaaccactg 2062321 ctgggaaaca ggcgtttttg tttctttccg cacctctttt cgttcttttc gctcatctct 2062381 cggagtatct atatatttga caaattgctg cgtcatatat ttaacataat cattcgtttt 2062441 cacgtgatca cctcatcatt caattattat gagtgttgtc tcacatgact ttttttatac 2062501 cctttacact gttttattct gtccatctca gcagtttttt ctgtttttgg tcaaacacga 2062561 tctgtgcagt tctttctgtt cccgaatccg ttgacactct taagttgatt tctttttgtt 2062621 cttttatcga tgtatcatga atgtaataag aaacccgtcc atatagaaat tgctgcgtac 2062681 cctcctggcc tttccgttcc tctagaacat gccgaatcga aagaagcacc ccattttgaa 2062741 gcaaattctc tcctatgtat aactcttttg tttccttctc aaacatgcag cgtgaaatat 2062801 attgagcagc aacaaagttc acgattaaca gcacaagcgc tgacacaaaa agaacagctg 2062861 gataaataaa ccctcttgta cgatacattc acccccctcc taaatacgaa tagactggaa 2062921 aagcagtttg atacactttt tggtcttcac tctcaatttt cagcaaaaca acaccatttt 2062981 caatatcagc tttcatggca gtaatatgat ctaaaatcgg aacatgccct ttgccatcca 2063041 ctctttttct tatcattgaa tgataaatgt caaaacggat gtcttgtccg gaaagattgg 2063101 tgcagattaa cacgctccca tgctcggctg tcttaactgc ctgtgattcc ttgcattcat 2063161 tcatcatctg ttctatcgaa atcatccatt cctgctgtgt gaaaccgtca tgttcctgct 2063221 gtcgagacaa aaacagatgg ataatcgcag ctaacgatcc tgatatgagc aaaaagactg 2063281 agagcgaaaa taatacgtta agaagcgtgt agccattctg tctgcaaaat gctgaggcaa 2063341 aatgattttt ctttataagc tgcggctttg atacatacgt tttgatattc gccctcctcc 2063401 tcccacttca ttgcatagat atgattgttc tttgtaatcg tttttgacgc ggctccttca 2063461 ccactcatga catatttgct aatgctctca ttcatcatct gatagccaat ttctcgtgat 2063521 tccgccattt tttcatcagc catcagcttg tcccacaagg ggacgactgt cagcagcaca 2063581 aacagccaca ggcttagcgc agacattgtt tctattgtag aaaaaccttt attttctctc 2063641 cacattgact ctcccgctcc ctagataaac tgttatgtca taaacggcat ggccttttac 2063701 tcgtattttt ccgcctgcat tcgggtgccc tttctcatta aattccaaac ggtcttttaa 2063761 tgtcagcagt tctatagaaa gtcccgttgc atacggacgt tcaataaccg tatcaccaat 2063821 gactaattga tattcttttt tatgaaagag aatttttgtt ctttgttgac gggaaatagc 2063881 agtctgctgt gtgagcataa tatcattttt cagctgactt gctgcctgtc ggacagctgt 2063941 attgtcataa gcaggaggaa gtgtagtgaa gacggccacc aggaggatag aggcaaggct 2064001 taacacaagc aaactttcta aaagggtaaa ccccttctcc tcgtttaatt taatgttcaa 2064061 ccttaacttc tccgccggtg atgataatgc gcttaccatt tggacagaca gcatcctttt 2064121 tcacatagcc ctctgactgt aaatcggcaa ggctcggagt ttgtccttca tgatcaagct 2064181 caaatgcagt catttgtgcc ttaaccatgt tttgtaagcc ttcacagccc tttttttgaa 2064241 tggtttgatt atgtttcgtg acgttcggta tcgtaattaa aagcaaaatc gaaataataa 2064301 agagcacgat taacatttca acaagtgtaa atcctttctc attcatcagc ctcttccttt 2064361 cacatttgat tcatcatctg atacataggc acaagcatag ataaatacac aagtaagatc 2064421 atcgctgcaa caaatccata aatcattggc tgaaggatgc ctgtccattt ttgcgctttg 2064481 tgttccagcc gctgtaatat gaattggctg tatgtgaaaa gctcccgatc caatcggccg 2064541 ctcagctggc cgtgagatat gacttttgat aaatcagttt cataaaaaag gcttccacaa 2064601 atagcggatt caattgactc accggctttt agccgttcaa tcaattgttc agcctcgcag 2064661 cggtagaaag ggagaaacgt ttgatgttta aatgcattaa ggctgtcata aattgagagg 2064721 cctgatttta aaaggctgct tagctgcaaa gaaaaaaagt agctgttaaa cagctttaca 2064781 agctttccaa ccaaaggaat cctgatacaa atcagcattt gccgggcagg tgattttttc 2064841 ttaaacacaa gccaataata aatcccgata cctgctgtaa aaagaacaag caaaatgatc 2064901 acaagatcaa tatgctgaaa aaaagcaaaa agcatatcgg ttgaacgtga ggtttccata 2064961 ttcatcgatt gatagatacc ggaaaactga ggaatgatga tggactgtaa catataaaac 2065021 atgacagcga ccgtaaagat gaggaaaagc ggatagcgca gcactctttt cagctggtct 2065081 gcctgtgcaa tttttcgttc cagcagctct ccgctctgga tcattgaagc aggcagttca 2065141 ccatgtgttt cagcaaaata acaaatacct acggcttcct tatgaaatga caaactcttt 2065201 agtacttgat aaaacggagc cccttccctc aaacaagtga ccgaatcagt caagtcagcc 2065261 gcctgcctct tattcatctg aagttccatc aggcgtaatc catccagaag tgtatatccg 2065321 cccgcagtca tttcaccgag cctctttaat aacctggctt gatcctttaa caaccagact 2065381 tttctaatct ttttcatgat aaacccaccg gtcatagttg tttgtcgtta aatagccgag 2065441 cgcaattcct tttctgataa tttgacgaag cgtttgatat tggtaatttg catgatttcc 2065501 ttttgcctcc tggatacatt gctgaagatt tttcccgtat agaagctcat aaacgctagc 2065561 tctcctagta tttcgtgact gtcggcaata cactgatgaa catccgtttt cacaaaacgg 2065621 gcaagccaaa tcaaccaagc gctgagccgc tattgcaatg acagtctgtt cgatttcatt 2065681 catattgata ccgaattcaa gcagtctgta aattgcgccc tttgcgtctc tcgtatgaag 2065741 gctcgttagt accagatgtc ccgtcatcgc tgcccgcacc gcaatttcag ctgtttccgc 2065801 gtctctgatc tcacctaaaa taatcatatc ggggtcatgg cgcaaaattg ctttcagacc 2065861 tgcggaataa gttacaccgg ctttttcatt cacctgaacc tgaagaacat cttcgtccct 2065921 tgtttcaaca gggtcctcta atgtgacaat atttcgatta aagtgttttt ttgcatattg 2065981 aacgagagag tataatgtgg tagtcttccc tgaaccagtc ggcccggtaa aaatgagcat 2066041 gccatgggaa tgttttaaaa acgagagtaa tgtggctcct gtcttcggaa atagcgacaa 2066101 tttatcaatc gaagggatat tgtattgggg catcactctg atcacgaggc tttcttcatt 2066161 aattgtgggc agcgttgaca ttcttaaatg aacatttccc tctttcaact ttaacgtaag 2066221 cgaaccgttt tgcggctttc gcctttcacc tatatccatt gctgaaagaa atttaaaatg 2066281 tgaaatcagt cttacgcact cttctttttt catgtccctt tttttcagca aggcatgatc 2066341 gacccgaaaa tgaatgatag cgtcccgctc cctcggcaca atgtgaatat cagaagcctt 2066401 tgttagatat gcctcttcaa tcaagttttt gcttaccttt tctattgaat ccaatttgat 2066461 tccctctcct ttcaacgcat attgtagaaa aagaagaaaa ggtaatcaaa cagggaaaac 2066521 gtgattttgt gagatgttat atgctgaaaa accaattctt tctggcaaga aaaaagactt 2066581 tcaactgaat gtacccctgt cattataatt ttccctataa ataaaaaagc agacatggtc 2066641 accatgcctg ctagattcca ttttcattat gctgttttcg cttattgacc agtatctttc 2066701 tcaacggaaa gatcgcctaa tgcaacaata ccggtcattt ggtcattttc aagaatcgat 2066761 aaactgcgga tttaatgctc tgtcataagc cccttgacat cgtatccggt caccctgata 2066821 tgtctggtga aaaagcgggg cacgctgcac aaaatatgaa acatcctata gagtccgcct 2066881 ttttcgaggt ttctttttct tcttccgctc ctgcagcata tctcccgtcc agcctttttt 2066941 tctcaaatag agatagatca gaactgtaga tgtgacaatc aataagaggg aaaagagata 2067001 tccgtatttc caattcagtt ccggcatcac tgaaaagttc atcccccata aggcacccag 2067061 agctgtaatc ggagtaaaaa gcgtcgtgaa aatggtcagc gcttttacaa tttcattccc 2067121 cctatgtgag gtaatgactt cctctgaatg cagcagattg ttaagctccc cttcaaattc 2067181 gctgatgtat gtaaatcccc tgtcaatctt cagttgtgtc cgctgataat cctttttccc 2067241 ttcattttga ggtaaaaagg tttctttcaa cgccatttca atttttttag cgcttaatat 2067301 caaatttttc caaatcatca gttcatggcg caggagatgg acgcggttta aaatgctttt 2067361 gctattgtcg tctttaattt gccatctgag ctttctcagc ttgacttcaa attcatcaac 2067421 accgattaaa tacgcattca ttagttcgcc gagaagaatt aaaaacccct ctatcgcatt 2067481 gtccgctctt tccatttgcc gaacaacttc tttgccttta atctctctca aaattgaaaa 2067541 gtcaaagttg attgtaaaaa aatattgtct ggtgatataa aagtgaaaaa cagtatggtc 2067601 tttttcttca ccaagcccct gatcataaac aatcgaccca aatactgctt cattttccgt 2067661 ttcagttgta tctactcgca aaaaattaac gtgatggtta ttttcaaacc acttttcaca 2067721 ctgaggccag tgagaaaaat ggattagatc tcttgcctta cttctttctt gaggccccat 2067781 ttggtaccaa aaccaatcct ttcccgtatg tgccttcatg tcaagctcct ccaaactttt 2067841 gttctttatt ctttaattgc ccaataaccg cgtcactaaa ccagtctgcc gcttcaacac 2067901 atgttttatg agcattttca ggtggtatgg aatgtagaaa gacatcggaa aagggaggtg 2067961 catgccttcc ttggagaagg cagttgtttt ggaatttatc aatttactag cagtcgctat 2068021 tctcattttg ttaacaggat ttttcgttgc cgtagaattt tcaatcgtaa aagtgcggcg 2068081 atccaaaatt gatcagcttg tcgcaaaagg aaagaaaggt gctaaagcgg caaagcatgt 2068141 catcactcac cttgatgaat atttatcagc ctgtcagctg ggcatcacag tcgcagcttt 2068201 aggactggga tggcttgggg aaccgactgt gcaaactctg cttcgaccgc tttttcataa 2068261 agcaggctta aatgaatcgc ttacccacct gctttcactc gtcatcgcat ttttagtggt 2068321 tacgtattta aatgtcgtta ttggggagct ggcgccaaag agtttcgcca ttcaaaaagc 2068381 agaaagcatt accttgttgt tcgctaaacc gcttatttgg ttttataaga tcatgtttcc 2068441 attcatttgg ctgttgaacc actctgcccg attgattaca ggagtgtttg ggctgaagcc 2068501 ggcatcagag catgagctgg cttatacaga ggaagaactt cgggtcctat tggctgaaag 2068561 ctataaaagc ggcgagatca gaaaaagtga attaaagtac atgaataata tcttcacctt 2068621 tgataaacga atggcaaagg aaattatggt gccgcgaaat gaaatggtta gtttgtcact 2068681 agatgaagac tccatttcaa atcttcagga aacagtcaag caaacaaaat atacacggta 2068741 cccggttgta agagaggata aagataacgt cattggcgtg attaatatga aagaagtgct 2068801 gttttccatg ctgacgaaag atttttcaat caagaagcat caaattgaac ctttcgtaca 2068861 gcccgttatc catgtaattg agacgattcc tatttataaa ctattgctga aaatgcaaaa 2068921 ggaacgcact catatggcga tcctcataga tgaatatggc gggacgtccg gtttggtcac 2068981 tgtcgaggat attatcgaag aaattgtagg agaaatccgt gatgaatttg atgcggatga 2069041 agtgcctcat atccgcgaac ttggaaagga tcattacttg ttaaatgcaa aattattaat 2069101 cagcgatgtt aacagcctgc ttggaaccga tttatcagag gctgaagtag acaccttggg 2069161 cggctggttt ttgacacaaa acatagacgc tgagcctgaa agtgccatag aatatgatgg 2069221 ctactctttt aaggtaaaag acatcaacag ccatcacatt ttatttatag aagttaaaaa 2069281 agctgaatag cccgtgaaag gctgttcagc tgctatcttt caagataaac atggcaaagg 2069341 catcaacact cttttatttt aaacccttta ttggccaggg ctttagcaag actttgctct 2069401 gttttcacat tcgaaaaatc cagacccagc ttcacgacag tttgggcaat ttccggcctg 2069461 attcctgaaa taatagtctc aatgccgagc aatttggtgc tgtcaatcac tttaaaaatt 2069521 tgataggcta ccatggtatc aacgatagga acgcccgaaa tatctaaaaa taaatacgag 2069581 agctttaacg ctgagcactg ctccagcaca gactccaaaa tcgtcctcgc tctgtgcgta 2069641 tcaatttcac cgacaagcgg aagaatccca attccatcag taatcggcat aatcggcgca 2069701 ctcaattcat taatcatttc tttttgcgcg tttaattgta tcatggtcac ctggtgatat 2069761 tcttccgtaa acacttcgat gatctcatca atgttttgat tcaagatccg gctccactca 2069821 taaaattcct gaatgctgat gtcttgagaa gaagcttcgc tgaatttatg aatccattca 2069881 aacatgatgt gcctgaaagt gttaaactgg ccgacacttt gtgtaaccgt cacttcatga 2069941 acggcacggt ctctggcgca ttgaagagac caccggttga gctcatcctc tacgtcttct 2070001 tttctaaggg attttgctac gatggtcacc aataattcat gctggtcttt taacttttgt 2070061 tctagttttt gctgatcttt cgctgaatac agccagctgc cgtttgacgt acaaacttcc 2070121 agccattgtt gcgtaatatc ttttttgtgc tctgttaagt gctgatcaag agctatcatc 2070181 ttaatgagtt acctcctgtt tttgaaaaat gtacgctata tatgtataac gcgtctgcct 2070241 ttacacatac tatgtttaga ttcaatgggc tatagccaag cggtaaggca atggactttg 2070301 actccgtgat cgttggttcg aatccagcta gcccagtttc tgaacaggtg aaaaaccgaa 2070361 gataagctga ttcgtataaa tcagcggatc ttcggttttt catcatgcag attgatgaac 2070421 cgttttcttc ttcgataact tcaacagttc tcccgggtta taaccaatca ccagcttttt 2070481 gttgtctact agaatcgggc gtcgcaaaag cttcggcttc tcgattaaaa gttccagcac 2070541 ctcatttacc gtcatttctt caatgtttaa atttaaattt ttgaaagtct ggcttcttgt 2070601 cgccaaaatt tcatcaattc cttctgtcgt taacgataaa atgtacttta attcttctct 2070661 tgtcggggtt tctctgaata agtgccgttc gttaaattca atttgatgtg ctttaagcca 2070721 atgttttgtt tttcggcatg acgtgcagct tggatatgag taaaaagtta attgttgttc 2070781 cattcgtttt ttcctcctca gttaaccatc tctttgtaga ataactaccc ggatcatttt 2070841 tcatttaaac catttacaga acttttttcg gattattttt taaaaaacat tcatacaata 2070901 gaaaacacaa tcaaagggac aaattccatt tgtatattaa taatgaaaat gtttacattt 2070961 ctaggtgtga tctattataa taacagtcag agggactctc gggaggggat aaaaatgaat 2071021 cgcatgttcc gggtgttagg attttggacg ggaatttttg cagtcatgtt ttatttaggt 2071081 gatatgaaag atgcttccct tttatttttt ggacagacga tcttatttgt gtttctatcg 2071141 tatttgaact taaccgaacg catgtatatt tatatttttg gcgcttattt aacaattttc 2071201 ttcgccggct ttacatatta ctcaattttt attatggtgc ccggcggcgg aggccattaa 2071261 atgcagaaag agacaaacct tatcggtttg tctctttttt tacaatgaaa acccatttaa 2071321 aaacggattt tgatcctgct cagtcagtac gtctgtttca ggtccatggc cgcttaacac 2071381 cagcgtgtgt tccggaagcg taagcagttt ttcatgaatg gacgtcagca gcgtctcttg 2071441 attgccgcct attaaatccg tacgtcctat accgccttgg aacaagacat ctccggaaat 2071501 gaccaagtct gcatctttca cgtagtaaga cacactgcct ggtgaatgtc ccggcgtaaa 2071561 taatgtttcc aaatgaaacg gcccgatatt caactcaccg tcgccttcaa ttagatgatc 2071621 tgcaggctta gctgtgactt ctatccctcg cagcatgccg gagccgttta aagaagcgtc 2071681 cgcaagccaa tttttttcat tttgatgcag gtaaacaggg atatcccatt tttctctcac 2071741 ttcatcaagc gccccaatat ggtcaaaatg ggcatgtgta agcaaaatgg ctaaaggcgt 2071801 cagccctttt tcttttatgt attgattgat tttatgtccc tcgccgcccg gatcaaaaat 2071861 cagacattga tcatcactga tgagaaaata tgcgttcgct tgaatcggcc ctactggcat 2071921 tcgtctccat ttcactatta tcacctcttt cttttttatg ctcttattat gagggttttt 2071981 gaaaaaagat tcaaacaatc gcaatgaaaa cgctatcgac aaacctataa aaaacaggta 2072041 gaataaaact ggaaagaatt gcaggttttt caatgtaaag ggggctgtgt tatgttactt 2072101 gtcgtgattt tcggccttgt cgctcttttc gctttatggg gagtcttgcg ttctgttaga 2072161 aataaaaata tactcgggtt tttattagcc ggtgccacct tatttgtctt tggatggttt 2072221 accgtgatga ccgtaataaa cagcgggtat ccaaccgcac attaaaacct gtatccgatc 2072281 ggatacaggt ttatttttat ggctgtaaat gtttattgac actttctatt ttgctctcaa 2072341 gcgtcgtttt tttgtcacgc ctgtcatcga tacggatatt cgttgccact ctgtgcaatc 2072401 ctttttgaaa tggcgcttcg tgaattgcct gaataactgc aaaaaggtca ctgagttctc 2072461 cctcgatcag cgtattcatc ggtgtcagct gatatttgat tttcccttct gcttgatatc 2072521 cttctaatat cttttgcaca tcggctacgt aagcactgac actgggtgtt tccgtaccga 2072581 ttgggataat ggttacatct gcgatagcca tcgttattcc atctcctttt gatcaatgat 2072641 gagttgcttc gtttcatgtg atttcaataa aataatttgc tcaaaatgaa agccgtataa 2072701 cgcatatttc ccgttcggag atatttgaat cggctccatt tcccgcagag acacaagatc 2072761 ttttgtctct cccgatgcta cattgattgc tgcgagctta tatgcatcgc cgctttgttt 2072821 gaatgtataa aacaggcctc ctgcttcatc atagtcatac tccattggag ccaaacttgt 2072881 atatttcgct tggagcggcc atttcgctgt aacaggtgat gttgattgcg gcgttttaaa 2072941 ctgatacgtc ccttttcctc cggaagctga tttgacagta aaactcattt gatggaaaga 2073001 atcgaagaat agaacgttat cctcaagctt ctgttccgtc ttagaagctg tatcgaacgt 2073061 atataaaggc cctgttttat cgtctctacc ctcttttaca taatcaaatg tatttttgga 2073121 tgtccaatga atgaacggaa cctgtactgg gcttaagaaa gattcgtctt ttttagcatt 2073181 cacctgatat gtatggaaat cccagttttc attgaattcc gtcaccatca tttgataagg 2073241 atcatactga ttccaagcag cttcaagctc atacgtttcg taatcttttt cgtaaagcgt 2073301 ctctccttct gcattaagca aaaccactgc cgtcttttgg ctatgtgtga tttgcagcag 2073361 aatcatctgc tccctcgcat tgatttgaac atcaacgatt tgaccatccg tttgatagag 2073421 ctttttcgct ttgcctgtaa agatgcggta cgcaaaaagc tctgttttcg tcggattaga 2073481 cgcagtatat aatattgtgc tgttattcag ccagccttcc gccccatccg ctttttccgc 2073541 ggaaagcggt atgatgtctt ttttctcatc ttttgccgcc gatgcctgtt tttgctgctg 2073601 atgagatggt tcgcatgccg ataaactaaa cagcaatacc gccagcagaa taaaacaaac 2073661 tgatctcatc agcattcccc tccgatcatc tttattctct catatttgct tcggcagaaa 2073721 aaagaaaaag tttcagttac tcatgaaaaa ataacgccct ccacaagata ccgcttgtgg 2073781 cgttatatat gtgtgaaaac tgctgaaacg gcaaaggatt ttggcctttt ccaagttcca 2073841 ccgtataccc ttccttaaaa taatggtgaa taaaccaatc acgaaatcca gcatagctgt 2073901 ctatatccct tactccctta taaatgttcc cgcttaactc ctcaaactcc tttatgacgg 2073961 cagcagattc ctcaggctca aggcctttat agccccaata aatttcttct ccttgagtat 2074021 gaagagccag cagtctgtca ggcggattct ccgtgatcag ccggtacatc gcaatagatt 2074081 ccggctccgt aagcggagag attcccggaa aatcgcggta gctgggtgct gtcggttttc 2074141 ggtatttttc aatttcccat aatgatggaa attgtttatt taaatcaacc ccgtttatat 2074201 tcgccttcca ttcattaaaa tttggacgat gttcatttag cctttcgagt tcatctcttc 2074261 tggctcccat gacttctgat ccgtttaaaa caagatcaac gccatccgga ttgacaagag 2074321 gaacgaggga taaggatgtg ctgttaaaca gctttatggg agaaaagcca aagaaaggcg 2074381 aattgcagca taatgacata cagtattcct taaaccattt tagcaggaca gacgttgtaa 2074441 tccactcatt cgcatgaaat gacgcgttca tatggacctt ttttacggca tgctccccac 2074501 cagccttcag ctcccagata ggcctgccga gtacagaacg gccaatttcc cggcatgaga 2074561 caaacggaaa aacatcaata atcttcttta tttccttttc aacagctgaa tcatcataga 2074621 ttttctcttg ctcaatccag ctatctgaaa gtttcagctg ccgaggctgt aaaaagcgct 2074681 ttatgtcctg aatggtttga agctctttgc cgctatgctc ctctatcaca taaccagggc 2074741 aatacaattg atgtttttgt gcggagcgat ttgcactttt aagcaattcc tcgtctatct 2074801 tcagttcttt cgccacattg gccaaattgt tcttgatctc aggtttcacc gtaataaacg 2074861 ccatcatcat cccccttttt tgttactata tgacagcgta tttaaaaaaa gaaagcctcc 2074921 cgctcacttc gatgcgggag acattgtgat tatgatgcct gatcaagcat ttgtttttct 2074981 ttccgctttg acgaattgtc cagccttttc tggtcataaa atcgcaacaa atccccataa 2075041 atgatttcat cagaaagtga tagctcctgt tttgctttat cagcaaatgc ttcacattgt 2075101 tttgtctctt ctaacggttt tcccgtctct ttgtcataac acgcaccgtc tgtataaaca 2075161 acctgatctg tgataaagct cccgtcccgg agcaccgtga agtccagttt ttcgtctgaa 2075221 agcagatcgt tgccgaattg aatttgatct ttcgtatcaa tccctaaaag attcatcagc 2075281 gtcggcctga tatcaatctg cccgcctact gtttcaatgg tttgcggctt tttatcagta 2075341 atacccggaa tatgaatgac cagcggcact ttttggagct gtacctcttc aaatggggtt 2075401 atttcttttc ctaaaaactg ccccatcgct tcattatggt tttctgatat accataatgg 2075461 tcaccatata atacaataac agagttgtcg tataacccgt cttccttcag cttttcgata 2075521 aaccgtttca gcgcctcatc ctgataacgc actgtcggaa aatatttatt tagcgtctgg 2075581 ctgtttgaat catattcatc aatcaattga tcctcttcat caagatcaaa cgggaagtgg 2075641 ttcgtcagtg taatcagcct cgagtaaaac ggctgaggca gatttttcat cagctctgag 2075701 gactgctcaa aaaattcttt atccttaagt ccccagccga ctgaattttc gtcagttaca 2075761 tcatacgagt taatatcaaa aaacgaatca tatccaaatg agtcgtacat taaatcacga 2075821 ttccaaaagc tcttattatt agcgtggagc accgctgaat agtatccgct gtttttcaaa 2075881 atttcaggag cggccatata ttgattgccc gcattcgtaa aaaatacggc acctcgtcca 2075941 agcggataca gtgaattgtc cacgataaat tcagaatccg aggttttccc ctggcctgtt 2076001 tggtggtaaa cattattaaa gttgtagctc tgttttataa agtcattcag aaaaggcgtg 2076061 atttcttctc cattcaattt ttcattaatc acgaagcttt gcgtcgactc taaggatacg 2076121 agaatgacgt tccttccttt tgcagcgccg aataagcgtt tgttggcatc cttcgcatta 2076181 gcggttacgt agttttcaat ctccgtcagg ctgttgctgt ctgccaacgc tctctgtgcg 2076241 gattgctttg actgaagaac gccatcgtaa atatgaaaat taaacaggct aatgttttta 2076301 acaagcattt ctctgtcaaa tgagcgtgtc aatagctgag gtctttccgc ctcagacaag 2076361 cccaggttga agaaataaac agaagcaacg aacaaaaaat aagccgcccg ttcatttttc 2076421 gttgagggaa tgtccgattg aaaagctttt tgccggatgt gaagccatat taaaaccgca 2076481 atatctacag ctaataggag gtctgtcggc tcaagaagtg ttccgatgct gcttccgaga 2076541 tcacccatat tgctcgtttg aaaaagaaca gggattgtta agaaatcatt gtaaaaacgg 2076601 taaaaaacca tatttgccag caatacaaac gtgacaagac agctcatcgc gataatgtag 2076661 cgatttctgt ttttgccttt taaaaacagg ctgaggccaa aaataagcaa caaaaaactc 2076721 aatgggttga taaacagaat aaattcctgt gttagattgt cgattttaat atgaaaactg 2076781 gttttgtaaa cagcatacgt tttcagccac atcaataaaa tggcaatcag cataaatgaa 2076841 atcttcgaaa aaaacgtttt tcgcatttca acctcctatg cagcacgctc aaaaaaatca 2076901 gtctattccc aacattctca ttaacacatc aaattaaatc ttaacctgag cacaacaaaa 2076961 aatcaatttc atttacacaa ttttaacaat tttgatgttt cagccattca tttttagcga 2077021 tccaagcgcc tccgataacg ccggcatcat ttccaagtgc tgcgattgaa atatcagcag 2077081 cttgggctgc ccgcggaaac gcgcatttgc ggaatgtttt ctcgactttt gatctcagca 2077141 gttctccggc tctcgatacg ccgccgccaa gaacgatttt ggatggatta agcgagcttg 2077201 ccaaatttcc gagcaccaaa ccaagatgct tggctacata atcaaccacc tcaagggcaa 2077261 tttcatcatt ttcacccgcc gcttcaaaca catctcgcgc tgacaattgt tcggttgctt 2077321 ttaaacgtgt cgtcttttta gcatttgcta ttttttcttt tgcaattctt acaattccgg 2077381 ttgctgacgc aattgtttcg atacagcccg ttttgccgca gttgcagggc gctccgcctt 2077441 cagggatgct gcaaatatgg ccgatttctc cgccggcgcc atttatacca tgtacaattt 2077501 caccatttgc aatgatgccg ccgccaactc ctgtgccaag cgtcacgaga atgacgtctt 2077561 ttgcgccatc acccgctccc ttccacattt ccccgagcgc agcaatattc gcgtcatttt 2077621 ctataacagc tgggatgccg gtttctgtct ccagatggtt tttcaaagca taatttttcc 2077681 accctagatt tactgtttca taaaccactc ctgccgccat atctacaggg cctggtgcac 2077741 ccattccgat gtatttgatg atgtgcttcg gtttttgcag ctcatccagc ttgctgtcga 2077801 ttgtttttgc aattgtgaca gtaatcgtgt cgccggtttt atctgtcgga acttcccact 2077861 tatgctgaat ttcgccatat tgattaataa aagcgagttt aatcgtcgtt cctcccaggt 2077921 caatgcccgc aaaccatatc tcgtccattt ttatcacctt agcctttata aaaatctctt 2077981 ccgttttttg tttgttccaa ttcttttcga aggacagctg ccgctctggc ccactgctcc 2078041 ttttcaatca tgtggttcat gtataattcc tttaattcat ccagcataaa ctcaatttca 2078101 agctctctgt ctccaaaata aacaatgtgg ccaaacgttt ttaacagctg ctgcacatca 2078161 taaaatgtat tcattttcct caccatttct tgaacttaac tatcataagc gtattcataa 2078221 ggaagcggtc agtcaagaag aaaacgctga caaaaaagcc agcttccttt ccatattcca 2078281 cctctatgat tctttattgt tttcaatttg ccgctgcagc tccttgtagc gctgctcctt 2078341 cggcttcagt ttcacagccg tctggatggc cttttctgct tgtgcaagct catttttttc 2078401 cgcatacaat aacgctaaat tgtaatagga agcatggtct ttaggttctt ttttcactgc 2078461 tcgttccaaa agggaaaccg cctgatcata ttcgccgatt tgaatatcag aaacagcaag 2078521 aattttcaaa agatcggcag aggcatcttt ttgcgctgct tctccgttca gcaattctgt 2078581 tacttcttca tactttcctt cctgatacag ctcgcttgcc tgctgaatca gcgctgactc 2078641 ctggtgtgaa ggcgaatgca atccgtaata taaaaatcca acagccaaag caatcagcaa 2078701 aaccgctgac aacaatcttt ttccaaaggc tccggcttta ggcaacccca gtgctgctgc 2078761 agcgaaaaag ccgccaatca agccgccgat atgtcctgaa ttatcaatat tcgaaaccgc 2078821 aaaaccaaag cccagattga tgataataat gacaataata ttggttccta tagttcttaa 2078881 aaacattttt cgattagaca aagcaacata cagtaatgca cctaagcatc cgaatatggc 2078941 tcctgatgcc cctgccgaag gatacgggct gaacacaaaa ctcgcaatcg aacccgtaat 2079001 gccagcagcc agataaatca gcaaaaatct ccccgatcca tacatccgct caaccgctgt 2079061 accaaccgac cataaagcca gcgtattaaa agctaaatgc gctatgccga tgtgaagcac 2079121 gatcggtgtc agaagccgcc accattctcc ttgtgcaatc aggctgtttt cttttgctcc 2079181 aaaagccacc agtgtctccg tattagtgct gcctccgttt atttcgagca agaaaaacat 2079241 caggatctga agcgcaataa ataaatatgt aaaagtcggt tttccgtttt gaaaaaccgc 2079301 cgcttcagtt tttctctgtt cttcttgttt cagcactagc gaaaggaagc gttctcgcgc 2079361 catttgcgcg ttttcaaacg aagcgtgttc ctctgaacaa tcttctgtac gaaatgatgg 2079421 aaaaaccgct tgaagatcat ctcgaagcat cgttcctcta acgatcgccg gctcaactga 2079481 cacagttccc ttctcaaaag ttttttttgc aatctcttcc cagtcatcaa ctggggcttc 2079541 cgttgaaaaa aacacgttca gcagcttcat ccttcgtctg cccaattgat gtctgactcg 2079601 ttctactcgt tcggcctgct cttcgatgtc tctaaccatt tcttgacgga aatcaagatc 2079661 gtgcttataa agacgaacta gatcatgaga ggacttgtcc ggcgcttcca gccatatttc 2079721 atctgactca ccggcttgta tgacgccata cccgctattc accaggtgcg ccgcaatttt 2079781 ccaatatgta tactccagca aaaacatgtt taccgctcca atagtttttt ttcattataa 2079841 cagctggcgc tccgaaacgc ctactgaaag caaaaaatcc cgtttttcac gggattttag 2079901 aaagcttgct gtataaactt attgcggata aatggaattc ttaaaaacaa atggataaaa 2079961 gaccgcctga ttcctggctg gctgagtaca gtattcataa gacggtagcg attttgataa 2080021 aacatgacgg cagaaaccgc gaaaatggca tatatcaaaa gttttttcat gatatccctc 2080081 ctgccaatag ggtttgttat tctaccttat ttattctcga ataagggaca ggaaagttat 2080141 gaaaaacaag aaataatccg atcctctgtt atcagcttat gtaccgggat gtcatgcggc 2080201 agacggggta cgtgcgcaaa caactggcac tccaaaagca aagagactgt cttcccttca 2080261 tattcactta aatagcgatc ataatagccg cctccaaagc cgaccctaaa cccgttaaca 2080321 tcaaaacaaa cacccggaac gatcatcaag tcaatttgtg atgggtttac ttcttttgtt 2080381 ttttcaatta ccggctcgag cagtccggcg tacacggttt cgagctgatc atcagtctga 2080441 tatgtgcgaa attgcatttt cttcgtgtcc ggatggcatt ttgggatgca aacttgtttc 2080501 ccttcttccc aagcctgctc aatgacagga cgcgtcggta tctctaatcc tctggaaata 2080561 gtgacggcaa tggtgccggc attttgccac tccggcagag aaaacaagta cttatacata 2080621 cgttccgttt tttgaagaat atcttcattt gataaagcag acagtgcctc cagcgtcttt 2080681 tttcttaatt gtgatttcat ctctcatccc cctcggaata gaaaaaaagc cagaaccttt 2080741 ttcaaagctc tggctttttt cttacacctc aaacagcaaa gctgttattt tgtttcacgg 2080801 tgtaacgtag attttttatc acgtgggcaa tattttttaa attcaacgcg gtctggattg 2080861 ttgcgtttgt tctttttaga aatatagtta cgctcaccac attcagtgca agccaaagta 2080921 atattaacgc gcattatttt ccctccaaac taaaatcatt tacttattca gacttatata 2080981 taataccact ataatggacg gaatgctagg ctgtttttca atgaattgct gaattattga 2081041 agatacgctc ataaagctgc aaatatgatg acataatgag tcgggggtgg tggagcttga 2081101 acacttgttg tctgccagct tcttttatcc ggcgggcttt ttcccggtct tttaaaaaac 2081161 tgtccagcag atcagcagct tcctgtacga gcgtaaaatc agcgatgatt gccgttttgt 2081221 catgaaccgc ataatcacaa aaaccacctg actgagaaac gacagtcagc acaccttgtt 2081281 ccatgctttc ttgcgcggca agcccaaacg gttcataaga actagggaaa acagccattt 2081341 cacagtgaga cagtaacgtt ctgatatctt tcctatttag aaacggcaga aacatgacgc 2081401 gatccttcag gttatatgcc gcagccaatt tctcatagca ggacagagac ggcccctccc 2081461 cagccagcac tagatagagg tcaggctgac gctgcttcaa gatggcaaac acctttaaca 2081521 gctgcgataa tcctttttcc ggaacaaacc ttccatatga aaagaggaat cttctattca 2081581 tgcttctcgg gattttcccc ttctcttcct ccatagatgc agggcttggg ataacggtta 2081641 ttttcttatg tgccgcctta tcaagagacc gcttcataaa tgtgcttaat acgatcaatg 2081701 catcagcgga ttctataagg agccgttcgg tcatgagcct gtatgggtgt ggggcttctc 2081761 ggcacacctt cttcctttcg ctttcaagac cgtggattgt cgcagcaagc ggaaggccaa 2081821 gccgttgttt caaatactgg gcggcagggg cagttgtgtc atcatgggca tgaatcagat 2081881 caaagcgttt attgtgtgat aacacatggc gaaccattgt aaagttagca tcagctatgt 2081941 aatcttcaaa cttcgcatac gaaaacagct gcccgctcgg agtaaaaacc gtaatgttga 2082001 tatgagggtt taaataggaa atgaggcggt ttaaatggac accgagcccg cttttcggct 2082061 catcgggatg ttcgggtgaa agcatgagaa tgttcaccgt tctttttccc ctctcccata 2082121 acaggtgtat gcagaaaatt gcgcctccca cctggtgtgc gcttcttcaa tctgaaaact 2082181 gtttatatga cgaatcccat tttcatcaag atagatgtcg tctgtaccgg caagcttgag 2082241 agagacattc attgaattca caattctgta ttcagcccga tatacagcat caccagccgc 2082301 ctgtctaatc gtccattctc ctttatcata cgttgtgcgt tttgtcctga cagcttcaat 2082361 gtcttttctt ttgatgacaa tgcgcaattc ttttatcata tcctgcgttt tttcgaaaag 2082421 gaccgcttca gccagccgca ttgtttcttc tgagatttcc cagcttacgg tcaaggtgtg 2082481 agcgttttga atgattatgt cgaatgtgtc cctaaaaaag gaaagcttat gtcgtatatt 2082541 atagggaaat gggtgtttat ccatggactc ctaacattct cctttccaat cgttcacttc 2082601 gtgttcctat taaaccatta catgaagaag aagcgaagaa agatttctcg acaaaatctc 2082661 gtttttttcg cgaattcctt tagaaactat tggttttatg gtataaaaaa gaaggataaa 2082721 aaaagaatag aaggtgatga aacgtggaaa ttgctattat tgcgttgttt atcgtcagta 2082781 tagcgctaat tgcattctca tattctcaaa gagacccgat gaaagatgta gaacaggagc 2082841 tcgaaacact gcagctttct gcgatgcagg aaatttacaa gctcaaaaag aaaatgacag 2082901 tgcttgagga agaattactg gaaacaaacc ttgtcattcg caaatcaaag cagaacgaca 2082961 tcaatcaaaa aatcgctaaa caaatacttt ctaaatataa taacggtatg tcagctgaag 2083021 cgattgctaa agctgaacat gtatcagtgg aagacgtgaa tacgattatc aaagataatg 2083081 agaaggtgct cgtatgacaa aacggggcat tcaggcattt gctggcggca tcattttagc 2083141 gacagccgtt cttgcagctg ttttttatct gactgacgaa gaccaggccg ctgctgtaaa 2083201 agataataaa acagtaaccg aacaagacgt gaacaattat cttgattcta aaaaattggt 2083261 ttctgtcaac cgtgatgaat atcaaaaact tctcgattca aaagagaaat ccttaaacaa 2083321 tgacagcggc tcagacacga aatcagacaa agtcaaaacc tacaagctca ccattaaaga 2083381 cggcatgagc acggcggatg tatctgctat tcttgaaaaa gagggcatta tctcttcggc 2083441 tcaagacttt aatgactatg tcattgatgc cggctatcac aaagaaattc gtgccggcga 2083501 gtttaaagta aaatcagaca tgagtttcaa aaagatcgta aaaacgttaa cacgataaaa 2083561 aaacaggctg actcagcctg tttttttcat ccaaactttc ctgaaatgta atcgagcgtt 2083621 ctttggtcct tcgggttaga gaacatttta ttcgtattgt cgcattcaac aagctcgccc 2083681 atgtagaaaa aggcggtttg atcagaaacc cttgctgcct gctgcatgtt atgcgtgaca 2083741 atgacaattg tatatttatc tttcagctct agaatgagtt cttcaatttt tctcgttgag 2083801 attggatcta gtgcagatgt cggttcatcc atcagcaaaa tatcaggatt ggtcgcaagt 2083861 gctctggcga tgcaaagacg ctgctgctgg ccccctgaca gcgaaagagc ggacgtatgc 2083921 aatcgatcct tcacctcatc ccataacgcc acgtctttta atgacttttc cacaatttcc 2083981 tgaagcttct tcttattttt ggtgccgtgg actctcggtc cgtaagccac attatcaaaa 2084041 atagattgcg gaaacggatt ccctttttgg aataccatgc cgatattttt tcgcaaatcc 2084101 acgatgtcca ctttatcctt taaaatgttg ctgccattat agttcagctc acctgcaagc 2084161 tttacattcg gcgtcatttg aatcattaaa ttcaatgtct tgataaaggt cgatttcccg 2084221 catccggatg gtccgataat cgccgtaacc tcattttcat aaatgctcaa attgatattt 2084281 tttaaagcat gatgctgccc ataccataag ttcattccat tgacttgata tacttcctgt 2084341 ttcattacag cttcggtagc aatactcatt gccgccctcc tatccgaatt tcccgttaat 2084401 ataatcctct gtcttttgct ttttcggact cgtgaaaatc tgttcggtct gtccgtattc 2084461 tacaagctcg ccgtttaaaa agaatgccgt ccggtcagaa acccgcagag cctgctgcat 2084521 attgtgcgtg acaataataa ttgagtattc tcttttcaat cctgtaatta attcctctat 2084581 ttttgcattt gaaatcggat caagcgctga agctggttca tcaagcagaa gaacagccgg 2084641 cttcatcgca agcgttctcg cgatgcataa acgctgctgc tggccgccgg ataacgagag 2084701 tgcggatgaa tgtaaacgat ccttcacctc atcccagagc gctgcttttg ttaaactttc 2084761 ttccacaatt tcatctaaaa cagctttatt ccgctctccg gcatatttca atgcatgtgt 2084821 gatattcgca tagatcgatt tcggaaatgg atttggtttt tggaaaacca ttccgatttc 2084881 tcttctcaag ctgacaacgt taatattgcc gcccaatata tttaatccct cataaaggat 2084941 ttcaccttcc gctcttgcag atggaattaa atcgttcatt cggttaatat ttctcaaaaa 2085001 agtagatttt ccgcatcccg acggcccaat taaagcagtc accgcatttt tttcaatatc 2085061 catgtttaca tgatgaacgg cttgtttatt tccgtaataa atggacagat ctttgacctc 2085121 aagcacgtgg ttctgcttcg gaacaataac agctcgctca ggtttttctt ttaccatttg 2085181 ttcagacatg tttttcgcct ctttccgttc taatttgccg taagcttttt gtagatcatc 2085241 gtgccaagcc atctcgccgc gagattaaac acaagaacag aaatcaccag cacggcagaa 2085301 ccaccgttgg caatcgcttc agcatccgga atcattcctt gtgtattgac gttccaaatg 2085361 tggaccgcaa gtgtttcagc gggcctgaaa atattaagcg gtgatgtttc cgaaaacggg 2085421 ttccactccg taaaattaag acgcggtgtt gtcaggcctg ccgtaaataa taatgcggcc 2085481 gcttccccga acacccttcc tgacgctaaa attgctcctg tgatgataga aggaatcgca 2085541 cttggaatta aaactgtttt tacggtatgc cagcgtgata cacctaaagc gagagaggct 2085601 tccttcagat ctttagggac tgaacggatc gcgtcttctg tcacacgcac catgacagga 2085661 aggttaaaaa cagttaacgc aagcgctccg cctatgatcg tataacccca gcctgttaag 2085721 ttgacaaaca tcaataatcc aaacatccca atgacaatag acggaagaga tgaaagcacc 2085781 tctatacatg ttctaatgaa gtcagttact ttgttattag gcgcgtattc agccatgaag 2085841 actccgccgc ccacaccgag cgggattgta atcagcattg taataaacaa aatataaaag 2085901 gagttaaaca gctgatctcg tatgcctcct ccagctgcaa tggcgctcga ctttgttgta 2085961 ataaattgaa aactgagctg agaaacaccg tttataataa tataggaaaa caaacctact 2086021 aaaatggcag cgataatggc tgcacacaaa ccaaacattc cggtcgccag tttatctgtt 2086081 attttgcggt tcattacact ttcctcctag atgacaagta gcgaataagc aggatgaaca 2086141 agaatgacat caccagaagc acaagcccca ttgaccacag cgtattgttt tcaacacttc 2086201 cgtatgtggt gtggcccata ttcagcgtga tgatcgttgt cagcgttccc gcagtgtcaa 2086261 acgggctttc cggcaatact cttgtatttc caatgaccat ctgaacagcc aaagcttcac 2086321 cgaacgcccg agccatgcct aacacaacag ctgtcatcaa tgttggaaaa gctgcaggca 2086381 caagtacttt tctgatcgtc tgccatcttg tggcaccaag cgcgtaagaa ccctctcgta 2086441 aactcttcgg aagagaagcc attgcatcag cagaaatcga tgtgatcgtc ggcagaatca 2086501 tgacggaaag gacaatcgtt cccgccaata aactgtgccc tgttccgctc gatttgaact 2086561 gggcgataaa cggcaccaat actgtaagac ctatgaatcc ataaacaaca gatggaatac 2086621 cgactaaaag ctcaatcacc ggctgcagca ctttctttcc ccaattcggg gcaatctctg 2086681 tcataaaaat cgcacctgca atgccaagcg gcgcagcgat tagagcagaa agaatcgtta 2086741 ctgcaaatga gccaaaaata aatggcagca ctccgtattt cggatcacta tctgtaggat 2086801 tccaatttaa gctcgttaag aattcaattg ggcttacacc atttacaaga aaagattgca 2086861 gccccttaac gccgaggaaa atggtaatcg caacagatgc cgcaatcata atcagtgcac 2086921 aagctgtgac tatcattctt ccccgaactt catccaattg ccgattttgc ctagagctga 2086981 ttaagcgctc gctcacagac atattttctc tattgtttat cattgtttta cactcctatg 2087041 aatgtgttaa gaggagaaac ggttgtcccc gcactcctct ttttattaag atcagctttg 2087101 cttcccgttg gcatcacgtg tcactttcat atcagtaacc ggaatgtagc cttggtcagt 2087161 aacaatgctt ttttgaatgt cttcactctt tagataatca agaaattctt tagctaaacc 2087221 tgtcgcttca ccttttgtat aagaatgttg ataagcccag atcggatact cgccagttgc 2087281 tacatttttc gcttcaggtt taacaccgtc aatagataga gcagttactt tgtcatctgt 2087341 taaatatgag aatgcaagat atccaatcgc tcccggagta tcagcaatga tctttttcac 2087401 cgtgttggag gaatcttcag taatgccttc tgcaggctcc gctccgtcaa gcgcatattt 2087461 cacaaatgta gcacgtgtgc cggaagaatc agggcggttt acaagtgtaa tcttttggtc 2087521 tttgccgccg agctctttcc agtttttgat tttgccagtg aagatttttt tcaattcatc 2087581 ttttgaaata tcctttacac cagcatcagg gtttacagct gctgccatac caactacagc 2087641 gacttgatga tcgacaagcg cttttgcatc gatgccttct ttttcttcag caaaaacgtc 2087701 tgaattcccg atctgaacag ctccttcaga gacttgagaa agccctgttc cagaaccgcc 2087761 agcttgtacc tgtatatcag catcagggtt ttcttccata aatttttccg cggctgcaag 2087821 tactagtggc tgcattgccg atgaaccaga aatggttaaa gaacctgatg ccttttcttc 2087881 tccttttgca gaatcgctat tcgatttttt actttctcct gcatttccgc atgcagctgc 2087941 aatcatcata aaagcagcca tcagaagcat aagcaccaat ttgttttttt tcatttcctg 2088001 aattccccct gcgtataatg tgtaatttgt cctacacgta tagagtaaag gttctatgta 2088061 aaaagggttt gaaccgaatg ttaaggtttt gtaaatcagt gcgttttttt gtataaaaaa 2088121 aacgcccaca tcatgtgagc gttttttttt agttatcaga agacgttgtg ttttctgcat 2088181 tttcttcaat tttgtcttta ttcttttgct gagtaccttc tttgtcctgc ttcgatttca 2088241 gctcaaaata tttatccatt acttccctgc cgatttcgtt tgtaattgag tatctttgat 2088301 tgtaatcaat gtaagtccaa ggaactacga cagaaatagc aatctcagga ttgtcagctg 2088361 gtgcataagc cacaagcgtc gtattataag tgtctgttcc tgtttttgat ttatccggtc 2088421 cgtcgtaaaa tgattgggct gttcctgttt ttgcagctgg tttatacgat gctgaagcca 2088481 gttgacctgc agctgtccct ttagtggcaa cccgtctaaa accggcttgg acctcttcaa 2088541 tatagctact cttcatatcg actttattca atacttcagg ctgaacagaa tcaacgactg 2088601 cgccgatccc ttttttcgca tttgaatctc tgacttcctt tacaagctga ggcttcatgc 2088661 ggtagccacc atttgctatg gtggagacat attgagccaa ttccagcggt gtataagtat 2088721 catactgtcc aatggcgaaa tcaagcaaga aaccagataa tctgcttgta cctttatatc 2088781 ccgtcatttc atttggtaga tcaattcctg tttttactcc taatccaaat tgactgaaat 2088841 aatttctgaa ggtatcaaat gcagaagtat ccaaaggcaa tgcttggtga ggtttatatt 2088901 cacctttacc aactgcaatt gctgttttaa acataaaaac gtttgatgac ttctctaatg 2088961 cagtttgaat accaaccggc cctaagtttt gccaagattt tttccctctt ttatcctggc 2089021 cgatatacaa tggttcatcc ttaaatacag tattcaaatt aatcgctcca gtttgaagac 2089081 cggtcaaaac ggttgcacct tttacagctg atcccatagc gtaggatgaa gtcatggctc 2089141 ctaatgcata atcatcaaac ttataggctc cattttctcg tttaatctgc ttccctgcca 2089201 ttgtcagcac ttcgccgttt ctagggtcca tcatgacaac gaatgcacga tccaacaatt 2089261 cggtactagg tcttgcttta gcagctttaa gttttttctc aataattttt tccactgatt 2089321 tttgcaaatc aatatcaatt gttagtacaa gatctttccc ggctttgcct tcagataccg 2089381 tttttgttcc cgtgacattg ccttttgaat ctgtgatatt ttcgactttt gctttttggc 2089441 cctgcagaag gctttcatat tggtattcca gatagctttt tccgaccctg tcatttcggc 2089501 tgtagccaag cgacagataa tggtcgagca agttggacgg caatccttca ttagagctgg 2089561 aaacacttcc gagcactgag cgaagaaggt ttttataagg atattcacgt tcccaatcgg 2089621 acgtgacatc aacacctggc agttcgtcta aatgttcact taccactgcc atttccttcg 2089681 ctgatacatc ttcgtttttg atatattgag gggtcaatgc atagcccgaa tccatctgtc 2089741 ttttgatagc aaggatctgc atatctttat ccgtcaattc attcagctgc ttatcagtaa 2089801 tccgttttag ctgaagctgg tataaatcgt catcggatat ttttttgtct tcaacctgct 2089861 gtctttcttt agagctaatg agctttttcg cttctttcgg tctagtcaaa atccaataat 2089921 cttttttatc ccgttctgtt actttttttg tatcgacttt gatcatgtca gacagctttt 2089981 ttgcgatctt taagcgctgt tcttgcgtgg tcgatttaga tctcgtgtat gtgattgcat 2090041 ttaaagcctt atttgtcaca atggcattaa agtttcgatc ataaattttc ccgcgtggta 2090101 ccgctgagct gacttcactt tgttcctgct tattcgcttg gtttttgtaa tcatcacctt 2090161 gcacgatctg cttgatgccc agttccacaa taatccaggt aaatataaca aaggcagcta 2090221 aaaataaaat attcagccgg atcggaagcg acttcttttt ctctttatga ttttgctttt 2090281 ttggtttatt tctcctcata acatcacctt ttctatttac agaaagaaaa gacactcaag 2090341 taagagtgcc agttttcatt ttaaaggttt tttcgacttt tttctacaga taaccccttt 2090401 ttggcaaaaa aattatctct cgccttttaa aagggtcggt tctgttaccc gtttttggcc 2090461 gtcttcttcc atggtttcat tttccccttc tttctcctta aaacgaatat ccttgacaaa 2090521 gtaataaatc aaaggatgtc ctatacccaa tatcgcaagt gacaaaggaa ttcccacatc 2090581 ctctttcaga agggccacaa tcaggagaaa gcacaaaatg gaaacaattc tgccggcgtt 2090641 caagaacatt tctctaagca cgatatattc aattcttgct tttctggcat gcctcgcgcg 2090701 ccctatcaca tcatatgtaa gtgatacata tggcacaagc aacagaggat agccgatggc 2090761 aataaaaacg ccgtacgtta ataatgtcga aaagctcata tggaacagaa tcaaaaacag 2090821 cgcgccatac aaaataagtc cgcccagcaa aatcgatttt tttctcgcct ttttcttaat 2090881 cagcctggat gcaaagtagt aggcaaagaa ggaaacagct gaattgacaa gaccgaatgt 2090941 accgagagca agctcgctgt ttgtctcaat aaatacaaac acactgatta aaaagacaaa 2091001 aatcccttct ctcaaaccct gaaaaaaatg cgcattcgtg attctccgcc aattcatatt 2091061 gctatggcgc tctccaaata ctttgctcag cataaaacgg ccctttgatt ctctccgttt 2091121 taagaaaaag ctcatcacga cagccagggc aaataaactg agggagagac tgaaaatcac 2091181 tgtataaccc gtattatttt caagccttga gatcacgaat ccggctacaa tcgggccgat 2091241 cattcctgca gaggaagaca gaatgcccat aaacccgttg aaaaagtctc gtgtatccgg 2091301 ctctgttatt tcaaaggtca gcacgttaaa cgctagccaa taaaagccat agccaactcc 2091361 gagcaccgcg ccgattagca cgaggcggct ggccgccgtt tctccggcta aaagcacact 2091421 taaataaaag gcagctaaaa aaatgacgcc gaaccttaaa atgaataccc tgtctatttt 2091481 tttggctaac cgtccagcca aataaaaggt tatcggctgc attgtcacaa tggataaatt 2091541 atatatcgcc aaatcaataa atttccctga ctgcttccaa agatacacat taacaaatgt 2091601 attggacagt gcaattccca gcgagtaaag cccgccaatg gtcagcagaa agagtaagcc 2091661 tttgtttacg tctacatcgc ctatcacttt ttttagtttg ctcattactg actccccttt 2091721 actatccctt agtctgtctc actcaaaccg agatatgtaa aaagaagaca taaaaaaaca 2091781 aggtcccata atgaggacct tgtttgtgcc attattttgc ttcgctgtat agacgagcca 2091841 cttcgtccca gtttacaaca ttccagaaag ctgaaatgta atcaggacgg cggttttgat 2091901 agttaaggta gtaagcatgc tcccaaacgt caagacctaa gataggcgtt ttgccttctg 2091961 aaagcggaga atcttggttt ggcgtgcttg tgatttcaag tttaccgttg ttcacaacaa 2092021 gccatgccca gccagaaccg aagcgtccag ctgctgctgc tgcgaattgc tctttgaatt 2092081 tgtcaaagct tccaaataca ctgttaatct cttcagcaag cgcgccagtc ggttcgcctc 2092141 cgccgtttgg agataaaagt gtccagaata atttgtggtt cgcgtgtccg ccgccgttgt 2092201 tgcggactgc agtgcggatg ttttcaggaa cagaatcaag atctgcaaca agctcttcaa 2092261 ctgatttgtt ggcaagagca gtgtttcctt caaccgcttt gtttaaattt gtcacgtatg 2092321 tgttgtggtg tttcgtatgg tgaatagtca tagtttcctt gtcgatatgc ggttctaaag 2092381 catcgtacgc ataaggtaat tctggaagtt cgtaagccat gataattcct ccttagtata 2092441 tatgtactga aatgccgctt cacagcgagc ctttcttcat tcaatgtaac aaaagaatgc 2092501 tttgtaatca atgaaaaagc tcacgatttg gctcatttca gcggacatat ttcactttaa 2092561 ccgataatct gccccattaa acctgccgcc agcatttctt ataggaccgt ccataaaaag 2092621 taaccgatca tcaaaagctg tatgatgccc tttgcaataa cccctgttaa aaaaccaatg 2092681 agtgagccga ggccaatttt aaacgctgac tttaagtcct tctgatggac gataagttct 2092741 gcgcaaacag ccccgataaa cggccccaat atgatccctg caaccggaat gacaaaaggc 2092801 ccgattaata aaccgatcgt gcttccccat atggcagctt tgcttcctcc gaaccttttt 2092861 actccaagca gattcgacac gtaatctgct gcgaataata ctgcggcaaa aactgcctca 2092921 acaagccaga acatataaga atacggactg aatgaaaata aaaatccgta caatacaaat 2092981 ccggcaacaa taaatactac gctaggaata acaggataca ccagcccgat aaaggcaatg 2093041 ataaaaaccg ctgcaatcaa cagccaatac aacatatcca tagcttccat cctcccattt 2093101 tactctgtct tcttcatgtc ttccttgtat tcacacgcat gcaacgatac aataagcaac 2093161 atatattagt ttagctagga agtgaagata gtgaatgtgt ttcagctttt cattaaaagt 2093221 acatactctc cccgtgatat tgcaaaaaca agatttcaag gaatcggaaa agcgattctt 2093281 tatgtatttt tgctctctgt cctgtttgca atccctaccg cttattatgt aagtacaggg 2093341 accgtaaaat caatgaacgg ctttaaaact gttttaaaca aagatttccc tgatttcaca 2093401 atttcaaacg gcaaacttca aacggatgag aaaaaagcca cggaatctca ggcaaatggt 2093461 ttcgttatcg tgttcgatcc gacagactcc tatggcactg aacaaattga agcaaagcaa 2093521 aacgcaatcg gcatccttca gaacaaattt gttttggcca ttgacggaca agcccaagaa 2093581 atgtcttact caatgatgcc gtcagagtta cagaaaaaag atgtcattgc aggtttaaac 2093641 caaaataaag cgatgattgt aactgttctc tcagctctta tttttctcgt aacagcagcg 2093701 ggaaaattta ttgaagtatc gtttttagcg cttatcgggt taatcattaa gaattcgcag 2093761 aaaaaacatt tatcctatca tcagctctgg aagctttctg cttattccat cacactttca 2093821 actgtattct ttacaatcat gcgggcacta gaagcaaccg taccaagtga atttttgctg 2093881 aactggtttg tcaattttgt catcctgttt ctcgttttaa aagagattcc gtccaaaaaa 2093941 gtaattaata aaagttaaat tatatttatt tttatccttt aagtagagag tgtgaaagca 2094001 tttgcattaa ctttttactt aagggatatt taataaaatg tatagagctt aaacagatac 2094061 atttataaaa aaagctctac aattactcaa gaacaagctc tggacaataa tatcagaagt 2094121 agtaagatgt aacatgaaag aagttcttaa cagcatttga catatgtttt taacaaaata 2094181 agaataatgt taaattttaa ctaatagact agttaaaatc atatggcaaa atattttgca 2094241 tcctttcaca acatatttac ataagatagt tgctatttaa aaagccaggt accaataggg 2094301 cacctagctt tcagaattaa atcatcaaca agttagaatt atcttctttc cttctattct 2094361 cattattgaa ctgttatctt ttttgtgggt ttatgtatac aaatgcagct cccttagctt 2094421 tccccttata tactgataaa cctactgccc aaggtgttcc tgtcggtttt ggtaatttac 2094481 tgaagtaaaa ctttttggtt ggagttctac ttgaaaagta ccctgaatat tgcgggccaa 2094541 tgtccccacc ctcaactata gatacaccaa agctcttata atttagttta ccgcattttc 2094601 catttgtttc ggcgtaagca tcaatagatg ttgcactctt agtatatgta taagcatctg 2094661 taataactct tattttacaa ccagaaatac cacttaccgg ttgccaacca ctgcttgcag 2094721 cctctgcttt ttctttaggt gcaactacca aagttaacat tagtagcaaa attaaaaaca 2094781 cagaaaattt tccttgcttc attttgtaga tcctccttta aactattaca taattatcct 2094841 aacagatcca ttgttcattg taaataatgg aatacgagtt ttatattata aaagcctctt 2094901 tttgatctaa ttttgcacta ttttctattt tctatctgaa gttaatgttt agtcgaagaa 2094961 atcctgtcaa aaaagcgcct gtataaaaac cgagcattcg cagtctcttt tcttttgtca 2095021 tgaatcgaaa tggacaagca tactatggta taaaatttcg tatgcgggag gaaaagcgat 2095081 gaagcgtctc accttagtat gcagcattgt ttttatactt tttattcttt tttatgacct 2095141 taaaattgga accataccca ttcaggacct ccctgtctat gaagcatcag caaaaacggc 2095201 tgtacaagaa ccggcttata aaacggtgaa ggtaaagccg ggtgatacgg ttatgtcgat 2095261 agtcggatca gcaggttctc cggatgacat tgtaaaggat tttgaagcac tgaatccaaa 2095321 tgtgaaagct aacgccattc aagccggaac agcgtataaa ttcccggtct acccttaatt 2095381 taacgttaat ttcttgtcag ttcggcgaag acactgttac aatgtaattt gtaaaataaa 2095441 ttcacataaa ccatactaga attgttatat ctagaagcgg caactacaat taaggagcga 2095501 ttgcaagtga gtgaaatcac acatcgtaca aaaacgcgtc ccgtcaaagt gggaccttta 2095561 acaataggcg gcaacaatga agttgtcatc caaagcatga caacaacaaa aacacatgat 2095621 gtagaagcaa cggttgcgga aattaaccgt ttggctgaag ccggatgcca aatcgttcgg 2095681 gtagcatgtc cggatgaacg ggcggcaaac gccattgcgg atattaaaaa gcgcatttcc 2095741 attcctctcg ttgttgacat acatttcgat tataaacttg cgttgaaagc cattgaaggc 2095801 ggcgcagata aaatccgaat caaccccggc aatatcggcc ggcgcgaaaa agttgaagcg 2095861 gttgttaaag cggccaaaga caaaggcatt ccgatcagaa tcggagtaaa cgccggttca 2095921 ttggaaaaac ggattttaga aaaatacggt tatccgactg ccgatggaat ggtagaaagc 2095981 gcacttcatc acattaaaat tcttgaggat cttgattttc acgatattat tgtcagcatg 2096041 aaggcctctg acgtgaacct tgcaatcgag gcttatgaaa aagcagcgaa agcgtttgac 2096101 tacccgcttc acctcgggat caccgagtca ggaacactgt ttgccggcac agtaaagagc 2096161 gcagcaggac tcggcgccat tttaagcaaa ggcatcggga acaccatgcg catttcacta 2096221 agcgcagacc ctgtagaaga ggtaaaagta gcaagggagc ttctgaaatc tttcggctta 2096281 gcctccaatg ctgccacgct catctcatgc ccgacttgcg gccgtattga gattgatcta 2096341 atcagcattg ccaatgaagt ggaagagtat atttctaaga taaaagcgcc gattaaagtt 2096401 gctgttctcg gctgcgctgt aaacggacct ggtgaagcga gagaagctga tatcggaatc 2096461 gccggcgcac gcggtgaagg gctgctgttc cggaaaggga aaattgtccg taaggttcca 2096521 gaggaaacga tggtagaaga actcaaaaaa gaaattgaca ttcttgctga ggaacactac 2096581 gcaaaacttg aagctgaaaa agcaaaatta aaagaagaaa cacaaaaagc ttgacgggaa 2096641 cccgtcaagc ttttttgtgt tagaaaaatg gaataataaa tattccaagc actaatgaaa 2096701 cgacaccgat acccattgcc caggctccaa ggccttgagc acctcttctt cttgcgatat 2096761 agccgacaat aataccagca gctcccaata aaacaggcag tacaaacaat gaaatgatgg 2096821 acaaggctaa agcgatgtac cctattcccc gtccttcatt gacattgccg ccgctgcgat 2096881 cattgtcttg gtcattgctg cggtcagcag cacgataagg ctctgcgatt tcagcagctg 2096941 tttcctcaaa aaaaccgtca ttgtcgcggg taatatttgt cccttcagat ccatgatcaa 2097001 catagtaact gttgttatca cgcttttcgt aatcgtttgc caccttcaat tcccccttct 2097061 gttttattaa aggagctttt atagtttgat ccattttgcc tgattcatgt ttgctaaact 2097121 tttctgttaa tgtcaattgt ttatgttaca cttgaaggga tgaaactgaa ggagtgtggg 2097181 catgttacgc ttaggaatag atattgacgg cacaatcacg gctcaggata cattcgtccc 2097241 ttatttgaac cgttcgttta atctttccat ttcattaaac gatatgacgg attatgattt 2097301 aacaaagctg ttaaacatta cccaggaaga attttgggat tggatgaatc aaaatgaagc 2097361 gatcatatat aaggaagcat tgcttgcaca gcatgcgaaa cagtctctcg atcttctcaa 2097421 agaggagcac aagcttattt atattacagc gagacggact catttaactg atattactta 2097481 tgaatggttt gacagacaaa acattcatta tgaccacatc gaacttgttg ggggtcatca 2097541 caaagttgaa gcggtcaaga atcataacat cgacctgttt tttgaggatc atcacgggaa 2097601 cgccatgatg attgcgaaag aagccgggat accggtgatt ttgttcaatt ccccttataa 2097661 tcagcttccg attgattcaa acatcatcag agtaaacaac tggctagaag ccgttcaatg 2097721 gatgaacaac aacaagcatc acttaatacg cgtcaataac tgaaaaagga gcccaaaccg 2097781 ggcccctttt tcatatatac gcattttacg cagtagtgtt ttcttggttt tccgctgtac 2097841 aatcagggca tgtgccataa atctcaaatt tatgcccgct gacctgatag ccatccaaat 2097901 catcacaaag cttgtccatc ggacatgatt caatttcctt tgttttgccg caggcaagac 2097961 aaataaaatg atggtggtga tgggtgaatg aacacttaaa tcggaagagc ttttcaccgg 2098021 acagctcagt tgtttccaaa atcccaagtt cttcatataa agaaagattt ctgtagattg 2098081 tatcaaagct taagcctgga taatcatcat tcagtgcaga cagtacgttt ttagcggtaa 2098141 gatatctgtc tgaatcagca aaaagctgca gcatatcctc ccgtttgttt gtatatttat 2098201 atccgttttc ttttaatagg ttcagcgctt cttggacgtt catgaagggt cccccttttc 2098261 gctttgctta agaacgtatc acatgtatga aaaagaaaat ggcagctgtc tgtccagcaa 2098321 gccattttct ttactgcaga taaaattata cccataaaat gaataaaagt aaatgaaagc 2098381 ctagtggatt gcgtttttga attttccgcc tctcgtttca tgagtattca taattgttat 2098441 gaatgcattt tgatcaactt caaacacgat cgatttgagc tttgtcactt ccagccttgt 2098501 gacaaccgcg taaattacgt ctttttcttc gtccgtatac ccgcctttcc ccttcagctt 2098561 cgttgtgccc cgaccgagac ggtgcaaaat cgcgtcggaa atctcatcat actgctcaga 2098621 cacaataatg acagcttttg tttcatcaag cccttggatc acggcatcaa tcgttttcat 2098681 cgcaatataa taagtcatga atgagtacat cgcttgctca ggaccgaaca caaaaactgc 2098741 ccaaatgaaa atgaacacat tgatgaacat aacgaactca cctacagaaa acgggagttt 2098801 tttggtcagc aaaataccga gaatttctgt accatccatt gaacctccat ttcgaataac 2098861 aagcccgacg ccaaagccga gtaaaagacc tccgaacaca gtagccaaaa taggctgggt 2098921 tgtaatggct tctacatggt gaagtgagga ttcaataacg gcaagcccga caatccctat 2098981 aaacgtagag actagaaagg tcttaccgat atatttatat ccgaagatca taaaaggaat 2099041 atttaatatg acaacgaaaa aagcgaaatt cagaaagggg tttgacataa agaggtggtc 2099101 taaaataaga gatacaccga taatcccgcc atcaataaaa tcattgggga ttaaaaataa 2099161 ttcaatactt acagccgcag atgcagctcc taccagaatc ataaagaccc tgaaaataaa 2099221 atgggtaaat gtttctttct tatgttgttt tgttggggtc ataaaatctc ctttcctgca 2099281 ataactattt taaatacatt ataaatctat tttaccatta aacactgaca cattttactg 2099341 atttgcccat acattaagtc tggaggtgga atgaccgatg attttatttc aaagaattat 2099401 tttgcagcgg cttaatcagg ctactgctga tgatttgctg aagtactcaa aacaatacgg 2099461 aatcagctta acaagatcgc aggccgttga agtagcgaac ctgttatacg ggaaaaatgt 2099521 aaacatcttt aatgagagtg aacgaatgcg gctgctgaaa caagtagaga cgattacatc 2099581 gaaagaaaca gctcaaacag ttaatgaact attcaaacaa tttacaagct aaaaaatggg 2099641 ggtgttatcc cccatttttt attgctgtaa aatcttttca agcaatgtat catcaaattg 2099701 tttttctttc agcatttcaa tctcaaaacg gtatggcggt tttttgttct ttttatcttc 2099761 accgacgtat ggtgtttcaa gaatttttgg aatgtctttt aactgctcat ggtgaacaac 2099821 atattgcagt gcgtcaaaac ctatttcacc aaagccaata ttttcatggc ggtcttttct 2099881 cgcacctttg acatttttgc tgtcattgat atgaagcact ttaatacggt caatgccaat 2099941 gattttatcg aactcattta gcactccgtc aaagtcttcg acaatgttat acccggcatc 2100001 atgtgtatgg cacgtgtcaa agcacactga cagctgctca ttgtgtgtaa cgccttcgat 2100061 aatctgcgca agctcctcaa agcttctgcc gcattctgat ccttttccag ccattgtttc 2100121 taatgcaatc tggacatttt gattcggatc aatcacttca tttaagcctt caataatttt 2100181 tttgatgccg gcttcagctc ctgcccctac gtgagcgcca ggatgaagga caatttgctt 2100241 cgctccgatg gccgctgtcc gttcaatttc tgaacgaaga aaatcaacac ccagctcaaa 2100301 agtggacgga tttgtcgtgt tgccaatatt aataatataa ggcgcgtgta cgataatctc 2100361 gtcaatgccg ttttcttgca tatgtgcccg gcctgcttct atatttaagt cttcaatttt 2100421 ctttcggcgc gtattttgcg gtgcgcctgt atagatcata aacgtattcg ccccataaga 2100481 gactgcttcc tggcttgcag ccagaagcat atgttttccg ctcatagaga cgtgtgagcc 2100541 tattctcagc aacaggttcc cctactttct tttcttagat tggtttcttc tctgtttttt 2100601 cttgattttc tccatctcat agctcatttt ctttttatac ccaggcttaa ccttcttcgg 2100661 ctttttcacg agacgatgag caatttcatc cgcttcattc ggcgtttttt tacgtttttt 2100721 gcggcgctga cggtcatcgc cttttttcca ttcgcccttt tcaagctcta agtactcaaa 2100781 ttcgatgccc attttttcaa gtcttactaa tgcatcctca tcagtaagct cataaatggt 2100841 catcgcttgt cctgatgagc cggcacgagc cgttctgccc acacggtgaa catagaaatc 2100901 gagatcatcc ggcagctcat agttgataac atggctgaca cctttaatat caatacctct 2100961 tgcggcaagg tcagttgcaa tgatatatgt gaattccaaa tcattgatct gcttcatgac 2101021 ttttttccgc tcacgtggtg ttaatccgcc gtgcagcaag ccgattttca tgcctttgcc 2101081 agtcagatac tgggcaatat ggtcagccgt atttttcgtg ttggcaaaca caatccccag 2101141 gtatggattc agatgcgaca tgatgtcaaa aaggagcttg tccttgtcac gatgtttcga 2101201 aggaatgagg atatgctcga ttttcgcagc agtcacctgt tttggctcca catgggcgta 2101261 tttcggattt tccatgtatt tcttcaagaa tggtttcagc ttttccggta tggtcgctga 2101321 gaacacaagc atttgcagat cctcaggcat gcgggaaccg atgtaatcta catctgcaag 2101381 gaatcccatg tccagcatta aatccgcttc atcaataaca agagattccg ctttatgaac 2101441 acttaacgcc tgttctttga ttaagtcagc aatccgtcca ggtgtaccga caacaagatg 2101501 cggctgtatt ttcaatttat caattgattt ttgtttatca gtgcctccga taaaacattt 2101561 cgagcgaatc tgacttcctt cttcaccctg cgtgatttta agcgcttcct gataaatctg 2101621 gttggcaagc tctcttgtcg gagccgtaat gactacctga acgacatcct tagcaggatc 2101681 gattttgttt aataaaggca gtaaataagc gtgagtcttt ccagtacccg tctgagactg 2101741 gccgatgacg ctttcttttt ttaacactgc aggaatcagc cttttctgga tatcagtcgg 2101801 ttcgtaaaaa ccaaggcgat gtactgcatc tataataaat ggtttcaatt cataaagttc 2101861 aaatttcgtt tctttcattt ttcccagctc cttaaagcgg cacattatgt gtccatcatc 2101921 acattatacc cgattttgct taaaaacacc acgtttgcaa ggcgtttgtt ttattcagtt 2101981 atgtaaagca aataccgcag cccatgcata ttctaatagc agagagagct gaaaggaggt 2102041 acaagtatgt tttcaccgca gcagccaatg agaaattacc cacagcccgg accgccccgc 2102101 cccatgccaa atcagcgaat gatgggcaga agaccgccta atatgcgagg accttcattt 2102161 ggagcacagc agcaaggttt tcagcaagcc ggacaatttc ttcctcaggc aaatgccgga 2102221 gcgagaaatg gtgcaggtgc aggcggaggc ttaaaaggaa tgctgtcaag gttcctcccc 2102281 ggcggaggag gcgctggcag cgccggggtt cccggaattc caggagcagg tgcagcagcg 2102341 agcggaggtg ctggcctgca aggcattcaa aatattgcca atcctgcatc attatccagt 2102401 atgcttggaa atgtgcaaaa agtactcggc atggcgcagc aagtcacccc tatgatccag 2102461 cagtacggcc cattagtccg caatctgcca gcaatgatga agctgtacag ccaattaagt 2102521 aaaagtgatg atactgagac agaggccaat gaggaaagtg aaaaacaatc cgtttcagaa 2102581 gaatcatcag aaaaagaaaa agagactgaa acaaaaacct cagatgggaa caaaaaatca 2102641 aaaccaaaaa gttcttctct cccaaagaaa tctaaaacaa ctgacaataa agaacaagaa 2102701 ttaaaaacat ctgccccgaa gaaaaaggaa gctgcctctc ctgctccgaa aagaacatca 2102761 ggcagttcaa aaccgagatt atatatttaa cattctttga tatcttaagt gagattggct 2102821 ataatgagat cagaagaatg caagaataga gccgtttgat tacggctttt tatattgcct 2102881 ttactcactt cagtattgga ggacaaccga aaatggacgt aattaaaatt tcaccgcgcg 2102941 gctattgcta tggtgttgtt gatgctatgg tcattgccaa aaatgcgtcg ctagataaaa 2103001 gcttgccaag acccatctat atactcggga tgattgttca taataaacac gtcactgatg 2103061 cgtttgaaga ggaagggatt tttacattgg acggctctaa ccgtctggac atcttaaagc 2103121 aggttgacaa aggaactgtc attttcactg cgcacggtgt ttctcccgaa gtcagaagaa 2103181 tcgcagaaga aaaagggtta gtcgcaattg atgctacatg tccggatgtg acaaaaactc 2103241 ataatctaat cttagagatg aaagaaaaag gatatcacgt gatctatatc ggcaaaaaag 2103301 ggcatccaga gcctgaggga gccgttggcg tagcgccgga gatcgttcac ttagttgaaa 2103361 cagaagaaga tgtaaagaac cttgatatcc aatctgagaa gttaatcgtg acgaatcaaa 2103421 caacaatgtc tcaatgggat gttcacgaca ttatggagct tgtcaaagaa aaatatcctc 2103481 atgtcgaata tcaccaagag atttgcctcg ctactcaagt gcggcaggaa gctgtatcag 2103541 agcaggcaaa aaaagcggac ttaacaatcg ttgtcggaga cccgaaaagc aacaattcaa 2103601 ataggcttgc tcaagtgtca gaggaaatag ccgggacaaa agcataccgg atcggcgact 2103661 taagcgaatt gaagctcgaa tggctgaaag gcgttaatac cgttgcagtt acagcgggag 2103721 cttcaacacc gacgccgatc acaaaagaag tcattcgctt tttagagcag tttgatcacg 2103781 aagatccatc aacttggaca actgaacata atataccgct caaaaaaata cttccaaaag 2103841 taaaagcaaa aaactgaggc tgtaaaagcc tcagtttttt tatagaaatg taaatggatt 2103901 tgtatctgtt tcagaaacaa agatattcac gccaaacttt ttatcattac acattgatgt 2103961 aagttttctc gtgacgcctt ctttcatgat tttttccgcg taatggcccg gatcaaccac 2104021 atttaggcca agcatcatcg catcatgggc cacatggaag tataaatctc ctgtgacgta 2104081 aacatcggct ccctttcgtt ttgcatgatg aatatacttg tttccatctc cgccaagaac 2104141 agctactttt ttcaccatgc tgtcagcatc cccaaccatt ctgacaccat tgacgtcaag 2104201 cttgtctttc acaaataaag cgaattcctt gagcgtcatc tcatttttaa gggttccgac 2104261 acggccgagc cctttttcgg cgggagtctg ttcgacagga tagatatcgt aagcgacttc 2104321 ttcatatgga tggcttttta tcattgcatt gataacagcc ttttcgacgc ttttaggaaa 2104381 tacagtctca agccttactt catgaacaag ctcaagctct cccacttcac cgataaaagg 2104441 cttagctccg tccaatggct taaagctgcc gattccttca gatgaaaacg cgcaatggct 2104501 gtattcaccg atatggccgg cccccgcatt tccgagcgcg gctctgacct gctcttcata 2104561 ttccttcggc acgtaaactg ccagcttttt cagaggatcc gtataagtag gtgccagcac 2104621 ttccgtctca ctcagctcta atgcttcagc aagcaaatca ttcacaccgc cgtccgcaac 2104681 gtctaaattt gtatgagctg cataaacagc aatatcatgc ttcaaacact tttcaattaa 2104741 ccttccggca ggctgatctg ttgaaatatg ctttagcgac cggaaaattg gtggatggtg 2104801 tgcaataatc aagtcaacct ctttttcaat cgcttcatcg ataacgctct ctaacacatc 2104861 aagtgtaacc atcacatttt taattggttt gtttaaggtg ccgatttgca ggccgatttt 2104921 atctccttca accgcatagg ctttcgggga aaattgttca aacagctgga tgatctgctg 2104981 cccatttaca cttttagcca tgatcgatta cctcctttaa cagctccatt cgatcggcga 2105041 gctcctttaa tttttgtttg ttttgctctg tatccgccgc ttggctgatc tgttcataaa 2105101 tgctttgagt gtgctgaagc tcttgtgtcc actttttcaa aaagacagca tttttttctt 2105161 ttgccaagaa agggccaacg agcatcccgg ctgataaaga aataccgtca taagccgcat 2105221 ccctgtctcc cgcttctgcc accagcacct catagcactt tccgtcctct tcaaggatta 2105281 cctcatctat cagcgcatat ctttctttat aaagccactc cctgatatga acagcatgaa 2105341 tattcggctg taaaatgagc cgttccttcc ccgttaattt gtctttgccc gcttctaaaa 2105401 tgtgagcgat caaagccccg cccattccgg caatcgtaat ggcatcagct tcaccttttt 2105461 taatcacttc cagtccgtct ccctgcctta cagaaatgtg cgagtttaag cctgattttt 2105521 caacctgccg ctttgcagac aaaaatgggc cgtctgttat ttctccggca atcgccccgc 2105581 tggctttatg attcagcacc gcataacaag gaaggtaggc gtggtcagag ccgatatcgg 2105641 ccatcaccgc tccattcggt atgtactccg ctactgtttg caatcgttta gataatttta 2105701 attcgttcac ttgtcatcac aacttttctc aatcattttt tcctttacta tcatataaaa 2105761 aatcagcccg gaatccaagc tgaagcaaat gattttgaaa ttatttcttt tgatgcgggt 2105821 ctgcacgcag cagtcaaaaa taaaaggctg tcgagaacat ctcggcggcc tgtgaatgta 2105881 taaagagaaa aatagttctt ttatttaatt tttgacaccc actctgccat atcatccagc 2105941 ttatcggccg gaacaagacc ggaaggcatt ccattaccgc ctttttcgat ctttgtttta 2106001 atttcagcga catctttctt atcccctaca ccttttaagc taggacccga aacaccttca 2106061 taattttcac cgtggcatgc gatgcagttt gccttgtaaa tttcttctgg tgaagcgttt 2106121 gcatctttct tttcagcaga tttgctttct cctccgctcg caatctcccg agagtcatca 2106181 agtcctttta ctgataaaaa gaaagttaga ccaattccta aaacagcgat cagcaaaaat 2106241 ggaataagcg ggttccattt catttccctt cccccttttt gatccttccc cctatgtaaa 2106301 cacttctaat tctaacttat ttttacaaaa agtaaatgga ttgctataca aaagtttttt 2106361 attcacactt tatacaaaat tgaatagaaa catgcctaaa tctctaatat cctttttatt 2106421 ctattgtata atgtattgta tacgcttaca atagaaaata tggaattaga ttttgaaatt 2106481 tttcaccaca atgttcattt gcaaatgaca tcatttttca gtaaaataaa ggcatattat 2106541 ccatatatct ttttaaaaaa agaagaacgg atcttcaaga cccgttccat cttattcaag 2106601 gaaatctttc aaacgtttac ttctgctagg atgtcttagt ttccgcaacg ctttggcttc 2106661 gatttgtcga atacgctctc tcgttactcc aaatactttg ccgacctctt ctaatgttct 2106721 tgtacggccg tcatcaagac cgaatcgaag acgcaataca ttttcttcac gatcagttaa 2106781 cgtatcaagc acatcttcca gctgctcttt caatagctcg tatgcggcgt ggtcagaagg 2106841 tgaagttgct tcttggtctt caatgaaatc accaaggtgc gagtcatcct cttcaccgat 2106901 cggtgtttcc agagataccg gctcttgagc aatctttaag atttcgcgta ctttttcagg 2106961 cgttaaatcc atatcttccg caatttcttc aggtgttggt tctctgccta agtcttgcag 2107021 taattgacgc tgcacacgga ttaatttatt aatggtttca accatatgaa cgggaatccg 2107081 gatcgttctc gcctgatcgg caatggcgcg tgtaatcgcc tgtctgatcc accacgtagc 2107141 atacgtactg aatttataac ctttgcgata atcaaatttt tcaacggctt tcatcaggcc 2107201 catgtttcct tcctggatca gatcaaggaa cagcataccg cgtccgacat accgttttgc 2107261 gatactgaca acaagccgca ggttcgcttc agccaatctg cgtttagatt cttcgtcacc 2107321 ttcttcaatc ttttgagcgt aggcgatttc ttcttttgca gaaagaaggt taacccgacc 2107381 gatttccttt aaatacatac gaactgggtc attgatttta acgccaggcg gtacacttag 2107441 gtcattaagg tcaaattctt cttcggcttt ggcaagctgc tgaatattag gatcttctgt 2107501 ttcttcattc tcactaatta attcaacacc ttgttcacct aaaaattcat aatactcatc 2107561 catttggtct gattcaattt caaagctgga catacgctca gcaatttctt catatgtcaa 2107621 aacgccacgt tttttaccag actctgttaa ttgctctttt acttggtcga atgttaattc 2107681 tgtctcgtgg gtttgtttat cagccattat ggatccctcc ttccaaagct tgcaacgaat 2107741 tctataagcg gtatgattct tattcggtcc attcaggcgt tttctatgtg aactgccttt 2107801 aacaatgtgc gaataatgaa atgacaattc atgatgaggt taagcgatct atttgctcct 2107861 ccgcaaggaa tcattgccaa taaatgctcc tcatcagttc tccagttatt ttaaagatcg 2107921 gttcaatgta acgatttctt gagccaaaga agcagctctt aaaaaatctt tttgcctttc 2107981 tgcttcggct ctttccgcct ctttttcttt tatcattgac caatttcttt gattcaacac 2108041 tttttttaca taatctgata actcggcttc gctaagctct tgattaacct gaagcattaa 2108101 tatatcggac aagagctggc ttatatgatc atccgtcacc ctggccatca gatgctgagg 2108161 cgtcagctcg gctccctctt cataaaaagc ataaagataa gcggctaatg cccggtgctc 2108221 atcaatatta aattgaaacc ctacccggtc aatcactttt ttgatgacgc tccgatctcg 2108281 aagcatgtga gcgagtaaca gcctttctgc attttcatac gccggacgca aacgtttttg 2108341 ccttgctttt gtcgtcagat gcgctcgccg cgttttagtt tcaccgctat tgtcagcagg 2108401 tttgttttgc ttgctgaaaa cagacagctg ctcagttaaa gactcctgtg aaagcgaaaa 2108461 ctctgaagca agctgcttta catagacttc ctgctctaga gaccctgaaa gcgtgctgat 2108521 ttctttcagt acgtctttaa tgtaagctag gcggtcgcct tcatcggaca ggttctttcc 2108581 ttttcggaaa tattgcattt tgaacgccat tacggtgaca cttgcgtcaa taatgtcgtt 2108641 tttaaatttt tccccgccga attttttgat gtaatcatca gggtccaatc cgtcaggaat 2108701 cattgcaact ctgactttgc agcctttttt ttgcagaagc tccgaagctt ttaaggtggc 2108761 ttcataaccg gctttatcag agtcatagca aagaatgatt tcttcgacgt ttcttctcag 2108821 gatcttgaca tgatcatctg taagagacgt tcccatcgtg gctatgcttt cctttacatc 2108881 cgagcttacg gccgatatga catcagcaaa cccttcaaat aagactgctc tttcctgctt 2108941 tctgatatga aggcgggcct tataaaaatt gtaaagcagt ttgcttttat gaaagagcgg 2109001 ggtttcagga ctgttcatat acttaggctg ctggctgcca agagccctgc ctgagaaagc 2109061 aacaacagcc ccgtgatgat catggatcgg aaacatgaca cggtttctga agcggtcgaa 2109121 atatccgctt ccgtcttcgc gtctgatcag gagacccgct ttttccattt gcgcctcact 2109181 aaatcccctc tttacaagga atttcgtgat aaagtcccaa gaatcaagag catagccaat 2109241 ctgaaattca ttaatcagct ctttcgtaaa gcccctagaa agcagataat ccagtgcctc 2109301 ttgaccttct tttgtattta ttaacaaatg atggtaaaat ttcttcagga gctcatgtgc 2109361 ctcagccatt ttttgttctc cagaagactc tggccgggct ccggaatgga ctgttatatc 2109421 atctggaaaa tcaatttggt atttgtcagc aaggtgagaa accgactcgg caaaagaata 2109481 gccttccatc tgccttaaaa aagagaaaac attgccgccc gctccgcagc caaagcaatg 2109541 aaaaatctgt ttgtcgggcg atacggaaaa cgaaggtgtg ctttctccat gaaaaggaca 2109601 gagtccaaag tagtttcggc cttgcttctt taattgaaca taatcaccta tgacttcaac 2109661 gatatctgcc gacttttgca cctgatccac aatttcatct ggtatccgat ttcccatctt 2109721 ataacactcc gtcgtacatt attcgatgct ttagtgcaaa atcccttcat cgttcgacag 2109781 gattttttgc agcagtgtaa taaatcgttc tcgatcttct ttattcaatt ttttaggccc 2109841 tttggcatat acgccttttc ttctttgttt gccggaaaaa tgacggccct ctagggcaaa 2109901 atcaatcgtg tcttccttgt aaagacgacc tctttccgac ataacagaga catttctgtt 2109961 caacagcaga gatgctaatc cgatgtcctg cgtcacaaca atatctcccg gtttcacgtg 2110021 atttgcgata tataaatcag cagcttcttt atgaggatca acatacttcc atttttcttc 2110081 attgcttctg gaaagctgat aatgttcaaa tgaagcgaca aaaagaactt gaacttcata 2110141 ctcggatgct gtttgtaaaa tttcatcttt taccggacaa gcatcagcat cgacaaaaat 2110201 cgtcttttct tgttcattaa gaagagtaat tctccatccc tccattaaac tcctgcataa 2110261 aagcaagcaa aatcgcacat cctttattat tgtggatgta tatgaatttg tcgaaaaatt 2110321 tccgggagaa attcttgaca tcttacccat aatagtttat tcgtatcaca cgatccttaa 2110381 acctaaaatt aatcatttta tcacaatttt ttattataat acaaacttca caaagatgct 2110441 attgtttttc attattccct tttggcacag ccaaaaaccc aggatagagc gtcctgagtt 2110501 atatgttttt tgttttgaga tgatggataa tatttgctgt ttcctcaacc gctttatttg 2110561 aaacatcaac aacctggcag ccgatccgat ccacaatctt ttcgaaatac tcgagttcct 2110621 ctttgattct gttgatattt gcataaatcg ctttatcatt aagcccgagt gattttaaac 2110681 gttcttttct gatatgattc agtttatcag ggctaatctt taaaccgatg cattttttcg 2110741 gatcaacgtt aaagagttct tccggcggat caacctccgg tacaatcgga acattggcaa 2110801 ccttcaggcg tttgtgtgcg agatattgag acagcggtgt tttagacgtt cttgacacgc 2110861 cgatcaaaac gatatcagct tttaaaatcc ctcttggatc acgtccatca tcgtatttaa 2110921 ctgcaaactc gatggcctcc acttttttga aataatcttc atcaagctgg cgcacccgcc 2110981 ccggttcgta tttcgctgtt aaaccgtagg ctgtttccat tttatcaatc aacgggccga 2111041 taatatcata atataaaaca tttgcttttt ccgcttcggc tatcaaatat tctctgattt 2111101 ccggcaccac gagtgtaaaa cagataatgc cgccgtctgc ctttgcaagt gaaatcactt 2111161 cattgatagt gcctatatct tcaacataag gaattcttct tacatgagta tcatccgccg 2111221 atccgttaaa ttggctgagt gctgctttta ctaccaattc agccgtttca ccgacggaat 2111281 ccgatacaac atagatgatg cggttattca tattatcccc ccgttagttt gcaatcttat 2111341 aggatttcat tttcagataa actgacaagt attttggtca tatttgtttt tgtcactctg 2111401 ccgatcactt caaagccttt atcggtgtct ttgatgacag gcagtgcatc aatttgtttt 2111461 tctattaagt gctttgcaat gtccatcaca taatcctcgc gtctgcacac cgtaatgttc 2111521 ggcatccttg tcatgatgat gtgaacaggg accgatgtaa gctcctgctg gccaatgctc 2111581 gctctgagca agtcttttcg tgaaagcacc ccgactaaaa cagcatcgcg gtccaccaca 2111641 aacagagtac ctacatcttc taaaaacatg gtgcaaatcg catcgtacac agaaacgttt 2111701 tcgtgaatca ctacggggat agattgaaag tctttcacct gaagcttttt gagtttatcc 2111761 gccaaaagct gtgtgccggt ttttcccgta tagaaataac cgactctcgg gcgcgcctcg 2111821 aggaatcctg acatggtgag tatggctaaa tccgggcgca atgtcgccct ggttaggttc 2111881 agcttttctg caatatgctc ccctgtaatc ggcccgtttt cttttacaat ctgcaaaata 2111941 tgttcttgcc gtttatttag ttcgatcgta ctcaccacct tttcacttca tagctatgta 2112001 aagaaataac aatccatatt ataacgtaaa tatcttgtaa tcaaacaaaa aacttataaa 2112061 tggggaaaag acgattaccg atcacacagc aaccgccttt tctctcttta ttttacaata 2112121 agggcattca tattcgcaaa ggacttgatc tcatccgcca agcttaccat ttgcgctaaa 2112181 cgatttgcct ttaatgactc attatccgct ataaccattg tatgatcgaa gtaagcatcg 2112241 atcggttctt ttaaggctgc aagtgaagca agcgccgcct cataatcttt tttgctgaag 2112301 ttttcctgca gattttgctt cgctgtttgg taggcatcaa acagttttgc ttcgtattca 2112361 ttttcaaaca gatcaggctg aatgtctccg cggactcctt ttttgctgat agagatcact 2112421 cggcctaacg cttcggctgt ttccttaaag ccaggtgcac caagcttttg ctccagtact 2112481 tgtgctttat gcagcgcaga gtacggctca agctcagagc tttccagcac ggcgtcaatg 2112541 acatcatgtc tgatttgttc agcattcaag acatatttca agcgctgagt gaagaaatcc 2112601 agcagttcat tttctttatc ggtttgaacg aaagtaagca gctcttcaaa tgaaattccc 2112661 cagttgcggt caagaagaat cgcaacaata ccgcttgctt ggcggcgcag tccgtaaggg 2112721 tcctgggaac cggtcggaat tacgccgata gagaagaatg aagcgattgt gtcaagctta 2112781 tccgccattg ctacaacagc tccggtgaaa gtagaaggcg tttctccgcc cgctgatcta 2112841 ggcatataat gttcattaac tgccgcagcc acagcttcat cttcgccaag cattctcgca 2112901 tacttttcgc ccataattcc ttgaagttca gggaattcat atatcatatg cgtcacaagg 2112961 tcgaatttag aaatttcagc agcccgcttc acatgtttta atgtatcttc atcagcctga 2113021 agacgaacgg caagtttctc tgcgattgat gtgactctcc taaccttatc agcaagagaa 2113081 ccaagctctt catggaaaac gatattttca agcttcttca catttgcatc aatgtttagt 2113141 ttctgatctt ctttgtagaa gaatgaagca tcagataaac gtgcgcgcag cactttttca 2113201 ttgcctcggg ccacattttc aatcgcgtgg ctgttgccgt ttcggactgt gataaagtga 2113261 ggcagcaggt caccgttttt gtctttgaca gggaagtagc gctgatgctc tttcattgtc 2113321 gtgacaagca cttcttcagg aattgacaga aactcggatt caaatgaacc gtaaagagct 2113381 gtcgggtatt ctactaaatg attcacttca tcaagaaggt cttcgtcaac tggaatgctc 2113441 caattgtttt cagcagccat tgtttccagc tgagattgaa tcatttgctt tcggacgcta 2113501 ggatcagcaa taacatgctg tcctttgagc tgctcttcat aagctgaagg tgattcaatt 2113561 gacacttcat gtccgaggaa acggtgtccc tgtgttgtcc gtccagactc aacgtttgtg 2113621 atcgaaaatg gaatgacatc ctgtccaaat aatgcgacaa tccatttgat cggtcggata 2113681 taacgcaaat cttcatttcc ccagcgcatg tttttcggga aatgcaagct tgtaattaaa 2113741 ccgctcaatt ctggcagaag cgacttcgtt tcttggccgg cttggaattt ttgcacgaat 2113801 acatactcta tgccttttac ttctttgatg tacaggtctt ccacatttgc gccttggcct 2113861 tttgaaaagc cgattgccgc ttttgtccag ttcccgtccg catcaagggc aatttttttc 2113921 gcaggccctt ttgcttcttc ttttatatca tcctgctttt ctgcgacatc cttaacgaac 2113981 acagcaagac gtctcggtgt attgaagagt ttcacttcac cgtgagtaat atttttttct 2114041 ttaagccagc ctgtcagctt gtcgccaagc tgaaccatgc tttcattcaa aaagcgcgcc 2114101 ggcatttcct ctaatccgat ctctaaaagt aaatcctgtt tactcatgag aagaaccctc 2114161 ccctttaagc attgggaacc ctagtttttc tcgttcctca tagtaggttt ttgctacttt 2114221 tctagctaaa ttccgcactc ttgcgatata gcccgtccgc tcggtaacag agatcgcacc 2114281 tttggcatca agcaggttga aagtgtgcga gcatttcagc acatagtcat atgctggatg 2114341 aacaagtccg ttgtccattt gcttgatcgc ttctttttca tatgtgctga acaattggaa 2114401 cagcatatcg acgtctgatg tttcaaacgt ataaacagaa tgctcatatt cagccatcat 2114461 gaataaatct tttactgtaa accctgacgt ccattccaag tcaaacacgt tttctttatc 2114521 ctggatataa gacgcgagac gctcaattcc atacgtaatc tctacagaaa cgggtttaca 2114581 ctctaatccc ccgacctgct ggaaatacgt aaattgtgtt atttccattc cgtcaagcca 2114641 aacttcccag cctagacccg cgcagcctaa agacggattc tcccagttgt cttcaacaaa 2114701 gcgaatatcg tgctcaagcg gatcaattcc aagagcacgc aaggaatcca aatacagctc 2114761 ttgaatgtta tcaggtgacg gtttaataat gacctggaac tgatgatgct gatacagtct 2114821 gttcgggttc tccccgtagc ggccgtctgc cggacgtctg gaaggctcta cataagccac 2114881 tttccacggc tcaggaccga tactgcgcaa aaatgtatac gggctcatcg tgccggctcc 2114941 tttttctaca tcgtaagcct gcataagcac acagccctga ctggaccaat gcttttgcaa 2115001 ggttagaatc atgtcttgaa tattcatttc aagcacctcc acttttcttt cataagttga 2115061 ctgcggcagc aaccaaaaaa ctcccgtctc tatgcttgcc agccgcaaac atagggacga 2115121 gagttctccc gcggttccac cctagttgct gagaacaaaa tcccagcctc ttttttaaaa 2115181 ttgctcaaga atgcctttcg ttgcgtgctc atccttagct tacaccgccc taaggtcgct 2115241 ttcatgaggt aaacgcaagt acttctttct ctcactgcaa catattttat aataaatgat 2115301 catataaaaa gatggaccaa atgtcaactt ttgttttcac ccataagatg tttcatgctt 2115361 tccatttgat ctaaaaagcg ctttgatttt aaatacaatc ccgaatattc ttcgtaatat 2115421 aaatcaatca cttgctttaa ttcagctttt gtttcctctt ttaaggacac attgccgagt 2115481 ctcgacagat caaaatagta aaagagcctt aacagccttg ccgtttgcgg tttaatcggt 2115541 atcctgtaag gatctttttc aaaacagcgg tggcatataa aaccattatc acgaacagag 2115601 aaatgaaagg ttccgtcttg gcttttacaa tgtacacaat gattcagctc aggatacagg 2115661 cccatgacac cgagcatctt catttgaaca atgaaggtga taacatccgg atctgttcct 2115721 tcattcaact gttttaatga ttctaatatg aattcaaata aataaggatt tggctttttt 2115781 tcttctgtgc ctctgtcgac taactcagca acataggcag catatgctgt taaaaacaag 2115841 tcttccctga tgcctctcat gctgaggatc atttccccct gctgaagcgt tccgaggccc 2115901 gatgtttttt gcattaagaa agaaccatac aaaaagggct ggctgactgc tgataaacgg 2115961 ctgttcggtt ttttggcgcc tcgtgccata acacctattt ttccgtgttc tcttgtcagt 2116021 aatgttacga ttttattcgt ctctccgtaa tcatttgtgc gaagaacgat cccttcacat 2116081 tttgtcagca tttccgcacc ttcctcaagc aggagcggcc aagaggttta taaaattgga 2116141 taatcaaatc gggctagctc atcttctagt tcttcgggtc tttccatgtt ctctttttcc 2116201 agttctttaa aaagaagata cgtatcaaca tttcctgttt gagaaaatac gttccaggta 2116261 aaattcaaca caagaaaccc acctttctgt agttaaacta gcttacctaa actccaaatt 2116321 cttaccttta tcttgaccag atgtcctcca tttcatgtta aacaaaattt gctaatgtat 2116381 ccctgttcct gtgagataat gacacacacg ggaagagatt aatattcgtc ctctttaaag 2116441 ccaaaatcgc gaagctggga cattttatta cgccagtctt tctgcacttt cacccacaat 2116501 tcaaggtaga cacgggagcc caacagtgct tcaatatccg ctctcgctct ttttccaacc 2116561 tcttttagaa ggcttccttt tttaccgatc acgatgcctt tctgggaatc ccgctcgacc 2116621 acaatcgttg ccgctacgtg cacagaaccg ttgtcctgcc ctttgatgga ttcgatggcc 2116681 accgcaatgc tgtgcgggat ttcttctctc gtcaaatgca gcaccttttc cctgattaat 2116741 tcagaaatga taaatcgttc agggtggtca gttacctggt cactcggata gaattgcggc 2116801 ccttccggca aatacgcttc gatctgcgcg agcaaggttt cgatgttatt tccttctaaa 2116861 gcagaaatcg gaacaatttc cttaaaagga taacgtttgc ggtattcgtc aattagcaga 2116921 agcaattggt cgggatgaat tttatcaatt ttgtttacga ttaagaatac aggcgtagac 2116981 atcgtctgca atttctcaat gatgaattcg tcgcccttcc cgtagccttc ctcagcattg 2117041 atcataaaca agatcaaatc gacttctttt aatgtatttt gcgccacttt catcataaag 2117101 tccccaagtt tatgcttagg tttatgaatc cctggtgtgt caataaaaat ggtttgtgat 2117161 gtgcctgtcg tcagtactcc ttgcaccttg tttctcgtcg tttggggctt atcgctcatg 2117221 atcgcgattt tttgtccaat gactctgttc aaaaatgtag attttcctac gtttggtctt 2117281 ccaataatgg atacaaatcc tgatttaaag ctttcgttcg tcatgtaaat cctccgatga 2117341 aaatgcgcct ggcaataatt cttccacagt catttctttt atttgtcctt gtaaattagt 2117401 cagtacgaca ataacgtctt ttgtgcaaag ctcagaaatc acctgtcggc aggctccgca 2117461 cggagatact ggtccagggg tgtcagccgc aacggccagc atctgaaact ctgtatcccc 2117521 ttcagaaaca gctttaaata aagcggtacg ctcggcgcaa ttgcacatgc tgtatgccgc 2117581 gttctcaata ttgcagcctc tgtacacttt tccatccttg gtaagaagag cggctcctac 2117641 ttggaatttg gaatacggcg catatgccat atcacgcgct tttaaagctt ctgttattaa 2117701 ttcttgtctg ttcatgtgta cattcctctc ttacctataa tggtaccgct atcactttat 2117761 attttacata atcgcgcgct ttttttcacg cccatttcta aaaatgtaaa ataaatgtaa 2117821 gaattttcag ccattacagc tttggcaaaa aaataagtaa accaatgata cacgaaatca 2117881 cggcaaaaac gcaaacagcc ccggcggcag cgtccttggc cgctttagca agagggtgat 2117941 gtttgtcagt tattaaatca accgtatgtt caatggctgt atttaaaagt tcaagcgaaa 2118001 acataccacc tatcaaaagg aatataatca tccactcaat aatgctgagc tctacaagga 2118061 agccgcaaat gagaacagcg caggcggctg cggcatgaaa ttggaaattc cgctccgtcc 2118121 gcgctgtttc ccatatgccc cggcctgcat gcacgaagct tttgaagaat cgattcagct 2118181 catttctatg atcttttgag tccataagcg tccagcaatt ccttttgctt agtaaacatc 2118241 tcctcttctt cctctttcgt catatggtca tatcctaaaa ggtgcagaaa tccgtgtaca 2118301 gctagaaatc cgagctctct tttaaaagaa tgattatact cctctgcctg ctctcttgtg 2118361 cgatcggcac tgatgataat atcacctaaa accggaggca tttcggcgcc cacgatttcg 2118421 atctcgcctt ctccctcttc ttcaagagca aatgagatga catctgtcgg agcatccttt 2118481 ccccggtatt ctttgttaat ctgatgtatg tcatcattgg aaacaatcgt gacagaaact 2118541 tcagcctgat cctgaacgcc ttcacgctca gcggcaaatt gaagcagatt ttctacttct 2118601 ttgagcatct cttctgagac gcttcccgtt tcatcaacga tatcaatcag taaactcatc 2118661 tatttcacct tcttagtagc ctccggatat tcaatccggg agtggaaaat tccttttaat 2118721 gttgcacaga gcgtttttgc gattgtatcc agctctttaa atgtcaaatc gcattcactg 2118781 aactgtccgt cctgaagctt atcggatata ataccccgga caagcttttc aattcgttca 2118841 ggatttggat tgtgcatgga tctgacggcc gcttcaacac tgtcggccac tgatataatt 2118901 gcggcttcct ttgactgcgg cttcggtccc ggataacgga actcttcctc tgtaatctgg 2118961 tcgccttttt ccttcgcttt atagtaaaaa aactttaaaa gcgaggttcc atgatgctgc 2119021 tcagcaatat cgacaagctc tttcggaaat ttatagcttc tcagcatatt cgcaccgtct 2119081 gtcgtatgcg agataataat atttttgctc aactgaggtg acagcttgtc atgcggattg 2119141 tcaatattca tttggttttc aataaaatat tgcgggcgct ttgtttttcc gagatcgtga 2119201 taatatgcgc cgactcttgc aagcaaacca ttagccccaa ccgcttcaca ggctgcctct 2119261 gataaattgg caaccattac actgtgatga tatgtacctg gtgtttccgt cagtattttg 2119321 cgcaatagcg gatggttagg attagacagc tcgagcagcc tcatggtgga taaaatgcca 2119381 aagcccgtct caaaaaacgg catcagaccg atgatcaata cagatgaagc aaaccccgac 2119441 acaaccccca tgagcattaa cgtgccgatt tcaagacccg acagcgcagt gttctggatc 2119501 aataataagg atagaacgac aaccatatta ataaacgcca cgaaaagtcc ggtctgcaaa 2119561 atctttgatc ttgcattgtg ttttcctaaa aataatacac ctgaaatgcc gctgatcaaa 2119621 taataaatcc ctatgacata attgaatgtt cctgtcacac cctgattaaa catcatactt 2119681 ccgcaaatcg caagaatgat acttcccaaa atggcaatgc gttcattcat cagcagtttg 2119741 attaagatgg cgccggccgc aatggggacc agatagccga tattattata ctccatcttc 2119801 tgaaacaaac tgacaacctc catgatcaca agcaaaagtg ttgtgattat ggagaataac 2119861 agaatggatt ggtttttaaa cttcagattt tgtttctgtt tttcaaaata atatacaagt 2119921 gttgcaatga aaagtccgat cataatcaat agcccgctga tcggtttaaa gagatttgag 2119981 ttatttaata acccggtcag ctcaagtttc ctgtacactt cccgatcaat gaggtcattt 2120041 tcttccacga gcacttgccc ctgtttgatt tgaacctgct ggacattatc tgaggcttcc 2120101 tgccgttttg cctctgttgc tttcggatcg aagacgtaat tcggaataat agcaaaacgc 2120161 ccgatttctg tcgcggctcc caagtattta gacggaatag aattgctctt tagctctttt 2120221 tctaccttat cctttgcatc agatagttta tccgaaggga tttcactgct catgaccgta 2120281 tttaccgcgg taatgaccgt atctctgaca aaagaaaagt cttcactgtc tgctttcagc 2120341 aatgtcttga tggaatcctc cgatatagaa tcattcacat ctgatgtcaa tttgtccttt 2120401 acagatttga ccattgattt ttccgatggt gatttactgc cttcttccga tgattttttc 2120461 acttcactaa tactgtcgaa tattgatgac acaaggtcaa tccgattgtc tgtatattct 2120521 ttttttaatg tatattgatc ttcaaccgcg tcctcagcgg cttgcttttt ttcctctgtg 2120581 gctttttgat cttctacggt tgccggagcg taaatggtct tgtcgctgac tgaaaacagg 2120641 tctaaatcaa gtgtttccgg cttaacatgt acaaagagca aagcaaacat aatggcagcc 2120701 agcagaagat acagcagtac atgcatggag cgggcatttt taaaactgct ccattttttt 2120761 gagctgcttt tggtcttagc cttctttttc aacacaagaa cctcctcttg aaacatcaag 2120821 cccataagca atcataaaaa tgacccgata acgcgcgatc gggtcattca gcattaattt 2120881 tgcttatcgt atgcttcaat aattttcgca acaagcggat gtctgaccac gtctgtctgg 2120941 tctagctcaa tcatagaaat gccgtctatt cctttcagca tctccttcgc tactgcaagt 2121001 cccgatttga cgcctttcgg cagatcaatt tggctaacgt cacctgtaat gatcatttta 2121061 gagccaaaac ccagtctcgt caaaaacatt ttcatttgag caggcgtggt attctgtgct 2121121 tcatcaagta taacataagc atcatcgagc gtccgtcccc tcatatatgc gagcggagca 2121181 atttcaatga tgcctctttc catcagacgt tctgtatgat ctgccccaag cacatcatgg 2121241 agagcgtcat acagcgggcg caaataagga tctacttttt cttttaggtc acctgggaga 2121301 aaaccaaggc tttcaccggc ttccacggca ggtcttgtta aaatgatttt tttgatatgt 2121361 ccgtttttta aagcatggac tgcttttacg acagccaggt acgttttccc ggttcccgcc 2121421 ggaccaatgc cgaatacaag gtcattccgc ttcatagcgg ccacgtattc ccgctgtccc 2121481 attgttttta cacggattga tttgcctttt gcgttttttg taatttcttc ttcatacatg 2121541 ctttcaaagt attcaagttc attcttcttt gccattttga tggcgtaaat cacatcacgt 2121601 tcagagatct ctatcccctt gcgaattaaa gcgaggagcg atcccagcag cctgtctgca 2121661 atctgaaacg attcatcatc gcctgaaaca taaatcgtct cgccgcgcgt aatgatattt 2121721 aaattcagat ctttctccat caatttcaaa aaagaatctt ggttcccgaa gagtgaaagc 2121781 gcctcgtccg ggtttttcag tttttgattc atcgcaagta aatgttctgt cattcttcag 2121841 tctccctgac aataggtgtg gtttgaacga tatcttctat aacttggtag agaataatca 2121901 actttacttt accattctca acagtctggt gcaaaacttt ttcacttttc acctcgccgt 2121961 tttcgcctat tttatcctct acatcctgtt tacccaattt aatgccttct tgaactgctt 2122021 cttcttttgt atattttcgc aaagcctctt cactttctct cgtttgctct ttgacatagg 2122081 atacagggag cttaaatccg agaaaatgaa gcgaatgctt ttcttgttct gtttttggat 2122141 gcttcaattc ctctttttta aacgtcatcc cccagatcgg gattgccaaa gaaccaaaag 2122201 aaagcttgtg ctttgtcctt actttgcccg tatagacgtt aaataatgtt tcaagcggga 2122261 ctgtcacttc tgatctatac caggtttctc cataaatttc tgcttttgag gcgacttcct 2122321 gctgatggtc ttcgctgccg atcagtcccg aaacaagcag ctgtcccttt tcaacatgat 2122381 cgtgtatggc ggccatgggc tgtccttttt gcacaaacat tctcgtaatg gttgctttct 2122441 ttttggcgac aatattgcgc gggctaacat atttttcttt ttcgggctca tttttctcca 2122501 caactttcat atgaatggtc gtccccttca gatcaactcc gacccaagtg atattgtcta 2122561 ttccattggt taatgatttc tgtatttttt cgggcgacat cattaaaaac tgcagacggc 2122621 cctttttgac gccgatttca ttaagatgct gcctcatttg atgttctgtt tcaggcttag 2122681 cgcctgtcac atcaattttc cacaccatat tggacagcaa aaacaaaaga atgaaaaaaa 2122741 tcgcaaaacc gatcgtaaac cctatattca gctttgattt cagcaacagg aagggaaatc 2122801 ccttccgatt gataaatcgg gctttacatt taaatttact tcttacccgc cgaaaggcat 2122861 gtacatcctg aagctgtata tataacgata cggcttcttt cttttttttg acatgaaaga 2122921 ccggaatccc ctgtcttgtg cattcattaa ggagccgctc aatccctctt cccgtcaatt 2122981 caagctggac cttacccgaa aaaaaagaca gccatttatt tttcacaaca tttccccctc 2123041 ggctttatga ctcaacatat cgaacgacat caatcgtacc ctccaaaagt atctcttccg 2123101 gaagaatcgc cttgatgaca aaatttttac cagatatgat gcactggccc tgcttcagca 2123161 tcagccgcac ttcattctca ctgaaaagca aaaggcctct gtggttttct atgtagatat 2123221 gaagtctgcc aaccattgta atcctcggca gatccatcat aacgtccggg ggaatttcca 2123281 atgctcttgt cagccaagct ttcatacgat tctttctttg ccccatacaa aaagaacccc 2123341 ctttcatctc atatgtatga tttgaaagga ggttctaaca ctttaatttt tacgggccgg 2123401 gcgcatcgta cggtgaggtt ttttcgcccg tggaggtccg aacacctctc ctagaacgat 2123461 cccctgtacg acggtgtctt tattcacctg aagcattttt tgttttgtgt atactgtttt 2123521 ttgtttggca gcagcaagat ctcgttccag ccctttcagg tttcttgctg tttccctgcg 2123581 tctttcttcc gcttcccgtc ttgcctgttc catacggtta gggataggtg caggggcatc 2123641 ttcttttgac tgcttctttt gaggagaagc agattgcacg tgttgaggtt tttttctttt 2123701 ttggctgttt tgcttttctt ctttgctctt tttgccgaaa atcgcagaaa tgattccgat 2123761 gatcgctgca ataataagcg gattggtcag taaatcttcc atcagcgttc tcccttctta 2123821 gagagattat gatttgcggt cttcatccga agggtctttc gtcagcttgc cgaatgaatc 2123881 acgcatttct gtgtcagcat cgatgttctt gatattcatg taatccatga cgccaatatt 2123941 cccttcacgc aaagcttctg ccatcgcaag cggcacttcc gcctcggctt ctactacttt 2124001 cgcgcgcatt tcttctacgc gggcacgcat ttcctgttct tgagcgacag ccatcgcacg 2124061 tcgttcttcc gcttttgcct gcgcgatgtt tttatcagcc tcggcctgat cggtttgtaa 2124121 aattgccccg atgtttttgc cgatatctac atctgcaata tcaattgaga gaatttcaaa 2124181 cgcagttcct gagtccaatc cttttccaag gactgtctga gaaatcatgt cagggttttc 2124241 aagcactttt ttatgattat cagatgaacc gattgtagaa acgattccct cacctacacg 2124301 agctacaatg gtttcttccc ctgctccccc gacgaggcgc tcgatattcg ctcttactgt 2124361 gattctcgct ttcgctttca cttcaatccc gtccattgcg acgccggcaa tgaacggtgt 2124421 ttcaatcacc ttaggattaa cgctcatttg aacagcttcc aacacgtccc ggcctgcaag 2124481 atcaatggca gcacagcgct cgaatgtgag ttcaatgtta gctcgctgag cggcgataag 2124541 cgcgttgacg actctgtcaa cattacctcc agccagatag tggctttcaa gctggtttgt 2124601 tccaacatta agtcccgctt tatgcgcttt aatcagcggg ttaacaaccc gattcggaat 2124661 gacgcggcga agcctcatcc caactagagt gaaaatgctg attttcactc cggctgccaa 2124721 agctgaaatc caaagcatta caggcacaaa tgtaaaaaat actgccaaaa caatgatcgc 2124781 tactgcgaca attgccagaa tcataagtgt tgacggatcc atataacttc tcctcgtttc 2124841 tatttaaatt tctctcacga caatgcgtga gccttctact tttatcactt ttactttttt 2124901 atctttttct gtaaacgatc cctccgatac aacgtcaagg cgttcatcat caataatcac 2124961 ggtaccggaa ggacgcagcg gtgtaaaggt tatacccact tttcccatta agtccgtgcg 2125021 cgtttgattt gaaacgtagc cgctctccgt gtttgtagaa tcatttaata tcaatttctt 2125081 aaagaatttc atacgctttc ccaacaccct tgtcagtaaa ataaaagctg taatcgaaac 2125141 agctgaggcg atcaagagag aaaccgccat gacagtgaag ctccccgcgg ctaaaaacag 2125201 gctcgcaata atcgctccca agcccagtaa tccaatgatt cctccgggaa gaaaaatctc 2125261 aagcagaatg agaatcaccc ctgctataaa gaggagaacc gtctcatacc cggcaaggcc 2125321 ggctgcaaga tgcccgtaaa agaacagcaa taacgcaatg agtccagccg ttccagggag 2125381 gccgacaccc ggggaaaaaa gctctaccgt cagacctaaa aaagcgattg tcagcagaat 2125441 agggacaatg accggattcg tcagccatct tgccgtcttt tccgcaaagc tctcctttgc 2125501 atagctgatc tgcgcctttt cgaacccaag cttctttacg agcgtggaca aattgtcagc 2125561 agtgccttct gaatagccta cctcaatcgc cttgtctgcg ttaagtgtca gcagatctcc 2125621 cttaggcgcg ccaacttcct tggcatctat atctgggtca gccattgcga gcgcatattt 2125681 tggatcgcgg ttatttttca ctgcggcatc ttccatctct gccagccaaa gtgattgagc 2125741 tttttggtca gcggcattgc cttggccatc aacaatcgcg gcggctccca tttttccgcc 2125801 aggcgccata taaatgtgat ctgcttgaag tgcaatatat gcaccagcag acaacgcgcg 2125861 tttgttgaca tatgcagtta cggggatctc gctttcggtt atcaaatcgg ccatatcaat 2125921 agcagatttg accaatcccc ccggggtatt gatatcaaga ataatatggt ctgcatgtgc 2125981 atcctttgcg tcttgtaacg aacgggacaa aaacgaggcg agaccctgtt cgacattttt 2126041 ttcaaccggg atcacataaa cagtttgttt ttctgctttt gcgttcagct gtacgcctaa 2126101 taaagaaagt aaaaatatac ccaaaagagc agcacggaat cctttgattt gaagcaaggg 2126161 cggtgtatcc ctccttcctt ttataataag tgccttctct tcatacgtaa caaatgtatc 2126221 aaaggtttca tttttttatg tataaaaaaa gacatctctc ttagaaagat gtccttttct 2126281 ttgccattta agacagttga ctgctcacaa gcttattaat taaacttccg tcagctttac 2126341 cttttacttt aggcataatt gcccccatca ctttgcccat gtccgctttt gagctcgcac 2126401 cgacctccgc gatggtttca tttacgattg tacgcagctc ttcttctgac agctgctcag 2126461 gtaaataaac ttctaaaatg tccagctctt tttgaacttt atctactaaa tctaaacgat 2126521 tagcgtttga aaattcctgg agggagtctt tacgttgctt aagttcacga gaaaggacag 2126581 tgagttcctc atcctcggtc aaactgtctt tcttaagctt aattgcttca ttttgaagtg 2126641 aagccttaac cattcgaacg acagtcagtt tgtctttctc acggtttttc atatacagct 2126701 tcatatcctg gttgagacgc tcaagaagac tcataaatcc accctctttt agaatttgcg 2126761 ttttctagca gcttcagact ttttcttgcg ctttacgcta ggtttttcat aaaattcacg 2126821 ctttcttgct tcttgcaaag tacctgtctt tgatacactg cgtttgaagc gacgaagagc 2126881 atcttcaagc gattcgtttt ttctaacgac cgtttttgac attctctttc cctccctccg 2126941 aatacaccaa tcgactacct ttaagttaca catataaaca tgtactttga cattataata 2127001 taagccatca gtcaggtcaa ctaagtgagt tcacttttcc gtcatgagtg cgactgcctg 2127061 tctatataat gaaagaaagg ggttggtgaa taggatgtta attctgatta gctttactgc 2127121 tcttatatta ttctttctcg caggcatgaa catgcttcga aagggcttaa tttcaatggc 2127181 gtactcaaaa attgaagaac gtttgctttt atttacagac catccgttaa aagcgtttct 2127241 tatcagtatt gtatttacgg ggatacttca gagcagctca gcctttatgg tcattgtcat 2127301 cggctttgta agtgcgggcg ttctttcttt taagcggacg atcccgatga ttctggggac 2127361 aaatgttggc tctactttta caactgaatt tattgctatc aaaatggata ttgtgatttg 2127421 ggttctttta ataggaggtt tattgttttt tctgactggc aggtatcctt tgaaacagct 2127481 gggaacaagc ttccttggac tgggcatcat cttcttttgc atcagcggat tcagccatct 2127541 tgccgggccg ctgacaaagc tgaaaacggg cgccgacgtt ctataccatg ttaacgattc 2127601 aaactggtcc gctttgctca tcggcatggt gttaactgcc atcattcact ccagttctgt 2127661 ctgtatcggc attttgatga gttttatgaa tgaagggatt atcggactga cacaggcgat 2127721 gagcgtcgta ctcggatcaa atatcgggac atgcattaca gctgtcatgg ctgctgtatc 2127781 cggcggatat gcggcgaaac agacagcata tgcccatgtg gtatttaacg tgctaggggt 2127841 ggctctagta ttgccttttc tgaccgcagc gaccggcttt gtagagcagt tatcacctga 2127901 tcccgcacaa aagatcgcgc atttcagcct tttatttaat gtggtgacag ctcttttatt 2127961 tcttccgctt acaaacttgt tttaccgatt gattcacctt cttatcccgg ctaaataaaa 2128021 aaatcggtac attttaatgc accgattttt taggttaaga agacaaacgc atgtgttcag 2128081 ttatttcatc ctcaaccaca cggacaaact gtccttcgtt gtaaggataa cctgctttta 2128141 ggattttgac ttttacgatt ttgccgatca tatcttccgt acctttgaaa acaaccttca 2128201 tataattgtc tgtgtaaccg acaaacatat tttcttcttc tgtttcctta aacgcttcct 2128261 cagggataat ctcaagcact tcattttcat actgagaagc gtattctttt gcaagctggt 2128321 cagaaagagc aatcaggcgg tgcacacgtt cgtttttcac gttttcatcc acttggtctt 2128381 ccattcgtgc agctggtgtt cctgtacgct tactgtaagg gaaaacatgc agctcagaga 2128441 atttatgttc tttaataaag ttataggttt ccataaattc ttcttctgtt tctccaggga 2128501 acccgacgat gacatcagaa gtaacagcta agcctggcag tgcttttttc aatttattta 2128561 aacggtctgc aaagaattcc attgtatatt tgcgtctcat ccgtttaagc actgtgtttg 2128621 atccggattg gataggaata tgcaaatgat tcactatctt atctgagcgg tctaagacct 2128681 cgatcacttc gtcagtgatt tggctggctt cgattgaaga aattctgatc cgtttcacgc 2128741 cttccacacg ggtgtctaat tcgctcaaaa gcttcgcgaa gttgtaatct ttcatatctt 2128801 cgccgtagcc gcctgtatga atacccgtaa gaacaatttc cttatatccg gcatcgacaa 2128861 gctgctgcgc ttgtttaatg acttcttcag ggtcgcggga gcggagcagg cctctcgccc 2128921 acggaatgat acagaatgtg cagaaattat tgcagccctc ctgtattttc aatgacgctc 2128981 ttgtgcggtc cgtgaaagca ggcacatcaa gctcttcata tactcttgct ttcatgatgt 2129041 tgctgacgcc attaatcggc tggcgttctt ctcggtattg gtcaatgtag ccaagcattt 2129101 tttcacggtc ctgtgttccg actacaatgt cgacaccggg gatcgccata atctcagcag 2129161 gtgaggtttg cgcgtagcag cctgtgacac agatgacacc gtcaggattt tgacgaatgg 2129221 cgcgtctgat cacttggcgg ctttttttat ctcccgtatt tgtaaccgta catgtattaa 2129281 tgacatatac atcagctgtt tgttcaaagt ctcttctttc atagcccgct tctttgaaaa 2129341 gctgccagat tgcttctgtt tcataatggt tgactttaca gccaagcgta tggaaagcaa 2129401 cagttgccat tactgatcac ctcttaataa ctctgtttga taagaaatcg cactcaacgc 2129461 gtatagcgga gcggtttctg tccttaaaat tctcggtcca aggccgcacg tcacaccgtc 2129521 ttgctctgtg agccgttcaa cctccgcttc tgttaaaccg ccttcgggac caaatacgat 2129581 caatagagat gatcctttcg gaaggctgct tacaatcgcg ctgaatgcgc ttatttcccc 2129641 ttgcttcgat gactcctcgt atgcaacgac acatttatcg aaatcctgca tcctttgaag 2129701 aagctgctga aaagaatgga catccatcac tcgcggcact tcgttacggt acgattgctc 2129761 agccgcttcc ttcgcaattt tcgtccatct ttcccgcttt ttctttgcct ttttgtcatc 2129821 cagcttgaca acagaacgcg cggcttggaa aggaataaag gcatgagctc cgagctcagt 2129881 ccccttttgg ataatccatt caagcttatc tcctttcgga aggccgctcg caatatagac 2129941 ctttatcgga agctctctgt tttcattcgt ccattctatc acaaggcagg acactttatc 2130001 tttggaaaca gattgaagtt cacattttgc ctcgaagccg tcttgagagc agcagataat 2130061 ctgatctccc tcattcattc tcatcacgtt cacaatatga tgaacttctt cgccggtaat 2130121 cgaaaaagtc ggcgcttcct ctatttgctg cttcgtgagc tcgataaaat atcgttgcat 2130181 acgctgtgac acctactaac tgttattttt tcgcaataat gctgacccaa tcttccattg 2130241 aaaggatttc tacaatggta aagccagctt gttccagtgc ttcttttact tcttgttttt 2130301 tatgaccgat gattcctgac gtaataaagt gaccgccttc ttttaacagg ctgtacgctt 2130361 gtgaagtaaa gcgaagaatg acttcagcca aaatgttggc cacaatcaca tcatgttccc 2130421 cttcaatccc gtctaacaaa ttgttttgct tcacttgagc aatatcgctg actttgttca 2130481 gcttgagatt gaggcgtgca ctttctacag ccacgggatc aagatcgtag gcatgaaccg 2130541 attcagcctc aagcattgca gccgcaatac ttaaaattcc cgaaccagtg ccgacatcaa 2130601 tcaccttatc acccttttgc acaaagcgtt caagcgcctg aatgcagagt acggttgtcg 2130661 gatgtgtccc tgtgccgaaa gccattcccg ggtccatttc aataatcagt tcatcagtat 2130721 ggaccggcgt atattcctcc cacgtcggca caattgtaaa cttttcagaa attttcacag 2130781 gatgataata ctttttccag gcagtcgccc actcttcttc atttacttca gaaatagtga 2130841 tgtggtttct gcccaaatca atattgtaaa gaaggagatt attaatcgtt tctttgatgc 2130901 cgtctacagt ttcgcccaga aaactgttaa ccggcagata tgctttgaca atgacaccct 2130961 catctgggta atcattgggg tcgagctggt agatttcccc gtacacattc tcacgttctt 2131021 taattaaatc aagcgggtcc tctatcacaa ccccacttgc accagcttca tgcaatatat 2131081 ttgagatagg ttcgaccgct tcatgtgttg tgtgaatgct taattcggac catttcaaaa 2131141 ctaccaactc ctcatccaat aattaatcgc ctttaaacgc gcgttttacc ttgtcaaaga 2131201 aactcatttc ctgttcgtca ggcaggtttc cgctgacttc ggcaaattcg cggataatgt 2131261 ctttttgttt atcagtcaga tttgtcggcg taacgacgcg gacgacgata tgctggtcac 2131321 cctgtccata gcctctgaca ttttgaacgc ctttgcctct taatctgaat ttcgttcctg 2131381 tttgtgtacc ggccggaatt ttcaatttca cttttccatg cagcgtcggc acttctacct 2131441 catctccaag agcagcctga gcaaacgtta acggcatttc acagtaaata tcatcgccgt 2131501 cacgctcgaa gaactcgtgt gcgcgtacat ggaacacgac aaataaatcc ccggcagggc 2131561 cgccgtttat tcctggttca ccctgtcccg agagacgaag ctgctgcccg tcatctacac 2131621 cggctggaat tgtcacattg attttcttgc gttttttgat ttttcctttg ccgccgcagt 2131681 ccgcacattt gtttttaatg attttgcctg taccttcaca gtggtggcag acccgtctgt 2131741 taacgacttt tccaaacggt gtattttgct ccacgtttaa ctggccggag cctccgcagt 2131801 gggagcatgt ttctggattt gttccaggtt tcgcacctga gcctttacat gtttcgcacg 2131861 tttcctcgcg gggaatttcg atggttgttt ctttaccgaa agccgcatcc tcaaacgaca 2131921 gggtcatcgt atactgtaaa tcagcaccct ggcgcggagc gtttggatct cttcgtcttg 2131981 tgcctccgcc gaatatactt gagaaaatat catcgaaacc aaaaccgccg aaatcgccgc 2132041 cgccaaaacc tccgccgccg aagccttggt tagggtcagt gtgaccaaat tgatcgtaat 2132101 gcgcacgttt ttggtcatct gacagcgttt cgtatgcttc ttttacctct ttaaattttt 2132161 catctgatcc ggcttctttg ttaatatcag gatgatattt ttttgacagc ttccgataag 2132221 cttttttaat ttcatccttt gaagcgctct tacttactcc cagcacttca tagtaatcac 2132281 gcttactcat ctcgcttcac tctcccgaat ttctcacata aattagattg tatcattttg 2132341 aattatgatt tttcaattcc ttttatcccg ggcaagaaaa aaagtcaaag ccaagagatg 2132401 cctgactttg actttctaat cattgaatca gattatgaaa tgtgttcttt tcggtcagct 2132461 ccggaagcgg ggctgacact aaaaagaact tattttttgt tttggtcgtc gtttacttct 2132521 tcgtattcag cgtcgacaac gttgtcatcc gctttgcctt cagcgtttgc tccgccttga 2132581 gcttgctgtg ctttagcagc ttcttcataa agcttcatag aaagctcttg aacgattgtt 2132641 tgaagctcat cttttttcgc tttgatctct tcaaattcgt ttttctcaat cgctgctttt 2132701 aaagcgtctt tggcatcgtt ggcttttttc acttgttctt cgtccacttt gccttcaaga 2132761 tcttttaatg ttttctcagt ttggaaaaca agctgatctg cttcgttgcg gacttcgatt 2132821 tcttcttttt tcttcgcatc agcgtcagca ttttcttccg cttcttttac catgcgttcg 2132881 atctcttcat ctgagagacc tgaagaagat ttgattgtaa tgttttgttc ttttcctgtg 2132941 cctaagtctt ttgctcttac gtttacgata ccgtttttgt caatatcgaa agaaacttcg 2133001 atttgaggca cgccgcgcgg tgctggcggg atatcagtaa gctggaagcg gccgagtgtt 2133061 ttgttgtcgg cagacattgg gcgctcacct tgaagaacat ggatatcaac agctgtttgg 2133121 ttatcagcag cagttgagaa cacttgagat ttgcttgttg ggatcgtcgt gttgcggtcg 2133181 atcagttttg taaacacacc gcccattgtt tcgataccga gagaaagcgg tgtaacgtca 2133241 agaagaacaa catcttttac gtcacctgtg ataacgccgc cctgaatcgc agcaccaagc 2133301 gctacaactt catccgggtt tacgccttta tgcgcttctt ttccagtttc ttttttgatt 2133361 gcttcttgta cggcagggat acgagttgat ccgccgacaa ggatgacttt gtcgatttcg 2133421 cttgcagaaa gtcctgcatc ttgaagcgct tgacggacag gacccattgt gcgctctact 2133481 aaatgagaag aaagctcttc gaatttagcg cgagttaatg taagttcaag gtgaagcggt 2133541 cctgcttctc cagctgtgat aaacggtaaa gaaatttgcg tagaagatac gccggaaaga 2133601 tcttttttcg ctttttcagc tgcgtctttc aaacgctgaa gcgccatttt gtcttttgac 2133661 aaatcaatgc cgttttcttt tttgaattca gacaccagat gatcgatgat aacttggtca 2133721 aaatcgtccc cacccagacg gttgtcgccg gcagttgaac gaacttcgaa tacaccgtcg 2133781 ccaagctcaa ggatggaaac gtcgaatgta ccgccgccaa ggtcgtatac taggatcgtt 2133841 tgatcttcat ctgttttatc aagtccgtat gcaagcgctg ctgcagtcgg ctcgttgatg 2133901 atacgttcta cttcaagacc tgcaatttta ccagcgtctt ttgttgcttg acgctcagca 2133961 tcgttaaagt atgcaggaac tgtgataact gcttttgata ctgtttcgcc aagatagctt 2134021 tcagcgtatg atttaaggtg ttgaaggatg atagcagaca cttcttgtgg agtgtaatcc 2134081 tttccttcaa tttcaacttt ataatcagta cccatatgac gtttgataga cataattgtg 2134141 ttagggtttg taatagattg gcgtttagcc acttccccta cttgacgttc gccgttttta 2134201 aatgcaacaa ctgatggcgt tgtgcggttt ccttcagcgt tagcaataac tttaggctcg 2134261 ccgccttcaa gcactgccac acatgagttt gttgttccta agtcgattcc gataacttta 2134321 ctcacttgaa taacctcctg ctatgtaatt attgattcac tttgaccatg gaagggcgaa 2134381 tgacgcgatc cttcagctta tagccttttt gcatttcctc aacaacaatg ttggagccgt 2134441 agttttcgtc ttcagcctgc ataacagctt ggtgcagatt aggatcaaat tcctgcccta 2134501 cagcttcgat ggcttcgacg ccttcttttt tcaaggcttc tacgagctga cggtggacca 2134561 tttccattcc ctggagcaaa cttttcgtct gttcattgtc ggcttcaacc tgaagcgctc 2134621 gttcaaaact gtcaagagcc ggcagcaaat cagtcacgat attttgagaa cggtattttt 2134681 gggacgcttc catctctaaa cggctgcgtc gtttatagtt ttcaaagtct gcttgaacac 2134741 gcaaaagttt gttttctttt tcctcaagca aaccttgcaa ttcgttaatt tggttttgaa 2134801 gaagttcgct ttcatttgtt tcttcctgct gttcatcagc ggcagcttgt tcttcaatga 2134861 tttcttgctc ttctgtttcg ttttgttcaa cggtttgttt ttcttctgac attgtgttca 2134921 cctccctcaa agtgtaagga gaaggacagg tgctgccctt cgataaaatt tgccaaaatt 2134981 cccttattca tcatacagac ttgttaatgc ttttgacaag tccgaagtca catgctgaag 2135041 caggctgaca accctggaat aattcatgcg ggtcgggccg ataatcgcaa ttgagccgat 2135101 ctgcttctgg tctacggaat aagaagccgt aatcagactg caattttcca tctcttcata 2135161 gtcgttttct tttccgattt taatcgaaat tcccgtgtgc ggggattgaa ccagctttaa 2135221 aacatcctgt tctttctcaa ttaatgaaag cagcgaccga actcgggtga tatcatggaa 2135281 ctcaggctgg ttcagcatat tgattttccc gccaaaaaac aacttttcaa cgtgatttgt 2135341 ggaatgaaag gttgaacgaa gcgcgtcgag tatattgtca tagtttttaa tgtgctgtct 2135401 taggtacatg acaacttctt taaatatgcg ctcattcagt tcatccattg gaacgccgct 2135461 taaacggtcg ttcagtatat ttaccagttt ttcaatatca gacagatcca ttttggtcgg 2135521 aaagttaatc gttttgtttt ccacatgccc cgtattggta acgagaatcg ctaccgccat 2135581 atcaggctga atcggaatga tttgaatctg tttaaggtaa ttctcactca acttcggccc 2135641 gagtacgatg gatgtgtaat tcgtcagatc ggacaaaatt tgcgctgatt tttgaactgt 2135701 cttctccagc tcgaaaattt tctctttgaa gatcgagtgg atttggtcca ggtcgctttt 2135761 cgtcaatttg acgggtgaca gcaaatggtc aacatagtac cgataccctt tttctgacgg 2135821 aacacgtcct gaggatgaat gggttttttc aataaagccc aattcctcca agtcagccat 2135881 ctcgtttctt attgttgcag agctaaatgt gatttcatct tttttcgaaa gagttcttga 2135941 tcccaccggc tgtgccgatt taataaaatc gttgattata acctgaagga tcagcagctg 2136001 acgatttgtt aacatcatca tcacctctgt tagcactctc aataagcgag tgctaattct 2136061 ataacaaaag tatcaaacca caagaaaaat gtcaattata actcacccaa aaaagcgcca 2136121 aaaacttcat tgcctaataa tttcccttga tgagtcaaat aaacggcaga ctccgaattg 2136181 tgaatcagcc ctttttcagc gaggtctttt aacacgcttg ggaaaagtcc atccagggaa 2136241 cggccgtatt tttctgcgaa tcgttttttg ctgacaccgg ctgtttttct caaacctaaa 2136301 aacatttctt cctcaatctg ttcttctgtt gtcacttcat gtgtatctct gtacggaaaa 2136361 cccttttcag ctatcaggtc aatgtaatgc ttaacaggtc cgacgttcac tgttcgtgtg 2136421 ccgccaatat atccgtgagc gccagctccg aaaccgaaat attgttcgtt gctccaatac 2136481 gttagattgt gcttagattc catgcctgcc ttagcaaagt tgctgatttc atattgatga 2136541 atgccgtgag cttccatctt gctcatcact atttcataca tttcagcttc ctgctcctgc 2136601 ggcggaagat gaagccgccc tttttgcatc aaattataaa ataccgtttt cggttctaca 2136661 ataagggagt aaacggaata atgctcagcg tccaatgata aagcagtgtt tatggaatgt 2136721 tccagatgct tgagggtttg ccccggaagc ccgaacatga gatcaagact gatattctca 2136781 aaaccgattt cccgcgctct ttcaaaagag gtgaatacat ctttttgctt gtgcactcgg 2136841 ccgatttttt ctaacagatc gtcttcgaac gtttgcacac caaagctaag gcgatttacg 2136901 cctgcttctt ttaatatttt taatttctct gcggacaaat cgtccggatt cgcttcaacc 2136961 gcaaattccg ataagtcgct tgagggcttt agcacgcggt tgatcatatc catcagcttt 2137021 ttaagctgtt cctcagacag ggaggtcggc gtgcctcctc cgataaagat tgttttgaga 2137081 tcaggctgcc cggtttttgc tattgtattt atcatttcct gttcgagtgc gtttaaatac 2137141 tcgtcgactg gctgactttg aataaaatat ttattgaaat cgcagtagtg gcaaatatgc 2137201 tcacaaaatg ggatatggat ataagctgat ttcaacggat tcaccttctt tacagaaaga 2137261 agccgcagta caagactgcg gcggcttcta ttgttttttc ggactgtcgt ccattttcag 2137321 aactgccata aatgcttctt gcggcacttc aactgagccg acctgcttca tacggcgctt 2137381 tccttctttt tgtttttcaa gaagtttccg tttacgcgag atgtcccctc cgtaacattt 2137441 agccaatacg tttttacgca ttgcttttat ggtggagcgg gccacgattt tctggccgat 2137501 tgcggcttgt accggaactt caaactgctg gcgcggaatg agttctttca gtttttcaac 2137561 gatcactttt ccccgttcat atgcgtaatc acgatgcacg ataaaggaaa gggcatcgat 2137621 tttttcacca ttcagcataa tgtccatttt cacaagcttg gacggtttgt agccgatcag 2137681 ttcataatca aaggacgcat agcctttagt gcttgatttc agctgatcaa aaaactcata 2137741 tacgatttcc gctaatggca tatcataaat gatgctgaca cggtttgcgt ctaaatactg 2137801 catatcaatg aaattgccgc gttttccttg gcaaagctcc attacagcgc cgacatagtc 2137861 attcggcacc atcatcgtcg cttttacgta tggctcctca accctttcga tcttttgagg 2137921 atccggcatg ttggacgggt tgtcgacaac gaccttttcg ccgtctgtca tatacacgtc 2137981 atagataacg cttggcgctg tcgtaatcag gtcgatgttg aactcacgct caattcgctc 2138041 ctgaatgatc tccatgtgaa gcatgcctaa aaatccgcag cggaacccga atccaagcgc 2138101 ttgcgaagtt tccgcttcat attgaaggga ggaatcattc agctcaagct tttcaagagc 2138161 ttcccttaaa tcattatact tcgctgtatc aatcggatac aaaccacagt acaccatcgg 2138221 gtttagcttg cggtatcccg gcagcgcttc ttctgcagga ttggcagcgc tcgttattgt 2138281 atcaccgaca cgtgtgtcac caacattttt gattgaggca gtcaggaagc ctacatcacc 2138341 gaccgtcagt tcatttgtcg gagttgcttt cggcgtgaac acgcccacct ctgttacttc 2138401 gaattctttg ccggttgcca tcattttgat tttttgtccc ggctttaccg ttccttcaac 2138461 gactctgata taagccacga caccgcggta ggcgtcataa agcgagtcga agatcagcgc 2138521 tttgagcggc gcctccggat ctccggtcgg agctggcacc ttttctacga tttgttctaa 2138581 aatctcctca atcccgatac cggcttttgc tgaagcaagc acggcttctg atgcgtcaag 2138641 gccgataacg tcttctacct cttggcgcac acgttcgggc tcggcgctcg gaaggtcgat 2138701 tttattgatg accggaagga tttcaagatc gttgtcaagc gctaagtaga cattggcgag 2138761 cgtctgcgct tcaatcccct gggctgcatc cacgacaaga atcgctccct cgcaggcagc 2138821 aaggcttcgg gatacttcat acgtgaagtc gacgtgtccc ggcgtatcga ttagatgaaa 2138881 gatatattct tctccgtctt ttgctttata tttaagctga acagagttta atttaatggt 2138941 tatgccccgc tcacgttcaa gatccataga atcgagcaat tgttctttca tttctcgttg 2139001 agtgattgcc gacgtttttt ctaaaatacg atccgctaag gtcgattttc cgtggtcaat 2139061 atgggcaatg atagagaaat tccgtattct cgattgcctc tctaaacgct tttctttatc 2139121 tgtcacaatc tatcactcct actattaaac gcaaaataca ctagcttaga ttatatcaat 2139181 aggattgtaa agattcaatg taaaacaaga aagagaaaag ttccctatca tatctgggtt 2139241 gcttttctct ttcacgtact tattgattca tatcccgtat ccattcatac attgactggg 2139301 cagtattggt tacggtgtcc gaaagcgctt ttccggcttt tgaaaacata ttgaatgtct 2139361 ccaccttttc cagctctttt tgtttttcta ctaaatcttt tgccgtgact gtttctccta 2139421 ggattgaggc ttctttttca ttatcttttc cgtcggtgag cgtaaacgcc cccttcagtg 2139481 aagggtcatg atagcctttc atactcagca tcccgtggtt tgcctgctgc atgccgaaca 2139541 gaacgcctaa aaacatgatc gtgacaagca gtaagcactt tccaaagtat gcaatcaaat 2139601 caaccaccta tttcttattg ttttttcgtc tccccgctcg ctgcgttgac cttttcagca 2139661 tcccagtaca tttcgctgaa tacgtccgcg gccgcgttag ccgcacgctg cagctcttcg 2139721 agattattat ccactccgcc aaactcgagc aaaagcgctc tatcggttaa atcctgattg 2139781 taaacaccat tatcgcctgg cgagcctttg gaaaagacac ctgtgctaag tccggggtat 2139841 tttttctcca tcagtttatg aagctcactc gcaattttat agttttcttc gaagtttttg 2139901 ctttttttcc cgacgacaaa ggctaccctg gcatagcttt tccctttaat cgttgcggtt 2139961 gtgtcttttt tgcgccgaga gtctctgtgg atgtcaatga tatattgcag atttttgttt 2140021 gaagcgaggg cgtctttcac gaccggcctt gattcatcat aggacctggc atagtttaag 2140081 ccttttttat tcaattttga ctgtatatcg gttttattca ctgtggctcc gattccctgg 2140141 gattcaagcg cttgtccgaa catatctcct acaagcgtga cattggcttt agaatggcgc 2140201 gccatgtcag gatcggtctc gccttttaat agagggagat atgattccgt attgtgcgtg 2140261 tgatagataa acacgacctt tttatcacct gttgtttgtt tcggcggatc tttttgcgca 2140321 ttatctgatt gcgtttgctg tttttcaatc tctgccaaat tcgcttctct ttcttcctcc 2140381 atcaccttag acggcggcgg cgattccgca ggcatattcg tataatccgt tccttgtcca 2140441 gctaacaaaa tctcggtatc aaattgtgca aatcctggca gctcccgacc gagaaagctc 2140501 cgcggatctt cgaggttaat gctcgtcgcc agctttaaag aaagacgaga aagatgaaat 2140561 gagctgtctg tttgagagag gtcagaagcg aaataatggt tttccatctg cagcaaatgt 2140621 gcaaatacgt cacccggcaa ttcttcagca atcccataaa aagagtcaga cgacggccta 2140681 agttccggcc ggagagacgt cagcacaccg gatagaacaa aaatcacgat aaggcttacg 2140741 ataaatagaa agatggcttt taccgctttc cctccattta ccgcaacaac aatctgtctg 2140801 tttctgcgtt tatttctcat tgaatccctc cagcgcttgt ctagtaatta ctctatgaac 2140861 aagctagagg aagtagaact gtttagtgat tgtaggagcc tttgttttct tgtgacactt 2140921 tttcatgaag cgctgtgttt aatccgttcg ctaaaacatt tgccatatcg tcgataaatg 2140981 aatcgacttc cttcggtgta accattaagt tgtgccctaa aggcgaaagc acctcgtgaa 2141041 tgagctgccg tttttcatct tcttgaaggg ttccgacaat acctaggaac gattggcgct 2141101 gcttttgatc gggaagatcg tcttcagtga gcactttctt tttcccaaac gtcatgcctg 2141161 ccggaacaag cgatcttgat ggcctgttat ccttcatttc tctgccaaaa tgttttaata 2141221 tgtagtccac cgtgtcgctg gcaattgtca cggcatcaac tactgtcgga acaccgatag 2141281 caatcaccgg aacaccaagc gtgtctttgc ttaaatcttt tcgtttattc cccactccag 2141341 accccgggtg aatgcctgta tccgatattt gaatggttgt gttgaccctt tccaccgccc 2141401 gcgccgccaa cgcatcaatg gcgatgacaa aatcaggctt cgattgctca atcacacctt 2141461 taataatgtc acttgtttcg attcctgtta tccccattac acccggtgca aaagcactga 2141521 caggcctgta accctcctgt acgttttccg gctgaagctt aaacaagtgc cttgttacca 2141581 acagattttc tactgccatc ggtccaagcg catcaggtgt cacgttccag ttgccgagcc 2141641 caacgatcaa acagctcgca tcttttgaga tattaaggtt ttcaagaaaa gctgagaatt 2141701 cctccgcaaa gacagcagag accttctcct gcatttccga atcattctcc ctgattccct 2141761 gtgcttcaag cgttaaatag cgcccttctt tttttcccga aagctctgcg ccttcctttg 2141821 taacatcaac tgtgcggatt ttaatgccgc cgtgatcacg ctctttttca ataaagcctt 2141881 taatttcttt tgtcggcaca gcctgctgat tggccattgc ttccttcgtt tccactgcca 2141941 aatcggtccg tatcaaatac tgattcacat ccagctcact ctttttcata caggggcctc 2142001 cttcacatta agtacctata ttgttgccat ttgctgaata aatcatgcta aaaagagaac 2142061 cttcaatgaa aaatacttta catttatatt gcaatctaaa ggtgtgtttg atagaataca 2142121 atttgttcta ttgtgaagaa gatttaacct taagacactg tgctacaggt tgtatcttag 2142181 gaggtgaaac acatgccaaa cattaaatca gcgattaaac gtacaaaaac aaacaacgaa 2142241 cgccgcgttc ataacgcgac aatcaaatct gctatgcgta ctgcaatcaa acaagttgaa 2142301 gcttctgttg ccaacaacga agctgacaaa gcgaaaactg ctcttactga agcagctaaa 2142361 cgtattgata aagcagtgaa aacaggtctt gtacacaaaa ataccgcagc tcgatacaaa 2142421 tcaagactag cgaaaaaagt gaacggactt tctgcataat ataaaaacga tcctcaataa 2142481 tggggatcgt ttttttcatt tctttttaac agctgtaaaa ggaacagttc gagcaggagc 2142541 tgcttgtcct ttttcccggt tttcatctca tagtccatga cggcaagctg ttcaataatt 2142601 aaacggagct cctcctctga aaaaagcctt gcttgatcca tcgccagctt tacccgaaat 2142661 gggtgaactt ttagattaga agcgatttgt ttttgtccgt atccctgttc cgcgaagtac 2142721 ttcgtctgca gaatcagccg gaactgattc gaaataagcg ccataatttt gatcggttct 2142781 tcattttgtt ttagcaaatc ataaaaaatt tgcagactct ctgttcgttt tcggttgacg 2142841 attttattga tcagctcaaa aatattttgt tcaaggcttc tagcaacaag catttttaca 2142901 tcatccagcg taatttcttc acgatctcca ataaacgtgc agagcttttg aatctcctga 2142961 aaaatcgatg acagatgacc gttcacaagc agaaccaaat gctccgccgc ttccgtgccg 2143021 attgttttct gctctgtttt tgcaaggttg acagtaaagt ctgtcgtttc ctttgcattt 2143081 aattccttcg cctccatcat aaacgcgtgc ttctttaacg ctttcgtcag cttttttcgc 2143141 tcatcaagct tttcatacgg agcaagcagg acaaagactg tgtaaggcgc aggtgattgt 2143201 atatatgatt caagcgcact gacgttgtgc tcaatttttt cttttttctt ttcacctgtt 2143261 aaaaaatatg gatttttcac aatgacaaga cgccgctccc ccataaacgg aaacgtttca 2143321 gcatctgcaa tcgcttgatc cagcgggtcc tcttccagat caaaaacgga cagattgaaa 2143381 tcctttgtct cctgatcaac gaccgtctgt ctgatcctgc tgacggtttc ttgcagcaga 2143441 tatgtctctt ttccgtataa acaataaacc ggatggacct ctcctttttt caggcttttc 2143501 cacacatcaa ataccattgt tgtacgactt cctctctttc atcatcccct tctatcctaa 2143561 attgagtttg caaaatagta aagaggaagc ctgactgctg cttccccatt tatattaaac 2143621 gcctgttcgc aagcccccgg gacagcttgt aaaaaggcga taatcaccag aacagaaaac 2143681 gttaccttag cttctagatt tttcaaaaca attccattat acttaagtca gtcaggaggg 2143741 ataaagttga atgattttga aaaaaacgtt caaagcaaac gaaatgatgc tgtagattca 2143801 gctgttggtt ttgttgtgtc cttcggattt ttcgccttct tgtttgtcat ggcaacggtt 2143861 attcacctag ttggttcata acagcgactg cccgggctgc tgatttctcg gcagtctttt 2143921 ttagttcgtc tctgttatat ctgatgtatc atatggagga tagacagaaa aggttccaac 2143981 tctgtttttg tatctatatt ggatcgttcc gttttgatct gttcgcagca cgcggataga 2144041 atgtctctgt aatagttgca gaactttttg atgaggatga tggtaccgat tgtttttccc 2144101 ggctgagata atggccgttt tcggctgaag ctgttggatg aattcttcac cggtagagcc 2144161 tttgctccca tggtgcccca cctttaacac atctgctttt atattcggaa acacgttcat 2144221 cacctcttgt tccccttctt tctccagatc acccgtcaag atccagctca taccgcccgt 2144281 ctccatccac agaacgagag atgaattatt tttgcttgcc ggatcaggtg cttccggtga 2144341 cagtacatgg aactgcaaat cctttatttg caacacatcg cctcgcttca cctcttcaat 2144401 tgccactccc tcttccctgg ctgcctgcag cactttctca tctttaggtt cagaaacgaa 2144461 ccctttcgga atcacgaggc gctttacttt atgatgcttc agcagaatct ccgcctctcc 2144521 gatatgatct tggtcagcgt gcgtcagaat taaagcgtca agctgcttga ttcccttagc 2144581 agttaaaaac ggaatcagca ccttttcccc cagtgaaaac ggatgctgtt tttcgcgcca 2144641 aggctctgac gagtaagaca aagtgccgcc ggtatcaatt aagacacgac cccgctgatg 2144701 cggagcacct acaaacatgc tgtcaccctg tccaatatct atcatatcca cttctccttc 2144761 ggaactaaga cacggatata taaagagcag aaacatcacc gtgcagcaaa tgcctccggt 2144821 taccatcaac tgcgacaagg agcgtttttc aatcgccata agcaatagga tgatcgtgac 2144881 tgtgaataaa aaaagcaaaa caggtgcagg atgtgcgatc ataatcgtga acacatcaac 2144941 atctgcaatg tttgtgatta acctattgat ccagcttatc aataaatcaa accagctgaa 2145001 aaacaatctc ccaaacgaag cggaaagact taatagaaga acacctgcta cagctcccgg 2145061 caaaatacag aaggtataaa atggtaccat caacatattc atcggtacgc tgatgataga 2145121 aaactgatga aaatgatata ggagaatcgg aagcgagccc agctgagcga tgagtgatac 2145181 aattgtcagc tgccccaagg aggttttaac ctgctgaaaa atagaagagg atagaattaa 2145241 agaaaaactg acggcgaacg atagctgaaa accggcttca aagagatgat aaggattgaa 2145301 gagcagaagg acgatgtacg aaaggcaaat tgcagttgca gagcggacac gccatttgac 2145361 aagacttcca gctaagtaaa cacccgacat gagagcggcg cgtagcactg aaggagcagc 2145421 gccggtcaac atcacataga gcggcagaaa taacagcaac agaattgacg ccttttctct 2145481 agttatacca aggcggatca tgatataaaa caaacctgct gtcaaaatcc ccacgtggag 2145541 tcctgatatt gccaagagat ggacaacacc aagcttttga tacgcggtaa gcacttcatc 2145601 ctccacgtaa aatctgtcac caactgtaag tgcctgtaca atccctgtcg aatcaggagg 2145661 cagaaggctg tttgtgaatg atatgatatg ttttctcaag ctgagcacct tgtacttgaa 2145721 attttcaggt tcgctgcagt tttggataga cgtgacagag tagttccaat gaatatgctg 2145781 ccgataaaga tactcgttat aatcaaatgc acccggcaca gttgcgtgat tcggttcttc 2145841 caatgtacca gtcaactcac atgacattcc tggttctatg tataacagct gttctttttc 2145901 accagcagac tgaatgcgat acgcagcagc ccatttttcc ttatcaggtg tctcaaccat 2145961 catagacata cggtcgccgt caattttggg aatagtgtca atcactgcct tgaattgata 2146021 ggttccctgc cgataggaag agacattctg agaatctgtg actgcataca gtacaaaaaa 2146081 caatataaaa gagaagaaac aaacaataat aagaaaagcg tgcctcgttt tgattaaaat 2146141 gatgaggaga aagaggatga aaagaaaaat agcggggaaa taagcggcgg cagtaattcc 2146201 agccgttgcc gaagctgccg ccataggcaa taataagcgc gaattacgca ttcatcacac 2146261 gtagctcgtg aaaagtgtat tcgcctgttc atgtatcttt ttcaattctt cctccgctaa 2146321 accggcatca gccaatttcc ctattagacc cgctacaaat gaaagctttt ctctgttttt 2146381 cagatcaacg atcatttcat cgagttcaac ctgttcaaca gttacacccg cctgttcaaa 2146441 taattcctgc gcatacggat gtgttttgta atcctcagca taataaaccg ttttgatacc 2146501 agcttgaata atagatttgc agcattgaat gcacggataa tgcgtcacat aaatctcggc 2146561 tccatcagtc ggcaccccaa acttagagca ttgaagaatc gcattcattt cagcgtgaat 2146621 ggttcttgcg caatgatcat ctatcattaa gcatccttca tctgcacaat gtacgccgcc 2146681 cgcgattgac ccattgtagc ctcctgctat catgcgtttg tctctgacta tagtagcgcc 2146741 gacagataat ctcggacatg tgctgcgcag cgccaataaa tggctttgag ccataaagta 2146801 ttgattccat gaaattcgtt ccacgttgtt ccctccaaat gttgtgttgc ctgaccttta 2146861 gtttacctat cataatgcat gaccgtcaaa tcactttact gtaatggaag actttatttt 2146921 ctcaaatgac ttttcaccta ttcctgaaac cttagtgata tcttcaattg tttggaaacg 2146981 accgttttcc tcccggtatg caataatagc ttcagctttg gatggcccca cccctgagat 2147041 gccttgtaac tcctctaagg ttgctgtatt gatattcacc agcgctccct tccctccatc 2147101 gctttggaca gaccctccgc caccttgctg cactgctgtt tcctctccct ttttcgggat 2147161 gtacaccact gtcccgtcct gcagaatctc cgccaaattt acttgcgctt cgtctgcttg 2147221 ttcactggtc ccgcccgctt tctcaattgc ctgagatact ctgtcccctg ttcgcatttc 2147281 ataaacgcca ggatgctgaa cagcaccttt gatgtctatc acaattgttt cgtttgactc 2147341 gtcgttgttt gcttcctgct ttaccactgt attttctgtc tctgttggta cagcttgctt 2147401 caccggctct ttatttttcc ctgtggccag aaagatcata atcgctgtga aaacagccgc 2147461 agaagccgct aaaataattg ctttcttatg ctgattcaac caattcatcg tgcatgttcc 2147521 ccgctttcgt catattttat tttcataaca catatggttt agaggataat agctcaaagg 2147581 aggggaaacc attgaagata ggctttatcg gcacaggaaa tatgggtacg atccttatcg 2147641 aatcatttat tgaatcaaaa gcggccgatc cctcaaacat gacaatcaca aaccgcacaa 2147701 ttgaaaaagc gttgcacata aaaaaccgct acaacagcat aaacgttacc gaaagtctcg 2147761 aaaagctcgt ttctgaaaac gagatgattt ttatttgtgt taagccgctt gatatatatc 2147821 ctttactggc aagagcgtta ccttatttaa gaaaagatca tattctcatt tcaattacaa 2147881 gccccgttca aaccgaacag ctcgaacaat atgtgccgtg tcaagtggcg cgagtgatcc 2147941 caagtattac gaacagagcg ctggcaggtg tttctctcgt cactttcggc acaagctgcg 2148001 gcgaatctgc aaaagcgaaa atcaatgagc tgatgcagca tatctctcat ccgctgcaaa 2148061 ttgaaagtga catcacgagg gttgcatcag acatcgtaag ctgcggcccc gcttttatga 2148121 gctatctgat tcagcggttt atagatgcag ctgtttcgga aacatcagtg tctaaacagg 2148181 acgcgatttt gatgtgtaag gaaatgcttg tcggaatggg aaaactgtta gaaaccgaat 2148241 tgtataccct gcctgcatta caggaaaagg tttgcgttaa aggcggtgta acaggagaag 2148301 gcattaaagc gctggaaagc ggtgtgcagg atatgtttca ccgggtattt caaaatactc 2148361 atatgaagta cgaggaggat atttccgcag tgaaaaagca gtttcatgtg tagacgagta 2148421 tgtcatacgt tcgtctgtac tgcaaaagca taaaaaagca ttttaaaaaa ccatcgtttt 2148481 aggaaacgat ggtttttgat ttctgcgcct tgaaaaagag gcgttctgat tgtgctgatg 2148541 gctcggtatc cgtaaaatca gctgtcacgc gatggagctg aaagccgcag ttcttaagca 2148601 tttcttcgta ttcttccacc gggaacgttc tttgctcgtg tgtctcatca aaacgatcat 2148661 acgcttctcc gttccacaca aaaaacgaca tatcatgaat gacagaaagc tcgtcacttc 2148721 cggcaaagct ctgccaaata tagctgatat cttcgtcctg gtcagcaaat gtgctatccg 2148781 gaaagacttc cgcaatttta aaagatgaat gaacatcaaa cagcaggatg ccttcaggct 2148841 ttaatacccg aaaaacactt ttaaaggttt cgatcacatc attttttgtt tttaaataat 2148901 ttaatgagtc acagcatatc acaacagcgt caaattgacc gtcaaagccg gtaatctctc 2148961 tcatatcctg ctgaagaaat aaaataggct ggctactcga taccttttgc tgggcgaaag 2149021 aaagcatctc ttcgctgaga tcgatgcctg taacctcgaa gcctttttcg gcaagccgga 2149081 tggagatttc ccccgtgccg catgccagat cgagaatacg gcctttttcc gggagagatg 2149141 cttcaatcca ttttgtccat tgatcgtaag gcgcgtgtga cattagctcg tcatacacgc 2149201 ttgcaaagcc ttgataaatc attgattcat tccaaagtca agatctgcga gcggagcgtc 2149261 tccccacagc ttttcaaggt tgtagtagct tctttcatcc ttgtggaaga catggacaac 2149321 tacatcgcct agatcaacga gaacccatct tgcttcatca aagccttcca tctttttgac 2149381 ttgaatgccg ttttcatcag cttgatcctt gatttcacgg gcaatcgcct gtacctgttt 2149441 atctgaattt ccgtggcaga tcagaaaata atcagcaacc agagaaatac cttccatatc 2149501 cagtgctaaa atatcctctg cccgtttatc atcgcaagcc gcagctgcga tctttaaaat 2149561 ggacttttgg ttcattcaca aattcctcct gttcagctgc cagacacaag ccagttatac 2149621 gttaaaaatg tgtctggaaa aaccggttga ttttttttca taagaaaaac cattgtattt 2149681 ttaatggact gaatcagcgc ttgattcaaa tctgtctcag caagcttacg cacctcatcg 2149741 acaccgggaa atgcccggtt tggctcaatg taatcggcaa cgtaaatgac tttttctaaa 2149801 agtgtcatgc cggggcggcc tgaggtatga tacctaatgg cgtcaagaat gtcttcatct 2149861 tgaacccctg cctctctttg gaccaaataa gcgccgaccg gagcgtgcca gagctccgga 2149921 ttatgatcca ataaatgcgc aggcattttt tcacgcgcaa taatttgttt catttcttct 2149981 ttcgggcgga atttggcgta atcatgaaag attgccgcta tttccgcttt tttagaatcg 2150041 gctccaaaac gctccgcaag ttcgatcgcc gtgttcatca cgccaaccgt atggatatat 2150101 cggtgttcgg tcaattgctg cttcacgcat gcaagtgcct cctcacgatt catataaacc 2150161 attctcctct acatacttct tcactttatc agggattaag tagtcagtgg gcttcttgct 2150221 tttaaaccgt tcccttatca tagttgatga tacctcaaat tccggaacgt ctgcaaagag 2150281 aagcggataa ggggtttcaa catgaaaacc ggggcgcttt actccaataa attgaatgag 2150341 gttcagcagc tcgtccagct tataccattt cggcaaatat tcaatcatat cagcgccgat 2150401 aataaagaac agctgatcat ttggataacg ctgcttcagt aaagaaacgg tatcaaaggt 2150461 atatgatggc ccttctcttt ccatttcaac aagctccagc ttaaaggacg gattagattg 2150521 aattgcaagc tttagcattt ccacgcgatg aaagctgtcg gtatagtctt cgttctgttt 2150581 atgcggcgga atttgattag gcataaacca aatttcatca agccccgcct ggtacagcac 2150641 ctcattcgcc attaagaggt gaccattatg cggagggtca aacgtgcctc cgaaaattcc 2150701 gattttcttc atttcaacca cctttaagga agctcgattt gtttattttc ctttgattcc 2150761 ttatataaca caatcgtatt gccgattgtc tgcaccaatt gagagcggct tccttttaca 2150821 agagcttccg ctacatcgtt tttatcctct tcgcaattct gaagcacgct gactttaatc 2150881 agctctctcg cttcaagcgc ctcagcaatt tgtttaatca tgttgtcgtt tactccgcct 2150941 ttacctactt gaaaaatcgg cgttaaatga tgcgcttttg aacgcaaaaa acgtttttgt 2151001 ttacctgtta acattctgtt cctcctaatt ttcctattac aatagatctc attttttcaa 2151061 tattaggctc ttgtccagtc cacaattgga aagacaatgc tgcctgttca acaaacatgc 2151121 ccacaccatc gagtgttttc aagccttttt ggcttgcttc ttttaaaagt gccgtctgta 2151181 ttggattata cacgatatca catacgacgg cactgctcgc ggcacgctgt aatgaaagcg 2151241 gcacatcgtc cacgttcgga tacatgccca cagacgttgt atggatgata acatcatact 2151301 gctcaagacg ttcttctgct tcttttatgc ttaatacttc tttattgtga aacgagggag 2151361 tagcttctgt aagccgcttt gctttttcta acgtccggtt gcaaatgtca aattttttcg 2151421 gggtatttcg gacaattgtt gtaaaaatgg ctctcgccgc tccgccagcg ccgatcatta 2151481 agaatgacag ttcagagatg ggcttgtcta ataccttcat taatgacttc acgaagcctt 2151541 ccccatcggt attgtatccg acaagcttat ctccctctct tctgaccgtg tttacggcac 2151601 cgagcacttt tgcactctca tcaatatgat ccaaataatc cataatggaa accttgtgcg 2151661 gaacagtcac attgattcct tgtacgccta gagctcttat tccttttacc gcatcctcca 2151721 gatcattctc ttctaccttg aaggcatgat aatgtccgtc aagcccgagg tctttcaatg 2151781 atgcgttatg aatatcaggt gacatagaat ggccaatagg atttccgata accccgtaca 2151841 gctttttcat acacctctcc ccttttctta aattaatgaa cgccgaacaa atacatgaac 2151901 gccttttggc gcgtatgcag ttaccttttt atcagcgtca tggacagtaa cccagcctaa 2151961 cccagagaaa acgatatctg tctttttgtc ttttatcgta aacgtatggg cgaccaattc 2152021 aggaaactca tccatttcat ctttacccgg aggtgtgagc aattcccctg catgcttttc 2152081 ataaagcgcg tctgcatttt caagttttgt tctatgaatc atcagctcat tcggcatata 2152141 gcaaataaaa ggagatcttt ccccagacac ataatcaaac cttgcaagtc cgccaaaata 2152201 cagtgtttgc tgatcattaa gctggaatgt gcgaggcttc agctcctttt taggagataa 2152261 tattttcagg tcctttttat tgacataatg cgccatttga tggttgttga taattcccgg 2152321 tgtatcataa agcgatgaac cgtcatccag cgggatttca atcgcatcaa gggttgtgcc 2152381 aggaaattgg gatgttgtaa taatatcttc ttcacctgac acttctttaa taatccggtt 2152441 aataaaggtt gactttccta catttgtaca tccgacaaca tagacgtctt ttccgttgcg 2152501 gtaatgctca atcgcgtcaa ttacttctct gattccctgg ccgcgacccg cactgaccaa 2152561 aaatacgtca accggtttta agccaagctc tttcgcttca cgcttcatcc attggatcag 2152621 acgctctctt ttcagtgact taggcaaaat atccgcttta ttgccaacta ataagatagg 2152681 gtttcccccc accaagcgct gcagcccatt aatccagctg ccgttaaaat caaaaatatc 2152741 aacaattttt acgaccagag agtccgtttc tccaataccg tgaagaatgt tcaaaaaatc 2152801 atcatcagtt aaggagacat cttgtatttc attatagttt ttcagtctga agcaacgctg 2152861 gcaaatcaca ttttctttcg taagcgatgc aggcggcgcg taccccaaac ctgttttgtc 2152921 ctcggtttgg atcgtaactc cgcacccgat acaaacaacc ttttccattt cttactcctc 2152981 ccactgaatg tgcccttttc gtttgagagc actcagtatt ctgcgttcga cctggcggtt 2153041 aaagcgcgta atgaatccgt cagaggaagc gactggcacg accaaaatcg tatggtagcc 2153101 gtttcggttt cccccgagta catcggtcag cagctggtct ccgatgacaa cgcagtcctc 2153161 ttttttcagc tccatattgc gcaccgctct attaaaggct ttacccatcg gttttcttgc 2153221 tttatagatg aatgggattc caagcggttc tgagaaaagt ttcactcttc tttcgttatt 2153281 attagagaca attgtcactt taatgccgtg ttccttcatt tcttcaaacc actcgatcaa 2153341 tcgcggcgtc gcgttcggcc tgtcccattc aacaagcgta ttatccaggt cagtaataat 2153401 tccttttaca tttcgttcct ttaatttctc aggtgtaata tgaaaaatat tttttacaaa 2153461 ctcgtcaggt aaaaaaaact tttttaacaa aacccgcacc cttccctttt tctttctttc 2153521 aaaatgattg tcgaaaaaaa tcgaacttgc gcctaaagaa aaactgagca aaaaaatttc 2153581 gacaaaaatt gggtttcttc accaggtgtg gataaattta cacacactat ccactcttat 2153641 tacatcactc tttagacaaa ttataaacac gatactcaca agttatccac tttttggtgt 2153701 ggataacaga acgattgttc ttatatgcat ttcatggtag attaaagata acttcaacct 2153761 cagatgaatg caacttatca ttgtatgcgt taaaatcatg aatgattcca acttttaagg 2153821 aggtgcctct cccattaatt gggttcctag catgagaaaa ctgtctgatg aattactaat 2153881 agaatcttat ttcaaagcca ccgaaatgaa tttaaaccgt gactttattg agttaattga 2153941 aaacgaaata aaaagaagat cgctcggaca tattatttcc gtatcttctt aataggaatt 2154001 tgtctatttt ttccgggcgt atttcctttt tttactcaga tgactgatat tatatcactt 2154061 tggctgcgcg ctttactact attttcagca aaaaacaccc ctaaaaagag gtgttttaaa 2154121 gggccggtta ttatgctaac cagtatatgc cgcccacaac aaggagaaca acaactaaaa 2154181 caacaataaa agcgtatcca tatgctctgc ctgcgccata catgtgaagc gcctccttaa 2154241 taaggtttta taacagccta tgtaggagaa ataaatcgga ctaggcggtt gtccggctca 2154301 acgctgcagg atctgccccg cgaactaatt tattaatgtt caacaacaga atttcgtcta 2154361 ttggcaataa agaatccaca aatcattgca agaatggcca tcgcccacca gaacgttgag 2154421 atcgcctgat catgatcgat gataatcaaa cgaatgacag ctgtgatgcc aatataaatg 2154481 aagtagcgaa gcggaaaatg aaagtctgat ttgaagtatt tgataatcaa agcaatgaac 2154541 tcaaagtaca tgaagaatat aagcagttct ccaagcatct cataatagct gtccactttg 2154601 ttgaacagtg acttgtatac gaatagcaca atgtaccaag tctcgctgat cagaagtgcg 2154661 cttaaggcta acgccagaaa gaacagacag acgttgagaa gcgcttgtaa caggtaaggc 2154721 acctttttga atttgttaga aaatctcatc atgttgtctc ctatttcaat atattcgtgg 2154781 tttttattct cagcctacat cttggtgttc caaaatcgta gcacaatgta gtacttagaa 2154841 ttcttttgta tactgtgaaa ctgtccctgc atgcgggaca tcattcgcgc aatgcttctt 2154901 tcaccgagtc cgttgctttc cggtgttata tctgcaagtt taatcgtatt gctaacatgg 2154961 atctcaaata tctcttgatc cgatacaaac gtgatactga ttttttcttc cggatctgcg 2155021 tatttcaata agtttgacat cacattatca aatacacgac caagctcctc caaattcacg 2155081 ttaatatagg tttccggcag ctcgcctgaa atatggaccc gaaaatgctc ctgatgaagg 2155141 atagcaatct gatctgatat tagatcgtag atcacttctt tcactgcaac ggtctccaga 2155201 tcggcctcat attccttgtt cagcaggaaa tacgcaaaca gattgtcaga caagcttttt 2155261 aattgcagtg ctttaccata agcattggct acataccgat ctttgctggc acccgcttcg 2155321 cctccctctt ttttggcaaa ctccagattc atgatcagcg acgtcagcgg tgtgcgcata 2155381 tcgtgcgaca tttcggtaac caggctgcgg ctctcagctt gcaattcctc gatagcttta 2155441 agtttatcca ggaaagcttt ccgcagatcc tcaatgctct ttgcaatcat cgctaattca 2155501 tcatgccctt ttatcgtcat ctcgtagtcc agttcgcccc cttcaagaat atgaatctct 2155561 tgatgaatcg ttttaaggta gcgaagactt tggcgaattc cgaagagaac aatgattaaa 2155621 aagatgaggg ttgccccgag caaatccaat gcaaaggcca gatcataata tcgggaagag 2155681 tagaaaccgt cgataatgac tcgtccttca ccatcgctaa acttgacagg atgtgaatga 2155741 ttttgagcgt actgagtcag cttttccttt ccataatccg attcggaata aatagaatca 2155801 tattgcagct cctgatcctt gaatatggtg aggttaatgt aattttcttt tttgacccac 2155861 tcgccaaacg cttttctatc tgatgtagac aactcatttt ctgaaacgta cttgctgaat 2155921 ttttgaatgt atcttgctga ctcctcgtga taatactctt ccgaactcag atatccctcg 2155981 atcagatcat ctgtgatctt ttgcaacgtc agaaagatca caccactcac aatcgcagca 2156041 accattatca gcaaagccag ttttttggtt agcgtaaatt taagatgcgc caaatcgata 2156101 tcctcttccc cattcagttt ttatataaac cggacgtgcc ggatcatcct caattttgga 2156161 gcgcagcttc cgtatatgca ccatcaccgt attgttggaa cagtaaaagt aaggctgtcc 2156221 ccacacactc tcatatatat tttgggcaga aaatattttg ttgcgtttgt tcatcagaag 2156281 tttcaggata cgatactcca gatctgacaa cttgatttgc ttctcctctt tccacacctc 2156341 attaaattct tcgctcactc ttagtttgcc cccgataaga aatgtttctt cctgttcctt 2156401 cttttcctga tagatagtat atctgcgtaa ttgagcaatc actctagcgt gaagttcctc 2156461 ttccgagaat ggtttagtca tataatcatc gccgccggcg agtaatccct cagttttatc 2156521 gagtgtactc gatctggccg tcagaaacag aatcgggacg ttagaggatt tcctgatgtg 2156581 ctgacatgtt tcaattcccg aaatgcctgg catcataata tccaaaataa ccaaatcaag 2156641 cgagtcattc acaagttgca atgctcgctt tccatccttg gctcttagca cctcgtaacc 2156701 tgcacgtgta agggattcct ccaaaagatc accaatatcc tcatcatcct ctacgactaa 2156761 tattcgatag gccatgtctc tctcacctca tgattcttgt tgttatttct cgtgtgtcct 2156821 tactatatat cgttcatagt aataagtacg ttataagata ctacgtaaat cttaacaatt 2156881 tatgaaagct gatgctcgcc acaaatttgt cacattttct aaaaaaaatg atgactcttc 2156941 ataaattgtt aagattcggt ctttatattt atccattgta aggctcaagt ttttcagatc 2157001 cgcactacac attgccgtga taaatgggaa aggagtattg atatgattgt acaaaaagaa 2157061 ggacgcgggc aaccggtgag tctgcgggaa cgggttcatt ttctggacat cgtacgagga 2157121 tttgccttgc ttggcattat tattgtcaat tattttctga tcgtagattc agtaaaggga 2157181 ttcgaaatgg cctccgatga cgtactgcat aagctggttt cctggtttgc cgaagggaaa 2157241 ttcgttacgt tattctcctt cctgttcgga gtcgggttta tgatctttat ggatcgagcc 2157301 gcgcagaagg tagagagtcc caacaagctg tttgcccgca ggttatctat cctgttggga 2157361 tttggcattt tgcacatcac atttgtttgg gtcggtgaca tattggcctt ttacgccgta 2157421 agtggcttcc tgttactcgc cttctataaa cgcacggcca aaacggtgct tagatggatt 2157481 atcgcactta tcgtgtttca attcctgact cctgttttca caatgttgta caatgtcatc 2157541 aatactgcag ggtcaaaaaa cccgaatttt tcagagttta ctttgtttag ccacagcagc 2157601 cttacctaca tggaatccat cagcactcgg tggacagata tggtcacgat ggctgccggc 2157661 tctttctcta tgatctattc catgtttctc atgtttctgc tgggcgtgta ctttgttaag 2157721 atggaatttt tcaaagacat ggaagcgaaa aagcctatat ggaagcgtat ctggatcatt 2157781 agcacaatcg cttttctaat aacacaaagc agtatattac tagacatgtt taatctttct 2157841 gagaatatgc tgtggaagga catttcctct gtcttgggtc aaaatggcgg cttaaccgga 2157901 agtatgtttt atatgagcac ttttgcaatg ctgtttctat accttcctca gctgcgaggc 2157961 cctatgatga tattcaccaa agtcggacgg atgtcattga cctgttatct gcttcactct 2158021 atcattggaa cagttctgtt cctcaggtac ggattcgggc ttgcggatca tattcaatcc 2158081 gccggcacgt tcatgttcag tctggccgtg tacttcgttc ttatgagctt tagtacattg 2158141 tggttgaaac ggtttaggta cggtccgatg gaattagtat ggcgcaagct gacgtacggc 2158201 aaagtaaacg ggagtcccaa agcaactccg ctgcattcgg aaaaatctat tcagaaataa 2158261 cccccttgca cagattgcat gacttcaaat tagtgttgtt gaatgaagcg ggcattaaac 2158321 ggacagattt gatatatgga ctagttattt ttatatcatt taggcttctt tgggctaata 2158381 aatccaccag agtttactca atgtgcattg ctcatgatcg aatctaaatt gaatctttta 2158441 cgcatgttca tagtcaaagg cgcctcattc gactattttt gtaacttttc gcaggaaaaa 2158501 ttcgagaatg atgacaaatc ccgcatacga cacttaatac ggtagtgaac aatagtaaat 2158561 tagggttaca tgcagcttgt tttccaatga aacaaagaaa aagaatcata caaaaagaca 2158621 ggagaaagct tttgaagtat tttaacgcca aatttaccgc ggaagaaaga gcgatggaat 2158681 cacttttttg tgaaaaggcc tcgcagagca gctcgaatgt tttactgaac gactgaactc 2158741 tatattttag caactgaggg agtgaacaat catgaaaact aaaaatgaac caaaagttat 2158801 tctggaacta gcaaaggaat ctgatctgcc agaattccaa aaaaaattac aagaagcctt 2158861 tgcgatcgcc gtgattgaaa cgttcggtga ttgcgaagat gggccgattc catcggacaa 2158921 tgatgttcag gagtctttca atgctcccgg agcagtggta tatcatattc ttcaggatgg 2158981 taagaatgtc ggtggtgcag tagtacgtat caacagccaa acaaatcata attcgctaga 2159041 tttattctat gtatctccag aatatcacag ccaagggatt ggtctttctg cttggaaagc 2159101 cattgaagca cagtatccgg atactgtgct ttgggaaacc gtgacacctt atttcgaaaa 2159161 gcgaaatatc aacttctatg tgaataagtg tggatttcat atcgtagagt tctacaatga 2159221 acatcactct aatccgcata tgcatcgcaa tggacgtgaa gatgacaagc ccctactgaa 2159281 tgatgatgac tttttcagat ttgtaaagat tatgaaaaaa aaggactaaa caattgaaca 2159341 cggcgagatg ccgcagagag ttgctggtaa cttttttata tttcattatc agaggaaggt 2159401 aataatgatg tttaaaaggt gttttgatcc ctgtctcata aacaggggtc aaaacacctt 2159461 tgaatcatcg gtttcttttc tgacatatac cacgcccact agtccctcaa catagtaaaa 2159521 acatatcatg agttacaaaa gcttttattc aaagcatatg tttattttat ttatacttat 2159581 tttcatcatt tttcagaatt ctggacacaa atcgggtacc tattagaggc caaggaactc 2159641 tacatttcat taagaaatac gtactcattg ccctgcttta attaatttta agccctcgca 2159701 ctatgccccc ccctgaatta agtatttgat gtaactttga aattaagttt atgaaaatct 2159761 gtcacaaacc cttatttcat aacacatcat ttgtttcagc ttccctcgcg aataccggat 2159821 taatgctcgg ctttaagata gtcaaccaat ctctccgcac tgttcttaac atcttctttt 2159881 gaaagatgaa gtgtcccata ttgtgtaaac gcaggaagaa aacgcattcc tatatagtta 2159941 gcagtgactt gaaacggtct gataagctcg ctgatcgtga tattatattc tccgcctgct 2160001 tgataatcag attcctgtgc gcctaaggag atagctaaga gtagttcttt tccatgcaat 2160061 ttagttcctc cagttccata agcccagcca tgtgttaaca catcatcttc ccattgtttg 2160121 agtaacgcgg gactgctgta ccaatacatt gggaactgaa aaacgatacg ctcatgatct 2160181 aacaggagct gctgctcttt ttctacatca atgataaaat tagggtattc accgtacagg 2160241 tcatgaaccg taatgtcttt ctcttgcttt aaacgattca tccaggtttt gttgacaaca 2160301 gacgtttcca aattaggatg tataacgata actaatgttt tcattagact gattatcctt 2160361 tctttgccaa ttagttatta ttttttacga taatgaattg attctaattt taaaatagca 2160421 actttattta cacctatttt atcctttttc atgaattcag ggcaactaat tgggcaccaa 2160481 aatcaatgat gacttaagac attgttttgt agaaatccga tatacagaat aatccattat 2160541 ttagaaaatt tctacctttt ccctcaatcc gagctcgctc ttcatgcgga tggcctattt 2160601 taaaggaata actgactatg ttcatcagtt attcctttaa aatacgaaag tctacgatat 2160661 ttccatatcg atccgcttca atgtgacagc acccctcaag cagctgtttt aattttccac 2160721 gtccgcgttg tacccttgat tttgctccgg agtaagaaat gccgagcttt tcactcaact 2160781 ctttttgtga taacccctgg aaatcagtta actcgagcgc ctctcgatac ttttcaggca 2160841 accgtttgat ggtcgatcga atacacacag ttgcttcctt ggtgaaattt tcttcctctg 2160901 cactgtcatt aaaatgtaga acatcaggca atatttcgct tgtttttttt gtacggtaaa 2160961 aatcaataat cgtatttcta gtgatccgat aaatccagct gtcgatcttt tgttcatcga 2161021 tcagatttgg gagatgcact tgtattttca taaatacgat ttgcaagagg tcatcaacga 2161081 tagattgatc gttaacccta tgtgaaatat atgtttttaa cggctgatga aattgatccc 2161141 atagatcctc tatattcatt tgaaaaaacc tcctataatt ttgcgtctgc tttacatttg 2161201 cttcgtcttt ttaatcgtaa caaagagcaa acaattgttg aatcaattgt attgcagctg 2161261 ttgccaaaaa taatgataaa ggagaggttt gttgtggagt atacctattt agggagaaca 2161321 ggattgcggg tgagccgttt atgtttaggc acgatgaatt ttggagttga tacagacgaa 2161381 aagactgcgt tccgtatcat ggatgaagca cttgataacg gcattcaatt ttttgatact 2161441 gccaatattt acggctgggg caaaaacgca ggattgacag agagcatcat tggaaaatgg 2161501 tttgcacaag gaggacagcg ccgcgagaaa gttgttctgg cgacaaaagt atatgaaccg 2161561 atttctgatc cgaatgacgg accaaatgat atgaggggct tgtctctata caaaatcaga 2161621 cgtcatctgg aaggatcact gaagcggctt cagacagatc atatcgaatt gtaccaaatg 2161681 catcatatcg ataggcggac accgtgggat gagatatggg aagcttttga gactcaggtt 2161741 cgctccggca aagtagacta tattggatcc agtaattttg caggctggca tttagttaaa 2161801 gcgcaagctg aagctgaaaa acggcgattc atgggactcg tcactgaaca gcataagtat 2161861 agtttattag aacgaacagc tgaaatggaa gtgctgccgg ctgcacggga tcttggttta 2161921 ggagtagtgg cgtggagtcc ccttgcagga gggcttcttg gcgggaaggc attgaaaagc 2161981 aatgccggaa ctcgtacagc aaaaagagca gatttaattg aaaaacatcg tttgcaactc 2162041 gagaaatttt cagatttatg caaagaacta ggagaaaaag aagcaaatgt ggctttggca 2162101 tgggtgctgg caaatccagt tttaactgcg ccgatcatcg gaccacgaac ggttgagcag 2162161 ctgcgtgata cgataaaagc cgttgaaatc agtctggata aggagattct ccgcatgtta 2162221 aatgatatct ttcccggacc tggaggagag acacctgagg catacgcctg gtgatacatt 2162281 cattactcaa tactgacatt tttcttaaat atttatactg aactatcata ttaagaaaga 2162341 caagagcatg tttgtctctt gtcttttcca catcgtgctg aaaatgctgg ctaaacatcg 2162401 acaaaaatgc tgccgcttaa aaaagaaccc taaacaatag agtaactgga aagacaactg 2162461 gcttgatcag cttgggaccc ctttcagctg tatttaaatc aatcaaacta atgattcatt 2162521 ggcagtctaa atattattat tgtttcttta caaaatagta atagcccctg taatgattgc 2162581 taacaacgta ataactaatg atgtaattac agcccactta acggcaaacc tttgaaatga 2162641 ccccaagtcc attttaagca tgcttactag caatactgtt gacgcaacca atggactcat 2162701 cagatgaacc ggctgcccca ttatagaagc ccttgcaatt tctactggtt ctataccata 2162761 tgctgaggca gcttctgcaa agataggtac cataccaaag taatatgcat catttgataa 2162821 aacaaaagta aacggaatac tagtgagtgc tacaataacg gggaaaaacc ctcccattga 2162881 tgaggggatg atggatatta atgatcctgc tatggcatcc accatctttg tcccggataa 2162941 tataccagca aatactcctg ctgaaaatac caataatacc acggttatgg cattaccaga 2163001 atgctcggcg attcgctcct tctgcatttt tacattcgga taatttatag taagggcaag 2163061 aacaaaacca attaaaaata aaactgacgg atgcttagtt ccaagcacaa taaacaccat 2163121 gatacttata acgaggaata aattaagata tattaagcgt ggccttttca attgttcgct 2163181 ctccaaagta gcagccatat aagattgaga gctgtccttt gttatatgtc taggctctaa 2163241 ttgaacgatg cctattcgat tcctctcttt ccttcccatt agaaaagcca gaaatatcac 2163301 acaagcaata cctccaagca tggtcggaag taatggcaca aagaaatctg aaggatccaa 2163361 acccagcact gaaatcgctc ttgtagctgg tccgccccat ggagtcattc cgctaacgat 2163421 actcaacgac agcattgcta atgtcgccat aaccatggga ttcataccaa ttcttttata 2163481 caaaggtaac attgctgaga ctgttatcat ataggttgtt gtaccgtccc catctaaagc 2163541 gataagcatt gccaagacgg cagaccctat cgctattttc acagggtctc cctttactat 2163601 agataaaatt ttttctatta gcggatcaaa taaacctgca tcaattaaaa ttccgaaaaa 2163661 aagaatagca aacaatagca atgccgctga acttgcaact gtttgaattc cttctaaaat 2163721 catgtcgcca atacccttac caaaacctcc aataagagca aaaacaatgg gagtgatggt 2163781 caaggcaaca ataggcgaga ctttctttgt cattattaat attgtaaaaa cagttaccat 2163841 cgaaaaacct aaaatagtaa gcatattaca cctccaagaa tgcgctttca aatgactttt 2163901 gattaacata tcttatacgg tgtaataagt taaataaata tttttttact gtgtttcaaa 2163961 aaaaattcta tcataacttt aaatggttac catttgttca ccctttaaaa aatcaatgaa 2164021 tgctttaacg agtttgattc ctaatgattt ttgatcgtac attagccaag tatctctcat 2164081 tagaggctta cccttagcat tatacagttc cattgtgtac aaatgatcag attcctgcag 2164141 gcaaatttct ggtgctatgg agtaaccaag accatgcttt accatctctt tgcaagtctc 2164201 ttgtcgatcc acttccattg caataatggg ggcttgtttt agattcgtat gcatccaatc 2164261 ttctataatc gtttttaaag aagcatccgt tttatatttg ataaaaggta aaaaaggaag 2164321 ttgctctatc gttattggtt tttttgagat gatatgtaat ttttcccgtg tcagccgttc 2164381 ctccacccct ttccagcgat ggcttcctct cagtataccg acttgtacaa taccagcatc 2164441 taataatttc atgacatctg tgctccagcc tgtttgtaca ctatattgga cattaggata 2164501 catagtggaa aattccctta ataacttagg gagcttatat tgagcgaaat tgcttgatac 2164561 ccccagcctt agatgtcctt gcacctcttt gcttagatta gagatatgat ctttggtatc 2164621 ttgaagttcc tgtagcattc ttcttgcata agcaaccaag tgttctcctt ccgcagtaaa 2164681 ggtaattcct ttatgccttt tggtgaataa ttcaattccg aaaatctcct caatcttttt 2164741 caaccgataa gtgatggaag gctgtgatgt aaataatcgt tctgctgttt ttgttacact 2164801 ttgttcttcg tgaagaattt tcaataaaat ccaatctttc tcatccattt tcatcttcct 2164861 ttctagtcct tctttcacaa ttataaaagt ttttttatcg aatattaaga aaacttatat 2164921 tttattttta tttttttacc ttctacacta aaaaacataa aaaatactac ctttaagatg 2164981 aggatgatga cgatggtcaa gacgaatgta acaatcatga gaggcggaac aagcaaaggc 2165041 gtttttttcc acgaatcagc catgcctaac aataaaaacg aatgggagcc ctttttgctt 2165101 gatgtcatgg gaagtcctga taaaagacaa atagatggtt tgggtggcgg taattccctt 2165161 actagtaaag tggcaataat aaagaaagca tatacttcgg atattgatgt tcactatact 2165221 ttcggtcaag tcagcatttc ggaagaaaag gtggacttta aggggaactg cggaaatatc 2165281 tccgctgctg ttggtccatt tgctattgaa gaaggacttg taaaagcgaa agaaccaatg 2165341 actgcggtaa ggatcctgaa taccaatacg aataaaatga tcattgcgga agtagaagtg 2165401 gaagacggtc aggtcaaata tgacggagat gttacgatat ctggagtacc tggatctgga 2165461 tctccaatct atttaaactt tcatgatgcc gctggttcag ttaccggtca tttattgcct 2165521 actggaaata gttcggagtt tttagataca agtcaaggcc aaatagaggt gtctattatc 2165581 gactatgcaa atccattagt ttttgtggaa gcgagcagta tcggcctgga tggaacggaa 2165641 cttgcagaag aatttactga tctacagttg gctcaatttg aagaattaag atccattgcg 2165701 gcagagaaat gcggctttgc cagtcgattt tcagctacaa agttatcgcc ggctgtcccc 2165761 aaactggcta tagtagcaaa accagagaaa tataaagata gtacaggtgc ttggcattca 2165821 agcgttgaga tggacttaca catcaggatg atgtccatgc aaaagccaca tcaagcactg 2165881 gctgtcactg gagcgatatg tacaacaaga gccctttcag tggaaggtgc aatccctgca 2165941 agaatagcaa aaaaccactc tacaaaggtt cggctagctc attcttctgg tattattgaa 2166001 acaatggtgg agcccactgg tataaagatc gtccgtaccg cacgacgtat tatggacgga 2166061 acagtttata cgcatggaga ctatcaaatg atgtagatgg actgtgcaaa aagcctcccc 2166121 cctttccatc gttaatagat ggattgaatg cgccttcttg cacagatcca ttgtaatctt 2166181 gcatggcttt aaaaaagcct ctatattgtt ttttatgaaa tcgccaaggt cctttcatgt 2166241 atctgcctca agcatgacat aatcattata gagaaaattg aatacttttt actgcaaata 2166301 aaaagatacc aacatcattg gtatctttta gattgagttc atctgcagcg gtttcttttc 2166361 ctcactgctt atttgattac aaaattaccg tactcgtttg aacgaacatg aatcggtccg 2166421 tttagattat agttgttctc cttggcgata gagcgaagca cgtccacacg ggcaactgat 2166481 tctctccatt cgtcacgggt gtcatgattg gccggattca tcagatcgtc atagcgtacg 2166541 tccaagaatt tattcaacca cttcttctcg tctattccgt ctttaggtga tccgcccgct 2166601 tttttgttcg tacgtttaat caaggcataa aaagagtcag ggtcatcacc atcgccatgc 2166661 tgaataaccg tatcgtacat cacagctctt gccaatgctg tttttagtcc ggcattatcc 2166721 gatcgtttca tggcaggctg ataatacaaa tggtcattta ctttgtcttg agcggcgcga 2166781 aattccttat catttgcaag cgacttccag gcagaagcga atcccttgag attgcttgta 2166841 tcatcgcttt cttccttggc cagacggcgc aattcaggca gatacttttt cagtttgtta 2166901 ttcggaactg cctttgtgta tacttccact acttccaatg catccccggt agccgttgta 2166961 aagcctgccc gtccgcatgt atagcctcgc ccgtcatcca atcgctctac atatccatat 2167021 tggatctccg ttgtgccgtt ttcaaagata cttgtcagct gttccgcccg gcgcttttga 2167081 tctttattca gtcccgccgc aaaaaccgtt tcgctcatca tcagggtaaa aaacatggtg 2167141 aaaacaagta atgagatcgc tgcttttttc caaaaatctg ctttttgcat actgattttc 2167201 atttcacttc ccctttctaa atattgtaaa tacagactca gtatacatga agaaactgcc 2167261 ctattgttga aaatacatca atttgtcaat attttgaatc taaagtaata tagcttgaat 2167321 cttactctat tcattgccaa tcagccttag cccctctcac tgggaaggtc ccttgatttt 2167381 catactgctt caactttcat taacaagatg ccataaggct ttactctatt ttataatgga 2167441 agtgatcatc gaaaatcgtt agggaggtga tgtaatggca agcaagatga gaatgccaga 2167501 ttccgcaacg tcccatgcaa agcctactat tgggaaggcg atactttgca tggggtagac 2167561 tttctaaaag atcgcccaag taagcttttc tgatatagtg gctttgcacc ttatttgaca 2167621 taaaaaaata aggagctggc agaaatggca tatgtaaaag caaccgctat tttacctgaa 2167681 aagctgatat cggaaattca aaagtatgtt caaggaaaaa caatatatat ccctaaacct 2167741 gaatcctctc atcaaaaatg gggtgcgtgt tcaggaacaa gaaagctgat cgatgacaga 2167801 aacgcttcta ttaaaaaagc atttaaaaac ggcaaaacca ttcatcaatt atctgatgaa 2167861 tatcacctct ctattgaaac aataaaaaaa attgtctact ctaaataaac aaaacggaag 2167921 cactgataaa aaataatcag tgctttttat atggcgagtt tgtttcttag ttatttcctg 2167981 catatgatac cattggccaa ttgtgtaaag ttaagggaga tgagaagaaa ggaaggtcct 2168041 acaaatgacg ataaacaatg gaacgttgca agtacccggc gcgaacatcc actatcaggt 2168101 gcgtggctct ggtccaatca ttcttttggt ccacggagga ggcggtgatg ccgacaagtt 2168161 ccatcatgtt gccaatcatc tggctaactg gtacacggtt gttacttatg atcgccgcgg 2168221 ccattcccgc agcaatctcg ccaatcagat tgagggttac cgtgtggaaa cacacagtga 2168281 cgatgctcac cgtcttctag ccaaaatcac caataagccg gcctatgtat ttggaagcag 2168341 ctccggggct gttatcgggc ttgatctgtg catacgccat cccgaacaag tacatgtcat 2168401 gatcccacac gaaccaatct tattgcagct tctgcatgga aatgagctga aacaagccga 2168461 gcaattcatg gaagacctta agaaaaatca tcgaagtgaa gtcattaaat taatgtcaag 2168521 attagagaca gacgaacaat caaaggctgt cctgacaaag cggcttctcg gcaattcaac 2168581 gtatttcact gagtatgaaa ttcaaggaat tctcagctat acattagatt tcgaagcatt 2168641 aaaaactgtg tttacatctt caccgatgaa gatactccca gctggcggaa gtgcttctcg 2168701 ggagcttttt ccttatcgtt gcgcgaacgc cctagcggaa caattggaaa cagaatgggt 2168761 tgaattcccc ggaaatcata cggggtacac aatgtaccat aaagaatttt ctgagaggtt 2168821 acacgacatg ttagaaaaag aaaagaaaca tacgtgttaa ggattgatta aaattttcaa 2168881 aataggacag gtgaaactaa ctatggaatt ggagaagatt tcacgaagcg taaaaagaac 2168941 ttttcactaa cgagaacgca atgtgagatg tttaaccaaa gtgatattag ggatttcatc 2169001 gaaaaatagg tttgtacatt acgttctcct attgattatt tcctatctta attccgtatt 2169061 ttataccatt agatacaact ctaaagcggc tcgttatttt gtcctcaaca acaaccagtg 2169121 tctaacatca tgaatctctt ttgaaaatca ccacaaatgc aggtatggaa gacttcatcg 2169181 cagcaaaaac cataccaact attgttgttg gtatggttcg tcctagatag gcccttaaga 2169241 agagattcta ttgtacggag tatttagcta attgcatttg taaccgacag ggccgtctga 2169301 acctgtgtac acatatgtgt cagacacata tccaatattc acgacacccc gggaatcttt 2169361 ccactggatt tggtcccaga tattactcgt tccatacttc cctgtaacag tcgttccata 2169421 agcgtaacaa taataaggaa cacgggagcc actcggaatg gaaagcataa taggataatt 2169481 tgtaccagga ccgctgcgca tattgacagg cgcaccgctg cttgttgaga cagtaaagta 2169541 ctgaacggca agtgcctgac tggaaaaaat gaataaagat gcaatcatca cggttaacat 2169601 actcagcatt ttcagtttag tcaatgtcat ccctctttct tcaattcctt cattttaaga 2169661 aacgatagaa cataggctac cagctgcatt taggaacaac cggaccgtct gagcctgtat 2169721 acatatatgt atcagagaca aatccaggaa cgatctcccc gctggcaagc gtccgctctg 2169781 tgtaattcca aatattgctc gttccatact ttccagttac agttgtaccg gttttgtagc 2169841 aatagatcgg gatgcgggtt ccgctcggaa tggtcgttac aattccccaa cttgtacctg 2169901 ggccgctgcg catgttgaca ggagcaccgc tgcttgttga aaccgtataa tactgagccg 2169961 caagtgcatg gctagaaaaa atgaacacag atgcaatcat caccgttagc atacttagcc 2170021 tctttaactt attcacctta taccctcccc ttataaatgc cgtacgtttg actttcttac 2170081 atccagttaa ggatttactt tcagatacca tgccccctcc cctcccatat atttatcaat 2170141 gtaccataaa ctagatcttt caaaagtgga attattccta tgttttcgac aattaaggat 2170201 acaaaataaa tggtagtcag gcttgatatt gatggtgtgt tacatttggc tcttaatcat 2170261 ttgtccagtc ggtaatcacg attgacaatc aggaaaaagg acatggatca agcggcttcg 2170321 tttccaccaa ttaactcaat cagtgtactg cttccttgta tccacgcttc ttctcgattc 2170381 atagatactc cacctttttc accaatcaaa aacggacacc atacaaatca gcgtaaatgc 2170441 tgcaagttca gtgtccgcaa cctattatga ctttgctttc ttttaccagg gcgtgtaaaa 2170501 atgattaggt acgttatcaa acgttattct atgattttgc gagtcaaaaa atcataacat 2170561 tttatatatt tcaatcagat tatgatctgg atctctgaag tgagcaactc gggcactcca 2170621 ttccttgcga tcatgcggtt tattctcaca tttaactcct ttttcgtgta aatcgtcata 2170681 cgttttatca acatcttcta ccttaaactg aagcaaaaat tttgattgag cttctccttc 2170741 caaggacttt ttttcctctc caacgatttc agccatcgtt tctcgagata aaagctctat 2170801 tttcgtttcc ccattatcaa agagtgcata ttccatttca ttctctaacc aacttattgg 2170861 aagtcctaat gaatctttat aaaactcgac gcttttctta aaatcattca ccaacagtct 2170921 aatttgtaac agcttcatat cgagtgcctc ctataaaacc atacttttac tggtcatcca 2170981 atttaatgat accaaagaaa cctgacagca ctatgtcaag tttccatact tcacccttat 2171041 ttcagattta agtgcagttt agtccatgtc ataagaacga gcaaaaacag cgattcttaa 2171101 aacaaaaaat gataccgagt gtattttctg tatgcttcaa cttcatttcg ggaaatgtaa 2171161 cgttgataaa aggaggttac atcaatatgg atcatcaaac attggcagct catgaggctg 2171221 ttgacttaca tgaaatcgtg aactttaaaa cactttgtat agcgaaatca aagttaatgc 2171281 aagggcttgt gtttgaccaa gaactgaagg acttgatgga aaaagatgta cagcaatcca 2171341 ttcaagacct tactgaatta caagcggttt atgagcgtgc ctcatttcag gcccctgtcc 2171401 ctcaaagccg cccaacgcca atcatcaatt gaaagggagg taagcctctt tgaataatga 2171461 tcatttagac cccattaatt cgctgaatgt gcctgaacta gcagacacta cattcgcgat 2171521 ggattttctt atacgagcta aggaaggcgt aaggaatact gctgtagctt tgacagaaac 2171581 cgcttcacca gatgtaagag cactgcttcg gaaacagctg atgcaaggaa ttgcgatgca 2171641 ccaagagatt acggaactga tgatcagcaa aaagtggttc catccatatg agctgagcga 2171701 acagtataag ctggatcagc tctctgcaaa aaacacgatc atggtcggca atatgaacct 2171761 ctttcctgat gaaacaaatc gcaaagggat gtttgaccgg acacctgatg aacactaaca 2171821 ctggaggttt tacagcatga aggcagtaac gtatcaaggc attaaaaatg ttgttgtcaa 2171881 agatgtcccc gatccaaaga ttgaaaaatc cgatgacatg attatcaaag tcaccagtac 2171941 agccatttgc ggatcagatt tacatttaat ccatggattc attccgaata tgcaagaaga 2172001 ctatgtcatc ggccatgaac cgatgggaat cgtcgaagaa gttggttctg gggtgactaa 2172061 actaaaaaag ggagatcggg taattattcc ctttaatata gcatgcgggg aatgcttttt 2172121 ttgtaaaaac cagctggaaa gccaatgtga tcagtctaat gacaatgggg aaatgggtgc 2172181 ttatttcggc tattcagggc aaactggcgg ttatccaggc gggcaagctg aatatttaag 2172241 agtgccgttt gcgaatttta cccattttaa aatccctgaa tcttgtgagg aacccgatga 2172301 gaaattaagc gtgattgccg atgccatgac caccggcttt tggagtgtgg ataatgccgg 2172361 cgtaaaaaaa ggcgatacag ttatcgttct cggctgcgga ccagtcggcc tgtttgctca 2172421 aaagttttgt tggctaaaag gcgcaaaacg cgtcatagca gttgactatg taaactatcg 2172481 cttacagcat gcgaaacgta caaacaaagt agaaatcgtt aattttgaag accatgagaa 2172541 tacagggaat tatttaaagg aaatcacgaa aggcggagcg gatgtagtca ttgacgctgt 2172601 tgggatggat ggtaaaatga gcgatctcga gttccttgcc agcggcttaa agcttcatgg 2172661 cggaacgatg agtgcattgg tcattgcttc ccaagctgtt cgcaaaggag gaaccataca 2172721 aattacaggt gtgtatggag gcagatataa cggttttccg ttaggagata ttatgcagcg 2172781 aaacgtcaat atacgctctg gacaggctcc agtgatccac tatatgccgt acatgtttga 2172841 actagtatcg acaggcaaaa ttgatccggg agatgttgtc agccatgtcc tgccgcttag 2172901 tgaagccaag catggctatg acatttttga ttcaaaaatg gatgattgta tcaaagttgt 2172961 gttaaagcct taaaaaacgg aggttacaga aatggaatac gccttacacg aagtgcttga 2173021 ggttcaggaa atgactgcat ttaagacact ttgtttgacg aaatctaaaa caatgaaagc 2173081 actggtatct gatccgaagc tgaaagaaat catgcagcaa gatgttgata tcaccacacg 2173141 ccagttgcag gaatttgcct ctattttatc taatgcaaag caagaatgag gagatgaata 2173201 aatcatgaat cctatcatag aatatctgac tggcatgaat gttctaacag accaaatcat 2173261 tgctatggac ttattaattt cagcaaagaa cggagtcaga aattatgcga tggcagccac 2173321 tgaagccgga acgcctgaag taaaagaggt ccttatccgc catttggaag aagcactcga 2173381 tatgcacgaa caactctcaa gctatatgat ggaaaaaggc tggtaccatc cttggaaccc 2173441 tgacgaacaa gtcaagctga atttaaaaaa tattgataca gccattcaat tgccaaccct 2173501 ttaacataca atgactgatt tgctgaggaa cagtattgat tggccacaac tgttcctcag 2173561 cttcaaaatg agcactgttt gttcgggtcc tatgaccgta aatagattaa ccgcttttct 2173621 ccatctgatc tccgataatg tttgcaaatt ctccaatcca aataaggaat cgtaaccacc 2173681 tctttttatg cgatctcttg atggagaaaa caggccagaa acaaaatcct tcgtttttga 2173741 cctgccctct tcacacgcaa agaatgctac cttctttgct ccactgatcc gtgaagactt 2173801 tccgttttag gcctgctttt gagctttgcc tcattttcac gcaatttccc atcataatct 2173861 ttaatttttg tgtctaatct cttaattgtt tcatcaattt ctttccgctt ctctatcagc 2173921 cgctgtcgtt cgtcagccag gatatttttt cgagcttcta ccgtacggtc accttcggta 2173981 aataatgttg tatattcaat tagcgcttct atcgatagtc ccgcatttcg catgcattta 2174041 atgaattcaa tccatttgat atcttcttca tcatagtcgc gaatgccgct gtcttttcgt 2174101 tttacaggcg ggattaatcc tacacgttcg taatatcgga gtgttgcggc tgtcaggcca 2174161 aactgctttg ccacctgagc aatattcatg atcttcacct ctctatcctg tatgttgtga 2174221 aggtaacact taaagttaac tttaagtcaa gctcaaaaca agtggttagc tgctgaatct 2174281 gggtttatat attcgggact tgccttaaag cacactttaa actctatact tctccatgca 2174341 ctaaaaacag tgtagttgga gggattgctg aatggcaaat aaacacactg ccggaagaga 2174401 acaattagga gaatttgcgc caaagtttgc tgaacttcat gatgatgttc tattcggtga 2174461 catttgggca agagaagaag aactttcatc ccgggatcgc agcatgatta cagtttctgc 2174521 attaattact gactgtttct cagcttataa atcaggttca ttttaaatgg tttttttaaa 2174581 aaacccttgc cttaaagcag actttaaggt ttatcgttat gttgaagaca ccataaaaca 2174641 taaataagtg catgttttta tttacaacac ttatgatgaa gaaaggatag gttcgtatgt 2174701 gtaatcaaca tcaaacccgt gtattaagcg tgtcacatgc aaaagccaaa tttgaacaaa 2174761 cgacgattga gcgaagagga ttacggccgc acgatgtctt aatcgatatt aaattcagcg 2174821 gcatttgcca ttcagacatt catagcgctt ttgatgaatg gggcggtggc atcttcccaa 2174881 tggtgcctgg acatgaaata gccggtgttg taacagccgt tggaacaaaa gtcaccaagt 2174941 tggctgtcgg ggaccgcgtt ggtgtcggct gttttgttga ctcttgcgga gaatgcgaat 2175001 actgtctcaa cgcagaggaa caattctgca cgaagggtgt tgttcaaacg tataactcag 2175061 tagactacga cggaaacccc acttatggcg ggtacagcca aaaaatcgtt gtcactgaca 2175121 gatttgttgt tcgcatacca gatcgtttgg aaatggatgt tgccagtccg ctgttgtgtg 2175181 caggtatcac aacgtattcc ccgctgaaac actggaatgt tggccctggt aaaaaggttg 2175241 cgattgtagg cgtaggtggc cttggacatt tggcaattca atttgcacat gcgatgggtg 2175301 cagaagtaac cgtcctgagc cgttccatga ataagaaaga ggaagctctg gaactcggtg 2175361 caaatcatta ctttgcaaca agtgacccag ccacattcac tgcattggcc gggcgttttg 2175421 acgtgatctt aaatacggta tcggcaaatc tcgatgtaga tgcctattta tcaatgcttc 2175481 gtatagacgg gacacttgta agcgttggag ctcctgccaa gccggacaca tacagtgtgt 2175541 tttccctaat catggggcgc cgcagcattg caggttctct agtcggcgga attcaagaaa 2175601 ctcaagagat gctggatttc gcagctgagc atggcatcga acctaaaatc gaagtcatcg 2175661 gagctgacca agtggacgag gcatacgaac gtatcctccg aagcgatgtc cgttatcgat 2175721 ttgtgattga tatttccaca ttgtaatagg ttagtcctta tatgggctgc cgcttttatt 2175781 gaaactcacg aaaaatgatc tctttaagca aatattttga aggccggtca atcttcctgt 2175841 tattctatga atagagagtt attaggaggg ttttttatga gcaaaaaaat tgcagttctt 2175901 gttacagacc aattcgaaga catcgaatat acaagtccgg taaaagcata cgaagaagct 2175961 ggctacagtg ttgtggctat cgatttggaa gccggcaaag aagttaccgg taagcatggc 2176021 gagaaagtaa agattgacaa agccatctct gatgtggatg caagtgactt tgatgcactt 2176081 ttaattcctg ggggattctc tccggatttg cttcgtgcag atgaccgtcc gggtgaattc 2176141 gcaaaagcat ttgtcgaaaa caaaaaacct gttttcgcaa tttgccacgg cccgcaagta 2176201 ctgattgata cggatcttct aaaaggcaaa gatatcacag gctaccgcag catccgcaaa 2176261 gatttaatca atgccggtgc aaactacaaa gatgcagaag tagtcgtcag ccacaacatt 2176321 gtcacaagca gaacacctga tgatttggaa gcatttaacc gcgaatcttt aaacttgtta 2176381 aaataacaag aaggcacaga ctgttcgggt ctgtgccttt tttaaaatta agactccttc 2176441 gttacattct gaaagacagc agtcgcgtcc cacacattca agccaaattg gccttctgaa 2176501 aatacggaat catgtgcatc aatcacaaga cgatcatcta aatagatttt aaagcgatcg 2176561 ccctcggcct ctgttttcag atgatacttt ttattaacgt ctatcggtgt tttgtattca 2176621 gcaatgacag aagcagcacc gttctcaaat ttaaagaatt tcactaggtc atgcttcgca 2176681 tccacattgg caaggtaacc gtttttggca tctttgtcag agcgaaacat tagtgctcct 2176741 gcccctcttc cgtttccatc cttaatggtg atatcagatt cataagtgaa gtctgacccg 2176801 gatgctgaag acaagataaa ggaatcgccg tccgacctcc cttgtttccc ctcaattgtg 2176861 tctgcccacg tgccatttac agtcgtccag ccagtcatat tggacataaa aggtgtcgtt 2176921 ccccatacct tttttaaagg gtgtatcgtt aaagatttta cctttacacc gccatttgca 2176981 gcatataatt caagcccttt gcttgatcgg tctgggagaa taatatccgt tatgacctgc 2177041 tttccgtcat tcccaaatac ttcaaccgag gagcggtcaa caaaaatgcg caacttaacc 2177101 ttcccattta ccggcttcaa cggggctgtt tcttttccgg tgttaaaggc cggattaaag 2177161 gtgtcgttgc ctgactcgct ccggtcaacg aacaatttgg cgttccttcg gtcatagccg 2177221 accttcgtaa attgattttc acctgttcgg accttaaaac caaattcagc agctgaacca 2177281 gggcttactt taaattctgc atttatttca taggcatctc cagattgccc cgctaacaca 2177341 ttatgacttg caggcgatat ggtcagattc ttccacttct tagaggttcc gcgaatggtt 2177401 tccagctctt tcaccggtgt ttggaccact ctaacccctt cggtaaacgc tttcaatttt 2177461 aactctcttg gaatggacgt tgcacttctc catggggatg tcggaacatc attcgcatat 2177521 tgccaattgc tcatccaccc taaccatagc cggcggctgt ctgtggatgg aatatcagac 2177581 caggatacag ccgcataaaa gtctctgccg taatccgtcc agagaacttt gtttggcggg 2177641 ttttcatttt taaaatgagt tccatcaaag tcccctacaa aatattgcat gcctgatcct 2177701 cccgagaccg ctccgtttcc gacactgacc tgcatgaccc atttcttttg attcggattg 2177761 ccgtctaccg gaagctcaaa taaatccggg cattcccata ctcccccgtg gcttccttga 2177821 tcctgtccaa attcacttgc atacgtccac tgcttcagat tttttgatgt ataaatgagg 2177881 attcggtcac cggccgcaag caccatcacc cacttttttt ctttctcata ccaaaagact 2177941 tttggatcgc gaaaatcttt tttacccggg tttggaatga cagggttgcc agcgtacttc 2178001 gtccatgttc ttcctttgtc gttgctatag gcaatacttt gcacttgatg gccttcccga 2178061 tcctgtgtat aaatggccac aagcggcttc tctttgcctg tttgaaaacc gcttgtgtta 2178121 tttttatcta caactgcgct tccagaaaag atcgtgcctt tttcatccgg atacagcgca 2178181 acaggaaggt gttcccatgt aaccaaatct ttgctgacgg catgccccca atgcatgggc 2178241 ccccactgaa gcccgtatgg atggtattga tagaacaagt gatattcccc agcataatat 2178301 accattccgt ttgggtcatt catccagttt gcctccggtg tgaagtgata ttgaggacgg 2178361 taatcctcat catagtagct tgaatcggct gcatctgccg aaaatgccat agtcaacagc 2178421 agggtgaaca tgatcatgac ttgaatcagt ctctttttca tttgttcctt cgctcctctc 2178481 ttcatgtttg aacactttca aaagagactg ctgcgcaagc tggtccgttt ctggcaattc 2178541 tcctctgttt cactgttatc cgaatgattt atatatgaaa agactgctgc agtttctctc 2178601 tctttccttc acacacctta tgctaagaat ccagcccaat acccgagaat cccgatgaca 2178661 aagatgccgc aaataatgag aagtggattc acccctttgc gaagcatcca tgccaccaat 2178721 aacgttaatc cgagaggcag cgcccccggc ataatgctat ctagcacgtt ttgtaccgtt 2178781 tgaacatcta cttttccgct ttcatcctta atcctggata caacgattgg aatgttgatg 2178841 gtggtccatt tggacacgag agcccccata acaaataacc cgagaatcga agcgccctct 2178901 gtaagctttt gaatgcgatt ccccgctaaa tcctgaagaa tctccattcc tttcacatag 2178961 ccatacttta atccgtaata ttttgtgctt aatcttatgg cattcagcaa gaaaaagaat 2179021 agcaaaggac cggcaatgtt tcctcctaaa gcaagggagg ctcctagcgc agctaagaca 2179081 ggacgaatcg ttccccaaaa aattggatcg cctacgcccg ctattggtcc catcaaaccg 2179141 attttcattc cgcttatcgc ttttccgtca attcctttat tgttcgccat ttcttcttcc 2179201 atggctgccg tcacgccaaa tataggcgct gtcagccacg gatgtgtatt aaaccattcc 2179261 aaatgccgct gtaaggcttc gtttcttttc gctccgggac cgtacaattt tttgatcgcc 2179321 ggtatcatga cataacaata tcccattgcc tgcacacgtt cgaagttaaa ggaaccgagt 2179381 aaaaaatttg aacgaataaa catgctgaaa atttctttct tcgttaatcg tttttctttc 2179441 tccatttttt cttccccctc atcgtttagg catcaagatc atcatcatcg tcatcataaa 2179501 cagcaacact gccactgtct gatgcggccg cgactgctcc gtgagcgctt tgtttttgca 2179561 tcacctgctg gtataaaagc gccagacaga gaccaagggc tccaaatccc actaagttaa 2179621 aatcggtaaa cgccgctaat aagaaaccaa tatagaaaaa tggctttaaa taaggaatat 2179681 tcatcatatt gatcaccatg gcatacccga caaccacaat aatgcctccg cctatttgca 2179741 gtccttttgt aatgacatca ggaatatttc ccaggaacgc ctgaacagcg ctgacactaa 2179801 ttaaagcaac aatcaatgta ggaatcatga cgcgcaaagc ttgaaacacc atcgcggtaa 2179861 tatgcataat ttcaattcct tttatatttc ccgcttttgc atattgatca gcgcggtgga 2179921 tgaaaaagac agtgatcgtc cgaacaaaaa tcgtcagcgc ctgacccgca gctgctaaag 2179981 caacagcgac agcaatccct tcgccaattc cttgatcagc ggtaataact aaaatggttg 2180041 agatgacaga ggcgatcgct gtatcaggtg ccatggcaag cccgacgttc atccagccga 2180101 gcgccatcag ctccagtgtg cctccaagaa taattcccgt ttttaagtcc ccgagcacca 2180161 agccaaccaa cgtacaggcc actagcggcc ggtgtgtctg cccttcatcc aatacacttg 2180221 cgattccggt gattgctgca atgattaaca acaaaataat ttgtaatgaa gacatattct 2180281 catccccttg attattttgt tacgttccgt aaaatctgta caaaatcctc actggcatct 2180341 gaaggcagct gcctcaattc cagtttcacg cccttgtcac ttaatgtttc aaatgccttt 2180401 atatcttgtt ctgtgacact gactgatttt gtgatttgcc tgcgatgatt ttcaaaacgc 2180461 attcccccga cgtttacggt tttgatcggt acacctgctt ctataagaga tacaatatcg 2180521 gacggatttt caaacaagag cattgccgtt accccttcgt agcgcggact atgaaatgct 2180581 tttgccattt tagaaaccga gacggcactc gcctttacat ttgaaggcgc aacagaaagg 2180641 atcagcgttt ttctcatttc gtcctgagca atatcgtcgg agacaacgat gattcggtcg 2180701 gctgcatgga cttttatcca ccttgtcagg atttggccgt gaataaagcg gtcatcaatt 2180761 cttgctaaca caatgttcat cataattcat cctctcttgt atcttgattg gctgttttta 2180821 ctttttctaa atgttcactg cacacttgaa agctttgctg actcattgct tttaagttgt 2180881 tcagcaaatc tttgagagcc agatgttctc tcaggcttaa tacctccagc agaatcggca 2180941 ggtttacgcc ggcagccata tccattcttt gatcctcagc aataaaggaa gctgccgcgt 2181001 tatatggcgt ccctccaaaa atatcgacta aaaaaagcac ttcatgttct tccgggatat 2181061 ccttgagcgc ctgatgatat ttttcttgca gcgtttgtat tccttcccct ttgaaaaacg 2181121 gcactgcaat caggttattt tcttcaccga atatcatccc tgaagactct tttaatgcta 2181181 tgggaaaatc tccatgaccg ctgataataa ctgaaatcat atctattgct cctttcctgt 2181241 tttgtacatc catatataat gcaaggatcg tgccaacaca gttgtgttaa gcgttttcat 2181301 tgttatttca gccaatagca atttgttgtt gaaacactta aaacgaaaaa aataaacctg 2181361 tattaaaatg gtgttccatt taatacaggt tcatatgaaa aaactgtttt taaaacagct 2181421 ggccatgcac ttcttcagca aatatggcgg ctataaataa tttttcatca tcacttatgc 2181481 gaagtccgag cttttcttca taaggggcta atgttcgctc tgtcacgtac accatttcct 2181541 tcagctgatc attgatctct tcttcctctg agaaagcgat cggattctgc ttaattaccc 2181601 tttcaaaggc gaaagccgtg tgcataatga ctttgatcaa aaccgcatta ttgaaaatga 2181661 cccccagctc atcctgaacg gtttgcagcc actccaataa catgtcgatc acatggtggg 2181721 gattcaagaa gacaaggtat tttttcaggc tatcctcgca aagctccctg acaataatat 2181781 ttgcttcgtt caatccattg ctcaaggaga tgcttccttt tgtaatcgcc tgttgaatca 2181841 gcttctctcc ctccccttca attaacactt ctaaagatac atgcggagca ttgattttag 2181901 ggtctttcgt tccgactgtc gcaaggattt catactcttt ttcgatttct tttatgctgt 2181961 tggccagctt aatcgatgat acggtcaata tgtgaatggg ggtatcggag gccttgttta 2182021 cgatcgtggt tagaatgtct tccagctttt tggccgttcc gctacccgtc gtgcagatgg 2182081 ataccaatgc cttctttttg ccggatgccg ctggctgacg ctcccacaac tcgataaaat 2182141 ccttcgtgac cgattgatag atcgcatgca aatttaaatt caaatagttg acctttctga 2182201 cagcatccag caccattgaa gtcgtaacat tgctgatcgt tttaatagaa atgcctgtct 2182261 tttcctccag cctgctttcc agcattgcaa gcgaccccat atctaccagc attaaaacac 2182321 cttcaccttc atcaacctgt ttcatttttt ctgctacgca ttcaagaatg tccgaaggtg 2182381 aaacagtaag cggcatgtca actgctgcaa tcggcgtact ccctagcagt tctgtcgcga 2182441 cttcaaccat tgaactcgcc gtgctgtttc catgagctgc cacgataata ccgactcttt 2182501 tgttctcctt taacgatttg atggaatgaa ttaacatcgt taagtagatg acttctattt 2182561 caggaatagc cactttaaaa tattcctgaa ttttatcttt aaaaatcatc gccacccgat 2182621 attctttcac atgggtatca cgaatttcat ctgtctcctg tgtattcaaa acatcaattt 2182681 gctttcctcg ctttaaaaat gcgtcaatat gcatactcaa gaaataaata aacttacggt 2182741 caaatgtgca atccagctca tgttcagcta tttcttttaa ctgttttgtc atttgaatca 2182801 catcgtcttc aacgaatgtc agcaggttgt ctttttgaaa agcttgatga tgaaaaaaac 2182861 ttctgacatg caaatggaca tcagtcaaga tgtactggtt aatatccttt ttggataaac 2182921 cttctttcat aagcgttttc actttttcct caatcaaatg atataagtta aatgagaggt 2182981 cttcgtcaat ttttgttgtt tcatcttcta caatcggaga gataatcgtt gtaatattga 2183041 catattcaga aatggctttg cttctttgca tgtttttgct gctggacatc cattcttgct 2183101 tgatttcatc aggcagatcg cgaacagtca gttcaataac ttcatttctg tcaaggttat 2183161 gcaaaaatcc gtgtgcgcaa actaactgaa catttgattt cagctgtccg acattcccaa 2183221 atttcgcaga gtgaataagc gcattataga catcgatatg cacactcaga ttcttcttaa 2183281 ttcgctctgc ttctttccct aataaaaacg tcgtcagatc cactctttca ttaagcgatc 2183341 gttcttcaag cgaaggaata tgaatggtca ttgggattct tcgcaaaaac gttttcaata 2183401 gtgcagaact cggattttct gtagtcgcac aaataaacaa tacgttcgat gttcgtttat 2183461 gttcagattc tccaagcctg ttataagaac cgctgtcaat aaaataaaac agcatttctt 2183521 gtccctcggg agggagacgg tggatttcat ccataaaaag aatgccccca ttggcctgtt 2183581 cgactaaacc cgccttatcc tcggcagcac ctgtaaatga accttttttg tgtccgaata 2183641 attgagaaag caataattga gggttgttgt agtagtctgc acagttaaat gtaataaatg 2183701 gtgcgccggc cttcaatatg tcagagtaaa tggcaaactg gtaaattcgg ttcgcaaaaa 2183761 gggatttacc ggaaccagtc ggccctagga ggagcatatg cagaccgttc ggcggataaa 2183821 agacagctgc ttttgcctgg gagatcgctt tcttcaaact cccttttgcc cctatcataa 2183881 gctctagggg attcgtggaa atgtgttgat gattttgctt tgaatttccg gaaaacgcct 2183941 gaaggtcttt cacttccatc atctctgtat cccatttctt gttgaataat ttttctgcta 2184001 tctcgactgg gatgtatctt acaggaaatg ttttaatttt gatgaccttt ttggaccgga 2184061 cgagattgtt caattcaaag ctgacattgg accgctccat tttcagctgc tcggcaatct 2184121 cctttgctga attcccttgt atttttaaaa gatgatctaa ggttgaatca tgaaaattat 2184181 gcttgagctg atggtatatt ttatctattc ttctcacgtc tatcatcctt tgtccttatt 2184241 agataagcca ttaacaagaa tatttcgaaa ctttatagtc cgcgttgaga tttacacgtt 2184301 taaaaaggtc tctatagcag attgacaaag ctggctttta tgcgtatatg tttacatgtt 2184361 gaatcatttg cacctcatat tagtatgata gatgctcagt tctggagggc cagtcccctt 2184421 caaaagtaat aatcagtaaa cagtttatca ttctcgggga atgtaatgat gtcaaaataa 2184481 tcaatgacaa aaaatgaatc ttatagatca tgacaaatta cccaaatata accccttaag 2184541 ttcgttcaca actaaaaaga cggacactct atgtgaccgc cacagtatta caatttgcaa 2184601 aacttcgtca tttttgcaat ccacattgga ggttaaggaa tctgtaagct taaaaacttt 2184661 atctccgatc ctatcgattt gatccccctg ccggcctcaa tcatagtggg tatgcaatta 2184721 tacaaatcgt taccgattaa aactagcctg tcagattgtc caaatgactt tcctgtttta 2184781 ctctgctatt caggtagaat cacgagtgaa aaatagagcc acaagacatg taacagcact 2184841 taaaatagtt ttaaaattta aaaataaaag tatctattct tttaaatgtt ataatatccg 2184901 ataaaacttt actcatcttt ttattactgg aggaaaataa aattgatagg caattctagc 2184961 aaagacaatt ttggccagca acagaaattg tctagaggcc ttaaaaacag gcatatacaa 2185021 ttaatggcga ttggaggtgc aatcggtaca ggtttatttt taggttcagg taaatccatc 2185081 cattttgcag gaccatccat tttatttgct tacttgatca ccggcgtatt ttgctttttc 2185141 attatgcgtt cgctcggaga actgctctta tcaaatgcgg gataccactc ttttgttgat 2185201 tttgtaaggg actatttagg aaacatggca gcatttatca ctgggtggac ctactggttc 2185261 tgttggattt ccctcgcgat ggctgattta acggcggtcg gcatttatac gcaatattgg 2185321 cttcccgatg tgcctcaatg gctgccgggt cttcttgcgc ttattatcct gctgatcatg 2185381 aaccttgcca ccgttaaact tttcggagaa ttagaatttt ggtttgcatt gatcaaagtc 2185441 attgccatac tggctctgat cgtaactggt attctcctga ttgcgaaagg tttttccgca 2185501 gcttccggcc ctgccagcct caacaacctt tggagccacg gcggcatgtt cccaaatgga 2185561 tggcatgggt ttatcctatc tttccaaatg gtcgtcttcg ctttcgtggg tattgaactt 2185621 gttggactga cagcaggtga aacagaaaat ccccaaaaag tgatccctaa agccatcaat 2185681 caaattcctg tccggatttt acttttttat gttggcgcac ttttcgtgat tatgtgtatc 2185741 tatccttgga atgtgttgaa tccaaacgaa agcccatttg ttcaggtctt ctctgcagta 2185801 ggcatcgttg tggctgccag tttgatcaat tttgttgtat taacatcagc cgcatcagct 2185861 gcaaatagcg ctttattcag cacaagccga atggtctatt cacttgcaaa ggatcatcac 2185921 gcacctggac tattaaagaa attaacttct tctaacgtgc caagcaatgc gctgttcttt 2185981 tcatccatcg ccattctgat tggcgttagt ctgaattatt taatgcccga gcaagtcttc 2186041 acgctgatta caagtgtttc aacaatatgc ttcattttta tttggggcat cacggtgatt 2186101 tgccatttga aatatcgaaa aacaaggcag catgaagcga aagcaaacaa atttaaaatg 2186161 cctttttacc cattatccaa ctatttaaca cttgcatttc tcgcgttcat tcttgtcata 2186221 ttggcactgg cgaatgatac acgtattgct ttgtttgtca ccccggtctg gtttgtttta 2186281 ttgattattt tgtataaggt gcaaacccgc agaggacata aggtgaaata aaaaaaagac 2186341 aagggatact cactcccttg tctttttata tgtgtcaaac actaaattaa actttggttt 2186401 caaatttcat tcacttcatt taagtgttaa ctcaaaccag ttttgatgcc gaaacctact 2186461 aatattattc cggtaatttt ttgaaacact ttctggaact tcgagttttt catccatttt 2186521 tttgcgtaat caataatata aacaagaaac aggaaccaca acaccgctaa taaggttagg 2186581 attgaagcta aaatgatgag ctgctggttt atatttccgt tcaaattgat aaattggggc 2186641 atgattgtaa catacaccaa aacagtttta ggattgagaa tgttactgag tgatccctgc 2186701 ataaaggaag ttttataata acgtttcgga gaacttgcca tattttttgc ttgggattgc 2186761 atgtcatcta acgaaaacat acttttagca aaaaaacttt ttacacctaa ataaattaag 2186821 tatgccgctc ccaaatattt gatcgttgtg aaaagaatca ctgactttgc gattaccact 2186881 gataatccta aaatggcaat caccgtccaa aaggaaagtc ctgtcgccaa tccgagaatg 2186941 ttataacggc cggctttcgg accataccta agcgtatttt tcatcacaag catcgtatct 2187001 gcccccggta tgataaccat catggcagcg atcggtatgt atgcgagtaa gctgtgcatt 2187061 gttctctccc cctttaaaaa tcccctcaat catatagtga ctacaaaagt aactacttat 2187121 aaaagtgtat caatgcgttt ggaataaatc aatatgattt gttaaaatag cgattactaa 2187181 ggcagcgatt gctctttata ttggaggata tatgaaagaa aatatgttag acattttaaa 2187241 aaacctcaat tttacagaat atgaatcgaa agcgtattta gcattattgc aagaatcacc 2187301 tttaacaggc tatgccgttg ccaaaaaatc cggagtgccc cgttctaaaa tttatgaagt 2187361 attggaaagt cttgtcataa ggggagatgt ttttgtcagt catggaaata cgcctcagta 2187421 tgttccagtc cccgcaaaag aactgattaa aaaccgccgg ctcaaagcgg aagagcattt 2187481 tgatcaggct gagaaatatt ttgaaaagtt cgagcagacc gcaaatgacc gggaaaacat 2187541 ctggaatatc accggccgca gtgaaattct tgaaaaggtg aaggcttgta tcttatctgc 2187601 caaaaaaaga atcctcttag aaatatggaa agaggatttt aaggagatag aagcagagct 2187661 caaacaggcg gcagaacaag gcgttattgt caccattatt gcgtacggag acatcgtatc 2187721 tgattttgcc aatgtttacc ttcatgatat gagcagtgaa attacagaag agtatgacgg 2187781 acggtggctt gtctatagcg gagatgattc agaagtagta gcgggcattg tctcacttgg 2187841 caacgacagc cgtgctgcat ggacgatgca tgtagggtta gtcatgccta ttactgaagt 2187901 gatcattcat gatctgtacc tcatggaaat tctgaaaaag catagagagc ttttagaaga 2187961 gagcttcggg aaaaatctca tccagttgcg ccgtaaattt tctattcact cagatttcaa 2188021 aaaacattat ttggaataat gtttgtcatc tcttacccca aaaacaaggc ttgtacaaaa 2188081 caagccttgt ttttttatgc ataaaccccc catgctgatt tacttctctc ttttaaaaaa 2188141 tgtgattctg cgcaaactat ttttcagcct gccgcgtcta tcctaggtaa cagcctacga 2188201 tatacgtata ttcaaaaagg agccctttat tgcaatgaag aaaaaacaaa caacaaaagc 2188261 gttgcttgtc acatgcataa ctgaccataa gcaagatttc tacaggttgg ctttcagtta 2188321 tgtgaaaaat caagatgacg cattagatat tgttcaggaa tctataaaaa aagcgctgag 2188381 ctcagttgaa acggtcagga accctgagac gataaaaagc tggttttata aaattttagt 2188441 acggacagcc attgactttt tgcgcaaaca aaaaaagata agagtgatgg acgacgaaac 2188501 gatagaattt ttaagcaaag gaaaggaaga ccattacaag gatactgatc tccatgaagc 2188561 gcttgacgaa ttgccgtacc gctataaaac cattattatt ttacgttttt ttgaagacct 2188621 caaattagaa gaaattgcgg aaattacagg agaaaacacg aataccgtca aaacgcgcct 2188681 atacagagca ttgaagctga tgcgcattca gttgacgaag gaggatcttt cttaatggat 2188741 aagagattac agcaattaag agaagaatat aaaaatgttc agattcctaa agaattggat 2188801 atcattgttg aaaaagccct tcagcaagaa ccaaaaaaga aaagaatcgt tatgtggccg 2188861 acatcagcag caatcgctgc agctatttta ttcactgcgc ttgttaatat caacccggac 2188921 gccgctcagg ctatgtcaaa gatccctgtc atcggcaaaa tcgtcaaagc gatcaccttt 2188981 attgaaatca aagaggaaaa agaccaatca agcattgatg tcaaaacacc tgctttgtcc 2189041 gggctttcta ataaagagct tgaaaacagc attaacgaga aatacttgaa agaaagccag 2189101 cagctgtata aagagtttat acagtccaca tccaaaaaca aaaaagggca tctcagcatc 2189161 tacagtgatt acgagacggt cacagacacg ccagatttac tctctatccg gcgcaatatt 2189221 gaaacaacac aagcatcttc ctacacacaa agccgttata ttacaattga caaaaagaat 2189281 gatattttac ttacattaaa aagcttattc aaagatgagc gctatatcaa agtcatcagt 2189341 caaaacatca aagaacaaat gaaacagcaa atgaaggaag atccaaataa aatatattgg 2189401 ctcactgacg aagatgcaga accgttcaaa acgattcttc ctgatcagac gttttacatt 2189461 actgaagacc ataaacttgt gatctcattt gacgaatatg aagtcgcccc cggctatatg 2189521 ggcgttacag agtttacaat tccaaccggc gtcatttcaa acttgctcgt gggagaacgt 2189581 tatattcgat aaaataaaaa catccatcta agattatgga tgttttctct cttctctatt 2189641 cgaggtcgta accccgctat caaaaacaac gagaatattt gcatactatt ggaggaatac 2189701 ccatgtatca caagacacag catcatcgat acattcctgg acttgatggc cttcgggctt 2189761 tcgccgtcct gtcagttatc acttatcacc taaatttcaa ttgggctaac ggtggtttta 2189821 tcggggttga tatctttttt gttttatccg gatatttgat tacatctatt ctattaccgg 2189881 catatggaaa tgatatcaat cttgattttc gggatttttg ggtgcgccgc attcggcggc 2189941 ttctcccggc agcgtacctt atgatctttt ccactgttgt gtgggtcgta ttgtttgatc 2190001 gagaactatt gcacactgta cgtggagatg cgatctcttc tctcttttat atgagcaatt 2190061 ggtggtttat ttttcacaag ctatcatatt ttgatagttt cggttcccca tcacctctaa 2190121 aaaacctttg gtcgctggcg attgaagaac aattttatat catatggccg atgtttttag 2190181 ttgttggaat gtacataatg aaaagccgcg ccagattggc tgcggtgata tcattgcttg 2190241 tgctttgttc agccgtgatg atgagcgtac tgtatgaacc tggcggagat ccgagccgcg 2190301 tttactatgg cacagacact cgttcgtttg aacttctcat cggatgtgcc ttggctttgg 2190361 tatggccgat gaaaaggctg tcttccaaca ggctgccaag caaactgaag cacactttgc 2190421 acgccactga atttttggca ttttgtattt tagtgttgtg tgtctatttc acagatgaat 2190481 acgagccttt tctttacaga ggcggaatgc tattcattag cgtgactgcc gcaatcctta 2190541 ttgcatgtgt ttgccatccg agcagctttt taggcaatct gctttcatgg aggccgcttc 2190601 ggtggcttgg aacgaggtct tacggaattt atctttggca ctaccctgtt attgtgttaa 2190661 gcacgccagt tcaagaaatc ggaaaccctg ttttttggca tatcgtgcta aaggtcattg 2190721 tgacatgtat acttgccgag ctctcctacc attttattga gaagccgata cggacacagg 2190781 gatttaggtc attttcccgc cgtgttttta tacatagaat caaggaatgg aaaacgacat 2190841 ctgtcatcag caaaatgtca attggtttca ttattttcgc tatacttatt tttgcaggcg 2190901 ggctgtcagg gctagccggc gagcaaaagc accctaccaa atggacctat agctcacaag 2190961 aaacaaatgc tgacaccagc caggcttctg gggataaaaa gaacgctgca gcagataaaa 2191021 aacacaatcc tgaacaaaag acaacagatt ccaatcaggg tcaaaaggaa aacaaagata 2191081 gtgggcaaga gactcataaa aagaaagaca cgcaatccca acagttgaaa aaaccagcag 2191141 acactgcgaa agaagtttta gctataggag attccgtcat gcttgatatt tcttcacacc 2191201 tgcgtcagtc attttcaaat gtgacgattg atggaaaggt agggagacaa atgtctcaag 2191261 ctttggaact cgcaagggaa tacaagtctt ttaatcagcc gaacaaggct gtcatcattg 2191321 agcttggaac caatggctat tttacaaaca gccaaatcga acaactgctt caatctttct 2191381 caaaagctca tatttatctt gtcaatacac gggttccccg ccaatgggaa agcaaggtaa 2191441 atgaatcttt gcagcaacag gcccacgcac atcaaaatgt tacgttagtt gactggcata 2191501 cagaagctct tcagcatccg gaatatttta cccctgatgg tgttcacttg gttcctaaag 2191561 gggcaaaaac tttgactgct cttattgttc aggcgatgaa atcgtaaaaa agagatccta 2191621 tacagatcac ttttttactt tagtttctga tcgttgatta tgtcttcttt cagcaaggca 2191681 gcccttatgt ttacatgccg tttacgtaag ggtaagccaa aattgaatgg agggatgata 2191741 atgaaaggaa atgaagaaca tgacatccaa aaagagttga aacgatatga gctttttttc 2191801 aaaaaacgat ataaggttct ttatacagta aacgatttta tcatcggtgc tatgtttctc 2191861 gttggaagtt ttttcttttt ttatgaccgg ttaatgtcgg cagggatatg gctgtttgcg 2191921 atcggaagtt tgctgctgtt aatcaggccg accattcggc tgattcatga ctttcattac 2191981 cgtaagcatg tggaacagca attcaagcat caatcttcaa cagatgactg atcttaagga 2192041 ataagaaaga acaaaatgcc aaaagcctga gtcgaaaatc aaaaacaaga ctttcagact 2192101 atttattttt aaaaacaagg taaaaagaac taaacttttg cctctgcatg ccgatatgaa 2192161 taataaggcc ggcgcgatac tccctataac atccttttca gtagatttca ttatcgtgcc 2192221 ggttttctca tatgcaaagc aatcccgcca atcagattgg cgggatttta tattttacat 2192281 tcctgtccaa acgtctttca cataacgtct ttgatcttgc agcttttgca gccatacagc 2192341 tgattcttcc tgacttgctg ctttttcagc ttcatatgcc aatcgcaaag ttctctctac 2192401 atcaggagcc atttgcgatc catcaccgca tacgtaaata tgagcccctt tttcaatgag 2192461 tgtcatcaat ttctgcgtat cttgcttgag caagtgctgg acatatcctt ttggttcgtt 2192521 ttcgacgcgc gagtagcatc ggcggattgt gaccaaaccg tcctgttccg cttgatccag 2192581 ctcttctctg taaaggtcgt catggtccgg gcggcggcag ccgaagtata aaagtgcttc 2192641 accaagggtg cttccttcct tcttcaaaac cgatcttgcc tgaataaagc ctctgaatgg 2192701 cgcaattcct gtgcccggcc cgaccataat cataggcgtt tcaggatcat tcggcatctg 2192761 aaatccggac tgcggcgtac gaatgaagca agctgctgca tcacctgtat tcaattctgc 2192821 taaataatta gaggcgacac cccggtattc acctcggccg ctccatgctg aggctttcac 2192881 aactcctacc gtcatgctca cgatatttgc atgaactttc ggtgagcttg aaatggaata 2192941 gtatctcggt tttagtgatg gcaaaagtgc taaaaaccgt tcaaacggca tttcgcaagc 2193001 aggataatcc tctaaaaaat caagcatggt aagacgtttt gcaagtacct gctctttgta 2193061 aatgccatca tctgaaacga gctgttccag ctctttttga tgcggcggac aaactgtata 2193121 agaggccagc tcccgaagct gaagccttga tgccggttcc tgcagctcta cataggacga 2193181 caataaatcc actactttga ttggccgatc catcggcaga tgagccatat gagcgcttcc 2193241 gcttactttt atcacatgat tggactgcaa accgaatcgg ctgagaaccc gctgaacaag 2193301 ctccctgctg ttctttggca ggattccgat atgatcgcct tctttatatg ttttaccagc 2193361 cggaatttcc aattcaatat ggcgggttga acgcgtgctg gcagctgtct ggagttctcg 2193421 attctctaac acaatccctt caaacgcgcc atatgcttta gcaaccggcg tttccgtcgc 2193481 ttcactgaga aaagtaatcg ataatgaagg cctgtcttct ttctgggcta tttcgttaat 2193541 atcaaatgcg tccatcgttt ccttccagaa gcggttttcc caagactcgc ggtggctttc 2193601 aaaatcatcg gcggcgtcac cttccccaat cgctgttaaa cgcgatgccc cctttgcttt 2193661 catcatgtca tcaatcaggc ggggaatccg ctgatacgtg ctggcccagc tccggtttcc 2193721 gcagccgaat accgcatagg aaacaccttt caattggcct tcctcaagct ctttcagcca 2193781 ctctacaaat ccggcagcat tatcaggcgg cgccccatta taagaagccg ttacaatgac 2193841 gactgcccct tcttcaggga gcttgccgat ataatcatca agcggagccg tttcagctgt 2193901 aaagcccatc tggcggcctt gagcagccag ttcaccggct attccctcag ctgtcccaag 2193961 atttgaacca aaaagaacaa gtaaaggtgt gccgtgttta ggtttggttt cttttggctt 2194021 tgtttctgct ttgatgtctg cctgttcttt tctctgtaca ttgattgccg ctgtttttcg 2194081 cggtttcaca gtaattttaa aatcatccgg cttgatcgtt aatgcttctt tgatttttag 2194141 ttcgtagcca gtatggttta tcaattcaaa atgctttaat acaagaccga gaaccattgt 2194201 cgcttcttga agagcaaact gcatgccaat acaagcgcgc tgtccgtttc caaacggctt 2194261 atacgcatgg tgagggatac ttgaaggatc ctcaaaccgt tccggacgga aatcttccgc 2194321 atccggtccc caagcgtttt gatcccggtg cagttttgga attaaaacag tgactggctg 2194381 ccctttgctg atcggatatt ccccgcctag aacagtatcc tccttcgcat atagagaaaa 2194441 agccggagct gttggataca gtctgagggt ttcatttaaa accatccgaa tgtatttgag 2194501 ctgctggatt tgtttatatt caggcgtgtc atccgttaac acgcgatccg cttcctcctg 2194561 agcttttttc agtttttccg gatgtgtaag cagacaataa atcgcaaagg atagcaaccc 2194621 gcttgttgtc tcatgtccag caattaaaaa tgtgatgatt tggtatcgaa tgttttcgtc 2194681 atccagcgtt tcacccgtta ctggatcttt ggcataaagc atgagagaca agagatcctt 2194741 aatgttttca tccggattcg cctttcgctc cgctatcatt ctatcaacca gggagttcat 2194801 gacttctata tccttttgga actgcagctt cgttttcacc atcattttat cttgcaggcc 2194861 cagtcttttc gattgattca tcgcctcttt taaggcacgg agcatactgg tgataaacgg 2194921 atgctgtgaa tcacggtaaa agctgttgaa tcgatagtta aacccgcata acccaatcgt 2194981 atcaagcgtc agacgtgtca tatcgtccgc tacatcaatt tcttcattag ggtttaaccg 2195041 gctccacttt tgaatcagct gggttgcgat atccagcatc atagaatgat agcctttcat 2195101 cgctttttga ctaaaactcg gcagcaaaat gcggtgggct ttttgccagt tcggttcgtg 2195161 cgtccagctt gtaaataagc catctccccc gaactcacgc accttttgca agcctttgcc 2195221 aaggttcttg tcaaagcgtt tttcatcaca cacttcagcc acaagattgt ggccggacac 2195281 aaaaacactg gatactcccg gaaaatcaaa acggaaaatc ggtcccaatt catcagctat 2195341 ccgccataag gattgagaaa gctgttcttt ttccagatgc ggaagatttt ttaaaggtcc 2195401 gtatgttttg ggctgaggta ttgcgcttgc ctgtttcatt aacatctccc tttcctattt 2195461 ttgtgatgaa tgaagcttaa tggcgtccca gcagcattgt tccaattcag taattaaatc 2195521 agtgtccatc tctatatcac ctgtttgaac gagctgatat atcttgagaa acgcccctaa 2195581 tacaatcgca attaacacat tagagggcag gctgcgaatc acgccttccg cttttccctt 2195641 attaaaatag tcatcaagca tttgagtcag attttctatc atttttttgc ttgtatgatt 2195701 taagtaatga gcgtcttttt tggtttcaag aaaaaaaagc gcatagtcgc tctctttcgt 2195761 aaactgaacg agacagcaaa atacgtggtg aaagccttct ctgacaggca attctgaaac 2195821 gtcttgcttc agtttttccg taaatcgctg gatgctttct tgaaacagta cgttaacgag 2195881 tgtttctttg ctgtcaaaat aacgatagat cgttcctgtc cctacatgag cacgttcagc 2195941 tatcatagga atagtggtag cgtcaaaacc cctttccgta aaaagtgaga ctgacgcttt 2196001 cataatcatg tcgtatttac tgctggatgc ggatatcatg taatctgaca acctccgatt 2196061 cgtttacgga atgaatattc attccttttg ttcacaaaga atgtctgccc tgtctgatat 2196121 cacctctttg ttctttcttc tgttataagt ttatatgaaa aaaacttttt ttaatataaa 2196181 gtatatgcaa aaaataaaaa attaagaaaa tatacccaaa tcctaatacg aggatcttgg 2196241 atatatttcc cgagaaattt tttatttaac agccacaata catagacagg aagcacgcct 2196301 gataacagaa agatccctga aatgctggtc tttcagcagt tgaatatacg ttttctcttt 2196361 ttcaccggta tttgtgtcaa tactgatata aaaccggccg tcaatttgaa gcaccctgta 2196421 aatttctctt aatgcaagcc taatatcggt gcagctttga accgtatgta aagaaaagac 2196481 tttattaaag gtacggtcat caaagggaat gtcctctgga tagccatgaa aaacctcccc 2196541 gttccccatg ttctttcgat tcgcacgtga tatctgtctt acctttcgtt ttgaaggatc 2196601 aatgcttttt aggctaccct tttttagttt cttggttatg cttttaaaga cagtgccgtt 2196661 tccaattcca atttctaaaa ttctgtcatt ttcttgtata tctatagagt caatcatcat 2196721 atgctcaatt gttttggtta gcttatattt ccgagaaaat aatttccaaa aatccgatcg 2196781 tttatagagt ctattttcta gcattttaaa cacctgcttt tggtttccta tgtttattta 2196841 ttatcttaaa aaaataaaca tcatcttcat ttctaaaagt gaaggaaggt accaactaga 2196901 cggcaatgta ttgaaaaatg tttcaataga actaaacttt ttcatttttt tccgaaaaaa 2196961 aagcagaaaa cataatgttt tctgccctct ttctaatgcc aatgataagg gaatacatac 2197021 agcctttgct gctgcattgc catcagcctc tgctgtcgga atggatttcc ataaccatgt 2197081 ttgaaggaat gcggcatgga cgcataacca tggccaatcg acggcagtct tttttgataa 2197141 tcgttcatca tgccatcacc tgcctcacaa taacgttgat ttactatatg caggcgcgca 2197201 ttttcttgac agctatttcg ctaaacttgg tccttctcca ttgtataatg catcaatagt 2197261 tccattctaa gcatatgcca ttcccccttc agtttttttc gttgctttta gcgccagttt 2197321 gttaaataaa gatgctttaa ctgagactct ttcatttcat cataaatttg ttcaatctgc 2197381 tgttctcgtt cgaattcttc caggctttta aaccgttttt taatcgttaa cgttaaaaag 2197441 aataggttaa tcgtcatatc gctcaccccc tttcaaagtc cgcatcaagc gaaataaccc 2197501 gcggcacaac ccttctgccg cgggcaaata aaaaccgcag acaaaagaag acaccaatgc 2197561 ctctactgcc tgcggggagt tgcgtatgtc cgactattcc gaatttaatg cgtgcgataa 2197621 gcatcggtta aggaaggaca cgaactcttc cacaggctga ataaaccatg aacttttaca 2197681 tgtgtatcac gtacaggttg acgtcgttgt ctcattgtca ttttggttca gcctcctttg 2197741 cttttttctt actttgtaag tatatccacc aaattccatt ttgtaaacat ctttttctaa 2197801 aaatggacgg aaattgtgca aatcatcgaa tggatttgcc cgttggtcat gacacctgct 2197861 tcatttcttt tctggagcgg tctttcttat gatatgcaat aaaataaatg agaccgacaa 2197921 atacagctcc gccgatgaca ttaccgataa aagccggaat gatgtttccg atgaactgcc 2197981 cccacgtgaa tgagcctgca aaaatggcag caggaatcac aaacatgttg gcgacaacgt 2198041 gctgaaatcc gatagccaca aaagccatga ttgggaacca gatgccaagg atttttcctg 2198101 ctgcgtcttg ggcgccgaaa gaaagccaca ctgcaagaca tacaagccag ttacagccga 2198161 tggcggaaat gagaaccttg ccaaagctca tatcaagctt tccttgggca acggcaatcg 2198221 ttttttctaa ataaggacct gtttcagtca atccaaccaa atgcccgaaa aagtaagcaa 2198281 caaacaatgc gccgattaag ttcataattg tgacgattcc ccagttaatc gctaactctt 2198341 ttactgatat ttttctcgaa aataacgcca tcgcaactga catcatattg cctgtgatca 2198401 gttcagcgcc agcgagaacg acaaggatca ggccgactgg aaatactgct gcaccaatca 2198461 aactggacag gctcccccat tctttcggaa gatcgccaat taccctgata tcaagcaaat 2198521 acccaagcgc gataaatgca ccgcctaaaa accccagcac aagcagtgac ggcagcggga 2198581 gctttatttt tttcatccct gcttcaattg ctgcttccgc tatttcatcc ggttttcgaa 2198641 aagccataat aaaacgcctc cattacttct tcttttctca cagttatgca agaaaggcaa 2198701 taaaaaaggc agcactcaaa taacctgtgt caaaccaggc gtttgaatgc tgcctaactt 2198761 gtatgcatac ccatacaaca atatcaagca gtatataaga tattgaaaga gaatatatac 2198821 agttcgtgca tacattccat tgctttagcc ttctataact gtagcaacat catatcaaat 2198881 gtgacaaatt tgtgtcaatg acaaatatac tagctttgca gagcttcttt ttgctcatct 2198941 atttttcggt caaaaacaaa tacagataca gcgatgtttt cctcaatttt aatatcagaa 2199001 aacaaatgga ctagcttagc tcccataagt tcctccattc cttccggtgt ttgtttggaa 2199061 taaaggtctt gaattaggct tgtccgggcc gcatgtacca tctctcttcc ttcaggcgtg 2199121 cgggcaataa actgctcgct tgcactcaga tttccgtata gtgttgaaac tgccatgttt 2199181 tctacaaata cagtatgaat tctctcaggc ccttttccga acaattcttt gcgaagtttt 2199241 cgaataatat cattgaattc atgaattttt ttagacatgc tgattacccc ttccgatatt 2199301 gccttataaa ggcttttccc ggttcccctc aggacatttc acttggttaa aattttcctg 2199361 ccatattgta ttataataaa tatcacatta taataaaagc agtgttgatg gatttgtaat 2199421 aggatcttgt tatgagtcta tcgttttata aaaatcaagg attggtctgt tagtaagact 2199481 tgctagtgaa ctattccgcc atgtgtgttt acaccttctt agaattaagg gcaggtgtat 2199541 ctatacatgg ctttttttga cttcttgaaa gaaagatgga ggggaatatg aatatgatgg 2199601 acgttaagtc gatcagtgtc cgtgtagacg gaacagaaat tcaagcacga gcaggggcca 2199661 caattttaga tattttaaat gaaaacggaa ttgagtaccc gcagatttgc cacgtaccag 2199721 aggttgaccc gattcaaact tgtgatactt gcatagtaga ggcaaacggc aagctggttc 2199781 gttcatgcgc gacggttgca gaaaacggga tgtctattga tctttcagga aatcgagtga 2199841 aagaagcgca aaccgaagcg atggaccgcc ttcttgaaaa tcatttgctg tattgtacag 2199901 tttgcgataa caacaatgga aactgtacgc tgcataatac agcggaaatg atggggatcg 2199961 agcatcaaaa atacccatac acgccaaaag aagatccttc ttgcgcggtt gatatgtctc 2200021 atccttttta ccgctatgat ccaaaccaat gtattgcctg cggccagtgt gttgaggtct 2200081 gtcaaaacct tcaggtaaat gaaacactct caatcgactg ggaacgcgaa cgccctcgcg 2200141 tcatttggga tgagggagtt ccgatcaatg aatcttcctg tgtcagctgc ggtcagtgtg 2200201 taacagtatg tccatgtaat gcactgatgg aaaaatcaat gctcgggcag gctggtttta 2200261 tgacaggcat taaagaggac gtcatggaac cgatgattga tctcgtgaaa aatgttgaac 2200321 cggggtatgg cagcattttt gccatttctg aagtcgaagc ggcaatgcgt gaaacgagaa 2200381 cgaaaaaaac gaaaactgta tgtacgttct gcggtgtcgg atgttcattt gaagtatgga 2200441 caaaaggacg ggatatttta aagatccagc ctgtttctga tgctccggtt aacgcaattt 2200501 ccacatgtgt caaagggaaa ttcggctggg attttgtcaa ttcaaaagag cggatcacaa 2200561 agcctttaat ccgtaaaaac ggagcctttg tggaatcttc ttgggaagaa gccctcgatc 2200621 ttgtcgcaag cagattagga tcaattaaag agcagtacgg taaaggctct gtagggttta 2200681 tttcttcttc taaaattacg aatgaagaaa actacgtcat tcaaaaacta gcgcgtcagg 2200741 tatttgaaac aaacaacgtc gataactgct cacgctactg ccagtctcct gctacagacg 2200801 gattgttccg cactgtcggc atgggcggtg acgccggcac gattaaagat attgccaaag 2200861 caggcctggt catcattgtc ggtgccaatc cggcggaagg acacccagtg ctcgcaacac 2200921 gcgtcaaacg ggcacacaag ctccacggtc aaaaactgat tgttgctgac ctgcgtaaaa 2200981 atgagatggc tgagcgatct gatctgttca tcagccctaa acaaggcaca gaccaagttt 2201041 ggctgatggc tgttacgaaa tatatgatcg accaaggctg gcacgatcag gcgtttattg 2201101 atgagaacgt caattacttt gaagattata aagaaaccct taaaacgtat acgcttgatt 2201161 atgcagaacg catcacaggc ctttcaaaag aaaacatcat tcaaattgct gaaatgattc 2201221 gtgatgctga cggcacttgt gtcctttggg gaatgggtgt cacacaaaat acaggcggtt 2201281 ctgatacatc agcagccatt tcaaacctgc ttctcgctac gggcaactat cgccgtccag 2201341 gtgccggcgc ttatcctctg cgcggacaca ataacgtgca aggcgcatgt gatatgggaa 2201401 cattgcctgg ctggctgccg ggatatcagc atattacaga tgacaaagca cgcgctaaat 2201461 ttgaagaggc atatggtgtc gagattgatg gaaagcctgg tttagataat attcaaatgc 2201521 ttcatgccat tgaagaagga aaaatgaaag ctatgtatct tgtcggtgag gatatggcac 2201581 tggtcgattc aaacgcgaac catgtgcatg atattttatc aagccttgat ttcttcgtgg 2201641 tacaggacat cttcctgtca agaacagctc aatatgctga tgtcgtcttg ccggccactc 2201701 cttcacttga aaaagacgga acatttacca acacagaacg ccgtgtccag cgattgtatc 2201761 aggcgcttcc gacgcttggt gacgcaaaac cggactggtg gattattcaa gaggtggcaa 2201821 accgtttagg agcgaattgg aattacagcc atccaagtga cattttctct gaaatggcga 2201881 gtctttctcc tctgtttgcc aaagcaagct atgaggtgct tgaaggctgg aacagcttcc 2201941 tatggggcag cttcacaggt gaaagcacac cgcttctgta tgaagacgga tttaatttcc 2202001 ctgacaaaaa agcccgcttt gccctttctg attggaccga gccagcggca tttccggagg 2202061 aatatgacct tcatatcaat aacggccgga tgctggagca tttccacgaa ggaaacatga 2202121 caaataaatc gaaaggcatc caagcgaaag tgccgaatgt attcgttgag atctcacctg 2202181 agcttgcaca agagcgaggt gtttgtgacg gttcgcttgt acggctcgtt tctccgttcg 2202241 gagcagtcaa attgaacgcg ctgatcacag accgggtacg gaaaaatgaa ctctatttgc 2202301 caatgaactc gacagacaag gagtcagcga ttaacttctt gacgggccct gcagctgata 2202361 aacggacgaa cacgcctgct tataaacaga caaaggtccg catggaagtg cttggcggct 2202421 gtgaaacagc gccgcttcca aaaacaaatc cgcgcaacaa aaaacggcat ccgcaaaacg 2202481 gagtcgaagc agaaagaaaa tggaaccgcc ctggctatgt acatctgact gattaaacga 2202541 taggaggaaa acgaatggcc actccgatta cgacgatcaa aaaagaaaca aaaacagctg 2202601 agcaaattaa gcttgaaaaa atagaagaac tgaaagagct gctggcggaa aatgaggacg 2202661 ccgtctctaa aacgatgacg ttaatgaatg aactcaatga tcttggaatt tttgatgcgg 2202721 caacaagcat gctcagagcg aaggaagaca ttgccaagat tgcgcttggc caagtttccc 2202781 gcgagcctgt caccaacctc atcaacacga tgatggccgc cggaggcgca ttgacaaaag 2202841 ccgatcctga gtttacagca aagcttttag aaagcgtaat ggctgggact gaacaggcac 2202901 aaagcttttt aaaagaagac aagaaagtcg ggattctcga cctgttaaaa gcaatgaacg 2202961 atcctgacat caacagagcc gtcgggttcg gccttcagtt tttaaaaggc atgggaaaag 2203021 aacttcgaga acaataacag aaaaacagcc atctctgatg atggctgttt ttttattcgt 2203081 cggcttcttc cagacgcttc ttgtaaataa gtgaacggtc agcgcaaaag aaggcaccgg 2203141 ctaaaaatac gcaatccgct aaaaacatcg tcgatttctg gcctaatgtt aagccttgat 2203201 cagggagaac tgcgcctata tataaaaaag tgctgactgc aagcaatgta aaagcaaaat 2203261 gcttgtagtc ttcttttaaa gatttcattc tatttttgtt caaaagaatc acctgccaga 2203321 ttcatagtat acgactatta taatataatc cggcggctta cagagaaagt aattctatcc 2203381 atttgttata tattttcaag cgcttggccg atatcttcca acaagtcttc cgcatcttca 2203441 attcctacag aaattctgat caagccgtcc gtaatgccga gctcaagccg gcgttctctc 2203501 ggaatagagg catgtgtcat tcttgcagga acagaaatta agctttcaac cgcccccagg 2203561 ctttcagcaa tggtaaacag tttcagattt cctaaaaacg catcaacccg ttcttcactg 2203621 ccaatatcaa aggagatcat gccgccgaag cccgctcctt gcgtttttgc aagctcatgt 2203681 ccgggatgat ttgaagaacc agggtaatat aacgtttgga cagcagggtg attctcaaga 2203741 aagcttgcga ttttccgcgc attttgatcg atcgcttcca ttctgagtcc caacgttttg 2203801 attcctctca ttaacagcca ggaatcttga gggccgagca cgccgcctgt ggagttttgc 2203861 acaaaatgca gctcttctcc aagctctttc gaagctgtca caactaaacc tccgacgaca 2203921 tcactgtgtc cgccaagata ttttgtcgca ctgtgcagta cgatatcagc gcctaaagta 2203981 agcggctgtt gaaaataagg agtattaaag gtattgtcta cgataagcag aacacccgct 2204041 ttttttgcga tatcagccat gagcgtcagg tcggtgattt tgagcaacgg gtttgtcggt 2204101 gtttcaatat aaattgcttt tgtattaggg cgaatcgctt tttcaacttc ttccctgctg 2204161 ctcgtatcaa caaatgttga ttcaatgcca agacggttaa gcacctttgt catcacgcga 2204221 tatgttccgc cgtacacatc atcagtcaac acgacatgat ctccgctgtt aaacagcatc 2204281 ataaccgctg taatggcagc cattcctgag ctgaacgcat agcctgcttc cccgctttcc 2204341 agttctgtca caagtgcttc gagagcggtt cgagtcggat tggccgttct tgaatactcg 2204401 tagcctgtat gctgccctgc tttcggctgc ttgtacgtgc ttacttgata aatcggcacg 2204461 gaaactgcgc ctgttttctc atcacctgtg attccgccat gtatcatcaa tgtttttttc 2204521 ttcatatcag atgcctcctt cgtatatttg tttgctgata tatcgatcgc tgctgtcagg 2204581 aaatactgtg acaatgttag ttccagcgga tgcttttttc gcttcctcca atgccgcata 2204641 aagcgctgca cctgaagagc ttccgatcag caggccttct ttttctgccg cttctttcac 2204701 aagtctaaac gcattctcat ctgttacggt gtagatctcg tcaaaatggc tcttatccat 2204761 ataatcgggg ataaactcca tgccgatgcc ctctgtttta tgagcgtggg gctctcctcc 2204821 gtttaaaatc gagcccaccg gttcaacaat caccgttttg actgctggat ttttttcttt 2204881 taagaaggaa gctgtccctg cgaatgtgcc tcctgatcct gcccctgcga caaatgtatg 2204941 aatattcccg tcaagcgctt cccacatttc aggtccaagc gtcttatagt aagtcgatgg 2205001 atttactcgg tttttaaatt gcaaaacgca ataagaattt tcaatttcag tctccagctg 2205061 aatggctttt tgaatggctc cctgcattcc gtcttgacgc ggtgtatgaa tgattgatgc 2205121 gccaagcgct tgcataattt gctgtttctc tctgctgaaa tgttcaggga cacagaaaat 2205181 cgctttcagc ccatattttc tggcacttaa cgcaaggccg atccctgtat tgcctgccgt 2205241 agcttctata atcactccgc cgggtttcac tttgcctgaa tcgagcgcgt cacgaatcag 2205301 catatctccc agtctgtctt tgatgcttcc ccctggattc atcatttcaa gcttggcata 2205361 caccgcgact ccttctggaa catcaaagtt cttcaagcgg agaagcggtg tattcccaat 2205421 cagctcggta atgtccgtaa tcactgtcat atatgtcctc ctccttaata gaggttgttt 2205481 ttagagaaaa acggaggaga acgttctccc cgttttaatg aattcgtttg atcaccttta 2205541 acacaagctc tgttgaatga acagccgcct gctctaaaaa ttggtcaaat gaaacatgtg 2205601 attctttgcc tgcgatatct gataacgctc tgatgacgac aaacggcgtt ttaaattgat 2205661 ggcatacttg agccactgcc gcagcctcca tttcaaccgc gtacagatca gaaaatctcg 2205721 cacgcacctc ttcaacccgc ttcggatcgt tcatgaaaga atcgcctgtt gcaatcgttc 2205781 cttttgcaac ctgaatgccg tcgagttcag ataccgcttc ttcagtgatg ctgatcagct 2205841 tttcatccgc cgcataagca gccggaagac ccggcacttg gccgtattca tagtcaaaag 2205901 ccgttacgtc tacatcatgg tggcgaacgt cagtggaaat gacgacatcc cctacattca 2205961 atgtatgatg aaatccgccg gctgagcctg tgttaatgac ataatcaggc ttgtaacggt 2206021 caagcagaag cgtcgtgctg atagcagcat ttacttttcc aattcctgat tttaaaagaa 2206081 tcacttcagt tccttcatat tcgcctgttg taaattcaca gtgtgcgatc gtttctgttt 2206141 ttgcattttc aagtttgttt cttaagatgg taacttcctc ttccattgct ccgatgactg 2206201 ctagtctcat ctattcacat tcccttcact ttaccgtttg atcgcctcca ttatccacac 2206261 gaagtcgttt tgctgagtga atcggactgc aaaaccttca gctgtaaaca tttctttcaa 2206321 cgcatccaat gtaggataat gctctgtctc taaatcattt gcaagctgat aaaagccttg 2206381 agaacgggct ttatcgatag cctgttgata cgcttgcgca ttttcaaaga cggtatcggc 2206441 aaacactatt ttatcatgca agtgaaggta tttgccatat tgctttatgg cagcccgctt 2206501 ttcttcgtca gtcaaatgat gaaaagcata tgaactgaca atcgtatcag cctgaaatgg 2206561 cggctcaggg aatgtcagga agtctccatc aacgatttcc gtcctgcctg agagcttgtc 2206621 agaagccagt ttacgcattg ctggagaagg ttcgattcca aatacagttt tgcctgcatc 2206681 gagcagctta gctgtcaaat tcccggtccc cgggccaaat tctaacacat gcgttccaga 2206741 ttttctgacg atggcatcaa ggatatgatc gtagcctctg aacgcttctt tatactgaat 2206801 atctaaacct tgtactgttt gatcataagt tgctgcccaa tcttcaaaga gagggataaa 2206861 ttcacggccc atatttgtca cactccatat ttaataattc ctataagtat actatggatt 2206921 aatgatggaa cagttcctat aataccacat attctgaaaa gcaggtacta aaacactttg 2206981 tgtattttat gccatctcat attgcgcatt gaccgcaaaa aagcttatac ttcatatgac 2207041 ttgtgaaagc tggagggtca agacatgaat tttcaattag atctgattaa agacaaagtg 2207101 gaattttttg aagcggcttc attgcaggag cttgaaaaga aaatcaatac acaaattgaa 2207161 aacaataaag ccatcatgct ccgggtgaaa tctgtttcac accaaactct tgtggcagaa 2207221 ggaagaatat tgtacagcgc ggtggttcat ttctcagctg aagcctaaaa caaaagcagc 2207281 cggttttaac ccggctgctt ttgtttattt tagcttttct acttttgtcg gcttccagcc 2207341 tttttcatcg acccatgtaa tcgtgacttg atatttattc ccagtcgcct tgtccaaaat 2207401 cttgcctttg gcatcctgag ggctgccgtt atttccaagc cagagcaccg tcatgttatc 2207461 tgttgagaca ccagttgcgt acgaaatggc tttcagcatc tcagcccagt cttgtgagct 2207521 tgaatcataa gtagcggcat gctcgccagt ctgctcagtt ccgactgctt tccagtcagg 2207581 attttcatac gttttttcca catcgctcga tgagccgcct tctgttactt ttgcatcttt 2207641 aagcccgtca ccggctgaat ctgagcttga atctgaatca gagtcatctt ttttagaaga 2207701 agaatcatct tttttggaat cagagtcaga agacttctca gaatcctttt cgctgtcaga 2207761 tgtatctttc ttgctgtctt ttatatcctc atccgatttc ttttccgtct ttcctgaagc 2207821 cggagattcc tgtttttgcg ccgtttcaga atccttgctg acatctttgc tagaaggact 2207881 gttaatgaag agattcgctg ctactacgac aattagtatg gatacgattg cgattaaaat 2207941 gttaagcact aaattggctt ttctgcgttt atcacgattt tcataacgag attgattatt 2208001 gctcaataat tctgcactcc tttatccctc ttggctcagc atatatttta acatgtgctg 2208061 agaagttgtt ctatttctga ttgatttcaa tttcgtgtac ttttttaaca atatcataaa 2208121 acaccgaatt tgtcagagcc ttatctcccg gtgtatccat gtgtaaaaca actagagcgt 2208181 atttcggctt atccgcggga aaatatccgg caaaccattt ttcgtagagc gtttccttct 2208241 cttttgaaag cttgcctgtc tgggctgtgc ccgacttccc tgctacagta tacggaagat 2208301 cttgaaacct tctgcccgtt ccggaaggag attctactac ccgccgcagt attttttgaa 2208361 gctgctgtga cgtatatttg tctatcgttt cccctttgag cttctgatct ttaaacgtaa 2208421 cgagcgttgt gccgttctta tactcaattt gttcggcaat tttcacctgc cgtttttctc 2208481 cgccgcgggc gattgtcgcc atcatattgg ctacctccag cggcgttacc tttacatttt 2208541 tctgcccgat tgctgtttgc gcaatggctt ttttgactga tttgtctttt tcatcccccc 2208601 aaatcacgcc gcttttttcg ttatacagct ggcggaaatc ggtttcgtgg tacagttttc 2208661 cctcccagcc tgcccgatca gtgagagcca gcttctcgga catatcttca ataaccgagc 2208721 tgtctttttt cattaattgt tctgcaagac tcgtaaatgt gtaattacag ctttgggcaa 2208781 aactttcatc aaaagacaag gtgcctttgt cgtcccccgg ttccccgtac aggtttaaat 2208841 tgcaattaaa ggtttgacta ggcttcacca tattattttc gattgcagct gcggcaatga 2208901 ctgttttaaa aactgatccg ggatagattg gcgtcagcat ataattttga agtgtgtttt 2208961 gccgggacac gtctgcatct ggtttgctta caattcccag aacactgcta ttttcgatgt 2209021 ccagcagcac agctcctccc tttttcagcc cctgttcatc caatacctcc tccatcgctt 2209081 tttgaatgct ttgatcgatc gttgttttga tctggagcgg ataaaatgta ttggcttcag 2209141 ctgtatattt gacgtccatg ccaaacaaag ggtttccttt tccgtccaca tgatataaaa 2209201 gctttgtgtc ttgttccgga agcaaaaact cgtcaaatgt ccgttctaaa ccggttgttc 2209261 cgatttctgt tgtaatcgga aggctctcct tgtcaggata tttcttgcga agcagcgccg 2209321 gatcttggtt cgtgctccct atcgtatgtg aagcaaggct gggcttgtct tcattctcca 2209381 tatatacgcc gtaaatgccg ggatatttca aagaattgat ttttgtgata gattgttttg 2209441 aaagtgtttt gattttcttt tgctgcaaaa tgaccggttt ttttgcctga cctagtgtct 2209501 ggcgcaaatc atcttcagac atgccgagga tgtccgcaac ttttttgatc ggccaatcct 2209561 gcgtcagcag aaaagggaac aaaacaaccg caggctcgct ttgtcctgtc agcgcccgcc 2209621 cgtttcgatc taaaaaagag cctcttccat ctgaaatgag cacttcctcc gtccgctgtt 2209681 tcacactttc ttgaatcaaa ttaattttct ttttagaaaa tgattctgtg aaaaacagct 2209741 ggatttctgc aagtctcagc agaagcagaa aaaatacaat caaaaaagcg atgactgcca 2209801 gcttcattcg tttcgatatc ttcataaaaa aacacctcac ccacattgtg gacgaggtgt 2209861 ttcgctgcta aacagatatt atgaaatttt cacaattttc acgagcattt ctccgcccgg 2209921 tgtttgtact gtgacttctt catctacttt tttgcccaag aggctttttg cgatcggtga 2209981 atcgtttgag attttccctt caaacgggtc agcttccgcg cttccgacga tcgtatatga 2210041 ttcttcatca ccgtcaggca gttcgacgaa agtgacggtt ttacccaaac cgacaacgtt 2210101 agagccgccg tcatcttcaa tgattttcgc attgcgaatc atattttcaa gagtcgtcac 2210161 gcggccctct acaaatgcct gctcttcttt cgctgaatcg tattcagagt tctcggaaag 2210221 gtctccgaag cttctcgcaa ttttgattcg ctctactact tcttttcgtt taaccgtttt 2210281 caaatattct aattcttgtt caagtttttg ttttccttct gcagtcatag gaaaaacttt 2210341 ctcttgtgcc atgtcccttc actccttctg gttgtccctc aacatcttcg attatgtatg 2210401 agagcataaa ctaaaaaata caagaatgag aacacagggc agtcctcgtt cttctctccc 2210461 atataggtac tgtttatctt aaactgaatc gtgtcgttct gcaaatattt cgcgtttata 2210521 aacagggaaa gaagggaatt cgcacattcc cttcctgcct atacataata tggtcagagt 2210581 tatttatgtc tatgctatgg tattacaaaa tcgcgttttg ttcaagaatg gtttgaattt 2210641 ttgtgaccat cagatcaatt gcgacgtgat tctgaccgcc ttccgggata ataatatcag 2210701 cgtatcgttt cgtcggctcg acgaattggt tatgcatcgg acggaccact gacacatatt 2210761 gttcaatgac agaatcaata gagcgtccgc gctcattaat atctctcata atccgtctga 2210821 tgatacgcaa gtcagcgtcc gtatcaacat aaagcttgat atccatcaga tcacgaagcc 2210881 ttttgtcttc aagaacaaga atgccttcaa ggataataac atcctttggc tctacgtgaa 2210941 ccgtttcttc tgaacgtgtg tgaagcttat agtcataaat cggcttttca atcgggcggt 2211001 aattcaatag atcttgaata tgctcgatta aatagtcatt atcaaacgca agcggatgat 2211061 catagtttgt gttcagcctt tcttcaaacg gaagatggct ttggtcttta taataaaggt 2211121 cctgctggat cattaaaatt gagtgtcctt taaactgttc ataaatggac cgtgtgacac 2211181 tcgtttttcc tgaaccggaa cctcctgcga ttccaatgac tactggattc ttacccatgg 2211241 gctgttactt cccctttctc atcatgttgc tcggataaat ctttttgtct agtttgaatt 2211301 tgacaatttg caggggatgg cgggcagcat ctagctcatt tccgtcttcg tcccaaatgg 2211361 tttcaatcgt atgtgtaaag ttttcgattt ctggaccgaa aaattccact tcgtcgcctt 2211421 ttttgaagaa attgcgctgc tgaagcgtga ccatttgtgt atcttcatca taattcagca 2211481 ctaagccgac aaaatcatat gtcgttttct tggcgtgttc gccgaacatt tgctcttcat 2211541 agcctggcgt tccttcaaag aaagctgtcg cagtgtccct gttggcgcac ttatcaagct 2211601 cttcaagcca ttctttttga atcacaaagt tttctggatc agcgcaataa gcatcgatta 2211661 ctttgcggta tacgctgaca acagttgcta catagtgaat ggatttcatg cggccttcaa 2211721 tctttaagct gtcgatcccc atttcaatca tttttggaat ggattcaatc agcttcaaat 2211781 ctttcgggct catcgcaaat ggtgcatctt cttcaccata caaagcaacg gcgttggcac 2211841 cgtctgtttg gtagagatca taatcccagc ggcatgactg gcagcagcct ccgcggttgg 2211901 aatcccgcgc tgtcatgtga ttgctcagca cgcagcggcc ggaatatgca atacacattg 2211961 cgccatgaat gaaggattcg atttcgatat ctaccttttc tttcatttct ctgatttcaa 2212021 gagcgctagt ttcacgtgcc agcacgacgc ggtcgagacc ttcttccttc cagaactgga 2212081 cagccttcca gtttgaaaga gactgctgtg tgctcaagtg aacctcaaca ttcggcgcca 2212141 ctctgcggca tgtttcaata ataagcggat ctgccacaat aataccggca acgttggcgt 2212201 ctccaagcgc ttttaaatag tcttcaagcc cgtccatgtt ttcattatga gcgaaaatat 2212261 tcgttgttac gtagatcttc gcgccatatt tctttgcgaa ttcaacgcct tctgcaattt 2212321 cttcgatcgt aaagttatcg gcattcgagc gaagcccgta ttcctgtccc ccgataaaga 2212381 ccgcgtccgc tccgtaatga acagcgattt tcagcttttc aagattaccc gcaggtgcga 2212441 gaagctccgg ctttttcgta atcacacgct ttccattaac gattgtggat attttatcat 2212501 ttacggcagt catagcttaa cctccttttg attaataaac cgtttccttg aagaagaatc 2212561 cggtatcaat ttttctgttt actggctgga tgctttcaat gcgttcgatc cagtcttctt 2212621 ttttcgcttc gtattcgtca cggttttcca cgcacaaatc aattgcttct ctgtacattt 2212681 tggtgacttc tattaggtat tcaggcattt tcaaaacacc atcgattttg aaagaatcaa 2212741 ttccggcatc tatcaattcc tcgagctcat caatgatgca cacatcgttc gggctcatga 2212801 tgtgagtgcc gttttcatct tcgaaaatcg gatatttatt atcgcgttct ttatcgtgta 2212861 aaaacatgcc tgattctttt ttctttcttt caatgtccat gactttgccc tgatattcaa 2212921 aatagtttcc aatcaaagaa cgcttcgatt ggaacatgca cgtcattcca tgcacctgga 2212981 tttcaatttc gacttcagca ttttctttaa tctcaacaat gctgtccatg tttaattctc 2213041 tggcaagcac agaacgcgcc gcacccttgc gtccccagta gttgcatgta taatagttgg 2213101 tgcctgtcgt ttctgtgctc caatgaagct tcagatcagg cgcagattca cgggcagcca 2213161 tcagcacggc aggatcgccg aataccgctg catcgacacc ggcttctgct aagaaagcca 2213221 gatattcgcc aagctcaccc actttatcat tatggaaaat tgcatttaca gcaacgtata 2213281 cttttgcccc ttctttgtga gcaatctcta cggcttttgt tacatcttca cgagaaaatt 2213341 ctccggctaa tctcaagccg tatctctgtt ccccaactaa aaacgcagtt gccccagcct 2213401 gtatgagcgg caaaatgtcc gctgtactcg tcggcgtcac taagagctct ggttttttca 2213461 tgacgttcac ctcttctttt tactaatcgc aagtccgtcc ccgacaggaa taatcgcagt 2213521 ttgataatcc ggatgattca tcagccaatg attatattca tcaattttgg ctacaagcct 2213581 gcgccttctc ttcggttcta ttttgctgta atcctctgcc accagacctt taaacagcac 2213641 gttgtctgtt ataatcaccc cgtccggtga aagcatcggt tcatataaat gaaaaaagtt 2213701 ttgatactga ccttttgcag cgtcaataaa aatgacatcg taaggcgcgg ttacatgaac 2213761 ggcgtcggct aattcaagcg catctccgta aaaaacatga atccggtcat caagctgaaa 2213821 ttccttgata ttgtttaccg cttcttcatg ccgtttctca ttgcgttcaa ttgtatatat 2213881 ttcagcagac ggcagttcca gagccattcg aatggctgaa taaccaatgg ccgttccgat 2213941 ttctagtatt tttttcggct gtttcacaga caaaatttga agcagcacct ccatgcccgc 2214001 tttttccata atcgggacat gatgttcttc tgcatatgct tcaagtctct tcacgttatc 2214061 cggccgaggc tttaataatg cttctatata gtcatttatt tgttcatacc ggtcagtcac 2214121 tacaaacagc ctcccgttct aaaaaggagt gccccagtct tatgcgcagg acactctctg 2214181 aatacatcat gatacatcgg taaacaaccc gatatatttt atcataaaac cttgcggaaa 2214241 gcgaacaaaa ggagagcttt ttgctctcct tttatttctc attttttgag gaaatgtatt 2214301 tttcttttgc tttattatgc tcttttagcg tttttgtaaa tacgacctca ccatttgatt 2214361 tggccaagaa atacagatag tccgttttat ccggatgcag cgctgcttcc catgatgaca 2214421 tgccggcatt ggcaatcggc cctggcgtca gccctgtgtt tttatacgta ttgtatggtg 2214481 aatcgatttc cagatcctta taaagaaccc gatctttatg cttgcctgcc gcgtacagga 2214541 cggtcggatc tgtttggagc ggcattttct ttttcaggcg gttataaaag acgctcgcaa 2214601 ttttatggcg gtcggctttt tcagtcgctt cttcttctat caaagaagcc attgtcagca 2214661 gcttatgcac agaaactttg tttttcttca tttctgattt atatgtttcc acataagaat 2214721 ttgtctgctt aatcattgcc ttgataatgt cttcaagtga tgtgtccgga tcgttaaaag 2214781 ggtatgtagc cgggaatagg tacccttcaa gcgggtgctt aatgttttta ttgaaaacat 2214841 catttgtcac agtgtccggg aattctttct tcagctgatt gataaatgtt tcatcgtcca 2214901 gcttcgctat gacttgtttt ttagagtatt ttgtttcatc agcaatagca gccgcgattt 2214961 gggtcagctg tgctccctca gtcactgtga tttgaaaagc gtaacctgta gccccgcttg 2215021 tcagcttctg aataatggca tctaaatcca tacctttatt cagatggtag aatccggcct 2215081 gaaacccgga agcaccttta tatttcacat agtactgaaa cgccttctcg ctttttatga 2215141 catcattttt ctttaatatc gatgcgatgg ctgaaacaga cgaaccgctc ggaatgttaa 2215201 tattaactgt cgttttactg tctttttcaa caggttcaag caatgatttc ccatataaaa 2215261 atgccccgcc aatgatgaga aacagcacaa caatggaaga cagtatgatt ctttttttat 2215321 taaaaaacga ttttttttgc tgattgatat acattaggtc tcctcccatc agctcttata 2215381 ctacatgatt cattgtattt cggcaattta ttacaaaaag aggcctgcat aaagcagaaa 2215441 aaagccggag cagtatagct ccggctttgg tttggcgcga tgttttactc ttcgtcttcg 2215501 tccgctaaga atgtgtttag tgtttcttcg atcatatccc attcttcgtc agtttcaatc 2215561 gggaatagct caccgttttc accgtcttcg tttggcgtga agctggaagc aagaatttct 2215621 acttcttcgt catcttttga ttcgattgga tagtacaaga cataagattt gccaaactct 2215681 tcattttcaa atgtaaacag cacttcacaa agctgttcat ttccttgatc gtcaacaatt 2215741 gtaatatttt tttcgccgtg ttccattttc ttcacctctg gctttaattt aagctgtcaa 2215801 gatatccttg taaaatcata acagccgcca ttttatcaat gacttttttt cgtttttgcc 2215861 tgctgacgtc agctgcaatc agcatttttt cagccgccat tgtggtaaga cgctcgtccc 2215921 acagcacaac aggaacattg tacgttgttt caagcacttt cgcaaatgtt tggctggctt 2215981 cgcctctcgg gccgactgtt ccgttcatgt tcttaggaaa gccgagcacg attttatcta 2216041 tagtatagtc ctttatcagt tcagataaac gggataaacc ataatcgcct tctgcttcat 2216101 ttatctttat ggtctcaatg ccttgagcag tccagcccat ttcatcgctc agagctacac 2216161 cgagtgtttt ggttcctaaa tcgagtccta atattctcat tctttattta cgcctcttta 2216221 tgctgttcta aataagactt taccaattcc tcgattaatt cgtctctttc aagtttgcga 2216281 attaaattgc gagcgtcacg atgcctagga atataagcgg gatcacctga cagcaagtat 2216341 ccgacaatct ggttgattgg attgtagccc ttttcctgaa gcgcgtcata cactgtaatc 2216401 agcacctcat ttacgttagt ctcagcagaa tcatcggaga aattaaattt catcgtttta 2216461 tcaaacgagc tcaccgtttt gcacctcttt cccaaattcg caggcaaagt tcagcctggg 2216521 gtcctaatct taccatcatt ctacactaca tgggcgaatt ataaaacgga tttcacccaa 2216581 tcttctacag aagccaaagc ttcttctaat ttttccggct gtttaccgcc tgcctgcgcc 2216641 atgtccggac ggcctccgcc gcctccgccg caaacttccg cagcttgttt aaccagcttg 2216701 ccggcgtgaa gtcctttctc aatgaggtcc tttgtgactc cggcagagat attaacttta 2216761 tcgttttgta ccgcaccaag cacgatcacc gcagagccaa gctttgcttt gagttcatcg 2216821 accatagtgc ggagatgatt catgtctttt gcatttactt ttgccgcaag cacgtttacg 2216881 ccgtcaactt cttttacttt cgacaggatt gctcctgctt ccacgttgcc tagttttgca 2216941 agaagagatt cattttctct ttgtgcatcc ttcagttcag cctgcagagc cgcgacccgt 2217001 ttcggcactt ctttgatatt tgttttcagc tcgtcagcgg tctgcttcaa tacagaaatc 2217061 tggctgttca tttcgacgta agcgccttgt cccgttacag cttcaatccg tcttgtgcct 2217121 gctccgattc cggattcaga aacgatttta aacaagccga tttctgctgt atttctgacg 2217181 tggcagccgc cgcacagctc taagctgtaa tctccaactt gaacgacacg gacaatatcg 2217241 ccatattttt cgccgaacag tgccatcgca cccatttctt ttgcttcagc gatcggtttc 2217301 aaatcaatgc tgaccgggat gctcgcccag atcttttcgt ttacgattct ttcaatttgt 2217361 tcgagctctt cttttgtcac ttggccaaag tgcgagaagt caaaacgaag gcggttttcc 2217421 gttacaagag agcccgcctg attgacatga gttccaagaa catcttttag agcctgatgc 2217481 aataaatgcg ttgccgtgtg gtttttaatg acgccgcttc tcatatggtc ttcaacttca 2217541 gccgtaacat gcaggccttt ttgaacagta ccgctctcca caacaccttc atgcacatgc 2217601 tggccgttcg gcgctttttg aacatcttta attcttacaa ctgcctgctc gcttcggaga 2217661 tagcctttgt cgccgatttg gccgccgctt tctgcataga acggtgtttc atcaagaatg 2217721 atttgaacgc tttctccttc atgagcctct tcgattaatt ggccgtcctg aagaagcaca 2217781 atgatattgg catcagcttt ggtttgagag tagccgacaa atgtgctttc aactgtcacg 2217841 tcgcgcagtg cgccgccctg cacctgcatg ctgccgacat cctggcgggc gtttcttgcc 2217901 cgttcacgct gctggttcat ttcctcctca aagccctcat ggtcaaccgt catgttctcg 2217961 tcttctgcgt attcttcagt caattcaacc gggaatccat acgtatcata cagtttaaac 2218021 acatcagcac ctgagataac gctgctgccc ttgtcttttt cttttttgat catttctgac 2218081 aggatcgcaa gcccttcatt aagggtctca tggaagcgtt cttcctcggt tttaatgact 2218141 tttgcgatga aatccgcttt ctctttcact tcaggataga aatcagccat gatttctgcg 2218201 acaaccggca ctaaatcaaa catgaacgga cgatggatgt tgatcgtttt ggcataacgc 2218261 acggcacggc gtaataagcg tcttaataca tagccgcggc cttcatttga cggcagcgca 2218321 ccgtcactga cagcaaaggc aaccgttctg atatggtcag caatcacttt aaacgcagtg 2218381 tctttcacat tgtctttgcc atatgtttca ccagaaatcg attctgttgc tttaatgatc 2218441 ggaacaaaca aatcggtgtc aaagtttgtc ggaacattct ggatgacaga caccattctt 2218501 tcaagaccca tgcctgtatc aatatttttc tttggaagcg gtgtgtacgt gccgtcaggg 2218561 ttatggttga actctgagaa cacaaggttc catacttcca ggtaacggtc gttttccccg 2218621 cctgggtaaa gctccggatc ttctggatca ttaccgtatg cttcaccgcg gtcgtaaaag 2218681 atttccgtat tcggtccgct cggcccttca ccgatatccc agaagttccc ttccagacgg 2218741 ataattcttt cttcaggaat accgattttt ttcgcccaaa actcatatgc ctcttcatct 2218801 tcaggatgaa ccgtaacaga gagaagctct ttgtcgaagc caatccactt gtcgctcgtt 2218861 aaaaactccc aagcccatgt aatggcttct tctttgaaat aatcgccgat ggaaaagttt 2218921 ccgagcattt caaagaaagt gtgatggcgc gcagttttac ctacattttc tatatcgttt 2218981 gttctgatcg ctttttgagc gtttacgatt cttggatttt ccggcacgac acggccgtca 2219041 aaatattttt tcagcgtcgc aacaccgctg ttgatccaaa gcagtgaagg atcctcatga 2219101 ggcactaatg acgcgcttgg ctctaccgca tgtccttttt ctttaaagaa atccaaaaac 2219161 atttgacgca cttccgcaga agttaagtgt ttcattgtat ttcctcctct ataaaaatcg 2219221 aaattctctt cagtgacagc aaaaaagccc tccccctatg caaaccaacg tttacacagg 2219281 gacgagagct gtctcgcggt accaccctga ttacgggcat tcatgcgccc gtcaccttta 2219341 accctgtaac gcaggataag cggcagtgat taactgcact caggattagc ttcctccgat 2219401 cttctgataa agctcctttc agcttatgga gcttctctct ttaacagggc ttcggcgtac 2219461 tcagatccgt cactcgagat tcgtatgtat tctacgagaa attatagaca agcggcacgc 2219521 cgatgtcaat gctccgtcct catccgcaaa aaatggatca tcattacttt taaaacagcc 2219581 gtcgcaggaa cagccagaat catcccgacg atacccgcaa gctcccctcc ggcaaggagt 2219641 gcaagcatga taacgaccgg atgcatttta aggcttctgc cgacaatgaa cggactgagg 2219701 atatttcctt ccataaactg cagaataaac accgtaatca ccacaacaag aaccgccttg 2219761 actgagatcg tcatcgcaat taacaacgca ggaacagctc cgatgaaagg gccaaaatac 2219821 gggatgacat tcgttacccc agagataagg ccaagtatca gcggatacgg aagcccaaat 2219881 acccagaacg aaatgcctgc aatcacgcca agaatcaagc agaccaaaag ctggccgcgg 2219941 atataatcgc caagcgaatc atccacatcc cgcaaaaagg cgctgccccg ctttctccac 2220001 gacttcggag tcaagtacca tactgtcttt ttcattaact caatgtcctt caccatataa 2220061 aacacgagaa aagggattgt tgcagcaatt aagaagtaat caagcacatt gcggatcccg 2220121 ctgatcgcac cctcgatcgt tcccgcaaaa aacgcctccg tctggcggat cattttatct 2220181 atacggtgat gcataccatc aggccagtca tccgtatggt tatgcacatg aagaagaagc 2220241 ccgttatacg tttcggcaaa catgggtata ttttctgaca aatccgtcag ctgcacgatt 2220301 aaaacaggca cccctttata caacgcccag ccaatcccgc caaaaaaaag aacataaatg 2220361 accaagatgc tcaaagtcct aggcaatcct ttgccatgca gccattctgt gaccggaagc 2220421 aataaataag atataaaaat agaaatgatc aagggaataa agatcgtttt tatgacgagc 2220481 caaaagggtg accataacat atcaagcata aaaaagacat agactgttaa cagaaccagc 2220541 aaacaaatag ccacccacaa caaaagctgc accggttttt ggagcatctg ctttcacctc 2220601 acctatatct tttgaggttt acaaggaatt attctttatg tttctttagt cagtcagaag 2220661 tcatggacat tttttcactt ttaattttca gaaaagtttg atcatttact ttttggtcaa 2220721 attttctgat aggaggattg cgatgatcac atttcaaaat gtaaacaagc attacggaga 2220781 ttttcacgtg ttaaaacaaa ttaatcttca aatcgaaaaa ggtgaagtcg ttgttatcat 2220841 cggcccatcc ggttccggta aaagcacatt gctcagatgc atcaacagac ttgagtcgat 2220901 caatgaggga gtgcttacag taaacggcac cgccattaac gacagaaaaa ctgatatcaa 2220961 tcaagtgcgg caaaatatcg ggatggtgtt tcagcacttt catttatatc cgcataaaac 2221021 agtgctgcag aacatcatgc tggctccggt aaaagtgctt agacaatcac ctgaacaagc 2221081 aaaggaaacg gcgcggtact atcttgaaaa agtcggcatc ccagacaagg ctgacgccta 2221141 tccttcccag ctttccggcg ggcagcagca gcgtgttgcc atcgcaagag gactggcgat 2221201 gaagccggag gtcatgctgt ttgacgagcc gacatcagca cttgatcctg aaatgatcgg 2221261 tgaggtgcta gatgtcatga aaacactcgc caaagaaggc atgacaatgg ttgtcgtgac 2221321 acacgaaatg gggtttgcca aagaagttgc cgaccggatt gtcttcattg acgaaggaaa 2221381 aattttagaa gaagcagtgc cggctgaatt ttacgcgaac ccgaaggaag aacgggcccg 2221441 cttattctta agccgtattt taaatcatta aaacagaaat gggggagctt gtatgaaaaa 2221501 gattttttct ttagcattga tttctttatt cgctgtcatc ttgcttgccg cttgcggcag 2221561 caagggatca aacggagaag cctcaaagga gagcaaaaaa gatacgctag ccgccattaa 2221621 agacaatgac aaaattgtct tcggcgtaaa aacggacact cgactgttcg gtcttaaaaa 2221681 tccaagctca ggtgagattg agggttttga tattgatatt gctaaacaaa tcgctaaaga 2221741 cattttaggt gatgagaaaa aagctcaatt taaagaggtc acctcaaaaa caaggattcc 2221801 tatgctgcaa aacggggata tcgacgccat tgtcgccaca atgacgatca ctgaagaacg 2221861 aaaaaaggaa gttgactttt ctgatgtcta tttcgaggcc gggcaatcgc ttctcgtgaa 2221921 aaaaggcagc aaaatcaaga gtgtcgagaa tcttggcaaa ggctcaaaag ttcttgcagt 2221981 aaaaggctcc acctcctctc aaaacattcg tgaaaaggcg cctgaagcat ctgttttaga 2222041 atttgaaaac tacgcagaag cctttacagc ccttaaatcg gggcaaggcg atgccctcac 2222101 cacagataat gcaattttat atggaatggc tgatgaaaat aaaaattatc aattaacagg 2222161 aaagcctttt acagatgagc cttacgggat cgccgtgaaa aaagggcaat ctgctctcgc 2222221 gaaagaaatc aacgcttcac ttaaaaagat gaagtcggat ggcagatacg atgaaattta 2222281 taaaaaatgg atcaaagaag acccagctga ataacaacca tcccgggatg agcaggcgat 2222341 gctcatccca atttgataag gagtgaatag gcagatgaat gtgtcaattc ttttcgataa 2222401 cttcagcatg tatatggacg gtttttacca taccttgctc gcaagtgtta tcgcgctggc 2222461 cggcagtttt gtcctcggcg ttgctgtagc ggttatgaga ataacagtct ttaagccgct 2222521 gcaatggctc gggaccgcat atgtagaatt catccgcaac atccctcttc ttttaattac 2222581 ctttgttttc tatttcggac ttccaaacgc aggcctgagg cttgacggtt ttcaagcggg 2222641 aacggttgct ctcaccattt atacctctgc gtttatcgct gaagccatca gagcaggcat 2222701 ccagtctgtt tcaaaagggc agatggaagc ggcacgctcg tcaggcttta cctacagcca 2222761 agccatgctc catatcattt tgccgcaggc aatcaaaatc gtcattccgc ctttaggcaa 2222821 tcaattttta aacttagtca aaaactcttc gattcttggg gttgtggccg gattggatct 2222881 tatgtaccaa gccgatttag tttcgtcgag cacactcgtt gtatttgatg tttatatttt 2222941 tgtggcgctt ttttacttag tgctgacgat tccgcttagc atcggtgtta actatctgga 2223001 aaaacggctg gaaaaaagct attgataagg agtgagttac attggatttc atcggtgctt 2223061 attcacagga gcatttagcg tttttatggg atggctttct cgtcaccttg tacgttgctt 2223121 tcatctccat cattctgagc tttttcttcg gtttaatcgc aggcaccctg cgttatgcga 2223181 aagttcccgt tctttctcaa ttgattgcag ttctcgttga aacgatcaga aacctcccct 2223241 tgctgttaat tattttcttt acgttttttg cccttccgga aattgggatt aagcttgaaa 2223301 ttacagctgc tgcaattaca gcactaacga tttttgaatc cgctatgcta tctgaaatta 2223361 tccgaagcgg actgaaatca attgacaaag gacaaattga agcggcgcgc tcctccgggc 2223421 tgagctatac acagaccctg ttctttatcg ttatgccgca agcgcttcgc cgcatggttc 2223481 cgcccatcgt aagccagttt atttctttat taaaagatac atcgctcgct gttgtgatcg 2223541 ccctgcctga actgattcac aacgcgcaaa ttattaacgg ccaaagcgct gacggcagtt 2223601 attttttccc gatcttttta cttgcggccc ttatgtattt cgcagtcaac tacagccttt 2223661 cactcgcagc aagacgcctc gaggtccggc aaacatagaa aaggatactc tttggagagt 2223721 atcctttttg cattaaaaca ttttcgtaat tcttcttctc atccgcttca tgcttcgatt 2223781 attcagcatg tcagattgag tcgccattcg gtacacgaga gctccggctc ccattgccaa 2223841 aagagaagtc atcgtccgat tcatcctgcg catctccttt catgattaaa aattgatgct 2223901 gcgttcatcc tcagaaaaca aatcatccaa gctgcttaac gttccgtctt cttccacctg 2223961 atgagttgca atcttccctt tcgccactgt cagttcaata aaacagcccc agcaataata 2224021 ttggttcacg ccgattttgc cgatatcctt acttttgcaa ttcgggcata taagcatacc 2224081 tcacacctct atccgttcag aacgatctcg tctttccgca cctcgacaag cgaatccgct 2224141 ctttggatct ggcgcttgct tcccgccagg tcagaaaaga aaccgtccga gagttcatat 2224201 gctacgatta tgcccctgtc caaacaaaag tatacatctt ccagcatccc caatatatcc 2224261 ccctcttgcg atttcacaag cttcatcttc atctgctcgt atgtgaagca tgatttcgga 2224321 agaggcaaaa gctgttctga actgaccgaa gccaatatgc ggtcatcaaa aatggaagag 2224381 atatcacacg cccgtaatag cgcatgatga tgatgcaaaa agcgtttttg tgcaagaata 2224441 aacccaagac aatctccttt cagagaaaaa caaatatcgg aaattgtccc gagataacta 2224501 gaagttcgtt ctgagtatac tgggaatcct tctacttcat ggcatgttct caaagtgtga 2224561 tcaaccacct tttgttgaac aggcttaggt tttgctttgc gccttagact catacgatga 2224621 aatcaattcc actgcaaatg aaaaaaaact cccgcttgca cgggagcatt ttattgctgt 2224681 tcttctttca taaaatcgaa tggtgtaatg ccttccatgc caatgttggc gtcgtgtacg 2224741 ctgaacggga gctctttttg caaagcttca agctcggcat ccatttcctc aacctgtacg 2224801 gacagcctgt ttttcaagga ggtctgtctg acagttgcat cattattttt cacgccccac 2224861 tccagcgcct cctcttcccc gcataaaatg agaaatttct tcgctcttgt aatcgcggta 2224921 taaagaaggt ttcttctgag cattctataa tagcctttca caacaggcaa aaccacaatc 2224981 ggaaattcac ttccctgcga tttatgaata gaacagcaat acgcatgggt aaattgatta 2225041 aaatcttttt tcgtaaatgt catttcattg ccgtcaaaag aaacgacggc catgtcttct 2225101 ttttctgtat tttcctttgc ataaaatatc gacgtgattt cgccaatatc tccgttgaac 2225161 acattgtttt ccggctgatt gacaagctgc aaaattttat ctccggttct gtagacaaca 2225221 tccccgaact tcaattctct ccgtttttct ttaggaggat ttaaaatgtc ctgcagcatc 2225281 acattcaatt cattaatgcc ggcttttcct ctgtacatcg gagcgaggac ctgaatgtcc 2225341 tttgctgtat agcctttttt caatgcattg gcgacaacct tctcaactac ttctttgatt 2225401 tgcgacccgc cgcagcgaat aaaggaacgg tcctttgtcg gggcagtcaa attgttcggc 2225461 agcaatccat ttttcatctg gtgggcaagc tcgacgattg atgacccttc tgcctggcga 2225521 tagatgtctg tcagtctcac agtcggaatc acctgggatg ccagcaggtc tctgagcact 2225581 tgtcccggac cgacggaagg cagctggtct tcgtctccga caatgatgat ttgtatatga 2225641 tcagggatcg ccttgaacaa atgattcgcc agccatatat caagcatact ggcttcatcg 2225701 ataattaaca gcttcccttc gatcggctga tcctctgtat gagtaaagcc ttcagcgccg 2225761 ttccagccaa gcagcctgtg tatcgtaact gcagggagtc ccgttgattc actcatccgt 2225821 tttgctgctc tccctgtcgg agcggccaaa acaatcggaa aagcttcatc ctttttataa 2225881 gctgacgggt ctagtgacac accgtgaagc tctccgtaga gctcgacaat ccctctgatt 2225941 accgtcgttt ttcctgttcc cgggccgcct gttaaaagaa gcatcggcga ggaaagggct 2226001 ttttgaatcg cttccttctg gctgggggca tactgaacgt ccatccgttc ttccagttct 2226061 cccaacgcga gcaaaaactc tgattcggga aactggttct catattcggt ttggctagcg 2226121 atatgtttca cacgctttgc aacgttttgt tctgcgtaaa acagcgaagg aaaataacag 2226181 cggccatctt ctatgacaat gtctttattt tctccaaggg caataattgc gttagcggca 2226241 tccatttctg taatgcgctg cccttccctt gctgactggt ttaacagtga ttgagtgtcg 2226301 atgatcagct gttccgtttc tatgtacgtg tgcccctctg acagacaagt cgtttcaagc 2226361 gtgtacaaaa tagcagcttt tacccgctca ggatgattac ccgaaagacc cattctgctg 2226421 cccagctcat ccgcttttcc aaacccgatg ccttctacat ccttcacaag ctgataagga 2226481 ttttcctgaa tcttttcaag cgtctcggat tcataggctt gatagatttt catagacagc 2226541 tgcgggccaa agccaaactg attcaaggaa atcatgattt gctccagtcc ctgatgccgc 2226601 tgcaatgcgc cagccagcgt gtctgctttc ttttttgaga gtctgggaac atcataaagc 2226661 actgaagcat cagccaatat tttattaatg gcgctgtcgc ccagcttttt cacaatttct 2226721 tcagctgttt ttttgccgat cccctcgaat aaatcactcg ataaatattg aatgatgcct 2226781 tccttagtcg ttggaatctc ctttttgaaa tgctccgcct gaaattggag cccgaatttt 2226841 ggatgggtta cgatctttcc gtaaaacgtg taggtctctt cttcttgaag cgcagggaag 2226901 tagcccgtca cggatacggc tttatcttca atggcttcgg aggtctctgt gactttcact 2226961 ttcagaaccg tatataaatt ggtgtcatta tgatagatga ctgtgttgac tgtccctttt 2227021 aaatagggct cttcctccag tttaagctga tccggatgct gctgcacgag ctgtccctcc 2227081 tcctgtgcct gttatgatgg atcaatcagt tttttagcat gaagcgcaag catatgatct 2227141 ggctggatat cgattgcctt gtccagcatt tccagcgctt tttctcggtt ttctttataa 2227201 gcataagtga caccggcatt ataaaatgca tctgcatgcc ccgggtcttg ctctgtcaca 2227261 gctgcgaatt ggctgagcgc ttcgtccagc atgccctcgt tggctaagca catcccgaat 2227321 tgaaaacgcg cttccgtatc gttttcattc agttcgactg ctctttgtaa atatggcagt 2227381 gcaagcttag gctgttcgag cttgacaagt accgttccga gcatgtaaaa caggtcgccg 2227441 ttttccatcc ccgcacgtag cgctttttca aacatgtctt tcgcttcttt gtacatttct 2227501 tttacaacat agacatttcc tgctccataa taagcagtgg ctgcgctact gtctaattca 2227561 agcgctttat cataaaacgc aagcgcacgt tccagctcgt ttacggatga aagaaggttg 2227621 gcaaaattga tatacggaat cgcgtcttct ttattttctt caatcgcttt tgtaaatgcc 2227681 tctgccgctt tctcgtaatc gccttcctgc atcgcctcta taccgagttg attataatcc 2227741 accgatcatc ttcctttcat taaaaaaccc caactcagtg ttgaggtttt tcatctttta 2227801 tacgtaccac aattttgttc cgtctttgta cacatcatca attgtcccgc cgccaaggca 2227861 ttcttcgccg tcatagaaga caacggcttg tcccggcgtt acagcgcgga cttgttcatc 2227921 aaagatgact tccgcttcac cttcgccagt catgcgcact gttactttat gatcctcttg 2227981 gcggtaacgg aatttagccg tgcaggaaat ctcttcgccc ttcatgatat ccgaacgtac 2228041 ccagctgata tttgttgctg tgattttgtc ggaatataaa agcgggttat ggaacccttg 2228101 atctacgtag aggatgttct tttcaagatc tttgcctacc gcaaaccacg gctcgccgct 2228161 tccgccgatg ccaaggccgt gacgctgtcc gatcgtatag tacatcaacc cgtcgtggcg 2228221 gccttttact tcgccgtcca tcgtcatcat atcgcccggc tgtgcaggga gatattggct 2228281 gagaaacgtt ttgaagttgc gttcgccgat aaagcagatg cctgtactgt cttttttcgt 2228341 cgctgttgca agttctgctt ctttggcaat ttcacgcaca cggctttttt gaagttcgcc 2228401 gatcgggaac atgactttgc tcagcgtatc ttctgtcagc tgattcagga agtacgtttg 2228461 atccttgttt tcatcaatgc cgcgcagcat tctgactttt ccgccgcttc tgtctactct 2228521 tgcatagtgg ccagtcgcta aatagtcggc gccaagtgac aatgcatgct ccaaaaaggc 2228581 cttgaattta atttctttgt tgcacaatac atccgggttt ggtgttctgc ctgctttata 2228641 ttcatcaagg aagtattgaa ataccttctc ataatattgc ttttcaaagt ttacggcata 2228701 atacggaatt ccgatttggt tgcagacgcg gatcacatct tcataatcct ctgtcgccgt 2228761 gcaaaaaccg ttttcgtccg tatcatccca gtttttcata aagattccga ttacatcata 2228821 gccctgttct tttaacagca gggccgccac agatgagtct actccgccgg acatgccgac 2228881 gacgactctt gtatcctccg gccgtttttc catttcattc actccaatta ctacgccgcc 2228941 ttattatgtc agccgtttga caacgtcggc cacatgtttg gcagcagttt tcacttgctc 2229001 agccgtattg ccgaggccga agctgattcg aatagaggac gtcagccggt cactctcttc 2229061 gccgaacata gcagtcagaa catgtgacgg caggactgaa ccggccgtgc acgctgaacc 2229121 gctggagaca gcgacaccag ccatatcaag attaaccagc agcgcttcca ctgacacacc 2229181 ggggaaataa agattcagaa catgcggcag actatgctct ttgtccccgt tgacctcgaa 2229241 tgccacacct gcatctctaa gcgtgtcggc aaagattgct ttaaacgatt gatacttctc 2229301 gtttttttcg tcacgttctt cacttgacag cttgatcgct tctttcagcc cgacaatgcc 2229361 tggaacattt tccgttccgg cacggcgttt tctttcttgc tctcctccga ataaaagggg 2229421 tgaaagcttc acatctttac tagcatataa aaagcctgtc ccttttggcc cgttgagctt 2229481 gtgcccggaa acagacagaa ggtcaatatg gctgtttttc acatcaattg gcagcaaccc 2229541 gaatgcctga acagcatcgg tatgaaaata agctttgtgt tcctttaaca gctcaccgat 2229601 ttcttcgatc ggctgcactg ttccgacttc attatttcca tacatcactg tcacaaggat 2229661 tgtatcatca cgcagtgctt ctttcacctg ttttgcactg actcttccat tttggtcaac 2229721 gtccagatac gttatgtcaa atccgtctcc ctcaagtttt tcacatgtgt gaagcacggc 2229781 gtgatgctca atttttgttg tgatgatatg tctgccaaga tcttttcttg caagtgcggt 2229841 tcccatgatc gccaagttat cagcttccgt tcccccgctt gtaaaaatga tctcctgctc 2229901 tgccgctccg atttctgctg cgatctgcgc tcttgcttca tccacccatt ttcgagattc 2229961 tctgccaaat gaatgaatac tggagggatt accgaaactg ccggagaagt gcggtatcat 2230021 ttgttccagc acgcgctcat ccatcggaga cgttgcggca tgatctaaat aaatccgttc 2230081 cattatgttt acacctctga tctaaatata gaacatataa gcttcttgct ctccgtctgt 2230141 atagctggca agatcctcta atgttgtact gtctaaaacc tcttttacag catcccggat 2230201 gcgaatccag agctcacgct tggcaggctc ctcatcttcc agcacttcaa cagggctgat 2230261 cggcccctca agcacacgga taatatctcc cgcagtaatg gcatccggct cactgcctaa 2230321 tacatatccg ccatatgcgc ctctgatgct tttcactaaa ccggcatttc tgagcggcga 2230381 taccagctgc tccaaataat gctcggacaa attattcgtc tgtgcgatgc tttttaatga 2230441 agtcgggcct tcaccgtgct tttttgcaag ctcgatcata atggtgagcc cgtatcttcc 2230501 cttagttgat attttcaaca tgaacacctc tgttatttca tgattttcca catttataat 2230561 ggtaatttct atatgtttcg tccgtttatt atcttataga ccaactgtta ttataacata 2230621 ccttcagcga attttcattg aggcagaagg aaaggggcct ttaccctttt ctaatgtacg 2230681 gttttccgtt accctgtaat taagtaagga gagatgatag atgaagccat tggcatatcg 2230741 gatgcgtccg acaaaaatag aggatattat cggccagcag catctggtgg ctgaagataa 2230801 aattattggc agaatggtcc aggcaaaaca tttgtcatcc atgattttgt acgggccgcc 2230861 cggaattgga aaaacatcaa tcgcaacagc aatcgccggt tcaacaagta ttgcttttcg 2230921 aaagctgaat gctgtcatta acaataaaaa agatatggaa atcgtagctc aggaagccaa 2230981 gatgtccggc caagtgattt tgattctgga tgaagtccac aggctggata aaggaaaaca 2231041 ggattttcta ttaccctatt tagaaaacgg aatgatcatt ttgatcggag caacgacggc 2231101 taacccgtat catgccatta atccggcgat cagaagccgg acccagattt ttgagcttga 2231161 accgttaaca cctgaactga ttaaacaggc actggaacgt gcgctccatg atgagcatcg 2231221 gggccttggc acctattctg tatccattga tgatcaggcg atggagcatt ttgcccacgg 2231281 atgcggagga gatgtccgct ccgctttaaa tgcgcttgag cttgccgtgt tgtcaacgaa 2231341 ggagtcagca gacggtgaaa ttcacattac attagaaacc gcggaagaat gcttgcagaa 2231401 aaaaagcttt tctcacgata aagatggtga cgcgcattat gatgtactgt ccgcttttca 2231461 aaaatcaatc cgcggctctg atgccaacgc tgctcttcac tatttggcta gattaattga 2231521 agccggtgat ctggagagca tcgcaagacg attgcttgtt atcgcctatg aggatatcgg 2231581 tttagcaagc ccgcaagccg gccctagagt gctgaacgct attcagaccg ctgagcgagt 2231641 cgggtttcct gaagcgcgaa tcccgctggc caacgcagtt attgagcttt gcctctcacc 2231701 gaaatcaaac tctgccattc tggcaatcga tgaggccctg gcagatatca gagccggaaa 2231761 aattggggat gtcccgaagc atttaaaaga cgcgcattat aaaggagctc aggaattagg 2231821 aagaggaatc gactataaat acccgcacaa ttacgacaac ggttgggtcg aacaacaata 2231881 cctccctgat cctctgaaaa ataagcaata ctataagccg aaacagactg gaaagttcga 2231941 atctgcctta aagcaggtgt acgataaatt aatgaaaaga aaataaaaca aaaaaacagc 2232001 cttgatcatc aaggctgttt ttatgcatta tttatccttc acacgtttga tttcaatgtc 2232061 tttcaaaaga tccatgacaa catgtccgcc cataatcaaa cctgcaactg acggcacaaa 2232121 agcattagag gaaggcggca tttttgcttt acgtattttc gcttcgtcat tccccacttc 2232181 ttttctgaca tcttcccgaa taacaatcgg gctttcatca gagaaaatca cttgaacgcc 2232241 ttttttgata ccctccttgc gtaatttcgt acgaacgacc ttcgcaattg gatcagtgtg 2232301 cgtttttgag atatcagcga tttggaagcg tgtcggatcc gttttatttg cagcacccat 2232361 gctggagatg agcggaatat cccgttttag acattctttc attaaatgaa ttttataaca 2232421 aatggtgtct gacgcatcaa tgacatagtc aagaccatag tcaaaaaact gctcatacgt 2232481 ttcctccgta tagaacattt ttaacgcgat cacttcacac tccgggttaa tgtctgcgat 2232541 ccgcgccttc attaaatcaa ctttcggctg tccgacagtt gaaagcagcg cgtgaagctg 2232601 acgatttaca tttgtaatgt cgacatcatc tttgtcgaca agcagaatgc ggccgacgcc 2232661 tgaccgcgcg agagcttccg ccgcgaacga cccgactccc ccgactccaa gcacagcaac 2232721 tgtgctgttt ttcagcgttt caaggccttc ttttccgata gctaattcat tgcgtgaaaa 2232781 ctggtgtaac aagaacctca ctccacattc gtattctggt ttcatctata aaatggctga 2232841 tccatgagca gccgtttttt ctgcgcacaa aaaataaagt cccaatagtg ccgttgcagc 2232901 tttcctttgt tttgaacccg ctctcagcag gtgggtgccc tcttttaaat cttgtaagtc 2232961 ctctttaccg aatgaaaaga ggcatgtacg ccatttaaaa atgcgggctc ccaaatcaaa 2233021 aaaatgttcg gtcaaaacta ggtgtacaac taacacatca ggactttatt taacttgtca 2233081 aaatcatatc acagacgatt ttgattttca agaatcgaac tgcaaattca gttcttaact 2233141 tttttcttga tagaaagatg aagctcgtca agctgggcgt cgcttacttc gcctggcgct 2233201 tctgtcatca ggcagcttgc acttgccgtt ttcgggaatg caatcgtatc tctcaggttc 2233261 gtacgtccag cgagaagcat aacgagacgg tctaagccga gtgcgattcc gccgtgcgga 2233321 ggagcgccgt attcaaatgc ttccagcagg aatccgaact gttcagccgc ttcttctggt 2233381 gagaagccga gaagcgcaaa cattttttcc tgaatatcct tttcgaaaat acggattgaa 2233441 ccgccgccaa gctcatagcc gtttaagacg aggtcataag cttgcgcttt catgtcttca 2233501 ggcgctgttt caatcagctc aaggtcttct cggacaggca ttgtgaacgg atggtgcgct 2233561 gcgtaaaaac ggccttcttc cggatcatgc tctaatagcg gccagtcgat gacccataag 2233621 aaattgaaca atttttcgtc aatcagtccg cgttctttcc caagctttaa gcgcagggcg 2233681 ccgagtgatg cggccacaac ttcgaattga tccgctccga acagcagcaa atcaccttca 2233741 gcagcatcaa gtgcttcaat cagcttagac tgcttttctt catcaaagaa tttagcgatc 2233801 gggcctttca ctccgtctgc ctcaaccttc acccaggcaa gcccttttgc cccgtagttt 2233861 gcagcaaaag cgccaagagc gtcgatgtct tttctggagt aatcgccggc accgcctttt 2233921 acattgatgg ctttgaccac gccgccgttt gctacagctg atgagaacac tttaaattcc 2233981 gtatccttta caatgtcaga cacatccgtc aaaagcatgt caaaacgcgt atccggttta 2234041 tcagacccgt acttgttcat tgcttcgtca tacgtcattc gaggaagagg aagctgaagt 2234101 tcctcacctt ttgtttcacg cataaccttt gccatcatct cctcagccaa tgacataatg 2234161 tcttcctggc tcataaagga catttcaata tcaatttgcg taaactcagg ctgacggtcc 2234221 gcacgcaagt cttcatcgcg gaaacagcgg gcaatttgat aatatcgttc aatgcctgat 2234281 accatcagaa gctgtttaaa tagctgcgga gactgcggca gcgcgtagaa ctcaccttcg 2234341 tgcacacggc tcggcaccaa gtagtcacgt gcgccttcag gcgtgcttcc tgttaaaatc 2234401 ggcgtttcaa tatcaagaaa cccattttca tctaaaaagc tgcgaacagc tttcgtcacg 2234461 ttatggcgca gctgcatcgt ctggaacata gccggtctgc gcaaatctaa gtaacggtgt 2234521 tttaaacgaa cgtcctctga cacttcttca gcttgatcag aaatcgcaaa tggaggtgtc 2234581 tttgcagcat ttaatacgtt cactccatca gcatgtattt cgatcgcgcc tgttttcaaa 2234641 ttcggattaa ctgttccctc ttcacgcgcc accacttttc cttgaatatc aagcacgtat 2234701 tcatttctga tgccttccgc aatagcaagc gcttcttttg acacatcagg gttaaaaacg 2234761 acttgaacaa tgcccgtacg gtcacgcaag tcaataaaaa tcaatccgcc gaggtctcgt 2234821 cttttttgga cccagccttt cagcgttaca gattcgccaa ttgctttttc agttatatca 2234881 ccgcaataat atgttcttcc aaacaatgcg tttcactcct tatccctttt ggtttgcctt 2234941 catcacatgt ataaattcat caagtgccac ttcaatctgt tcgcccgtct gtgcatcctt 2235001 tacattgatt ttgttttggg caagctcatc ttcacccaaa atcgcaataa atctggcctt 2235061 taagcgatca gctgttttaa actggccttt cattttctta ttttcataat cgatttcact 2235121 ggaaatgcct gcttctctca gtttgtacac caatgaaaca gaataatcct ttgctttttc 2235181 gccgagtgtg acgatatagc agtcgattcc cttatcaaca ggcagctctc ttttttcagc 2235241 atcaattgcg gcaagcaagc gttcgatgct catcgcaaat ccgatgcccg gtgcttcagg 2235301 tccgccgatc tgttcgacaa gcccgtcgta gcgtccgccg ccggcaagtg tcgtaatcgc 2235361 gccaaagccc tccgcattgc tcataatttc aaatgcggtg tggttgtaat aatccagccc 2235421 tctcacaagg ttcggatcga tttcatacga aatgccaaga tcatttaagt attgtttcac 2235481 tttttcaaaa taagcggctg attcttcatt taaatatgtc aaaatcgaag gtgccgattt 2235541 catcagctca tgatcacggt cttttttgca gtccaaaatt ctaagcgggt tcgtgtgcag 2235601 ccgggactgg cagtctgaac aaaattcttc gatgcgaggc tcgaagtgtt tcacgagcgc 2235661 ttctctgtag cttttgcggc tatcttgatc gccgagactg tttatgacaa gcttaacgtt 2235721 ttctaaacct gctttttcat aaatactcat cgcaagcgcc attacttcag cgtcgattgc 2235781 agggtctttc gaaccaatcg cttcaattcc aaactgataa aactggcggt aacggcccgt 2235841 ctgaggacgt tcataacgga acatcggccc gacataataa agctttgtcg gctgtacagg 2235901 atttgcgaac agcttgtttt cattaaaagc gcgaaccgca gcagctgttc cctccggacg 2235961 aagcgtcagg cttctgcctt tgcggtcctc gaaggtatac atttcttttt gtacgatatc 2236021 cgttgattct ccgacgcctc tggcaaacag ttctgtatgc tcaaaaatcg gtgtgcggat 2236081 ttctttatat tgataagtgc ggcaagtgtc tctcataatt tgttcaacaa actgccagcg 2236141 atctgattct ccaggcagaa tatcctgtgt tcctctcgga atgttatatc ccataggtag 2236201 acctccttat gtattcctta taaaatatcc aatgatcgtt aatgatgaaa atgaaaaaaa 2236261 ctcccgcccc tactatacat gatagtaggg acgagagtta tacccgtggt gccaccctag 2236321 ttggaatacg ttcatattcc cgctcgatcc tttaacgcag gttcacgttc actgcctaat 2236381 ggcgttattc acgcgttcag caggaaacct ccggagtgtt gtttcgagaa agacgcaatg 2236441 ggatccgctt tcagcctggg gcgggttcct ctctaatcat gcaatctgac ctactcttct 2236501 ccattattgg ttcaaatctt tcatcatttg ctatgtactc aatttctatt ataataatgg 2236561 gattggggtt ctctgtcaag ctttattccg gttgtttttc ctcagcgctg cttctttgga 2236621 cataagacca aattcagatg ctgtttccgt aagataacca gtcgtatcgg gatctgcgtg 2236681 atcgctgtaa tgcagattcg cttcaccgtc gtgaaatgca cgtcccattt ttggatgata 2236741 tttcatgatt tgcacacctt tttgattgta tttacgctta gtataaacaa atcattttat 2236801 ttttatttaa aaatcagaaa ggactttacg atattaaaca agaatgcttt tttaatgatc 2236861 atcagaaagg aggacacaat gaacaagaaa tactttgtcc ttattgtatg tattattttc 2236921 acctcagcgc tattcccgac cttttcatcc gttacagctg ctcaaggaga agcggtcatc 2236981 gcaacagatg aaatgaacgt cagaagcggc ccagggctta gctacggcat tacagcggaa 2237041 gtaaaaaagg gagaacgcta tccaatttta aaggaagatg gagactgggt gcagatacag 2237101 cttggttctg gagaaaaggg ctgggtagtc tcctggctta ttacaaagga agaccaggcc 2237161 agcacaagct cctcaggaag cagtgacact gtgacatcaa cagaccccga tctgcggatg 2237221 agaagcggcc cgggcacttc ctacgaagtc atcggcaaat tcccgcaagg cagccaagca 2237281 tctgtcattg ataaagattc gggctggatc aagatatcct atcacagtgc caccggatgg 2237341 gtatcatctg aatatgtcac atcaggaggc agcagttcag cgtctgatga gagtgaccaa 2237401 accgaggatt ccggtgcgtc aacgacgggc acagtcggtg tttcttcgct aaatgtaaga 2237461 gcctccgcct cacatgacgc ggcaattata acaaaacttg atcgcggaac gaaactgacg 2237521 gttctcaacg agaaaaatgg ctgggctcac attgaggtga acgggctaaa aggctgggtt 2237581 gcaagccatt accttttgac tagttctgtt ccagctgatg attcagcaaa tgccggcagt 2237641 tcatcctccg ctaaaaaagc ctatatcatg tacggaggaa cgaatctaag aagtgatgcg 2237701 tcaacatcag cttcgatcgt tgagcgcgct gccaaaggag attcatacac cattaccggt 2237761 tcaaagggaa gctggtatga aataaagctt gataacgggc agactgctta tgtagccaat 2237821 tgggtggtcc aaacgtctaa aagcgcagaa gaagcaggtg aaccgccagt ctctgattcc 2237881 ccgtctggaa acggctctct aaacaataaa acgattattg ttgacccggg acatggagga 2237941 aaagacagcg gaacgatcgg gtattcgggg aaattcgaga aaaacctgac gatcaaaacg 2238001 gcaaaactgc tcgccagcaa acttagatcg gctggagcgg atgtatatgt gacacgccag 2238061 gatgatacct ttgtcagcct gcagtcacgg gtctctacct ctcactaccg taacgctgac 2238121 gcctttatca gcattcatta tgacagctat gcggatacct ctacaagagg cagtacagca 2238181 tattactaca gtcctgccaa agatcaggaa ctcgcatcag atgtccactc agaagtggtg 2238241 aagcgttctt ccattccaga ccgcggcgta ttattcggag attattatgt gctccgggaa 2238301 aacagacagc ccgctatgct gtacgagctg ggatatgtaa gccatccgca ggaagaagcc 2238361 attgtacata gcaattcata ccaagaaaaa gtaacagatg ggatcgaaag cggattagag 2238421 aaatacttcc aataaaaaaa gctgcctttt ggcagctttt tttattttga atccataatg 2238481 agcgtgaccg gtccggagtt tgtaagctga acatccatca ttgctccaaa cgttccggtc 2238541 tccactttga ttcctttttc acgaagcagg tcattccatt tttcataaag acctaaagct 2238601 ttatcaggtt tggccgcgtt catgtagttc ggccggcgcc cttttttcgt atctccataa 2238661 agcgtaaact gtgagacgga taaaatctct cctcctatat ctacaagaga cagattcatt 2238721 ttcccttcac tgtcatcgaa aatacggaga ttgacaactt tatcggctaa ataagctgca 2238781 tcatcttctg tatcatcgtg agtgatgccg accagcacca taaggccttg tccaatttgg 2238841 ccgacgacct cttcgtccac tgtaacgctt gcttctgtta ctcgctgaac aactaatctc 2238901 ttttctaacc cctttagttc atgacgcggc gcacagaata gatatctcta atctgtttaa 2238961 tacgctcgac gactttatgc aagtgattga tattctggat aaaaatcgcc atatggatgg 2239021 ttgccacttt attgcgatcc gatttgccag agacagatga aatattggtt ttcgtttcat 2239081 tcactgcctg gagtacctcg ttcagcaatc cgcggcggtc atacccaaga atctctatct 2239141 caacattgta ttccttgcgc ttttgaactt gtgactcatg ttcccactct accgggatca 2239201 gccgctcttg ggcttcattc gttttgacat tcggacagtc ttcgcgatgg accgaaaccc 2239261 ctctgccttt tgtgataaag ccgacaatat catcacctgg cacaggattg cagcattttg 2239321 ataaacggac aaggaggttg tcaatgccct tgacacgaac gccagcttcc cgttttcttc 2239381 cttgcgggta tggcttaggt tccccagtga cttcctgaac gatcttttcc tgttcttcct 2239441 ggtcgcgctg ctttctctct ttttctgtta ggcggttcgc cacctgcaga gctgtgatgc 2239501 cgttgtaacc gaccgccgcg tacatatcct cttcatttga gaaattaaat ttgtcagcaa 2239561 ccttttgaat attctccggc gttaaaacat ccttcaattc aaaatccaag tttttaattt 2239621 ctttttcgac cagctcacgg cctttttcga cattttcttc acgccgctgt ttcttaaaga 2239681 attgacggat tttatgcttc gcttgggatg tttgggcaag cttcacccaa tcctggctcg 2239741 gaccgtagga atgcttagag gtgagaattt caacgatatc acctgtccga agcttatggt 2239801 caagcgtaac catttttccg tttactttgg caccgattgt tttattgccg atttcagagt 2239861 gaatccggta agaaaagtca atcggaacag aaccggacgg aagctcgatt acatctcctt 2239921 ttggcgtaaa gacatacacc atgtcagaga acaaatcaat tttgagcgat tccataaatt 2239981 cttctgcatc tgtcgattca ttttgaaatt ctaaaatttc acggaaccaa gaaagctttt 2240041 tctcaaaggt tgcaccttca ttggctgctt tcccttcttt ataagcccag tgagccgcaa 2240101 ccccgtattc cgctatttca tgcatttcaa aggtgcggat ctgcacttca agcggatcgc 2240161 ctttaggccc aataaccgtt gtatgaagcg attgatacat attcggcttc ggcattgcga 2240221 tataatcttt gaatctgcct ggcatcggtt tccagcatgt gtgaatgatg ccaagcaccg 2240281 cgtagcagtc ctttatgcta ttcacaagaa tacggacagc caacaaatcg taaatttcat 2240341 tgaattgctt attttgcagc accatttttc gataaatgct gtaaatatgt ttcgggcgtc 2240401 ccgagaagtc agccttgata tttacttctt cgacacgttt cttcacttca ttgacaacct 2240461 catcgacata aagctctcgt tctgcacgtt tcttcttcat gaggttgaca attctgtaat 2240521 attgctgagg gttcaaataa cggagcgccg tatcttccaa ttcccactta atttttgaaa 2240581 tcccgagacg atgcgccaaa ggagcaaaaa tttccagcgt ttcattggag attctccgct 2240641 gtttttcctg aggcagatgt ttcagtgtcc gcatattgtg aagacgatcc gccagcttga 2240701 tcaatatgac cctgatatct tgagccatag cgacaaacat tttgcgatga ttttccgcct 2240761 gctgttcctc ttgagattta tatttaattt tgccgagttt cgttacgccg tctacaagca 2240821 ttgccacttc ttcggaaaat gcttctttca ggtcatcgag cgtcacatct gtatcttcca 2240881 cgacatcgtg caaaaatccg cccgcgattg tggaagggtc catttcaaga tcaacgagta 2240941 tccccgcaac ctgaatcgga tgaataatat atggctcgcc cgatttgcgg tattgctcgc 2241001 gatgagcatc ttcagcgtac agatatgctt tttcgacaaa tgcgatatgc tcatcagata 2241061 gatagctgcg tgctttatct ataacttgct cggcagtcaa tacttgttcg ttcgccatgg 2241121 aatcaccttt tttaaaatgt aaactgtatt gtagtttatt atcaagaaaa aaacgaaaga 2241181 tgtaaagagc agaagttcaa atagccaaat attatataaa ataaatgcaa aacaatagga 2241241 aaaaagcacc ctgacatgga gtgctttttc gttatgcggt tatccttagt atttcatcaa 2241301 tgttaagatg tcgtaatctt cgagcttatt tctgccgtca aggtaagaaa gctcgattaa 2241361 gaaagcgata ccagcaacaa cgccgccaag ttcttcaaca agtttgattg tcgcttcaat 2241421 tgtgccgcct gtcgcaagca ggtcatctgt aataagcaca cgctgaccag gcttaatcgc 2241481 atctttgtgg atcgttaata cgtcttttcc gtattccaag ccataatcca ctttgattac 2241541 ttcacgaggc aacttgcctt ctttgcggac cggcgcaaaa cctacgccaa gcgcgtaagc 2241601 aacgggacag ccgataataa agccgcgcgc ttcagggcca acgaccaaat caatttgctt 2241661 ttctttcgca tattcaacaa tttgatctgt ggcatagcgg tatacatcgc ctttatccat 2241721 cagtgtcgta atatctttaa attgcacgcc ctctttcggg taatccggta caattgttac 2241781 gtattgtttt aaatccatct gttttatgtc ctcctcgtac tttcataagc ctctgaatct 2241841 tgtttcatca gcttattcag ccattccttc agctcttcag cagaagaata attcagcttt 2241901 tgatccagtt ccatcagctg ctgtttcgcc tgatatgttt gtgagtctgt taagtcgcgt 2241961 ttctttgctc cgctcacaac agacagcaca ccattctcta ttttaacaaa accgagatca 2242021 aaaaacacct ttgtcatgaa attgattgtt tcaacggacc agcctttatg ttttgcaagc 2242081 tctgaaccgt gttttttcac gtcaaaagcg cctcttttca gcaagaacgc ataataccat 2242141 ttaaagtggt ctcttgcggg aaaagttgat aaaaagtggt cctcatgatt gagaaaaata 2242201 aaatatatcc gctcgggcgc ctttccttcc agcaaacgtg cgagcatgtc cagcgaaggc 2242261 ggcggatcca gtaatacaat atatgcacca tcgaggtcaa acgcctttgc ttgatcttta 2242321 gaactgatga cgtgcacttc tcggcgaagg tcttcagttt gaagtaatgt tgttgagtct 2242381 tctttgaaag agacaatggc ccgtttagca gatggaaggg cggaaactgt gtcttcccac 2242441 gtccgttttc cccttaaatc aaacagctgc cattcagaaa cagcggcatc ctttatcata 2242501 agctgcggct tttttcgatt gttccattcg ttgattgaca tctcaccgac aatggaaatt 2242561 cttgaacccg gtacgatgcc ttcttgaagc tcgcctttat taaaaccgac gcaatcaagc 2242621 tgggacgact cgtttctgat cgtcattttg acatgagttt tatttgcccc tatcttgcgg 2242681 acatcttcca gtactgcatt ttctacgaga acgtgcggtt tcgggttcag catgccaaaa 2242741 ggagacagca tgttcatttc tgcgatgctt tcaactgtaa tgtcttcgac gccgcagaca 2242801 aggtcgactt cctgtacggg aataaaatcc tcttccgtaa gcgtattgtc cgctatttca 2242861 ttcagcctgc ttcgcaaatc cggcacatct tcggctttca gcgtcatccc cgcagccatt 2242921 ggatggccgc cgaaatgagg aagaatatct ctgcattcag aaaggctctc aaataaatta 2242981 aatcctctga tgcttcgggc cgaaccttta gcgattccct tttcttcatc aataccaaga 2243041 acaatggccg gtcggtagaa acggtccaca agctttgaag ccacaatccc gacgactccc 2243101 gggttccatc cggctttggc cacgacaatt gcagtttgat cgagcccttg ctgttcaacc 2243161 atttcaatcg cttcatccgt cattttgctg accatttttt ggcgctcttt gttcagctgg 2243221 tcaatttctg cggcaagctc ttccgcttca aacgaatcct ctgacataag caaatgaaca 2243281 gcgggatccg cctgttcgat tcttccgacg gcattcagcc ttggtgcgag ctgaaatccg 2243341 actgtttctt cgttcgcttc tccgatgtct ccgcctgaca gcttaatcag ctcttttaag 2243401 ccgagccgat ttgtccgtcg aagcctttca agtcctagtg ttgctattaa tctgttttcg 2243461 tcatgcagcg ggactagatc ggcaatggtg ccgatagccg ccaggtcaag cagttcatca 2243521 ggaagttcac ccaataaagc gtgggcaagc ttaaacgcga ctccaacccc ggcaagctct 2243581 ttaaacgggt aagtgcagcc aggctgcttc gggtggacga tcgcacggac atccggaagc 2243641 tccggtcccg gttcatgatg atcggtaatg atgacatcca gtccgagttc ctttgccacc 2243701 ttcgcttcat gcacagcggc aattcctgta tcaaccgtaa tgatcaaaga gaagccccgt 2243761 tctttaatcg aacgaaacgc ctgttcatta ggtccatatc cttctttaaa acggtcaggt 2243821 atataaaaat caacttgagc cgacagtttt tgcagcgtgt gaagcatcac tgacgtactt 2243881 gtaaccccat cggcgtcata atcgccatat atcataatct tttcttgttg tgaaatcgcc 2243941 tgttttattc gatctgccgc ttctttcatg cctttcattt caaaaggatc ataaaaatcg 2244001 gcatcctttg tatgtaaaaa cagcctagcg ctttctgccg tatcaaagcc tctttttaca 2244061 agcagggacg caacaagagg tgttatatgc aattgttctg tgagtgattt gaccttatcc 2244121 tgatctggtc gctggatttc ccatcgcatt tttgacgcta acataaattc acccctcaac 2244181 caccctatta tactagagca ggctgagggg tttcaaataa tattcgaaaa ctagtctttt 2244241 ttctcaatca tggctgatgc atcctgtgtg tcagtctgat cagcaagatg agtatcctct 2244301 tgtttatgta ttgctgttct attttctttc cgcaaggttt ttatttcccg cttcaatttc 2244361 attacctgaa aaatgccgac agaaaatacg atcagtgctc ccattaaaac tgagcccaaa 2244421 ataacaagaa tgagcggcca ttctgatctt ccaaacaggt aatcaacttc tacggatcga 2244481 acattaatga ctgcgaaaat agcgacaatt aaggtgaaaa taagtgcgaa aataatggtc 2244541 cattgtttat tcattctctt ttcccccaaa cttcttattg aggtaacttt cccaatcaag 2244601 actggtttta aacatggctt aacactaggt taagctccct ttgctgttaa tttttcccgg 2244661 atcagcctct tcagtccggt tccctcaccg gaaatcacaa gtgtatcgcc ttcgtcaatg 2244721 actgtttcag agctcggatt cagttgttta tcctgattct ttttaacaat tgcaatgacc 2244781 gtcacatgat attcctgacc cacattcaaa tcaccaatcg tctgatgaat ggcaggcgct 2244841 cccgcctctg ctttacacca ctctataatc aaatcatcaa gggctgactc gacctgttct 2244901 aatgctttcg gtttatatgc cattccgcca agaattgcag acatttgcct tgcttcagcg 2244961 tcatcaaact gcacggaggc aacacattcc tcatggtcgt tttcgtcaaa atagtaaagc 2245021 tctctccgtc cgtcatgatg aatgataatt gaaattttat cacggtttct agtaatcatt 2245081 tcaacttttt gtcctatgcc cggcagctct gattcgcgaa ccctcatata taaaccctcc 2245141 tacatatctg aaaaccagcc ataaacactt ttaacaccat atatatgttt aaatgtaagc 2245201 gtatgtcatt atagcaaatg tctattttaa gttcaatgaa acttcaaaaa acaggctgcc 2245261 ctgcagagga cagcctgata ttttttattg cgccgaatct tttttcagtt ctcttccttt 2245321 ccatgcaagc caaatttgtg cggcaatgta tagagaagaa taaacgcctg ttaacagccc 2245381 gaccaataaa gcaattgaga agttagtaat agaagatgct ccaaagatca gcaatgtcac 2245441 aacaacaatc acaacggtta atacagtgtt aattgaacgt gtaaaggttt gctgcaggct 2245501 caggtttaca atatggttca gatcggcaaa ggttttcggc ttacgctttt tcatatgctc 2245561 gcggaccctg tcaaatgtaa cgattgtatc gttaatggaa tacccgatta tcgtcaagat 2245621 ggccgcgatg aatgtaacat ctacctcaag ccttgtaata ctgaagaacg tgacgataaa 2245681 gaatgcgtca tatagcaatg aggcgatggc agcaatcgcc attttgtatt cgaatcggat 2245741 tgaaacgtaa ataatgatgc caatagaagc tatagcaact gcgtacagcg catttctcgc 2245801 cagctcctta ccgactgtcg gtgaaactgt gctgacattt ggatcagatc cgtatttgtc 2245861 tttaaaatac gtttttactt ttgcaatggt ttctttatct ggcaccccga caaaacgggc 2245921 aacaccgata ttgctctttt cgcctgacag aactacagta tcagggtcca tacccagaga 2245981 ttcaaaatcc ttctcaactt gctctgtcgt cagcttatgg tcgctttgca cttcaatccg 2246041 tgcaccgctt gcaaagtcaa tgccaagatt cagcctgaac acaagcagga taataatccc 2246101 ggcaaccgtg accgcactgg agaaaataaa gaagtatttg cgtttgctcg tgaaatccca 2246161 tttttggaat ggcgtatgcg gctctgtatt ttcatccgta tcctgaatat ccatgatatg 2246221 tttcttattg acaccaaacc agcctttttt ccgatcaagc catctgcttt ccacaaggag 2246281 agcgaggaga aatctcgata agaaaacggc agtgataaag cttgtcaaaa tcgataggat 2246341 cagcattgtc gcaaaccctt taacagagct tgtcccaaag ataaagagca caaccgctgc 2246401 aataatggtt gtaatattcg cgtcaaaaat cgtcgcaaat gaccgtctgt ttcctgaacg 2246461 gaaggcagag cggactgact ttcctagctt gagctcttct ttaatccgct cataggtaat 2246521 aatgttggcg tcaacagcca tcccgacacc taaaatgaga gcggcaattc ccggaagcgt 2246581 gagtacggca ttcatccagt caaagatctg gagtgtaatg tagatataaa cagacagcgt 2246641 aatcaccgcg attaatcccg gcagacggta atagaaaagc ataaataaga aaataattgc 2246701 gataccgaca ataccggcaa acaccgtatc atggagagcc tgctggccga attgcgcgcc 2246761 tactgatgtc gaatactttt cagtcagttt cacaggaagt gcgcctgcgt ttaaaatgct 2246821 ggctaaatct ttcgcttctt gagctgtgaa atgaccttca atttttacat cagttgtatt 2246881 tagttcctga cttacatttg gagcggatac aaatttagga tgctcttttt gaacttcttt 2246941 cttaaaggaa tcacctttat cataatccaa ccaaatgaca agctggttgt ttggcgccat 2247001 tttcatgacc ttcttggtca cttcaccaaa tttatcagcg tctttcagct taatcgtgac 2247061 aattggctca tttgttgtgc tatcataagt ttgtttagcg ccgttttcga ctagatcagc 2247121 accgtttaac agttccttat catttgcatc tctgaaagaa agctgcgctt cagtcgccaa 2247181 aatttcacgc gctctgtttt ggtttgtcac gccagcgagc tgaacgcgaa tccggttatt 2247241 cccttcaatt tggatgttcg gttcgctgac accgagaaca ttggcccggc ggttcagtgc 2247301 ctctactgtg ctgaccagaa cgtcttttgt gattttgtca ccttttttta caggctgtac 2247361 atcatacagc acctcaaatc cgccttgcaa atccaatcct aacgtaatat tgttagcggc 2247421 aggcttcgta aagtagccca agcccgtgcc gatcaataga acgaaaagga aaaacgcaat 2247481 caagcgtcct tttttcatta tgtatatcct cccttaaacc tgtgcgaatc aacctgctat 2247541 ctcagcagtt cttccaatgc ttcctggccc tcttcactgc ccagccaatt agacgtttta 2247601 aatgactcaa cggttgcata gttcataaat tcgccaattt tcactgataa aatatcactc 2247661 gccagttcat aaatgctcag ttccgttttc tttttccact tcttatctgt taagtatgac 2247721 cacaaacttt cgagttcaac atcatcatac ccgagaatct taaactcttc cagtttgctg 2247781 taaagaaacg gcctgacgtg gtctttatat agatcggctg gatgcttctc cacgaattcc 2247841 acgctccttt tttattgttt ttcaagaaga cttgtcatgc ttggacgaca tatacgcata 2247901 tctttattgt atatgattcc aggtagtttg agaaggcagg gggtaaaaat ggcgaaacag 2247961 acgtttttaa agggcactct tatccttatc gcagcaggaa tggttacaag aatgctcggg 2248021 tttgtcaacc gggtggttat cgcccgtttt atcggtgaag aaggagtcgg gctttacatg 2248081 atggcagcgc ctactttctt cttggccact acattaactc aattcggtct gccggtcgcg 2248141 atcagcaagc tagtcgctga agccagtgcg cgcggagatc atcaaaaaac gaaaaatatt 2248201 ttagtcatgt ctctgaccat tacgggagtg ctcagcctca tctttacacc gctgtttctg 2248261 tttttcgccc ctgttatggc tgaaacgatg ctgacagata agcgaacact gtatccgctc 2248321 ttggccatta cgcctgttgt gccgattatt gctatatcga gtgtgctgag gggatacttt 2248381 caaggaaaac agaatatgaa cccgcttgct atgtcacaag tccttgaaca ggttgtccgc 2248441 atttcactcg tggctgtctg cacaacgatt tttctccctt acggaattga atatgctgca 2248501 gcgggggcaa tgctatcctc agtggcaggg gagctggcat cacttcttta tttattcgtt 2248561 tgctttaagt ataaaaagac aattaaaatc agaaagcatt ttttacagtc aattaaaaac 2248621 ggaaaacaaa cctttaccca attaatgagc gtgtcccttc caacaaccgg gagccgcttt 2248681 atcggaaacc tctcttggtt tttcgagcca atcgtcgtcg ctcaaagcct tgccatcgcc 2248741 ggtgtggcaa cagttgccgc aacaaagcaa tacggggaac taaccggctt tgccatgacg 2248801 ctgctgactc tgcccagctt tattacatat tctttgtcga ccgcgcttgt tcctgcgatc 2248861 agtgaaggaa tggagcagaa aaaattgcag gtggtggaat accgcttaga acaggcgatg 2248921 cgtctctgtc tgctcagcgg aggcatttca gttgttattt tatttgtatt tgcggatgag 2248981 ctgatgagag tgatgtacgg ttcctcaggc gcagctgtat ttataaaagt gatggccccg 2249041 ttttttctgc tttattattt ccaaggcccg cttcaagctg tgctgcaggc gcttaatttg 2249101 gcaggagctg cgatgatgaa cagcttaatc ggagcgcttg tcaaaacagg ccttattttt 2249161 gtccttgcca caaggccttc tcttggcatt atgggcgcgg cattagccat tgtgacaggc 2249221 atggtgctcg tcacgctatt gcacgcagca accgtaagca aagtgctgcc gatcagcatc 2249281 aaaatcaagg agtacgcgct cagcttcgct gttattgtaa tttgcggatt catcagctcc 2249341 gccatcaaac aatatataag ctttggagca tctgaggctg tcaatctagc cggatggatt 2249401 gcggcgagcg ccgccattta tatgatcctc ctgctcgttt tccgtttaat taaaaaagat 2249461 gagcttcgcc gcattcccat tatcggacgg ttgatcatcc gataatggtc acgtgcggtg 2249521 cccatctttt tcatcaatat atatttctcc gtctgtaaac gagcaaaatg aaatatctga 2249581 agggtttgtg tatccgtgtt tttgcaaact ttcaagcagc cattttctat ctttactgat 2249641 tctggacagg ttttctgttt gaatgaagcc gtctataatg agcggcattt cgagctgccg 2249701 atgctctccg ctgttttctt tcttaacaat agtcagtttg cccgacggct ctaaaatagc 2249761 aaatgatacg tcagctactc tgtcgatgct attttctctg agctgaacca ttaaatcatc 2249821 aaaattataa cgctgtgatt tcatggcttc ttcgtcaatt tttccatatt tgataattat 2249881 ggtcggctta ccgtcaagaa gctggcggac ttttcggttt tttaaagaaa agtatgccaa 2249941 agtcacttga atgatcatta atacaagcat tggcaaaatg gtatgaaata gatgatcgtc 2250001 tacgttttct atggctaaaa cggcaatttc agccatcatg ataaagacaa cgagatctaa 2250061 aatactaagc tctccgatct cccgtttgcc catgaaacga aaaatgacca atatcacaaa 2250121 atacaatacg actgtgcgaa acgcaatagt gagaagctct tccattatgc acctccaact 2250181 cattataggt tgcaacaaaa tgatcaattt atgtaagaaa aaccgattgc atttcacaaa 2250241 gcttttacgt ctaattcatg ggataaggga atacattttt acaaagacga gccatcagca 2250301 tgtctgacgg ttttgaacaa aaagaacaga agccttttaa tacaggcaga gaggagacaa 2250361 tcatggagga aacgaaacaa gttggaaaag gcattcttta cggcttaatc gccatatttt 2250421 cagccatgct cctgacaagt ttagcggttt cacttttatt gaccgcaacc tcgctggaag 2250481 aatcatcatt taactggctg atcaccgcta tctcatttct ctctttattt atcggcgggt 2250541 tcatttcagg cgggaaaggc aaggaaagag gctggatgat tggcgcattg accgccttaa 2250601 gtttttctct gattatctta ttgtttcagt atttaggatt cggaaagaca tttacagcag 2250661 aacagctgat cttccatctg ggatttttag gggtgtgcat gctgggcggg attttcggcg 2250721 tgaacatgag gggaaacagg tcttccacat aaaaaagagc gggctcactt gcccgctctt 2250781 ttttgtttgc tatgtatagc tcctgctgtt attcagcagc agaaacttct ctgatcgcgc 2250841 ggcggtcgaa cgtaagacgt gtgttatcac cagtcttaat tacgactttg ctttcgtcga 2250901 tagagtcaac agtaccgtgc aatcccccga ttgtcactac tgaatcgcct tttttcagtt 2250961 cctcttgcat ttggcgtaca gccttttgct gcttttgctg aggacgaatc agcaagaagt 2251021 aaaggaccgc aaacattaaa ataataggaa ccaatgtacc taaagtgcca gtcatcattt 2251081 tcaccccttt ctgtaagcct gttatgttta tttagaagct tttcgcattt ggcttgttat 2251141 agccgtaacg ctcaaagaac tcttctctga aatcacccag acgatcctcg cgaatagcct 2251201 gtcttacctg ctccattaag tgtaacagaa aatgaaggtt atggtaagtt gttaatcgaa 2251261 ggccgaatgt ttcattgcag cgaatcaagt gcctaatgta cgcgcgagtg tagtttttac 2251321 atgtatagca atcacactct tcatcaatcg gacggaagtc tctttcaaat ttcgcatttt 2251381 tcatattgag tcgtccttca gcagtaaaca ctgtgccgtt tcttgcaatc cgtgtaggca 2251441 gcacacagtc aaacatatcg accccgcgga tcgctccgtc gatcagtgcg tccggagaac 2251501 ctactcccat cagatatctc ggtttatcct tcggcaagag cggtgttgtg aattcgagta 2251561 cacggttcat gacatccttc ggttcaccta cagacaatcc gcctatagca tatcccggaa 2251621 aatcaagcga aatcaagtcc ttcgcacttt gtgtccgcag atcttcatat tctccgcctt 2251681 gtacaatacc aaacagccct tgttcatcct gacgattgtg ggcattcagg cagcgttccg 2251741 cccagcggct tgtccgttca actgacctct tcatgtagtc gtactccgcc gggtatggcg 2251801 ggcattcgtc aaacgccatc ataatatcag agccgagtgc gttttggatc tccatcgctt 2251861 tttccggaga taaaaacagc ttgtctccat ttagatgatt gcggaaatgg acaccctctt 2251921 cctctatatt acgaaacttg cttaaagaaa agacctgaaa accgcctgaa tctgttaaaa 2251981 ttgcgcggtc ccagttcata aatttatgga gcccgcccgc ttctttgaca atgtcttggc 2252041 ccggacgaag ccatagatga taagtgttgc tcaaaatgat gcctgcatcc attgctttca 2252101 gctcttcagg cgacattgtt ttgactgtcg ccagtgtgcc gaccggcata aaaaccggcg 2252161 tttcgaagga gccgtgaggc gtatgcactt tgcccagccg cgctcctgtt tgtttgcatt 2252221 cttttataaa ttcatagcgt attggttgtt cagccacttt tgatgaggcc tcctgttctc 2252281 aaattatata atcagcatcg cgtctccgaa gctgaagaaa cggtattcct cttccactgc 2252341 atggttatag gcacgcagaa tgttttctct tccagcaagc gcgctgacca gcataatcaa 2252401 tgacgatttc ggcaaatgga agtttgtaat cattccgtca atggctttaa attcatagcc 2252461 cggataaata aaaatagatg tccagccgct tgatgcttta aattgcccgt catgttctcc 2252521 ggcaatcgtc tcaagcgtgc gtgtcgaggt cgtgccgaca gaaatgatcc gaccgccatt 2252581 ttctcttact ttgtttaagg ctgcagccgt ttcttctgac atttgataaa actctgcatg 2252641 catattatgc tcttccactt catcggcact cacagggcga aacgttccaa ggcctacgtg 2252701 cagtgtgatg aactcaattt gcacgccttt gtctttcagc tgctgtaaga tttcttccgt 2252761 gaagtgaagg ccagctgtag gcgcagcagc agagccaatt tcttttgaat acactgtctg 2252821 gtagcgctct ttgtcatcaa gctgttcttt gatatatgga gggagcggca tctctccaag 2252881 ggattcaagc acctcgtaga aaataccgtc atattgaaat tccatctttc tgccgccgtg 2252941 ctcaagctct tccgtgcaga ttgccttcaa tcttccgtct ccaaatgtga caacagttcc 2253001 ttttttcacc cgtttcgccg gtttggcaag tgtttcccat ttatcaccgg tttcctgttt 2253061 caacaaaaga agttccactt tcgcgccggt atcctctttt gtgccgaata accgcgcagg 2253121 cagtacccgg gtattgttca ggactagaca atcgccttcg ttaaagaagc tgataatgtg 2253181 tttaaacgag ctgtcagtaa gctctcctgt atgtttatcg agcaccatca gccttgaagc 2253241 atcacgctgc tccaacggta cttgtgcaat taaacgttct ggtagttcaa aatcaaataa 2253301 atcgactttc atgatgattt cacctttatt ctagtctttt gttatttcat tctgccaaaa 2253361 agattaagca aaattgataa taccacactt ataataatac aagtgacaac cgggaagaaa 2253421 aacgtaacat ttcctttttt tacaaaaata tctcccggca tcttgccgac aaaatgcaaa 2253481 actgctccga taataagcaa aacagcacca agaatcataa tgatcttagg aaattcagtc 2253541 atatcgggga gcctccattt ggaaatgatg ataaacggcc ggtgtcacga tccttccacg 2253601 cggcgttctt tgtataaatc caatttgcag cagatatggt tcatatacgt cttcaatcgt 2253661 atgcgattcc tcgccgatgg tagctgaaat cgtatcaagg cctactgggc cgccgttgaa 2253721 tttttcgatc atgcccatca gcagcttatg atcaatatga tccaaaccga ggcggtcaac 2253781 ctgaagccgc tccagcgcat tctgagaaat gtcttccgta atcctgctgt cacccagcac 2253841 ttgggcgaaa tcgcgcaccc ttctcagcag gcggttcgcc acgcggggcg tccctctcga 2253901 tcttcttgca atttcaagag ccgacggttt atcaatctca acctcgaata catcagcggt 2253961 tcttgtgaca atatccgcca gttcttcttg tgtatagtac tcaaggcgag acattacgcc 2254021 gaatctgtct cttaaaggag ccgtcaaaag ccccaccctc gtcgtggctc ccaccagcgt 2254081 aaaaggcgga aggtcgaggc gaaccgagcg ggcagatggg cctttgccaa tcacaatgtc 2254141 caggcaaaag tcttccattg caggataaag cacctcttcg atcgatctgt gcagcctatg 2254201 tatttcatca ataaataata catctcccgg ttccagcgcc gttaatatag cagccaaatc 2254261 accaggcctt tcaatcgcag gccctgatgt cgtccgcaat tccactccca tttcattagc 2254321 aacaatcgaa gcaagcgttg tttttccgag tccgggcggc ccgtacagaa gaacatgatc 2254381 cagcgtctcc tgtctcattt tcgccgcatc tataaacacg cgcaaatttt cttttacctt 2254441 atgctgcccg atatactgtg ccagattttg cggcctcagg ctttgctcta tcactgattc 2254501 atggttgtct gcttcacttg agacgagccg ttcatccatg aacatcacct tactttaata 2254561 gtttttgtaa tgcttttttc acatattggt ctgttgtcag cccaatttct tctttaaggt 2254621 gaggaagcac ctttttgatt tctttttcag catatccgag aaccctgagg gcttcaagtg 2254681 cttcttcaag agccgtttcc gctgtttgct tttcaagcct ttcttcatga ttaaacagat 2254741 tttcaatcat ttcaggcaca acatctgcca gctttccttt taaatctaga ataatctggc 2254801 gtgcggtttt ctttcctact ccaggaaact tgaccaaaaa agcttcatct tcattttcaa 2254861 ttgcttggat gaccgctccg ggatcacccg agcccaagat ggcaagtgct cctttcgggc 2254921 caattccggt cacgtttaac agctttgtaa agagcgcctt ctcctctctt gttgaaaaac 2254981 cataaagcga aaaagcatcc tctctgatat gatggtatgt aaaaatcgtt tcttggcttc 2255041 tctccttata tataaacgga ttcggcgtga aaatctgata gccgatgccg ccgttctcta 2255101 tgacaatata ttggggagat acataatcaa tcgtcccttt aacaaattca atcacgcaaa 2255161 ttcacctctt tgactgttct tcattgtacc ataaaaacag ccaaagtctt atagaaaagt 2255221 taacatatgt tcgcttctct ctcattcttt cacgaaaaaa aagacatgaa tacatgtctt 2255281 caatcagcgg acgctacccg ctgtatgtct tcatatgttc gatgacatcc tcaaactccg 2255341 cttttgtccg aaatggaatg cctttcagca gatttttttg catatggctt tccagccttt 2255401 ctaaatcaat ttgaaaaaaa gactgaattg gttcggaagc tggctcaggc cgcccatgaa 2255461 aagtggaaat cactccatta tccgatacac cgatataccc gttgaccttg ctgagcggag 2255521 aaatatcgtc catttgcttc cggaagagca catatccctt tttttgttcc actagcgtcc 2255581 atccggcata agctgcccaa aaatcatcca tagaaaacac tttttcatgc ttatgctcaa 2255641 tgctgacatc gccgtccaaa tacacctttt caagctgcac atgcacctgc agcggctcat 2255701 agtgctccac ttccgcgcca agtgcgcggg aaggagctcc tattaaaaat actgccgctg 2255761 agcaaagaat gcccagcaaa agatacgccg tgctgaatcg tttcaccctc tacacctctt 2255821 tgcacacgtt tatgattagt ttgaccaaag aggctactgc ttaaccgttt tatcaaaatt 2255881 tgtctgcaca ttttccctga caaaccgttc ctccgtatac acatctgtgc tttgctcaga 2255941 aattgtcaag aatcgcgtca gaaaggcact gaaaaaatac aatgccgcaa agatccaaat 2256001 cacgccacct gcaccgagcg gcccaatgaa aagactcacg atgcccggcg cgataaacgc 2256061 acataaacca gatcccaaat tcaacactga catggcagca cctttattat caggtgcaag 2256121 cgtcggcaaa agcgcgctta atgggacgta ccctgctaaa gccgcgccgt agcagcaggc 2256181 gataatcatg agcacccaat actgatgccc gatcagctga ggcgtgtaat acagcgccag 2256241 cgtaaaaata ccgcatccga caccgccaaa ccacatgacc gtattgcgcc agcctagttt 2256301 atctccgact gcaccgaaaa tgatattaaa cacaatattc acaaaaaaca gcgtccccca 2256361 tatttgcagc cattccgaaa ccgaataccc gtatcgtgct aaataagtag gaagaaagat 2256421 ggcaaatcca aattgtccta tcgcattaat cgtcttgacc actccgccga tgcctacctt 2256481 agggttttca aacataatcg taaatgcctt cgacagttct ttccatttcg gctgatcttg 2256541 tttttgtatc ggagtaaatt tatctttgtt aaaaaataag gcaagaattc cgcctgccgc 2256601 cacaaacagt aaagcgctcc aaagcgtatt gatttctcca aaggccggaa ctgcatagct 2256661 ggaatagaac ggaccgagca cgttaaggcc gcacgtaaac ataaaccaaa accagccgac 2256721 ggcttttcca agaatatttt gagaggtgct gtatgacacc catacgagaa aagagtatgc 2256781 aaacagcgga tatcccaagc ctctaagagc atagctgccc aagagagccg gataatacat 2256841 atgaggaatc gcccagccga taaaagcggc cgaaccgagg ataaatgcaa gcaatccgac 2256901 agtcatcgtt tttctcggcc cccaagtttg gacaaacgtt cctgaaagcc aagctgagat 2256961 ggtgacagca atgccgtaca tggtaaataa cgatgcggat tgctgcatac tgagaccatg 2257021 atcaacgaga aaaggagaca gccagccttg ttcgaggccg tctccaacca taaagatgac 2257081 aacgccaata taaccccaaa ccatgtgaga aggaattccg attttgttca aaacatttcc 2257141 tttagcatgt actgtattca ttttctccac cgcctactta aagtatcaat ggagtatata 2257201 cccaagcttg ctgaattgta atcctgttag attaaaaagc gattttttca gtgtgctcaa 2257261 tgctaacagg catgccaaaa gcaagcgatt gctgtgctgc tctggcgatc ctcccggcct 2257321 gtaaaccgtc attgccggtg cagggagtct cctggtttgt gccgatcgct tctgcaaaac 2257381 ggagaatctc ctcctcatat gaatccttat agcgttcaag gaaaaagaaa tgcggtttat 2257441 ccttcatcac aaaatcagct gttgacacct caaccgttgt cggcctgcta ttgtcagccg 2257501 ctgcagagcc tttcgtcccg aaaacctcaa cccgctggtc atatccgtac acagcttggc 2257561 ggctgttatc aatcacagcc atggcaccgt tttcaaaagt cagtgtaata acagctgtat 2257621 caatatcacc cagctccgca aaagaaggat tcaccaaagc cgcccctttg gcatacactt 2257681 ccgtcacttc gcttcccata atatatctgg ccatatcaaa atcatggatc gacatatcca 2257741 taaacaatcc gcctgacgta cggacataat ctatattcgg gggttctggg tcccgggacg 2257801 tgatttttaa taaatgaggt gtaccgattt caccattttc aacaatcgtt ttgattttct 2257861 taaaatgagg atcaaagcgg cggttaaatc cgacttgaag tgttaccccg tgtttccgga 2257921 cagccgcaag cgcttcactc gtttcgtcca gagagaaact aacgggcttc tcacaaaata 2257981 tatgcttttt cgcctcggct gcttctttga tcatctgtgc atgtacggct gtaggagagc 2258041 aaataaaaat agcatcaata tcaggatcat gtaataaatc acgataatca gaggttatgt 2258101 attcaatctg atgactgtcg gcccagcttt ttatacggct cgcctgaatg tcagagattg 2258161 cttttatttt catgtgagga atccggctta tattttgaac atgaagtttg ccgatgcggc 2258221 ctgcaccgat aatccctgtc acaatctgtt ttgtcatggc ttcttccccc ttgatcattc 2258281 acgaaagcgc tttatttaaa attaatacta tcccatttgt aagcgctttt caagaatgga 2258341 aattaaacgt tctatgtctc ttttatcaca attcatgctt ataagtagcc ttcttcttca 2258401 agaccagata cactagaatt aggctctttt tcctgaacag tttatgattt tcctataaac 2258461 agctgcataa aatagagcaa agaaggtgaa tgaaatgctg acaaaagcag aggcactggc 2258521 ccataccgtc atataccgca agaacagcag atttgataaa gtcaaagaga aatccgagga 2258581 attaacacta atcggcaagg gaagaagcgc ctatgtgttt gccttaacag aaggcggtcg 2258641 aaaaatggcg ctgaaagtat tttttccgga atatcaagcg acagcagtca aagaagcagc 2258701 gatctatgaa aaattagccg ggtccgcatt ctatcctgac atttacgaaa ctggcgattc 2258761 atttattctc atggaatata ttaaaggtga aaccttttat aactgtctga agaaaggcat 2258821 tgcaatcagt gatgacatga ttcagcaggt tgaagaagcg ctttctgacg cccgggcagc 2258881 cggactgaac ccgtcagata ttcatttgcg gaatctgata ttgacagaaa ccggggcggt 2258941 gcgggtgatt gatgttgcga gatttgagca gacaaaaaca tgcacgcagt gggacgactt 2259001 aaaatccgca tatcatgcac tctacaaaaa accgatattc cccaaaaaga ttccgggttt 2259061 ttggctggag atcatcgcat ttttatataa gaaagattgg tttcaaaagc atttcgcaca 2259121 gcggaaaaga aaatattctt aaatcaaaaa ggcagccgca caagcggctg cctttatcat 2259181 gtatttttta ctttctgacg gcagaaatca gtttcatttg ttcaggcgac agcttaattc 2259241 gatagcctct cacagttaag tagaccgctt ctgggtcctt ctcgccggaa tgacaatacg 2259301 ttttttccat ttctgtctcc cctcaccctt tattggcttt atttcatctt atcattgctt 2259361 tattgaggta attttaaaga aatgtaaaga ttatatgaat ccgatatata gtaaaatgag 2259421 agaaaaaaag ggagagagtc acattaagac cgaaaacacc ttgagcttag atgcagccag 2259481 aggtgaactt gtaaatgaaa aaacacttgt caagagaaca atctactgga attacccgga 2259541 cagccgccca gcagtgacgt ggatcaatca caatacagtg aaaatcggca atcagacttt 2259601 acatcttgat actgatgaaa cgtatgattg gcgaaaagat gatcattgga tccgtgaaga 2259661 accgccgcag gcgtcagtga ggtgatgaaa catgaataag atgaacggaa caaatgatga 2259721 aaagcatttc aatcattttg tgattgcttt atcctttata tacggtttga ctgaactagg 2259781 ctatttgttg ctgaaggatt ttataacaat tgccataagt ttgcctctgt agaaaaacgc 2259841 agcgtagtcg atacgccgcg ttttttcttt ttcccttcct cttcttattg ataattacag 2259901 gtcatataat gtgacaaatc gattgtagaa atagttcgat tagaccaaaa tcctttttat 2259961 acatgtattc gaatttgaag tgagggggaa gcttgatggc agattttgtt gctagtttga 2260021 atgcggtctt atggagtacg cccgtcattt atattttatt gggaattgga ttcgcctttt 2260081 caattatgac ccgtttttta caagtccgac atttaaaaga aatgattgtt cagatgttca 2260141 aaggcaagag ctctgaagcc ggcgtttcat ctttccaagc gttatcgatt gcgctgtccg 2260201 gccgtgtggg cacaggaaac atcgcgggag tggcgacagc aattgcattc ggcggacccg 2260261 gtgcagtgtt ctggatgtgg gcgattgcct ttatcggggc ggcgagtgcc tttgtagaat 2260321 caacgcttgc tcaaatttac aaagtgaaac aagacggtca atatcggggc ggccctgctt 2260381 attatataga aaaaggctta ggcattaagt ggtttgccgt cttatttgcc gctgctgccc 2260441 ttattgcaat ggcctttcta atgccgggcg tacagtccaa ctccattgcg gctgggatcc 2260501 aaaatgcatt cggcatctct cctttcgtca cagggtgcgg tctggtttta ttattagggt 2260561 tcattatttt tggcggcgtc aaacgaattg ccaatgcggc gcaaatgatt gttccattta 2260621 tggccattgg atatatcctg ctgtctttga ttattattgt catgaatgtg tctgaattgc 2260681 ctgctgtgat ctcattaata ttcaaaagcg ccttcgcatt ggattccgct tttggcggct 2260741 tgatcggtat ggcgatttcc tggggcgtta aacgtggcat ttactcaaac gaagccggcc 2260801 agggaacagg cccgcatccg gcagctgctg cagaggtttc tcatccggtc aagcagggac 2260861 tggttcaggc attttctgtt tatattgaca ccttgtttgt atgttccgct acagctttca 2260921 tgatcttgtt taccggcatg tacaataccc aggctgcaga tggttccttt atcgttcacc 2260981 agcttaaagg cgtagaagca ggacctggtt tcacacaagc ggcaattgac agtgttcttc 2261041 ccggattcgg tgcaggcttt gttgccatcg ctttattctt cttcgctttt acaacaatta 2261101 tggcgtatta ctacatcgca gaaacaaata tcgcctattt agcacgaggc agagaaagca 2261161 aatgggcgat gcttggctta aaactgatta ttttagccgc cacgttctat ggtactgtga 2261221 aaacagcttc acttgcttgg gcattagggg atgcagggct tggcattatg gtatggctga 2261281 acgtcattgc cattgtgctg cttgccaagc cggcgctcct tgctttaaag gattatgagc 2261341 gccaaaagaa gcagggctta gacccgatct ttgatccaaa agcgctgggt atcaaaaacg 2261401 ctgatttctg ggagaaagaa tacactcatg aaagtgaacg tgtctcctga acatactaaa 2261461 accggcccga tatgacctcg tgccggtttt ttatgaacga tagtttgtat acacttcttg 2261521 aacatcatcg tcatcttcaa ggacgtctat taatgtttcc agcttctcaa cagcctgatc 2261581 atcggcttct gcataggtat tgggaagcat ggtcacctcc gccgaagaaa ttagatattt 2261641 cgattcgagg gctgttttca cctcttcaaa atgctcaggc tctgtgaaaa cctcatatag 2261701 gtcttcttca attcgcagct cttctcctcc tgcttcaagc acatcaagca tgagctcatc 2261761 ttcttctatt tgccgttcag tacggtctat cgtaatgaac ccctttcgtt caaataaaaa 2261821 ggctacacat ccgctttctc ccagacttcc gccattttta ttaaaggctg tccgcacatt 2261881 tgacgccgtt cggtttttat tatctgttac gcattcaacc atgacggcaa tccctgaagg 2261941 gccgtagcct tcataggtga tttcttcata gctgcttccg tcttggcctc ccgcagcttt 2262001 tttaatggcc cgatctatat tttcattcgg catattggcg ccttttgctt tttcgatgac 2262061 aagacgcaat gctgaatttg cttctggatc cgctccgcct tctttcgctg ccacatagat 2262121 ttcttttgcc agcttcataa atattttccc gcgctttgca tcctgtgcat tttttctttt 2262181 ttgaatgttt ttccacttgg aatggcctgc catgttttca ccttctttta cattttctat 2262241 gtacacttta atgggaaatg ttcgctgatg caaagaaaaa ggctgccgaa tatcacttcc 2262301 ggcagccctt ccttcctagc ggttgttcat tttatgaagt tttctgaaca gccctttatc 2262361 tgttgatact tggacgtcac ggccatttgc atagttgcgc gctgctttta caacattatc 2262421 tctgtcagac tttgtgaact ctctgtggct tttgactgcg ataactactc ggtcatccga 2262481 taccataact tgtgtgtcat tgacgttttt cacttgtttc acacggttgg caatttttgc 2262541 agccagtctt ctgttttctt ggttgtcata cccgttgttc gctgcattcc gattcatgtt 2262601 tcggttattc gtgttgttat atgttccgtc agttgccaaa ggaacacgat cgtcagcagt 2262661 aacacggtca cggttattta cattcgtggt gtttcggtta ccgtcgttct gatcctccat 2262721 taattcagaa acaggaccat cgtggtcgat tccgtctccc tgtctatcgg cgtcattttc 2262781 atttgtataa tatccgattg gacgggtatt gccgttattg cgcgtatcat tcatagcatt 2262841 atcgtttgct ccgcatgctg ttaagccggc tgtcattaga atcaggctag cgatcgtcat 2262901 ttttttaccc aatggaaaaa ccccccgtgg acgaattgag catgtttgct cgcttttatc 2262961 atgtgcgtat ggggggcatg ttaagcgtgt cagttctctc catttggcag tgatctgctt 2263021 gaaaacaaaa aaaggaacga tttacatcgt tccgaacgat cactcatttt cttcttccgg 2263081 acggccaaac atttggttta cagaaggctg gttcgtcatt ggcatagaaa ctcctgccga 2263141 atatgggttt ggatttgggt tagctgtgcc atatggcata ttagggcttc cataagctcc 2263201 cattcccgaa tggccaggtg cagagaaata tggctgatga tcaccgtcac agccgcagtc 2263261 gtcatgatct ttgtatggca tgtaaccatg agccgcagca ggctggtatg ctcccattac 2263321 ttggggagtg ccgtaataag ggccatacgg catatgtcca tacggagatc cataagccgg 2263381 agatgcgtat tgcggcgcac cgtatgaacc gtaatgtccg tgatggctgt tttcatgatg 2263441 ctggttttca taacccgggt catactgagg cgatacaaag cctggctggt atccatgcat 2263501 cggatgcatt ggataagctt gtgccggata gtacggatag cataatcctg atcctggaag 2263561 aattggcgaa acaggcaccg gacacggtac gaaatgagcc ggataatgat aataaggctg 2263621 aacagccggc atcggcatat tcggaactgt gtgatgaacg ttttcctctt ctataccgcc 2263681 tacctctggc gcctttggca tattaggcat attcggataa tttgcatttt ccatattact 2263741 catagcctcc tgttgtggaa attggtcttg catatgatac atatgatcca tatttccgtc 2263801 atgatgtttt ttcggctcct ccggtttagg aggcgaccaa ggctggaaaa gctgtttcat 2263861 atcataataa tcgttcacat cagcttcagg gtacacattt tcctgcaaat taggcatcgg 2263921 cgggacatac ggcatggact tcttttcttt cggctttgtg tcttctacat cgacaacgga 2263981 tttaggcttc tctttcgcat atggatgttc ttgcttcaca ctcccggccg caggactttt 2264041 gcccgctttt ggctcttttc tgaccgggac tccttctgac ggcactttta ttttcattcc 2264101 aggcatgatt aagtctggat tgctaagctg tgtattgagt tttttcactt cctcaacatc 2264161 gactccgtac ttttcagcta ttttccagag cgaatcgcct ttttgaacga tatggatttt 2264221 caacgttttc ccctcctatg caaaacgtga acagttcagc tgtgattaca atatgtttct 2264281 tcacaacata tgcctgaaca aaagaagtta tgagtaaagg aagggaaaat atttctgatc 2264341 tacgtgatcg aaagcattcg attcagggca aggagtgcat cttcctgaat ggcttttggc 2264401 accttgatga cgcctgaagg ttctcctttt tcaatttgtt ccagcgacca caacaaatgc 2264461 ggcaaatcaa ttcggttcat tgtcaggcaa gggcacatgt cagggttgag tgattcgatt 2264521 tgtttatctg gatgctcgtg aatgatccgc tgaacaagat tcatttctgt cccgattgcc 2264581 cacttgcttc ccgccggagc ctggttgatt gtgtcgataa tatatttcgt tgatccgtta 2264641 tcatcgctta gtgtcacgac ttcgtgtgaa cattccgggt gcacaatgat ctgaatgtcg 2264701 gggtctcgct ctctcatatc atggatattt ttagtggtga atttctcgtg aacagagcaa 2264761 tgccctttcc acaaaatcac tttcacattc gtatgcccgg attcagctac taattcatct 2264821 ttcatcggat cccacacagc catatcttca agcgcaatgc ccagatcata agccgtattt 2264881 ctccctaaat gctgatcagg caaaaataaa attctttttt tctgtgtaaa cgcccattca 2264941 agcacttttt tcgcattcga agaagttaca gttgctccgc catgctttcc gacgaatgcc 2265001 ttgatctccg cagtggagtt cacataagtt aaaggtatga tcgtatctcc aaatatatgc 2265061 tgaagcttct tccatgccct attggtctgc tgcatgtcag ccatgtcagc catagaacat 2265121 ccagctctca tatctggcag gacgaccgtt tgctgctcgc ttgtcagcat atcggcggtt 2265181 tctgccataa agtgaacgcc gcaaaatacg atataatccg cttctttgtt tttttccgct 2265241 acttgggcca attgcaggga gtcgcctgtt tggtcagcaa attgtatcac ttcatccttt 2265301 tgataatgat ggcctggtat aaagagcctg ctgccgaact ttttcttaat ggcggcaacg 2265361 cgcgtttcca tatcctttct cgatagttct ttataacttt cgggcatcat atcattcgat 2265421 tgtttgatca catcaagaat tgacataaca gcattcctcc acagattcat ttgataacgt 2265481 aacatccatg ctgatatcta aacttttgac ggaatgagtc agaaatccta atgaaatata 2265541 attcacaccc gtccctttaa aagcaggcaa agattctaac gtaatcccgc cagaggcttc 2265601 agtttttata ttagccggtg tgagctttgc aaaatgacgg accgtatcag gcggacagtt 2265661 gtcaaacata ataacatccg ctccagctgc aattgcttcc cgcagctgtt cctccgtttc 2265721 aatttccacc tcgatattta ccatgtgccc tgcggcctga cgggcttttt tgcacgcctc 2265781 taaaatagag ccgcatgctg cgatatgatt atctttaatc atgatgccgt catacaaacc 2265841 gaatcgatga ttatacccgc cgccggctct gacagcatat ttctccagca ttctgagccc 2265901 cggtgttgtt tttctcgtgt cacaaatttt aatctgttca tcatccagac accgaacagc 2265961 ctctcttgtc attgtcgcaa ttcctgacag cctctgaata agatttaata cgacccgctc 2266021 tcctgaaagg agcgcagctg cgggaccgtg taactcggca atcacttcac ctttatgcaa 2266081 catgtcccca tcttttttgt gtaaaatgct ttgaacattt tcgtccaata acgaaaagcc 2266141 ttcttttatg atcgctgctc ctgcaaaaat accctctgac tttgcaacaa tctccgcttc 2266201 acagctctgt tctccaaaaa tagactgcga tgtaagatcc cctgtcccaa tatcctcaag 2266261 aaaaaagtga ttcagtaatt ttttcagctg taaatgattc attgttccaa atcccctcgt 2266321 tttttctgat cttcgttcct ttttttgtat ggacaatttg tcttccttgc cagctcacct 2266381 cagcatgagg aaaatcggtg cggaagtgag cccctctgct ttcctcccgc aaaagcgcag 2266441 aaaacgtcat cagctttgca gtttgccata gatgagaaag ttccatctgc cgaattgtga 2266501 tatccttcac atttacttcc tgaaaaggca gcgtatgaag ccagatgcta agctcaatca 2266561 aactgctttg ttcccgcaga atagacatgt ggcttgtcat tttgctttgc agttcatgcc 2266621 cctctatatc cggcacctcg tagaagacac tggtttctag ccctgattga tattgcctgt 2266681 tataaaccgg tttttggata atatgctctg ctgccctttt tccaaatacc agcgcttcca 2266741 ataaagaatt gcttgcaagc cggtttgctc catgtaaacc ggagcatgct gtctcgccaa 2266801 tcgcataaag ccccggcact gtcgtttctc cccagcgatt aactgaaaca cctcccatta 2266861 agaaatgcat tcccggagca acaggaattt ttccgctgtg gatatcaatc cctgcttttt 2266921 cacaaatagc ggtgatggta gggaaacgcg tttcaaaatc agaaatcgca ctgaagtcta 2266981 tataaacgcg atttcctttt gccatttctt cgtgaataac ccgtgagaca atatctcttg 2267041 gagccaggtc acctaaagga tgccgttcag ccataatcct gcggccgttt tcgtctacta 2267101 aacatccgcc ttcccctctg acagcttctg aaacaagccc gtaggaaaca ccatttttca 2267161 caagcagtgt cgggtgaaac tgagtaaact ccaaatccgt taattccgcc ccggcccggt 2267221 aagccagaga aagaccgtca cctgtgacag tgagatcatt cgtatggtga agaaacaggt 2267281 ttccacagcc gccggcagcc agcacaactt cgtctgcgtg ccttaccttg agccgccctt 2267341 tgctgtcttt tgtcatgacg ccgatacatc gtccgtcctc tataagcaaa tctgctgccg 2267401 tttcattctc gattaacttg attttgctgt tgatccgttt gagcaaataa tcgataagca 2267461 gcctgcctgt tgcgtctccg cctgcatgaa atatgcggtt gtatgagtgg gccccttctc 2267521 ttccaagaca aacaccgcct cgttcattgc ggtcgaatgg aaatccacgc tccaataggc 2267581 tttgaaccat catttttcca tcatgtaata cgtctgctac aatagctaga ttattatggc 2267641 cgcaccctgc gtataacgta tcctccagat gggcttcaat cgagtcatct tttgcatagg 2267701 ccgcagcaat cccgccttgt gcatagacag aattgctgtt tttgacgctt ttttttgtga 2267761 taacagtcac ttcgtatgag ggcgggaaag ctgcagctaa ggaaagtgcc gccgcccctg 2267821 aaccgatgac tgcaatcgtc tttttagaca tatgccatcc tcctgttgtt tacacctgtc 2267881 ttgacaccta tatttacaca aggataaaat aaactcaaga gttttttatg gagaacggat 2267941 ggaggaagac cggatgattt atttagatta tgcagcgaca acgcctattt gtgaggaagc 2268001 ccttactgta tatcagaagc ttagtatgga tatgtacgga aatgccagca gcctgcatga 2268061 tgcaggagga aaagcaaagc acatactgga gtactgccgt gaaaaaatcg ccaacatcat 2268121 tggcggagaa gcaagcggca tctattttac aagcggcggc actgaatcca attttctggc 2268181 cattcaatca ttgttaaacg gcctgccaaa aacgaaaaga cattttatta cgactgccat 2268241 ggagcatcag tccattcata attgcgctgc ttttttggaa cagcagggat atgatgtaac 2268301 agtcattgaa ccgaatgaat acgggcttat taccgaggaa atattactaa cccatatccg 2268361 gccggaaaca ggccttgtat ctattcagca tgcaaattct gaaaccggga tcattcagcc 2268421 cattcaacac ctgtcttcat acctgcacaa taaggggatt cttcttcatt gcgacgctgt 2268481 tcaaacgttt ggaaagatcc cgatcaatac aaaaaatctg ggagtagatg cactctcaat 2268541 gtccagccat aaaatccacg gtcctaaagg agtaggggcg gtctatatcc ggccggatgt 2268601 cccttggaaa cccgtttatc ctctgactac tcacgaatac ggattcagag ccggcaccgt 2268661 aaatgttccc gggatcggtg ccttcactgc cgctgcagaa ttgatcgtaa gcgaaatgga 2268721 aaaacagata tcccgcaatg aggcattaag aacatacttt ctagaccaaa tccgtattcg 2268781 gtctctccct gtaacccttg cagcagacac ttcgaaagca gaatgtcttc cgcatattat 2268841 agggtgtttt tttcactcat ttgaaggaca atatgttatg ttagaatgta atcggagtaa 2268901 tatttgcatt tcaaccggca gcgcttgttc tgcaggttac cacggtccgt ctgaaacaat 2268961 gaaagcatta agaaaaaccg aacaagaagc tctgcaattt atccgcatct cttttggcag 2269021 gcatacaaca gctgaacagc tggaacagtt attacatacg tttacagtgc tttgggaaca 2269081 aaagaaagga gaatttgata ttgaccgaag aattaaagct aatgggcgcc aacaggcgtg 2269141 accagcttct tctgtggctg aaggaatcta aatcaccgct gacaggagga gaactcgcaa 2269201 aaaaagcgaa cgtctcaaga caggttattg tacaggatat atcgctcttg aaagcgaaaa 2269261 atgtaccgat tatcgccaca agccaaggat atgtatacat ggatgcagcc gctcagcagc 2269321 accagcaggc agaaagaatc atagcatgtc tgcacggtcc tgaacggaca gaagaggaac 2269381 tgcagctcat cgtcgacgaa ggcgttacag taaaagacgt aaaaatcgag catcccgtat 2269441 acggagattt aactgcagcc atccaagtag gcacccggaa agaagttagc catttcatca 2269501 aaaaaatcaa ttctacgaat gctgcctact tatcacagct gaccgacggc gtgcacctgc 2269561 atacactgac agcacctgat gaacatcgca tcgatcaagc ctgccaagcc ctcgaagaag 2269621 ccggcatttt aattaaagac taaaaaaagc cctctagtgg gcttttttta taattggtaa 2269681 gactggtatg cacccagaag cctcactttg cagccgagtg cttcaagctc ctgcatggcc 2269741 cctggaatca atacatcatc aaacgctttc tcaatatcaa taataaagaa ataatggcct 2269801 aatccggttt tagtcggacg tgactcaatt tttgacaggt ttaaatttct ccaagaaaat 2269861 gcagacagca ctctatgcag cgccccggac tgatcatcct gcggcagcat gaccattaag 2269921 gtcgttttgg gcctagagct caattttgaa ttcacttcaa aagatatgtt ttcatcggga 2269981 gacaggataa caaatcttgt atgattgtcc ctataatcct gtatatcccg tttcacgatt 2270041 tttaattcgt atgtagaagc tgccatatca ttggcaatga ccccgatatt cagctcggga 2270101 tggtcactga caaactttgc tgccgccccg gtagaattgg cgtattcata tggaacggaa 2270161 ggaaaatgtc gatgaagaaa tttatggcat tgcgcaatcg cgtgtgaatg tgagtaaatt 2270221 ttgtcgagct ctttccatgc attctctctt gagggatgga cgagcaagtg ctggtgaatc 2270281 ggcaacgtca tttcacccac gattggcaaa ggctgttcat gtattaaata gtctattgtt 2270341 agattaacag atccttctaa agcattttcc aaaggaacaa aagcaaaatc aacttcgcct 2270401 gcaacggctg catctataca ctccggaatg gtgcggtaag caacatgttc ggcgccgttt 2270461 tgaaaacaag aactgactgc tagatgtgta aatgtagctg ctggacctaa ataaccgact 2270521 ttcatgacga ttttctctcc cttatgcacc tgaacctaat atttcaacct tttctacaaa 2270581 atcaaacttc ctgagcttat tcattaatgt atgaatgtct tcttccattg ccgacgtact 2270641 gatagacagt gtcacatttg ctctgccttg aagcggaatg gtctggtgaa tggaaagaac 2270701 gttgcttcca gaatcagcta ccgcctgaag aagctgagat aacgcacctg acctatcctc 2270761 caaatgaaag aaaagtgtga taatttgttc ttttaccatg gtgtagaatg gaaaaacagc 2270821 atccctgtat ttataaaacg cacttctact taaatcgacc ttttgaacgg catctgctac 2270881 tgaatctgct ttttttcgat caagcagctt tttgacttct aatgtttttc tcattgcatc 2270941 gggcaataca tcttcacgga caagataaaa tgtctcctct ttcatttgca tccccccttt 2271001 aaaatagaga gcctggcacc aggctctctt ttcagccaac attgattaat caataaattc 2271061 aaattcaaat tccagaagcc tgattatatc tccatccttg gctccgcgtt ctctgagtgc 2271121 ttcatcaaca cccattccgc gcatctgtct tgcaaaccgt ttaaccgatt catcacgtga 2271181 gaaatcagtc atcttgaata accgctcaag gctgtctcct gaaagcacaa atacaccgtc 2271241 tggatcgcgt gtaatgttaa atggcacttc ttcattttcc atcgtgtaca tgacacggtt 2271301 ttgtgtaagc tcttcctcgt catacagcgg gaattccggt gtgttctcaa gctgattggc 2271361 aacctcaaac agaagctcac gcagaccttc tcttgtcacc gcactgatcg ggaataccgg 2271421 ataatcatcc gtcagctttt ctttaaaggc ttcgagattt tccgcagcct ccggcatgtc 2271481 cattttattt gcaacgataa tttgcggacg ctcagtgaga cgcagattgt actcgctcag 2271541 ctcctggtta atcgtaagat aatcatcata tggatcacgg ccttctaagc ctgacatgtc 2271601 aatgacatga acaataaccc tcgtccgttc aatatggcgc aaaaactggt ggcccagtcc 2271661 gacgccttgg tgtgcgcctt caatcagccc tggcaaatca gccatgacaa agctgcgtcc 2271721 gtcatccgtt tcaaccatgc cgagattcgg gacaagcgtt gtaaagtgat agtccgcaat 2271781 tttcggtttt gcagatgaga caacagacag caaagtagat tttcccacac tcgggaaccc 2271841 gacaagtccg acatctgcaa gcacttttaa ttcaagaaca atgtagcgtt cttttcccgg 2271901 ctcgccgttt tctgaaagct gaggcgcggg attagccggt gtagcaaagc ggctatttcc 2271961 tcttccgcct cttccgcctc ttgcaatgac agcccgctgt ccgtgctctg ttaaatcagc 2272021 gatgacctgt tttgtatcat cgtctgtcac aacggtgccc ggcggaactt taatgaccat 2272081 atcatcagca tttcgcccgt gctggttttt ggacatgcca tgctcgccgc gaatcgcttt 2272141 aaagtgtttt ttgtatctaa aatccatcag ggtgcggaga ccttcatcta cttcaaaaac 2272201 gacgtctcct ccctttcctc cgtcaccgcc ggcagggccg cctttcggca catatttttc 2272261 acggcgaaac gcaaccatac cgttgccgcc gtcgccgcct tttacatata ctttgacctg 2272321 atctacaaac ataatgtcct ccgttctaaa ccgttaaaaa ctccgctagt ccaacccaat 2272381 ttcaatcaga cattcgtgac tcgtgatttc aaaacgcatg atatcaacgt cctcatatcc 2272441 attctgccga atatcatcaa aagcagatgg atcggcaaag gcgccgtgaa aatcaaggta 2272501 cagaatcagc tgtctgtcag gatgatccgt ttgaagcgaa accgttaaat gattttcact 2272561 ctctctgctg actgcttgat caaacagatg aaacagcttt ctcatcagtt tcgccagctt 2272621 ttgatcataa gccgacaaat ccttaatttc tccgagaact tcatattcaa gcgtcatata 2272681 atgggttttc caattaaacg taagaaaatc aaacgccaaa tgcggtgttt tcaggtttga 2272741 gagctttgat tcgtgctttg cgtctataac catttcttca atcatttcaa agacacggtc 2272801 atacttctgt aagcttaagt ttcctttaat cagctgcagc ttattcatcc aatcatgccg 2272861 ggaatggcca agcagatgaa tcagttcgtt tgttaatgcc gtgtcgctta tattttcttc 2272921 ttgatttttt gaaacatcct tcattttcgc actcccaatc atttaatttc ttatttagga 2272981 gtctgtataa gtgtgtatta tgaattataa cagagaaggc tttgttagaa aaacaattgt 2273041 ttttcccaga aatatcatgt tccttttttc tggctttggt tgatttgcag ccaggcagaa 2273101 cattttatgt attactgctt ggggaacata tccagtgggt ttgagatgtt tattctcatt 2273161 cttggcgggg tctgctcgca catactctgc atttcattct aggtgtttac tccgcatatt 2273221 gcaaaaaaaa ctccagtcat catcgaccgg agttttttga atcattattg agctacagga 2273281 tatacgctca cttttttgcg gtcacggccg aaacgttcga atttaacagt tccgtcgatt 2273341 ttcgcaaata gagtgtcatc tccgccgcgg cccacgtttt cacctgggta aatttttgtt 2273401 ccgcgttgac ggtaaaggat agaaccgcct gttacgaatt gaccgtcagc acgtttagca 2273461 cctaaacgtt tagcctcaga gtcacgtccg ttctttgtag aacctactcc ttttttagaa 2273521 gcgaaaaact gaagatctaa tctaagcatg tagctcacct cctatattat gtttgtggtc 2273581 acacgcaagt tgtctttgta atcccgttcg attgtctcca gcgaaacaat catgccttca 2273641 atcagcagct gagctttttg gcgtgcctct ggatcaagag attcagggaa ttcaaaataa 2273701 aaataacccc cgtcctctcc tatatcaaga agcggctcga agcccgcgag cacaatgacc 2273761 gcgttaacgg ccccaaacac aacggctgtc actccggcac aaacaagatc ttgtccatgt 2273821 tcagcaaaat tcgcatggcc cgtcatttca aaagacaata tgcctttatc atgagacctt 2273881 ctgattgttg cctgaatcat gcttacgcgt tgattttttc gatcgtcact ttagtgtaag 2273941 gctgacgatg accttgtttt ttatgaacgt ttttctttgg tttgtatctg aaaacagtga 2274001 tttttttcgc gcggccttgt ttttcaactt tagccgttac tgttgcgcct tcaactgtag 2274061 ggttgccgac tttcacgttg tctccgccaa caaacaaaac gtcttcaaaa gtaactgttt 2274121 cacctgcttc agcagcaagt ttttcgatgt aaacagtttg gccttcttca actttgattt 2274181 gtttaccgcc tgttttaatg attgcgtaca ttctctgcac ctcctattag actaagactc 2274241 gccagatacc agggggctgt aaaagctctt aacacctgta ctgagcggtt gtagcaatgg 2274301 tgctacatcc ataacattaa aaaatatacc aaaatacaag gcgtttgtca atcagtttta 2274361 gtagggcaga agcagttcct ccatggaaga attcgtccgc ttatcggcaa agtaagcgtg 2274421 cagcacttca ttctcgtcaa gctggctgag cttttggcct gatttttcta taataatcgg 2274481 atgcttacag ccacgtttga actcggccat cacatgatag actttatcct ccgcctttac 2274541 tgtcagcggc agaagtttct caagctccct gttttttccg taataccttt cgaggagaaa 2274601 tctcacatgg atatagtgcc tttgccgata ttcctcaaac aaggaaacag ccagaaagac 2274661 aaacaaaacc catgcgctga tttgcagagg aatcacgaat aaaacccagc acccgagcag 2274721 caggcagaag cagagcgacg tttttagatt aagccggtga gccttttgaa aaggcagctg 2274781 tttggaaaac aacaaaaata acagttttcc tccatccagc ggccagatcg gcagtaaatt 2274841 gacaaataag atagaaagat tataaaaggt gaagagttca aaggtatgct gatgaatcac 2274901 tgagacttct gcaagcatcc aggcggcaaa ctgaagccag atgtgctgaa gaggtccggc 2274961 aataatgacc gcaaactctt cctttaacgg ccgattcccg tgctcttcca cttcgaccgt 2275021 tccgccaaac ggcagcaaaa aaacacgctt gattctccaa gaaaaaaaca cagccagagc 2275081 agcatgcccc agctcatgaa tcaatacaat caggagcaga cataataatg ctttcatatg 2275141 gcctgtgagc aagcccagcg ccgcaataat ccaaagaaaa ggatgcacat ggatctttaa 2275201 gataaggtcg agccatttat tcaaatgaaa tcacctgaat cggatcaata aatttatcgc 2275261 cgtctttcat ggcaaaataa tagacccctt tattatgatc atcaagctta atcgaaccga 2275321 gctttttgcc tttatccaca aaatcatata aagcaacatc cacatctttg agctcgccat 2275381 agatactata ggtgttgtca gcatgctgca ccttaaccgt cagtcccgtt tggctgtctt 2275441 tgctgacttc aaccacatag ccttctttta cgctatcaat cttatcactg cttgtttcga 2275501 ctttaattcc ttccccattg tcctgaaaat cctgctgtac tttcccggat gcaggcgcga 2275561 tcagatcttt gcctacttca atctgctgtt ccttattttt gtgttcagga gccaggaaag 2275621 caagcggatt tccgaatttg gtttcgaacc aatggcttgc tgaagcaaat tgaaattcag 2275681 tttcaaaggt tttggctacg gcgggtttaa tctgactgac gggtccaatg tttgttttat 2275741 aggctatagc tgaaacgaga acaaggcagg ccgacagaag acatttcagg ataattgaat 2275801 ctgttttcac caatgggtgt tttccgttga atgttggcat gttatcttcg tagaccggaa 2275861 gtgttccatg cttttcctga tccgttacca tcacccagga cgggggtttc tgcttttcag 2275921 aaactgtctg agtagagaaa cgttttgagc cggaaagctg ctttcttctt ttctctaatc 2275981 gttttctgat ttcatctgct ctgtgactca ttgccatcat cctttgcatt cgttgggttt 2276041 gtacatcata tgtcttgtcc atggcaaata ttcggtttag tcaagaacaa agcaggcaaa 2276101 aacaaaaaaa acctgacaca gcatatgctt tgtcagattc ttctctttga ttctatcaca 2276161 ttaagatctt actccgaaaa atgacttaat cttagccatc attcctttgt tttgctcttc 2276221 aagcacctgt aaaggaacag attcacctaa gatgcggcgg gcaatattgc gatatgcaat 2276281 ggaagcgcgg tttttagggt ccatcgcaat cggttcgcca tgattggaag ctttaatgac 2276341 ttcatcatca tcagccacga ttccgagcaa atcgatcgac agatgctgta cgatttcgtc 2276401 gatatccatc gtgtcaccgt ttttcatcag gtgatttctg attctgttaa caacgagccg 2276461 cggcggttca atattttcct cttgctccag cagtcctata atacggtcag catcacgaac 2276521 agctgagatt tcaggcgtag tgaccacaat cgctttatca gctccggaaa cggcattttt 2276581 gtacccttgc tcgattccgg caggacagtc tatgatgaca tagtcaaatt cctgtttgag 2276641 ctcttggacc atgtttttaa tttgttcagg agcaacagct gtcttatcgc tcgtttgagc 2276701 agcgggcatt aaatagagca gatcatcgaa acgtttgtct tttacgagcg cctgatgcat 2276761 tttgcatctg ccctctacaa cgtctaccag atcgtaaata attctatttt caagacccat 2276821 tacaacatca aggttgcgca gtcctatatc agtatctact aagcatacgc gcttccctaa 2276881 aatggctaag gcggtaccga ggttcgcaga tgttgttgtc ttacctactc cgccttttcc 2276941 cgaagttatt acgatagcct cacccaattc acattcctcc ctcaagcctt gttagatcag 2277001 gtcttaaatg agccaaatgt tgaaggcgtt caatgaccat atttccgtct gtatctaaat 2277061 aagcacattc catttcgttc cctttttgaa tgtggtctgg ggagcgattt aacacatgat 2277121 tgattcttaa ttgtgtcgga agcatttcag aggcggcgat gaccgcttga ttatttccat 2277181 tgaatccagc atgcgcaatt cctttcagtg agcccagaac aaaaatgttc cctccggccc 2277241 tgactgttcc gccgggattc acgtcaccga tcaggagcaa gtcgcctttt acctgcagca 2277301 cttggcctga acggacaatt tttgaaacag aaataatttc ggcttcctct cttatctgct 2277361 gtgcttcttt tttagtaatg acttcactgt caatagaatg aacaaacaaa tctttctttg 2277421 acgcaatcaa ttcggttagc tgttcctctt gctccttata taaaaagcga tttcccagct 2277481 taacatgaac gctgattttc tggccttttc catcggtata ttgttcaatt gacagcatat 2277541 tctgaagacc atcgagaagc tcatcaaaag aacacgcatc atccagatgc aatgttagtc 2277601 cattctttgt tccttttatt gttacatatt gctgcttttt ggtcttcaca atattcacct 2277661 caacaacata ctcatttcgt caaaaaaaga taaaatcctt tttactcatc tctcaattct 2277721 ttctttagac tcataaaaaa caatctaaat ggcagaacaa gaataagagc tgctgcaata 2277781 tttaataaaa ttgtcggtat aaaccggtca agcacaaatc cgttaaacgt cataatgtct 2277841 ttatgaatca aagactgaat gccgaatacg taaaattcga gcagacagac agccagaact 2277901 gctatcaata tcactacaaa tgcgtttgta tgcaacactt taaacgcttt tgaagccaaa 2277961 tagcatagcc ctgcaaaacc aaacatgtaa acgcctaata gacttgtata gttcatgtca 2278021 tatagaaagc caaaaataaa tccgtaaatc atcgcgtgtt tttggttgat aaaagccgac 2278081 atgaatatca atacaagcat caaaaaacgc ggggcgagca cttggtcatc tgtaacgaaa 2278141 ggaaaatgca ccaaatctgt aaaaatgctt tccgcagaaa aaacaagcat cataacgaaa 2278201 gggagaagga aacgtttcac gatccttcct cctctgtatc gacagtcggc acgtcacggt 2278261 taacaacgat cacattattt aaatctgtaa ggtcagccgc aggttttaca taagcaacct 2278321 tcgttaatcc ataggaatct gactcgatat cagtcacttc accgattgtc agcccttctg 2278381 ggaaaacacc gcctgtccct gatgtttcaa taagatcgcc ttttttcacg tcttgtttat 2278441 ccttacgctc aataattgtc atcttaagac gttttttctc tttgtcatat ccttcgatca 2278501 agccgtagcc tttgctgcct ttttttccgg aaatttttgt cgcgactctg ttattgcggt 2278561 cagtatcgct taaaagctga acagcagacg taaaattgtt aagtccggag cttttgatct 2278621 tgccgattaa tgcgcctttt tcgtttgtaa cggccatatc tttcgctacg ttttgctgag 2278681 tccccttgtt aatggtgacc tgtttcgccc aattatcagg gcttctggcg atgaccgttg 2278741 ctaaaatcgg cttgtaatct ttaatcgatt tgacatggcc aagctcgtca cgcaaggatt 2278801 tgttttcttc ttcaagctct tgaagcttgg cttcatattg tgtctgtccg tcaagttttt 2278861 ctcttagacg ctcgttttct ttgtatgtgt tttttaaatc attgatgttc tcaaatattc 2278921 ctgcaaaaaa ttcggcaggc gtatgaaaaa tattttgaaa tactcccgtc gtatcgccga 2278981 tcactttctc aggccaggtg gtattgcggc cgcccttcag cgaaaatcca atcatagcca 2279041 ccaatatgat aatacacaga agtaatagca ttaaccgctt attcggcatc gtgttacacc 2279101 tcttctattg aactcccgat tatctagttt tccctttgaa aagatggatg tgctccagtg 2279161 ctttccctgt tccgatcgct acacaatcaa gcggatcttc ggcgataagg accggcattt 2279221 ttgtttcttc gctgatgact ttgtccaaat tgcgcaaaag cgctccgccg ccggttaaca 2279281 ctatacctct gtccatgata tctgctgcaa gctcaggcgg tgttttttcg agtgtgctct 2279341 tcactgcttc gacaattgta gatacagtgt cgcgtagagc gttagaaatc tcttttcctg 2279401 taatttcaat tgttttcggc aaacctgtga gcaaatcgcg gccgcggatt tccatgttgt 2279461 cggattcttc aggagcttct gcagatccga tttccatttt aatcgcttca gccgtacggt 2279521 caccgatcat cagattgtac gtttttctga tgtagttgat aatcgcgtca tccatctcat 2279581 caccggctac acggattgac tgagacgtta cgatgcctcc gagggaaata atcgcaactt 2279641 ctgtcgtacc gcccccgata tcaacaacca tgcttccagt cggttcccaa actggcagat 2279701 tggctccgat tgctgcggca aaaggctctt caatcggata cgcgtcacgc gctcccgcct 2279761 gtcttgtcgc atcgataaca gcgcgttctt caacagctgt aatgcctgat gggacacata 2279821 ccattacata tggttttctg gcaaacatgc ctttattttt tatggcctga ttgatgtaat 2279881 atttcatcat cgtcgccgtt gtttcataat cagcgataac gccgtctttc atcgggcgaa 2279941 gagccaccac gttgcccggt gtccgtccaa tcatattttt cgcatcattt ccgacagcga 2280001 caatcgattt cgtatccgtc tgcaaagcga caactgacgg ctctctcaca acaattcctt 2280061 ttccttttac aaaaacaagc gtattcgcag ttccaagatc tataccaagg tctctagcac 2280121 caattccaaa catatgtatg tatcttcctt tcttaaagca aaaataccct aaagggaaaa 2280181 actcataaac tctattatag cttaattcga cgaaaaaaaa agtgttacaa atatcctttt 2280241 tcctttaaac tcacaaattt tttatccccg atcaccaaat ggtcaagcag ctcgatgcca 2280301 atcaggtttc cgcattcaaa cagccgtctt gtcacttcaa tatcttccct gctcggcgtc 2280361 ggatctccag aaggatgatt atgaacacag ataaaggaag cggcagatcg tttaaacgct 2280421 tctttaaaca cctctcgcgg gtggacaata gatgaattca ggcttccgat aaatacggtg 2280481 cgtttatgga tgacttgatt ttttgtattt aagtataaac agacaaaatg ctcctgggtt 2280541 aaaaagcgca tatcctccat gacaagatta gcgccgtctt ccggggagcg aataacgaaa 2280601 tgttcttcgt tggctaattt atgaatccgg cttccaagct caactgctgc cagtatttga 2280661 atcgctttta ccataccgat tcccgggatg cttgacagct cttcaaccga tgcttccttg 2280721 agcaggcgca gcccgtcaaa tgagcgcagc agccggtttg acaggtccaa aacagattcg 2280781 tgtttagtcc ctgtccgcaa taatatagcc aaaagttcat gattcgctaa gttctcggct 2280841 ccgactttca ggagccgttc ccttggcttt tctttcattg ggaaatcttt gagttttaat 2280901 ggcagatcgt gtatgaccaa gcactccttt tctttccctt cccgtttata gaaccgtcat 2280961 gcccttatat caaaatggcg aagagctctc attgtttttg atataggaag gcccatgact 2281021 gaataataat ctccgtctat tttctttaca aaaagcgcgc ctcttccttg gatgccgtat 2281081 gcacctgctt tatccatcgg ctcttttgtt tcaatatatg tccaaatctc ttcttcactg 2281141 agggaccaaa acgcaacttc tgtcttatca taaaaagtct cgctgtgatt ttcagcttga 2281201 atgctgaccg cggttattac tgagtgactt cggcctgaaa gcctccgcag catagaagca 2281261 gcttcttctt gatcctgcgg tttgccaaga cattcgccgt caaggcatac cattgtatca 2281321 gcaccgataa cgattgcatg cgggtggaga tcagctacag ccttagcttt ttgttttgcc 2281381 aaccattgga cgttttcttc tggtgaaaag tttcgattta atttttcttc tacttcactg 2281441 acaataatgg agtagggcag ctggagaaga tcgaggagtt ctttcctgcg cggagattgt 2281501 gatgcaagta ttagcggttt tgtcatgttc gtcatccttt cagggtttgc ttaagaaaaa 2281561 aagatactcg tttatcctac caaatcacga ggcttgtcac aatttcagaa aaataacttt 2281621 ttcatgacaa aataaaaaaa gcctgtcact aaaggacgaa ggctcagggc actatctctt 2281681 attttacgac ggctaacagc tcctgctgag ccttccaccc ggcttcagca cttggatcct 2281741 ctaattcctt taaagcctgc aaaatcgctt ttttctctcc tgtttctgac gcttttgttt 2281801 caccaagcga cttttctatt ttctctacac tcgcttttgt aatgtcttcg tcgagaatcg 2281861 cctttgctgc aagctccgct gtttccttaa aagaatctgt catatctgac tctattgata 2281921 aggaaagctc cttgcctccc caggcttcaa aatcactgtc gattaaaacc tgtcctaact 2281981 gctgtgagac ctccttttca cttgctaagc ctgcaataac atacgtatac ccgtcatcct 2282041 ttgacagtga cacggcggaa tatccttttt cggtcaattg ttctgttaac gtttcggcgc 2282101 ccttttcatt tgaaaatttt ccggcttgca cagcgtatgt tttgtatgta ccttcagttt 2282161 gtgccgcttg tttttctgcg cctgaggttt gtttatcagc agaagtatcc cctgcttttg 2282221 ccgtttggct gcctaaagaa tcctctaaag aggccggtgc tgacgcttct ttattccccg 2282281 atatgtttaa cgcgaataac cctaatccag tgccaatgac agccgcgaag gcaatcgtcg 2282341 cggccactct ttttaccggt ttggcagccc cggtctttcc ttttgcgtaa agctttgttt 2282401 ttttcttttg aaaaggagga acaactttag ggtcctcttt aaacaccttg tcctcctcgg 2282461 aatcccaatt gaattcatct tcatcagggt gttcctggga tgccgcaacc tcttgttctg 2282521 cctgtctttt ttcctcccaa tttgaaaatg tcatgctttt attcgcctct gtctcaggcg 2282581 tctcttgttc gtaaaccgtc tcttcttttc cattaatcgt caccttgagg gctttttctg 2282641 cggctttact gtttttttta ttctttcttt ttttcaattc cgcttcctcc cttcatttgc 2282701 ttgaccgttc ttgtcggctt ttcatgctac acactttagc acaggcaaag aaaaaaagaa 2282761 caagactttt gtcgccttgt ccaaaaaacg ttcgtcaaat ttttcagcag tcagcccaat 2282821 gccattttga tataaaaaga aatgatagag tcaccgtata aataggctaa aatgctccct 2282881 gcggctatag cgggggcgaa gggaagcggc tgccttttag cgagtctacc agtcagaaca 2282941 gctgccgctc catataatgc acctatcaaa actgaaaaga aaaaggcagc tgccagcatt 2283001 ttcacaccaa gcacaaagcc aatcaccgca aataatttaa tatctcctcc ccctactccc 2283061 ccatgggtga ttgcggcaat tacagccaga aacaaaaatc cggctgccgc acctaacagg 2283121 cctgcatacc aggaatcaag cggagaaatc aatctcgcgg ccgccaaaaa gggaagaaag 2283181 aaaatcaata ttcgatttgg aatcagcata aaatgaatat ctgtcactgc aacaataatg 2283241 agaagagaga taaacaccac agcgggaaac agttccagcg atatgccaaa gcgtattcct 2283301 gcggcggcaa ataaacacgc tgtcacaagc tctgctgcgg gatacataaa agaaatccta 2283361 tgcccgcagc ttttacattt acctttttga aataggaatg acaggatggg aattaattct 2283421 gcaggagtta atgttcgccg gcaaaacggg catgatgaac ggggcgcaat aatagataga 2283481 tgtaagggga tacggcaccc ggccgtatag taaaaagaac caaggataag cccgaagata 2283541 aaaagaatgg atagcataga caacacacct ttactcattg agttctggta tggattgtag 2283601 caaaatggac atcctgagct ccaattggga atattcaatt ttacacatga aaaaaacggc 2283661 agaatctttt tttgattctg ccggagccgg atgcttttat ttcaaccttt ttcgaatgtc 2283721 agaaataaag taaagagatc cggtaatcag cacaatttca tttgagccct ttttactttc 2283781 tatgaatttg attacatcgt ctggatcttc actccagctt ttattgctga tttcacttgc 2283841 atcatagaga tcttttgcaa gggaagcacg cgggaaatca aaagaagcaa aatgaatcgc 2283901 atgagcaatg gtttccagtc ttttaatcat gttctgatac ggtttgtcct ttaacgcgct 2283961 aaacaccaca gaaatgcgtg aattggcgaa acgctgcttc atcgtttccg ccagcttttc 2284021 aacaccttct tcgttatgcg caccgtctaa atataccgga ggatgttcct gaacaagctc 2284081 taaccgtccc ggccaagcag ccttcacaag cccgctcctt aacgcttcgt cactgatatg 2284141 ggcgatattc tccttattga gccactccgc agccaaaatg gacaaagcag cattttgtct 2284201 ttgatgggtg ccaatcagag atgtccgaat atcttcatag catttctctt ccgttttgaa 2284261 tgaaaactgt tctcctgcag gcagagcctc ttcattgaaa ataacacatg catcatgcaa 2284321 tgactggaac ggcgcagcat gccgttcggc ttcatggcgg atgacctgta aagcttccgg 2284381 ctgggtaact gctgtaacga ttggaatacc ttctttaata atgccggcct tttctcctgc 2284441 aatttcttca atggtgtttc ccaaaatgtt catatgatcg tgtccgatgc ttgtaatcac 2284501 agttaagagc ggttcaacca cattagtaga atcgaatcta ccgcccagac ctgtttcaaa 2284561 aataacaaaa tcgaccttat gaaactctgc aaaatataaa aatgcacaag ctgtcataat 2284621 ttcaaattct gtcggctgtc cgtattccgt ttgatcaagg gcttcaacgt gcggtttcat 2284681 ttgattgacg agtgctgtcc attcctcatc tgaaatcggt atcccgttta cgctgatccg 2284741 ttcattaaac gtaataatat aaggcgatgt aaatgttcca accgtatatc cggcttcctg 2284801 cagcatagaa cggataaaag cgacagttga tcctttaccg tttgttcctg cgacgtggaa 2284861 cgctcggatt tttttttcag gatgtcctaa ccgcgccatc agctgtttca ttcgaccaag 2284921 tccgggcttc accccgaatt tcagcctccc gtgaatccag ctgcgcgcat cttgatatgc 2284981 agtaaacaat gataatcccc tcttttataa gacaaggcgg tttctctaga aaccgccccg 2285041 gcttttcatt aacccttcag ctcagccatt cgtttttgaa cagcgtcacg cttcgccaca 2285101 taatcttttt ctttttcacg ttcttcatca attacgtgtg caggcgcttt tttcataaat 2285161 ccttcatttc caagtttctt ttggacacgc tcaacttctt ttgtcagttt atcaaattct 2285221 ttttgcagac gggcaatttc ttcatcaata ttgattaagc cttcaagcgg aagaataacc 2285281 tctgctcctg agacaacggc cgtcatcgcc ttatcaacag cctcaatatc ggtgccgatt 2285341 ttaagcacgc tcggattcgt aaagcgttca acatatgaac ggttcgcttc gaggcgggac 2285401 gctatttcgt ctgtgcttgt tttaatgtac agttcaacct gcttgctcat tggcgtattg 2285461 acttcactgc ggatattgcg cacagaacgg atcagctcaa caagaagctt catgtcagct 2285521 gccgcttcag tatcggtatg ctccggcact actgcaggcc attgacttac tgtaatcgat 2285581 tccccttggt gaggaaggtg ctgccaaatt tcctccgtta agaatggcat aaacggatgg 2285641 agcagacgca tcgtttgatc aagtacgtaa gcaaggatgg aacgggtagt tttcttagcc 2285701 gcttcgtctt ctccataaag cggaagcttc gccatttcaa tataccaatc acagaaatca 2285761 tcccaaataa agttatataa atggcgtcct acttcaccaa attcatatcg gtcagcaagc 2285821 tgggtcacgt gctcgatcgt ttcatttaat cgcgttaaaa tccacttgtc agcgactgac 2285881 ttttcacctg acagatcaag ctcatcgtac gtcatgccat ccatattcat taatgcaaaa 2285941 cgggaggcgt tccaaatttt attggcaaaa ttccaggtcg attccacttt ttcatagctg 2286001 aagcgcagat cctggccagg agagcttcca gtcgcaagga aataacgcag agaatcggct 2286061 ccgtacttgt caatcacatc catcgggtcg acaccgttgc caagagattt actcattttc 2286121 cggccttgct cgtcacggat taagccgtgg attaaaacat ctttgaacgg gcgctcgcct 2286181 gtaaattcaa tgccttggaa aatcatgcgt gatacccaga agaaaatgat atcgtaccct 2286241 gtcacgagaa catctgtcgg atagtagcgt ttaaagtctt cagccgttac atcaggccag 2286301 cccattgtgg agaaaggcca tagcgcagaa ctgaaccatg tatccagtac gtctgtatcc 2286361 tgttcccaat tttcgctgtc ttccggcgct tcaagtccga catatagctc gcctgtttct 2286421 ttatgatacc aggcaggaat acgatggccc caccacaatt gacgggagat acaccagtcg 2286481 cggatatttt ccatccagtg taaatacgtt ttttcgaaac ggtcaggcac aaagttgacc 2286541 ttttcttctt ttttttgcag ctcaatcgct gcatcagcaa gcggctgcat gcgcacaaac 2286601 cattgtgtag aaagataagg ctccacaaca gccccgcttc gttcactatg gccgacagag 2286661 tgcatatgat cctcgatctt gaagagaact cccgcctcct gtaaatcttt cacgagcttt 2286721 ttgcggcatt caaaacgatc cataccttga tattggagcg cattttcatt catcgtgcca 2286781 tcttcattca tgacaaggat gcgttctaaa ttgtggcggt tgccaagctc gaagtcgttc 2286841 ggatcatgag caggcgtaat tttcacggca cctgaaccaa attccatatc aacatagtca 2286901 tcaccgacaa tcggaatttc acgatttaca atcggcagga tcaccgtttt tccgataagg 2286961 tgtttatagc gctcgtcttc agggtgaacg gcaacagctg tatcaccgag cattgtttca 2287021 ggacgtgtcg tcgcaatttc aattgagcct gaaccgtcag caagcggata gctcatatga 2287081 tagaatgcgc cttgaacatc cttgtaaatc acctcaatgt cggatagggc tgtttttgtc 2287141 gctgggtccc agttaataat atattcgcct ctgtagatca ggcctttttc ataaagctta 2287201 acgaatactt cccttaccgc tttgctcaag ccttcatcca gcgtaaaacg ttcacgggaa 2287261 taatctaggc caagacctaa tttcgcccac tggctgcgaa taaagtcagc atattcttcc 2287321 ttccacttcc acgtttcttc gaggaatttt tcacggccta aatcgtagcg ggatttgcct 2287381 tcttcacgaa gtttcgcctc cactttagcc tgtgtcgcga tgccggcgtg gtccatgcca 2287441 ggaagccaca gcacatcata gccctgcatg cgtttcattc ttgttacaat gtcttgcagc 2287501 gttgtgtccc atgcgtggcc aaggtgaagt ctccctgtta cgtttggcgg cgggatgaca 2287561 acagagtatg gctcttttgt ctggtcactg cccgcttcaa aaaatttgcc ttttagccaa 2287621 aaatcatatc ggtctttttc aaccgctgcc ggatcatatt tcgtcggcat tgtttgttca 2287681 ttcgtttcca tcataaccct ccagcatgtt taaaaatggc tgagaacgaa aaaagagctc 2287741 ttcatccctg taaaaggacg aaaagctctt tcgcggtacc accttttttc atgaactcaa 2287801 tcagttcatg cacttataac ggataacggg tgtttcccga atttctctac tcttctttca 2287861 agaaattatg ctcccgggcg accttccaat cagacaacat aagaagcctt tcagcaaacg 2287921 gcttctctct ctgcatgcgc cttttttgta ctcttcccgt tctaagcagg tgtatttatc 2287981 agctcattgt atacattatt tatgttcttt attatagtaa aagtgttttt gattcgtcaa 2288041 tcatcttttc caaaaacacc gctttctata cagatgggca ggcacctatt gcccaagttt 2288101 acatatgatg cttgtaaatg cgtagaggag gatgcaccgt gaagaaacgt ttcagctctt 2288161 attcgctgcc gccatgggta aggcaaattc ggcttgtatc cgcacaagtg attattccca 2288221 ttacgatttt tcaaggaatc agaaccattt tctttccgac aacctttgat gttttgctgc 2288281 tcgcaatcct aatcttttta gcttgcgccc ttcatttaga atggatataa acaaacaagt 2288341 ccgcgccatt aagacgtgga ctcgttttca gcctgaaatt ttttctcttg ttcaatctga 2288401 tgaattttca tcacaaacgg ctctatgttt ttcatttgcc aataagcctt taataattgt 2288461 gtacattcct ctttttcatg ctgtcttttc ccagtttgat aaccgttcag caccttgtac 2288521 atggctgccg gatatgccat atagctgaga aaaaggctga cttccgcttc acgcaaaggg 2288581 aatgatttcg tatatccata aaaccattcg acgcattccg gacaagcttt cggaaagcct 2288641 ctgaacattt ttgtataaaa gccgagcagg tcgttttgcg gcggaccgac agatgctctt 2288701 tcgaagtttg taaaatatcc ggtcccggca tcattataca gaaaatggtg tatagacagg 2288761 ctgccgtggt tcattacaac ccttgaaacg tccttttcct ttgcggactc ataccagtcc 2288821 tccagccgtt ccagcgcaaa gttcaccgcg gaaatggttt cagaaaaata ggttatggcc 2288881 tggagttcaa agggagaaag gtaccattcc ttctccgctc tatccacaaa ctgctcatag 2288941 aaaattttat cttgttccca cttttttttc gtttgcccgt aataacgttc aatctcatca 2289001 cgtctaacct ttagttcctg cgcggttctc tcgtgaagac gggctgtttc tctaaataaa 2289061 taagcatgtt tttgatcccg ttcttcctct tggtcaaatt ggagccaagg cattaaatag 2289121 tagatatctc cgtattgtat gcctgctgag aaaaactcac cgctatttgt tctgtaaacg 2289181 ggaacgaatg aacgaaagcc tttttcctca atcgccacca tatgatctgt aaaatgcttg 2289241 ccgcgacctt ctttcaattt tttcagggca aatatgccgt agtctgtata cactttccaa 2289301 acaagaggac tgacaggctc aataaattga gcagtcagtc cgtattcctg aagaaccgat 2289361 tgggtatctt ccatttcatt caccacattt tccgatcact tacggtttac gcatggctat 2289421 ttttatattg aggaatatag agaatctgtc ctgcttttaa ttcatcatcc aaggctaaag 2289481 aattcatcct gatcagctgc tgggatgtaa tttcataccg ttcgcataaa cgctcgatcg 2289541 tatcttcctg ctgcacaata caaattttca ttctcgaaaa ctcatccgct tcttttgtaa 2289601 agagttttgt taaataaaga gaattatcac tttcctttgt ttgaggttcc ttcgtttcag 2289661 cagcaggagc aaccctagga acagcatccg tttccttcct ttcagtctca gaagattcag 2289721 gcagctggaa ggattgaaaa ggtgtttctt ccttaggctc ttcagctgat ggtgtttttc 2289781 tcacttcaat ttcgaagctc tcttcctctt gttcttcctc ctccagcagc ttaggcgctg 2289841 aataaaaaga atcctcctct tcttgttcag gcaggaaggt acggtatgcc ggttcaggca 2289901 attcttcttg agatgcctcc tccgagcttg ttttttgatt gaaatggaaa tgtaaatcgg 2289961 cattgtcatt ctccatatat acagctgaag ctgtttctct gctatcttct atggagagag 2290021 cggcctctga tacactctcc aaagcttcat ccggttccgc ctcttcttgg caaagcgcag 2290081 gatcagcctg atccgattga gctgcttctt cattttgagc ctcttggcgc agcgcatatt 2290141 catgattagg agacactgtt gtttcctctt tttcctttgc aatcacagtc tctgaatgaa 2290201 gctcagcttc caaagcaggc gattcttctg ctccaacgtg ttcacgaagc tcagtctccg 2290261 ctggagagtc tgcttcttca cgaacatccg ctattgcagc tgccggctct gccgtttctt 2290321 tttttgcttt aacgatctct tgaatctcta tttctgaagg atcaggttct ggctcagatt 2290381 cttctgtttc cgattcagca cgaacctccg tttccggcac agcaagctct tctgactctt 2290441 cttcctcttt cacatcttct ctggcctctg gttctgaagc aaccgattca ggcggctcag 2290501 attctgcttt ttctgtctcc agttcttcac ggagccccgc tttcgagata aaaagttctg 2290561 gcggttcggc tggcggttca tgctgaagaa ctgcttcctc tgccgatgat gcacccggtt 2290621 cttctactac actatgtgcc ggcggctctg aaagctcttc ctccctgaat gccgcaggag 2290681 cttcatataa aggtatctcc ggctctttgt cttgcgtatc gtccaaaagc ccttcgatcg 2290741 ctaaatcagc ttgaattgtt aaaatgcgcg aatccgtcaa ttgatagtca aatgcgtcaa 2290801 taaagacgaa gacatcctgt aaatggctca ctttattttt cggaatggta atatccacag 2290861 gaaaacagtg agtcagttcc gcacttccat cctctctctt tctgacttgt tcaacaaacc 2290921 gcttatctgt ataaatctct tcggtatgtt tgttttgatc tatgttgtac tcacctgtaa 2290981 gttcaagcga tcctatgatt gatacataat catttacttc ctgaacccta atatcaggat 2291041 ctaatgaaat agaaagcagt tcagaaactt cctgtccttt ttggaaacag atcgattctt 2291101 ctacagaaaa ttgcaatcga tgattttgcg gcaagttcat atcctccttt catctaatcc 2291161 ttaaaattag atgtcactaa aggtgtatgt atgaactgga gaaaatatga gtgggagagc 2291221 acgaaaaaac cggcacaagg agtccttgat accggttttc actcttatct gcggctgatc 2291281 tcagcaaata ctttctcagc tgcctggatt gtgttttcaa tatcttcatc agtatgggcc 2291341 gttgagagga aaagaccttc gaattgtgat ggcggaagga ataccccttc atttgccatc 2291401 cctttataat agcttgcgaa cagcttcaaa tcagatgatt tcgctgtttc ataattgatg 2291461 actggttcgt ttgtaaagaa gaaaccgatc atcgaacctg cacggttaaa ggtatgcgga 2291521 atgccatgag ccccggcggt ttttgaaatt ccttcttcca gtctgtcgcc ttttttgatg 2291581 aaattcttgt aggattcagg tgtcagctgt ttcaatgtct ctaagccagc cgtcatcgca 2291641 agcgggttgc ctgacaatgt accagcttga tagatcggac cgcttggagc gatctgctcc 2291701 atgatttctg cctttccgcc ataagcgccg acaggaagtc cgcccccgat tacttttcct 2291761 aaacaagtca gatcaggcgt tacgccgaag tagccttgag cgcagttata atcgacccgg 2291821 aagccagtca tcacttcatc aaaaatcagc agggagccgt actgctcagt gatatcacgc 2291881 agaccctgaa ggaaaccttc ttgcggcgga acaacaccca tatttccggc aactggctct 2291941 acaatgactc ccgcaatgtc ttcaccgaat tgctggaaag caagctttac actttctaaa 2292001 tcattgtacg gaacggtgat ggtgtttttc gcaatgcctt caggcacccc cgggctgtca 2292061 ggcagaccga gagtggcaac acctgaacca gctttaatca agagagaatc gccgtgtccg 2292121 tggtagcagc cctcaaattt taaaatcttg ttgcggcccg tatagcccct tgccaaacgg 2292181 agggcactca ttgtagcctc tgttccggag cttaccattc gtacaatttc tacagatggc 2292241 acacgatcaa tgacgagctt agccagttca ttttctactt cagtcggagc accaaagctt 2292301 gtcccgtatt cagccacttt tttgaggctt tctacgacgc ggtcatttgt atgccctaaa 2292361 attaaaggcc cccatgacaa gacgtagtca atatattcat tcccgtcaat atcaaagatt 2292421 ttcgagcctt ttccgcgctc cataaaaatc gggtccatgt ctaccgattt aaatgcgcga 2292481 acgggactgt tcacaccgcc cggcatgagt ttttgcgctt ctttaaaagc cgtttttgat 2292541 ttttcatagc ttctcatctg cctcaactcc tgtcaactga ataaaattac tccgcaagcc 2292601 atttcgctgc gtctttcgca tgatacgtaa taatcaggtc ggcacccgcg cgcttcatgc 2292661 ttgtcaaaat ttccaacaca atttcttttt ctttgatcca gccgttctgc gctgcagcct 2292721 tcaccattga atactctccg cttacattat aagcgacgag cggcaaagta aactcatttt 2292781 ttacgtcacg catgatatcc atataagaaa gcgaaggttt gacaatcaaa aagtccgcgc 2292841 cttcctcaac atctgattgt gcttcgcgga gtgcctccat acggttggca gggtccatct 2292901 gatatgtttt gcggtctccg aattgcggtg tgctgtttgc tgcatcacgg aacggaccgt 2292961 aaaactcact tgaatattta acagcgtaag acatgatggg aatattgacg aatccttctt 2293021 tatcaagtgc ttctctgatc actgtaacaa atccgtccat catgtttgat ggcgcaatga 2293081 tatccgcacc tgctttcgct tggctgacag ctgtctgcgc caaaagctcc agcgattcat 2293141 cattgagaat gactccgtct ttgacaagtc cgcaatggcc gtggtctgta tattcgcaca 2293201 ggcacgtgtc agcgacaaca accatttcag ggaagtgttc tttaatttct gtgatggctt 2293261 tttggacaat tccgtgatca tggtacgctt gtgttccgca atcatctttt tcttccggga 2293321 tgccgaacac gataacagat tgaatgccca gtttgaccag ctccgctact tcatccttca 2293381 ataaatctaa tgatacatgg tgaacatcag gcattgacgg aacagctttt ttgccttcca 2293441 gcccttcaac gacaaaaatc ggatatataa aatctgatgg atgcaaacgt gtttccttta 2293501 ccatttctct cattgctttt gatgtccgca ggcggcggtg tctattaaat gattgactca 2293561 tattctctct tcctctcttg acatgctgca cattaactca agcatgccat ctattgtaaa 2293621 tgtatcaggc gtatgcgatg tgatgccgta cgtcagaagg gcatcatttg ttaaaggccc 2293681 aatgctgata caggccgtcc cattcgcctt ccactttttt aattcttctc ccaagacatg 2293741 cataaacgta tgtacggttg atgaactcgt aaatgttaca tagtcaaagg aatattgacc 2293801 cgcagcgtct ttcaatgcct caatgccttc ttcatccgga atcgtttcgt agagaaccca 2293861 ttcctttact tcaaaaccga gcgggacaag ctcttgtttt atcacatcac gtgacaaatt 2293921 ccctttcatc acggtaatgg tctcccccgg ttcagcatgc tgcttaagag cgtcagccaa 2293981 ttgttcagca atatactcct gtggcatcac atcaaccgat acgttatgca tttttaaacg 2294041 gcgcgcggtt ttttcaccga cggctgcaat ttttttatgc gcagggagaa taagctgatt 2294101 ttccttcaga taagaaaaaa agaagtctgc cccgttcaca cttgtaaaaa caagccagcc 2294161 tggcgcggca agatcctctc ttacctgttc cgcaacatca ttcggcaaag cgcggcgaaa 2294221 cgtaatcaaa gaggttaaaa ccgctttacc gccaagcgcc tccacttttt gctgaaatga 2294281 tgctgcctgt gccttattcc gggtgacaag cactgttttt cctttcaacg gaaaatcatt 2294341 ttccatcctc gtcaagctcc cgttttacac gatcaattaa atcttttgct cctttgtcag 2294401 ccataagagc ggcacagcgc tttcctactt cctccggatc gtttccggtg acggtttctt 2294461 taaaaatgat tttgccgtca ggtgaagcga caagacctgt catttcaatt tcatcctgtc 2294521 catttaacac ggagtagccc gcgatcggaa cctggcagcc gccctccatc gcgtttaaaa 2294581 aagcacgttc cgctaagaca gtccgttttg tatattcatc tgtaaactga gaaaacaacg 2294641 ccaacagctc ttcatccgat tctcggcact caatcgccag ggctccctgc cccacagcag 2294701 gcaaacagcg ctcaggctca aggaattcgg ttacgacatc ttgcttccaa cccattctgg 2294761 aaaggccggc agccgctaaa ataattgcgt cataatcctc tgtttccagc ttttgaagtc 2294821 ttgtatctat attacctcta atccatttaa ttgtaaggtc agggcgctca atcaaaagct 2294881 gcgcgcttct tcttaaactg cttgtgccaa tgacagcacc tttcttcatt tctgaaagct 2294941 ttacgcgatt ctttgaaata agggcatcac gcgggtcctc ccgttcagga atacagccga 2295001 tcacaaggcc ttcaggcaaa acagcaggca tgtccttcat gctgtgcact gccatatcaa 2295061 tctcttcgtt taaaagcgcc tgttcaattt ctttgacaaa aagccctttt ccacccactt 2295121 ttgagagtgt aacatcgaca atccggtcgc cctttgtcac gatctcttta atttcaaaag 2295181 caaacgaagg attgatttcc ttcagttttt gaataaccca ttttgtttga gtcatagcga 2295241 gtttgctccg tctggaacct actttaatcg ttctcatcat ttctttcctc ccgaatctgc 2295301 ttgggacatc gtttaactga accaatggaa ttgcgacagg cttccaagca ggaaataatt 2295361 gatcatcagc accagaaaac aagccgtatt ccacagtgca gcgacctttc cttgcagctc 2295421 cttaatcagc ctgatataaa gataatagct gtacagcagc aggacgacaa acgaaccaag 2295481 cactttggcg tcaaaccaat acagcgtttc tagtgagaca tacgcccaaa tgacgccgag 2295541 aatcaaactc agcagcagca tcggaacccc aatgacattt aaaacatacg ccatataatc 2295601 aagcttagat aaatcttcta ttctcaacag ccattttccc cactttttct ttttcagcag 2295661 atgatattga aacatatata gcacagaaaa aacgaaagaa agggaaaaag cgccgtatga 2295721 aagaatcgcc attgtaatat gaatcaccaa aagctcggat acaagctgcc cggaaaaagc 2295781 agctgactgc tgctctgtcg gtgaaaatgt gtgaatggcg atcatagaaa atcctataac 2295841 atttgtaaaa aacacgataa agtcaacacg taaaagcttt gtcagtacaa gtgacagcgt 2295901 gacaagcacc caggcataaa aataaagtgc ctctgtcaca tttaataccg gaaaccgccc 2295961 cgtcacccac ataaaatagg ccaaatacac ggtttgcaga gtccagacaa tagaaagcaa 2296021 ccagaaggcc atttttccag ccttccggtt gtgttgaaga aaatctataa aataaaagag 2296081 tacacttaac gcgtaaatga cgattgtccc ctcattaagt cttgccattg cagtatcaat 2296141 cattcagctt tcactcactt acaagtgggc taaagcccgc ttttgattca gccttcttaa 2296201 aagagtggac cttctggctg ctttcaacgg ttttcatcat ttgacggccc gcagcttctt 2296261 caatatcaaa aatctgcata aacaacgcga gcttttcttc agaatcagca tctgccgcaa 2296321 gctctttcac ctttaaaatc ggatcacgaa gcatttggtt aataatactt ttggtgtgtt 2296381 tgttcaacag ttttttctct cttgtgctta agtgaggcag cttacgctca atgctgtcca 2296441 tcgtttctga ctggatggca agcgcctttt cgcgcaatgc agaaataaca ggcacaacac 2296501 caagtgtatt catccattgt ttaaattcca caatggtttc ttcaattaac agttcaactt 2296561 tttcagctgt ttctctccgc tctttcatgt tcgcttctac aatgccttcc agatcgtcga 2296621 tatcataaag aaaaacacct tcaagatcat tcagcgccgg atcaagatct ctaggcacgg 2296681 caatgtcgac cataaacagc ggacgtccct tgcgaagctt attcgcgttt tccatcatct 2296741 ctttggacac gacaaattca cttgcaccgg ttgaactgat taaaatatca gcctccgcaa 2296801 gcgcgctttc aagctgattc aagcttctcg cttcacctga aaaacggtct gcaagctcct 2296861 tcgctttcaa gtatgttcgg ttaatgacag tgaccttgcc gattccctgt ccgtgcaggt 2296921 tttccgcagc aagctcgccc atttttcccg caccgagaat caatatgtgc ttgcttgaaa 2296981 gatttccgaa gatttttttg gcaagttcaa ctgcagcata gcttactgac accgcatttg 2297041 agccaatgtc tgtttcggcg tgagtccgtt tgcccactgt aactgcctgc ttaaacagct 2297101 cattaaaaat agtcccgatc gttttttctt gctgagctgt tttaaagctg tcgcgtacct 2297161 gtccgagaat ctgcgtttcg ccaatcacca tagaatcaag tccgcaggct acacggaata 2297221 aatgctcaac agcggcatcg ctctcataaa acgttaagaa cggtgacagc tcttctttgc 2297281 ttaattgaaa ccaatcagct aaaaactttt ttatataata acggccggta tgaagctggt 2297341 cgactaccgc ataaatttca gtgcggttgc aggttgagac aatgatgttt tcaagaatgc 2297401 ttttctcttc tttcagctgc accattgctt ctgccagctc attcggctga aaacttactt 2297461 tttcacgtat ctcaataggg gcggatttat aatctactcc cacaacaagt atatgcatcg 2297521 ctctaattac acccccaaca cccaatctta atttataatc attctaacat agaactcatt 2297581 atttataata attataacat agtttctttc acaaaatgtg aacagatttt aaaattctta 2297641 tgctatatta gaaaaagctt cagggaaaag aagcattcct attgacaata ccaaaaacag 2297701 cagaaattta ctacacatca gctctaaaaa acaagaaggt gatatgcatg aaacaaaaat 2297761 caattttatt cccttgtctg ctgcttgccg cttctgtata tgcatggcta gaaagcggcc 2297821 aagccgaact gttttcaggg caggatcaat ggcctgttct cctcatgctg ttaggcgcag 2297881 cctttgtata tcaaggaaaa aaagaagccg tcacacccca tttttttatc ggtttgcttc 2297941 tcttcgggat cggtttacac ttttttgcca agccgaaatg ggtatggtgg ccggatgatt 2298001 ttgaaatgct cctctttatg atcggcttct cacttctcgt ttcaaccgtt caaaaaaaag 2298061 aatatgtata tgaagctgtg tcgatgattt gtttttccct gtttttgtac tttttcaaac 2298121 aaattatggc atggcttgag tctgcgcata ttccaacagc gcttctgaag gagtattggc 2298181 cgtttgtctt tattggaatc agtttattgt tattattgat aaaacgaaaa aaatctatac 2298241 gataaataaa accggtagag gatcctctac cggtttatca tttttttgat cgctccccaa 2298301 gcttcgtctt ttcccttttt cgtttctgaa gaaaagagga tcagctcgtc ttccggatca 2298361 atatttaatg tttgtcggac aaccttcgcg tgtttgtccc atttaccttt cgggatctta 2298421 tccgcctttg tagcgataac aataacagga atgccgtaat actttaaaaa ttcatacatc 2298481 tgtacatcat cattagatgg cgcatgccgc aaatcaacga tctgcaccac agcttttaat 2298541 tcctcgcgtg tcgtgatata ggtttcaatc attctgcccc atgcttcacg ctcagacttt 2298601 gacactttgg caaaaccgta gcccggcaca tccacaaaat gcagctcatc attgataatg 2298661 tagaaattaa gcgtttgtgt ttttcccggc tttgatgacg ttctcgcaag atttttgcga 2298721 ttgattaatg aattgataaa agacgatttt cctacgttcg atcttccggc caatgcgatt 2298781 tccggaagcc ccccttcagg gtactgttcc ggttttactg cactgatcac gatttctgac 2298841 tttgtgactt tcatttcttc tctcctacta aggcatgttc caaaacctcg tctaagtggg 2298901 acgccaatat aaatgtcagc ccctccctga cgctttccgg aatatcctct atatcttttt 2298961 cattatcttt aggcgcaata atggtcgtta atcccgctct atgtgcgcca agcgcttttt 2299021 cctttaagcc gccgatcggc agcacgcgcc cgcgaagcgt gatttcccca gtcatgccga 2299081 cttcacgcga aaccgcccgt cccgttaaag cagaaacaag cgctgttgcc atcgtaatac 2299141 cggctgacgg accatctttt ggcaccgcac cctctggtac atgtatatga atatcatact 2299201 tctcatgaaa gtcaggttca atgccaagtt cttctgtttt ggatcgcaca tagctgaatg 2299261 cagcctgagc agactctctc ataacatctc cgagctttcc tgtcaggatt aatttccctt 2299321 ttcccggtga aagcgatact tcaatcgaaa gcgtatctcc gccaacggtt gtatacgcaa 2299381 gccctgtcac tacaccaact tgatcctctg tttcagcttg tccatatctg aaaatgcgtt 2299441 ttccgataaa atcttgaagg ttcttctcag taaccgtaat tcgttttcgc tcttcagcaa 2299501 caatggcttt tgcagcttta cggcaaattg cggcaagctg gcgttcaagg cttcttacac 2299561 ccgcttctct cgtatagtaa cgaataatat caagaatcgc ctgatcacgc agctgaagat 2299621 tgcttttctt cagcccgtgt tctttgattt gctttggaag caagtgatcc tttacaattt 2299681 caagtttttc tatttctgtg tagcctgcga tattaataat ttccattctg tctctgagcg 2299741 ggcccgggat tgtggccaaa ttgttcgccg ttgcgataaa cagcactttg gataaatcaa 2299801 aggtttcttc aatatagtga tcactgaagc tgctgttttg ctctggatca agcacttcaa 2299861 gcatagcgga tgatgggtct cctctaaaat cagatgacat tttgtcaatt tcgtctaata 2299921 agaagaccgg attcagcttg cccgcttttt tcatcccttg aataatacgt ccaggcattg 2299981 ctccgacata ggtccgtctg tgtccgcgta tctctgattc atcccgaact cctccgagtg 2300041 agattctgac gaatttgcgt cccaagcttt ttgcaattga tttggctaaa gacgtttttc 2300101 cgacacctgg aggtcctgcc aaacagagaa tcgggccttt cagggatttt gtcagcttct 2300161 ggacagccaa atattctaaa atacgttctt ttactttttc aagcccgtgg tgctcttcgt 2300221 ccaagagacg tcctgcttct ttcaaatcaa gcttatcatc tgtttcatcc gtccacggaa 2300281 gagcaaccag ccagtcgata tagttgcgga tcacagagct ttccgcagaa cttgacggaa 2300341 ttttttcata tctgttcaat tctttaagcg ctgtttcttt cacatgatca ggcatgcctg 2300401 cttcttcgat tttttccgtc agcgtctgaa cttcgccagt tttgccttct ttatcgccaa 2300461 gctctttttg gatcgccttc atttgttcac gcaagtagta ttccttctgc gtacgctcca 2300521 tcgaacgttt gacgcgctgg ccgatttttt tctcaatctc cagcacttct ttttcattat 2300581 taataaaatc aatgaccttg ttcagcctgt ctttgacatc agccgtttct aaaatatcct 2300641 gcttatcctt tagtttaagg ggcagatgag aagcaacgat gtctgccatt ctccccggct 2300701 cttcgatatc agtaaccgca gcgtacgttt cggccgagat ttttttagaa atttttatgt 2300761 actgatcaaa gtggtctagc aaagtccgca tcaatgcttc gtcttctgta tcttttgaat 2300821 catcttcatg aataagttga atgtcaaccg acgtgtaatc ctcgtgttca ttgtatttga 2300881 cgatatgggc gcgcttgagg ccctccacca acacacgaat cgtaccgttc ggaagcttca 2300941 gcatttgctt aatttttgta taggtgccga cagtgaaaat ctcgtcttca ccaggttcgt 2301001 ctatcgaaat atcctgctga gtggctaaaa atatcatatg atcatgcatc attgcctgtt 2301061 caagagcctg aaccgacttg tcacgtccta catctaaatg caaaaccatc gtcgggtaca 2301121 ctaataaacc tcttaaaggg aggagcggga tgctgcgttt taattcttct gccatgtgac 2301181 tgacacctcc gtgactttag tatgaaccat tataatacaa ctttttcatc cttgtacaat 2301241 aaacggcatg gttccatttt ctataaaaca gtctcctcgt agtataccct ttctttctga 2301301 tatgaaaaag gaaaagatgt ccttcatgaa aaaaacccta ttatcaaaat agggtttaaa 2301361 cggattcttt attgatttcg atatgaaacg gtttttgttc cgttggcgga ttcaccaaaa 2301421 tttcatcaag cacttcttgg aacgtcttca ctgcaataat ctcgatcccg tcaatctgct 2301481 ttaagatggc ctgctgattt tcatatggga taatcacctt tttcgcaccg gactgcttgg 2301541 ccgcttttat tttcggaatg acgcctccga tgggtttcac aagaccgttc aggctgattt 2301601 cgcccgtcat cgcaacggta ttgtcaatag gaattttgtg tatcgccgag aaaatccccg 2301661 ccgccatcgc aatgcctgct gacggcccat caatcggaat ccctcctggg aaattgatgt 2301721 gaatatcata atcagaaggc ttcattccca ttgtccggag cacggttaat acattttcaa 2301781 ccgaaccctt cgccatgctt tttcgcctga tcgattttga ttggctgccg atgctttctt 2301841 cttcagctat tcctgtgatg ttaattgatc ctttatcttg agccgcggtt acacttactt 2301901 cgatttccag aagcgatccg ctgttaggcc catagactgc aagcccattt acaatgccaa 2301961 cctgtggttc aacaccgatt ttttgctcgt gctttggagt aagctgactg gagtgaatga 2302021 cccattcaat atcctcaatc gtaatgtcct ttcgattctc cgttacagcc atccccgctg 2302081 cgatttgaat catattgacg gcttcccgcc cgttccgcgt gtagctggtc aaaagatcca 2302141 gtccttcttc ggagatattt ttttcaattt tatccgctgc tgttttggca accgttttca 2302201 gctcgtcctt ttcaagctcg cggaaaaaaa cctccaaaca gcgggaccgg atagctggcg 2302261 gaatttcgtt tggcattctc gtggtcgcgc caatcaagcg aaaatcagcc ggcagcccat 2302321 tttgaaaaat atcatgaata tgattcggaa tttgtgtatt ttcctcactg taatacgcac 2302381 tgtctaaaaa gacttttctg tcctcaagca ccttcagcat tttattcatt tgaataggat 2302441 gcagctcccc tatttcatca ataaacagca caccgccatg ggcatgggtg acagctccct 2302501 gcttcggctg cggaatccca gcctgtccca tcgctccggc cccttggtat atcgggtcat 2302561 ggacagagcc gatgagcgga tcggcaattc ctctttcatc aaaacgggct gttgtcgcat 2302621 cgagttccac aaagacagcc tgctctttaa acggtgattg tttatgtttt tttgcttctt 2302681 ccaacacaag ccgcgcagca gccgttttcc caactcccgg tggcccatag acaatcacat 2302741 gctgaggatt tggcccgcat aaagccgcct ttaatgcttt aatgccgtct tcctgtccga 2302801 cgatatcttt aaagcttttg gggcggacct tctcagataa tggctcggac aagctgatag 2302861 cgcgcatttt ccgaagctgc tccatttcct tctttgattc tttatctatc gtgacctttt 2302921 gtgtcctttg atttttaagc aaattccaaa aatacaaacc gatgatgatc ccaaaaaaca 2302981 gctgaataaa taacgcgatc cctgtccaac tcatggtggt ccctcctgaa aaacaattta 2303041 tgtatccaat tcattcctct gattgctagt atctcccata gaagacggga ataaacgttt 2303101 ttccggaaga gttgcatgca aaaaaacctc ctgagtgtta ccactcagga ggtttgtgct 2303161 tatctttatg cagatgtttt atcttggctt acctcagtgc cgtcttttaa taagaggcga 2303221 ggaggctctc cgtgtgtcac agttgccccg gtgattacac atttttcaat gtcatcacga 2303281 gaaggcagct caaacatcac atcaagcatg atgccttcaa tgatagaacg gagtccgcgt 2303341 gctccagtct tgcgttcaat tgctttttta gcaatttcag aaagcgcttc ttcttcaaac 2303401 tcaagctcaa cgttgtcaag ctcaagcatt ttcttgaatt gcttaacaag agcgtttttc 2303461 ggttttgtta agatcgcaac caatgcttct tcgtcaagct tttcaaggct tgcaataacc 2303521 ggaagacgtc cgataaattc aggaattaac ccgaaacgga gcaaatcttc tggaagcact 2303581 tttgaaagaa gatcttcttt ctcaagatca gcagctttat tgtcggcacc gaatccaatc 2303641 actttttggc ctaaacggcg tttgatgatt tgttcgatac catcgaaagc tccgccgcaa 2303701 atgaacaaaa tatttgttgt gtcaatttga atgaattctt gatgaggatg cttacgtcca 2303761 ccttgaggcg gtacgcttgc cactgtaccc tcaagaattt taagcaatgc ctgctgtaca 2303821 ccctcacctg acacatcacg tgtgatagac gggttttcag attttctagc cactttatcg 2303881 atttcatcaa tatagataat gcctttttcg gctttttcca catcataatc agcagcttgg 2303941 atgagcttca agagaatatt ctctacatct tcacccacgt atccagcttc agtcaaagat 2304001 gtagcgtccg caatcgcaaa cggcacattt aaaatgcgag ccaatgtttg cgccagaagg 2304061 gttttaccgc ttcccgtagg gccgattaat gaaatattac tttttgaaag ctcaacatca 2304121 tcaactttgc tgttggagtt aatgcgctta tagtggttat acacagcaac agcaagtgat 2304181 ttcttcgctt gatcttggcc gatgacatat tcattcaaaa tttcgcgaat ttcctgaggc 2304241 tttggtacgt ctttaaattc tacttcttct tctgttccga gttcttcctc tacaatttca 2304301 gtgcagagtt cgatacattc gtcacatata tatacaccag gtccagctac aagcttacga 2304361 acctgatctt gtgtttttcc acagaacgag cattttaatt gtcctttttc ctcgttaaat 2304421 ttaaacattc tttcacccct taatcttgtc tcactttttc ttttaccggc agagcaaaag 2304481 aaaatgattc ttgaaacgaa cgagtatgta ttgcatttta ccatactttc caaaaagacg 2304541 gtaacaatgt gtttctgact tgcacattct atatgtatga caaaaaacag ccctgcatta 2304601 actatattgc cccaagaaaa agagataact cataattgta caaaacaagg cacgaatgat 2304661 tcgcgccctg ttttattagt actattatta tgcaccatat taacggtttt ctacaagaaa 2304721 atcaattgct ttgcgaactt ttaaatcttc tttcatcgcg tcagtagaac cgatggcttg 2304781 tttaatattt tcaacaggca tgttgtatgc ttcagccatt tttgtaagct cagcatcaac 2304841 ttcctcatct gatacttcaa ggttttccgc tttcgcaatc gcctcaagag tcaggttaga 2304901 ttttacgcgt ttttcagcat cttctttcat ttgctcttta agcgcagctt catcttggcc 2304961 tgagaattga gtgtaaagct caaggttcat gccttgcatt tgcagacgct gttcgaattc 2305021 tttcagcatg cggtcaagct cagtgtcgac cattgcttga ggcacatcga tttcagcatt 2305081 ttcagaagct ttcagaacaa gctcttcacg caatttagcg tcagcttcgt tttcttttgc 2305141 ttcttctaaa cgtttctttg ttttttcagt taattcagca agtgtttcca cttcttcatc 2305201 gatatctttt gcgaattcat cgtcaagctc aggaagctct ttcgctttga tttcgtgaat 2305261 tttcacttta aacacagctg gtttgcctgc aagatcttca gcgtggtact cctcagggaa 2305321 tgtcacttca acatccttct cagcacctgc ttcaaggcca actaattgat cttcgaagcc 2305381 agggatgaat gaaccagaac ctacttctag agagtagttt tcagcttttc cgccttcgaa 2305441 agcttcgccg tcaacgaatc cttcgaaatc aagaacaact gtgtttcctt cttcaacggc 2305501 gccttcttct tttacaacaa gctcagcttg acgctcttga agggctttta gttcgttttg 2305561 aacatcttcg tcagttacag ttgtgtcgtc tttttcaatg cccaggcctt tgtattcgcc 2305621 aagcttcact tcaggtttta ctgttacttt cgcagtgaag attaagcttt cgcctttttc 2305681 gattttttca acatcgattt caggacggtc tacaggctcg attccagctt cttcaaccgc 2305741 tttagggtat tctacaggaa gaagaatatc caaagcatct tggtaaagag cttctacgcc 2305801 aaagcgctgt tcgaataatc cgcgaggaat tttaccttta cggaatccag gaattgaaac 2305861 ttgttttact acttttttaa atgcatcatc aagtgctgtt ttaaacgttt cagcatcaac 2305921 ttcaaccgtt aaaacgcctt cgttgccttc ttgtttttcc cattttacag acatgtgttt 2305981 ccctccaaaa atctattcag gttgtgtcgg tcttccattc taaagcaatc attcggcttc 2306041 gtccaacaaa aacaaagctg ccaaagatca gaatcattat gtatagatgt taataatgaa 2306101 ctgcaaagcc tgtccaaccg tatttcttat aacccgttat acacaaatac aaccactata 2306161 ttataacata acacatagcg ctttcaacta tatggcgcga tttacaaata agaaatttct 2306221 tcaatatctt ttaacattgt gcaagcttca tcgagttctc tgtctgtaaa ttcatacatc 2306281 atatgaagtt cttcgctttc aatttcaatc ccgtgcatct cgtaaccgac tttatgaagg 2306341 gcagccgccc aaaggtcagc cgacagcaat ttcggctgga acggatataa aacgtacaaa 2306401 tgtcttctcc acaattcttc tactgctgca tataaggttg gattttcatt tccaagtgtc 2306461 tcatctagca ccctgagaac acggtgaaga atcggcgcgg catcaggcgg aacaatctct 2306521 gacggttcaa ttgtcaacga ctcgccaaat ttactaatgt gtacaggttt actgtactca 2306581 tgctcagcca acagcatgac aatcatcgtt ttgataatcg gatgggctga ggggtcttgg 2306641 aggattgttt tgagcaatcc tgtatacttt gctacgttac ggtcttttaa ggaatgaatg 2306701 agattcattt gctcctcagg gcttgccagc actttctcgg tgtcaattgt atcctcatat 2306761 tcttcggccc aagcctcgtc ctcacgatcc ggatcggtca ttttccggct gaaatccagc 2306821 agcttataaa attgctcggc actttctgcc ggcagctgat tttcttccaa aacggcttca 2306881 atggtgcttt tgacttcttc gtactttttg agctgaatta agatggtcat gtacacctgc 2306941 aaaaccgtaa aataatggcc ataaccttct ttgagcatct tctcgcacac gctttctgcc 2307001 tcttccagct cgcccagctc taaaaagcag atggccatcc ctaagtgaag atcggattca 2307061 gtatcatcat atttcatcgc ttctgaaaac agttcaagcg cttcttgata ctttttttcc 2307121 ttgagtgatg acatcccttt ttccacaagg cggtctttca gatgaggaaa aggaataatt 2307181 tttgcgtttt tcttgtcatg cgtcatacct atattccttt caggcattta ttttgttcaa 2307241 gtgtatcaac acctgtgaac aaaaacaaga aatgaaaggt ttcaccaggc aaaaaaagcc 2307301 gccggacaaa taccggccgc tttttcaggc ttgaagccaa gagcttcttt gtgattcaaa 2307361 ttgcttgatt tcatcttcca gcagcagcgt taatgaaatt tcatcatatc cgttgatcag 2307421 catctctttc caatgcggat caacttcaaa tgaaatttga ttgccttcac tgtcatgaat 2307481 cagctgattt tcaaggtcaa cagtcatttg caatgactgg ttttcatact ggccgacaag 2307541 ctgtttccaa ttgtcatatg gcatgcggat cggaagcatg ccgtttttaa agcagttctg 2307601 atggaaaata tcagcgaatg acggcgcaat gataatttta aacccataat catcaagtgc 2307661 ccacggagcg tgttcacgcg atgacccgca gccgaagttt tctcctgcta ttaaaatgga 2307721 agctccttga taaacaggct ggtttaattc aaattcaggg ttcggttcac cattcgcatc 2307781 atatctccag tcaaagaatg caaaacgtcc gtagcctgtt ctttcaatcc tcttcaaaaa 2307841 ttgcttagga ataatctggt ctgtatccac attgatccga tttaatacgg ctgctttccc 2307901 cgtatgtgat ttcaaaggtt ccatctcgcg cactccttac acaactgttt tttcctgata 2307961 aaactttctg acatcaacga agtgtccgtg aatggcagcc atcgcagcca ttgccgggct 2308021 gacgagatgt gttcttgcac cttttccttg tctgccctcg aagttgcggt tagaggttga 2308081 tgcacagcgc tctccctcag gaacaacatc attattcata ctcaaacaca tgctgcagcc 2308141 tgactctctc cattcaaatc cagcttccaa gaaaatctgg tcaagccctt ctttttcagc 2308201 ctgaagcttc acgctttggg atccgggcac gacgatggcc cttacgctgt cagctacctt 2308261 cttccctttg atcatgtcag cagcctgtcg aaggtcagtc atgcgggaat ttgtgcagga 2308321 accgataaat acgtgctcca ctttaatgtc ttcaattttt tggtgaggag tcaatcccat 2308381 atattcataa gcacgaatcg cttctttttt atcgtcttct gcagaaaagc tttccggcgc 2308441 aggaacttca gaatcgacag gaagaaccat tcccgggtta atgccccatg tcaccatagg 2308501 ggaaattttg ttgccgtcaa ggacgataga tttatcgtaa acagcgcccg ggtctgtgcg 2308561 cagcgccttc cattcctcta cggccttgtc aaattcttcg ccttttggcg tgtacttgcg 2308621 atttttgcaa tattcaaacg tcacctcgtc aggtgcaatc aaacctgctc ttgctcctgc 2308681 ttcaattgac atgttacaaa cagtcattcg ttcatccatc gtcatatttc tgaatacttc 2308741 cccagtgtat tcaatgacgt agcctgtgcc gaatttcaca ccgtatttgc cgatgacagc 2308801 aaggatgaca tcctttgccg ttaccccttt ttgaagcgtt ccatctacgc gcacttcaag 2308861 tgtttttgga cgctgctgcc aaagtgtctg tgtggaaagg acatgttcaa cttcactcgt 2308921 cccgattcca aatgcaagag cgccgaaagc gccatgtgtt gatgtatgac tgtcaccgca 2308981 cacaatcgtt ttccctggaa gcgttaagcc tagttcaggt ccgacgacat ggacaatccc 2309041 ttgatccaca ctgtgaagat cggcaaggcg cacgccaaat tcctcacagt ttctttcaag 2309101 cgccgttacc tggcgtttcg caacttcatc ctttatctca aaacgattga cagtcgggat 2309161 gttgtggtcc attgtcgcaa atgtgttttg gggtcttctg acctttcttc ccttttgtct 2309221 caagccttca aatgcctgag gagacgtcac ctcatgaatg aggtgcaaat caatatagag 2309281 aagatccggc tttccctcac catgttttac aatatgctga tcccaaatct tttcgatgat 2309341 tgttcgaggc atcatctttt atttcctccc tctacctaga gctaagaccg cttaacgtaa 2309401 gctgtcacac attagaaatt gtattttcac tcatgattgc tgccttaact tcctctgtaa 2309461 tggcctgagt gctgctgaac tcttcactcc gtgccaagtc tcttgttctt tttccagaag 2309521 ccaagacttt gtttaccgca tcttctacag ctttcgcttc ctcttcaagc ccgaaagatg 2309581 ttctcaaaag cattgccgct gacaatatgg ctgcgaacgg atttgccatc cctttaccgg 2309641 caatatcagg cgcggagcca tgaacaggtt caaacagatg aaggccagag cttgataggc 2309701 tggctgacgg gagcattccg agcgagcctg taagcatgga cgcttcatcg cttaaaatat 2309761 caccgaacat attttcagtc accacgacat caaattgatt cggtgcataa attagctgca 2309821 tggccgcgtt atccacaagc atgtgctcaa gcttcacatc aggaaattct tgtgcaacgt 2309881 cctcagccac ttcacgccac agccggcttg attcaagaac attcgcttta tctacagagg 2309941 tcactttgcc ttttctggct gccgccattt tgaagccctc tctgatcact cgttcaattt 2310001 ccgttcgctt ataaaacagt gtatctactg cttcctgctc accttcagtg tttacataac 2310061 gtttgctcgg ctggccgaaa tacaagccgc ctgtgagctc acgaacgata acgaaatcaa 2310121 cattatctat atattctttt ttcaaaggcg aagcgtcaga aaggctttca aataccttca 2310181 caggccgcaa attcgcaaac aaatcaagct gttttctgat gctgagcagc cctttttccg 2310241 gtctcagttc cgaaggattt tgatcccatt tcggtccgcc gacagcacca agcaatatcg 2310301 cgtctgcatt tttacaagca gcaacggttt cctccgggag ggggttatga tgttcatcaa 2310361 tagccgcccc tccaatcagg ccatattcaa attcaaattc atggttaaag cgttcggcaa 2310421 cacttttcag tacgtctgtc gctgattcta atacttcagg gccgatcccg tctccgggca 2310481 atagagcaat acgtttcttc aagttaaccg ttctcctttc ttttatgatc cgacagctgt 2310541 gtggtttttc aatccgctca tattcgactg gaaaaccaat tgacggttta ctgcgttcaa 2310601 ataggctttc gctgatgctt ctaatacgtc ttgcgctatg ccccgccctg ctgattcttt 2310661 tccgttcacc aaaactctta catacacctg ggcaaatgca tcttcgcctt ttctattaga 2310721 ctgaatgcgg tagtctaaga gctccacatc cttatcgatg cagcgctcaa gcgtattgta 2310781 gattgcttcc acgcttccag ctccagttgc agcttcctga ataagctgtg cgttttcttg 2310841 atttttcaaa gatagagtag ccgtagggac ctgacttgtt ccgtaatgta cttgcagaga 2310901 aagaaattca tacccaatct tgcgatctgt tactttttct tctaaaataa gagaaacaag 2310961 atcctcatca gtgatttctt ttttcttctc agtcaactct ttgaacatcg taaagaattt 2311021 attaatctct tcactgtcaa attggaatcc taaagcagtc agccggtctt taaatgcgtg 2311081 gcgtccggaa tgtttaccta ggacaagcgc atctgcggtt acgccgacaa gctccggtga 2311141 aataatttca taagtcgatt tttcctttaa aaagccgtcc tgatggatgc ctgattcatg 2311201 agcaaatgca ttatctccaa caaccgcttt gttgcgcggg acagccatgc ctgtcagttt 2311261 gcttactaaa tcacttgttc tcttaatctc gttcagcgta atacctgttt cgacttggta 2311321 gaaatctttt ctggtatgga gggctacggc aatttcctct aatgccgcgt ttccggctct 2311381 ttcaccgatc ccgttcacag cgcattcgat ttgatcagcg ccattttcaa tcgcagcaag 2311441 agagtttgcg actgccattc ccaaatcatc atgacagtgg gctgaaagct ttgctttgtg 2311501 aatgttcgga acgttttctt tcatatattt aaagatattt ccgtattccg ccggggccag 2311561 gtagccgaca gtgtccggaa gattgataac actggcgcct gcgtcaatca ctttctcgac 2311621 gatttctgct agaaacggca gttcagtgcg gcaggcatct tcagctgacc attgcacaat 2311681 cggaaaacgt tcttttgcgt atttcaccat tccaactgct ctttcaatga cttgttcacg 2311741 tgtcattttc agcttgtgct tcaaatgaat gtccgatgtc gcgataaata catgaattct 2311801 tggttgagcg ccatccttta acgcttccca agcagcatca atatcacctt ttacacaacg 2311861 ggccagacca gttactgaac aatttttaat ggttcttgcg atttcctgaa cagctaaaaa 2311921 gtcacctcgg gacgaagcgg gaaatcccgc ttcaatgatg tctgccccga gtctttcgag 2311981 ctgcttagct atggcaagtt tctcctgtgt attcaagttc actccagggg actgttcacc 2312041 atcacgaagc gtcgtatcga aaaaattaat tttgcgcaac ggagaccacc gcttccttct 2312101 tcttgccttg tttcacaaac ggcatcattt cacgaagctt tcttcccact acttcgattt 2312161 gatgttcgtt ctcgcttgca ttgatagcgt tgaaacgagg acggtttact tggttttcga 2312221 cgatccactc ttttgcgaat gtaccgtttt ggatatcttt taatacttct ttcatagatt 2312281 cttttacttt ggcgtccaca acgcgagggc ctgatacgaa atctccccac tgtgctgtgt 2312341 cagagattga atatctcatt cctgcaagtc cttcttcgta cataaggtct acgattaatt 2312401 tcagctcatg aagacactcg aagtatgcaa gttcaggctg ataacctgct tcagttaagg 2312461 tttcaaatcc ggctttgaca agcgcgctta atccgccgca aagaactgct tgctcaccga 2312521 acaaatctgt ttctgtttct tctttaaatg tcgtttctaa tacgcccgct cttgcgccgc 2312581 cgattccttt agcataagcg agggctttgt ctcttgcttc tccagtcaca tcttgataga 2312641 ttgcgaacaa tgcaggtacg ccagctcctt gctcatatgt tcttcttacc aagtgtcccg 2312701 ggcctttagg ggccactaag aatacatcta catccgccgg aggaacaatt tgatggaaat 2312761 gcacgttaaa tccatgagcg aatactaatg attttcctgc tgtcaattca tctttgattt 2312821 cagcttcgta tactttttgc tgctgctcat ccggaagcag aaccatgatg atttcggctt 2312881 gggctgccgc ttcttttact gaaaatactt tatgtccgtc ttcttgggct tgagtgaaag 2312941 attttccttg tctaacaccg acgatcacgt ctactccgct ttctttaagg ttcagggcat 2313001 gtgcgtggcc ttgcgaaccg tacccgataa ccgctactgt ttttccagcc aatacgttct 2313061 ctttgatatc accgttataa tatactttta ccatttcaat ctctcccttg ttatgtttta 2313121 tacaatagat attgttttat tggatgacgc cttttgctgg gttcccctcg caaaagccgt 2313181 tgtacctgtt ctcgcgattt ctttaatgcc ataaggtttt aataactcaa taagcgcttc 2313241 aattttgtta gattcacctg tcacctgaac aacgatgctg tctctgctga catcaacgac 2313301 agaggctcta aacggttcta tgattccatt aatctctgtt cttgttgaag gtgcggagac 2313361 aaccttgatt aaggccagct ccctctggac aatcgattga tttgtgatgt ctgtgacttt 2313421 cagcacatca atctgtttgt tgagctgttt cgttaactgt tcaacatcat tttcaccttc 2313481 aacatgaacg acgaaggtga ttctggaaac gccggctgtt tctgtgtgtc caactgtaat 2313541 gctttcaatg ttgtaatgcc tttttgtgaa tagaccggtg atccggttta acaccccgga 2313601 gcggttcacc acagtcaatg tgataattct tttcaaggtt tcacccccac catttcatgc 2313661 agccctttcc ccggagccac catcgggaat actttttctt cgctggcaac ccgcacgtca 2313721 atgacaacag gttctcttga tgttaatgcc tcttccagct tttcctttgc ttccgcttct 2313781 gatgaaattc tgatgccttt aatgccgtat gcttcggaca atttgacgaa gtcaggctga 2313841 gaagcgaatt tagattctga ataacgttct tcatagaaaa tttcctgcca ctgtctgacc 2313901 attccgagac aagcgttatt taaaatcact accttgaccg gaagatttaa ttcgcgaata 2313961 acatcgagtt cttgaagcgt catttggaat ccgccgtctc cgacaaccgc gacaacagta 2314021 gcatcttttt cggccagctg tgcgccgatc gccgccggaa gaccgaatcc catcgttcca 2314081 agtccgcctg acgtgaccca tttatctgct ttttggaacg gataaaattg cgctgaccac 2314141 atttgatgct ggcctacatc cgttgcgaca atggcctctc cttttgtaaa ttgatgaata 2314201 tattcaatca atttctgagg tttaaaacct tcttcttcat tatctacata ccagagcgga 2314261 tactcttctt tccattctgc gagctgtttt ttccattcgc ttgaatcgct ttgtttgccg 2314321 tcttgtttga tcagctcctg caggacaatt ttgctgtctc cgactacagg aatctgtgtt 2314381 ttcatgattt ttccgatttc agctggatca atatcgatgt gggctatctt tgcgtttctg 2314441 gcaaagtgtt tcaggtttcc tgtgacacgg tcatcaaaac gggcgccgat actgattaat 2314501 agatcacatt catgaagggc catattggct gtataagtac cgtgcattcc cgccatccct 2314561 aggaaaagcg gatggtcagc cgggaagcct ccgagcccca aaagggtgtg tgccacaggg 2314621 atttgctgct gttcagcata attttttaat tcttctgacg cttttccgtg cagtacgccc 2314681 gcacccgcca ggatcaccgg ttttttcgca ctgctcacgg cttccacaag cttgcggatc 2314741 tgcaaataat tcggctctgt tgtcggctgg tatcccggga gattcatctc atgatcgtag 2314801 ctgaattctc cttcaattgt tgctacatct ttcggaatat caatcaatac aggtccgggt 2314861 cttccagttg ttgcaatatg gaacgcttct ttaatgatgc gcggcagatc ttccggctgg 2314921 cgaacctggt agctgtgttt tgttactggc atcgtaatcc ctaaaatgtc tgcttcctga 2314981 aatgcatcgc tcccgattac agaggttgct acctgccctg taaagacgac taacggcaat 2315041 gaatcaatca tggcatcagc aaggcctgta acaaggtttg tcgctcccgg ccctgacgtg 2315101 gcaatgacga cacccggttt tccggagacc cttgcgtatc cctccgctgc atgaattgct 2315161 ccttgttcgt gacggggaag gatatgtacc aaccctgaat tgtatagctt atcgtaaatc 2315221 ggaagcacag ccccgcccgg ataaccgaag atcatttcta ctttctcttt ttttaatgat 2315281 tcaatcagca ttaatgctcc gctcatcgtc tgtgtacatt cggcagatgc tgaatccacc 2315341 tgtacattag tccccatttt agttcctcct tttggatttt catcctttaa agatcatctt 2315401 ttcattagct agatagctga ttattcaata aaaaaagccc ttccgcccac aatcagccgc 2315461 gcagtaactg cgatagctaa aaggggcgaa aaggcttttc tttccgcggt accacccttg 2315521 tttacggcct gttaatcggc cgtctcatgg atatttctat ccgctttagt aacgagtgaa 2315581 tcaagttcac ccggccaagt cctactgtca tttcagactg gcactctgag gcgagttcac 2315641 cttgtaaagc ttcgccggtt ctcagctaac ccggttctct gtggaaaact ttatcaaggc 2315701 tacttatcct catctgcgct tttcatattc agccttcgga acggctttcc agctgttcaa 2315761 gaaggtcgtt tgtttttcat ttttttagaa tcatactgcg atgattttcg cttgtgaagc 2315821 ttgcatttat cttttgttga actcatatta cgccgctttg gacgcagtgt caacagcatt 2315881 ttttaaaatt attagacaat tttgattaat caatctatat tgtatacgct ttcattattg 2315941 gtacaaaagg aattgcaaat gttaaaagtt tttataattt ttttattaat ctatcaagaa 2316001 tacaccagaa ttatttaatt ttatataaac atggaagatt ttataacacg atatggttcg 2316061 tatatggatt gagtctgaca gatcatcttg caatccattt caatttcgga taggcacttc 2316121 tcttgttccc tcggcataca ttaatgatat cttgcaaaga aaaggtgata cgatgaataa 2316181 atcatttgca gacatgcaag gatttcctgc gggctttcca agcttcccca actttccgca 2316241 gcagtactat cctgctgtcc ctccctttta ccagcaaagc cagcagccat ttggaggcta 2316301 cggatacgga cagccgttca gtcaggcata cagcccgtta accactccct ctggaatgta 2316361 ctcctcattc ccatacgctt caggatttta cggacagcaa ttttcaggtg caggctttag 2316421 cggccatggc ggcagcttaa gtgctccagc gatacatgcc ggcggattca gcggggcgcc 2316481 aggcgtacac ggaggcttta gatattaaag aataccacaa gggccgaaca tctattgcgg 2316541 tccttttatt gttttaaaac gacttcacaa gtacagtcac attttctgtc tttatatttg 2316601 gaaacaggat ggaatatgat taagatgaat tgaacgatat tctgcacaat ccgtaagttt 2316661 tcgaggagga ataaaattgc atataaaaat agacgattta actggacgtc aggtggtttc 2316721 actggtgaat gagcatttac atagcatgac gcttatgtcc ccgccagaaa gcattcatgc 2316781 cttaggtcta gaaaaactaa gagggcctga aataacattt tggagcgcat gggaaggtga 2316841 tgaactagct ggctgcggag cgctaaaaga actggacacc cggcatggag aaatcaaatc 2316901 aatgcgaaca tctgcatcac atttaagaaa aggcgttgcc aaacaagttc tccagcacat 2316961 cattgaagaa gccgagaagc gaggctatga gcggttaagc ttagaaacgg gttcaatggc 2317021 ttcatttgag ccggcaagaa aattgtatga aagcttcggt ttccagtatt gtgaaccgtt 2317081 tgcagactac ggtgaagatc caaacagtgt gtttatgacg aagaaattgt gagacggctt 2317141 tataaggata gataagtgca ggggaaggtc tgtcttatct atcttttttt atattcacac 2317201 atttttcacc tttatgatac acgccaatgt tttcaatttt gtttaattca aagaacagcg 2317261 ggaattacaa acgacatgaa cgatatcatg caaattcata aaggaggaga ttgatatgaa 2317321 aagcatagtt ggtgtatatg aaactccgca ggaaaccatc gcagcgattg aaggcttact 2317381 tacaaaaggc tatgattctg atgacatttc tgttgtgaca agccggcgag atacagatta 2317441 tttggagtca cgtacaggaa cagaagtcaa tcaagctatc gatgcacatc aggacgaatc 2317501 tgaatctttt ttcgataaac tgaaagatta tttcacaatg gatgatactg ctacacacag 2317561 caaagcatta tccgacttgg atattaaaac tgatgaaata gacaagtatc aagaagattt 2317621 ggatgacgga aaacttctgg tagccgtcga tacagatgca gatgtaattg ctcctattga 2317681 taacggcaat gccctttcag gcggcttttc aagcacaaat gaattggatt atacaacgaa 2317741 agaagaaaaa acgatgccgc tccgggaaga acagctgaag gtcgataagg aagacgttca 2317801 aaccggcgaa gtagaaatag gaaaagaagt gaaaacagaa aaaagagata tggacattcc 2317861 ggtgagacat gatgaaattt atgtcgaacg ccgtccagtg gatgaaaata aaacggacgc 2317921 tgctcccgtc aacgattcgg aagagatcag agttccaatc gttgaggaaa agctggaagt 2317981 gactaaaaaa ccggttgtca ctgatgaagt ggttgtcggc aaacgcactg ttgaagaaaa 2318041 tgaacatatt tctgaaactg tgaaaaaaga agaacctcgt ctgaataaag aaggaaaagt 2318101 tgacggcttg gatgatgatc cgttaaataa caaatgaaaa tcatagaccg acaacaaaaa 2318161 acctcaaatc ctaaatggat ttgaggtttt tcttttggta cgtcccagga gagattcgaa 2318221 ctcccgaccg acggcttaga aggccgttgc tctatccagc tgagctactg ggacacgttt 2318281 tgtttttttg tttttcgctt taactatcag cgacaagatt tattatatat gggatgcaat 2318341 aataagtcaa cggtttttta gaattttttt catgaggaag aaaattttct tcctcatgac 2318401 attttcatag tgtgactcga ttttgcagat cctcaatttc attgcctgct tggtcgtaaa 2318461 aacggactgt cgcagcatca ttttctaatg tcagtatagc atagctttct gtcctgcgca 2318521 ccctcggaag ccggatgctg cctgggttaa tcatcagttt tccgcgcagc acttcgcttc 2318581 ccgcgatgtg cgaatgcccg aagcagataa catccgcccc gagctcctct gcacgatagt 2318641 atacgtttaa caaggtctgt tttataccgt gaaggtggcc gtgtgtgact agtatttttc 2318701 ttgagccggc agtcagaaga agctcgtcct taaaatcgcc ggcaaaatcg caattgcctt 2318761 ttacaaccgc ataaggctcc aatgcaggat gcctcgtctc aagctcagag tccccgcaat 2318821 gaatcatgag atcaacttct gcctcatgcc gtttcgcaat ggtttggagt tcttcttcaa 2318881 gcccatggct gtcactgata atcagcacgt tcatgtacaa gcttcctcct tatgcctcca 2318941 aaagcttaga cagcttttta agcgcgtcag ccctatggct gattttattt ttttcatcac 2319001 ttgtcagttc agccatcgtc ttatctttat ctttcacgat aaaaattggg tcatagccaa 2319061 agccatattc tcctctcggt tcttcagcaa tatacccttc aacatggcct tcgactgttt 2319121 ttgtttcctc tccgggaata ctcacggcca gtgcgcagcg gaaacgggcg gtgcgctgtt 2319181 ctttttcgat acctttcagc tcgctgagca ctttttcgat atttgcctgg tcgtctttct 2319241 gttcccctgc atagcgggct gaataaaccc cgggtctgcc gccaagatta tcgatggata 2319301 gtccggagtc atccgcaatc accattttgt tcactgcttt ggcaacagct tccgctttca 2319361 taatggcatt ttcttcaaat gtatggcctg tttcttcaat ttcctctgtg aatccaattt 2319421 cagctaaaga tttgacatca tagcctcttg gctcaagaat ttctttgaat tccttcactt 2319481 ttcccggatt atgtgttgca ataattgctt ctttcatgat gatcaagcct ttctgtcttt 2319541 atttcagttc tggcagagaa tcacccagca cttctttttg cttgtcaatc agctcttgga 2319601 ttcctttttc cgcaagaccc agaagaccgt tcagatcctc tctagaaaaa gttgcctctt 2319661 ccccggttcc ctgcaattcc acaaaacggc cgctgcctgt catgatgaca ttcatgtcaa 2319721 cttcagcaga ggaatcttct tcataattta aatctaacaa aattccctgt tccttatcaa 2319781 ttccaacaga gattgcagca agaaaatcag tgatcggatt tgtcttgatt gttcctgctt 2319841 tgatcagctt gccaatcgca atcgccatag caagaaatgc gcctgtaatg gaagctgttc 2319901 tagttcctcc atcagcttga atgacatcac agtcaatcca aatcgtccgt tcaccgagct 2319961 tttccagatc tacaacagct cgaagcgcgc ggccgatcag gcgttggatc tccattgttc 2320021 tgccggaaat tttcccctta gaagattctc tgattgttct ttggtttgtt gcccgcggca 2320081 gcatgctgta ctctgctgta atccagcctt tccctccgcc ccgcaaaaac ggcggtacgc 2320141 ggtcctcaac agacgcgttg cagattacct ttgtatttcc cgctgttatt agaacagaac 2320201 cttccggatg gctgataaaa tccaaatcga atgtgattgg acgcagctca tcgtgttgtc 2320261 ttccgtcatg tctcatgttt tacctccgat tgtatgtaca taaaccattt ttgtcccgga 2320321 attgaataaa gaaagaggca gccggaacgc taacctcttt cttcctagta tatcaaaaat 2320381 cccaatttaa aaactacccg tattcacttg agatggtctg gagaccggtt ctgtgagctt 2320441 ttcgcctttt tcatttacca gctctgattt tccgttcact ttaacagaga cgctttttac 2320501 atccggctgc tccgttaacg tcagcacaat gctgttcagc acttctgaag aaatcatttt 2320561 cgtcttctca tcggcgctgc cgaatataga ttgattgaaa tccaacgtca cgcgcccgtc 2320621 tttgattttc ggtttgctga ccagctttac atcttcactg aagtctgtta acagcccgct 2320681 caccttgctc ggccctttag ccaattcatt aatggctgct gtgatgtcgt ctttttccga 2320741 attgtcgatt cgtttggtca ccggcacgta gtattcactg tcttcatttt ccgccaaata 2320801 gtagactgtc agcggatggg tagcagtgag atcatttaca ccggctgttt ccaaattaat 2320861 gccgtctttg cggcttaaat catctgagat cggcgtccct cctacaggca tctccttcag 2320921 ttcatgcccg tttattctca gcttcacttt atctatcgaa ctaaattgcg tcagcgtcca 2320981 cgtcacagat tgaacgattt tctgttcgtc ttctttctta taatttttga actcattaga 2321041 gaaatcagct atcgccgttc catctttttt gatgtcaacg ttaacggtgg tgtcagccgg 2321101 caatacagct ctgaagccat tcggaagaat ttcagacaca ggcccgccct gtacgaggta 2321161 ttcaagcgcc tgcttagccg tgctctcact tttaggaaga ggcagcgttt gcgcaacaac 2321221 atacccgttt ttatcaatga gataaagctc cctcataaca gtagatgagg cttgatccgc 2321281 ttttgcggta tcgctttttt cactttctgt ttttttggct gctgttgtat ttgaattggc 2321341 acccgcttca tcgttcacga atgtaacgtc ttgaggcgga tcaatttcct cggctgcctt 2321401 atcagattga aacaaaccgc atccggataa aagcaaggca gaggtgagac aagtggcacc 2321461 aatgactgca ggtccttttt tcagcatact tttccctcct aaggatgttt gtactattat 2321521 gtatacgagc ctctttagga aatagaccga agaattccgg caaaacagaa aaaaacccgc 2321581 aacataccgt tgcggggaaa actatctttt aatcggttct tgcagtgaga tacattccac 2321641 atgcccgact tcatggccaa accaatcgtc tgcgattttt gcaaactgat cacgcgcccc 2321701 tgttgtcagg aactgatgat ccggggcaat cggagactgg ttcagcagcc ctttataaga 2321761 gagaattgtg ctgacttccc gggctgtttc atcgccggac gaaataatgt ttacgtgctc 2321821 tcccatatat ctttgaatgg cttcttttaa aatagggtaa tgggtgcagc ctaaaatcag 2321881 cgaatcaatt gatgtgtctt ttaacggata cagcgaggtt ttaacaatct cgtctgctgt 2321941 tttgtcgaga aacttcccgc tttccacaaa aggcacaagc agcgggcagg caaggttttc 2322001 aaccttcaaa tcagggttta atgccaaaag cgcttcttcg tatgcattgc tcttaatcgt 2322061 attctctgtg ccgatgacac cgatatgctg attatccgtc acttttatcg ctgctctcgc 2322121 accaggctgg atgactccga ccaccggtat accgacgctg cgctggatgt catccaaagc 2322181 gatcgctgtt gctgtattac aggcgatcac gagcattttg atgtggtggt tttcgagtaa 2322241 ataattcgtc agctcccacg tatattgaag cacctcttct tcagggcgcg gcccgtaagg 2322301 acaccgtttc gtatccccga cgtagataat attttcttta ggtagctgtc tcatgatttc 2322361 cttcgcaacg gttaaaccgc caaccccgga atcaatgact cctattggtt gttccaacaa 2322421 aatcgcctca ttttctcttc atttcatgct gcagtttcat caaagatttt tcgaagatgg 2322481 ctatttcttc atctgtaaac gattcgaaca tatcacgcag atattcctgt ctttttgtaa 2322541 tgacctcttg gataatccgt tctccttcag gcagcagatg tatcctgaca acacgtctgt 2322601 ccgccgggtc cttgacccgc tcaacaagct catttttttg catgcggtcg attaagtccg 2322661 ttgtcgtgct gcatgccaga tacattttgc ccgataattc accgattgtc atatctccta 2322721 attcataaag ccattgcaag ccgacaaatt gcggcggcgt aatcgcatat tggttaagga 2322781 tttctcgtcc tttttgctta atgatcgcgg caatgtggcg gagtgacttt tcaatatccg 2322841 caacatgctc caaaggtttt gatgtcattt gtccatccct cactcaagga tctcttacgc 2322901 acaaaagcgt tccgtgtcta ttttccttct tttttgaaga aaatgcaaga ctcgcaggag 2322961 agaaatagag gactttagtc aaacaacatc aagaaataaa atttaattta tgacttgcct 2323021 acgttttgca cagcattcca aatatggttt cgaatgttcc aaacaaacag caataaccgg 2323081 ctccttccaa aagaaggaat accggcaagg attaaagctc tagctcaccc attctaagaa 2323141 gctcaacaac ggcttgcgaa cgccctttca cacccaattt ctgcatggca tttgaaatat 2323201 ggtttcgaac ggttttctca ctgataaata gctcgcttgc aatctccttt gttgtcttat 2323261 cttgaacgag caattcgaac acttctcttt ctcttttcgt tagcagcggc ttcgattgaa 2323321 attctttctc cttcaagtat tgtaaccctc cttgctaagg tgagagcgaa tcagaaacga 2323381 atgggttttg atatagtcga gatatcatat gtaagaaggg cgcaggaggt gacgtttaca 2323441 agataattag tttatcgtgt atgaagaagc gtttctttct cctcatccgt ccagctgaca 2323501 gccttgccgc tttcctttga gacttgaacc atcacgactg ccccggtgaa gcagggttcg 2323561 ccttcgaggt tctctccgag atagtgcaag gtaagagatg aactgccgac tgcgcttgtt 2323621 ttcacataga tgcgcaactc ttcataaggc atgacttggc gcaaataatc gcattgctgg 2323681 cttgccacga ctgtcatggt ctgtttgttt tcactcatca tattcagctt tttaaaataa 2323741 gaaatccgca cctcctcaaa atatataaaa ggggttacat tattcatatg cccaaacatg 2323801 tctgtctcgg aaaatcttac ggatacctta ttgaaaaaag aaaaggatgt tttccattct 2323861 tgaaacggca tatcaatata agcgggaagc ttcatctttt ttcatctcct tattgtttaa 2323921 aaaaacctct cccatgcgga agaggttttt tcttcttata ctctgtcgct tccgaagaaa 2323981 ttgcggaacg cttgtaagtt tgtatctcta ttcaaggctg caatcgaagt ggtaagcgga 2324041 atccccttcg gacaggattg aacacagttt tgcgagttgc cgcaatctgc aaggccgcct 2324101 tcatccatta atgcttctaa tcgttcagat ttattcatgg cgcctgtcgg atgcgcgtta 2324161 aacaggcgga cttgcgacat cggtgcaggc cccatgaact tcgatttgct gttcacattc 2324221 gggcaagctt cgaggcagac gccgcatgtc atgcattttg ataattcata tgcccattga 2324281 cgacgttttt ccggcattct cggccccggt cctaaatcgt acgtaccgtc aatcggtatc 2324341 cacgctttta cttttttcaa tgaatcaaac attctgctgc gatcaacctg caaatcacga 2324401 acgactggga atgttttcat tggttttaaa cggattggct gttcaagctg gtcaataagc 2324461 gccgtacaag actggcgggg ttttccgttt ataaccattg aacatgcgcc gcatacttcc 2324521 tcaagacagt tcatatccca tgtgacaggg gttgtcttct cacctttgac attaaccgga 2324581 ttccggcgga tttccatcag agcggaaatg acgttcagat tcgggcggta tggaatctca 2324641 aattcttcat cataaggcgt gctgtcagct gtatcttgac gtgtgataat aaatcgtatg 2324701 gttttttgtt cactcatgat tatttcgcca ccttcttctt cgagtaatcc cgtttccgag 2324761 gcgttatcag tgatacatcg acatcctgat actcaaattc cggcgcttca tacgggctta 2324821 catgtttagc cattgttgtt ttgagccatt catcatcatt acgttcagga taatccggtt 2324881 tataatgggc gccccggctt tcattacggt tgtatgcgcc aagggtaatc accctcgcaa 2324941 gctgaagcat gttcgagaac tggcgtgtga acatcgctcc ctggttgctc cattttgtcg 2325001 tgtcattgat gttgatcttt ttgaagcgct ccattaactc ctgaattttg tcatccgttt 2325061 tcaaaagctt gtcattatgg cggacaaccg ttacgttcgc cgtcatccac tcaccgagct 2325121 ctttgtgaag aacataggca ttttcggttc cgtccatact cataatatca gcccattttt 2325181 cttcttcttt cttaacgtga gcgtcgaata aagatgaaga catgtcttcc gctgaagatt 2325241 ctaagccgtt tacatatttc accgcattcg gaccggccac catgcctccg taaatcgcag 2325301 acagcaggga gttcgctccc aagcggttgc cgccgtgcat agaataatca cattccccag 2325361 ccgcaaacag tccagggata tttgtcattt gatcgtaatc cacccataaa ccgcccatag 2325421 aataatggac cgccgggaag attttcattg gaagcttacg cgggtcgtct cccatgaatt 2325481 tctcataaat ctcaatgatg ccgccaagct taatatcaag ctctttcgga tctttatgag 2325541 acagatcgag atataccatg ttttcaccgt taataccgag cttctggttc acacacacat 2325601 caaatatttc gcgtgtcgca atatcacgcg gcaccaggtt tccgtatgcc ggatattttt 2325661 cctccaggaa ataccatggt ttgccgtctt tatatgtcca cacgcgcccg ccttcaccac 2325721 gcgctgattc actcatcagt cttagtttgt catcgcccgg tatggctgtc gggtggattt 2325781 gaatgaattc tccgtttgca taatacgctc cctgctgata aacgattgac gcagcagatc 2325841 ctgtattaat catggagttc gttgattttc caaagatgat tcccggtccg cccgtcgcca 2325901 taatgacagc gtctgaacgg aaggattcaa tttgcatgtt tgtcaggttt tgtgcaacaa 2325961 ttccgcggca ggttctgtca tcatctaaaa cagcgccaag gaattcccag ccttcgtatt 2326021 ttgtgaccag acccgcaact tcgtatctgc gcacttgctc gtccagtgcg taaagcagct 2326081 gctgtcccgt cgtcgcacca gcataagcag ttctgtggtg ctgtgtaccc ccgaatcggc 2326141 ggaaatcaag caggccttca ggcgtccggt taaacatgac gcccatccgg tctaataagt 2326201 ggatgatcga aggcgccgct tcacacatcg ccttgaccgg cggctggttg gcaagaaagt 2326261 ctcccccgta taccgtgtca tcaaaatgtt cccacggaga gtcaccttcc ccttttgtat 2326321 tgaccgctcc gtttatgccg ccttgcgcac aaactgaatg agaacgtttg acaggaacga 2326381 tggaaaacaa tttaaccgcc attcctgatt ccgctgcttt aattgtcgcc atgaggccgg 2326441 caagaccccc gccgactacg ataatgcttg attgactcat gatagcccct ctccctctag 2326501 taatctagta ctcttaaaca aatgcaaaaa tcgcttttaa gcctacgtat gacagtgcaa 2326561 caaaaataat cagcgtaacg tatgtcgaaa ttctttgaga acgaggcgtt accgtgatgc 2326621 cccatgtaac agcgaaagac cataaaccgt tcgagaagtg gaaaattgtt gataaaacac 2326681 cgacaatgta aaaaccaagc atagccggag agctcaaaat attcgccatc atgtcgaaat 2326741 tgacctcagc acccatttgt gcggcaatgc gggtttccca cacgtgccag ctgacgaaaa 2326801 tgagggtgat gataccggtt acacgctgca ggacgaatag ccagtttctc atgtagctgt 2326861 attgaccggc gttatttttc gcagtaaacg ctatgtacac accataaact gcatgataaa 2326921 ttaatggtaa gaagataata aaaatttcca aggcatacct gaaaggcagg ctatccataa 2326981 aatgagcagc gctattgaat gcttcagcgc cccttgcggc aaactggttg acgactaaat 2327041 gctgaataag aaagatgccg accggtatga cgccaagcaa ggaatgcaat cttcgaaaat 2327101 aaaactctct gttcccagac attactttac cccctgtttg ataagtgcga aatgtgctaa 2327161 atctcttccc ccacttcttt caattgtaag cactttatta agatttattg acaatttcat 2327221 tttactcctc cctcaaaagg gcgtcaagaa aacgcgtaca taaattataa ttttccgaat 2327281 tgattagttg attgaaaaat tttattttat caatatatat ttcttgctta atttttcata 2327341 agaattacag gatcattctg taatcctccc ccctgtttga gctataatat acgcaggaga 2327401 gaggggagac agatatgaag tctaaatttg aagcatctat tgacaaccta aaagaaattg 2327461 aaatgaacgc ttatgcctac gaactaatac gagagatcgt tctcccagat atgcttggcc 2327521 aagattactc ttccatgatg tattgggcag gaaaacatct cgcccgtaag tttcctcttg 2327581 aatcatggga ggaatttccg gccttctttg aagaagcggg ctggggaacc ctcaccaacg 2327641 taagcgctaa aaaacaggag cttgaatttg aacttgaagg gccgatcatt tccaaccggc 2327701 ttaagcatca gaaagaacct tgctttcagc tggaggctgg ttttatcgct gaacaaattc 2327761 aattgatgaa tgatcagatt gccgaatcat atgaacaagt gaaaaagaga gccgataaag 2327821 tggttctgac tgtgaaatgg gatatgaaag acccagtgta atcaaaaagg cggtgactgc 2327881 atagtcccgc ctttttgatt gtcattacac agctgaaggg tgttttgaaa gctcaaatgc 2327941 atcgtgaagc gactcgactg ctttcaccat gtcattttcg cttacgactg ttgacacttt 2328001 gatttcagat gtgctgacca ttttgattaa aatgtttttt tgcgccagta cagcaaacat 2328061 ttcagccgct acaccgggat ttgagaccat gccggatcca acaatagata ctttagccaa 2328121 tttgctttct gtctcgattt tctcaaattc cagcgcgtct ttatactctt caagcaccgc 2328181 aacggtttgg tctgcatctt ctgttttgac agagaaggaa attccagtct tgtcctcggc 2328241 ctgcgtttgg ataatgatat ccacgtttat gtttcttttg gcaagtgttg taaaaatagt 2328301 agacaaagtt gtcaggccgc tagtcagccc gtaaatggtt actcttgtga tttgatcttc 2328361 aaatgcaatg cctctgacaa ttaaattctg ttccatggat gattcctcct caattaatgt 2328421 tcccgcttcg gtttctgtac ttgaacgcac ttctaacggc acttggtaat ttttcgcgaa 2328481 ctcaactgct ctcggatgaa gaacaccggc gcctaaattg gcaagctcaa gcatttcatc 2328541 gtatgagatg ccctcaagtt ttctcgctga tttcacatag cgcggatcgg ttgtaaacac 2328601 gcctggcacg tctgtgtata tgtcacattt atcagctttt aaagcggcag ccaaagcaac 2328661 tgctgttgta tctgaaccgc cccggcccaa tgtcgtaatt tcacaatcct ctgtcatgcc 2328721 ttggaatcct gcaacaatga caatttttcc tttttcaagc tggtctgcta aaaccgaagt 2328781 gtcgatatct gtaattctgg cgtttccgtg aatggcctcc gtacggattc ccgcctgcca 2328841 gccagtataa gacacagcgt catagccttt ttcctgcaat gccattgaaa ggagtgaaat 2328901 cgtgacctgc tcgcctgtcg ccagcagcat atccatttcg cgtttgctcg gctggtcaga 2328961 aatagctttt gcaaggctga ccaattcgtc agtggatttt cccattgctg aaacgacgac 2329021 aacgacttga tggcctttct gtttttctgc aattgcgcgg tttgccgcat tttgaatttt 2329081 ttcgactgag ccgacggaag tgcctccgaa tttttgtaca ataagaccca tgtattacca 2329141 ccctttacat tttggttcgt gcgggtgagg agaaagagcg ctttgtccac aataaaaaaa 2329201 gcaatgagag gaatactctc attgcttatc aattaatcat cataaatgat tatgaacaac 2329261 gagatagccc tccaagaaaa tgatttcttg acagccttac atttattcaa tgcacggcca 2329321 gcaaataata ccgatggggt tttatttgct tcggcgacgc tcccctttca gcctttttca 2329381 cagaatccat ctttctccaa aggcatactc ttgaagttcg cacctctatc ttcaccatat 2329441 aacacgatct aactatgaaa ttagttcaca ttttatcaga tcttatttaa aaggacaaca 2329501 ttatttttgc aatttgtcgt aaaggagctg agccgccgct gcgggaacac cggctttttt 2329561 gatgtcctca aggcttgctt ccttcatttt tttaacggaa ccgaaatgct ttaacagcat 2329621 tttctttctt ttctctccga tacccgggat gtcgtccaaa acggattgaa acgcgctttt 2329681 tccccggatt tgcctgtgaa aactgattgc aaaacggtgc acctcgtcct gaatgcgctg 2329741 caggaggtaa aattcctggc tgtttcgttc cagatacgcc acctccagcg gatcaccgat 2329801 cagtaaattt gaggttctgt gtttttcatc tttcgctaaa ccggcgatcg ggatatccaa 2329861 gccgagttca ttttcaatga catcccttgc tgcgttgatc tgcccttttc ctccgtcaat 2329921 gataatcaga tcgggcagcg gcagattctc acgaagcact ctcgtatagc gtcttctgac 2329981 aacctctctc atagaaccgt aatcatccgg ccctgtaaca gttttgattt tatatttgcg 2330041 gtattccttt ttgtatggtt tgccatcgat aaacacaatc atcgcggaaa ccgggtttgt 2330101 cccctgtata tttgagttat caaacgcttc aattctgtgc ggcgtataaa tatttaatgc 2330161 ctcacctagt ttctgcactg ccccgattga acgctcctcg tcccgttcga ttaaagagaa 2330221 tttttctttc aatgcgattt tcgcattttt atgggcaagc atgagcagtt cttttttcgg 2330281 gccttttttc ggctggtgaa cgtttgtttc cagtagctgc tcgatcatag attgatctat 2330341 gctgtccgga actaaaatct ccttcggaag gaagtggttg ttttttgaat agaactgccc 2330401 gatgaacgtg aggaactctt catctgcttc ctgataaagc gggaacatgc tgacatcgcg 2330461 ttcaatgagc tttccttggc ggatgaaaaa gacctgcacg cacatccagc ccttatcgta 2330521 cgcgtacgcg aacacatcac ggtcgactag atcgttcatc gtcatttttt gtttttccat 2330581 cgttgattca atatgggcaa tttggtcacg aagctctttt gctcgttcaa actcaagatt 2330641 ctcagcagct tcatgcattt tctcttcaag ctcttttttg acctcattat agccgcccct 2330701 taagaaacgt gtaatgcttt caaccagctc tctgttcgtc tcttcggaaa tatcctttac 2330761 acacggagca aggcattggc ccagatgata gtaaaggcac actctgtccg ggagcttgga 2330821 gcattttctg agaggataca gacggtcgag cagttttttt gtttcccttg ctgcctgtac 2330881 attcggatac ggcccgaaat agcgcccttt gtcttttttg acattgcggg tgacaatcag 2330941 ccttgggtgg cgttcatggg tgagttttat gaaaggatag gttttgtcgt ctttgagcat 2331001 gacgttgtat ttcggatcat gctttttgat cagattcatt tctaaaataa gcgcttcaag 2331061 attggaggac gtcacaatat attcaaaatc ctcgatttcc gtcacaagcc tttgggtttt 2331121 cgcgtcgtga gaaccggtga agtaggagcg cactctgttt ttcagcactt ttgctttccc 2331181 tacgtagatc acagtctgct gccggtcctt catgagataa caacccggtt gatcaggaag 2331241 gagggcgagt ttttctttca gttgtttgtt catatgttac ccttccttat gtttaatcct 2331301 ttatttccag tttaacacga acgtttgttt ttctctatgg ttcacaattg gcgaataaaa 2331361 aaagcgatcc ctcaatcgga atcgctctgg catgtaagca gcggaaaatt aaagatgttt 2331421 gtttacaagc tcttgaagcg cttcttttgg tttgaagccg actgaagttt caactacttc 2331481 gccgtctttt aacacaagaa gagtcgggat gctcataacg ccgtattttc cggcagtttc 2331541 ttggttttcg tctacatcga tttttacgat tttcagtttg tctcccattt cttgatccaa 2331601 ttcttcaaga acaggtgcaa tcattttaca aggtccgcac caaggagccc agaagtctgc 2331661 cagtacgacg ccttcgcttg tttcagctga gaaagattga tcagttgctt ttacgatagc 2331721 cattattgaa ttcctccaat gtgaaatgat gatttttagt atagcatctc ccattcgttc 2331781 acgctatttt aatgcttaca aattattttt tcctgatcac agccggttta ctcattttta 2331841 tatggttgaa tgggatatgc tcttttttta aaacacaaat ctgataatgg ccccgatcac 2331901 tacaattgcc ccaataatca ttaaaatggt acgaagcata agatcacatc tcctcttcac 2331961 tgtcatgtac tttaccatgc cctgccggag ctgttttaaa acctgaaaaa gagcgccggc 2332021 atgaagctcc ggcgctcttg cgcgattaag aatcagcacg cagcgtaagt aagacgactg 2332081 acattggcgg gagttttact ttcagtttgt ttttgctgag cgtgtattgt ctgaaggatt 2332141 ccggtttgac atgatgagga tcgtcaaacg tgttatgcgc attcattttt tctgccgtaa 2332201 gaatgactcc ggaatggtcc gctgccttgt gtaggcccct cagctcgatt tccgcctctg 2332261 ctttgttttg gtgatcgatg ttgcaaattg tgatattgat atcgccttca gcttgtttcg 2332321 acgctgaaat gctgatttgc ggaagcgttt caccgttcca ttcatagtcg gcagacattg 2332381 tctctgtggc taaaagagaa gcgtcctggt gcaccttaaa catattgaat acatggtacg 2332441 tcggtgtcaa aagcatccgc tctccctcag tcaaaatcat cgcttgaaga acatttactg 2332501 tttgggcgat gttggccatt tgcacccggc ggcaatgctg atggaaaatg tggaaatgag 2332561 aagccgccac cagtgcatca cgaatggtgt tttgctgata taagaaaccg ggattcgtgc 2332621 ctggctcggg atcaaaccac gtgccccatt catcaataat cagcccgacc cgctgctccg 2332681 gatcgtaccg gtccataatc gtgccgtgtt tttgaatcaa ttcatcgatg tatttggctt 2332741 ttttcatcgt aataaaccat tcatcttccg tgaattctgt ggctgatcct ttgcccttcc 2332801 agaaatcccc cggaatcgtg taataatgaa gactcaaccc gtccatcagg ccagcggctt 2332861 ttttcataag cacgtccgtc caattaaaat catccacatt tgcgccgcct gcaattttat 2332921 aaatgtcatt cccgctgtaa ttgcggacat aagtctgaaa acgccggtac agatctgcgt 2332981 agtattcggg atgcatgttg ccgccgcagc cccagttttc attgcccacg ccgaaatatt 2333041 tcagcttcca aggctcttct cttccatttt gctttctcca gtctgacatc ggcgtgcctt 2333101 cttcaaatgt catatactca atccactccg acatttcctg aacggttccg cttccgacat 2333161 tgccgcaaat atatggctcg cattcaagca gctcgcaaag catcataaat tcatgcgttc 2333221 cgaattcatt tgattcaatt gtaccgcccc agtgagtgtt cagcattgtc ttacggtcac 2333281 cgacaccgtt tgcccaatgg tattcgtccg caaaacaccc gcccggccac ctaaggacag 2333341 gaatgtgcag ctgtttgagc gcctccagca cgtcctttcg tatcccgttg atattgggga 2333401 tgtctgagtc cgttccgacc cagatcccct cataaatccc tcttcctaaa tgctcagcaa 2333461 aatgaccgta tatatttttg ttaatggttc cttttgcgat atctgtttga atcactgctt 2333521 gatgttcaga catgcctctg atcattcctt tcatacggat atgaaaagca ccacagtcaa 2333581 atatgtgatc tgtcgtttgc ctgaggagtc agcatgaatg taagcgcttt taaagtaacc 2333641 atattatata tgttcgtaca tgtcaacgac attttctatt gtttttatat ttgtacgtat 2333701 gtatttataa atatgaaaaa acccggactt ttaaagtccg ggatttcctt tatgagtgta 2333761 tattcagctg tttgaattcc tcagttaata acgggacaac ttcaaataaa tcaccgacga 2333821 tgccgtaatc cgctatttta aagatatcgg cttcggggtc tttattgatg gcgacgatca 2333881 ccttgctgtt tgacatgccg gccaaatgct ggatggcgcc ggaaatgccg catgcaatgt 2333941 acaaatccgg agtaacgact ttcccggtct gcccgatttg gagagcataa tcgcaataat 2334001 cagcgtcaca tgccccgcga gaagccccga ctgcggcccc tagcacctct gcaagctcct 2334061 gcagcggctg aaatccttcc ttgcttttga ctcctcggcc gcccgcaacg ataattttcg 2334121 cttcggagag atcaacaccg tccgccgttt ttttcacgac ctcttggata acagtgcgga 2334181 ggtcagtaag agaaacatca atgctttcga tgctccccga tctgctggtg tctttttctg 2334241 aagcttgaat gttattgggg cgaattgttg caaagatcat cggatcggtt gaaatgacgc 2334301 gttcaaaagc tttccccgag taaatcggcc gtgtgaacac aacattccct ccggtaacgc 2334361 ttacatctat agcatcagaa attaagcctg tttgcagacg ggcagcaagc ttcggtgaaa 2334421 gatccttgcc cattgccgta tgcccgaaga tgactgaatc aggattttct tgctcgataa 2334481 cacctctcat gacctggctg tacccgtctg ccgtgtatgt tttcagcttc gggtcctcag 2334541 cggtaagaac tttatctgct ccgtaatgaa taagctcttg tgcaatgctt tgtacatttt 2334601 caccgatgag aacaccgatg acttccccat ctcctgaaat ggttcttcct gcagctattg 2334661 cttcaaaggt gacatttcgc aattccccat cgcgtatttc tccaagcacg atcacttttt 2334721 ttcccattct aacatccccc tgtttctttg aatgtccaag ttttaaatga ctttagcttc 2334781 gctgcggagc aatgaaacaa gctcttttgc ctgttcagca ggctcacctt ggagaagctt 2334841 cccggcttct tttttcggcg gcagaaaacg ttcaatggtt ttcagctttg gttcagcatc 2334901 ctcttcgtcc agatcaagat catcaagttc aagctcttca agcggctttt tcttagcctt 2334961 cataattccc ggaagcgatg gatagcgcgg ctcgtttaag ccctgctgag ctgtgacaag 2335021 caatgggagc gtcgttttga ttttttcaac atccccttcg acgtcccttt ctgcttctgc 2335081 atcagtgccg ttgatttcga gtttggtgat cgtagtgata cacggaatgt ccagtagctc 2335141 ggcaagccga ggcgccactt gtcctgatcc tccgtcaatg gcaacatttc cgccgagaat 2335201 caaatcaaac tcctgatcct tcatatagtg gtataaaact tgagaaatgg aatattggtc 2335261 gggttcatca agatcatctt ctatgttgat taaaacagct tggtcacaac ccatggcaag 2335321 cgccgtacgc aattctttct ccgcttcttc accgccgacc gtgacagcgg tgatcgtgcc 2335381 gccatgcttt tccttcagct ggatggcttc ttctatcgcg tactcatcat atggattaat 2335441 gatccattcc gctccgtcat cctgaatctt tcctgtttca atgacgattt tttcttctgt 2335501 gtcaaacgtc cgtttcatca gtacaaatag attcatgatc atatcccctt ttattcgcct 2335561 ttgaactgag gctttctttt ttcgagaaat gcctggatgc cttccttggc gtcctctgac 2335621 tcaaatgctt ccccaaatcg ctttgcttca agctttaagc tgccttcata ggaatacacc 2335681 ttgttggaat aaagaagttc aagcaaagat gccagcgttt gcgggctttt ctctgcaaac 2335741 ttagcggcaa gtgcttttgc tttttcaatc acttctgcct catctttcgc tccaattgag 2335801 acaagtccga gatcaagcgc ttcttttccg gatatcggtt ctcctgatcc gatgagctcc 2335861 agtgctttgg ctgtaccgac atatctcgga aggcgctgtg tccccgcaaa acctggaatg 2335921 ataccgagat taagctccgg gagccccagc ttagcatctt ctgccgcgat tctgatgtga 2335981 caggccattg caagctccag cccgcctccg agagcagcgc cgtgaatcgc tgcgataatc 2336041 ggttttggaa aactttcgat tctctccatt aactgctggc cgcgctcagc gagcaatgag 2336101 gaatcctcat tgcctttaag cgatgtaaat tctttaatat cagcgccggc tgagaaaaat 2336161 cttccctcgc cgtgaatgat aatgcttcgt acgcctgcat ctgtctcaca ttgatcaaga 2336221 caggaagaca gctcttctaa tatccggctt gaaagcgcgt ttgccggcgg attgtgaatc 2336281 gtcaagactg ccacaaattg atcaaccgca agtgaaattg cattcatagg acagaactcc 2336341 tttacttatt gtgaattccg gataccaata attctaaaac gctgtttgaa agcgcaacga 2336401 gatcgtactt ttggtcattc atcacccaag ttgtcacagt ttcgtcaatc gttccaaaaa 2336461 tcatctgccg ggcgaggcgg acatcgaggc cttcttttat ttcgcctgat tgtatacctt 2336521 ccgtcaaaat gccatccaaa atatttaagt agccttttaa tatttcgttg attttttggc 2336581 gcagctccaa gttggattgg cggagctcaa gctgcgtgac aatggcgaga ttatggtcac 2336641 ccgctaaaag ggaaaaatgc tttgaaatca caagcgccaa tttctctttc gctgttgctt 2336701 tttctttaat gtcctcttcc atccgctcaa taaattgacc cattttttct ttgaaaagag 2336761 aaattaaaat atcttctttg tttttaaaat agagatagat ggtgccgtcc gctaccccgg 2336821 cttgtttggc aattttggat acctgtgact ggtggtagcc gttttctgca atgacttcta 2336881 ctgctgcatc aataatctgc atatactttg gccgtttttg cttcaatgtt catcgttcct 2336941 tcctatagaa atgaatgact attcattcat aatttcatga taagaaggat tttcaggttt 2337001 gtcaagttta ttcataggcg ttctcttttt ttatttgata tgatgatttt cggtttcttc 2337061 ttcaagtaaa cgccttctta aaatttttcc caccgccgtt ttcggcagct cctttctgaa 2337121 ctcataggct ttgggcacct tatagggagc tagacgtgat ctcgcaaaag cgtccagttc 2337181 ttctgtatcg gcttttgcgc ctttctttaa tacgacaaat gcttttactg tttctcccct 2337241 gtaggaatcg ggaacgcctg cgacaacaat ttcctggatg gcttcatgtt cataaagcgc 2337301 ttcttctacc tcacgcgggt aaatattgta accgccggca atgatgatat ccttcttcct 2337361 gtcagcaata tagaaaaagc cttcttcatc catatagccc atgtccccgg tgaacagcca 2337421 gccatctctc agcactgcgg cggtttcctc tggtttattc cagtatcctt tcatgacttg 2337481 cggacctttt acaatgattt ctccatgctc atacggagcg gcaagctcac ccgtctcttc 2337541 agaatagatc gcagcgtccg tactcggcca aggacagccg atactgcccg gcttgttttt 2337601 tccccagata aagttggcgt gcgtcactgg ggatgcctca gacaaaccat agccttccac 2337661 aagctttcca ccagtcacct tttcaaattt ctgctttacc tccacgggga gcgcggctga 2337721 tccgctaaga cagcttttaa tggatgacag atcataatgc tgcaattcag ggtgatgcaa 2337781 aaggccaatg taaattgtcg gtgcgccagg aaagagcgtc ggtttgtgtt tgtcgatgat 2337841 tttaagtgtt tcgagcggat caaacttagg aagaagaatc atttcgaagc ctagtttaat 2337901 cgaatagttc atgactgccg tcagtccgta gacatgaaaa aatggaacga tgcccagcac 2337961 tttttcagcg ccttctttca cgtcatacat ccaagcggcg cacatttcag tatttgccaa 2338021 aatattttgg tgcgtgagca tgaccccttt tggagctccg gttgttcctc cggtatactg 2338081 gaggacagcg atatcatgct caggatcgat cttcgggatt gtcaggagtt cagttttttc 2338141 ctgcttcata caggaagcga acgtgtgaat gttagctgtt ttgtcaaagt cgatatgcac 2338201 tttttgtttt tgcgtcagcg ggtaaagaat atttttcgga aaaggcaaat agtcttttac 2338261 actggttatc aaaatctggt cgactattga taacgttttc atttttattg ccttcgggaa 2338321 aagcaaatct aaggtgatga ttacacttac ctgagcatct ctaagctggt attcaagctc 2338381 atgctcggta taaagcggat tcgtctgcac cacgatgcca ccggcaaaca agacgccata 2338441 ataagaaatc actgtttgcg ggcaattggg cagcataaca gccactctgt ctcctttttg 2338501 caggccattg cactgcaaaa aagctgcaag tttaagagca tccgtcagaa tgtcatgaaa 2338561 ggtgagtttt tttccataaa acgatattgc ggttttatca gggaatcgtg cggcggagtc 2338621 tgtcaggatg gattgcaggg ttttattcgg caacggaagc tcatgcggga tatcgttggg 2338681 atactcggca agccacggct tttgagactg cataaaacct cccctttcga ttttagagat 2338741 ccaccttatc attatagcag atggacggca aaaaaaagaa aaagaaaggt aaatctttct 2338801 ttttctcata atatgaacag atatataaga ccaattaaca aaaagattcc cgctgcggcg 2338861 agcagtattt tcgcaagctt ttccatctat tctccgtccc cttatattcc ggctgccacc 2338921 acaaaagaaa gcccgacaga aatgacaaat gaaataaagc cgacagcccg gttatcattt 2338981 tcgatttcct gatcaatttt aaaccgcgga gtcaaaaact caaaaataaa gtagctgatc 2339041 agaagcataa caaacccgta aacgccccag ccgatcattt gcagcagcga attatgctgg 2339101 gagatggaat gctgaaatac gtttgcgatt cccaaaattt ttccgccggt cgccattgcc 2339161 accgcaagat ttcctttttg aatctcttcc cagtttttat aagccgtcac cagctcaaac 2339221 acagtcaaaa agaggacgag gcagagaacc gcgacactgt aatatgccgc gatttccaca 2339281 agctcgtttt cccaaaaatc actcatggcc atactccctt ttattttagt tcaacaaccg 2339341 taacgcctga tcctccctca cctgcttcac cgaaacggga acttttgacg ctgcggtggt 2339401 ttttcagaag atcctgtacg ccttttctta aagcgccggt tccttttccg tggatgattg 2339461 acactcttgg atatccggct aacaccgcat catccaagta tttttcaacc cggctgaggg 2339521 cattttcata gcgttcgccg cgaagatcaa gttcaagcga tacgtgatag tcctttcctt 2339581 tgaccgctgt aatcattttt tctttttttg gctccggagc tgatttgata aactccagat 2339641 ctttttcttt tactttcatc tttaaaatac cgatttgaac gttccattca ttgccgcctg 2339701 ttttttcgag caatgttcct ttttgcccga aagtgaggac tttcacctcg tcgccaggct 2339761 taaagtcgcg tttttgcgtt ttcggctttt ccggtttctt ggacttttca aaagcaggca 2339821 tagcgccttc taaccgtttc ttcgcgttaa tcagctcgtg atccttgaag gatttgtgtt 2339881 cttcttttat ggtgcgcaat tcatgaataa tgtcctcggc ttctttcatt gccgctttta 2339941 ctttttcagc agcctgctgt tctgcctctt caagcatttt gtcttttttg ctgttaagct 2340001 cgatgatttg ctgctgcagc tctttatgca gtttttccgc ttcttttctg attgattctg 2340061 tctcagaaag ctcttcttcc gcacgttttt tgctttgttc cagcgacgca atcatcgtat 2340121 cgacttcgtt atgctcggcc gtcatttctg acttcgcctg cccgatgata tggtccggga 2340181 gcccgaggcg ttttgaaatt tcgaaagcat tgcttcgacc cggcacacca attaaaagtt 2340241 tataggtcgg tgacagcgtt tcgatgtcaa attcaacgct ggcattcatg acgccttctc 2340301 tgttatagcc gtacgccttc aattccggat aatgcgtcgt agctaacact cgtgcattgg 2340361 tgcgatgcac gtcatccaag atgctcatgg cgagggccgc cccctcctgc ggatctgtcc 2340421 ctgcaccaag ttcatcgaaa agcacaaggc tgttttcatt gacctgttct aaaatgccga 2340481 caatattcac catatgggat gagaacgtac ttaaactttg ctcaatcgac tgttcatcac 2340541 cgatatcagc gaatacgtgc tcaaatactg ccgcttctga cccttcatct gccgggatat 2340601 gaagacctga ctgcgccatt aaggttagca ggcctaacgt tttaagggtg actgttttcc 2340661 ccccggtgtt tggccctgtg atgacaatgg ttgaaaaatc gcggccaagc tcgatgtcat 2340721 tggcaacaac ctgatcaggc ggaagcaatg gatggcgggc ttttttcaaa cggataaagc 2340781 cggtgtcgtt cataatcggt tttgtcgctt taaccgcttt tgcatatcta gcttttgcaa 2340841 aaataaagtc aagcgtctgc agcacttgca aatctagaaa tagctcctct gtatactctg 2340901 ccgttttctc tgtcagcaca cgcaaaatcc gttcaatttc ttgcttttct ttcactttcg 2340961 cctgctgaag ggaattgttc atatctacaa tcgcctgcgg ttcaatgaat agtgtcgcac 2341021 cagaggatga ggtgtcgtgc acaattcctc catagctgga tctgtactcc tgtttgaccg 2341081 ggatcacaaa gcggtcattc cgaatcgtaa caatcgtatc agacagcatt ttcgatgcgg 2341141 aagaggaacg cagcatcgac tctaaccggt ctctgactct tgattcgagt gttctgagct 2341201 gtgtgcggat tcctcttaat gtttccgatg catgatcaag cacttctccg tgatcatcaa 2341261 tgcaggaatt aatgtcccgc tctaaatcgg acagcgtgat aagctgttca gcatgctgat 2341321 ggatcagcgg aatgtcgaca ccgtcttcag ccatttgcgt gataaaatgt ttcatttgtt 2341381 taactgcata aagcaggcct gagatttcag tgaattcaga aggactgaga acgctgccga 2341441 tttccgcccg tcttaacgct cctctgatat ctacaaggcc gccaaatggc gcttggcctc 2341501 tcagccggat aatgtcagaa gcttcgtcta cttcatccag ctgttttttg atttcgtcta 2341561 tagaagcaga aggcttaagc tcgagaagca tttcttttcc gagcgatgaa gcggcatgcc 2341621 caataacctg ttctttcact ttatgaaatt caagagctga taatactttt tgctgcacga 2341681 ttgtgtgagc ctccttactt aatcgttgcg cttcagaaat gcctctacgt ctttaagcga 2341741 ccgggcattc agaacgtttt tcgtttccgt ccatcctttg cgcgcggcag taacgccagt 2341801 tttcatatcg tctaacatct caatattatg ggcatcagta ttaatcacca atgtaacccc 2341861 ttgttcgttt gctttcatta aatgctctgt gcgcagatca aggcgcgcag ggttggcatt 2341921 gagttcaagc gccgtatttg ttttcctcgc aagctcaatc agctgatcaa tatcgatttc 2341981 gtaaccggcc cgtctgccga taaggcgccc ggtcgggtgt gcgataatgt caacatgctt 2342041 gtttgtcagt gccgtctcaa gccgtttcat aatcacgtgt tccggctgat taaaactgga 2342101 atgaatcgat gcaataacga tatccatttc cgcaagcaca tcgtcatcat aatcgagcgt 2342161 accgtcaggc aggatatcca tctcaacgcc tttcaaaata cggaagtttt caaactctgc 2342221 attcagcgcg tcaatttctt ttgcctgctg cttaagtctt tctgcagtaa gcccgttggc 2342281 gacctttaaa tattgtgagt gatcggtgat cgccatgtat tgatagcctt ttttgatgca 2342341 ggcttcagcc atctctctga tcgaaaatgc gccatcgctc cacgttgagt gcatgtggag 2342401 atcacctttg atttgcccga gctctatcag ttcaatgctg tcgctgtagg tttccacttc 2342461 ctgtccgctt tcacgaattt ccggcggaat cagcggcagg ccgaagtgcg cataaaattc 2342521 acgttcactc ggaaatgttt tgatctctcc ggtttcaact gtctcaacgc cgtattcact 2342581 gatccgctcg ccgcgttctt tggcgatttg gcgcatctta atattgtgat cctttgatcc 2342641 cgtaaaatga tggagtgttg tcggaaactg ctcttccgtc acaagacgga aatcgacgct 2342701 tgtttcatat tcaaaggaaa ggatgacgga caccttcgta tctccgcttg cgatcacgct 2342761 tttgatgttt ggcagctcaa gaagctgctc tcttacttca gccggatgat ctgtagcaat 2342821 gatataatcc agatccttca ccgtttcccg cgctctgcgg agacttccgg cacgagaaaa 2342881 tttgatgata tgcgtaaatt gagaaagatg ctcctcaatt tcccgcgcga tccggagggc 2342941 gtagccgatc gggaaccgtt caggctgttt tccggcttcc ccgagcgcct gtaatatttt 2343001 ttcttccgat tttttgccga agcccgcaag accctggacc ttttgctgct cacaggcttc 2343061 cttcagagat tctgcatcgt gtacgccgag ctctttatac agctttgcga tttttttgcc 2343121 gccgagcccc ggcagcttca ataaaggcac gagtccttcc ggcacttctt tctgaagcga 2343181 ttcgagcgtg cttgactttc cttcatctat atactcttta atgacgctgt acgttccttt 2343241 tccaatgccg gacagcgaca tcatatcgtc catttctgat aagcttcggt cgtcctgttc 2343301 cagagctgcc gccgcttttc ggaaggcgga tactttaaac gggttgtccc ctttgagttc 2343361 catatagact gcaatggttt caagcagccg gataatatct tttttatgca tatcataacc 2343421 cccagacgtt cacatatgtt tccatcatac ttgaaaaaaa cttctccgga caagagaagt 2343481 ttttttatgc cccgtactgt gtccacagct cttgtaaaag ccctgacaag tacggtgtat 2343541 ggttaatgat cacatttgcg agagacgatt gccccatcat ttgctgcaac gcgtctaccg 2343601 gcagaacgga tgcgacatac agcagcacaa atgtaaataa atagacttct agaaaaccga 2343661 gaacggctcc cagcatctgg ttgatttgtt taatcaccgg aatgccggct acaatactca 2343721 ggaacgagcc gatgattctc agtaagattt tagcaatgat aaataaaacg ataaacgcaa 2343781 tcgcattata gtacgctgct tccaaattcc ccgtaaaaaa agaaagagcc ggctgtcccg 2343841 ctgaaaaatc gggtgcggga atccaatgta aatgcggtgc cacgttttta tagaataaag 2343901 ccgcaaaggc aattgataaa ataaagctcg tcaagcggat aaactgcagg ataaaaccgc 2343961 gttttaaccc cagtaaagtc cccatcagga gcaagattaa gatgatgata tctagcatag 2344021 ttgttcaatc cttttcttta agctgacgct ccagtttttc acatttctct tgtaatttga 2344081 cataatcgtg caccacattt accgctgtca gcactgcaag tttatttata tcaaggtatg 2344141 gatttttttc attgatttct ctcattttat catcaacaat tccggcgaca tacctcatat 2344201 gggctctgct ttcttcaccg acaatcgtga agtgctggcc gtaaatgtca acggttgttt 2344261 ttgttttttt gccgtcagac aacgtttctc ctccattccg cgagaatcct agttcttatc 2344321 ataacacgtt tattaaatga atggaaagac gagcctcccg ctgttatgat acactggtat 2344381 atacagcgaa aagtgtaaaa aaaggagatt attacgtgtc ccattcagtg ataaaagtat 2344441 cgttgtctgc tattgaccaa atgaaaatga cgtacagcgg ttcacttaca gcctctgttc 2344501 cgcagggagc cgtttttcag gcaaaaccgc ccggctgtac cattacagca tatcaatcag 2344561 gtaaggtctt gtttcaagga aaaaacgctg cggcagaatc cgcgcgctgg ggaacagcag 2344621 agcctcagga aaagaagaaa acggccaaaa agccggctga tccccgctat gcccctccgg 2344681 cagatatcgc cggaatgtct gttatcggtt ctgacgaagt cggaaccgga gattactttg 2344741 gcccaatgac ggttgtatgc gcgtacgtcg acaaaaccat gcttccttta atgaaggaac 2344801 tcggtgttaa ggattctaaa gatttaaaag atccgcaaat catcgagatt gcccgaaacc 2344861 tgattaaaac cattccgtac agcctgctgg tgttaaagaa tgaaaagtat aacagcatgc 2344921 aggaaaaagg catgagccaa gggaaaatga aagctttgct gcacaatcag gcgatcacac 2344981 atttattaag aaaattggat ggagtaaagc ctgaagccat tttgattgac caattcgctg 2345041 agccaggcgt ctacttcaat catttaaagg gcagagacat tgtgaaggag cggacctatt 2345101 ttagcacaaa agctgaaggt attcacctgg ctgtcgccgc tgcttcaatc attgcaagat 2345161 attcattttt aatggaaatg gataaactat cacgcgcggc aggaatgacg cttccaaaag 2345221 gggccggtcc gcacgtcgat gaagcggccg ccaagctgat cctcaaaaaa ggggcatctg 2345281 cactcagaac ctttacaaaa ctccatttcg ccaatacgca aaaagcgcag cgccttgctg 2345341 ataaaaaacg ttcatagaaa aaagcttgca gatttctctg caagcttttt tatcagcctc 2345401 ttaaaacagc ttgatatgtg tcttctaacg ctttcagcac tttgctgtgc gcctttgtca 2345461 cttcttcttc agtcagtgtt tgttcaggat tgacatactg gagtgagaaa gcgactgact 2345521 tcttgccttc ctccatatgc tctccttcgt atacgtcaaa tacggttacc tctttcagaa 2345581 gcttgccccc ggcctcttta atgacgctct cgagctgtcc gcttgtgacg gttttatctg 2345641 ttacaagagc gatatcacgt gtcacagacg gatattttgg aatcgccgtg taaacaagcg 2345701 gtgctgtttc tgctgcgagc aacgcatgaa gatcgagctc aaatacgtat gtttccttta 2345761 tatccagttc tttttccaat gaaggatgga cttggccgat gaagccgatc agagaaccat 2345821 tcaataaaat gttcgctgtt ctgcccggat gcagctgttt gcgttcagac tgtacaaatt 2345881 caatgctgtc taggacgttg agtttgtcta acagcccttc cacaattcct ttgacaacaa 2345941 agaaatcaac tggtttcttt tcaccctgcc atagctgctt gcgccataat ccggtaacag 2346001 ctcctgctac gcgttctgtt tcaacaggtt ttgtgtcctc ttccttcgtt aggaaaacgg 2346061 agccaacttc gtacagtgca actgagtcag tctgcctcgc aagattgtaa gaaacagaat 2346121 caagcagatt tggaacaaga ctgtgtctga gaatgcttct ttcttcactc attggaagcg 2346181 caagcacagt attcagtgat ttttcaatcg caaacgctgt cgctttcttc tcgtttgtca 2346241 gtgagtaagt gatggcttgt gataagcctg cgccttcaag gaagcgtctg actttacggc 2346301 gttttgcctg atatggcgtt aatccgcctg tagttcccgc tgtctcagga agcgtagacg 2346361 gaatgttatc gtagccgtac agtcttgccg cttcttcgat taaatcctct tctattgtaa 2346421 tgtcaccgcg ccgtgatggg acagtcacaa cgagaagatc atccgcttca ccgaccgtaa 2346481 aaccgagacg tttataaatg ctgatcagtt cttctttact gatcgtcagg cctagaacgc 2346541 tgctcacttt gtcagcagat acgtgaatgt tatttgcttc gattgtcagg tgatcttcct 2346601 caaccgttcc agcaagcacc tcaccgccgg catacagatg gatcagctgc gcagcccgtt 2346661 ctgctgcaag acgtacgcgt gccggatcaa ttcctttttc aaatcttacg cttgattcac 2346721 ttctcaaacc aaggtctttg gaagccttgc gaaccttctg cccgttgaaa tacgcagcct 2346781 caagcaaaat ggttttcgta tcttcctgaa cctctgactc tgctcctccc atgacaccgg 2346841 caacggcctg cgctttcgtt ccgtttgtaa tgacaaggtg atcggcagac agcttacgtt 2346901 cttgatcatc aagtgttacg atcatttcat tctcagctgc ttttcttact acgacttcct 2346961 tagagccaaa tctgtcataa tcaaacgcat gaagcggctg tccgtattcc aacaggacaa 2347021 aatttgtgat gtcaacgacg ttgttgtgcg gacgaatgcc tgcattcatc agctttgtct 2347081 gcatccaaag cggtgacgga gcaatcgtga catttttaat gatttttgca gtgtacagcg 2347141 ggttcgcttc ttgatcttca attttgactg aaatgtaatc agacgcttgt tctgaagcag 2347201 ccgggtaatc cgtttgcgga agctttacct cagtgtctaa aatcgccgca acctcgtaag 2347261 caacaccaag catgttcatg gcatccgcgc ggtttggcgt taaacccagc tcaagaatcg 2347321 catcgtcaag ctgtaaagcc gctaaggcat cgcttcctgt ttcagcgtca ttcgggaata 2347381 cgaaaatgcc ttctgcatac tccttcgcca caagtttgct ttcgatacca agctcctgta 2347441 aggaacagat catgccgttt gattcttcac cgcgaagctt ggcttttttg attttgaaat 2347501 tgcccggcag caccgctccg actgttgcaa ctgcgacttt ttgtccctta tccacattcg 2347561 gcgcgccgca aatgatttgt acaggggctt cagctccgat atccacaagg cacttattca 2347621 gcttatcagc attcgggtgc tgctcgcgct ccagcacatg gccgatgaca acgcctttga 2347681 tgccttctcc tttgtattca attccttcaa cctcaatacc ggctcttgta attttttcag 2347741 caagaacagc cgggtccatg ccttttaaat caacataatc ctctaaccat ttataagaaa 2347801 caaacatcct tgcatcctcc tcttacgcct gtttaaactg cgaaataaat ctgacatcgt 2347861 ttgtatagaa gtggcggata tcatcaatgc catatttcag catcgcgatg cgctcaacac 2347921 ccattccgaa tgcgaagccc tgatattcct tcggatcaaa gccagccatt ttaagcacgt 2347981 tcgggtgaac cattccggca ccgaggattt caatccagcc tgttccttta catactgagc 2348041 agccgttccc accgcattta aagcatgtca catccacttc tactgaaggc tcagtaaacg 2348101 ggaagaagct tgggcggagt ctgatttcac ggtcttgccc gaacattttt ttcgcaacaa 2348161 gttcaagcgt tccttttaaa tcactcatgc tgatgttttt gtcaacgaca agcccttcaa 2348221 tttgcataaa ttggtgagag tgcgtcgcat catcgttatc acggcgatat actttacccg 2348281 ggcaaatgat tttaacggga cctttgcctt catgcttttc catcgtacgt gtttggacag 2348341 gagaagtttg cgttctcatc aaagtttcct ctgtgatgta aaagctgtcc tgcatatcgc 2348401 gcgctgggtg ttctttcgga agattgagcg attcgaagtt gtagtaatcc gtttcaacct 2348461 ctggcccttc ctcgactgtg tagcccatac cgataaataa atcttcaatt tcttcaatga 2348521 caacagtgag cggatggcgg ccgccgactg caacagggtt ccccggcagc gtgacgtcaa 2348581 ttgtctgtcc tgcaagcttc tgtttcattt cctcttcttc aagcttctcg tttttgtcag 2348641 caatcgcatt ggcaatacgc tcccttactt cgttcgcgag cgcccccatt tttggacgtt 2348701 cctcagcaga aagcttgccc attccgcgca gcacttctgt aatcggccct ttttttccga 2348761 gatattgcac ccgaatatca ttgacaacct tcaatgagct tgccgcttct acttgttcta 2348821 aagcttcttg ttccagctgt tttagctttt cttccatttt gcatcctcct tttatgtaaa 2348881 caaaccgtca tatgtctttg gaaaataaaa aaaacccgtc ccttgtacaa gggacgagtt 2348941 gtggccgcgg taccaccctt atttcagaca gactgatgct gtcgtcagct tcattgacat 2349001 aacggaatca gattccggtt cacctttacg cgcagtgtac gcggtcccgg cgacaactca 2349061 agaggtgaag ccaatttccg gctgcgttaa aaatgctctc agtcagcggc attttctccc 2349121 tggaaagcag ttgatcagaa attgaggtcc tctgtcacgg tttttgaaat attatgttct 2349181 attatagaga aatccaacgc ttggcgcaac actatcctcg caagtgatac acgaggatgg 2349241 cagccgcaac cgcaacgttt agtgattcag cctgtccgta aagcggcacg tacaggttca 2349301 aatccgtttt ttccagcaat gcagcatcta cccctgcacc ttcatttcct acaatgagcg 2349361 caaaggattc agactgagga atctcctggt aaggcgctcc gttttgcagc gccgtgccgt 2349421 atacttttac gccctctgcc ttcaattcgt ccacatatga aggcaggttt cttctcacaa 2349481 caggaatatg gaagtgagat ccttgagcag atcgcagtgt ttttccgtta aaggcgtccg 2349541 ccgtgccgtc accgagtaca accgcatcca aaccggccgc atcagccgtt cgaatcattg 2349601 tgccaaggtt tcccggatct tgaacagcgt caatcagcag caccttgcgt gccgttgcca 2349661 gcttttcttc aggcatatgg cacacagcgg caatctgctg cggcgtttcg gtttcagtca 2349721 cagctgaaaa cgcatcttca ctcagcatat agcactggat accagtctca agatctgaag 2349781 gaatcctcgt ttcatccttt acaaggattt ctttcacaat gcccgggctt ttcaacgcct 2349841 cttcaacgag gtgttctccc tctatcagaa atgtatttgt ttttgttcgt tctttttttg 2349901 tgtgaagctt tttccaatcc ttcacttttt ggttttttgc cgattctatt tgtttcactg 2349961 tctatgtggc gctccttttt ttaacatgat gttattatat cgcaagaaca gcacataata 2350021 aaccaggtgc agggttagaa tatacgtatt acattttaga aaaaggagcg ttttacatgg 2350081 atcttaattt acgtcatgcc gtcattgcca atgtcaccgg caataatcag gagcagcttg 2350141 agcatacaat cgtagatgcg attcaaagcg gtgaagaaaa aatgcttcca gggctcggcg 2350201 ttttattcga agtcatttgg cagcacgcat ccgaaagtga gaaaaacgaa atgctgaaaa 2350261 cgcttgaagg cggattaaaa cccgccgaat aagacatgaa accgggtgac agcgcccggt 2350321 ttttttctta tataataaaa acatgatgag ggggaacgcc atgtttttac agccgttatt 2350381 agcgaaaaaa attattgctg aagttaaaaa aatgtacgaa cgtgaagtca ttattgtaaa 2350441 cacggacggt cttattatgg caggcacaaa cgatgagcgt gtcggacaat ttcatgaggg 2350501 agcgcttatc tgcgcaaaag aaagacgcag cgtgattatt acaaaagaag atgaaacaag 2350561 gttaaaagga gtgaaagcag gcataaacct ccctgtattt tttgaccatg atgtgattgc 2350621 cgtcttcggg ctgacaggtg agcctgcaga gattcagcca ttcggagaac tgcttcgaaa 2350681 aatgacagaa ctgttcatta aggaatcgcg gcacttagag caatcccagt ggcgtgagag 2350741 aatgctggag tcctttatga tcgattggct gcaattaaag gagtggtctc ccagttttct 2350801 tgagaaagct cagcttcttg gtgttgacct ttcttcccgg cgccaaatga ttcttattca 2350861 ggggtatgag tggtcacctc atgatattga acaaatggca cgcagctgga aatcctcgta 2350921 ccctgcggat ttgttcatca ggtggggaaa tgaacggatt ttgattaatc atgaagtgcc 2350981 gcagcatgaa caaagggatc ggcttttgcg gaaaatcctt cacatttgtt cgtttgccaa 2351041 taccgcaagc agccaatata cagcagctgg cgccggaagg gctgtcgcaa gctccagcct 2351101 gacagattca tacgagcaag cggaaaaagc gctggctgtc agccttaagc gaaaaacgcc 2351161 catatttgaa gaggatctga agcttgatat gtgtctgacg gagatcagcc cgggaacccg 2351221 aaacgaattt ccgcaaagag tattaggaaa ggcgctagag catcaggaac ttatgaatac 2351281 gatacggact ttctttcatc acgatttgtc tttgaaacaa accgctgaag acatgcatat 2351341 acacatcaat acattgcgtt atcgtctggc taaggctgaa cagctgacgg gattacgttt 2351401 tgaccgtacc gaggacgtcg tcacgatgta cgtcgcactc tattttttag atcaagatac 2351461 aaaatagaga gagtttcagt ttcatttttt gtatgtttct ccatggaagg ctttgctttt 2351521 tttcttttac aatagattga aagcgttttt tgacaggggg atgggtgaaa tgatcaccaa 2351581 ggatgtaaag gagcagctga ttcaggtctc cggaccagaa aactttgatg actcgaatgc 2351641 cggccgtctc gtctattcat atgatgcgac gcctcagtat cagtctatgc ctgatgccgt 2351701 gattgctccg aggaatactg atgaaatatc acgcatttta acaatttgca gcgaacatcg 2351761 agtgccgatc gttccaagag gatcagggac aaacctgtgc ggcggcacgt gcccgactga 2351821 aggcggactt gtgcttctct ttaagcacat gaaccagatt cttgaaattg atgaagaaaa 2351881 tttaactgcc acagttcagc cgggcgtcat tacgttggat atgatccggg cagttgaaag 2351941 caaaggttta ttttatccgc ctgacccgag ttctatgaaa atatcaacta tcgggggcaa 2352001 catcaatgaa aattccggcg ggctacgcgg attaaaatac ggtgtcaccc gcgactatgt 2352061 tattggactg gaggttgttc tcgcaaatgg tgacatcatc cgcaccggcg gaaaactcgc 2352121 aaaggatgtg gccggatacg atctcacacg tctttttgtc ggctcagaag gaacactcgg 2352181 cattgtgaca gaggcaatcg tcaaactcgt tccaaagccg gaaacaaaga agacgctgct 2352241 tgccctttat gaaaacatcg atgccgctgc tcaaacggta tcggacatta ttgccgcaaa 2352301 aattataccc gctacgcttg aatttctcga tcagcctaca ctattggtga ttgaggatta 2352361 tgccaaaatc ggacttccga caagcgcaaa agcagttctg ttaattgaac aagacgggcc 2352421 atttgaaact gttgaacggg atatggaaaa gattgaggcg atctgcaaaa aaggcgacgc 2352481 cgtatccgtt cagaccgcac aaacagagga ggaagcgttt gccctgactg aagcccggcg 2352541 ttctgcactt tctgccctag cccgcctcaa accgacgacg attttagagg atgcgaccgt 2352601 tcctcgctca gaaatcgcca atatggttaa agcgattaat gatattgctg ctaaatatga 2352661 tatttccatc tgcacctttg gtcatgcggg agacgggaac cttcacccga catgcacgac 2352721 agacataaga aataaggatg aaatggaacg tgtcgaacag gcttttgccg agatttttga 2352781 gaaagcgatt gaacttggcg ggacgataac cggagagcac ggagtcgggg aaatgaaagc 2352841 gccttacttg gaaatgaagc tgaaaaaaga aggcattgat gcgatgaaag cgttgaaagc 2352901 ggcatttgac ccccggaaca tattaaatcc cggcaaaatg tttgcgaaag atgccagaaa 2352961 acgtgtggtg gcggaaagat gacaacagaa aaagaaatga aacagatcca aaatgaattt 2353021 aaagagcgta tggatgaagg agagttatta aattgtatgc gctgcggctt ctgtcttcct 2353081 tcctgtccga cctatatcga atcgggattt caggaaacac actctccgcg tgggcgcatc 2353141 gccttaatga aagccgtagc cgacggtatg attgaaccgg atgaagatgt cgaacggtcg 2353201 ctgtcacttt gcctcggctg ccgcgcctgt gagcctgtat gcccgtctgg cgtgaaatac 2353261 gggcagctgc ttgaggaagc cagagatatt atccaccaaa ataaaaaaca ctctcttggt 2353321 gaacgtgtca tgcgaaagac ggcttttcac gagctgtttc cgcatcaaaa ccgcatgcgc 2353381 tcagctgtaa gccttatcgg tttgtatcag cgttcaggac tgcaaaccgc tgtgcgaaaa 2353441 tcaggcatgc ttcgggtcct gcctgagcat ttgcggacga tggaagctgt tcttcctgat 2353501 gttccaaaaa gcaaagacat gaaacatcgg ccgcgtttcc tgccttccat tggccccatg 2353561 aaaaaacggg tcgccttttt ttcgggctgc ttaatggata caatgttttt accgaccaat 2353621 aacgccacat tgaagctttt acagctggca ggctgcgaca ttgtcattcc gcctgaacag 2353681 gcttgctgcg gggcgcttca tggacacagc ggtgaaaaaa acacagggaa agagctcgcg 2353741 aaacaaaata tcgctgcttt cgaagcatta gacgtggatg cagtcattac aaacgcagga 2353801 ggatgcggag cctttctcac tgaatatgat catttgctga aggatgaccc tgagtggtcg 2353861 gaacgggctg ccgcttttgt tcaaaagctg aaggattttt cttctgtttt ggttgaactc 2353921 gatttccatc aaatggatct agcactcgag acgcctcagg tcgttaccta ccaagattca 2353981 tgtcatctaa gaaatgtgat gcatacgtca cttgagcccc gccagcttct taaaagcatc 2354041 aaaggggcgg aattcaaaga aatggagaaa gcagacagct gctgcgggtc agcgggaatt 2354101 tacaacatcg tcgaagttga aatgtctatg aaaatactgg acagcaaaat ggctgccgtc 2354161 aaagcaaccg aagcgatcct cattgtaaca gcaaatcctg gctgcctgct gcagatgaag 2354221 ctcggcattg aacgcgaagg actaagcggt aaagtcagag ccgttcacct ggctgatttg 2354281 ctattagaag cagccgggca caaaacatca tgagaaagcc caaaacagac attgttttgg 2354341 gcttttgtgc gttattccat cggactgcaa atttcgatat aatgtccatc cggatcagcg 2354401 atataggcga ccgtctgccc ccatggtttc actttcggct ccccgataat cgatacgcct 2354461 tgttctctca tccttttgat gaccgcttct acattttcag taacaaaccc gatttcaaat 2354521 gtgtttgaag cagatgtatc cggaatgtcc agcgccgtga tgtctctggc gctttcccgg 2354581 gtattaagcg ccaatatcgt agaccctgta tcaaattcga catacgtgcc gtgttcagca 2354641 cgaatcggca gtcctaaaat atcccggtaa aaaatgaata gcccgcttgc tgtccgatac 2354701 gtatagaata agatatttca ttgatagatt cattgccaac ccctctcagc attttcaata 2354761 gtccttctag cccggtatag atgcttccat ccttaagctc ggatctttcc acatctgcgc 2354821 ccattttttc acagccgcca cgataatgat gaagcctaac accagcatga tgatagataa 2354881 tacgccattc aatacactat atcctgctgc ttcaggattg agatacacat tgcgcaccat 2354941 ccaatagccc gcataattga cagtgacata taaataggca agcgggataa ggcaagtcag 2355001 aatgtaccgg cgtttatcgg cgattttcag cacgatcgtc gctccgataa tcagccccac 2355061 tgaagccatc agctgattag aaacgccgaa gagcgcccaa atggaaccga tatctcctga 2355121 atacagcaag tacccccaca tcaaacaggc aagcgcgctg gcaaatacag agcccggaat 2355181 ccagtctgtt ttcttcagcg gcttatacac ctccccgaag aagtcctgga tcaaataacg 2355241 ggcgacacgt gtgccggcgt caatcgctgt taaaataaag accgcttcaa acataatgac 2355301 aaattggaaa aagtatgagg ccaaatggct gaaaaacggc attccggtaa aaatataagt 2355361 catccctacc gcaagcgtga cggctccccc tgttcttcct tctaagtcca aaccgatttc 2355421 cccgctcaat tcaggcaaat gtacgacatt catgccaagc gtacggaaaa cctcaggcgt 2355481 gctgttaatc gcaaagtaat cagcaggctg taaagcggtc gctgcaatca gcgccatgat 2355541 accgacaaga cactcaacaa gcattgcgcc aaacgcaacc ggcttcatat cactccattt 2355601 attcagcatt ttcggtgtcg ttcctgagcc gacaaaggca tggaacccag agatcgcccc 2355661 gcaggcgatg gttattgaga tgaacggcca gacaggtcct gccagcaccg gccctccgcc 2355721 ttttacgaat tctgtaaacg cagggaacgg aatggacgga ttgacgacaa acacaccaac 2355781 aatcaaagcg ataaaaacac cgattttcat aaagctgctt aaataatcac gcggagccag 2355841 aagcagccaa acgggaagcg cagccgcaaa aaacgcataa acaggaagcg cgattgcaag 2355901 cgttttcgta tctagcgtta aaaagtcacc gagcgcggta gtctgtaccc atggaccgat 2355961 aaagactcct gccattaaaa agagaaagcc gaccgttgaa gcgagcttta aatttcccgt 2356021 tttcttataa aataagccca cacccatcgc aatcggaatc gtaatcccca ccgcaaatgt 2356081 tccccatgga ttacgttcaa gcgcatgcaa gacaaccatc gacaggcccg ccattgtgat 2356141 cgtgatgata aacagcatgg acagtcctgt acaaaatcct gcaacagggc caagctcatc 2356201 cttcgccact tccgacagcg attttccgtt tttgcgcatc gatgcaaaca acaccacaat 2356261 atcatggacg gctcccccaa ttaccgcccc gattaacagc cacaataatc ccggcaaata 2356321 gccaaactgc gccgccagaa ttggtccgac cagcggcccg gccgctgcga tcgcggcaaa 2356381 gtggtggccg aacgaaaccc atttatttgt aggcacatag tctttcccat cctcaagcgc 2356441 atgagcaggt gttggcttgt catcattcac tttgagaacc ttcaccatca taaatgttcc 2356501 gtataaacga taggcaatag ccaaaataca cattgatgct atcacaattg taaccgcatt 2356561 cattttctcc catccccttt tctgtttttc ataaatatat cataatttca tggtgaaaag 2356621 cggtcatttt ttcctataca aaaagccggc tggaatgggc cggctcgtgg cagttgaaag 2356681 acaagccgga gagaaatctc cggctttgct attcttatga ctgttttttc aggcggatca 2356741 cattccagga aagcggcgtg aaatgagcag ttaagccgtt ttcgctgaca gacgatgatc 2356801 cgttggaatg cggaacgaca ttttttctgt tatgctggtt tgttgctttg atatcctgat 2356861 gctcaagtac gatgtgctct gcgatttggt aggattcaaa gcctctgagc gaaatctccg 2356921 tctccatctg atcctcagcc ttgtttaccg caaaaatagt gagtgtttct tcctcttcag 2356981 agtacacaac agcagcatca acatatggca catcagtgaa atcagaacaa tcgtacttag 2357041 gagaagaaat aagcggtttc agtgactcgc cccttccgta aacagaagca tgcatgtatg 2357101 gatagaaaat cggctgtctc catgcttctc cgcctttttc cgtcatgatc ggcgcgatga 2357161 cattaacaag ctgtgcaaga cacgcaattt tcacacggtc tgcgtgctgc agcatcgtaa 2357221 tgagcagaga gccgactaat aaggcatctt caaaattgta aatatcctct aaaatcggac 2357281 gcgcagtgat ccacggctcg acttttttat cagcctcatt tgagtggtac cagacgttcc 2357341 attcatccag agagagattg atagttttct tgctgcgtgt ttttgctttt acatagtcac 2357401 aggtcgcagc gactgatttg ataaaatgat ccaaatccat agaacgtgcc aagtagtttg 2357461 gcagattgtt atcccggttt ccgtagtaag tgtgaagaga gatatagtcg acatgctcat 2357521 acgtatgctc aagcaccttc gcttcccaat cgataaaggt cggcataccg ctgtttgagc 2357581 tgccgcaggc aacgagttca attgatgggt caacccactt catgaccttt gctgtctctg 2357641 cggcaagccg tccgtattca tcagctgttt tgtggccgat ctgccatggt ccatccattt 2357701 cgtttcctaa gcaccatgtt ttgatgccat acggctgttc atagccatgc gatcttctta 2357761 aatcactcca gtaagagcct ttcggatggt tgcaatattc aacgagatta cgggcggcat 2357821 ctatgcctct tgtgccaagg ttgacggcca tattgacctc agtgttcacc ttttttgccc 2357881 aagataaaaa ttcatttgtt cccacttcat tggtttctgt cgtttgccat gccaagtcaa 2357941 gccgtctcgg gcggttttcg actggtccga caccgtcctc ccagttgtat ccggataaaa 2358001 agtttccgcc cggatagcgg atgatgggaa cctgtaattc tttgatcagc gactggacat 2358061 cttttctaaa tccatcttca tccgcttcag ggtgatcagg ctcgtatatg ccttcatata 2358121 ccgcacgacc catatgttcg ataaacgagc cataaatccg tttatctact tcaccgattt 2358181 tatattcttt gtctacaatc attcgcgctt ttttcatcac acgtttcctc cttcattaac 2358241 ctttgactcc ccctaccgtc aggccggaga taaagtactt ttggaaaaac aagaaaatga 2358301 taatcaccgg caaaatcgca aatactgagc cggatataag catgtcgtaa ttatttccat 2358361 aagggctcag caagctggac agccctattg gaagcgtaaa catttctttc gaccgaagca 2358421 caatcagcgg ccacaagaag ttgttccagc tgtttaagga ctgaaggata atcatcgcac 2358481 cgaaagccgg tttcatcagc ggtgccataa tcctgaaaaa gatgccgaat tccgtacagc 2358541 cgtccatcct tgcagagtcc agcagatctc ttggaaggcc aagagcatat tgcctgaaaa 2358601 agaaaacagc aacaggtgaa acgataaacg gcaatatgac acccgtatat gaatcgatca 2358661 agtgcagtcc gacagtaagt ttaaacagag gaagcatcat cacttccagc ggaaccatca 2358721 taataatcag cacaagaaca aagatgatat ttctgccctt aaaatcataa accgcaagcc 2358781 cgtacccgat catcgaagaa aaaaacagag tgagcacagt cgtaaaaagt ccgagtacaa 2358841 gactgttaaa aaaccatttg aaataaatgc tgccgccatt aaacagaaat gtgtagttat 2358901 caaaactcat cacttttgga tcaatatcaa gattcagccc cacacgcaaa agctcagatg 2358961 acggctttaa tgatcctaaa agcaaacaga aaatcggaaa aagatacaat aggctcagca 2359021 tcataaaaaa cagggtcagc gcaattctat aaacgctaaa ctgaggactg tgccgcaaca 2359081 tttatccctc ccccttaaac gagcctgaca gctttaatga aatcaggctg acaacaagga 2359141 tcacaatcaa aagcacaatg ccgatggccg ctccgtatcc catttcattg taggcaagtc 2359201 cctgctgata caaatatccg acaagcgtca gaccaatatt acccggggaa ttattctgcc 2359261 aaaggacgta gctttcctca aacatcctga agccgccgat gatgctgatg gtcagcacat 2359321 atacggttac aggcttgaga aacggcagcg tgatgtgcag aaattttttc attgtattcg 2359381 cgccgtctat atcagcggct tcgtacagct ctttcggcac attttgcaaa cctgctaaaa 2359441 agtaaaggat gttgattccc atccatctcc atgaagcaag cagcaccatc aaaaacatgc 2359501 cggtatgttc attgttcatc cagttctgag gtgaaaagcc gagtttaagt aggatggaat 2359561 tggccagaga cgtttccatt tctccgaaga tcagccgaaa aatgatcccc gcgacaatgg 2359621 ttgaggtcaa tgccgggata aataatgctg atttaaatat atttctaaat ttgaccagct 2359681 ttgaattcag gaatatggcc agaagcaatg gaacaggaat cagcacgatc agcgtccaaa 2359741 aggtgtattc cagcgtattc caaagggcgg tatagaacgt cgggttgttt agcgctgtat 2359801 aattagacaa tccgacaaag gacacctctc ccggcaaaat tctttggaag ctcatgatga 2359861 agacactaat gatggggtat agaaaaaata cgagaaagga taaaacgaat ggcgctgtaa 2359921 acagataggg cgccgctttt tttgaataaa acagatctcg ccagcctgat tgtttcgcag 2359981 ctgaaggaac gggatgaacc gttcccgttt tcacaggttt catgagaacc tccccgcttt 2360041 cactttttga atgggattct atttctgttt cagttcacct gccgctctgt ccaaggcttg 2360101 tttaggcgtt ttttgctgag atttaagcgc gtcgaacaat acgcttctgt tgacaaggtc 2360161 tgaagccttg gcaaaatcct catgtaaata aattggattg atttcatcct tgatatcgag 2360221 cagcacagaa aaaatgcctg ttccgttttg gaagtaatcc gtgtatttgt ttttctcttt 2360281 caattccttg gagctccaaa catcccagcg aagcgggtca aagccgagta cgctccagag 2360341 ttttttattt ccttcttcag agcccttcgc aaaggccaaa aactcttttg ctaactcaac 2360401 atgcttggat tgcttcggta caacagttgc cgtaccgccc aaacctgccg agcggtcgcc 2360461 cccctctttc catgccggga gcggtctgat ggcaatcttc cctttcagat caggcatata 2360521 atcgataaat cttcccatat accaaatcgg catgagaact gaagcagctc ctccttggtt 2360581 cataaagccg tagtattctt cactgtgatg cccgccgccc ggcgcaggaa tcatcgtttt 2360641 atcattgatc atgtctttta aatattgaag tgtttttacg ttggtgtcat tattgaggat 2360701 cagcttgccg tttttatcaa aatagcctga gttttgctgt gaaatcatag ataagaacgt 2360761 tgcggaatca tttgtttcca ccgttcccat cggcttcccg gtcactttgc gcactttctg 2360821 tccggcttta tggtaatcat cccatgtttt aatatcgtca ggattgacgc cggctttttt 2360881 catcacatcc atgttataaa acatgaccgt tgtccctaca tgtgtatcga gtccgtaaag 2360941 ctttccgttt ttgctgtaca atgtcagccg cgcctcaacg aatttatcgc gatccttttc 2361001 aatcagcgga gtcaagtcgg caagcggtat gtcagagccc ttcaaaaagt ttgaaaaacg 2361061 ggccaattcg acatctgcaa tatcaggaac gccttctccc gctattaggg agatagataa 2361121 gttatcgtgc atttgtccat atggataaac gaccgtattc agcttaattt tgcggtcagg 2361181 atattttttg ttccattcct tcaccatttc cacatagaac tgctcatgaa gcccgttaaa 2361241 tgtccaaaag gtcagctcag tttcacccga tttgccggat gatttttctg ctgaacaccc 2361301 ggcaatgact aatgtcagca acatcatgag cacaagaaaa cagacagtca tttttttcat 2361361 ctgcgttacc ccttccattc gaggtgcggg ctattcatat agaccatggt tgatcagcgt 2361421 tttgttttca ttgatgattc ttaatccggt gcatcggtct cttaaggtgt gcgcgtgtct 2361481 gaaggcattt ttgacggaat cctgcccgac accgatttcg tcaaaatacg cagggcctcc 2361541 ggctgatctc agccaatcag ccagcacttc tcctctcggg agtgtttgat aagccgattg 2361601 gatggcttcc cggcggcttg gtgaaaattc gttcagcccg tcatcctgag cgagctttct 2361661 gtatgtgtca gttaataaaa cagcggcaca gcccaccttt gccccatgaa gaatctgagg 2361721 ccgttttttc tccattaact ccatttcaat ccaatgtgaa atatgatgct cgccgcctga 2361781 tgccggtcgg gaatgatcta atgccagcat gacaagcccc gatacaagta aagactccat 2361841 caaaacccgt atgccagttt ccgttttcat cgcaatgtct tctgtgtgtt caatgcaggc 2361901 agcaagcgcc tcctgaacga tcttagctcc tgcaggcgaa taaggctcac cggcaagatg 2361961 ccgggatatt tcccaatctg ctaaagacgt gattttaccg agcatgtcac caaagccagc 2362021 cgccaccatt gactgcggtg ccgcttttaa tagatccaga tcagcgaaca gcgcagatgg 2362081 ggccttcgtt tgaatggttg ttttcgtgcc gtataaaata atcggcgcac cggctgatgt 2362141 aaaaccgtct acagatggag cagtcggata agaaataaac ggcaaatctc tttgaaacgc 2362201 cgcaaagcgg acgatatcat gaatcgtgcc cgaaccgact gcgatcatga catccgttgg 2362261 ttgtttcgta tggatcagca catgaatgag cgatcgttca tcagctgtca catctccggc 2362321 ttcattttct ggaatgatca ggcactcggc ctgaaatcct tcttgattca gtcggttttc 2362381 taaatcaatt cctgcaatgc ggtgtgtatt cgcgtcgcag acaaggacaa tatgttgatt 2362441 gttttttcgt tttacataat ccaaaagcga atcagctgct tgcttaccga gaacaatttc 2362501 ttcaactttt ataggcaacg tcttttctcc ggcgttttca aaagcacgct gaacgtcagc 2362561 tgcgatacga ttcatatcag aatcccctcc tcagccaatt tggttacatc cttaatagaa 2362621 tccagcacat aatccggcgt gtacaaacgc tgttcaccct gtttcgcaga accagttagc 2362681 actaaggcgc ttttcatgcc ataaagcttc cccatcgcaa tgtcagattc aatgctgtct 2362741 cctataatca tgcattcatg tgcggacagc cccattgctg tacaggcagc ctccgccatc 2362801 agccatgacg gttttccgac aacaagttca gtcttcgctt gtgcagaagt ctcaattgcc 2362861 ccgatcattc cggccacatc aatggcattt ccgtcttcgt tcggaaaaga gcggtctttg 2362921 tttgtagcga taatacgagc gccgccggca gccgcttgaa aggcttgatt taaatcgtcg 2362981 tacgtgagcg tttcatgaag ggagatcacg agccaatccg cttccttcgg ttcgctcgcg 2363041 ttctgcacac cggccagcct cagctcgtca accaagcctt gctccccaag cacccatacc 2363101 tttgaaaaac gataatgttt tttcagaaaa gccgctgtca cgcttgatga cagaacaatg 2363161 tcgtttacgt ccgtttcaat ccccgcgcca agaagttttt ttctgcacat ggcacgggag 2363221 atattccccc ggttgcttaa aaagacgatt ttctttccca ttctcctaag cgttttgatc 2363281 gcttctcttg ctccttcgat caactcattt cctctgaata cagtaccgtc caagtcaatc 2363341 agaatgccag ccggtgacac aggcgtatca tgactggcca taatacgcat ttgctccgtg 2363401 ttttcgataa aaatgctttt catgcaggac tgtattgatt ggggttacat ccttgttcag 2363461 cataatggag tgataggcca tttcggcaac cgtttctaat acaactgcgt tatgaatggc 2363521 atttaaggcg tcagtgcccc agcagaacgg tccgtgatta ttcacgagca cacccggcac 2363581 ctgttcgtaa ttatgatgct gaaaggtttc cgctatgact tttcctgtat tcagttcgta 2363641 gtcatgaatg atttcttcat cgtacatttc tcgagtacat ggaatcgcac tgtcaaaata 2363701 atcagcatgg gtcgtgccta acggagggat gtctctgccc gattgcgccc agcttgtcgc 2363761 ccattgagaa tgggtatgga caattccccc gatattcgga aaggctttat atagataaac 2363821 atgggtaggt gtatctgaag aaggtttaag cgagccttcg acgacctctc catcaaggtt 2363881 caaaacaacc aagtcatcgg ctgtcaggtc gctgtattcg actccgctag gtttgatgac 2363941 aattctttct ttttcacggt caatgccgct gacatttccc cacgtaaagg ttaccagctg 2364001 atgctcttga agcttcaggt tggcagccag cacttctttt tttaatgttt caagcatgct 2364061 ccatcaccct ttatcaattc tttttggcgg cagatgaaaa ttgaagattt ttgatcgttt 2364121 tcagacgctt catgacatgg ttttcttttc cgaaataatg aaccagctct ttatattcag 2364181 cgtacaattt ttcataaacc gcggcgtttt cggcatttgg cgtataagtt atatctttca 2364241 gttttcccat gttcgccgct gcctttttga tatcatcgta gccgcctttt tctttgcctg 2364301 ctgcaagcgc gccgaaaatg gcagatccta aggctggggc ttgcggtgaa ccagagattt 2364361 taatgtccat gtttgtcaca tccgcataaa tctgcatgac aaacgggttt ttctcagcta 2364421 ttccgccggc tgcgaacagt tcctcaatcg gaacaccgct ttctttgaat gtttcgataa 2364481 tcatccgggt tccgtaagct gtcgcttcaa ctaacgctct ataaatctct tcaggcttcg 2364541 tcagcagtgt catgccaagc agcatccctg ttaaatctgc atcaacaaga gttgaacggt 2364601 ttccattcca ccaatctaaa gcaagcaagc cgctttcacc aggcgcttga tggtttgctt 2364661 tctcactcag cagctcatga acgccaatgt ttttttcctt tgcttcctct tgataagctg 2364721 gcgggacaca tgttttcaca aaccagtcaa aatgatcgcc gacacaggac tgcccggctt 2364781 catatcccgc atagcccggg agaattccgt tgtccacaac gccgcacatt cctggaacga 2364841 tatgcacctc ttcaccaagt agaacatggc acgtcgaggt tcccataatc atcagcattt 2364901 tccctggctc tgtaatgccg accgccggta ccgaaacatg agcgtccaca ttggcaaccg 2364961 caacagccgt tcccgggaga agccctgtca gctttgccat tttttcagtc agactgccgg 2365021 ctttttctcc tactgaatga atagaacctg acaatttgtc ctttgtaatc gttttcattg 2365081 aaggatttaa tttctcaaag aaatcatctg acggataccc cgctttttca ctccacatcg 2365141 ctttataccc tgcggtacaa ttgcttcgct tgagcgagcc gcacagctgg tacacgatcc 2365201 agtccgcagc ctcgatgatc cggtcagccg cttcataaat gtgaggcgct tcctcggcaa 2365261 tttgcatgac ctttggaatc atccattctg atgaaatttt tcctccgtac cgctgtaaaa 2365321 aagcctctcc ttcttcttcc gcgatttgat tgagccgatc agcatgtttt tgggccgcat 2365381 gatgcttcca gagcttcaca tagctgtgcg gctcctcttc atattcaggc agcatgcata 2365441 acggctgccc gctgctgtca ataggaagga tcgtacatgc cgtgaaatca attccaatcc 2365501 cgataatgtc tttcgggtca acgcccgtct gttcgagtaa agacggaatg gttgtttcca 2365561 agacttcgag gtaatcagca gggtgctgca gcgcccagtc acgcggcagc ttttgacccg 2365621 tttttggaag gacggtatca atgacagcat gcctgtattc ttttacagca gccgcaagtt 2365681 cctcccctgt ttggacatga acgagcactg ctcttcctga taaagttcca aaatcaaccc 2365741 ctattgtgta agccatgtga catccccctc tacttttgaa gccggtaaag cgcctcgttc 2365801 cattttaact cgtgtttcag tttatgaatt gtcgtatcac gggaaatgag aacactttcg 2365861 attcccgcca tttccgccca atcaagcatt tgctccgctg tcagttcata agacaggcag 2365921 gtatggtgtg caccgccggc taaaatccat gcctccgctg ctgttttcaa tgacggctcc 2365981 ggcttccaga gaacacgggc aaccggtaaa ttcggcatgt ctttttcaat ttcctggccg 2366041 ttgacttcat tcagcacaag gcggaaacgc ccgccaatat caacaatgct agcttgaatg 2366101 gcagaaccgc tgatgccgtt aaataccaaa cgcgcagggt cctctttgcc gccaatcgaa 2366161 agcgaatgaa cctcgatttt cggctgatcc aaagcgacag tcggacacac ttcaagcatg 2366221 tgagagccca gaatcatttc atttcccggt tcaaaatggt acgtgtaatc ttccatgaag 2366281 gaagttcttt ttcctttagc catgattttc atcatccgta caagggccgc tgtcttccaa 2366341 tctccttcac cggcaaaccc atagcctttc tccatcaggc gctgaacggc aagtcccggc 2366401 agctgtttca ttccgtgcag cacttcaaac gatgtcgtaa acgctgtgta tccgccttgc 2366461 tcaagaaaag cggttaatcc aagttcaatt ttcgcctgtt ctttaatgga cgctaccttt 2366521 gcttcgtcac gttttgtttc ctcactgatc acatatagtc tgtcatactc ggcataaagc 2366581 gtgtcaacct cgtcgtccgt aatgcgatcc atcacttcaa cgagatcccc gatgccatat 2366641 ccgtcaacct gccagccaaa ttgaatatgc gctcccacct tgtctccgtc cgttaccgcg 2366701 acatgacgca tgttatctcc aaatctggca accttaatat gtctgctttc atttaatgca 2366761 gccgccgtat ccatccactg ggacatttct tttttcactt cttcatcatc ccaatagccg 2366821 gcaatgactt ttcggctaag ccccattctc gagttgatgt aaccgtactc tcgatcgcca 2366881 tgcgcggatt ggttgctgtt cataaaatcc atgtcaatcg taccccacgg gatatcgcga 2366941 ttatattggg tatgcaaatg cataagcggt ttttgataag aggaaaggcc ttctatccac 2367001 atttttgcag gggaaaatgt gtgcatccat gtaatgatgc cagcacatgt ctcactgtac 2367061 tccgcttctc ttaacagctc tctaatggtt tccggtgaag tgacgacggg cttatgagtg 2367121 attttatatc tggaagaaat cccgctgagc ccctcacaaa tgcttttagc atgctgatct 2367181 acgagttcca gcgtctcttc cccgtatagg tgctggcttc ctgtcacaaa ccagaattca 2367241 taatcctttg tctgaagcat gtaaactgcc cctttctcat aaaataaaac gctttcaaat 2367301 acaaaagata cgtactaatg atagaaaata aacctataaa taaatatttg tacgaacaat 2367361 tttattatag taattgacta ttatactgtc aatcttttct tttaaaaaaa gccgggggca 2367421 gagcccggct ttttaattca ataggacggc cagcccgagc tccaattcaa atcattgatg 2367481 agaagctttg gaatgccgtt gtcattggca tcataggcat ggcgaacaag aatgtttccg 2367541 ttcacaatat cctggcctcc aggtcctttc cattggtcat tgcccgaatc caaaatggtg 2367601 cctccgcctt caagcatgct ttttccgctt ttatcaagat aagggcctgt aatgcttttg 2367661 gatcttccgt aagcaatttt gtacgtactg tttaccccgt cacagcattt atcaaatgaa 2367721 accattaaat agtaatatcc attttgatac gtaagagtag gagcttctaa ggcacctcca 2367781 ttattcggtc tagctgcaat cgaatagagc gagcctgtag gcttcattgt actcttatcg 2367841 agcttagtca gcttaatgcc gctccaaaac gagccgaatg caagccacgg gttgccatcc 2367901 ttatcgaatg tcagctccgg atcaatggcg ttataattat ttgagcttgt cgaacggatc 2367961 accaagccct cgtccttcca gccccccgaa ctgatgcttg ttgaagatgc caggccaatg 2368021 gcagatgtat tgcttccaaa agaagaaacg gaataatata gccagtactt gccgttatag 2368081 tattggatgt ccggcgccca ctggttttgg ccataattcg gcacataatt ggaccaccac 2368141 gatagcggtg tagtgaaaat ggatttttgt acggtccaat ttttagcgtc tgaagacttc 2368201 aaaacccgca gtccccgttc ttcagtaagc cctgttccga gcgcatacca tgagctcccc 2368261 tctttaatca tagtcgggtc atgaagcagc tcattggatg caccccaaaa cgctgcctct 2368321 gcgggagcag cagaagtgaa tatcaaacct gcagccagag ctgcactcga aaagtgtaag 2368381 aagcgtttcc atgttttttt ctttttcaat tttgttcaac ctcctttatt ttagaaagcg 2368441 cttacaaatt agattattta tcctcccttc ctgtcaaatc gactgcgtat cgtatatcgt 2368501 catgttcagg aaattttcgg tatccccttt attgtagtca ctatgctgta atttgtacag 2368561 acaaaaaaat agaatccacc tcaataggcg gattcttccg tatctttatt ggtacgtaat 2368621 ttcgtcaacc gtttttcggt ctaacttctt aatgacttct gtaattaact ttaccgcgtt 2368681 ttcataatca tcacgatgca gcatggccgc gtgcgtatga atgtagcggg ttgcaatggt 2368741 aatggacagc gcaggaacgc catttgccgt caaatggatg gcacccgaat cagttccgcc 2368801 gccggcaatg gcatcaaatt ggtacggaat gccggcttcc tccgcagtgg ctacaactgc 2368861 atcgcgcaaa cctttgtgag agaccatgga tgcatcgtaa acgataatct gcgggccttt 2368921 gcccattttg ctctgcgctt ccttctcgga aatgccaggc gtgtctcctg ctatccctac 2368981 atcaacacca aacgcaatat caggctgaat ggtgtgtgca gccgttttcg ctcccctcag 2369041 cccgacttcc tcctgcacgg ttccgacgcc atacactata tttggatgat ctgtgttttg 2369101 taagtttctt aacacatcaa tagcaatcgc acagccgatg cggttgtccc aggcctttgc 2369161 gagtaggaat ttttcattgt tcatgaccgt aaattcaaaa tgcggaacga tcatatctcc 2369221 cggaagtaca ccccactcca aggcttcttc ccggcttgaa gctccaatat caataaacat 2369281 gtcttttatt tccactgatt tttttcttgc ttcaggagac aaaatatgag gcggcttaga 2369341 tccgataacc cctgtgattt ctcctttttt tgtgacaatg gtgacgcgct gagcaagcat 2369401 aacctgagcc caccagccgc caacggtttg aaaacggata aagcctttat ctgtgatttg 2369461 tgtcaccata aagccgactt catccaaatg tccggcgatc ataattttcg ggccgttttc 2369521 tgcaccagtt ttttttgcaa ttaaactgcc caggcgatct gttgtcacct catcagcaaa 2369581 tggttctatg tatgatttca tcacttgcct tacttctctt tcattgcccg gtatgccttt 2369641 tgcatctgtt aaatctttca gcatggtcaa tgtttcatct aattttgcca tgttccaaac 2369701 cctccttcat cagtcctgca ttcttattat acaaaacatg gcgctaacca tacgactatt 2369761 tcacttgaaa atcgggtata tgtttttaca gctttctttt agaaaaagtg aaaccttttt 2369821 ctatgctttt cgtattacat cagatcatca ccataaggga ggtgccttca cacaatgttt 2369881 gtcatggttc taaggattat tttgcttgca ctttttgctt attgtattta tgccgtggtc 2369941 aaatatgtcg cgaatcctaa gagaaggctt aagctggccc aatcaaaaga acatttttat 2370001 attattgatg aacaaaacaa tacccggaag aattttcagc tgacgtataa aggcgtgctt 2370061 tttgagggag aaaagcatat tccttccaag gatcatccgc tgtttattca cacgatcttt 2370121 gtctggacag aatctcctga gaagctgaaa catttctctg caaaagattt tgagaacatt 2370181 gaagaaaaag tgctggaacg atatccaaat tgtaagattg actgggacca gcccattaaa 2370241 ctcgcaaaaa aagcagaaga gcgttaaacg cttttctgct ttttataaat caaacgggct 2370301 gtagtaaata gcgatgagaa tcgcttctat taccagaaga agcggtactc cgtacttaaa 2370361 agaagcgtgt ttcgttttat gtctgaaggt ttgcatgcca agccagacac cgagcgctcc 2370421 aaacacgatg gctatcagcc acagccggtc ttcagaaatt ctccacttgt gctgctgcgc 2370481 tttgcgtttg tcaatgccca tcacccaaaa accgcacaga ttaatcaaca ccaaataagc 2370541 agcaataatc atgttgcctc atcctttata tagaaaaagc cgctctgctg gagagcggct 2370601 ctatatgatt acttgtttaa ttgagcttta gcagcatcag caagctgatt gaatgcagta 2370661 agatcgttta cagcaagatc agcaagcatt ttacggttta cttcgatacc agaaagctta 2370721 agaccgtgca ttaaacggct gtaagaaagg ccgttcatgc gagcagctgc gttgatacga 2370781 gtgatccaaa gtttacggaa atcacgtttt ttctgacgac ggtcacggaa agcatagttt 2370841 ccagatttca tgacctgctg gttagctact ttgtataatg tatgttttga accgaaataa 2370901 ccttttgcta atttaagaac ctttttacga cgcttacgtg taacagttcc gccttttact 2370961 cttggcattg aatttccctc ctaattgttc cttatccgat tacttgatgt tagcaagcat 2371021 ttgtttgata cgtttgaagt ctcctgcgct tacaacagca ctcttgcgaa gcttacgctt 2371081 ttgcttttga gatttgttgg cgaataagtg acttgtgtac gcgtgagaac gttttaactt 2371141 cccagaacct gtctttttaa aacgtttagc agatccgcgg tgagttttca tttttggcat 2371201 gggatttcct ccttattgct tttcgttttt cggtgcgagc attaagaaca tgctgcggcc 2371261 gtccattttt ggttttgttt cgactgtcgc aacctcagca catgcttcgg agaaacggtc 2371321 taatacacgc tgaccgattt ctttatgagt gattgcgcgt cctttaaagc ggatagaagc 2371381 tttcacttta tcgccttttt caaggaattt aatcgcattg cgcaatttcg tgttaaagtc 2371441 atgctcatcg attgtcggac ttaaccgaac ttcttttaag ttaatgattt tttgattctt 2371501 gcgtgcttct ttttcctttt tctgctgctc aaatcggaac ttaccgtagt ccatgattcg 2371561 gcagacaggc ggttttgcat tcgctgcaac taacacaagg tcaagatttg cgcggccggc 2371621 gatttcaagt gcttcctgac gggacttgat tccaagctgg tcgccatttt gtccgattaa 2371681 acggacctca cgtgcacgga taccctcatt aaccaattga tctttgctaa taatgagcca 2371741 cctccatagt ttcttcgaat tgattcacaa ctcattttga atgcattttg caggcaaaca 2371801 aaaagtgtgg gcattataaa acacccacac tacgaacatc tgtatcaata aaaatgtacg 2371861 gtcaacctgc caactacatg catgtgtcaa tcaggtgaga agcgggtgct tctgcttgtg 2371921 atttatattc aattcaataa ctattctaca caataccgga tctttagtca aggacgactt 2371981 atccggaaca acttttacat tgtaacatgg gttttctatg agcgcaagag agaaaaagaa 2372041 aatctttcat ccccacccag aatacaaaga accaacaatt cccccttatt acgcaattta 2372101 caacaaaacc accgacagga agaaatgtaa aacaaagtta atctctgacc gatataagga 2372161 gcagaaggga gcctgacaca tgaacaaact gatacagctt gctttatttt tcacattgat 2372221 gttaaccggt tgctcgaata gcagcacatc ttccgaatca aaagtcgaaa ccactgttaa 2372281 gacaacggca gcatttcctc aaaaggagct ggagaaagag ctaaaaaaac taaaacccgt 2372341 ttcattggac atgaagttcg agagtccact cgctaccgag ttaggaaagc ggaaggcaaa 2372401 agaggaagct gaaaagcaaa gacaaatcgc cgctgagaaa aagcttgaaa aagagcggga 2372461 ggcgaaacga aagaaacagc aggaggaaaa agcggagaga cagcgattag cagagcagca 2372521 ggctgcagag agacagcgat tagccgaagc ggaaagacaa gctgaacttg aaagacagcg 2372581 gcaggcagca atccaaaaag agcagaaagc gaacgctgag aaaaagcggc aatcgcaggc 2372641 acaacggcag cagactgagg caccctcatc taatagtcaa gatccaccat cttcctcgag 2372701 tcagacagat aaaaccattc aacagccagc ttcagagctt cctgatgacg atggttatgg 2372761 ttatgaagaa cgaaaaaagt ggcatgacga tcaagtagaa tggggcatta aacaagggta 2372821 tatcgatccc gaagacgcac cataaaataa aaaaagccaa ggcattcagc cttggcttat 2372881 cctccgatca gctgcacgaa cacagggatg accagaaccg ttaccactcc tactacgaca 2372941 acagcaatac ttgccatcgc agcttcaact tctcccatct caatcccgac cgctacacca 2373001 agtgcatgtc cggatgttcc aagagccaat cctttagaaa tcggattttt cactttaaac 2373061 accttcaaga acaatgctcc gagcgcatat acgatgacag cgttaaagat gaccgcaaag 2373121 gctgtgatgt cgctgatgcc cccgatgcct tttgataaag gaagcgcaat tgccgttgta 2373181 gccgcctgcg gaagcatgct tttcattacg gccgaatcga gatgaatgcc tttagcgagc 2373241 agataaacaa tcgtgacaga gcagatagag ccggcaataa tggaggccat gatttgccac 2373301 cagtactttt taagcttatc tctttgtttg tacaaaggaa ttgcaaatgc gatcgttgcc 2373361 ggttcaagaa aaaacttaat gatctctccc ccgttattat aatccgcgta ggaaaaaccg 2373421 ccgattttta aaaatgcgat ccccagcacc atggcaacaa acaaaggagt gaaaaggaag 2373481 aagcctttcg ttttcttaaa taaaaaggtg ccgatgccga atgcagcaag tgatacgaca 2373541 atcccaaaat aaggactcat tgtgctttcc atgtgaagaa cctcctgttt cccttaatgg 2373601 tgaacgagtt cgttattgtt ctgcgggctt tgcactgttt ttgttttcat gtccgcttcg 2373661 gttttgcgtt ttccgctcag cgacagaatc agctgagaaa acaatcccgt agcccccagc 2373721 aaaataatcg ttgcgagcag aatgacaaga acaatttgca ggccgtattg ctgcatcaca 2373781 ccaagcgaat tcataacaga tatacctgat ggaacaaata aaaatccgat cagagaggtt 2373841 aaagacgttc cgagcgtctc cacttgttcc agtttaatga ctttcaaaca taataggaga 2373901 aataataaga ccaaccctac aaccgatgcc gggataggta ttgggacaat agcggcaatc 2373961 atatttgaaa ccagcataat gacggcaaaa ataaatgctt gtgttaaaaa cccgtacact 2374021 tttttagcac tcattttctt cacctctttc tctttggtac cctcattata aataagaatt 2374081 ccctgttata aagcgcttac aagataacat gccgtatagc gggtctgagt tgcagaatca 2374141 aatggctgaa atgcaaaaag ccgcccatca aatatggagc agctttttca attccttcgc 2374201 atatgtccgg ctgaccggta ttttcgatcc gtctttcatg atcagattat acgttgaatt 2374261 aaaccatggc tgaatttctt taatatattc agtattcacg acaaagctcc gatggacgcg 2374321 gataaaatca gaatccggca gctttttctc aatcacaacg agtgtatcgc tgaccgtata 2374381 agaatgatcg aaggttttta cattgacatg accatcttct gttccggcat agataatgtc 2374441 cttcgtatcc acaatcacaa tcgattcccc cacagatagc gcgagcttgt gctggccggc 2374501 atggctgttt tgctctgttt ctacaatatc ccgattgact tttttatatt ttttcagcgt 2374561 ttgctgaatt ctttcttcat cgaaaggctt ggttaaataa tcaagagcgt ccacctcaaa 2374621 cgctttgagc gcatactggt catacgctgt cgcaaacaca atagcaggag gatgcttcat 2374681 tttcttcaat cgctttgcga tatcaaaacc gttttctccg gataaatcaa cgtctaaaaa 2374741 cagcaaatca ggtttttgat ccatcatttg gtcaaaagcg gattcgatat tttccgcttc 2374801 attgatttcc atttcatcat tggtccgctt aagcaagtaa gccagttcat cccttgccag 2374861 catctcatca tcaactatta acaccctgag catgttcttc tccctctttc atctgttgca 2374921 ttggcacttg aaaggaaacc tctgtccctt tatgaacctc actgctgata tgcagtgcag 2374981 cctgctgtcc gaataaaccg atcagccgct gatttaggtt ataaagcgct gtaccggttc 2375041 cctccttaga cggaaacggt ttcttcccca gttccggcaa gacgtccggc ggaattccgc 2375101 gtccgttatc cgccaccttc atatagacgg atgcatcatc agataagaca cagactgtaa 2375161 ccttgcatat gtcttgtttt ttcggaaacg cgtgccgaag cgcgttctcg acaagcacct 2375221 gcaaaacaaa cggagggatt tcaatctgct ccagtctgct gtcgatatta agctcaattt 2375281 tatatttccc gggaaaacgc gcctgttcta atgacaaata ggcgttaaga tggttcagct 2375341 cctttgagag cggaatcagc agctgtctcg ctccttgaag gtttgaacga aaataaacac 2375401 tgagctgcaa taggagctta cgggtttttt caacatctgt acggcataac gcagaaatcg 2375461 tgttgatcgc attaaataaa aaatgcggat tcacctgtgc ttgaagcgct ttaatttcag 2375521 catccttgag aagtttgctt tgcagctctg cttccccaag ctcaagctgt gtcgaaaaca 2375581 gcatggccag cccctcggca agttcctcct ctacctgact caggcctgcc gggcttttaa 2375641 agtacatttt taaggtgccg attgtattgc cgttcgatgt cagcggtagg acaattgcag 2375701 cgtgcaaagg gcattcagca tgcgtgcatt caatctcttc ctgcgaaatc gccttcataa 2375761 tatgccctgt tttaatcacc tttttggaca ggccggtgat caagcttttc gatgggatgt 2375821 ggtgatccat tcccgcaccg acatgcgcaa ggatcttttc tttgtcagtg agagacaccg 2375881 catctgttcc tgtcagctta tggataatag ccgctacact tttacaggag ttttcattta 2375941 atccttggcg gaaaaatgga agtgtctgat cagcaatcgt aagcactcga tgcgtttcga 2376001 gagcccttgc ctgttcttcc ttgcgaatga tcgcttgaat aatagacaga aaaataaaac 2376061 tgcctgttcc attgatgagt atcatcggaa ttccgatcat gctgacaagc tcccaagcgt 2376121 cactgaacgg ctttgccatc agcaaaataa tgatcatttg cagtgactcc atgccgattc 2376181 ccacaagagc ggcgatgcgc ggtgtcggca ttcgatatcg cttcgtaaaa tacctgccga 2376241 tcaagcctgc aagaacaccc gctaaaatag atgagacggc acagcttaag gccgtgctgc 2376301 caccgagtga aaaacgatgc aggcccgcaa gtatgccgat cccagcccct acaaaaggac 2376361 ctccgagaag gcccccgatt tccacgccca aaatacgggt attcgcgata gagcccgatg 2376421 gatctatcgt aaacacccag tcattgttta caatcatatt tctttgaatt tcgatgcctg 2376481 tataattgct gatgatgctg aaaagagaaa aaatagaaat taaaatcgct tttcctttat 2376541 agccgtcctg attctgaaga gcttgtctga aaagtttcgt atgggcgaga atgaacccta 2376601 atataacaat aatccccact ctctccagca tcataatcat taaatgaatc attcatgtca 2376661 cctgttcttt ccgttttcat tctagcatgt tttcgttttg cggctgactg tttttttaaa 2376721 atcgtctgaa aacatatttc acaaggcttt tatctattgt aaaataaaac atgagccttt 2376781 tggcagaaag atttgaatct gaagcagagg agaagatcat gaaagccgta ttttttgatt 2376841 tagatgatac actactttgg gacgaaaaaa gcgtcagaac aacatttgca gaaacttgct 2376901 tacaggcgga gaaaaaatat ggccttgccc ctgaggaatt cgaagcagct gttcgcgaag 2376961 cggcgagaga attgtacatg tcatatgaga cgtatccata tacagtgatg atcggcatta 2377021 acccgtttga aggactgtgg tccaatttct cagagccaat cagtgaaggc tttcaaaagc 2377081 tgaacaagat tgtgccggag tacagaagaa atgcatggac caacggactg aaagcgcttg 2377141 ggatcgatga tcctgcatat ggcgaatact tgggagagtt ttttgcggca gagcgcagaa 2377201 agcgcccgtt tgtatatgat gaaacttttg ctgtactcga tcaattaaaa ggcaagtatg 2377261 aattattgct tttgacaaat ggcgatccta gtctgcaaaa ggagaagctt gccggcgtgc 2377321 ctgagctcgc tccttacttc aatgaaatcg tcatctcggg cgcattcggc aagggcaagc 2377381 cggatgtttc aatttttgaa cactgcctta agctgatgaa tattgaaaaa gacgatgcca 2377441 tcatggtcgg cgataatttg aatactgata ttttaggcgc ttcaagagcc ggaatcaaaa 2377501 ccgtttggat caaccggact gataagaaaa acgaaactga cgtaaagcct gattacatca 2377561 tcagcagcct tcatgatttg tttcctatat tagagaaata aaaaaagcat gatctcttca 2377621 atgagatcat gcttttttat tttatttttt cgcttcagct actgcctttt tcacaaactc 2377681 atcaagtgaa atggtttcag agttctgttc tccgtattta cgcacgttta ccgctccgtt 2377741 ttctgcttct tggtcaccga ccaccagcat gtacgggatt ttttgcattt gcgcttcacg 2377801 gattttgtag ccgatttttt catcgcggct gtcgacttca acacgcaggc cttcacattg 2377861 caggcgttcc tgcacttttt tcgcgtagtc taaatgcaca gccggagaaa ccgggatgac 2377921 ttggaactga accggtgcaa gccatgtcgg cagcgcgcct ttgtgttctt cgattaagaa 2377981 agcaacaaag cgttccattg ttgaaacgac acctctgtga atgacaaccg gacggtgctg 2378041 cttgccgtcc tcaccgatgt atgtcaggtc gaaacgttcc ggcaataaga aatcaagctg 2378101 aaccgtagac agtgtttctt cttttccgat cgcagttttc acctgaacat caagtttagg 2378161 tccgtagaat gccgcttcac cttctgcttc gtaatagtcg tggccgattt catccattgc 2378221 ctctttcagc atggattgcg ctttgttcca catttcatcg tcatcaaaat atttctctgt 2378281 atcttccgga tcgcggtaag acagacggaa tgtgtaatca cttaaaccga agtcttcata 2378341 aacatcctgg attaaacgga ctgtacggat aaactcatcc ttaatttgat ccgggcgcac 2378401 aaagatgtgt gcatcattta acgtcattcc gcgtacccgt tgaagtcctg acagcgcacc 2378461 tgacatttca tagcggtgca tcgttccaag ctctgcaata cgaatcggaa gctcgcggta 2378521 actgtgaatg tcttgtttgt aaatcatcat atggtgcgga cagttcatcg gacgcaatac 2378581 aagtgtttca ttgtccattt ccatcggagg gaacatgcct tcctgataat gatcccagtg 2378641 tcctgatgtt tcatacagct ctttgctgcc tagcacaggt gtgtatacgt gctcatagcc 2378701 gaggctgatt tctttatcga caatgtagcg ctcgatgacg cggcggattg ttgcgccttt 2378761 tggcagccaa agcggcaggc cttgtccgac tttttgagag ttcgcgaaca gctttaattc 2378821 tttgccaagc tttctgtggt cgcgttcttt cgcttcttct agcatacgaa gatgctcttc 2378881 aagatcagct tttttgaaga aagctgtacc atatacgcgc tgaagcattt ggtttttgct 2378941 gtcaccgcgc cagtatgcgc ctgcaaggct taacagctta aattctttga tttttccggt 2379001 tgaaggaaca tggacgccgc ggcacaggtc aaagaattcg ccttgctcat agatcgaaac 2379061 ggtttctcct tcaggaatcg catccaatag ttcaagcttc aggtcgtcgc cgatttccgc 2379121 aaaacgggct ttcgcttctt cacggctgac ttcttttcga acgatcggaa ggttcgcatt 2379181 aacgattttt ttcatttctt tctcgatttt cggcagatcc tccggtgtaa tcgcttcgtc 2379241 catttctaca tcgtagtaaa aaccgttttc gataaccgga ccgacgccga atttaacatc 2379301 cttgtagatg cgtttaatcg cttgagccag caagtgagcc gcactgtggc gcataatttg 2379361 aagaccttct tctgagcctt ctgtaatgat ttccactgta ccgtcttcat tgatcggcgt 2379421 tctcaaatcg atttcttttc cgttcagttt tccggctaat gactttttct ttaatcccgg 2379481 actgatggat gccgcgatat cttctgttgt tgttcctttc gcaaactcct tgactgctcc 2379541 atcaggaaat gtgattttta ccatatctga catctttgtc actccttttt ttgcatataa 2379601 aaaccccgcc ccctatgaaa gggacgaggt tgaataaacg gaatcgtggt tccacccttt 2379661 tttccgcaaa gccaatacac ggcacctgcg gctctaagct ctgtaacggg agttcccgtc 2379721 agccattact gttccttttc aagaggttca cagctgaagt tcaaaggcgg taaagcgaat 2379781 ggtccttagc tgggaagctt gcagccaggg cttccctctc tttgagccgg tatcattcct 2379841 tcgtgtcctt atcaatacgt gtgtctttct taatctccta tgtattataa attgttcaat 2379901 ccaaaaaatc aacacgatcg cgtttccttt tttttaaacc gacagcctta aatagacagg 2379961 ctgccggccc tcatccttcc gagtgcttca ccggtatttc tgcatctgta aaagcatgca 2380021 gcgggagcat ttccactctc tcttgaaata cgttttgaat ggtccttgcc atcatgtgct 2380081 cgggctggtc ggtataaagc acgacttcat caggcgcaat ggaaatcagc ggcgcgagca 2380141 aatgagaatc aatatacata ggatgatccc ggacaaatct tctgtctatg tatttcattt 2380201 tttcccgttc cggcacatag cgcagctccc ataatgtaaa ggaaccatca tggacaatat 2380261 gcactttttt gattcgcggc tgtttggcgt ccacatagtc tctgagtgtt tgaataaagt 2380321 tttgatattc ctgttccatc ttatattcat caatcgctgc ttctgtaata tctctcagct 2380381 gcttatagta tgatccaagt cggaaggtct gaaaggagcg aatgtaaaat actccttcct 2380441 ctaaacagat cgtttggagt tcatccaaaa ttgattgttt ccgtgaaagc ttcagcggct 2380501 caaacggaag atcgtctgct tcaccttcaa taatactgtg tgcgagctga aggatttgct 2380561 gctgttcatc ctggtccgtg aaacaatacg tttcctcaat caatgacagc atatgctcgt 2380621 cttctttgca ttccaaaaaa aatttgacca gaatcggctc cataaaacgc tgaataggaa 2380681 aagccggatt cgctttttca atcccgattt ttcgtatgcc ttcacggaca atgatattgt 2380741 tccgatcgtc cgaatgctga atgagatgta aaaaagcggc tgcatcatgg tcatcttcaa 2380801 agattatttc aagcatgttt gtcccccctt acggcatctg ttacaagtat atgggggatg 2380861 tttttaaaat agacgtaaag gtcattggca aatcttaatt tgattcttgg aacaagtttt 2380921 gcattttctt tctgaagatg aacggcaatg agataaacac gatatacaaa gcgagcacca 2380981 taaagaaagc gggcagattg ccagccaaaa agctcgcacc cagcacatta agcgcaatcg 2381041 tcccagggat gattcccaca gccgttgcgg caaaatacgg cagcgctttg acattggaaa 2381101 ggcctgccgc atagctgacg aaatcaaaat tgatcggcag gattctcaaa agaaagatat 2381161 agaaaaatcc gttatcctcc atttgcttct gtatggcttc aagcctttcg taatgcccgt 2381221 tctttttcgc cgaaaacaaa ccagccgcaa aaaacgaaac agctgaagcg cacatcgaac 2381281 cgaataacgt ataaagcgtg ccgagaagcg ggccaaacgc aagtccgcca gctattgaaa 2381341 taacagacac cggaaataaa acaagtggcc tgacgatgga tatcccgata aacatcagag 2381401 gtgcaaagac tccgaacgac aatacccata ccctgatttc tttcggcgat acattcaaat 2381461 acgttttatt tccccaatag agtaaaccag cacctgcaag cactgccagc catttgacag 2381521 ccgtttttcg tttcataccc tcagttcctt cccctttgaa ccacagcaat tatggatgtc 2381581 ggcggttttc tccgtcaagg cggatcggag cagccaaata taatatccgc tccattaatc 2381641 ttgcagcttt tacttcttct ttttctcccc tctgcgaata cgtaaaatga tgcttcagct 2381701 cgtcaggtga gaaattagaa gaaaagaacg ttggcagctg ctgggacatt ctgtgctgaa 2381761 gcaccgttcc gatgacctca tcccttaccc agcttgtcat tgattctgct ccgatgtcat 2381821 caagcattaa tacgggtgtg gtctttacca tattgagctt ctcttccaat gtctggtctt 2381881 gcagcgaatt cttaagctct ctcacaaatt caggcacata aacaatcatg gaggaatact 2381941 ctttttccgc cagctcattg gcaattgcag cgagcataaa cgtttttcct accccaaatt 2382001 tcccgtataa atataatcct ttcccttttc ccgtctcatt atagcttttc aggaagtctg 2382061 taacatgctg aaacatcgcg agtctgcttg ggtcactgat atcaacttgc tggaacgtcg 2382121 ctccaagaag atcctgctgg atatacatgc ttttcataag agactgttgt ttcttctgct 2382181 ggtcgagctt ccgtttgact ggacattcgt aatactcgat atcaatagac ctcccattga 2382241 caacaagctt cggatggtag ccctccaaca aattgttgca gttttcatct tccgaacaat 2382301 aggagcaatt cttgctttgt tcgatatatt cataaagctt atttaagctc ttttcgatca 2382361 ttttttggtc aatcacttct tcgttttcct tcaaaaatgc ttgaacatct tgatctttca 2382421 tgactttttc cttcatttgt tcaagacgtt tttggaaatc cggcctgccg gttacgccct 2382481 gcagggaacg gccgattggt tccatctatt ccttcacccc gcatctctgt ctttaatagg 2382541 cagagtattt tttcagtttt tgcatttctt ccatcatctt tttcttctgt tcttccaaat 2382601 cctgcggatg cagcttctgc tgtccggatt ctgaatcgga cgctgtttcc ttttctgtca 2382661 tccaatcagg aagcttttct tcacgaatca ctttttggtt tcgtttcgaa gactttgttt 2382721 ttccctcagc ccattcaaga tactggcggt tttcttctat tgcgagcttc atcgcttccc 2382781 tgaccgtttt cacctttttg cgtgcccaat gcgaagcgat tttttggata tagtttttcg 2382841 acagcttcat gtcggttttc agcatgacat aataaattaa cacatttgtg acgcctggct 2382901 cgagcttctg ttcgaacata atttcttcta tgatcttcag atcagctttt gacggctctg 2382961 ttccgtcagc aatgtcctgc agaagcttct tcggggaaat cgcctccagc aatgcaatca 2383021 gcttcccatc cagagaatcc tcttctgccg gttgttcgcc ttcacgcaga tgcaccggct 2383081 gtgttttttc caccaaatcg ggcagctgtc cgtttctttc aatttgatac cagtcgctcg 2383141 ccgcttttct taatgcctcc gtcgtaatga cgtcacgctc atcaattgcg ctcatcacaa 2383201 cattttgcat ttgcaaaggg tcaattccgt acagataaga aagctttttg attgtgtccc 2383261 gcacctgctg ggtcatcgct tttctcggta tcatcgtctc agaaagtccc gctaaaaaca 2383321 aatcaaaatc aaacacatcc tccgttatgg tgtaggacgg agactgtccg acagaagtat 2383381 actcggaccc ctcggcaagc cttaccgttt cctccatatc ggatgtgagc ttccattcac 2383441 tcggctgcag cgattcaaac gcatgattaa acggacgcgt aatgtccttc gcatcttctg 2383501 aaatggccgg gtgcgtaaaa aattgtttta attgctgata tttcgttttt ccgaccctat 2383561 tatacagaaa aacattcagc attccgtctt caaaaaattc atttggtctg agcggcggaa 2383621 ggagttcata tataaagagg cgctcctgcc gctcggattc tttcatatat actttcagca 2383681 atccgatgcc ctcgagcttc ccctgttcct gatggatcgt ttttaagttg gactgtgtca 2383741 tccccatcag ctgtctatgt gtggactctc cgccccacag acggttttgt tcaagctctc 2383801 cccacaatgt catataaaga gagaatgcaa cagggccgat taagggctgg tacagttgtg 2383861 taataatttg tctgtcaata tcctgcagca tcgatctgct tttaaccaca tacgggtcta 2383921 caggcagtac atctttccaa tagtcagcca tacattctca aaccttccga atttgtttct 2383981 acctttcatt ttacaccgtt tcttatatct atcaaatgcc aattttgcac atgagaaaag 2384041 agctagaaga atcctcttag ctcttttaac gctctttctt tattaagtct tttaattcat 2384101 cgataaagac gtttatatct ttaaactgcc gatagacgga cgcgaaccgc acatatgcga 2384161 cttcgtcaat cttagccagc cggtccatga ccatttctcc gacgagctca ctcttcacct 2384221 cggagcagcc ttgattgcga agttcttttt caatatcaaa gcacatgtct tcaagcgttt 2384281 tgagtgaaac aggccttttt tcacatgctt ttatgaggcc gcgcagcatt ttttctctgc 2384341 tgaattcctc acgcacacct tcttttttca caacgatgag cggggtttcc tccactttct 2384401 caaaggtcgt aaaccggtag tggcaggatt cgcactcgcg tcttcggcga atcgactttc 2384461 cgtcatccac aggccgtgaa tcaaggactc gtgttccgtt atgctggcat gaaggacatt 2384521 tcaataaaat cagctcccaa ctatatcgtt ccctgcaatg tattttcggc agcctccgcc 2384581 ttttaaaaat agatgtgaca gcatctgtcg ggagagccgt tgttaaattt gtttctatag 2384641 cattaggtgg tttgtgaaaa tctccttctt attttacaaa aaaaatgaaa aaagaaaaag 2384701 ctgacactct cgtttcttta taaaaataaa aggagcataa gctaaaaagc gcataatggc 2384761 tttctagctt cagctccctt tgtgttcgca atttacttta tagtactttc gcttgcgcct 2384821 gtttaatttg cacaggcccc attcctcttg gtatttcaat gttttctctt gtatcagcat 2384881 gtaatgcctc tgcaatgtaa tcagcagcga cattaggatc taagtctcca caagtataaa 2384941 catcaatgct cgcatatccg tgctcaggaa aactgtgaat cgttaagtgt gattcagaaa 2385001 taatcacaac tccgcttacg ccttgcggtg caaatttgtg aaatgcaacc tcgcgcacct 2385061 cagcacctga ttttagagca gcatttacaa acgttttttc aataaaatcc atgtcattca 2385121 gcttatcaaa atcgcatccc catagctcgg agataacgtg acgccccatt gtttccatag 2385181 tcatggaccc cccttaacaa gaattaaaaa gtgaaattcc aacaactggg tcggccattt 2385241 accacggggg aaagttagtc cggagaggtc ctaacccttt aagtaattcc gaaacagtct 2385301 caagcaagaa gttcacgaaa aatagtatac tgtgtttaag tctaatttgc aaggtgcgtt 2385361 ttttcagaaa tatgctgtta agggtttttt ctttaaaatg tgtccatgac cttattttat 2385421 acagcagacg gatgtttcat tcgtgccgct acatggcgga ttagatcaac aactctgcag 2385481 gagtagcccc attcgttgtc ataccacgcc agcaccttta ctttcctgtc ttccattacc 2385541 attgttgtaa gcccgtcaat gaccgctgaa tgcggattcg tattataatc agtcgaaacg 2385601 agcggttcat ctgagtaatc aagtacaccg tacatcgacg ttttggcagc gcgtttaaat 2385661 gcctcgttta cttcttcagc cgtaacatcc gttttcagat caacaacgag atcaaccaat 2385721 gagacgttcg gaacagggac acgcaaggcg aggccgtgaa gttttccttt cagatgcggc 2385781 agcacaagcg aaagcgcctt tgccgctcct gttgttgttg gaatgatgga ttcaccgcaa 2385841 gcccgcgccc ggcgcaaatc tttgtgcggg ttatcaatat ttttttggtc attcgtatac 2385901 gcatgaactg tagtcatcag accgctctca atgccaaact cttcatccag cacttttaca 2385961 acaggcgcaa ggcaatttgt cgtgcatgac gcatttgaaa taatgacatg gcgctcagcg 2386021 tcgaattggt cctcatttac gcccatcaca atggtaacgt cttcattttt tcccggagcg 2386081 gtcaaaatca ctttttttgc acctgcttct atatggccca tcgctttatc tttagcatta 2386141 aacttccctg ttgcttcgac gactatgtca atatcatatt cccgccaagg cagctgtttt 2386201 ggatcacggc tgtttaacaa aagcactttc tttccattta cgatcaggct atcttcacca 2386261 gccacaacct ctttgtcgta tctgccgtga attgtgtcat actttattaa atgagccagc 2386321 gtttctgcgg aatagctggc gttaatggcc actacttgaa tttgatcgtc taacatcgct 2386381 tttctaaaaa ccattcttcc gattcttcca aacccgttga tcgctacttt taccttcatg 2386441 ttggacaccc cttatcaatt atgccatcct aatttgttac tatctaaaat tagtataaca 2386501 cattaaaaca aattcgccag tacatattga taaaaatcaa cgattataac gctaatttat 2386561 gatgcatctt atgttttctt gcacagaata tcaggcgtaa gaaccaaaaa gcagccagcg 2386621 ctccgcactg actgccctca tgctttatga ttcctgtttt aacttatcat tgagcacact 2386681 ttcttctagc acagaaaatg tatccccgta cactctgtta atatgattcg ctccccaagc 2386741 acacagcata tctaaaatcc cttctaagct gcggccgtat tcgctgagct cgtattccac 2386801 tttgggagga acttgattat atacgattcg gttaatgaca ccgtccgctt ccagctcgcg 2386861 cagctgctga gtcagcattt tttgcgtgat attgggcatt aggcgtttta attcacttgt 2386921 gcgttttttt ccgtgcgtca gatggcataa aatgacgcat ttccatttcc caccgatcac 2386981 ttcaagagtc gcttcaacag aaatgttata ttttttcttc tccatacaat ccattctcct 2387041 cacaggcacc aaaaagtgac tatagcactt caaagtacgt acttttattt cttaacgata 2387101 tgtttcataa tcacatttgc cggctgattt gaatctgctc ttttttattt atatagctta 2387161 ctcggcagaa tttcaatcat acaacacatc ttacaaagga ggaacatcat gacttcagcc 2387221 aataaaagca atattcctgc actactggct ttggccgtaa gtgcattcgc aatagggaca 2387281 actgaattta tcagtgtcgg ccttttgccg ctcattgctg atgacctgga tattcccgtc 2387341 acgacagcag gattgaccgt ttccctttat gcgctcggcg ttacatttgg ggcacctata 2387401 ttaacttcat tgacctcaag catgtcacgt aagacactat tgctttggat catgtttatt 2387461 tttattgccg gtaatacgat ggcagcaacc gcttcaagca tcgggatttt actagcagca 2387521 cgtgtgatat cggcattttc gcacggtgtg tttatgtcga tcggttcgac aatcgcagcg 2387581 gatattgtcc cggaggataa aagggctagc gcgatttcaa ttatgtttac tggcctcact 2387641 gtggcaactg taaccggagt tccttttggg acatttatcg gccagcagtt cggctggcgt 2387701 ttcgccttta tggtcattat cgccgtcgga atcattgctt tcattacaaa tggcattctt 2387761 gtaccgtcca aattacgaaa agggacgaaa acaacgatgc gggatcaatt gaagcttgtg 2387821 acaaacagcc ggttattgct tttatttgtc attacagcgc ttggatacgg aggaacattc 2387881 gttgtgttca cgtatctgtc tcccctgctt caggaagtaa caggcttcaa agccgggact 2387941 gttgcagtga ttctgctcgg atacggaata gctattgcta tcggcaatat gattggcgga 2388001 aagctgtcaa accgaaatcc gattgccgct ttattctata tgtttatcgt acaggcaatc 2388061 gttctattcg tactgacatt tacagccccg tatcaagcag cagggctcat taccattctc 2388121 tgtatgggat tgctggcctt tatgaacgtg cccggccttc aggtgtatgt cgtcatgctg 2388181 gctgagcgtt ttgtcccgag tgcagttgac gtcgcatccg cgatgaatat cgctgccttt 2388241 aatgcaggga tcgcgcttgg gtcatacctt ggcggtgtga tcaccgattc aatcggattg 2388301 attcataccg cttggatagg cggattaatg gtggtcggtg cagtcatttt aacaggctgg 2388361 agccgcttga tggaaaaacg agatcggcag gaagcctgac aattttaaag gaggaaataa 2388421 acatgacaac acatttacaa gcaaaagcaa cacttcataa tggggtagaa atgccttggt 2388481 tcggcctcgg cgtgttccaa gtggaagaag gatctgaact ggtaaacgca gttaaaactg 2388541 ccattgttca cgggtaccgc agtattgata ctgcagcaat ctatggaaat gaagctggag 2388601 tcggagaagg gattcgggaa ggcattgaag aagcaggcat ttcaagagag gatctgttta 2388661 tcacatcgaa agtatggaat gcggatttag gctacgaaga aacactcgcc gcgtttgaaa 2388721 caagtctgtc caaactcggt ctggattatt tggatctata cctcatccac tggcctgtag 2388781 aaggaaagta taaagaagct tggagagcgc ttgaaacgct gtataaagaa ggccgtatca 2388841 aagcgattgg cgtaagcaac ttccaaattc accatcttga agatctgatg acggcagctg 2388901 aaattaagcc tatgattaac caagtggaat ttcacccgcg cctcacacaa aaagagttga 2388961 taagatactg ccaaaatcag ggcatccaga tggaggcttg gtcaccttta atgcagggac 2389021 agctgctgga tcaccctgta ttggctgaca tcgctcaaac atataataaa tctgtcgcac 2389081 aaattatttt gcgctgggat ctgcagcatg gcattataac gattcctaaa tcaacgaagg 2389141 aacaccgcat taaagaaaat gcaagcgtat ttgactttga attaacgcag gatgacatga 2389201 accgaatcga tgcactgaat gaaaacttgc gcgtcggtcc tgatccggac aactttgatt 2389261 tttaatggcc aaaaaacacc gttcaatatg aacggtgttt tttgtattat gcccagctgt 2389321 tcatgatttc atcaagctgc cttttggtct cttcaagcgt gccgctgtta tcaatgactt 2389381 gatctgctct tgctgttttt tcctctaagg gcatttgaga gcggatacgg ctgactgctt 2389441 cttcttctgt cagctgattg cgcttcatca gacgttccag ttgaagctct tttgtcacac 2389501 tgaccacaat aattttatca accaatgatt ccaatttgct ttcgaacaat agcgggatat 2389561 ccaatacaac aaatgcctcc cgatttgcaa cggcttcatc acggcgattg agcatttcct 2389621 gcctgactgc gggatgaaca attgcattta aagcgagacg tttttgttca tttgtaaata 2389681 ccagcgctcc aagctttttt ctatctatat cgccatttga gagcagtatg tcttcaccga 2389741 attcgtcaat gatttgccgg taggccggca tccctttttc taccgcttgt tttgcaatga 2389801 tatctgcatc tataactgtt attccttttt caatcagcat attggctacc gtgcttttgc 2389861 cgctagctat tcctcccgtt aaaccaatga ctaaggtcaa gagatccact cctttttaca 2389921 atttccagag cccaatcgtg attaatagaa gccccggcaa aaacgccatt ttatcgatcc 2389981 atttccactt agacagaaaa tggccggcat tgattccaat tgatacaaac agcgagctca 2390041 tgattgccac ggcgatgctc atcacaatcg gcgaaaaacc gagaatggct gcgcctatac 2390101 ctgctccaaa ggcatcaatc gataaggcaa atcccaataa gaccgcctca attccgttga 2390161 tcacacccga tttgtcgata tccgcactca tgggttttct caaaatatga atcacaattc 2390221 ctaatgaccg aacctctaga ttaagcagtg ttttttcatg caataggtat tctttatctt 2390281 ttgccggttt gaaaaattga tacagaaccc acgcaccgat tccaaccaat atcaaaccgc 2390341 caagcttctc cgtcacatat acaggaaaaa acttcgtgag aaagcttccg atcagcatgg 2390401 atataaacat gacagcaccg gaacagcagg cgataaccaa aatcgcttta aacggtattt 2390461 tcatttttct caatccgtac gtaaatccga ctgaaaaact gtccaagctg acagccaacg 2390521 ccagcagcag tatagaaacc atttgcatat ccgtttcttc ctttctgttg gtgctcttgt 2390581 atcagatgtg aaatgcccgg gattcatcac aatcatatat atgggaaagt gaaaaatccg 2390641 tgtttcgaaa atggcatcct taatccagag ttactgatat atgcaccgac agcttggaca 2390701 atgaagcatt atgctacttt tttgtctggc actttgcgca aaaatgcgtg cctcttcctc 2390761 caacgacaat tttcgaaatc atcgttccgc aatttttgca tggctcgtct ttttttccgt 2390821 acacaaaatg ctgcagctgg aacattccga tttccccttg ggagttgata tatgaacgga 2390881 ctgtgcttcc gcccgcatca atcgcctcct gcagagtgtt tttgatttca gcgtgaaggg 2390941 ttttgattgt tttatctgat aattgatttg cttttgtctc gggatggaca cccgctctga 2391001 aaagagcctc atccacataa atgttcccga gtccaactac cgttttttga tccagtaggg 2391061 cagttttgac agcgcggttt gttttcgcaa gccggtcttt taaatacgca cttgtaaatt 2391121 cttctgcatc cggctccggc cctaactgag aaagcgggag ctcgcccgct tcttctcccg 2391181 gtttaaataa gtgcatggtt ccaaatttcc gcacatccct gtaccggagc tgggttccat 2391241 ccgtcatcgt gaatatgaca tgcacgtgtt tatcgtcagg ctcctcggct tgatgaagac 2391301 cgtattttcc ttccattcga aggtgagaaa ccataacata atgatctaaa tgaaacagta 2391361 aaaactttcc ccgtcttccg atggactgta tcgtttctcc tgctagtttt cgcgcaaatt 2391421 cctccggttc ggcaggccgt ttgatgatat tcggccatct gatctctacc gatttgattg 2391481 tttttccctt tacaagcccg gtcagagtgc gccggaccgt ctcaacctct ggtaattccg 2391541 gcacatccat cacttcctat ctctgtttat ttcgcatcgt accaagatgg gcctgatgca 2391601 aagtccacct ttaacggcac atctaatgca agcgcatgct ccatcacttc aggaacaagc 2391661 ttttcaagaa tttcaatttc ttcctttggc gcctcaaaaa tcaattcatc gtgtacttga 2391721 agcagaagcc ttgctttcaa ctgtttttct ttcagcttgg cagccatgtc aatcatggct 2391781 tttttgataa tatcagcggc gcttccttga atcggcgtat tcatggccgt ccgctccgca 2391841 aaacttcgga tattaaagtt ccggctcgtc agctcaggga tgtagcggcg gcgatgcata 2391901 agcgttgtta cgtatccttt ttgtttcgct tcctgtactg aatcttccat gtacgctttt 2391961 acgccttgga agctttccag atagcggtcg ataaatgctc ccgcttcctt ccgggtaatg 2392021 ccgaggttct gtgacagacc gtaatcgctg atcccgtaaa caatgccaaa gttgaccgct 2392081 ttcgcctggc gtctcatcgc agatgtcact tcatccttag cgacatggaa cacatccatt 2392141 gccgttttcg tgtgaatatc catatcatta gtaaaagctt cgatcagatt ttcatccttt 2392201 gaaatatggg caagcacccg cagctcgatt tgtgaataat cggctgcaaa aatgagccag 2392261 tctttttcag acggcacaaa agcttggcga attttccgcc cttcctcaag cctgatcgga 2392321 atgttttgca ggttcggatc agtcgagctg agacggccag tttgcgttaa ggcctggtta 2392381 aatcgcgtgt gcactttatg cgaatccggt ctcgtcacct ttaaaagccc ttcgatatat 2392441 gttgattgaa gcttgccaat ttgtctgtac tgtaaaatat agtcgacaat atcatgcttg 2392501 tcagccagct tttcaagcac atcggcagac gtagaatagc ctgttttcgt tttctttacg 2392561 acaggaaggc cgatcttttc aaataagatg acgcctagct gtttcggaga attgatgtta 2392621 aacggctctc ccgcaatctc atggattttt tcttcatatt ccttcagctt cgcacccagt 2392681 tcttcaccca tccgttttaa acggtcaaca tcgaccttga cgccagttga ttccatttcg 2392741 ccaagaataa gcgcaagagg catttccagc tcttcaaaca gttcaagctg gtcgttgttt 2392801 tccagctctt gaacgagctt ttcccgaagg ctttgaatcg ctaacgcttt tcggccaagg 2392861 tgctcagaca gtacgtcttc tgacggcact gcccgttttg ctccttttcc ataaactgat 2392921 tcatcacttg aaacgatatg caggccgtaa tccttagcca cactcgcaac gtcgtcatat 2392981 gaattgcccg ggttgatgat ataagccgca aggagcgtat caaactcggc tcctttcagc 2393041 tcaatgccct gccagcgcaa agcgacaacg gcccgcttgc tgtcgaagac ccatttcttc 2393101 tgctcgtcat tttccaccca ttctttaaac acctcagact caacggcaat gtctttcgga 2393161 atgaaataag ctcccgtttc atttacgatc gaaaatccga ggatcggctc ttcatgataa 2393221 ttatcgccaa tctgttcaac gacaaatgcg gatggagaaa ccaatatatc gcttgtcacg 2393281 tctgtgactg ttttgacatt aatgtcttcc aacgattgat cctgttctgc ttctgcactg 2393341 tcttctccaa gccgttcaag aagcgtgttg aagccaagat ctttaaagat ggcaatgacc 2393401 tgttcacgat taaagccttg atattccagg ccggaaacag atacctcaat cggagcatcc 2393461 gtcataattg tcgcaagctc cttgctcatc aatgcctgat ccttaaactc ctcaagcttt 2393521 tccttcaatt tctttccgct cacctcgtca atggactcca gcagcttttc aacggaatca 2393581 aattgtttta aaagcttaat cgcagtcttt tctccgacgc cgggcacacc cggaatatta 2393641 tctgaggaat cgcccatcag acccttcatg tcaatgattt gttcaggcgt aagcccatat 2393701 ttctctttga catgctccgg tgtgtaaaat tcaacatcgg taattccctt tctcgtaatg 2393761 gcaactgtcg ttttgtccgt tgccagctgg gttaaatcct tatctcctga gaaaacctta 2393821 acttcaaatc cgtctttttc agccgatttg gccagtgtgc cgataatatc atccgcttca 2393881 tattgttcca gttcatagcg gctgatctgg taggcatcca gcagctcgcg gataaacggc 2393941 atttgttcgg aaagctcagg cggggttttc tgtctgccgc ctttatattc tttaaatgtg 2394001 ccgtgacgaa atgttgtttt cccggcatca aacgcaacca gcatgtgcgt cggtttttca 2394061 tcctcaagca ttttcatcaa aatcatcgca aagccgtata cagcattcgt atgaacacct 2394121 ttatcattgc ttaacagcgg caatgcaaaa aacgcccggt aagccagact gtttccgtct 2394181 acaagcacta atttttttcg ttccgtcatt caatttcctc ctaagaagcc tcaggcttcc 2394241 attcatctct tacatagtca ttagctcctc ttattttaac aaagttcaat ttgaaaggaa 2394301 aatacgtgaa ctataagaga agacacaaaa aaggacggga acacaaatag gttcccgccg 2394361 tcaaaattgg ctccttggat gaaggggttc tactacatcc taccagcata ggtttaacag 2394421 tgcatgaaga tattgttaaa cctttgtaaa cattaggcgg acttttcagc ggcccgtttc 2394481 agcgtcacgg taaagacagt tccccgtcca agctcgcttg tgacatcaat tttcccttca 2394541 tgagcctcta ttaaatgctt gacaatcgct aggcccagcc cggttccgcc cgaatttctg 2394601 cttctgtctt tatctacacg gtaaaagcgt tcaaagatgc gcggaatttc ttctttctga 2394661 attccgattc cagaatcggc aacctcaatc tgaatgtctt tttctctggg ctttacattg 2394721 atagccacgg agcccccctc aggcgtgtag gttaatgcat tgtttacgag attaagaaat 2394781 acctgtttca gcctgtacgg gtcaccagat acatattgag ggtctttcgg gacattcagg 2394841 tgcaaggaga tgcctttctc atccgcctta tgcttcagaa gcgtttcaat ctcaccaagc 2394901 attttggccg gctcaaacgt ttcgatactg agcgtgaaat tttgctgctc gatttttgag 2394961 agatcgagca aatcctgaac caaagactga agcctttcgc tttccttaag aataatagag 2395021 agaaattcag aaagcgcctc tttgtcttcc atcgccccgt ccaataacgt ctccgtaaac 2395081 ccttttatgg acgtaatcgg tgttttcagc tcatgagaaa cattggccac aaaatccttc 2395141 ctcatctgct ctaatttctt cgtttccgtc atgtcatgga aaacgagcac aattcctttc 2395201 cattcatcgt ccggccccat aatcggaacg ccgtccactt caaaataacg ccgttctatt 2395261 ttgatcggca gtcttaacag cttgcatttc tttgtctccg tcataaaaat gtcttcgaca 2395321 agctggatca cttcttcatg ttcaaatgca tcgtgataaa gacggcgcag catatgattc 2395381 ggattgatat gaaactgctt ggcgtaagac ctgtttacga gattaataaa gcctcttccg 2395441 tcgatcataa tcagcccgga gccaatgttt tcaatgactg tcagcagccg atcccgctgc 2395501 atttcctgcg ttcgcgtcat ttccatcaga tcaatggcaa ggctgttcat cgcatgtcct 2395561 agcttatcag aacgcctaat atagccgccg tacgtccgtg catcgtagtt gcccttagag 2395621 agttctgtgg ctacatttgt cgctgactca attgaccttt tataacgtga ggtcatgctg 2395681 gaataaaaat aaacaatgac gataaatgcg gtacaaagac tggccgtcag catcccccac 2395741 aattcgcctt ttaagccgtc gcttttttca gaggcggaaa gcagcacata tcctgttttt 2395801 tcaccttcgc ttctaagtga aagtccgtaa taaagcttgt tatctgttgt tgacagaata 2395861 ccctcatggc cagaaacaag cgcctgcacc ttttgggaat cagccgatct accgtttgac 2395921 ccatacagca ccttaccgtc tgtatcgata acggatgcgc tcacatcaag cgcgccgcct 2395981 gcatctttaa tgattttctc atttgcttga ttattcagat tgccggcatc aagaagcgaa 2396041 gccaagtatt ttgcttcttt ttcaatgtgt tcctctgctt tcctttgatc agatgtttca 2396101 aaaagctgct gtaaaaacag cccgaggaca caaaacacca gaatcataca gacaacgaat 2396161 acagaaaaaa ggcgcacacg gtatttattc attcattttt ggctcctcca gtttataccc 2396221 caatccccta atcgttttaa tgtagatcgg ttttttggta ttgttttcaa ttttgtcgcg 2396281 aagatggctg atgtgcacat caacaattct cgtatctccg gcaaaatcat aattccagac 2396341 tgcgctcagc agcaggtctc ttgtcagaac tctgccttta tgtctgccta aatagagcag 2396401 cagttcgaat tctttcggtg tcagttcaag ctgactttct ttaaagtacg cttcataatg 2396461 atcaggcagg attttcagat cgccgattac gatctggcct tccatttcat cgttcttcat 2396521 ctcactagag ggcgcagcta tttccgaacg ccttaaaatc gctttgactc tcgcatttac 2396581 ttcccttgga ctgaacggct tggtcatata atcatcagca ccgagctcca gccctaatac 2396641 tttgtcgaat tcctcatcct tcgctgtcag cattaaaatg ggaaacatca gtttttgctg 2396701 tctcagctgc ttgcatactt cgattccgtc caattttgga agcatcacat caagcacaat 2396761 caaatcaggt ttctctgttt ccgctttttt gagtgcttct tccccatccg aggcggtaat 2396821 gacatcatag cctgaccgtt ccaaattgta ctgtaaaaga gtaacaatag attcttcatc 2396881 atccacaact aaaattttct tgttcatgct gtgcctccag tattataatt ccccgacatc 2396941 ctatttctct attttatgtc atcttaacat gtttcatgat tttattttag cgaaagcagg 2397001 acattccgac aattcgcctt ttacatcatt tttaaaagaa ataaagacgt ttatgatagc 2397061 gctttcattt atagtaaaaa gagaaaggct gtattaagca agcctttctc tctttttatt 2397121 aggataatac tttcatgaca tttttgacag attcaactga tttattcagc tgcgctcttt 2397181 catagtctgt cagttcaagt tcaatgattt gctcaagacc gttgccgcct acaattgtag 2397241 gaacaccaag gtagatgcct tcatagccgt attccccttc aagataagca attgtaggaa 2397301 ggacgcggcg ctgatctttc aagatcgctt cgaccatttc tgtcagagaa gccgcaggcg 2397361 cataatacgc gcttccgttt ccaagaagat tcacgatttc gcctccgcct tttctagtgc 2397421 gctccacaat tgcgtcaatc cgttctttcg gaataagagt ttcaagcggg ataccgccag 2397481 cataagaata acgcacaagc ggaaccatat cgtcaccgtg tccgccgagt acgaaaccag 2397541 tcacatcttt cactgacagg tttaattcct ctgccacaaa tgttctgaat cttgccgtat 2397601 caagcacacc tgactggccg attacacgct ctttagggaa gcctgattct ttgtacaccg 2397661 cgtatgtcat tgcatcaaca ggatttgtca gcaccacaat aatagagtca ggagaatatt 2397721 tcacgatttc ctgcgtaacg cttctcataa tcttttcgtt tgtagagacc agatcatctc 2397781 tgctcatacc aggttttctt gcgataccgg ctgtaatgac aacaatgtca gagccggctg 2397841 tatcctcgta attggatgtt cccgtaattt ttgcgtcaaa gccttgaacc gggcttgctt 2397901 caagcatatc aagcgctttt ccctttgtcg ggttctccaa ttgcggaatg tcaacaagaa 2397961 caacgtctgc cagctctttt tgagcgatta aaaatgcagt tgtagctccg gtaaaacctg 2398021 ctccgataac agaaactttt ttacgagtat ttcccatgtc tctcttctcc tttatggcta 2398081 gttttaggct ttttccttgc ttagtccatg tttttgatca gttcttctcc gaactctgaa 2398141 catttcactt cagtcgcccc gtccattaat ctggcaaaat cgtaagttac gactttagaa 2398201 gcgattgttt tttccataga tttgataacc aaatcagccg cttcgttcca tcctaaatgc 2398261 tcaagaagca gaacgcctga aagaataact gaagatgggt ttactttatc aaggcctgca 2398321 tatttaggag ccgttccgtg cgtcgcctcg aaaatcgcat gtcctgtttc gtagttgatg 2398381 ttcgctccag gagcaatgcc gattccgccg acttgcgcag caagagcatc agaaatgtaa 2398441 tctccgttca agttcattgt cgcaacgaca tcaaactcgt ttggacgcgt taagatctgc 2398501 tgaaggaaaa tgtcagcaat gctgtctttg ataatgattt ttcctgctgc ttccgcttcg 2398561 ctttgcgctt tgttggcagc gtcttttcct tgttcttcag caatgcggtc atattgagcc 2398621 catgtgaaga ctttatctcc gtattctttt tcagcaagtt catagcccca gtttttgaag 2398681 gcgccttctg tgaacttcat gatgtttcct ttgtgaacaa gtgttacaga tttgcggcca 2398741 tgctcgatcg cataatcaat ggcagctctg accaagcggc ttgttccttc ttctgaaaca 2398801 ggcttaatgc cgatacctga tgtctcaggg aaacggattt tattgacgtt taactcattt 2398861 tgaaggaagc tgataagctt ttgcacttct tcagagcctt ttgcatactc gatgcctgcg 2398921 taaatatctt ctgtattttc acggaagatg accatatcag tatcttcagg gcgttttacc 2398981 ggtgacggca ctccagtaaa gtatcttaca ggtcttaagc agacgaatag gtcaagctct 2399041 tgtctgagcg ctacgttcaa agaacggata ccgccgccga caggtgtcgt taacgggcct 2399101 ttaatcgcga tgaaatattc gcggatcaca tctaatgttt cagcagggag ccactcacct 2399161 gttttattat aagccttttc tccggcgtaa acttctttcc atgtaatttt cttttcgcct 2399221 ttgtatgctt tttctactgc tgcttccaaa accttcgaag ccgcgttcca aatatcagga 2399281 ccggttccgt ctccttcgat aaatgggata atcgggttgt ttggtacgtt taatactccg 2399341 ttagagactg taattttttc accttgtgcc acaataaaaa cctcccagta tgtaattcat 2399401 atttagaaaa cattttattt ttcttatata gaaaataaaa tgatttttcc taacattcaa 2399461 tttaaagtgt aacccaattt tgatgtctga acaagaggct aacctcattg acgcaagcca 2399521 gcctccaatg gttctttagg ctctttcttc aatcggaacg aatttttgtt tgtcagggcc 2399581 tgtgtaatct gcccgcgggc ggatcagacg gttgttgtca tactgctcaa gaatatgagc 2399641 gagccagccg gacattctgc ttacagcaaa aatcggtgta aacaaatcat ggtcaatacc 2399701 gaggctgtga tatacagaag ccgaatagaa atcaacgtta ggcggaagct ttttctctga 2399761 tgtgacgatg tcttctatac gaatcgacat ctcataccat ttgctttcgc ctgtcaggtt 2399821 ggtcaggcgc ttgctcattt ctttcagatg cttcgcgcgc ggatcaccat gcttatacac 2399881 acggtggccg aatcccatga ttttttcttt cttttcaagt ttagcgcgga tgtacggctc 2399941 agcgttttcc acttcaccga tttctgtcag cattttcata acgccttcat tcgctccgcc 2400001 gtgaagaggc cctttcagcg cgccgattgc tgcagtaatg cctgaataga tgtcagaaag 2400061 tgttgcgacg cagaccctcg ctgtgaacgt tgacgcgttc agctcatggt cagcatgtaa 2400121 aatcaatgct ttgttgaagg cttcaacttc aattggtgaa ggctcttcac cgtttaatgt 2400181 gtaaagaaaa ttctccgcaa taccgtaatc ttctctcggt tcaacaggct caagaccctt 2400241 gcgaattctg gaaaacgctg caaccaggcc aggcaccttt gcctgaaggc ggatcgcctt 2400301 tctgtagttg gcttccgggt tcatggtatc agcctcgctg tcaagcaggc ctagtaatga 2400361 aattgctgtc cgaagagcag ccatgggatg aacattttcg agggaataag atttgaagtg 2400421 ctcaataatt tcttgcggaa cggcagcttc ctttgcaagc tgctgcttta actcttcaag 2400481 ctcttttttg tttggcagcc ttagatgcca aagcaagtag atgatttctt caaaacttgc 2400541 attctctgtc aaatcatcga tatcataccc cacatatgta agggtatcat caataataga 2400601 actaacagat gatgttgttg ctacaacccc ttcaagaccg cgtgtcgctg tcatatataa 2400661 catctccttt tcaataaatt tcccctttaa gagtgttgta aaaacatgag gcttacttaa 2400721 aaagcacgat gcaagtattt ctctccccca aaaagaaaat gcttacattt tactggctgc 2400781 tggaactaaa accctttgct tttgaaagaa cataacaaat ttttataagc ttatttaagt 2400841 ttaagcctat tctcattata aacaataatc agacatttgt taaatgttta cctataattt 2400901 tttttttcca ttctgtgatt tccccgaaaa aacgccttta tttgcgggtt tttgcataaa 2400961 aaaaagcggc tttaaggccg ctttttttta tgaagtgaac agttttacga tctgcatggc 2401021 taaataagca atccccgctc cgatcagcgg ccccaccgca actcctccaa aaagcgcgac 2401081 tgcaagaatg gtcccgatca cgagagcagt tgtaatatgc ggatcatttt caagcagggt 2401141 caggccgttt tttgcaatca gcgccactgc gatccccgct ccaagggcga tccatgcgta 2401201 ggaagaccgc attgcttctc caagctgctt aaatccgatt tctcccgtgg caatcgggac 2401261 aagaacggcg atggtaataa tggtcacacc ccagttaatg ccttttgact ggatggtcgg 2401321 aaataatttc tgatcaagcc caacgatttt gatgatcaaa aggacggata cagcaaagag 2401381 caatgattgg ttttttgcga taagtgcgat agccaagagt aaaattaaaa ataaattcgc 2401441 ttgtgtaaac acatgccatc cctcctttaa gatgaatgta ttcatattca gccgcagcgt 2401501 gaatacatat aaaaaatagg acatgctgac gagaggagga ccgtttttgt gaatcaatct 2401561 tatatcacta tttttttcag aaccctcttt gtcatatcaa tgaccgcagg gtcgatagct 2401621 gcggcctatt attcgtttcc gttaacttat ccgttcctga tcgcccttat tctatcttca 2401681 gtgattcatc ctgttgtcga ttatttggac aaagtgacag gattcccccg aacgataaat 2401741 gttctgggcg ttcttgcttt ttttctgctc gcagccttcg gcgtgctcac cattctggta 2401801 gccgaaatcg taacgggaac agcctatcta gcaaaaacgc tgcctccgca tatcagcacg 2401861 tttatttcat attgcgaaaa attgtttacc actcatattc agccgctcta taacgagtta 2401921 actcttttgt ttcaagaatt ggaaacgaac cagcaggctt ccatcgtcac tcatatccag 2401981 acactcggtg attctgccgc taaaaatgcc gggctcctgc tgtcccacat tctagagatg 2402041 atcccgagat ttttcgctct tcttcccaat acggcggcgg ttctgatttt ttctcttctg 2402101 gcaacctttt ttatgacaaa ggattggcat aagctgaaag ccatgcttgt tttaattctg 2402161 ccggatcgtg tgacagctaa cagcaaagca atcagcagcg aattaaaaaa agcaatgact 2402221 ggttttatca aagcacaagc cgtcctcgtt ttcatcacga tggtgattgt atttatcggc 2402281 ctttctctct taaaggttga acacgccgca acaattgctt ttttaatcgg gcttgtagat 2402341 cttctccctt acttaggtgc cggctccgta tttgtgccct ggattttgta tttatcgatt 2402401 acgggccagc tgccccaagc aatcggaatt ggtatcctgt acctcgtcgt tcttattcag 2402461 cggcagctga cagagcccaa gatactaagt aaatctatcg ggatcgatcc gctggcaaca 2402521 ctcatcgccc tgtttgccgg ctttaaatta ttcgggtttt taggactgat tgcgggaccg 2402581 gctgtactcg tcatcatcca agctttcatc acaacaggcg cattaaaaga aatatggtcc 2402641 tatatcaccg ttcagcaaaa ataaaacggc agccgttttt tcatggctgc cgttttttat 2402701 ttgatgatga tccgcttatt cttcgacatt cctctcagcc atttgaacag aatcggctta 2402761 caccagccgc gggtaaacgg gataagaaga caggcgccgg ccaaatctga taaaaagccc 2402821 ggaagcatca gcaatagacc gccaatgaaa atgcacagac cgtcagcaat cgcttctccc 2402881 ggcattttgc catattgaag atcacgctga accttataat acacttcggt tccttgtttt 2402941 tttgcagctg ctgcgccgat aatgccagtc agaatcatga atagaactgt cggcaaaata 2403001 ccaatcagat ttcctaaaaa taggaatata ccgatttcta ttgccggaaa cacaataaaa 2403061 agcaaaaaca aaaatctcat atccaagccc cccacacgtg taacacgttc tgttcaacaa 2403121 aaggcatgat aaagagaaaa ggaagggatt ccccttccat tttcacctgt aattaaagaa 2403181 cgctcgcacg gccttgatag actgcgcctc tggaagcgtc aactgtaata tcctggccat 2403241 ctgtcaaaat agatgtcgca ttttccagac ccacgataac cgggatgcca aggcttaatc 2403301 cgactaccgc agcatggcta gtcaaaccgc cttcttctgt aataagagca gacgcttttt 2403361 caagggatgc aatcatatca cggtcagtgc ttttggtaac aagtaccgca ccgtcagtca 2403421 ttttttgctc agcttctttt gcattttgtg caacgacaac cggaccgtaa gctgatttgc 2403481 gtccaatgcc ttggccttta gcgatgatat cgccgacagt atgaaccttc attaagttcg 2403541 tagtgccgga ctcaccgaca gtgccagctg taataacgat aagatcgccg tgttttacaa 2403601 ttccgctgtt caatgatttt tggacagcat cctcaagcat ctcatctgtt gagctcgcat 2403661 tttggccgct ttccgcgaat acgccagata cgagggcaag ctttctggaa atagagtcat 2403721 ttacagtaac cgcaacaatc ggagcctgcg gacggtattt tgcaatcata cgtgctgtat 2403781 ggccgctttc tgtcggcgtt acgatcgcag cagcattcag gttaatcgcc gtatgtgcga 2403841 cagattgtcc aattgcgtct gtaattgtca tgcccacttg gtctctgcgt tttgagagaa 2403901 tttctttata atttaatgct tcttcagaac gggacgcgat gttatgcatt gtttgaactg 2403961 cttcaaccgg gtaacttccg gcagcagttt caccagaaag catgatcgca tctgttccgt 2404021 cgaagatcgc gtttgcaacg tcacttgctt ccgcacgagt cggacgcggg ttgcgctgca 2404081 tgctgtcaag catttgtgtc gctgtaataa caggtttgcc cagcgcgttg cattttttga 2404141 tcagttcttt ttgcacaagc ggcacttctt cagctggaat ttccacacct aagtctccgc 2404201 gtgcaaccat taagccgtca gacacttcga gaatcgcatc gatgttgtca acgccctctt 2404261 ggttttcgat tttagggatg atttgaatat cctgagcgtt gtgctcttca agaagctcac 2404321 ggatttcgag cacatccgta gaacgtcgaa tgaaagatgg tgcgatgaag tctactcctt 2404381 gctcaatacc gaaaacgatg tctcgcgcat ccttttcagt aatccccgga agattgacac 2404441 ttacgcccgg tacgttaaca ccttttttat ttttgagtgt tccgttgttt aatacttttg 2404501 ttttgatttc gcgtttagcg gcatctacat caagtacctc aagaccgata aggccgtcat 2404561 ctaacagaat cgttgaacct tgttcaacgt catggactaa accttcatat gtcactgaaa 2404621 ttttatctgt tgttcctaca acctcgtcca ttgaaataat gagctctttg cctgtttcaa 2404681 gctcaatacc gccgttttcc attgtatgtg tgcggatttc aggacctttt gtatcaagca 2404741 gaattccaac gttcttgcca agttttttac ttgcttcgcg gatattttta attcttgcac 2404801 cgtgctcctc aaaatctccg tgagaaaagt ttaatcgagc cacgttcatt cctgactcca 2404861 ttaatttcgt aagcatttca atactttcac ttgccggacc gatggtacaa acaattttag 2404921 tttttctcat ttggttcact tccttctgaa atcttcagcc ttcagctgta cattagatag 2404981 acagttcttt tgaaagctga tacatgtttt gctcaactgt gtgttttgtc tcaagtattt 2405041 ctataatatc atggtctaca agcttattgt tttgtatacc tacacagcgt ccgccttttc 2405101 cttcaagcag cagttcaact gcatatgcgc cgagacggct tgccaacaca cggtcagcag 2405161 cactcggaga acctccgcgc tggatatggc ccaatacaga taccctagtt tcaagatttg 2405221 tttcttcttc aatgcgtttc ccgaattcaa caccgctgcc tacaccttcg gcaacaataa 2405281 taatactgtg cttcttgccg cgttcgtggc cgcgttttaa gcgggcaatg atttcgtgca 2405341 tgtcatagtc tgcctcaggg attaagatcg attctgcgcc ccctgcaaga ccggcccaca 2405401 atgcgatatc gccggcatga cggcccatta cttcgattac atatgtacgt tcatgagaag 2405461 tcgctgtatc gcgaatctta tcaattgcgt caattactgt atttaaagct gtatcgaaac 2405521 cgattgtaaa atcagtgccc ggaatgtcat tatcaattgt acccggtaca cctacacatg 2405581 gaaacccgtg ttccgttaat tttttcgcac ccatatagga accgtctcca ccgataacaa 2405641 caaggccttc aataccaagc ttcttcaagt ttgctatccc tttttcacgg ccttcaactg 2405701 ttttgaattc aggacatctc gccgtataaa gcttagtccc tccacgatgt ataatatcgc 2405761 ctactgatcc gagttcaagc ttttcaatct ttccgctgat caatcccgcg tatccgttgt 2405821 aaataccgta aacttcaacg tcatgataga tcgcttttct gactactgcg cgaactgctg 2405881 cgttcattcc cggggaatcc ccgccgctcg ttaatacccc tattcgtttc attctccatt 2405941 cacctcagca acatatatga ttaaacataa catgatcatt gccctaaaaa caatgaaaag 2406001 ggatctccat cctccctatg aaaccttacc tattatacaa ttaaataaat tgtttttaaa 2406061 taaaatttaa ggaatgtcac aaaaaataaa cgtgagccaa aggcttcacg tttatttagt 2406121 ttaccccgat atattgatct tcaaccgaga ctttgccaat tgctttatat ttttcataac 2406181 gctgctgaac taattcttct tcgctcagct tcagtaaagt ttttaacgat tgtttaaggg 2406241 tttcgtccat atagcttgcc tgcagcttca catcatggtg cgctccgcct tttacttctt 2406301 taatcatatg atctataata cctaattctt ttaaatccgg cgcagtgatt ttcattgttt 2406361 ctgctgcttt tttagcaaga ctggagtcct tccataaaag tgccgcggca ccttccggag 2406421 aaataacaga ataagtagag ttttccagca tatgcaagtg attgcctaca cccagaccaa 2406481 gggctccgcc gcttccgcct tcaccaatga cgatgcagat aacaggcact cgaaggccgg 2406541 ccatctcaaa caggtttttg gcaatagctt cactttgtcc tctttcttca gctgctcgtc 2406601 cagggtatgc ccccttcgta tcaataaaac agataattgg tctgttaaat ttgtcagcct 2406661 gtttcatcag acgaagcgct tttctgtagc cttctggatg cggcatccca aaattgcgga 2406721 ctaggttttc cttcgtgtct ttgccgcgct gatgcccgat taccgttaca gggaggccgt 2406781 ggaacttcgc aatcccgccg acaatggctt catcgtcccc gtacgctctg tctccgtgac 2406841 attcaaaaaa gtcggtaaac aggtgttcga tataatcaag agttgtcgga cggtccgcca 2406901 gacgcgcgat ttgaacccgg tcccacggct tcaaattttt gtaaatatca tcctgaagct 2406961 tagcgagacg gtcttcgagc cgttcgattt ccgcacttag atccatatcg gaatcttggg 2407021 tgaatttttt tagttcggcg attttggttt gcagttcaat caccggtttt tcaaattcta 2407081 atcttggagc cactcaatgt cacctcctgt ttgatgcata tccagcagat tttctaacgt 2407141 ttttttcata tcgtcgcgat gaataaccgc atcaagctgt ccatgtttta ataaaaactc 2407201 agccgtttgg aagtcctcag gcagtttttc tcctattgtc tgttcaataa tccgtcttcc 2407261 ggcaaaaccg atcagcgcgc caggctcagc gaaattgtaa tcgccaaggg atgcaaagct 2407321 tgctgatacg cccccggtag tcggatgcgt cattactgaa ataataagac cctgttcttc 2407381 actgaacagt tttaacgcag agcttgtctt tgccatctgc atcaaactta atacgccttc 2407441 ctgcattcta gcaccgcctg aagccgtaaa aataataaac ggaactttat cagcttttgc 2407501 tttttcaatc gcaagcgtga ttttttcacc gacgactgaa cccatgctgc ccattctgaa 2407561 tgaagagtcc atgacggcga caacagccgg gtgtccgccg atggtgccct tgcctgtcac 2407621 aacagcctcg tttaaggatg ttttctcgcg atctttttca agcttttcca gatatcccgg 2407681 gaaaccaagc ggattttccg agagcattcc ctgattaaat tcctcaaagg attgttcatc 2407741 catcaagctt tcgatacgct gttttgcgtt cattgggaaa tgataatcgc agttcatgca 2407801 tacccgcata tttttatcca actctttagt gagcatgatt tttttacact taggacattt 2407861 tgtcataatg ccttccggaa catcgtgctt cgcttgatca gacggtacgg aagcatactt 2407921 tttctttttc gtgaatatat cctttaacaa atgattacct cccttttgtg aagggttctc 2407981 ttcaccgcat gtcatcaaac agatagactt gctaataact ttaccgaaac tattgtactt 2408041 tttttgtcaa acgctgtcat cctcaattcg acaacttttt attcgatgac gtgctcggaa 2408101 aggcttgtat gaaatcagat aaggtgttga aacgacaagg ttgacagcgc attcaaaaat 2408161 aatgttaaac ccggctgaaa tttttttaag gctaaccccc taaaaaaatt tcagccgtca 2408221 gtttaacttg agaacagcgc gccggtctcc gccaacgcgc tgccattttt ggaatgaatt 2408281 aaaattattc accaataatc gtaagttttc ttgttttttc tgcgacttcc tcagggtcaa 2408341 cagtgattct tgcaacacct gtttccatcg cagcttttgc cacagccttc gcaacagcag 2408401 gcgcaacacg tttatcaaac ggtgcaggga tgacatagtc tgcgctaagc tcatcttctg 2408461 aaaccagtga agcaatggct tcaaccgctg cgattttcat ttcctcgtta atatgagtgg 2408521 cacgcacatc aagcgctccg cggaaaatac cagggaatgc aagaacattg tttacttggt 2408581 tcgggaagtc agaacggcca gttccgacaa cgcttgctcc ggcttcacgc gcatcttccg 2408641 gcatgatttc cggatttgga tttgccattg caaagataat cggatctttt gccatgcttt 2408701 gaaccatttc ttttgttaac gcgcctgcta cagagacacc gataaatacg tcagcatcaa 2408761 cgataacatc tttcagagaa ccgtctttgc gatcttggtt cgtgaacttc gccacttcat 2408821 ttttgacatc gttcatgccg ttcgggcgcc cttcataaat ggcccctttg gaatcgcaca 2408881 tcacaatgtc gcgaacgcca taatgatgaa gaagcttgat aatcgcaatg ccagccgcac 2408941 ccgcgccgtt tgcgacaact ttaatggatg acatggattt tccagacagt ttcagcgcgt 2409001 tcacaagacc tgctacggtt acaatggcag taccgtgctg atcatcatgg aaaaccggga 2409061 tgtttgtttc ttttttgagg cgctcttcaa tgataaagca gtttggcgct gcaatatctt 2409121 caaggttgac gccgccaaat gtcggttcca gcaattttac agtttcaacg attttatcaa 2409181 catcgtttgt gtttaaagca atcgggaacg catctacgcc cgcaaagctt ttgaaaagaa 2409241 ctgctttccc ttccataaca ggaagcgccg cttcagggcc gatgtttcca aggccaagca 2409301 cagctgtacc gtcagttaca actgctacca tgttcccctt cattgtataa tcatatactt 2409361 tgttaatgtc ttcatgaata tccttacacg gttctgcaac acccggagaa tacgcgaggc 2409421 ttaaatcttt cgcatttctg acctctactt ttgatttaga ctccagtttc ccctggttga 2409481 ctttatgcag gtgtaatgct tcttctctta atgacattct cctaaacact ccttatggat 2409541 attttttgat tcgtatactg ctgcgttgat tgctgcattc tgcggagtaa atctatctga 2409601 atatttaaac aggatcacat aattgctcca attgtataac aaaaagcgaa tcgttaccac 2409661 tgttttaaaa cgacgttttt ttgacccaac agctctttta agcgatataa cacctggtga 2409721 tctgcattga tatggaacga ctcaggtagc ttaatcgtct gtttttgcct ttcataatag 2409781 agataaacgc ctgtttcccc tttatgctcc agcaaaatgc gcttaatctt tgccaggatc 2409841 tcctggctgt gctgactgct ttctattttt atataaaccg atggcgcttt ttctgcatcc 2409901 atatcttcta ataattctgc ccgggacatg atgaattgga tcttatcttg tctaacttca 2409961 catttccccg cagtgaacaa aagagcgcct tctcttaaaa cgggagaaag ctgtctgaat 2410021 tgttcaggga agactacggc ttccatctcg ccggtttcat cactgagcgt taaaaacgcc 2410081 atgttttgac ctgttttcgt ccgaatcgtt ttgatcttcg acagcagaac gcctagtgaa 2410141 agctgccttt tgactgcccg ctgagcctgc agaatggaga ctgctccttg cgcagtgagc 2410201 tgttttcgga aggcggagag gggatgattt gaaaaataaa tgccaagcgt ttccttttca 2410261 aacgcaagta aatccaccag aggaagctcc tccgtctcca catacttcgg cttaattgaa 2410321 aacgattcat ctaaaaacaa tcccatttgg tcatcgtccg cggcgaatag ctcagcatgt 2410381 tccaaagcaa catcaatgga tgcgagcagc gtggcccggt tttggccgaa ttcgtccatc 2410441 gcaccagaaa agataagtgc ttcaagcatt ttgcgattta cgctttttga cggcacgcga 2410501 aagcagaaat cgaaaagatc ttcaaatggt ttctcttttc ttgctttata tatatctttg 2410561 actgctgaga cgcctacact ttttatcgcg cggaggctgt atctgacaga tccgttttca 2410621 actgtaaacg gaaaactgct tttattcact gacggaggaa ggatacgaat cccgctcccc 2410681 tttgcttcgt aaagatattg agagatttta tcctcattgc caatgacgct tgtcagcaat 2410741 ccgcacataa aatataacgg ataatgagct ttcaaatacg caagctggca cccgatcatg 2410801 ctgtatgcca ccgcatggct tctgttaaag ccatagtttg cgaatttgac gattaaatcg 2410861 tagacctcat ttgcagtgtc tacagaatac tcctttttta agcacccttc aacaaaatgg 2410921 cttcgctctc tgtccaggat ttcttttttc tttttgctga ccgcccttct caataggtcc 2410981 gcttcgccta aagaaaaccc cgccatacgg gaagcaatca tcataatttg ttcctgatac 2411041 acaatgacgc catatgtatc ttccaaaatg ctccttaaat cttcatgagg atagtgaaca 2411101 ggcgcccgac cgtgtttacg gtcgataaat aacggaatat tttccatcgg acccggccgg 2411161 tacagtgcat tgaccgccac aatatcttct aggcccgaag gtttcagccg tttcaagacg 2411221 cttctcatcc ctgcagattc aagctggaaa atgcctgtcg tatccccttt tgacagcaag 2411281 gagaacgttt tgtcatcgct gtaggaaata cttgaaaggt ctattttaat attttcttct 2411341 ttttcaatca ttgaagtgat ggattcaata agtgtcagat tcctcaaacc taagaaatcc 2411401 atttttaaaa ggcccaagtc ttcaagatgg tccatcgcgt attgcgttaa atagatccct 2411461 tcatgccctt cttgaagcgg aacaacatct gttaacggtt cttcactcag gacaacgccc 2411521 gctgcgtggg ttgatgcatg ccttggcagc ccttctattt tccgggcaat tgaatagact 2411581 tgctgaagca ggcttgactc ccgaagccgc ttatccagct gcggtgactg ctgtctcgct 2411641 tcatccagcg tcattcccgg tcttgaagga atgagttttg caagctgatc tgcctccttc 2411701 gggctgacgc cgaatactct gccgacgtcc cggagcgccg cctttgccgc aagtgttcca 2411761 aaggtgataa tctgtgcgac gtgcattgca ccgtatttct gctgaacata ttgaatgact 2411821 tcatcccttc tagtatcggg aaagtcaata tcaatatccg gcatgctgac gcgttcggga 2411881 tttaaaaatc tttcaaacag aaggtgatgc ttaatcgggt caacatctgt gatatacagc 2411941 acatatgcca caagagaacc cgccgcagaa ccccttcccg gtcctgtaac aatccctttt 2412001 tcatgggcgt gcttcataaa atcccacacg atcagaaagt aatcgctgaa cttcatccgc 2412061 ttgatgacat caagctcata ttgaagacgg cgaaggtatc gttcatcagg cttgccgaaa 2412121 cggctgcgga gtccctccat acagatatcc gttaaataat catcagcgga cgttccgtct 2412181 ggggtcggaa aagacggtag acgggtctgc ccgagactga cgtcaacccg gcattgttcc 2412241 gcgatctcta cagaagcttg cagtgcctcg ggatgctctc gataaatgtt ttgcatttct 2412301 tcgagtggtt tcaaatcgag atcaggcaaa tcttcagcgg gtgcatccgt cagtttttcc 2412361 cccgctttaa tcgctttcaa acaacggtag gcagccttat cttccttcct tatgtaatgc 2412421 acatcgcctg tggccgtaac agggataccc gtttcttctg acagctttag aatctgctca 2412481 gacaagactt gattcccttt aaaaggctga taggagaaat aaaaagctcc ctttccgaat 2412541 atagactgaa attccagcga ggcttgagca gcctgttcga acagccctcc ttcaagaagc 2412601 gtttcaatat atcctttttc gccgggcgtt attgcgataa tcccttctcg ataactgtga 2412661 agccatttcg gcttcagtcc gccttttgat ttagattgca gaacgctgct gattttcagc 2412721 aggttttgat agcctgtatt cgattttgcc agcaggacga gcgggtatgc ttcaagctcg 2412781 ctgtcatctg taaaaacaga agccgtcaaa ccgattattg ggttgatccc tctcgccttg 2412841 caagctttat aaaattgaat agctccgtac atgacatgat catctgtcag cgccaaagac 2412901 gcatatccga gcctgtcagc ttcactgacg agttcttcca cagccgcggc gctgtttagc 2412961 aggctatacc cgctatgcac ttgcaggtga acaaaagaca tgctatcacc tctttctcat 2413021 tacgatccat ttcttccttc attataaggc cggtttccaa aagaaacaaa tgttcttttt 2413081 tgactcatca tcatacttgt cctgaaagct caatatgata taaaaggtga ggtgataaag 2413141 atggatcagg aagcaggatt tatggtgaat tttatcaata gctacttcat tgcgttaggg 2413201 gtgctgatcg ggggcgcact catcggaggg ctcggagcat acttggcagg cgaacccccg 2413261 cttacagcca ttacaaagct tgccaaccgg ttaaaaatat gggcgcttgt cgcagctatc 2413321 ggaggcacct ttgatgcggt atacagcttt gaacgcggca tactcgaagg caatacgaga 2413381 gatatcttta aacagcttct tttaattatt tcggccatgg ggggcgcgca aagcggctgg 2413441 cttattatat catggctgac ccaggagcat ctttcttcat gagggtcccc cagcattaca 2413501 aaaaaccggg atggcagcgt tttttcgcgg gaatgatgtg cggagccgta atcagctggt 2413561 tctttttcct gtttacttac ggaacattcc aagaggagca ggtcagcctc atcgaaaagc 2413621 aaaaagagca tgtaaaagac ttgaacaatc aaatttcgat ctatcaggaa gacctccata 2413681 aactgaatga agataataaa agaaaactgc tgattcaaag cgtcagcgtc aaattgctga 2413741 atggggataa atataaaata tcacagccgg ataaaacgaa attcgaggag catgtaaagg 2413801 atgatatttc agaggtgatt acaaaagaca tagagagcgt ctatcaaaca aaggatctct 2413861 tgaagcggac aattgaaaat aaagtctata tgatcaatga aaaaaaatac gaggcaaccg 2413921 tcagagaatt gattatttat acgaggctga cagtggaact tgaaatttct ttcgccacat 2413981 aattatggat tttttttaaa ttctccaaac ttctgtcgct ttttcccatt cttttttata 2414041 aactatatgt gaggcttaat ggcgaaagga aggaggaagg gaaatggagg tttacagtga 2414101 ccgtcagtta gcaaaagatc aagcagcccg tctcagacaa ggtttttctg catatgccga 2414161 aacaaactca ctcgcttccc tcatcaaaaa agaacttcaa tcacacaatc tccaagtcta 2414221 cgaggacctt actgatttcg gctgctggtt catccccgtc acagatgaac actaagagag 2414281 agggtctccc ctctactcgt gttctttaca taatgtttcc agatcagcta aaatacgatc 2414341 agcttcatcc cagctgtaaa tagaggcgcc tgaagctaac ggatgccctc cgccgttata 2414401 tttccgggca agtccgttaa tgacaggccc cttcgaacgg aatctgactc tgatttgatc 2414461 gtcttcttct acgaaaaaca cccaggcgcg aatacctgag atattgccaa gcgtcccgac 2414521 aagctgcgac gcttcagaag ccgttgtgcc gaatttttca agcgtatcct ttttgatgaa 2414581 aacagaagcc gccccgtttt cggacaaaga cacattttga aagataaagc cgttaagctt 2414641 caccacattc agttttgttt catacaattg attaaataac tctgaggaag agaatggata 2414701 ctgaatgagc tcgcctgcat attttagtgt tttttccgtg gtattcggaa ataaaaagcg 2414761 tccggtatct ccaacaatgc cggcgtagat cagctctgcc gctttcgtat tcagcttcca 2414821 gccgtgctct tttccttcta aatacagctc gtaaatcatt tcacttactg agctggcgct 2414881 tgtatcgacc cagagaaggt caccgtatgg atcttcgttc ggatggtggt cgattttcat 2414941 tagtttggcg cctgaaggat aacgctgatc gtcgattctt tcctgatttg ccgtatcgca 2415001 gacaatgaca agtgcgcctt catatgtttc attgtccacc tcatcaaggg aatataagaa 2415061 agagagggac ggttcaggcg tgccgaccgc aaaaatattt ttttcaggat atgtttcacg 2415121 caggatttcc gtaagcccac actgtgatcc gtaggcatcc ggatcaggac gcacatgtct 2415181 atgtaagata atcgtgtcat ataatgatat ggttctgatc aattctgttt tcatttgata 2415241 ctcctttatt gtttttattc attaaatcac attctctgcc gacggaaaag aaaaataacg 2415301 tcaaaaccaa gcccgttttt gtataaaatg gggttgtaaa cttttacgat ggaggatttc 2415361 atttatgctg gttcttgttt ttttgattgg gctttcagcc tgcttttatg tgtactataa 2415421 agtaaaaggc gtacgggcaa agccatcttt ggcaaaagaa atatgttcag caaaatcaag 2415481 catggcctta gggtcactag tcctgttcta cgggcttaac caaatgatat tattccattc 2415541 agtattaacg ttagtaatcg gcggtatctt tatcgtcata ggagcaggaa gcgcttgggc 2415601 aggttataaa gccttcaggc attacaatcc ccttcacgcc aaagaagctg aaagagatca 2415661 cgcgtaaggg gcgcctgaac gtcccttagc ttctttccat cagctgaacc atcagcatcg 2415721 ctttagacac gatatgacct tggctgtgca cttccacttc cattttccca aactttctgc 2415781 cggcctccaa gatgcgaggt ttgacttcga tgactgattc catctgcaca ggcttcaaaa 2415841 agaagatggt gatgctctct atgacgagtt cgccgcgttt tttcgagcgc aaaaatcggt 2415901 ttgccgcttg cgtcaaaatg gtcgtaaata cgccataaga aatggttcca agctgatttg 2415961 tcatttgcgg cgtgacttca tactcgtaaa ccgtttgatc ttctttatca tcaccctcat 2416021 ctttaaaccc ccttgaaacg atatcatcaa gcttctcccc gacctgcggc tgcttttgaa 2416081 tcatttgaag agctttcaat acgtcttggc ggctgatcat gccgatgagt ttttggtggc 2416141 cgtcagtgac gggaagcact tcgatccctt cccataccat catttgcgca gctgaagcga 2416201 cagatgtttt cccaataacc gtgacgggat ttttggtcat gactttttct atagatgcat 2416261 ttcggtcatg gccagcaata tcttttgatg tcagaatgcc atggattttc atttgatcgt 2416321 cgacaaccgg gaagcggccg tgccccgttt caaaattttt ctcataccat ttttcaagtt 2416381 tatccttagg cgaaagatat accgtgcggt cagcaggtgt taggatgtcc tccaccaaaa 2416441 caatttcttt tttgatcagc tggtcatata ttgcccggtt aatcatcgcg gcaactgtaa 2416501 aggtgtcata gctcgtggat aaaatcggca gttcaagctc atctgccagc tgcacaatgc 2416561 tgtcatccgt gttaaagccc ccggtcacca atacggccgc gcccgcttca agcgcctgcc 2416621 tgtgtgcatt gattctgttt ccgacaatca aaagattccc cgctgcggtg taacgcatca 2416681 tcgcgtcaag ctccatcgcg ccgatgacga atttattcaa tgtcttatgg agccctgccc 2416741 tgcctccgag cacttgtccg tctataacat ttacaacctc tgcataggta agcttttcaa 2416801 tgttctcttt tttcttttgt tcaattctga ttgtgcccac acgttcaatc gtgctgacaa 2416861 accctttatt ctctgcttcc ttgatcgctc tgtacgcggt tccttcgctt actttcattt 2416921 cctttgcaat tcttcggaca gaaatttttt caccgacagg cagtgaatcg atatacgtta 2416981 aaatttgttc atgcttcgtt gccaagcctt tcacctctaa ggacagtctt cttgttttta 2417041 ttataaggtt tcaaaggatt tatacgcaat gaggctggaa aataaaaaag aagcccgacc 2417101 ggcttcttac agcgttgatt tcgttccagt caaacgcaag gaccacgtga ttccttttac 2417161 atcgtaaagc ggaaaaacct ttatttttct tttaaatgga catcaaccgc tgtcttaaca 2417221 atatttcgat tccctatttt agataaaaca aataaaactg cggatagcca tatcgcccct 2417281 atggccgtat agatcaatgg atgaacagct gtgtttgcga tccattcatt tattaatgtt 2417341 ctggcattta ccagaataat aaatcctcct acaagcacac ccatcaattg cggatgaaac 2417401 ttctgcacca gccatgctgc gataggggca gcgataattc cgccggccat tagtgaaaac 2417461 acccataacc aattgacgtc ctcccatcct aatgaaataa gaaaaccggc ggttgcagat 2417521 acggcgatgg caaattcact tgtgtctaca gtcccgacaa ctttcctcgg gctcaagcct 2417581 ttgcgggata ataaaatcgg agtggtcacc ggtccccagc cgcctccgcc tgtggcatct 2417641 gcaaaaccag cgatcactcc caatgggatg gattgttttc ggtttaacgg cacatgcttc 2417701 ttctcaagag ccggcttata ttgaaataaa aacctgatca atacatatcc gcccagaagg 2417761 agcaaaaaca aagaaatata gggtttcgcc acatctccag gtaattggct gaggaatgcc 2417821 gcgcctaaaa aagcgcctat agagccggga atgacaagct gataaacggt ttgtttgtca 2417881 acattgccaa atttaatatg cgacactccc gatgcggcag tcgttacgac ttccgctaaa 2417941 tggacagaag ccgaagccac agcaggtgtg atgccaaacg ccaataacaa agaagttgag 2418001 gtaaccccat aagccatacc taacgaaccg tctattaact gcgacaataa accaataaat 2418061 gcaaaaacga ttaatttctt catcagaaca ccccatctat atcaatcaga tatttttgac 2418121 tcttcattcg aatctaacaa tctcttggcg ctttcatata aaaaataaga ggctttgata 2418181 attgcagttt catctattgt aaatgcaggg tggtgccaat catgatcacc gtctgttcca 2418241 aaaaacgcaa aggatcccgg aatatgctca agataataag caaaatcttc ccccgcggtt 2418301 gatggggcgg gatcaatgac ttgaagtttc gctttatgtg cagcgtctcg caccagcccc 2418361 gtaattgcct catcattaca aagcggcggc ggtccggaat gccacttcac atttgccttt 2418421 aacgagaaag cggcagaaat ctgctctgtg actgcaaaaa aacgctgttt cacttgatta 2418481 cgaacctctg aatcaaatgt acgaacagtg ccctcaatga ccactgtatc cggaatgaca 2418541 ttccaagtgc tgccgccgtt gattttccct acggttaaaa tcgcgctttg cagcgggttt 2418601 acatttctgc ttacaatcgt ttgcagggcg acaataagct gagaggcgcc gataattgga 2418661 tcaaaaccat tatgcggcaa tgctgcatga gcacctttcc cttctatctc tactttaaat 2418721 cggtcaacag cagccataag cgggcctgtt tttaacccta cagtcccaac cgcgatatcc 2418781 ggtttattgt gaaggccaat aaccgcatca atgccatcca gttggccgtc ctctatcact 2418841 tttgtagcgc ctgcacccgc ttcctctgct ggctgaaata ataaacgaat ctttcctttc 2418901 agactgtctt gattttcctt caataaaaag gccgcaccaa gaagcgctgc cgtatgaaaa 2418961 tcatgaccgc acgcatgcat gatcccttta tgtttagacg cataaggcaa tcctgttttt 2419021 tcttcaattg gcaaggcgtc aatatcagcc ctcaaagcaa tcgccggacc ttctgactcc 2419081 cctgctatgt ctgcgaacac acccgttttt agagcagtag ggcgaatctg tatccccttt 2419141 tctttaaggc atttttttat aaaagcagtt gtttcaaatt cttcttttga cagttcagga 2419201 tattggtgca ggtgccggcg aatgccgatg agctgctttt ctagcgttga gagatttacg 2419261 ggattagact cctctttcaa cgtcaggatg tcatttcctg tagtctgata tggataggag 2419321 ccttctatat ttctccaata atccaaagac atatgttccg ctcctttccc tatcccaata 2419381 tattttcttc agactcttca acataagatg aaataaatcg gttcaattta tcagcaagac 2419441 cgcccgcccc aaatcttata tacttgctgg aaactttcgg attatcttct ttcaaaaagc 2419501 ttaaaaaaga taaaatataa atgcgcctgt aagctacttg tgtaattccg tactcaaaaa 2419561 accagttatc aatgacattg tatacgcctc ggttgacgcc atataggtta ttacatttct 2419621 tgtaaaagca gagatccgga agatttaact cctgatggga aagaaggctt tcttttttgt 2419681 ttggtgccat aatcccaatc agctcaaagc gttttgcaac gcacgaaata tcctttttaa 2419741 tttgctttgt taaagactcc aaagaatcaa accttctttc ttctctaatt ttaaagagaa 2419801 tgctgcattc gattttttct ccataaatgt ctctatgaaa gtcaaacaaa aaaatctcca 2419861 atgtcttttc aaggttagag cccaccgtcg gtttcacacc gatattcata acccctaaat 2419921 gaaattgatg attgactgtc gccagaaccc cataaactcc attacgcagc ccatgtattt 2419981 ttgcatctac atttgccgtg gggaatccaa gctttctgcc taattgtttt cctttcacaa 2420041 ccgtaccggc aatgatcgtc aaaaaagtca gcctcctctc tcagcttccg cattcgatca 2420101 gacgaaacct aatgatgtga tgaatgtaaa acggattgat gctgcggaat gccaagaccg 2420161 agattttccc gcaatgtccc gccgcgataa tcttgacgat aaagccctct ttcttgaaga 2420221 atcggaatca ccttttctac aaaagcatca agtgttcccg gtatatccga cccaacgata 2420281 aacccatccg ccgcctcagc gttgaaccaa gtttcaatta aggatgcgac acgctctggt 2420341 gttccgatga atagagtccg tggaaaagcc atttcctgtg ctacctcccg caatgtcaga 2420401 tttctggctt ttgcttctct cttaatccgg tctgttgtgc tttgaaacgc attctttccc 2420461 acatcgccaa tatcgggaaa tggctcatcc aacgggtaaa cactcagatc ataatcatca 2420521 aaaaaacggg ccaaataagt aacagcattt tcaatcggta tcaattctgc aaattcacga 2420581 tacttctttt ccgcctcttc ttccgtatct gccacaatcg ggctgatccc tggaaaaatc 2420641 cgcacacttg aaggatcacg cccttcatca gcagctcggc ttttcacatc cgcataaaac 2420701 gcttttgtct cttctaatga attggaatgg gtaaaaatcg catccgcatt tttagcagca 2420761 aactgccggc ctgtttctga tgaacccgct tgaaacacta caggctctcc ctgcttagag 2420821 cgcccgatat tcaagggccc ctctacttga aaatactttc ctttatgatt caggcgatga 2420881 agcttcgcct gatcgaaaaa ctgccctgtt ttcttattgt gtataaatgc gtcatgctcc 2420941 caggaattcc acagcccgcg cacaacatcc aaatgctctt gtgcgatctc gtaacgttca 2421001 gtgtgttctg gcaaattaga cttactatgg ttgcgcgccg ctccttcctg cggcgaagta 2421061 accagattcc agccggccct gcccccgctg atatggtcca gcgacatcaa ttgtctggag 2421121 atagtgaatg gctcagtaaa agatgtagag aacgtcccta ctaaaccaat atttttggta 2421181 accgatgcca gcgcagataa aatggtgatc ggttcaaaac ggtttaaaaa atgaggaatc 2421241 gatttttcag aaataaataa gccgtctgca atgaaaataa aactaaacaa acctttttca 2421301 gctgtttgcg cctttttcat gtaaaattca atattcgtgc tggccgaggg atcaacatcg 2421361 ggatgacgcc agccgtcagt tgttcccccg acaccgtgaa tcatggctcc aaactgaata 2421421 aaatctgcac gtgtcatctt tttgcctcct ttatctgtgc atgattagca agtgcaagat 2421481 caaggtgttc aatgccgatt tcagttatcc cttgatactg attgccgcgc ccgatttcga 2421541 ccacaggcac atggcgcacc ccatatttca cctgtaaaat atcccgaagc ttttctttct 2421601 ctgaaacatc gatattttgg aacgggaacc ctttttcatt caaataattc ttgacttcct 2421661 cacaatacga acagcctttt ttactccaaa ccacaatgtt cacaacatca ctcattcttc 2421721 tgtccctcct taacgttttg cagctaaaac tgcatcgctc agcagctgat aagacagctg 2421781 tttttctaca gcatttttga tcggtgtaaa aataacaaaa tcattgattt tgtatgtgcc 2421841 tgataaacgt gttaattctt ctgccacttc ttcctttgtt ccggcaataa tcccggtttt 2421901 ttgcacgatg atgtcatagg gctctgtgac gttttccaga taggcctcag cctgttcgcg 2421961 ggaaccgacg ttgaccttac gcccgtcttt caaaaccact tttatcgatt cacgcgacac 2422021 aatatgtttt tccgcttctt cttttgtatg tgccgcaaaa acagcggggg caagatgaaa 2422081 ttcagcctca gatcctggcg ggagatgcgc gtcaaatgct cggcgggctt ccttcagcac 2422141 ttcctcttca ccgttaataa agtaagcaaa gacaaaagag attcccagtt ttgcagcaga 2422201 aatggcactc tctgtgcttc ctcccaatag aaaaataccc ggcttccgat caacctgcgg 2422261 cctaggacgc aatgcggcat agcggtgggt atcaggaaaa tcatcccgaa cgaaatgagt 2422321 aagctcctcc agtttttcat caaactgacg caccggtttt ttatattcgg cctgcagcgc 2422381 gtctgtggac agctgaaacc cgccgggcgc tttgcccact ccaagatcta tacggccggg 2422441 agctaacgct gatagaagat ggaattgctc cgctacttta taagagctgt aatgctgcag 2422501 catcactccg cctgatgcta aacgaatttt tcttgtgctt gcagcaagat agcctaaaag 2422561 aacctcgggt gcagaccctg caatctcatc attgttgtga tgttcggcca cccaaaatcg 2422621 gtgatatcca cattcttcag ccatttgtgc caatttcact gtatgctgta atgtatcagc 2422681 tgctgtctcc ccttcaccaa tcaagctttg gtctaaaata cttaagcgga tcatatcacc 2422741 ggctccttta tgtgttcttt tggttcaaat aaatattccg gcgaaacacg gcggagaaac 2422801 tgcctcgttc tgtctttttt ggtatggcgg aagacttcct ccggggttcc ttgttcaaca 2422861 atgactcctt catccataaa aacaacttga tcagagaccc ttcttgcaaa ctccatttca 2422921 tgtgtaacaa caatcatggt ggctccggtt ttcacgattt ccagcattac ctcaagcact 2422981 tcaccgacca gctccgggtc aagcgctgcc gtcggctcat cgaacagcag cacatcagga 2423041 tgaatggcaa gcgcccttgc tatccctacc ctctgctttt gtcctcccga taactgactc 2423101 ggataagcgt tcaatttatc ttgaagcccg acctttctca gttcattttc cgctacggca 2423161 tacgcgtctt gttttctcat tttccgggca atcgtcaagc cctccatgac attttcaatc 2423221 accgttttgt gagcaaacag gtggtattgc tgaaatacca ttgccgtctg ttttctgagc 2423281 cagtgaacct cttttttgga cggaaagcgg caattaatca ctttgtcatg tatagaaatg 2423341 atcccttcgt ctggacgttc taataaattc aggcaccgta aaaaggtggt tttccctgat 2423401 ccgctcggcc cgataatcgt cacaacttct cccttgcgta ccgtgagatt tatccctttt 2423461 aatacatggt ggatgccaaa ctgtttatgg atatttttaa tctcaatcat aaagtgcctc 2423521 cttgaaatct ggctgccttt ctctctaata ctccatttgc ggattctagg attagagtca 2423581 gcacccaata gataatcgct gctccgataa acgcttctaa aaatgcataa ttatcagaag 2423641 caacgatagt cgccgtccct gtaatctctg ggacagccac tatagccgcg atagaggtgg 2423701 tatgcaaaaa gccgataccc aaatttgtga agtttgggat ggaaaccttc agcgcctgcg 2423761 gcaatattac acgccgaaag gtttggctgt atgtcaagcc gattgaataa gccgcttcga 2423821 cctgtccggt atccatcgcc agaatgcccg accggatgat ttctgtgaga taagctccgg 2423881 cagttaaaga caaggccatg atgacaaaca tggagaccgg tatctcatta gcggaccagc 2423941 cgagatgaaa aaaactgctg acttgatctg caacaggcgg tatccctaaa taaatcaaca 2424001 taatgtgaag aattgcaggt gtacttcgaa agaaagacac ataaaacctt gagcaagcca 2424061 ccaagccctt aattctaaaa attctaacaa ttatatttcc aagagccacg agaaatccaa 2424121 acacaatcgg caaaacagcc atcatcaatg tcagaggaat ggtctttacc atttctttca 2424181 tggcggaaac gataaatgga aagtcaaatt gcaatcttct cccccctcat ccgaagaaat 2424241 atatcaatgt atgttcatgt caaaaacagt aacaatcctt gtttgattct tcttgattcg 2424301 tttttctgcc actcgaaaga accattcgaa taaaaccgct acagcataat aaacaatcga 2424361 tagcgcaatg taaacttcaa gagaatggtt gcttgaggta atcagtgttt ggccccttcc 2424421 ggacatatcc ataacaccta ttgaaaaggc tagagacgta tcttttaaag aactgatcac 2424481 catgtttccc atattcggaa acgcctggac aagtgcctgg ggcagaacga ttcgcctgaa 2424541 ggcctgacta ccgcttaagc caatactgta cgccgcttcc gtttggcctt tatctacact 2424601 gcccaccccc gctcgaatga tttctgcggc tgccgctgca ttgcttaacg cgtaggttgc 2424661 gacagcagca taaaacgggt ccatttttga tgtatcaatc ccgataagcc ccgtaagcgc 2424721 cgggatcccg taaaacacga tgaaaagctg caccatgata ggcgttcccc tgaaaaacga 2424781 gatatacact tttgccaatt gatttacaat tggaatatta tagatgcggg gcagtgccag 2424841 aaagagtcct aatacaaaac cgaaaagcaa ggacagtgtt aaaatgtata atgtaaccgg 2424901 taaataagcg gttaacgtcg gcacaaaatc tccaatcatg ttcatatcaa acgctttttc 2424961 catcactgct ccctctcttt ttacctaata ctgctctttg gaatagtcgt caccaagcca 2425021 tttcaaactg agccttttca acgttccgtc atcaatgatt tcctgtaagg ctttatcaat 2425081 atcgtcactt aacgtttgtt catttttgtt aaacataaaa tacactttgg catttgaaag 2425141 cacattaccg acggtttttt ctttaatagt gctcgtcttg ttttgaaagt ctactgcaaa 2425201 aggcgttgag atcgttgcgt ccgcacgccc cgatttcagc tgattcgcag tctcatttgc 2425261 gccttggccc tcataggcaa tctcaaacgg ccgtccatta tcctcattcc attttttcag 2425321 tacaagcgct ccgttggagg ttgcactcgt aatcacccgt tttcctttta agtcttcaat 2425381 tccacggatc gtatcgttat tttgaagcac agtaattttt aaaggaaaat ggttgtaagc 2425441 aaccttgtta aacagaaatt ttttctcacg ctctttgctt ttctccattt gatgtgccac 2425501 gatatcgact ttatgctgtc cgaggctgac aagcaggttg gaaaattcca tcgttttaaa 2425561 tgtgaattta taatgtggca ggcgcttatc aagctctttg atcagttcga catcataacc 2425621 ggttaaatcg cctttttcat cgataaagca aatattcgga aattgggttc cagttccgac 2425681 cgtgatcgtc tgtaccttct tttgcccggc tcccgtcgtt tgactgcctg caccgcaagc 2425741 tgacagaact gttataagcg aaaataatat tgccatgaat gctgttttcg ttttcatctc 2425801 atcgccccat ttatttttca aaacttgatt ttgaataatc tgccccgagc cattttcggc 2425861 ttagtttttt tagcgttccg tttttctcca gctttttaat cgcttgatcc gtgtcatccg 2425921 ccaaggtttg gctgccttta ttaaacataa agtacacctc ggtatctaat aacacgtcac 2425981 cgactgtctt ttggcggaag gcgtgcgttt tattctgaaa atcgacggca aacggtgtag 2426041 ctatcgttgc atctgcgcgc ccggtttcaa tttgattggc ggtatcattg cttccctgtc 2426101 ccgcatattt caaatgaatt gggctgccgt gcgttttgtt gtactttgta atataatctg 2426161 ccgcatttga cgtggcgcca actatgactg tttttccgtg taagtctttt aatgtatgaa 2426221 tcttgtgatt atcctctttc accgtgatgt acatcggcga gtagttatat gggactttat 2426281 gatacaaaaa acgcttttct cgttctttat ttttggccat attgtgcgca atcacatcaa 2426341 tttttttatt tccgagactc gtcagcaaat ttgagaaatc catcgtttta aattcaaatg 2426401 tatattgagg caactcctta tcgatggctt tcatcacttc aatgtcatac ccggtcaatt 2426461 cacctttttc atttaaaaac gcaatattcg gaaaatctgt tccagtgccg actatgaccg 2426521 tttgagcctg acgatctgtt ttgttatttg tttgcgaaca tcccccgcca agtaatgcaa 2426581 acactgacag cagcaaaacc aatcctttac gcttattcat aggctgcctc acatcatgcc 2426641 cagctgggcg cacctaaaag cgttgggtta aatcgttccg gaatcagaac cttgtgcatc 2426701 atcacaccta tgtccccgtc tttttcctgc tcaaaataca cttcataccc tctccttctg 2426761 tacatgtcag caagccaagg atgcttgcgc gccgatgtgc cgagtgtcag cgcaggagcc 2426821 ttcagcatat ctcgaagcac tttttcttca acatacgtaa gcagcttact tccggcgcct 2426881 tgccctttat attccggcag tgtcgcaaac caccacacaa atggatattt tgaaggaggc 2426941 gtctcactct cccacgggaa cctgattgta atcgttgaaa tcagcttccc atcccgctcc 2427001 agcacaatcg ctgaatgatg ttcaatattt tctgatacca tttggatatc agctctcgtg 2427061 gatggccaat caatatccag ctgccgaatg ggctgaaatg cgctgttaac cagtttcaac 2427121 agctccgatg catcttcaac agttgccagt cgaaaaatat catcactcat ttttgtcact 2427181 cctcttcaca aaatatataa ttcctatttg tttactaagc ttttattgtt tatactataa 2427241 agcatactct gatctttgac taatcaaaaa aagtaaacct tcacttcagt aattttaatg 2427301 atgaaaaaca ggagggagca cattggagtt acgctcaatc aaaacgtttc atacgattgt 2427361 aaaatttgga agcttctata aagctgcaga aatactcaac tactcgcagc cgacgatatc 2427421 gatgcgtatg aagcaattgg agcaggattt aggcgtactg ctgtttgaaa gaggaaaaag 2427481 cctgcagttg acaaaagcag ggaagctttt ttatgaacga acaggagatc ttttgatgca 2427541 atacgaggcg cttaaacaca acctctccga cttaaaggaa gaagaggcag gcattatcaa 2427601 cataggggtt tcagagccaa ccgccagtct gatattcccc gagattttaa aggatttctt 2427661 aatggattac ccaaagataa cggttaatat caaggttgat gacgccaata cctgcagtca 2427721 aaagctctta gacgggacga ttgattttgc agtctgcggc gagccggagc tgattcttga 2427781 aaattactac catccatttt tttatgacac attaaatgtg attgtatctg atcaacatcc 2427841 gctcgctgag aagaaggctg tccatttgtc tgatttagca gaagagcgct tcatatttac 2427901 gcccgccaat tgccccattc gcttacaaat tgaacagcat ttacatagag aactcgggaa 2427961 tcgctacaaa aaaatggagc tcacaagcag catgtcacat gaatattacg tacgtgaaaa 2428021 catcggaatt tcaatcttta ccagcaccgc acattctaaa ccgttcaacg gcactaaagt 2428081 cattccaatt ctgaacctgg atatcacccc gcccataggg ctgttgacaa atcaaaaaga 2428141 agttcatttt gaccgcgcca cgaaggactt gatcgcccgg ataaccaaac gttttcagca 2428201 gcgcagcaaa gaattggaag gaacctctga taagaccatt acaggataac tgaaaaaata 2428261 aaaaccacct cctgattcat caggagatgg tttcacggtt taaagctcga tcgtctcacc 2428321 gaccgacatg actttgccga ctccgcccgg caggctgtca gcgaatgctt ctgggtcttg 2428381 ttcgatgacc gggaatgtat tgtaatgcac cggcacgacc tgttttgcgc gcagccattc 2428441 agcagcaagc ttggcgtctt caggccccat tgtaaagtta tcgccaatcg gaaggaaagc 2428501 aaggtcgata tgattcaatt cgccaatgag tttcatatca gagaaaagtg ccgtatcgcc 2428561 cgcgtggaaa atcgttttat cttctacagt cagcaaaata ccggcaggca tgcctgtgta 2428621 agtgatcgtt ttgttttctt catctgtgat ggctgatcca tgaaaggcct gtgtgagctt 2428681 cacttttcca aaatcgaact ggcgggagcc gccaatatgc attggatgaa cattcaagcc 2428741 tttccagcct aagtacacag cgagctcgtt cggggctata accagcgcgt tattttgctt 2428801 ggcgatttgt tcagtatcac cgacatggtc attgtggccg tgcgttagta agatgacatc 2428861 cgcttttaca tcctccggct ttatatccgt taatgaattc cctgttaaaa acggatcaaa 2428921 aataatatga tggtccttcg tttccactgt gattacagaa tgtccgtgat atgtcacttt 2428981 catttctttc acctcgtcac atgattttgt tttttttatt ttcccttttt aaaaagctga 2429041 aaaacttatg ttgtttgatt cttgttaatg acattgaggc ctccggtggc ttcaatgaca 2429101 gtccctgtca caaggtctga gttctcctca cacaagaaag cgataatcct ggcaatatcc 2429161 tcgcctgtac cggatcttcc tatcggcgtt ttttctttgc cgattcgcat tctggcttcc 2429221 tctatcgatg cttctttcat gtcgccgaca atgtctcctg ggcaaaccat gttggcggtt 2429281 atgccgaatt cggcttcttc aatggcaatt gtcttcgtca aagaagccaa gcccactttc 2429341 gcagcgccaa atgccgatcg gtgaagccag ccgggcgcgt gagccgcacc ttggaatccg 2429401 tacgtaataa tgcgtccaaa ttgctgtttt ctcataatag gaataaccgc tttgaataaa 2429461 tgaaagacgg cgcttaaatt tccttccagc atgccatacc attcatcatc agtataatcg 2429521 gctaactttt tacgttcaaa tatgtatggt ccagcgttgt taatcaaaaa gtcgatcctt 2429581 ccgaagcggt ttaaggcagc ctctgcaata cgcagcagat cttctttttt ggtgacatca 2429641 ccttttacaa attgcagccg gtcaagacaa tcgggacagg cttccttcag gcggctgact 2429701 gcctcctcat cctgtctgta attgactgtt actgaatacc cctttgcaag caacgtttca 2429761 gtcactttgc ggcctaaacc cttcgaaccg gcagtaatta aagcatgtcg cacatgaata 2429821 cctcccaaag caacgtcgcc gctttcaata aagtgtttct tcttctactt tactataaaa 2429881 ggcttgcaat atcacttttt acactttggc atacaaaaaa agctgcctgt acagacagct 2429941 tattctgcag gagatgaaga ctcctgatca ggcatatcga cataaccgct ttgatatgct 2430001 tctgaaatga gccttgttgt ctcctggctt tcttgttcat cataaatata gcgttccggt 2430061 tcttttttca tcattctgcc tcccatcatt atagaggtag gttggctata atgacgggat 2430121 tttatgaagg aaattttaac aaactcctgc tgccacgcaa gctttcgctt tttcaagcgc 2430181 ctgttccacc tgtttgaatc cggtgccccc ggcgctcatt cttttttcaa ctgcgtagta 2430241 agggtctaac acagtgtaaa tatcttcttc aaatagtgtg ctcgcctgct gaaactcgcc 2430301 aaacggcata tcgcttaaat agatccctct ttcgatgcat gtgtacacaa gtttcccgac 2430361 cacttcatgc gcttctctga acggcattcc ttttttagct aaataatcgg ccagttccgt 2430421 cgcgtttgaa aagtcttgtt ttgttgcttg cttcatgacg tctttgttta cagtcattgt 2430481 ttggatcatg cctgtgaaga tttgcaggct gccctccacc gttttcaccg tgtcaaacat 2430541 gccctctttg tcttcctgca gatctttgtt gtaagcgagc ggaagtcctt tcatgatcgt 2430601 aaacagcccc atcatatcgc cgtatacgcg tcctgttttg ccgcggatca gctccgccat 2430661 atcagggttt ttcttttgcg gcatcatgct gcttcctgtt gcgtacgtat cgtcaagctc 2430721 gatgaattta aactcctgcg agcaccataa aatgatttct tcagagaaac gggataggtg 2430781 catcatcagc atactgctgt tgcttaaaaa ctccaaaatg aagtctctgt cgctgacgcc 2430841 gtccaagctg ttttcataaa tggcatcaaa gccgagcagt tccgctgaat aatcacggtc 2430901 aattgggaag gttgttcccg cgagcgcccc gcagccgagc ggagatttgt taatccgctt 2430961 cattgaatcc tgaaaacgct ccttgtcgcg ctcaagcatc cagaaatacg caagcagatg 2431021 gtgagcgaat gaaatcggct gggcgcgctg caaatgtgtg tagcccggca gaatcgtttc 2431081 aacgttcgct tccgcctttt caatcagcgc actttggaat gcctcaatca gctcgatgat 2431141 gtggccgaca tgattcttca agtataaatg catgtcagtc gccacctggt cattccggct 2431201 tctgccggta tgcagcttgc cgccaagagg accgatttcg tcaatgagca ttttctcaat 2431261 gttcaaatga atatcctcat aatcgactga gaattccaat gctccctcct ctgctttttg 2431321 caaaagggta ttcaggccct ctcggatttt caactcttct tctgctgtca gaataccgca 2431381 ttttttcagc atggcagcat gtgcgagaga ccctgtaatg tcttcagcaa ctaaattttg 2431441 gtcaaatgat atggacgcgc cgaactcgtc gacccatttt tccggtgttt tttgaaatcg 2431501 gcctccccaa agcttcttca tgctttaatc tgctccttct ttttcacgat gctgttcact 2431561 tttgtcggaa gtccccaaag ctcgataaat ccgattgctg catggtgatc aaatgcatcg 2431621 tcttttgtat atgttgcaag tttttcatca tatagagagt attccgattt acgtccttct 2431681 acaattgcat ggcctttaaa cagcttcacg cggacaatgc ctgtgacatg cttttgcgtt 2431741 tcttttaaga aagcgtgcag cgcgtctttt aacggtgaga accataagcc gttgtaaatg 2431801 atttctgaca ttttttgctc gatgatcggt ttaaagtggg ctacctcttt caccagtgtc 2431861 aaatcttcta attctttatg cgctttgatc agtgtcatcg caccagggca ttcgtatact 2431921 tcccgggatt taatgccgac gaggcggttt tccacgtggt cgatacgtcc gacaccgtgc 2431981 gcgcccgcca tttcattcag cttcaagatc agctcagaaa gcgagtagga aacaccgtca 2432041 atggagacag gcacgccctg ttcaaatgca atttcaatca cttccggcgt gtccggcgtt 2432101 ttttccagcg gagctgttaa atcgtatgca ccttctggcg gcgccgccca tggatcttct 2432161 aaaatgccgc actcattggc gcgtccccag aggttttggt cgatagaata cgggctgtca 2432221 agattgatcg gaatcggaat gccgcggcta gccgcatatt caatttcttc ttcacgtgac 2432281 cactgccatt cgcgaaccgg cgcgatgact tctaggtcag ggtttaatga tttaatggag 2432341 acttcgaaac gaacctggtc atttcctttc cctgtgcatc cgtgggcaat cgcctgtgca 2432401 tcttcttttt ccgcaatttc aaccagtttt ttcgcgatca gcggtcgaga taatgccgaa 2432461 acaagcgggt attttccttc atacattgtg tgggcctgca aagagataag cgcgtaatcc 2432521 tgtgcaaatt cttcttttgc atcgatcacg taggagtttg tcgcgccgac ttcaagcgct 2432581 ttctgctgaa caaatgccaa atctttgccc tcaccgacat ccaggcagca ggcgattaca 2432641 ttatatcctt gctcctgaag ccattttatt gcgacggaag tatcaagacc tcctgagtat 2432701 gctaatacga cttttttctg ttctgacatg ataaaaatcc cctctcaacc gtgtttctat 2432761 tttgtataaa aataaattat atttaataaa aatacatttt gtatgtatac actttaacaa 2432821 gtacgtttcg ttttttcaag ccttttataa aaaaaacttc acctaaattt caggtgaagt 2432881 ttcatagtat ttattcattt acttgtcttt tctgatttct ctgaccacat gcgcaagttc 2432941 gggaataatc agcttattca ttgccagctt tactgcgccg cttgagcctg gcgttgagaa 2433001 aacagcggta tgctgaatga cgccggcagt tgctctcgac atgattgcgg cagagccgat 2433061 atcctctgta taactcagca tcctgaatat ttctccaaag ccgggcagtt ctttcgaaaa 2433121 cagcggcgtt atggcttcaa ttgtgacatc ccgatctgct atgcctgtcc ctccgtttaa 2433181 gagtaccgcg tctgtctgtt catccatgca gcccgcaagc actgaccgtt gcaaagcatc 2433241 cttttcgtct tttacaattt catatgcggc aatatgatga ccggcttctt ctaaaaatga 2433301 gatcatcagc ttgccgcttt tatcggtttc atctgtcctc gtgtcactga cagtaatcac 2433361 tttgcaccga acgatatcgg gagcttcttg tttatgctct tgaacgctca ttggcccacc 2433421 tcttttatgt tttctgtctg tcactatcat gcatcaacaa aaaagcacat tcaagagaat 2433481 gtgctttcat gcgatttatt ttgctaaacg aacaacgtcg cgcgcaatca tgacttcttc 2433541 atcagtcggg atgatcatga cttttactgg agaatgcgga tagctgatga aagcttcctc 2433601 gccgcgcacg ttattaagcg cagggtccca gtatacgccc atgaattcta aaccgcgaag 2433661 aacgcgttct ctgacttcca cactgttttc accgataccg gcagtaaaga tgatcgcatc 2433721 tacaccgctc attcttgcag cgtaagaacc gatgtatttg tggattctgc ttgcgaatac 2433781 ttcaagagcc gtttccgcgc gctcatttcc ttctttcgta gcttcaacga tgtcacgaag 2433841 atcgcttgag aaaccggaaa tgccgagcag tccgcttttt ttgtttaatg tattcagtac 2433901 ttcgtcagcc gtttggcctg ttttctccat gatgtatggg atcagggcag ggtcgatgtt 2433961 tccagagcgt gtgcccattg ctacaccggc aagcggcgta aagcccatgg atgtgtcaat 2434021 agattttccg ccttcaacag cggcaatact tgctccgttt ccaaggtggc aggaaatcag 2434081 gcgcaagtct tttaacggac ggccgagaag ctctgccgca cgctcagtta catatttatg 2434141 tgaagtgccg tggaagccgt atttacggat gccgaatttt tcatagtatt catacggcaa 2434201 gctgtaaagg taagactgct caggcattgt ttggtggaat gctgtatcaa atacagctac 2434261 cgcaggaaca tttggaagca cttctttgaa cgctttaatt ccaacgatat ttgccggatt 2434321 gtgaagcggt gccaattcag aaatatcttc gatttcctta atggtttcat ccgttaataa 2434381 aacagaatcg ctgaattttt ctccgccgtg aacgacacga tggccaattc cgtcaatttc 2434441 attcaagtct ttaataatgc cgaattccgt taacttattc agcagcattt taacagctac 2434501 cgcatgatct ggaatatcag ttacttctgt atttttttcg ccgttcacag aaattgtgaa 2434561 tacgctgtcg gcgataccga ttcgttcaac taaacccttc gttaaaacgg tttctgaagg 2434621 catttcgaaa agctgaaatt tcaaagacga gcttcctgcg ttaattgcaa taattttgga 2434681 catgattgac gctcctttat actctgtatc aacaacttcg tttttcgtac ttttttcccg 2434741 gtgaatatca acatcttctc cgaaaaatat ctgacttttc catttaaaca ttgtcatgtc 2434801 ggcttttcaa gtcaacttgc gtattgataa cgcttacaat aagaagtcgt tattttcaga 2434861 cacattcact ataggttttg tattgatgaa cgcttacaat ttgcggtttt tccctctgta 2434921 ttttgtgttt caaagctgga ttcaattcgt caagtccggt cttcaaaagc ataaataaaa 2434981 gcagcttagg catcgacctc atacggctgt ctaagctgct tttaaaacac ttacttttct 2435041 tttttaaacc attcatcaaa ttgagccatc atatcaagca tcgccttttg attggagaaa 2435101 gacggaagat tcgcaagcag aatttgcccc ggcgctttcg tattctctcc ttgtttctga 2435161 agcacaagga tgcttttggc atgagcttcg tctttaaaaa tagattttgg cagctgcaac 2435221 agtgcgttga tatgaacctt atctttgaaa aactgtttca gcttgccgct ttgggagctc 2435281 tcaaacaaat gattcggaat cataaaaaat aagtagccgc ccggtttggt atgcttgacg 2435341 ctctgttcaa taaacagatg atgagcgaag gaatggcctt cgtcagcttt gagctcaaac 2435401 gcttctgctc cttcgtcatt cggataatag ccgactggca gatcacaaat gaccgtgtca 2435461 actggatcga taaacaacgg ctcaaggctg tcctggtgga aaagctcaag ctcttttttc 2435521 agaaggttcg cttgggcata ggcgatcttc aagagcacat catcaatttc aatgccaaag 2435581 ctgtttgccg ttttttcaga cagctggttc agcacggtaa acagaaggtt cccagttccc 2435641 agggctggat caagaatggt cagttccttt ttgtccgcca taaatttatt caccaaatag 2435701 ctgatgaaaa gcccgatcgt atccggcgtc atttgtctgt ttggatgcga gatatctttc 2435761 attcctttaa ggacggcaag ctgaaaagcc ttgcgtaccc actcatgctc atacgtgccg 2435821 aattccgctt tttcaagcag agcctgaagt tgtttggttt tctgatcagc aggcagtttc 2435881 agctgatccg ttttttcaag aaaatacatt tctcctgctt cggccagcgc ctctatatat 2435941 gaaatctgca attcattctt tatcataatc gcggcttcgt ttaacagctc atacaccgca 2436001 cctacatggt ctttttgcat attgtgttcc tccttgccat gaaaaaagct ccggcggcag 2436061 cctggagctt ttttccctgc ttactttact aatgccttag cagcctcaat tggcttttca 2436121 tagttcgggt ggtttgttgc ttcgcttaca tattcagcgt aaacgacttt tccgttctca 2436181 tcaaggacaa atacggaacg cgcaagcaga cgaagttctt taatatacac accgaacgct 2436241 tcgccaaatg acatatctct gtggtcagac agtgtttcca ctttgtcaat tccgttagcg 2436301 ccgcaccagc gcgcttgcgc gaatggaagg tctgcactga ttgtgtagac gttgacatct 2436361 ccaagctttg cagcttcttc gttaaaacgg cgtgtttgtg catcacaaac acctgtatca 2436421 attgaaggga taacagaaat aatcgttacc tttcctttca tgtcagctaa cgatttttct 2436481 tcaaggctgt tagtcagcac tgtgaaatca ggagcttgat ctcctacctt cacttcttgt 2436541 ccgacaagtg taaccggacc gcctttgaat gtaatttcag ccattataat tcctcccttt 2436601 tgtatgtatg tctctatcat agtaaagttt cctgcaaact gcaaagttta tgccaaaaaa 2436661 aagttaactg cggccagcgc agttaacctt tttttaataa ttcatattgt tcatttggtt 2436721 ttgattttgg ccttggcttt ggtttttgtt atttttcttg aacatttgct ggatgcgctc 2436781 gagtgtttga ggggctgcgt ctaaaatttt ctctattaaa tgggtatttt catctaaatg 2436841 aagcattctg atgcctgtcg atccgacaat taaaaacgcg atcggcgtaa tggacacacc 2436901 gcccccgctt ccgcctccga aaggaagttt ctgttctctt gtctcatcgt cttccgattt 2436961 cttttcggcc ggctttccgc caaactcgct tccgcctgcg gcgaatccga atccaacttt 2437021 agaaacagtt aaaatcacac ttccatcagg cgtttccact ggatctccga tgatggtgtt 2437081 aacatcaatc atttccttca agttttccat tgcggttttc attaaacctt ggatgggatg 2437141 gtctgccata tacgcttcct ccttaaactg atgaatcatt ctttgaagtc attctagccg 2437201 acggattctt ctttaatacg gatagctccc gtccgtattt gacgaatttg aaagctgcaa 2437261 gcatagcatg tccaaagcga aaaaagaata tacactgaaa atgggtcttg gaaacaggga 2437321 cttgaaacga cgggatcacc tcatagacag gtttattcac aaagtccagg tggtcgtaga 2437381 gcattgctgc gataccgccc ttcacgcccc atacagcacc ggttaacaca cctgtcactg 2437441 ccgcgtcctg aattccgatt actgtaaccc attctagttt tgtgatatgt aaatgcgcga 2437501 gaaaagacgc gctgattttc cgcagtctgg tgacctgatg caaaagcatt tcgattttat 2437561 taatgctttg ctgcacatcg ttttgtgtaa tttttttctt tccgctgctt tttttcattt 2437621 tggattcagt tttttgtttg atatccactg ttccgtcttc tttgttcacc ttaatcgccg 2437681 ggattgtttt tttgatcctt ataaggccaa acagcgccgt aatcttcaag gtcaatttgt 2437741 cattatcatc ggcatgaaga tactccagcg cgacatggat tttcattctg agaagcagta 2437801 cgatccctat gagaataaga atggctgtca gtacatacac catattcttc acttcctcta 2437861 ggagcattat cgccaattcc taaaaaaata aacccggacg gaagtccggg ttatcggtta 2437921 tttgcggtat aatttttcat gcaccacggt ggtatccgcg atgtaatcat gaatcccttg 2437981 ttttgtaggt gaaaaggcaa caacgatata taaaatccaa atcttatcaa tataccgtcc 2438041 aaccacttca cgaaaaatca ctgtactcca tgtcagcttg ctatcttgct tcacagaaac 2438101 cactttgagg ccgaacacca ttttaccaag cgtctgcctg aagtattttg tcatgagtgc 2438161 gaaataggca agatacacaa taagcgttgt cacactgtag gccgagaagg taaacatgcc 2438221 ggatgttttc ggcagatcca atacggtaaa gaggggagaa acgagcaaat ggtttaatcc 2438281 ccatatcacg agccaatcaa gcaggaaagc ccagaaacga acccaaaagc cagcataggc 2438341 atgtgtcagc agctccgctt cttgcgggcc tttgatgtca ttgcgctcta actcttcata 2438401 tgtcgcgtcc attattgttc cctcctactt cgcatagaga tacatcattc tcggcgaacc 2438461 ggattgcgat agaatttctc tcatattcaa aaaatcaatt tcacttttaa acattttgtt 2438521 cgcgcccatg gaaaacagtg agcctaatcc gaagctttcc tcataagaaa tgacagaggc 2438581 gtttttcaaa tccttgtgat cctttttcat ggccgtaatg gtatcgtcat aaaaaccaag 2438641 ctcatcaacg aggttcagtt ttttcgcctg ccgtccgtca tacacgcggc cgtccgcaat 2438701 tttctttacc tctgctttcg gcatgccgcg cccttttgaa atgacatcaa caaagccttc 2438761 atacgaatta tcaaccatcg attgcatgat gtttttttct tctttcgtca tctcacggga 2438821 aggagacata atgtccttat gggccccgct cttaatcgtt tcaaaagaaa tgccaagctt 2438881 gtcggcaagc tttgaataat tgacgctttc cataatgacg ccgagtgacc cggtcagggt 2438941 ttccggtgtc gcaaaaatct tatcagccgc tgttgagatg taatagcctc ctgatgctgc 2439001 catcgaaccc attgacacgt aaatcggttt tttcgtttct ttcttgattt cttccagttt 2439061 cttatgtatt tcagcacttt catacactcc gccacccgga gaattcacct tcagaacgat 2439121 acctttgacc gtcttgtcat cttttgcgcg ctcaaggttt tttaagaacg ttctgtggtt 2439181 atatccgtct gcaccaagca gactgcttga gtccccatta tcctgaatgg tgccgctgac 2439241 ctctaatacg gcaattttac ttgagggact gccgttttcc agcgtcttct cctgcgattc 2439301 atccgtcagt gatgtgagat ccgtttgagc gcctttgacg ctttcaaaga aactcataga 2439361 gatgctgacg ataatagaca cgccgaaaat ccccagagca atcactaatg caatccatct 2439421 ttttgcattc attttttctc ctcctttttc ctaaactctc tcattatacg attcaatatg 2439481 aaaaatgttt cacttcatga gaaagctccg gcttaacggg ctgccggcaa acgtggtaca 2439541 cttatggcca aaggtatttt atcacaaata ctggatggca gaaaaactta aatatgacag 2439601 caaaggggaa atgggatatg accgatcaac gccgtaatgt ttattttttt cacaaacagg 2439661 atcaggaaac gaacgaacaa gcccgctcgt taacacaatt agcggaagag catggattta 2439721 ccgttgtgaa ccagcactca gacgccaata ttatcgctag cattggcggg gacggcacat 2439781 ttttgcaggc agtcagaaag acgaattttc gtgacgactg cttgtacgtc ggcattacca 2439841 aaaaggggaa agctcattta tattgcgact ttcatagtga tgagcgagaa aaaatggtcg 2439901 atgcaatgac gtttgaacaa attgaagtga gaaaataccc gctgattgaa gtgacagtgg 2439961 atcaagccag tccttttcac tgcttaaacg aggtatccat ccgctcaagc atcatcaaaa 2440021 cctttgtgat ggacgtgctg attgacgatc tgcactttga aacgtttaga ggtgacggaa 2440081 tgattatctc aacgcctaca gggagcaccg cctataacaa gtctgttgca ggagctgttg 2440141 ttgatccatt gcttccatgc atgcaggtat cagagcttgc atcccttaac aataatacct 2440201 accggacact cggctcgcca tttgtcctca gctctgaccg aaagctgacc cttcgtgtgg 2440261 tgcaggacgg caacgaacac ccaatcatcg gcttggacaa tgaagcactc agcacgagaa 2440321 atgtgaaaac gatcgaaatc aaactgtcta ataagaaaat caaaacagtc aaactaaagg 2440381 acaattcatt ttgggaaaaa gtgaagcgta cttttttata gaaaataaaa ggacaggctg 2440441 ctgcctgtcc ttttatgatt tctcatatac aatctggccg ttaatcacgg tttttttaat 2440501 ctctaaaaga tgaagctgtg cggggtcaat ggcaaacgga tcaccactga gaactgtaaa 2440561 atccgcgtca tagccttccg caatttttcc gcgtgacttc tctttataaa tgataccggc 2440621 gctaccttct gtataaagct ttatcgcttc atatacaggt aaacattcac tttcattata 2440681 gcttggcccg ttttgctcat gactgctttt ccggaggacc gcggactgga tccctagaag 2440741 cgggtcaaca ggctcaatcg gggcgtctga accgcccgcg cataaaatgc ctttagatat 2440801 gagggttttc caggcaaatg cagtcttcat ccggtctttt ccgagacggt caatgaccca 2440861 cggaaagtcg cttgcaacga agtgcggctg aaggtcaagt gcgatcggca tgcgtgctgc 2440921 tctctcgatt aattcgttat caagcacttg agcatgaata agccgatcat gccggccgtt 2440981 tttgggcgga tgcttttcta ttgcgttcag cactttttca aaagcaagat cgccgattgc 2441041 atgaacagca acctccatcc ctttttctct cgctttgcga atgagccggc caagggtttc 2441101 gtcatcgtga acctgaacac catttgttga tggatcatcc tgatatggtt ctttcaataa 2441161 agccgttctc ccgccaagcg ccccgtccgc aaagattttc atagcaccga actccacata 2441221 cgggccggac agcttctcca gctgctccca tcgatcgaca gcttcatgat gaacgagcaa 2441281 atggcagcga aacggatact ttccgccagc ggcagctttc tcataagctt tcatcggcac 2441341 cgaaacatca ccataatagg acaagtcttc cgaatgaccg cccgtcaggc cttttgtcca 2441401 gcaatccttt attgcagccg ttaatgcctc atcaacatag tgctgggaga ctggcgggac 2441461 agccttcaga atcaaatcct gcgccttatc aaacaggagt ccggtcggct cgccatttgc 2441521 atcttttacg atgactccgc cgtcaggatc aggagtattt cttgaaattc ccgctgcttg 2441581 aagagccgca gaattgacag ctattgcatg ccggcatata cgcttgagca agacgggcct 2441641 gtcaggaaac aggcgatcaa gatcatgctt agtcaagtag tcaggtgtct caaactgatt 2441701 ttcattccag ccttctccaa tgagccaatc gtttttagga agctgccgct ctctttcctt 2441761 cgcagcctgt aaaattgaat ctttcgacgt cagtgcggac agatcgagct gaagctgttt 2441821 ctcaccgtgg ccgatcaaat gtagatggct gtcaacaaaa ccggggaaca tcactgctcc 2441881 gttcaggctg atttcttctg tttccggcga cccgtacttt tccttcaaac gttcatagct 2441941 gccggtgcct tttataacac catcctcaac ataaactgcc tcagtccgat cgccttcttc 2442001 gagcatcgta taaatgaaac cgccgtgcca tatcgccttc attcacgttc actctctttc 2442061 tttacgcctt tttattggct ttgagctgtt cttcacgttt tcttaattcc actcgtctga 2442121 tttttgcaga agccgttttc ggcaggcttt ccacaaattc aatttctcta ggatatttgt 2442181 atggagcggt aatcgtcttc acatggtttt gcagcatttt gacaagctca tcactgcgtt 2442241 tttcatgatt ttgcaggaca acatatgcct ttacgatgga gcctctgatt tcatcagggc 2442301 ttgcgacaac agcacattct tttacttctg ggtgcttaac aagcgcgtct tccacctcga 2442361 aaggcccgat cgtatagccg gagctgataa taatatcgtc atttcggctt tcaaaccaga 2442421 agtaaccttc ctcatctttt cttgctctgt ctcccgttag gaaataatcg ccgcgaattt 2442481 gtgttttcat tctttccgga tctttaaaat actctttaaa gagcgcaggc gtactgaggt 2442541 gaacagcgat atcgccaacc tcaccaggtt tgcagatttc accgtcttca tttatgatct 2442601 ccacctgatt tcccggtgtc ggttttccca tgcttcccgg tttaataggc gtatctttca 2442661 aaacaccaac caaaagcgtg ctttctgttt ggccatatcc gtcccgtacc ttaatgccaa 2442721 agtgcttttg gaaaacatca atgacttcac ggttgagcgg ctcacctgcg gaaacagcgc 2442781 tgtgcagggc agaaagatca aagcgtttca agccttcaac cttcgccatt aagcggtatt 2442841 ctgtcggagt gcagcagaaa acattgattt tgtagcgatt taaaagctct agatattttt 2442901 ctgctttgaa tctgccgtgg tacacaaaac cggttgctcc gctgccaagc accgctaaaa 2442961 acggactcca tacccacttt tgccagccag gggcagcagt tgcccagacg atatcctttt 2443021 cagaaatgtc aagccaagcg ccggcagaag tttttaaatg agcaaatgcc catccatgtg 2443081 tatgtacaac acctttcggc tgacctgttg tcccggatgt ataagataag aaagccatat 2443141 catctcttgt tgtgtcagct gttttaaatt ggcttccgtc cgcttcaatt gataagaggt 2443201 ttttccagcc ggcatcattt tcaccaatag acagtgtaat cagtttgtca gccgtactga 2443261 catcccggaa agcgccaata aattcggagt agacgatagc gccttttacc tctgcatgtt 2443321 caatccggta ttcaagatct ttcgcgcgaa gcatttcgga gcacggaatg acaaccattc 2443381 ctgatttcag gatagccaaa taaacagcat aggcttcaag cacccgcgga accattacaa 2443441 tcagcttgtc tcccttttta aatccaagat cagctaaggc cgctccgatt ttatttgttt 2443501 cttccatcag cttttcatac gaccaagatt cttgcttgcc cgactcgtcc tcccaaagaa 2443561 gagcggtttt ttgtccagca gcactgaact tttccatttc attcactaaa ttatattgca 2443621 caggggcaat taaatcttca cgttttaaca cgaacaactc ctcactttct ccacccatta 2443681 tacataaata caggctcttt ccgtaaggat atgcctaaaa gcaacctctg taaacataga 2443741 ttttataggc cgctggtcct tttttatatg taaaaaatga aaaagagtgg ggataccccc 2443801 actcctaagc cattatgtga aattgtaaat tagaattgtc ctccgcccat gttttgttga 2443861 gcaaaagata caagacgttt tgtgatctct cctccaacag aaccgttagc gcgagaagtt 2443921 gtgtctgctc caaggtttac accgaattca gaagcgattt ctaatttcat ttggtcgatc 2443981 gcttgagcag ctcctggtac taaaaggttg ttgctgttac ctgagttatt gttagccatg 2444041 tgtctcacct ccttgtgagt atagaatgtg tcaaaacaca tggcttcatt cagaaaaact 2444101 ttggtaattg tatacaggag ctgaaaattg atttaaaaga gttcagcgaa tttatcgtta 2444161 gcttcttgtt cgctataaag ggtcattgtc tcaatgttat ctaccgcttc ttgaatatac 2444221 ggctcgaaat caacaaagct ttcaaagtgt tcaattttct cttttttagg gcgtgttttc 2444281 gggcttggcg gtgtaaagat cgtgcagcag tcttcaaacg gctgaatact tgtctcatat 2444341 gtgccaattt cccgtgattt ttcgatgatt tctgttttgt ccatggcgat tagcggacgc 2444401 aaaatcggtg ttgacgtcac cgcattaatt gcatacatgc tttcaagcgt ttggctcgct 2444461 acctgaccga ggctttctcc cgtaataatg gcaagcccgt ttctcttttc tctgattctg 2444521 tcggctatct gaagcatgag gcggcgggtt gccgtcattg tgtaattttc aggaatttgt 2444581 ttttggatga gctcttgcgt ttttgtaaat ggaacaatat gaagtgtcat gcttccccca 2444641 aaacgggaca gacatttcgc cagatccatt accttttgct ttgcgcgctc gcttgtgtat 2444701 ggcgggctga agaaatgaac agcttctacc gacaatcccc gtttcatcgc ataaaaaccg 2444761 gccacagggc tgtcaaaacc gccagaaagc atcagcatcg cttttcctgc tgaaccaact 2444821 ggcagcccgc ctgcaccttt ttcatcacga attgtcaaaa atgttgcttc ttccctgatt 2444881 tcgattctga gcgggatgtc tgggttgcga acatcgaccg tcaatccttc tgtatttcgc 2444941 aaaatatggc cgccgatttc agcgttcatc tggtttgtat ctaattcaaa ttgcttatac 2445001 gctctctttg tcgcgacttt aaacgtatca cctggtttat actgatcttt gatagccttt 2445061 agtgcggttg ccttaatatc atcaaggcgg ctgtcacact taattgccag gctgaagctt 2445121 tgaatcccaa acacttgctt taaatgagga aaaagagcct caggatcctc tccatttaat 2445181 gtaatcgtca tacgatccct gttggaaaag tattttaaat tcggatagtc tttcaaaacg 2445241 agtctgatgt tttgttttaa gcgctcaata aagctttttc tgtttttgcc tttggtcgaa 2445301 atttccccaa aacgaattaa tatatgatcg taattcatgt tctacctcat catttccctt 2445361 aattttttga tgccaggacg aagcgcgttc ataaacggtt ctgccacatc gcttgtctgg 2445421 ctgtaattta aactgattct gatgctgctt ccggcaatct gctctccttt gcccatctct 2445481 aagagaacct tgctgggctt atgttctttt gccgagcaag ccgatgttgt ggagacgaat 2445541 atatcctgtt cctcaagcat gtgtaaaagc acttccgctt taatccccgg tacagagaaa 2445601 ttaataatgt gcggcgcgct attcatttga ggcgtgttga taacgacgcc ctcaatttca 2445661 ctcagcctat tcataaacaa ttcctttacg gcagtcatcg tgtcaagccg tgtgtcaaaa 2445721 tcagcagagg ccagattaat ggccttggca agcgaaaccg caccagcagt atgttctgtt 2445781 ccggcccgta tgcctttttg ctgagagcct cccgttatga gcggaataag gcgtgttcct 2445841 tcttttacaa taagtgcgcc tgtccccttt aggccgtgaa atttatgccc cgaaattgaa 2445901 catagatcaa tgccggcctt ttcaattgcc aagggcactt tatagatgcc ctgcacataa 2445961 tcgacgtgaa acaaaatgtt cgaatgctct ttcagcactt ctcctgccgc ttcaatcggc 2446021 tgcacggaac cgacttcatt gttcacatgc atcatgctga caagcacggt atcgggacgg 2446081 atggctgctt ttagatcttc aatagaaaca aatccgtctt cattcacaga aagataagtg 2446141 atatcaaacc cgaacaactc tttcagctgt tctaacgatt ccgtaacgga tggatgttca 2446201 atagaagtgg caatgatatg tttgcctgtt tttatctttg acaaagccgc tccttttaaa 2446261 gccgcattat tggcttctgt ggcgcctgac gtaaatacaa tatcatattt ttttaggcct 2446321 aaggaccttt tgatttgatt tttggctgct tgaagcagct gttccgtttc ggctccatat 2446381 cggtgcaaag atgaaggatt gccaaagtat cggctgctcg tctgttcata tacgttcaag 2446441 acttcatcgt aaggcttcgt cgttgaacta ttatctaaat atatcatctt ttttactcct 2446501 ttatgaaagc ggtacaaggt atgatattta tgttaccata acaaaattta atagaaaatt 2446561 acgaaaaact agtattgact tctaattttt ttaccatata ataagatttg ttcgtttcgt 2446621 catattatct gacaattaat tgacagaata ttttaacata attattagga ggattttttt 2446681 catgaaacac tcactgcctg tcaaagatac cattattatt ggtttcatgc tatttgcgtt 2446741 attctttgga gcaggaaata tgatttatcc gccggaactt ggacaagcag ccggacacaa 2446801 cgtctggaag gccatcggcg gatttttact gacaggggta ggcctgccgc ttctcggcat 2446861 tatcgccatc gcattaaccg gtaaggacgc taaaggcctt gctgacaaag cgcaccctgt 2446921 tttcggcaca atctttactg tcgtgcttta tttatcaatc ggaccattat tcgccatccc 2446981 gagaacagga actgtttcat atgaaattgg cgctgttccg tttttgactg gtgtaccaga 2447041 aagactttct ttattaatat ttacacttat ctttttcggc gttacgtact atttagcgtt 2447101 aaacccatct aaggttgtgg atcgagtcgg aaaaattctg actcccatca aattcacaat 2447161 tattttaatc attgttctca aagccatctt cacgccgatg ggcggattgg gcgccgtgac 2447221 agaagcatat aaaggaacac cggtttttaa aggattttta gaaggctata aaacaatgga 2447281 cgcacttgct tcaattgtat ttggcgttgt cgttgtaaat gctgtaaaaa gcaaaggcgt 2447341 tacacagtct aaagctcttg ctgcagcctg cattaaagca ggtgtgattg ccgctttagg 2447401 cctgactttc atttatgtat cccttgctta tttaggtgca acaagcacaa atgccattgg 2447461 tcctgttggt gaaggagcta aaattttatc tgcgtcttcc cattatttat tcggttcatt 2447521 gggcaacatc gtactcggag cagcgattac agtcgcatgt ttaacaacaa gcatcggcct 2447581 tgtcacatct tgcggccaat atttttcaaa acttattccg gcattatcat ataaaattgt 2447641 cgttacgatt gtcacgttat tcagcttgat cattgcgaat ttcggactcg cgcaaattat 2447701 cgcgttttct gttcctattt tatcagctat ctatccgctt gccattgtca ttatcgttct 2447761 ttccttcatc gataagatct ttaaagaaag acgcgaagtg tacatcgcat gcttgatcgg 2447821 tacaggactt ttcagtattt tagacggtat caaagcagcc ggtttttcac ttggatcttt 2447881 agatgtgttt ctaaatgcga atcttcctct ttacagcctc ggcatcggct gggtgcttcc 2447941 aggaatcgtc ggagcggtta tcggctatgt gctgacctta ttcatcggac catccaaaca 2448001 gcttaatgaa ataagttaat gtcacagaac gcctgcgtta ttgcgcaggc gttttgtaat 2448061 aaaaaaagag cctgctcatt acactgcggg ctctttttca tggtcgtgat tatctaagcg 2448121 gatatgtcag ctttgatttt ttcaactgca cctggcgcag ccttttctac agcggcagcg 2448181 gcaatttcat aagagtcgtc ataatcaaaa gcataaaaac gtctttccgc ttctttcagc 2448241 tgttcagata aaatatgatt ctggcttctg aaccggtttc cgaactgaat gattttttca 2448301 atgaggatga cctgctcgac aagttcctct gattcccggc ttgccctgtt gacgatatct 2448361 tctgcttgtt tcaaatgggc tccggcttct tccatattta atggaagttc gtttagttga 2448421 ttgaccgttt cttgaatatg atgatgcgcg ttctccagca tctcttgaat atggctcgga 2448481 atgcctggaa tgttgctagt cttcagcagt cttgctgtct cagaaattgt ttttttcaaa 2448541 ttgctgagcg tctccctcgc ctgaagctct tcttttctca gcgcttgcag attttcacga 2448601 tactcggcat gctctttttt cacttcttca atttgcttct ctattgaagc aacttcttct 2448661 actaaaagtg agtaggcgac atgctctgca tcaagcttat ctttaacgga tgatagcagc 2448721 tttccaattt catcaaggcg cttttcaaaa gcctgctgtt tgccgagctc accggctgtc 2448781 agcctgtagc tttccttcac cagctcagtt tccgctttcg tatgctcttt ctcttcttta 2448841 agcttgtcgt aagcaataat caattcaggc attttgctta gtacggattg accggcttca 2448901 acttcgccct ccagctgctg ataaacagat tgaatatttt cgtcaatgag ctgcaggatt 2448961 gcggacgctt catcaatatc cagttcagtc atcaggacat gttccgctcg tttcagctgg 2449021 tttgacagat tttctaattc cttatcaagc tggatatgct caagcttgta ccctttttct 2449081 ttcatttcgc catagccatc cttgagcttt gcaatctgtc cgggcaccgt ctgtttacag 2449141 tcagctaaca gcttcggcac atcatctatg tatgactgaa gccgttcaag attgcggtcc 2449201 tgctcaagca gtacttttcg tgcagtaata tagtttccgc cttctgtttc ttcttcaaat 2449261 tgtttgatgc cgctccaaat ttcgtccaga tccttttcaa ggctgtcata aagctccccg 2449321 taaaggtggc tgtaagccag caggtttttt cgagatttcg aatagcgctc cctcacctgt 2449381 tcaatctctt cacggctctt ttcctcactt gtgacaagat cgctgatttc ccgaagaatc 2449441 ttttcaatgc ttgattcagc cgctgtcagc aggtcgtcga tatgaacgag cacttgattg 2449501 gcctttttaa accggtattt gtctgcattt tcctcggcat cataaaggag ctcttcaact 2449561 ttcggcatgt gggctgtgac aatctcatcc cattcttcac gccacttctc aaagaactct 2449621 tctgtctgac ccgtcatttt taaatgtttt attttagaca tttcttccac gatcgaccga 2449681 ttcagaattt caatcttcca cgattccagc cggtcgattt cggcgtagat ttttttcctg 2449741 aaaaagtagc ctgccgcaaa cagcgcaagc agtacaatta ataatccaat gacaaactcc 2449801 ataatgagcc cccttgctgt ttaccttaat ctgtcagggt gttttattta ttcagaaaga 2449861 tttcaggata tgtattgaga aaaactgtcg ttttcattgt tattatgata ccatgtaaca 2449921 aacatttttt gaccagaaat caaaaacttt ttgtgcaaaa tcggcaggat ttgactattt 2449981 tttcatgggg tgacatcaat gcaaaagcga gacggacata ttcacacacc attttgccct 2450041 cacggctcca atgacacact cagacaatat gcagaagaag ccttaaaaaa agggttcgaa 2450101 tcgattactt ttaccgaaca cgccccattg ccgccatctt ttaccgatcc cacgccgctg 2450161 aaagacagcg cgatggcgca agcttctttg gaacgctata ttcatgaaat ttccggatta 2450221 aaaaaagaat atcgcggaca gcttagcata cggacagggc ttgaagtcga ttatatcgct 2450281 gaatttgaag acgaaattac attattccta gacacatacg ggccatattt agatgacagc 2450341 atcttatccg ttcatttttt gcgcacagac tcttcctatc tatgccttga ttatgacgag 2450401 cataccttca aagagctgat ttcagcctgc ggaagcattg aagcggtata tgaacaatat 2450461 taccggagta tctattcttc cattgtagca tctctcggcg tttataagcc aaaaagagtc 2450521 ggtcacatca cactcgtcca aaaattcatc aagctgtttc catacagcat gtcagagcat 2450581 attcgcggcc tcgtttctct gtgcctgaat gccattgaag aaaacggaat ggagctcgac 2450641 ttcaatactt ccggcttaag aaaaacttac gctggcggta tttatatcga ggattggatg 2450701 ctgaatgaag cgaagcaaaa gaagatcccg cttgtgtttg ggtctgatgc ccatcaagcg 2450761 ggagatgtcg gatatgcgta tgaggcgttt ttggaacggt gctagttggt gagcgccacg 2450821 tctcctgtcc ggaagacgct tctgatccaa atcttgattt cttcaaaata cattttataa 2450881 aaatacggct cgtgcggctg catgtagagt acttctgaaa tatattgagg ctggagatag 2450941 ggcatcatca agagagattt taattggaga ataaaatgag gcagcggcag cgttaaatat 2451001 tcacgctgtt tttctccttc ctcaatgatc agctggaaga tatacttttc cttcattaga 2451061 tatgtcgaca taatttccct gattaatgtg gagtcaattg tgacttcccg gtagacaaaa 2451121 cgagttaatt gacgatgatt atgctgatag gataaaatat cgaaaaccaa ttgaagaagc 2451181 tgttcctgcg tgctttgagt agagatattg cttgccgctg tttcaagcgt tttgctgtag 2451241 ccttcgtaaa actctgaaac taagtgttcc atcaagcctc ctttgccttt aaaatagtag 2451301 gagatgtgcg caacatttac atcagctgac tttgcgattt cacggacaga cgtgccagaa 2451361 aatccttttt ggttaaaaag catgacagca gattcaataa ttttgtcttt ggtgcttact 2451421 ttcatacggc tcactccttc ctcttgatac tattcaagca gaaagccgct gttcctgtaa 2451481 gaacttatcg acaaatgccg gcagaaaagc cggaactttg ttttatatta tagaaaaagt 2451541 gagggttttc catgttccat gtcgaaaaac aatctggaga taaagaaaaa gactatcagc 2451601 ttctgctaaa acagctcgaa gccatgaccg aagacgaaac agaccaaata gctaactatg 2451661 caaatgcctc agcactgctg tatcattcgc tgcctgaagt caactgggcg ggtttctatt 2451721 ttgccaaaga agaggatgga cagcttgtgt taggtccgtt ccaaggcctg ccggcatgtg 2451781 ttcggattcc tttcggcaga ggggtttgcg gcacagcgta cgcaaacgga aaagtggaac 2451841 gtattgagga tgtaaacgcg tttccgggac atatcgcctg cgatgcagcg tctcaatcag 2451901 aaattgtgct tccgattcgt gtagacggaa aaattgtcgg cgtcttggac atcgacagcc 2451961 cagtgaaaaa ccgtttcgac gaaattgatg aaaaatactt aactcaattt gccgaaacgc 2452021 tagaaaaagc gttagcgcag taatataaaa gcccaaaact gatatcgttt tgggcttttt 2452081 ttattttatt gagtcatgaa tcatcaagcg gtttttcccg ctccgtttcg cgctgtagag 2452141 cgcttcatct gcctcatgca caagctcttt cagcgacttt tttgtttctg tcgtccagca 2452201 ggagataccg caggaaatgg ttacctcggg tttcgtattt tttctgaccg cgtaaaccag 2452261 tcgctcggta atccgtttcc ccactgcaac cggcacattt ggcaaataaa tcgccagctc 2452321 ctctcctccc cagcgggcac cgacatcatg ctttcggatg ttgcttttaa tcactgaagc 2452381 gacttgaatt aaaatctcgt ccccagtctg atggccgtac gtatcattta catttttaaa 2452441 attatcaata tcaacaagaa taaaaacacc cttttgatgg attttcatgc tgtattgaat 2452501 tttttcatct aaatacgctc gtgaatacag ttcagtcagc tgatctgttt tcacgagatg 2452561 ctcaaggcgg tcgcgaagca ttgaattggt tacagccagt gtcgcgtgat gaatcagcgc 2452621 ctgaaacagc ttgtacattt caaatgtaaa agcgtacagc tcctgtttca ataaaaccgc 2452681 aaagcctaaa agccggtcgt tttgaatcat cggagcagcc atcagcgagc cgtaccccgc 2452741 cttcccaaaa acagactggc cattcccgat gaaaacccct ttttcacctt catacagctt 2452801 ttctttcagc tcattataaa aatctgacgg cttcgcttct ttaaaaaatg ctgtgctgcc 2452861 tgggagcaat gttaggtttt caaaatggtc tatatgaaaa aatcccactt cttctgcctg 2452921 aaacgattct gccattctca cagccagatc attcattgta tcagtcaatg tcagccgctg 2452981 attcaggcgt cgtgatgttt cattaatcaa ttccaaattt gcgatgcttg ctttggattg 2453041 ttcgtagagc tgggcatttt caaacgcttt tcccgcggcg tttgctaaca gcgacatttc 2453101 atcaaggcag gcatcagtaa gaaagctgtc acccgttcct tcagccttca acaccccgta 2453161 tgtgccctgc tgtcctttga tcggaatata ggcgacagat tcatttttcc gcaaaatgtc 2453221 tccggacaaa tacactttga gcgcaaagga atcggatttt tccccttcca tatacagctc 2453281 ttttgcagga atccctaaac attggtcttg atcgtgcgat ataaataaag aaaactcaaa 2453341 aagagaaaat gtgcttgtca agctttctaa aagctgcttc agcacatctg tctgatcaag 2453401 cagtgaatgg aacagctctg tcattttgta tatctttttt tggtagatcg ttttgttata 2453461 gagtctttcc tgtttcatcg actggtttaa aaatgaagca accacgtccg gaagcccttc 2453521 aggaatctct tcatcctgcc tgcacgcaag atggaaacgc ctgccggagc cgtcctcaat 2453581 cagataacat gaagcgttta tttttgaagc ggaaaaacgc gcttcaccat ctgccagttt 2453641 tgtcacaaag tctgatggtg acggtgtaag cgaaacacaa agggttgaaa aataggtttg 2453701 aatagccgaa gtcagccata tgaaagagtc ggtgaatgtg actttttcag atttggttaa 2453761 taaaaaatcg agcatatgat aatgaaaggc ggataattga tctttagttt gttctaccat 2453821 gtttttatca cctaaaagtt taccactaat ttttgtttat tatatcataa acggtgaagc 2453881 aataatggag gaatggttga cttcaaaaca aataaattat ataatgacct ttgtgtgaaa 2453941 tattgcagcc tttttgttca gcttctatgt tttcattttg ttccttatca ataaggtgta 2454001 tcgtgtaact ctctgctgct ggagcgagga tacatgaaaa caaaatgtgc atggtcgaat 2454061 agagcagacg gtttttattt tccacaaaaa taaaaccaaa ggaggagtca cattatggct 2454121 cgctatacag gtccatcttg gaaactgtcc cgccgtctag gaatctctct tagcggtaca 2454181 ggaaaagaat tagaaaaacg cccttacgct ccaggtccac acggcccagg acaacgtaaa 2454241 aaattatcag aatacggttt gcaattgcaa gaaaagcaaa agcttcgtca catgtacggt 2454301 gtaaacgaac gtcaattccg cactttgttt gacaaagctg gcaaactagc tggtaaacac 2454361 ggtgaaaact tcatgattct tttagattct cgtcttgata acgttgtgta caagctaggt 2454421 ttagcacgta ctcgccgtca agctcgccaa ttggttaacc acggtcacat tcttgtagac 2454481 ggaagccgcg ttgacatccc gtcttaccta gtgaaacctg gtcaaacaat cggtgttcgc 2454541 gaaaaatcaa gaaacctttc tatcatcaaa gaatctgttg aagtgaacaa cttcgttcct 2454601 gaatacctta ctttcgacgc tgaaaagctt gaaggtactt tcactcgtct tcctgagcgt 2454661 tctgaacttg ctccggaaat taacgaagcg cttatcgttg agttctactc tcgttaatcg 2454721 ttttaaaaac ccctgccgct atgcggtcgg ggttttttta tcggctttcg cctcttgctg 2454781 gccaacacta tcttgcgcct gctgctccca atgatcccgc tgcagccgtt cttttgcaat 2454841 cgtacacatg agattcacgc tttagcgctc ctttcattta aaaggtggtg attggtcgtg 2454901 tttgccctat ctaatatact cttttccttt cattcctatg cggtaaacaa aaagatcctt 2454961 tgccttcagt ggcaaaggat ctttttctta tttatacgtc acaaggaagt attttttctt 2455021 cccgcggcgc agaacagtaa attggttttc gatgcggtct tcacctgata gggtataatt 2455081 tatttccgtc tggcgttcac cgttaatgta aacagctccg ttttggatgt cttcacgcgc 2455141 ttggcgttta gaaggagata atttagattg caccaacaca tctacaagtg aaagctcttg 2455201 ggtgctgtca acttccatag aaggaacatc tttaaagcct acttttacgt cttgagcaga 2455261 aagctcttta atattgccgc tgaacagcgc ttgggagatg ttgatggctt gctccagcgc 2455321 ctcgcgtccg tgaacaagtg atgtcacttc ttctgccagg cgtttttgcg cttcacgttt 2455381 ttctggcgcc gtttctgttt tttcagcgta tgcttcaatt tcctcttttg aaaggaacgt 2455441 gaagtatttc aagtatttga caacgtcacg gtcgtctgtg ttgatccaga attgatagaa 2455501 ttcatatggc gatgtttttt ctttatcaag ccagatcgcg ccgccttccg tttttccgaa 2455561 cttcgtgccg tctgcttttg tgacaagcgg aatcgttagg ccaaacgctt ttgctccttc 2455621 ttcttctgat tttctgatca gttcaagacc cgctgtgatg ttgccccact gatcgcttcc 2455681 gccgatttgc agtttacagt ttttgtctct gtaaagattt aagaaatcat aagattgaag 2455741 aatcatgtag ctgaattccg tgtacgagat gccggattca attcttgagc tgaccgtatc 2455801 ttttgccagc atgtaattga tgccgaaatt tttaccaacg tcacgaagga aatcgatcac 2455861 attcattttg ccgatccagt caaagttgtt cgcgatgaca gctgggtttt ctgctgcttc 2455921 aaaatctaga aatctggaca gctggttttt gattttttgg gaccattcgg atacgatgtc 2455981 agcagtgttt aatgtacgct ctgctttttt tccgcttgga tcaccgatga ggcccgtcgc 2456041 gccgcccaca agcgcaatcg gatgatgccc tgcaagctga aaacggcgaa gtgttaaaat 2456101 aggcagcagg tgtccgatat gcaagctgtc tgctgtaggg tcaaagcctg agtacaagcg 2456161 gattttttct tcattcagct gtttatttaa cccttcttca tctgtcattt gctgaatcaa 2456221 tccgcggaag gataagtctt caagtaagtt agtcataaga taaagctcct tttttaatta 2456281 aaataaaaaa cgccccttcg tttacacgaa gggacgattg attatcgcgg taccacccta 2456341 ctaataagag aatgcaaaca ttcgtcttat cactttgcct gataacggat caggtccgtt 2456401 ctttcactac tgaaagcctg gccggctttg tttgcaaaag cggttcatga gtgtattcga 2456461 tatatccgtc tgtgctgatt ttcaccggcc atcagctctc tggaacgtaa ggatattcta 2456521 cttgtctcaa tctttacctt ttcatatgaa gctatatcat ttttaacata aataaaatcc 2456581 tgtgtcaacg ccgcctttta atcctccatt gttgacagat ctccagccgg cagattaagc 2456641 tcccatgcct tcagcacgcg cctcatgatc tttccgcttc tggttttcgg aagcttatct 2456701 ttaaattcga tctcacgcgg agccgcatgg gctgcaagac cctgctttac aaataggcgg 2456761 atctcttctt tcagtttatc agacggctca aatccttccc tgagtgcaat aaaggcttta 2456821 atgatttctc cacgcaccgg gtcaggcttt ccgataacgc ctgcttctgc aatagccgga 2456881 tgttcgacaa gcttgctttc cacttcaaat gggccgacgc gctcaccgga ggtcatgatg 2456941 acgtcatcaa ctctgccttg gaaccaaaag tatccctctt catccatgta agcagaatcc 2457001 ccagacacat accagccgcc cggcatgaaa tacgattcat acttttcagg gttattccaa 2457061 atggtatgca tcatggaagg ccagcccttt ttgatggcga gattgcccat tcggtacggc 2457121 ggtagctcgt tgccttgatt gtcaacgatc gctgcctcca ctcctggaat cggcttaccc 2457181 attgaacccg gtttaatatc catgcaagga tagttgcaga tgagctgact gcccgtttcg 2457241 gtcatccacc aggtatcatg gattcgtttg ttaaaaactt tatgtcccca tctgatgact 2457301 tccggattta gcggctcacc gacactgagc acatgccgga gtgaagttag atcatatttc 2457361 gcagccattt catctcccgc tcccatcagc atccgaaaag ctgtcggcgc gctgtaccag 2457421 acattgacgc caagctgttc aatcgttcca taccagcttt ccgggctgaa acgtccgccg 2457481 acgatgacat ttgtcgctcc gttcagccac ggtgcaaaaa tgccgtatac cgtacctgtc 2457541 acccagcctg gatcagccgt gcaccaataa atgtcttctt cctttaaatc aaggacccac 2457601 tttcctgttt gatattgctg aatcatcgct tcatggacat gcaacacgcc ctttggcgta 2457661 ccagtggaac ctgatgtata gtgaagcaga aagccgtctt ttttatccat ccattcgata 2457721 tccaatcttg tgctttcctg tttcgctgct tcatcataat tgatgatatt cgtgccgctc 2457781 tcagcctctc ccccgactac gaagacatgc tgcaagtgag gcagtttgtc taccggtatt 2457841 ctctccagca gctcaggcgt tgtgacaaca acctttgcct cactgttttc aagccggtct 2457901 ttcaccgctc cctccataaa tgcttcgaac agcggcccgg cgatggcgcc aattttgatt 2457961 gcgccaagca taataaaata aagctcgggt gatctcggca taaaaataaa aacgcggtcc 2458021 cctttttcca catttccata ccgtctcagc acattcccgg ctctgtttga ttcttccttc 2458081 atttctttaa atgtgtattt ttcatccctt tttgcgtctt tataataaag cgctactttg 2458141 ttttttcgaa acgattcggc atggcggtca atcgcttcat acgccgcatt cagtttccct 2458201 gtctcatgcc aagagaaatg tttctctgcc tcggcccaat caaaatgccg gtacgtttct 2458261 tcatagtttt ttaagttatg atccccctct attgctggta acgctttcaa gttcatgccc 2458321 aaacatcccc ctttgctgaa gttgtcacaa ttattatagt atatattcat attcttctca 2458381 atttttaaaa tataaaccat gttgaaaacg ctttataatt tggtattctt aaagaaggca 2458441 tgtatttttg ataagaattg atgggacggt gaattagtgg aacatcataa aacataccat 2458501 tcagcaaaca tcaaaacagc aaccggctct ttactgatag aagggcctgt ctctccagag 2458561 gatttggcag gttatgagtt tcataaagat ttaaccgcat ttcgcccgcc tcgcgagcag 2458621 catgaagcgc tagtcgacat tgcaggcctt cccgaagggc gcattattat tgccagagac 2458681 ggccgaacca ttgtcggcta tgtcacgtat ttatatcctg acccgctcga aagatggtct 2458741 gaaggaaata tggaggattt gattgagctc ggagccatcg aagtagcgcc ggactatcgg 2458801 ggatgcgctg tcggaaagac gctcctgacc gtcagcatga tggatgaaca aatggaaaac 2458861 tacattgtga tgacgacaga atattactgg cattgggatt taaaagggat gaaaaaagat 2458921 gtgtgggaat acagaaagat catggaaaag atgatgaatg caggcggatt ggtctggttt 2458981 gcaacggatg agccggagat cagctcccac cctgcaaact gtctgatggc ccgcattgga 2459041 aaaaacgtca gccaagaatc aattgagcaa tttgacaggc tccgttttta tcatcgttat 2459101 atgtattaac tgacactgac aaaggggaaa aaataatgat tgttgagcaa atcatgaaaa 2459161 gagatgtcat tacattaacg aagacggata cgcttgaaac agcaatatgc aaactgaagg 2459221 aattccatat caggcatctg cctgttgtag atgaagaacg acacgtgatc ggcatgatta 2459281 cagacaggga catgaaacag gccagcccga gtatttttga agaaaacaaa cgaagcctat 2459341 ttctcacacg aagcgtagat tcaattatga aaaaggatgt tgtctgcgcc cacccgttag 2459401 attttgtcga agaaatatca gccgtgttct acgagcatgg catcggctgc ctaccagtgg 2459461 tacaccatca aaaattaata ggcattttaa caaaaaccga tttgctgcgg acgtttgtca 2459521 aattgacagg cgctgaccag ccgggctcgc aaattgagat aaaagtaaac gacatcacca 2459581 aaagcctcgc tgagatcagc agtctttgcc aagaccttca agtgaaaata ttaagcgtgc 2459641 ttgtttatcc gcatgacgat cccggtgtaa aagtgcttgt cttccgtgta aaaacgatga 2459701 atccgctgcc gtttttgcag gcattacaaa gaaatggaca ccacgtcgta tggccgtcag 2459761 agcaaaggga tctgctatga gagacagtgt atttatctat tctccatcct accaaaccta 2459821 tatgtttcat caggagcatc cctttaatca gcagcgggtt ctgttaacat atgatttgct 2459881 taagacgatc aatgcctttg atgatggaga cattgtcacc cccagactcg cttcagaaga 2459941 ggagctttcc cttgtccaca cggacgatta cattcaggcc gtaaagcttg cgggcgccgg 2460001 aaagctcccc gctgaagaag gagaaagcta cgggctcggc actgaagaca cacccgtctt 2460061 tgccggcatg cacgaagcgg catcactctt ggtcggcggc actttaacgg ccgcagactg 2460121 ggtcatgtca ggacaagccc tgcatgcggc aaaccttggc ggagggcttc atcacggctt 2460181 tcgcgggaga gcatcaggat tctgcatata caacgacagc gctgtggcta ttcaatatat 2460241 ccagaaaaaa tatagcgcca gagtgcttta tattgatacg gacgcccacc acggggacgg 2460301 tgtgcaattt acattttacg ataatcctga cgtatgcacg ctgtccattc atgaaacagg 2460361 aaggtattta ttccctggaa ccggtcagat ccaagaaaaa ggaagcggaa aaggatatgg 2460421 ctattccttt aatattccgc ttgacgcttt tacagaggat gattcttttc ttgaggctta 2460481 ccggacagca gcttcagaag tcgccgcgta tttcgagccc gatgtcatta tcagccaaaa 2460541 cggcgccgat gcccattact acgacccgct gacgcattta tcagcaacaa tcaatatata 2460601 cgaagaaatc ccccgtcttg cacacacttt ggctcatcaa tattgcggag ggaaatggat 2460661 tgcagtcgga ggcggcggat atgatatttg gcgtgtcgtg ccccgcgcct gggccagaat 2460721 atggcttgaa atgaagggaa ttgacccggg tcacgagatc ccgccggaat ggattgttaa 2460781 atggcaaaaa caatgccccg tggcccttcc gtcgagctgg agcgatccgg ctgatttata 2460841 tcctccgatt ccccgcaagc ctgaaattac agaaaaaaat gcccaaactg tcagcaaagc 2460901 attatatgcg atacgttctg aacagcaaag aacaaagtaa aaaacgacct ttacgaagag 2460961 gtcgtttttg attttttaat cactatttcc acacgccgat tttccttcat gtgttcattt 2461021 gtcttgttat cctttactgg ctttgtatcc gcataaccga cagcaataaa gcgcttggag 2461081 ggaagcttct ctttagacgt gaagtattga atcactccac ttgcccgtgc tgctgatagc 2461141 tcccagttcg acgggtatcg gtatgtcgaa atgtttcggc tgtctgtatg tccctcaacc 2461201 tgaatgtcat ttggaattgt ttgaagaaga acggcaattt ggtgaagaag tgtttcggca 2461261 tttttcagca cctttgcctc acctgtatca aacagcacag cctcctgaag aacgagcacg 2461321 acaccgcgtt catcccgttt ggctgtcatt tgggccttca aatgattgtc ttttatatat 2461381 gtatttactt tcttgagaag ctgatcctgc tgatcctctt gcttcttcgt atcagatggg 2461441 gatgtattct ttttttctat ggatgtttgg tccggctgaa gcccgttgcc ttccttctgg 2461501 atcgagtcca ctgccgcttt gaatttttgc agatcgattt gggacatcga aaagagtaaa 2461561 ataaagaaca caaggatcaa ggtgatcaga tctgtaaagg ttaccatcca gctggatgaa 2461621 gattgactgt tttttccgct tccattcctt ctttcaaaac gttctcttct aagcttcatg 2461681 tacagatccc ttttttgttt ttacttgttt tggctgcttc tgccattctt cccgtgagct 2461741 gaaaacgacc agctggcttt caaggttgcg cgggtttttt ccggattgaa caccgataat 2461801 cccttccacc attacctgct tgatgaaaat ttcactttct gttttctctt caagcttagc 2461861 cgcgatcggg ttgaagacca tatttgccag taatgaacca tataaagtcg tcagaagcgc 2461921 aatggccatg tttggtccga gcatatgcgg gtcgtttaag tttttgagca tcagcacaag 2461981 cccgacgagt gttccgatca ttccccatgc cggagcgaat tctcccgctt tttcaaaaac 2462041 tcgccgccct tttcggtgcc gttcctccat tgctgcgatt tctgaatcca tgacgagccg 2462101 aatcgtttct tcatcccagc cgtcaatcgc taaaagcagc ccttttttca agaatggatc 2462161 tttgatttcc cgagcctgat catccaatga taaaagcccg tgttttcgcg cgtgatcgga 2462221 aagggaaaca aaggttttca caagatcttt cacattgtct tcctggcgga tgaatgcctg 2462281 ctttaacaca gagggcgctt ttttcagctc acttggcgga aaactgataa aaacagcggc 2462341 gcaaagtccc cctgttacga tgaagaaaga ggtcagatca agaaaagagc ggaaaccgct 2462401 tactcccgat cctgaaataa tcccgataac aataataatc gttcctaaca caaatccaac 2462461 aggtgtaaga taatcaaaac gtttcatcat ttctccccat gaaaaaagca agaattcacc 2462521 ataaaggtga agcttgctct ttgtttttct tatgacttgg ttgactttct aagctctata 2462581 cggtgcggca gttcgacgat atgctcttca accggctctt tattcatgag cttcgtcagc 2462641 agtctcatcg caacggcgcc gatatcatat gtcggctgaa caactgttga aagctgagga 2462701 cgaaccatga ggcttaatct tgtattatca aaaccgataa tgtcgagatc ctccggaatg 2462761 gataagccct gatcctgagc ggcatggata atgccgagtg ccatttcatc agttgcagaa 2462821 agaatggctg tcggtttttt atccaggctc atcagatgct gcagtgcttc gagtccggaa 2462881 tcatatgtgt aatccccttc agctacaaat tgttcattaa acggaaggtt cgcttcttca 2462941 agcgcacgtt tgtagccttg gagttttttc gaacggttga tcggttctgc cattggtccg 2463001 gaaacgaacg cgatgtctgt atgtccttta tcaaccaaaa gcttcacggc atcataaatc 2463061 gcctgttcgt aatcgatagc gactgacggt gtttcctcct gctcttctac agaagcggca 2463121 agtacaatcg gcactggaga acgcttaaat tccgccacat gctcgtccgt aatgtttccg 2463181 cccataaaca cgatgccgtc cacttgtttg ccgagcattg tgtttaacaa gtgcagctct 2463241 ttctccatgt tttggtcaga gttgctcaaa ataatattgt atttatacat tgtcgcgata 2463301 tcttcaattc cgcgcgcaag ctctgaatag aaaatgcttg agatatcggg aatgatgaca 2463361 cctacagttg ttgttttttt acttgccagc cctcttgcca ccgcgtttgg acggtaaccg 2463421 agacgttcaa tggcttccaa gacttttttc ctcgttgtcg gttttacatt cgggttgccg 2463481 ttcacgacac gggaaacggt tgccatgctt acattagctt ctctcgctac atcgtagatc 2463541 gtaatattgc tcatcctaaa accactcctt ttactggata cacttatcct tatctatagc 2463601 ataaacactt tatgtagaga aatgtcataa tgtccgaatt tatgtcgttt atgatttgta 2463661 agcgtaagtc agtagtgtac attatttttc attattcatc aaatttaatt acttctcatg 2463721 aaattataca cgtttttata gatgatgaaa acgtatactt ggtttttata actaaataaa 2463781 cgagaaagca taaaaaaagg ccgcaggcgc ggccttttgg attgttcaat taagcgttga 2463841 ctttcaccat tggcttcagt tcattcagcc atttttcgaa ttcaggaatc gccatttgct 2463901 gagcagagtc agaaagtgcg actgacggat cagggtgaac ctcagccatt acgccatcag 2463961 caccgatcgc taaagcggct ttagctgtcg gaagcaagag gtcacggcgg cctgttgaat 2464021 gcgtaacatc aacaaagact ggcaaatgcg tttcttgttt caaaatcggc acagctgaaa 2464081 tatccagcgt gtttctcgtt gctgtttcat atgttctgat tccgcgctca caaaggataa 2464141 tttggtcatt tccttgtgac atgatgtatt cagcagcatt gatgaattca gagatcgttg 2464201 cagcaagacc gcgcttcaga agcactggct ttttcacggc gccggccgct ttcagcaatt 2464261 cgaagttttg catgttgcgc gctccgattt gaatgacatc aatgtagtcc agcgcttctt 2464321 cgatatgagc cggagttacg atttcactga taaccgccag atcaaattca tccgctacac 2464381 gttttaaaat ttgaaggcct tcaacaccaa gcccttggaa atcgtatggg ctcgtacgag 2464441 gcttaaaggc tccaccgcgc aaaattttaa tcccttgttt tttcgcagct gcagcgactt 2464501 cagctacctg ctcatagctc tctaccgcac atgggccgac aatgaatctt tgctggccgt 2464561 ctccgatttt ttcgcctttg atatcaacaa ttgtatcttc aggttttttc ttgcgggaga 2464621 caagcagcgc tttgctgtga tcttcttcct gaagctctaa accggctttg aatatctctt 2464681 taaaaatgtg ctggatggtt gaattttcga acggcccgtc attgttttca atgatattgt 2464741 ttaacattgt gcgttctctg acagggtcaa atcggttgac accctgtgct tccttcgctt 2464801 taccgatctc ttttacaaca ttgccgcgtt cgttgattaa ttttaaaatt tgtaggttta 2464861 attcgtctgc tttctgcctt aaaagctcta actctgtgtt gctcattttt ttcatccttt 2464921 ccctgcacat tcatttttta ttttgtagtt atcatgcatc ttactataag taattccaaa 2464981 tggaaatact gaaatacaaa aaattttata aaaactctac tttattaccc aaacgctttt 2465041 aagtgataaa gtaatctatg aagctatcct acatgatgtg agggcaatgt tcaagggttt 2465101 tttacaaaaa aaagcgccag atgatatctg gacgcttttt tctatgacaa atgctgctca 2465161 atagcggctt ctgtaatttg tgaatgtgag gtatgccatt tcacttcacc gttctggatg 2465221 atgaatatct gagggctttc atgcttgacc ccatatgttt ctgcaatgaa attggacagc 2465281 ggccgggctt cttgtacttg aagatagtaa gccggcacat cctcatgctg atttgcaaag 2465341 gcatcaaact catgaaatgc tgcctggctg atcgggcatg tggtgctgtg tttcaagaag 2465401 acgaaaacgc cttcctgttc tgcaatccgt ttaaattctt cctcagattg aataagctgt 2465461 ttagccatga ctcaagctct tccttccctg ctcagcgatt caactgctca gcctgttttt 2465521 gtgcatcttt cagttcgtct tttacatctt ctttcgtctg gaggacttga tcttttgttt 2465581 catcagctgc ctgcatcgct tcttccctca tatcttgcat tgcagtcgat gaatccgttt 2465641 tgtcagattt ggaacggtct ctcaaatcct ttaccttgtt catgatctgt ccagactgat 2465701 ccgctacaag ctgtgtgatg ttggaagttt tgtcttttgc gatgctgaca tattgcgtgc 2465761 ctttttcctt cgcatctgcc gtcattttat cagttttgtc ccgtaaggca acagcctggc 2465821 tgccgagatc gtcgcgaagt tctttgcctg atttaggcgc tagaaaaaga gctgtagtgg 2465881 caccgatgat tcccccgatt aaagttccga ttaaaaaatc tttactatta attccatctt 2465941 tgctcatcat tattcctcct cttagtattt ttttctctta cagggctgat tttttctttt 2466001 gcttccattt ctcccaaatt tccattgctg cttgactcca agtgacaact tgattgatct 2466061 tatcttgatt ctctctaact gatgccgata cagaccctgc cgcttgtttc atggatgtat 2466121 tgaactgctg tacagaagct cccactcctt gaacagcatg aacgaccgtg ttcagctttt 2466181 ctgatttttc ctgaatatct tcagccaggc ggttggtctt atgtaaaagc tcggctgttt 2466241 cagttgtgat gcccttcatt tgtccctcca gcccttcaag agtggatgcg acgtttttta 2466301 gtgtcagctg cagtgacttc aatgttttag acaagtagat cactaatacg agaaatgcaa 2466361 ctgcgatgag tgcaacgctc aaataaagaa taataatcat ctcaaacctc cttgctgcag 2466421 gatatactgc tgtttacccg ttttcttcaa tcataaacat gtgtactggg ctgtatacat 2466481 actattctcc gttatgtaag aaaatccttt aataagcttt cccatcagat aaataaaaag 2466541 cagtgagatc actgcttttt attatgccat gacgttttcg taggctctca tatatttttg 2466601 gatatctcct gctcccatga agatgagaac ggctttatca tgagctttta aaacagatgt 2466661 gtcatcttct tcaatcagct tggcattatg aatttttccc tggagatcac cgatcgtcag 2466721 ctttccggca ttctcacggg ctgagccgaa aatatcgcat aaatacacac agtcggcgcc 2466781 gctcaggctt tctgcaaatt cgtcaaggaa ctgctgcgtc cgggtaaatg tatgaggctg 2466841 gaataccgcg acaatttccc gatcaggata cttctgtctt gccgcctcga ttgtcacttt 2466901 tatttctgtc ggatgatggg catagtcatc aatcagcact tgatccccaa gctgcttctc 2466961 attgaatctg cgtttgacgc ccccaaagga tttgagagca tgcttaatga tgctggaatc 2467021 aatttcttca taatggcata acgcaatgac cgccaatgag tttaatacat tgtggtggcc 2467081 gtacgcagga atataaaacg tatcatagaa cgtattgcgg acaaagacat caaaagttgt 2467141 cccttccgtg ctttttacga tgtttctggc ttgaaaatca ttttcttccc ccgtgccata 2467201 atacacaacc gggacgttcg catggatttt cggcagatgc tcatcgtctc cgcaggcaat 2467261 aatgcctttg ttgacttgaa gagccatctc ttggaaagcg tcaaatacat cgtcaatgct 2467321 tgagaagtaa tcagggtgat caaaatcaat attcgtcata atcgcataat ctggctgata 2467381 gcttaagaaa tggcggcggt attcgcacgc ttcaaacaca aagtattcgc tgttttcatt 2467441 tccctggcct gttccgtctc cgattaagaa agacgtcggt tttgcgtttt ggatcacgtg 2467501 agccagcaga cccgtagtcg acgttttgcc gtgtgcgccc gtaacggcaa cactcgtgaa 2467561 ttttttcatg tagtcgccta aaaacttatg ataacgtatc accggaattc cctcagacat 2467621 cgctttttct atttcaggat gcgtgtctgg gaatgcgttt ccggcgatga ctgtcatgcc 2467681 gggtttaata ttttccgcgc taaaaggaag aatcgtaata tttctttttt caagcgctgt 2467741 ttgcgtaaaa ataaattttt cgatatccga tccttggaca gtatatccat tatcatgaag 2467801 tatttgggca agcggactca taccggtccc ttttattcca acaaaatgat aaacagtcat 2467861 aattgtacct ccaacaaacg tctatctgtt ccccagtata tgacgctcat ttcaatttgc 2467921 gaccgcggcg gctgaaaagc ctcccttagc ggcgtatttt atatgttttg ttatgtttag 2467981 tatcaggtta tttctttccg attaaaccca gatatcaaga tttgtctatg cacagctgct 2468041 gtaaagcggc atagctgtta aatgctctaa acactatcat accatgtttg gtgtgaaaat 2468101 gaacccatat tattcgttta ttaaatcact tgctgtgatc agcacctctc gaggcttgct 2468161 tccttttgcc tcagagatca tgccttccgc ttccatcatg tcgatcagcc ttgccgcacg 2468221 attgtaaccg attctgaatc ttctttgcag gcttgaagtg ctcgcactgt tttgctctac 2468281 aacaaactca cacgcttcgt aaaacagttc gtcctcttct ttcagggcag atccttgtct 2468341 tacgagctct tcttgttcaa ataaataggt cggcggcatt tggcttctga cgtgggaaac 2468401 gacgcggtcg atttcccggt ctgacacaaa gttaccttgc agacgaaccg gttttcccga 2468461 gccgttttcc aaaaagagca tatccccttt tccgagaagc ttttctgcac cggctatatc 2468521 aataattgtt cgggaatcaa cctggcttga gacagaaaag gcgattctcg ttgggatatt 2468581 cgccttaatc agacctgtaa tgacatcgac tgacggacgc tgagttgcga cgagaagatg 2468641 gataccgcac gctctggctt tttgggcgat ccgcgcaatg ctttcttcca catcgtttgg 2468701 agccaccatc atcaaatctg caagctcatc aataatgaca actaaatacg gcagcttttc 2468761 acccatttgg tgttcagcgg ttaattgatt aaagcggtca atgtcgcgga cacctgaatg 2468821 ggcaaaaagc tcatagcggc gctccatttc ctcaacgacc catttcaaag cagccgtagc 2468881 cgctttagca tcagtaatga ccgggctgac gaggtgagga attttattgt aaggggccag 2468941 ctctaccatt ttcggatcaa tcagcagcac ctttacctca ctcgggtcag ctttataaag 2469001 caggcttact aatattgtat tgatgcatac gctttttccg gagcctgtag cgccggcaat 2469061 caagccatgc ggcattttct tcaagtcgat aacaacagga tttcccgaaa tatctaatcc 2469121 cagcgcagct gtgagcggtg acttgcttgt cctgaaagct gagctgcgaa tcatttggcg 2469181 caaatcaacc accttgctcg tgcggttcgg cacttcaatt ccgatcgtgt ttttccccgg 2469241 aatcggcgct tcaatccgaa tatctttagc tgagagactg agtttaatat catcggacaa 2469301 gttggtgatt ttattcacct ttacacccgg ttcaggatgc acttcaaatc tcgtgacaga 2469361 cggaccctgg gttacatgga ccacattggc gcggacattg aaatttttca aggtcaaatc 2469421 aagaagctga cgctgttctt cgatccacgc agtatcatct tgaacctgcg ctggcgggac 2469481 atcaagcagt gcaacattcg gaaatacata gctgccgcgg cgctcctctg ctttttgctg 2469541 tttatgcgta tctcttttca gcatcatcac attaaaagga acggatggcc ctttttgaga 2469601 agatgcgctt tgttcagtcc ttttctcctg tacaccaggc ctttttttcg gctcttctga 2469661 agcttcgcga ggtttgtctg cgcgaatttc ctgccggttt tcaagagttg cagtagacga 2469721 tttggaaccc tgctccatgt gttcagtttt ctcaagctct gtatggctgt ctggctgaac 2469781 atctatcttc gtttcctgag cctctcccag ggtgtcataa tgattattta ttatgctttc 2469841 tgatggctct tctgattctt ttgccacagt ttctgcttga gccagagcct ctgatgaata 2469901 ctcatgatca gtaaataaag gctcttcctg acgaatgtcc atttgttctt cttgaacgaa 2469961 cggggactca gcaccttctg ccgcgttttc atgatgattg tatactgggc tgtctgacgg 2470021 ctcttttgct ttttcatcct cagatactgc ctctgtctga gattcaggag ctgtttgctc 2470081 ttcatcaagt tcagcggaga aaacaggctc ttcaaatttc tctggctgct gctccctttg 2470141 ttcttcctca gccgttgcag gctcttcgcg gcctacttca ctgtctgaaa gcccttcagc 2470201 cgccgtatct gtgagcatct caggcggtgt ttgctcttcg gcttgttcag ctgggaagaa 2470261 aggctcctct ttttccggct gttgaacgcc tgactcaaat ggcactttgt tacctgacgg 2470321 ctcggctggc cgtttcgcca gcgcctcatc atgctccgta tcctttctgt ttaaaacgcc 2470381 agaaggctgt ttttcaaatt gggtatccgg gaagaaagga ctttctattt tggaatgcgc 2470441 ctgtgtgtct gaagcaggat agccgcgttc acgttcgatc tcttctgaca gcagtgttac 2470501 cttctctttt accgatttat ccggttcgtt caatgtttca gaaggctttt tcggcacatc 2470561 ctttttaaca gatggttttt gattgaatcc atagacaggc gaagggatat ttgtcggttt 2470621 aaacggtttc ttcgccggct ctgctgcttg atatgtatgc tgctcttctt catttctggg 2470681 acgctctctg taaggtgcag cacttggacg aggcgcggat ttcggttcgt ccgatggtgt 2470741 gcggcgcctt ctcaggtcat gatttttgta tccgtcaggc acgactggaa aacggaattt 2470801 gccttttgga tattcataat atattttagg atcttccaat ctttttaatt gtccttcagg 2470861 atgatgtact tcttgttgct gcggaatttg agcgggtttt gtctcccgtt cagcatcctc 2470921 ttcgctttcg cctaaaaaca aatcaaaaaa tttatgaagc caactcataa tttatctcta 2470981 actcccttat agttttctgg gacggttttt agtataccac tgctggtcgg cccagaaaag 2471041 attaagctat cagcagaaac aaagccgcta aacaagggct tagcggcttt tcacatgatt 2471101 cgtttttttt ggcggattta tgggagtcta aaactgaaat gcgtctcccg cctcatagtc 2471161 tccttctaac acaaggattc ctttttcagc aggggcatcc ggcaaatcaa gctctttcgc 2471221 tgagcagatc atcccgcttg acggaacgcc acgaagctct gcatccttaa tgacaagtcc 2471281 gctaggcatc acagcaccga ctttggcaac gacaactttt tggccttggt caacgttagg 2471341 cgcgccgcag acgatctgaa gcgtttcttc tcctacgttg actttacata cgcttaattt 2471401 atccgcattc ggatgttttt cttttgattc tacataaccc acaacaaact tcggagataa 2471461 atcaacgact aatgtttctt caacgccgtt tctgtttaaa atctcattca catcttgcac 2471521 gaatgtttct gagagcgcaa cagggccgtt ttcatcaatg gtcaagtaag aagacgcatt 2471581 gaaaatgttg aagcccgttg tttcttttgt ttcgttattg aaaattttga cgacgtcgcc 2471641 gtgtttttca tagcctaatt gttcgcgtgt cacatcttga agagagatca ggagcgtgtc 2471701 tcccacacct tctttattat aaaaagcgtt cataagtaaa aatcctttct aatccttttt 2471761 cggacggctt ttcgccagga taaacaccgg ttccagcttt ccttcattgt acaaaaatga 2471821 tagggcggta atcgggacgg tgccgcctgc aaagaagctc atcgacattt gtcctagaat 2471881 atcatacccc gattcattcc ggatgtcagc aagaatcaaa acgtcctgat gaggaacaga 2471941 gatcgccagc tcaccttctg catgctgctt atactcattt aagatcgctt cgttcaaaat 2472001 ccggcttgcg tcgtatccgt cgtttgccct gaagaaataa aagtaattgc cggcaaccgt 2472061 atcctctttg acaaccgtcg gcagggaacg gagattaaat gcggccgtct ctctgatccg 2472121 ctcttttgtc cagttttctt tctcaagcat gcgctggtca attaaacggt aggttttccc 2472181 gagatctagc gcgtaataaa ttcttgtctc tgcggtatga tcgtcataaa tgagcgggat 2472241 atcttcgctg gacttgtccg ggaaggaagt cgagcggatg accggataaa tgcgagtttc 2472301 tttcccggtc atttcctgag ccttcccttc cattgccgtc atcgcttcgg agacatagta 2472361 cacgatctca tcaatggctt cgtctttttt cagttcccat tttgcaataa tcggcggcaa 2472421 atcgagtgta atcccttttt tagtcgtttg atcctcaaca cggagggtgt ctttttctct 2472481 gtcaaacaga aaggagcgat tctcgtgctg aaggcgctgc ttcagtatat ctgacagctt 2472541 ccttgaggtc attttcaaac cgatgtcctc ctttacgctt tagcgagaga gtctgttaaa 2472601 aactgttcaa tttcttcttt tgttttgcgg tctttgctca caaaacgatt tacttctttt 2472661 ccttcattaa acaccacaaa gcttgggatt ccgtaaattt cccactctgc acatgtatca 2472721 atgaatttgt cacggtctac gtagtagtag gtgaattcag ggaaattcgc ttccagttca 2472781 ggcaggaaag gctctacaaa acggcaatcc gggcaccaat cggccgaaaa cataaataca 2472841 gaccaatcat cctttaccgc tttttccagc tcttgagttg attcaatttt tttcatttca 2472901 tatccctcca gttgtttatg ttcttacatg ttttttatcg atactcgtcc atttggatca 2472961 taccaaactg cttgaggcaa aaccacttat atgcaacgaa tgaatatgta agattggctt 2473021 tcccattatc attatcatat tttatttgca ttatcaagct cgtttcgttt aacatcgtgt 2473081 acatgagggt gaaatttaca gatggatata cataaggagg gatttttatt atggagttta 2473141 tcgtctattt agcaggagaa atccacagca attggcgcga ggaaattaaa gaaaaaacaa 2473201 aatcactgaa gctcccgatt acgtttgttg gcccgatgga gaatcatgac cgctcagaca 2473261 atattggtga agaaattatg ggcgtacagc caaatgccgt tttaaaggat gacaaagcct 2473321 ctgacatcaa caacttcaga accgccgtcc tgatgaataa agcagacttt gtgatcgccc 2473381 tgtttggcga aaagtacaaa cagtggaaca cggcaatgga tgcatcatat gcgatcgcaa 2473441 aaggaaaacc cctgattatc atccggccgg aatcgctcca ccatccttta aaagagcttt 2473501 ccaataaagc gaatattacg gttgaaaccg ttaaccaagc cattaaggcc ctttcctatc 2473561 tatttgaaac agaataagaa aaaagcttgt cgatccgggc ttactgctcg ttcaacaagc 2473621 ttttatgaaa cctacatatt ttctttaatc gcatccactg tctgcttatc gcaggctgtt 2473681 acaagtttga tgagcatttc tttagcagca gcataatcat caatatgaat gatagtagcg 2473741 tttgtatgaa tatagcggga acatattccg ataaccgctg acggcacacc gctgttcgaa 2473801 atatgaacct tgcctgcgtc tgttcccccg ccggatacaa aatattgata tggaatatca 2473861 tgcgtttcag ccatatcaag aacgaattcc ctcattccgc gatgcatgac tgtcgttctg 2473921 tcaagaatgc gcagcaaaaa gccttttcca agctggccga attcattttt gtctccgctc 2473981 atatcgtttg ccgggctggc gtcaagggcg aaaaacaagt ccggtttaat catatgagaa 2474041 gccgtctgcg cgccccttag ccctacttct tcctgaaccg ttgcacccgc atagagtgta 2474101 ttcggaagct ctttaccgtg taattccttc agaagttcaa tgcttaagcc gcatccatat 2474161 ctgttatccc atgcttttga taaaattttc ttttcattcg ccatcgtcgt aaacggacaa 2474221 acaggcacga tctgctgtcc cggtctaatg ccgattttga tggcgtcttc cttatcatcc 2474281 gctccaatgt cgatcatcat gtttttgata tccatcggtc ggtttcgctg cgcatctgtc 2474341 aataaatgcg gcggtatgct tgaaatcaca cccggaaccg gcccgttatc tgtttgaatt 2474401 tcaacccgct gcgcaagcaa aacttggctc caccagcctc cgagcgtctg gaatctgagc 2474461 agcccgttgt ctgtaatgga tgtcaccatg aagccgactt cgtccatgtg cccggctacc 2474521 ataattctcg gtgcgtcctc tgcgcctcgt ctgactccga aaacacttcc cagtctgtcc 2474581 tgaacgatgt catctgcata tttggctagc tcctgcttca taaaagcacg aacctgatgc 2474641 tcattgcccg gcgcgccggg aagctgcgtc agtgtttgga aaagcgcttt cgtttcttga 2474701 ttcatgtttt cccctcattt ctatgtagtc cttttatttt attagaaaca atgaagtttt 2474761 ccaagcactc tgacccaatc tgctcgatca gccgcgtatt gcttaacagg atttggctgt 2474821 ttctgtataa tgaaaagtac gatcaaccag gaggtgcttt attttgaaat tgcgtcatct 2474881 tcttttagga gcaggacttg gaatttgtac ggctgtcgtt gtgagacaat atgtgatgaa 2474941 gccttatatt tcttcagaaa aagcgcttcg aattgtaaaa tctgctttta agcagcgggg 2475001 cccgattgac ggatcatgga tttacaccca gccggagccc tacaatatta acggagaaac 2475061 ggtacaggta tacaaaaccg gcattacacg atcagctttc ggagaattag aacagtatga 2475121 agtcatggtg gatgcgaaaa cgggagaaat tgttgatgtc attgatacaa tcgcctctta 2475181 acaccggaca agcaaaaaat agaagccgct gcctatgcag cggctctttt ttattatatc 2475241 gcgcgaatcg gtttgtatac cggataccac atcgcatcct gcactgcctg tataatgtct 2475301 tcaggctctt ccgtagcgac gccttccttc attgcggttt ttgcaacttc aacagcaacg 2475361 gttgccgaaa cagtgcgcaa atcttcaact tttggaagca tcggcgcccc aggcaccccg 2475421 acattgacca tacctgcgat tgcccgggca catgcttcaa acatgccgtc ggtaattaat 2475481 tttgattttg taacaatcgt tccaagaccg agaccaggga agacaagcgc gttgtttgcc 2475541 tgcccgatat gatacgtaac tccgttatat tcaactggcg ggaacgggct tcctgtcgtg 2475601 atcagcgcac ggccttctgt ccattcgatt aaatcctccg gctttgcttc agaaagagtt 2475661 gtcggatttg acattggcaa aatcgccggc cgtttcacat gtgacgccat ttcttttaca 2475721 atttcttcag tgaaagcgcc ggaaaccgta gatgtgccga tcaggatcgt cggtttcgcc 2475781 tgccgaacca cttcaagaag atcaatgcct ccgccgtctc cgttccgctg ataatccttc 2475841 acttcatcag ccgaacgggc atacggcttt tggaaatcaa gaagctgatc catatcatct 2475901 gttaacagcc cgttcctgtc tatgcaccag aagcgcttgt atgattcttc ttcactcagt 2475961 ccctcgcgca ccaatgcttc ccgcagctgt tcggcaattc cgattcctgc cgttcccgct 2476021 ccgaatataa caactctgtg atctctcagc ggaactttag acgcttttgc acaggataag 2476081 actgcggcca aagaaacagc gccagttcct tggatatcat cattgaaggt acacacttta 2476141 tctttatagc gtttcaaaat gcttcgcgcg tttttcgccc cgaaatcctc ccaatgcagc 2476201 aatgcattcg gaaatgtttc tctcgccagc gcaacgtagt cgtcaataaa ttggtcataa 2476261 cgttccccgc gcactctgga atgctggttg ccgacataaa gcgggtcgtt caagaggctc 2476321 tcctgatttg tccccgcatc taaaacaaca gccagcactc tgctcggatc aatgcccgca 2476381 gccgctgtat aaaccgccag cttgccaata gaaattgcga ttcctccgac gccccagtca 2476441 ccgattccta aaattccttc cgcatcagtt gcaacaatta aatcgatcgt atcgctttga 2476501 tctttatact gtttaaaagc ttctttcata ccgtccgggt catcgattga cagatagagc 2476561 cctcgtggtt ttctgtattc atggctgtat ctctgaattg ccgttccgac tgtcggtgtg 2476621 tagacaatcg ggagcatttc ccctaaatgg tcatttaaca ggcggtaaaa cagcgtttca 2476681 ttccgatcgt gcagcgccgt taaatagaca tttttgctca aatcgtcagg ctgtgcggaa 2476741 tattgttcat acgctctttt cgcctgatca tcaattgtta ataccttggg cggcagaaag 2476801 ccttttaaac caagttcttt tctttcttcc tcagtaaaag caacaccttt gttcaaaaaa 2476861 ggaacagaga gcacttcaag gcctcttaat gttgtttgaa tgtctccttc gtttgttact 2476921 ctgaattgtt tcaccctgcc tcttcctttc tgagcataat agtactaggt ttgcattatt 2476981 agccggaaaa catgcagggt aaacataaaa atatgctatc gcttcattcg cttaactgac 2477041 tttttgatgc ttccgtcctc ctcccattga agggcgcgat actcggcatc atggtaaaaa 2477101 ataaaccaag catctttttc tgctgcgaac gcctgccatt tctgcttttg cgggatagag 2477161 gtcatcggat aatcatcgta agccagcacc catagcggat tgcggtgggc atgtgtcggc 2477221 atcagatctg ccatatgtac ggcagtttca cccgcatcct cgcatatcag gacactgtgt 2477281 ccgtcgctat ggcctccggt gtgatgcatt gtaataccct ctgtgatcgt taaggtgtct 2477341 tcaaaggttt tgacttggcc agctacagcc tcccaatttt ctttccaata cgtatttttc 2477401 gacctgatat tcggatggcg catttcgtcc cattcaacag ctgatgtata aatcactgca 2477461 ttcggaaaga cagagacgag ccgttcacct tcatattccg ttaaaccgca tgcatgatca 2477521 aaatgaaggt gtgtcattgc gatcacatct atatcggcaa ccgttaatcc gagtgcagct 2477581 aatgagggtt tcacattcga ctcttgtgtc acgccatagt ttcgtttttg tttatcagtc 2477641 agcttgccgt acccaattcc ggcgtcaatg atgatattga gcccatcctt ttgaatcaaa 2477701 atagggtctg ttcttagttc aatctggttt ttttcattga ctggatattt tttagaccaa 2477761 agcggctttg gcacaacgcc gaacatggcg cctccgtcca tatgcgtcac gcctccgtca 2477821 agccaggtca acgtgatgtt tccaattttc attgtttcca ttttcacccc cccctatcat 2477881 catggtagca aacggcccat aaaaaaaaca gactcctgtc agagtctgtc tttacgttct 2477941 ccattcaacc tcagcccgat agatcggctg gccgagtgca gagaattttt cttcatattc 2478001 tgtcataata ttgccttcca gattgctgtt atgcaaatcg agactgacgt atgtcagcag 2478061 gaggccgtac tcagagaagc tcttcaaaga gtactcaaat aaacctcggt tgtccgtttt 2478121 aaaatgaatc gatccgcctt tgcccattac ttcttcatat tttttgagga agtgggaata 2478181 tgtcaggcgg cgtttttcat gccgtttctt cggccaagga tcagaaaagt tcaagtagac 2478241 ccgtttcact tcccccggct caaacacatc cgtcagcgtg tccgcatcta tattcagaag 2478301 ctttacattc tgcgcttcgc tgtcttttac tttttggacg gctgtcacga tgacgctttt 2478361 aaataactca ataccaatat aattgatgtc gggattttgt ttggccatac cagaaataaa 2478421 ttggcctttt cctgtaccaa cctcgatatg gatcggattg tcgttgccaa acactgtgtt 2478481 ccatttccct ttataatcag caggattgct gatggcaata tctgcgtttt cagccaaaaa 2478541 gtcatcagcc caaggcttgt ggcgcattct catatgattg acacctctat ctattatttc 2478601 gactaacaac ataccatgaa ttaaaaagac ccgcaagctc gtttttccag tgtatctctc 2478661 ttaaggccga gcgcataaaa aaagagggtc ccgtctgctg gaacactcct ttcccatgta 2478721 taaaaacgct ctgttttgaa caatttaacc cgtatgatac tgaagggatg tgtaccgtta 2478781 tgggtttaca ttatgagcat caagttcatt tattgaagga tatattgact gaccatcaat 2478841 tggactgctg cggaacagtc gcagagtacg agcagcttga gcgtgtgatt aaatcactga 2478901 tggcaaacac cgagcttgat tcaaatttca aaaacgtgct tgaagatgtt taccgctaca 2478961 gccaatcagg aatatcgtcc aaatccatcg actcacacat acaagagcat cagaacagcc 2479021 tgtctcaatg ggtagagcaa atggattcgt attcctgatt aatcaacaat tcgtttcatg 2479081 aggatatgca gctcttccat tgcatcatga aattccttat cattgccttt tgctttatgc 2479141 caggcaatga aagtaattgt ttcagataac acataccaag ccattcgcaa ccgaaggctt 2479201 tctgtcagct ctatgccgta catgctcagc cagctctccc aagctggctt ttcgacgtag 2479261 tggtacagca aaggcccgag gtccatcgcc ggatcagcga tcatggcgcc gtcccagtca 2479321 attaaataca gctggttgtc ttcagacaat agccagttat tatgattgac atcacaatgg 2479381 caaacgactt tctcaccgaa atgcacttca tgcaggtgtt cttccaaata cttgatccct 2479441 tcttgaatca gcggcgaaga ttgctgcaca gcaaatacag cctgcttcag ctgagacaaa 2479501 agagcccccg ggttcagcgg ttcttttcca agtctcttca gcatgtccag caaggctttt 2479561 gatgtgtgta ttttacgaag caattcagca acgggccgtc cgctcatgtc tttaggcttc 2479621 agctctctgc cggtcatcca gtgctgggcc gtaatgacgt ccccattttc catccgtttt 2479681 gtccaaacca gcttcggaac aatgccttcg gcggataaaa cagctaaaaa aggtgagcta 2479741 ttacgtttta aaaaaagctg ctgcccgtta tgtttcgcat aatatgcatc tcctgtagct 2479801 cctccggcgg ggaagatctc ccaatcgcta cctagtaatt gtcccaacca gttcatatca 2479861 atgttcaacc catcatttct taaaatattt tagaattaag gctaatcgtt tctagtctat 2479921 ccagcgaatg cctttttcgt acgaatcgta taaaaataaa aaagacagct attgagagtc 2479981 tcatatgcta atcaatagcc gtcctttaaa ttttagcgct atagcacaaa cttcgtcaag 2480041 caaaactctt aagatctgat gctaaatata agataaccgt tccgatgccg tttactgcaa 2480101 ccgttttctt gatttctgtt gggtcttcct gaaatcctga tggatcacat aaaagccgat 2480161 aaggtatgtc gtttggcagc ctccactcga cggagtctgg actcgcgtga tggataacaa 2480221 tgatatcttt ccattcgtca acctcgtcaa gatcataaag cctgtatgcg ataaggtgtt 2480281 cttttagcgt caagcattca agatggcgct ggatgtctgc agcggaccta agacggaatg 2480341 caggatgcgc ttttctcagc gagatcagcc tgcggatata gtgaacatct tctttgaatg 2480401 tttcacggcg atcccagtcg agctggttga tgctgtcact ggattgatag ctgttttcca 2480461 ctccctgctt cgtccggaaa aattcctggc cgctgtgaat aaacggcacc ccttgggcaa 2480521 gcaaaataat cgcggctgca agcctttgcc tgcttcgctt tcggctgtca ttttcttgag 2480581 gaagcgcaaa gctcatttta tcccaaaagg tgtgattgtc gtgtgattcg acataattga 2480641 tggactggct tggttccgga acaatcggtg ctaatgcctt ccatccggaa gacccggcaa 2480701 ttccatgcat cacagcttgt gctgattcac cgttgccgag cgcaaaccct gttgccttaa 2480761 ggtgaaaggt gttccctttt acagcgtcac gaaacatatc attaaaaaag ccgatgcccg 2480821 gcattcttgg cgcgttcgcc aaagcagctt tctgttcatg cggcagcggt gtagccaggt 2480881 cccacccttc tccaaaaagc aggattccgg gctttgcctt agttgctttc tctttcatat 2480941 aaagcacggt gtcaatatct aaaatcccga ggagatcaaa gcggaagccg tcaacattgt 2481001 attcttcaag ccaatagacc acgcaatccg caatgaattt tcttgccatc cttctttctg 2481061 atgcaatatc attgccaacg ccggtgccgt ttgatggcat cccacattcg tcgtgccgga 2481121 aaaaataacc gggcactgtc ttttcaaagg gggaattctc cctcttatac acatggttaa 2481181 aaacaacatc cagaatgact cgcagaccgt gctgatgcag ggtattgatc atttgtttca 2481241 gctctgtttt tctcgtttga ggatcatgag gatttgaggc atagcttccc tccggggcaa 2481301 agaaatgaag cgggttatat ccccaattgt atgcatcaag cggcttctct tcatcaactc 2481361 cggcaaaatc attcaccggc agaagctcca catgtgtcac accaagctct tttacatacg 2481421 ctaatcccga agaactgcca tttgcggttt gtgtatcagt ttccgtcagc gctaagtatt 2481481 ttcccttgtt tatcatgccg ctgttttcat ggatggagaa gtcgcgaaga tgcgtctcat 2481541 agatgacggc atccacaggg tgtgagaatg gtttaagagg agcagtccat ttcatttgat 2481601 ccgggcgcaa gacgacgccc ttctctccat ttacagtcac agccttggca tactggtcaa 2481661 ctgtttccat ccattctgaa ttgttgcaga tgcaaaacaa atactcatat ccgtgaaggt 2481721 cacctgtgac cgtgacggca tagacgcctt tttccaagcg agtcatttgg aatgtgcgcc 2481781 cgcttttatt ggggtgtgaa agcttgacag cagctgaggt tgcagcaggc gcccatactt 2481841 taaatacggt atgatccgcg gtataaacgg cgcccagctc tccgtcataa taaaattcgt 2481901 catcaaacgc tgccgtccgg atgaccgcgc caatttggag atccgttttg tggccgctgg 2481961 atgctctgac gcaatggatt tttccaaatg tcacaggatg gtcggatacg cagacgtact 2482021 tgtattttgc ttcaagggag tattcctccc tgacagccag aggaaaatct gttatttctg 2482081 tctcaagccg aaacggcggt gtcatgattt ccttttgttc agcaggaatc agaacagtaa 2482141 tgatattcat gtcatcgaca tacgcttcga agctgcggcg gatgctgacc atcggaagct 2482201 ctctcctcca aacacgttta tgttttgatt cttaggggtg aaggactaga tgccagacga 2482261 aacggggtag tgcccatgat ttctccgtca gcatggaacg ggattttgtc cttcgtgtaa 2482321 aatgtaatgt ccttcgcttt aaacatcgta acgccatcca tctttgtatg ttttccaaat 2482381 gccatgagac ataaaagcca atattttttc aaaaacggct ggttttcaac gattacgata 2482441 tcaaatgtct tctcgcgcgg atttgctagg ggcgccgcct tcatgcctcc cccgtaaaac 2482501 ggatggttgg atacaacggc aaaccagaca tcatgaaatt cgcgcgtctc gtcttccgtc 2482561 gtacaagcta atgtaaacgg cttaaaggtt gccgaagcgt gcaaatgaga aagcggatac 2482621 acaagaaatc gaaggcggag aaaaagaaaa acccgtctca acggaaattc catcgccttt 2482681 ttattgacat atgcgtcaaa cccgatcccg atatgattca taaaataaag aatctgtgat 2482741 ttatcctgaa ggaaattgac gctccctaaa tgaaaggttc ttgttaacgg gcgctttacc 2482801 ttcttgattt cctgtatcag atcgattttt ttaatagaga accctcgcga aaaatcatta 2482861 tacgcgcccg ccggcacaaa gctcagctca atatcgtcaa catctttcag cccgttgaca 2482921 acttcatgca tggttccgtc tccgccaatg acgatcaggc gcttcagctt atattcctgt 2482981 atcgttgaaa tctgtctggc gagcacctcg gcgtgtcccg gatgttcagt taaaaatgaa 2483041 cggtgctcaa cctttcgttt gatcaattct ttttgaatgg acttccaaac acgcaggccg 2483101 tttcgatgtc ctgctgtcgg attaataata aaaaaccaat ggctcatctt tctcacctgc 2483161 ttatgttatg agaaaaccgc tcaaatcgtt ctcttttact ccagccactc ctgtctgcga 2483221 taggagtcag acatgcagta agacaataga gcctttgcag cctttacctg atgatgtttg 2483281 atcggagcag tgtttttctt ctgccgctca atccattctt ccgcgctccg cttatccgct 2483341 atttctaagc cgtatggcgg ctccgggtaa tcgatgtacg acgttctgct cagaagcaat 2483401 tttcgaaccg gaatctcagc ctgtttttcc tttacgatct ttgacacaac cgagtccgta 2483461 cgaaacaggc taagccctgg atttaacact gatgcagtct gagaggctgt tttcttgtcc 2483521 caaaaacgat ttttagaccc tatgtagaca ctgtcttcct cagcctctaa aaaagaaacg 2483581 caataaattt ccagaggaga aataatcaca atgcttaatt caaccgccgc ctgctgaatt 2483641 ttcagcacag gcttatacat aataaaataa gaatcaggca gctgctgggt cagataacgc 2483701 aaaatgcggt cctgcttcac ttggtttgag agttgagata tttctgaaag agtagagctt 2483761 gcccatttga gctgaaaatc atataaatgc cttttataaa aagaagcaag cgccaccctg 2483821 ctcttcggga gccttacatg aatatcttct tcgtcctcaa accattggtg tctctcttct 2483881 tgtatatcgg cttttatctc ttcttttctt cttttcaatg aaaatttttt tcgtttctgc 2483941 accggttccg gttcttcagc actggcttgc ctttcttcat gctggcgctc cgctgcttct 2484001 actagtgaaa gccagcgctc ttttttcaaa cgtacaaact ggttgatata atggtacgga 2484061 tcaagctcat atctcgatat ataatcatga attttgatga tttgtgccat gtttgtttct 2484121 ccactccgca atgaattaag ataattgaaa tttgaatatt tcctcgtatt ttggtgattg 2484181 gttcaagtgt atttgaaaga gcgaaaatcg ttcagccatc atcgaaacct cgccgctttc 2484241 aaacggaaca tgagctggaa atccatcttc gcctgtccat tttcttgcca gcgtcatatg 2484301 aggatgatac ggtctttttt ccacttgaaa gccggcctga agtacagcct gcttcgtatg 2484361 ttcccgcagt ctatcaagcg ttttgttttt ctttggctcc agatgtaaaa cgcgcggctt 2484421 tctgcggtcg ccgaatacat ctatcttgcc aaacttaatt gaaaatggat caatttctga 2484481 agcaatctct gctagcgaac cttcaagctt ctttatttgt gtctcatccg ccgctccgag 2484541 aaaaattaac gtgatatgat agtcaagcgg gtgcacccat ttttgaaacg tcaatatcgg 2484601 ttcgtttttc gcagcctggt agatcggatt tgcaattccc tcaggtatgg gaacgccgat 2484661 gaaataatga ggccgtatat ctggcatccg tctgacactc ccttctttga cagctattat 2484721 tttatcaata aagaggctgt gcggatagag gaacagtgta tgaaaacact ctcgcacaaa 2484781 cgtttattat gttaggatat tatatgacac ttgttttatt cagaaaggaa tgacaatgtt 2484841 gaaaatcgtt gcaaacacag ctgatctgat aggagataca ccgctagtga gattgaatcg 2484901 gcttcagccg gaaaatgcgg cacaagtcta tttaaagctt gaatttttca atccgagcgg 2484961 cagtgtgaaa gacagagccg cttatcaaat gatcatagaa gctgaacaaa acggtttact 2485021 caagccggga tcagttatta tagagccgac aagcggaaat accggcatcg ggctcgccat 2485081 gaatgcggca gcacgcggat ataaagcaat cttagttatg cctgatacga tgacgaagga 2485141 acggatcaac ctacttaaag cttacggtgc agaggttgta ttaactcccg gagaggaaag 2485201 aatgccgggc agcatcaaaa aagcgaagga gcttgccgaa caaattccga acagctatat 2485261 tccaatgcag ttcgataaca ctgctaatcc tgatgcgcac cgaaaaacaa cagcgcctga 2485321 aatcgcccgg gcaatagagg aaatcggaaa accgctcggc gcttttgtag cctcctctgg 2485381 aacgggcgga accattaccg gaacaggtga ggcgctcaaa gagctttttc cggatatcac 2485441 ggttcatgtt gttgagccag cgggttcgcc tgtattatcc ggcggaaaac ctggcgcgca 2485501 taaacttgta ggaacgagcc caggctttat accgccgatt ttaaatgaag acgtttatga 2485561 tgaaattatc aaaatctctg atgaagacgc gtatacgacg acaagacggc ttgctgctga 2485621 agaaggaatt cttgtcggtc cttcatcagg cgctgcctgc ttcgcggcaa tcgaaacagc 2485681 gaaacgcctc tctcctgaca aagttgtggt ctgcatgaca gctgatacag gagaacggta 2485741 cttatcaact gatttatggt catttattta aaaaaaggac tggcttcagc agaagccggt 2485801 ccttttattt tgcaagctcg taaatggcct gagcatataa cgctgtcgat ctcagcaggt 2485861 catcaatttc gatatattca tccttttggt gtgcgctgtc agggcgtccg gggaacagcg 2485921 ggccgaacgc gacaccggct tttaaggatc tcgcataagt ccccccgccg attgagatta 2485981 aatcagcttt tttacccagc tggccttcat aaaccttttg cagggttttg actaacggat 2486041 gatctgcgga cacgtgatgc ggcttgctgt ctttgaattc tcccagctca aattcagatg 2486101 cgctttcgaa tgtatcgcgg atcactttgc tttctgctgt cacaggatag cggatattga 2486161 tcccgagctc gcctccttgc ccttctttat agcgcagtgt tccgacattt aatgtcagct 2486221 ctccgctgat ttcatcctca cagtcgatgt ccagtttttt tcctcttgta tcacctgaga 2486281 acttatctgt cacaacttgc acaaaccgct ttcctgcatc gtcaagctca gtctgctgga 2486341 gaaattcgca caataaaatg ccggcattga tcccattgtt cggttccatc gcatggcagg 2486401 aaagaccgta catacgcaaa atgagctgtc cgttctctat tgcagcttcc cctttttggt 2486461 ccgtcgtgcg gagcatgtct ttaaatgaag acagaatctc ttcatttttc ggcccttcaa 2486521 tgacagcttc cgcagcgtcg ggcaccatgt ttaagcgaag gcctgattga aacgagacaa 2486581 gcactgcctt tggttcagct tgatttgggc ggtgcggaat aagtaaagaa gcatcgatga 2486641 tccctttttc cgcattaatg atcggaaaat cggcgtcagg cgcaaagccc attgttggca 2486701 tttcttcatg cttgaaataa tgctctacgc atctccaatc actttcttca tctgttccga 2486761 taatcattct gactcgcttg gacaggggca aattcatgtc tttcacgatt ttcagcgcgt 2486821 agaatgccgc cattgtcggg cctttgtcat caatggcgcc ccttgcataa atccgtccgt 2486881 tgcggatttc agctgaaaat ggatcactcg tccacccatc tcccggcggc acgacgtcaa 2486941 catggcaaag tacgccgata atgtcatcgc cctcccccca ttcaatatga cctgcgaagc 2487001 cgtcaagatt ttttgttgta aagccttctt tttctccaag ctccagcaat gaagtcaggc 2487061 tggcatttac cccttctcca aacggtttac cgggtccggc ggttgtttcg tccatgacac 2487121 tgttgattct caaaaattcc tgtgtatcac gaattaaatc ctcttttttt ctgatcactt 2487181 caacttccca gttcataatg atcccctttc cgcaagaaat gacttgcaaa aaccaaataa 2487241 aacgaataat attaatggtg ttttgttaaa acgttcgtaa ttggaggata ctatgtttca 2487301 tctaaaagag cagcaaacat ccataaagca agaaatcata gcagggctga cgaccttttt 2487361 cacaatggtc tatatcgtcg tggtcaatcc ggtcattctg gctaacgccg gggttccttt 2487421 cgaccaggtt ttcaccgcaa cgattattgc ctccattgtc ggaacgctgt ggatggccct 2487481 ggcagcaaat tatccgattg ctattgcgcc cggcatgggc ttgaacgctt atttagcctt 2487541 tcatgtcgta agcgcaagcg atggcggcat cacgtacgca acagctttca gcgcagtatt 2487601 tacagcaggg gttctcttca ttattctatc gttaacgcct ttaagaaaac aacttataga 2487661 agcgattcca aacaatttaa aatacgggat cacaacaggg atcgggctgt ttattgcttt 2487721 tatcggtttg cgtcaagcgg gaattgtggc agctgatgag tcaaacctgg tcactctcgg 2487781 caatctgcat tcacctggtg ttatcttaac gctggtcggc cttttgatca gcgtggtcct 2487841 gatggtgctg aatgtaagcg gcgctttatt tatcggaatg gcagctaccg ctttgatcgc 2487901 ctttttcacc ggtcagctcc atttttcaaa gggatttatg tcgcttcctc atttgccgga 2487961 aggattgatg atctcaaatc catttaccgc ttttggcgat gtcattcatc acggcctgta 2488021 cgctgtcgtc ttttcttttc tattagtcac catttttgat acgacaggca cgatgatcgg 2488081 agttgccgag caagccgggc tgatgaaaaa caacaagctg ccgaacgtgc gaaaagcgct 2488141 gcttgctgat tcaaccgcga cgacagtagg agctgttttc ggcacaagtc cgacgactgc 2488201 atttatcgag tcttccgccg gtgtcgcagc cgggggaaga acggggctta cggctttgac 2488261 tgtcgcggtg atgtttgcgg cttcaatgtt tttcagtccg cttgtcagcg ccttgtcagg 2488321 tatagccgcc atcacctcgc ctgctttgat tatcgtcggc agcctgatga tgggctcagt 2488381 ttccaatatg aactggaaag agatggacga ggcatttcct gcgtttctcg tcattctagc 2488441 catgcctttg acctcgagca tttctacagg aatcgcgctt ggctttattt cgtacccaat 2488501 tgtaaaagcg gcgcggggaa aatggagaga gattcatccg ctcgtcatcg ttttcgccat 2488561 tctgtttttc atccagctgt ttattttata aggatagacc aaaaaaccca aacgtcgccg 2488621 tttgggtttt ttatgtaaac aataaagaga cagcggccgc taaaaaacaa caggcggcaa 2488681 acgcatagtg caggatgttg atacagcttt ttctggcccg ataatattca tcactttcct 2488741 tatcggtgcc aattaaaaaa ggggcatcca tgaccttgtc aaaaataagc gtcaggatat 2488801 aacggcaaac ccctgtgtat accagcagcg caatcacctt cagccaaatt ggggaaacaa 2488861 atatgagaac agtgaaagct gacagtagca tgtacatctg ccttgcatac tcgccattcc 2488921 tcagcataac tttaaaaaac aactccttat agcctgtgca gatcgttcgt cttttaaata 2488981 tcctttttga atttcggtat aataatggtt ttcttctcat cctgtctttt acttttggca 2489041 ttcccgcctc ctgactcatc atcatcacaa gtcctgcaag ggcaagcctg ctttttttct 2489101 cttcagtcac ctcagcttca aaagccgtga acgaggctgt ctttttcaaa ctgcggataa 2489161 ctgagaaaaa caaaaataaa atgccaaaaa gcgcaagcaa gtgccgctca gtaaaaacaa 2489221 tcaggatagc agaaccagca aaaagaatag ctctgacaag ggtatcgcca atccatctcg 2489281 aaatggagcg cggctttctg atcctgtctt gctttaagga taaaaagaat atatgaaggc 2489341 caaacaaata acacaataga gcagtgcttt ctgcgaatgt gatgagaaca gaatgactga 2489401 tcaagggaag gacaatgaaa aagagaagca gccatttagc cagcgtggcc agaaaagaat 2489461 acaaaagcgc ataccgtttg agctgataga tgatttcctt cttttgcagc aaaaacactt 2489521 tgtccgcttc cattaaaaat gtacgaatcg aacctgtaaa catgatcagc acacacacag 2489581 catacagcca tctccattcc gccacttcag accactcata aagaaggcct cttccgttca 2489641 tcaaatcaat atactgatag atgacaaaag caatcgccgg caaaacgata tagagagcga 2489701 ctgtccagtc aatgaccgca tgcaacactt taaactgata cttataatag tcaaacagcc 2489761 ttcgaaaaaa gagcgtacgc ccgttcatag ccgatcacct tgaactgcct tataaaaaca 2489821 gtcaagcaat gactgcccct ctaatccggt cttgtcctga acatctttta acgtgccttg 2489881 gagaaataat gaacctttct caatcatata aaaccggtca cagatttttt ccgcggtatc 2489941 gagtacatgc gtgcacataa gaattccggc tccacgttct ttttcagcct taagcatgtc 2490001 cacaaagcgt ttcgtcgata tcggatcaag gccgataaac ggttcatcaa tcacatacat 2490061 atccggctta gagagaaagg cctggataag cattagtttt tgctgcatgc ccttcgaaaa 2490121 ggtgacaggc agctcatgtt tgacatgatc tagcgaaaac gtctgcagca ggctttgggc 2490181 ccgatgcgca aattcactct cttcaatgcc gtgaagtgtg ctgatcagat ccaaatgctc 2490241 ccacagcgtc agttcttcgt agaaggacgg atgctccgga atatatgcaa atgaacagtc 2490301 gttccaggca atatgccctt taaaatcttc tgaaaggccg agtatcgcct tgattgcggt 2490361 gctttttcct gcgccgttag ctccgatcag tccaaccagt tccccttttc tgacttccag 2490421 aaaaacatcg gtgagcactt tttttcggct tgtatacccg gcctgttcta ttgaagcttc 2490481 aagcaaattt gtcaaaactc actcacctcc aaaatttact acgaaataga ataaaaaaag 2490541 tttctttaac cataataata ttgagccgaa atacatagta atccaacaag gatggctgcc 2490601 caacgcgaaa ttggaaaaaa ttaataggag ttatccctag attcatcact gcaatatcgt 2490661 gtataatgag ggcgaattat tttaacaatt acagatgtct gcctttgttg ctatttcgta 2490721 cgcagttgat agtcgtgagt tgtggttagt caagtccatc cgatcttatg atagggagtg 2490781 gttttttgaa accttcaaca aaccgtatgc taactcgaat caaatcagtt tacatgttta 2490841 ttcaagaaaa aggtcttgtg acaacacagg aactggttga cgaattcggc attacaccta 2490901 gaacgattca aagagactta aatgtgttgg catataatga tcttgttcat agtccaagcc 2490961 gtggcaagtg ggagacaacg agaaagaaag taaagattac ctcataaatt gaaaattaca 2491021 tagggccgcc tgagagcggt ccgatagata acagggcgaa gaaactactg agccttgttt 2491081 ttgtgtgctt ataaataaaa ccccgcattc ggtatgcggg gtttttgtca tgcttgcggc 2491141 tcatttagca aatgaagctc ttcctctgtc agctcacggt attctccggg tgccagagcg 2491201 ggatctaggg aaacgcgtcc catcgaaagc cgcttcagat aaaccacttc attgccgact 2491261 gcctttgcca tttgcttgac ctgatggtat tttccttctg taattgtcag atatataacg 2491321 gtattgccac tgtcgtttgt tttgatttcc gcttttgccg gctttgtttt atagccgccc 2491381 tctatgtaga cacccgtttc caaatcggaa atgtcttccc gagaaatctg tgattttaaa 2491441 tggacttcat acgtttttgg aacatgcttt ttaggagaaa ggagccgatg tgcgagctgg 2491501 ccgtcatttg tgagcagcaa aaagccctct gtatctttat caagcctgcc ggctggaaat 2491561 ggctcaaatc tcatctcctc cggcgtcagc agatcgacca ctgtttgctg ccggctgtcc 2491621 tcagtcgccg acagcacgcc ctgcggttta ttcatcataa gataaatgaa ctctcgataa 2491681 tcaaccggtt ccccgtatac ggtcacctcc tgcgtatcag gatcaacgtg ctcctttaca 2491741 tctttggcag gtttgccgtc gatcatcacg gctccagcct tcacaacggc tttgacttct 2491801 tttctggaac catacccgct gttggcaagc agcttatcaa gtctcattcc caatctctcc 2491861 tttataaaag aaagcccgca gcatgcgagc cctcagtttc atcatatcta gttcatcagc 2491921 ctgcatgtct gcctttccta aagaaacctg gcaaacggcg gcctaaaatt ttctgcaaaa 2491981 atcctaatcg gtagccgcaa tacaggtaga cagctccgcc aacagcggcc gcgatcacca 2492041 caacaatcgc agcttgcatc tggccatcct gataggaaat aaagaagcct aatacccact 2492101 gcacgatttt cacggcaata cccataatgg ctgataagac cagcatcaaa acagttcgtt 2492161 taacaagtat cttatacgaa tagcctgcat ggcgcttaat catgataaac ccatataaaa 2492221 gggaagcgat atatccaagc gccgtcgcta aaatcgctcc gtcagcctgc atcagcttga 2492281 tcagcggaac attcagcaca agcttgatca cgacaccgat cacaaggctg acaaccgcaa 2492341 atttttgctt attgatgccc tgcagaatag ctgcgttgac tgtaaacaaa gagaacagaa 2492401 ttgcgacagg cgaataccaa agcaaaatgt ttgcccccag ttcaggatga aggctctctg 2492461 acccgtaaaa gaacgtatac gtcggtcctg acaatagaga gatcccgaca acagccggaa 2492521 taattaaaaa caggatcgtc tgcatcgttt gattaatctg ctgatttaac agcttatagt 2492581 ttccgcttgt aaacgattca gtaatcgttg gaattaatgt cagtccaaaa gcagttgcta 2492641 gggaaaccgg gatcatcacg agcttctgaa catacagggt tagaatcgca agcatgtcct 2492701 ggctgatggc ttgatgaccg gcttcaatca tcgctttgtt aaacgtattt gtatcaatat 2492761 agttatacaa agggatggct agtccgacaa aaacgtacgg agcagcatag ctgaacagct 2492821 cgaaaaacat tttcttgtag cttaggtttg ctgtcggacc cgtattcggc atcatcgcca 2492881 gcaggctgcc cttccgtttg ttccaataaa tataaagcac gaccagccct ccgaaggcac 2492941 cgatcagcgc tgcgaaggtt gcatagccca cagcgatgac aaggccgccg ttgaaaacct 2493001 tcaaaatcaa gaatgtcgca ctcaatagaa agatgatgcg gacaatctgt tcaacgactt 2493061 gggaaacagc tgtcggaccc atcatttggt gcccttgaaa gaatccgcgg acaaggctca 2493121 taatcggtac gaccaaaagc gctaagctga ccatgcggat gacataaacg acatgatcaa 2493181 ttgtcaggcc gttattatcc ttgcctccca gcgatatttc cgcaaacatc ggagccgata 2493241 gatacagaat gaaaaaggct atcattcctg tgactagcat aaccgacatg cccgccttga 2493301 gcattttcct gcttgtctca taatcccctt ttgaattata tttggaaaca aatttagaaa 2493361 cagcggccgg aaagcccatc gtagcaatat tcaaaaataa agtgtattgg ttgtatccgt 2493421 attgaaataa tgcaccgcct gtcgccccga ccataatgct gaagggaatt aaatagacca 2493481 tccccagaat ccgcgatata tatgtaccga gcgttaatac aaacgtgcct cttaacagtt 2493541 tgcttgacat gtttcttcat caccattttc tacgaagatt caacttttct attttaccac 2493601 aactgggcat ttagacggta ataaatacaa aagcaatcct gtgaacattc atgtccgcgg 2493661 caaaagacgt ttaaggagcg gctttctttc gctataatag tactgcggac gggtgtccgc 2493721 acacgaaatg aaaagaaagt tgatgataaa gatgaaacaa tatgacgtaa tcgtaatcgg 2493781 cggaggccct tcaggcttga tggctgcgat tgcagcagga gaacagggcg ctggcgtgtt 2493841 gctgatagat aaaggaaata aattaggacg gaaactcgcg atttccgggg gcggccgctg 2493901 caatgtgacg aaccgccttc ctgtggaaga aattatcaag cacatccccg gcaacgggcg 2493961 ttttttatac agcgcgtttt ctgaatttaa taatgaggac attatcaagt tttttgaaaa 2494021 cctcggcatt caattgaagg aagaggatca cggccggatg tttcctgtga ccgacaaagc 2494081 ccaaagtgtc gttgacgcgc tgttaaacag gctaaagcag ctccgcgtaa caatcagaac 2494141 gaacgagaaa attaaatctg ttttatatga agatggacag gcagcaggga ttgtgacgaa 2494201 taatggcgaa atgatccata gccaggcagt cattattgct gtcggcggta aaagcgtgcc 2494261 tcataccgga agcacgggag acggctatga atgggctgaa gccgcgggcc ataccataac 2494321 agagctgttt ccgacagagg ttcccgtcac ttctggcgaa ccgttcatta agcaaaaaac 2494381 acttcagggc ttatcactaa gagatgtagc cgtcagtgtg ttaaataaaa aaggcaaacc 2494441 gattatcaca cataaaatgg acatgctgtt tacccatttc ggcctctcag gacctgccat 2494501 tctcagatgc agccaatttg tcgtaaaaga gctgaaaaaa cagcctcaag tgccgatcag 2494561 aatcgacttg tatccggata tcaatgaaga aacgcttttc caaaagatgt ataaagaact 2494621 gaaggaagca ccgaaaaaaa ccattaaaaa cgtgctgaag ccttggatgc aggagcgcta 2494681 tctcctattc ctgctcgaaa aaaacggcat ctctccgaac gtatcgtttt ctgagctgcc 2494741 gaaggatcct ttcagacaat ttgtaaggga ctgcaagcag tttactgtcc tcgcaaatgg 2494801 cacactgtcg cttgataagg catttgtcac gggaggcggg gtatctgtaa aagaaattga 2494861 cccgaaaaag atggcttcta aaaaaatgga ggggctttat ttttgcggtg aaattctgga 2494921 tatccacggc tacacaggcg gatacaatat tacctccgcc cttgtcacag gcaggcttgc 2494981 agggctaaat gccgggcaat acgcccgttc ttaatcatta ctctttaaat ctcttgccgc 2495041 caaactcaca tttgaacatt ccccgcattc atgttagggt gagacttgtt ttgtttcacc 2495101 tgattgcggg gtaattttaa gagaggaatg agctgccatc gtacgaccat actaagcctg 2495161 cgagcaagat ataggcgtac acaaaaaatt agagggtgag aaatgttgaa acatatatct 2495221 agtgtatttt ggattgtgat tgcaatcaca gctgcagctg tattatgggg tgttatttct 2495281 cctgacagcc tgcaaaatgt gtctcaatcg gcacaagcat ttattaccga ttcatttggt 2495341 tggtattatc ttttagttgt ctctttgttt gtcgggtttt gtctcttttt gattttcagc 2495401 ccgatcggaa aaatcaaact cggaaagcct gatgaaaaac cggaattcgg gttattatca 2495461 tggtttgcca tgctgttcag cgcaggcatg ggaatcggct tagtattcta cggtgcggct 2495521 gaaccgatca gccattacgc aattagctct ccatcaggtg aaacagaaac cccccaagcc 2495581 ttcagagatg cactccgcta tacgtttttc cactggggtt tgcacgcttg ggccatttat 2495641 gccattgtgg cattatgcat tgcctatttc caattccgca aaggcgcacc cgggttaatc 2495701 agcagcacac tgtcaccgat tctcggggat aaagtaaacg gaccgatcgg aaaggccatt 2495761 gactgtattg cagttttcgc cactgttgtc ggggtgtcaa caagtcttgg tcttggcgca 2495821 acccaaatta acggcggttt gaattacctg ttcggcattc cgaatgcgtt tatcgtccaa 2495881 ttggttttaa tcattattgt gacagtgctc tttttacttt ctgcgtggag cggactcgga 2495941 aaaggaatta agtatttaag caacacaaac atggtattgg ccggattgtt aatgttgttt 2496001 atgctcgttg tcgggcctac agtgctgata atgaactcat ttacagattc tatcggacaa 2496061 tacattcaaa atatcgttca aatgagcttc agactgacac cgaacgatcc tgaaaaacgc 2496121 gaatggatta acagctggac gattttctat tgggcatggt ggatttcctg gtctccattt 2496181 gtcggcattt tcatcgcccg tgtatccaga ggccggacga tccgcgaatt tttaatcggc 2496241 gtcttggtga caccttgtat tttgacattt ctatggttct ccattttcgg cgtatcagcc 2496301 atggatctcc agcaaaaagg cgcgttcaat gtagcaaagc tgtccactga aacgatgctg 2496361 ttcggaacac ttgatcacta tccgctgaca atggtgacat cgatccttgc attgattctg 2496421 atcgcagtat tctttatcac gtcagctgat tcagctacat tcgtgctggg catgcagacg 2496481 tcgtacggtt ctttaaatcc ggcgaattct gtgaaactca gctggggtat cattcagtcc 2496541 gccatggcgg ctgtgctcct atattccgga gggcttgccg ctttgcagaa cacagcgatt 2496601 ctggcagcgc tgccgttttc tatcgttatc ctgctgatga ttgcctctct ctatcaatcg 2496661 ctctcaaaag aaagaagaga gatcaaaaaa gcggagaaac tcgataaacc aagaagtcca 2496721 agagtgaaaa aagcatatta acaaaaaaga tctttccgcg cctgcggaaa gatcttttta 2496781 tttgcgatat aaaataaggg cggaaaaaca gtaaagctgc tcgccgtctg ggtcgcacgc 2496841 cgccgaaacc gtatatttga tatctatcag ctgctcctcc gatatccctt ttaaaaatga 2496901 attgatttcc gtttgtaagt ctttttcatg ctcttcatca aataccgcta ccttcagcat 2496961 tttatccgct ctcctttctc tatcaatcta ttccgtttgg aacagcgtta tgatagagaa 2497021 atgatgatta tctcgtttcc ggataaaaag ctttccgtat atgggatttc ctctgtggct 2497081 cgccgccgtg ctgctccact ttcagcagca cggcataaac aatgcgcata tggcagtagc 2497141 tgataaggct gacgctgaaa aaagggacaa tgcccggcag gtacgcaagc aagaaaaaga 2497201 gagcaacagt cagcgcaagc atagtaagcg tatattgcaa atacgccaca ctgagcaaga 2497261 gcgaaaattt cacatacaga cgttttttcc agtcaaaatg gacaagcagc ggaaacacat 2497321 aaaaaagcat ggatacgaac aaaaagccaa atatcataat ggcgaagcgc aggatgtgca 2497381 gaaggaaatg acttggataa attaaggcca aatcaatata aatgatcact ccgatgagcg 2497441 ccagtacagc gccgagcaga tttgaacgaa aaaattcacc cttgtattcc tgccaaaacg 2497501 ttttgagcac cggaacgttg tcctgcccct ggatccactt ccgcatgaca gcgaataaag 2497561 ccgcggtcgc gggcatgatg ccaaacacgc cgagaccgag caacgtaaaa aacagccaca 2497621 gcaagtttgt atacgcaaat ctcataatcc attcgcaaaa acgcagcatc cgtcccagtg 2497681 agccatcatg ttccatggcg ccccctcctt ttttgcatta tacattctgc atctgaaaaa 2497741 gctctttcat gccgatcggc ttcttttcgg caaccgagcg ccacattccc tcaccaaccg 2497801 cgatggagta ggctccagct tcagccccgg ctaaaatatc atagcggcgc agcgggtctt 2497861 tccctaaaaa aagatcctca agcaaaagcg gatcacctcc gccatgcccc ccttcatttt 2497921 tgaccacttg tatcgtctgc tttgattcaa aaagcggata gtattcgatt gtctgctcag 2497981 gaaaagcaaa cggaattctg gaaggttcgt gaaattcatt tgattcaata cgtccttttg 2498041 tgccgttgat cgtcagccgg tagccttcat acggggccga aaaaataatc gagtagctta 2498101 acagtgcgcc gccatcatat ttgactgccg ccacgtacgt atcctcgatg tcaatttcct 2498161 cgtcaaaaat acacgcgtca ggcctgtatg cagtatataa gctggactgg tctcctgctt 2498221 caagatgatc atcctttata gaagctttag aggaacgggg atgccacctt gaatagtagt 2498281 ggcatttttc tttaacacgg cacgtcccgc aaaaacgccc gtcttcttcc ggcaaggggt 2498341 tccactcact gtccggccca tagtaattca aggcgccata agcaaatacc tcttccggat 2498401 tttgcccgag ccaccaattg acgagatcga agtgatgtgt tgatttatgg acagaaagac 2498461 cgccggaaaa ctgtctcgac ctgttccagc gtttaaaata gctggcgcca tgatacgtat 2498521 caatatacca atttaaatca acagaagtga ccctgcctat ttttccgtcc agaatcattt 2498581 cttttatttt ccgatgaaac gggctgtagc gatagttaaa cgcgacggtg acttttcctt 2498641 cgcttttggc ctccgcttca agcacccgat tcgcatcctg cactgttgtc accattggtt 2498701 tttcagtaat cacatctgta ttccactgaa ggctttttac aatatatgcg acatgcgtat 2498761 cgtccctgcc tgccacaatg acgatatcag gctttgagac gcgcatcatc tcgtcaaaag 2498821 catcttcgct aaactcaggc acgtgggcca gctcgggaaa tttcttcttg caaacggcaa 2498881 aacgtttcgg atcggcatcc agcaatcccg taatctcata atgagttgaa aaccgctcca 2498941 tcagtggttt gataaacata ctgaatgctc tgctgctcaa tccgcaaaag acgatgttct 2499001 tcaatatcct cacctctatc gggcttcagt tagttgagaa atcagctgca gcgcttcctc 2499061 tgttttttca gcatacacag ggataaacgc cgccatatcg cgattcaatt gaaaagaata 2499121 gccgttcagc tgttttttcc ctttttcgat ctgaacggca tagatcgttt tttctcctgt 2499181 ttttttatta acagttgtat aaggagatgt tttttcagga ggcaatccgt ttaacggctg 2499241 aaaattttcc ggatcatcgt aagcttgaaa catgtcttca ggcacgatga aaacatctcc 2499301 ctcatgggcg gtaatttcag tcagcagttt ttcctgaaaa gctggaaaga tatcgacctt 2499361 cccggcattc tgctcggcgg ccttttttat tttttcctgt acgccagcct gcatatcaga 2499421 aaagagaatg acatgcattc cgtccggcct gcttgagcat gatgccaaaa agagcactga 2499481 gacgatcaca cacaaagccg tacgtatcct ttttgtcatt tccccgctga cctaaaaaga 2499541 ggctccagct ctgtcatagc taaaataaac gcgccggctc cgtgcagatc gtttgtgctt 2499601 ctttcgcggc tgacataata gtcatagaaa ccggctgacg ttccgacaca tatgtctttg 2499661 acgagaaacg ctccgtcttc tgatgtttcg gttttatgct gaatcaagcc ttgatacgct 2499721 tttagcagtg ttgtttcgta agctctgtct agatagcctt tattgattcc ttttgcgatt 2499781 gcgtacatgt acagacagga tcctgagctt tccagccagt tatcagacct gtctccctta 2499841 tcaacgatct ggtaccataa ccccgtctct ttgtcttgat agcgacagat gcttttaatc 2499901 atgtcctgca gcgtgttttt ccacacatga cggttcggat gcttcttcgg cagctcttca 2499961 atcatgtcag caagagacat gacgtaccag ccgatggaac gtgcccaaaa ttccggtgaa 2500021 cagcctgtct cttcattggc ccaaggcatt tttttcgctt catcccaggc gtgataaaaa 2500081 agtccggttt ttgcatcctt cgtatgcttt ctcatcaatg actcctgaag cacaacctga 2500141 tcaaacagct ccgtctcctg cttcagattg gcatatttca gtgcaaacgg cccccccatg 2500201 tataagccgt caagccacat ttggtaagga taaccgtctt tgtgccaaaa accgccctca 2500261 gacgtccggt tcagtgttcc atataagctg cgcagccttt ttgccgcttt gacataccgt 2500321 tcatccttcg tctgctcgta taatggaaaa agaatgagac ctgcttgaat ggcgtccagt 2500381 tcatctcttc taaataatag attgccatta tcatcgatta agagatctgc ataagccttc 2500441 gcatactcaa aataccgctt ttccccggtt gcttcccaca gccgcaatac accgcataag 2500501 aaaacaccct gatggtagtg ccagcggttt gcaggtggca gctcctcgac tgtgtacgtg 2500561 ttcataatgg tgtttgccaa tgcctccgcg tacgtaagag gcgattttac agcgattgat 2500621 tgatccattg atcccatccc tttcctaata aattccttcc tcgccaaatt tcttcgccaa 2500681 acgattcgct agcatgacca aaatcagccc gaccgccgct ttaaatacgc cgactgctgt 2500741 actgtagctg aattggccct gtttcagccc tgcagtataa acatacgtat caaaaatttc 2500801 cgccacttcc ctgttagtcg catttaacag caaatacaca tgctcgaagc caagctccag 2500861 cgtgtctccg attttcaaaa tcagcaaaac gacgataacg cttttaatgg cgggcagcgt 2500921 aatatgccac atttgccgca gccgtcccgc tccgtccatt ttcgccgctt catacagctg 2500981 ggggtcaacc gctgtaatgg ccgccagata aatgatcgtc gaccagcccg cttccctcca 2501041 gataacctgc agaatataca ggggccggaa ccattcttcg ttcagcagaa aattgatttt 2501101 ttcaccgcca aaaaacacaa tcagttcatt aatcaagcct ccgtctaccg ttaaaagcac 2501161 aaacgaaagc gatacaacaa tgacccaaga cataaaatgc gggatataaa tcagcgtctg 2501221 aacaaatttt ttaaagagag caatccgcac ttcgttcaat agaagcgcca gcagtatcgg 2501281 caccgggaaa aatatggcca ggttcaaagc aaataacacg agcgtgtttt ttaacaagag 2501341 aaaaaatgta ggctcagtaa acagcctgat aaaatgcttc agccccaccc actcactgcc 2501401 caaaatgccg aggaacggct gataatcctg aaacgcaatc acaattcccc acatcgggac 2501461 atacttaaaa agcaaaaaat aaatacaccc cggcaaaatc atcaagtaca aatatttttg 2501521 ttgaatcagc ttgattagta agcgctttct tttttctttt ttaaaaatga ctgcatcaac 2501581 agccggcgct tgcgcttctg ctgttttcat tttttcctag cctcctttca cggattcttg 2501641 cattcactgt agcgcagcag gcaaaagtcc gtctacaatc atatgatcac atcctgtttt 2501701 atccctttat aatcaagggt tcagccggtc cacctgaaaa aaagacaccg atattagaaa 2501761 atgattattg acaatatcta tcaatctttg gattaattgt attaaggtga agtggatgtt 2501821 atgaaatggg gggttttatg aaaagaagcc aatacaagtt ttactacaaa ctgatcacgt 2501881 ttttctgcct gctcagcacc attccggtta ttttggtcgg attattttcg tacgagcact 2501941 ctcagaaaac ggctatttcc aacgtttcgg aggaaaaatt cgacacactc cagcagaccc 2502001 agcaaagcat cgagcatata ttgaaaaccg tcgatcactc tttaacccac tatgtgagtt 2502061 cgccgcctct ccttcgcaca ttgtccgagc ctttgcactc agaccaattt caaatctata 2502121 accaagtgaa ccaagagctc aattatctgc aaagctttga taccgatctg tccaacatga 2502181 cgttagtcag ttatacgaaa aaatggtaca tgaacaattc cggtttgtac cgtttgaata 2502241 cagacactct tcatgaagca gcctcagcgt acacgaaaca aaaagcgagc cgctcctatt 2502301 ggacgcttga ggaaaacaat catttgattt caaccaaaga aggcacagca gaaaactgcc 2502361 gctacaatat caatttaatt aagcagcttc ctttgaacag cacaaataca aagggattgg 2502421 ccgccgcaag catcccgagc tgttcgcttg tcaaaaatat gcccggctat tcaaacgcca 2502481 acaacctgtt tatcatcgat gaaaaaggcc tcatcatcct tcataacaat atgtctgacg 2502541 ttggtgaatc tcttcataac gacggctttg tccaaaaagt gctggcgcaa acggccaata 2502601 gcggacagtt tgaaacagtg attgaccgga ttcattataa agtcacctat caaaaatctg 2502661 actataatgc atggacttat ttttctctcg tttccctgcc tgagttaaaa aaagaagcca 2502721 aatcaatcgg ctggatcact tttgcagtat gcctcatttt gttaacgctt tcattgctgt 2502781 tctcttggct tggctcccgc catttttaca agccgatcag ggtgctttac gaatcattcg 2502841 caagacatgg agccatacaa gagaaacaac agcctcctca aaatgaattt gagttaattg 2502901 aacagagctt taagcagctg aaggacagaa atgacgacct tgaagaaacg atgaagcagc 2502961 aggccactca tctgcagcaa tattttatgg tcaggcttat gcttggaaaa ctgacggatg 2503021 aggaggttga taaccgtttt gaaagcctcg gcttaaagca aaattggcgg caccttgccc 2503081 tgcttgtgct ccaaattgac acactgaatc atacgcctta tgagaaaaaa gatatggatc 2503141 tgcttttgtt tgccgtcaac agcctgattg agcgcaacat cccgacggac aaacatcttg 2503201 cccccgccgt agttgacaaa cagcaggcga cgattttgat caatcaaagc gggacaaagg 2503261 aagaattcat ggctgagctg aatgagactg caaggatgat tcaggaaaaa gcggaagctg 2503321 agctgcagct gtctgtcagc atcggcatca gccagccgtt tgatgtgctg acaaaagcga 2503381 aaacagccta tgcggaaggc tcagaagcgt tgaaatatcg gctgaaagcg gaaaacaagt 2503441 cgatcatctt ttacgaagac cttgaccaga aaaaaacctt caaaacccat tttccaaagc 2503501 agcttcagca tgagctgttc gatgctgtca aagcaggaga caaggagaaa gcggataaat 2503561 gcctgcacgc gattttacaa gccattttca cccagaacac caacccgtat caatttcaaa 2503621 tcgccatcgc ccgttttttg aaccatgtga ttgagctgat gcatgtgctt gggatcgaat 2503681 tgtttgagct tgaagaaaac aaaatgctgt atgaccaaat ttttgagctg aaaacgttcg 2503741 aggataccga aaactggcta aagaatgagt ttattgatcc gatgacagac aaagtgaacg 2503801 cccgcgcgga tgcccagtac aaaaatattt ccgacaacat cattcatatc atccatcatg 2503861 agtttgaatc cgaattgaca ctggacgaaa tcgcacgcag gctgcattac aacccaaatt 2503921 atttaagcag tattttcaaa aaagaaatgg gaatttcatt cagcgagtat gtctcaagct 2503981 accgacacca tatggcgaaa agctggcttg ccgaaaccga catggcggtc aaggacattg 2504041 ccgaaaagct gaaatataaa aactcccaaa acttcatcag atcatttaag aagctggaag 2504101 ggattacacc gggaaactac cgccagcaaa aaagaagcat gtaaaaaacc caaaaccgct 2504161 tgcgcgtttt gggtttttcc aatgttattt tgcttgttta aacgcttctt cgtattcctg 2504221 aataatttgt tttcctccgc ttgactccca tttttccact tctttatcga actggctttc 2504281 tgtgatgtct ccaatcatat atttgtaggt cgcgtcatca atgattttct tcagttcgtc 2504341 accccgttcc gactccgatg cggaatacag gctttcagcc gggtttgaga cgataatctt 2504401 ttcattgtcc tcggtcagct cctcgtacgc cgtccgaagc ggatctccag tgttttttaa 2504461 gtaggcttta tcaatggcaa ttaaagcgga cagcggctga atatcagtct gccagtcttt 2504521 tacctggctt tctttgcgtg taaacgtttt gtcctcacct ttgttgtaat gaacgccgtc 2504581 aatgccataa gtcatcaggc tatagacatc ttcttcggca attcggtcaa aaaacgccaa 2504641 gatccgttta agctcagctt ccgttttcac actcgttttc gggaaagcaa acacgccgtt 2504701 atggcctcct gatgcccata cccgctcttt cccatctggg ccttttatgc ggttgatgat 2504761 ctcgagcttc atcgatttat cagaggcatg gtcgcgcaga ttgaccgcat ctaccatatt 2504821 gccaatataa attccggctt ttccttgaga aaacagctct tgctgctggg ttttgcttgt 2504881 gacgggaaaa tccttattca tatacccgtt atcacgcagc tttttcatat agttcatcgt 2504941 gtctttgtat tcctgtgtca tgaaatcagg cgtgaatttg ccgcccgatt ccttccaatc 2505001 tgtcggcatg ccttcatacg agccaatcgt tttaaacgcg ccgtaaatca agtcattacg 2505061 gtctgccagc ccgaatgtat catctttccc atccttgtcc gggtcgtcct ccgtaaatgc 2505121 tttggccact tcataaagct catccaacgt tttcggggtt ttcaaattta aattgtccag 2505181 ccagtccttc cgaatgacga tcccctgtct ggaaagcggg cgctctctgt atatcccgta 2505241 gagcttgccg tcaattgtca catttttatt aatgagtttg ttcattttgt ttaagttggg 2505301 ataatccttg atataatcgc cgatttccca aaacattcct gaccgaaagg cattcatgac 2505361 tgacgaattt ttaatatcct ggatggtcac gatttgcgga agattgccgg ctgcaagcgc 2505421 tgcattcagc ctgtcttctt tcaccgcgtc tggaacccag gtgatgtcga gttctgtatt 2505481 tgtcagcttt tcaatttctt taatcgccct gtctttcggc ggctgctggt gatacaaaat 2505541 cgccatccaa gacagcttta cctttgaatc tgggccagct ttgccttcag ccgaagactg 2505601 atcagttcct ttacagcccg ccagcactcc gccgagtgcc agtacaagca caatcaaaag 2505661 caccctccat ttgtttccca tcgtacccct ccgtttcata tttctttatc ctttgacaga 2505721 tcccagcaaa gctccttttg caaaatgctt ttgtataaac ggatagacaa gcagaacagg 2505781 gatggtcgcc accactatga ccgccatttt aatggtttgc tcaggcggcg ggctgcccga 2505841 ccccatttca gacatatccc cctgcatacc gcttgataca atgacgattt ggcgcagaag 2505901 cacctgaatt ggccattttg ctgaatcatt taagtacaag atcgctgtca tatacgtgtt 2505961 ccaatacgtg accgcataaa atagtgaaat cgttgcgatc gcaggaagag acagcggcag 2506021 cacaatttta aagaatatgc ccagatcatt gcacccgtca attttcgcgg actcttccag 2506081 gcttgacggg atattttgaa agaagttttt cagaatgatc aggttaaagg cattaatggc 2506141 tgtcggcaaa ataagcgccc agtaagaatc gagcaatcca agcgatttga ccacaaggaa 2506201 agtcggaatc atgccgccgc taaacagcat cgtaaatacg acgagaaaca tgagcggctg 2506261 ccggccgatt aaatcacggc gggataaccc gtaagccatc agtgacgaaa gaaacatgct 2506321 gaccgcagtg cctatcactg tcacaaacac agaaacaagc aaactcttat aaataatatc 2506381 tgttgaaaaa atgtagcgat aagcatctag cgaaaaagtg gtcggtatta aaataaattt 2506441 tttcgacacg acttcttcta ctgtggcaaa ggatgctgcg ataacatgaa tgaacggaag 2506501 tacgcatatt aaagcgaaca tcagcaagaa accataaatc aacatatcaa acagacggtt 2506561 tttcagtgaa tgtgcgatag ctcccacctc cctttgtaag cgttatcata tttttggaaa 2506621 ccgagctcag catgtgacga tatcgtgtct aaaatgtagc aaatctgtga ttgccatgtc 2506681 tataatcatt tgaacagtgt ccccggccgg gcgggggctg ccgcgaattg agaccgataa 2506741 caaaagaaaa agagcataat cttagaaaat gattatgctc cgttctcctc ctcgttcaga 2506801 agttcagccg tattgatttg tggcgaaaac ccaagttcat tcacggcaga ttcaatggac 2506861 catggccggc ccggattatc agagacggcg taataagtgc cataccggat gttggtctca 2506921 atggcggctt tgaaaatcga cagcagatcg gggtgagaaa gcagtgtctt tttcgtccgt 2506981 tctttttcat gcagcgtatc catttcatct gtcacgactg ttccgattcg aaggttgatt 2507041 actgatagct tattttccaa ataaaacaaa tggccgatct gttcagaggt cagctttaat 2507101 acaccgtaca agttttttga cagcggataa tcgcttgttg tgatttcccg tcctaagagc 2507161 gagcgcccgt ctttttcata tacatctgtg acatgattgc tgctggcgaa cacgagcttt 2507221 tgaatgccga gctccgctgc cgcacggcac agataatagc ttgccctata gaaaacatcc 2507281 gtcatttttt caaactcagc gatgtccata atatcgtatt tgattttcac agcgagtaaa 2507341 ttcaagatgg catcggtatc ttttggaatc ttcttcaaca gctcctcata atttgccgcg 2507401 tcagcctgaa tggaagaggc tttgccatcg aaatgatctt tatcaagcac agtcacttca 2507461 tagtctgaaa taagcccttc agcaagcagt ctcccaatca caccatttcc gccggcgatc 2507521 agcacttttt tcacgatgtt cactcccctt ttttatagat tgcccatttt cggcggggct 2507581 gacacttttt tggcactcac attcttaggc ttattcaaaa gtcaccggca gctcctcaag 2507641 cgcccgaaat ccaaaaagcg gccgataccg ccattcaaaa tccgcaagat taaggctggg 2507701 cattcgctgc agaagagtgt taatcgcaat ttgcgcttct aatcgtgcca gcgaggaccc 2507761 taagcaaaca tgatggccat gcccgaatga aagatgcgga ttaggacttc tcgtaatatc 2507821 gaagacatcg gggttcgtga atatgctagg gtctcgatta gccgctccta acaaaagata 2507881 gacttgttct ccttgacgga tcgtcacccc gcagatgtca atatcctctg acgcaactct 2507941 ggctgtcatt tgcgtggggc tttcatagcg taaacattcc tcgactgcgg taccaataag 2508001 atctggattt tctctcagtt tcaaaagctg ttctggatgc tgcagcagac aaaggactga 2508061 attgctgatg agattgaccg ttgtctcatg tccggcgatc gccagcaata tgcacgtaga 2508121 tgccgcctcc tcttccgtca gcttatcctt ttctctcccc ttcaagagca tgctgatcat 2508181 atcctgttga gggtggcgtt ttctcttttg aatcagctct ttgaaatatg ccatagcctg 2508241 cacagccata atattgccct ctgttaatgc ctttcttgag cgggtaaaat caatcgtttg 2508301 aatgagactc gcagcccact cctttaattg ctccctatct tcctccggta cacctataat 2508361 gttagctatg acaaaacttg ctaaaggaaa agcaaagtcc gaaatgacct ccatcttttt 2508421 tttaccttgc acttgatcaa gcaaatgatg gacagtttca atgatatacg gctgataact 2508481 ctctgtcgtt ctcggcgtaa acgctccgct ggcaagcgtc cgcaatcgtc tatgatcagg 2508541 ctggttctga aacagcatca tttgattttg cacatgtgaa aggtcctgat atttggttga 2508601 gctctcaggc agcggggtgc ggactttgaa tctcgcatct ttcaaaatag cagccgtttc 2508661 ttcatatcct gtgacatacc agcccgggta ttttaagaaa ctccctttat agataggatg 2508721 aacagctcgc aatgtgtcgt aaaaagaata tgggtttttc aaaaactcag aagatgcagt 2508781 tgacgatgca attgtcacgt gattttctcc tttctgttca aaaataaaaa caatcgacat 2508841 cataccgatt gcttttattg attctttcag cttttcgcac ttaaactagc cttcatttct 2508901 tcgactgatt caacttcaaa gcctaaatca ctcagcattt tatgatcctc cgtctcctct 2508961 tgcccggcag ttgttaagta gtctccgaca aaaatggagt ttgcggcgta aagccctaat 2509021 ggctgcaatg tgcggagatt gacctctctt cctccggaaa tgcgaatttc ttttgatgga 2509081 ttgataaaac ggaacagcgc cagcactttt aaacaataca gcgggtttaa ttcgttgacg 2509141 ccttctaacg gcgtgccatc aattgcatgc aaaaaattca caggaatgga atccgcgtca 2509201 agagccttca agcttttggc gatgtcaatg acatcctgtt tcgtctcctt catcccgata 2509261 atggcgcctg aacacggaga cagccccgat tcttttgcga tttcaaccgt attgactctg 2509321 tcatcgtatg tatgtgaggt tgtgatgttt gaatggtttc tctgtgacgt attcaaatta 2509381 tgattatagc ggtctactcc tgcatctttg agccgcttcg cctgctctgg cttcaacagt 2509441 ccaagacatg cacaaatctt cagtccatac gtctctttaa tttcctgaac cgcatctacg 2509501 acctgatcca cttctctgtt agacggacct ctgccgcttg ccacgataca atatgtgccg 2509561 atattcagat cgtgcgcccg cttcgcgcct tcaagcagcg tttccttatt caccatccgg 2509621 taagactcaa tcggcgcttt cgaaatcgca gactgtgaac aatagccgca gttttccggg 2509681 cagagcccgg atttcgcatt cataatcata ttgagcttta ctttttttcc gtaaaagtgt 2509741 tttctgatgt gaaaagcccc gtgcattaat agcaaaatat cttcatcagg acaatgtaat 2509801 attgaaagcg cctcttcgtc agtcacttct gctccagcca gcacccggtc tgcgagttcc 2509861 atccattgat tcattctcat acccccactt gattcatcag taatgataga ttgatatggt 2509921 cttttaccat atgtagaacc gtttctttcg tcacgttggc aagctttggc gtaaccccta 2509981 aaatcggcac accgcataag cgctcaatca tctcaggatt ggttttttca tcttcatcag 2510041 gagagtcact gattccattg atgataattc cggcgattgg aagccccatg ctttctgcat 2510101 atttgacagt taaaaaggta tgattaatgg ttccaaggcg aggacgcgcc acaataatca 2510161 tgggaagctg caacgctttt atgacatgac tgaccaaata gtcctctccc aatggcacag 2510221 aaataccgcc tgcaccttct acgatgaagc attcatgttt ttctctaatc cgcccccaat 2510281 ggcttaaaac ctcttccatg gtgacagtct ttccctcaag tttccctgca acgtatggtg 2510341 caagcggcgc cttgaaggca aaaggcgtaa tgtcttcatg agaaagactg gtctgcgaca 2510401 tatctttcag caaacttgta tcactatctg gatgatggcg cgatatcccg cttaaaaatg 2510461 gtttatacac cccgacatgt ctattattgt ctttcaataa ggcagcaaga ccgctggata 2510521 taaccgtttt ccctacttct gtatcagttc ccgtcacaaa aaaacccctc aaatgatgtg 2510581 cagctccttt ccgattgaat gaaatgtttg cagcaaatga tcaatatcac ccatactgtg 2510641 gtcagacgtg attgtaattc gaatccggct ttcacccggc gcaacggttg gcggccgaat 2510701 ggcaggagca taaattccct tgccctgcag tttttcagca aataggaccg ttttatgggc 2510761 atcgccaatg actacaggaa taatcggtgt gtgatctcct ttcaccacat aacccatatt 2510821 cttcagactg gttctgatca tgctgatata agaaaataaa agctgtcgtt tttccctgct 2510881 ggcttcaatg atgttgaaag cctcgtgagc agccgcacag ctggctggcg gaatagcggt 2510941 ttgaaagata aatgttctgg catggttcag caaaaagtcg atgaagaccg ctgatcctgc 2511001 cgcaaaacct ccttccgcgc caacagcttt gcttaaggtg ccgataacaa tgtcgggaca 2511061 aacaccaaag tattcactcg ttccttgtcc cgaatcgccc aaaactcctg ttgcgtgggc 2511121 atcatcaacg accacgaagg catgatagcg tttcgcaagt gagatgatct gatcaagagg 2511181 ggcgattgtg ccatccatgc tgaatactcc gtctgttacg ataaaacggc gctgataacg 2511241 ctgtgtttca ttcagcttgt tttcaagatc attcatatca atatgccgat aaacaactgt 2511301 atcagcctta gaaagtcggc agccgtcgat catacttgca tgattgagct ggtcacttaa 2511361 aatgacatct tccttttctg gcaaggatga aaggacaccg acattggcca agtaaccgct 2511421 cgaaaacagc agggccgctt ctgtcagttt aaagctggca atcttctttt ctagcttttc 2511481 atgccagacc gaattgcctg tcgttaaacg tgaaccgctg cttcctgtcc caaattgctg 2511541 caatgctgtt tgggctgcat cgatcaaacg tctatcgctt gcgagcccta aataattgtt 2511601 tgaggaccag accgtttgat tttcgccatc aatattcctc tctggaaccg gcgctccatc 2511661 cattgaccgc aggttacgat gtacgccggc ttctttcatt ctgtctaacc gctcgtttaa 2511721 ccaggaatca atcttcaagg ctcgtaacct cgtggatcgc ttgtttcata atggcaacca 2511781 tttccgagag ctcttcagct gtgctggcaa gaggaggaag aaatgcaatc acgtccccaa 2511841 gcggtcttgt cagcattcct aactctctca tttttaagga aactttgtat ccaatccgcc 2511901 gatcagccgg gtaaggttct ttagtttcct ttgatcgtac aagctctgca ccgcacataa 2511961 agccaagctg ccgaatatcc ccaacatgag gaagagcgtg cagatcttga agaagaaaat 2512021 ggagcttttt acttttttcc gctacttgtt ccacaatgtt ttcagattca aataatgcca 2512081 gattttcaag cgcaaccgca cagccaagct gattgcctgt ataggaatgg ccatggaaaa 2512141 aggtttttag gttttcataa tcatcataga atgccttata gatgtcttca gtggcaaacg 2512201 taacggcaat tggcaaatag cctcctgtaa tgcctttacc ggcagccatc agatcaggct 2512261 ggacattctc gtgctcgcac gcaaacattt ttcctgtacg gccaaagcct gtagcgactt 2512321 catcaacgat cattaagaca tcgtatgttg tacatagctc gcgcacgcct gccaaatatc 2512381 cttccggcat cacgatcata ccggacgcgc cttgtaccat tgattcaatg gaaagcgcgg 2512441 caatttcctc atgatgttcc tcaagcagct gtgcaagctc tcggaggcac tgatcacggc 2512501 actcatcagg atcaccgctt tcagaacgat acacataagg aatcggggcc ttgtaactct 2512561 cgaacatcaa cgggccgtat acgtggtgaa aaagctcaat tgaaccgaca ctgacggcgc 2512621 caatcgtatc accgtgatac ccgtttttca ttgcgatgaa tttttgtttc tcgggcttcc 2512681 cgatgttctt ccaatactga aacgccattt ttagggctat ttccatcgcc tctgcgccgc 2512741 tgtctgaata aaagacccgc gtgagctttt ttgggctgat gtcgattaat gtttcggcaa 2512801 gctgggttgc tggaacattg gtcatgccca ataacgtgga gtgcgcaatt tttccgagct 2512861 gtttttttat ggcgtcatct agttcttttt tgcggtgtcc gtggacatta agccaaaccg 2512921 atgaaaaacc gtcatagtat tccttgccgt ttatgtcttt gactttgatt ccagtcccgc 2512981 tttcgatgat taaggggttt tcatcataat ctttcatttg ggtaaatggc agccagaggt 2513041 gctttttact tttttctatc aaatcatgag tcatgatctt cctcccactc tattaaaata 2513101 ggctgcttct ccaggtcatg tatgtacgtg tttacatcat tggatccatc aataaaaaag 2513161 actcggcagc cctcttcagt cccgtattct ttcattgctg taatacgctg atagcccatt 2513221 ttcttacccg caacatagcc tgttatgtaa tccggatcgt ccgaccagca taattctgca 2513281 acgactgccg ggtgccggct tacctttgaa gcgagcgcaa gggcctcttt tattcttgaa 2513341 tgagctggca cgtgactgtg aagcgcccat ttttcaaaat tagcgtccgg ccaatccatt 2513401 ctggagaccc gcaccccttt ttcttttgtt tgatccattc gcttgcctgt atgaatatca 2513461 aacaacaccg cacccctgac atctgaccat tcagggattt gttcatatgc tttttcaatc 2513521 acgtctcgtg aaacgccttc tttttccaat aacaatcggg caagcttttg tccttcttcc 2513581 gggcagctca cttcattcgt atgcacaggc aatggctgaa tggtttttat cgattcatgt 2513641 acctcttcaa attgaatttg cataaaatca ggttttcctc ttgaatggga taaccctttt 2513701 tctaataaag cattgactgt atgcttcatc tcatggaaag gaataagccg ttctccgccg 2513761 gatatatgct ttccgccgtc ttcatgagat ccattcattg aagccctcat tctgacacta 2513821 taaaaagttt cttcttgcat catttctcgc cctttcactg ataactgaag aacgtgtagc 2513881 gcttctcacc taaattgtta accaattata ttcaaaggtt aacaattaga atatattatt 2513941 ctctcctgtt tctgtcaata gaagaaagga tcgatttatg gcagttggtt aaaaggaaac 2514001 aaaaagaccg ttttcacaca aaacggtctt tttcgatttc tttttacagt cacagccact 2514061 tttgcaaaaa ccggacagct tcatgcctta taactgctgt ttcgaaatgt cccgaagcag 2514121 aacggaccac tcggtagcaa tcagcagctc cctgtccagc atagacagct gtcaattctt 2514181 tttcgatttt gtccacgccc tcagccggcg ttaaccgatc gtgtacacca acaagactaa 2514241 ggtgcgggcg cggcgcgatc aggctttgga tctccgatgc ggaaaaatgc tttgcaagcg 2514301 atgggacgta ataataaaag ccgtgcctgt caagattctg tgttttgatc agcacgtgat 2514361 gatccacctg gctgcacaaa tccacacaca ccttaatccg gtcatcgagc gccgctgtcc 2514421 accacgccat caaacctccc atagacatgc cgatggttcc gatcctgtca ggctgaacat 2514481 cagagcgtga ctgcatatag tctaacgcac ttaaactgtc ataaatcatc atcccccaca 2514541 tcacttttcc ggtgagaagc atttctttaa atatctcgct ttccgctttt ccccgccgat 2514601 ctccaaaccc ccaatgatca atcgcaagaa cgccgtatcc gagtgaagta agctcatcag 2514661 aaaaagaagg cgttttcaaa taatccgctc cctcaatcag ctcacttttt cccctatcat 2514721 actggcctcc atgcgaatgc tgaaacaata cggctgggca cggtccttct gttttcttcg 2514781 gcttcacaaa ataagcgggc gccttttcat gtccatttaa atcgagcagg agcgtttcaa 2514841 cgatattttc ttctctttct tcaatacgta atgtctcaac actgattggc ctccgatcag 2514901 gcaaatcacc aagcaatcga aacagttgct ttcttctttc ggctctcatc ccatcaccct 2514961 tccttattcg cttacttcac atttacgaga cagatctggg ttccccttta tttttccaac 2515021 ataaatcaca tcatttacta aatatttagt aaatattatg gaatatttcg aaaacaatta 2515081 ttgtaaccgc ttacttttat atgataatat caatttatca aaaacagatg agttaatatt 2515141 ttactaaata gatgagaggg atacccatgg ttcgtattaa agatatcgcc ttgaaagcta 2515201 aagtttccag cgcaactgtg tccagaattt taaatgaaga tgagtcgctt tctgttgcgg 2515261 gcgaaacgag acaaagagtc atcaacatcg ctgaagagct tggttatcaa accgttgcca 2515321 aacgccgaaa atcccgcggg caaaaacagc gggctcagcc gctgatcggt gtgctgagct 2515381 gtctgtcccc tgatcaggaa aggcaggacc cttatttttc ttccattcgg aaagggattg 2515441 aaaaggaatg ctttgaacag gaaattttca ttacaaattc gattcatctc ggctcctttc 2515501 aggaacatat ctttcgggaa ttggatggtg tcattgtcat cggccgtgtt catgatgaag 2515561 cggttaagca tatcagcggg aggctggagc atgccgtatt tatcaatcat tcaccagatc 2515621 cgcaagcata cgattcgatt ggcatcgatt ttgaatcggc ttcacgccag gcgattgatc 2515681 accttttcga cttaggctac aaacggttag gctacattgg cggacaagaa aaagagcata 2515741 cgctgaagga cggccaaagc attcgcagaa cgattgaaga taaacgcctg accgcttttt 2515801 tggagtcagc cgccccccag cctgagcatg tgctgatcgg agaatacagc atgcgtgagg 2515861 gctatcgcct gatgaagaaa gcaatcgatc aaggccatct gccggaagca ttctttattg 2515921 ccagcgattc tatggcgatc ggcgcattaa aagcgctgca ggaagccgga ctgcaagtgc 2515981 cgcgggatac cgcaatcgtc agctttaacg gcattgagga agctgaattt gccagcacgc 2516041 ctttaacgac ggtgaaggta tacacagagg aaatgggccg gacaggcgta aaactgctgc 2516101 ttgaccgtct caatggccga acgcttcctc aacatgtcac cctgcctaca acattaatcg 2516161 taagacaaag ctgcggatgt acagcaaagg aggtgacata agcaaagatt catcacgatg 2516221 ataaggagga aaagatgaaa cacacttttg ttttatttct ctctcttatt ctgcttgttc 2516281 tgcccgggtg ttcagcagag aaaagctcag cagataccgc aaaaaagacg ttaaccattt 2516341 attctacaat gtcaaccgac agtgaaagag atacgttcag aaaactagcg gcagcattcg 2516401 aaaaggaaca cagtgacatt catgtcagcc ttcatttccc aggcaatgac tatgaaaata 2516461 tgatgcgtgt cagaatggcg gccaatgatt tgccagatct attcgataca catggctggg 2516521 ggaaaatcag gtacggagaa tatacagcgg atctccggga tatgaaatgg actcaagatc 2516581 ttgatcccaa tttaaacagc atcctcaaaa ataaaagcgg aaaggtgtat gcctatccaa 2516641 tcaatcaggc aaaagacggt ctggcgtata atcgcaatat tttagaccgt tacggcattg 2516701 ctccgccgga aaccatggat gactttatca aagcactgag aacgattaaa gaaaagagca 2516761 agggaagcat tgttcccttc tggtttgccg gatatgacaa aagctcattc gcccaatatt 2516821 acgaccaatt cgctacacct cttctcatca cagaccctgc ccataatgaa aaaaaacagc 2516881 tcatcaacgg cacttttcaa tggagtaaat tcacttattt atcagaaatc ctcaaacaaa 2516941 tgcagaaaga aaaattgatc aatatcgacg ccgtcacggc aaaaaaatca cagctcattg 2517001 aattaatggc ccaaaacaaa atcgccttta caatgcaagg cggcacactc ggccaagacg 2517061 ttgcccagat caacccgaac gtcaaggtcg gcattatccc gacacctgcc atccatcccg 2517121 gtgatgaccc gatatggatc ggcggtgaac gctacaccct tgcagcatgg aaagattcgc 2517181 ctcaattaaa agaggcaaaa gattttatcg catttatggc ccgcccggcc aatgccaaac 2517241 aaatggctga agccacatcg cttccttcag ggctgaccaa tgtgaaagct gatattttct 2517301 acgcaaacga ttatgagtat tatcaagatg tcaaagtcga gccttacttc gaccggttat 2517361 acttgccaaa cggaatgtgg gatgtcctgg gcacggttgg gcaggagctc gcggctgaca 2517421 ttttggcgcc tcaagacatt tcgcagaagc tgggaagaga atataaacga ctccgggagc 2517481 aatccgaaac acagggagct gaaaacaatg agtgagatcg caagggacgt tcatgtgaaa 2517541 caggttaagc caaaaaagca gtcctcactt tggtggatgt acattcctgc tttgctctcc 2517601 gttctggtct ttatgattta cccgtttgtg aaaggcacat tgattacctt tacaaactgg 2517661 aacggatttt cacaagtcta ccaatgggtt ggattcgcgc aatatgaaag gctgttttct 2517721 gatcctgata cttggcatat cttaaaaaac acgctgcatt acgggcttgg cagcaccttt 2517781 tttcaaaatg tggtcgggct tctgtacgct ctcctcttaa atcaaagcat taaaacgaaa 2517841 gcggtaacaa gaacaattgt gtatttgccg gtgatgatca gcccgctcat tatgggctac 2517901 atttggtact ttttcttctc ctatgacgga ggcgcgctca acgatttgct cggggtcttc 2517961 ggcatcagcc ctattaatgc gctcgccagt ccctcgctca atccatggat cattgtcatg 2518021 attaacacct atcaatatgt cgggatcgct atggttgtct acttagccgg tctgcaaagc 2518081 attccgaaag actactatga agcggcgcaa atggatggcg cgaaacaagg ccagcagttt 2518141 tttaccatca cgctgccgct gttaatgccc tccattacca ttaatatagt catcaacatt 2518201 atcggaggct taaagctgtt tgacgtcatc attgcactca ccgcaggcgg ccccggaaat 2518261 gcgtcacaat ccatgtccac gtttatgtat gatttgtatt tcaaacggca ggatgccggc 2518321 tatgccgcaa cgcaaggcat atttatggca tttgtcattt tgatcatcag cttttgcgcg 2518381 cttgcgtact ttaaaagaaa ggagacggaa atgtcatgag agccgcccgt acaaaaagca 2518441 tgcggatcat tacgcttctt gcagccattg tggcctgtgc gcattttatt cctttttata 2518501 tcctgctgac cacttcattg aaagcaaaag gagactacag ttcgaaatgg atatttccag 2518561 ccgacatctc ctttcataat ttttcagagg cgtgggagcg cgcttcgcta ggaaactctt 2518621 ttataaacac catgatcatc acaggttttt ctgccttgtt attaattata ttcggctcac 2518681 ttgccgccta cccgcttgcc cggcgggaaa cgaaactgaa taaagccgtt tttgccttgc 2518741 tgatttccat tatgatcatc cctccgttaa cgtccatggt tcctttgtac cgaatggtcg 2518801 tggacgccgg aatggtcaat acacacgcaa tcgccatttt catcaataca gcggcttaca 2518861 tgccgttaac cgtattctta tattcaggct ttatccgatc gaccattcca aaagagcttg 2518921 tagaagccgc aagaattgac ggtgcaggca tgctgaaaat cttttttacg attgtgtttc 2518981 ctctgctgaa gccgatcact gcgaccatct gtatcatttc ttgtgtcttt atttggaacg 2519041 actatcaatt tgccattttc tttttacaag atcaaaaggt tcagacatta acagtagcca 2519101 tggcaggttt tttcggagaa aacgcaaaca accttcattt agttgccgca gcggcactta 2519161 tggcaatgct gccgatggtt gttctgtttt tggcgctgca aaaatacttt attgccggcc 2519221 tgtcttccgg agcggtaaag ggttaacatt aaagggggaa gcaatatgaa aaagattaca 2519281 tttatcggtg cagggagcac gattttcgcc aaaaatgttt tgggagactg cctgttaaca 2519341 gaggcactga atggatttga gttcgctctt tacgacattg atcccaaacg cctgcaggaa 2519401 tcccagctca tgctcgaaaa tctaagagac cgttataacc caagtgtggc catcaacagc 2519461 tatgatgaca gaaaactcgc cttgcaaaac gcaggctatg tcatcaatgc gattcaggtt 2519521 ggaggataca aaccgagcac agtcatcgat ttcgagattc ctaaacggta tgggctgcgc 2519581 cagacgatcg ccgatacagt aggcatcggc gggatattca gatctctcag aacaatcccg 2519641 gtcttatttg atatcgcaaa agatatggag gaaatgtgcc ctgacgcatg gttcttaaac 2519701 tatacaaatc caatggccac tcttacaggc gccatgctcc gctataccaa tatcaaaaca 2519761 atcgggctct gccacagtgt tcaagtgtgc acgaaggatt tatttaaagc tctcggaatg 2519821 gagcatgacg gaattgagga acgcattgcg ggcattaatc atatggcttg gcttttggaa 2519881 gtcaaaaaag acggcacaga tttatatcca gaaatcaaaa ggagagcgaa agaaaaacaa 2519941 aaaacaaagc atcatgatat ggtgcggttt gaattaatgg ataagttcgg ctattatgtc 2520001 acggaatcgt ccgaacataa cgcagagtat cacccgtact ttattaaacg gaattaccct 2520061 gaactgatca gcgagctgca aatcccgctc gacgaatatc cgagaaggtg cgtcaagcag 2520121 attgaaaatt gggagaaaat gcgggatgat atcgtcaata ataaaaacct tacgcacgaa 2520181 cgctcaaagg aatatggttc aagaattata gaagcaatgg aaacaaacga accattcacc 2520241 ttcggaggaa acgtcttgaa tacagggctg atcaccaacc ttccttcaaa agcggttgtg 2520301 gaagtgacat gcgtcgccga cagaaaaaaa attacaccgt gcttcgccgg agaactgcct 2520361 gagcagcttg cagccttaaa ccggacgaat attaatacac agctgatgac aatcgaagcg 2520421 gctgtcacac gaaaaaaaga agcggtttac caagctgcaa tgcttgatcc gcatacaagc 2520481 gcggagcttt ccatgaagga catcatctcc atgtgcgacg atttatttgc agcacacggc 2520541 gattggcttc cggaatacaa ataaaaacta ggggaccgct ctcccctagt tttttggttt 2520601 tgtttcgcct tcccaggcca tcatgccgcc ttcaacattg actgttttaa agccttgctc 2520661 atccaggtac ttgcagacgt tcatgctgcg cattcctgag cggcagataa atacgtactc 2520721 tttgtcttta tcaagggttt ccattttttc aggaatatcc cccatgcgaa tatgaacggc 2520781 ttgcgggatc atgccttccg ctacctcttc atcttctctg acatcaatta aatataattc 2520841 ttcgtccgcc tcaatttttt ctttcaaagc ggctgtgctg atttctttta tttccaaaga 2520901 aaacactcct attcacagtg atcatgttca gtatatcaaa gtcagccgaa cgattgctat 2520961 tctgagactg atgaaaaaaa atcccctttt ggcaaagggg attttttcta ggcttagttt 2521021 gccacaatat tgacaagctt cccaggcacc gcgatgattt tccgaatcgt tttgccttca 2521081 agctgctctt tgaccttttc atctgcttga gcaagctgtt ccagctgttc tttcgttgca 2521141 tcggcaggaa cctgtaattt cgcttttact tttccgttca gctgaacaac gatttcaact 2521201 tcatcatcca caagttttgt ttcatcatat acaggccaag cttcgtaggc aattgtgccg 2521261 gaatggccaa gcttctccca tagctcttcc gctaagtgtg gcgcgacagg agaaagaagc 2521321 ttcacgaagc cttccatata ttctttcggc agttctgttg ctttataagc ttcattaata 2521381 aagaccatca gctgggaaat acccgtgttg aaacgaaggc cttcataatg gtctgtgact 2521441 ttcatgaccg tttcatgata gacgcgctcc aatgtttcac ccgcgccttc aacgattttt 2521501 ccattaagct caccgctgtc ttcaataaat aggcgccata cacggtcaag gaaacggcgc 2521561 gcaccgtcta atcctgattc agaccaggcg attgaagcat caagaggtcc catgaacatt 2521621 tcgtacaatc tcagcgtatc agcaccgtga gaggccacga tttcgtcagg attgacaacg 2521681 ttccctttag atttactcat tttttcgttg ttttcgccga gaatcattcc ttggttgtac 2521741 agcttttgga acggttcttt cgtcggcact acgccgatat cataaaggaa cttatgccag 2521801 aagcgggcat acagaaggtg aagcacggca tgttctgcac cgccgatata catatcgacc 2521861 ggaagccatt tttccaattt ttctggtgat gccagctgat ccggattgtg cggatcaata 2521921 tagcgcaaga aataccagca gcttcccgcc cattgcggca ttgtattcgt ttctcttctt 2521981 ccttttttcc ctgtctcagg gtctgtgact tccacccact ctttaatgtt cgcaagcggt 2522041 gattcgcccg ttccgctcgg tttgatttca tccgtttttg gcaaaatcag cggcagctcc 2522101 tcttccggga cagctgttga cgttccgtct tcccaatgaa tgaccggaat cggctcgccc 2522161 caataacgct ggcggctgaa gagccagtca cgaagacggt acgtcacttt cttctcaccg 2522221 tttttcgttt cttccagcca agcgatcact ttttcaatcg cttcctgttt gtgaaggccg 2522281 ttcaggaaat cagagttcac gtgctcgccg tcgccagtat aggctgcttc ctcaacgttc 2522341 ccgcctttta cgacttcctt caccggaagg ccgaatgttt tggcgaattc aaaatcacgc 2522401 tcatcgtgtc ctggaactgc catgacagca cctgttccgt atgatgcaag aacataatcc 2522461 gcaatccaaa tcggcagttt ttctccgttt acaggattga tcgcatacgc tcctgtaaat 2522521 acgcctgtct ttgttttcgc aagatctgtg cgttctaggt cactctttga ttgaatttct 2522581 ttgatataag cttcaacagc ttctttttgc tctgccgttg tgatgttttc caccaatgcg 2522641 tgttccgggg caaggacagt gtatgtagcg ccaaacagcg tatctggtct tgttgtaaac 2522701 actgtaaagg aatcatcatg tccatctata gcaaaatgaa cgtgagcgcc ttccgaacgg 2522761 ccgatccagt tgcgctgcat atctttaatg ctttccggcc aatcaagctc ttccaagtcc 2522821 tcaaggagcc tgtccgcata agcggtgatt ttcagcatcc actgcttcat tgggcgtctc 2522881 tctaccggat ggccgccgcg ttcgctcttg ccgtcaatga cttcttcgtt ggcaagaaca 2522941 gtaccgagcg cagggcacca gtttacaggc acttcgtcaa cgtaagcaag gcctttttcg 2523001 tatagcttta agaaaatcca ttgcgtccat ttatagtatt cagggtcagt cgtattgatt 2523061 tcgcgatccc agtcatatga gaagccaagc gcttgaattt ggcggcggaa gttatcaata 2523121 ttctgcttcg taaacacagc ggggtcgttc cctgtgtcaa gcgcgtactg ttcagctggc 2523181 aggccgaatg cgtcccagcc cattggatga aggacatcat agccctgcat gcgcttcatg 2523241 cgggacagaa tatccgtagc tgtgtatcct tcaggatggc cgacgtgcaa cccagctcca 2523301 gacggataag gaaacatgtc cagcgcgtaa aatttttgtt tttcattatt atcaagagtg 2523361 gcaaatgttt tgttttcaag ccaatatgtc tgccatttct tttctatctc tttgtgctga 2523421 aaactcaaag taaaaacctc cttctgattg aatacggcgt gtatggttca agtattgacg 2523481 ggaaggagag gattatattc agaatattcc caaactaaaa aaaactccct catcccaaaa 2523541 agggacgaga gactttcgtt ttcccgcggt accaccctcg ttagcgcggc atacgccgca 2523601 ctcacttgat acttttaacg cagttatgcg tcagcggctt ttcaccgctg caactctgag 2523661 gtgagttcgg aaacaaactt gattgacttt caccagccgt caactctctg caacaatatc 2523721 tgtttcttac tgctcctctt cattgttctt atcgcaaccg taatctaact gtattttata 2523781 gaattctgtt cataagtgca agcaggtttg tatacaatgg gaatgtaccc tgaacgggcg 2523841 gagattgagg acaattattc gggtggagtt ttggtttgac gtttggactc ggccggttcg 2523901 ccgccgctgt tcagttctct cacaaagtca aaacttctga gaacagcttc accgccgtag 2523961 cctgagataa tggataagat gacaagttga attcctgaat cggggtcagc ggataataca 2524021 agtaaaatgg aagccgtcat gccgataaac caatcttcca aaaatccaag gtagataaac 2524081 cgcttcgtca ttctgggctt ctccagcctg cctctctttt tcacatgacc gagaatcccc 2524141 atgattcctc caattacaca agcaatgagt acctgatgca gcatcttcat catcaccttc 2524201 ctaaagccct tatttcgtaa agcgacttca ggccatccag cccccttaaa cgattccgat 2524261 gattttcgat atctacatac cggcaaatct gtaaaaagct tgtttcttcc attatatgtg 2524321 aacacatgat cggtaagctt gatgcattgg attcattttt cacccagtga cattgaccta 2524381 gtcacctatt tagcatgtag aaaacctttc cgttcatatg ttcaaattct gttcttattt 2524441 ttagtgtata cgaggacaag ccctaatgac aaacaacaaa ctgcacttgc ttgaatcaga 2524501 acatgtgttg tgctacggtt actgtagaat tcatttttaa aaaggggaat atcaggcttt 2524561 cgcatagcaa gctgacggcc taagggggat ttatatggct agttttcaat catttgggat 2524621 accaggacag ctggaagtca tcaaaaaagc acttgatcac gtgcgagtcg gtgtggtaat 2524681 tacagatccc gcacttgaag ataatcctat tgtctacgta aatcaaggct ttgttcaaat 2524741 gaccggctac gagaccgagg aaattttagg aaagaactgt cgcttcttac aggggaaaca 2524801 cacagatcct gcagaagtgg acaacatcag aaccgcttta caaaataaag aaccggtcac 2524861 cgttcagatc caaaactaca aaaaagacgg aacgatgttc tggaatgaat taaatattga 2524921 tccaatggaa atagaggata aaacgtattt tgtcggaatt cagaatgata tcaccaagca 2524981 aaaagaatat gaaaagcttc tcgaggattc cctcacggaa attactgcac tttcaactcc 2525041 tattgtcccg attcgcaatg gcatttcggc tcttccgcta gtcggaaacc tgacagagga 2525101 gcgatttaat tccatcgttt gcacattgac gaatatctta tcaacatcca aagatgatta 2525161 tttgatcatt gatttatccg gattggccca agtgaacgaa caaacggccg accaaatttt 2525221 caagctgagc catttgctga aattgaccgg aactgagtta atcattactg gcattaagcc 2525281 tgaattggct atgaaaatga ataaactgga tgccaatttt tcgtcgctga aaacatattc 2525341 aaatgtaaag gatgccgtta aagtgcttcc gattatgtaa aaagatcccg ctcacccagc 2525401 tggatctttc agattgttga caaaatccta aaatggtttt cattttagga ttttgtcatc 2525461 ttttcagcgt gattgaaaac ccttgaagtc taggaaggac gagcatagga gcggagcgaa 2525521 tgttctaatt cgtgagcacc gaagcgcagg cctgacaacg aatgcgaggg tttgtcgaca 2525581 cgctgaaaga tcccgctcat tcggcgggat cttttattat gaagagattg atgcctgctt 2525641 atttgtttct ttagctgatt ttatccgttt gtcatataga agcgttgtgg caatactgat 2525701 cagcagcaat accaacagag ataaaacaag agccctaatg ccgtaatgat cgacaagcac 2525761 tcctccgaac aggggaccaa tcattctgcc gcctgtcgcc gcactgttga caaagccttg 2525821 ataaaagcct tctttccctt taggggcaag ctgattggca atagtcggca cagcaggcca 2525881 aacaagcatt tctccgatag tcaggatcac catcgcagcg agaaacatcg gaaattgctt 2525941 tgcagtcagc agcatgctga aagacacaat aaaaatgata aagccgatga ccatttgcgc 2526001 ttttagcgac tcggcccatt ttttcaccac aaaactgacg agcggctggc cgagcacaat 2526061 gagaattccg ttaaccgtcc acagcacgct gtataaggaa agagatattc caatgctttg 2526121 tgtgtacgaa gcaattgtgg ttgaccactg agaataagcc agccatccga gtacatagcc 2526181 tccgcttaaa atgatcagtg cggcaaattt tgctttgctg ttcacagcat cataatcaag 2526241 cacggatgtt tgggatgcat cgcccgtttg aatatttcga aatccgaaat atacaataaa 2526301 gaaaaagatc agatacaata cggcatttgc caaaaataca tatgaaaacg agaaagatgc 2526361 cacgacaccg ccaagcgctg aaccaacggc cacgcccgcg ttttgcgcga catatatcgc 2526421 attaaatgcc ttccttcccc cttcaggcca taccgatccc gccattgcgt agcttgccgg 2526481 aaaaacaaca ccggagccaa agcccacaat cgtcagcagc acaatatagg ctggccaatc 2526541 atgaaaaaag acaagaccca tcaggcttgc taacgtaatg gctatcccaa gcataatcga 2526601 tttaaaaccg ccgattttat caaacaaaaa acctccgcat aaattgccag ccacactggc 2526661 gccggaattc agcatcagga caagtccggc tactgttaac gactttccta aatgattatg 2526721 gatataaatc gtattcagcg gccataaaaa agaagcaccc gtcacattga taaacattcc 2526781 aatgactaaa attttaagag cacgcggcat actcatcccc ctttcttacc taaaaaagct 2526841 catgaaaaaa acgaaaccta aaacggctcc gtacgaatcc agttatcata gcacattcat 2526901 tctatctgtc tctctcacat ttttcaactg atgagcgtga aaaaatctaa caaatattgt 2526961 ttgaaaaatg taaaataaat agaaaaaggg gtcatattat ggaaatggta ttagcattct 2527021 taggttttct ggcatgtctc attgcactgg gctatggatt atatcacctt gtcagatatg 2527081 tactgaaaaa ggaaaaacgt ttctcaaaga gacttttttg gccgcttttc attggaggcc 2527141 ttgtgctgct ctttaccggg gcagcattgg cagaacctga cactgccgca gcaaatgccg 2527201 agaaaaaata ttcagcgcta aacgccgaat ataaaaacct cacaaaagag cacgaagaac 2527261 ttgagaaaga atataaatct gtcagctctg aagcaaagaa attaaaagac aacaaagaag 2527321 atcaagacaa gcttgagaag cttaaaaacg aaaatagcga tctaaaaaag actcagaaat 2527381 cattaaaagc tgagattaaa gagcttcaag aaaatcaaaa gcagctcaaa gaagatgcaa 2527441 aaacggcaaa ggctgaaaat gaaacacttc gacaagataa aacaaagctt gaaaatcaat 2527501 taaaagagac ggaaagccaa accgccagct ctcatgaaga cactggaagt tcttcaaaca 2527561 atacgagtaa aagtgatgaa accaaaacag ctgacaaagc agaaggctgt aatatcaaag 2527621 gaagcagaaa cggcatctac cacacgccag gcagtacata ctacgaccgg acaaccgatc 2527681 cggctgaaat gttttgctca gttgaagaag ctgaagccgc cggttatcgg gcgccaaaac 2527741 gataaacaaa aagctccaga atgtctggag ctttttctgt ttcacaacga cgatttaatg 2527801 accttcttat aataaagaac tgacagaaaa ccaaaaatgg agtagagcgc agtatataac 2527861 accatcacca taatcatagg cgcccatacc tctgatccga ataagaacca gccggattgg 2527921 acggcaaagt aactgtggaa gaggccgaca acgagcggaa tgccgaagtt gtacatttgt 2527981 ttgatgcgta tcccctttat caggtcgccc tgcgtaaagc cgagttttct taaaattgta 2528041 tagctcggtt tttcatcttc actttcaccc atttgtttaa aataaaggat acaacctgat 2528101 gtaatcagga acgttaaccc taagaagccg acgatgaaca tcaccatacc aaacagtgat 2528161 ttttgcgcag cgcttgtatc tagtcttgat aaatgctcgt ttttcttgtt cacctgttga 2528221 aaaagctcat ttgctttttc catttgatcg tcatgtttca cattgacgcc gataaatgta 2528281 gattgcgcca gctgaatgcg ggggtcttta tccttgtcca gctgtttaaa caggctgtca 2528341 tccacaatga cagcgggcat gcccccgctt gtaaacgtgt aggacacaag aaactcttct 2528401 cttaatcctt tatattttaa tggctgcgtc tcgtgcttgc tttttacttt aataacacca 2528461 gagtccttga aaaccattat tttttgcagc aagtcggtgt atcctgagaa aacggcttct 2528521 ccagccgcca catcgactcc ttttacatct ttgtcgctaa caacagcaag ctgcatattg 2528581 ccgggatcgc cctgcatctc tttcggagtt ccatccataa tatttgcaat gtcaacattt 2528641 gcttgcagga caggtgttgc cttttttaca aacgagatgt tgctttccct caatttgttt 2528701 tcaaataact tggcatcttt ctcattcatg aatgaaaaat cagccgctac attttgttca 2528761 gcggtctttt ccgacgagta atacgagatg taagcaagag ataacagccc gatggcgagc 2528821 gctgaaacgg ttgtaataat cgtcagcagc agcgcattcg atttcattct gaacatgatc 2528881 gaagacagtg acagaacctc agaaatattt aagtagccgc ccttgctttt tcgaatgata 2528941 ttcgagataa acgtaactga tcctttataa aacaaaaacg tcccgataat gacgctcccc 2529001 agaatgaagc tcatcgcaac aaacagttca ttaatggtct taaattttcc gccaaacagc 2529061 tcagaagaca catagtatcc tgtcaaaatc aacacgatgc ctaaagcgcc gatcagcatt 2529121 tggaaaaatg atattttctt cactttgtct tcagtggagg acgttacttt aaacaaagat 2529181 aaaatactct gttttttgat aaacgtataa ttcatgatca tgatcaaaag gtaaatgccg 2529241 cagaacacaa tgaccgtttg gaccaaggcc tgctcagaaa aatgcagttt cgcatccgct 2529301 ttgacatcga caattttgaa cagaatcatc aagacaagct tcgatatcga aaacccggcc 2529361 gctaccccga tcgctaatga accgaaatac agcatgacat tttctgcact taagatgcga 2529421 aaaattttat gcttcgtcat tccaattaat tgaaacagcc cgatttcttt actccgtctc 2529481 ttaataaaaa tcgtattggc atataaaatg aagatcgcca ctacagccac aagcaaaatc 2529541 gaagcggttt taatagccgc ggctcccttg attgaagcct tcacttcgtt aattgctgga 2529601 tcatactgca gcgtgacaaa ggcgaaataa agcgccacgc taaagatgag cgcaaacaca 2529661 tacaaatagt aattccggag attctttttc aaatttcgca ggatgagctg attaatgttc 2529721 atgctgcacc ccgcctaaca cgccttgcgt tttcataata tcctggaaaa acgtttgcct 2529781 gtcctggccc cctttattca gctgtgtata catttgcccg tccttaataa aaatgactct 2529841 gccgcagtag ctggcagcga cgggatcatg ggtaaccata ataatcgtcg cgttgcgttt 2529901 ttgattgagc tggctcagct tatttaatag atcggaggcc gatttcgaat cgagcgcgcc 2529961 ggtcggttca tcagcgaaaa taatgctcgg gtcatgaata aacgctcttc cagcggatgt 2530021 tctctgcttc tggccgccgg aaatttcatt cgggtattta tcccgcaatt catatattcc 2530081 cagttccttg gcaacttcct caaacttgcg attggcttcc ttttttgata gtttcgtgat 2530141 cgataaaggc agaaggatat tctctttcac tgtcaatgtg tctaacaaat tgtaatcctg 2530201 aaagataaag cctaaatgct gttttctaaa ttcagccagc tgcttttcct tcatagccgt 2530261 catgtcattt ccattaatat gaatggttcc gtgactgacc tgatcgattg aggacagaac 2530321 gttgagcaaa gtggtttttc ccgacccgga agcacccata atactgacga attcgccctt 2530381 ttcaatgtga atatcgatgc ccttcagcac ttcctgttta ttcagcttgt ttccataact 2530441 ttttcgaatt ttattcgctt ctaaaatcac catttacgca gtctccttta tattggataa 2530501 tctcattata aaaaggaatg ccgggctttt ccttcgatac ggcgaacaaa aaagaaaagc 2530561 atgtgacatt ttcgtcacac gcttatgaca tgttcaaatt gattccgtat tggaaaggtt 2530621 aatgtaaaaa ctgttcccgc accaaactcc gactcaacat caatatggat caataacggc 2530681 gccgctgctt tttttgccaa gtacagcccc atgccagttg acgcttgatc atggtgatcc 2530741 gttgtggatg taaacccttt atcaaaaata cgcggtacat cttttggatc aatgcccctg 2530801 ccacaatctt tcacttggag ctgcgtctgt tccccttttt gaaagctttt gatctcgatt 2530861 tcagaggctt cgctgtattt caccgcgttt gtcagcagct gcctgatgat aaacgccagc 2530921 cattttgcat cgctcagcac ttctttggcc tcgagctgta tgtcaaaacc gatccctttt 2530981 tggatacacc acgattgtaa atctttgatt tctttaaaga tcaaaggctg aagctgaatg 2531041 aattctactg acaggtcgtt ttcaataaat gaaatgcgtt tttgatgaag ctgctgatca 2531101 agaagcaggt gaatacgcag ccattcatat gacagctggg atttcagtgc tttttcttcc 2531161 attctatcaa tgattaaatg catcgctgtt aatggagttt tgacctcatg gatccatgcc 2531221 atcagctcat ctttttcatt ttccaatgct aagcgatgcc gtgctgcggt ctgcttcaag 2531281 tgttctgttt gcccggcaat gcttctttca accattgctt caaacggcgt ttccggttca 2531341 tttatggctg tcacatcgag attgttctcc catgttttca agcttttata aaacgctgtt 2531401 tctttccgat agcggaacca aaggaatatg ataaaaaaca agatgcacaa atacaccata 2531461 taaagtacat tcccaaatga tatggaagga tcgacaaaag caatgaacag catcaaagcc 2531521 tgctgaaaca aaaacgcggc aatccagctc cgcctttcga taaggaatgc tttaatcata 2531581 gaacttgtcc tcttccttcg cgatgtagcc ctggcccacc tttgtctcga tatatgcacc 2531641 aagctgcagg gcgtccagtt tttttcgcag gcgattgaca ttgacggtca gcgtattatc 2531701 actaacaaaa cgctcatcgt tccacaagct tctgatcagc tcttcccggc tgacgatctt 2531761 gtttttttgc tctattaatt gttttagaat gaacatttca tttttggtca gttcaacaga 2531821 tcctttgtca ttgctgacga ggttctgctc cgcgtctaca gcagcgccgc accacgtttt 2531881 aatcgtactc ggctccgtat tataatggtg cacacgccgg aacatcgctt ggattttcgc 2531941 gatcagcaca tcaaaatgaa atggcttttg aataaagtca tctgccccga gctgcatgga 2532001 catcaccata tcagcaggat gatcccggga ggataaaaag agaatcggaa catttgaccg 2532061 ggagcggatc agacggcacc aatgaaagcc gtcaaattta ggcagctgca catcaataat 2532121 gacacaatca ggattaaccg ccgcaaattc ctgcagcacc tgactgaaat cctgaatgcc 2532181 gtatacatca taggaccatc ccgttaaacg atccttgatt tcatgaaaca gcgattcatc 2532241 atcttcaatc agcaaaagtt taaacaatcg actcaccgca ctttttcctt ttttatcaag 2532301 tgtatagcaa aacgccagca tgcgctatag aaaaagccgg ctgtctcagc cggctcgttc 2532361 gcattataat tctcttctca acgctgtcag cacgttggtt ttggtagctt ttctcgccgg 2532421 gttcattccg gaaatgactg cgacccctcc gcaaatcaca acggcaatga tcacaaggct 2532481 cgccgggatg taggagaatg tgtaattcaa atcgcccgca tcgccaccgc ttgtggccgc 2532541 aagaatcatc ggaacggcca ggttgacaag gtagctcacg ccgtaagaaa tgataatccc 2532601 aatcacacag cctaaaattc cgatatacgc gctttccatc aagaacattc ggcgaatgat 2532661 tgacgggctc gccccaatcg ctttcataat gccgatctct tgcgttctct ctgtcaccgc 2532721 catcgtcatc gtgttaaaaa tgccgatcgc tgaaatgata actgcgatac atccgacaaa 2532781 gatcagtccg attttgaaga ccatgaagaa ggtattggct ccctcaagtt cagtagtcac 2532841 tgatgtgaca tagtacccgt catctgttag atcatttgtc agctgttcca cattctcaaa 2532901 cttatcagca aaaacaccaa tgttcgtttc aacatttccg cctttgaaat ctaagaattc 2532961 cgaaaaatct tttttgaatt gatcactgat aaaaatattt gagtcctcca tccagtcttg 2533021 agatggtttt tttgtaatac cgacaatttt aaagtcatat gtttttgttt ttgtaacatc 2533081 ccctgtttta gaatctgtct tcgatacact tagttcaatt gttttattta gaatatcttt 2533141 cgtatagccc tttggttctt ttatatcttc tggatttcct tttgcttcct cgattttttt 2533201 gttatattct tccgattctt ttttcgttaa taatctcttt gcgaagtcgt atcctactac 2533261 gatttcattt tccgactttg cgactcttcc cttttccaat tccatattgg cctttaattc 2533321 atcattcata ttagtaaaaa tgagatttga gctttcattt gtacgattgc ctaaagtagc 2533381 tttgtttggt tcatacactt gcgttctttc tacaactgac cttacgtgat catacttctc 2533441 taaatcagct tttttaatcg gcttgtctcc ttccttgccc attacgctga ctttcgttac 2533501 aatctgctgg ctcattgtca tatctgtaat cgtcttttga atcccaaatc caacggacga 2533561 caacacaacc aaaaacgcac acgccattgt tgtcgccaga atcgtcataa agacgcgaag 2533621 cctgtttttc ttcatatttc ttctgataaa atgaacctga tccttaaacc tcaacggtaa 2533681 ttcctccttt tagcacacca tcatgaagct gaaattttga atgtccgata gaagcgactt 2533741 catcatcgtg agtaatgatc acaaatgtaa tgccacgctc acgattcagc tgctggatca 2533801 attccagcac ttcatgttcc gtttctgaat caaggcttcc cgtcggctca tccgctaaga 2533861 taatcgaagg atttaaaatc aatgctcgag caatactgac acgctgctgc tggccgcctg 2533921 acagttcatt cggataatga gcggcgtggt tttccagacc gacgcgtttc agcatgtcct 2533981 gcaccttttg cttccgctca gatggcttga ttccttttaa cgccagcggc atttccacat 2534041 tctcatacgt cgttaaaccc gggatgagct gaaagctctg aaaaataaac ccgaaatggt 2534101 caagccgaaa ttgcgcccat tccttttcat taaaccccgt aacatcagtg ccattaatga 2534161 caatccgccc ttttgtcggc gatatgtagc cggaaattaa attcaaaagc gttgatttcc 2534221 ctgagccgct tcgtccgaca atgcaggcga tttccccttt cgccacgctc aatgaaacat 2534281 ccttcaatac tggaacttca ttctcacggc ccttttttcc gatcgtgaaa gaatggtcga 2534341 tatgctgaac atcaatcata tgttctctct cccttacaaa agtttcattt ttttataaat 2534401 cgcaaaataa ctaatcaaga aaccgattac cgcacctgta cccatgccaa tgagataacc 2534461 ggcaaagctc tcgcttgcag taaatccaaa atagccgaag cccatgattc ctatgataat 2534521 aacgatgatc tgcaccgggc ggttaagcgg cttccataag aagaaatatc cgtttctttc 2534581 attagacatt ttaacaaagc taatatagcc gatgatgtaa aaaatgatag tcatgatagc 2534641 cggaatgact aaataatatg gtgaattctc agcccatttc gagtctacat aaattatcgg 2534701 aatgaaatac tgcacccatt taggtactgg accatggata aaatctattg atccgccaaa 2534761 aaggatctcg aggttgatca caggcaggct gatgagtaaa aacggcgaaa tggccacggt 2534821 aaatgagact agaagctgtg cgaaactatt gcctgtcaaa gctcctccgg ccataaccaa 2534881 agaataagcc agcatgctaa caataatcat tcccaagctg taattgtgaa aataaacggc 2534941 ctgatctggc ttcaaaagca tgatcagcaa aacagacaaa acataaccta tgagctgcgg 2535001 caccacaatc accattccgc cggtaaggaa cttcgcatga aatatctgcc ctcgtgtata 2535061 tggaaggctt aatgtaaaat caaagaagct cttgctacgt tcaatcccaa gctggctgac 2535121 cgccaaaacg actccccaaa tccaaaacaa tgagataaat gagctattta aataatcaac 2535181 gctgaatacg caggggccga cccaattttc ttttccagtg acacagcctt gatagatgag 2535241 atacatattt aaaattgata atggattacc taatataaaa accaaaatgg tgataactaa 2535301 ggcgacttta ttctgccgcc actctttgta aagcagtccg gaatccggca actcacttcc 2535361 ctccaaacct aaggcatttc ttacactttt gttttcttat aaatagagaa gtagctcaca 2535421 aagaatccag ccactgctcc aatgatcata cccaaaatat aaccaataat ggaatgtccg 2535481 gtatagtatc caaataaacc aaatccaagg atgccgaaag ccataaccag aatttgcacc 2535541 gggcgatcta atctgttcca taagaaaaag tgtccgttcc gttcacttgg aagcttcttg 2535601 aagcttataa agccaatcaa gtaaaatagc atgctcatta cggctggaat caataaaaga 2535661 tatttactgt taatcagcca ttcatttaca acgtaactaa tcggtactag gttcgataaa 2535721 ttgcttgcca gagagaaata actctcaggg gaagggaata tttcccatat attcgcacca 2535781 aaaacaactt ctaggtttcc aaccggcaat gcaataatta aatacggcaa tatagctgct 2535841 gaaaacgccg ttaacagttg ggcaaaagca tttccagtta acgctccggc ggccatcacc 2535901 agtgaaaaag ccataaaact tatcacgatt actccaatgc tgctgtgctc aaaaaagtag 2535961 acgtgttcag ggttatagac aagaatcagc agccatgcaa gtaaaaagcc aatcaattgt 2536021 gacagcacaa tcacaaaacc gcctaaccaa aattttgtct gaaaaatttg gcttctgtta 2536081 tacgggaggc ttaatataaa atccatcgtg cctttcgaac gctccattcc gaggaagcag 2536141 accgccaaaa tgacacccgg cacccagttg atatctatca gattgcttat ggaataattc 2536201 acaataaaat cacaatattg cgggtcttgg cgatcaagac acccttgata agacaaatac 2536261 gtattaacga tagaaagcgg atttgccaat actaaaaacg cgatacttaa caaaatcacc 2536321 acttgattct gcttccactc tcgatagagg agacctcggt ctaccatctc cgcttccctc 2536381 caaacttcgc aatgaacact tcttccaggt tgacaggaag ctcattccac acttttggct 2536441 tcagctctct caaaaagctc tttttctcct catcgctttt cggaatcagc actgtgtaaa 2536501 acacgccggc ctgatcgagc atcggaatgt tttgctctct gatggccaaa ttgacatctg 2536561 tatcgaaggc catttgaatt ttaatgtatt cttcttttaa ctcatcaaga tccatgacgt 2536621 tggtcaggct gttatcttca agaaaaccaa ttcggttgca catccgctct atgtcttcaa 2536681 gccggtggga cgtaatcagg atgctcgtat cacgctctgc cacttcatcg accatcagct 2536741 gcagcacatc atgccttgtc accgcatcaa taccatccgt cggctcatca aggaggatca 2536801 gcgccggtct cgccgcaaac gacagaacga gcgatagctg cttttttaag cctgtcgaca 2536861 gctcacggta ttttttcgtt tccggaattt cgtatctgtt catcagctca ttcgcgtacg 2536921 tgacatcaaa tttcggatat attcttctca aaatatcgac taactgcttg tatgtatact 2536981 tatcgtaaaa cggattttga acaggcatgt agatgatatt ttgtttgact ttcgggtgct 2537041 ttttgatttc tacgccgtca aataaaatcg ttccgctgtc agcgaaaatg atttgctgga 2537101 ttaagcgaag catcgtcgtt ttgcccgatc cattgcgtcc aagcaatcca aagatttctc 2537161 ctttttcgat tgttaatgaa acatctttta atacttgatt gccgtcaatc gcttttgaca 2537221 gctgccgcag ttcaatcatt ttttttgcct cccttcacat cagcgctgat ttcctttatc 2537281 cattcgtgca gtttttccag ctcaacccct gcatagtgtg catcgatgat gagctgtttg 2537341 agttgctctt taatcatcgt catcttccct tcaaccagtg tcgtttttgc attctccgat 2537401 atataggtcc ctctgccccg cagcgtttca ataatcccct ctcgctcaag ttctttatac 2537461 gctttgctga cagtgttcgg attcgcaata atgatcgttg ccaattctct gacagaagga 2537521 agcttatcac caggcttcat gatccctttc aaacaaagct ctttcatttg ctgaataatt 2537581 tgttcgtaaa tgggtgttga gcttcttgga tcgatttgaa tcatttactt ccctactttc 2537641 tatacgatct gaacctttta tagataaaaa tgatcaatta tacttttttg ccattcaaaa 2537701 ccgatcatca caagaacaag aaaaaaagaa caagcgatca cagatgccgc aatcagcatt 2537761 ggcacgttac gtttgtttcg ttttttatgt ttcataactg cctcccttaa tgtcaatata 2537821 taaatgattt tatattagtg tctatagtgt attacttcaa ttagtacact taatacaata 2537881 aatactttga ctcacaaagt caatcctttt tttacaaaaa aacggaccct tttaaaaggg 2537941 tccgttttcc tacacatcaa gagggtgctg caggatcata ttattttgca aagattgaag 2538001 ctgaagtctc attctgtaca gctgttctct ctgctgatca tttgacgaca gccatagttt 2538061 attcaaggca tttaccgcat cttctagctg catttgtgca tcactatatt cttgatcgtt 2538121 ataatgctct tgtttagaag cgattttcag ctgttcttca gcataatcat aggcctgcat 2538181 acattgctgg agatgttcat ctactgattg tcttgttgcc acagtaaccc ctcctcttgg 2538241 taatggaaat catccatcat tcatattgta gcctcatctg actttattca ataaagtaat 2538301 ttatggtcga tattcatttg ttctcttgtg aaatgcgtgc tacaatttta ggatgcaatc 2538361 gtacgcaagg aggcacatga attgtgatgc agaacaatcc ttttccttat tcaaatacgg 2538421 aaaaacgcta tcatacattg aattatcatc tcagagaaca tttcggccat aaggtgttta 2538481 aagtagcgct tgacggcggt tttgactgtc caaatcggga tggcaccgta gcccacggag 2538541 gctgtacgtt ttgcagcgca gcaggctccg gagattttgc tggaaaccgg accgatgatt 2538601 taattacgca attccatgac atcaaaaacc gcatgcacga aaaatggaag gacggcaagt 2538661 acatcgctta ttttcaggct ttcacaaaca ctcacgcccc ggttgaggtg cttcgtgaga 2538721 aattcgaatc cgtcctcgcc ttagatgatg tggtcggcat ttcgatcgcc acacgcccgg 2538781 actgtctgcc tgatgatgtc gttgattact tggcagagct gaatgaacgt acgtatttgt 2538841 gggtggagct tgggcttcaa acagttcatg aacggactgc acttttgatc aaccgcgcac 2538901 atgattttaa ctgctatgtg gaaggcgtca ataaattaag aaaacacggc atacgtgtct 2538961 gctcgcatat tatcaacggg ctgcctttgg aagaccggga catgatgatg gaaacggcaa 2539021 aggccgtcgc agatttggat gtccagggca ttaaaatcca tctgcttcac ctactgaaag 2539081 gcacgccgat ggtcaaacaa tatgaaaagg gcaagctgga atttctttct caagatgatt 2539141 atgtgcagct cgtctgcgat cagcttgaga tcattccgcc tgaaatgatc gtccaccgca 2539201 ttacaggtga cggaccgatt gagttgatga tcgggccaat gtggagcgtc aacaaatggg 2539261 aagtgcttgg cgccattaat aaagagctag aaaatcgagg cagctatcaa ggaaagttct 2539321 ttcaacggct tgaggaggaa tcagcgctat gattttgaag aaaattcttc cttacagcaa 2539381 agaactgctg aaaatggccg cgggagaggg agatattgtc gtagatgcga caatgggcaa 2539441 cggacatgat acacagtttt tagcggagct tgtcggtgaa aacggccatg tatacgcatt 2539501 cgacatccaa gaatcagccg tggccaatac aaaggaacgg ctcggtgaca tgtatcaagc 2539561 gcgaacaacg ttatttcaca aaagccatga taaaatcgct gaatccctcc cgcctgaaac 2539621 acatggcaaa gtggcggccg cggtatttaa cctcggctat ttgccgggcg gggacaaatc 2539681 aattacgaca aacggcagtt ctacgatcaa agccattgaa cagcttctca gcatcatgaa 2539741 agacgaaggt ctgattgttc tcgtcgtcta tcatggccac ccggaaggca aagctgaaaa 2539801 aaacgacgtg ctcgagtttt gccgggactt ggaccagcaa acagcccgtg tattaacata 2539861 cgggtttatc aatcagcaaa atgacccgcc atttattgtc gccatcgaaa aaaaagctca 2539921 gatcagcaaa tgatttgagc ttttttcttt gaatttttca tccaggacat tttttgaaat 2539981 ttccggtagg ctctgccgtt gatataaaag aaaagggagg tttttccgct ggctttgatc 2540041 agcttctttg cgagccggac ctgcttcgtc ttactttacc atttttcaaa ttatatttga 2540101 aagcaataac catcgttaac ccggacgtca tacagttcgg gtttcgattt ttccataaaa 2540161 cgttcacata tagcatgaaa cgtatgactt ttatcttatc acaaaactat aaacagcctc 2540221 tgcaaaaaca catacctatt ctttcctgtt ctctattttc tatgagcaca cacaaaaaga 2540281 gcccactggg agctcttttt gtcagctgat atttcgttcg ctggcagcag ccgcattttt 2540341 tttatgaaac ccttttccat agtacacagc cagcaagatg agaaaccata tcggcccgat 2540401 aatcacggct actcttgtat cagggctgta agccataaga atgacgacga atgctagaaa 2540461 tgccaatgac acataagacg taaacggaaa taaaggcatt ttgtacttta attgtttctt 2540521 ttcttccggc ttcaaacttt tcctgtattt tatttgagaa agcaaaatga ttgcccacgt 2540581 ccaaatcgct ccgaacgtcg caatacttgt aacccaagta aataccttcg cagggacaac 2540641 atagtttaac agcactccga ctaataaagc gcccgctgaa gccagaacag ctttacccgg 2540701 gatgccgcct ttcgtcagct gaccatatgc ttgtggcgcc tctttctgtt ccgccaagtt 2540761 aaacagcatc cgccctgtgc tgaaaatacc actgttgcat gaagacagcg cggctgtcaa 2540821 cacgacaaag ttaatgatac ctgcggccga tggaatgccc actttttgaa atgtgagaac 2540881 aaatggactt ccttgagagc caatttcctg ccacggataa atagacataa tgacaaataa 2540941 agcgcctaca taaaaaatca aaatccgcca aaatactgta tcgattgctt tggctaacga 2541001 tttttgcggg ttttttactt cgccagccgt caccccgatc atttcaatcc ctaaataggc 2541061 gaacatgacc atttgaagag acaataaaac cccttttaat ccatgaggga aaaatcctcc 2541121 gttgttccac aaattgctga ttccggttgc aatgccccca ttgccgactc ctgcaataat 2541181 catcaataaa ccgacagcaa tcatggataa gattgcaaca attttaatca atgcgaacca 2541241 aaattccagc tcgccgtaag ctttgacagc caggaaatta acacccgtca taatgaccag 2541301 tgccgataac gcccaaatcc agtttggcac gtccggaaac cagaacccca tatagatgcc 2541361 gacagcagtg atttcggcca tacaggtgac aacccataaa aaccagtagt tccaacctgt 2541421 taaatagcct gcaagcggtc ccaaataatc acgcgcatac ctgctgaagg agcctgcgac 2541481 cggtttttga atggccattt ccccaagcgc tctcataata aaaaacatga ccaggccgct 2541541 tgcggcatac gctaccaaaa taccaggccc tgctaattga atagctgatg cggagccgag 2541601 gaacaaccct actcctatag cagctcctaa agacattaaa gaaatatgcc tttcttcgag 2541661 tccgcggtgc agctcttgtt tttgtttttg catgcttctt ctcccctaga aaaaaatatc 2541721 attatatcat ttttctgaat attccgtacg gattgggtaa atcaatgatg atggagaaat 2541781 aaaaggataa caacaaggct ttcgactact cgaaagcctt gttgtctgtt acacaaagat 2541841 gacttcttta ggctgatggc tcagctcttc aggcatatac cgtttttcaa tattgatgct 2541901 gtgccagatc ataaagatta gcacagtcca aattttacgg ctgttatcag ccttgtccgc 2541961 acaatggtct tcaagaagct gaaggacata atccttatgg atataagcat ccgtttggct 2542021 ttcttgaata atattccgca cccattcgtt catttcgttt ttcagccaat gacggatcgg 2542081 tacagggaaa ccaagctttt tgcggtttaa tacgtgctca ggcacaattc cttcagcggc 2542141 tttgcgaaga agatacttcg tcgtgccgtt cttcgttttc agctcatcag gaatttttga 2542201 agcgacgtcg aatacgactt tatccaagaa cggcacacgc agttccaaag aattcgccat 2542261 cgtcatttta tccgccttta acaaaatgtc gccgcgcatc caagtgtgga tatcgacata 2542321 ctgcattttg ttgatatcgc tgtacgagct gctttctgta aagtaagtct tcgtcacatc 2542381 gcgatatgaa aggttcggat tataatgctt caacagctgc tttttgacag actcttcaaa 2542441 gattttcgcg ttaccgatat aacgatcctg aagcggagtg cagccgcgct caagcaggct 2542501 cttccctctc ataccttcag gcataacggc agcaacgtgc agaagcatct ttttcaagcc 2542561 ggacggaatc cgttcaaacg gtttaagcga aagcggttca cggtaaatgt tatatccgcc 2542621 gaagagctca tccgctcctt cacctgataa agcaaccgta acatgttttt ttgcttcttt 2542681 tgcaacaaag tacaacggaa tcgctgccgg atcagcaagc gggtcatcaa aatgccatac 2542741 gatcttcgga agctcattca tgtattcctc aggcgaaatg actttgctga tattttcaat 2542801 gcccagcgcc gctgccgttt ctttcgctac atcaacctca ctgaagccct gctgttcaaa 2542861 gccgacagag aatgttttta agcttggatg aaattccttc gcaacagaca caataaagga 2542921 agaatcaatc ccgccagaca ggaacgaacc gacaggaacg tcacttctca tatgaacgtt 2542981 tacagagtca tagatcgcgt ctcggacttc tttcacaagc ttgtcttctt cagtctgaac 2543041 cggcttgaag ttcgctttga aatacgtttt gaatgtgata tcgccgtccg ggcggattgt 2543101 gaattgtgaa cccggctcta cttttttcac atgggcatca agcgtgcttg gttcaggaac 2543161 aaattggaaa gacatgtact gctgcaatgc ctctttatct atttcaatat cattctgagc 2543221 aaccattaaa ctttttctct ctgaggcaaa ataaacctga tcattgatcg ttgtgtagta 2543281 caacggttta atgccgaatg gatctcttgc cccataaagc acatgatcgt ttttattcca 2543341 aatcagaaag gcaaacatac cgcgcagttt ggacgccgct tcttctttat agtgacggta 2543401 agtcgcaaga agaacctctg tgtccgaatc cgtgttgaat gtgtacccct ttgcttcaag 2543461 ttcttctctc agttcgatat agttatagat ttctccgtta aagataatcc aatatgtttc 2543521 atcttcatat gataaaggct gtccaccatt ttctacatca ataatgctga gccgtctgaa 2543581 tccgaagccg acgtgctcat catggaaata tccatcactg tcaggaccgc ggtgaacgat 2543641 catttggttc atttgtttga ttagttcttc ttgatcagcg gtttgagcta acggatgctt 2543701 gttaaaaacc ccgacaaatc cacacatagt attgcctcca taattaaaat tgtcatcatt 2543761 gaacccctat ttatagacgc tgtgaatagt atttggtttc acagttatgt aaaaaaataa 2543821 acatgaatac aacgataaaa aagggaaagc cgcttaacca gtaagcggct ataaaattat 2543881 tctcctaacg cttctttacg cagctgctcc gctttgtctg tgcgctccca tggaaggtca 2543941 acatcgtgac gtccaaagtg gccgtacgca gcagtttgtt tatagatcgg acggcgcaaa 2544001 tcaagcattt tgataatgcc ggcaggtcgt aaatcaaagt tattgcgaac aacttcaatc 2544061 agtttttcct cagaagcttt tcctgaaccg aatgtgttga ttgagattga cacaggctgt 2544121 gcaacaccga tcgcgtaagc aagctgtact tcgcaagaat cagcaagctc agccgcaacg 2544181 atgtttttcg caacgtatct tgccgcataa gctgcagaac ggtctacctt cgtcgcgtcc 2544241 ttacctgaga acgcgcctcc gccgtggcgt gcatagccgc cgtacgtatc aacgatgatt 2544301 ttgcgtcctg taagtcccgc atccccttga gggcctccga ttacgaaacg tcctgtaggg 2544361 ttgatgaaat attttgtttc ttcatcaatc agctcttcag gaacaaccgg attgattaca 2544421 tgttctttaa tgttgcgctg aatttgctca agtgtaattt cagggtgatg ctgagttgaa 2544481 ataacaatcg cgtcaatgcg gactggtttg ttattttcat cgtactcaac cgttacctgt 2544541 gttttgccgt cagggcgaag gtacggaaga atatcttctt tacggacttc acttaggcgg 2544601 cgggctaatt tatgggcaag tgaaattgga agaggcataa gctctttcgt ttcgttgcac 2544661 gcataaccga acattaatcc ttggtcaccc gcaccaatcg cttcaatttc ttcgtcgctc 2544721 attgtgcctt cacgggcttc aagcgcttgg tctacgccca tcgcgatatc agcagactgc 2544781 tcatcaattg atgttaaaac cgcacaagtt tccgcatcaa atccgtattt tgcacgtgtg 2544841 tatccgattt ctttaatggt ttggcgaacc gttttcggaa tgtcaacata cgtagaagtt 2544901 gtgatctctc cgcttacaag aaccaaacct gttgtcacag atgtttcaca agcaacacgc 2544961 gcgttagggt ctttctttaa aatttcatct aaaatgctgt cagaaatctg gtcacagatt 2545021 ttatccggat gcccctccgt aacagattct gatgtaaata aacgacgatt tttactcatg 2545081 atttgcttcc tcctgcacaa ggcctcccga aagaccttgt atatatgata cggaactcgc 2545141 tccctcttat acaatgtaca gttatattag agaatgttaa ttggcatatt tatgaaataa 2545201 aaaaaccttt tccatcgagg aaagggtttg gtctttgtgc ctttcactct tatcgctcaa 2545261 ggaatcatac aaccttgcaa caggttagca ccttggttgt ctcactcagt tgaacataat 2545321 aaataacaga gaaaccggtt gctgggcttc atagggcctg tccctccgcc agctcgggat 2545381 aagagtatcc gctcaatgaa atatcttatc gtaaaagggt ttgcaatgtc aatatgattc 2545441 agaagaaata ggcacctata ttgagggaaa acaatggaaa tgcacacaca aaaaacaata 2545501 aatagtatag actatttgaa aatatatgtt atactaattc acaattagca aaacacaaaa 2545561 aacgataaag gaaggtttca tatgaactca gttgatttga ccgctgattt acaagcctta 2545621 ttaacatgtc caaatgtgcg tcataattta tcagcagcac agctaacaga aaaagtcctc 2545681 tcccgaaacg aaggcatttt aacatccaca ggtgctgttc gcgcgacaac aggcgcttac 2545741 acaggacgct cacctaaaga taaattcatc gtggaggaag aaagcacgaa aaataagatc 2545801 gattggggcc cggtgaatca gccgatttca gaagaagcgt ttgagcggct gtacacgaaa 2545861 gttgtcagct atttaaagga gcgagatgaa ctgtttgttt tcgaaggatt tgccggagca 2545921 gacgagaaat acaggctgcc gatcactgtc gtaaatgagt tcgcatggca caatttattt 2545981 gcgcggcagc tgtttatccg tccggaagga aatgataaga aaacagttga gcagccgttc 2546041 accattcttt ctgctccgca tttcaaagcg gatccaaaaa cagacggcac tcattccgaa 2546101 acgtttatta ttgtctcttt cgaaaagcgg acaattttaa tcggcggaac tgagtatgcc 2546161 ggtgaaatga agaagtccat tttctccatt atgaatttcc tgctgcctga aagagatatt 2546221 ttatctatgc actgctccgc caatgtcggt gaaaaaggcg atgtcgccct tttcttcgga 2546281 ctgtcaggaa caggaaagac caccctgtcg gcagatgctg accgcaagct gatcggtgac 2546341 gatgaacatg gctggtctga tacaggcgtc tttaatattg aaggcggatg ctacgctaag 2546401 tgtattcatt taagcgagga aaaggagccg caaatcttta acgcgatccg cttcgggtct 2546461 gttctcgaaa atgtcgttgt ggatgaagat acacgcgaag ccaattatga tgattccttc 2546521 tatactgaaa acacgcgggc agcttacccg attcatatga ttaataacat cgtgactcca 2546581 agcatggccg gccatccgtc agccattgta tttttgacgg ctgatgcctt cggagtcctg 2546641 ccgccgatca gcaaactaac gaaggagcag gcgatgtacc attttttgag cggttacacg 2546701 agtaagcttg ccggaaccga acgtggtgtc acgtctcctg aaacgacgtt ttctacatgc 2546761 ttcggctcac cgttcctgcc gcttcctgct cacgtctatg ctgaaatgct cggcaaaaag 2546821 atcgatgaac acggcgcaga cgttttctta gtcaataccg gatggaccgg gggcggctac 2546881 ggcacaggcg aacgaatgaa gctttcttac actagagcaa tggtcaaagc agcgattgaa 2546941 ggcaaattag aggatgctga aatgataact gacgatattt tcggcctgca cattccggcc 2547001 catgttcctg gcgttcctga tcatatcctt cagcctgaaa acacgtggac caacaaggaa 2547061 gaatacaaag aaaaagcagt ctaccttgca aatgaattca aagagaactt taaaaagttc 2547121 gcacataccg atgccatcgc ccaggcaggc ggccctctcg tataaaaaac aaaagccaag 2547181 agcaattatg ctcttggctt gttttaattg acggaatgca aagaagtcag cttgtatgta 2547241 atgatggtcc ggccttcttc ccattgaagc ttctgcactt cagctgtgcc tgacttttcg 2547301 ccaaactttg ttttgcgtac atccattgga atctccatcg gatatactcg gtatccgtcc 2547361 ttctctaacg tgaatatatt ttcatctatg cgaacttctt ttccttttgt cacaatcagt 2547421 gtattaaatt caacaggcat tcccaaagtg aaatcccctt tcgttctctt ttttctttat 2547481 cataacatat ttcactgtca gcggtttttc atccattgtg tgagctgccg cacgatacgc 2547541 cggttttctt ttggcgggaa ataatgtgtg aatgtactgt agtaccatgt ttccaccggc 2547601 ttatgcagtt gttttagctt ctcttctaat aaataggaat gctgaatcga aacattttgg 2547661 tctttttctc catggattaa cagcacggga gcctgaattt tgtttacttg gtcaaacggt 2547721 gtcctccatt gatattcctc aggcaccttt ttcggtgttc cgccgatgac tcttttcatc 2547781 attcgccgca aatcctgccg ctcctcgtat gtaagaatca tatcactgac gcctccccag 2547841 gaaacaaatg aagctgcctg cccgcccatt tcgatcgcag tgagcattcc cataattccg 2547901 ccgcgggaaa aaccgaagat atggattcta tccttcttga catttgggtg ctgctgaagc 2547961 aggcgaaaag cagaaaatgc atcctccctg tcttctccgg caaaatcctc attgccttct 2548021 cctccttgat tgcctctgta aaaaggagca aacaccacaa acccttggga tgcaaactgg 2548081 ataatccggc ccggccgaac catgcccacg cttttaatcc cgccgcgcaa atataaaaat 2548141 ccgtcatatt gtcccggttc cgccggctca gccagaagcc ccttaacccg taatccattt 2548201 gacagatagc agatcgtata caaacgcaca tgctggcttg gcgacggaaa tcttcttttc 2548261 tctacaatca aaacagccgc ctcctttttt ctatatgctt tccttactcc aaaattacat 2548321 ccggagaacc tggttaggca ttcacacatt tttataccca tcatacgata tgtaaagcaa 2548381 aaaaggatat taacttgatg cgaaataagg aggttgtcta tgtgaacaga tggttaaggc 2548441 tgggcttcgc ctgtgtcggc agtatctttc tgatgttcgc cctggcggct tgcaagcagg 2548501 aagaaacgct caccaaagtc aaagtagctg aagtgaccca ttcaattttt tacgcacctt 2548561 tatatgttgc tgagtctaaa ggttttttta aggaagaagg gcttgatgtc gatgtgaata 2548621 cgacctgggg cggagataaa acgatgacat cgcttctttc caacggctcc gacatcgcgc 2548681 ttgtcgggtc agaaacatct atttatgtcg aagcgcaagg ggctaaagat cccgtcatta 2548741 atttcgccca gctgactcag acagacggaa cgtttcttgt cgcgagagaa gatgttgaac 2548801 acttcgactg ggatcagctg aaaggaaaaa cgtttctcgg tcagcgaaaa ggcggcatgc 2548861 cgcaaatggt cggcgagtat gtactgaaca aacataagat tgacccgcat aaggatatag 2548921 acctcatcca gaacatagac ttcgccaata ttgccaatgc gtttgcttct ggaaccggtg 2548981 agtatgtaca gctctttgaa ccgcaggctt ctctctttga gaaaaaaggc atcggccata 2549041 tcgtggcttc attcggagaa gaatcaggag aggttcctta tacgactttt atggcgaaac 2549101 aaagctattt gaagaaaaat gaagacacag ccgtcaagtt tacaaaagcc atttataagg 2549161 cgcagcagtg ggttgaaaat cattctgcga aggacatcac agatgccatt aaagatgaat 2549221 ttgatgatac cgacccagac gtcatcgaaa catccattga acgctataaa aaacagcatt 2549281 catattcacc agaccctctg cttaacgaaa aagaatggga gcttctccaa accattatgg 2549341 ataaatcggg agaactgccg aagcacattc catacaatca gcttgtaaat aaagaaattg 2549401 ctgaaaaagt cacctcggag aaataggagg cgccatctat gtctttctta catgtcgacc 2549461 atgtaaccca tacttatttt tctattaaag aaaaaacaac ggctgtgcgg gatattcatt 2549521 tcgatgccga aaaaggcgat ttcatctcat ttctcggccc aagcggctgc ggaaaaacaa 2549581 cattgctttc cattattgcc ggtttgattg agccatcaga aggcagagtt ctgattgaag 2549641 gccgtgagcc gaatcaaaaa gaacataata ttggctatat gcttcagcag gattacttat 2549701 ttccctggaa atctatcgag gaaaatgtgc ttctcggttt aaaaatcgcc gacacgctga 2549761 cagaagaaag caaagccgct gcactcggtc tattgccgga gttcggcctc atagatgtgg 2549821 agaaaaaata tccgaaagaa ctgtcaggcg ggatgcgcca gcgggctgcg cttgcaagaa 2549881 cacttgcgcc taaccctagt ctgcttttgc tggatgagcc attttccgcg cttgattttc 2549941 agacaaagct gtctttggaa aacctggtat tccgcacatt aaaggaatat caaaaaacag 2550001 cagtgcttgt cactcatgat ataggggaag cgatagcgat gagcgatacg atctttttat 2550061 tttcaaatca gccgggcacc atccatcaga tttttaccat tcctaaggaa ttggccgcga 2550121 tgttgccttt tgacgcccgt caggaacctt ccttccagac actgtttcaa acgatatgga 2550181 aggagctgaa ttctcttgag aaacagcaaa gaaaccattg atctgcttca cgagcagtat 2550241 caattcaaac agaaaaagga aaagtggaag gtccattcct ttcagcttgc catatttatt 2550301 ctctttttct cgggctggga aatctccagc aggcagggct ggatcgatcc gctgatcttc 2550361 agctctccat cagctgtgtg gcgattattg ctggagaaac ttggtgacgg ttctttactg 2550421 tcacacatcg gcgtcacttt atttgaaacg gtgcttggct ttttgctcgg gacgtttatg 2550481 ggcacgtgcc tagccgcttt gttatggtgg tctaaccgac ttgccagaat tttagatccg 2550541 tatcttgtga ttttgaacgc aatgccgaaa gtggccctgg gcccgatcct gattgtcgcg 2550601 ctcggtccca gttttatcag catcattgcg atgggagcca tcatcagcgt cattatcaca 2550661 accatcgttg tctacaccgc cttccaagag gtcgacgaaa actatacgaa agtcatgaaa 2550721 acattcggcg caaaaaagtg ggttattttt aaagaagtca tactgcctgc atcctccccc 2550781 gcgattattt caacactaaa agtgaacgtc ggtttatcat gggttggcgt tattgtaggg 2550841 gaattcctcg tttcgaaggt cggattagga tatatgatta tttacggatt ccaagtcttc 2550901 aattttacac tcgtcttctt aagcctgctg atcatcgcca tcttcgccac tctgatgtat 2550961 cagggcgtcg agctgctgga aaagaaatgg acgaagggga ggacataaaa aacccggcac 2551021 atgtgccggg ttttttattc aatccatcca gattctttca gttttttcaa gctgatcgga 2551081 agaacggaat ccttcataat aaagctgaat tttttattgc gggaaaggtt ctccggcagc 2551141 tcgtgaaaca aaaccgggcc tttcgtttca aagtaatcag cctgcttttc aagcttttct 2551201 atatctgcaa aatatatatt ttttacaatc actttttctt ttccgagaac tttatactgt 2551261 ccgagatact tgaggctttt gactctcgcg cccgtctctt cctttacttc ccggagcgca 2551321 gcctcttctg cgcactccat cggctctact ttcccgcctg gaaactcata gcctctgtcc 2551381 tcatgttctg ttaaaagcca tttgccgcca aaacggcaaa tcacccagac atgcttcggg 2551441 ctgtccgaga aaggctgatc gtcaaaggaa agctgaacag tattctgata ataatcttta 2551501 aactcgtaca tgtttatccc tcaaatccgt tcctagctat cttccataca tcataccaca 2551561 gttacgtttc ttcggaagcc ttttatcaaa aaataaggga aacccagcac gccgtcaggt 2551621 tctgcatgca gactagctcg tacagttttt ttgcgatact tttgccggaa agtgcgaccg 2551681 acgctctggg ctttattatg acccgcgaac agggaaaagt tacggtttgc gcttaaattt 2551741 attttttaac gtttctaaaa gatcgacaag catctgagga accggtatgc caagagagct 2551801 ggctgtcaca acaatttgca cagattcata aagaatataa aacataatag ccaagtcacg 2551861 aattgatccc tgtgtattca gcagctgatc aaaaaagtgg catacagaga tcagagccag 2551921 cgtgactaat tttttgacaa gccgggcaaa taccttttta aatgacagtt tgtgaataat 2551981 ggtttccttc aaagtcgtac tgataaattc aattgccata agagagagca aaatcagaaa 2552041 tgaatactga aaacctccaa agaaaaaacc cgctgctgaa acgctgactg ctaaaaacga 2552101 aaagatgcca aagtctctat ccatttatcc caacatcctt tcacagaaac ggccttacga 2552161 tattctatgg taaacaagcc gaacggattg gatttttcag aaaaatggac tggttgtcgc 2552221 ctatttttca gatacaaaaa gaaaagccgg acgtcttttt taagacatcc ggccgttcta 2552281 tttttgaact taacctaggt aagcttttag catccagtta tgtttttcaa tattttgatg 2552341 gatcgcaaga agcatgtccc ctgttgtttc gtcaccgact tcatcagcta aatccatgcc 2552401 gtttttcagc tcttccgcga tgactgtgaa atcatcatat acgctttgaa ccatttgttc 2552461 agctgtttca tttccagcag cttctttgac agaagccgtt tctaaggatt ccttcattgt 2552521 tgcaatcggt tttccgttca gcgccaaaag acgttctgct aagtcatcaa tataagttgc 2552581 tgtttcgttg tacagctcct caaacttttc atgaagagtg aagaaatctt tccctttcac 2552641 ataccagtga taattatgta gtttcacata catgaccgtc cagttggcta cttgtttgtt 2552701 cactgcttga atcaattgtt ctgacatggt atctcctcct tgttatatga ctatgtatac 2552761 ccttaatatc gtacgctaaa acctcttttt tacccttatc tgtcacgatt tcttctatta 2552821 tgctacaatt gttaaaaaac gggaggtgga atgtcatgac gcttctcatt acgataagta 2552881 ttttgattgt gctggctgtt ttgcttgtaa ccatttggac gactgtaaaa gcctataatg 2552941 taaagcatac cattgatcca ccacaagaaa atcactctga ttcacacaat caatgatgat 2553001 gtgaatgctc ctcttctgac tgattgctgg cagcatcggc gtctccgact tggactttta 2553061 aggtcggcat gctatgctgt ttttttgctg tgacatgaga ttggacagtg tatacaccat 2553121 cttccttaaa cgtcgtttcc aatcggtata cgcctttttc ttgtttcacc ttaaacattt 2553181 ggcttgcgtc tttttcccct tctttccata cttcaaactc tacttcatcg gcatccgtca 2553241 cagcttcatc accatatgat acagctgctt cataagcagc gctttctccg ggatttactt 2553301 tttcaggccc ggtcagcttg acatccaaaa cctcgggcgt ctcagctgta tttgctttac 2553361 tttcaccaga tccgcatcca ttaagcaata aagcagaaaa aagcagaaca accaacatct 2553421 ttttcatgcc atcacccttt catcgtttac ctaaatagta gcaaacgctt acagcaaatg 2553481 gtacacaaaa tatgagacgt cacaaaaaag acctttttgc ttaagcgcaa aaaggtcctt 2553541 tctattttag ccaaatactt ttagcaattc ttctttatcc tgtgaaagcc agaaacgcat 2553601 taaacgttta gcgccttcca gatcatgaag cttcgcttgg ccgcactgct tttcattcgc 2553661 agcaggtatt tctgtaatct ctaccgcttc cttcattgtg tcttcaagca gatcaacgat 2553721 ttccgctgat gtcggctctc cgctcacaac tagataatag cctgtctggc agcccattgg 2553781 agaaatatca atgatatcaa aatgatcgta tttctcagcg tgagaacgaa tcgtaaacgc 2553841 gagcaaatgc tcgagtgtgt gaatggtgtc aggcttcatc gcctgtttat ttggctggca 2553901 aaaacgaatg tcaaatttat ttacaacgcc gtctgttccc actttatgca cgccgcaatg 2553961 tcttacatat ggagcaacaa ccgcattatg atcaagctca aaactttcta ctgaaggcat 2554021 aatggcactc tccccttttt taaaaatgta atttcattat aacatacttt tccgataaga 2554081 attattgatt aacttttcaa tctgtgtttt ttttcttata cttgcatcag aaaggttgct 2554141 gaagaaacat gaaaacccta ttcatcgctc tgatcagagg atatcaaaaa ttcatctcgc 2554201 ccctgacacc gccaacgtgc cgcttttatc cgacctgttc ccaatatgga atcgaagcga 2554261 ttaaaacaca tggcgcttta aaaggcggat ggctgacaat caaacggatt ttgaaatgcc 2554321 acccgttcca tccgggagga gtcgatcccg ttcctgaaaa gaaacaaaaa cattaattgt 2554381 tataaccgtt tacgataaga tccagttttc cggttttagg atcaatgact aagccatgga 2554441 ccggaacgtt ttcagggaac agcgggtgat gtttaataac atctacgctg tctttcacac 2554501 tcgcttccac tgaatcaaag cttttaaacc attgatcaaa gtctacaccg gagtacttta 2554561 ttgtttcgat gcgttcttcc ggaatccctc ttgctttgat tttttcaagc atgcttttgc 2554621 tgctgatttt gctcatgccg caatcgtgat gcccgatcac acacacctca tctgcattca 2554681 gctcgtacac tgcgacgagt atacttctca tgatgcttcc gaatgggtgt gtcacaagcg 2554741 caccggcact tttaatgatt ttcacatcac cgtttcgcaa attcatcgca tgcggcagca 2554801 gttcaaccag acgagtatcc atgcaagaaa gaatcgccat ttttttatct ggaaattttg 2554861 atgtttgata cttttcatac tctctttgtt cagtaaatgt cttgttaaat tcgagaatat 2554921 catttagaag actcatgttc gttgtccctt tctattcttt ttactcttca atatatcaca 2554981 acccttgttt attcgtcata ataaaaaaag acaaaccctc aggcctgcct tatttcccca 2555041 tgttatagcg ttttttgaac tgctcaactc gtccgccttt ttcattgaat ttctggcggc 2555101 ctgtataaaa cggatgcgtg tcagagctta cctctacttt aatgacagga tatgtgtttc 2555161 cgtcctccca ctctgctgtt tcattagatg ttttcgtaga ggtgcttaga aaacggtagc 2555221 cgctgttgac atcctgaaat atcactttgt ggttctttgg atgaattcct tctttcatgg 2555281 gtatctcctt tcaataaatc gtaataatta cgttttattt tataacctta caaacgtttt 2555341 gtcaatcttc ttatatcctt ccctctgttt cacatcgtaa acctcatggc atttaagaat 2555401 aggaagaata atctaaccga ggaagcaaat aataaaccca aaatacatac agaacgtctt 2555461 tttggaaagg tggtttacga ttgtggatga tttagttttg gccagaagcc tttttggcac 2555521 gacgatgggc tttcatatca ttttcgcaac acttggagtc ggtctgccgc tcatgatttt 2555581 agtggcggaa ttgatctatc aaaaaacgaa agatgaccat tatgcgatca tggcgaaaag 2555641 atggacgaaa gcacaagccg ttttgctggg ggtcgccata ccgaccggaa cgatcgcggg 2555701 cactcagctc gcgcttttat ggccgggatt tatggaagtc atcggccggg tgatgtccct 2555761 gccatttcaa attgaaatct atgctttttt tgttgaagcc ctattcatgt cgatttatgt 2555821 atacgctgca gaccgtttgt cacctgcaat gaggattgtt gctgttttct ttgtgttagt 2555881 cggggcagca gcatccgctg ttctgatcac gaatgttcac gcttttgaag gtacgcccgc 2555941 cggttttaaa attttaaacg gaaaaattac agatgttgac ccgtgggctg cgttttttaa 2556001 tcctagcttt tttatcactg ccggccatgt cgtgctgtcc gcgtttatga ctggtgcgtt 2556061 tatcgtggct tctgttgcgg cgtataaaat gatccgaacg aggaaaaagg aaagggtcta 2556121 tcgctttcac cggaaagccc ttttgctcgc actgacgatc ggcggtattt tttcattgct 2556181 gaccgctttg aacggacacg aatctgcaca gatgctgtac gaataccagc ccgaaaaatt 2556241 agccggtgcg gaaggcctat ttgaaacaag atcccacgcc ccgctcgcta tcggcggttt 2556301 taccgacccg aatgaagaaa aagtaaaatg ggcaatcgag attccatggg ctttaagctt 2556361 tttggcagcg aaccgttttg acactgttgt aaaaggatta aatgcatttc cgagagatga 2556421 atggccgccg cttttcattc acacgctgtt taatgcgatg gttggtgtag gcatgctgct 2556481 aattctttat tccattatcg gtgtggtctg gagaaaggtg ctcaagaaag accgtttccc 2556541 aacgtggctt ttgatcattt tcatgacagc aggccctttt agtctcatcg gcattgaatt 2556601 cggctggatt ttcgcatgta cggggaggca gccttgggtc atctatcatc tgctgaaaac 2556661 gtcagatgtc gtaacaacga ctggctcgat cggggtgctg ttcttatttt tcacatttgt 2556721 ttatgccgtg ttaggcgcag ctgtcgtcta cgtgctgctg tattatttcc gcaagcaccc 2556781 ggttgacgaa gatttaaata cagcggagtc gtaatggctc cgcaaacagg aaaccaaatg 2556841 gaaggaagat cgtacaaatg gagatttcaa ctgacgctct gatcgccatc tcaattatct 2556901 ggggctttgt gtttatttac gccgtcatgg cgacaatgga ttttggagcg ggattttggt 2556961 ctatgatcta tttaaacaag gagcatatga aggccaccga tattgcgaat cgctttttgt 2557021 ccccgacttg ggaggtcaca aacgtcttta ttgtggccat cgtcgtggcg cttttcagtt 2557081 ttttccccgg cgcgacattt gtgctcggca ccgttttatt aattcccgga agcatgattt 2557141 tgctgctttt agcaattcga agcggatttc tcgtgttttc aaatacagca aaggagcgga 2557201 aaacgctaag atatatttcc ggcatctccg gctttatcat tcctgctatt ttaattttgg 2557261 tgcttcctgt gacacacgga gggtttatag aaaaaacgga tggaatctat aacttaaata 2557321 tgtctaaaat cttttcaagc cccaacgcct attcatttat cgggtttgcg attttaagca 2557381 ccttattttt gtcctcgctg ttgcttgcag atttttcaaa tgtggcagag gaacaggatg 2557441 cgtaccgagc ctacagaaaa agcgccctga ttaccggccc gatttcactg ttgtttgctg 2557501 tatgcattat ggtaactatg cggaatgaag caaactggct gtacagcgga atgatgaatg 2557561 atttttcttg gattattgca tcgttcatta catttgtcat tgctggaatc gctctttttc 2557621 tgcctaacaa aagctttggt caaaacatcg gaaaaccgcg tctcgcactt gttgcgattg 2557681 ggatacagta ttttctcgca agctacgcgt acgggcgggc gcatcttccg tatatgattt 2557741 atcccgatgt gacagtcatg tcaggcttca cagagccagc aacgttcaga gcgctgtttg 2557801 caacgtatat cgttgcattt atcattctat ttccgggctt ctttttcttc tggaaaatgt 2557861 ttatgcgaga taaacgctat atccgccagg aggaatagag ggcaagccag ccggctatac 2557921 taatccagaa cctttataag gaggggatgg catggagcag aaaattctat gtgaggtcaa 2557981 caactgttct tattggggca aaggtaacaa atgcaccgct gatgccattt atgttgtcag 2558041 ccatactggt gaaacggctg aaaacagccg ggaaacagac tgcaaaacgt ttaagccgca 2558101 tgatttataa ttaaaagaaa gagctgcatc agccagctct ttctttttgc atgttgagtg 2558161 ttctcagctt tttagttatg accccgtttg caggtgaaaa caaaaaggcg cttgcataac 2558221 atacacctgt catggccgcc atcgctcctg aaatcgaaac attaagccac gttgcgaaga 2558281 aatagcccat gaccgccgac agcccgccaa tcaacgcgct gagaatcagc atataaagaa 2558341 gccggtctgt cagcaaatgt gccgcagccg gcggaacaat cagcatggcc acaaccaata 2558401 cggcacccac cgaatcaaag gaagcaacag tcgtcaagga cagcatgccc atttgcacgt 2558461 aatgaatgag caaaaccggt attcccaagg ctaaagccat ttgaggatca aacgaagcga 2558521 ttttaaactc cttatagcac acactgatca acactacgtt taaaaccaga acagatgcca 2558581 gcatccaaaa cgctttcggc ccaatatcaa ccccgaatac cgtcaccgta ttccacggca 2558641 caaaagcgat ttctcccatt aacgagtgct caatatcgag atggacattc gctccataca 2558701 cagaaagcaa aataaccccg attgcaaata aggatgtaaa cacaactcct atggcagcat 2558761 ctgattgaac ccccttgcta tgaagaagct gaaccaagaa agccgttaac agaccggttg 2558821 cggctgcgcc aataaacata taaatcccat cgagacttcc cgtcactaga aaagcgccga 2558881 caatgccaag caacactgtg tgactgattg cgtcggccag catcgccatg cttctcagca 2558941 caagaaatgt gccgatcaat ccgcagctta caccgactaa tacaccggta gctataatcc 2559001 atgcttcaaa actcatttgc gatctgtccc ttctcggcat catgagacgc ttttcgacgc 2559061 tcaggcatcc gtccatacag ctttaagagt gaataaagcc gctctctcgt ttctctcggt 2559121 aaacggtccg ggtcaaagta gtcctgatcg gattctatat tggcaagttc catttcatgc 2559181 atgagataca cttcatacat ccgctgcttc aaagctgtgt gatagccttt ttctatccct 2559241 ttgcttgtga tttgccaaat cccattttcg atacgctcaa tgcacctctc ttgttccaag 2559301 tcatttaatg ccttaaggca taatgaaggg gataggcgtc ttttctttct tacactttca 2559361 acagttacac aaagattatt cttttcatac tgttcataaa tcgccaaaag cacttgctcc 2559421 ctgcttgttc tgcgccgcag cctcatcagc cttatggctt tagcagccaa tccccgctta 2559481 ggcgcgcaaa tcattgaaaa aagaaagagc agcgttgcag ataagatcat taatggccct 2559541 gtcgccattc ccttcatcgt ggtgctaagc agggttccgg ccactccgct gaccccgcct 2559601 gtaatcccgg caatgatgat catcccggtt aatcgttcgg tccaatatct cgcggttatg 2559661 gcaggtgtaa tcagcatagc cgccattaat atcacaccaa cagtctgaag cccaatgacg 2559721 acagcacaga caatcagaca agccaaaagc ccgtttaaaa aacgcaccgg gattcctaat 2559781 ccctttgcaa acgcgagatc aaaagtaatc aatgtaaatt ccttaaagaa aacaatacat 2559841 aggagcagta gaacagcgga tatccctgca ataaggatga tatcctgcct gaccaatgaa 2559901 gcagcctggc cgaataaaaa agaatcaagc ccgctttggc ttcccgcccc ctgttgctga 2559961 atatatgtca gcagaatgat cccgacgcca aaaaacacag aaagaacaat cccgatcgcc 2560021 gagtcctcct ttgtttttga aagccgagga atcagctgaa tacaaaacgt tccgagcagt 2560081 ccggcgagcg ctgcccccag caaaaagaaa ggcagtgatt tttgcccggt gaacagaaaa 2560141 gcgagacaca ctcccggcag agctgaatgg gccatcgcat cgccgattaa actttgcttt 2560201 ctcagcagca caaagctgcc caaaacaccg cttgccgtcc cgagcaaaag cgtaccggcc 2560261 agcacccact gtgtattcgg atgctgaagc tgcagccaca aactttcaaa cattgcgctc 2560321 actccttatg tccttctgcc agcactttat cttttaaaaa cgtaagcctt cctccatatg 2560381 ttttttgcag gttttcgatc gtaaaaacgt tttccgtcgg tccgaaagcg attttcctta 2560441 aatgaagcag taagatccaa tcgaaataat cctcggcggt ctgcagatca tgatggacga 2560501 caagcacggt ttttcctttt tctttgagtt ctgccaacag cgtcataatc gcgcgctccg 2560561 tcgctgcatc aacacctgca aacggttcat ccataaaata aatgtcagcg ttctggcaga 2560621 gtgcccgggc aagaaacacc cgctgctgct gtccgcctga cagctggctg atttgccttt 2560681 tcgcataatc atgcatcccg acttttgtta atgcggcctt cgccatctcc acatccgctt 2560741 tctttggcct ctttaataaa ccgattctcc cgtatcttcc cattaggacg acatcgagcg 2560801 ggcttgtggg gaaatcccag tcaaccgagc cgcgctgcgg aacatatccg attctggtcc 2560861 gctgatcctt atagtctttg ccgtaaatag agatgtctcc ggaagctctg ggcacaagac 2560921 cgagaatcgt tttgatcaag gttgattttc ccgcgccgtt tgggccgata atgccaataa 2560981 gttttccttc aggcacctgc agcgaaatgt cctgcagtac aggcttttta tgataagcaa 2561041 ccgtcacatt atcaagctca acagggaaca tatcctccac ctcttttctt tatttaagcg 2561101 ctttagtaat cgtgttgata ttgtggcgga acattccttc gtatgtgcct tcttttgtgc 2561161 ccttttcacc catggcatcc gaataaagct gaccgccgat tgtgactgta tggccttttt 2561221 ctttagcgcc ttccaccact gcattgattg atttttcaga tacactgctt tctacgaaca 2561281 cagcttttat ttgtttttct gtcagaagat caaccagctc ctgaacatcc cttaatccat 2561341 agtccgaatc tgtgctgagt ccctgcaggc cttttacctt aaatccatac tcattcccaa 2561401 agtacgcaaa cgcatcatga gcagtcacaa gcacacggct tttctccgga atatgtgcga 2561461 tctccttacg cgaccactta tctaaatatt gcaaatcttc tttgtactct ttggcatttt 2561521 tccgaaaggc atctgcgtgc tgaggcattg ctttgctgaa ttgcgcttca atttcatcca 2561581 ccgcatagat ccataacgga atgctgaacc agacgtgggg atcaaacgtc ttgccttccc 2561641 ccgcgggaat aagcttattt ttcggaatgg cctcagctac tgccgccgat tgtttttgtt 2561701 cgccgatttt ttggaggaca tcctccattt tcccttccaa atgcaacccg ctgtacagaa 2561761 caacatcggc agacattaat tttttcgtgt caccttggga agctttgtaa aggtgcggat 2561821 caacccccgg tcccattaaa gaggtgactt ttacgtgctt acctccgatg ttttctgctg 2561881 catcggcaat ttgagatgtt gtcgctgtca cttgtaattg ctgatcagcg ctttttccgg 2561941 ctgaatccgt tccgcatccc gttaaagcaa aggtcgcaaa aagtactgct gccatcagcc 2562001 cttgtctcat atttctcctc ctctttgcca tcaatgtccg attgttttat cttatgttgt 2562061 cagttcttag acatgtgaca ttaaattagc caaaagcatg ttttatttac acaggacaaa 2562121 aagtttccct catgcaaaat tatcgcgttt ggccattttt gtcaagctga tttacataaa 2562181 aaaaccggct gggtcagcag ccggtccaaa cgagaaggga tgtattcaac gaacactttt 2562241 actgtaacag cacagtgtca tttattcaaa atagcaaaat gcttttttct taaccatgct 2562301 gtgtgaaaac atccattttg gtcacatatt ttcgcataat atcttggttt acctcaaccc 2562361 ctaaaccagg ctgttttgac acagaaataa atccattatc aatacgaata tcaggagtta 2562421 caatatcttc atcccaatag cgtgaggatg aagatatatc gccaggtatt gtgaattgag 2562481 gcagtgaagc aagcgccacg ttctgcgctc ttgatatgcc tgtttccagc attcctccgc 2562541 accaaacctg catatgatgc tctttgcata aatcatgaat ttttaaggct tctgttaagc 2562601 cgccgacacg agaaggtttt atattaataa ttttgcagct tcctagctca atcgcccgtc 2562661 tcgcatcatc aactgaacaa atgctctcat caaggcaaat ggccgttttc aaatgtttct 2562721 gcaagtggcg gtggtcaacg atatcgtcag cttggagcgg ctgctcaatc atcattaaat 2562781 gatagtcatc aagctccttt aaacggctga tatccttcag ttcgtaagag gaattggcat 2562841 cggccataag cgggatggtt gggaatcggc tgcggatggc cttgaccaat tccacatcct 2562901 gcccaggctg aattttaatt tttattcttt gataaccttc tttttgatag ctctcaattt 2562961 ccttcagcat atcgtcaaga ggcgccaggc cgactaccac cccggcaggg actttatctc 2563021 ttgttccgcc caatgcctca gcaagggata cgcccttctt tttggcataa atatcccata 2563081 cagccgattc aagtcccgct tttgccatcc ggtttccttt ataccgcgcc aggctgtccg 2563141 gcacttctga agggtgattg aattcacggc cgacgacatt tgggataaaa aaatctttta 2563201 gcatatgcaa acatgttcca atggtttcct cggtgtacca aggcgaagag aaagcggaaa 2563261 cttctcccca gcctgtgaca cctgatgtat caatggcttc cacgatcaga aatttacgct 2563321 cttgaagcgt ttcgatactg tttttaaacg gtttctttaa gttcatgctc aaatggtaaa 2563381 gcgtgatttt ttctatttcg atcatagcag ttctccttta cgcgcatcct tcagctgatt 2563441 tcgcaagagc ttattagacg cattgcgcgg caggcggtca agcacaaaga attttgccgg 2563501 aattttatac ttcgccaagc gttctttgca gtagtcagtc aattctcctg cgctcacagg 2563561 cttgtgaagg acaagatagg cgtgaggcac tttcccccat tttttgtcct cagcccctga 2563621 aaccccggct tcggccacag cggggtgtga aagcagcact gactccactt cggccggata 2563681 aatgttttct ccgccggata tgatcagatc tgaacgtctg tctaatacat ataaaaagcc 2563741 ttcattgtcc aaataaccaa gatcacctgt tttcagccag ccattttgaa aggaggcttc 2563801 gtttgcgctc tcccggttaa aatagctttt catgacattc gggcctttga ccatgatttc 2563861 accgtgttca tacggttcac atacctgtcc gtcccgctct attttgattt cacacgaaaa 2563921 cagcggtttc cccgcagatc cgagcttttc catgctgaat tccggcgaca gggtaacaat 2563981 ttgcgagcat gtttctgtca ttccatatga ctgaaagaca gggaatcctt tctcacggca 2564041 ttcctcaagc aatggcagcg gtgcaggacc gccgccgaga agaatgcatc tgatggattc 2564101 agggcagcgg tttgtttctt ccaaaagact ggccagcata gtctgcaccg cagatatcat 2564161 tgtcacttca tgcctgttga tagaatgcag cacatcgctt acggaaaaac gctggtgaag 2564221 cacgacagtc attccataga tcacagattt aaataatgcg gacaatccgc tgatatgaaa 2564281 gagcggcaat gcgataagcc agcggtcttg ttctgttata cccaaattaa gagcggacga 2564341 caccgcactg aaataatggt ttccgaacgt ttgctgaact cccttgggct ttcctgtcgt 2564401 acccgacgta tacatcagcg ttgccgttgc atccatttgc atataagcct cgatctcaat 2564461 ttcctctgct gcttctttca tcagttcatc cacatcaatc gtttgaacga tgtgttcata 2564521 ttctttcttc tcaaagcttg aatctgtcaa taaaaagccg gatcccgaat cctccagctg 2564581 aaacagcctt tcatgtgttg acagcttcgt attcaaaagc accgccttaa caccaagcaa 2564641 aaaacaagcg tgaacagcgt ataccatttc tgcacggttt tggagcaaaa tagctgcagt 2564701 atcccctttc cgaaccgaat gagcggcaag ctgttccgcc attcgtttag acgcggcaaa 2564761 caattctgca aatgtcacgg tttggtcttc atagatgaga gcgattctct caggtgtcag 2564821 ctgtgcccgc tgcatgagcc agttgggctg ttctgtcagc atgtcatcat ctccgaggta 2564881 aaatgtctgt attgaaaaga aaacagcttg gaccgcaaag tctcaagctg ttggtttact 2564941 agatattgct gatcacggaa aacgagggaa ctgtccgaaa tcaggtttgc gtttttcctt 2565001 aaaggaatca cggccttctt ttgcttcatc tgttgtgtag taaagaaggg tagcatcccc 2565061 tgcaaactgc tgaattccag caagtccgtc tgtgtccgcg ttaaacgcag ctttaagaaa 2565121 gcgcagtgcg gtcgggcttt tttcaagcat ttcttcacac catttaatcg tttcttcttc 2565181 aagctgttcc aaaggaacga ctgtgttgac aagacccatg tccagtgctt cctgtgcgtt 2565241 gtactgacgg cataggtacc agatttcacg tgctttttta tgtcctacaa ttcgagccag 2565301 gtagccagaa ccgtaacctg catcgaagct tcccacttta gggcctgttt gtccaaaaat 2565361 tgcgttgtcc gcagcaattg tcaagtcaca tacgatgtga agcacatggc ctccgccgat 2565421 cgcatatccg gacaccatcg caacaaccgg tttcgggatg acgcggatta aacgctgaag 2565481 atccaatacg ttaagacgag ggatctggtc gtctcctaca tatccaccgt ggccgcgcac 2565541 tttttggtct ccgccagaac aaaatgcttt gtcccctgca ccggcaagca cgataacccc 2565601 aacgttttgg tcgtctcttg cgtcagcaaa cgcatcaatc atttcagcaa ccgttttagg 2565661 ggtaaacgca ttatgtacct caggtcggtt gattgttatt tttgcaatgc cattatacgt 2565721 ttcatacaat atctcatcgt atgtccgttt tgttttccat tcagccatat gatgacctcc 2565781 ttttattctc tatgtgaatg agtcagatgc ttgtcaaaaa ctcactcact attttaccaa 2565841 acaatcgcgg ctgctccaca tggaccgtat gtcctgcttt tggaacaatc tctattctac 2565901 tagaaggaag catcttatgc acctcttgat tgatggcgca aaatttttcg tcccactccc 2565961 cgcagatcag aagcacagga acatctattt cctctacacg gctccacaag gaaggctgtg 2566021 aaccggtgcc catgccggtt aaactgttcg caagcccaat cttattgttc cgcagacggc 2566081 ccgatcgtat cctgtaccga atatcttcag ccagcctctg ctgagatgaa aacaaaggga 2566141 tattctccca atacgcaaca aacgcttcga gcccgtctcg taaaataaaa tcagcaagct 2566201 tccggtcccg catgattcgt tcccgccgtt ccccaagtgt tttgagcccc ggcgtcgtgc 2566261 tttcaagcac aagtgccgat acccgctcgg gatatgtcat cgcaaaagag taagcaagcc 2566321 ttcctcccat agaataccca atcaatttca ctttgtgaag ttttaattga tcaaaaatct 2566381 cggcaaggtc agaaacttgc cgggttgtgc tgtatctttt cccattcagc ggggcatcgg 2566441 tttccccatg ccctaaacaa tcaattttga tcaaacggga atcaggcagc atttcatcaa 2566501 gaaaagtcca tgattgtttg ctgccggtaa acccatgcag acagacgacg gcttcggaag 2566561 cattcggtcc ctcgtctgcc actgcatatc ggacaccatc tgataccgtt atgtttacag 2566621 ttcccattgt tttttcactt cccgcacagc ctcattcagc atatcgcgat gaagctggac 2566681 tcttgattgg cgatccgttt tgatttcaat caaatggagt ccgggcttgt ctgcctgcgg 2566741 cgcgtaagct gttttgaatt catcccaaga agccgggcat gaatacgttc cgccgtaaag 2566801 tgcagccgca tgcttgaaat cgagccctgt cggtgtgccg aacaaatctt caaagtgtgt 2566861 cttctcagaa gcctgcggca aaaaggagaa aatccctcct ccgtcattat tgacaagaat 2566921 cacagtaaga ggaataccca gctttttggc cgccagcagg ccgtttaaat catgataaaa 2566981 agataaatct ccaatcacaa gggtaacagg cgcttttgtt ccttcacata cccccatggc 2567041 agaggagacg acaccgtcta tcccgtttgc tccccggttt gaataaatcc ggaaagggcg 2567101 gtcctgcttt tcaaaaaacg tatcaacatc cctgatcggc atgctgtttc ccacaaacag 2567161 cgagctgttt tcaggcacaa gatgctgaag gattcgatag agattgcctt caaacgaaac 2567221 atcttcactg ctgattgttt gcagatgctc gcggaaccgc ccattgacaa actgccactt 2567281 ttccagccac tctgaggatc tggtggcagc agtaaggcct gccatgatct cctcagcaaa 2567341 aacagacgca ttacaatgaa tcatatgcgc gcttgcctgt gtcgggtctc tccaccctcc 2567401 atcctcgtca atcacgattt gctgaatcgt cggatcatcc ttaagccata agaaaaccgg 2567461 ttttgaaaca ggcatcggtc caaaccgaat gacaacatca ggacggagtt tccgcttcag 2567521 ctcatcatct tttaaaaacg aatcatacgc atcaataaca gtgcttttat catgaacacc 2567581 attccgcaga ttagacagcg gatctgctaa aattggatac tgaagcgctt ttgacagcgc 2567641 aataatgttt tccttgtccg catcactatg gagctctccg cagacgatca ttcctttttc 2567701 agcctctgcg agcatctcag ccacatcaga cagggactct cggtcaacag actgcgtacc 2567761 cgttttcaca gacacatgac ggcctgttct cattcttcca aacggctcat ctgaaagatc 2567821 cggcatcagc ggttcgcgca gcggcacatt cacatggaca ggccccatcg ggcgcttttg 2567881 tgcttctccg gcagcgcggc ttgccagcgt tcggatgtat ctcagcattt gcggagactc 2567941 ttcaggaaga gcagagtctg tgaaaaactt aacaaagtta ccgaataaga agtgctgatt 2568001 aatagcctgc ggtgcgccta cttcgcgcag ctcatgaggc cgatcagcag ttaacacaat 2568061 aataggcacc cttgaataat gggcttcaac cacagccgga taaaagttgg ccgcggctgt 2568121 tccagatgta cagatcaata gtacgggacg ctgcttcgct tttgccaaac ctaatgcaaa 2568181 aaatccggca gacctttcat caatttggac atggacgctg atatcgggat gcgcagcaca 2568241 aagaacagcc agcggtgtag atcttgagcc cggacaaacg acggcgtccg taattccgga 2568301 aagggcgaat tcatcaataa aacttccgat gtaatgagta atcgggttga ctgtcaacgc 2568361 ctctcacctc ctaatgcaga gatcatcggc ttcaatttaa tctgtgtttc ttcatattcc 2568421 gagattggtt ccgagtcttc cacaataccg cacccggcaa acagccttgc tgtgcttcct 2568481 tcgatgagcc ctgaacgaat ggcgaccgcg aattccccgt tatcctggct gtcaatccag 2568541 ccgatagggg ccgcatacca gccgcgggac atcggttcaa tctccctgat cacgtcaaca 2568601 gctttttcct gaggtgatcc cccaagcgcg ggagtggggt gcagcttctc aattaagtca 2568661 aaaatcgaag cagactcgcg cagctgtccg acaatcggcg taaacaggtg ctgaacgctt 2568721 tttgttttgt acaaaacagg tccatcaggc ttttcaacct ctgaacagct tgatacaaaa 2568781 gcattatgaa tcatacctac cacaatatca tgctcaagca ggtttttctc atcgtttaat 2568841 aattcaaggc ctatccggcg gtcgtcttct tcattcacgc ctcgtttaat ggagcctgcc 2568901 agacaggaag acatgacagt gccgccgtct cttttgatca gtctttccgg agacgcgccg 2568961 acaaaggttt tgccttcttg ttcaattgca aaaacatagc ttgtctgctg atcgtccaga 2569021 agcgttttaa gcaccggttc aatttggatt ggaccgtcaa acgtgagcag cagctctcgg 2569081 gcaagaacaa ccttatcata ttgtttctct ttaatttggc ttgtggccgt ttcgattgct 2569141 ttcagccaat catccttatc cagctcttcg gctgctgcaa tcacagcctg atcttcttgc 2569201 ttgaaatcgg gaaccataaa ttccgccgca aaagctttta agccttctaa aacagcttct 2569261 gcgtcttctc ctccgcttac ccatctgtta actgttaaga acgggccttc agcagtcatc 2569321 gtcagcataa gcgcaggcac aaagaaatcc ccttccgaga aatggtccca ttgtgaacct 2569381 ctttcttcgc aagggtcaaa agaaaatcct ccgaataaca caggtcccac tgcagaatgc 2569441 tgcagctttt cttcttcata aatatgaaaa gccgtctttt taaagcgctc ccattgttca 2569501 aaaacctcac gataccgctc gctgtttttt tgatttgtct ggaaaaccgc ttctttgcca 2569561 agaccgacta ttgtcaattc actttcagga tctgaccaaa aaaatcgatt gcctgtatat 2569621 ttttttgctc cgtaattgaa aaatgataga gggtcaagag actcgatttg tctcgaatag 2569681 cttattaaga cagcatggtt gacttctttg gctttatgta atgcatgtag aacttccttt 2569741 cggaacgtac gctgcaccgt tgtcaccatg agacattcct ccataatcct taaaatgctt 2569801 ttaataccat acacctgtgt ctcctttgtg tcaaacacag atcatgcagt ccaaatggcc 2569861 tgccttacct attataaacc taatttcaga aatgaaaaag aaacaaagct taaatttctt 2569921 tctccactga tagcaaaggt tgtatccgct taccataaaa ggaaaacctc ctatattcct 2569981 ccacccgcca tttatgaaag ttctcaggcg atctgttcat actaaaggta tgcatcacag 2570041 agaaacgagg cgatcacatt gcttacgaaa gaacagcttc agcatttaaa aaatgaactg 2570101 gaacaaacga aaaaagatat cttaaaccgt ttcaaagaca atgatcattt tcagcttaac 2570161 tcagcctttc cttatgattc gtggggtgag ctttcggcat acgacaacca tcccggcgat 2570221 caggcgacag aactttacga gcgtgagaaa gacatcgctc tagacttgca tgagagagag 2570281 caccttcggg acattgagca ttcattgaag gcgatagaaa acggtacgta tggcatttgt 2570341 gaagtcagcg gaaaggaaat ccctttcgaa cgacttgaag cgcttccgac tgccacaacc 2570401 ctcgcggagt attcgtcaca ggacgtggtt tccaaagacc gtccgattga agaagaaaca 2570461 ccattcgggc aatttgaatt tgatgatgat gaagaaatca gagcgccata tgacagtgag 2570521 gattcctatc aggatgtcga aaaatatggg aactcacaaa cgccgcagga tatggaaaac 2570581 cctccgctca gctatgatga tatgacgatg aatgccgaag agaatatcgg caatacggag 2570641 tcttacgaaa atttcatcgc tacagatatc actgggaaag aaattaccgt ttatcaaagc 2570701 agagcccatg agcgctatga agaagaactt gacgaagagg gaatcatgac cacattcggc 2570761 gatctccacg ctgattgaac ccccaattat tgggggttct tttccgtttt cagcatatcg 2570821 taaatcagct tcagataatc cttttgcagg ccgatgtcat accgctcgcc ctctagcaat 2570881 ttcccgtata cggtacatgc cccgagcgaa gcttttatcg catccgttac ctgcacttct 2570941 cctccgctat cagcttctaa tgcctccagc tcattaaaaa tatccggtgt gaaaatataa 2571001 cgccctgctg cggcaaaatg agacggaggg ttttgtttag gcttttccac aatatcctgt 2571061 atgcgataaa gccctttttc aacaggctcc ccttttatca ccccgtaatg atgtaaatcc 2571121 tccgtttttg tttcttttaa gccgatcaca ctggactgat atttcgtata cgcttcaatc 2571181 agctgcccca aagccggctg attggcggaa aaaatcagat catctggcaa aacgacggca 2571241 aaaggctctc ctcctgcaaa ttgctttccg aaagaaatgg cgtcgccaag accctttgca 2571301 taaggctgcc gcacatagtg aatccgtata tccggaatgg gatgctctct aagtaaatgc 2571361 agtttattct tagaggccaa aaaagcctca agtgccaaag aggaatcaaa atagtcgaca 2571421 atcagatttt tatggctcga tacaaccatc aaaatgtcct caatgcctga ctcctttaat 2571481 tcttcaacaa gataatgaat cacaggctta gatcctaccg gaaacatttc tttcggaatc 2571541 accttcgtca ccggcagatt tctcgtgccg aatccgcctg caggaatgat cgcttttttt 2571601 atcatggtat tttcccctca gctcatgttt attacatgat attccaagag cgcatcccga 2571661 tgtttgtaca tctgaaatta ggcggaagca actgggcaga aagcggaatc acgaaccagc 2571721 ccttttttaa taggatattg atatatgacc agtaatcttg taaaggagct caggtgatga 2571781 aaatttgtgt ggttggcgcc gggtatgtcg gtttaaccct atcagcggca ctggcatcca 2571841 tcggacatga catgatatgc acagacaaag acgtcaaaaa aatcgggcag ctgaaaaaag 2571901 gagtcattcc cttttacgag cctgggcttt cagatgcaat acttcgttgc ggcaatctct 2571961 cgttttcttc tgaagtgaaa tcgagcatgg aggaatgtcc cgttattttt atcgcagtcg 2572021 gaactccgcc gcgttcggac ggatcagctg atacgaaagc cctgcagtcc gtcatcggtg 2572081 atttaagcga ggcgatccga tcgtataaaa ccattattac gaaaagcact gttccgcccg 2572141 ggacaaatga aaacatagca aaacagctga ttgcctccgg agtgtctaaa aacctcttta 2572201 atatcgtatc caatccggag tttctgcggg aaggcaatgc cttatatgac atgctgcatc 2572261 ctgacaaaac agtcatcggt gttcaggaag aagatcacgt atcggcagcc atcgtcaaat 2572321 ccatttacaa acacattgat acccctttta tcgttacaag cttagcggga gcagagctga 2572381 tcaaatatgc caacaatttc tttttagcgg ccaaaatttc gttcattaac gaaatggccc 2572441 gcatatgtga agcctatcaa tcagatatct cagatatttc ccgcgctatc ggtctagacc 2572501 caaggatcgg gaagcacttt ttgcaggcag gcatcggata cggaggctct tgttttccaa 2572561 aggatctgca ggcgctgcaa tttgctgccc aggaaaaaaa cacggagacc ttcctgctcc 2572621 gggccgtgca gcacattaat gacacccagc ttggcctgta tatcaaaaaa atacagtcat 2572681 tcttcgaaac acttcaaggc aagaaagcgg ctgtactcgg catttccttc aaaccgaata 2572741 ctgatgacat ccggaattct caggctgtca gactgatgga aaggctggcg gagctgggat 2572801 gtgatgttca tgcatatgat cctgaagctg tacttccaga acatttgcgg caacatgtaa 2572861 ctcagcattc tcaagctttt gatgcgatcg aagagagtga ctttttattt ttggcgacag 2572921 aatggtctga gtttttagcg tttgattgga aaaaggctgc agatatcatg aaagggcgtc 2572981 ttgtgattga cggacgcaac gtactaaaaa aagaactgat cgaggcttgc ggcctgatct 2573041 gtacgggagt tggccgtcca tgaaaatact cgtcacagga gcagcgggct ttatcggctc 2573101 ccacctctgc gaagaattac taaaagataa gaaacataac gttatcggaa tcgatgactt 2573161 tatcggtcct actccatttt ccttgaaatt aaaaaacctt aaaaacctgc tgccggaaaa 2573221 gcgatttacg ttcataaagg aaaatctgct gacagccgat cttgcttcct tactggaagg 2573281 agtggacgtc atctttcatt tggcggccat accgggtgtc cgctcaagct ggggcaatca 2573341 ttttcaccca tatgccgcac ataatatcca agcgctccaa aggctcctcg aggcgtgccg 2573401 ggaacattct attcaaacgt tcgtctttgc atccacctct tccgtctatg gcgaaaaaca 2573461 aggaaaagtc agcgaaaaca cgtcgctttc tcctttatct ccgtacgggg taacaaagct 2573521 tacgggagaa aagctttgcc atgtgtataa acagagcttt ggcattccaa ttgtgattct 2573581 ccgttttttt accgtatacg ggccaagaca gcggccggat atggcttttc accggctcat 2573641 taagcagcac cttcagcaaa agccgcttac catcttcggt gatgggcagc agtcaagaga 2573701 tttcacttat atcagcgact gtgtcaaagg catcaccgct gttcttggga aaccccacct 2573761 tattggtgaa acagtaaata tcggcggcgc agagcgtgcc tcagtcttaa aagttgtctc 2573821 cctcattgag gatatttccg ggagaaaagc aacactgcac ttttcggaca aaatagcagg 2573881 ggaaccgagc aacacgtggg cggatatttc aaaagcaaaa cagctcttgc attatgatcc 2573941 cgccacatcc ttaaaggatg gcttgaccaa cgaaatcgcc tatttatcgt cgctgtatca 2574001 gggggaataa aaatgaagct tgcctttatc tgtacagaaa agctgccggc gcccgcagta 2574061 cgcggcggcg ctattcaaat gatgattgac ggtgtcacgc cctatttcag cagcaggtac 2574121 gacctgacca ttttttcaat agaagatcca tcgctcccaa aaagagaaac aaaagacggc 2574181 gtacattata tccatctgcc aaaagaacat taccgcgagg cggtagccga agagctgcga 2574241 gcctcttcct ttgacctcat tcatgtgttc aacaggcctt taaatgtctc tttatataaa 2574301 aaagcctcac caaacagcaa gatcgttctg agcctgcata acgaaatgtt ttctgaaaaa 2574361 aagatgacct tcgcgcaagg aaaagaagta ctcgacaatg tctccatgat cacaacagtg 2574421 agcgaattta ttaaacaaac cgtcattgaa cgtttccctg aagccgagga catcacaaaa 2574481 gttgtgtatt ccggcgttga tttaaactct tatccgcccg tctggacgat gaaaggctcg 2574541 gctgtcagaa aaacataccg gaaaaaatac ggtattgaag ataaaaaagt tattttattc 2574601 gccggccgct taagcccgac aaaagggcct caccttctca ttcacagcat gagacggatt 2574661 ttgcagcagc accctgatgc tgtactggtc atagcaggcg ggaagtggtt cagcgatgac 2574721 agcgaaaacc aatatgtcac ctatctgcgc acgctggcgc tgccatacag agaccacata 2574781 atctttacaa aattcattcc cgcagacgat atcccaaacc tttttctgat ggcagatgta 2574841 tttgtgtgca gctctcagtg gaacgaaccc ctcgcccgtg tgaattatga agcaatggcg 2574901 gccggcacgc ccttaattac cacaaaccgg ggcggaaacg gtgaagtcgt aaaacacgaa 2574961 gtcaccggcc ttgtcatcga tagctacaac aaaccttctt catttgcaaa agcaattgac 2575021 agagccttta cagatcaaga attaatgaac aaaatgacaa aaaacgcccg aaagcatgta 2575081 gaagctttat ttacctttac ccatgctgcc aaaaggctca atactgttta ccaatccgtt 2575141 ctgaccccga aaaacaaaca atttccgccg ccttttctga cgcaaaattt tgatttatca 2575201 tctatcaatc agctttttgt gaaagcaaaa acataaaacc tacagctcgt gttgcaaaac 2575261 gggctgtttt ttcgctacag agaacttaaa aaaaggcata aatgtgactt tatgccttgc 2575321 gctttacagt ttgagaaaac catggagctg gtttagattc acttggaaga atgatgattt 2575381 ccactttagc ttcttccgct aagtctggtt cttcatcttc atcctcttct tcatatgggg 2575441 gcgctgagcg tttcgaatca cgctcctcct caggctccag agtggtttcg aattttgttt 2575501 cttcttcatc atcgacgatt ttgcgatctg tttccttttc cttcgtttct ttttgatatt 2575561 ctttcggtgc attgatgtga gggagctctc gaatgctgcc cacatctaaa tgcttctcct 2575621 cttcttcctt ctcagctgag attgagtcat gagcctgcca tcccatcggt ccaggcggtg 2575681 taaatacgaa ttggtcgaga tccagtttag aaatagaggc tttttgtctc gatgacctca 2575741 tgtcaattcg cctcccgata cgcttttatc tttttataca gttccggcag tttatccaaa 2575801 aacgaatctt tagattcttc aacagaaatc atgttttgca gcgcccagtt atacttctca 2575861 tctgaccacg ttttcttttg cttcaaataa tatttgtgcc cgattgcaca gaacaaatgc 2575921 ggaaacgcga gatcaatcca aagtacctcg tactgttttt ctgtgagcgg atacactgcg 2575981 tcgtaggccg caagcagtgc aaccatgaaa tcagtatccc atacagaaag cttaaccatc 2576041 actttattca gcagaatacg aaggtctctt gacggcaaat cgtaggtaat cgagtgaagc 2576101 tcctttaaaa aaggctcccc ttcgatctca gtcaaacgtg ccaatgtaaa atcctgaaaa 2576161 cagaatccgc catgctcgag tgtctctttt gtccaggttt cgtattctga gtcatcaagc 2576221 gctctgagag cttcttttcc tcttgccagc attttatcag catgttttaa gaaagtttgc 2576281 gaaaatacgt catcaggata ggatgctgcg atctgcatat tcccttcaag ttcctgcagc 2576341 ttccaacggt acaatttgtg ccattttccc agcctgcttc tcttcttgct ttcatctgtg 2576401 caaacatatc cttttgaggc atgatgaaaa tggccggcaa atgacatgac ttttttcatt 2576461 tgctctgcat catagtaaat catttctttt cctgtcactt tgtcatataa actgtaagaa 2576521 acctgatccg tgcccaagca gctaccgcca ttttttgttt gatgaatcgg cgctatcggc 2576581 agccctttct cttgtaaatg ggcgtgtgcc tgagtgataa aaagcatccg ctccggtttc 2576641 atttgcgctt cttttagcag ctttgggcca tgatcagttt cgacttccca gattttgcgc 2576701 ccgcttttgt tcgatttcag cgccacatgg tcgatatgaa acggataata actgagaatt 2576761 tcggacacaa tctgttcttc atgctctttt tggtacactc tgttcacccc ttctatctgt 2576821 tcttttcata gacgctgagc agattttcag ccaccctctg ccagccaaaa ttgctttctg 2576881 cctcacggcg gctgtatttc ccaagccgtt cccgcttttc cgagctgctc agcaaatcat 2576941 tgatacgttc ggcatattgt ttaggatttt caaagtcatg aatgatgtag ccgtttttcc 2577001 cttcctctat gacctctgga ttgcctcccc gattgcttgt aataatagga agtcccgcag 2577061 ccatcgcttc ataatgcacc cttgctaaag gctcctgcca ttgcgaagag catacaaata 2577121 catctgacat ggtataaagg cgcggaatgt cctttggctt cacaaattga ataaatgtga 2577181 catgatcctt ttgcatcgca ccaagggtat gaagatgttt gacatagtta tttaattcat 2577241 tatctccgaa ccattttgac ccgataaaca ccatcatgac atcggggtgc tcctcaatga 2577301 tgtccggcaa agcctgcaat aatatgtgcg ggcctttgac tttgctaagc cggccgacaa 2577361 acaagacgat ttttttgccg tgaagcccca gctcgcttcg catctcttcg cgagctcgct 2577421 gcccttcatt cgtccagcga gggtggtacg tttttaaatc cacaccagaa tacaccgttt 2577481 ttgtttttga tcgtgctgac ggaaaacggc ttgtgatcgt ctgtccgata taatcgctga 2577541 ccgtaacaat ctgcgctacg gagtcgatgc aaatctcgcc ttccgcctgg ctgattttat 2577601 cgtaagcgaa catttcattg tgaacgctta aaataaaaac agcatccggc gcctgtttct 2577661 tcaatttcgg aacccagctt gggcgattac aaacatgcac aagatcaaaa cggctctttt 2577721 tcagctctgc tccaacggct tcttcataac ggtcttcatc caaatgcaca taatggacac 2577781 cgtctacctt ctctctatca gcgagattcg gatctttaat agaaaacaca gtcacctcat 2577841 gtttttttgc aattaaaggg gcaaccgctt cgaggtagat ttgaatggcg cctcctcgaa 2577901 ccgatgggac aggaagcttc tctgtggcga tcagtgctat tttcatacat agcctccatt 2577961 cctgcatgat ttttaactag ttagaatcat gatacggctg aacaaccaac ttgtgcggaa 2578021 tgggactgcc ctaaaaacaa aacgggtaaa caaccagatt catctattaa atatagtcaa 2578081 ataactcaat cattttttcc ttttgattca taaggtagga gtaaaacagg taaggatgtg 2578141 tcctttaatg gcagaaaacc atgaagtcat tgaggagggg aattcatcag agcttccttt 2578201 atcagcagaa gatgcaaaaa aattaacgga gctggctgaa aatgtgcttc aaggatggga 2578261 tgtgcaggct gaaaaaatag acgtcattca gggaaaccag atggcgcttg tctggaaggt 2578321 ccacacagac tccggcgcgg tttgtctaaa acgaatacac aggccagaaa agaaagcgtt 2578381 gttttccatt ttcgcgcagg actatttagc aaaaaaaggc atgaatgttc ctggcatact 2578441 cccaaacaaa aaaggcagcc tatattctaa gcacggctca tttctatttg tcgtatatga 2578501 ctggatcgaa ggaagaccgt ttgagctgac tgtaaagcag gacttggagt ttatcatgaa 2578561 aggccttgct gattttcata cagcttccgt cggatatcag ccgccaaatg gcgttcccat 2578621 atttaccaaa ttaggtcgct ggccgaatca ctacacgaaa cgatgcaaac agatggaaac 2578681 gtggaagctg atggcggagg cggaaaaaga agatcctttc tcacagcttt atcttcagga 2578741 gatagatggc tttattgaag acgggctgcg catcaaagac cggcttttgc aatcgaccta 2578801 tgttccatgg actgaacagc tgaaaaaaag ccctaacctt tgccaccagg attacggaac 2578861 cgggaataca ctcttaggag aaaatgaaca gatttgggtc atcgacttag ataccgtatc 2578921 atttgatctg cctattcgcg atttgcgcaa aatgattatt ccgcttttgg atacgacggg 2578981 tgtttgggat gacgaaacat ttaatgtcat gctgaacgca tacgaatcca gagccccatt 2579041 aactgaagaa caaaaacaag tcatgtttat tgatatgctg tttccttacg agctttacga 2579101 tgtcattcgc gaaaaatacg tccgcaagtc tgctttaccg aaggaagaat tagaatcagc 2579161 ttttgaatat gaacgcatta aagcaaacgc attgcggcag cttatttaag accatcattt 2579221 cccccgcata tcgggggttt gatatttata agataaaggg taattaaata catgcggagg 2579281 ttgcaaatat gaaaaagatt gtcggcgctt tagccgtttt tgtgattaca tatgcgctgt 2579341 tttcagccgc aggctacctg tttcctgtgg accaagaatg gtacaattca ttgaaaaaac 2579401 cggactggac gccaagcgga actgcgatcg gcatcatttg ggccatcctg tttgccctga 2579461 tctccctttc agcagccatt gtatatgctg cgttttcatt taaaggtgcg aaaagctttt 2579521 ggtttacact tttgataaat tacgtgctca atcaagcctt cagctatttc cagtttacgc 2579581 aaaaaaatct gctggctgca tcgcttgact gcctgcttgt cgccatcaca gcaatcgtat 2579641 tactgatcat tgccaaaaaa tacagcagag ccgcaagcta tcttcttttg ccttattttt 2579701 tatggagtgc atttgcgacg ttcttatcct ttacaatcaa ttcaatgaat ctgtgaacaa 2579761 aaaaagccgc ttatacagcg gctttttcac atcatcggct tgatgcccca aatgtccttc 2579821 gcatattccc ggatcgtgcg gtcgctggag aaatatccag aatgagcaat gtttacaatc 2579881 gaatgctcag accatttcct tcgctctcga taatcagctt gaattcgctc ctgtgcatct 2579941 gcatatgagc tgaaatcctt cagcacaaaa tactcatcat tatgcggaag cagcgagtca 2580001 aagatcgatt caaattcatc tgcctctcct tcaaaaaaac cattgatcaa ctgatccgct 2580061 acctgcctga ttctcctgtc atgctgataa tattccctcg acctatagcc gccgttttcc 2580121 tgatacgata gaacctcatc cgcctttaag ccgaacgtgt aaatacagtc agggcccacc 2580181 cgctcaagga tctcgatatt tgcgccgtca tgcgtgccga tcgtcaaagc cccgttcatc 2580241 ataaacttca tattccctgt accagacgct tccttgcttg cggttgaaat ttgctcactt 2580301 acgtctgatg ccggaaaaat tcgctcagcc atagaaactc tataattttc taaaaaaaca 2580361 actttgatca gctgtttgac cgccggatca taattgactt tttctgcgac agaatggatc 2580421 agcttaatga ttttcttggc ataataatag cttggtgaag cctttgcccc gaaaataaag 2580481 gtttgcgggt agattgaaaa ccccgaatcc tccttgaggc ggttatacaa atacataatg 2580541 tgaagaacat tcagcagctg ccgtttatat gcatgaagcc gtttcacctg tacgtcgaat 2580601 atgctctcag ggttcacaac caccccggcc gtgcaaaaaa tcaaatcggc aagctcttgt 2580661 tttttcttgc ttttgttgtt ttgaaactgt tcaataaatg caggatcagt ggcgtacggt 2580721 tctaaacgga tcagtgattc cggctgcttg acccattcat cgccgatcgc ctctgtaatg 2580781 atggcagaca agcctggatt cgcttttaac agccagcgcc tgtgggcaat tccattcgtc 2580841 ttattgttaa aacgattcgg aaacagcaag tgaaagtcgc gcatctccct ttcctttaat 2580901 atatcggaat gtatttttgc aacgccattt acactgtagc tgcctactat ggccagatga 2580961 gccattttga caacaccatg cgctgtaatc gccatgttct ctatcctttt ccagtctcca 2581021 ggatactttt cccaaactgc acggcaaaac ctctcattga tctcttcaat aatcatgtac 2581081 attcgcggga gcagcggctt aaacaaatga atcggccatt tctcgagcgc ttctgacaat 2581141 gttgtatgat ttgtataaga aatcgtatgt acagtgatat gccaagcttc ttcccagctc 2581201 atgttctctt catcgagcaa aatccgcatt agctcaggca ccgcaagcgc agggtgagtg 2581261 tcattaatat gaatgctcac ttttttatgc aggccggata aagatttatg tgttttacgg 2581321 taattgttca caatgctttt taagcttgcg catactaaaa aatactgctg cttcagccgt 2581381 aaaattttcc cctcatcatg ggtgtcatcg ggatataaga attcagaaac cgcttctgtt 2581441 tctcgcttat aagacaaaat attaccgccg tgataatggg catagggctc ggcgttccaa 2581501 agccttaacg tgttgacagt gcccgtttca tagccgatga tcgggatatc ataaggaaca 2581561 gcggtaacaa ttgtcgcttg ttcatggcga aaatgcaggc gcccgctttt ttctgtcata 2581621 tggacttcgc cccaaaacgg cacgtccact gcttgatccg cattccttac ttcccatacg 2581681 ttcccgtttt tcagccattg ctcaggcagc tccacctgat gtccgtctac aattttttgc 2581741 tcaaacaaac catgcttata acgtatgccc atgccgtgcc caggcaggtt caacgaagca 2581801 agcgaatcta aaaagcaagc ggccaagcgc ccaagtccgc cattgccgag acctgcatcg 2581861 ttctctatct gaaggatctc ctctaaattg atgccgattt cctttaaacc agcttctaca 2581921 acatcacgaa caccaagatt cattaagttt tgctcaagga gctgaccgag cagaaattcg 2581981 attgataaat aatatgtctg cttcccggaa tttgatctgc ttttttcatt cgtttcgatc 2582041 caatcagcgc tgatatactc tctgaccata ttgcccaacg ttttatattg atccagcttg 2582101 gcagaatctt taaagctttt tccgcacgtc atttccagac gctttaaaaa taagtctgca 2582161 aagcgttctt tactcgagaa catcccgtcc actccttgtc acctgctcga aaatacgctg 2582221 atactcttta gccgacttcc cccagctgta atctgcattc atagcggtct tcacgatgct 2582281 cttccataca tcctgttggc aataaaacga cagcgccctt tctatcgtaa atttcagatc 2582341 atgcgcatta aaggcggaaa acgtaaagcc attgcccgtt ccctcttcct cctgataggc 2582401 acggacagtg tcgtaaagac cgcccgtttc cctgacaatc ggaatggcgc catattgaag 2582461 agcaatgagc tgccccaaac cgcacggctc aaatttcgac ggcatcaaaa acatatcaga 2582521 gcccgcataa atttgatggg ctagcggctc atcaaacccg atataagccc ggcacttctc 2582581 atgaaaagca aattctgcat accggaaata atcttcaaat tcacgttctc ctgtgcctag 2582641 cacaaccagc tgtatgtctt gctcctcaag aagttcgtgc ataattctgc ggacaagatc 2582701 aagccccttt tgtttagtga gccttgtcac catactgatc agcggaatat cgtttttctc 2582761 tggaagcccc atccgctgct gaagcttcgt tttgttttcc agcttgcatg caagatcccc 2582821 tgaatcgtat tgcgcctcta tataagggtc gcttttcggc tgatagaacg tatcatcaat 2582881 gccatttaat atgccggtta catcatcttc cctatattgc aaaacctgtt ccaactgctc 2582941 accataatac ggcgtcatga tttcatttct gtaagtgggg ctcacagttg tcacatgatc 2583001 agccgcaatg atgcccgctt tcataaaatt aacaaatccg ttgcattcta acctttcata 2583061 atgaaaatga tccatctcaa gacccagcaa gtcatgtgtg acatcaggag ggaatatgcc 2583121 ttgaaactgc aggttgtgga tcgtgagcac gcttttcatc cgttcataaa aaggatgttt 2583181 tctgtactcc tctttcagca aataattgac catcgctgta tgccaatcgt gagtatgaac 2583241 aatatcggct tgaacattca caactttggc agcctccagc acagctcttg aaaaaaaggc 2583301 aaaccgctca ccgtcatcat aatgcccgta caacgaatcc ctgttgaaat agtactcatt 2583361 gtcgatgaag taataattca catcattctc tgccatatgt tcaattccgc aatattgctg 2583421 ccgccagccg acagctacgg tacactcagc ctgttttttc atacgctttt tccacggttc 2583481 aggtatttgg ctgtacttcg gcagcatcac agctacctca ttgcctaatc gcgcaagcgc 2583541 ctttggcaga gcacctgcta catcggcaag acctcctgat ttcacaaatg gggtgcattc 2583601 tgacacagca aataatatct tcaagaattc atcagctctc cttgcaccaa accttttctt 2583661 aatacaagcg gctgctcagc tgttcctgca gcttccgtcg ccttgccgat tttaacatcc 2583721 ttatccgaaa tgacctgctc aagaagacaa tcctctccaa tctgcgtttt ttgcataata 2583781 atgcagtttt tcagcttcgt accctttccg acatggaccg ccctgaacaa aatgcagttt 2583841 tcaacctctc cttcaagcac acagccgttt gccaccaaag aatttttgac agtgctgtgc 2583901 tttccgtatt tcgtaggcgg ctcatccttc acttttgtat agatcggctg ctgcggcaaa 2583961 aacacctgct gccaaaaacg aggctgaatg agctccatac tgtgggtata atatttttcc 2584021 accgaatcaa tgacagcggc ataacctgaa tattcataag ggcaaatggt cagggcggaa 2584081 gattcctttt caacagcctc ctgaatggtt ttatagcctt tttcgctatg tccgtagatc 2584141 agatccttta aaagcgttgt tgacatgata tagatttgca gcgactggcc gtcctgaaat 2584201 acctcggtga cgtcgcagcc aacctcctga tggcgtttca gcacatattg aaattgaatg 2584261 ttgcatacgg tatggctgtt ggagattaca gcatattgct gagtgcttct gtggaagtaa 2584321 tctagatggt ccgaaaactg gcgaaaggaa ccgaattcat cgtattcgtg atgaagatgg 2584381 ggagacggga aaaaaaagag gccgtccttt ttccggtgca aatcccattc cttacccgcc 2584441 ccaaggtgat ccatgagcga acggtaacga tacttcggaa aaattgcaac actcctaata 2584501 tccgcattca ccatgttgga aagcataaaa tcaatcagtc ggtacctgcc ggcaaaaggg 2584561 atcgccccga gcgaccgctg tgctgttaaa tcctgaagag aatgcttata tgtggtttca 2584621 tctataacac ctaacatttg attattgaac actgactctg ccccctcttc agtaattaaa 2584681 tcaattcttt ttctacaaat tcctctgaaa cgagcagcac ctcttcaatg tctttttcgg 2584741 agcgaatcac tgcgccatcc ggcagcacca tcccattagg aacgatggca ttttcaatga 2584801 ctacatgctc cccaatcgtc acatccggca ttatgacgga tgatgtaaca gtcgtatgct 2584861 taccaacagt cacaccttga aaaagaacgg agtgagacac atttccatat acaacacaac 2584921 cttcgttcac aagcgaatct tgaacctgcg catcagatga aataaattgc ggaggctgat 2584981 ttggattgac ggagtaaatt ttccatttgc gttcaaacag cttcagctcc gagtcctctt 2585041 ttaacaaatc catattggct tcccacaagc tctgcaccgt tccgacatcc ttccaatatc 2585101 ccttgaacgg ataagcagaa agcttctttt tctcttccaa aagcagtgga ataatgtctt 2585161 tgccgaagtc gtggctagaa taagggtttt gatcgtccat ctcaagatac tgtttcaaaa 2585221 gcggccaatt gaatatataa attcccattg aggcaagatt gctcttaggg aatttgggct 2585281 tttcatcaaa atgtgtgatc gtcccatctg gattggcctt catgatgccg aaccggcttg 2585341 cttcctccca gcccacttcg atgacagaga tggtcacatc tgctttcttt tcaatgtgat 2585401 aatcaagcat tttgccgtag tccattttgt atatgtgatc tcctgataaa atcagtacat 2585461 actcaggatc atactgattc aaataattga gattttcata aatggagctt gccgtccctt 2585521 tataccattt gacttctgat gactcggcat aagggggtaa aaccgtcacg ccgccattat 2585581 atctatccag gtcccatgca ctgccgatcc caatatagga attcagctcg agcggctgat 2585641 attgcgttaa aatcccgact gtgtctatgc ctgaattaga acagttgctt agggtaaaat 2585701 caataatcct gtattttccc ccgaaagata cagccggttt ggccatattt tttgttaatc 2585761 cgctgagacg gctgcccttc ccgccggcaa ggagcatggc tacacattgt tttttcatct 2585821 ttttatctct cctctttttt taaccgcccg taaaatcgag atgccgtaag gggggatggt 2585881 catcgtgata taacacggtt tatgatgaag tgctcccttt ttagccgata acggcttttt 2585941 gttgatttgc cctgagcctc catatgtttc actgtcactg ttaagcactt caatgtattg 2586001 agtaaaaaaa ggaactccaa catcatattg atgatagacc acgggtgtaa aattacaaat 2586061 gatgacaagc gcctcaccgt gcttttggcc ataacgaata aaagaaaaga ttgattgttc 2586121 gtcattatgg acatcaatcc attcaaacga ttgtgcacga tggtcatgct cataaaggat 2586181 tttgcttttt tggtaaaagc ggagaagatc ttgcgtaaaa acgctggctt tctgatgcat 2586241 ggggaaggag tccaaaaacc aatcaagctg ttctgtatct ttccattcat caaattgagc 2586301 aaactctgat cccataaaga tcaatttctt tccgggatgc actgtcatat agcccagcaa 2586361 aagccgatac tgggcaaatt tctgccagta gtcgccaggc attttattga gaagtgattt 2586421 ttttccgtat acgacttcat catgagaaaa cggcaataca aaatgttcac taaacgcata 2586481 tagtaatgaa aaagagataa gctgatgaca atgccgcctt tcttcgggcg gcgtctccat 2586541 gtatttcagt acgtcattca tccatcccat attccattta taatgaaaac caagcccccc 2586601 ttcctcaacg gcacctgtca cttgaggcca ttctgtagaa tcttctgcaa tcatcatcac 2586661 atggggatat gcctctctca tggtttgatt gagttttttt aaaaaatcaa cagcatatgg 2586721 attcgtgtgg cgttcatcct gatttggcca atacaagata ttagccactg catcaaccct 2586781 aaatccatct atatgataga attccgccca gtacaacgca ttcgaaatta aaaaactatg 2586841 aacttccggt ttccccaggt caaagtttgc cgtgccccat aaccagttct cccgatcacg 2586901 ttcttctttg tattcataaa gcggttctcc atcaaacata taaaggccat gtgcatcttt 2586961 acaaaaatgt ccggggaccc aatccaaaat gactccgata ttttgttgat gacattcatc 2587021 cacaaacttc atcagatcat gcggcgggcc aaacctgctt gtcgggctgt aataccccgt 2587081 tccttggtac ccccatgaac gatcatatgg atgctcatac acgggaagca gttcaatatg 2587141 ggtaaaccca tgcttcttga tataagggat aagcgtctga cttaattctt tataggaata 2587201 atgcctgcca tcagaatgct tcttccaaga cccaagatgc agttcataaa tgaaaacagg 2587261 tttttcatac agcgtcttag ccttctgttt cttttgccat ttttgatctt gccagctgta 2587321 tccttccaaa tcgtaagtaa gtgacgctgt gtttggtctg acttctgaat aaatagcgta 2587381 tggatctgcc ttcagcctga tctcaccgtt attcgtcaca atttcgtatt tatatcgttc 2587441 cttttctcct atacctggaa taaataacgt ccaaatgcca ttatcattca ctctgtgcat 2587501 cacatgctct tctccagacc agctgttaaa atctccagcc actcgtactt ccgacgcatg 2587561 aggcgcccac acacagaatt catatccgct tttgccattc agctcgcggt aatgcgagcc 2587621 aaacagctga tagcttttaa acagactgcc ttcgtgaaaa agataaacat catgtgctgt 2587681 cgggctggca gcggccatgt aatcatcctt tctgacatca tagttttcat ttatagtatt 2587741 tattcgaaga aataaaaaaa agccctttcc tgaaagcgct tatacttata gacaattaac 2587801 ttcattttct gaagaaaaac gaaatatatg gagatttttg tagtctgttt ttaaaataaa 2587861 gaacaaaatc taagacatat catgatttat aaaaacaaaa aaaccttgca ggatatgcaa 2587921 ggcttctgga tgacccgtac gggattcgaa cccgtgttac cgccgtgaaa gggcggtgtc 2587981 ttaaccgctt gaccaacggg ccgataatta tgatatctgt aatcatatgg cggagaagga 2588041 gggatttgaa ccctcgcgcc gcttacacga cctacaccct tagcaggggc gcctcttcag 2588101 ccacttgagt acttctccat ttggctccac aggcaggatt cgaacctgcg accgatcggt 2588161 taacagccga tagctctacc actgagctac tgtggaacaa aagtcatggt gggcctgaat 2588221 ggactcgaac catcgacctc acgcttatca ggcgtgcgct ctaaccagct gagctacagg 2588281 cccatgacga tatagaaatg gagcgggtga tgggaatcga acccacgaca tcagcttgga 2588341 aggctgaggt tttaccacta aactacaccc gcaattttta tttggggcga ttgatgggaa 2588401 tcgaacccac gaatgccaga gccacaatct ggtgcgttaa ccacttcgcc acaaccgcca 2588461 aagcatattg ataaatggtg gctcgggacg gaatcgaacc gccgacacac ggattttcag 2588521 tccgttgctc taccaactga gctaccgagc ctaagtattt aaatggcggt ccggacggga 2588581 ctcgaacccg cgacctcctg cgtgacaggc aggcattcta accaactgaa ctaccggacc 2588641 attttaaaat ttggttgcgg gggcaggatt tgaacctgcg accttcgggt tatgagcccg 2588701 acgagctacc gaactgctcc accccgcgat gattaggaat atgtatggcg gaggaagagg 2588761 gattcgaacc cccgcgggct ttgacacccc tgtcggtttt caagaccgat cccttcagcc 2588821 agacttgggt attcctccgt atagtggtgg accttgtagg actcgaacct acgaccggac 2588881 ggttatgagc cgtctgctct aaccaactga gctaaaggtc cattggtagc ggcggagggg 2588941 atcgaacccc cgacctcacg ggtatgaacc gtacgctcta gccagctgag ctacaccgcc 2589001 aaatattttt gaaatcaagt ggagcctagc gggatcgaac cgctgacctc ctgcgtgcaa 2589061 agcaggcgct ctcccagctg agctaaggcc ccaagaatgg tcgggaagac aggattcgaa 2589121 cctgcgaccc catggtccca aaccatgtgc tctaccaagc tgagctactt cccgatttca 2589181 tatagatcat ggcgcgcccg agaggagtcg aacccctaac cttttgatcc gtagtcaaac 2589241 gctctatcca attgagctac gggcgcaaaa cttaatgccg agggccggac ttgaaccggc 2589301 acggtagtca cctaccgcag gattttaagt cctgtgtgtc tgccaattcc accaccccgg 2589361 cgtggatggt atagttggag cggaagacgg gattcgaacc cgcgaccccc accttggcaa 2589421 ggtggtgttc taccactgaa ctacttccgc agaaatggtg cggatgaagg gacttgaacc 2589481 cccacgtctg taaagacact agagcctgat tctagcgcgt ctgccaattc cgccacatcc 2589541 gcaacatgta aatggtgagc catgaaggac tcgaaccttc gaccctctga ttaaaagtca 2589601 gatgctctac caactgagct aatggctctt cttacaatag acttgaatat tatatcatat 2589661 aaaagtggtg ccggcaagag gacttgaacc cccaacctac tgattacaag tcagttgctc 2589721 taccaattga gctacaccgg catatatgta aaaccgatat gtataatgaa aaatggtgga 2589781 ggatgacggg ctcgaaccgc cgaccctctg cttgtaaggc agatgctctc ccagctgagc 2589841 taatcctcca tacttgcact aacgtgcaat tgcttggcgg cgtcctactc tcacaggggg 2589901 aaacccccga ctaccatcgg cgctgaagag cttaacttcc gtgttcggta tgggaacggg 2589961 tgtgacctct tcgctatcgc caccaaacaa attgagagtg ttctctcaaa actagataac 2590021 aggtgtgaca tcattcaaaa atatggttaa gtcctcgatc gattagtatc tgtcagctcc 2590081 atgtgttgcc acacttccac ctcagaccta tcaacctgat catctttcag ggatcttact 2590141 tccttgcgga atgggaaatc tcatcttgag gggggcttca tgcttagatg ctttcagcac 2590201 ttatcccgtc cgcacatagc tacccagcga tgcccttggc agaacaactg gtacaccagc 2590261 ggtgcgtcca tcccggtcct ctcgtactaa ggacagctcc tctcaaattt cctgcgcccg 2590321 cgacggatag ggaccgaact gtctcacgac gttctgaacc cagctcgcgt accgctttaa 2590381 tgggcgaaca gcccaaccct tgggaccgac tacagcccca ggatgcgatg agccgacatc 2590441 gaggtgccaa acctccccgt cgatgtggac tcttggggga gataagcctg ttatccccgg 2590501 ggtagctttt atccgttgag cgatggccct tccatgcgga accaccggat cactaagccc 2590561 gactttcgtc cctgctcgac ttgtaggtct cgcagtcaag ctcccttgtg cctttacact 2590621 ctgcgaatga tttccaacca ttctgaggga acctttgggc gcctccgtta ccttttagga 2590681 ggcgaccgcc ccagtcaaac tgcccacctg acactgtctc cccgcccgat aagggcggcg 2590741 ggttagaagg tcaatacagc cagggtagta tcccaccgat gcctccaccg aagctggcgc 2590801 tccggtttcc aaggctccta cctatcctgt acaagctgta ccaacattca atatcaggct 2590861 gcagtaaagc tccacggggt ctttccgtcc tgtcgcgggt aacctgcatc ttcacaggta 2590921 ctataatttc accgagtctc tcgttgagac agtgcccaga tcgttgcgcc tttcgtgcgg 2590981 gtcggaactt acccgacaag gaatttcgct accttaggac cgttatagtt acggccgccg 2591041 tttactgggg cttcaattcg caccttcgct tacgctaagc gctcctctta accttccagc 2591101 accgggcagg cgtcagcccc tatacttcgc cttacggctt cgcagagacc tgtgtttttg 2591161 ctaaacagtc gcctgggcct attcactgcg gctctctcgg gcttgcaccc taacagagca 2591221 ccccttctcc cgaagttacg gggtcatttt gccgagttcc ttaacgagag ttctctcgat 2591281 caccttagga ttctctcctc gcctacctgt gtcggtttgc ggtacgggca cctctcacct 2591341 cgctagaggc ttttcttggc agtgtggaat caggaacttc gctactatat ttcgctcgcc 2591401 atcacagctc agccttatgg gaaacggatt tgcctatttc ccagcctaac tgcttggacg 2591461 cggatatcca ataccgcgct taccctatcc tcctgcgtcc ccccattgct caaatggtga 2591521 ggaggtggta caggaatatc aacctgttgt ccatcgccta cgcctttcgg cctcggctta 2591581 ggtcccgact aaccctgagc ggacgagcct tcctcaggaa accttaggca ttcggtggag 2591641 gggattctca cccctctttc gctactcata ccggcattct cacttctaag cgctccacca 2591701 gtccttccgg tctggcttca cagcccttag aacgctctcc taccactgtt cgaagaacag 2591761 tccgcagctt cggtgatacg tttagccccg gtacattttc ggcgcagagt cactcgacca 2591821 gtgagctatt acgcactctt taaatggtgg ctgcttctaa gccaacatcc tggttgtcta 2591881 agcaactcca catccttttc cacttaacgt atactttggg accttagctg gcggtctggg 2591941 ctgtttccct ttcgactacg gatcttatca ctcgcagtct gactcccaag gataagtcat 2592001 tggcattcgg agtttgactg aattcggtaa cccggtaggg gcccctagtc caatcagtgc 2592061 tctacctcca agactcttac cttgaggcta gccctaaagc tatttcggag agaaccagct 2592121 atctccaggt tcgattggca tttcacccct acccacacct catccccgca cttttcaacg 2592181 tgcgtgggtt cgggcctcca ttcagtgtta cctgaacttc accctggaca tgggtagatc 2592241 acctggtttc gggtctacga ccacgtactc atgcgcccta ttcagactcg ctttcgctgc 2592301 ggctccgcat cttctgctta accttgcacg ggatcgtaac tcgccggttc attctacaaa 2592361 aggcacgcca tcacccgtta acgggctctg actacttgta ggcacacggt ttcaggatct 2592421 ctttcactcc ccttccgggg tgcttttcac ctttccctca cggtactggt tcactatcgg 2592481 tcactaggga gtatttagcc ttgggagatg gtcctcccgg attccgacgg aatttcacgt 2592541 gttccgccgt actcaggatc cactcaggag agaacgaagt tttgactaca gggctgttac 2592601 ctcctatggc gggcctttcc agacctcttc atctacctcg ttcttttgta actccgtaca 2592661 gagtgtccta caaccccaag aggcaagcct cttggtttgg gctgatcccg tttcgctcgc 2592721 cgctactcag ggaatcgcat ttgctttctc ttcctccggg tacttagatg tttcagttcc 2592781 ccgggtctgc cttctcatat cctatgaatt cagatatgga taccactcca ttacgagtgg 2592841 tgggtttccc cattcggaaa tctccggatc aaagcttgct tacagctccc cgaagcatat 2592901 cggtgttcgt cccgtccttc atcggctcct agtgccaagg catccaccgt gcgccctttc 2592961 taacttaacc gttaaaaaga atcactatgt gatatcttgt gttactaatt gaatgtgatg 2593021 tctactgtta tctagttttc aaagaacacg tttcgaagga atgatccttc aaaactaaac 2593081 aagacaggga acgttctgtt tataagacct tgggtcttat attccgtata atatccttag 2593141 aaaggaggtg atccagccgc accttccgat acggctacct tgttacgact tcaccccaat 2593201 catctgtccc accttcggcg gctggctcct aaaaggttac ctcaccgact tcgggtgtta 2593261 caaactctcg tggtgtgacg ggcggtgtgt acaaggcccg ggaacgtatt caccgcggca 2593321 tgctgatccg cgattactag cgattccagc ttcacgcagt cgagttgcag actgcgatcc 2593381 gaactgagaa cagatttgtg ggattggctt aacctcgcgg tttcgctgcc ctttgttctg 2593441 tccattgtag cacgtgtgta gcccaggtca taaggggcat gatgatttga cgtcatcccc 2593501 accttcctcc ggtttgtcac cggcagtcac cttagagtgc ccaactgaat gctggcaact 2593561 aagatcaagg gttgcgctcg ttgcgggact taacccaaca tctcacgaca cgagctgacg 2593621 acaaccatgc accacctgtc actctgcccc cgaaggggac gtcctatctc taggattgtc 2593681 agaggatgtc aagacctggt aaggttcttc gcgttgcttc gaattaaacc acatgctcca 2593741 ccgcttgtgc gggcccccgt caattccttt gagtttcagt cttgcgaccg tactccccag 2593801 gcggagtgct taatgcgtta gctgcagcac taaggggcgg aaacccccta acacttagca 2593861 ctcatcgttt acggcgtgga ctaccagggt atctaatcct gttcgctccc cacgctttcg 2593921 ctcctcagcg tcagttacag accagagagt cgccttcgcc actggtgttc ctccacatct 2593981 ctacgcattt caccgctaca cgtggaattc cactctcctc ttctgcactc aagttcccca 2594041 gtttccaatg accctccccg gttgagccgg gggctttcac atcagactta agaaaccgcc 2594101 tgcgagccct ttacgcccaa taattccgga aaacgcttgc cacctacgta ttaccgcggc 2594161 tgctggcacg tagttagccg tggctttctg gttaggtacc gtcaaggtac cgccctgttc 2594221 gaacggtact tgttcttccc taacaacaga gctttacgat ccgaaaacct tcatcactca 2594281 cgcggcgttg ctccgtcaga ctttcgtcca ttgcggaaga ttccctactg ctgcctcccg 2594341 taggagtctg ggccgtgtct cagtcccagt gtggccgatc accctctcag gtcggctacg 2594401 catcgttgcc ttggtgagcc gttacctcac caactagcta atgcgccgcg ggtccatctg 2594461 taagtggtag ccgaagccac cttttatgtt tgaaccatgc ggttcaaaca accatccggt 2594521 attagccccg gtttcccgga gttatcccag tcttacaggc aggttaccca cgtgttactc 2594581 acccgtccgc cgctaacatc agggagcaag ctcccacctg tccgctcgac ttgcatgtat 2594641 taggcacgcc gccagcgttc gtcctgagcc aggatcaaac tctccgataa atggatcaca 2594701 ggttaagttc accgcatcct gcggcgacac ctgtgtgacc tgcgtcgtgc aggccctagt 2594761 ttgactgact acgcacatcg cagtgcgatt tttaaaaact gaattaacag gtacgttttg 2594821 tcttgtttag ttttcaaaga tcatttcgtt acttctcaat gaagcagctt tactaatata 2594881 acattcagct tcttttttgt caacaacttt tttcaagttg ttttgaagca tctagtttgt 2594941 gtccgctgtg catcagcgac gtttaataat ataacacctg tatttattta ttgcaatagt 2595001 tttttaaaaa aaatctataa aacaaataaa ctataatcct cgccatgatt tctaaagcgt 2595061 gtgtatcata taagtttctt aaaagaacat atacatcagt catgtgatct tgttgttttt 2595121 ttcgttttct tgtatagtag aaacgaacta aatactgatg accacaaggg gagcattaaa 2595181 gctgagagtg agcggtttcg ttctgaccct ttgaacctgt tagttaacgc tggcgtaggg 2595241 atgtggcaaa gtcaaatgaa ttgcagatcg taaagcagtg cgtggaactt ttctcatcct 2595301 tccgcgtgct gcttttttgt tgtccttttg gttgtctgtc aatggaagga gatagatatg 2595361 aatcaatcta agcaactggt tcgccttatt gaaattgcca ttatgacagc ggcagccgtt 2595421 attttagaca ttgtctcagg aatgtttctt agcatgcctc aaggaggctc ggtctccatc 2595481 atgatgattc cgatcttttt aatttcgttt cgctggggtg tcaaagcagg tcttactaca 2595541 ggtttgttga caggtctagt acaaatagca atcggaaact tgtttgctca acatcctgta 2595601 cagctattgt tagattacat tgtcgctttc gcagcaatcg gcataagcgg ctgtttcgct 2595661 tcttctgtcc gtaaagccgc tgtatcaaaa acaaaaggga aattgattgt ttcagtggtc 2595721 agcgcagttt ttatcggcag tttgctgcgc tatgccgcgc atgtcatttc aggagctgtg 2595781 tttttcggca gctttgctcc aaaaggaaca ccggtatgga tttattcttt aacttataat 2595841 gcgacttaca tggttccttc attcattatt tgtgcaattg tcctatgttt attatttatg 2595901 acagcacccc gtctgcttaa aagtgacaaa gcgtaaaagt aacaatcccc cagcgaattc 2595961 cgctggggga tttttcgtta tctgttaaga agtgttttta aagctgaaag atccggccag 2596021 ccaagaccta cttctttcag ccttactccg gcaatttcaa agttgtcctc cgctactctt 2596081 tcaggtgaat aggcctgata aaatataatc gagggattct gctcaataac ccaaacaaac 2596141 atacttgaaa aaccatgttg aagcaaaaac tccgctcctt ttgctaagag cgccctgcct 2596201 gcaccttgcc gctggcgctc ttccagaaga taaatagcgt ataactcgcc gtcatagcct 2596261 tcttgttcag agcgaatagg tccaaatgaa gcaaagccga atactgaacc cttttcgtcc 2596321 tgagcaacaa atactccctt taacgagcga cttttccatt tgtcttcaaa ttccttatag 2596381 ttcaggctgt ttaaataatc aatcgggata atttcgtggt atgttgtcct ccagctgtct 2596441 acatgcactt ttgcaatgtc ctttatatcc tctaacttcg cttcacgtac agttaccata 2596501 cggttctgcc ctttccttac tctgattttt ggatcgtttt ggcttctttg atttcatttg 2596561 ttaattcatt aatgctttgt tttacgtttc cttttcctga aaagttctca agcatttctt 2596621 ttacatcaat tcctgaggat gcttttaaac tttcttgcag acttgacatt aagttcgtcg 2596681 catagctggt tactttgttt gctccgcttg attcaccgct tcctcctgta tcgacaacgg 2596741 tgattttatc aatatttgaa agaggtgccg ctgcttgttt cgcgtattcc ggaagcattt 2596801 tgacaatcat atcgaaaatc gccgcctgcc cgtactgttc aaaggcggcc gcaattttct 2596861 cttttgcttc cgcttctgca agacctttca ggcggataac ctctgcttct gtctctcctt 2596921 tcgctttttc cgcttctgct tttgctagcc cgtcaattct tactttttcc gcctcagcct 2596981 ttgccattgc ttcaatactg tacttcttgg catcggcttc cgcgagctgt ttggctttct 2597041 cagctgctgc ggactgctca acagaataac ggtctgcatc ggcttttttc tttacctctg 2597101 agtcgtattg acgttcacgg cgaagaattt ctttttcttc tagttctatt tgtttttggc 2597161 gttcgataat tttaacctgc atttcctgct ctgtgacttg ctggcgcgct cgggcagtct 2597221 ctaaatcata tgcttggtcg gcattcgctt ttgccgtatc ttgttctctg cggaattcag 2597281 ccattttgag ctgattgatt ttttcagctt cagcgatttc cgtcgcccgt tcaagttctg 2597341 atttttttgc gtctttatcg gcttctgccc gcttaattcg ggtttcttta tcagcctctg 2597401 ctgttgcgat atcagcatcg cgttttactt gggcaattct cggtttccct aatgattcaa 2597461 gataaccgtt tttatcacga acatctttaa tggtaaacga gacgattaca agtcccattt 2597521 tcgcgagatc ctgtgaagcg acacgctgca cctcttgaga gaatttttct ctgtttttat 2597581 agatttcttc tactgtcatt gagccgagaa tggaacgaag gtggccttct aaaacctccc 2597641 gcgcttcctg ctcacggtcg tcttttgatt tccctaaaaa ttgttcggcc gctgtagcga 2597701 tttctcctat agaaccgccg attttaataa tcgcagttcc atcggccatt actggcactc 2597761 cttgttctgt atagacttca ggtgtcgaaa catcgagttt gcttgataat aggcttagcg 2597821 gctctgcctg ctggaagacg ggaaggacaa aggttcctcc gccgcggacg attttaatac 2597881 ggttgccgcc ttcatcgaca tgaacatttt tattacccag atagctccct gttacaatta 2597941 acgcttcatc aggccctgct gtacgatact tcgtaataaa cacagctatt agtgcaatta 2598001 ataaaaagaa tacaactccg atgatcatta taatcggcat tgtcatatca aattcctcct 2598061 tttatgttaa atgggttcat gcggagtaac cgaaagaact ccgttgttaa tatctacgac 2598121 taacaccgtt gtcccgtaac tgatctgctg attatcaaaa ctgaccgctg actttgaaat 2598181 ggtcccgcct atcccttcta tgaccacttc accaaacccg tcaaccggca cagctgtaat 2598241 cactttaccg agtcttcctc tgagatcatc ttctctatat gccaatgatt cttctgcaga 2598301 tgataatggc accagtacaa agatgtgaag caataccacc agcatgatcg aaaggatgca 2598361 agataaaagc gcaatcagca agcttgacag aggcaataca agttcaccta tatatccgcc 2598421 cgctgaaaaa catgtaaaaa atgagagcac taatgtcgga ttaagaaacg gaatgccttc 2598481 tgacagccct gaaaatacat ctccgaaaaa caggaataac agcgtaaggc tgcccgcaat 2598541 aataagcgta taaagataca ttgtttgtat aggtactcca aataactcca acttcctcat 2598601 cctttcttca tcaatgcatt gatgaacggc tgccgttacc atttatacga gacacctcgg 2598661 gaaaagtttc aaaattttaa gacaaataac ccatttgaag tgctttataa atgataattg 2598721 cttatatata tggtaatgtc attttaggag gagatatgat gagtatcttt aatgaagcca 2598781 gattagaaac gtggaacgaa ttgaaaggac tttctgacga aaagctgaat caaaagcctt 2598841 ctgctgaaga atggagcata cgggaagttc ttgaccattt gaaaaaaatc gatatgaccg 2598901 cacaaaaaat gttgaaggaa cgtgtaaagg acgctccgat taaagaaatt gaagaaaaac 2598961 cgcttgaagt agcacaggac agaaataata aacggaaagc cccgagtcat cttgagcctg 2599021 cgcatgattt tatttcaggc agccaaatga aacgtgagct tgatgtggta agagagcagc 2599081 tgactgctgc gattgcctct ctgaaagaag aagattttga aagagtgctt ccgcatcctg 2599141 tgtttcaaga gctgactgtc agacagtgga tcgattttat cggccatcat gaaaaacggc 2599201 acctcagcca aatgaaagaa attaaagaaa agatagaaag ggcctgattt aatcagaccc 2599261 tttctgcttt tcgtttgact tttcgctgat aggaatgaac ttctatttca tcacctgtgt 2599321 aaacagcacc aggtctctcc acaatacaga caatccctct aatgcccagt gcgtggcgga 2599381 cgaaagccga cgccagcttc ggttggtccg gataataaga ctgaatgact tctcccggct 2599441 ggatacacgg atcattttcg ccctcacaca gcagagccgc tccgctcgga aaaataatcc 2599501 ggcttccttc ttttaatgaa gtaagatctg gcataccgct gactgccaca ttcgccccga 2599561 gccattccgg caaaattctc ggcactccca tttttaaagc gatttcgttg cattcctcta 2599621 ttgaaacaat tgaaatttgt ctgcggttga aaatttcagt ccctcttgaa aacattggtt 2599681 ctctggctcc cgcttttttg gtcaggccaa aatgcaagtc gccggggatg ccgccataat 2599741 caaaatcaag cttgtccatt tgctttgtta cgaagctttt tgtatctgcg atatataagc 2599801 cttccgcttt tgcagtcata cgcttccaca tcagctggca ccttccttct tatctaaaat 2599861 ttccacctat gcttcattat cccaaaaaat cccgctctgt aaaggagcgg gattttgatt 2599921 ataccgtttt aggcgtaagg ttaaagcagc gtttgtagat ccagttgtat gctttttcat 2599981 ttaaatctct agggtttccg aaggtttgcg gatctttcat tgcttcttta gacaagcgtt 2600041 cgatcatatc aggtgatact ccctgctctt ctaaagtcgg cacttctaaa tcttcgacca 2600101 gatcatacat ccaattgaca gatgctttcg cagcttcttc tgttgtcatc ttgcttgtat 2600161 caataccgaa cgctttcgca atacgcgcaa acttctcagg atagcccttc cagttgtatt 2600221 ccatgacagg gcccatcatc gccgctacac attggccgtg agcgactggg ataataccgc 2600281 caagcgtttg gctcatcgca tgagcagcgc ccgctgattc acttccgtaa gaaagaccgg 2600341 caagcatcgc agcctgcgcc attccgtacc ttgcttccag atcctctcca tcagcaaatg 2600401 ccctcttgat gtaatgagcg gcatactcaa tcgccattaa ggcaaccgca tccgtgattg 2600461 gctgtgcaaa tttcattgta tagcactcaa tggcatgggc gagcgcatca attcccgtca 2600521 tagctgttac atgcggaggc attgaaacat gaagctcagg atcaatgatt gtcaagtgcg 2600581 ctgcaatcag cggaccgccc gtgttgaatt tgaattctct ttcttcatct gtgataaccg 2600641 cccattgggt tacttctgat ccggttccag ctgtagtggg aattgtcgtc agcggaggaa 2600701 tgcggttttc cagcggtttt ttcccatctg ccgcttcata atcaagcacg cttccttcgt 2600761 gagtcgcttc tactccgatt gcttttgctg tatccatgga gcttccgcct ccgactgcca 2600821 ccaaaccatt acagttctct tttttgtaaa gctcagatcc ttcattcacc agacggacag 2600881 gcgggtttgg ctcaacttta ttaaagagta ccacttcaat gcctgcttct ttaagtgatt 2600941 cgattacggg atcagcaaca ccggctttat aaatcccagg gtctgtgaca aggagcgctt 2601001 ttgaaacgcc cagtgcagct acttcctcac ccgtatgctt gatggctccg attccatgct 2601061 taatcacagt cggaatttca aatgtgtgga atttctgcat gctttctacc ttcatattta 2601121 atgtcatcat caatctcccc ctcttatgaa ttaaaccagt taaccgctgc cggttttgta 2601181 ttgcggtata catgtttgac ttctgtgtat tcttcaaggc ctatttttcc aagctcgcgt 2601241 ccgaacccgg attgcttata tccgccccat ggcgcttgtg caaagtacgg atgaaaatcg 2601301 ttgatccaaa cggttcccat tctcaagcgg gctgctaccc gttcgcactt ttcaatgtct 2601361 tttgaccata ccgctccagc caagccatag atggtatcat tcgcaagctc gattacctct 2601421 tcttcagagc tgaaggtttc gactgtcaat acaggaccga aaacctcttc ctgaacgatt 2601481 ctcatgtcag aattacagtt tgagaaaata gtaggttcat agaaaaagcc gttttgaagc 2601541 tcaggatctt ccgggcgttt gcctcctgtc tccagcttcg cgccttcctc tattccgatc 2601601 tctacatatt tttctacctt tgccctgtgc tccgccgaaa taagcggacc gctttctgtc 2601661 tcagcatgaa aaccgtttcc gagttttatg cgttttgccc gtttgaccag ctccgccaaa 2601721 aattgatcat gaatggcatc ctcaacaagc aagcgggaac ctgcagagca tacttggccg 2601781 gcgtggaaaa atacagcgtt taaggcctga tcaaccgcaa cttctaaatc cgcgtccttg 2601841 aaaacaatat ttgggttttt cccgccaagt tcaagggcga tttttttgac gtttccgctt 2601901 gccgcccgca tgattttttt gcctgtttca attccgcccg taaatgaaat caaatcgacg 2601961 tctttgttta cggcaagctc gtcgcccact gtggctcccg gtccaagaac aagatttgcg 2602021 acaccttttg gaacaccggc ttcttccatc agcttaaaga ctttgattgt cgtcagcggc 2602081 gtaatctcac tcggcttcat gacgattgtg tttcctgcgg ccagtgcagg ggcgattttc 2602141 cagctcgctt gaaggagcgg ataattccat ggagtgatct ggccgcaaac cccgattggc 2602201 tccctaataa ttttgctttc tgaatcagga atcggagatg aaatgatctc tccgccatct 2602261 ttgtctgcca agccggcgta atattgaaaa acattggcga tatcgtccat atcggccttg 2602321 ctttcttcga gtgtttttcc tgtatcaaga gattcaagct cagccagctc ctcaagatcg 2602381 cgtctgatta attccgcaat tttcagaaca atttttccgc gttcaagccc ggatagcgat 2602441 gaccattctc ctttgtcaaa tgctctacgt gcggctgcga ttgctttgat ggcgtcctct 2602501 cgccctccct cgcttacagt tgcaatttct tcttgattaa atgggttgat aatactgcgg 2602561 atctgttctt tttcggcact gatccattct ccgtcaatga ataatgtttg actcatataa 2602621 gcctccttga cgtaaataaa gtttgttaaa taaaaattta atgtttttaa caaccttaat 2602681 ctaacatatg gtttttaaac tgtcaaagtc ccattttgat ttttcttttt gacttttcct 2602741 catgtttcgt taagataaag aacataaaga aataacttaa cgaatttaat tttctaaagg 2602801 aaaagagggt cagtatggat gaaaatccag aatttgcagc tatagaacag gctcgggatc 2602861 ttgttattga ctccattgct gaaacgatgg atctttacgg aattacccgc agtgtcggga 2602921 ttttatatgg gacgatgtat atgagggatg agatgacgct tgacgaaatg cgtgaggagt 2602981 tgcaaatgag caaaccaagc atgagcactg gcgtcaaaaa gcttcaagac ttaaatgtag 2603041 tgaaaaaaac atttcaccgg ggcatccgca agcatacatt tgtggctgag aaggatttct 2603101 ttaaattttt cacaaatttc tttccaccta aatgggagcg ggaggttcaa gtgaatgtaa 2603161 cagcgatcga ggaagctcaa gctgatttac aaaaggtttt atgcaaggaa gatctcgatg 2603221 aggatatcaa aaatgaagca ctgcagttat atgatcagct ggaaagctct aaagcttact 2603281 atgactggct gaaacggctt gctgaatcgg tgcagaccgg agaaattttt aaatttatac 2603341 cggtcgaaac aaagtaaagc agaaaacgcc tgggaaacta ggcgtttttt tgatgtaact 2603401 actacaaatt tgaaaaatac gggaaaaaca ccccatttac ttccaaaata tttgatggta 2603461 attttatgta ggtaaaattt gtatttggcc tttcagagga ggtgaaaagc gggcaggcct 2603521 gtttaattta tcatttttta gggggaattt tgttatgaaa cgcaaattat tatcttcttt 2603581 ggcaattagt gcattaagtc tcgggttact cgtttctgca cctacagctt ctttcgcggc 2603641 tgaatctaca tcaactaaag ctcatactga atccactatg agaacacagt ctacagcttc 2603701 attgttcgca acaatcactg gcgccagcaa aacggaatgg tctttctcag atatcgaatt 2603761 gacttaccgt ccaaacacgc ttctcagcct tggcgttatg gagtttacat tgccaagcgg 2603821 atttactgca aacacgaaag acacattgaa cggaaatgcc ttgcgtacaa cacagatcct 2603881 caataacggg aaaacagtaa gagttccttt ggcacttgat ttgttaggag ctggcgaatt 2603941 caaattaaaa ctgaataaca aaacacttcc tgccgctggt acatatactt tccgtgcgga 2604001 gaataaatca ttaagcatcg gaaataaatt ttacgcagaa gccagcattg acgtggctaa 2604061 gcgcagcact cctccgactc agccttgcgg ttgcaactaa tgtaaaagac cggttaacgc 2604121 cggtcttttt tgcgttttac cctccccttt ttctctaatc cccgttatct tttttctggt 2604181 ttaaaattta aattgacaaa cactagaaac aggagtaaat tcttgagtgt tcaatttcat 2604241 acagtctctt ttaccgctta atcaaacacg aacgggggaa ccaacgattg gctgttttat 2604301 taacagcctt ggggtgaatc ttactaagta agagggggta ctctgaatcc ctaatccgac 2604361 agctaacctc gtaggcgtat acagagagga ggtctattat cggccattct ttgcaatggt 2604421 cttttttgtt tcaaaaacgt taattcacta agggagatat gaacattggg aagaattaaa 2604481 aataagcaat ttgccgtgat cgggctgggc cggtttggcg gcagcatttg taaagaactt 2604541 catagaatgg ggcatgaggt ccttgcggtt gatatcaacg aagaaaaggt caatgcatat 2604601 gcttcttacg ccactcatgc ggtaattgcc aacgccaccg aagaaaacga attgctttca 2604661 ttaggaatac gcaattttga atatgtgatt gttgccatcg gagcaaatat tcaagcgagt 2604721 acgctgacca ccctattatt aaaggagctt gatattccaa atatttgggt gaaggctcaa 2604781 aactattatc atcacaaggt gcttgaaaaa ataggcgctg accgcattat tcatcctgaa 2604841 aaagatatgg gggttaaaat cgcacaaagc ctttcagacg aaaatgtttt gaattacatt 2604901 gatctatctg atgaatacag tattgtcgag ctgctggcta cgcgcaagct tgattcaaaa 2604961 tcgattattg acctgaatgt aagagcaaag tacggctgca cgatcctggc cattaaacat 2605021 catggagata tctgtctttc ccccgcgcct gaagacatca ttcgcgagca agattgcctg 2605081 gtgatcatgg gccacaaaaa ggatattaaa cgttttgaaa acgaagggat gtagacaaag 2605141 gtgacacttc aaaaggataa agtgatcaaa tgggttcggt ttacaccgcc tcaagtgctt 2605201 gccattggtt ttttccttac cattatcatc ggggctgtcc tattaatgct tccgatttcc 2605261 actacgaagc cattgtcatg gatagatgcc ctttttactg cggcttccgc tacaactgtt 2605321 acagggcttg ctgttgtcga taccggcact caatttacgg tattcgggca aacagtaatt 2605381 atggggctga ttcagattgg cgggcttgga tttatgacat ttgcggtctt gatcgtcatg 2605441 atattaggaa aaaaaatcgg cttaaaagaa cgaatgctcg tccaggaagc cttaaaccag 2605501 ccgacaatcg gcggtgtcat tggccttgtc aaagtcctgt ttctgttttc gatcagtatt 2605561 gaattgatag cagcactcat tttatccatc cggcttgtac ctcaatacgg ctggtcatcc 2605621 ggcttgtttg caagtttgtt tcacgcaata tctgctttta acaatgccgg gttttcgttg 2605681 tggcctgata atttgatgag ctacgttggc gatcctacag tgaacctcgt gattactttc 2605741 ttatttatta caggagggat cggatttacg gttctgtttg atgtgatgaa aaatcggcgt 2605801 tttaaaactt tttctttaca tacaaagctc atgcttacag gaacgctgat gttgaatgcg 2605861 atcgctatgc ttacggtctt tattttagaa tacagcaacc ccggcacgct cggccacctg 2605921 catatagtgg ataaactgtg ggcctcctat tttcaggcag tgacgccgag aaccgcaggg 2605981 ttcaattctc tagattttgg aagcatgaga gaaggaacaa ttgtatttac tttattattg 2606041 atgtttatcg gagcaggaag cgcatcaacg gcgagcggca ttaagctgac tacgttcatc 2606101 gtgattttaa catctgttat tgcttacttg agaggtaaaa aagaaacggt tattttccgc 2606161 cgttccatca aatatccgat tatcattaaa gctttagctg tgagcgtcac cagtttgttc 2606221 atcgtgtttt tagggatttt cgccctgacg atcacagaac aagcgccatt tcttcaaatt 2606281 gtgtttgaaa ccttttccgc attcggaact gtcggcctta cgatggggct tactcctgaa 2606341 ctgacaacag ctggcaagtg tatcatcatt gtcatcatgt ttatcggaag aattggtcct 2606401 ttaacgttcg tgttttcatt cgcaaaaaca gagcaatcaa atatccgtta tcctgatggc 2606461 gaagtgttta cagggtgata tcaaaaaaat ccggcgtgca gtcgccggat tttttatgat 2606521 tcgatatgag attgattttg tcttttttcc tgttccgcga tgatttcgtt atcctccgcg 2606581 ttatcacggg tcactttttg cgtaagaatc gcaccaactg ctacaagtat cataacagcg 2606641 atgtaataac ctttttcatt gagttccaga ttatcagcat tatagagtcc gatactaaac 2606701 aaaaatactc ccgcaaaaaa agtaaaataa gctagtactg taaaggcaac cgtgtttctg 2606761 cgtctatatt tctgcacctt tgttccctcc cgaaagcata gttaaaaagt gataacttcc 2606821 gtggaatatt atacctcaaa ttccccggaa tggaacaaag aattaaaaat accagtaaaa 2606881 agggcttagg ttgcctcctt tatttcaaca gctgaatcat caatccagcc gataagttta 2606941 tcattgattt ggaattggta ccatacagac tggcctttct gttttttaga cacaaccttt 2607001 atgtctttgc cgacgtaaga ttgggcagag gtaagcctta tggaccgatc atcagtagaa 2607061 ggcttggacc atacgtcttg aacggcactg tctttaatag aggcgtttaa atccacagat 2607121 ttgagggatg gatttacctc atcgtactca tctaaatcgt atttttccac aatagcgctg 2607181 attttgtcag cgtagtcagg gtctgtagca tatcctgatg tttgcagggc ggttgccgct 2607241 tccttataat tccctgcctc aagcaccggt ttatacttct ttttattcca cgatgtgcca 2607301 cggacgaaca attgggcgtg atcatccata gattcaaaaa acgtgctgta ttttcgaaac 2607361 ttcgcgcgaa tggtttttct tttccctttt tcaacttcgt ccgtttccat cgtgacatga 2607421 tggcctttat aattcccttt tacgccaaaa aggttgttgg ccttagcagc cagttcactg 2607481 ttcccccagt ccgattcgag aatggcctga gcaattgtga tgctggggag aacatggtat 2607541 ttttcataca aaatttgggc atgtccggac agactgtcta taaatacttg ctgttcatcg 2607601 atttcttcag tttctttgga tatttcaatc ggttttgata aagttgtcgc taaaacaaac 2607661 agagctagcg gaatcgatac aaggaaaaat agtgaaatca agagtttacg ttttttaagt 2607721 tttttacggg ccatgaaaac cttccttcga attaaaagat tacgaatgta aaagaatcta 2607781 ccttttagaa ttttacttgc acttctaata tttttcaatt ctttagggat aaagttggga 2607841 aaagattgca aaataaaaac cttttcgctc aatgaaaagg tttttaccat gtttctattt 2607901 ttgtaaattt ctgagtgcat tccgatattc cgtatcattt attactttat atgatttgac 2607961 agttgccttc gacaaacctt gtgctgagac ggccggtttt tccggagctg ttttcgcttt 2608021 atcatgtggt ttatgtgcca gcttgtgccc cattccagtg gcattcatac aaaatgacag 2608081 gcagacgagc agcacgctaa ggataaaaga aatgaagaag agatcatgat aagcagtcat 2608141 catagaatcc tgtaccgaac cgctttgtct ggcagcatct tttttcgtga aaaagccgat 2608201 gagaatggga actcccatat agacaaacaa tcttaaaaac tgaacagctg tcattctctt 2608261 gaccaaatca ggcagcgggc ctcccatggc agctcccatc agccctgcgg cgactgtcag 2608321 gcctgttccc gctgcaagca tgataaacag tgccgcgaac atataaagag atgatcgatc 2608381 ctgtatatgc agccattgaa aattcacaaa aacgagaatg agtccgccga taataccgag 2608441 catccctggt ccgactttat cgtataacag agcgctcaaa atggccgcga tcgccactcc 2608501 gattaaaaga gtcaagctta aaagaatgag atgctcctga gaaatatcat acatttgacg 2608561 gagcaagcct tgaaaagcag aaaggctgac agctaccgtt atcgtccctg cagctatgat 2608621 caataagccg agcaccggtt ttggcagcag catcagttta atagatatga aggggttttt 2608681 cactttatat tccacaatca atagaccaat gagcaaacat aacgtcaccc cgaaaccaat 2608741 ccatacataa cccgatgaca gcccccattt ttgcagaaaa atgaatgaaa ccgctgaggc 2608801 tgcggcaagg aagacagata aaagaattcc cgcacgatca agcggctgtt cttgatccgc 2608861 cgctccgtga tgctcatcat gaagaaagaa atagctcacc gcgacaccga tcagggacaa 2608921 ggtgccaaag atgaaaaaca gccatctcca atgcccgcag cttgttgcaa tggttcccag 2608981 gattgtaccg atgataacag aaccatagaa tcccccgatc agcacaagca gtgcatagtt 2609041 cctgcgttca atcgggaatg acagtacaag cattggaatc ataatcatca gcatgacgcc 2609101 tgttgccgcc ccttgtaaaa agcgccctgc cgccatcaat gcaatatcgc ctgaacatgc 2609161 gatgagcagt gagcctagta taaagacagg taatgaagcc agatagacgg gacgagcacc 2609221 gaattttttc ctcagcagcg gtcctgccgg aactaacaag gcaaaggcca tattgccgat 2609281 caatatcgga tttactgatg taaagacact tgttccaacc gttttctgaa caaggccttg 2609341 aactgacgac aatgccgtgt tagacatcaa tcccggcccg accgctaaga cggcgagcaa 2609401 agaaatcacc caatagtgtt ttgtcttcat gttgtcatcc cttcctatat gaatacatgc 2609461 gaaacacatc attttttgaa aacaaaagaa gctaatagat tttgcatacc attagctttc 2609521 attctaatat tctccctttc aggggaaatg atattatttt attataatta tgtgaatgaa 2609581 tgagcatata atcaaatatt atttcaaatc gattgtgttt tgtcaatgga gtaaatttca 2609641 agcacaacat agaaagcttg aaagcttttc cccgatattg tgtctagaac tgcacttatg 2609701 aatccctgct cgttccctca agcgaattaa agcaggccgt tttaatcctt tcaatccact 2609761 attccaacta ataaactcaa ataagttggt gataagacaa cattttaccc ccacattttt 2609821 ttgtgttcac tgggcgtttg ccgcctctaa attgtatatg ggtaaatacc atgaattaac 2609881 ctatgaaata ccaatgtaag ggaggcaaaa acgaatggaa ctgtatgagt gtatccaaga 2609941 catttttggc ggcttgaaaa atccatcggt taaagattta gcaacgtctt taaaacaaat 2610001 tccaaacgca gcaaaattga gtcaaccgta tattaaggaa ccagaccagt acgcttacgg 2610061 ccgaaatgcc atctatcgaa ataatgaatt ggaaattatc gtgattaaca ttccgccaaa 2610121 caaggagaca acagtacacg atcatggtca atccattggt tgtgcaatgg tgttagaagg 2610181 aaagcttctt aattctattt atcgttcaac cggcgaacac gcagaactct ccaattcata 2610241 ctttgtccac gaaggagaat gccttatttc aaccaaaggt ttaattcaca aaatgtccaa 2610301 tccaacatct gaacgaatgg tgtctcttca tgtctactcc cctcctttgg aagacatgac 2610361 ggtctttgag gaacaaaagg aggtattgga aaattcatga ttgacagata aactgctcac 2610421 tttgacttca ctcaactgga ggattcagag aatgaaacct tttcctcaaa acaaaaaaac 2610481 ccttatcgaa taagggttta aaggtatgga gccaaggggg ctcgaacccc tgacctctac 2610541 gctgccagcg tagcgctctc ccagctgagc tatggccccg tatgtaacgt catgtttatt 2610601 atagatgatt ttattttgaa aaacaagctg tttcctcttg aattgacaga aaaaataagg 2610661 ctcggaaaag agccttattt ttcgacttac atcatgatca aaagtaaaat cacaccgaga 2610721 ataattcgat agattgcaaa tgggacaagt ttgattttgt taatcagcct taagaagaaa 2610781 cggacgacaa acagtgcgac cacaaaggca cagataaagc cgacgatgaa aaacggcatc 2610841 agatccgaac ttaagctgtc ccaatgcttc acgaggctta gaaagctggc tcccatcatg 2610901 atcggcatcg ccataataaa cgtaaagtcg gctgcagctc ggtggtttaa tccgagaata 2610961 acaccgccgg aaatggttga acccgaacgc gagaaaccag gccaaaggga aagacattgg 2611021 aataagccga cggctatcgc ctgtttatag gaaatgcggt cgagtgtgtc tgtcgctgtt 2611081 ttccgtttat tgacccagtc agcaaaaagc atgaggattg ccccggcaat taaaccgatg 2611141 gccacagttt taacggaaaa taaatattca tcaatgtaat cttcaaacaa aaagccgaga 2611201 acagctgcag gcacgagtcc gacggcaatt tgggcaatgc ttaatttatg tccctgctcc 2611261 tggtcgcttg taatattttt tttcaagccc agtaaattta aaattcggtc tttaaacacg 2611321 atagctactg ctaaaatgga gcctagctga ataaccacct tgaatgagtt agcagcttct 2611381 tctgacatca gattacttga ttttagccag atgtcgtcta ctatgatcat atgtcctgtc 2611441 gaagaaaccg gcgcgtactc tgttaatcct tctacgattc ctaaaatggc ggctacaaac 2611501 aattcccata gagtcatgat tttgattctc cccattagac atttattttt ttacataacg 2611561 ggagcttccc ataaatggaa agcccgtctt atataactat aaacgaaaat cacactttat 2611621 gccccggcgt attttcattt ttttcttcat cgtataaatg tgactgcatt ttaaaccagt 2611681 caaataaatg tgtcgtaatg actttggcaa ccgcatagcc gggaatcgca agaatgattc 2611741 caacaacgcc aaacagcttg ccggctgtta acagcagaaa aataatcgta atcggatgga 2611801 tgtgaaggtt ttttcccata atttgcggag agatcagctt cccttcaatc agctgaacaa 2611861 tcgtccaaac gatcaccagc ttaagcagca tgagcggcga tgtcactatg gcaatgataa 2611921 tcgcaggcgt aatggcaatc gttggcccta aatatggaac gatgcttgtg caagccgcaa 2611981 tgactgcaag caatgaagca taatccagcc cgataatcaa ataaccgata aacagcaaaa 2612041 acccgataca gaagctgaca atgatctggc ctctgatata agagcttaac cgatgattca 2612101 tttcgcttaa gactgtatat gtctgttctt tcaatcgagt cggcacaaac ttcagtatgt 2612161 agaccggtaa ttttcttccg tcttttagca aataaaatag aataaacgga accgtgacga 2612221 tcgaaatgat aatctcagtc agtgcgccga taaaattccc aacaccggta aaggtgctgt 2612281 tcacgatcgt cgctgcctga tccgaaacct ttgtagcaag atcagatata ttaatgttca 2612341 tcgtttgctg ggcctgattg acgaagttgc tgccaatcag ctgtttcgtc tgattttcta 2612401 cgacgtccac atatctcggg atattgtcaa tcaaactcat aatttgttct tttaagaagg 2612461 gaatgatcga cacgatcgtg atcgtgatca gcccgataac caataggtat agcagcaata 2612521 tagaatagat tcttcttatt cttcttctct ccagaaaatc gacgactggg tttaacagat 2612581 aaaaaacaat gcctgtcaaa ataatcggaa gtgatatcgt tttgagcaga acaataatcg 2612641 gggtgaaaat aaatgatgtt tttgtaaata ctagaatatt taaaccaatc agcagcagca 2612701 caagcaaaaa taaaacaaac ttattatcca agaagaatcg cttgaatctg ccgctccatg 2612761 tttgcaacgt ctccactatc gttcctccgt catacatagt ttaattaaat tgtacactat 2612821 cgtccctata atgaaaaata aaaaccgtta attgctggaa aagctttctc ggttttaaca 2612881 ttctatttat atctatcatg tgattttgtt ctttttaagc tataatttag ctatatcatg 2612941 caaaaggagc gatacgagtg atacgttttg caataatagg aaccaactgg attacagacc 2613001 gctttcttga gtcagcagcg gatatcgaag attttcagct gactgctgtt tattcaagat 2613061 cggctgaacg cgctggcgag tttgctgcta aacacaacgc tgcgcatgcc ttctcagacc 2613121 ttcaggaaat ggcggcgagc gattgctttg atgccgtata catagcgagc ccgaacgctc 2613181 ttcacaagga acaagccgtt ctctttatga accatggcaa gcatgtgctt tgtgagaagc 2613241 cgtttgcttc gaatacaaaa gaaacagaag agatgatctc agcggctaag gcaaacggcg 2613301 ttgttctcat ggaagcaatg aagaccactt tcctgccgaa tttcaaagaa ctgaaaaaac 2613361 acctgcataa aatcggcact gtccgcagat ttaccgcaag ctactgccag tattcctcac 2613421 gatatgacgc gttcagaagc ggaactgttt tgaatgcgtt tcagcctgag ctttccaatg 2613481 ggtcattaat ggatattggc gtctattgta tttatccggc tgttgtgttg tttggcgcgc 2613541 cgaaggatgt aaaagcaaac ggatatgctt tatcctccgg agtggacgga gaaggaactg 2613601 tcattctgtc ttacgacggg ttcgaagctg ttctgatgca ttccaaaatc tctacttcct 2613661 atgccccggc tgaaatccag ggtgaagacg ggacgattgt aatcgatacg attcaccggc 2613721 ctgaacgtgt tgaaatccgc taccgggacg gccgccttga aaacatcgcg atccctgatc 2613781 ctaaaccggc gatgttctat gaagcagaag aatttgtcac gcttataaaa gagaataagc 2613841 tggaatctga agaaaataca tttgaacggt ctttgaccac cgcaaaaatt atggaagaag 2613901 caagaaagca aatggggatt gtataccctg ctgatcaagc ttaaaaaaat ccgcccgcgt 2613961 gcaaatgccg cggcggattt tttattagac aatcggagaa gatgccttcc tttttaaaag 2614021 cacctgttgc tcatattctt tgatgtcata aagccatgcc tcttttaccg gaacgcccat 2614081 ttgctcacag taggaatccc agatggctcc gaaaggatat gttttgaatt cctccatcag 2614141 ggccagcctt tctgtatagc ggccctcttc ctgcaattgt tttaaatatc cgttcgggag 2614201 aagcagggca tacaataaag ctttgatcat atttctcgtt ccgatggtcc aggcggctac 2614261 acggttaatg ctggcatcga aaaaatccag accgatggct accttctcaa gagcatgatt 2614321 tcgtacaatt tcaagagcga tttctctcaa ttcatcatcc aaaaccacta catggtcgct 2614381 atcccaacga acaggccgcg atacgtgcaa ggcaagcttg tctgtgtaaa gcagcatgga 2614441 cgagatcttg tttgataccg tctcagtcgg atggaaatgg cctgtatcaa gtaaacaaag 2614501 cttatgattc gtcaaagcat aagctaaata aaattcatga gatccgacaa catatgattc 2614561 ggagccaagc ccgaacagct tgctctcgat tgaatcaaga ttatgttgtt cactgatctc 2614621 ctctgagaag atccgatcca gtgattcttt tagtctttta cgcggtgtca gcctatcact 2614681 cgggatatcc ttatagccgt cgggaatcca aatattcgtc aagcaaggtg ttcctaattc 2614741 tttcccgaag tattccccga tacggcggca agcgatgcaa tgcctgatcc aaaattctct 2614801 gatgtccgga tcagggtgtg aaagggtgag tccgtcagcc gctttctcat gcgaaaacaa 2614861 ggttggatta aaatctaaac cgagaccaag gttttttgcc catttcaccc agttttcaaa 2614921 atgctgcggc ttcaattcgt cacgttctac cgcttccctg tttgtttctg cgtatatcgc 2614981 atgcaggttt acgcggtgct ttccaggaat gagagaaaga gccttctcca aatctcttct 2615041 taattcttca ggagtttgcg cttttccggg ataattgccg gtcacgtcaa ttccgcctga 2615101 aagctcgccc ttatttactt caaagccttc aatgtcgtca ccctgccagc agtggatcga 2615161 aatgggcact tgctctaatt gccgaagcgc ctcttcaaca tcaattcccc atttttcata 2615221 tgcctgtttt gcactgtcat aattggcttt tatggtcata cggctctctc cctttatcag 2615281 tttttcaatc caaataaaaa acttccttta gatctatcgc aacaggactg aaatccgaat 2615341 ttgttttcat taatggcgcc atcgatttcc accatctttg gcaaacttcc gtgtccgcca 2615401 tctttctcca tttctcttca tcctctattt ctaaatatgc aaaaagcctg cctgtttcct 2615461 cgtctagaaa aatggaataa tggtgtgctc catgagcttt gagtgcttct gccatctcag 2615521 gccaaatgtc atcatgccgc tgtttgtatt cttcgtactt gtcttgatgg acaaacatga 2615581 tactggcttt tcttttcaaa ccttttcacc tcttcatcat ttagatagcg ctttcaaaac 2615641 agtttgctga aatgactgaa tgatcgtgct tctatcaatg tctttaggtg taaacacttt 2615701 gatcggaaag gaatttctga cgacttgccg ggcttctttt atgtctttga cttctttggc 2615761 agcaatcatt tgcatcaaaa gatttccggt ggcagttgcc tctatcggcc ctgcatatac 2615821 cgcttttcca ctcatgtctg ccgttaattg atttaagaaa tcattccggg ctccgccgcc 2615881 gatgatatga aattgctcga tcggtttttc tgtgattgtt tcgagctctt tgatggctat 2615941 cgcatagatg atggctaaat tgctgtagat gcagcaggca agttcgcctg cagtacgggg 2616001 aatcttttgg cgggtttgtc tgcaataatg ttgtatttcc tttatcatgt tttctggatt 2616061 caggaaacgt ttatcattta agtttataaa ttgctggaat ggttctgttt ttttggcttc 2616121 ttctgcaagc tgctgaaaag aataatctgc ttgtagctgc tgtttgactt cttgtatcac 2616181 ccacatgccg ataatgtttt tgagaaagcg aatggtgttg tttgcgccgc gttcatttgt 2616241 atagttgttt tctaaagcaa gatcagttat tatcggtgtt ttgttttcaa ccccgattaa 2616301 cgaccatgtt ccgctgctga tatacgccca gccatcattt acgcctggcg ccgcaatgac 2616361 ggccgaggcc gtatcatgtg ttgcgactgt catcaccttg cacgccggga gatcataatc 2616421 cgggaaccac tcatttctta gcttcccgag ttcacacccc ggttcagtga gcggcgcaaa 2616481 ttgctgttcc agaacagaca cggcttcaag caattcagga tcaagatttc ccgttgagac 2616541 gtttaaaagc tgtgttgtgg acacgtttgt gatttccgtt acagcttttc cggttaaaca 2616601 atagcctaaa taatcaggaa tcatcataat tttgtctgtc tttttcagca gctcacggtc 2616661 ttcttcaaac aattgataga tcgtgttgaa aggctgaaat tgtattcctg ttttttgata 2616721 aattgcggct tttgagaggg tatgttccag tttgtctatt gtgtgatctg ttcttctatc 2616781 acggtaggag attgcttccc gcaaccgatc gcctttttcg tccagtaaga cataatcgac 2616841 tgcccatgta tcaatgccta cggtgcagtg ttcataccca agcgtcttta ctttttgcag 2616901 tccttgcagg atttgtttta gcaaatgatc aatatcccat aagcaatgcc cgtctctttg 2616961 actgaaaccg ttagcgaacc tgtgaatctc ttgtatgtca agcttccctt cattcagttc 2617021 acctaccatg attctcccgc ttgatgcgcc tacatcaatg gcagtataaa tcatcctttc 2617081 accctctctt cgaaagagga acagctgtca ccttcacctt tttgtcctca agagctttta 2617141 ccgatgccgg atcaagtcca gaatccgtaa taaggcggct gacatcttgc agcgaggcga 2617201 tatgtgaaaa ctcgcggttc ccccatttgc ttgaatcggc catcaaaatg gtctggtccg 2617261 acctttcgat catccgtttt ttgagcagcg cctgccactc atttgaatca ctcatcccgt 2617321 tgtgtacgtc aaatccctta catgacagaa aggttttatt gacatgatag gtctcaagtg 2617381 aacgctctgc taacgggccg gcaaatgata atgatttttc cagcaaaatg ccgcctgttg 2617441 aaatgactga tatgttttct ttattgctga gttcaatagc tgctttcatt gagtttgtaa 2617501 tcacggtgag ctcaatgtca gggagtattt ttgccatgta ccaagcggtt gtgcttgcat 2617561 cgagaatgat tcggtctccg ctttttacat atttggccgc ttcgtgagcg atggcttttt 2617621 tttcgatgac attcgtgatt tcccgttcag aaaaatgaat ttctgattcc ttctgctgaa 2617681 tactgaccgc tcctccgtgg ctccggctca gtttatgttc tttttcaagc ttttcaagat 2617741 cacgccgaat ggtttcctct gtgactgaaa aaatgtcact taattcggaa acgcggatgc 2617801 ttgaacgcat atttactatt tccactattt tttgctgccg ttctgctact agcatcggta 2617861 acgcccttcc tcatatcgta gtccgtctta tatttttatc atagcatata tctaacgcgt 2617921 aaaagcagca gggacgccgc cgtctaccgt gatcatgcag cccgttgttt tttcggcttt 2617981 ggaagaagcg aagaatgcaa tggcttcggc aatatcctcc gggtaaatat tgacgagcaa 2618041 tgctgtccgt ttccggtaat gttcctccag ctgatccggt tcaatcccgt acgccgcggc 2618101 tcgttcctca cgccagcttg aaccccagat tgccgatcct tgaagaactg catcaggcaa 2618161 aacggagttg accctaatgc cgaattctcc gccttctgct gcgatgcatc ttgctaaatg 2618221 ggtttcaagc gccttaacag agctgtaggc agaggcgttt tttcccgcat aaactgaatt 2618281 tttcgatccg acaaatacca tgcttccgcc tctattttga tgtttcatct gtttaaacgc 2618341 ttcacgggct acaaggaaat agcctgttcc taaaacattc atattaagat tccattcttt 2618401 tagacttgtt tcgtcaaatg ggcttgatgt ggccagcccg gcattattga cgacgatatc 2618461 aatgccgccg taagcaagcg ccgctcgttc aaaagctgac tgtacgtctt cctcctttgt 2618521 cacatccatt ttgacagcca ttgcccgtcc ttttccgtat gcatcgttta tttccccggc 2618581 aattttctgt gcgccttcta tattcagatc agctacgatc acgtgccctc cctcagctgc 2618641 aaatcggcgg catgccgcac tgccgattcc gccggctcct ccagttatca gcgctacttt 2618701 tcgggaaaat tctgcttccg gcggggccag cgtgagttta tatagttcga gcggccaata 2618761 ttcgacatgg taggactcat tttcatgtaa agaaacaaat tgccccagag cggttgctcc 2618821 tttcattacg gcgatggccc tccgatataa agccccgctt actttagaca tcgcataact 2618881 ttttcctgta ttcaccattc cgattccagg aatcaatatc acccgcgggg cggattcaaa 2618941 gatttgatcc ccatcctgct gattgcgtgt aaagtaagcc tgatactctg atgtaaaggt 2619001 ctcgactcct gacttgatca gatctgcaag cttgtgcaca tcttgagttt ccggattcca 2619061 atcaatgtac agcggaaccc gttttgtgtg aacaaggtga tccgggcatg ccgcaccgat 2619121 ttgcgaaagt gctggcgctt ggacactgtt tacaaattcc aagacatcgt catgatcatc 2619181 ataggaaagg atcattttct tttcttcact tactgctcct ctgatcacag gcatgatgcc 2619241 tgccaagatt tgttttcttt tatcctccgg cagcggctga taccttttgc ctccgaatac 2619301 ctcatgctga ttgatacgat cgttaatata ctgctcggct tcttgaatga tggatatcgt 2619361 tttttgataa catgtttcag acgtctctcc ccaagtgact aagccgtgtt tctccattaa 2619421 tacaagctcg gcgtgggggt tgtttgctac gccttcagcg atcattttag acaaagtaaa 2619481 tccaggacgg acgtatggca cccatacaaa ccgatttccg taaatgtctt cagcgatttg 2619541 ttttccatta tccgcacagc atatgctgat aatcgcatct ggatgggtat ggtcaacatg 2619601 tttgtatggc agaaaagcgt gtaatagcgt ttcaattgaa gggcggggat gtttgctgtc 2619661 tatcatacaa tgagacaggt agtctaccat ttcttcatcg ggcatttggt cccttttaat 2619721 cagcgggcgg atatcatcta atttcaaacc ggaaaagtta tgcgctttca ttgttgccaa 2619781 atccgatccg cttcctttta cccacatgac ttctatttca cggcctctaa aatccttttc 2619841 cgttgttttc atagatgtat tccccccgcc ccagttgcag acagtgcggt ctgacccgat 2619901 cagattggac ctgtacacca attcctctac acctttaggt agctgtgcag ctcgctctga 2619961 atcccatata tgtttcacca tatttgatat tcctccatac ccttttattt gtatccgttt 2620021 tcattatata tgatttctgt ttgtttttga atcgtttttg tttatttttg ctttttaaca 2620081 aaaaaagaaa gcagcagata tgccgctttc tcgtttcatt atgattctat tttaaatttc 2620141 ttcgtaatgt cctgaagttc ttccgccatg tttgccaacg tttccgctga agagctgatt 2620201 tcttccatgg acgcaagctg ttcttccgcc gaagctgcga tatcctgaat gcctgctgag 2620261 ctttctttcg ccactgcaga aatatcttca acagcacttg acacttcctg tgatccggct 2620321 gacagttgtt caaccgtcgc gttcaagttt tgcaattcgc cggaaatttg ggttgtcatc 2620381 tcatagattt gtttaaagct ttccgctgtt tgatccgtaa tctgcaagcc ttctttcact 2620441 tcatgattca cggattggaa cattgaaagt gaggtgctga tttccctgac aatctcttga 2620501 attaatcctt caatttcctt ggcggagtct gctgattgta cagcaagttt tctaacctct 2620561 tccgcaacta ctgagaaacc tcttccgtat tctcccgctc ttgccgcctc aatcgcagca 2620621 tttaatgcaa gcaggttggt ttgatcagca atgccgttaa tcacattcaa gatgcttgtg 2620681 atgtcttgcg attttgtttc aaggcccttc acaaccgctt ccgctttttg aacggattgg 2620741 tcaattgttt tcatctggcc gactgtatgc tccaccagct tttctccgct gcccgctgcc 2620801 tcagaggact gaatcgatga tttcgtaatg gttgaagagg cttgagccac ttttgaaatc 2620861 ccctcgttca tttgagaaag atgatttgag cttgtttcca gtttctcgct ttgtgcctcg 2620921 ttgccatctg agaactgttc gatggcaagt gtaatatgtt cagttgcctt gcttgtttgg 2620981 gctgcgcttg ctgtcagctc ctcagaagat gaagcgacgt tttctacaga cgtttgaata 2621041 acgcctatta cagaacgcaa tgatgcagac atttcattaa agctttcgcc aagctggcca 2621101 aactcgtttt tcgagtgaat gtcaatgact tctgtgagat ctccgctgct gatttttgca 2621161 gacgttgaga caagttttct taacggcttg gtgatggcac ggataatata gagtatgagt 2621221 atgccgccga ttactattga cacgcataga atgataaccg cagtgttcag caccgggctt 2621281 gaagcatctt gcaattcact gacaaaatat gtgcccgcga ttttccagcc agtcagttta 2621341 tttgtcgtaa aggccatttt cttttctttg ccttcgaatg tatattcaaa tgagccttct 2621401 tttttggaat atacttggtt tgtccaatcg ccggaaccgg ttgtccccgg cttaatggtc 2621461 ggatgggcga tatatttttt gttgcctgtc gtaataaatg caaagccttc ttttccgatt 2621521 ttgattcttt ttgatgcagt aagcacttca tccaggttta aatctagcgc tataacccct 2621581 gaaccgtctt ttaattgttt tgaaattgtg acaacgatat ctcctgtcgc ttcatcggta 2621641 tacggttctg agaaaacagc ttgtcctttt tccgcaaccg cctgtttgta ccagtcacgt 2621701 cctgtcggat cgaaaccttt cggaacaccg ctatccggat atttataaag cttcttatct 2621761 tctgaggcag catagattgc gcctacatcg tcgttaagtg tcgtgtactg cttaaatttc 2621821 tctttcagta atgttttgtt tttgcctaac aatatgtctt tatcgactgt ctcactataa 2621881 taatctattg cttttacttt atcttctaat ttattttgca gcgtactgtt tagttcttca 2621941 acatttccct tcgcactgct tatgagctct ctgtctaacg cgttccaagc tgattgataa 2622001 ctgaaatatg ctaaaacccc aaccggcaaa ataagcactg ccagaaacgc agcgattagc 2622061 ggtttgctga tcgatggctg tttgatccat tgtatgaatt ttcccattct cgttgactcc 2622121 tcctttaaga taaatctaat atcgtcaaac taggataaaa ggtttaataa aaaaactaaa 2622181 aaaaacaccc aagcgcaaca agcttgggtg ttaaggctta ttattcaatt ttaaatcgtt 2622241 tggtcatatc ccgaagctct tccgccatag aggaaagggt ctctgcagac gagctgattt 2622301 cttccatgga agctagctgc tcttcagctg acgccgcgat atcttgtata tgcgctgagc 2622361 tttcttttga aatcgatgca atgtgctcag acgctcccga aacttcttcg gagctggcag 2622421 aaagctgctg aaccgtcgca ctcatatttt gcagttcgcc ggcgatttgg ttcgtcattt 2622481 cagaaatgcg tttgaagctc atttctgttt tatctgtgat gtcaagtcct gtctgcacct 2622541 cttgattgac agattggaac atgccgagtg atgtattgat ttccttcaca atttcgatga 2622601 ttaatccttc aatctctttt gctgaatctg ctgactgtac tgccagtttt cttacttctt 2622661 ccgctacaac ggagaagccg cggccgtact cgcctgcgcg cgctgcttca attgctgcgt 2622721 ttaaggcaag caggttcgtc tggtctgcga tgccgttgat cacacgcaaa atgtttgtaa 2622781 tatctttcga tttcgtttcc aatccgcgta cgacttgctc cgcttcttta acggacttgt 2622841 caatgacatt catttggccg acggtttgat gaacaagctt gccgccttca cttgcaattt 2622901 ctgtcgattg aacagatgaa tcagtgatca cttcagaagc ttgagccata ttcgtcaacc 2622961 cgtcattcat ttgataaatg tgctctgctg ccgtttcaat gttttcgttt tgtttttcat 2623021 tgccgttaga aaattgttca atcgccaatg taatgtgctc tgttgccttg ctcgtttgcg 2623081 cagctgatgc agtcagctcc tcagaggaag cggcaacatt gtctaccgaa tcctggatgg 2623141 cgtgtatgag agaacgaagt gacgacgcca tattgttaaa gcttttgccg agctcgccca 2623201 attcatcttt tgaacggata tcaatggttt ccgtcaaatc tccctcgctg atccgcttag 2623261 aggaaccgac aagctgtttc agcggtgttg taatcgaccg aatgatcaat gtcatgacga 2623321 taatccctat gataatagct gcggccaaga caattaaagc aaggtgaagg acaggctggg 2623381 ctgcctcatg gatttcatcc aaatacatgg tgccgccgat cttccatccc gtcaacttgt 2623441 ttgtgtcaaa ggccattttt ttcttatcgc catccatggt gtattgaaaa tcgcctttat 2623501 cagcactcaa catcttatcg agccagtcgc cttttaattc agttcctgat tgttcattag 2623561 ggtgtgcgac aacttttttg tccttcgtca tgataaatgc gtagccttgt gtgccgatgt 2623621 tgactttttt ggttgttttc agcagatttt caatcgtcat gttgattgcg ataacgcctg 2623681 aaccatcttt tgtctgctgg gcgattgtca caaccatcgt atttgtcgac gcggttttat 2623741 aagggtctgt gatcacgact ttccctttat ttgcaaccgc ttttttgtac cagtcgcgtt 2623801 caaccggatt atagccgctt ggcatcggaa gatccggata gcgggtaaag tgcccttttg 2623861 tgtcacttgt ataaatggat tctacatcct tgttaatgct gatatattgt gagaatttct 2623921 ctgcaatgct tgcattgctt tttgcattgt atttctcttt tgtcagccat tcgctgaaat 2623981 aatcagcact gttttctttt tcgccgatgc tggtgttaat gatttcgttt aattgctgta 2624041 cattttccaa tgcgctcccc atcatctgtc tgtcgagtga gctgctagcc gattgatacg 2624101 caaagatcgc caatatgaca accggtatga tgaggatcga cagaaaggaa acgagaagct 2624161 tccgtgtaat tgatctttgt tttatgagtt ggagtatttt tttcatcatt catttctcct 2624221 tttttatgct acccttcata tcggctggaa atgggtaaat atatacagca aaaaagaaga 2624281 aatttaacaa aagtaactaa tttcccataa ataaatagta ttttagacct attatttgtc 2624341 tactttaaat tgttttgtca gatcacggag ttcttcagac attctttcaa gcgtcagtgc 2624401 agatgaacta atctcctcca tggatgccag ctgttcctca gctgaagcgg cgatatcttg 2624461 gatgccatcc gagctttcct tagaaatggc agtgatatca tttgaagctg cggaaatttc 2624521 ttgagctccc gctgacagct cctcaaccgt cgcattcatg ttttgcagct cggaagcaat 2624581 ttgattggtc atttgcgata tatgtttgaa gctctgttta gtttcatccg tcatgacaag 2624641 ccctgtttca acttctttgt ttacggactg aagcacgttc agtgatgtgt gaatttcttt 2624701 tactatttca ctgatcagcg attcaatttc ttttgctgag tcagccgact gtaccgcgag 2624761 ctttctcact tcctcagcga cgactgagaa gccccggccg tattcacccg ctctggcagc 2624821 ttcaatggcg gcatttaaag ccaaaagatt ggtttgatcc gcaatgccgt tgatgacacg 2624881 caaaatattc gtgatatcct ttgatttgat ctccagccct ttcaccactt gttccgctgc 2624941 ttttacggaa tggtcaattg tgttcatttg gccggctgtt ttctggacga gtgtctcccc 2625001 tttgcttgac acttcggttg aatctgcgga tgtttctgta atcactgctg cagcccgcgc 2625061 cagctctgcc aatccgtcat tcatttcatt aatttgttcg gttgtcgttt ctattttctc 2625121 gctttggctt tcactgccgt ttgaaaattg ctcgatagcc atcgtaatgt gctcagtggc 2625181 tctgcttgtc tggtctgccg atgcagtcag ctcttcagac gaggaggcaa cgtgttctac 2625241 tgagtctttg atcccgtgaa tgagcgagcg aagcgagtgt gccatatgat tgaagctctc 2625301 actcagaacg ccgagttcat cttttgaatt gatttcaatc gtttcggtta gatcgccttc 2625361 actaattttt tcagcggatg cgacaatgcg tctcaatggc tttgtgatgg atcgaatcac 2625421 aaaataaatc gccgtcattc cagctccgat ggcaatcgcc agaacgattg aagccatgat 2625481 cagaaccctg cttgcagcat cgtgaatctc gtttgcatac atcgtgccgc tgattttcca 2625541 gcctgttgtt tggcttgttg caaatgccat ttttttcttt ttgcctttgt acgtatattc 2625601 aaagtccccg cttttatcct tgtagagctt atcaacccag tcccctttta gctctgttcc 2625661 cgctttttct ccggagtagg cgatgacttt cttgttttgg ctcaaaataa aagcatagcc 2625721 ttcttttccg atattgattc ctttcgcggt agtgactaag tcatcaattt tcatatcaat 2625781 ggcgacaacg cctgacccat ccaccgtttg acgggcgatg gtgacgacca tttttcctga 2625841 tgaaatcgat tcataaggct cagtgacaat tgttttgcct ttattggcca ttgcttcttt 2625901 gtaccaatct cgttccaaag cattaaagtc gcttggcatg tcagcgtacg gataacgtgt 2625961 gaagtccccg tctttgccgc ttgaaaatac cgcagcgaca ttatcattca tttggataaa 2626021 ttgtttaaat tcctgtttca gctctgtttt ctttttatcc tgaaattttt ctgctgtagc 2626081 ccaatcgctg aaatatgcga ggcttttttc agtagtgctg attttatcat caatgatgtg 2626141 atctaatatc tgaacatttt cctttgcgct ttgcgtcatc tgtacatcaa gtgaggcaac 2626201 tgctgattga taagcgctaa ccgaaagggc ggttatcgga acaattaaga tcagcaggaa 2626261 agaaataata agtctccttg caattgatga tctgcgaata gtggtgagtg tttttttcat 2626321 ttccttttga accttctttc aataatttac aaattatatc ggcggatctt cctttaaatt 2626381 acattgaaaa tggaggaaaa aatgaaaaat agttctaaat tcacctgtta aactaggact 2626441 ttattattgt ttaccatata aaaaaacagc gctttgatag cgctgttttt cggtttttac 2626501 tcgattttaa attgtttcgt cagatcgcga agctcttctg ccatctgcgc aagagtcgtc 2626561 gctgaggaac tgatttcttc catggaagca agctgttctt cagctgatgc ggcaatgtcc 2626621 tggatgcttg ccgagctttc tttcgacacg tctgcaatgc cgctgactgc tgctgaaaca 2626681 tgctgtgaac ggtctgacag ctgctcgacg gtggaattca tcgtctgcag cttgcccgcg 2626741 atttcgtttg tcatgctgaa aatgctctgg aagctttctt ttgtattgtc tgtgacaaca 2626801 agtccggact gtacttcctg attgacctct ttaaacatgt gaagagaggt gtcgatttct 2626861 gcgacgattt cttggatcag cttttcgatt tctttcgctg aatcggctga ttggacagcc 2626921 agcttgcgca cctcctccgc tacgacagag aagccgcgtc ctgactctcc ggcacgcgcc 2626981 gcttcaatgg ctgcatttag tgcaagcaga tttgtttggt cagcgattcc gttgatgact 2627041 ctcaaaatgc ttgtgatgtc ttttgatttt ccttctaagc ctttgacaac agcttcagcc 2627101 tgctgaacag attgattaat cgagttcatt tgtccgactg tctgctgcac aaacttctca 2627161 cccgttccgg cgatttccgt tgattggata gatgcctttg taatatctga cgatgtttgt 2627221 gagacttgct ggagtccttc attcattaag ttcagctgat gagagctgga ttcaaccttt 2627281 tcgctttgct cctcgtttcc gtttgagaac tgctcaatcg ccatcgtaat atgctcggtg 2627341 gctttactcg tctgcccggc agatgcggta agctgttcgg aagatgcggc cacattgttc 2627401 accgagtcct gaatagcgct gatcagagag cggagagatt gtcccatttc attgaagctt 2627461 tccccaagct ctccaagctc atcctttgaa tggatttcga tcgtttcggt cagatccccc 2627521 ctgctgatcg ttttcgatga ttgaacaaga cgttttaacg gttttgtaat cgaacgaacg 2627581 ataaacagaa ttaaaattcc gcctgccaca atggaagcaa tcagcacaat cattcctgtt 2627641 gtcagcacag actttgaggc atccttaatt tcatccatat acattgtgcc ggctattttc 2627701 caaccagtca gttcgtttgt agtataggtc atctttttat cttcgttatt aagagtatac 2627761 tggagttcac cgctgtcatt cgcatacatt ttggctaccc agtcgcctga aagcttttct 2627821 ccagccttat ggttcttgtg ggcgacatag gttttgtttt ttgttgcaat gaaagcataa 2627881 ccttcttttc cgaccttgat ttgtttcatt tgttctaaca atttatcaat ggtaatatcc 2627941 atggcgacaa cgccagatcc gtccttcagc tcctgtgcaa tggtaatgac catgcttccg 2628001 tcactcgcag ccacgtaagg atctgtcacg acaatttcac cgccggcctt catcgcatcc 2628061 tggtaccaag gccgttgtct cgggtcgtat ccttccggca atttttcttt tggcgcttgt 2628121 acataagtgc cgttatctgc gcccccataa attctggcta ctccttgatt aatagataca 2628181 tattgtgaaa atttagcttt gatctcttct tgatttgatt tccctttgaa tgcggatctt 2628241 ttaagagatt cactgaaaaa ggtgactgct ttcgcttttt ctcccagatc atttgtaaca 2628301 gttgtattaa atgtatcgac actgtttttc gcatttccca taatttcctg atccagcttt 2628361 ccgctggcgc ttcggtaaga gctaaattct aatataagaa tagggataat gagaatcgca 2628421 ataaatgaga cgattaattt ctttgaaata gacggtttct tcagccaatt gataaaagtc 2628481 ttcatgtcac ttgctccttc aggtttgata cagtatatat cggctgctta aaaaagtttt 2628541 aaaataaaaa atggaagaag ttctttttgg ctgtcttctg cctttttaac tttcattgcc 2628601 caagctcttt gcatatctta taaaaaacaa ggggggctaa acatgattat tgtatcagga 2628661 caattgctcc gtccccagga tattgaaaat tggcagattg atcaagatct gaatccgctc 2628721 ttaaaagaga tgattgagac gcctgttcag tttgattatc attcaattgc tgaactgatg 2628781 tttgagctta aactgcggat gaatattgta gcagcggcaa agacgctgca caaaagcggg 2628841 gcgaagtttg ccactttttt aaaaacatac gggaatacaa cgtattggag ggtttcaccg 2628901 gagggcgcct tggagctgaa atacagaatg ccgccttcaa aagcgattcg ggacattgca 2628961 gagaacggcc cgttttatgc gtttgaatgc gcaaccgcaa tcgttatcat ttattacttg 2629021 gccttaatcg atacaatcgg agaagataaa ttcaatgcca gctttgacag aattatttta 2629081 tatgactggc attatgagaa attgccgata tatacggaaa caggacacca ctttttcctt 2629141 ggagattgtt tgtattttaa gaatcctgaa tttgatccgc aaaaggcgca atggagaggc 2629201 gaaaatgtga tactactggg ggaagataaa tattttgccc atggtcttgg aatcttaaac 2629261 ggaaagcaaa ttattgataa gctgaattct tttaggaaaa aaggagcctt acagtcagcc 2629321 taccttctgt ctcaggcgac cagactggat gttccgtctc ttttccgcat cgtccgctaa 2629381 aaagccccat cgcctatttt ccggacgatg gggtttcaaa tgcctttcgt tttcgataga 2629441 agggggctgt gccaaaatat tggttcgcag cccactccat tttttcaagg tcatttcttg 2629501 tcacgattgg atcctggctg ctccatttga taaagcggac aaaatagtag cctttgatag 2629561 gaaccattgt aacttttgag tgaggccagc cttcaaatac aaactcaatt ttccctcttt 2629621 ttttataaga atattgaaga atgttcatat ctgtcacctc agtttatcaa gttacgttcg 2629681 gcaaagctcg gtacgtttac atccattgat taactatccc tcatgcaggc tttccggaaa 2629741 acaaagggtg aggcgcgtgt ctctttccct cgctttttat ttcgcatatg gacgaatgcc 2629801 aagcacgcct tcattcgata aagccgcagc gtgggcgggt gtgacaagcc ctccggctat 2629861 cggcgcttgt tcagcgatca tgcttttgtc ataaaaaaca gcctattatc ccatcatttt 2629921 gatatagcat gtccgggtgc gaggcccgtc aaattcgcag aaataaatgc cctgccacgt 2629981 tccaagaata agccggccgt tttccacaat gacatgctgt gaagctccga ccgtactcga 2630041 cttcatgtgt gcagctgtat tgccctccat atggcggtcc agctcatgtt cccacggata 2630101 tacctcatca aaccttctga gcatatcttt tttgacgtcc ggatcggcat tttcattaat 2630161 tgtaatgccc gcagtcgtat gcggacagta aatcagcgct gcgccgctcg ttatacctgt 2630221 ttcttgaaga aacgcttcca cctcccgggt gatatctatc atttcatctc gtttggttgt 2630281 tttgatttgc agtgttttca gcatttgttt ctcctttcgt ttgtccgctc tcatcgctta 2630341 attcgttctg tgttcttttt tttcctgtta aaccgctctc ataaacccga taaaacaaaa 2630401 aaactccagt ctaaggctgg agtttagcac catagatata ttcttgcttc atacggcttt 2630461 aagagtactg atgtcatatg cttgtgcggc tctgtttcaa tatttgacaa gacgagtgca 2630521 tctgatgaca atggcaatcc agagtgcctg aacaacgccg gtgttcctgt cagattggcc 2630581 gcaatcagtg cagtatggct ctcgtttttc cgaagatatg caaagatttg ctgatcttcc 2630641 ggtaaaatga gctcgtatgt cccgttaata aaaacatcat atgtttggcg cagcttgatc 2630701 aagcttttgt aaaaatggta aacggatgtt ttatcgtttt tttgcgcctc ggcattcagc 2630761 catttgtaat tctcattgat tccgatccac ggtttggcct cagaaaatcc ggcgtatgga 2630821 ccagcattcc attgcatcgg cgttcgcgaa ttgtctcttc cctttttcca gacaatcttc 2630881 atcacatcct cgtgtgatgt gcctttcgct gtttttgttt catacaggcg tttcaatgcg 2630941 acatcatcat agtcctcaat agatggaaaa gccacgttcg tcatcccgag ttcctgtccc 2631001 tgataaataa acggtgtgcc tttcatgaga aaataaacag cggaaagcgc ttttgcactt 2631061 tctttcaggt acactccgtc gtctccccac acagaaactg aacggggctg gtcgtgattc 2631121 tccataaaca aagcattcca gccgatccct tccagactgt cctgccagtc agttaaaatt 2631181 cgtttaaatg caacgatatc aatactttca ttgatctcta catcccacag gccgagatgc 2631241 tcaaattgaa aaatcatgct gaatatgccg tttttttctc cagcccaatc agctgcttct 2631301 tttgcagcga cgccgtttgc ttcaccaact gtcataatcg gatagcggga aaatgtgttt 2631361 tccttcagct ctgttaacaa atccataatg ccgtcagcat tcatatgata aggaaaggaa 2631421 gggacatagt ccagtccctt tggattcggc atgtcaggaa acccttcttt tttcttaata 2631481 tgcgtaatgg catccacccg aaatccgtca attcctttat caagccacca attgatcatg 2631541 tcataaacgg cattcctcac cttttcattt tcccaattca aatcaggctg ttttttatca 2631601 aaaaggtgca gataatactg gcttgtcttt tgatcatact cccaagccgg cccgccgaaa 2631661 atgctttccc aattgttggg cgtttttccg tttttgccgt ctttccaaat ataccagtcg 2631721 cgcttttccg agtgtatgga tgaacgggat tctatgaacc atggatgttc gtcgcttgtg 2631781 tggttcacaa cgagatccat aatcagcttc atatccagat catgaatgtc accaagcagc 2631841 tcatcaaaat cttccatcgt gccaaactcg cttaatatgt tttgataatc cctgatatca 2631901 tagccattat cggcattcgg tgaatcatac agcgggcaaa tccatatgac gtcagcgccc 2631961 agctctttta tgtaagaaag cttggttctg attccttgaa tatccccgat tccgtcgcca 2632021 tttgaatctt taaaactgcg ggggtaaatt tggtaaacta cggcttcctt ccaccaagcc 2632081 tttttcatac agccactcct tcccagtgta ccgttcttat atatcctatg tagaaaaagg 2632141 tctttacagc attgcttttt aagaaatgac ttgatgacac aaaaaacagc cgtttgttcc 2632201 ccggctgttt tttatcaaaa atcagttttt tttatttcta caaaacggat gtggtgatct 2632261 tcggcgtcga ggattttaaa ttcacagccc tccgcgtgta tcacatcccc tgctttcagc 2632321 tccatttttt gcgttagaag ccagcctgca atcgtatcaa tttcttcatt ttcaatcgca 2632381 atgtcgagaa ggtcattcac ttcgtctatt agcgcttttc catccatcac ataatggtgc 2632441 tcgccctttt tcaggatgtg cggtgtttca tcctgatcat actcatcgcg gatttccccg 2632501 acgatttcct cgataatatc ctctacagtg acaagccccg ccgttccccc gtattcatcg 2632561 acaagaatcg ccatgtgaat ccgctccttc tgcatgcgga ttaaaagctg ctgaacagga 2632621 atgctttcaa tgactctgat aacgggcctc atgatttgat tcagctttat cggctggccg 2632681 agaaaataag ctttaaacat atctttgctg ttgatgatcc ctaaaatatg atccttgtca 2632741 tctttgatga cagggtagcg tgtataccgt tcattaatga tgtgatgaat tgcctcttca 2632801 agcgactgct ccagagagat aaccgcaatt tctgtccgcg gaatcataat ctctctcgct 2632861 acccggttgt caaattcaaa aatcttattt acatagcgga attcagactg attgatttct 2632921 cccttttcat agctttcaga aaggatcagc cttagttcct cttcgctgat gacaacctga 2632981 tgctccttta ccgaatgaaa gccaaacaat ttcacaagaa aacttgcaga gccgtttaat 2633041 gctttaataa acgggtacgt gattttataa aaccagatca gcggctttgc aatccataag 2633101 cttacagctt cagctttttg aatagaaacc gttttcgggg caagctcccc catcaccaca 2633161 tgcaaaaaag tgacgatgat aaatgcaact acaaatgtga caatgtggtt aaacggttcc 2633221 ggtatgcctg tcattgtaaa taagggatga agaaaacgtt caaatgtagg ttcaccaagc 2633281 cacccaaggc cgagggctgt aatcgtaatc ccgagctggc aggctgataa atactcgtca 2633341 agattggaga tgattttatg tgcggctagt gctcggctgt caccgctttc gatgagctga 2633401 ttgatttttg aacctctgat tttgacgatc gcaaattccg ctgcaacgaa aacagccgta 2633461 atgccaatca aaacaaaaat ggcgatcaat tgtaaaataa gcaaaaaaag cccttaccat 2633521 aaatggtaag gggccacctc cttaacgtta attctcatca cgaccgttta agaaaatcat 2633581 cacaaaacga agtagttcaa acagggaaac cagggcggcg gccacatacg ttaaggcagc 2633641 agcactcagc actttattta ccccattttc ttcattgttt cggatgaatc cttctgacac 2633701 aataatctgc ttcgcacgtg aacttgcatt gaattcgaca ggcaatgtaa tcagctggaa 2633761 aaagacagcc gctgaaaaca gtatgatgcc aagcccgatc aaattcaggc tgccgagaag 2633821 catgcctcct aagaaaagca aaggagctac accggatgca aaattcacga ctgggaagat 2633881 tttatgtctc agcacaagcg caccatatga ctcctgatgc tgcaaggcat gtccgacttc 2633941 atgggaagct acggatatgg cggaaattga gcggccgtaa tagaccggct cagataaacg 2634001 caccacccgt cttgtcgggt cgtaatggtc tgttaaagtg cctcttaccg gttcgaccgg 2634061 cacgtcgtaa agaccgttta tatctaaaat ccgtcttgcc gtttctgccc ctgtacgtcc 2634121 gcttgaggct tccacttttg aatatttttc aaagttgctc tttactttaa attgtgccca 2634181 aaacgacaat cccaatgcgg ctattgttaa aaatataaac agcatttttt catcatcctt 2634241 tgttcatgat catttctcta ttacgattat tttaatgagt tttctttctc gtgtacagaa 2634301 atgcgctttt tcttccggct tggagcacac aatccaatca gcaaaaagaa caggcctgct 2634361 gaaaacaaat aaaaggcgaa actgccggcc agttctttca gaaaatgaag ccaggagaag 2634421 cttccggaaa agtgattata tgaattcaaa tcgaaaataa acaaaatcac cgcggatgcc 2634481 gccagctgcg taccgattaa aaccacgatc gttctttgaa agatcgtcat ctttttcatc 2634541 ctttttgttt tagtttatgg agaaatccgg ttttatatgt tttgtacatt ttttgaaaaa 2634601 catcaccgga agtgggacat actgttagaa aaaagcacgg gtgtgatgga agctatgaaa 2634661 gtgacgagtg aggaaaagga acagctgagc acagcaatcg accgaatgaa tgaaggactg 2634721 gacgcgttta tccagctgta taatgaatcg gaaattgatg aaccgcttat tcagcttgat 2634781 gatgatacag ccgagttaat gaagcaggcc cgagatatgt acggccagga aaagctaaat 2634841 gagaaattaa atacaattat taaacagatt ttatccatct cagtatctga agaaggagaa 2634901 aaagaatgaa atcaaatcgg atatttattt catggctcag gtggccgtta tttatccgaa 2634961 tcggggttat tattttatgt ctgattcttt tgttcggcca aatcatttat atacttgagc 2635021 ctaagcagtt cacttcggta ttcgaaggta tttggtgggc tgtcgttacg gtttctacag 2635081 tcggttatgg agactatgtg ccgcacactc cgctgggaca ggcagccgga atactgctga 2635141 ttttgagcgg agcaagcttt gtcacagcgt atttcgctac gttatcagcg gccgcattca 2635201 gcagacagca tcgctacatt gaaggaaaag ttgcttacaa aggccgggac cacatcattc 2635261 tgatcgggtg gaatgaaaaa acaaaccggc ttttgaagga ccttcagctt gccgcccctt 2635321 ccaaaacagt cgtactaatc gatgaatcct taacagaagg cccgcttatt gaaaacgttc 2635381 atttcatacg cgggcacgct gccgatgatg ggacactgaa acgggccaat attactgaag 2635441 cggaatcagt gatgattact gccgatcagt ataaaagtga aactgatgct gatatgctgt 2635501 cagtgctgac tcttttatct gttaaaggtc ttaatcccct tgcttactgc atcgtcgaga 2635561 ttttaactga ccgttttgtc accaatgcgg aacgggcagg cgcaaaccaa atcatcggaa 2635621 cttcagaatt tatcagccgg gcgatgctgc agcattacca agtcaagtta cggccgtcta 2635681 aacagcagaa cggaatcaag ctgacacttg atcagcatgt ggagcttctt gctgttcctg 2635741 acgaactaaa gggagcggct tacaaaacct gtgttctcta tttccttgat cacaacacaa 2635801 caattatagg catacaaaaa aaggaggggc cgatgctttc ccctcctctt acatacaagg 2635861 tgctcgaaac agatcaattc cttgccatct agtgtaacag aacatcctcc aattctttca 2635921 cgagagaggc gccgatatcc aaaaatgccg gatcaatttc cgcgtcccgc ctttccggtt 2635981 cggaaaattg attaaacagt gattggaaag gccctccctc ggcgtgatcg tcaacatccg 2636041 cctgaaacac ctgtctcagc ataaatggcg ttccgatccg gacggccgcc cctcgttcat 2636101 cgagactgcc ctgtaccgca ttgacgggaa ttcttaaaaa taaatagccg tctctatcat 2636161 caattttata atcaaagtag ccatgatcgt attcccagcc gccgtttatc acataaccga 2636221 gcggcttcat cacttgttcc agttcttgaa gcagaaaaga ctgcccatct atcgcggaag 2636281 gtattggtat catcagaatg cccctttttt cacttatcct gtcccgccga acaagacttc 2636341 attcagaggc gcctacatgg aaatcgttgt ttctttcgcg cggccaacag gaaagaaagc 2636401 gcattcaatt aagaagtaaa cagccattgc cgctgcaagc catacagctg aatcccaaga 2636461 cacataaaca accgttgcat agagtcctaa tttagtgaaa agagtatggg ttcgttttaa 2636521 atgcaaaatc cgatgtaccg catcggtaaa aagggcaagc ggcaaaccaa tgagaagaaa 2636581 ggagtggatg aaaaaatgtg acagcgtgcc gccaaagctt gaagaaaacc ctgtatacac 2636641 ggcatcaaag gagataagga aacttaaaat agctgcagaa aaaccggcaa tgatgagatg 2636701 tttaaccaat tgtttcatga acatcagcac ctttctgatt ttataaaaag ccgaccggca 2636761 aatgccagtc agctttctca cattaatctt ccagacgttt ttcaagctct gcttttttct 2636821 cttcaaagcc aggtttgccg agtaacgcaa acatattgac tttatacgct tctacaccag 2636881 gctggtcaaa cggattgacg ccaaggaggt aaccgctcat cgcgcaggct ttttcgaaga 2636941 aatatacaag gtatccaaaa gtatatgcat tcagctcagg aatgttaacg attaagttcg 2637001 gaacatttcc gtctgtatgg gcaagcattg taccttggaa tgcttttttg ttaacgaaat 2637061 caacagtttt accggctaaa tagttcaagc cgtcaagatc gttatccgct tcctcaattg 2637121 tcagttcatg tttaggcttc tctacgttca ggaccgtttc gaataaatct ctgcggcctt 2637181 cttgtacata ctggcctaaa gaatgaaggt ctgttgaata gttcgctgaa gaaggataaa 2637241 tgcccttctc atctttccct tcgctttctc cgaacagctg cttccaccat tccgcaaagt 2637301 attgaagcgc cggttcgtag ttgatgagca tttcaattgt tttgccctta ttataaagga 2637361 cattgcgaac aaccgcatat tggtatgctg ggttatcttc cagttcagat gttgcaaaat 2637421 ctttgctcgc atccagggcg cctttcatca tgtcgtcaat gttgacgccg ctgacagcaa 2637481 tcggcaagag acctacagct gttaaaactg aataacggcc gccgacatcg tcaggaatta 2637541 cgaatgattc aaagccttct tcgttagaaa gcgtttttaa tgcgccgcgc tctttatcag 2637601 ttgttgcata aatccgcgct ttcgcttctt ctttaccgta tttctcttca agaagcttgc 2637661 ggaaaatacg gaaagcgatt gcaggttcag ttgtcgtacc tgatttagaa atcacattaa 2637721 tagagaagtc aacatcttca agaagatcca tgacgtctct catataagat gaactgatgt 2637781 tgttcccgat aaaaatgact tgcggattgc cgcgttttgc ttttggcaaa gtgttataaa 2637841 acgcgtgatt cagcgcttca atcgctgccc gcgctccaag ataagaaccg ccgatgccga 2637901 caacaagcaa gacatcagag tcagatttga ttttttccgc gctttttttg atgcgcgcga 2637961 attcttcttt atcataatgt tcagggaggt ccacccagcc tagaaaatcg ctgcccgcgc 2638021 ctgttttctc atggatatta tggtgtgctg tttttacaaa gtcccgcagg tatgtaagtt 2638081 catgttcgtt gaagaaagtc aacgcttttg agtagtcaaa gcgtacatgc gtcattgctt 2638141 gtccctccat aacggtataa tgttttcatc tttcacttta tatgaactta tctgtgaaat 2638201 caagtcaaga agaaagggcg gaatgactgg attccgccct ttgggtttat agagacgcgc 2638261 gaaggatggc aagcacgtca tctttgttca gtttttggaa gttgccgaag ccgccgtgtt 2638321 ccatttcctt ggctgcgata tcagcaatca gctcaagctt ttcttctcca atattgtaat 2638381 cagcaagacg agaaggtgca ccgaggcttg tccagaacgc agacagttta tcgattcctt 2638441 caagcgcaat ttctttatct gttttgcctt cagtatcaat gtcaaacatg ttgagcataa 2638501 ggtttttaaa acggcctaca tttgtatcaa gcgtgtatct catccaattt gggaacagta 2638561 ttgccaaacc gcccgcgtgc ggaatatcat atacagctga aacagcgtgt tccattgtat 2638621 gagaagccca gtcaccgaag tatcccattt ggagcgtgcc gtttaaagca atagtaccag 2638681 catacaaaat cgtttcacga agttcgtagt tttccagatc ttcaagaagc ttaggagctg 2638741 tttcgatgac cgtctgcaaa acagcaaagc acattctatc ctgaagcggc gtgttttcaa 2638801 cattatggaa gtattgttcg aatacgtggc tcatcatgtc aaccatgccg tatactgttt 2638861 gattttctgg aacggtgaac gtattttcag ggtctaaaat agagaaacgc ggatgagtga 2638921 cattgctgcc ccatacaaat ttctcgtttg tttcccagtt tgtaatcacg gaatcagggt 2638981 tcatttcaga ccctgttgca gcaagagtta aaacagtgcc aaacggcagc gcatcctccg 2639041 ctgttacttt tttgctgaaa atatcccaag cgtcaccgtc atatttgacg ccagctgcga 2639101 ttgcctttgt acagtcaatc acactgcctc cgccgacagc aagcagaaaa tcaatgtcat 2639161 gctctctgca aagtcctatg cctttttcca ctgtcgcaag acgcgggttt ggctctacac 2639221 ctgacagctc atgaacaaca gcgccctctt cttttaaaat gcctgtgact tgatcataaa 2639281 ggccgttgcg tttaatgctg ccgcccccgt aaacaagcag tacattcttg ccgtatcgtt 2639341 tgaattcttt tcttaattgt tcaagctgac cttttccaaa aatcagcttt gtcggattat 2639401 aataagtgaa attttccata gtaaaacctc caaatgatgc tggtaaaaaa cagattttcc 2639461 attgtaacat aagttgacaa aaaagaaaaa gggaagcagc caaacggcta tttccccttt 2639521 ttttatagtg atgctttcaa aattgacagc acatcttctt tgttgagtga tttaaattgg 2639581 ccgaatgtac cgttagccat tgccttgtca gcgattgtgt caagctgctc atcattaata 2639641 tcataatcag caagacggtt cggagcgcca agacttgtcc agaatgcgga cagcttatcg 2639701 ataccttcaa gggcaatttc ttcatccgtt ttacctgctt cttcaacatc aaacacgcga 2639761 actgcaagct gtttcatgcg ggcagggttt tcagacaatg tgtgtctcat ccaattcggg 2639821 aacagaatcg ccagtccgcc ggcatgcgga atatcataaa cggctgatac tgcatgttca 2639881 atattatgag tagcccaatc ccctcttgcc cccatagaaa gcatgccgtt taatgcgatt 2639941 gttcctgtgt acaggatcgt ctcacgcaat tcgtaatttt cgagatcatt gatcagctta 2640001 ggcgctgttt caatgactgt acgcaaaagt gattcacaca tgcggtcctg atacggcgtg 2640061 tttgatacat gatggaagta ttgttcgaat acgtggctca tcatgtcaac catcccgtag 2640121 atcgtgtggt ttttaggtac ggtgaatgta ttcaccggat caagaatcga gaatttaggg 2640181 aatacgagcg ggctgcccca gccgtatttt tcttttgttt cccagtttgt aataacagat 2640241 cctgagttca tttctgaacc agttgcagcg agagtcaata ccgttccgaa tggcaaagca 2640301 tcttttggct gatgcttttt cgtaacgata tcccacgcat caccatcata cttcgctcct 2640361 gcggcaatcg cttttgtaca gtcgattacg cttccgcctc cgacagccag caagaaatca 2640421 atgttttgtt ctttacagat ggcaacacct ttattaacag tcgacacacg aggattcggt 2640481 tccacacctg ctaattcatg cacggtcgct ccggctttat tcagctgttc aatcacttga 2640541 tcatacaggc cgctgcgttt aatgctgccg cctccgtaca caagcaatac gttttttccg 2640601 taaggtttga gttcctccgg aagtctttcc acttcgccgc gcccgaaaat taatttggtc 2640661 ggattccagt atgtaaagtt ttgcatgaca tctcctcctt agatttttta ttatgcagaa 2640721 tgtcctcacc acatgtaaag caatcagctc tcaccgatca gcataccaga tggttttatt 2640781 ttgcaaggtg ctgggaaaga agctgatata agcgagggca ggccagcttc cctcatatgg 2640841 agaatgcatg tatagattct ccaatatgtc acaatctata actgttttaa taattcatgg 2640901 aggaggttgc aaaacatgag taccattcaa agaatttgtc ttgtattaac catcattggc 2640961 gccattaact ggggactgat cggatttttc caatttgact tagtagcggc tatcttcggc 2641021 ggccaagggt cagctctttc ccgaatcatt tacggacttg tcggaatcgc cggcttaatc 2641081 aacctcggtc tgctatttaa gccaaacgag gaaagatcac gtgaagaagc agcaaatcct 2641141 gaaatgcgat aggatatcaa tcacgctgaa ataggatttt gcatgaaatc aaaagcaccg 2641201 aacattcctg tccggtgctt ttttcatgct tattttttga taaggtcttt gcggttggac 2641261 atttcgatcc actcttcaag cttatctttt aatgtgttga aaccttgtgg tgtagaagct 2641321 tcttcgctta cttgagcagc tttaggtttt cttggtttgc tttctttttt ctcaggcgca 2641381 gcttgtgtcg cacgaattga aaggctgatt ttgccttttt cttcatcaac agcaagtact 2641441 tttacttgta cttcgtcgcc aactgaaagg tgctcgttga tatcttttac gaaaccgtga 2641501 gtcacttcag aaatgtgtac taaaccttga gtttcttcat ctaatgcaac aaacgcacca 2641561 tacgcttgta atcctgtaac tttaccagtg taaacactgc ccacttcaaa ttttgctgcc 2641621 attcataaca actcctaagt taaattaaat atctgtttat acgcaattta aaattatatc 2641681 acacatgtct tatttccgca aagaaaactt ttttataaaa aatcaggttt atgcacagca 2641741 aaaagggggt aaactgaaaa taccaaaggc tttctagtat tccccccttt tattggatgc 2641801 gaacaaaagg ttcgtatctt tttttatgtt gttttgtgca ggaagcgttt cattctgact 2641861 aacgcttctt gaagctgttc aatcgaggtt gcgtatgaac aacggatata tccctcaccg 2641921 ctcggaccaa acacacttcc aggaacaact gccacttttt cctgcgtcag tagctcctcg 2641981 gcaaactgtt ctgaactcat tcccatgctt ttgatagatg gaaaagcata gaaagcgccg 2642041 cccggatgat gacagctgag accgatttca ttgagcgatt ctacaaacag attccgtctt 2642101 cttcgatagc tttttttcat tttttctacg tcttccatgc cgttcttcag gccttcaagg 2642161 gcggcaaact gcgccattgc gggcgcgcac atcatcgcat actgatgaat tttaagcatg 2642221 gcatcccgaa gcaaggatgg tgccgcggca aaaccgagcc tccagcccgt cattgcaaat 2642281 gcttttgaaa agcctgagat gactaccgtc cgttccttca ttcccggtaa tgccgctata 2642341 cttgtaaatt cctcatcata tgtcagctcc gcgtagatct cgtcggctaa gacgatgaca 2642401 tcatgttttt tggcaaactc agcaatctca ttcagctctt ccttcgaata aaccgaacct 2642461 gtcggattcg atggtgagca gatgagaatg gcctttgttt tttcagtgac tgccgcttca 2642521 aaatcagcag ccgttgcttt aaatcctttg tctgccgttg tatgaacgtg aaccgggata 2642581 ccgcctgcca aagaaacaag cgcatcgtac gcaacaaaac acggctcagg aatgatgact 2642641 tcctcacctg gattcacaat ggcgcggatc gcaatatcca aagcctgact tgcccccact 2642701 gtcacaatca gctcattatc tggcgagtag ctaaggtcaa acctgttgct caaataacgg 2642761 ctgatttcct cccgcaatga gtataaaccc gcattggccg tgtatgacgt atatccttgt 2642821 tcaagagaga gaatgcttgc ttcgcggaca ttccatgcgg taacaaaatc aggctcgccg 2642881 acgcctaaag aaatgacgcc ttccatcgtt gccgccaaat caaagaattt gcggatgccg 2642941 gatggtttta tttgttgtac atagtctgat aaatacgaag tcatttacgg tgacaccacg 2643001 attcttttgt cgtcgtctcc tgtttcaaac actttgccgt catgcttgta ttttttcagg 2643061 ataaaatggg ttgtcgtaga tacaactgaa tcaagcgttg agagtttatc cgaaacaaaa 2643121 cgcgctacgt cagacatcga attgccgcga atcacgacag acaaatcgta tacgcctgac 2643181 atcaggtaaa ctgattcaac ctcttggaat cggtaaatcc gttccgccac ttcatcaaaa 2643241 ccgacgcccc gcttcggcgt tactttgacg tcaatcatgg ccgtaacgcc ctcatgtccg 2643301 tcgacttttc gccagtcaat catagcggaa taatcgataa taaccttttc tttctccagt 2643361 ttgtcaataa ttgttttcac ttcatttaca gggatgcccg ccatctttgc gattgtttct 2643421 aaatcggcgc ggctgttttc gtctaaaatt tctaatattt ctgtttcttt ttctgtcaat 2643481 ttcatttgat tcacaccttt gcaatgtcaa gaaatctcat gacattatat cacgtttttt 2643541 gacgaatgct aagaaaaaac gaggagaaac ttccgctaga attgacaatt tcagggcata 2643601 atacaaccat caaaaaaagg gagtgacaca gaatggaggc ggtttcacca ataaggcggt 2643661 ttacggtcga tggagtcaat gtatactacg aacattatca aaatcccggc aggcaaacgc 2643721 tggtctgcgt acacggtttt ttatcatctg cattcagctt cagaaaagta attcctctcc 2643781 ttcgggacaa gtacgacatc atcgcgcttg atttgcctcc tttcggccaa tctgaaaaat 2643841 caagaacgtt tatctatacc tatcaaaacc ttgctaagct tgtcattggg attttggagc 2643901 acttgcaagt gaaacaggct gtgcttgtcg ggcattctat gggcgggcag atatcgctgt 2643961 ctgctgctct ccaaaaacct gagctttttt caaaggttgt gctgctttgc agttcagggt 2644021 atttaaaacg ttcacacccg acgattattt tcgggaccca tatcccgtat tttcatcttt 2644081 acatcaaacg ctggctctcg aaagaaggcg tgatgaaaaa tttattaaat gtggtgcatg 2644141 acaaatcgct gattgatgag gagatgattg acggctatgg cagaccgttt caggacgagc 2644201 agattttcaa agccatgaca aggtttatcc gccacagaga aggagattta gaacccgagc 2644261 aattgaagaa aatgaacaag cctgctctat tgatttgggg cgaggaggat cgaattgtcc 2644321 caatggagat cggtaaacgg ctgcacgcag atttgcctaa ttccgtgctg tactcacttg 2644381 gccagaccgg acatctggtg cctgaagaac ggcctgaact tatttctgaa cacattgctg 2644441 attttatcaa ataacaaaaa aaccggtgct gaaccggttt ttttaaggcg tgcaggagct 2644501 gctgttttta atgaataaaa gctggccagc cacttcccgg cagctggcga tcggcagcgt 2644561 ttgttcaaaa gaagtttcaa atatttgctg aatgcttttc gccagcaagt cgggatcgtt 2644621 ttcatcatag actgcctgca cgacatcaac agcctccgtt tcgtaaaact cttctccata 2644681 tttaaacggg tcccatttgg caatgatctt aatcatttcc ctgaccgcat gactttcttc 2644741 catattcatc accgcttata ataaaatttg cagttctatc ttatcatagt gaagcttaga 2644801 agaataaaca tacatgaggg ggtaacagaa tgaactttga taaacgagaa gaacgccttg 2644861 gcacccaatc ggtcaaatgg gataaaacag gcgaattatt tggcgtgaca gacgccctcc 2644921 cgatgtgggt ggcagatatg gattttcgcg ccccggaagc gataactgaa gcgttaaaag 2644981 agcgtcttga ccacggtatt tttggttata caactccaga tcaaaaaacg aaggatgctg 2645041 tgtgcggatg gatgcaaaac aggcacggct ggaaggtaaa tccggaaagc atcacattca 2645101 gccccggcgt tgtaacagct ttgagcatgg cggtacaagc ttttacggag ccgggcgatc 2645161 aagtagttgt tcagcctcca gtttatacgc ctttttacca tatggtggag aaaaacggcc 2645221 ggcacatttt acataatccg ctgctagaaa aagacggcgc atatgcaatc gattttgaag 2645281 atttggagac aaagcttagt gacccaagcg ttacattgtt tattttatgc aatcctcata 2645341 acccttctgg gcgttcatgg agccgggaag atttactgaa gctaggcgaa ttgtgccttg 2645401 agcatggcgt cacagttgta tcggatgaaa tccattccga tttaatgctg tacggacata 2645461 aacacacgcc gttcgcttcg ctctctgacg atttcgctga tatttccgtg acatgtgctg 2645521 ctccaagcaa aacatttaat atcgccggat tgcaggcttc agcgatcatt attccggatc 2645581 gcctgaagcg cgccaagttt tccgcaagcc ttcagcgaaa tggtttaggc ggactgaacg 2645641 cgtttgccgt cactgcaatc gaagccgcgt attcaaaagg cggaccgtgg cttgatgaat 2645701 tgatcactta cattgagaaa aacatgaacg aagcggaagc ctttttgagc accgagctgc 2645761 caaaggtcaa aatgatgaag ccggatgcat catacttgat ttggctcgac ttcagcgctt 2645821 acggcttgtc cgatgcagag cttcagcaaa gaatgctaaa aaaaggaaaa gttattttag 2645881 agcccgggac gaaatacggg cctggcggag aaggatttat gcgcctgaac gccggatgct 2645941 ctcttgcaac cctgcaggac ggcctgcgcc gcatcaaagc cgcattatcg taaatatagc 2646001 tgtaaacgcc tttacgtctt catttgtaaa ggcgttctta ataaaggaat tttatatttt 2646061 acttctaata tttagtgtta taatagattc atattttata cgaaaggatt tcacacgaat 2646121 ggaaattcta aaagactatc ttctgcacat ctgctttatt ttgtttccta ttcttcttta 2646181 ccaagtgttt tggcttggaa aacctgcgat tcttgtgcca aaaataaaca gcggtttggt 2646241 cacgctcttc gcctgcggcg cctccgtttt atgcattatt ttcccgattc atgaaatgga 2646301 ctacatacaa tacggccttc agatgattcc cgttatcatt tgtttatttt acattagtac 2646361 cgcttccgga cttacagtcg ccgcatctgt cctatgtttt gaactgcttt tttacgaacc 2646421 ttccgcaatg tttgttttca ctttgctgcc ttttcttatc attatcccaa tcttatttca 2646481 gaaaaaatgg ccattcatgt ccaaagcgaa aaaactgctg ctgtctttat tgatcagctg 2646541 cgtggagatt ttcctatttt tcgcctcaag ctggattctt tccgccttga atattttaaa 2646601 ttttcaaaaa tcaggaattt tcgtttacga ggcggcagtc tcagggcttt tccgctccag 2646661 tgttcttcta ttaagcatct atattatcga aagcatcgcc gaaaatatcg ccctgcgttc 2646721 acagcttatc cattctgaaa aaatgacgat tgtgagtgaa ctggcagcga gcgtcgccca 2646781 tgaggtcagg aatccgctga cagttgtccg cgggtttgtc cagctgcttt ttaatgacga 2646841 aaccctacaa aacaagtcga gtgcggatta caaaaagctt gtactgtcag agcttgaccg 2646901 ggcgcaaggc attatcacaa actatctcga tatggccaaa cagcaattat acgaaaaaga 2646961 ggtttttgac ctatctgccc ttatcaaaga gacaagctcc cttatggtgt cgtacgccaa 2647021 ttacaagtca gtaaccgtcg aggctgaaac agaaccggac cttttgatat acggagacgc 2647081 aacaaagctg aagcaggctg tcatcaacct gatgaaaaac agtattgaag cggttcctca 2647141 cgggaagggg atgatccaca tatcagccaa aagaaacggc catacgatca tgattaacat 2647201 cacagacaat ggggtcggga tgacagacca tcaaatgcaa aaactcggcg aaccttatta 2647261 ttccttaaaa acgaacggaa cgggactcgg cctcaccgta accttttcca ttattgaaca 2647321 tcatcacggg accatttcat ttaacagcag cttccaaaaa ggcactacgg tgaccattaa 2647381 gcttcccgct gatcttcctc actagcaaat cgattggaac tttaatagaa taaatgcgag 2647441 gtgatgacag atgagcacgt ttgagacagg ctctatcgtt aaaggatttt acaaaacagg 2647501 tgtatacata ggagaaatca cggcttgcag gccgcagcat tatttagtga aagtgaaagc 2647561 ggttcttacc catcccgctc agggagacct tcatcatcca aaacaggcgg atgtgccatt 2647621 ttttcatgag agaaaagcgc tcgcatatgg tgaacagacc aatatccccc accatatggt 2647681 gaagccttat gacggtgaag tgccggatta taccgaatct ctgcgggagg cgacagcaca 2647741 gatgagagcc aaattgaatg aggatggttc ggagtgggca aagcgctccc ttcataatct 2647801 ggacatttta gaaaaagaat attttaaccg gccataaccc agtctgacaa aagattgggt 2647861 tttttacgtc gcgcgcttca acagttcggt taaatcgatt ctctcgccga ttgtgggcgg 2647921 ttttggcttt tcgagatact gcttatcctg ctcaacaagc ttaaaaagtt tatatgctgt 2647981 gagagcatca tcaagcgctt tatgatgggt gccggttccg gaatctccat actcttcggc 2648041 agctttccat aaacccgtca atgtccggtc tccaaaaaag tttttgtatt caagcgataa 2648101 atctctcatt tctcccttaa acgggaaagg gatatggtta aacatacagt tttgcttcag 2648161 cactttcata tccatgtttc cccacgtaat aattgtgctg tttttctcag gatccagctc 2648221 gtttagttta cggatgaaat cctcgaatct cattccttcg tctacctgtt tttgggttat 2648281 ttttaaaaat gatttgcagc gtttcgtaag cttcgggaac tttttcggtc taacatagct 2648341 agaaaacgtc tcaaccactt catcatcaat cgactttaca attccggctt caatgatttc 2648401 cgggaagaag ttttgaggac tgtactttcc atcaggcatt gtaaattcga aatcaataat 2648461 gagtaagctg tttgtcgtca ccttttacac ctgcctttcc tccgatcaga aaatgctatc 2648521 tttatagtat atcaattccc cttctcgaca tttcttcatt ttctaaaaat aatgaatttt 2648581 cccagccgct tcgtttcttt taaattgtga atcgtttctt tataattagt aaggaacccg 2648641 aaataataag aaggtgatgt tatttctatc cgtaagaaaa actttgtcat tgtgtggctg 2648701 gcgaactttt ttgtctccgc tagcacaacg atgatcgttc cttttctctc cttatacatt 2648761 gagacgctca gctctttttc aaacggcttt gtgcaaaggt ggagcggcta tgtgttcggc 2648821 attacatttc tcatggcgtt tttggtatcc ccgttttggg gacggttcgg agacaaacgc 2648881 ggatacaaga aaatccttat ggcaaccgga acaggcattg ccctcagcat tttcttcatg 2648941 ggctttgtta catcggtgta ccaattgttt tttctgcgta tggcaatggg tcttgtaacc 2649001 ggattcatcc cgacatctct tgcgatgatt tcggcacaga ctccgaagag ctcagctggc 2649061 aaaacactcg gcacgctgca aatggggcaa gtgtccggaa gcttgttcgg cccgcttttg 2649121 ggaggcatgc ttgctgatcg tttcggcttt acgtatacct tttttatcac atcctttgtg 2649181 attttctcgt ctgttcttct cgtgttattt ggtgtcaaag aaaagcatct tgcagagaaa 2649241 acagccaaac gtacgtctta ctcgagaaaa gaagtgctct cctatatttt tcaccatccg 2649301 gcgctgtggg tcatgatgct gttaaccatg ctgattcaaa caggcaattt cagtatccag 2649361 cccctgctcg ctttatatgt aaatgagctg cacggacctg tcaatcttgc ctttttctcc 2649421 ggcatggcat tttcagcaac ggggctcgga agtttgctgc tggctagaaa atggggtgat 2649481 ctgggcgacc gctacggcca ccgccgcatt ttaatcggac ttttgctcgc cgcctctttc 2649541 ttttttattc cgcaggcgct cgcgtcctca ctcagcgtgc tccttgtttt cagattttta 2649601 ttcggaatgg cgatgggcgg tttgctgcca tgcattacgg cagcgatccg cgttcaggct 2649661 cccggcagca ttcaaggtga agttctcggc tacaatgtca gctttcgctt tttaggaaac 2649721 gtgctcgggc ctctgctcgg cggaatcata tcgagccatt ttaccatttc ggccaccttt 2649781 tacgtcacgg cgtttctctt tttcgccggc gcctgcatgc tttggatcat gcagaaactt 2649841 cggaaagatt cttatgccaa agcaagctga ttccgagaaa aaactaagga atcttctaaa 2649901 tttaaccttc tcgtaatctc aaaagaatgg tacgatatgg ctagaattta ggagaaaaga 2649961 gagtgaccat gttacgaaaa ataatcggat ggattttgct cctttgcata atcccattgt 2650021 ttgcatttac agttatcgct tccggaaaag aagtaaaaca aatgaagtcc ctggatcagg 2650081 tgcttgataa aaatattgat ctgaaagata tcagccttgt tcagaacagc tacatgtatg 2650141 acagggacgg ctcccttgtc tcggaaatcg tcagcgacca cgaaaaccgt gtgctcgttc 2650201 catttaacaa gattcccgag gaagtcaaac agattttctt aacatctgag gaccgccatt 2650261 tttacgagca taaaggcttt gactttatgg gaatggtgcg ggctactgct tctaacgtaa 2650321 aagacaagaa aattgaccag ggtgccagca ccatcacaca gcagctttca agaaacttgt 2650381 atttgagcca cgaacgctcc ttcagccgca agctgacaga gctcgcgtat tcctatcagc 2650441 tggagaaaaa atatacgaaa aatgaaattc ttgaagctta cttaaatacc atttatttca 2650501 acaacggtgt ttacggcgtc ggttcagcag ctcaattcta tttcagcaaa ccgctgaaat 2650561 ctctcacagt gggagaaatg gcttttatct gtgctatacc taataaccct acattatatg 2650621 atcctctcaa gcattttgac tacacgaaaa gccgtcaaga acgtttactt aaagggctaa 2650681 aagatgccgg ggtcattacg gacaaagagc tgaaaaaagc cgtaaaacaa aaaatcaaac 2650741 tggatgttga aaaaagagaa gacaaatatc ctgactacgt ttcctacgtc aatgatgaat 2650801 tcactcagct ggtgtctgaa tcagaaggct ttgataaacg ccttcaaaaa gcatcaggaa 2650861 aacaaaaaga aaagatcgag aacgagctgt ccgcaagagt cagcacgctg atgaaagacg 2650921 gagtgaaaat ttatactgca cttgatccgt acatgcaaaa tcaagttgtg gcacaaatga 2650981 attccaagct cccgtatgcg gacgtacagg gcggagcggc tgtgattaat caccagacgc 2651041 atcaaatcat tgctctatcc ggcgggaaaa actatcaaaa atatgacttt aaccgcgcct 2651101 accaggcgta caggcagccg ggttcatcca ttaagccgct tcttgattac ggcccttata 2651161 ttgaacagac cggcgcgaca acaagcagca ccattgatgc cagcaagttt tgcagcaaag 2651221 actactgtcc gcaaaactac aataaccgca cttacggcac agtgacgctt gatacggcgt 2651281 ttaaaaattc atataatacc ccggctatta gaatgctcga ccgcgtcggc atccaaaagg 2651341 cattcagtta tattgagccg tatcattttg ccaaacttgt cgacagtgac tatcttcttc 2651401 cggcggcgct tggcggattt acaaacggca tgacgcctct tgagatgaca aaggcttata 2651461 cgacattcgg aaacagcgga agctatacgc cgagccatgc gattacaaag gtgacagacc 2651521 ttaaaggaaa aacactttat aaatggaatg ataaagcgac tcaaatattc agcgtccgca 2651581 cgaacatgca gctgaaaaaa ctgatgtctt ccgttgtgaa aagcggaaca gggaaaaaag 2651641 catatttcaa tgcgccttac atcggcggta aaaccggaac atcaaatgat tatcacgata 2651701 tgtggtttgt cggcctgact gatacgtata caatgggtgt ctgggtcgga aaggatacac 2651761 cgaccagcgt tgaatatctt cacagcatca gccctcagct ttccatctgg aaaggaacgc 2651821 tgcaagcggc ttattaaagg atcggagggg atatggagtg acttcagaac aaattccaaa 2651881 tcgcgttttg ctgtttgacg gtgtctgcaa tttatgcaat ggcgccgtgc agtttatcat 2651941 taaacgtgat ccggacggat tgatttcttt cacatcgctg cagtcggaaa caggacagag 2652001 cctgctgaaa aaaagcgggc ttccgactga tcggtttgac agctttgtct ttattgaaga 2652061 cggccaagtg tacacaaagt caactgcagc cattaaggtt ttcaggcatc tgcgaggccc 2652121 atggcggctc ttcgtccttt ttttcgcagt gccgaagcct gtcagagata tggtctattc 2652181 tttcattgcc aaaaaccgct ataagtggtt tggcaaaaaa aatgaatgta tgctcccctc 2652241 cccttccatt aaaaaaagat ttttaccgta aataaaaaat ggctaggaag ctagccatca 2652301 cagattgttg acaaaatcct aaaacggctt cgttttagga ttttgtcatc tattcagcgt 2652361 gattgaaaac ttttgaagtt gtgaaacggc ggaaacctga gaatctagcc gccgtttcat 2652421 tgcgtacaga gcacgaagcg caaatctgac caccaaacgc tgaaatggct agcttacaca 2652481 ggtaagctag ccattatgct attataaagc ttgataaata tgaacagaat accgataaca 2652541 aaggtaaacc aaaacagcag ttccaataga atgaatccaa ctaatgacat gagagaaagc 2652601 gtcgaataaa tccggtatac ggtaaacaca aagtaagcga gcgtgacgac cgcaaaccag 2652661 atcacaatcc aaatgacatt ttgcaagagc acaaaggata aaatcccgcc gcccaaataa 2652721 atcatggaac ccattctgag ttttttcagg ttgttccctt ccggatcatt agcaaaaaac 2652781 agcaatgaca gctcggtcac ggtatttgca attaatttca gagcggacag aaccataaaa 2652841 tataaaagtg caaaggcagc aaataacgca agcctgattc ctttctctga aaaataatcg 2652901 agcattccat catacattcc aaatgaagac agcatcttca acgcataaag tgaagttgag 2652961 atggataagg acgaactaaa aagcaggatc gcaatcagcg gaaaatatcc tgtcaaataa 2653021 gtatttttca tataaaaaag tccctttcta taatctacct catttattat ggaggactta 2653081 aaacacattg acaagataaa ttattccatt ttttctcctt tttacgaatt acgggcccaa 2653141 atcttcacaa agcagcattt tgagagtaaa gtagtacgca ggaatcataa aacgtaagga 2653201 agttttatat gaaaaaaaca ttaaaactgc aaaccagact caccatattt gtttgtatcg 2653261 ttgtattaat cgcattgctc attacgtttt ttacagtcgg tgcccaaacc accaaacgaa 2653321 ttagagatca ggaaaaggcc actgcgctgc agactgctga aatggtagct gaagcgccga 2653381 tgacagccgc tgctttagaa agcggaaaaa aacaaaagga actgcagagc tacacaaagc 2653441 gggttcagaa aattaccggc acggaatttg ttgtcgtcat ggatatgaac ggtatccgca 2653501 aaactcatcc tgacccgagc aaaatcggaa aaaaattcag aggcggtgat gagtccgagg 2653561 tattaaaagg gcatgtccat atcagcacag cctctggcac gctcgggaaa tcgcagagag 2653621 cgttcgtccc tgtctacgcg gagaatggaa aacaggtcgg tgcagtcgcg gtcggcatca 2653681 ccgtaaatga aattgatgaa gtgatcagcc atagcttacg gccgctttac tttattattt 2653741 gcgtcagcat cttcgtcggt gtgatcggag ccgttatcgt cgcccgtaca gtgaaaaata 2653801 tcatgtacgg acttgaacct tatgaaattg cgactctgct tgaagaacgg agcgcgatgc 2653861 tggaatcgac gaaggaagga atactcgctg tcgatgaaca tggcaaaatt aaacttgcca 2653921 acgcggaagc aaaacgccta ttcgtcaaaa tgggcatcaa cacaaatccc attgatcagg 2653981 atgtagatga catcttgccg aaaagccgct tgaaaaaggt cattgagaca aaaaaacctc 2654041 ttcaagacag agacgtccgc attaacgggc tggagcttgt gtttaatgaa gttcctatcc 2654101 agctgaaagg acaaactgtc ggagcgattg caacattccg cgacaagacc gaggtaaaac 2654161 atttagctga acagctttcc ggtgttaaaa tgtatgcaaa cgcactgaga gcgcagtctc 2654221 atgaatttat gaacaaactg catgtgatat taggtctcgt ccagctgaaa gagtatgatg 2654281 atcttggaga ttatattaaa gatatagcca tacagcaaaa atcagaaaca agtgaaatta 2654341 taaatgatgt caaaagctcc gtactggccg gttttctgct tggaaagcaa agctttatac 2654401 gtgagcaggg cgcaaatctt gatattgaat gcaacggtgt catcccgaac gcggcagacc 2654461 cttctgtcat ccatgaactt attacaatca tcggaaatct catcaacaat ggcttagatg 2654521 ccgttgccga tatgccgaaa aaacaaatca ccatgtccat gcgcttccat aacagcatac 2654581 ttgatattga aattaccgat actggagcag gcatgtctga agaagaccaa gccaaagtat 2654641 ttgaacaagg ctattcaaca aagggcaaaa accggggatt cggcctttat ttcacacagc 2654701 aaagcatcga aaatttaaaa ggccaaatga tcctcacaag cgaaaagaat gaaggaacga 2654761 cattcagtat tcgcatcccg tacgaaccga aggaggaaaa tcatgattaa tgtactaata 2654821 gttgaagatg accccatggt gggtgaatta aataaacgat acttaagcca aatagatggc 2654881 tttcagctga aaggcatcgc ttcttccttt caaagcgctc tgcatatttt aggggagcac 2654941 catattgacc tcattttgct tgatatttat atgccgggaa aaaacgggct ggaactgctg 2655001 acggaattga gagcccaaaa tgaagcggtt gacgtgattg tcatctcagc ggccagcgag 2655061 cttgacgtga tcaagaaaac acttcggtac ggagctgttg attatttaat caaaccgttt 2655121 gaatttgaac gattccaaac ggctctgtct gattacagac gaaaacaaaa ggtgtattca 2655181 acccatcgca acatgagcca aaaagaactg gacgccgagc tttttcaaaa gaaagaagca 2655241 acagaaaaag tgcagcttcc taaaggcctg acaaaaagca cgctgaagct gatctggtcc 2655301 agtatccagt catttgaaaa tgaatctttt acgacagaag acttggcaaa gcacacagaa 2655361 atctctcaag tatccatacg aaaatactta aagtttcttg aagatataca ggttctgaat 2655421 gtagaaatgg cgtacggaac gatcggaaga cctgtgtttc agtacaacgt caacaacagt 2655481 aacattaacg gaataaagca atatctataa gaaaacgcac tgcttgcttt gagcagtgcg 2655541 tttttctgtc atatctcttg ccaagatgct tgattctatt gttgataagt tatacaagaa 2655601 taacaaaggg ctttcacatt tttaagcaaa taattctaaa aatagataat ttttaaaaaa 2655661 ttatgcgaaa ttctatttat ttcttattag ttaaatgata aattatgatt ggttagttga 2655721 tcccgaaaaa ctaagtcata agtcttactt cagaaaacga tgtcacggtt ttccgcccgg 2655781 aacgccttcc gcatccttct cttccccgcc tttcgaagga aatactcaca ccacgcttat 2655841 tcagggaaga atagaactgt ctcagcgcat tccatttgtt attatcagaa aattttatcg 2655901 attctaagaa attgttcagg acagcccatc acatgactgg ccggatcagc tttgaaccaa 2655961 atttttctgg ggggttatat cttgaataaa cgaaaaatcg gattggcgat gtcacttgtg 2656021 atcgcagcag gcaccatatt aggagcatgc ggaaacagcg aaaaaagcag cggctcaggc 2656081 gaaggcaaaa acaaattcag tgtggcgatg gttactgacg taggcggagt ggatgacaaa 2656141 tccttcaacc aatcagcctg ggaaggcatc caagcctttg ggaaagagaa tgggctgaaa 2656201 aaaggcaaaa acggttacga ctatcttcaa tccaaatctg atgcagacta tacaacgaac 2656261 ttaaataaat tggcgcgtga gaattttgac ttaatttacg gcgtcggcta cttaatggag 2656321 gattcaatca gcgaaattgc tgaccagcgt aaaaatacaa actttgcgat tatagatgct 2656381 gttgtcgata aagacaacgt cgcaagtatt acgtttaaag agcaggaagg ctcatttctc 2656441 gtcggagtgg ccgcagccct atcaagcaaa tcaggaaaaa tcggctttgt aggcggcatg 2656501 gaatcagagt tgatcaaaaa attcgaggtc ggcttccgtg ccggcgtgca agcagttaac 2656561 cctaaagccg ttgtagaagt gaaatacgca gggggtttcg ataaagccga tgtcggtaaa 2656621 gcaaccgccg aaagcatgta taaatcaggc gtagatgtta tttatcactc tgcgggcgcc 2656681 actggcacag gcgtctttac tgaagcgaaa aacctgaaaa aagaagatcc aaaacgcgat 2656741 gtctgggtca tcggtgtcga taaagaccaa tacgcagaag gccaggtaga aggaacagat 2656801 gataacgtca ccctcacttc catggtgaaa aaagtagata cagtcgttga agatgtaacg 2656861 aaaaaagcga gtgacggaaa gttcccgggc ggcgaaacac ttacctacgg gcttgatcaa 2656921 gacggagtcg gcatttctcc atctaaacaa aatctatcgg atgatgtgat caaagcggtc 2656981 gataaatgga agaaaaaaat catcgacgga ttggaaatcc cggcaactga gaaagagctg 2657041 aaaaccttca aagctgaata agaatcgcag ggataaggag gtcgagccct tatcccttgt 2657101 ttttctttta ttttgaaata aaggagcggt caatcaatgg aatatgtcat tgaaatgctc 2657161 aatatccgca aggcgtttcc aggtatcgtc gccaatgaca atatcaatct tcaagtcaaa 2657221 aaaggcgaaa tacacgcgtt gctcggtgaa aacggagcgg ggaaatcaac attgatgaat 2657281 gtccttttcg ggctgtatca gccggagcgg ggtgaaattc gggtgcgcgg cgagaaggtg 2657341 cacatcaaca gcccgaacaa agcgaatgac cttggaattg gaatggtgca ccagcacttt 2657401 atgcttgttg acacctttac agttgctgaa aatattattc tcgggaagga gccaaagaag 2657461 tttggcagaa ttgaccggaa gcgtgctggc caagaggtgc aggacatttc cgatcgatac 2657521 ggcctgcaga tccatcctga agcaaaagca gctgacatat cagtcggtat gcagcagcgc 2657581 gcagaaatat taaaaaccct ctaccgcggt gccgacattc tgatttttga tgaaccgacg 2657641 gctgttttga cgcctcatga aattaaggaa ctgatgcaaa ttatgaagaa cctggtcaaa 2657701 gaagggaagt ccatcatctt aatcacccat aagctgaaag agattatgga gatttgtgac 2657761 cgcgttacgg ttatccgtaa aggaaaaggc atcaaaaccc ttgatgtccg tgatacaaac 2657821 caagacgaac tcgccagtct aatggtcggc cgtgaggtat cgttcaaaac tgaaaagaga 2657881 gctgctcagc cgggagcgga agtgcttgcg attgacggca taactgtaaa ggatacccgc 2657941 ggaatagaga cagtcagaga tttgtctctt tctgtcaaag cgggagaaat agtcggcata 2658001 gcaggcgtcg acggaaacgg gcaatctgag ctgatcgaag cggtgacagg actccgcaaa 2658061 acagattcag gaacaatcac cttaaacgga aaacagatcc aaaacctgac gccaagaaaa 2658121 atcactgaat ccgggatcgg gcatattcct caggatcgcc ataaacacgg tctcgtcctt 2658181 gattttccaa tcggagagaa tatcctgctg caaagctatt acaaaaagcc gtattcagca 2658241 ttgggcgttt tacataaagg cgaaatgtac aaaaaagcac gcagcctgat cactgagtac 2658301 gatgtcagaa cgccggatga atatacacac gctcgggcat tgtcaggcgg aaaccagcaa 2658361 aaagcgatta tcgggcggga aatagaccga aatcctgatt tattaattgc cgcccagccg 2658421 actcgcggcc ttgatgtcgg agcgattgaa tttgtccata aaaagctcat tgagcagcgt 2658481 gatgccggga aagccgttct tctcctctcg tttgagcttg aagaaattat gaatctcagt 2658541 gacagaatcg ccgttatttt tgaaggacgc attatcgcca gcgttaatcc gcaggaaacc 2658601 actgaacagg agcttggtct cttgatggca ggaagcacgc aaaaggaagc ggggaaagca 2658661 aatggttaaa cgactctctc atttactcgt gccgctcatc gcaatcatac ttggtcttgc 2658721 ggccggcgcg ttgattatgc ttgtgagcgg ctacagtgtg gctagcggat attcggcttt 2658781 gtggaatggg atattcggag aaatctatta tgtcggagaa acaatccggc aaattacgcc 2658841 ttatatttta tccggattgg ctgtcgcctt tgcattccga accggactct ttaatatcgg 2658901 cgtcgaggga cagctgctcg tcggctggac agcagcggtt tgggtcggta cggcgtttga 2658961 cggaccggca tatattcact tgccgctcgc attgattaca gcggcagctg caggaggatt 2659021 atgggggttt attcccggca ttttgaaagc gcgattttac gttcatgaag tcattgtcac 2659081 cattatgatg aattatatcg cgctgcacat gaccaattac atcatttcaa acgtcttgac 2659141 agatcatcag gacaagacgg ggaaaattca cgaatccgcc tccctccgct ctccttttct 2659201 tgaacagatc accgattact cacggctgca tttgggaatc atcgttgccc ttctcgcagc 2659261 agttatcatg tggtttatca tcaacaaatc tacaaaagga tttgagctcc gggcggtcgg 2659321 gtttaaccag cacgcttccc agtatgccgg catgagcgtg cggaagaata tcatgacctc 2659381 catgcttatc tccggcgctt ttgcaggtct tgccggagcc atggagggcc tagggacatt 2659441 cgaatacgca gcagtgaaag gcgcatttac cggcgtaggc tttgacggta tcgctgtcgc 2659501 tcttctcggg ggaaacacag ccgtaggcgt tgtactggca gcatgcctgc ttggcgggct 2659561 gaaaatcggc gcattaaata tgccgattga atcaggcgtt ccatcagagg tcgttgatat 2659621 tgtgattgcc attattattc tatttgtggc ttcaagctat gcgattcgtt tcgtcatggg 2659681 caaattgaag aaaaaggggg cgaactaagt ggacattgtg cagattttat ctatcattgt 2659741 ccctgccaca ctcgtctatg cggccccgct tattttaact gctctcggcg gcgtgttttc 2659801 cgagagatca ggtgtggtga atatcggcct agaaggcctc atgattatcg gggcgttcac 2659861 cagcgtgtta tttaatttat tttttggtca ggaattaggt gccgccgcac cttggctttc 2659921 gctccttgcc gccatggcag caggcgccct gttttcactg attcacgcgg cagcggcgat 2659981 ttcgtttcgc gccgaccaga cagtcagcgg tgtcgccatt aacatgctgg cgcttggggc 2660041 aactttattt atcgtcaaac tgatctacgg caaagcgcag acagacaaaa ttccagagcc 2660101 tttttataag acgaaaatcc ccggtttggg cgatattccc gtcttgggaa agatcttctt 2660161 ttcggatgtc tattatacgt ctattcttgc aatagcactt gcctttattt cctggtttat 2660221 cttgttcaaa acgccgttcg gccttcgtat ccgttctgtc ggcgagcatc cgatggcggc 2660281 cgatacgatg ggaatcaacg tatataaaat gcgctacatc ggcgtgatga tcagcggatt 2660341 gttcggcggt ctcggcggcg gcgtatatgc ctccacaatt gcgcttgatt tcacgcactc 2660401 taccatctcc gggcaaggtt ttatcgccct ggcagcgctt gtattcggaa aatggcatcc 2660461 gatcggagca ctgggggccg ccctgttttt cggattcgcc caaagcttaa gcatcattgg 2660521 atcgctgctc cctcttttta aagacatacc aaatgtgtat atgctgatgg ctccttatat 2660581 cttaacgatt ctcgctttaa ccggctttat cgggcgggca gatgcgccaa aagccaatgg 2660641 cgtgccttat attaaaggaa aaagataaac attctcccct gggaagacga ttctcaggga 2660701 tttttttcta atccaaaaga cccccttaat ttaattgttt attagttttt taacttaaaa 2660761 aaatatgaag tgttaacgct ttcttgtaga ctgtaacaaa caatacatgg gggtgtatga 2660821 catgggagca attccaaaaa cggggacaat ttcacctgag caaaaagact cacaggagaa 2660881 aaacctgttt caaaaaattt ggtcttggga aatcggtgtg attcctttgc cattatacac 2660941 agtattagct gttattatta ttcttgcagc atattacaat gagctgccgg caaatatgct 2661001 tggcgggttt gccatcatta tgattcttgg tgtgtttctc ggagacatag gccaacgcat 2661061 accgatattg aaggatattg gcggccctgc tattttatct ttgtttgttc cttcattttt 2661121 agtcttttac aatgtactga attcaacatc tttagacgct gtaaccaact tgatgaaaac 2661181 gtctaacttc ctttatttct atatcgcttg ccttgttgtg ggaagtatcc tcggtatgaa 2661241 cagaattgtt ttaatacagg ggtttatcag aatgttcgtt ccactggttg caggaacgat 2661301 cgcggccgtt gcagccggca tccttgtcgg atttattttt ggctatagtg cctatgattc 2661361 ctttttcttt gttgttgtcc cgattattgc cgggggaata ggtgaaggga ttttgccgct 2661421 ttcaatcgcc tattcacaaa tactgggctc atccgccgat gtatttgtgt ctcagctggt 2661481 gccagccgca attataggaa acgtttttgc tatcatatgt gcagccttaa tgaaaaagct 2661541 tggcgacaag cgtccagatc taaatgggaa cggacgtctc gtaaaatcta aaaaagcaaa 2661601 tgagattttc aatcaaaaag aagccgaagc aaaaattgat tttaaactaa tgggagcagg 2661661 agttctgctc gcgtgtacat tctttatttt tggcgggtta ttggagaaat tcatcttcat 2661721 cccgggcgcg atcttaatga ttatttcagc tgcggctgtc aagtatgcaa atattcttcc 2661781 gaaaaaaatg gaagaaggcg cttaccagct ttataagttt atttcttcaa gctttacatg 2661841 gccgctgatg gtcggtctcg gcatcctctt tattccgttg gatgacgtag cgtctgtgat 2661901 ttctataccg tttgtcatca tctgtatttc agttgttatc gcgatgattg gttctggata 2661961 tttcgtaggc aagctgatga acatgtatcc ggttgaatcc gcaatcgtta cctgctgcca 2662021 cagcggtctc ggcggaacgg gtgatgttgc cattttatcg gcatcaggaa gaatgggcct 2662081 tatgccgttt gcccaaattt caacccgtct cggcggtgca ggcacagtta tttgcgcgac 2662141 agtgctgctt cgttttttca cttcataaac agaaagagtt ccgttttatg cggaactctt 2662201 tttttattta ttcacaatcc gaatatactc tcggggacca aacggcagat cctttgattc 2662261 cgtctcactc attctggctg acaggtggtg ctccagtaaa tacagctccc actcatcaca 2662321 agccgccaca ccgctgcgcc cgtcatattg attcaacatg aatgcccctg caaatactga 2662381 gcagaataaa cctgagcaca tcacgacttt tgttttcaca tgaccagctc ctttccttca 2662441 gcttgatcag gattgatttt aaatatacaa ataacctctt ttttgttaga cttattttga 2662501 ggtcaaaaga actcataaaa atccattaca gcagttcgaa gcgtggcagc ttgcagaaaa 2662561 gtgcgatata atttggacta ggtcgtttga ccgtatattt tatacatagc gcatttttca 2662621 attgagaacg agaaaaggag gtcttatctt tgcagctctt acatcttgct attttatcgc 2662681 cttttttatt tgcttttatc attcccttct tggcaaaata cgcaaaaaga gtgcatacgg 2662741 gctggtttgt gttgatcctg cccgtcttgc tgtttatata ctttctccca atgatcagga 2662801 tgacgcaatc tggagaaaca cttcgatcgg tattagagtg gattccgtca ctcggcatta 2662861 actttaccgt ttatatagac ggcctcgggt tattattcgc tttactgatc acaggcattg 2662921 gctctttggt cactctttac agcatttttt atttatcgaa agaaaaagaa cagcttgggc 2662981 ccttttatgt ctacttattg atgttcatgg gcgccatgct cggcgtcgtt ctagtagaca 2663041 atgtcatggt tctctacatg ttctgggagc ttacaagcct ttcatccttt ttgctgatcg 2663101 gctattggta taagcgggaa aagtcgcgct atggcgcagc caaatcactt ttgattacgg 2663161 tcagcggcgg gctgtgcatg ctcggcggat ttattctcct ttatttgata acggattcct 2663221 tcagtattcg agagatggtt caccaggttc aattaattgc cggccacgaa ttgtttatcc 2663281 cggctatgat tctcatttta ttaggggctt ttacgaaatc ggcgcaattt cctttttaca 2663341 tctggctccc tgacgcgatg gaagctccga cgcctgtcag cgcttatctc cattcagcta 2663401 ctatggtaaa agccggcatt tatgtgattg cgagattcag tcctattttc gccttttcag 2663461 ctcagtggtt ttggatcgtg tccctcgtcg gcctctttac gatggtttgg ggttcattcc 2663521 atgccgtgaa acaaactgat ttaaaatcga ttttggcgtt ttcaaccgtc agccagctcg 2663581 gcatgatcat ctccatgctc ggagtcagtg ctgcggccct tcattacgga catacagaat 2663641 attatacagt tgccgctatg gctgccattt tccatttgat caaccacgca acctttaaag 2663701 gaagcttgtt tatggcagtc gggattatcg atcacgaaac aggcacacgg gatatccgga 2663761 agctaggcgg cctgatggcg attatgccga ttacttttac catttcctta atcgggacat 2663821 tttcaatggc cggcctaccg ccgtttaacg gatttttgag taaagaaatg tttttcacaa 2663881 gcatgcttcg cgtgacacat tttgacctgt tcaacgtgca gacatggggc gttctgttcc 2663941 ctcttttcgc ctggatcgga agtgtattta cgtttatcta cagcatgaaa ttgctgttta 2664001 aaacattcag aggaaattac cagcctgaac agcttgaaaa acaggctcac gaagcgcctg 2664061 tcggtatgct cgttccaccg gtcattcttg tcgctttggc tgtcagtctc ttctttttcc 2664121 cgaatatatt gtcgtacagc ctgatagagc ctgcgatgaa ctcaatctat ccgacactgc 2664181 ttgacggcca tgagaaattc cacgttcaca tttcacagtg gcatggggtt acaacggaat 2664241 tgctcatgac tgcgggtatt gttgtgatcg gaacaattgg ttatttgtcg ctgaataagt 2664301 ggaaaggaat ctataaactg tttccttcga aactcacact caaccggtta tacgataagc 2664361 ttttgactat gatggagaaa ggctcttacc gggtcacaaa acaatatatg accgggtttt 2664421 taagagatta tttgctgtat atcttcgctg gtttcatcat tctgataggc ggagcttttg 2664481 ccattaaagg cggattttca tttaaaacgg aaggcatggc taaaatcggt gtatacgaaa 2664541 tcattttgac gcttgtcatg atcagcgcca cagtggcgac tgtttttgct aggtcaagac 2664601 tgacggcgat cattgcactc ggtgttgtcg gttatacgct tgcattgttt tttgtcattt 2664661 tcagagcgcc ggacttggca ttgactcagc tcgtcattga aacgatttct gtggcactgt 2664721 ttctgctttg cttctaccat ttgccgaaac tgaggctgaa aacaaaaacg agaacgttcc 2664781 ggatgacgaa ttttatcatt tctttaggcg tcggtgttat cgttacactg ctcggcatcg 2664841 catcctcaag ccagcggaca aaagacagca ttgcgtcctt ctttgtcaaa cacagccacg 2664901 atctcggcgg aggggataat gtcgtcaatg tcattctcgt tgatttcagg ggatttgata 2664961 caatgtttga aattacggta ttaacgatag ccgctctcgg catttacagc atgattaaaa 2665021 caaaagtaaa agaggagggg aaaagcggtg aatgaacaaa aaacaaatga cttgattctt 2665081 caaaccgcga caaagcttgt atcctttatc attttgcttt tctctttcta tttattttta 2665141 tcagggcata acgcgcccgg aggaggcttt gtcggcggac tgatcacgtc ctcttccatc 2665201 gttctcttgc tcttggcata tgatttaaaa accgtgcgtt cccttttgcc tgtcaatttc 2665261 atttatgtcg cgggagccgg ccttctgctc gctgtattaa caggcgttgg ctcctttgtc 2665321 ttcggggctc cttttttaac ccacacattc ggatactttc agctgccgat ccttgggaaa 2665381 acggagctcg ccacagcgac gatatttgat ttaggcgttt atcttgttgt cgtaggcata 2665441 acgatgacca ttattcaaac gattggagag gaagaataat ggaaatctta atggctgtat 2665501 tagccggtat tatttttatg gctgctacgt atttgctgct gtctaaaagc ctgcttcgcg 2665561 tcattatcgg aacagcactg ttaagccatg gcgttcattt aatgcttttg actatgggag 2665621 gattaaagaa aggcgccgct ccgattttga gcgagcatgc caaatcattt gtcgatccgc 2665681 ttccgcaagc cctgattttg accgcaattg tcatttcttt tggcgttacg tcattcatcc 2665741 tcgtcatggc ctttcgcgct tatcaggaat tgaaatcgga cgatatggat caaatgaggg 2665801 gaaatgatca acatgaataa ttttgttatt ttgccaatcc tgatcccgct tttgtcggct 2665861 attcttctga ttttcatgac gaagaatctt atgctcatga gaatcttcag cacggcggca 2665921 tcggccatcg ggattgtgat tagcggcata cttgtacaga ctgtcttcac aaaaggcatc 2665981 cagacactca gcctaggcgg atggaaagcg ccgtacggca ttgtgcttgc cgcagaccaa 2666041 ttcgccagcc ttctcgttct cacaacagcg atcatcggtt tattggttgg gctttattcc 2666101 ttccgttctg tcggtgaaaa acgggagcgc tccttttact actccggcgt tcagttcttg 2666161 cttgccggcg tcagcggagc gtttttaaca ggcgatttat ttaatatgta cgtatttttt 2666221 gagcttctgc ttattgcttc ctatatgctg attgtattag gcggcacaaa aattcagctg 2666281 cgggaatccc ttaaatatat tgtgtttaat attgtatcgt ctgccctgtt tgtcataggg 2666341 gtcggctttt tatacgctgt aaccggtacg ttaaacatgg cggatcttag cgtgaaaatc 2666401 agcgaatcag gacaaaccgg gctgatcact gtgattggtg tcctgctgct tttggtattt 2666461 ggcatgaagg gcggaatctt ccccctctac ttttggcttc caggctctta ttacgcgcca 2666521 ccggcggcaa tctccgcgtt gttcggcgct ttgctgacaa aagtcgggtt atatgcgatt 2666581 acgagggttt tcacattgat ttttattcac gatacagcct ttacccatca gttgatgatt 2666641 tggctggcgg cgctgactgt gatttttggt gtgatcggtt cactcgctta ttcgaatgtc 2666701 atgaaaattg tgatctataa cattattacc gctgtcggcg tgattttgtt cggtgtggca 2666761 gtacacaccc ccgcatccat tcagggcgcg atctactatc tgattcacga tatgctgatt 2666821 aagggcgctt tgttcatgct ggcaggtacg ctgatcgcat tgactggaac cgcgagcctg 2666881 cataaaatgg gcgggctgat caaacgctat cctgttcttg gatggatgtt tttcatttcc 2666941 gctatttctc ttgcaggcat tccgccactg agcggatttg tcggcaaatt taaaattgca 2667001 gagggcggct tcgcagaagg tgaatttacg atatccatgc tgattctgct ttcgagtctg 2667061 cttgtactgt actctgtgct gaggatcttt atacatgcgt tttggggcga agaaaaagaa 2667121 acgccaaaac caaatcatcg aacagctaaa ggacttcttt atccggcagc tatttttctc 2667181 ttgctgtccc ttctcttcgg attgggtaca gaatgggtgt cgccttacgt tgatcaagcg 2667241 gccgagacgc tgctgaatcc ggaaaaatat atcgaagctg ttctgaagga gtagatcgca 2667301 tggcatttca aattttatta aatgtgtttc tcgctttttg ctggatgttc ttaagcaaca 2667361 gtccaagcgc cgcaggattc attacaggct atattctggg aatgctctct ctctttttct 2667421 tccggcgctt tttcactcgc cagttttatc tatggaaatt gatttctatt atcaagctct 2667481 gtttcatttt tataaaggaa ctgtaccttg ccaatgtcag tgtgatgaaa tcagtcttat 2667541 ctccaaaact gaatatcaga ccgggtattt ttgcttttaa aactgaactg acgaaggact 2667601 gggaaatcac catgctttct ctgctcatta cattaacgcc gggaaccttg gtgatggata 2667661 tttcagatga cagaacaata ctttatattc atgcaatgga tatcgaggat gcggaaaaag 2667721 cgatttttga cattcgggag tcatttgaaa aagccataca ggaggtgagc cggtgatgtt 2667781 tacgctgatc ctgcaaatcg cgctcggcat tatggcagtg tctacctttt tgtatgtcat 2667841 tcgtgtcatt aaaggtccga ctgtgcctga ccgggtcgtg gctctggatg caatcggcat 2667901 caatctgatc gcaatcacgg cgcttgtctc cattttgctg aaaacaagtg cgtttttgga 2667961 tattattttg ttgctgggga ttttatcgtt tatcggaacg atcgcatttt ccaagttcct 2668021 ggagaaagga gagattatcg aaaatgatcg aaaccgctaa ggtcgttgtg gctgtattca 2668081 ttttgctggg tgctcttata tgcctcattg cttcatttgg cgtacttcgc cttcccgatg 2668141 tgtttacacg cgctcatgct gcttctaaag gctcaacatt aggtgtcaat atgattctgc 2668201 tcggtgtctt cttctatttg tggtttgtga cgggggagct ctccgctaaa atcctgcttg 2668261 ggattctctt tatctttatt acgtcgccta tcggcgggca cttgatctgc cgtgctgcgt 2668321 ataactccgg cgtcaagctt gatgagagaa gtgtgcaaga tgactataac ggaatcagaa 2668381 actttgtgat taaacgaaaa gaggattctt atttataaaa ataagcagcc ggacaggcag 2668441 agttccggct gtttttttat ttcttgatga cagccagcgt gcatctggat atacagatca 2668501 gcctctcttg ctcgtcatat atgtgaatat gatagacaat cgtcgttctg cctatatgaa 2668561 cgggctcggc tatcgccttt accgttcctt cctttacaga ttttaaatgg ttggcgttaa 2668621 tctccaaacc aacacaagct tgcgttgtat gatcaatcag gttctgtgca cctgcgctcg 2668681 ccgcggtttc cgccagggcc actgaagcgc ctccatgcaa atatccgaac ggctgtaccg 2668741 tccgatgatc caccggcatg accgcaacgc atcgttccgc tgtgttttca acaatctcaa 2668801 taccaagcgc ttcaagcaat gtgtgcttca tatccatctc tacacccccc aacatttaaa 2668861 gtacaccgtc tgatttcgca atcaaaaccg cttccgtccg tgaaccgaca ttcagcttat 2668921 tgaaaatcga tgtcaagctg tattcaatgg accgcttgct taaatgaagg gcatctgcga 2668981 tttcttggtt tgtaaatccc ttttcaactt cttgaagaat caggcattct ctaggtgtga 2669041 gcacatcttg ttctttttga gaggaaggag ccggctttgt tttttgctga gtcatcagct 2669101 gtttaaagta agcaaaatcg actaaaattt ctccgttgag tacgtggtat atgtattggg 2669161 tgatcttttc tttagattcc gttttgctga tggcaccgtg cagacccgca cgaatcgctt 2669221 cctcgaaata atcctcgacc tcataaccgg tatacacgat aattttacaa tgaggattct 2669281 cttgtaaaat ctgtttagaa agctccatcc cattgacctc gccgcctaga ttcagatcca 2669341 ttaaaatgag atcatatgac gagaaatcat gctgcttgat aaactgttcg ctcggttcag 2669401 gactgagaca atcaacagac aaattcgaat ccgtttccaa aattgtcttg gtgccttcca 2669461 tgacagccgg atggtcatca atcactagta tctttttcat gttttcctcc cttttactca 2669521 ctcttttcca ttttataaaa aagacttggc ctgtgccaag tcgtttccgt tataaatcca 2669581 ttacaattcg atttcaatat cagccttaaa gccctttcct tcacttgttt caatccgaag 2669641 gcgcccatct aaagccctga ctctctcctt aatgccagaa agccccatgc tcatggaatg 2669701 ctcagtattt ttttcttgat caaacccaac gccatcgtcc tcataatgaa gaacgatttt 2669761 gttttgaata ctgatgagca taatcagcac atccgtcgcc tgagagtgct tgaccgcatt 2669821 agacagaaac tcttgaatga tccggtacaa attcagctgc gaatccagat caagggaagc 2669881 cgtaaatctc ccggtattta aacggatatg aaacggaacc cgctcctgct gctgcgccac 2669941 cagcttcgac agcgccttca ccaatccaag atcatacaga agctgcggcc gcagctcatg 2670001 acacgtctcc ctcgtcatcg aaatcacatc agacatctgc tcattcatct gtacaagctt 2670061 gtcctgcacc tcttcacggc acggattatc atccttcttg aaatcaccca aaaacagctc 2670121 acactggcgt tttaaggaaa tcaaatcctg aagaaccgaa tcgtggagat cgcgggcgag 2670181 tcctgaacgc tgtttttctt cgattgcaaa cattagcttt ttcagccaga tggggttggt 2670241 tccctcttgt tttaagtcct tcaaatgttc catgagctcc tcaatatgca ggacattttc 2670301 catggacaca cttgtataaa aagacagtgt tttcagccac gatatttcat cacgtgttag 2670361 ccggggagtg ttaatattag ataaacaaag cagaacataa gaactaccgc ctcgttcacc 2670421 aactttcata agaaagcctt gattgacttc tataattttc ccaatttctg aagttacgtt 2670481 ttcaaattcc tcttgataaa aattccagtc cggtccaact tcatgcttat ctaaaaatat 2670541 cactttgtga tcaggagtaa cctcaaaggt ataagctttg cttacaagca aaacatccag 2670601 tatagtattt ttcagttctt taaaaacttg ttgaagagaa gttacacccc tcattagctg 2670661 agtatattta aaaatactgt cctgatagtt gaatttttcg gagaaacgtt ttaaccgaaa 2670721 tttaaaatcc atgacctctt taaaataaaa gacagcgaac atgacaacga aaaaaaatac 2670781 agtttgacgc acagggttca tctggatgtc cattacatca aacagaacta atgcaccaac 2670841 tattagaaga gttggtatca tggcaagtag agcatagtat ctcattcttc ctaagataaa 2670901 ctctatatca aacatcttat tggctacaaa ttggtatact aacccgaacg gaattagtac 2670961 tagtaatgac gccgaagcta atgccgggaa aatataatta cctgtaaata ttattggaag 2671021 aacaaaaaat atcaaaaaag gcgcaaatga aagagtgttt gttaaaatta gtaatttaag 2671081 aataaacgaa tgctcagcat atttatattt attaagatgt aagtatatcg ctgaaaaaga 2671141 aaatagagtc aaagttgcaa aagaaaccaa attaagagtt gctaaaaaat caatatctac 2671201 ttgtaaatag tcttgaaaaa actcaatacc aagattaaat attggtatga tataaagaaa 2671261 agaaattcta ttcaaaaaag ttttacctat ttctccaagg tatctttgta taaattgaag 2671321 ataaagaata ggagaagata taaaagtaaa caagttaata taccgattga ttatatgtcc 2671381 tctaaatggt ccgcctgcac ttatatatgc tatcgaaatg tctaataaca atagaataag 2671441 aatataggca gcaaatgatc tccttttttt atttacttta agtatataaa aaatacatat 2671501 tatgcttaaa aaataaaaaa acaaaggaag tacgaacaga aaaaaactat aaggtctatt 2671561 tagagtaact aaatcaaaat ctttgagatg aatctttttt ccacttctca aaatatccag 2671621 actgttaata tgactcaaat atccccattt caaatgtttg tctgaaggtt tttctttatt 2671681 aatttttaat atgatgtctc cctgtctcag accaacaaat tgtccatatg aagattccga 2671741 tatttcttct atcataaatt gacttttatc atttttatga atcttagtcc caataataat 2671801 tccattcata ctgatataag ttgtatagct tatataaagg atactcaaaa caattacagc 2671861 tattgtgaat ttttttatta agttcttcaa tattaatcca cctattaatc accccattga 2671921 cgggttattg gatcagccag ataataatca ttataagctt taattattgt ttcagtttct 2671981 tgcacatcaa aacctataag gcaggcttct ttatttttca atttttttaa agcctcagga 2672041 taatttaaaa agtagttaat taggtcttgc atcttgtatc cccctttgta taacttaata 2672101 agcattcctt tattagctct ttttttcttt atctaaattt aattgttcta tagcagaaat 2672161 acatttctgt ttatatattt ccaataatac cgaaatgtat tgagtaactc ccgctttaat 2672221 taatttttct tggaatttct ctttatcaag taacgattta taatataagt ctttatgtga 2672281 aattaagtat aataaatctt ccgaagcatc attaaaaagg cgcttaagat ataagtaaat 2672341 cagtgtatgt ttgttttttt caatatcact gcgatttccg gataaaagaa cataataatc 2672401 tccagaaatt tgagctataa tccctttata gtaggaatat ctttcaactg tttcattata 2672461 ttctcctgta gccaataaaa cacctgctac atttgctagt gcaatcagac ttccacattt 2672521 taatctaatt acttctaaac tttcatcttc tgttttagat ttattagtga tatcgtcatg 2672581 ttgaccttgc atggcctcgt ttacgtattt taaaacatat ttaaaaatta gaggattgtt 2672641 atttaatgaa taaatactcg ttaatcctac tgtatacaag gaaagtgctg catttaacga 2672701 ctccgagcga ttaattttca tccataatgc atggtgatta tcttcatctt caagatcatc 2672761 cataatatct gatgaaagaa taagaatttc tattcccgcg ccaagccttg ttgcaacatc 2672821 taaattctcc cctccaaaaa caacataatg taagattgtg gattcagcaa aggagaatgt 2672881 ttctttagaa tcaataaatg agtaaagaag ttgtgacaaa tcctcgttaa atatgttttg 2672941 ctccacaatc tccttcattt tctccttgat ccggacagaa tctaaacata tctgctcaat 2673001 aacgacttcc cccctcccat tccattttac taaatgggac atttaaagga cagcaggttt 2673061 ttcgtttttt aacaatcata taatacttta tccatttatt gtatcggtag aacgaaaaaa 2673121 aagacttgtt tccaagtctt tttcacgaaa ttttcattgc ataattgtat ttatcgagtt 2673181 gatcaatgct tttgttaatg tttcgtaatg aatctgtcgt ttctttaata tcaagttcga 2673241 gtcggaataa caattgtttt acttcttcaa gtttcttttc catcgtttcc acactccttt 2673301 ttttgaaaga tcaatgaatt gtgtatggtg aacgagtcct aggtatttga tctgttacta 2673361 atagtgtgtc tgctttcggc tcatttttca ccgaaaagta tgcaaaaaag tcctgcgtga 2673421 caccgcaaat ctcaataggt ccttatactc aaaggaatca caacaagaac gggactatct 2673481 ttctatgcga aagagcgttt atatgtgctg aaattgagaa agattcttaa tctccttgat 2673541 tttaacgggt ttcgcatttt cactaagcaa gactatagtc cttcataccg tattttcaaa 2673601 attgaatatg cgattcttgg cgtttcctga ccgacaaaca ccgaaaaaga ccgcaacgct 2673661 aaagttgtgg ccttttcgct ttgtcatatt cggcaattag ggatctatac atatagaaac 2673721 atcctttttt gcgaggtgct cccatgagat atcgttatcc ctggttttac gtgtatccgt 2673781 atgaggtacg ccgtccgccc gctcctgcca acaatattga tacctttatc cgttcagcga 2673841 agcaggccgc agggatattt gcggatgccc agctcgttct cagccgcatt gcgggctcgc 2673901 gggagctttc gcgccgcatt ctgaccgcag ccgaacagtc tgataaacaa actataaggc 2673961 gcctgatcaa acaaatgggc gtccggcatg aagtggatac ggtctttaat cccgacggca 2674021 tctatatcag ccttatcgga acgcaaagcc gaatgattct tgctttgcgg tggtcagagg 2674081 accgcaatca ttttgcgtcc ataagattat gacaccattc cagagcctct aaataacatt 2674141 catacgcttc ttctttgtcc agttgattgc ctaattctga gcaagtgtcc cagttgttgc 2674201 tttcaattaa tttcacaagc tcaagcattt ggtagtagtc gttttgatgg cctaataatg 2674261 cttgcccgac ttcatctttt aaaggcaatt cttgaacaat ttcctctatt tctctatgca 2674321 ggagggtgtc tatgagagaa aacattccga tcagcatata agaagcaggc tgcggccggg 2674381 atgtctttct cgccagcagt tcgcaaagct ttgctcttat cagagaaatc ttaatgattt 2674441 cgtgcttgct ggaatgccct ttcctgctta aatccttaaa ggaaagaata tatatccacc 2674501 gtttgatttc attaaatccc agcagcataa tggcctgttg aatgctttca attttctggc 2674561 tcaaacggct gtgggatgag tttaaaaatt ttaaaatttg ataggacagt gataaatccc 2674621 gctctatgta ctctgtcaca cgctttatgt taggctgctc tttactcagt tcgttaagca 2674681 gttcatagta agaatagaaa tgagtcgata ggtcatgccc gctgatgatg cgcggctcgc 2674741 tgaaaaagta gccttggaat aattgaaagc cgtcttggac cgcctgttta tattcttttc 2674801 gggtctctac tttttccgct aaaaaaatca ggccgcggca gccgtaggtt tgcaaaattg 2674861 ttctgcgttc cattcgtgtt gttttgagaa aatcaatttt caatatatca atatagctca 2674921 tgagtttttc cagtaagtcc tcatcttgcg gatttattgc ataaaaatca tcaagcgcca 2674981 gcatataccc catttttttc aattctttgc atctagaaat gagggccggc gtgatcggta 2675041 tatcttcaag gatttcaatg acaagctgtt tcggattgaa ggaggtggga agattcgaaa 2675101 acatcaggct ttccgtaaaa ttaacaaaac agcgtttccc ttccgtcagc ttctcaattc 2675161 cgatgtttaa aaagctgttg atcaccaaat ctgttgttgc ctgatcgccg tctttagcgc 2675221 tatacacgtt ctcttcgctt tctctataca gcagttcata agcaacaacc tgttcttttc 2675281 tattaaaaat aggctgtctt gcaacaaaca ccctcattga tttatccccc ttacaatacg 2675341 cgcggctttc acccctaagt atatcaaata atttgacgaa aattgtctaa acatgaaaaa 2675401 taatatatac ataaagaaaa ctggcccttc gcgaatgaaa ggccagtttt tctttattct 2675461 tcctcaagct cttcttcaat tctgcttttc acttcgtgga tccgctgcat tttattgctc 2675521 cagcagtcct cgcttaaatc aaccgggtat tcctccggct tgctgattct cttatattcc 2675581 tcccaaagca ggctgaggtt atcctgcaca tactgctgta tgtctgaaat ctcagggttt 2675641 tggtagcaaa gaataccctt ctcaaaaatc agttcatgaa gatccttcgc ataaaaattc 2675701 gtgacaaatt tgctgatgaa tgtatgaacc gggtggaaca ttctgagccg cttctgatca 2675761 ttcacctgct catcataaag cgcaatatag tcgccttcag aatgatggtt ggactgatta 2675821 ataatgcggt agactttctt tctgcccggt gtcgtcactt tttcaggatt ggacgaaatt 2675881 ttgatcgtgt cgaccatttt cccgtcttct tcaatggcaa cgagtttata aactgcgccg 2675941 agagccggct ggtcataggc agtgatcagc ttcgtaccga caccccagac atcaatgcgc 2676001 gctccctgag cctttaaatt cataatggtg tgctcatcca aatcgcttga agcaatcacc 2676061 ttcgcatctg taaatcctgc ttcatcaagc attttccggg ctttttttga caggtacgcc 2676121 aaatcgccgc tgtccagacg gatgccaatg aaattaatgc ggtcgccgaa ttccttggca 2676181 accctaatcg cgttcggcat gcctgaacga agcgtgtcat acgtgtcaac taagaagacg 2676241 caatccttat gtgtttccgc gtattttttg aaagctgtat attcatcgcg gtaagcctgc 2676301 acaagcgcat gcgcatgtgt gccggaaacc gggatattaa agcgctttcc ggctcttaca 2676361 ttgcttgtcg cgctaaagcc gccgattaag gctgctctcg ctccccacat ggccgcatcc 2676421 atttcgtgcg cccgtcttgt tccgaattca agcgcaactt catcaccgat gacgccttta 2676481 atccgggcag cctttgttgc gattaatgtt tgatagttca caatgttgag caaagctgtt 2676541 tcaatcagct gcgcttctac caggggtgcc tccaccctca taatcggctc attgttaaaa 2676601 acgagttctc cttctttcat ggagtaaagt gaacctgtaa aagataagcc gcgcaaatat 2676661 tcaataaaat cttcatgata cccgagttca tcctgtaaat aactcaaatc gctatccgta 2676721 aacttgaaat tttccaagta ttcaatggct ttttccaagc ccgcaaatac ggcatagcca 2676781 ttttcaaacg gaagccttct gaaaaacagc tcaaaaatcg ctttcttttc atgaatgccg 2676841 tctctccagt acgtttccgc catattgatc tgataaaggt ctgtatgtaa tgacaggctg 2676901 tcatctttaa atccgtactc taacactgtt tttccccttc cttactctgc cacttgcgct 2676961 ccgatgctgt ttgcaaaatg ggaaagagcc catgcgtgcc cctcctgatt aaagctggca 2677021 acagcttgtt tatgcacaac aatccgaaaa cctttgttgt atgcgtcaac agctgtatgc 2677081 aacacacaaa tatctgtgca gacaccggca agatgcagtt cgccaatctg ccgctctctg 2677141 agtttgagct ctaaatcagt tcccgcaaaa gcagaatatc tcgttttttc catgtagtaa 2677201 acattaggtt catgttcatg tttctgatat agaggcaaaa gctttccgta cagatctttt 2677261 ccttccgtgc cttttatatt atgcggagga aaaagacggg tttcagggtg atattgatcc 2677321 ccttcatcat gagaatctac tgctaatacg acgtaatcac cgtttgtgat gaattcttta 2677381 gttaaattga cgatcgcctc ttcaatcatt ctgccgggct ccccgcaggt caattttccg 2677441 tcactcgcca caaaatcatt cgtataatca atacaaataa gtgctttttt catagccggc 2677501 ctccccgcca tcagtatgag aacattatat cttatctcca gttgtaagtg aattgccatg 2677561 aacaaaaaga caaacggtcc gtttgtctct tacgatttca gtactgaccg attataaatg 2677621 tcgtcctgaa tatatatcaa ttcacgattc acagcgatat cagccgcaat gacgatgcct 2677681 aagggcgtat gaaactggag atcagataca atcttgaaag gcactccgta ccggctcgcc 2677741 atttggatat aagaagagta agactgatac tgaagctctc cattaatcaa aagggtgacg 2677801 ttatggctgt ttttcagctc gtgctctgcc tctttatacg gtttgcttct aagcacctgt 2677861 cctttcgtca gtgccaaaac gactctttct cttaaagagc ctaaaaacaa atggcgctcg 2677921 tcaggctttg tctccaaagg cccatacatt ccttgctgca aatagagatc cattttatct 2677981 tcactcaaaa gcctgtcctc ccgtcttgtt tgtcttcatt atcacctgat caggcaggag 2678041 ctaaactttc aagcgccgtt tacatttctg ttacccaatg aatgattttt ttggccagct 2678101 caccagcagg ggtttcctct gtatgccggc gcaacgacgc ttccagccgt tcaggcagag 2678161 ttgctttatc ttcttcatag gaaatgatcg tgctccactc cagctgcggt accgctacaa 2678221 gcgtgcgcag ttcttttctg ttttcatgca gatacacgtc cgtgatcatt ccggtttgcg 2678281 tattgatatt tgcttttctg attttcataa catgacctct ctattcaaag actacccata 2678341 ttatacaata aaaaagcaac agcctcttgt gaaaaggctg ttacccgtta aacgaaactg 2678401 tttcatcagt gatatcggca tctttgaaga gagttttact cgtttggttg ttaatcttca 2678461 caaaatcacc aagctgaaat gtgcctgacc ccgcccctga atgagcgacg cttttgggcg 2678521 aaatcgcaaa tacgtctcca aagcttgccg cggcattatc cgtaactgac atgatataaa 2678581 tcggccccac aattgcaggc atttccccac ctccgcattg atttacagca tcatatgcaa 2678641 ggagccgata atggtgcccg cctattcagc tggctttgcg ttttcctcga gtcgtgaccg 2678701 ctggcgcagc ttgatcaagc ggacaatatt caggaagaac gccttcacta ccgcataaac 2678761 cggcaccgct aaaatcatgc cgagaattcc gccgaagctt cccgctccga ttaatagcaa 2678821 aataatcgta agcggatggg tattcagccg ctttccgatc acaagaggag acagcaggtt 2678881 tccgtccagc tgctgaacga tgacgaccac aataatcgca aacagcgctt tggccggcga 2678941 gtccataaaa ccgacaatga cagccggcgc ggcaccgaga aaaggcccga catagggaat 2679001 gatattggta atcgccatga caatcccaag aatcagggca tacggcagtc cggcaattaa 2679061 atagccgata aaacacgctg ttccgacaaa aagacagatt aacagctgcc cctggaaata 2679121 tgccgcaagc gtatcggata aatctttaaa aatctttaag ccttctgtcc gataagaagc 2679181 cggtagaatt tttactgcca aatgcggaaa gcggtgtccg tctttcagca tgtaaaaaag 2679241 gataaatgga acagtaataa taacaagcgt gatgtttgtc acgacaccaa acaccgcaga 2679301 taaactggac gtgatatttt gcggcaggtt ttggagaaaa cttgtcaatg actgttcaat 2679361 ttttgatatc gatacataat cctggttcat catccaggta aaccattgag aatgggacaa 2679421 atcctttgtc agcgcctgaa tctgttttat ataatcagga aggttgttaa acagccctgt 2679481 cacctgtgcg gtgatgatag gtccgactga cgctgaaata aaggcaagca aaccgataaa 2679541 cagtaaatag atcaatagaa tggataatgt ccgcggaatt tttttctcaa gcaggcggac 2679601 gaccggatta aatatgaaat acaaaattcc cgcaattagc atcgggaaaa acaatgtcga 2679661 gataaaaaca ataaacggct gaaatacaaa tgaaactttt gttgctacaa aaataatcag 2679721 caaaacaaat aaaatctgca atgtccaaaa atggactttt gatttcaaca agctttgttc 2679781 ctcctagttt ttctttgtct gtcagataaa agaacttata ccccatcatt gtaacaaaaa 2679841 tgaactcata tcagaactct taatataatg aaaggagtgt tggtgatgaa ggccgtgaca 2679901 tacgatacag attcagaact ggcttatatc tatgttcttc ctccgaaaaa gaacaggaat 2679961 gtacggactg aggagctcag agtcaatgat tgtctcctgc tggatatcag ccaagatggc 2680021 aaaatcgccg gattcgaatg ttttggtgag gcagcacacc tctgtgcccc atttgccggg 2680081 aaatcccggc tgtatgtaaa agattcagac ggttatcatt ttcgggtctg ccagcatgct 2680141 tcagtccgtt cctgctatac ggtgtaccgt gtcactttct gtttttcaga tggtgactat 2680201 caggaatttg ccggctttga ccttgatgga acaatgtatc atagtgcgtt tttacagcgc 2680261 ttaactgaaa aataggacgt cctgttgtac gcctattttt catgcgcaag cactgttaga 2680321 cccgctcact gtaatctggg gtgacggaaa tcatgtgctg gattctgatc aaacaaacag 2680381 aatttcgggc tccttcaatt gtgatatggt caggttttac atcgatcagt ctgcctctga 2680441 ccgtatctcg tactgtctgt ataacgaacc ttgagccgat gagcttttta atggtctgat 2680501 agacataagg atcgactaaa gagaccagtt gcggactacc ttggttgacc atacttttat 2680561 cccctttgtg tgttttatct cagcttatgc cgcgcttatg gataatgaca caggcttacc 2680621 tgataaaaca aaggggtgcg gagattttag gagaatacgt ttggaggcgg gtgtaaagga 2680681 agtatcgatg aagcggagac agcgaagaaa gctggcgctg ttccgtactt atacaggctt 2680741 tatcacggat gcctgggctt ggtcgattaa ttggtccagc ttttctattt tttttcgtgc 2680801 ggttgaagga tcaatttggc ggtaatgatg gtggccgccc ggctcttcat ccagttcgtc 2680861 cgcttttttg acaatctgct gcagtgtgtt tttatctaat tcgccttcag gcaaatagga 2680921 atctgtatga agcaaaatgg ctagtgcaat ctcttttgct gctttcggtt cctcgccaag 2680981 ccgaatcaga agtttatgcg cccgttccgc ccctttaatg gcatgaatgt catttctttt 2681041 gtatttctca taatcccact ttccgtctgt ataccattca taatggccaa tgtcatgaag 2681101 cagtgccgct tttgctgcta aatcaggatt aatgtcagcc ttcacagaca gcctgtatgc 2681161 atgataagcg caggcaatcg catgtgccac gccggaacgc tgaagatatt tttgtgcaat 2681221 tggatgggtg aaaacatcca ttaatgtaac ctttctcatg gaaacccctc ctttagatat 2681281 ttttagaatc ctaacataat ttgcagagaa actcaattct tatgtcacat cattttgatc 2681341 ttcttatcat cattgttata ccctaaaagc aacgtttcag tcagtatatg cggctgttca 2681401 ataaaatgcg ctggctgcag ccttttgtat aaaaaaaaga gcagaaaata tctgctctac 2681461 aaaaactctt taatatcata aatgcggccg ttttccgtcc ctttttctag taaagaaagc 2681521 agcgtgccgg caataaagtc cggactgcga aggcttcctg tttcatttaa tttccggaat 2681581 cgttcaatgt ggtggaaatc ctttttcgat gaagaacgga tgacggcctg catctcagtg 2681641 tccatcactc caggtgagaa cgaaatcatg ttcaccggca gctcttcatc ctcctgttca 2681701 aatccgaatg tcctcgtaaa catgtcgagc ccggcttttg aactgcaata cgcgctccat 2681761 cccttatatg gatttttggc ggctcctgaa gtaatgttga caaccgtctt tttgccgctg 2681821 tatgaagcaa accgttttgt aaacagctga ctcaaaagca cgggcgcagt caggttcagc 2681881 tgataatggc gctgaagctc gtcaagagac gcttcgccgg cacgtttgat cggcgttacc 2681941 attccggcgt tattaataag ggtaatacca gaataacgat ctgaatcgat ggatgagagc 2682001 aatgtttcaa attgctgttc agcttcttcg agattgatga ggtctatttg atgctgcgtt 2682061 agttttttgt gagagacatc tgttttcgtt ctggataagg catggacttc atgccccttt 2682121 tctaaagcct gtaatgcaat ggcttgaccc agcccttttg acgctccggt gatgatataa 2682181 agttccattg gaaacctcct tttccgttat tattgtacgg cacctctttt acacaacaca 2682241 agcacgcggc ctacgccttc ttgttttcct gcgctgtgac ttttgggatg aggaacacga 2682301 tgcctgcaat tccgagcagg atcagtacga catagatcat cggcagcagc aatgatgatg 2682361 tttcttgttc atcttctgtt tccgttgatg atgtctttgt cattggtttt tcagcaaaag 2682421 taattccaag ctgtttcgac tgggccgcaa tcgtgttgga atcctcggca tttgttgatg 2682481 taaacaaatc ttttatcagc tcggcgtcct tgtccttcgg tttatcaaaa gtgatatcct 2682541 tttgttcctc aggcagttct gttttttctt catagtaggt atcttcatgc aaataattcg 2682601 tatcgatttc gatgtctttt ttctcatact ggtttggcgc gacatctgta ttttcttcag 2682661 tttgggcagc cgctgcagag ggtatgaaaa gggaaaagga gagcatacaa atcatgatcc 2682721 ccttttccat gctgcgatca cgcttcatac gtttcatcgc tttctgctgt gtgttcagcc 2682781 atcaaccgga taatcagcgg cagagccacg gcaatcaccg taatgatcag cagaactgtt 2682841 attcccattg taaacaagtg cccagtaccg tactggatgt cgatatatac tttcgaaacc 2682901 ggatcttcaa atgtaaagtt cggcatgatc aaatcaataa gcggtgcgac atagaatagg 2682961 atcattgctg ctgaagcaac ccagccaggg attgatccga atctgaatgc cgtccggatg 2683021 aaggcagagc ttgcgaccag caatagaatc gtaaacaccg accacttaat cgtctgatcg 2683081 tccggcagtg aataaatatt caagccgaac aagctgatca taagtccgac aaggatattc 2683141 agaattccga ataacgctcc tttgacgaga agcggtgcgt tttggtaata cgagctgaaa 2683201 tagccgatta acagactgct gatcaacaca atgacaagga tgacaaccgg aggtaccgtc 2683261 tgaatttttt cttccggaac ctctccgctg attttaagcg gattcgctaa gtaatcatat 2683321 acatagccat tgttttgccc gtctactaat gtatttccga gtatgccgta tacgtcattt 2683381 cgcacgagtt tcgtggaggc gacatttttc ccccagttgt tgtttaaggt gtcggctttc 2683441 gcttgaacat cattaacgct ttgctgcatg ttggttgtgt aatcaatgat gccggactgg 2683501 cgatcagaca atgaacccat catgtctgac atttgcagca cttcctggcc gaccgtatct 2683561 tggacactca gtgccatggt accagacagc ccatcgttgc tgaacgtcgc agattcctgt 2683621 gttgcgcccg ttacaagctg ttctgacgct tttgcggcac tttcagagat tttcgtcagt 2683681 tcgtcgagaa cacctgcttg agagtcacgg atatagccgc tgtagtcgtc cgcaaatttg 2683741 gtcatgccgt cgatgaagct gttaatatcc tcatctgttt gcatcgtgtt gtttttgaga 2683801 gcttcccagc tggctgattc ttcaggtgtg agagccagga ctgattggac gttgccatct 2683861 tgctcttgga tgacttcacc tttaataata gtcaaagagc ctagatccag attatcattt 2683921 agcgtagact tatataaatt taaagagttg taatacttca tcaagttaga aatattatca 2683981 gtttcaattc tacttgaaaa aattgaactt agtttttctt tctgatctat atagcctcta 2684041 ctctgcaaag tttgtattat ttcgtcttcc aaattgtata ttaacctata agcatcattg 2684101 acattattat caaaatcaac caactttttt gttaagtcac caatttgatc atttaatttt 2684161 gaaactgttt tatttaactc tttaatttct tgatttaact catcaatatg tttctctagt 2684221 ttgttgttat gttcctcttg tttttcttga agtgcatttt ctatttcctc taattttatc 2684281 gctgcttcgt tcagacgttt ttttgcacct gaaatatcag tttcaccgtc agctccgtca 2684341 ccctgtagcc catcactttg atttgagcca tcgttttcat ctgcgagttc aatcaaagag 2684401 aaatctgttt tagaggttcc tgtattctcc gtgtttgtat cttgttcagg aacgtttttt 2684461 gaagattctt gatgtttttg tcccgtttca atgttagttt gaacatcatt ttgtgatcca 2684521 ttatcttgag taccctcttc tgatgagcca gtatcttcat ttgttggctg atcatcggat 2684581 gttggaatat cattcgacgg ttcttcagta ttaggagaat catcggttga tggttcttca 2684641 gcatcgggtg ttgttggttt ttcttgttca ggttctttta acccttcaga gatatcttta 2684701 atttcagttg caacattttt gagctcatcc cgctgcttct ctaaatccaa ttttatatct 2684761 tcaatatctt ccttatctgt gtcatcttta ttatcagatg tgtcttctcc atcttccttt 2684821 tcgtcgcttt ccttaggttt aagtaaacta aggcggttct tcccgatatt ctcttgcaat 2684881 tgatttaaat tttgatattt aatagcttca tattgacttt tatatcgaga tagaaatgca 2684941 ttaaacatgt cattctcaat ttttttcata cccatttctt gcaatggcac ttgattttgc 2685001 cttaactttt cagcattgtt caacgcaagg tttgtcagtc ctatttgtgt cttcgcttgg 2685061 ccgatcccgg ttgccaatcc gctcatgcgt tcgctgaact gattcgcctt ttgctgtgcc 2685121 tggatggcat ccagacctgt ccggatttgc tgctgtgttg aatcctgggc tgccaaaagc 2685181 agctttttct gattctcttg atattctttg tacctttcaa ctgtatcaat gaattctttc 2685241 agcgtgtttt tggcttcctc cgccgtagaa gctttttctt ttgtcgtgcc ttgcgcttca 2685301 ttcattgatt tcttcagctc atcgattaag tctttttgct gtttgatttc acctgctaaa 2685361 tcattagagc ttggtttgta aaagttgtac atgacattct ggaattcaga ttctttattg 2685421 acgatcttgt caaattctcc tctgatgttg tccacttttt gcgaaacaaa attccagtat 2685481 aaggccgaca tttttttgtt cattgtcttt tgggcatcct caagctcacg ctgaactttt 2685541 tctttgttaa ccgcattcag gttatcttga atgctgaatt cgagcgttgc cttttgagga 2685601 tggtctttgt catagctcaa aatgtttttt gagaagtctg agggaatgta gacaatcgca 2685661 tcgtatttct ttgaagcgag accggtctcg gccgcgcttc ggtttacgac cgtccacgaa 2685721 taatcaggac gttcacccag aacggccgct acttccttgc cgaactgggc ggatttgtcc 2685781 tcttcatcag actttacctc atcactcaat acgcctgtgt cttcattcac caccgcgatt 2685841 tgccgggtag aattgactgc ttttttcgtt gggtcgtctc cgataaatcg gaaaaacaac 2685901 accggcagca gcaaaatgat gatgacggcg gatattaact tgatcaagct ttttcgttgt 2685961 tctgtcatct agcactctcc ctttcagcag aacataaagg aatttgaact ttttgctcct 2686021 tcccgttttc cacaacatat ccgaagcccg gctgaatctc aggctcctgt ctttggtacg 2686081 ggagaggaat gacattttgc tcagactttt tcatcagcag aatcgcgtgg cggatttgct 2686141 tcatctcagt cgtcaaggag tcatagcctt ttgagaattc gctgtggttt ccgcccggga 2686201 taaagctgaa cccaagatga gcgtatgatt tcatgaagtt agcgagacga tcttgtattc 2686261 tcgtatcaat cgtctgctgg aatctcgtta tcccgtcaat catcagcacg acttgtgaga 2686321 atcgcagatt ttgtgcgtct ccttggcgga cggcttctac atacatggct tctcttgttt 2686381 tgaaaatgtc ttctgctgtt tcaatccact gctcaatatc ttctttcgtt tccaaatatg 2686441 aaacatctga ttccttcgca taatgagata agccgcggtc aatcgagtca aacaggccga 2686501 tcatttcggt ttcatcatca atcagatgtt caagcatgac ttttaggacg tttgttttcc 2686561 cgcgctgagt ttggcctaaa atcaggcagt gcttatgctt gcccaaatca aaatagactg 2686621 ggctgactgt ttcttcatga agcccgatcg gtacagataa aggcttgcgt tccagcttga 2686681 agcggataga caattctctc gtcgacaagc tctcaggcag catcggaatc ggtgccggct 2686741 gctccattga agcaaatcgc ccttgaagtt tctgtacgtc tgatttcagc tcgttgaaca 2686801 tgccgatatc atcatcggcg tcaacaggca ggaacatttg cgcgaaataa agctcttcct 2686861 tttgaatgat gacgcgtccc ggaatcggct caagattgaa tttcggacgg ccgtaaatgg 2686921 aatatccttc tgattgatcc atgagataat ggacaatctt tgttttcaag ttatttaaca 2686981 atgactggcg gacagcattc acccgcgttg ctgtcagcat aaagtagata cccaagcttt 2687041 gtccgtctct ggaaagctgg acaaattccg attcaagctc atgcatctca tccttgacaa 2687101 tgtcaaagtt gtcaatggtg ataaaaatga atggaagctc ttcttcgctc agcgcattgt 2687161 acattttgat gtggctgatt tctttttccc ggaacaaacg tttacggcgg tcaatttctt 2687221 ctttgatgcg aatcatgaac ttttcaattt tccttgactg gtccatcagg aagtaatccg 2687281 cggtatgcgg gagcttcgct aatggcagca gcgttccgtt tccgaaatca aagatataga 2687341 catgaagctc ttcaggtgtg tatacgtccg caaaactcat caggaacgtt gcggctgcaa 2687401 tcgattttcc gtagcccgaa gagccgaaga tgccgatatt tccatcttcc atcatcttat 2687461 aagcaattgg cgcctgtctt tgcagatcag gttcatcgac atacgcaaag tggaaatggt 2687521 ctttttcgtt tgaagggaaa agagtgcgcg gaatacgttc cgcaagcggc ggcagccaag 2687581 ggcttggcag cttctcgatt cccatttcat cttggatgcg ttcaatttcg tcaactacag 2687641 cttcgatttc ggtttgaacg tcttttttcg cgttatcttc ggtatcaacc tcagaaagcg 2687701 ggatcagacc cgtatctgtg acgatcgcga tttcatcctc ggtaccgtag acttcctcta 2687761 agtaaggcgc cccgctccat gcagattgga acagctcata cacttcattg tttccgacct 2687821 gcaaatagcc gcggcctgtt acggtaatgt ttgcggcatc gctgtttttc aaaatttctt 2687881 tactgtcggt ggcatcctgg accttgagcg ctactttaaa gcgcgagtta ctccagatct 2687941 ggtcgtcgat gatgccgcct ggcttctgtg tcgccaaaat caaatgaacg ccgaggcttc 2688001 gtccgatacg cgcggcactg acaagctccc tgataaaatc aggctcctcg cttttcagct 2688061 cggcaaactc atcagaaatt aagaacaagt gaggcatcgc cacttctgct ttcccttgct 2688121 tgtatagctt tgtatagtca ttgatgtgat tgacttgata ctggtcaaac aggcgctgcc 2688181 ttttttttag ctcgctttta atggaagcaa gcgcacgcat actgaagttt ttgcttcctt 2688241 caatatttgt gatcgtgccg aggaggtggg gaatgttacg gaacggctgc gccattcctc 2688301 cgcctttata gtcaattagt aagaaagccg cttcatgcgg atgaaaatgc actgcaagtg 2688361 acaagatgta ggtctggaga aattcacttt tccctgatcc cgttgtcccc gcaagcaagc 2688421 cgtgcggacc gtgtgctttt tcgtgaaggt tcagatacac aatgtcatct ttccctttat 2688481 agccgatcgg cactgacagc gacttcgacg attcacttgt cagccatctt tgctgaatgc 2688541 cgatttcttt tacttccttc gcatgaaaaa gctccaggaa cgataccgtt tccggaatgg 2688601 aattcgtaat gccgacctgg tggttcagcg tccgcagtgt gcgtgaaaac cgttcgttat 2688661 cctcacgctg atgatgatcg agacggaacg gaattcttac cgcttttttc ttttgtatta 2688721 aaatgtcgcc ttcatgctca ttaatgtagc ggacaagagt tgtaatgttt tccgacaagc 2688781 tttcctttgt ttctgcagcg acaattgtcg agatgcccag atgctcatgc tgcccttcta 2688841 aatattcgag aatgacatgc tcagagatca gctgctgatt cgtgatgaca aatacaaaat 2688901 gcggtttgaa ctgcagtttt tctttgtcat cttcgagatc acgctctctg atcaattcgt 2688961 aaagtgaaga caggagctga tctcgggttt gctcattata aataaatcct tttgcataaa 2689021 tatggggcat ttgaaattgc ggaagccact tcatccactc ccagtcttta tactcttctt 2689081 catgaaaaat aaatacgaaa cgcaaatcgt gatagctgtt aaagaacgac agctgtccga 2689141 ttagctggtg aatctcattt ttcacaattt gtgatttacc gacaagcccc atcggacctt 2689201 ctgccaaatc gaccgtcacc ggcgcattac ggatatcttt atagacgcgt tgcatgtgct 2689261 gcgatttctc catgaggtca tcgatatcac gattcgccaa gtctccgcca ctcatattga 2689321 tttcatagct tgacggaact gttcccgtcc caagccgcag ctggagataa tccttgcttt 2689381 caagtgattt ttcccagatc cggtcactga tttcacttgt taagtatttc atttgttcaa 2689441 atgaaggaaa gtgaaattca agaacctgct tttgcttttc agcaagtgcc tgaagctctt 2689501 tccgcttatt gtctaagtaa agcttatata cacgctcccg tttttcctcg cgttttttcc 2689561 gctggttttt atcacggaaa tattgcactg tcgaggtaat gagagtcatc ataaacatcg 2689621 ccaaagaaac gagtataaat atgccgcgcg gctggatgat ggcaactacg cccatcacga 2689681 tcagcatcac aagcggaggc aggatgacga gccacagccc tctgttggtt tgatcgctct 2689741 cctgagaggg aaaactgaaa gaaacgcggt catccggcag atcgtatacc atccgcggcg 2689801 ttcttctgta ctgcggatat tttttctgca tctctgtact cggtttgacc gtttctgtta 2689861 acgctgtttc aaactgggca taatgaacaa tttctaaaag gtcttgttcc gtcaccctca 2689921 tttgcgtgaa gttccagaat atttcatccc ccggcttgag cggcgtattg gcgttgattt 2689981 tctctccgtt caagaagatc gttccgcttt cagggcggac cgaccagctg ccgcctgcac 2690041 ggagcaaaga aaacgtgctt tgttctgcaa atgcaaaatc ttgcggattc agataaatat 2690101 ctgcattcgt tttttctgag gaacatacaa tttcatcccg atttcccgta aaataaacgg 2690161 atttctcagg ttcactgccc gtcaatatca agcgtatatc ctgctgatcc gtttggagag 2690221 taaatgatat atccgtctca atcgtgccga gacaatcatt tcccaggaaa acttcgtatt 2690281 ggccgccgga ttcctttctt ttaagagaaa tcactccgct attaaatgga atggtgctga 2690341 tcgtaacaga atccttcaca tcaggcccta tggtcaccgg atgagacgac gggaggttag 2690401 acagatttaa tttttgaacg ttattttggt aaaaaaccca taatagactc aaatggcgaa 2690461 cccccttacg gccgaatggc agcatgcgat gacctgcgct tcatgtctca cgttatttgt 2690521 catctttttt ctcatctttc ttttctgttt cttttttctc gtcttctttt tccttctgtt 2690581 cttctttttt cgctttttcc tcggctgcgg ctttttcttc tgccgctttc tcttctgctt 2690641 gtttttcttc gtctgtttgt gtctgttctt cgcttgtatc gactaacgat gtttcagaat 2690701 tagactgttt attttcttga cgttcttttt gggctttttc aagctcacta tttactgaat 2690761 caagttcttt ttgtatgtct tcatcatttg tatcctcaga taaaagctgc tgtttatatt 2690821 tagctagggc aaagtaaata taatcattgt attccagctt acggccgata ctgatcgctt 2690881 ctttgtattc tcctcgacca taatcaatcc aatataagaa atgctgaggg tctgattgaa 2690941 gggtgactaa attattttct atatttttgg tttttgcact ccccaggttt tcgacctcaa 2691001 cataggacgt cgccagctga tactgcaccg attcaggcag gctttccgca tcgtacttgg 2691061 acagtgtgct gatgacttca ctgtactgct tgtttaagaa cgcacggttg ctgtccacta 2691121 tcgcctggtg ctttggctgc gcgaaaaata aggcgtacat cgaataaata agtgccggta 2691181 caagcaaaac aatgagcccc aggccgatat atcgctggat gttccacttc tttctcggga 2691241 tatgtatgta tgtttttgct ttggcttcga gctcatcaat atgggtttga atcagctcga 2691301 gcaaatcatc ataggattca gcatctaata tcgcctttgc ctctgcggag aacgtcagcg 2691361 tttcattgaa tttcaggtag tcttcaaacg caaaagcgcc gtcaactgcc aaagccgctg 2691421 ccgctttcag ctcctgccat actctttcct catcacgctc gtaaggagga atgctttctt 2691481 ttactccata atggagaaaa taaggcgtaa gccctttatc gaatacaatg ttttcaggag 2691541 cgacaatcaa attcagcctc gacagattgt gctgctgtac ggcttgaaca agctgatagg 2691601 caaactgcca tttacttttt ttatccttag ctttcatgaa gcggaatgct ttataggagg 2691661 agggaggttg gattgtgatg attacttcat catccgtcac atcgatttct ttatgaaaaa 2691721 atggatttat atctttgatc acgttagctt caagaccgtc gagaagcttt attttttccc 2691781 gttgaaaggt aaatgtatag ccggcatctg ttttctcggc aacagcttct aattggtttt 2691841 ctaaatatga tttttgttca cctgacattc aaccagatcc tttcataata tttcaagccg 2691901 gtctccgttt gtaatgccgc aatcagacag cttgcattct ccggaaaaca ccttatcctt 2691961 gttcaccact ctgatccagt gcccttcgcg cggaggcata gatacgcttt gggcctgcca 2692021 agcaatatca attacttttt tcaccgggtg gtaatctgac aatctgagat caaagacact 2692081 gccgttataa tgtttcaaat ctattgtaat atcaatatac atttaggatc acccttacat 2692141 agaaagagcg ccgtcttctt ttgaatcagg cgctccttcc ctttcatact gttatccgcg 2692201 gatttgattt gcgatgtctt ggtcagtaga ctcaagtgta tttgctgttt gatcaagctg 2692261 ctgattcaca tcttgaagca aatctgacat tttgataaat gaaggtttga gctgctcgta 2692321 ttgatctgcg aacgcttcgc ttgaagcacc ttcccacatg cttttcaaat cagagatcat 2692381 tcggtttaaa cgatcaacct gatttaatac ttcttggctt tcaacgccgt attgcttcgc 2692441 catcgctctt agctcttcgg gtgtgacacg aattaatcct gccatattcc tcattacctc 2692501 ctgtgccatc agcctaaata tgggctaatt cacttatttt tagaacgtca ttattataaa 2692561 aacagttttt cggcatagtc aaacaaatat gttttaattt tacaaaatga gtccaatggt 2692621 ttaccccgaa tcactcaaaa atgacatata ctgtaaagta aataggttta ttttcttaat 2692681 cttctcttca ttctccgaat aatccaaaag acccaaataa ctctccaact cccaaaaaaa 2692741 acctttcaga aaatttgatg ctacagcacc atttctgaaa ggttcagttt tttctttcct 2692801 taattagtct tgcctccgat gactttctta gaagattaat aggataagct gtcgtattat 2692861 atgagacata cactgtcctg caaaaaggcg attacaccgc caaatgtata tagaacgttt 2692921 ctctcatgaa attgtttttt tgcttctgtt ctttgttgtt gattttcaca aacaacaaca 2692981 atcataataa aaggaagggg atgagatgtc aaagagaaat caagcacgaa aagtagggag 2693041 atttatgacc atgccgaatg atccgtttaa atatagtttt gacagacttg aagatgtggc 2693101 tgatcatatc agcgacgttc tgcggtgccc gatcaccata gaggatgtta accacaagct 2693161 gcttgcctac agtacacaca gcgactgcac agaccctgcc cggacgtcta ccattattgg 2693221 cagaagggta ccggagaagg tgattaacaa gctgtggaaa gacgggacaa ttcctgctct 2693281 cttaaaaacg gaccagccga tcagagtcaa gcaaatcgat gaagtcgggc tgagcaatcg 2693341 cgtcgctatt tcgatttgga aaaacaagca agtacttggc ttcatatggg cgcttgagat 2693401 ccaaaaaaca ttgtccgatg aagatctgct gacattgcaa atggcagcaa aagcagtgaa 2693461 aaacaagctt ctcaaacttc aaatcagaaa aacgaaaaat gaagaacgca gccaagaatt 2693521 tttctggaaa atgctgaccg gacacatcca tcaggaggat gatatggcgg atgggttcca 2693581 taagcttgga atggccgctc cttcagagtt ttccgttatg atcatccgca taaatggcga 2693641 gctgactgaa aaaatcgaac agcagctgca atatttacag gaaacgaccc agcaggttta 2693701 cgtgctgctg gcgaccgtag attccaatga acttattata ttaacctcac ccaaaacaga 2693761 tcatcctttt caagatttaa aacagtttgc tttaagtacg caaaaacagc tgaaggagcg 2693821 gtataaaata gaagacgttt ctatcgcttt tggcggaata tacaactcta tttcttttgt 2693881 ctcccgctcc tatcaggaag cattgtccgt cttaaaaacg aaggaacggt tcgctgaaga 2693941 gaccaaacat cttttcagct tttctgagtt aggcatttat caatacttag atgtcttaaa 2694001 tgaaaaacgg aaacaggcgg gccattataa ttactcgctt tccaaactgg aacaatatga 2694061 ccgggatcac cagtcaaata tggtagagac gctagagcgc tttattgaag cggacagcaa 2694121 cgtgaatacc gcttccaagc tgttaaatat acacgttaat acgttgaatt accgactcaa 2694181 gcggatcagc cagatcgctg aaattgattt gaaaaatgtg aatcaaaaat tcaccatcta 2694241 tttagatatc aaacttcggc acatggattt gtgaaatttc acaaatccat gtttttttat 2694301 tttcttaatc aaacaaagaa ttttccaaaa tatcaagcta cactaaaaat atcacatata 2694361 caggaggaga cagatatgat cataggggtt cctaaagaga taaaaaacaa tgaaaaccgt 2694421 gtcgcattaa cacccggggg cgtttctcag ctcatttcaa acggccaccg ggtgctggtt 2694481 gaaacaggcg cgggccttgg aagcggattt gaaaatgaag cctatgagtc agcaggagcg 2694541 gaaatcattg ctgatccgaa gcaggtctgg gacgccgaaa tggtcatgaa agtaaaagaa 2694601 ccgctgccgg aagaatatgt ttattttcgc aaaggacttg tgctgtttac gtaccttcat 2694661 ttagcagctg agcctgagct tgcacaggcc ttgaaggata aaggagtaac tgccatcgca 2694721 tatgaaacgg tcagtgaagg ccggacattg cctcttctga cgccaatgtc agaggttgcg 2694781 ggcagaatgg cagcgcaaat cggcgctcaa ttcttagaaa agcctaaagg cggaaaaggc 2694841 attctgcttg ccggggtgcc tggcgtttcc cgcggaaaag taacaattat cggaggaggc 2694901 gttgtcggga caaacgcggc gaaaatggct gtcggcctcg gtgcagatgt gacgatcatt 2694961 gacttaaacg cagaccgctt gcgccagctt gatgacatct tcggccatca gattaaaacg 2695021 ttaatttcta atccggtcaa tattgctgat gctgtggcgg aagcggatct cctcatttgc 2695081 gcggtattaa ttccgggtgc taaagctccg actcttgtca ctgaggaaat ggtaaaacaa 2695141 atgaaacccg gttcagttat tgttgatgta gcgatcgacc aaggcggcat cgtcgaaact 2695201 gtcgaccata tcacaacaca tgatcagcca acatatgaaa aacacggggt tgtgcattat 2695261 gctgtagcga acatgccagg cgcagtccct cgtacatcaa caatcgccct gactaacgtt 2695321 actgttccat acgcgctgca aatcgcgaac aaaggggcag taaaagcgct cgcagacaat 2695381 acggcactga gagcgggttt aaacaccgca aacggacacg tgacctatga agctgtagca 2695441 agagatctag gctatgagta tgttcctgcc gagaaagctt tacaggatga atcatctgtg 2695501 gcgggtgctt aattcacaat aagcttgcag aaagatttct gcaggctttt ttatttttta 2695561 aaaggaaaaa agagaccatt tcacgaatta tgactatgaa gttgatcata aaggaggatt 2695621 catatggctg ttcagcaata tggcgtgtta aaaggcatag tattagacat gaagcgggaa 2695681 acagatgatg acagtcctca tttccaagtc aaaatgctcg gtgaagagaa tacgtattac 2695741 aggtgcgcca tcaatgtgat gtccagttct gaggaatctg aagtattgta tttggctgac 2695801 gatcagtttg attcgggctc aattaccatc cttccgaaca tgccgtatgg atatacaagg 2695861 atcaatgaag caaaccgtga agtggcactg gattatgtgc ggggcaattt gtttgacccg 2695921 cgggaaatga agcctttgcc tcatgaaatc acgggacctg ataatgattt aaatgatttt 2695981 attgaaacct atatgaagaa agcacaagat gagaaaacgc cggtttatat attcggttca 2696041 aaattcggcc ctgaacaggc tgcagataaa atattcggct ttaccccgac taacggaatg 2696101 cacaatatcc atatgaatca agggaatgca atggataccc gctggaaaaa agacaacggc 2696161 tcttggcatg acgggggtat tctgattcag tttgcagatc agtgggccgc tgtgttttta 2696221 gcgtttttat cccaatcttg gtgtaccgat gaaaacggaa accctgtcag agattgtgat 2696281 catacccaaa cgtctgcgta agatagaaaa agagactgcg gcaagcagtc tctttttgat 2696341 aagattacac attttcaaca gtctttaggc tgtttggcct catatcgctc caatgcgatt 2696401 ggatatagtc caaacaagct tcacgccctt tttgctcatg aacgactgtc cagccgctcg 2696461 gcacatctat aaaacccggc catagggaat attggccttc ttcattgacc agcaccaaat 2696521 atgtgccatc cgcattttca aaaggatttg ccattctatt tctcctccct tatttattca 2696581 actcttccaa tttgacagcg agaaccttgc cgatttgagc cagaggttca ggctgacata 2696641 aatctttatg acggcagtcg atgtcgattt gttcaatctg tccgttaata taaggcttcc 2696701 acgagtcagg ttcaatcggg tcaaaccatt caggaatgat tgttgatctg aaaaacaaaa 2696761 catttccgcg gaaggttttc ggcttatagg aacctaaaat gccgacagaa tttacatacg 2696821 tattcttcaa atttaaaatg accgtttcat ccaggctcgc aagcgcactg ccgtcacggc 2696881 gaagaatctc aatcgccgct tcaaaatcta gcggtttttc ccctaagctg tctggatcat 2696941 acccgcctaa cgccagaagg gcaataagcg cttcctcatc atccggtgcc tcttttatag 2697001 gaaggaagtg gttcggatag gcgtccagca tcaccaacag ggatacttct tctccttgat 2697061 tttgcagctg ggtagccatc gcttgaacga cattcccgcc cagggaccag cccagcagat 2697121 ggtacgggcc ttttggctgg accgttcgga tttgtttaat gtaatcggca gccatgtcat 2697181 caagtgtttt cggaagctcc tcgcgctgcc cgattccccg tgcctgcaag ccgtagatcg 2697241 gataatctgt tcctatattg gtcatcaaac cggcataaca ccagctgagc ccccctgccg 2697301 gatgaacaca gaataaagga ggcttgtctc cgcttgttcg gagcggcagc agaacgtcaa 2697361 gagcgctttg gcttgatccc atttcaagtc tttcagcgag cccggctaca gtaggtgctt 2697421 cgaacaagtt gccgatgctg agttcaacgc cgagcgcttc acgaatgcgg ctcatgagct 2697481 gtacagcaag caaggaatgt ccgcctaaat caaagaaacg gtcatcaatg ccgacacgcg 2697541 gcaagtgaag cacctccata aagaggtcac agagaatttc ttcctgcggc gttctcggtc 2697601 ctcgtcctgt cactgccgct gcgaaatccg gagcgggcag cgctttacga tcaagctttc 2697661 cattcggtgt cagcggcaat tctttcatcg tcacaaaggc agcaggcacc atgtaatccg 2697721 gcagtctctc agcagcatat ctgcgcagtt ccgccgtatc aaatgtttct tccgaaggga 2697781 tgacataagc tgctaaccgt ttatctcccg gctgatcctc acgaacgatc actgccgcat 2697841 cttcaagctg cggatgctga acaagcgcgg cttcaatttc tcccaattca atccggaatc 2697901 cccgaatttt cacttgatgg tctgcacggc cgacatagtc gagagaaccg tcagcgcgga 2697961 ggcgggccac atccccagtg cggtacatcc gggtgcctgg aggaccgaac ggatcagcta 2698021 tgaagcgttc agatgttaaa ccaggccggc ctagataacc tcgtgctaac cccgctcctg 2698081 atacatacag ctctccggca acacccggcg ggaccggctg caggcgttca tccagcacgt 2698141 atacaccaag atcgggaatg ccgcagccga tcaagctgtt tgcccgtaaa gctgccatgc 2698201 ttcggtctaa ttcgatatag ctcacatgca ccgtcgtttc tgtaatacca tacatattga 2698261 taagctgcgg tctattttca gggtggcggt tgtaccaatc ctctaaacgg ctgagttcaa 2698321 gcgcttctcc gccaaaaatg acatagcgca gactgagtgc ctgtccgaga tccggctgtt 2698381 cccgttccgc ctgcataaac tgatagaaag cagacggtgt ctggttcaga acagtcaccc 2698441 cctctttgac aagcaggcgc agaaacgctt ctggcgatct gctgacgtgg tgaggcacga 2698501 ttacaagacg tccgccatgc agcagaggac cccagatctc ccacaccgaa aaatcaaacg 2698561 cataggaatg gaacatggtc cagatatcac ctgagctgaa acggaaccag tgctcggtcg 2698621 ctgcaaataa acgtgttaca ttttggtgag gaatcatcac accttttgga acacctgttg 2698681 agccggatgt ataaatgaca tatgccgtat tcaaagggga aagcggctga gtcctatcct 2698741 tattttttgg attacctgca gggtacgtgt ttagtttctc tgccagctcg ggatcatcca 2698801 gcacgatttt cggcacgttt tcaactggcg gaatgtgatt tgcagcttta gtgttcgtca 2698861 tgataaacgc aggctgtgca tcttttagca taaaagcaat tcgatcagcc ggataatccg 2698921 gatcaagagg gagataagct gccccggcct ttagcaccgc caataggccg acagccattt 2698981 ccaacgatcg gggcagtgcc aatgccacaa attgctccgg cccgacacct tcactaatca 2699041 tcattcgggc aagccggttt gctctttcat tcagctctgc atagctcagt tcctgatttt 2699101 catatacaac ggcaatggca tcaggacgta aagcagcctg cttctcaaat tgctctggca 2699161 aacatgcgtg cggaatcttt tcagatacac tttgccaatc agtcaccatg ctgctgtgtt 2699221 cctctggcgc aagaatatcc agatttccga tttgctcgtc aggatcagac tcggcagcct 2699281 ccaacaggcg catcaatcgg tcagcaagag cctgagcagt ttcccgtttg aaaagatcag 2699341 tgctgtattc aagcagtcct tccattccgt ttggtgtccc gtcagcaagg cgatcttcac 2699401 taatttccag cgtcaaatca aacttggcag aaccgacact gttgattcgc aggctgctct 2699461 ccatatcagg aagatgcagt tcagcgtccg gtgtgttttg gaacgcaagc atgatttgga 2699521 ataaaggatg cgtcgcacgc gaacgagccg gattgagcac ctctacaagt ctctcaaacg 2699581 gcagatcctg attgtcatag gcggccagat tcacttcccg tactctgtct agaagctcac 2699641 gaaagcttgg gtcaccggac gtatcagttc tgagcaccaa tgtattaatg aacagcccta 2699701 caagatcgcc cagcgcatca tcattccgtc ccgcgatcgg actgccgatc ggaatgtcgg 2699761 tgcccgcccc gagccttgtc aataaagcgg cgagaccgga ttgaagcacc ataaacaggc 2699821 tcaccctatt tgcgcgagcc agctcctgca atcgcttgtg aaactcgggc tcaatacgaa 2699881 aatgaatcgt atctccatca tgactcggct cagccggacg tgaataatcg gttggcagtt 2699941 caagctgatc aggcaggttt ttcaaggttt ctttccagaa agcaagctgt ccggcaatca 2700001 agctatttgg atcatcctcg tttccaagca gttcttgctg ccaaagcgca tagtctgcat 2700061 actgcacagc aagaggcgcc cattcgggag atcgtccgtg gcagcgagcc gcataagctg 2700121 tcccaaggtc tctggtcagc ggtgttaagg accagccgtc cccgacaata tgatggacga 2700181 gaagaagcag cacgtactcg tcaggaccga tcacaaaaag ctcggcacga aaagcaggtt 2700241 cagctgcaag atcaaagctg tagcgtacag cttcggcaag ccgatcagaa agctccttct 2700301 cagcaatttc agtaacatgt aactcgggac aggctcgatc ggcatctaaa atatgctgat 2700361 aggatgtccc ctgtgattca gggaagatcg tccgaagact ttcatgacgg cagacgaggt 2700421 cataaagtgc cgctttcagc aatccttgat ccaactcacc tgacaaacgg acagcaaccg 2700481 gaatattata agtaggactc ggtccttcca gacaatgcag gaaccatagc cggcgctggg 2700541 caaatgagag cgggatcttt tcaggccgct cagctctctg caaagcggga catgcactct 2700601 gcgccaaatc aagatgggca gcgagtccgg ctactgtcgg ttcgtcaaag agcttggcga 2700661 taccaagttc ggctcccatt acctcgcgaa tgcggctcat cagacgggct gcaagaagag 2700721 aatggccccc aagctcgaag aaactgtcat cgataccgac gcgtgccaaa ccgagaacct 2700781 ctgcaaacaa gtcacacaat atctcttcct gaggagtccg cggggcccga tcactgacag 2700841 atgtgctgaa gtctggtgcc ggcagtgctt tccggtcaag cttgccatta ggtgttaacg 2700901 gcagctcgtc catctccaca aacgccgacg gtaccatata atcaggaaga ctagccccca 2700961 tataacgacg aagctctgca gtatcaatag cagcatcagc gactacataa gccgccaatc 2701021 gtttgtctcc cggctgatct tcccgtacga caaccgcggc ctgttcaatg tgcgggtgat 2701081 tggcaagcac ggcatcaatt tctccaagtt caattcggaa tccgcgaatt ttgatttgat 2701141 gatccgcccg cccgatataa tccaaagacc catcggcgcg ccagcgggcc tggtctccgg 2701201 tccgatacat ccgagttccc ggcggtccgt atggatctgc aacgaagcgc tccgccgtta 2701261 aatcaggacg atggaaataa cctctggcca agccggttcc tgcaatataa agctctccga 2701321 caacgcccgg cggcaccggc tgcaatccat tatcaagcac atacacctgc gtgttccaaa 2701381 tcggtttccc aatcggagga acgcccttca gcccttcttc aagaaaagct gcggcagacc 2701441 aaatcgttgt ttcagtggga ccgtataagt tcgtgactga acaatgaagg tcttgaagtt 2701501 cctgcaaaag accgctcggc agcgcctcgc ctcctacaag cactctaagc ccccgaagtt 2701561 tctcaggttc actcgttacc aaagcgtgcc acagtgtcgg tgtcgcctgc ataatgttaa 2701621 tatcgaaatt ttcaatcatt tgagctaatg cctgcggctc acggatcgtt tctttctttg 2701681 cgatcacgat ttgcgctccg ctaatcagcg gaagatataa ctccaatgct gaaatatcaa 2701741 aagcgacagt cgtcacagcc aacagcctgt cttcttctcc tagagaaaat gcctcctgca 2701801 tagacagcag aaaattgctt aagcttttct gtgtcacaac gactcccttc ggtcttcctg 2701861 ttgatcctga ggtatagatg atatacgcag gatggtcaag cgaaaccgat acatcctgat 2701921 tttccggcga atagcgtttt ataatctcct gtgtaacagc ctgatcaagc acaagctcag 2701981 gtacagccag gtcatcaggc agactggctg ctatttcctc agtcgttatg atgcatgaag 2702041 gtttcgcatc ctccagcatg taagaaatgc ggtcggctgg aaactccgga tcaaggggga 2702101 gatacgccgc accagtcttg agcacaccaa gcattgaagc caccatctca ggggaacgcg 2702161 gcagcgccaa agcgacaaat tgctccggac caatcccttt ttcgatcaac agacgcgcga 2702221 ggcggtttgc ctcttcattg agctttcgat agttgacttg aatgtcatca cacatgagag 2702281 cgatacgttc tggcgtaaga actgcctgct tttcgaacat gtcctgaagg ctgaccagct 2702341 tctcggattt tgccgtctca ttccatttag aaatgacttt ttctttctcc tctggcaaca 2702401 gaagctccat ttgcccaatc agcatgtcct ctccggcaga agccgtttgc agcagctgca 2702461 aaatacgctg ctgatgaagc ttaatatcag actcactgta tacctcggga ttcgcatcaa 2702521 catcaattcg cagcccgctg ccgtctgttc tgtcatatac attgattgat agatcatcaa 2702581 caggaccggc tgaaagatta tgcgttgtgc cccggacgcc ggcaaagtcg agaccgtaat 2702641 caaacggcat aagattgatt tgagggccaa ataatctatg attttctcct atcaatttca 2702701 gatcgcgcct aagctcttca tggcgatact tatgatgtcg ccgaatactg cggatttccc 2702761 gggaaatttg ctgaatcagt tcagaaaagc tcatcgaaga gcttaccgtc agccggagcg 2702821 ggagaaggtt catcaccata gccggtacat tcagtgacgc ggaccctatc cgacccatca 2702881 tgggcaggcc gagcacaaca tcctcagagc cggtcatacg gtgcacataa acagctgaca 2702941 ccgcaatcat gacttcatgc cagcttcctg agaaatagcg cgccgcttct tttaacgcgt 2703001 ttacatcaga cggaggcaga tatgccgtat gacgaagaaa actgttagat gttcttggcg 2703061 cccgatcagc caagctcaca acttcaggtg catctgcaaa acggtccagc cagaattgac 2703121 gatccttctc atactgctct gatccgcgat aatctgtatc ctcctccaaa atggcctgga 2703181 gagacccaaa ggaacggctt ttagctgttt gtccttttat aagggcagta tatgtacttg 2703241 ccacacgctg ggctatcagg gaaaaaccga agccgtcgat cgctatatgg tgaatgcgct 2703301 gataccaaaa gaaacgatca ggcccggcaa taaacagagc ttcattgaac aaaggggcat 2703361 accctaaatc aaccggcttt gctaaatcag ctttcatcca gtttaatgct gttttttccg 2703421 gatcaggctc agagctgacg tcaatgacgt gcagctgtac atccggagac gggtttatca 2703481 tctgccaagg cccgtccata ttttcaccga agcggacatg cagcgattcc gcttccttga 2703541 tcacgtgccg caaagcttct tcaaaaagag caatattgac tggtccattg atttctatat 2703601 attccgctgt attgtagatt ggattgtccg gatcaagctg ctgagcaaac catatgccag 2703661 tttgcgcccc ggtcaaagaa tattgaagat cttttgtatc aggcatccgt ttgtttaccc 2703721 tccttttata aataatccgc gtttggcagc acttgctggc tgcgagttgt gagcaatttc 2703781 tgccattctt cgatcgttgg gcgttcagcc aattccacga aagtcacctc tgccccttca 2703841 cggcgccatt gttccaccaa tgtcatgatc cttaccgaat caagaccacg atcgagcaaa 2703901 tcctcttgat ctgtgatgtc ttccggtgtt tcttgtagaa gctcagcaat ttgtttacgg 2703961 atattctcac atgtaaacac gttctttttg ccagtgtttg ctgacgtttt ttgaacgtct 2704021 gccggcgcat tctgcagctg atcaagaaga ctgtcagtca tcacggtaaa cgcacagcgt 2704081 ccagccgcat attccagcgc catttgatgt ttttctaatg aaaaatcagc aactgcatct 2704141 cccacaaaaa aggctttaat atcctccata aatgcttcac atgctgtaac aagacagccg 2704201 atatgggcgt aaattcctgt aatgatcagc tgatcgcgtc cctctttgcg catcatttca 2704261 agcagattcg ttctcttaaa cgcgctgtat ctccattttg tcagcacaag atcatcatcc 2704321 tctggtgcca gctcggttat aattttctcc tcataaggac cgctgtttaa tcccgggccc 2704381 caaaagtctg tcagcagcgc acggtcatcc ggattttggc ttcccggctg tgcggtatag 2704441 acaacaggaa tcccaagctg aacacattga ttcttcagct ttcgtatatt cgctgaaagc 2704501 tctgttaccg gagacgctcc cgctgtgaaa gcatcaacaa aatagttttg catatcgtgt 2704561 attaacaaga cagcccgatt cggatcaggc acccatgata ctttgttttg cggcatatca 2704621 gatgctgtcg gcatttgata cggctgaatg gcaggtatag ccatatgaac acttcctctc 2704681 aaattgttgt tttatttttt aaatcctgca agaagcttct cggaaatggc ttcacggagc 2704741 gcttttttgc tgacttttcc tactcctgtc tgcgggaagg attcgacaaa ttcaactcga 2704801 tcagggattt tatatgccgc cagtccgcgc tctctcaaaa atgctttaag ctctgcggct 2704861 tttggggctt catcccgggg aataatgaac acacaagatc tttcgccaag aaattgatca 2704921 ggcatggaga ccattgccgc atcatggaca gccggatgcg ccagcagatg attttctacc 2704981 tcttcagccg caaccttttc tcctccacgg ttaatttgat ccttcgcccg gccttcaacg 2705041 acaatatagc cgtctcgtgt cagcctgacg atatcacccg tacggtaaaa accgtcctca 2705101 gtaaatgaag cggcgttatg ctcttctgcc ttatagtaac ctcgaattgt atacggcccc 2705161 cgcgtcagca gatggcctgt ttcaccaggt tttacgtcgc gatcatgatc atcccaaaca 2705221 cgcatttcat catatggaga catcggtttt ccttgggtgt tgacaatgat ctcctcagga 2705281 tcatccaatc tcgtataatt gacgagaccc tctgccattc cgaacacctg ctgcagcgtg 2705341 cagccgaaaa cagcttttac cctgcgcgcg gcttcagcac taaacttggc accgccgacc 2705401 tgcagcactt gaaggctgga taaatcatca cggcgtgagg atgccgcatc catccatacc 2705461 atcgcaagag gcggaacaag agcggttatc gtgacctttt cccgttcaat taaaggaaat 2705521 gcgtcatctg gacttggaga aggagataat accactcttc ctccagcgta taatacgccg 2705581 agaacgccgg gtgagctcag cggataattg tgtgccatcg gcagcgcggc caagtacacc 2705641 gtgctgtggt cgagccagca gacctccaca ctccgcttca ggctgtatat gtagtcatcg 2705701 tgggtcctcg gaatcagttt cgatagcccg gtgctcccgc cagaaagctg gaggaacgcc 2705761 acatccgatg atttgacttc aggcagtttt acaggttctg catgcaaatc ctccagcggt 2705821 aaaaattcct ctgcctcacc tgcgacaatg atgtttttca aagtcggcag cttgctttga 2705881 acctgtctgg caagcgaacg gtagtcaaaa ccggaataag cgtcgggaat gatatatgca 2705941 gccgcttcag caaactcgca aaaatatgta atttcactgc ttcgatgaga aggcagtgcg 2706001 aagactggaa gcgcccccag acggaaaagc gcgaaaatga cttcaaaaaa ctctttgata 2706061 tttggcaact gcaccacaac acgatccatc tgttgaatgc cgagcttttg aaatccggca 2706121 gccaggcgat cagcccttgt gtcaagctct cgatagctcc aatgggtgtt tccgcatgta 2706181 atggcaatgc gatcaccata tttggctgcc cggtccctta acaaatctcc aaacgtctca 2706241 ccggcccagc agccgttctt tcgataggtc tcagctaact catcaggcca aggcgtaaat 2706301 cctttcagca tgttgtatcc ctccagcaat tcattctgtt catatgtgat ccacgcccat 2706361 tgcccgcagc attgtccgaa actttgcgga cgtctcctga agctcgtcct caggctttga 2706421 accggccaca acaccagctc cagcatacag gcggagtgag cgttcttctg cttctgcaca 2706481 acggatggtc acgatccatt ctccgtcacc ggcatcgtca caccatccga ccatgccggt 2706541 aaagaaaccg cggtcaaatg gttcaatgct gagaatcgct tctcttgcaa gatcagtcgg 2706601 tgttccgcag acggctggcg tcgggtggag cgccgccgcc aattcaagtg cggttacaga 2706661 cgggtcggaa agctctccct taatcacgct ggacaggtgc cacatcgttt ccgttttgat 2706721 cagtgaaggc ttctccggaa cctccagcgt ccggcagaaa ggtctcagcg ctgccgcaac 2706781 cgcgtcagcg acaaccgcgt gctcatgaag atcctttgcg gaagaaagca attcagctgc 2706841 ccggcgctgg tcttcaacag gatcattact gcgcggtctt gagccggcta atgggttgga 2706901 aacgacctgt gttcccatcc ttgaaacgag aagctccgga cttgctccga gcaatgttct 2706961 gcggggagac gtttcctcct gactggacac gtctgcggca aacgtgtagc catgcgagtt 2707021 atgctgagcc agatggcgaa gcaattcatc cgtctgaatc ggttcaggcg atgtcaaatg 2707081 cagcgatctg gacaggacga ttttgctgag tgttccatcg gcaatgcgtg ccagcccttg 2707141 ttcaacacca tttttataat cctcaggttc aggaacaggc tttatgtggt atgtatgccc 2707201 agcctgctgt tccttttcct catgatcaaa ttgaagcggt cctgaccagc gcacttcttc 2707261 aggtacaacg agccgcgctg cttttacttg atcaaaagga acggccccga caacaagcgg 2707321 ccggctttgc cctgattgtt ttgcctgacg taacgcctct gcaattcggc cagaaagggt 2707381 ttccatttgg ttttgcccgt ctgcctccgg tacaatttca catatgcctt tcgctaacag 2707441 tacacgatga ggagacgcta agaaaaaggc gcccggctga tattcatgaa gcaaatgctc 2707501 cgcttttgtt tctgttataa cgttttgatc caacattctc atgaacctcc tttaaattca 2707561 gttacacgcc taaggtcgcg ccgccatcta cgcataaatt atgcatcgta atatgccctg 2707621 cctggccaga aaccaaaaag agcaccgcat ccgcaatatc cgaaggcttg gctagttttt 2707681 tgagcgggat ccctgtttta aatgtctcaa gtgatccttt tatgacttgc tccgctccat 2707741 tctcgtcggc ccataatgac cactgcatgt ctgtttccgt tgatccggga gatacaatgt 2707801 tgcagcgaat attgtattct gcaagctcaa ggccaaggca tttcgtaaac atcacagccg 2707861 cagcctttga agacgcatat gccgccatag atgttcttgg tacaccggca gcattcgatc 2707921 cgactgttac aatcgaaccc gatcttcggt ccatcatata tttgctgact gaacgcgagg 2707981 cgttaaatac gccagtcgaa ttcactgaga acgtcgcctc ccattcctca tcgctaagcg 2708041 aatggatcag tcccgggcga aggacacccg ctacattcac taaaatatca atcggcccca 2708101 tttcacgttc gatgcgcgcc gtgatctcgt caatcgccgc gctgtctctc acatccgcag 2708161 gaaaagcttc tgcatggcgg ccttctgctt tgaggctgct cacaaccttt tccagctttt 2708221 caggattata atcaactgcc gcaatatgtg cgccttgact ggcaagcgtc cgcgcaacag 2708281 cttcgcctat tccttgggca gcccctgtta taaaagcaat ttttccctct ataccctttg 2708341 cattcatatc atcaattcct ttcttcgctc taaatgccaa acagacatcc agcgaaaaag 2708401 actgctgcgc cttgaaaaac gcaatctatt gataatgatt atcattatca attataaaaa 2708461 taatcatatc caaatgtcat gtgacagtca aatataattt cagtgacaaa tattttttta 2708521 aaggcaaggc tgagtatgtc tcagcccatt gatagatgcg gtccgtcagg gtgaagcgca 2708581 aaacgcagcg ccctgctgac caaaacagga agaactgaaa tatgtccttc tcctgaaaac 2708641 tcgcaaaatt ctgcccgtat accttgttca gataaaacgg ccagccgctc ataaagctcc 2708701 cttgcattat cattcatccg gcttttatga tgctgctcta attctcctgc ggcaagcagg 2708761 atattgatag gctgattgtt tttcttggtg agagagacga aatggtccgt tttcttgaga 2708821 ataaacggtt tattccaatg aatggacgga cttcccgcga tatacgtttg aaacgcatcg 2708881 ggctttgtta gcagcacctg cagcacgaaa agccctccga gcgaatggcc aaagattgtt 2708941 tgtctttttt tatcaatctg gtaatctcgt tctatctccg gttttaaatc ctcttcaata 2709001 aatctgaaaa agccctccgc tccgccatgc tccggccatt ctctgccgtc gggcctttcc 2709061 ggcagcttcg attgggctgt tggcattgta aaatcccggt ggcgtgctga ggagaacggc 2709121 tccgctgtct catagccaat gccgacgatc actgcaggga tcaccccggt tttttcgggt 2709181 cggcgtccct gtattcgaac ggcttccgtc atcgttccga agacagaatt ggcatccagc 2709241 agataaatca caggataacc agcgggtggc ggcggcgtac taggtttcga gataaaaatg 2709301 tgataggtac ggttttcatt gcgtgaagac atcatacgca cttccgtacc aggaatcgta 2709361 aatgcgtttg atgtcccgcc atttgtccgg tctgttgttt gttctttcat gcagtacgac 2709421 attcctctcc ttaaactaaa ccgcaatgta tgataatgat tttcactatc aactagacac 2709481 ctcaaataat aggttttctt ccaaagaaag tcaacttttt cccgaataaa aaaggcacct 2709541 tgatcaaata aggtacctgc agactatcaa tatggaagta aaaacctaat aaagatgcgt 2709601 attgtcctat ttgaaataga accttaatcc catgtaaacc tttgattttg ccaagggtcg 2709661 cctctcatgt gatagccatt ccgctcccaa aagccagggt gattttcttt cgtaaattgg 2709721 atgccgcgca gccacttggc gcttttccaa aaatacagat gcggaaatac accccgcagc 2709781 ggaaagccgt gttcaggggt taaaggttcg ccattatgcg cataagccag aagggaagtt 2709841 tccgctaaga aatcatcaag cggcagattg gtcgtccagc cctcttcagc atgtaaaatg 2709901 acgtagcccg cttcttcttt tacacccgct ttttccgcta tatcacaagc ccgcacgcct 2709961 tgccacacat tatcaagcct tgaccatccc gtgacgcaat gaatgtcgtt tttcgattca 2710021 taccgtggaa aggctttgac atcttcaaag cttagcagca tcggatggtc aaccaaaccg 2710081 tatacttgaa gattccattt cgtcatatct tcgtaatatg ggacatctcc ggtatgaagc 2710141 acaggaaatg aagtggtgac gttttgattt ggcggcactc ttccagattg atcggactgt 2710201 cttgtttttc cgaaatacat atgggcctcc tttttgttaa cctaatttaa aatcatgttg 2710261 acaatctttt tgttctttat tactctatga ttgtgtatgt caacctaagg gggaacaacg 2710321 atgaaacaac gtaaacttcg tgcgggagat atggcgctga ttggcatgtt cgccgcactt 2710381 atggctgtcg gggccaacat tacatcagta gcaccctttt tacaagtagc cggcattccg 2710441 ctttcgatgc agccgttttt ctgtctcttg gcagctttgc ttcttggcag caaacgggca 2710501 gcgattgcca tgattgtata tgcacttgtg ggattggccg gagcgcctgt gtttgctcaa 2710561 ttttcagcag gcttcgcacc gtttgcaggg aaaagcggcg ggtttattat ctcatacatt 2710621 ccggcagcat ttgcagcggg atggttttta gaacgaaaca ttcagccaag taaaattcga 2710681 tttctcattg cttcacttat cggaacggcg atcatgtatc tcatcggcac tacctatatg 2710741 tatcttgcac tgaagctgtg gattcatacg ccagtgagct acggcacggc ttggggcttt 2710801 atgatttggt ttatggtaaa agatacagcg ctggctgtga tactgtcgtt tatcgcacca 2710861 gcaatctacc gctctattca taaagcaacc ggctttaaca gaaatcacat atcatctacg 2710921 taaaaaccgt tctattggac ggttttttta tcataacgag aaaaggctcc ccagtaaagg 2710981 ggagcctttt tcctataaaa caagcgctgc aatccagcca aagatgacaa gcggaatatt 2711041 ataaaatata aatgtcggca cacaagtatc ccaaatgtgg tgatgctggc cgtccgcact 2711101 caaacctgaa gtcggcccaa gcgtactgtc actggcaggt gaaccggcat cgccaagcgc 2711161 agcagcagcc ccgataatcg caatcgttgc catcgggctg aatccaagct gcatgcatag 2711221 aggcacgaaa atggttgtga taacaggaat ggtcgcaaaa gaagatccga tccccattgt 2711281 aattaataag ccgacaatga gcatcagcaa tgcgcccaag gactgactgt gtccgataaa 2711341 accagctgac gttttgacca gtgactcgac atctccggtt ttcgtcaata cgtttgaaaa 2711401 tccggctgca acaagcatga caaagccgat aaaggccatt aaaaccattc catcagtaat 2711461 cagtgagtcc gcttcatcac gcttcatcac accgctgaca aacagaacaa tcagaccagc 2711521 gagcgccccc ataatcattc cttctactcc caaagtctga gataagtaaa gctggacgcc 2711581 gagtgacaca acaatggcta gaaccgcgat accaatactt tttctcgtat atggcgatgc 2711641 ttctgcacct gaaatgtctt ttgtttcata ttgtttcggt ttacggtata cgatcactga 2711701 taaaataagg ccgacaacca tacctgcaac tggaataatc agtgcgtacg gaatatcagc 2711761 aagcggaacg tttaacccgg catccgccat attgtccttc agcatgcctt ggaagatttg 2711821 gccgaaaccg accggaagca aaatataagg agccgttaag ccaaatgtaa ttacacacgc 2711881 gatcagacgg cggtccattt caagttcatt aaagattttc aaaagcggcg gaatcagcac 2711941 cgggataaac gcgatgtgaa ccggaacgac gttttgcgaa aaacaagata caattaaaat 2712001 aatcagcaca atcagcacct tagacagtgc tttttttcga gaatcttctt tatttccgat 2712061 taatttaacg gaggcttcca ccattgcgtc cggaagaccc gttttcgtca aagcggcggc 2712121 aaacgcgcca agcatggcat agctaactgc aacggtggca tttccgccga gaccgtctgt 2712181 gaaagcttta accgtttcgc caagaccgag cccgcctgtt aacccgccgg ccaaggcgcc 2712241 tataattaat gcgataacaa tattgacacg cagcaggctt aatacaagca taagcaggac 2712301 tgcgatgacg actgcattca tgatgatacc cctccaaaaa tcctttagtt tgctaatgta 2712361 gtagataaat aaagtacgaa cgtatcgtat cataaccgat ccactttagt caactaaaga 2712421 tttcggaaga aaaaatccct gccgcatcat acagcaggga tttttcatta ctcgttttta 2712481 tcttcttcca atgtaaatcg ctccgcaagt gtagccagtg ttcttgccat aacgccagta 2712541 gccccggccg gtccgaagca ggttgcttta ttggcagtcg ctgtgcctgc aatatcaagg 2712601 tgaacccaag gtgttgactc agcgaattca ccaagaaacg ttcctgccat aatcgcatgt 2712661 ccctcgcgtc ccggtgaatt gctgagatcc gccatttggc tgcttttcac gcgtttttta 2712721 tccttctctg ttatcggcag ctgccagatc gcctcgccgc actcttgtgc agcatcagct 2712781 acctgctggt aaaagctttg atcatttgtc attgcaccgg ttgtttctgt tcctaatgcc 2712841 acaacgacgc cgccggtaag cgtagctaca tcgacaagaa ctgatgcgcc atgctgtttc 2712901 gcgtatgtaa tgccatctgc aagcactagc cttccttcag catccgtatt aaggatttct 2712961 attgtttttc cgcttaaaga tacgatcacg tcatccggct tcatggcccc gccggagatc 2713021 atattatcgg ttgatggaat aacgcacagc acgttttgtt caggacgaag ctctccgatc 2713081 gtttccatag ccccgagaac cgcagctgct cctcccatat ctgatttcat gccaacaatt 2713141 ccagatttcg ttttaatgga gtagccgcct gtgtcaaagg taattccttt cccgactagt 2713201 ccgacgacgt cttcccattc ctttttgccc tgatatttca acacaatcat tttcggcggt 2713261 tcggtggagc cttggtttac cgcaagtatt ccgcccatac cgagctcttc catctctgat 2713321 ttctccaata tctcacactc aaaatcatat ttcgccgcaa gctcttcagc atacgaagcg 2713381 aggtcagtcg ctgtcagcat gtttcccggc atattcacaa gcgttctagc cgaatttgtc 2713441 ccttgtccgt atgcctggcc gacgcgaagc cctgcctgca cttcctgtgt atcttcatct 2713501 gttacaacat acacggcttc aatttgtttg tcaggctcat ttgatttatg cttataatcc 2713561 tgcacctcat aggaagcaag caggcagctc tcagctaaag catgagcggc atcggctgga 2713621 ggcacgtctt ccgaaataaa cgtatcaagc agaacagcag tttcttgttt tcgatcttta 2713681 tgaatggctt gaaaaacatg agcaaaacgt tccttcgcct gttcaaacga ataatttgct 2713741 tctctcccca ggccaacgaa ataaatccgt ttcatacccg cagaagatgg agggaatact 2713801 tttgatactt gattcggttt cgcagagaca tcaccctctt ttaaaagctg tgtcagatgg 2713861 ccttcgagca tttcatcaat ttccaacgct tttcctgtca gctggctttt ttgaaaaagc 2713921 ccgacaacaa gggtttctgt atgctctgat tgttgaaccg cataaaacat gaggcttaca 2713981 ctcctaacgt aatgggtatt tgtaatgaac aatggtataa taggaaaaac attctttcca 2714041 ctatacttat tttaacaaac aacagtctaa gacttgcttt tttcttttga aacacgaagg 2714101 atttttcaaa tagaaaggat gtcgccgatg gaacttttaa cgaattttcc tttattatca 2714161 agcctggccg caattatttt tgctcaggtc atcaaagtgc ccatacagtt tatcgtgtcc 2714221 agaaaactgg actggtcgct ggtcacaagc acaggcggca tgcctagctc tcactccgca 2714281 gcggtcactg cgctttctac aggcgtagcc ttggagcatg gattagactc ctcactcttt 2714341 gcggtttccg ccattttcgc cgtcataacc atgtttgacg caactggcgt cagacgtcac 2714401 gccggtgagc aggcaacagt cattaataag cttgttattg attttaaccg tttcgtaaat 2714461 gaagcgaagg acttccctaa ggctgcagag aaagaaaagc aaaaaaagct gaaagagctt 2714521 ctcggacatc agccgatcga agtctttttc ggaggattaa caggtatttt actgacattg 2714581 gtactcgctt actttttcat gtaaaaaaaa cgctcctgct ttcgctggag cgttttattc 2714641 tttcaccgtt ttatattgat ttctgaacac ttgcaaagat tttgtttcat tgagcttctc 2714701 aagctcatcc tcggtaatct ttcccgttcc ctttttaatc acatatacat caagggtttt 2714761 tttgccccat tcattgtata catctttgac tgtctcaaag tacagatcaa ggcggtttcc 2714821 cttaatagct gatcctgtgt cggccacaac tccgagaccg tagttcggaa tgaataaaat 2714881 tgttccgatc gggaaaacgg acgggtcagc agcaaccgtg gaatataaat cccgtttcac 2714941 tttcacacct gaatatgtaa gcccgtataa tggatcaccg ggatttttgc ccgtcgactc 2715001 agctcctgct gtgtagcctg ttgctgttac tctttggact ggatattcat cccaatcaaa 2715061 tgcctcttct aacggttttg ttttatcctc agccgcggac gtggtttgtg tttgtttctg 2715121 ctgcaatgct tttaatctca gtcctgcatg cttcaagtgc ttttcctgat gttcctgcac 2715181 ccattttgac aagtccttcg cttcaattcc tgacactgat aaaaatgtcg tgccaaatgc 2715241 aagcagaaat aaacaggtca tcagcaaacg tctgatcata ttcaacatca ttcacctctc 2715301 ctccgaatca ttgttcccaa gtggagagag cattattcaa aatggtgaat gagctgaacg 2715361 cataaaaaaa gctttcttta gaagaaagcg gcatttaaaa catttgatat cctctttttc 2715421 taagcatgtt gatcgctata ccggacacga tggcgccggc caaaccgctg actaaaatca 2715481 gcacatcagc agccgctaat gataagacac gatgaaacag gctggcaaag gattctcccg 2715541 gcgactggac atagctgatc agcttttctt tgctgataat gaaaaggcat acaattggat 2715601 aaatcacagc cataatccaa gacattctca gcagcatgtt taataagaaa ccgattccaa 2715661 aaaacaagac aaaaaacaaa acaattgaga tgattacgac tggcagacta atcaacctat 2715721 tccacccccc tgcgttgttt ttagtgtaac gcgggggctg aaataaagtc aacggctgga 2715781 aaaagaatga ctgtcttttc ctgtcccctg gcaagacgga caagtctctg aaccgccgag 2715841 aatcaattga aaatatcctt tccctgaaca aaatgggcat gcatgtgaag cggttgtcgt 2715901 tgcagttttc atctaatcat cacccttttt cttaattttc tgataatata ccatatcaag 2715961 ctgtcaacaa taaagtcaga tcatgtgaca aatcttttga tgtaagcgga aacatacttg 2716021 ttttcctctc gttctctttt tattttggcg ttttttaata aagaaaaccc gcttccgcgg 2716081 gtttttagaa aaacttgaac ttgccttttt tcaatgtcag tccgagtccg ccaatcataa 2716141 acagtgagcg gttatcaatg acttttttca taaacgaagc gggcgtgcct ttcagctttc 2716201 tgccataaac aaccccaacc gcgttatgct cgccaagaga agccactgtt cccttaatgt 2716261 ccggcttgaa ttcctcaagc tctccgcctt taataagcct gccaaggttt ttagcgaccg 2716321 ttatgccctg ctgcattgca atttgcgcag tcggcggata cgggcgctct gtatcttcat 2716381 tcataaacag cgagctgtcg ccgagaataa agacattgtc atgtcccggg gcgcggagat 2716441 cagggttgac tttgactcgg ccgcgcatat tctcaaaacc ggcttcctcc acaatcggat 2716501 ggccgcggac acctgccgcc catacaacgg tttgcgattt gatctgctct ggttcttcat 2716561 cttttttgcc gactctgact ccttctggtg tacattcttg tacagccgtt ccgatcttga 2716621 actcaactcc gttttcctca agataatgta cggcgtaatc aacaagttcc ggatcaaagc 2716681 ccggcaaaac ggtcggcgct gcttccacac aaatgatgcg gacaaggctt ctgtcaacgt 2716741 catattcctt acagagctcc ggcacgcgag cagccagttc gccaagaaat tcaattcccg 2716801 taaatccggc accgccaaca acgatcgtta acctgtccgg ccgtttttcc gcttccgtat 2716861 tgtaagtcgc aaactgcagc tcaatatgtt cccgcagcag gcgcgacgtg ttgatgttgg 2716921 caatcggaaa cgcatattct tttaagcctt taatgccgaa cgtttcaggc acggcgccga 2716981 gcccgatgac taaataatcg tactgcaatt ctccattcgc aagcacaact tttttctcat 2717041 caattttgat tgcctttacg gtatcctgta caaaattcac ccgtgactgg ttgattacat 2717101 cttttatctg ataacggcag cggtcatgat ggagcgtacc cgcgctcgct tcatgcatcc 2717161 atgtcgtttc ataatgataa ttgtgtttat ttacaagcgt aatgtcagca tcattcggcc 2717221 cgacatactt cgtcagcctt gtcaccgtca tcaatccgcc atatcctgca cctaaaatca 2717281 cgattttggg cttattcaat gccatcacat ccaccttctc tttttttgct tttgttagac 2717341 ccataataaa atcatcattt gtgttagctt cagcttattg gcgggatttt atgaaatata 2717401 ttgaaaagtt ttttgtgaag tccttacccg tagcactatt atcatgttta tccggctggc 2717461 ccaagaaaca ttcagaaaaa gatcatttca tttggttatt atcgtagcgg cctgcggaaa 2717521 tattttcaag aacggatggg cacgttagat ccttacgatt ttttctgctg actcgtcaat 2717581 ttgaacggca atatggtata attaataaca attttcattt aggaggcaat tttcgtatgc 2717641 gagaggatac aaaggtttat gatattacaa ttataggcgg gggaccggtc ggcttattca 2717701 ccgcttttta cggcgggatg agacaggcaa gcgtcaaaat tatcgaaagc ctgcctcagc 2717761 tcggcggaca gcttagcgcc ctataccctg agaagtatat atatgatgta gcgggattcc 2717821 cgaaaatccg cgcgcaagag cttatcaata acctaaaaga gcaaatggcg aaattcgacc 2717881 aaaccatttg tctggagcaa gcggttgaat ctgttgagaa acaagcggac ggcgtgttta 2717941 agcttgtaac aaatgaagaa acccactact ctaaaacggt catcataact gcaggaaacg 2718001 gcgcattcaa accgagaaag ctggaacttg aaaatgccga gcagtatgaa ggcaaaaacc 2718061 tccattactt cgttgatgat ctgcaaaaat tcgccggcag acgcgttgcg atccttggcg 2718121 gtggagattc cgcggttgac tgggcgctta tgcttgagcc aatcgcaaaa gaagtatcga 2718181 tcattcaccg ccgcgacaag ttccgagcgc acgagcacag tgtggaaaac cttcatgcgt 2718241 cgaaggttaa tgtcctgaca ccattcgtcc ctgcggagct gatcggcgaa gacaaaatcg 2718301 aacagctagt gcttgaagaa gtgaaaggcg accgcaaaga gattttagaa attgatgact 2718361 taatcgtcaa ctacggtttc gtttcatctc ttggaccgat caaaaactgg ggcctggaca 2718421 tcgagaaaaa ttccattgtc gtgaaatcaa caatggaaac aaatatcgaa ggcttctttg 2718481 cagcaggtga catttgtaca tacgaaggaa aagtcaacct gattgccagc ggcttcggcg 2718541 aggcaccgac agcagtgaac aacgccaagg cttacatgga cccgaaagcc cgcgtacagc 2718601 ctcttcactc aacaagtctt tttgaaaata aataataaaa aaaggagctt gtgtctgcga 2718661 cacagctcct tttttatttg aagatattta tataattcaa tgcagttcct acaaccagcg 2718721 caatcacaag ggctgcgact acccagatca ttgccataat aatgcggtcc tgaatctttt 2718781 gggacttcgg tgttttttct tcgttttggg ccatcttatt cgctcctttc ccatgtccat 2718841 gccataaaga aagcctggtg ctgaacgacc aagctttgct gaacgtatat cattcgcgtt 2718901 ttgatccgct ctctaagacc attcgttaaa actatgatac ctaaactcac cctgcatgac 2718961 aagcttcggc acttgcacca cacctgccag caaatcataa tgtttgacat cctaaataaa 2719021 acagagtaca ttatataagg cgaacatttc atatattata cttttaaata ttcgttttta 2719081 ggagtgaaaa ccatggaaaa cgtatttgat tacgaagata ttcagctaat tcctgcaaaa 2719141 tgcattgtga atagccgttc agaatgtgat acatccgtac gtttaggcgg acatacattt 2719201 aaattgcccg tcgtccctgc caatatgcag acgattatag atgaaaaact agcgatttca 2719261 ttagccgaaa atggctactt ttatgtgatg caccgatttg agcctgagac acgaattgat 2719321 tttattaaag atatgaacgc acgcgggtta ttctcttcta tcagcgtggg cgtcaaagat 2719381 gaggagtatg aatttgtccg ccagctggca gaagaaaatc tgactcctga atacgtgaca 2719441 attgacattg ctcacgggca ctcaaatgct gtcattgaaa tgatccagca ccttaaaaaa 2719501 catttgccgg acagctttgt tattgctggc aatgtcggaa cgccggaagc ggtcagagag 2719561 cttgaaaatg cgggagcgga tgccactaaa gtcggcatcg gaccgggaaa agtatgtatt 2719621 acgaaaatca aaacaggctt cggcacaggc ggctggcaat tagcagcgct gcgctggtgt 2719681 gccaaggctg ccagcaaacc gattatcgcg gatggcggca tccgcaccca tggcgacatc 2719741 gcaaaatcaa tccgattcgg cgcaacgatg gtcatgatcg gttcactatt tgccggacac 2719801 gaagaatcgc caggccaaac gatcgaaaaa gacggaaagc tttacaagga gtacttcggc 2719861 tcagcctctg aattccaaaa aggcgaaaag aaaaatgtcg aaggcaaaaa aatgcacgtg 2719921 gcgcataaag gctcaatcaa ggatacactg attgaaatgg agcaggatct tcaatcttct 2719981 atttcttatg caggcggaac aaagcttaac gccatccgca atgtggatta tgtgattgtg 2720041 aagaattcca tttttaatgg ggataaatat taatcataaa aaaacgccaa gtcagcggtt 2720101 ctccgcttga gttggcgttt tctgctactt cttcagcaaa gtaagcttat atttgctttt 2720161 tgagtttatc ttccatcagt tctgccattt gttttgcatt tggattttct tcattttgca 2720221 actgttcaat gacgttcata taatccgttt catttcggtt ctggcttaat ttatatgccg 2720281 cttgaatgtc ttccacctta atcttaaatc caacaatacc tttcaattca ctttctaaga 2720341 gttttggaga aagcttatcc cataacacag gattgtcacg atgtttttcg tatttctcca 2720401 acatgattgt taattcttct gctaattcat ctttctctaa catacttgct tttccataca 2720461 tgtggacagc ctgataattc cacgtcggaa cattttcgcg cgaataccag gaagaagaaa 2720521 tataagcgtg cggtccctga aacatcacaa gcacatcttc acaggcttca aacgttctcc 2720581 actgaggatt tccataagcg aaatgccccg taatatagta atgatcgtct tttttattga 2720641 atcctaacgg caaatgtgtg gcaattggtt ttccttgttc tgttgtgaca accgtaccaa 2720701 aggagttttc ttgtacaaaa ttccaaattt cttcagcatt tgtgacttta aaatattttg 2720761 gaatatacat catcatccac ccttcgaaaa atattatatg agtgttttag ccatgattaa 2720821 atccgtttgt tcttcatcac ccatataaaa tgagtgggcg ccggtctgaa caaaccccat 2720881 tttcttataa aaggcaatgg cattttcatt tttttcccac acacctagcc aaatgttctt 2720941 tttattacgt tccagcgcaa tttctatcgc tttattcagc agatgtttgc caagcccatg 2721001 tttttgaaag ctgttcttta tataaattct ctcgatttca agtgattcag cacccatttc 2721061 ttcagactga gcatcatcga tattgacctt tacatatcca gcgatttcat gatcaaagta 2721121 aataaaaaag aattgcgaag acatattaga taactctttt tccagctgct cagtgttaaa 2721181 tgcgctttct aaataggctt tcatattttc aggtgagttc tgttctttaa aagtgtcatt 2721241 gaatgtttca atactcaatt gttgaagtgt ttgtaaatct tcccggctgc attttttcat 2721301 ttttacactc attgttcgga ttcagcccct ttatttaaaa ttcaattgtc ttgtgtccct 2721361 tttatatatt taaacacgga acacatactg accttgttac cattccaaaa atcttcttca 2721421 tcaccaactc cctatcgtga ttttgttgta aatgcaataa aatatactcc gcattaaata 2721481 tatcgtaact ttgctgtatt tacaacaaaa atcaaacaac aaagcagcgt ttctcttgcc 2721541 gaagttcccg gaactctctg catcatttcc ccataataaa aacgcctccc ttaacgatga 2721601 tttatcgcta agaaaagcgt cagtaatagt tgctatccgt ttttagtgct tagcactctt 2721661 caggcttgcc tgcattcgtt gctgttctga acgaagaacc gcagccgcat gaagcgatgg 2721721 cgtttggatt gtcgatggtg aagccgccgc cgagcatgga ttgtttataa tcaatcacgg 2721781 tgccgttcat gatgtcaagg ctttctttgt caactagaac agtgatgccg tgctgatcaa 2721841 acacactgtc tgattcactc ttttcatgct caaagcccat gccgtaagaa agtccgctgc 2721901 agccgccgcc tttgacgcct acacgcagaa acgcgttttc ttcttcatgc tctttcatca 2721961 tatcttttat atgcaaagct gctgcttctg taattgttac cgggttgctc atcattatga 2722021 acctcctttt aaaaaccggt tgctgtcttt tattataaac atgatcgttc caattctcaa 2722081 acaaggtgtt ttacaagaaa tagacaccct cacaaacggt ttcagccggc cctgtcatca 2722141 ttacatggcc gttatctttc cagtttatca ccaaatcccc gcctgctaaa tgcaccgtga 2722201 tgtcttgatt tcgctttgat acgccgttta atacagatgc gactgccgct gcacatgctc 2722261 ctgtcccgca tgcctgagta atccctgatc cccgttccca gacgcggaaa tgcaattctt 2722321 gttcattcac ggtttcaacg aattccacat tgatgccttc cggaaatctc ggatctttct 2722381 caatcaccgg ccccagtgtc gttaagggtg cctgttcaat gtctgcgatc ggaaaaacga 2722441 tatgcggatt tcccattgaa acggcagtgc ctgttagttc tacttcacca aatgccatcg 2722501 tttcattgat tgtgtgctct tccccgccgt caagcatagg aagctcggat tttgtcaagc 2722561 gcggttcgcc catatcgaca gtgaccacat tcacttttcc gttttcgact tgaacctccg 2722621 ctttcacaag cccggagaga gtttcaatca gaaaagatgt ttcctcaacc agcttatgct 2722681 catatgcgta ttttgcgacg cagcgcaggc cgttgccgca gtttttccct tcagacccgt 2722741 cattattaaa aatccgcatt ttaacaggcg cttggtctga tgggcatatc aggatcattc 2722801 cgtcggatcc gatccctgta taaacagaag aaacctgaat tgcaatctct gacagttttt 2722861 cttctggaag ctgttcttca aattgattca cataaatata actgtttccc aggccgtgca 2722921 ttttggtaaa tcgaaatgag ttcataggtg cctccaactt tttttctttt tcttagtata 2722981 aaagctatta taagcggaca caatacaatt atcccccgtt tttcatacat aaaagctcct 2723041 tgcactgacg caaggagctt ttatcgttta tataaacatg ccggcaatgg ctgcgctgag 2723101 cagattggct aatgttcctg caagaacagc cttcaggccg agacgtgcga tatctgaacg 2723161 gcggctgggc gctaaaccgc caagcgtacc aagcataatc gcaattgatg aaaaattggc 2723221 gaatccgcat aacgcgaaac tgataatggt agcagttttc ttagaaaact cgccgatgtg 2723281 cgaaccgaag ttagaataag cgacaaactc attcagcacc aatttctggc cgatatagct 2723341 tcccgcctgc aatgcttcat gccaaggcac gccaatcaaa aaggcgatag gagaaaacac 2723401 atagccgaga atggattcta atgttacgcc ttttaaaccg aacaagccga aagccccgcc 2723461 gagaataccg tttactacag cgattaacgc aacaaacgca agcagcatcg ccccaacatt 2723521 taacgcaatt tgcagtcctg ttgacgctcc ctttgcagct gcgtcaatga cattggctgc 2723581 gccttcgcct tcatccattt tgaaatcgct ttttacggtt tgcgtttttt ccgtttcggg 2723641 tataatcaat ttaccaaaga ctagtccagc tggagcagcc ataaagctgg ccgccagcaa 2723701 gtactcaatc ggaataccga gaagcgcgta cccaaacaag gtagatcccg caactgccga 2723761 tagaccgctc gtcataatcg taaacaactc agagcgcgtc agcccggcaa tcaggggttt 2723821 gatcactaac ggagattctg attgtcctac aaaaatattg gcagcagccg ccagagattc 2723881 cgttttgctt gttccaagga gcttcgacaa tccgccgcca atgacacgga aaacgagctg 2723941 catgattttc aaatgatata aaactgcaat cagtgctgag aagaaaatga taacgggcag 2724001 tacacttaat gcaaatgccg gactgtctcc gacctttaga agcggtccaa aaataaaact 2724061 gatgccttca ttcgcatagt caatcagaag ctgtacacgg cttgaaaacc ataaaaaaac 2724121 agcgcgtccc gcttcccatt tcaacacgat gtatccaaac gccacctgtg tgcataaacc 2724181 aacgatgacg gttcttatct taatattgct tttcttttct gaaaataaaa acgcgatagc 2724241 aatgatcgca actgcgccca gcagccccca cagaacattc atgaatactc gtacacctct 2724301 taaattttat ttaaaaaaat atcttttata cgataacaat aatatttttt gatgtctaca 2724361 cattttttta gttcttttgt acggcaaaat aaaaaagggc ctgtccaggc ccttttcttt 2724421 aaaacattgg attttcttca ataaaggtat atatattctc aacaagctca gcaggcgttt 2724481 cacccatgac gacttctccg tttaccagag cgaaaagcga ttccatacat gtcccgcagt 2724541 agcttaagca gccatattca aggacatcaa ggttgggatc cttctccaaa atcgcccggg 2724601 cttcctgaga gccgtgagcc agattgctga cacaaaattc aatcattgga ttcatgcggt 2724661 ttcacctcac atatgtccat tatcgcgaat ttttcactat tcgtcaaaga caacggatga 2724721 ttcaaaattt attatcgtaa catattattt ctcaaataac gttttactaa tttgtgtttt 2724781 caggctaaat tgtaggttat tttgaaacta ttattgtgat tttagatcaa attcgatata 2724841 attctagatg ttattttaca tagttcgtat tttcttcaat gtatctatca tactcttcgg 2724901 attaaagggg aattcaaatg aaaaaattgg tcttgatcgg cggaggttac gggaacatgc 2724961 gcgttcttca tcgcttattg ccaaaccagc tgcctgatga tgtttcaatc acgttaattg 2725021 acagaaatcc ttatcactgc ttgaaaacag aatattatgc ccttgccgca ggcacaattt 2725081 ctgaccatca tatcagagtg tcattcccag agcaccctcg cctggatgtc caatacggtg 2725141 atatcacatc aattgatatt gtacaaaaac aagtgctgtt ccaagatcgt gaaccgattt 2725201 cttacgatga cgccataatc gggctcggct gtgaggataa atatcacaac gtgccgggag 2725261 cgcctgaatt cacctacagt attcaaacca tcgatcagtc ccgcgaaacc taccaaaagc 2725321 tgaataatct gagcgctaat gccaccgtcg ccattgtcgg agcgggctta agcggcgttg 2725381 agcttgcaag tgaattgaga gaaagccgtg atgacctgaa cattattttg ttcgaccgcg 2725441 gtaatctcat tttatcaagc tttcccgagc gtttaagcaa atatgtgcaa aaatggttcg 2725501 aagagcacgg tgtccgcatt attaacaggg caaatatcac aaaagtagaa gaaggcgttg 2725561 tgtataacca cgatgatccg atttctgcag acgccatcgt gtggacagcc ggcatccagc 2725621 caaacaaagt cgtcagagac ttagatgtgg agaaggacgc acaagggcgt attgtattaa 2725681 cgcctcatca taatcttcca ggtgatgaac atctgtacgt tgtcggcgat tgcgccagtc 2725741 ttcctcatgc accgagcgcc cagctggcag aggctcaagc agagcagatt gtccaaatct 2725801 tgcaaaaacg ctggaatgga gaagccctgc ctgaatcaat gccgcagttt aagctgaaag 2725861 gcgtcctcgg ttcactcgga aaaaaagccg gcttcgggct tgttgctgac cgtccgctga 2725921 tcggccgtgt tccgcgtatg ctgaaatccg gcttgctgtg gatgtataaa caccataacg 2725981 gttaatgata gagaagaacc gctgatcaag tcagcggttt tctgtatacc catgcttctc 2726041 catttcctca taaacgtctt ttaattttgg attgccttca ccgacaattt tgtcttctac 2726101 aagcacaagc ggataaaaat actcgtcatt tctgattttt tccgcaagct ctttcgcatg 2726161 ttcattgtca ggcggctcat gaatatcgat gtactgcatc tcaaaaggct gatttggata 2726221 ttttcttttc agcgcagcct caagccactc gtatgtatcc ttggctgtcg gcatatttac 2726281 acagctcgca caaacgtttt ctgccccgta cacgcttagc atgactggtt tcatcacttg 2726341 tagacgcccc cttctcctat gtaagtcctt tcttttaagt atacagagcc taagggcgtt 2726401 tttatagaaa aaaaccgttt ttgtgttgaa gtctgaatgt gctataatag ggaaagcaac 2726461 tttgcaaacc aaacaataga tttttattgt tacactgaat ataatggttt tatgacgacg 2726521 aaaggagcga atgtcatgac tgaagttgaa atgaaagaac aggtgcagga agtactggac 2726581 aaacttcgtc cgtttttact tcgtgacggc ggtgactgtg agcttgtaga cgtagatgaa 2726641 ggtatcgtta agcttcgtct tctaggcgca tgcggcagct gcccaagttc aacaattacg 2726701 ttgaaagccg gaattgagcg cgctcttctt gaagaagtgc cgggtgtcgt tgaagtagaa 2726761 caagtctttt aataaagcag ccaggctgat atttgatcag cctggctttt ttattagaga 2726821 tgttgatcaa accatgagct gatataattc aggcgcttga tccgctgtct tgggtgtccg 2726881 gtgcgtgata aattgtgcga tgcattcgga aaacggacaa gcttggtttc cttgcccatt 2726941 tttttcagag cgataaacag ctgctccgcc tgctcgatcg ggcatcggtc atcccgctcg 2727001 ccatgcagta tcaaaagcgg tgtctccacg tttgctgcgt attttaaagg agaccggtcc 2727061 cagagctttt ctgtgtcctc aaacatgtca tgctcaagct gccagtctgt aaagaaatag 2727121 ccgatatcac tgacgccgtg aaagctgatc caatttgata tcgagcgctg ggtaacggca 2727181 gctttaaagc ggttcgtctg cccgacgatc cagttggtca taaaacctcc gtagcttccg 2727241 cccgtgacac cgagccgctt aggatcaata tgcggatctc gtttgatagc ctcatccaca 2727301 gcctgcatca catcgtcata atcctttccc ccataatctc ctctgaccgc attcacaaat 2727361 tcctgcccgt agccgtggct tcctctcgga ttgatataaa cgaccgcgta tcctttcgcc 2727421 gccagcacct gaaactcatg aaaatatgta tgtccgtaca tcatatgcgg accgccgtgt 2727481 atgttaagaa taagtggata tgttgtctca ccttccattt gtgcaggcct catcagccag 2727541 ccgttcacca tcacgccgtc ttctgtagca tattgaatct cttcaggtat tgatatcgta 2727601 tgctccctga caaacttgtc attcgcgcca gtcagctgtt tctcttcctg tccaagcggg 2727661 atactgtaaa gctcactcgg tctgtccggc tttgtcacac tggcaataaa gtgctgttca 2727721 tcaggtgaaa gagaaaagct attgatgtac tctttttcca gacgaatcgg atacacaagg 2727781 ccttcaatcg aaatataata gatgcccgta ctgccttgat ctgtgccgat gacataaaac 2727841 ccttggctgt cctttgtcca aatcgggcgc tgttcagcac caccgatcaa tgaatctcca 2727901 atcagcgcat ccgctaaatg aacgtccagc atctcagtaa gacatgtgag gcggccttgt 2727961 tcgatatcat agagccacgc ctttgagagc gtagcattct tatattcctt ttcatttcca 2728021 agcaaagcaa gataccttcc gtctggtgaa aatgagcttg atccgaatga gccgcgatga 2728081 ggtgtaacct gcttaagatc tccagactcc agtgacatta tgtaaacatc atgcggcttg 2728141 ctggcatcat ctgtttcagt taaattagct gagaaaacaa gccatttgcc gtcaggagaa 2728201 aaagcaggat caccatgatc agctttgtga cttgtcagct ctttcatctc acccgacttt 2728261 acgctgacaa gcacaagctg ggcatacgca cctctcgtca gccctttgcc gtcccgtttg 2728321 taggagaggc cttgcacttc aacaggttca tagctgtcct gctctgtttt ttctcggtca 2728381 tcaatgcttt ccccctctcc caaactgaca gtgaccagaa tcgattcacc gtccggggac 2728441 catagcggct ttgacacgcc atatgggata tcagtcagtt ttcttgcttc tccgccttca 2728501 gtgctcatga tataaagctg tgccgcatcg ccttctcgat cagaaataaa ggcaagcgtg 2728561 cgcccgtccg gagaccatct tgggtcggtg cttcgctttt ctccatgtgt ccaaggaaca 2728621 gatcctcccg ttttcgtttc atagatccat atatttgatg tatacgaatc tttctcttga 2728681 tttacttgtg attttacata tgcggcacgg gtaccgtctg gggcgtattg aggatcggtc 2728741 acagagacaa tcgctgtgat gtcgtctgcg gttatcagct ttttcatatt catctcctcc 2728801 tttttacatg tatttcgttt ttctaaataa aaactccttt atctccagca aaaaaaagcg 2728861 ccctccgctg acgctgagga acgcttggca tgatctatac actttttact tgatataaag 2728921 gatttcgctc tattatactt ccctctttcg gaacggtcaa agcgtctact tcacaatgag 2728981 ggaaatgaag cgcgagctgt tcttttagct cttctccctt tcctttttcg gtcatgacga 2729041 gaatcgttgg gcctgctccg ctgagagccg ttccatatgc gcccttcatc tcggcgacgt 2729101 gctctacttt tgacagctca ggcacaagca tcgcccggta cggctgatgg aacatatcct 2729161 tcttcatgat tttcccgaca agcggccaat ccttggacat gatcgcagca atgaggatat 2729221 tgctgacagc acttgctttt acggcatcgg catatggaaa ctccttcgga agcacgtctc 2729281 tcgcgtctct tgtcagcact tcataaaaag gaatgacaac gactacgtca atgtcagcat 2729341 tcgggacgcg gatcatttgg gtctcgtcat cctcatgcag gccgatcaca agtccgccga 2729401 cgagagaagc gccagcattg tccgggtgtc cttcttctag actcgctaaa tgcagcttgt 2729461 ccgcttcaga cagctttaag ccgcataatt catcagccag ttcaatggcc gctacaatcg 2729521 ctgcggcgct gctgccaagg ccgcgtgcaa gcgggatgtc gctccacacc ttcacatgga 2729581 caggaggcat ttcttttccg tacaaatctg cggtccgttt agccacttgg tagatcaggt 2729641 tatctgtacc cgccggaatt ccggcgactg tttctgtttc agcctcaaaa gaccatttgt 2729701 cgctttcaaa gacggtcagc ttcaaatatc tgctgagcgc cattccgact gaatcaaagc 2729761 cggggcctag gttagctgtg cttccgggaa cagtgacaga gaacagcatg tcggcttcgt 2729821 tcatacacgg gccgctcctt ttacatattc aaggatgctg tcttcatcag tcggcaatgt 2729881 gacaggcttg atttctgaaa tgtcgaccgc tgtgttcgga tctttcagtc cgtttcctgt 2729941 taacacagct acgaccttgc tgcctttcgg aatttctccg gatttcacct gtttcagcac 2730001 tcctgcgata gacgcgcaag aacctggttc tgcaaacacg ccttctacac gggcgatcag 2730061 ctgatatgcg tgaaggattt catcatcagt gacttcgtca attttcccat tggattcctc 2730121 ggctgccttt acagctttgt cccagcttgc cgggtttccg atacgaatgg ctgtcgctat 2730181 tgtttccgga ttttcaatca cttcattgcg cacgattgcc gccgcaccct cagcttcaaa 2730241 gccgcgcatt ttcggaaggc ctgtgccgtt tttctcatga tattccttga agcccttcca 2730301 gtacgcagtg atgtttccag catttccgac cgggatcgct aaaacatcag gcgcttcccc 2730361 cagctgttcg cacacttcga aggcagcagt tttttggcct tcaatgcggt aagggttgac 2730421 tgagttgaca agggcaatcg gtgatttctc acagatggaa cggacaattt taagcgcatc 2730481 gtcaaagttt ccgtcaattg cgataatctc ggctccgtac atgacagctt gagcgagttt 2730541 tccaaatgca atttttccgt tcgggatgat gacaatgcat ttcatgttag cacgggctgc 2730601 atatgctgcc gcagcagcgg aagtgttacc tgttgacgcg cacataatcg tgtcattgcc 2730661 ttcttctttt gcctttgcca cagccataac cattccgcga tctttaaatg atcccgtagg 2730721 attgacgcct tccgttttga catgaagctc aattccgagc tgctcagaca gcttcggcag 2730781 gtgaataaga ggtgtgtttc cttcatgtaa agttagcgcc ggtgtttgat ctgttacagg 2730841 taaaaattct ttatattgat ggataagtcc tttccacatt agctccaacc gttcccttct 2730901 acacgatatg tgcttttgac ttcttgaacg acttccaaat catttaggtt ttgcaggata 2730961 tcactgaaat cagcttctga tgtatgatgt gtgacaatta cgatttcagc taactcatca 2731021 tggcctttaa ttggcagctg aaggattttt tcaaagctca cgccccgctc tgagaacaca 2731081 gatgtaattt tcgagaatga accaacctca tcttttacat gaattcttaa aaactgctgt 2731141 gcataaatgt cagacggcga tttcatgttt ttctcatatt gcggtccgac aaagctgttg 2731201 ccggttacac ctaggcgcat atttttcatg acagcgacga ggtcagaaac aacggatgtc 2731261 gctgtcggca tgcttccggc tcccggcccg tagaacatcg tctcaccgac agcctcgccg 2731321 tatacataaa cagcgttaaa ctcattatga acagcagaaa gcggatgatg gtcaggaagc 2731381 agtgtcggct gtacgctgac ctcgattttg ctgccgtcac gctgagcaat cccgatcagc 2731441 ttcattgtat agccgaggcg tttgctgaag ctgatgtcct cgtctgtaat ttgggagatc 2731501 ccctttactt tgacgtcttc cagatccacg ttcatcgaga agccgaggcg cgccaatatc 2731561 gccattttcc gtgcggcgtc aagcccttcc acgtcagaag tcggatcagc ttcggcaaaa 2731621 ccgagatcct gcgcttcctt gagcacttcc tcgtatgggc ttttctcttt gatcattttg 2731681 gttaagataa agtttgttgt gccgttcaca attcccatca tttttgtaat tcgatctgat 2731741 gagaggcctt cctctaacgt gcgcagaatc ggaatcccgc cggcaacact ggcttcaaag 2731801 tagatatcgc atccattttc cttcgcttcg gcaagcagct cggagccgta cacagccatt 2731861 aagtccttgt ttgctgtgac aacatgcttt ttcgatctca gcgcgtcgac caaatattgt 2731921 tttgtctgtt caacgccgcc gatcacctcg atgacgacat caacatctgg atcatcaatg 2731981 acatcataca cttctgtcgt gagcacttcc ttcggcaaat ctacttctct ctttttctct 2732041 aaatctttta caagcacttt ttttatcgta accggacagc cgacctgatg cataagctta 2732101 tcctgatggt cttgaataat tttaacgaca ccgcttccga cggtacctaa acctaaaagc 2732161 cctacacgaa tcgctttcaa aaaaactcca cctttctttt gattgtcctc ttggaaaaga 2732221 caattgttaa ctcaacacag acatataagt tacaaacatt atataagccc gctcctgttt 2732281 tgacaagaca tcattaggct gaattttgcg aatgtaaacg cttaacgcat tgatatgaca 2732341 agattcttta ttttctaatt atttttgtca gattttctcc tcaccttgag ctgcctttgc 2732401 cgagccagct gacgcgtgga acaaacagct tctgcgcccg catattcatg aattcctgcg 2732461 ctgtattgag aaattgttca taacgcccac agtcattaag aatgaagtca agctgttctt 2732521 caaaataatg cttttctgat tctgatgaca tgtaatagct ttctacgatt tcaaaataat 2732581 gaagcgggaa aagcagacgg ctgtataaaa ggcgtttcga aaatgaagac agcggtgtga 2732641 cttgctcgta ttcctgtaaa aagagaaagc cctgctgatt aaaatcttgt ctgtgatgca 2732701 aaaacgtatg cctcatatat tcagccaaat cacgggaagc gtggtcaaac acccaatccg 2732761 ccggaatcct gatcaatgat tccggtgacc atgtatgcct ttccatccgc tgatggcata 2732821 tcgttcctga atcagcggct tggggcttgt catccagctc agtgtccact aaatattgta 2732881 tcgcgttttc tgacagtcct aaataatatg gaaatgattc gatcattttt ttatcgaatg 2732941 gctcatgcgg aggggtctga acctttctct gccaaaatgc ttccagctga tcaattcgtt 2733001 ttccccacag atccttccac tggccgattc ttccggccgc cttcacctca tatggatatc 2733061 ctcggccttt tcggtgaaat tccgcaagct ccgctccaat ggagaacgcc ctgtttgaat 2733121 aagggggggc cgccttcagc agagcgtacg tttttccctc atgttcaaat gtcagttcac 2733181 cttcttttgt aaagataaaa accgaaacgt atgggtcact ttgttcttgt aaatactgac 2733241 tcatgtaata aagctccgcc agctctgttt ctgagaattg ggaaacgggg acaatcagaa 2733301 agtatgaatt aggcgtctga aagcattgat atgtgtgctg gtacatggaa agctgcctga 2733361 tgtgaatgcc gtatttttct tttattgtac ctttcaccat gatcacctgc ctgttgaatt 2733421 agggctcatc acatcgtagt catacacagc cggaattatg aatacatatt ttaatccgaa 2733481 gaaggcgcaa gaaaaagtcg taaacttctc aagcattttg tataaactag taaaaaagat 2733541 tgggtgaagc tgatgtcaga aaacgaacaa ttcagtcaga tggaagctaa agcaagagca 2733601 cggatgaagg agcgcggcgt tgaggtatca gacattgccg agcttgtctt ttttctgcag 2733661 aaaaaatatc atccggattt aaccattgat gaatgcacgc tgaacgtcaa tcgtgttctc 2733721 gcaaaacgcg aggtgcaaaa cgcgatttta acgggcattg aattggatgt tcttgctgag 2733781 cagaaaaaat tgtctgaacc gctgcaaacg atgctggaaa tagatgaaag cctatatgga 2733841 gtagatgaag ttctggcatt ttccattgtg aacatttacg gatcgatcgg gtttacgaac 2733901 tacggttaca tcgacaaaga aaaacccgga atccttaaac gattgaatga taaatcaacc 2733961 ggtgaatgcc ataccttttt agatgacatc gtcggagcga tttccgccgc ggcttcaagc 2734021 agacttgctc accgcgcgcg gcatacagaa taagggcacc cttttagggc gccctttttt 2734081 caaatgtatg gaatccattc agtcagagag tcaatggcgt gagtcggttt ttccatatcg 2734141 tctgtcatat gttctctttt cgttacgcct gtgtgaacga gcagcgtatc catacccgcg 2734201 ttaatgccgg ccataatatc agtggcgtag ttgtcgccga ccatgagtgt ttcagacaca 2734261 tctgtgccga gaacgcgcat cgcctgctcc ataataattg attccggctt gccgataaat 2734321 acaggctgta cacctgtaga tacggttaac accgatgtca gtgagccgtt tcccggcagg 2734381 agccctcttt cagtcggaat cgcaatatct ccgttagtgg aaataaagcg ggcgccattt 2734441 ctgattgcca ggcagccaac agcaaatttt tcgtatgtaa tggaacggtc gatgccaaca 2734501 acgacaaaat ccgcgttttc tccgccaaat gtcaggccgt tttcttcaat cgcctggcgg 2734561 attccttcct ccccaatcac atacacagac gcgtcttttt tctgctgtgc aatgtgctgg 2734621 gcagttgcca tgctggtcgt gaagacctgc tcttctgttg ccggaatatc aaaagacacg 2734681 agcttgtccg ctacctgctt cggtgtgcgc gaagagttgt ttgtcacgaa aagataagga 2734741 acgccgcgat ctttcagcgt tctgacaaat tcacacgcct cctcgatttt ttccgtgcca 2734801 ttgtacatcg ttccgtctaa atcaattaaa taccctttat atgttttcat atccaacact 2734861 cctgtggctt tccagttgtt atttaaacgc ggaaacaggt cctagctctg tttccaaata 2734921 gcttctgatc cgtttcggga agtcctgaag agctgtttga tgcgccttga tcagcctgta 2734981 aagctcgccg ctgtcagcga gcagatactg ttgaaccaac gttttgcggt aggcgatcaa 2735041 ttttttgagc tcatcaccct ctttttccgt gacaactttc tcatcaacaa gtatatccat 2735101 aatgtcgtca tagctgcccg ggtcccgcat aataaagccg tcaatcatgt cattgcctgt 2735161 atccaaaatg cattcgatta acagatggcc tatacgctga agtgccaatt ccccgatttc 2735221 agactgccag tctgtttgtg agtcaaatag cgccagctgg tgctcgaaga accctagtgt 2735281 tttttcgatt ttgcttctgt caacaaaata catgacagca tcccctttgt gtatatttat 2735341 tttctgatcc gtttcaagac aaaatacgca cagccgaaat tgcagtattc gtaaatatat 2735401 tcatctaatg tgctgatttt cgtttcgaag gttgcctttt gattctggtc gtcaaagaag 2735461 cccttgagcc ttaactgacc gtatccccag tctcccacaa tataatcgta tttatttaat 2735521 atatcggagt agcgggcttt aaaagcctct tcgttgaagc cgtctttgaa attgtgcacc 2735581 aattcaaatt cggcattttg aataagaatc atgatctcac ctcttttttc actcattcct 2735641 atcataattc attgccccgt ccccatcaat tgctaaagaa taaatcatgc gatttggcta 2735701 ccctacacat gaggagggat tgataaatga aacgaaccgc tgtcagcctc tgcctgctga 2735761 ccggactatt atccgggtgc ggaggcgcag gattggataa tgcccaaaat gtccggaatc 2735821 agacgcagaa tcaaaccaaa cccattcatg tgtcggaccg caacgaggct tttaacaggc 2735881 ataatgagaa cgaacaattt ggctatgtcc gctatcaaaa agaacaattt gacggagaac 2735941 agcagaaaac gccggtgatg aaccgggaag aaaccgctca catgatatca agtttaacgg 2736001 ttcagctccc ccatattcaa gatgctgcga cattggtgac tgaccgagaa gcgcttgtcg 2736061 tatacaaaac cgattctaaa aaccgggagc tgaccgccga tcaggtgaaa aaaacagcgg 2736121 cttctgtgat accgcgatac tatcacgtgt atatttccga taatccaaac catatgcaat 2736181 ccgtcgaaaa ttacagcaat ctcggctctg gttcaaggga tattagagag atcatgtcgg 2736241 ggacgattca agaaatgaaa acctccccgc aaggaagccc tgtctcagag aatgaaaatg 2736301 ccaatggaga aacgcgtcag gacatgaaaa tcgataggaa tgacaaaaac gccagatgat 2736361 ctggcgtttt ggcattatgc ttgtgcttga cgctttttag atgcttcgtt tacttgttca 2736421 tccgcatggt aagaggaacg gacaagcgga ccggcttcac aatggctgaa gcctttttgc 2736481 atcgcgattt cttttaattc tgcaaattca tcaggatggt agtatttttg gactttcaag 2736541 tgtttcttcg tcggctgcag atattggccg attgccataa tatccacgtt gttcgccaag 2736601 aggtcgtcca ttacttcaat aatctcttct tttgtttcgc cgagtccgat catgatactt 2736661 gattttgtcg gaatgtcagg ctgcatttcc ttcgcacggc gcaaaaattc caatgaacgg 2736721 tcgtacgtcg cacgcgcgcg gactcttggc gtcaggcggc gaaccgtttc gatattgtga 2736781 ttcaggatgt ctgggcgtgt atccatcaag gtttttaggt tatcgtagtt tccgcccata 2736841 tcagacggca gcacctcaat tgttgtgaac gggctttttc tgcggatcgc acggacagtt 2736901 tccgcgaaaa tgcctgcccc gccatctttc tgatcgtcac gcgcaacagc cgtaatgacc 2736961 gcgtgtttca aattcataag cgcgactgaa tccgctacgc gttccggctc ttgcagatca 2737021 agctcagttg gaaggcctgt tttgacagca cagaaacggc atgctcttgt acaaacagaa 2737081 cctaaaatca taaatgtcgc tgtacgtctg accgcccagc attcatgaat attcggacac 2737141 tttgcttctt cgcatacggt atgcaggttg ttttcccgca tgagtttttt gagccctgta 2737201 tagttttcat ttgtatttaa tttaatttta agccattcgg gctttctgag gtgttcgtct 2737261 ttctttgcca attcccatca tctccaatat ccaatatact caatttctga cacgaaacat 2737321 tctgaaaacg agaaaggtgc aggttttagt tctgcaacaa aaataatgtt tttctaacta 2737381 aagaaagtct tttctttaga cactttaaca taggaaaaat ttctcgacaa gggaagatga 2737441 ttactgacat ttttaagccg ggttgccgca aactatgtgt attcaatatg aaaggagatt 2737501 attttgtgaa agttttgtta tccgctcttc ttctcctttt gtttgcattt gagccttctg 2737561 cgtctggaaa aaaactttca gatccagtgc tgtcgaaacg gatggaatta tatcataaaa 2737621 tcgaagctgt gacgcagatc ccttggtatg cgctcgccgc tgttgatcaa tacgaagaaa 2737681 acgtgcggag caaccggaaa gatctgcctg aaaaggcggg aatcatcagc atctatatac 2737741 ccgatgatat ctggagcggg cctgaaaacc cgaatccgaa agacgatgcg ccgttaagca 2737801 ttaaagtgtt tgacggaatc ggaatggatg gcgatggaga cgggaaagcc gaggtcagca 2737861 acgatgaaga tatcttgtat acgttcagcc aatacttact gtcgtatggc acagatgaag 2737921 acaacatccg gatcgggctt tggaattatt accggcgtga tcagacagtg gggattatat 2737981 ctgaattcat gaagctgttt aaagcctacg gccatattga tctgggcgag catgcattcc 2738041 cgcttccgat cagaaccgat tacagctacc gaagcacgtg gggagatgcc cgcggcttcg 2738101 gtggaaggcg gattcatgaa ggtacggata tctttgccca ttacggcctt cctgtcaaat 2738161 ccacatgtta cggcgtagtt gaaatgaagg gctggaaccg cttcggagga tggagaatcg 2738221 gcatcaggga cattaacaat acgtatcatt attttgccca tctcaatggg tttgccaaag 2738281 ggattaaaac aggacaaatc gttgagcctg gccaagtgat cggatcagtc ggcagctccg 2738341 gatacggccc gccgggaacc gccgggaagt tcccgccgca tctgcactat ggcatgtaca 2738401 aagataacgg aagaaccgaa tggtcatttg atccataccc gcatttgagg gcgtgggagc 2738461 gatatgaata ccaaaaaaag aagtaacaaa aagccgcctc ttcaacaggc ggcttatttg 2738521 ctgctttttt ctttttttga atcggcaccg ttttctttgc tgctcggaag ctggacagaa 2738581 ggcgtgacac ccgagccgcc gcttccatta taaaactgcg gcacttcgcc ctgcactgct 2738641 ttaatcgata caggaacatt atttgtgacg acagcggttt tgctggcaaa tggaatgatg 2738701 accttcactt taatttcgac aaagatgctg atatcaataa gtgcgttatt tatgccatac 2738761 ggcttgattt tggttttgac atctgtaaaa gcgtcaccga ttaaattgaa ccggaccggg 2738821 attttcggcc cgaggtttcc aagaaggctg ttgccggtta cctgtcccag cggaatgttg 2738881 atcataatgt tttcactggc gccgctgtgt ccggtatggg tttccatctc tttcaaatga 2738941 gcctgaagct gctttgtcac ttttgttttc acactgttta caacctgtgt attaaaatcg 2739001 attgtcgtta agtttccgtt ttcatcagaa ttcatttgaa acatatcttt catattttca 2739061 ctgtcagaca tatagtcctc aatcgaatcc tggatcacct ctgtcgctat acgcttcgtt 2739121 tccatctcgc cgatgtccat taaaacaggt ttgatcgagc cattgatcat ccaaaggctg 2739181 accgttgttg acaggataaa aaagacaacg gacaggagca tcacgtaacg gaaaggcaaa 2739241 ggtcctctct tgcgaaaagg gccgcgatat cttggcaaga aaatcccccc ttacatatca 2739301 caatgtatgc ttgtaagagg ggacatagta atagccgggg ccaatttatt ttatttcatc 2739361 atttttaaaa gcgcttctct gccgctcatg ccgactttga tgccaagatc ttccgcagcg 2739421 tacgtgacgg attctaaagg tgcgtctaac agctggtcaa tggtgcggac accaactgcg 2739481 cgtcccgcca cgatgccgcg ctcctttaat ttttcattca gcagcgccac atcaagcgcg 2739541 ccgcacataa tgtatccgtg atcattggcg acggccataa aattcgtttt gggaagcttt 2739601 actgtcacag ctgtaaaagg ctgtccttct atcatgatcg gtgtcaggtt taccacgtca 2739661 accactccct tcattcatca ctttatgatg aagggcacag cttgttgtgg gctgactgcc 2739721 ttattgtgca agcttccaag caagcagatc ccgcaaaaat tccggcataa aatattcttt 2739781 ttctgcagcg tcgcgaatca acggaaacag tttgccgagc gtaaacatat caagcaccgc 2739841 aacggagtat tgtttatgtt tttcaatatc ttccccgttc agtgtgatcc gagtgacgtg 2739901 ggtgatcccg tcatcgagcc gtttcgtttc tacctcaacg ccggcataca ccattttccc 2739961 catcacttct ccgcggaagc cgagtccttt gatccggagc tgctccattt gttcggaagc 2740021 ggcatggaca atggtttcct tcagttcttc tcccgtcagg cggacagcca ccgggttgat 2740081 cggatgcgga cagatgcggt gcagatccag ctttgtcaca ggacctgctt ttagcggacc 2740141 gagaatgaca cctgaattga ccatactgat gtccgtctcg caccattcct ttaaggcgta 2740201 tgccaaaagc aaaggcagct ctgattcttc aaaccacttc acctcagcat cttgtgcaag 2740261 ctctgcaacg gcatcggaca gtttctcctc ggcttcacgt tctttttcat tgagaaacgc 2740321 tttagtttct gcggattctc ctgtccattc cgccatgttc tgcacagaag ccgttttgct 2740381 gttgatgctt cgctgtacgc tgtccaccgt gatttctaca cagccgacat aatgcccgta 2740441 tttctcggcg ctggccagca gtaccccatt aaccacttgt ccatcttcga gcaaatgatg 2740501 ggtatgtgat tcgaggatta catcaatctc aggcaccgct tcagccactg cttgatcatc 2740561 aagaatgcct aaatgtgaca gcagaacgat aatatcagcc tgccctttca cttccagaat 2740621 ggtttccttt atgctttcaa gggcatccgt aactgtccat cccagcttgt catatacagg 2740681 ataatacggc acagttacac ctaagaaagc aatggacata ccgtttttca atgatttgat 2740741 atggtaaggc accgcccagg acggacggtt tccattttta tcaaacaggt tagagacgat 2740801 gacaggaaat tcagcatgat catataaggc agcaagctct tcatgcggaa gcgtaatccc 2740861 ttcgttattg ccgatcgccg ctccatcaat gtgaaggcgg tttaagagat cgacattcgc 2740921 ttttccgaat gtcgcctctg tcacgaattg aaaacgatca agatgatcgc caatatcaaa 2740981 aacgagcgtc tcttcgccgt ctgactgatg ctcttttctt ttctgctcga tataatctac 2741041 aattttcggc cagttttcaa aatggctgtg caaatcattt gtatgatata agcggagctt 2741101 ctccttcata atatctctcc ctaatcgttc agctgaaaat gccttcataa atgagctggc 2741161 agccgatcaa aatcaatacg atccgcatga tcataacgat cgttttcgtc tgcatttttc 2741221 tgttgatggc ggcgccaagc tttccgccga accaagcgcc gggcacaagc gcgagggcgt 2741281 acagccaatt gacgtgcccg gaaatcatat gtgaaacaga ccctgtcata gaagacagga 2741341 aaataataaa catggacgtt gccaccgcaa ccttcggcgg aaacagaaat aacagcatca 2741401 tcgccggaac catcagtgat ccgccgccta taccgaaaag tccgcctaaa aaaccgacaa 2741461 caaaggcaat ggcaataccg acagaggcct gatatgagta cgtataaggc tcaccggcat 2741521 catcctgaaa tgtccggata attcctttgt gcgctttgtt gattggccgg gctttcgctt 2741581 tcagcattaa ggataatgaa atcagaatca taaaaatgcc aaaccaaacg gaaaacgagt 2741641 ttgaattgaa cagctttgac acgtaagccc cgatcatgct gccgggaccc gaaccgataa 2741701 agaaaatgag tccgctctta taatcaactg ttttatattt aatataagcc aaagttgaag 2741761 aaaggcccgt aaaaataatg accaaaagcg aagttccaat cgcaacctgc ggcgtcacat 2741821 cctgaaacag ctgcgtcact gtgcttaaaa acatcagaga tggcacaatg acaattccgc 2741881 cgccaagccc gatcagactt cctaccgtac ctgcgattaa tcccagtacg accaaaatca 2741941 caaacgacat caatcaaaac ctcttttcta aaataaatcg agctgtctcg gagcaagtcc 2742001 gctgtactcg atatcaagca gttcaagcat ctgcttgcca ttatccgcag cgtcaccgcc 2742061 ggaattgttg ttgaacagga caaaaacatc cttacattgc tgctgcaatt cattcaggtg 2742121 ctttttccaa tcctccagct cctgttggtt gtagcggtat aagtacctga cctcccgcca 2742181 gtttttcccg ccatcaggct tcatccagcc ctgcttgttg cgtccgtgaa acctgacgag 2742241 cgttttgttt tcatcggtcg cgcgcaacac ggtcggaacg ctgccttctc cgatttgcgg 2742301 ttcatcacag acactgtgaa tccagccttc cgctttcata aatgaaagcg tctgctcata 2742361 aaatggcggc gagaaccagg aacggtttct gaattcaagc gcgcaaggaa tatctcccat 2742421 ttggtgctta caccatctca aataggcgac attctccttc ttgcagtcaa accacggcgg 2742481 aaattgaaac agcaccatgg cgagcttatt gctatgtaaa tatggcgtta aagacacctt 2742541 aaacgcatca aacatctcct cttttgagtc aaagggaatt tcgccgcgct gatgccctgt 2742601 catgccctga tatgctttca cgataaattg gaaggtttcg ggcgtttcct tcacccactt 2742661 ttcattattg cgcgccggct gaatcgcgta aaagctcgcg tctaattcca cgatcggaaa 2742721 atgggaggaa taggcctgca attttttctg gctggccgtt ttcggcggat agatgctgtc 2742781 atgatccccc catcccgtca gtccgatata aatcacactc attcacctct cttccagttt 2742841 atcacacgtg ttttcaggtt tcctcggaaa tgctgttcat atggcgggaa aatgcctcac 2742901 gcaaatgctg atattgttcc tcattcgtat ctaaaaacgc ctcttctctt gaggaaggaa 2742961 tgtgctgata ttcaataggc gcctgaaact gctcactcgt aaaatcgtac accacaccat 2743021 tgatgctgtt ataaaaatgc cagctctcat cgactcttgt tttgaaaatc gtgccgccga 2743081 aatggtcttg aatcaccaat gccgtcacgc cgcattggcc gcatgacggg cattcttccg 2743141 tccatttaga gctcgaatgg cgcgaccagg attgcttaag tatgtatttg acatgctcca 2743201 ttgcctccgc ctcctttaaa aaaagatacc acgttgatga gattttaaaa actagaacgg 2743261 aggaaatcaa aaaacccggc ggtaaaatcc gccgggctta cgaaggaacg accagagctc 2743321 cgtcaatttc agtgactttt tccccatcat tgtacacgca ccggcctttg ctgtaagtgg 2743381 ccgaaatgct gcagggaaat gtatgtcctt cgtaaatgct ttttttatgc tttgcaaaca 2743441 tcgattctct tgtaacagtg tacggctcca tgctgacgag cacgaaatct gcatcacacc 2743501 ccgcctcaag ccgccctttt ttctgaaggc cgaatcgttt tgcaggggcc gccgctgtcc 2743561 attctgcgat ggtttcaaat ggaatctgat gctcaagcgc cagttccagc attcctaata 2743621 aagtgaactg cccgccgctg attccgcccc atgataaaaa catgttatcc tcccgcttca 2743681 aggatggacg gcaaggggaa tggtctgagg aaaccatgtc aatgtccccg gcaatgagcg 2743741 tctcgatcag cgtctctttt gattgccgtg accggagcgg aggcgcgcat tttgcgacag 2743801 agcccctttg ccgtaaatcg tcatggctga acaagacata atgcggacat gtttcaaccg 2743861 aaacatcaag accttcctgt ttcgcctctc tgatcagccg gaccgctttc gccgtgctga 2743921 tatggacaaa atgaaccgga cagcctgtca ccttcgcata ctgaatcgtg cgatacaccg 2743981 cttcaacttc tgcttcctcc gggcgggagg cggcgtacgc atccgcatcc acctttcctt 2744041 tattggccaa aaccatctgc aagtagcttg tgatcgcgtc gctttccgcg tggagagcga 2744101 ggatttttcc tgcagccgcg atttctgcca tgcctttgag caatgtccgt tcatcaacag 2744161 agcggaactc atcagtgcct gactttgata aaaacgcttt aaacccgatc gctcccgctt 2744221 cagccatcgg acggatgtcc tcgatatggc ctggcacaag gccgccccat agcgcaaaat 2744281 ccacggcaga tttttgcctg cctagctcag cttttgcgag aagatgctct gccgtcacgg 2744341 ttgatggaat acagttgagc ggcatatcaa aataggtagt gcaaccgcct gcggccatca 2744401 tttgagaacc tgtttcaaac ccctcccaat cctccctgcc cggttcatta aaatgaacat 2744461 ggcaatctat cacaccagga aacacgtatt tcccgtctgc ctggatgatt tccgtcccgc 2744521 ttgcttcaat gtcagaacct atctcggcaa tgacaccgtt ttgaactaca atatcagctt 2744581 ctataacgcc atctggcgta actgccttcg caccttttat caccatatcg taagccatat 2744641 tgatcccccc atgtcaggat gacgattttc catgtcagtt tatgtaacac aaccagttct 2744701 attttcaaca gtttactgct actatgatcg tattacatca gcaaaaccgc tagaattcct 2744761 attgaaaatt attcacctta accaatgttt ttatagaaaa ggagaatgcg ctatgaatat 2744821 tcttgatgtg atgaaaatac cggcttttga aaacgccaat ttaatcgctg gaaaagcagg 2744881 aggggaaaga gaggttcagc atgtcaatat gatggacgct ccggatatcg tagacttttt 2744941 gcataagaat gaattgctcg tcaccaccgc ctatcacctg aaggatcacc cgcatcaatt 2745001 atctgaactg attcggcaaa tggcaaaacg cggctgcgcg ggcctcggca ttaaaacaaa 2745061 gcgctatctg gaagatatcc cgaaggaaat catcgaactg gccgattcat atgcgtttcc 2745121 gatcattgag cttccggaac acatccgact cggcgatatt gtgaatgcca cactcagcca 2745181 tattctcgat atgcgttcta acgagctgca gcaagccatt tacgcgcaca aaaaattcac 2745241 aaaccacatt atgagcggca aggggctgca atccctcctc aaaaaggtgt cagacatcct 2745301 tcagcttccc gtgctgctgc ttgaccagca tgccaaaatg ctgtctgcgt ctcatcagat 2745361 ttcagttgag accgaaaagc tgaaaggcac cctgaatacc gtatccgggc catttttcac 2745421 ttgtttctct acaatctcag atcagaaaac atattctgtc ctgcctattt ataatcacga 2745481 aaaaaactgc ggctacctgc tgatacccga catggtgcag gcaggcgaca aaggattgat 2745541 cctcacgatt gaacaagcgg ccaacgtcat ttcctttgaa ctgctgaagg aaaatgcgct 2745601 gaagcagttc agccggcggg cccgcaatga gtttttcaac aattttattg agcggacctt 2745661 ttcttcagat gacgaaatca aaaaccgggc gaaagaattc aagctgcgct gggatcaaaa 2745721 atacatgtgc atcgccggca aactcgatcg caatgacgaa tcaatcagct ttacagaaaa 2745781 tcagctcgct tccgacagcg tattcgaatt tcttgaaggt gaattatcag ccttcccgtt 2745841 tccacctcac ttctttatga aaggaaatgt cggcattatt ctaatcgagg cgacagacag 2745901 ctggagtgaa atgcacgcct cggtgatcag ctttttagaa cagtttcaaa cacaggtcag 2745961 cgctcaattt aaacgaaccg tgtcctttgg catcagcaat atctgccaaa agctcattga 2746021 tgttcccgac gctttcacag aagcttctga tgctctgcaa tcggggcatt tgtcaagaag 2746081 caccgcattt atccaggtgt atcacgccaa agatgtgcct gagcttctgc gcttgctccc 2746141 agttgaggat ttgaagaaat tttacaactc cacgcttcag agcctcgctg aaaaacagca 2746201 ggaggatcaa agcctgcttc atacgctttc cgtctattta gagacacact gccaaatttc 2746261 agagacggca aagcgtctgt acgttcatcg caatacggtc atataccgcc ttgaaaaatg 2746321 cgaagagctt ctggggaaaa gcttaaaaga tcctgaaaca acgatgcgtt tgcggcttgc 2746381 attacgtatg cagcggctga tcagctaaag tttgttacat tttcttacaa aacgaatcgt 2746441 ttttcgtcac tttcagcaat cacacctgtc tttttcagct actgtatcca atgacacccc 2746501 tcgaccggaa cgatattatg ttactaaagt tcacatacag ggagggacta tagtgaaaaa 2746561 aagatcgttt aaggtgttta cacttagcct gcagcatgtg ctcgccatgt atgcaggtgc 2746621 gattttggtg cccctgcttg tcggcagggc gctgaatgta acaactgaac agctgtccta 2746681 cctattggcg attgacctgt taacatgcgg cgtcgctacg cttttgcaaa ccttgcgcgg 2746741 aacatacatc ggcatcgggc ttcccgtcat gcttggcagt tcatttgtgg ccgtcacccc 2746801 aatgattgca atcggcagca attacggcat tcacgcgatt tatggttcca tcattgcggc 2746861 cggtgtgttc atctttttgt ttgcgcgttt tttcggcaag ctgactgtgt tatttcctcc 2746921 tgtcgtaaca ggtaccgttg tgaccttgat cggcctttca cttgttccga caggtgtgaa 2746981 aaatatggct ggcggcgaaa aaataaacgg cagcgccaac cccgaatacg gttcgctcga 2747041 aaaccttctt ctctctgtcg gtgtccttgt tctgatctta gtcctcaacc gctttctcaa 2747101 aggatttgcc cgaacactgt ccgttctgat cggcatcgcc gccggaacag cggcagcagc 2747161 gatcatgggc aaagtcagct tttcttctgt tacagaagca ccgttcttcc aaatcccgaa 2747221 gcctttttac ttcggagccc ctgcgtttga aatcggtccg atcttaacga tgctgatcgt 2747281 cggaatcgtc attattgtgg aatcaaccgg cgttttttac gcaatcggaa agatatgcgg 2747341 cagaccttta actgacaaag atctcgtcaa aggctatcga gcggaaggaa tcgccattct 2747401 catcggcggg ctgttcaatg cctttcctta taataccttt gcgcaaaacg ccggcttatt 2747461 gcagctgacc aaagtgaaaa caagaaacat cgtcgttacc gcaggctgta tccttgtctg 2747521 tctcggactg attccgaaga ttgccgccct tgcatctgcc gttcctgctg ctgtacttgg 2747581 cggcgcgacc gtcgtcatgt tcggcatggt gattgcctcc ggcgtcaaaa tgctcagcac 2747641 agcggatctc aaaaatcaat accacctcct gaccatcgca tgctcaatcg cactcggcat 2747701 cggcgccagc acggcccccg ggatttttgc tgaattcccc gctccgatcc ggattctggt 2747761 cagtgacggc accatcaccg gaagcctaac cgccatcttt ttgaatctat ttttcagctt 2747821 gcgcgacaaa aaagaattaa cagcacagca aacagaactt ccggtattag aacatacact 2747881 cgcattagaa aaagaggtgt aaaaaagatg aaggaacagc acaatgcctt acagctaatg 2747941 atgctggggc ttcagcacat gcttgccatg tatgcgggag ccattctcgt tccgttgatc 2748001 gtcggagcag cgatcgggct gaatgcgggg cagctgacgt atttaatcgc gattgatttg 2748061 tttatgtgcg gggcggcaac tcttttgcag ctctggagaa accgatattt cggcatcggc 2748121 cttcccgttg tgctcggatg cacgtttacc gcagtcggcc cgatgatttc catcggaagc 2748181 acttacggtg tcccagcgat atatggtgcc attatcgccg caggactgat tgtcgtctta 2748241 gccgcgggct tcttcgggaa gcttgtccgt ttttttccgc ctgtcgtaac cggatcagtc 2748301 gtcatgatca tcggcatcag cctgattcca acggcaatga ataacctggc cggaggtgaa 2748361 ggaagcaaag aattcggctc actcgacaac gtgctcctcg ggtttggcgt cacagctttt 2748421 atcttattgc tgttttattt ctttaaaggc tttatccgct ccatagcgat tttactcggt 2748481 cttatcgcag gaacagcggc tgcatatttc atgggaaagg tcgatttttc tgaggttttg 2748541 gaggcgtctt ggcttcatgt tccgtctctg ttttatttcg gaccgccaac ctttgagctg 2748601 ccggctgttg tcacgatgct tctcgttgca attgtcagcc tcgttgaatc gacaggcgtt 2748661 tattttgccc tcgctgatat cacaaaccgc aggctgtcgg agaaggatct ggaaaaaggc 2748721 taccgggcag aaggccttgc gattttgctg ggcggcttat ttaacgcgtt tccctataca 2748781 gctttctcgc agaatgtcgg catcgttcag ctctcaaaga tgaaaagtgt caacgtcatc 2748841 gccatcacag gaatcatact ggtcgcgatc gggctggttc caaaagcagc ggccctgaca 2748901 acagtgatcc ccaccccagt tctcggcggc gcaatgatcg tcatgttcgg catggtcatt 2748961 tcttacggga tcaaaatgct atccagcgtt gaccttgatt cgcaaggcaa cctgctgatt 2749021 atcgcctctt ccgtcagctt ggggcttggc gctacaacag ttcccgcgtt gttttcatct 2749081 ctttcgggcg cggcctctgt cttggcagga agcggaattg tgatcggcag tttgacggcc 2749141 attgcactgc acgctttttt tcaaaccaaa cagccgaata gcgcagacat aaaaacgtaa 2749201 aggaagatgc caatgttcac aatggatgac ctgaaccaaa tggacacaca aacactgaca 2749261 gacacacttg gctctatttt tgaacactct tcatggattg cggagagatc cgcagcacta 2749321 cggccgtttt cgtccctttc tgatcttcac cgcaaaatga ctggcattgt aaaagctgcg 2749381 gatcgcgaga cacagcttga tttaatcaaa aagcatcccc ggctcggaac aaagaaaaca 2749441 atgagcgatg actcggtacg agagcagcag aacgcagggc tcggcaaatt agaacagcag 2749501 gaatacgagg agtttctcat gctgaatgaa cactattatg atcgcttcgg ctttcctttt 2749561 attttagcgg tgaagggaaa gacgaaacag gacattcacc aagccctgct ggcaaggctt 2749621 gagagcgaac gagaaacgga gttccagcag gcccttatag aaatttaccg aatcgcccgc 2749681 tttcgtctgg ctgacatcat cactgaaaaa ggagagacgc aaatgaaaag aaccatgtct 2749741 tatggcaaag gaaatgtatt tgcataccga acgtatttaa aaccgctcac tggagtgaag 2749801 caaatcccgg aatcatcttt tgccggaaga gataataccg ttgtcggcgt tgatgtgaca 2749861 tgcgaaattg gcggagaagc cttcctgcca tcatttacag acggagacaa cactctcgtc 2749921 gtggcaacgg attcaatgaa aaactttatc cagcgccatc tcgcatccta tgaaggaacg 2749981 acaaccgagg ggttcctaca ctatgtagct caccgatttt tagataccta ttctcatatg 2750041 gacacgatca ctctgactgg cgaagacatt ccgtttgaag caatgcctgc atacgaggag 2750101 aaagagctca gcacaagccg cctcgtcttc agaagatcgc gtaatgaacg aagccgctct 2750161 gtgctgaaag cagaacgaag cgggaatacc ataacgatta cagagcaata cagcgaaatc 2750221 atggatcttc agctcgtcaa ggtgagcggc aactccttcg tcggcttcat ccgggacgaa 2750281 tatacgactc tcccggaaga cggcaaccgc ccgctgtttg tctatttaaa catcagctgg 2750341 caatatgaaa atacaaatga ctcatacgct tctgatccag cacgctacgt tgcggctgaa 2750401 caagtccgcg acttagcgag caccgttttt cacgagctcg aaaccccttc aatccaaaac 2750461 ctaatctatc atatcggctg cagaatatta gcgaggttcc cgcagctcac tgatgtcagc 2750521 ttccaatctc aaaatcacac gtgggatacg gttgtcgaag aaatcccggg ctcaaaagga 2750581 aaagtctaca ccgaaccgcg cccgccatac ggtttccaac attttaccgt gacaagagaa 2750641 gacgccgaga aagaaaaaca gaaagccgct gaaaaatgtc ggagcctgaa agcctgatgg 2750701 gaaaactgac aacccatatt ttagatttaa cctgcggcaa accagcggcg aacgtaaaaa 2750761 ttggattgaa gcggctgggc gaaagtatta tgaaagaggt atacactaac aatgacggca 2750821 gggtcgatgt ccctctgctg gctggtgaag agctgatgtc aggagagtat gtgatggaat 2750881 ttcatgcagg agactatttt gcgagtaaaa acatgaacgc agccgatcag ccgtttttaa 2750941 ccatcgtcac cgtccgtttt cagctagcag atccagatgc acattatcat atcccgctct 2751001 tgctgtcgcc gtttggttat caggtgtata gggggagtta agaaggaagc ccgcctcacc 2751061 ggcgggcttc tttttgcact tcaattaact tttgatccta ggacagtact tgaagtgatc 2751121 cccacactta gtgaaacaac agctagaata aacattcacc tatatttttc aggataattg 2751181 cctacgagaa aaataccctg tagtcctttc atttataaat cgaggtttca aactaataag 2751241 tcagctctta gcagccgagc tcccttctcc aatcctataa acagaccgcg ttttttctcg 2751301 aaaaaatact ctgaagacaa ttgctgcgtt tttaatagtt ttgataacgc gttctctctt 2751361 acacctttag acaaaatatt cattttttct tttttagact taaatctatg tcgaaaataa 2751421 tcgttggcat atcttatcct atctccacta aaggaggtga cattatggga ttctacaatt 2751481 ctggtggata cagtggaaac tctggttact caaacggttt cgggagctcc ttcgctttga 2751541 tcgtggtgct attcattttg ttgatcattg ttggagcagc tatctttaat tattaagttt 2751601 aactttcctt gcctccgccg tatccaacac ctccctgtcc gacagacgcc ataagaagtt 2751661 tttatggcgt ctttgctatg tgttcactaa tctttttgta atccagaagc tgtcaagttc 2751721 tacgagattt atcgtgtgtt ttcccacaac gcttctgcgt cttgatcgcg ctgtctgact 2751781 gaggctaaaa aagtccggct tttaaaagcc ggactcccgt ctacccccgt tcaactctct 2751841 tctaatcctg caagctgacc gcataatccc gccatacccg gtacaccggc acaaattccc 2751901 cgccagccct tcttctatat ctttgtcaga aggttgaggg gtttcccgaa acaatgcttt 2751961 aagcgcaatg atcattcccg gcgtacagta gccgcattgg aagccgcctt cttccaggaa 2752021 agcggtttga cacatatcca gctcttcttt ttgaagcccc tcgatggttg tgatggaatg 2752081 gccgtctgct tgataggcca tcgtcatgca cgcattggcc agttttccgt cgattaaaat 2752141 agagcaggct ccgcagcggc cgattccgca ggacaccttt gtcccggtca gctgaaattc 2752201 ctttctaagc aggtcactca gatgtgtcgt aggaacggca gcaacctccc acgcctgacc 2752261 attcacggtc atccggaact gttccttttt tacaggaaat ggcccggcct cttttatgtc 2752321 cattgcttca gcccctttct gtcgatcgct tcaagcaact cttctcttga aattggcagc 2752381 ttgtttatcc agcatccgac cgcatcatgt actgccttta caatcgccgg agtgatggcg 2752441 attgttccga tttcaccaac accgcgcggt ccatatacgt ctcccttcat taagtcttct 2752501 attgcaatca gcttcatgtc aggaacatct ttgattccgg gaatcaaata gtgatcgaga 2752561 ttttccgcag cataacggcc atccgtcatt ttcgcttcct ccatcagtgt gtagccgagt 2752621 gccatggcag cgccgccttc aatttgacct cgatatccct gcggactgac aaccggacct 2752681 gccgcaatag cgtgctcaca atctatcaat ttgacatcgc ctgttaacag atctacctcc 2752741 acctcaacgg cagccgctcc aaatgagtag aggaaatggc cgcccaccac aggatcaggc 2752801 gttgttggaa agtcaaaggc cgtttcctct gccaaagggc ctttttcagc cagctcctta 2752861 tacgtcacca cgagcgcctt tgtgtttttg tcacgcaagc ctgcagcgcc gggaataaga 2752921 ttttccgctg aacagccgct ccattctgcc gcccgttttt tcaactgagc tagaaacggc 2752981 ttcttcaaac gctggatcgc gtgccacacc atgcttgtgc cgcgggatgc tgtggaggag 2753041 cctgacttcg gcacttttgc ggtatcccca ataacaatgg aaatatcctc tgcggcacaa 2753101 cccagctcct ccatgacaat ctgttcaatc gctgctagaa tcccctgtcc gcattcttca 2753161 aatccaaacg aagcagtgat tttgccttca ctcgaaagag acaaacggcc tcctgccgca 2753221 tccattcggc caaaccccag cccgccgccg tgcattgtaa ttgccgctcc cgtgcctctt 2753281 tgcagatacc cgcagttccg gcttgttttt ttaagaatgg gagatttaga tatggcattc 2753341 aacacctgtg ccgctccgtc agttggtgca attcgatgct caagcggccc caagtcatgc 2753401 ggttttctga tattttttct tctcagctcg agcgggtcga tgccaagcat gccgctgaga 2753461 cgatcgagat gggtttcgag tgcaaatgtg atttggttgc cgccaaagcc ccgaaattcc 2753521 cccgccaccc cgttgttcgt aaatactgat attccttcag tccggatatt cggaatacgg 2753581 tacggccccg cggcatgctc gacagaaaaa tcaagaacag ccggtccgag cgtagcgtaa 2753641 gcgcctgtgt ccgccacaat tttcacgtcg tgcgccaata gatttcccga atgatctgca 2753701 cccgttttta tcgtaatctt catcggatgg cgcttaatgc cagaacgtac agattccttt 2753761 cgtgtctgat gaattttgac agggcgtccg cttttcaggg ccaaaagcgc agcatacggc 2753821 tgaatattca gctcatcctt ccctccgaac gagccgccca tcggacttga cacaattctg 2753881 atcttctctt caggaatatc aaaaatacgg gcaagctgga aacggtcttt atagccgtgc 2753941 tgggttcctg catacatcgt aaaacccccg tcgtcttccg gaacggctac acctccctcc 2754001 gtttccatat acgtatgcat ctgccgcggc agctcatagg tttcttcaaa gactgtgtca 2754061 gatgcttgaa acccttcttc cacatcaccg tttgaaaaaa atgcgcggtg caggatattc 2754121 ccgtcctcat gcagtctttg cgcattcggc cgaagcgctt tttctggtga atccatgact 2754181 tccagctctt tatactcaac ttgaatcagc tccagcgccg cttccgcgat ttcttccgtt 2754241 tccgcagcaa ctgcggcgat cgcatccccg acataccgca ccctgtcctc acataaaacc 2754301 ggctgatcag ggatgacaat gccaaatcgg tttaagccgg gaacgtcttt atgtgtgacg 2754361 acggcctgca cgccttccat tttctcagct tttatggtgc aaaccgacac aatctctgca 2754421 tgaggataag cacttctcag caccttgcca tacagcattc ctggaaagct gagatcggtc 2754481 atatatttca attcccctgt gaccttaccc cttccatccg gcctgactct tgacggtttg 2754541 ttgatgatca tttattcccc tccctcagcc atcagctctg ccatgatgac gttggcagcg 2754601 gctttttttc tgtatgccgc tgacataaaa acatctgagg aaaacggcag ctcatggata 2754661 agtgttttgt acagctcatg cgggtcccac cctggtgcca tccatttcgc ttcgctgtcc 2754721 aataatctcc taggagtgat atcggcatgg ccagcggcga ggcgaatgct gccgtctttc 2754781 aaaaaacgtc cagctgcaac agcagccgct ccggtaaaag cctggcgcct tccaagcttg 2754841 tgataaaata cacgctctcc ctccgcccgc gggatgatga cacgcgtgac gatagccgtt 2754901 ctaaagtctt cctcactgag ccaagcgcca agcggcagcc tgattagctc cttttgatat 2754961 acgataagct cagcaccaag cacaagcaga agcggaatga aatcaccgat tttactcgct 2755021 atgttgccgc caatcgtggc acggctgcga atccccggtg cagcgacagc ggaagcagcg 2755081 tcactgaaac agctaagcgc tctcttaatc aaagggttct ttctgcattc attcagtgat 2755141 gtgagccccc cgatcgacac gtgggtgtca ctggtgctga tccctcgcat ttcgtcaatc 2755201 ccttcaaggc tgacaaggtg ctgtttcggt agagttcctt tgtcccactg aagctgaagg 2755261 agcgtgcttc ccgatgcggc acacacatcc ggagcaagct tctctaaaag cgaataggcc 2755321 tcatcaagcg ctgccggtct ccataattga atattcatcc ttgcttttgt cacttggccg 2755381 ttcaagacat cgccctcctt accatgtcat attcctcggg tgtatcaata tcgtccaact 2755441 caccgctatc ctttgcctcc aaaaccgctc ctgctccaag ctgtccgctt ttcaggagcc 2755501 tgcgagcccc ttcatctccc tttaatccct ttacataagg aaaacatgtc gacgagaagt 2755561 agattggcgg ggtgaacgcc cctaaaaacg atgacacggc aaatgactca ggagccagag 2755621 ccacaagggc attgagatga tcgacggaaa gctgaggctg gtcggctaac aaaatgacaa 2755681 tgccgtccgc ccccatgctt tctgcttttc tcaccccgct gctgactgaa tgcccctgac 2755741 ccttttctgc gtcttggcaa acgtgcaggc tccagcgttt ttgaaaaggc ggagcgtgat 2755801 acggcgctcc tatccactca agggaggcat gttctgtccg ctcgacgacc agcacgtgat 2755861 caaggcggga cgacagagca gttttcaagg aaagtgagcc tatgttttct ccttttagcg 2755921 gcaaagccag cttgttttgt cccattcttc tgcttttgcc ggcagcgaga aacacgccga 2755981 tcagataggg gcttctcata caaccgccac ccgttttctt gtttgaatga tttctgcaac 2756041 tacacttacc gcaatttcct cgggaccttc cgcaccgatt ttcagcccga ccggactgta 2756101 aaagtgagac ggaggatgtt ttccgctcag cagccgtttc gtgcggtttg ccgaacccaa 2756161 cagtccaata taatggaggt tttgagaaaa taagaagttg atgatcgttt gatcgtgctg 2756221 ataatgatgg gttgccacaa cagctgcatc atgcggaaaa aattgaaatt cgctaagcat 2756281 ttgttccgga aaagcggtga tcagctgatc cgcttttgga aaaagagagg atgtacaata 2756341 agcgggccgc caatccgtca cgataacaga aaaccctgtg tcagccgcca aattggccag 2756401 cggtacatta tccggtcccg ccccaaacag aatgagacgc ggcttcggtt caattcgctg 2756461 aataaacatg ttagtggttt gatcgaaatg cggtaaatga agcgttgaaa cagtacgttg 2756521 aatatcttgc agaggcgcgt ccggccagtt cccaaaatgt ccgttctccg tcagaaataa 2756581 ataatgggag gattcaatct ttataacgga agtgacagct ttgcctgaat gaaggcagtc 2756641 cctcactttc tcatagtgcc gccttttttc ctgagtgatt cgctctgcat gaacatgaat 2756701 aatgccattg cacccggctc ccatgcccca agaaagatcg tcctccgacc gcatgtcgta 2756761 gggaatcagc gttgatgtga gctgatcgcc cagcgcactg attctttgga atacatcttc 2756821 ttccacacac ccgccgctca gcaagccaat ccgtctgcct tttttcttaa agagcataga 2756881 ggcgcctgct tttcgatacg cggagccttc aacttgaaca attgtcgcca gtacagcctc 2756941 ctcctggtct tccaggagcg catctaacat cgtgtgaaaa ttccccaatg ccgcatcctc 2757001 ctctcgaaaa ttgccgtgag aaacaactag ttcagcgtga ttttataggt aacttgtata 2757061 aagaatagac gatggaagaa aaaatgactc atgatttgtc agaaaatgaa acacatagaa 2757121 agaggatttg taaaaagagt caaacgaaga aaatcagatt ggagaaaaca cgaaatcata 2757181 tcgttaaaaa gcttgcggag ttccgcaagc ttttctttac accgctgcct ggcggccagc 2757241 gttttcatac acatccagcg ctgcttggag cgcttttcct gcttcgattc ctgcgttatg 2757301 tctgagaagc acagcctcta acccggcaag cacgaatagc acgttttctt ttctgcagct 2757361 gtaccccatc gtgccgatcc tccagatctt ccctgcaagc gggccgaatg agctggcgat 2757421 ttcaatgccg aattgtgcca gcagcatgtc acggacagac tcgccgtcaa tgccgccggg 2757481 aatttcgaca caggtgacaa caggcatttt gcagctgtca tctccaaaca atcttagccc 2757541 cattgccttt atccctgctg ctaatgcggc ttcatggtgc cgatgccgct cgaaacgcgt 2757601 ctcaagacct tcttcaagca ccagtctgac tccctcacgt aaggcgtaca gcatcgtcgt 2757661 cgcttctgta tgatgattga gccgtctttc gctccaataa tcctcaagct ggctcaaatc 2757721 aaagtagttg cttgtaattg gccgatttcc cgaaagtgct gccctgtcag cttgtgtcgc 2757781 aatcccgcgt tccacctttt tgcgagctgc aatcacgtcc gccacccgct cattatatgt 2757841 aatcggcgcc attcctgaag gcacagacaa acatttttgc gttccgccga tggcagcgtc 2757901 aatcttccat tcatcgactt taacctcgca gcccccaatc gttgcgactg catcgacgat 2757961 aaacaatgca tcctcggtgc ggcaggcttc gccgatggct ttcagcgggt gaatccgtcc 2758021 tgtcgatgtt tctccatgca ccatggccac aattttcggc ttcacttttt ttatctcccg 2758081 tatgatgtcc tccgggtcaa aaaccgttcc ccattcgcac tccagcatat gaacatttgc 2758141 cccatatcgc tcggcgattt cagtcagcaa ataaccgaaa cggccgtaaa tgggaatgag 2758201 cacatcatct tccggctcta tcacactagc cagcactgct tcaattcccg cccgtgaagt 2758261 gccgtcaatc gggtatgccc agcggttttt tgtttggaac agctcccgaa gcatctccat 2758321 cgtttcattc ataatacctg taaacgccgg atcaaattgg ccgacaaccg gggtgctcat 2758381 tactcttaat acacgcggat caacctcaac aggccccggt gtcataatcg ttcttaacgg 2758441 ggtgcataat tctcttctgc ctgacacagc cattcctcct ttatcagtaa gccagtttgt 2758501 ataataaatc agtcagtgcg cggacgccga tctcaagctg tctggctgac gtatattcct 2758561 tcggtgagtg gctgacgccg cctcggctcg gcacaaacag catacaagca ggatagcgcc 2758621 ttccgatcat ttgcgcgtca tgccctgctc cgctcaccat ttcctcacag ctgaagccgt 2758681 tttctaatgc tgtttcaaaa gccgcagcct tcagcctttc gtccatcggc acaggctcta 2758741 tccgcatata ttcatcaatc acagcgcgaa ttcctttttg taggcaaatg ccgttgatca 2758801 aagcaaccat gtcttgatga aactgttcca gcacatgctg atgctgatgg cgaatatcga 2758861 ttgaaaactg gacgcggccc ggtatgacat tggctacatt gggctctgcc gttatttttc 2758921 cgcatgtcag acggagctca tccggcagct catccgaccg cagcagcagc tcatgaatga 2758981 tacggctgct ggctgcgagc gggtccttgc gccatttcat ggaggtggtt cctgcgtgat 2759041 tgcattctcc ttcgagcgtg acgagatatc gtctctgccc cgcaatactt gtcacgatgc 2759101 cgagatcccg gcctgacatt tccaacgtct tcccctgttc aatatgcagc tcaacaaacg 2759161 cgctgatatc tgtcctatat gctgactgaa acacaccttt gccaaaaccg ctctcatgca 2759221 tcgctgtttg gagggagact cccgactcgt ctcttggctc ttttgcatct tgttctgaaa 2759281 aaacacccgt catattcccc gacccccaat aggtcattgg aaaacggctg ccttcctcct 2759341 cacataagga gaccgcctcg agcgtttttt ttggcgctcc gtatgtttcc ttgagctgct 2759401 ttaacgcgag cattgccgcc agaacgccat aggcgccgtc gtattttcct ccattgatga 2759461 cagtatcgat atgtgaaccg gttacaatga cttcatccgg agactgggtg cccgaaagcc 2759521 ttccaaacac attgccgaca tcgtcgaatc ttgtttcaag cccgaaagaa gacatttccg 2759581 ttttcacagc aagctgtgcg tccatccact cttttgtgta taaaagcctc gttacgccgc 2759641 catccgcaga cgcaccgtat tgggcgagcc attcaatata atctgtgatg ctgtttttta 2759701 ctgaaagctt ctgcttttcc atgtactccc ccctctggcc gctatggtga cttcattata 2759761 gaaggagcaa catgatagtt cattgacaga ttaaccaaaa aaacgtttat tttttagcca 2759821 cagtatccat ccagcaacca gatacaccct acatgtcaca actattttga tgtaaaggtc 2759881 aaaagaaaac acggtaagga agagagccag caagagcgaa agagagggtc aaaatgcctt 2759941 tcatatgaac aagctaagct ggagaggcga tgttcgcgga acggatgaaa acagaaatgc 2760001 cggcagcccg caaaaacagg acctaaagat atggaaacag gagatttccg cctcctccaa 2760061 agggactaat ttacaatttt aatgaaaaat atacaaaatg acacttctat cctttatttc 2760121 aattttagat aatagatatg atctgataaa aggagggcaa gtgatgacaa aaaaagcatg 2760181 gtttctgccg ctcgtctgtg tattactgat ttccggatgg cttgcgccag cagcttcagc 2760241 aagcgcgcaa accacattaa gccttaatga ccgattggcg tcttcccctt caggaacggg 2760301 aagccttctc tcattagccg cccccgctgc accctatgct gacacagata cctattatga 2760361 aggggctgaa ggtaaaacag gagactcgct aaaaagcacc ctgcaccgta ttatcagcgg 2760421 acacacgatg ctgtcctaca gcgaagtgtg gaacgcgctg aaagaaacgg atgaagaccc 2760481 aagaaatccg aataacgtca tcctgctcta tacgaatgaa tcgcgttcca aaaacctgaa 2760541 cggcggcaat gtcggcgatt ggaaccgcga gcatgtctgg gcgaaatccc atggcgattt 2760601 tggtacgagc aagggacctg gtactgatat tcatcatttg cgcccggctg atgttcaagt 2760661 taacagcgcc agaggaaata tggattttga caatggcggc actgaatatg cgaaggcacc 2760721 cggaaattat tatgacggcg attcatggga gccccgcgat gatgtgaaag gcgatgttgc 2760781 ccgcatgctg ttttacatgg ctgtccgtta cgagggtgat gacggctatc ctgatcttga 2760841 gcttaatgat aagacaggca acggctcagc tccttatcat ggcaaacaat ctgtcctgct 2760901 cgaatggaat aagcaggatc cggttgacga ccgcgagcgg aaaagaaatg aaatcattta 2760961 tgaaaaatat cagcacaacc gcaatccatt tatcgaccac cctgaatggg cggatgagat 2761021 ttggccgtaa gaaaaaggtg ctccttttga ggagcacctt tttctaatac acagcctctt 2761081 ccgtttccgc atcgaaaaag acgacgtggt ccattttcac tgagagctgg attgaatcgc 2761141 ctgcatcgat tcgcgtgttt ccgtccaggc ggaccttgag ccgctcgtcc ccagccatga 2761201 catgcactat gagctccgag cccagatttt cattcacttc cacgttcgct tgaaacactg 2761261 aatcaaacaa ctggtcattt cctgtcattt gtgtgatgtg ctccggccgt acaccggcaa 2761321 tcatctgttc tccggcatat cccttttcct tcagccgctt tgctttttct tcaggaatat 2761381 gaagccggat cgaagaattt gtgaaaaaca gctcgccatg ctgctgttct atgatgcctt 2761441 tcaaaaagtt cattccggga gagccaatga agcctgcgac aaacaaattg gccgggtaat 2761501 gataaatgtc atgaggtttc gccacttgct gaatttcccc ttcattcatg acgacaatcc 2761561 gatctcccat tgtcattgct tcggtctggt catgcgtgac ataaatgatc gttgcctcta 2761621 atcgctggtg cagcttgctg atttctgtcc gcatcgtcac tcttagtttt gcatccagat 2761681 tagaaagcgg ctcgtccatt aaaaagacct tcggctccct cacaatcgac ctgccaagcg 2761741 ccaccctttg ccgctgcccg ccggagagcg ccttcggttt tctcttcagc aaatgttcaa 2761801 tttctaaaat tctggctgcc gcatgaaccc gctcggcaat ttcctgtttc gccatctttc 2761861 tgagctttaa tccaaacgcc atattatcaa aaaccgtcat atgcggataa agcgcatagt 2761921 tctggaatac catcgcaata tcacgttctt tcggcggaag atcattgacc cgctccccat 2761981 caataagaag atttccttca gaaatgcttt ctaatccagc caccatccgc agcgttgttg 2762041 attttccgca tcctgacggc cccaccagca ccaaaagctc cttatccttt acatctaaat 2762101 caaagtcctt cacggttaat tgtgagtgat atgatttttt gacgtgttca aatgttaatg 2762161 aagccatcag aaaagtcccc ctatcttttg acccgttatt tcgtcactgg aaacaacttg 2762221 gtctttctgt tatttttaga gtaatcgatt cccatttttg ctatatttct aaaataaaaa 2762281 atgtaaattt gtattataac gtcataatac attataatat aaataatagg ttaaaaggag 2762341 gctacccttt gttaaacaac ggaagttcta cacctttata cattcagcta aaacaaatca 2762401 tcactgatga catcaaaaag ggcgtgtatt ccccaaccgc caagctgcct accgaaaacg 2762461 agctttgcac caagtataac gtcagccgca tcaccgtcag gaaagccatt ctcgatttag 2762521 tcgaagaagg ctatctgatc aggcagcagg gaaagggaac gttcgttaaa agccctaaat 2762581 taaaacgaga gctgatcgct gtaaacggct actcggaatt tatggaatca accggcaaaa 2762641 aaccgaagca tcatgtgctg tcccatgaca tcattccagc gtcaaaaccc atcgccgaaa 2762701 agcttcaaat ccaacccgag agccctgtgg ttgaattaaa acggatttta tataatgatg 2762761 atcagcctct cacctttgaa gtgacgcatt atccgcttga tttgtttccc ggcattgata 2762821 cctttattgc tgacggcgtc tccatgcatg atattttgaa acagcaatac aaagttgtac 2762881 ccacgcacaa tacgaagcta ttaaacgttg tatatgccca acaggaggaa agcaaatacc 2762941 tggattgtga tatcggggat gcgctgtttg aaattgataa aacggctttt acatcaaacg 2763001 accagccaat ctattgctca ttgtttttga tgcacacaaa ccgtgtcact tttaccatca 2763061 acagccccta cacataacag gcataaaaaa cgagacactg cttatagtat tctcgttttt 2763121 tcactgcttc ccccgtcctc caagcgataa ggatagccat agccgaaagc tccgtacaca 2763181 ccgcaagttt tcgcagccgt ttcagcagcc tggcgcaaag catacgttat atcctgcttc 2763241 acgcaaaagg cagtcaaaaa gcctgctata aaagaatctc ccgctccaag tgtatctatt 2763301 atatcagctt ccacaatcgg ctgatgatag actcgatcac ccgcagacag gattgctcct 2763361 tggccccctc gggtcataca aaccattttg gctccgtacc catgagctgt tttggcaagc 2763421 tcaccgcatt ccgactcact caaatcgctt cctgaaaaaa acgcatacgt cacataagga 2763481 cagaccctcc tcaaataatc atcctcccga ttggttgaaa aatcaaatga gaccgggacc 2763541 agcccgcaca gctgcggaag atcgttctca agcctgctgt acacgctcgt atgcagcaga 2763601 tcatgcccgc tgataaaaga tacatctttc tcctgaaacg cgaggcgaag ccgggactga 2763661 atgccgcctt tatttgatct gacaaaaatg cggtccccct gttcatcaag ggtgacaatc 2763721 gccatcccgt tttctccgtg cgcctggcgg atataatctg cattgacctg ctccagcttg 2763781 agaacgttca acagatgcgc cgcggcttcg tcattgccga cgattccgat ataggaagac 2763841 tcatgcccga gccgcttggc aagcacagca acgtttaagg catttcctcc cgggtaaaat 2763901 gtttcttgat cctggtagta atctacaaca ttatctccaa ccgcaatcaa tttcatagcg 2763961 cttcctcctt tatcctttta cactgccgct tgcaatcccg cggacaaaat atttctgcat 2764021 caataaaaat agaataataa tcggcgcggc tgaaatcgtt aaccccgcca gcaggacgcc 2764081 ccagtctgtc tgcagcgcgt ctctgaactg catcagcccg gctggaatgg tccgtaaatt 2764141 ctcatcatct atgaaaataa tcgcaaacat aaactcattc catgtatggt aagccgtcaa 2764201 aatgccggat gtcaccaaaa tcggcacgct cattggtaag aaaattctga aaaatactcc 2764261 aaaacttgta cacccatcca aataggccgc ctcctccaat tcttttgaaa tagaaagaaa 2764321 ataagagcgg atcaaaatga tggtgaatgg gatccgataa gccgcatacg gcaagattaa 2764381 cgcccaatac gtattgtaca ggcccagcga ctgaataata gaataaagcg gcacaagact 2764441 gacctgcggc gtcagcatca atccgccaag acatagcacc aaaaagaatc cttttccttt 2764501 aaactcaaac cgggaaaggc catacgctgc ccatgcactg ataaagacag tgatcacaca 2764561 cgtcagcgcc gtaacgatga cactgttcat aaaataagaa gaaatcccct gattccaggc 2764621 ggaaacaaaa ttttccggat gccacgaaga cggcagcgac cagctgtgct caaaaatatc 2764681 gtcagagttt ttaaaggcgc tcatcaccat ccagagaagc ggataggcaa tcgcaatcag 2764741 ataaagaaac agaaaaaccc acacagacgt ttctccgata taccattttc gtctaggctt 2764801 atctttcacc tcaatgtgct ggtcaggcac cggctccaat ctgaacgaat ctgtcttctt 2764861 ctgaggcagc atcagttact cctcctttcc ggttttaaag aacttcattt gcatgagcga 2764921 taatgcaagc gtaatgatta acacgacagt ggcaatcgct gaggcgtagc ccatcatatc 2764981 ctttgtaaag gcgcttttat ataaaaacgt gctcaagact tctgacgctt ttcccggccc 2765041 gccgcctgtc aaaatgtacg gctcattaaa gaccgtaaag gctccggtca gcgtcatgac 2765101 caccgcaaca aaagacatct ctttcgtctg gggaacagta atatgaaaaa actgctgaat 2765161 tttacccgcg ccgtcaagcc gggccgcttc atacagttca tccggtattt tttgaatcga 2765221 cacgatgtac agcatcgcaa tataaccgac agattgccac tgggacacaa aaatgacaga 2765281 aagcatagct gtgctgtcat ccccgagcca ggccctcgtc agctgatcaa gaccgatggc 2765341 ctgaagcagc tgattcaaaa gccctgtctc cggattgtaa ataaaatcaa acaaaagcgc 2765401 gatcaccgtc attgagatga caaccggcaa aaagaaaacg gtacgaaaaa acggcgacca 2765461 ttttctgacc agcttatcct caagcaccgc cgccaaaatc aaaccgccaa atacctggca 2765521 tacaattgag atcactgcat aaagcacatt attggtaagt gcctgataga agacaggatc 2765581 atgaaataat tcaacatagt tttttaagcc gataaacgtt ttttccggag aaaatgagct 2765641 ccactgaaac aggctgagga atacattctc aaaaatcggg atataaacga aaagtaaaaa 2765701 aacgagagcg ggcaccaaaa acaaataggg gattatttta ttctgattga ccaagggtat 2765761 ctcatctcct ttataaaaag aaaaggtgcg aagcttcacc ttttctttga tttattcagc 2765821 tgacgccctc acctgctttg ctgccttttg aacggctttc atcacctgct gcggtgtcat 2765881 gtcgccgcca agcatttgct ggacgcccgt taggtacgca tctgcgactt caacatcgac 2765941 atccatatca aaccatggaa ccattgattt ggcatcaaca atatgctgaa cggcttcacg 2766001 ctgaatggct gttgcatttt cttcagtagc cgtaccttgc actgcactgt atttcccgac 2766061 atctttcacg agcttttcgc ccattctttt cgacgtcaag aactgcaaaa attccatcgc 2766121 ttccttcgga tgttttgttc ttgaggagat catgaatcct tccggcgctc ccgttaacgc 2766181 ttctgaagat cctttctgcc cgctgatttc aggaaatggg aacatcccga gattaaccgg 2766241 ttcaaccagc ttgatttccg ctgtttccgc atatatcatc gccgactttc cgctcttaaa 2766301 ttgctgtctc acatattcgt ggtcgacgga gtttacatgt ttattaaagt aaggcatcag 2766361 ctcttgaagc ttttcaagtg cttttacgta gccttcatca gtaaattcac ccgttttggc 2766421 gttatagtcc ttttcccgtg ttttttcatc gaccatccgc tgattaagcg tgccgatata 2766481 gtgcgagatt gtccaagtcg cctttgttcc aaagctgatc ggtgtgtagc catgttcttt 2766541 cagctttttt gacacatcga ttaattcatc ccacgtcttc gggggatcaa gattcagctt 2766601 ttggaaaatg tctttattat agaagaatga tttagcgtcc atttgccacg gtacgccata 2766661 ttgcttgttt tcataagtaa atggtgtaat ttgcgattga acgagctgtg atgaccaatc 2766721 ggtgtcattt ttgtagtagg acgagagatc aagtgcttta ttgcctctga taaatttaaa 2766781 agcaaactca tcgctccaag agaagtaaat gtcaggaggg ctggtggttc ccagcatgac 2766841 cttaatttta tctttatagg agtcatttaa aacggcttca atttgaatgt cgatatctgg 2766901 gtgatctttt tcaaattcct taacaacctc ttcaaaataa cttttttccg gctcctttgg 2766961 ccatctgtgg aaaaatttca atgtcacctt tccgtccgct gaactgcttt ggctcgaaca 2767021 gcctgcgatg gtgagcatac tgacagctgc aatgatcaag aacaacaaca ttttcttcaa 2767081 agggttggcc tcctctggac attagactat aatgttatat aacattatag tctaatgcat 2767141 aatggttctt cattttcaga tcaatactca actttccaca tgtatcttct atgagataaa 2767201 ggatgatttc tctcctctgc cagctcgtct gcatagcttc tcagcacacg attgagaacg 2767261 agcggagcaa gatagccttt aactgaatcg tcaattgcag tgaagtcgta agatgcagca 2767321 tcaagcacag tgagcttttt gccatacttt ttcgagaagg taagcgcccg ctcttcaaga 2767381 ggtcttgttt catctaaacc gagcaggatg ataaacggca cggattcatc aataatttca 2767441 aacggtccgt gaaaatattc tccggcatga atggcgtggg aatgaatcca ttgcatttcc 2767501 atgagaatgc agatgctgta ggagtaagcg acaccgtagt ttgcaccgct tgccatggta 2767561 taaataatgc tttctttttc atgggctttt gcaaattgct tggcgttgtc agcttcctgc 2767621 ttaagggctt tttcatatac agcctgcaat tgatctaagc cttcaattgc ttgctcaaat 2767681 ttcgtattgt tttctaatac ttgcagggtt ccaaaaacga tttgatacaa aacgccatag 2767741 tttgtattga tcgcaagcgc ctcatcaccc caatcgtact gggcaacata ttgcgcttcc 2767801 tgcgctaaag gagactccgg tttaaacgtc atcgcaatcg taagtgcgcc cttgcccctt 2767861 gcaaacgcag cagctttgac tgtctccggg gtatttcccg aatgcgagca caaaataaca 2767921 agagactttt caccaagctg aacagggttg cgctgaataa attcgttggc gctgtagaga 2767981 tcggagttta ttgattttga ctctctgtca aacacatact tactcggata cataatggca 2768041 gaagaccctc cgcatgcgac aaagaataca tgatcaatgg ttttcccttt caaatcctgc 2768101 aagaaagctt gaacctcacg atttactttt gctgtggcct gactcaaatc cttcactcct 2768161 cgtttttatt atataacgtt atataacatt atatattgtt atattaaagt ccgcgggtag 2768221 gattgtcaat attattttct gaaatttctc aataatttat tcggatgaca gacaaagggt 2768281 ctatatgcga aaaaatgccc aaatcaaaag ccagaacttg acttaagctc tggcttcgct 2768341 gttcaatccg cagactgacg tcttatttaa aaaatacctt gtctatattg tacttcgagt 2768401 gctgtgtatt gatgatatat gtttcgtaaa tctctctttc cattggatca tcaactacac 2768461 atacctcaat tttataaact tcatctctgt gatgtttgat cggtgaaaca gtgtcttcga 2768521 aatgcttctt aattctctgt cttaactttc tggctttacc gacaaacagc agctcgtcat 2768581 gaatgttgta aaacataaaa atgccgcctt tgtcccttgg gatctggtga aagtcgatga 2768641 atccgtgaat cggttttatc ttcggctcgt tatcattagc tgactgctgt cgttcagtga 2768701 tggtgacatt cggtgcgggt atatcaattt ttatcaaaat cagttcacgt cctctttttc 2768761 attaaagata aatgctaaca catacagaaa agaaaagcta gaacagcttt attatatttg 2768821 tttgtcatgc tcttacttat tatgcaagtg ctccggctgg atcataagga ctaaggtcta 2768881 attctgtctg ctttccgaga actagctttg cgagctctgc acccaaaaac ggccccatcg 2768941 tcagtccaga agcacccaaa ccgtttgcag cgtacaggcc ttgaacattc ggcacggccc 2769001 ctacgaccgg cagaaatccc ggtgtaaacg gcctgaagcc cactcttgtt tcaacagcag 2769061 ccgcatcagc aagacccggt gcaacggcta acgctttgct caatacttcg tgctggcctc 2769121 cggctgtcac acgaagatca tcaagaccgg catcgttttc gtgtgtggcg ccggctacaa 2769181 ttctgccgtt atcaaacgac agaatgtact gatcactcgg cggcattaca accggccacg 2769241 atcctgtatc tgcatctgtc atttcaaaat gcataatctg cgctttttga aatgacactt 2769301 gaaaatgaat gccaagaggc ttcaatatct cattggccca tgctcccgcc gtcacaatga 2769361 ccgcgtcagc cgcaaactgc tttgtatctg tttgcacgcc ggtgactgtt ccgttttcaa 2769421 aaagcaagga cgcatttcct ttgatgaccg ttgcgccgcg tttctctgca gcgcttaaaa 2769481 gcgaccggca cagcgctctt ccgttcacac gggcggcacc gctgatatga accgattcat 2769541 agccgtcagc taaaatcgga aacagctttt tcgtttcact tgcagacaag cgggtaatgt 2769601 cgccgatttc cggcgcatcc tcccgtctct tatacgccct ttcctccatt ttatcgagtt 2769661 tagacgcgtc agtatgaatg ctgatggcac cgacacgttt gtatcctgta tccgattcac 2769721 cgtctttttc caattgatgg attaaatcct tatagtaccg cgctcccccc ttagcaagct 2769781 ggtaccaatc ctgattacgg cgctgcgaga gccaaggaca gacgatcccc gccgccgcat 2769841 cagtcgcttg tcccggctct ttccgatcaa tgacagtaac gcgagcgcct gtttttgcga 2769901 gatgataagc cgtcgacgcg cccagaatcc ctgcgccgac gatgatgtac gatttcatat 2769961 gcaaacacct tttctattat aatgtctatt cattttacca aatcaaatgc tttccttcga 2770021 ccttttgccc taatgtggaa aaaccgcgaa gttcgtccaa tctctttact ctcctatcga 2770081 atatcctgtc actatcaata gagaaaggat gataccatga gcgaaaatcg tcatgaaaat 2770141 gaagaaaaca gacgcgatgc ggcagtggca aaagtccaaa acagcggtaa tgcaaaagtc 2770201 gtggtcagcg tgaacacaga tcaggatcag gcacaggcgc agtcacaaga cggagaagac 2770261 taatgaacga aaacatcatt cctcttaaca gacatactca agagataccc actactgaat 2770321 ctgttatcaa aaacagcggc aactcagagg tccatatcga cattcacatt gatacaatgc 2770381 caattgcttt tgctatatta tgctctgcat tagccgcaaa gcagatgaca aaagaggaat 2770441 tcgatatggc ttatactcaa ttgcgagaga tgaacagaga aaataacagc agatcatctg 2770501 taaagcaaat tatcaatcaa gagacagaag aagagtaaaa aaccgcggcc cctcggccag 2770561 cggtttttct tctgcataca aaaaggacgc gactgaatcg gttacttctg tacaatttga 2770621 ataaggttac cgcatgtatc gtcgaagaca gctattgtga cttcgcccat ttttgtcggt 2770681 tccgtcgtaa acgtcacgcc tttttccttt aatcggttgt actctttttg aatatctgca 2770741 acgccaaaca ttgtggccgg gaggccttcg gagaatatct tcttttgata ctccttggcg 2770801 gcaggatgtt cattcggttc gagtaaaagc tcggttccgt cttgatcatc tggagaaaca 2770861 agcgttatcc acctgaattt ccccatggga acgtcttcct tttttataaa cccaagtttt 2770921 tctgtataaa actccagtgc catgtcttga tcttgtacaa atatactggt aacaacgatt 2770981 ttcatactgt ttttccctcc ttcgatatga atgaagcatg gtactatgct aacaatctgg 2771041 ctacaagcaa aacaacccac acatttatca gaggccctgt tctgatttta taaaattatt 2771101 ctatccatcc tttcagcaaa tttttaagcg gttcgttgtt gaatataagt actcgatatt 2771161 ttccctttcg ttttgatgtt acgagtcctg catcctccag tacagaaagg tgtttagcta 2771221 tcgcctgtcg cgtaatagaa aggtcgtact ttgtaataag acgtatcgta agttcataca 2771281 acgtcagctc gttgcgttca gataattcgt ctaatataag ccgccgagtc gaatcgccga 2771341 gtgctttgaa tatagcgtct ttgttcccat tcatatattg agtataagca acccattagt 2771401 tgcatgtcaa gtataagcaa ctgtatggtt gcgtgatata gaaactgaac ctatccggcg 2771461 caggtctgaa atattctaat cgataaggaa ttaaaaccat taaaataaca gtggatatgt 2771521 ctctgaaaaa taaaagaaga cgaacttcaa aagttcgtct tctacaatca aattcggcac 2771581 gccggccatt ttaaagttga taactatctc taaacccctt gataaacaaa ggagttttca 2771641 tcattaaccg atagaacctt ccatttcgaa cttaatcaaa cggttcattt caactgcgta 2771701 ttccatcgga agctcttttg tgaatggctc gataaagccc attacgatca tttcagttgc 2771761 ttcttcttca gaaataccgc ggctcatcaa gtagaagagc tgctcttcag atactttaga 2771821 cactttcgct tcgtgctcca atgaaatgtt atcatttaag atttcattgt aaggaattgt 2771881 gtcagaagtt gatttgttat ccataatgag cgtatcacac tcgatgttag agcgggcgcc 2771941 ttccgctttg cgtccgaagt ggacgattcc gcggtacgtt acttttccgc cctgttttga 2772001 aatcgatttt gatacgattg tagatgatgt gtttggtgca aggtgaatca ttttcgcacc 2772061 tgcatcctga tgctggcctt tacccgcaag agcgatagaa agcgtcatac cgcgcgcgcc 2772121 ttcgcctttt aggatacaag ccggatattt cattgtcagc ttagaaccga tgttgccgtc 2772181 gatccattcc attgttgcgt tttcttcaca gactgtacgc tttgttacaa ggttgtaaac 2772241 gttgttcgcc cagttttgga tcgttgtata acggcagtag ccgccttttt tcacgatgat 2772301 ctcaacgacc gcactgtgaa gtgagtttgt tgtgtaaaca ggcgcagtac agccttcaac 2772361 ataatgaacg cttgcttctt cgtcaacaat gatcagtgta cgttcgaact gacccatgtt 2772421 ctcagagttg atacggaagt aagcttgtag cggtgtttca accttcacgc ctttaggcac 2772481 gtagatgaaa gaaccgccgg accaaacagc tgagttaagc gccgcaaact tgttatcagt 2772541 cggcgggatt acttttgccc agtgctcacg gaaaatatct tcattctctt tcagcgcgct 2772601 gtcagtgtct ttaaagacga tgccttgtgc ttcaagatct tctttcatgt tgtggtatac 2772661 aacctcagat tcgtactgag cagaaacacc cgcaaggtat ttttgttcag cttcaggaat 2772721 accgagcttg tcgaatgttt gtttaatttc ttcaggaact tcatcccaag aacgctctga 2772781 acgctcagac ggttttacgt agtacgtaat ttcgtcaaag ttcagtgagt ttaaatctcc 2772841 gccccattga ggcatcggca tattgtagaa atgctcaagt gatttcaagc ggaagtcaag 2772901 catccattga ggctcttctt tcatgcgaga aatttcttct acgatttctt ttgtcaatcc 2772961 gcgctctgaa cggaaaatgg aaacgtcctt gtcgtgaaaa ccatacttgt attcaccaat 2773021 atcaggcatt tttttagcca tccattttca ctccaatcct tttaattgcc gccttcttct 2773081 ttcgcgactc ctttttcaag tgctttccat gacagggttg cacatttgat acgggcaggg 2773141 aattttgaaa cgccttgaag ggcttcaata tccccgagat ctatagaatc atcatactct 2773201 ttcccttgca tcatatccga gaaaatctta gacatggaaa gggcagtttc aatatctttc 2773261 cctttaatcg cctgagtcat catcgaagcg gatgccattg aaatggaaca gccttcccct 2773321 tcaaacttcg catcttccac gatgtctccg tcaagcttca ttgtcagtct gatgcggtcg 2773381 ccgcatgtcg gattgttcat atccacgaca atgctgtcat ttaaaacccc tttatttcgc 2773441 gggtttttgt aatgatccat aatcacctgt ctgtacaatg tatctaagtt tgcattaaaa 2773501 gacatttgta aaatactcct ttgtcttttg aagagcttcc acaagcttat caatctcttc 2773561 ctctgtatta tacagataaa agcttgctct tgcagtagca gttacatcca gccatttcat 2773621 cagcggctgc gcacaatggt ggccggctct gactgcgatt ccctccgcat caagcacagt 2773681 cgccacatcg tgcggatgaa catcatcaag gttaaatgtg acaagcccgg cacgctcttc 2773741 cggcccgtaa accgttacgc cgtcaagctg gcggaagcgt tcaagcgcat aagctgcaag 2773801 cttgtgctca tggcgggaaa tctcatcaag accgatttct tcgagaaaat caatggcggc 2773861 accgaggccg attgctcctg caataatcgg cgtacccgct tcgaatttcc acggaagctc 2773921 tttccaagtt gattcataaa gcccgacaaa gtcgatcatt tcaccgccga attcggcagg 2773981 ctccatgttt tccagcaggg ctttctttcc gtacagcaca ccaacaccgg taggtccgca 2774041 cattttatgg gaagaaagcg caaagaagtc gcaatcgaga tcctgcacgt caattttcat 2774101 gtgaggcgtg ctttgtgcac cgtccaccac aatgacagcc ccattgtcat gagcgatttt 2774161 cgccatttct ttaatcgggt tgaccgtgcc gagaacatta gatacatgag acaccgcaac 2774221 aatttttgtg ttgcttgtga ccgtttctct gacgtcttct aaagaaatcg ttccgtcttc 2774281 ctgcaacgga atatatttta atgtggcgcc agttgctttt acagcctgct gccacggaat 2774341 gatattcgca tgatgctcca tgtaggtgat gaccacttca tcaccaggtt tcaggttggc 2774401 gcgcgcatag cttaacgcca ccatattcag tgatgtggtc gtgccttttg tgaaaataat 2774461 ctcagccatt gacttcgcgt taataaactt gcggactttt tcacgcgctc cttcataacc 2774521 atctgtcgct ctggttccaa gtgtatggac gccccggtga acattggaat tgtattggtt 2774581 ataatactta tccagtgttt caatgacagc acgcggcttc tgggaagtcg ccgcgctgtc 2774641 gagataaacg agatcatgtc cgttcacttg ctgatgaagg atcgggaact gttcacgaat 2774701 atctgtgata ttcattactt cactttcctt tcgataacag aaactaattg tttcttaacg 2774761 ccttcaatcg gaagttcatt tactaccggt gcaaggaatc cgtaaatgac taagcgttct 2774821 gcttcttctt tcggaattcc gcggctcatc aggtagtaaa gctgaatagg gtccacacgg 2774881 ccgacagatg ccgcatgtcc tgcagttaca tcgtcttcgt caattaaaag aatagggttt 2774941 gcgtctccgc gtgctttttc gctaagcatc agcacgcgtg attcttgctc cgcattcgct 2775001 ttagaagcgc catgttcgat tttgccgatt ccgttaaaga tagaagaagc ggaatccttc 2775061 atcacaccgt gcttcaagat atagccttca gaagctttac cgaaatggat gatttgtgtt 2775121 gtgaagtttt ctgtttgctc tcctcttccg acaacaaccg ttttcgtatc gccgtatgtg 2775181 ccgtcaccgt aaaggtttgt tgtgttttcg gaaatcgtgt cgccatcgtt catcaggccg 2775241 agagcccact cgattttgct gtcgcgtccg cgcgcagcac cgcggcggtt cacataagtt 2775301 gtcacaccgc ttgacagatt atccaccgca ccgtatgtca cgctggcatt atcacctgtg 2775361 atgacctcac tgataatatt gaagacagcg tctttcgggt ttacagtgct gatgtagttt 2775421 tctacatatg ttacagagct gtggtcttca gccacaatca gcacgtggtt gaatagagct 2775481 gtatcattgc tttcgtggac ataaacagcc tgaaccggcg tctccacctg aacatttttc 2775541 ggaacataaa ggaatgctcc tccgttaaca agagccgcgt gaagtgcagt taacttatgt 2775601 tcgtcaacct tcacgccgtc cttcataaag tatttctcca ccaagtcgct gtgctcgcgt 2775661 gcagcagtca gaatatcagt gaagatgacg cctttgtctt tcaattcttg agaaagagaa 2775721 agatgtgccg gcgtctggtc acgctgtacg tataatgttt tatcttcgtt ttcaatgtcg 2775781 atcagcgctt ttacttcatc agtcaaatct tctaatgaag aaagcggttc gttatccact 2775841 gtatgcttcg cgaaattcgt gaagttccag tttgtgattt ttgttttgtc aggtttcggc 2775901 atcggcagat cctcagcttg ttcaagagcc tgtaagcgca ggttcttcag ccaggcaggt 2775961 tcttggtgct tttcggaaaa gcttttgaga tactcctgat ctacggatag ttttgtacct 2776021 agtgtcatat taatccccct aacgcttacg cttcttggcc aacagtttcg tcttcaatgc 2776081 caagttcttg tttgatccag tcataacctt ctgcttcaag acgctgtgca agctctgcac 2776141 cgccggattt tacaacgcgg ccttgcatca taacgtgaac aacatccgga gtgatgtagt 2776201 ttaacaggcg ctgatagtga gtgatcatca ggcagccgaa gttttcgctg cgcattttgt 2776261 tgatcccttt tgatacaact ttcaaagcgt caatatcaag gcctgagtca atttcatcaa 2776321 ggatggcgat tttcggttca atcatcatta attgaaggat ttcgttgcgt tttttctccc 2776381 cgcctgagaa gccttcgtta agatagcgct gagccatttc agggtccatt tcaaggaact 2776441 ccatgttttc gtccattttg cggatgaatt tcatgagaga aatttcatcg ccttcttctc 2776501 tgcgcgcgtt gattgctgag cgaaggaagt cggcatttgt cacaccgctg atttcacttg 2776561 ggtactgcat tgcaaggaat aagcctgcct gcgcacgctc gtccacttcc atctccagta 2776621 catctttgcc gtcaagcgtg atgctgcctt ttgttacttc atatttagga tgccccataa 2776681 tagcagctga taaagtggat ttaccagttc cgttcgggcc cattactgcg tggaattctc 2776741 caccttttat ttcaaggttt acacccttta agatctcttt cccttcgatt tcaacgtgaa 2776801 gatctttgat cgttaatgtt gaagcagcca tatctatacc tccaaaaata tataatcatt 2776861 attctcattt tattctcatt ctaattttat aacaaatgaa aagtaaatac aactttttat 2776921 cgtgccttgc acattcctca agtttaacaa agatcagcac tttattaaag cgattgaaaa 2776981 agaaaaagag tggattccca ccctttttta aaagattgat tttctcaata agctcccgca 2777041 gaaatccgct tgcttttttc ataatcaagc tctctctgcc gctctacttt cattcttgtt 2777101 tccagccggc gtccatattc ctcgtatcca attccgtgtg acagctgcat cgctttttcc 2777161 atttctgacg tataatcgag gttcagtctg tcctggctgc tgcaaataat gaatcaatcc 2777221 cttcatatat ttgcttttta ttgtaccagt gctgcgttgg atgccgcaaa aacgatttgg 2777281 cgtgaaatag cggcagatga gacgaaagca tcctttcaga acaaatgaga atggtttttc 2777341 ggaatattcc ttctcttaat gcgtggtgtt tccgaattcc tcaatgcact gttgaacgac 2777401 tgtcacgcct tggctgaaag ctgcgccgcc tccaaatgcc gctgccacac tgacggcttc 2777461 gagaatgttt tcttctgacg ctccctgatc aagacagcct tttgtatgat agatcatgca 2777521 atattcgtcc tgagcattga tggcaattcc gagggcgatc agctgttttt ctctttcagt 2777581 cagagaattc ccggcaaagc actgttcagt aaattcgtta aattttcttc ccatcagcgg 2777641 catcttttgt tcaaatgtgc ctaaaccatg tttatattgt tttaacgcgt cctgcatgct 2777701 tcctctgtct tgattcaaag aaaatccctc catctgttta acattccttt ttattatgaa 2777761 cagcttttag gaaaatacgc gaaaaaaacc ccggaattct catccggggt ttcagtctta 2777821 ttcagataca ggaagcacag ctccgtcgta ttttttctcg atgaagtctt tgatcttttt 2777881 agagtgaaga acttccatca gcgctttgat ttttgcagaa tcttcttcgc cttttcttac 2777941 tgcgatgatg ttagcgtatg ggttgttttt cgttgattct acttcaattg cgtctttttt 2778001 aggatttaat ttattttgga tcgcatagtt tacattgatg aagaccgcgt ctccttcttt 2778061 gttttcatat gcttttgccg ttaattcagg cgctactttt ttgaattcaa ggtttttcgg 2778121 gtttttctta atgtctttca atgttgcgtc aactgtttcc actttagaat caagagtgat 2778181 taatccagcg ttttcaagca ttgcaagcat acggccttgt tcagcaacgt tgtttgtcag 2778241 aatgattgtc gcaccgtctg gaaggtcttt cagtgatttg tatgttttag agtaaatacc 2778301 gaatggctct aagtgaacag cgccggcatt cacaagtttg taatctgtgt tttctttcat 2778361 ttcttgctca aggtaaggaa tgtgctggaa gtagttcgcg tccacttctt tatcagctaa 2778421 agctttattg tacattttgt aatcactaag cactttcact ttcagcgtat agcctttttc 2778481 tttcagcaat ggttcagctt cttttaaaat ttccgcatgc ggtgtttttg ttgccgcaac 2778541 gacaatttct ttcttgccgg attcagcgcc gttattcgaa ccgcaggcag ccataactcc 2778601 tgcaaataca agcagtaatg cacccaaaaa tagctttttc aatgtaaatc ctcccttatc 2778661 gtttgtctat aatatttgtt attagatcac cgatgatttg aataataaac acgatgatta 2778721 aaataaacac agtagcaacg aaggtaacat cagcgttatt agactgatat ccttctacgt 2778781 acgcaaggtt tccaaggcct cctgaaccaa tggctccggc aattgccgtt gaaccgatta 2778841 aagcgatggc tgtaaccgta atgccagaaa taagagcagg cattgattcc ggaatcagca 2778901 ctttgaaaat aatcgtagac gttttcgcgc ccattgattt agctgcttca atcacacctt 2778961 tatccacctc acgcagcgcg atttcaacaa ggcgcgcgta aaatggtgcc gagccgatta 2779021 ccagcgccgg caatgcggcg tttggcccta agatcgtgcc gactaaaaat ttcgtaaaac 2779081 ctaatagtaa aataattaaa ataaggaacg gaatcgatct gaatatgtta acaacggctg 2779141 caatcactga gttgaccgct ttattctgcc agaggcttcc tttgctcgtc agaaagagca 2779201 gcaagccgag gatgaccccg atgacaaaag caaacagtaa agaaatcagc gtcatataaa 2779261 gtgtttcata tgtcgcgttc cataattcag ttaaatcaac gttcgggaag tatttttcaa 2779321 acattcgtga tcacctctgc tttcacctgt ttgtcattaa tgaatcggat cacgttttgc 2779381 acttcttcct cgtccccgtc aatgtggatg aacagtgaac cgtaagcccc atccttcgtc 2779441 tgcgaaattt tcccttgcag aatattgacg ctgacattga agtttctgat catctctgta 2779501 atcagaggct gttcagctga ctcaccgaca aatgtgagct gaaccatttt tcctgatgct 2779561 gtatcatcaa gaaggtgctg aagcgtctct ttcgtttctt ccggctctgt cacctgttga 2779621 acaaatcgtt ttgtcatttg ttcctttgga tttttgaaga catcgagaac ctcgccttct 2779681 tcgaccacct tgccgttttc catgacggcg actctgttgc agattttgcg tatgacatgc 2779741 atttcgtgcg taatcagcac aatcgtcaaa ccgagtcttt cattaatatc ggacaataga 2779801 tccagaattg aatctgtcgt ttgcggatct aatgctgatg tcgcttcgtc acaaagaaga 2779861 accttcggat tgtttgcaag cgctctggca attccgacac gctgcttctg accgccgctc 2779921 agctgggacg gataagattt ttcttttcct tctaaaccta ccagtttaat cagttcattg 2779981 gcgcgcttga tccgctcgct ctttttcacc ccggcaattt ctaaaggaaa catgatatta 2780041 tctctgacag tccgcgacca aagcaaattg aaatgctgga aaatcatact gatctcatgg 2780101 cgtgcttttc ttaaaccgcg tccatttact tcattaatct tggttcccgc cacttccacg 2780161 gttcctgagg ttggtttctc aaggccgttc agcagacgga ttaaggaact cttaccagct 2780221 ccgctatatc ctataattcc aaaaatctca ccttttttaa tggaaagcga gacgttttgg 2780281 acagcattga catctccatg tttcgacttg taaacttttg aaacatcctg aagattgatc 2780341 aaagcaatca cctgccttaa cactattcta agaaatcttc cggttttttc tgcaaaagaa 2780401 aagcctttct gcacacttga gcagaaaggc ttatataaaa tgcctttctc tcatctttca 2780461 aagctgaacg cttcgtgtga attggcacca tttcaacagt gttgatggtt gccgggcttc 2780521 atagggcact tccctccacc tctcttgata agagaaatat atagtctttt tcgtccggaa 2780581 attcttaatg tagaatagca cggcgaatga ttaaatgtca ataaaataaa tgatgtcaac 2780641 ttttactatt ataataattt attatttttt aattttttaa aatcctctga aaaaatccat 2780701 ttgtcagcca gagaatggct tccagcttta acagggccct gaatgacccc tttactttga 2780761 ggcttccgct ctgaataagg tgctgaaggg aaatgtctcc gtgcaataaa tcaataattt 2780821 ccgtttggtt tccgtaaaag gtcaggttgg acgtttgggg cggagaaact tttttcattt 2780881 ctccctgttc gtttattgag acggttaagg cttctgcttc tccttggaag gtaatgagca 2780941 atgttgaggc attcaaaagg ggttttaaaa acagatgctg atactcatct tctaaaactt 2781001 ccgctttctc catatgtaca acctcctatt tgttggtcat acatacacat ttctctcttt 2781061 gtcgcaagaa cccctttata aaacgaacga caatttcatt ggatatgctg agaaatatgt 2781121 cataaatggg atgcggaaga tgatttttgt ttgatcagct catataaata agaaacggaa 2781181 tgaaatgcat atcctctttc gaccatcttt ccgcctttaa acagcagaaa acaagggacg 2781241 ctttcaattt gatacgcttt tgcgaatgtc ggagagtaat tgacattgtt ttgatagaag 2781301 gcgacatccg gcagcatttc tttcaccact gtcagcattt tgcttgcaag ctggcaggtg 2781361 ccgcaaaacg gagtatataa atatagaagg tacacatcat cttcaatgtg atcaagttcg 2781421 tgttcttgga gttctttcat gctatacacc tcgggacttt ctttcaagaa aaatagtatg 2781481 gacattcaga ttcgcacgca gcaatacaga agcgatatgg tgcctgggcg cagccgctac 2781541 ttccttatag gctctgtcga catggagatg gcaggcttca ttaaattcac gcttcagctg 2781601 ttttctcaat ttctcacctg attcatcagc atcaactaat atatagacgt ctttatcata 2781661 aagctcgtca gccaattcct cgagcctcag ctggctgatt gttccgtttg tgcagataat 2781721 gcgcatcggt tcattcagga cgctttcgat tttctcttta tctgatttcc cctcgacaat 2781781 cataaccttt tccagctcat ccatcttcat cttgttcacc tgccgcgtca aatttgaaat 2781841 gttcagattg taaaagaagg cagtgaaatt caccgccaac attaacacca gccgttttcg 2781901 tagtcacaat ctacatattt tgcgtcgtct ccagagacca catcggctgt cttataaaat 2781961 ttctcatttt caaaggaata accggactta agctcatatt cattcatgct tgtcatttgg 2782021 ccgatcatct cattatcatg atataacgag agccggccat tttgaaagcg gcctgtcacg 2782081 tcattggtga catcgagctt ttgtttgtcg aaagccatat tggacacctc ccataacgtt 2782141 agcgtgtcca attgctttta cggctatcct gttttagtct tcttgtgtca tctcttcgta 2782201 ttgctctgct gtcatcagtt tttcaatttc agaagcgtca gatggctcaa cgacgatcat 2782261 ccatgctttt tcgtacggag attcgttgac gaattccgga ctgtcatcaa gatcttcgtt 2782321 tacttccaca accgttccgt taatcggtgc ataaagctca gataccgttt taacggattc 2782381 aacactgccg aatggctcgt ccgctttgat ttcagcgccc acttcaggaa gttcgacaaa 2782441 cacgatgtcg cctagttcgg actgggcaaa atgcgtaatt ccgattctgg ctttttctcc 2782501 ttcaactttt acccactcgt gttctcctga gtaacgcaaa tcttttggta tgctcaattg 2782561 aatccctcca ttttttacag cactacaata agaagatacc acacttttca aaaaaaattt 2782621 acattaagcc cagttttctt caaattggtc ttctttaaat ccgacagtca ctttttcgcc 2782681 gtctgttgta agcgggcgtt taattagcat accatctgaa gccagcagtt cgagctgttc 2782741 gtcctctgac atatgataca gcttttcctt gagattgagc tcgcggtatt tcatgccgct 2782801 cgtgttgaaa aatttcttga gatccagccc gcttttttca taaagcgctt ttaattcttc 2782861 tttgcttggc ggctgctcag caatatgtat ttcgtttatt tctttcccat gctcttcaag 2782921 ccacttcttt gctttgcggc acgttccgca tttagggtac cagtaaaaag ttaacgacat 2782981 cttcttcccc ctcaataaaa taatcgaggt tattttaaca cagtttgttt taaaaaccta 2783041 aaacagtgct tcttaaaaaa gagctccgcg catgcggagc tcatggccaa tcagacagta 2783101 tatttctcag cctcaaaaat gcctgccgcc gcctcgcgtt ttttctgaat cacgttttta 2783161 ggcgttacgc gtgtcagctt gcgcagagcg gaaagcatca tgcggagtga atctccttct 2783221 tccattgcga taagggattc ctttgcatgc gcttcgattt cgttaaaggc ctcttgaacg 2783281 aaaatttctg tgtacagcac cttttgcgct gctttttcag cgccttgtgc ggcaatggcc 2783341 ttttccgttc tgagcacggc tgattccatt gcgtatacat tgctgacgat atccgctacg 2783401 ttcacgagaa tttcttgctc acgatcgatc gcttttccgt atttttgcgc ggctaggccg 2783461 gcagcaaaca acgcaatttt tttggcttgc ttgacgatat atttctcctg ctctaagacg 2783521 ccgcttccag gctcttcagg cataagcatc atgagttctt cctgcagcga ctgcgctttt 2783581 tcgaataaag gcagctcgcc tttaagcgct tttttcagga aggtgcttgg cacgattaac 2783641 cggttgattt cgtttgtgcc ttcaaaaatc cgattgatcc ttgaatccct ataggccctt 2783701 tctacttcgt attcctgcat aaagccgtag cctccatgaa tctgcacgcc ttcatcaacg 2783761 atataatcaa gcgtttcaga gccgaatacc ttattcagag agcattcgat ggcgtattcc 2783821 gcaatcgatt tggcgatttg ccggccgtcc ttgagatctt cggccgtgaa ctggctcata 2783881 ttgtcttcaa acagcccgac ggttctgtat acagagcttt ccatcgcata cagccttgag 2783941 gccattgtcc cgattttttc ctgtgtcaat gaaaaaccag caatcggcgt tttaaattgg 2784001 cggcgctgat ttgcgtatgc cgcagacagc tcgatgacgc gtttagatgc gccgattgtg 2784061 ccaaccgcca gtttgtaacg gccgatgttt aaaatattaa aggcgatgac atgccctttg 2784121 ccgatttctc cgagcaggtt ttcctttggc acttcagctt gatccagaat gagggttctt 2784181 gtcgatgatc ccttgattcc cattttcttt tcttccggtc ccgtggagac acccgggaac 2784241 tctttttcta caataaaggc tgaaaacttg tcgccgtcta ccttagcgta aactacaaat 2784301 acatcggcaa aagcagagtt ggtaatccac tgtttttccc ctgttaatac ataatgggtt 2784361 cctgcttcat tcagcacagc tgttgttttt gctccaagtg catcagaccc agagccaggc 2784421 tcagtcagag cataagcggc gatcttttcg cctgaagcga gtccaggcaa atattttttc 2784481 ttttgttctt ctgacccgaa aaagacgatc ggcaaggaac cgataccgac atgcgcgcca 2784541 taagaaagag aaaagcttcc cgcacgcgaa aatttctcag tgatgagtgc cgagctgatt 2784601 ttatcaaggc cgagcccgcc gtattcttcc ggcacatcgg cgccaagcag ccctagttcg 2784661 cccgctttct tcaacagtct gacagaatgc tcgaattgat ggttttcgat atcatctata 2784721 tgagggagaa catcttgctc gatgtaatcc tctgttgttt tcgcaatcat tttatgctcg 2784781 tcagtgaaat cctccggtgt atacatttga tcgtatgtga catcctcgat taaaaatccg 2784841 ccgccttttt gtacgtcagc cgcttttttt gccatttgtt tttccccctt tagcataatt 2784901 caaatacacc ggccgctccc attccgccgc cgatacacat ggtcacgact ccaaattgct 2784961 cgtttctccg tttcatttca tggatgagtg agagtgtaag ctttgtgccc gtacagccaa 2785021 gcgggtgtcc aagcgcgatt gcgcccccgt tgacattcac tttttcttca tcaattccca 2785081 attccctgat tacttgaatg gcctgtgagg caaaagcttc attcagttca aacaagccga 2785141 tgtcctgcag ctgaagtccg gcaagcttca aagcgcgcgg aatcgcttcc accggtccga 2785201 ttcccatcac ttccggcggc acgccgccta ccgcaaagga gcggaatttc acaagcggcg 2785261 ccaggccaag agcatcggct ttttcccggt ccatcagcat gacagccgcc gctccgtcac 2785321 tcgtttgtga ggaattgccc gcagtcaccg tcccgtcaac ggaaaaggcc gggcgcaatg 2785381 tcgataagat gtctgcagtc gtttgcgggc gaacaccttc atcctgagaa aacacaaact 2785441 gtttttccat aggcttatgg tcttctccga tttctgtcac cgtcacttcg acgggtacaa 2785501 tttcatcttt aaattttcct tctgcaaggg ctttagcggc gttttgatgg ctgcgaacgg 2785561 caaacgcgtc ttgatcctca cgggagacgc cgtatttttt cgcgacttgc tcggctgtgt 2785621 gccccatgct catataatat tccggtgcct tttctgccaa agcaaggttc ggacgggtaa 2785681 catgccccat catcggaact tgcgacatgg attctgctcc gccggcgatc gctgtatcgt 2785741 aggcgcccag cataattttt tctgctgcat acgcaataga ctgaaggcct gaagagcaat 2785801 agcggttaac tgtaatcgcc ggaaccgtgt acggcaggcc cgcgagcgca ccgatatttc 2785861 tcgccatatt aagcccctgc tccgcttcag gtgttgcaca gccgataatc aagtcatcaa 2785921 tattgccttc gtagccgcct gcccgtttca gcgtttcttt tacacaaatc gctcccaaat 2785981 catccgggcg aacggtggcc aacgatcctt tttttgcttt tccaaccggt gttcttgcac 2786041 ctgacacaat gactgcctct ttcataagct ccctcctaat tccgtaaagg tttacctttc 2786101 acaagcatat gctgcattct cgcttgagat tttgcctctc ctgacaaact caaaaacgct 2786161 tctctttcga tctccaataa atactcttca tcaacctctg taccaaacgg cacttttccg 2786221 cccgcaatga cataagcgag ttttttcgcg atcttaaaat catgctcaga tatatagccg 2786281 gacagcttca tctgctcagc gccaagcaag agtgccgcat aaccggtttc tcccggcacc 2786341 ttgacctttt cttttacagg cggccgccag ccggtatcgt ataaagatgc ggccagctgc 2786401 ttcgcatcgt ataacaggtg gtcttgattc acgctgatct gatccgtttc ttttaagatg 2786461 ttcatctcac gagcctcttg agcggaagcg gacactttcg ccatcgcgat tgtttcaaat 2786521 gttttcattg ccgcattcat cggatcatgg ccgcggcgaa gatggttgat gtacagctct 2786581 ttgttacctc ctccgccagg gatgaggccg acaccggatt ccacaagtcc catataggct 2786641 tcgcttgccg cttgaatgcg cgccgccggc aggcatgctt ccgttcctcc gccgagcgtc 2786701 atgccaaatg gcgcggcgac gaccggtttc gcactgtatt tgatcttcat catcgtctcc 2786761 tgaaaacggc ggatcacaaa atcaacttcc aaaaagttgt catcttggac ttccattaag 2786821 atcatggcga gattcgcgcc gacgcagaaa tttttccctt gattgccgat gacaagcccc 2786881 ttgtaattcc gttctgtttc ctctaatcct ttgtggatca tttgaatgat atcgaggccg 2786941 atcgcattgc ttttcgaatg aaattcaaga agggccacat catctccaag gtcaattaag 2787001 cttgctccgc tgtttttcgc aatcacgcct tttgtttctt taagtgcttg taaatgaatt 2787061 cgttttttgt tttctttcac ggctctgtat tcgccgcggt cataataaaa taccgttccg 2787121 ttctctttga tgtagaaggt ttcatttcct ttgtccagca tctcttttat ccagccaggc 2787181 atatctgctc caagctgctc aagcttttcc gctgactgct tgaggccgat ggcgtcccac 2787241 atctcaaaag gtcccagttc ccagccgaat ccccacttca tggcttggtc aatcgcatga 2787301 atatcatcgg caatctcgcc aagcagctcg gctgagtaaa gcagggtttg agaagtgata 2787361 ttccacagca aacggccggc cctgtcatcc gaataaataa gcgctttcat tttggctttt 2787421 gtcccttttg cctgttttgc cgcttcaagt gccggtgatt tcatttttgt ccgctcgccg 2787481 taagtaagcg tcactgggtc aagctcataa atcgtttttc cttctttttt ataaaagcct 2787541 tggccggcct tgcttccgat ccaccctttt tccagcatat cgttcatgaa gcttggaatg 2787601 cgaaacactt ctttttcatc gccatcagct ttgtcataca catttcgggc aacgtgggcg 2787661 aatgtatcga ggccgaccac atcaagcgtt ctaaaggtgg cgcttttcgg cctgccgatc 2787721 agcggtcctg tgatcgaatc aacctccccg acctgataac cgcctttcag catttcttgg 2787781 actgtcacga gaagcccgta agtcccgatg cggtttgcga taaagttcgg tgtgtccttt 2787841 gctgtaacaa cgcctttccc gaggacattt tctccgaaag ctgtcataaa ctttaaaata 2787901 tcaggatccg tttccttaat cggaatgatc tctagcagct ttaaatatcg tgcgggatta 2787961 aaaaaatgcg ttccaagaaa atgggcttta aaatcatccg accggccttc agccatttcc 2788021 tgcactgata tgccggatgt gttgcttgag acgatgcttc cagtctttcg atgttcatcc 2788081 acaagagcga aaattttctt tttgacttca aggttttcga caacgacctc aataatccaa 2788141 tctgcttctt tcagtttttc tgcatcatcc tccagattgc caggtgtaat ataggaggta 2788201 tttttcgctg atgtgagggg agcgggcttt tgtttcagca gttttttcat cgcctgccgg 2788261 ctcagcctgc tgcgcacctc cgaactgtcc ttcgtcagcc cctttttttc ctcttccttt 2788321 gtcaaatcgt tcggcacaat atctagcagc aggacaggaa ttccgatgtt agccaaatgc 2788381 gccgctatcc cggaacccat tacccccgat cctaaaacgg ctgccttccg aatgtgtttg 2788441 tgcatgagat atcccccttg aacattgaat gaatagtcat tcattttttg actaaaaaaa 2788501 atgaaacccg tttcttcttt catcttaaaa gatttccggt tcgacttcaa tagctaattt 2788561 gttatttttt tgtatgaagc ctataaaagt cgggcaactt aagcccggag gtgaagggaa 2788621 tggtacgaga gaaaaaaaat ccgtcttcag cggcagtcag cgcggcgagc gtaaagggag 2788681 atgccggtcc gactcagcat tacggcggcg gaaaacggac aagtcaaaat cagcagtata 2788741 aaaaacataa catgggacaa tcataatgca gctgcttccc acggctgctt tcactttttc 2788801 aaaattcctt ttaacacaaa cgctgcattg gcaggccgtt cggcaattct tctcataaag 2788861 tagctgaacc agtccgttcc atatgggaca tacacacgca ttctgtagcc ttccttggcg 2788921 agttccttct gacgctccgg cctgatgccg tatagcattt gaaactcaaa ttgcgatgcg 2788981 gggatttgat gttcggcgac gagctgtttc gtaaatgcaa tgatgtcatc gtcatgtgtg 2789041 gcgacagccg tgtagttccc gcttaacaac tgcagcttta ttaagctctg aaaatgaagg 2789101 tccgtgcctc ttttgtcggg aaacgctaca gccgcagatt ctttataagc gccttttaca 2789161 agtctgagat tcggctttaa gtcccgcatc tttctgatat cttctgccgc ccggtacaaa 2789221 tacgcctgaa tgaccgtgcc gagcttctca aattcctgtt tgcattgcct gtaaatagaa 2789281 agtgtctgtt cataatgaga atagtcttcc atatcaatgg tcacagcaac atcatattgc 2789341 ttcgcaacgg aaagaatggc gcgcaaatga gtaagagcaa gttcttctga aagatcgagc 2789401 ccgattgagg tcagcttaag tgaaagctct gaattcaatt gatgttcggc aatggcttga 2789461 atggctttct tgcattcctc tgcgacttgg tttgcttctt tttccgaagc tgcatactcg 2789521 cctaaataat caattgttgc acacaaaccg gatctgttta gccttttgac ggtcttaacc 2789581 gccgattcaa tcgtatcccc tgcgacaaac cttcgtgctc caagccgcgt tccgtatgct 2789641 tttgcgaact tggtaagtgt tttattttga gataagaata aaaacacatg tctcaacatc 2789701 cgactccctc ccgccgtcat cttcaaaaca cctgtatata actcccagtc tgaaggaaac 2789761 tataaaatga acagaaacca aaggaggatc acaatggata atcagcagca atctcaaatg 2789821 ccgccttccg ttatttcgac aaaggatcat ttgtatctca atgacatgct gaactggaat 2789881 ttgctcgcga tgaaaaaagc gcatttcatg gcgcagcagt gccaggatca aacgttaaag 2789941 caagaactcg accgcgtcgg acacatgcat catgatcact atcaaagaat attaaagcac 2790001 ctgcagccag gccagcagca gtccggctac atccaataag gaggcgccag aatgaatcag 2790061 caaaatcaaa aaatcagcaa cccgcagaca cctgtaccga caacatcgga aatgaatgac 2790121 agagatttcg tcaacgaatt gctgacaacc gaaaaataca tgacaacagc ttattgcact 2790181 gccttgcacg aattcagcca cgagtctctt tatcaggata ttcaatccat ttttgatgag 2790241 tcacaaaaag cgcaaagaaa actatatgat ctcatgttcc aatatggatg gtattctgtt 2790301 gaagcggagg attcacaaaa gctgcagcag tcctatcaaa aattccagca gaccattcag 2790361 cagcagtctc cttatcagca ataacaacat tagtaaaaag gatacgatgt tctttcgggc 2790421 atctatcctt tttttgtgta aaatcagttg acttttcatt tacgcttatt tatatttaat 2790481 aagcattaac tattttgtca ttaaaatata tatacagtgt atgtaacaga ggggaaatga 2790541 atatgaagag tgcggatcag ttaatgtccg atattcaatt atcgcttcag gcgctctttc 2790601 aaaagataca gcctgaaatg ctggaaagca tggagaaaca aggtgtcacc ccagcgcagc 2790661 tgtttgtgct ggccagccta aagaaacacg gcagcctcaa agtttctgaa attgccgagc 2790721 gtatggaggt gaagccaagc gcggtgacgc tgatggcaga tcgccttgaa caaaaaaatc 2790781 ttatcgccag aacacacaac acaaaagaca ggcgagtgat tgatctcagt cttactgacg 2790841 aaggagacat aaagttcgag gaggttttgg cgggcagaaa agccataatg gcgcgctatc 2790901 tttccttttt gacggaggag gaaatgctgc aggcggcgca tattacagca aaactcgcac 2790961 aagcagcaga aacggatgaa aagcaaaaca tgaaaagagg aaacggatga aaatgagtaa 2791021 agaaggcaaa caatcaaaac gaacgttatt aataacaggc ttaattattg ccatgttttt 2791081 ttcagccctt gacggtacca ttgtcggaac ggccatgccg aaaattgtcg gtgatctggg 2791141 cggtttgagc atgatgacct ggctgacaac tgcatatttg ttaacatcaa caaccattgt 2791201 tccaattgcc ggtaaactgg ctgatttatt gggacgccgc attgtctatg tatcaggttt 2791261 gattattttt atggccgctt ctgctttgtg cggaatggcc aacaacatga cggaattgat 2791321 tatcttccgt ggactgcagg gcatcggcgg aggcatcatg atgccgatgg cgatgattgt 2791381 catcggtgac ttgttcacag gaaaacagcg tgctaaattc caaggtgtct ttggcgcaat 2791441 ttacgggctg gcttcagtga ttgggccgca aatcggcggc tggattgtag actcgttaaa 2791501 ctggaaatgg gttttctata ttaacctgcc agtcggaatt attgcggtta tttttattgc 2791561 caggggatta cagggacgcc agcagactgg tccgatcaac ttcgatatcg ctggtatttt 2791621 cacaatgatt gtcggtgtgg tcagcctcct gctcgcctta agctttggcg gaaaagatta 2791681 tgcatgggat tcatggcaga ttcttgggtt gttcgctctc gcactgatcg gcattgtcag 2791741 ctttatcatc gtagaatcaa aagcaaaaga gccaatcctg ccaatgtatt tatttaaaaa 2791801 cagaacattt acatttctaa acttgatcgg cttctttatg agtatcggta tgtttggcgc 2791861 cattacgttt gttcctttct ttatgcaggg aattgtcggt gtaagtgcgt ctgaatcggg 2791921 tacaattatg acaccgatga tgatttctat gattatcaca agtatcatcg gcggacagct 2791981 tgtttataaa attgggatta aaccgcaaat cattacaggc atgctggtta tggccggcgg 2792041 attcctgctg ttaacgacat tggatctcga cacgagcaag cttgtcgcta catcttttat 2792101 ggcgattatt ggtctgggaa tgggtcttgt tatgccgatt ctgacattgg ctttacagga 2792161 aagcttttcg aaggaggagc ttggagttgt cacttcatcc agccaattct tccgttctat 2792221 cggcggaaca ttcggcatta ccatgctggg agccgtaatg aatgcgagat caggaaatct 2792281 attaacagat aaattggttc catatttaga ctctcttccg gcacaggcaa gctcgtttgc 2792341 cgcccagcta aagggtatga ttgatacaaa tccgcaaggg ctgctgcaat cactgttcag 2792401 tccggacgcg gtcaaacaaa tccctgcggc tttctcatcc catattgtgc cgattttaaa 2792461 aacatcgttg atggattcgc tccacagcgt gttttatacg ggcctgatct ttatcgcagt 2792521 cggagccgta ttcaccttgt tcttaaaacc tatcaagcta tcaaataaga aagcggaaga 2792581 ccaacaagaa aaagagaagg cggcaaaagc cgttgaatca ccttcccatt aatagagcac 2792641 cccgcgggta tcaatccgcg gggtttttta ttcaatcatc tgggctcttc catttccgaa 2792701 agaccaatcc tcatcctgat ttccggccag catgataaac acatcttctt ttcttacacc 2792761 aagctcggaa tgaatccggc tcgcgattga gcggtaaagt gcttttttct gttcagttgt 2792821 tcttgactgt ttcagtgtaa aatgaatgta tatcagttca tcagtacgct cgacttggag 2792881 ataaaatgga tcataaaaaa attcgctttt ttcatattgt ctgatgactt ggaaatagtc 2792941 atcttccggc acattgattt cttcaatcat cgattggtgg atagtcctgc tcagtttttg 2793001 aagccacact tcgcttcttc ccgaccgtaa atgaatctgt acaaatggca tctccccgca 2793061 tccctttctt tacagcgtct gtccgctgtc aattgtgata atttggcctg tgagtgattc 2793121 ctgttcaatt agtgaacaaa tcaatttggc aacatcatct ggttcagcaa tacactgcag 2793181 cagcaaagag ccgatcatgc ttttcatttt ttcttcccgt ccggcccacc atctcgttgc 2793241 cacagctcct ggtgctacac cgctcactct gatttcaggc gctaaggcgt gggccaatga 2793301 tttcgttaaa ccgtgcaccg ctgattttga tactgcgtaa ggcattgatg agccggcacc 2793361 agttatccct gcgatgctgc cgacgtttac gatcgccccg tccttgcttt tcttcatgaa 2793421 cggaaccact gcccgcgcgc agaaaaacat ccctttcaca ttgacggcat acagctcatc 2793481 ctagacgtct tctgtcgcag cctcaagatc atccattgga atatgccgtg taatgctggc 2793541 attgttgact aaaatatcaa ccgtgccgtg tgtgttcacg attgcttgaa tcatatcctg 2793601 cacgtcgctg tttttggata catctgcttg gatggcgaag gcttgcccgc cagctttttg 2793661 aatcatttcc actgtttcct ccgcttctga ttgcgagcgt gaataattca ccgccacaat 2793721 cgccccacgc tttgccaatt ccatactggc tgcttttccg attcctgtgc cgccccccgt 2793781 tacgagagct attttgttca agacattcat tgccgccact ccttgctgtt gactaaagta 2793841 tatttctgat tccattgtaa tccagctttg atgttacgta taatgattgt taaagatact 2793901 agatatcact cagattgata gtaaacgaac ggaggagttc aaaatggaaa gcggagattt 2793961 acgtgtgttt caaatggtag ctcgtgaagg gaccattacg aaagcagccc tgcagcttgg 2794021 ctatgtacaa tcgaatgtca cggccagaat tcaacaattg gaagctgagc tgggtaccac 2794081 actgtttttg cgccataatc ggggcatgac actttctgca agcggaaaat tgctgctgga 2794141 ctacgcaaat aaaattatag gccttcttga tgaagcgtct aaagcgctct catcctccgc 2794201 agaaccaagc gggccgctta tgatcggctg cactcagaca accgccgcgg taaggcttcc 2794261 aaagcttctg gcatcttatt atgaagaaca tccaaacgtc cagctgtctt taacaacagg 2794321 acatacgcaa tttctccttg ataaagttct tcgttatgaa ttggatggcg cgtttatcgg 2794381 atgcgaatgc catcatcctg agctcgaatc ctatcctgcg tttgaggaag aaccagtagt 2794441 tgtttcggct gcctccgtgc ccgatgttga ggaagccatc acaaagccga ttctcgttta 2794501 cagcacaggc tgttcgtatc gagaaacact tgaaaaatgg ctgcgttccg tcggtgtcac 2794561 acagccggtc attatggaat ttgggacgct tgaagcaatt atcggcgggg ttacagcagg 2794621 tcttggcatc tcgttgctgc caagaacggt tgtgcagaaa catgaagcag aaggatcaat 2794681 tcgattgtac ccgctgcctg aagctctcag ccagatgaaa acagagttta ttgttcgaaa 2794741 agattcgttt atcagcagcg cgctgagaac ctttatggat tcctttacgc cagttaaaac 2794801 ggctgaatca caaaaaagca gtctgctata atgaacagac tgctttttgg ctattgtttg 2794861 tttcgatgcg cttcatttaa ttccttaata tgctgaatga tctctttaat gccctgcttc 2794921 gcgtcggggt atgtcgcatt ccaatgctta gcgagcggag gcatgctttt ggctatatgg 2794981 gtgtacaaaa tccattgctt cacttcttct tttagctcat cgtttgtttc accaagcaga 2795041 agctcagtat acttctccag caatccatca agctgctcct gaagtttttg ttccattttc 2795101 catcttcctt tcgaaaaaac agcaaggagc tttctcaatt gaaagctcct tcgctgcgtt 2795161 atttatccat gtgatgtgaa agccgcttcc tggacaatgc atctgcccct gccatgagga 2795221 atgcaaagag gcgttccgaa gagcgggtcc tgtgtaacct gacagttcat agaaaacaca 2795281 ttttgcacaa gatcacaagt gatgacctct tccggacggc cttctgcata aatccgttta 2795341 tcttttatgg ccacaagatg atgcgcatag cggcacgcca agtttaagtc atggagaacc 2795401 ataacaatcg tccggtcttc cttttcattc agctcaaaca gcaaatcaag aatttcaatt 2795461 tgatgcgtca tgtctaaata cgtcgtcggc tcgtcaagaa ggatgatatc cgtttcctgg 2795521 gcaagcgtca tcgcgatcca agcccgctgg cgctgtccgc ctgacaaaga atcaacggca 2795581 cggtcagcca tgtcctcaag ctttgttgct ttaagcgctc tttcaactgc ttcctcatcc 2795641 tcttttgacc actgcttcag ccagttttgg taaggatatc ttccttgctt caccagctga 2795701 tgcaccgtca gcccctctgg agccgaagga ccttggggca ggattgcgag ctcttttgcg 2795761 acttccttcg tcggaagctt ggcaatcgct cttccttcca gcagcactga accgcctctc 2795821 ggcttcatca ggcgcgctaa tgaacgtaaa agtgtcgatt ttccgcagcc attgctgcca 2795881 ataaatacgg taatttcacc tttgggaatt gttaaattca actcatcaat aataacggca 2795941 tccccgtatc ctaagctcag cgtttctgta gaaattgcac tcatacccat aaccgctcct 2796001 ttttgctggc tttttagcag cactatgtat tgcacgtttt ctatatacat gcttttaagt 2796061 caattgtcat caatgcaaat gattccgata ttcagccatt tgatatggtc atatatccct 2796121 cattgtagca gaaaacactg actttgaaaa tcattttcaa ttagttttat ggacataatt 2796181 gacgtttatg ggttttttat cacaagatta cttcttgatt tctctgatgg agccgtcctt 2796241 cagcttcaat tttaaatcga tatgatcata atgactgtcc agattaaatg ctgccagcac 2796301 actgtgtatc acttctgttt cagccatttg gtctgtcacg gaaagctcgc tcaaaatcat 2796361 tttcatctca tctaacgctt cttctccttc ctgattgaca ccggagagct tatcctgtat 2796421 ttccgctttt tcctgagtcc cgttctttgt atagattcct tcataacggt tatgctcacc 2796481 atccccgtag ctcacacgaa gcgaaaaatt actgtaggga acggacttca gctgggtgac 2796541 ggctgtattt tctccttctg cctgatgctg gtcttcattg aaacggcagc ccgcaatcag 2796601 aaccactgcg agacatacag ccccggctgc tctgatcaaa tgcatatgtt tcccccctgt 2796661 aggattccat ttattttagg tatatccaga gaatgaaatc ctcattcaga gaagaattga 2796721 aaaagccggg gcatttaacg ccacggcttt ttctttaaga ttcggtcatt tgtaaaaagg 2796781 tttcggcgtc acgcacagcc agcttgatgg cattctccca gaaatcgcgc tttgtgatgt 2796841 cagcgcccaa atgcttcatc gccaaatcct ccactgtcat agaagccgta tcgcgcaata 2796901 gcgccatata cttctcttcg aatgtgtctt tttcttcaag cgccaacgcg taaataccaa 2796961 gagaaaacag gtagccgaat gtataaggga aattgtaaaa cggcaccctc gtgatgtgaa 2797021 aatgaagctt tgatgcccaa aaaagcggat gatattcttc taacgcattg cagtatgcct 2797081 ctctttgcgc ctcttccatc agctcattca agcggctggc cggtaccact ccccgctttc 2797141 gttcctcgta gaatctcgtt tcaaatagaa atcttgcgtg aatgttcatg aagaacgcaa 2797201 cgcttctttg cactttatcc tccagaagaa caagcttttc ttccctcgtc tcggcctgct 2797261 ggacagtcgc gtccgccact atcatctctg caaacgttga agctgtttct gcaacgttca 2797321 tggcgtagga acggtttaac ggcctgacgt tgagcattgc ttcctgatgg aacgcgtgcc 2797381 cgagttcatg cgcaagggta gagacatttg aggcgcttcc cgaaaatgtc atgaaaatcc 2797441 gggattcccc gctgtccgga aaactggtgc aaaagccgcc gactcttttt ccgctcctgt 2797501 cttccgcctc aatccagccg tcccgaaacg ctttttcagt gaatgaggac agctttttgc 2797561 caaacgttga aaactggctg gtaatgatat ttgcggcttc atcatacgaa tagacctttc 2797621 cgtcagaacc gatcggtgcc tcgacatcgt accagctgag tttttcaagg ccgagcatgg 2797681 atgctttccg gttcaaaaac tgaacgaacg gcttcttgtt ttcagtgatg acctgccaca 2797741 tcgtatcaag tgtttctttt ttcatcctgt taatttgcag cggttccttc aggacattct 2797801 cccagccgcg cgctttatag gtttcaagcc ggaatcccgc caaatgattc agcgtgctgc 2797861 tgaaaatatc ttgcttgctc tcccaagctt ggcggaaacg ttcatatact gtttttctga 2797921 cagtacggtc ttgatgatcc atcatattct ccgcctgacc gacagacaat tgcttgtttt 2797981 caccgttttc ctcatacggg atcgtcattt tcccgacaac catattgtat aagtcactcc 2798041 aagcgtgata tccgtccacc gcaaggtttc cgatcagttt ttccttaccg gggctaagct 2798101 tttcggcaac cctctgtctt ctttcattta atatgtaaga aacatcgcgc aatcccggtt 2798161 ttgttaacaa ttcattccac acgtcttgat taatgtccac aagtttatga tctaatgtaa 2798221 cgagcgacga ttgaaaatct gcggaaagcc gattcatgag gcctgatgct ctatagcctt 2798281 ttgatcattg atattctggg cctggaggca agcaacaaaa gcgccggcct gctgaagctt 2798341 gacggatgtc tgttcgaata aatcaagcaa cgcggtcagc ccttcagcct cttcaggcga 2798401 ttcaggcacc tgaaacgcat cagtcctgtc ttgaaatgca cgcagacttt gtgacagctt 2798461 ctcaatataa cctttgaatt cttccgattg gctcccgccc ttaaaaaatg aatcaagatc 2798521 ccatctttgg cctacccctt gcagcgccat atcacaaaac ccctttcctt ctttcgttct 2798581 attatagaac aattctgaat tattgtataa aaatttctat tacaggcgtc atttcgtgtt 2798641 caggatagta caatagctgt agcagtttaa taggagggtt aggatgaata aaaaaatagc 2798701 catcgtgaca ggagcgtcca gcggcttcgg tctgctggca gctgtaaagc ttgcccgatc 2798761 atttttcgtg atagccacat caagacagcc tgaaaaagcg gaacagcttc gagaattggc 2798821 tgcagcacac aatgtgtctg attctattca cattacagct ctcgatgtca ccgatgaaca 2798881 atctatagtc tcattcggaa aagctgttag tgcttacgcc ccgatcgatt tactcgttaa 2798941 caacgccgga acggcttatg gaggatttat cgaggatgtg ccgatggaac atttcagaca 2799001 acaatttgaa acgaatgtct tcggtgtgat ccatgtgaca aaaaccgtgc tgccttacat 2799061 aagaaagcat ggcggcgcaa agattataaa cgtgagcagc atcagcggac tgacaggatt 2799121 cccagcgctg tcgccatatg tttcttccaa gcatgcattg gaaggttttt ctgaaagcct 2799181 gcgtatcgag ctgcttccgt tcggtatcga aaccgctttg atcgagccgg gctcatacaa 2799241 gacatcgatc tggtcaacgt cattatcaaa ttttatgtcg gtgcctgctg acgattcagc 2799301 ctatcatcaa tactataaaa agatcctttc ctatgttcaa aaaaacggag aagaaagcgg 2799361 agatccccaa gaggttgccg acctcattta tcaattggca acaaaacagc acataaagaa 2799421 tttgcgatac ccgatcggaa agggcatcaa gctcaccctg ctgttccgat cgctttttcc 2799481 ttggtctgcg tgggagtcta tcctgaagaa aaagctattc agctgatcta aattataatt 2799541 attataattt agtattgatt tttatttagt atatgatata attaagtcaa cagatcacaa 2799601 ggaggacgtt atcttatgaa aactgaaaac gcaaaaacaa atcaaacatt agttgagaat 2799661 tcactgaaca cacaattatc aaactggttt cttttatact ctaagctcca ccgtttccat 2799721 tggtatgtga aagggcctca tttctttaca ttgcacgaga aatttgaaga actttatgac 2799781 catgcggctg aaacagtgga taccatcgct gagcgcctgc tggcgattgg cggacagcct 2799841 gttgccacag tgaaagaata cactgagcat gcatctatca cagacggcgg aaacgaaaca 2799901 tcagcatcag aaatggtaca agcattggta aacgactaca aacaaatcag cagcgaatct 2799961 aaattcgtga tcggcctggc tgaagaaaat caagacaatg cgacagcgga cttgtttgtc 2800021 ggattaattg aagaagttga aaaacaagtg tggatgcttt cctcttattt agggtaacaa 2800081 aaaagctgaa ccttaatcgg gttcagcttt ttgttttttc ttagcttgaa ctgctttctg 2800141 tctgcttggt cagtgttgcg ttcaacgttt tcgtttttcc ctttcgcagc acttggattg 2800201 ttgttttatc tccgactttt aagtctttgt aaaggatctg acggatatcc gcactgcttt 2800261 ccacgtcttt accgtttagt ttgacaatga catcctcaga tttaatacct gctttttctg 2800321 ccggcgaatt tgcttgaact tcttttacat aaacaccttt gcccaattga tctccaaaca 2800381 ggccgagcgt attttcctga taggtttcag gaacttgtga catgtcaatc atctgcacgc 2800441 ctaaaaacgg acggtccacc ttcccgtttt gcagcagctg gtcaacaatc ggctcgacat 2800501 cattgcttgg gatcgcaaat ccaagtgatt ccacgccgct ttcgctcacc ttcaagctgt 2800561 tgatgccgat gacctggccg cttgcattga ttaatgggcc tccgctgttc cccggattga 2800621 tcgctgcatc ggtttgcagc acgttcattt ccaccgtccc ctgtgttgta tccacatcaa 2800681 ttgtccggtt cagtccgcta atgatacctt gtgtcactgt accggaaaac tgctgtccga 2800741 gcgggttacc gatagcgatt accttttcgc cagtgcgcag ctgtgaagag tcaccaaagc 2800801 tcgccacttt ttttacattc ttgccgctga tttccaaaac tgccaaatca gtaatggtat 2800861 cgctgccgac aagcttggca gtttccgttt ctccgttgta tagcgtaaca gtcagcttgt 2800921 tcgcgccttc aacgacatgg ttgtttgtaa tgatatacgc tttatcgctg tcttttttga 2800981 aaataacacc tgacccggtt ccgctttcac tttctgagct ggagcctcct cccgtgccga 2801041 atgtgttatt ttgagaggtt tggatatttg agattccgac aatcgtaggc tctaaatcct 2801101 ctaccatatc agcgatgttt gatgcgttcg ttatcggcgc cgttgtaaaa ttatcagact 2801161 gcacctgttt atttgcggaa gcggtttcgg tcgcctgatt ttggtctgac ggcagataag 2801221 gcgcgatgcc aagcatgagg cccccgccga taataccgcc taaaatcggg ctcagccatg 2801281 cggctctccg tttcttttct tttttcacag ccgtttcttg cttttccatt tctaaagcag 2801341 aagccgtttc ctgccgtccc gcttcatacg acacaggcgc gtcaagcaat tcttgttcag 2801401 aatgtccaat cagcttctgg ttttctgtat tctgctgttc tgtatgtgaa ggttcagttt 2801461 gatgttgatc gttttggcca tcacgtcgat aatccatgtt cttacactcc tttaacggtt 2801521 attcatttat cgttacatat tcatcgcatg tacaagttca attgtcccaa taatgaggag 2801581 aaaagcaaag caccaaaata gaatatgttt gatcatccta catcttcctc gctctttttc 2801641 tcttcctttc ttcccttaac catatcataa acaaacattg tgggataaaa atgaaaagaa 2801701 tatgtgaaat tatgaaaatt gcctgccgta tgttaaaact agtttataat gacgttgaaa 2801761 ggatgtgaag agccttgtca tacaccattt atctagttga agatgaggat aacctgaatg 2801821 aactgctgac gaagtattta gagaatgagg gctggaacat tacatctttt acgaaaggtg 2801881 aagacgccag aaagaaaatg acaccgtctc cccacctatg gattctcgat atcatgctgc 2801941 cggataccga cggctataca ttaataaaag aaatcaaggc gaaagatcct gacgtgccgg 2802001 tcatttttat ttccgcccga gatgcggata ttgacagagt gcttggctta gagcttggca 2802061 gcaatgacta catttcaaag ccgtttttgc cgcgggagct gattatccgt gtgcaaaagc 2802121 tgctgcagct cgtatataag gaagctcctc ctgtccaaaa aaatgaaatt gccgtctcct 2802181 cgtatcgggt cgctgaagac gcccgcgagg tctatgacga aaacgggaat atcatcaatt 2802241 tgacgtcaaa ggaatttgat ctgctgctat tatttatcca tcataaaggg catccatact 2802301 ctcgtgagga tatcctccta aaagtgtggg gacatgacta cttcggaaca gaccgggtcg 2802361 ttgatgatct cgtccggaga ctgcgcagaa agatgcctga attgaaggtg gagacgattt 2802421 acggtttcgg ctacaggatg atgtcatcat gaaaaacaag ccgctcgcgt ttcagatatg 2802481 ggttgtcata tccggcatcc tgttagcgat atcgatttta ctgcttgtgt tattttcaaa 2802541 cacgctgcga gattttttca ctaatgaaac gtatacgacg attgaaaatg agcagcatgt 2802601 tctgacagag taccgcctgc caggttcgat tgaaaggcgc tattacagcg aggaagcgac 2802661 ggcgccgaca actgtccgct ccgtacagca cgtgctcctt cctgaaaatg aagaggcttc 2802721 ttcagacaag gatttaagca ttctgtcatc ttcatttatc cacaaggtgt acaagctggc 2802781 tgataagcag gaagctaaaa agaaacgtta cagcgccgac gtcaatggag agaaagtgtt 2802841 ttttgtcatt aaaaagggac tttccgtcaa tggacaatca gcgatgatgc tctcttacgc 2802901 gcttgattct tatcgggacg atttggccta taccttgttc aaacagcttc tgtttattat 2802961 agctgtcgtc attttattaa gctggattcc ggctatttgg cttgcaaagt atttatcaag 2803021 gcctcttgta tcatttgaaa aacacgtcaa acggatttct gaacaggatt gggatgaccc 2803081 agtaaaagtg gaccggaaag atgaaatcgg caaattgggc cataccatcg aagagatgcg 2803141 ccaaaagctt gtgcaaaagg atgaaacaga aagaactcta ttgcaaaata tctctcatga 2803201 tttaaaaacg ccggtcatgg tcatcagagg ctatacacaa tcaattaaag acgggatttt 2803261 tcctaaagga gaccttgaaa acactgtaga tgttattgaa tgcgaagctc ttaagctgga 2803321 gaaaaaaata aaggatttat tatatttaac gaagctggat tatttagcga agcaaaaagt 2803381 gcagcacgac atgttcagta ttgtggaagt gacagaagaa gtcatcgaac gattgaagtg 2803441 ggcgcggaaa gaactatcgt gggaaattga tgtagaagag gatattttga tgccgggcga 2803501 tccggagcaa tggaacaaac tcctcgaaaa cattttggaa aatcaaatcc gctatgctga 2803561 gacaaaaata gaaatcagca tgaaacaaga tgatcgaaat atcgtgatca ccattaaaaa 2803621 tgacggtccg catattgaag atgagatgct ctccagcctc tatgagcctt ttaataaagg 2803681 gaagaaaggc gaattcggca ttggtctaag catcgtaaaa cgaattttaa ctcttcataa 2803741 ggcatctatc tcaattgaaa atgacaaaac gggtgtaaca taccgcatag cagtgccaaa 2803801 atagactgta gatgttttgc agtctatttt tttatgtgaa agaatagccg ttaaaatctc 2803861 tgtaatttgt tttgagcggc tgtttgcatt gatgaaccca ttttttctct gacaaggtct 2803921 gcttcggata tttgactttc tccactttga ttcctctgtt tcgcaagcgg ctgatcattt 2803981 cgtccaattc tctcattcta gattcaccct ttcgcttgag ctttgaccat tcggtcatct 2804041 caatttataa tataaataat acatgataaa aaaacaagtt acaataaggt taattttata 2804101 acagacggtg tgactatatg gtcatatcct agcaggcctc cgggctccga aagggtggaa 2804161 ccattgaagg aaaaagaaaa actgattatt gaaacagcct taaaactatt tgcccaaaaa 2804221 ggatacaact caacatcagt ccaggaaatc gcaaaagaat gcaaaatatc taaaggcgct 2804281 ttttatattt attttccttc gaaagaagcg cttcttctct ctatgctgaa ctactattat 2804341 gataaaacgt ttacccgaat tttaaatatt aaaacgaagg gcgacagccc cagaacggct 2804401 taccgtaaac agctgaccgt cctctatgaa aacattcttg aacacaaaga ttttatcagc 2804461 atgcagttga aggagggttc tctgccttac acagaagaag tggagcaatg cgcaaaaaaa 2804521 atccgccagt cctcacttca atttcatatc gacagcctgc tgaacatcta tggaaaaaaa 2804581 gcggaaccgt acactgctga gctttgtttt ttaatagagg gcatcagcca gatttacctg 2804641 gaatgcatga ttttgctcgg gtacactgtg aagccgtctc aattagctga tatcattatg 2804701 aatcgaattg atgatatggt aaaaggcatg tctgaacgaa acgataagcc tttcatcaca 2804761 ttggaagagg cgagctcttt attcggacct cttacgcacg gacggcctga cccgctgact 2804821 gaatcaattg tgaaaagcct acgtgacaaa attaacagct taaacacaaa ctcctctctt 2804881 gaattatcgg agagcttgga catacttgaa gcagaaatga agaaaaaaac accgaagctg 2804941 gcgatcataa aaggaatgat tcataatctg acggagtctg aagctctcgc caaagatgcg 2805001 gaacagctta aatatttatt aaaacagcaa catatttaga agaacggctg cttaaaaagc 2805061 agccgttctt cctattacgc ctttggtttt accatgtctt ccggcttaac catttcgtta 2805121 aattgctcct ctgtcagcaa ttcaagcttc aaagctgctt ctttgagcgt caatccctct 2805181 ttatgggcaa gcttggcgat tttcgccgcg ttttcataac cgatatgcgg gttcagcgcc 2805241 gtaacaagca ttaatgaatt tgacaggttt tcctgaatgg tttctttatt aggctcaata 2805301 ccgacagcac atttatcatg gaatgaattc atgccgtcac tgagcagctg cacagattgc 2805361 aggaagttgt aaataataac aggcttaaac acgttcagtt caaagttccc ctgactcgcc 2805421 gcaaagccga ttgtcgcatc gttccccatg atttgcgctg cgatcattgt taacgcttcg 2805481 ctttgtgtcg gattgacttt accaggcata atagagcttc ccggctcatt ttcaggaatg 2805541 acgatctccc cgatgccgca gcggggtccg cttgcgagcc atctgacatc gttcgcgatt 2805601 ttcattaagt cagccgcaag cgcttttaat gcgccatgcg cataagtgat ttcgtcatgg 2805661 cttgtcagcg cgtggaattt attcggcgag ctgctgaacg tttggccggt cagcttagtg 2805721 atctcttctg agacaagctc tccaaactct gggtgggcgt tgatacccgt tccgacagcc 2805781 gttccaccaa ttgcaagcgc acgcatttta tctgtcgctt ccaaaatcat ttccttcgaa 2805841 cggtccagca tgtgaaccca tccgctgatt tcctgtccga gggtcagtgg cgtagcatcc 2805901 tgaagatgcg tgcgtccgat tttgacaata tcattgtatg cttttgcttt ttcatccagt 2805961 gtattgcgaa gctgatcaag cgccggcaca agctgctcgt aaacagccaa aacagcggca 2806021 acatgcatcg cagtcgggaa tgtgtcgttt gagctttggc ttcggttcac gtcatcattt 2806081 ggatgaatcg tttgatcaga gttcttctct tttaataaag cagtcgcacg gttggctacc 2806141 acttcgttca tgttcatatt gctttgtgtg ccgcttccgg tctgccatac gacaagcggg 2806201 aagttgtcat cgtacttgcc tttgagcaca tcatcacaaa ccgctgcaat cgcttctgct 2806261 ttttcagcgt ccagattgcc gaggcgttta ttagctagag cagtgcttcg ttttaaaatt 2806321 gcaaacgcct tcacaacacg catcggcatt ttttcagaac cgatcttaaa gttctccttg 2806381 cttcgctgtg tttgggcgcc ccaaaattta tcagcaggaa cttttacttc tcccatggtg 2806441 tctcgttcaa ttctgtattc catttatgta tccctccata acggttgctt caatagatca 2806501 taattcgcca atgacacaaa aaatcctttt tatttttcga tcttggcaga ttttaatttt 2806561 aattcaagat atacgcggga atcctttgaa tatttgtatt ttggatttgt cctgccgtac 2806621 tcctttgatg tataagagac atcataatgc tgttcaaatg atctaatgag ctgttcaatt 2806681 tcttcttgtt ttccagctag ccttacctgt gccacttcgt atcctccgct ttcataaaaa 2806741 aacttactcc atgaaatact ctaacacagt atatcatttt tttaacagga aaagataacc 2806801 tctactaagg ttttggataa gaggtgacct cattggaaca aacagagttt aaggaatata 2806861 tacacgataa tttagcattg gtgctgccaa aattaaaaga aaacgatgat ctggtgaaaa 2806921 acaaaaaaat gcttgcgaac ggactggttt tttactatct ctatttcagt gaaatgactg 2806981 atgagaataa ggtgtcagaa gccattaaaa ctttgattaa agatgaggag accttaacgc 2807041 ttgaccaggt caaaaaacgc cttgaccagc ttgacgcaag acctgttgaa actgcaaaaa 2807101 aaacgattga atcgattctc aacggcaatt gtgctgtgtt tatcaacgga ttggataaag 2807161 cctatattct gaccacagga aagaaaaaaa caagaagcct gacagagccg acaactgaaa 2807221 aagtggttcg cggcccaaaa gtagcgtttg tagaggatat tgatacaaat ctcgctctga 2807281 tcagacaaag aacctctcat ccgaaattga tcaccaaaaa aatcatgatc ggcgaaaaca 2807341 agctgaagcc tgcagccatt atgtacattg aaggcaaagc aaaaaagtcc gtcataaaag 2807401 aagtgaaggc gcggcttaaa aatatccagc tggaagatat ccaggacagc ggaacgctcg 2807461 aggagctcat tgaagataat aaatattcac catttccgca gatacaaaat acggaaagac 2807521 ctgacaaagt atcttcagcc ctgtttaacg gccgtgtggc aattttggtc gacagttcac 2807581 catttgtgct gctggtgccg gtttctctcg gcatcctgat gcaatccccg gatgactact 2807641 atgaacgctg gatttcagca tctcttatcc ggtcgctgcg ctttgcttct atctttatca 2807701 ccttgttttt gtcatcgatt tatataacac ttgtttcctt ccatcagggg ctgctgccga 2807761 ccgcactcgc cgtcacgatt tcggcgaaca gggaaaacgt gccgttccct ccgatatttg 2807821 aagccctgct gatggaagtc accatcgagc tgctaaggga agccggactg cgactcccca 2807881 atccgctcgg acagacgatc ggcctcgttg ggggcgtagt catcggacag gctgctgtag 2807941 aagcgaatct cgtcagttcg attttggtca ttgtcgtcag tgtcattgcc ctggcatcct 2808001 ttaccgttcc tcaatacgga atgggtctgt ctttccgggt gctgcgtttt atttcgatgt 2808061 tttccgccgc tattttaggg ctatacggca ttattttatt tatgcttgtc gtttatacgc 2808121 acttaacgag acaaacgagc tttgggtctc cgtatttttc gccaaacgga ttctttagcc 2808181 tgaaaaatac ggatgactcc attatccgtc tcccaattaa aaacaaacca aaagaggtga 2808241 ataatccaaa tgagccaaaa acagactcca ctgaaactta atacctttca aggtatttct 2808301 attgttgcaa atacaatgct tggggccgga cttttaacat tgccgcgagc gctgaccact 2808361 aaggctaata cgcctgacgg ctggatcacg ctgatattag aaggtttcat ttttattttc 2808421 ttcatttatt taaacacgct cattcagaaa aaacatcaat acccttcact ctttgaatat 2808481 ttgaaggaag ggcttgggaa atggatcggc agcatcatcg gccttttgat ctgcggctat 2808541 ttcctcggcg tagccagctt cgagacacgg gcaatggctg aaatggtgaa gtttttcctg 2808601 ctggagagaa ccccaattca agtcattatt ttaacgttta tttgctgcgg catttattta 2808661 atggttgggg gcttaagcga tgtgtcgcgg ctgtttccct tttatttaac ggtaaccatt 2808721 attattttgc tgattgtgtt cgggatcagt tttaaaattt ttgatatcaa taatttgcgt 2808781 cctgttttag gcgaaggcct tggacccatt gcaaactccc ttaccgtcgt ttccatctct 2808841 tttttaggaa tggaagtgat gctgtttctt cctgaacata tgaagaaaaa gaaatacacg 2808901 ttcagatatg cgtctctagg atttctgatt ccgattatct tatatatcct tacgtatatt 2808961 atcgttgtcg gagctttgac cgctcccgag gtgaaaacgc tgatttggcc gactatttct 2809021 ctctttcagt cctttgagct taaaggcata tttattgaac ggtttgaatc ctttttactg 2809081 gtggtctgga ttatccagtt tttcaccaca tttgtcattt acggatactt tgccgctaac 2809141 gggctaaaga agacatttgg attatcgact aaaacaagca tggtgattat cggcataacg 2809201 gtcttttatt tttctctctg gccggatgac gccaatcaag tcatgatgta tagcgattat 2809261 cttggctata tttttgtctc cctgtttctg cttccgttca ttctcttttt cattgtagct 2809321 ctcaagagga ggattacaac aaaatgaaaa tccggatttt atgtatgttt atatgcaccc 2809381 tattgctgtc cggatgctgg gacagtgaga atatcgagga attaagctta gtgatcggaa 2809441 tagggctaga caagcctgac gatgaaaatt tagagctgac acagcaaatt ctcgtgccga 2809501 aaataatcag cgccaaggag ggctcttcat ctgatccgac acagctttct atcacaaagg 2809561 gtaaaactgt ccatcaaatg atgagaacct ctgcattaaa gcataagcct acgttttcac 2809621 agcatttgcg tctcattctg ctttccaaaa gcgtgattgc ggatcaaatt ggaatggacg 2809681 ccattattaa ccagtttgtc agagacaacg gaacaaggag gagttcctac gtctttatca 2809741 ccaacggccg aactaaggat atatttaaca tgaatgatga aggcgaaccc gcatccaacg 2809801 tgatatatga tctgacagag aataataagg tgacgatcag aacgatggag ccagttacat 2809861 tgggggagat ctcagaacac ttaacctctg acgattcatt cctcatccct catgtcggta 2809921 aggaaaacgg caagctcgcg ataaacggag cctctatcat aaaaaataaa ttatggcacc 2809981 gggacctcac cccgattgag gttcaaaata tcagcttatt ttcaggcact gtcgagggag 2810041 gcgtcattga cttgaagcgc gatggccatc tcttttctta tgaagtatat tcaagcaatc 2810101 ggaagatcaa gacggcatac aaggacggaa agttcaaatt caccgttacc cgcaatattg 2810161 aaggtcgtct atctgaggac tggaatccca atgaagactc gtttaaggat tcatatatta 2810221 aaagtattga aaagacagtc gaaaaacgag tacacgaaac agtaacgtca tttattacag 2810281 agaagctgca gaaagagatc aaagcggacg taaccgggct gggaaacgag gtcagaattc 2810341 attatcctca aaagtggaaa aagatttcaa gaaaatggga tgatgattat ttcagcaatg 2810401 cggaaataga ctaccgggtc aatgtgattg tcagagactt cggaacgaaa ggcgcaaaca 2810461 aatagcagcc gcctaattca cgagatgatt tcggtgtgcg tacaccgccg cctgcgtccg 2810521 gtcactgaca tccagctttg ataaaatatt cgtaatatgt gttttgactg ttttaatcgt 2810581 aataaacagt tcctcgccta tttctttgtt tgtctttcct tctgcgatca ggcagagtat 2810641 ttcgagctcc cgttttgtaa gcgattcatg cgggagcgcg ttttcacctg agtggcgcag 2810701 cctggataat acttttcccg ccacttttga ctccagcttc ggctctccct tgcttgcggc 2810761 gcggatggca tcggcgattt ctgccgcttt tgaggttttc aacagatagc tgagcgcgcc 2810821 agcttcaata accgggtaca ctttgtcatc atcaatgaag ctagtgagca caataatttt 2810881 cgggtcggaa agctcccggc aaatttgctt tgtagcttca atgccatcca tgccctccat 2810941 gacaaggtcc attaaaatga catcaggcga cagttccaca gcaagccgaa caccttcgct 2811001 gccgtccgat gcttcgccga tgacttcaat atcgggctgc gcctccaaaa aagccgcgag 2811061 ccccattctg accatttcat gatcatcaat caataatact cgaatcacgt tcgttctctc 2811121 ctttttcttc cggaaaaatc gggaccttca cttcgatttg agtgcctttt ccttctactg 2811181 aaatcacttc ggcgacaccg ccgatttcac ttgcacgttc tttcatagaa ttcaagccgt 2811241 atgaggaggc tttcacctgg tccattttaa agccttttcc attatcaatc accttcagac 2811301 ggagctggct gttctttatg cccagaatca cggttacttt tgacgctttt gaatgtctaa 2811361 atacgtttga aagggcctcc tgcacgattc tgaacaagtg gtcttcaaca cccttggata 2811421 tcgctgtgtc ctgtatatcc cactcaatat caatcggctg cttttttcgg aactcgtcca 2811481 aaagctccgt aaggccctcc ttcagccctt ttccttcaag ggtaacaggc cgtaaatgga 2811541 gcagcagcgc cctcatctca ttttgggctt cgcctgccat atgctcgacc atcctgatcc 2811601 gcttgactgt tttgtcatca gcatccttga catgttccag cacggctgat gtcatcatcg 2811661 atatggcaaa gagctgctgg ctgaccgcat catgaagatc tctggccaat cgctggcgtt 2811721 cttctgagat aaccgacttc ttcatttgag cctgccattc cgcacgttca ttggaaagtt 2811781 tctggaggga tgcgacttga agctccacgc gcttcgccat ttcgttcagc tgatcagcag 2811841 ccaggccgat ttcatcatca ccgagcggcg gtatccgata agcgaaattg ccgttttcaa 2811901 aggttaaaat ggattcaatt aatgtatcaa tccttgtctt caaccggttg ccgtacatat 2811961 accctgaggc gaaaccgacg gtcacgctga tcagaagcaa aatcaggata aacggaattc 2812021 cgaaccagct tgatgacagc aaaacaagcg gatcgagccg atagtaaaac atcataaagg 2812081 aaatcaggca aacaaaaagg agcaggctga ttcccgttgt catgcggatg gcgcgccatt 2812141 ggaggctggc aagcattttt tttctcatac gtacttcaca tccacatcac cgataaataa 2812201 ggaaacggac acttttaccc ggcgctttga ctcgctaaaa tcagttgacg cggcatatac 2812261 cttcgtgctt aatccgcttt tcttcgagcc gatcagatta atgtctccta taaaaacagc 2812321 cgagctgaca gccacttcaa ggtccgatgg tacataaata tcaacgttac caatgactcc 2812381 gctaatgacg attgtacttt ctccctcggg aatcatcgct ttagataaat cgattttgat 2812441 atcaccgata aaaccagaga catttaaatc gttcaggtca aacggctgct tcatcatttg 2812501 cagctcaccg ataaaaaagc tgcgcatgtc gggatgtttt acatcttttg gcggctcatg 2812561 atgttctttt ttattgagat tgacctgttt ctcattcggt tcaaatatcg gcttcccttt 2812621 gataagcctg tagccggcgt aaatcagaaa tgcggcaaac gcatagccga ataaattaaa 2812681 ggtgatgctg aagaggtttt tcaaaaatag aaacgcggca aagatataca tgacggagcc 2812741 aagccaatca cgggaatatt ttttaaggaa atagccggca atcagaaaaa agagcggcca 2812801 aaacagcaga tcgcctattc cgataatttg caaaaacata ctgatgccga ataaagcaat 2812861 gatcaatccg agaagctgtt tttttgtcat tcctggtgtc cgcctccttt cttctgccta 2812921 gtgctaccgt atcgctagat ccccgctgtc cgttttgatg tcgattggat gccggccgct 2812981 tccttgcgtg cctgtgatgt gatgctgttc tttatgtcct ttatcagcaa atgaatacgg 2813041 cgaactgacg tcaccgcttg ctgataaagc attgactgca aagctgccat tttggggaag 2813101 gcttacatta gcatcaccgc ttgtcagcgt gacagatacg ggaccggtta cctttttcaa 2813161 tacagcatta aaatctcctg aagtcatttt cacatcaaga gagcctgata catgaaccag 2813221 atttgcgtcc cctgaagcta aatcaatgcc ggctgttttg gagacggtat ttgaaatgga 2813281 aacatccccc gatgatgcct tcactttcag atcttgaatg cggacgtccg tcacgctcgt 2813341 atttccgctc gcagatactg cgttcagccc ggaaagcgca agatggtcat tcccggccac 2813401 agacacgtca ccgcttgagg ttcgtactgc cagatcacct ttataatcat acggaagcct 2813461 gacgataaga gttgaacggt taaatccatt caaaaattga aattcttttt cctttacggt 2813521 cagctccagt tttcttttgt tttcagtaac aaataacttt cctgagtctc ctgaaatgcc 2813581 tgccgatatg tcacttcgtt cttccgctat aatccggaca tccttgctat ccgactcaat 2813641 gaccatgctg tcaatgtccc gcggcgatgc gctggctgaa tcagcttctg tgccatttat 2813701 gaaacctagg cctgcagcaa acacatcttt tacgacgacg gcgaaaaaaa ccagaatacc 2813761 ggcagtgatc aacagtttgc caagcatttt tttcattcgg tttcatcctt ctcattcatt 2813821 ctattataaa ggaaaagctt gcgaattgat acgtgcggaa gggaaggact tgaccgcaaa 2813881 tccttccccg ttccgcttat tcatttgccg cttttgtctg gtctgatttt tgcagtgaaa 2813941 gtgtccgcat tttttcaatc tccgcttcca catcgtctgc gaattcttta cgtgtaagtt 2814001 ctgtgccggc ttccgctgac tttgaataat tcgcgcggat ttccatttct tcaatacgat 2814061 tttcaatacg taaaaattca cgatacgcgc tttcactgtc aattttgtca aatgtcgtat 2814121 tcatatgctc tttagctttc gccgcatttg cccgcgcaat cagcgcctgt tttttatcct 2814181 ttacgtcctg aagctttgtt tcaagtgcag ccagctgctc tttcagatca gccagctgac 2814241 tgtttgcctg ttcataggaa gctttatgct cagccgcctt cccttctaaa tacttcattt 2814301 cagtcagcgc ctttttcgcc agttcttctt cacctgcgtc aaatgcgagc tgtgcctgat 2814361 ttttccgttt gccagccact tcagcggctt cttcatattt tttcttaaat tgataggcaa 2814421 tcgtgtgctg tttcacaatt gtttgctttg cttttgcgat gtcgctttcc atatcgcgta 2814481 catattgatt cagcatcacc tttggattct ccattttatc aagtccttca tgaactgacg 2814541 caacaaacat gtctctgatt ctttttaata ccatacctga ttcctcctaa tatattgata 2814601 ttattttttc ttcaaaaatt cttcccattc gtcatcaaag tgagattggt aggcagcaga 2814661 agccggttca ggatcaaaag atgatacacc gttatcagct gatccgtttt tcatcagctt 2814721 ccagccgtaa tacaccatag cggccgccaa tgcgattccg acgacaaacg gaagtgagca 2814781 gatgagcata atggctccga taccgcccac gatgattccc gtgatggttt ttcccgcggc 2814841 aaaccttttg attcctgcgt atgtcatcaa gctcccgatg gcgagcggga tgataaagcc 2814901 gaagcttcct cctccaaaaa agacggagat cccaaataca attaataaga atccgcctat 2814961 tgttttcttg tttattttca tgcagatcct cctttcgttt tccttgtctt catcttatac 2815021 aagttggaag atatgcaaaa cgaatcagag attgattttt atataagacc ggagtcgtat 2815081 ctcgcaccgg acccattggc acaaaaaaac gccatgcacg aggcatggcg ttttaaaacc 2815141 ctttacagat gaacacttgc ttccctttct ttaattaggt cggacctttc tgctttggcc 2815201 aattttgtaa acagcaagat tccgataccc gcaataattt cgacaatccc accgacagcg 2815261 atcactttac ctgagccgaa agcattagcg gcatacccgc aaatgacagc tccggcaggg 2815321 atcgaaatat ttgagatcat atgtataacg gcgtaaacct gcggctgatc ctcactatcc 2815381 acagacgtct ggataatcgt gtactcagga acattaacag cactgactgc ggcaccaaag 2815441 gtaaaagcag cgaaaaagac gagcggcaaa aaggtattca tcccggtaat aaagaaagca 2815501 aatccttcaa taatgccggc agtgacgaat aacaagccgt acctgtttac cttgactttc 2815561 gccagcacaa accctaataa aaacgcgccc gcggcggtgg tggcctttaa aagcgagtat 2815621 acgatcggct ggccgtttaa atcttccgca acgtatacgg cagagagcgc ttcccatggg 2815681 gcagccgcga aattcataaa gatacagtaa atggcgagcg gatataaaat ctggtgtttt 2815741 ctgacgagcc taaagccgcg tttcagtctt ccgatatatg tgcctctctg tgtaacaacc 2815801 gcagactctg attgagattc aaccgcagtg tacttaataa aaagaacgag aaaacctgac 2815861 accaaataga gcacaagtgc gataagcatg gtataagaag gactaataaa tgtaagaaaa 2815921 gcgccgcata atgtgacagc cccaagccgg acaatttgag cggaggattg cagcacagcg 2815981 tttgcttttt gaatgccctg ttcattgacg atttgaggaa tcaaagcgat agaggcggga 2816041 ttgtaggcag ctccagtagc tgaatgcaca atcataagcg tcatgacaaa ccacagcgga 2816101 gagaagcccg caaaatgaca tagagggata atcaaaacaa tcgccgccct tgtcagatct 2816161 gaaaagtaca tccaaaattt cagcgtggtc tgtttcataa aaggccccgt cacaggcgcc 2816221 agaacggctt ccggcaaaaa cgtgacagca atcaataaag cagtgccgat cgcacctttg 2816281 ccgtcataaa ttaaaaacca taatattgaa ttaaatgcga acatatcgcc ggatatcttg 2816341 actattcttg agaaaaacag ataattgaaa tttctcttcc agatgctatc actttcaatt 2816401 aaattcacca tccatcagag ccccccgttg cctatttttt acatctattt attacaatat 2816461 ctcatttttc catttttcag tcaataattc ataaggttca ttttttgtcg taaaatggga 2816521 aattgacaga gtgaaaaaca aaaaaagccg gcatgtattt gaacacgccg gctttccttt 2816581 tcacttttta tgattcgctg ctgtttcggt cccgaaacac aatggcactt ctttcatatt 2816641 ctacatcgcc aataccgctt cttgcattca caacccgggc ggcggcaaag aaataatcgg 2816701 acagacgatt gagataacgc agcactgttt catgaatctc ctccgatttc atcagcgcca 2816761 ccactcttcg ttctgcccgc cttgtaatgg tgcgtgcgat atggagaagc gaagcacact 2816821 ttgatccgcc tggaagaata aatttcttca gttccggcgc ttctgctgta taggcatcaa 2816881 tgcgcgtttc taaaaaggaa acagattctt ccgttagttt atagtctttt ctttctgtga 2816941 cgattgccag atcgcctccg cagtcaaaca gctcatgctg gatggtcagc agctcggctg 2817001 tcagatcttc aaagccgggc tgcccggaaa gctctgccaa agcaagcccg ataaagctgt 2817061 taagctcgtc aatcgtgccg tagctttcga cgcgtaggct gtccttgtcc gttctgcccc 2817121 cgactaagcc cgtttgtccc ttatcgcctg tttttgtata tagtttcata ccctgaatct 2817181 cctttacaga cttattcaaa caactcagca gcctctttta tacattcagc tgtccctttc 2817241 tttatcaatt ggttcagccg ctgttctatg ttttctgatt gctgagtttg agtcgcggcg 2817301 atgagaatat cacctgtgcc tcctccgtct cccagcactt tcgtccgttc tgcttcggca 2817361 gccataagag ctttgatgaa gaattgatct gccgcatagc cgttaatcaa aatccaaatc 2817421 gaaaagccgg tctgaacgca tatgaaaacg gataactctc cgtcttcata tgttcgatac 2817481 acgaaacggt caagtctttc tgaagaagcc atcgcacacg tctcctgcag ttgaaaaccg 2817541 ctttctgaaa gacaggccgt aagtccttct atcggatctg gctgatctgg cagccgttta 2817601 tggatcagcg tcctgctcca cgaaaaccct gcaccgatag gcgtggagga caatgttcga 2817661 agcgggattt ccgtttgcag aagaatgtca tcacgccccg cttggagcaa tgcttcaaat 2817721 gggatagact gccgcttcac gctatctttt tcaggctgaa tcacaatcat cggtttaggt 2817781 gagctttgat gaaccaaggc ggtgacatct gtatcgtaca ccgcctttat gctttgttct 2817841 gtaacagcat attccggttt ttgcttaggc ccggcggtac cgtttttcat aaacatgagc 2817901 ccatcacagt acaggcttgc ggtgttcaga tcatgaaaaa cgctgacagc tgccaatccg 2817961 ctttctctcg tcaggcgttt gatcagatca agcaggtctt tttgataagc cagatcgaga 2818021 aaattagtcg gctcgtccaa aaataaaata cgcggctgct gcgccaaagc ttgtgccaaa 2818081 tacacccgct gctgttcccc tccgcttagt tcgcgaatcg gcttttgcgc aaaatcggcc 2818141 actcctgttt gctccattgc ttcctgtaca atggcttcac ccttttcagt ctgctgtctg 2818201 aacagccccg tttggaatgg atatctgcca aaggctacag tttcttcgac agtaaaggtg 2818261 aaggcttgat ccattttttg cggcaggaca gccatgattt gcgccagttc cttcggttta 2818321 tagtccgcca gcagttttcc ggccagataa accctgcctt tcttggccgg cagcgtacct 2818381 gtcagcaagt gcaaaagcgt ggtttttccg cttccattag ggccgagaat tccaagaaat 2818441 tctcccttct ccactgttaa gctgacattg ttgattaggc ggctgtcgcc gtatcctccc 2818501 gacagccctt ctgccttcat cataagcttc tccccccgcg atgctgccga attaaaataa 2818561 gagcgaacac aggcgctccc gccaaggacg taatgatccc gatcggcagt tcaatcggct 2818621 caatgatggt tctggaaagc agatcggcta aaacaagaaa ccctgcccca agcaaggcgg 2818681 acaacggcag taaatgccga tggtccgttc cccacaaaag ccttgtgata tgcggaatca 2818741 caaggccgac aaagccaatc gtacccgata ctgccacagc gcttcccgtc aaaagagatc 2818801 cggctattaa aatcatcatc ttcctctgct gaacgctgac tccaagaagc tttgctttat 2818861 cttctccata tgtcatcacg ttcagttccc ttccgtttat aatcaataaa atggttccca 2818921 aaagaaaaaa cgggagaaac aaaataacat agctccagcc cctcattgag acgctgccaa 2818981 gcagccaatg cacaatcgga agcaggttgt ctcctgtcaa ggcgatgata agagaaataa 2819041 atgcgcctaa aaaagagttg gtgatgacac cggtcaaaat gagggtggaa acagacatcg 2819101 aagcatgaac gaggcggctg aagaaaagga ccgccgccat cgtggccagt gccgcggcta 2819161 cactcaaaac cgggagtgta aaccctccga tgacaggaag gtgcaaacct aagaacagag 2819221 tcacaacagc tccgactgaa gcaccggatg acacacctag cgtataggga tcagcaagcg 2819281 gatttttcaa caatccttga aaagcggccc ctgcaataga aagagccgcc cccacaaggg 2819341 cggccagcac aactctcggc agtctgatat tcatcataat attagtgtac atcggatcat 2819401 cagaaccgat agagccgccg aaaccttgat gccaaaagac acgaaaaaca gcgggaatag 2819461 gaatatgcag gctgccgcaa gaaattccta agatgatgct cacggctaaa aatgagaaac 2819521 caatgatata tgcggcataa cgattattcc ttaaacgtat ccgggtaaat gctttccgca 2819581 agttcttcga ccccttcgat cagacgggga ccggaacgtg tcacaagatc agggtccaca 2819641 tcatatacac gatgatgttt cacagcattg atttcgctcc agccatcgcg tttttccaca 2819701 gctttcgctt tcacaccgtc cgttgtaaca attgcatcag gattgagttt tacgatcgcc 2819761 tcgtctgtca tttgcaccca tcctgtctga tccgcagctg cgtttttagc atggatgaca 2819821 tttagcattt cattcataaa cgtatctttt ccggttgtat aaatgtcagg atcaggagaa 2819881 acctcgataa atacgctttt ctcctcgtct tttgaaatgg ttttcgcttt ttcttgaata 2819941 tcctttagat ctgatttcat gcttttcacg agctgatcgg cttttttctc cgccccgcca 2820001 gcttctccga tcatttcgat tgatttgtac acctcggaga atgattgtgc atcattgaca 2820061 gtcagcactg taatgcccgc gtccttcagc tgtttgatgg catccgctga tgctgacatg 2820121 gaagactcat gggccagaac gagatctggt tttagagaaa tgactttttc aacgtttaca 2820181 ttcatatctc cgactttctc aacctttttg acttcctttg gataggtatc gtttgtggtg 2820241 acaccgacca ctttgtcacc aaggccgagt gcgtatgtaa tttctgtgtt gctcggcatt 2820301 aatgaaacaa tcttttttgg ctcttttttg atggttacat cttggtttga cgcatcatca 2820361 atggtgacag ggaacacttc tgttttttgt tttgcctttg aatccttctg atccgcagga 2820421 ttgccgcagc ctgccagcat aacagcagcc aacagaagcg cagcccatat cccggctcgt 2820481 tttttcataa tcttttcctc ctaaacgaac taaaaaagca tctctacgac ggtaaagatg 2820541 ctgtaaacaa cacaaaaaag cctattgttt acacatcatc tgtcctcgca gaattcgtgc 2820601 tgatcaaaca ggcaggtatc ctggctcttg gcgcttggcc aattacagtg gcgggaccgc 2820661 accggctttt accggtttcc cttttaagcc ggctgttgtt cacggaccgg cacctatttg 2820721 acattcgtat ccgtttttcg gagtaattat actatatgac tgacaggctt gtatatgtgt 2820781 cctgaatgac ttttccccat attgtgtatg gaagcaaaat cctcgtaaac actaaatttg 2820841 atcttgtata cttaatacca tcatctatca aaaggaatga ttcttatgga tttacagcta 2820901 aaagaaaaac tcgtcttaat caccggctcg acgtccggta tcgggaaagc cgccgcaaaa 2820961 agctttctgc aagagggtgc ggcagtcatt gtcaacggac gcaaacagga gactgtcgat 2821021 cgcaccattg aagagctttc tggctatgga acagtgcacg gtgctgctgc cgatttgtca 2821081 aaaacagatg aagcagcggc ttttatcgaa aaagtaaatg aaatcggtga tatcgatatc 2821141 cttgtcaaca accttggttt cttcgaggta aaagacttcg ccgatgtgac agatgaagag 2821201 tggaatcaat atttcgaagt gaacgtgatg agcgccgttc ggacaagccg tcacttcctt 2821261 ccaaaaatgc ttgccaaaaa cagcggccgc attttaaata ttgcaagtga agcaggcgtc 2821321 aaaccgctgc caacgatgat tccatactca atgacaaaaa cggcactgat cagcctttca 2821381 agaggaatgg ctgaaatgac aaaaggcaca aatgtgacgg tcaactcagt gctcccggga 2821441 cctacttgga cagagggcgt ggcctcctat atggaaggcg ccgcacaagc agccggacag 2821501 gatacagata catttatcaa agactatttc aaggtcaatg agccaacctc acttattcag 2821561 cgatacgcga cagcagaaga agtcgccaac acaatcgtat tcctcgcgtc tgacgccgca 2821621 tccgccatta acggcacggc acagcgtgtg gaaggcggca ttatccgttc tctgtagtat 2821681 aaaaaaacgc atccgtgttt cggatgcgtt ttttttatac gtctccagca aatggtaccg 2821741 gctgatatcc gcctgtttcc agttgtgctg aaaacaaccc tccagcgtga ggctgctcgt 2821801 atctctcttt ttctgtcatt tgttctgttg ccgttgtaat gtaaagggtt tttaagtctc 2821861 tgccgccgaa cgcgcagcac gtgacatatt tagccggcac gctgattgaa ttgatttctt 2821921 ttttctgaaa cgggtcaatg tgaacaacgc ggctgccgcc aaacagcgcc acccacagca 2821981 tgccattttg gtcaattgtc atgccgtccg gcaatccgtc tgactgatca aaacgataga 2822041 caggttctgg attcgaaaca tctccgcttt gaggatcata gctgtaacgt acaatctcct 2822101 gggtcggcgt gtcgatgtaa tacatcaaat tccgctcgcg gtcccaatcc aaaccgtttg 2822161 aggtggagac ttgatccttg attttgacaa gactgccgtc tagattcaaa cggtacagcg 2822221 acgcctgttt ttgctcgcct tccatgctcg tcgtccccgc ccaaagcctt ccgtacgggt 2822281 cacatttagc atcattaaat ctcaggctct catgcatgtc cttcggctgt ttaatttttt 2822341 ccaagctgtc atcccgaaga tgatacaggt aaaacccgtc cttcatcgtc ataatcagtt 2822401 catcctttga atatttcgca agcgccgtca caaaggattt gaatttgatt gatcggttga 2822461 ttttttcttc agggtcaaag atgtggagct cgctccccag gatatcaacc caatataagc 2822521 ggccgttctc ttcatcccat aacgggcctt caccaatcac tgcccgagtg tctgcttcca 2822581 atactgcatc catgtgttac acctctttag cttcagtcta tatattgtta ttcccggcaa 2822641 agaggtgtcc aaaccacttg atgtttattg ttttttaaaa aggatggtaa tgaccgttcc 2822701 aatgttcgtt ctgctgttca catggatcgt tccgttatgc agatggacaa gctccttggc 2822761 aatcgcgagc ccgagacccg ttccggcagt tgaatctttt gtgttcgtcc ctctgtagta 2822821 gcggttaaac aaatgggtga tcgtttcttc atccattcct ttcccattgt ccttcacttt 2822881 taaagaaata tgattttttg tttgctccag aatgacttga atctctgttc ctttgccgtt 2822941 gtgcttcacg gcattcccaa ggaggttttc taatatgcgc ctgaaccacg cttcatcaag 2823001 ggcaaattca atatgctctt ctttggatac aaacgagata tcatagcctt cagaaaacgg 2823061 atttttctta aaatcctcaa tgacattttt aaaaaacggg ataaggctag tgagctttct 2823121 ctcaatagga agagcatcat ttttcaggcg atacgttaaa tttaagtctt caatcagctt 2823181 agacatgtat tcagattttt ctctgacaac ctgccccatt tctttcactt cttccggcga 2823241 ccagtcatac tgcttcgact cgagcatcat gctgtagccg taaatgctgc tgagcggtgt 2823301 ttttaagtca tgtgacaaac cggcaatcca ttcttccctt gtcgcctgga ttttttctct 2823361 gtttctttta tcccttctca gcgtttcagt cagctgatcc attgattcaa atatctcacc 2823421 gaagaagcgg tacggctgtt tgatttttcc ctttttattt ttgctgacag gacggccttc 2823481 ccggtttctg ggctcctcaa gcttcccttt tgacagattg accagccatc taatcgtgtg 2823541 aaaaatcggc agcccgaatc ggaacatata ccaaacggtc atccaaatga tatacatgaa 2823601 caaaacggcc atcacgagaa acatcgcttt taatacaacc ttcaggaatg atttgttaaa 2823661 ctcctgatcg gttacataga ctgggttcgg caccgtagcg accatccatc tgtctttatt 2823721 gaggatctta acggaaattt cccgcttata gttccaaggc ttagagctgt atttaagcag 2823781 ctccagctgg ttcatcgttt ttctctcgct ttttgtgctg ttgatgctgt cgagaatctt 2823841 tccattgctg tctaacaggt aaatggcgcc ttttttccgt ttaatatagt cgatggtact 2823901 agacttatag tgcgctagtg agtctatctt ttgttcacgc ttttcaacgg aagtcaggag 2823961 ctgttcactt tttgatttcc agccggacaa tagaagatac gacttatctt caatattgat 2824021 ggcccaataa ttcagtttat agttatgaag ctttttggtt ttataaatag acaaaagctc 2824081 tttcttggta taggtgcccg gcacgtcttt tggcacgccg taggaataat cagtgtttcc 2824141 ttccgaatca atgatttgca tccagccgtg ctgtttatca acagatttct tcaggaaatt 2824201 atccacttcc catgtcccgt cttcgtttac atcgagatat gcctcaagtg tgtcggtcgt 2824261 tgctttcgtc agccctgaat tggattccgc atcgctaaaa cgggcgtcta aatagaaaaa 2824321 cgatgcaaca agcataaccg taagcagcag gatcacaatc agcatctggc cgaaaaagtg 2824381 aaacaaaaac ttccatctta acctcatgac cgcttgcctt caggatttgg gataaaacga 2824441 tagccgagac ctcgaacggt tacaatatac tccggattgc tcggatcgcg ctcaatcttc 2824501 tccctaagct tgcgaatatg aaccatgacg gtgttgttgt caccgtagga aggatagccc 2824561 catacttttt catatatttg atctttggaa agcaccacgt tagggtgttc acaaaaatac 2824621 tgcaaaagct gcagaagctg ggctgaacag gcaacggctt ccccgcctac gatcaactcg 2824681 gcattttgcg gagaaaaagt aaagtaatca tatgtgtagg tttgatttga actcgtttct 2824741 ttcgattgat atgtacgctt gagatgcgct ctgatccgcg ccgctaattc cagcggatta 2824801 aatggttttg tgatatagtc atcagctcca accgcaaagc ccgataattt gtccgcgtcg 2824861 gatgatcttg ccgtcaggaa aaaaatcgga gcgtctgaat actctctgat caatgtgcag 2824921 gcttcaaaac cggacattcc gcccatcatg acatccagca caatcaagtc aaccttattg 2824981 gccttcacaa cgggaatcgc ttcttctgcg cttgccgcat ccagtatatt tcgataacct 2825041 tctttttcga gaacgcgttt gatcatgtcc acaatcgctt tctcatcgtc tacgattaaa 2825101 attgacgcat tttccacttt tatgttcctt tctgtcactg tttttttcat cttatcatta 2825161 tatcgtttat ttatggtaca tttttgaata cattggagcc ttggcaaatc aaaacagcaa 2825221 aaaaggagca aacaagcgct cccttttgat gttttttcat atgaaaatat tatgagttct 2825281 catctaccat gtacaaaata aactcccaaa accccggtac atcctgacat aaaagcatat 2825341 cagccttttc aaacattttg atcttcagct cttgctctaa atcttctctt tcttgatagg 2825401 acgtattgct gagttttttt ctgatcatcg gtgaaaagca tgcaatcagg tgctcaatgt 2825461 cataagtctc gtctttttgt ttcttttttt gttcaaactg gccgtccaca gcttactttt 2825521 cccccttttt ttgcgccgct aactgctttc tgatattctc cagccccttt ttatgaatgt 2825581 tggagatgtt ttgtcgggac tcccctaatg aatctgcaat ctcctgcatc gtggcaccgt 2825641 gaagatagac tttcgtcagc acactttttt gtttgtcagt cagcttctgg atcgcttggt 2825701 agagctggta atcctgtaca tgctggctca aatcatcctg cctgtctaaa aattcttcaa 2825761 atgcatcgct acctgtttcg gaagaaagcc gatctcccgc ctccggatga tcaaccgtca 2825821 gtggataccg tttttggttt ttgcgaaccc gcttatcaaa atcaatagaa aagatgcgaa 2825881 tcattgaatt catatacttg acgatgcgga tttctttata aaattgctta aatagctcgt 2825941 ccaatgatct tgcatctttt tcgttagggc tttccattac gtttttgaac aaacggtaat 2826001 gctgaggatt gctcaaaaaa tgcttcacga tgggatgctt cattatctcc ttacattttg 2826061 accgtaaaag actttgatag tccatcaaac cgcctcccta ctaaattaaa tgaaggaaag 2826121 caaaaaaaag taaactacta ctttccgcct agtgtcttcc aaaatacttt gcagcagttt 2826181 acgttttatc ggttttcctc acttacatac atgactgcag aaaaagaagg gaggtatttt 2826241 cctatggatc aggtttttat agaggaagtc gtaaaacaga tcggcaattt ggggtttccc 2826301 gcgctgattg caatgtatct gctgacccga ttcgaaaaga agtttgatca actaatagaa 2826361 ctaatgacag aactgaaaga tcatgcaaaa aaataatttt tcaatcgaag ttgacttttc 2826421 actggttttt ttcacttaac aaaacagaag ggaaaacgaa aggcctttca ccttctcttt 2826481 ctgctatcac atttaaatgt aaggaggaaa catttcatga aaaaacaaaa tgacattccg 2826541 cagccaatta gaggagacaa aggagcaacg gtaaaaatcc cgcgcaatat tgaaagagac 2826601 cggcaaaacc ctgatatgct cgttccgcct gaaaccgatc atggcaccgt cagcaatatg 2826661 aagttttcat tctctgatac tcataaccga ttagaaaaag gcggatatgc ccgggaagtg 2826721 acagtacgtg aattgccgat ttcagaaaac cttgcatccg taaatatgcg gctgaagcca 2826781 ggcgcgattc gcgagcttca ctggcataaa gaagctgaat gggcttatat gatttacgga 2826841 agtgcaagag tcacaattgt agatgaaaaa gggcgcagct ttattgacga tgtaggtgaa 2826901 ggagaccttt ggtacttccc gtcaggcctg ccgcactcca tccaagcgct ggaggaggga 2826961 gctgagttcc tgctcgtgtt tgacgatgga tcattctctg aaaacagcac gttccagctg 2827021 acagattggc tggcccacac tccaaaagaa gtcattgctg cgaacttcgg cgtgacaaaa 2827081 gaagagattt ccaatttgcc tggcaaagaa aaatatatat ttgaaaacca acttcctggc 2827141 agtttaaaag atgatattgt ggaagggccg aatggcgaag tgccttatcc atttacttac 2827201 cgccttcttg aacaagagcc gatcgaatct gagggaggaa aagtatacat tgcagattcg 2827261 acaaacttca aagtgtctaa aaccatcgca tcagcgctcg taacagtaga acccggcgcc 2827321 atgagagaac tgcactggca cccgaatacc cacgaatggc aatactacat ctccggtaaa 2827381 gctagaatga ccgtttttgc atctgacggc catgccagaa cgtttaatta ccaagccggt 2827441 gatgtcggat atgtaccatt tgcaatgggt cattacgttg aaaacatcgg ggatgaaccg 2827501 cttgtctttt tagaaatctt caaagacgac cattatgctg atgtatcttt aaaccaatgg 2827561 cttgccatgc ttcctgaaac atttgttcaa gcgcaccttg acttgggcaa agactttact 2827621 gatgtgcttt caaaagaaaa gcacccagta gtgaaaaaga aatgcagtaa ataaaagact 2827681 tgcggcttgc agagagcact cgttctctgc aagccttcat aaggagctga accagtgaaa 2827741 catcaaaacc cttcaaaacg cttattgcgg ctctccataa agtacttgct ggccgcagca 2827801 gcagtggtgt tgacctattt tgctgtcatc tatatattgt tttctttagc gggaacgagc 2827861 taccgctcag cagctcatgt cctgcttttt gccgtggtat tccttgttct cggattatgc 2827921 tttgaaccat ttgaacggct gatgatacat agctttacat ttttcaagac aggaaaacgt 2827981 ctattcattc tccttgctgg catcgtacag ctgctgtttt tgtggatgac tgctcataca 2828041 acagaccaat tgatcagcga catctggctg tccaccacag aagaaatgat tgtcgcagcc 2828101 gtttttttga ttttagacaa atgcaactcg gctcttccca gctaaaaaaa gaacgcattc 2828161 caattggatg cgttcttttt attcatagcg aagcgcgtct acaggctgaa gcttcgaagc 2828221 cttgatagac ggaagcaagc cgaagataat gccgactgcc attgaaaaga tgagtgctcc 2828281 gacaacagct ggaatggaga cgataaaagg catcggaaaa atgaccgtca gcagcttggc 2828341 gatgccgaag cccgccagca caccgagtat tccgccaatg cttgtcagca cgacagcctc 2828401 ggttaaaaat tgaaataaaa tcacacgccg cttagcaccg agcgctttct taattccgat 2828461 ttccctcgtg cgctccgtta cggaaacgag cataatgttc atgacgccga taccgcccac 2828521 caaaagtgaa atactggcga taccgccaag cagcaatgca aatgactgat taaaggactc 2828581 cacttcctgc gcgatctcct gaagatccat tacactgtac tctgcttttt ccagctcagc 2828641 ttctgacagt ccctgattta aaagatctgc agccattaca cccgcttctt ggatatgctc 2828701 agaagaatca gcctgcacgg caatctgcgt tggcgcgtca aatccttcaa taagcggcca 2828761 cacttttttc ggcacgtaca aaaccgggtt cgcatagtcg ccttcaaaca tgctttcctg 2828821 ttgatttttt tctttaaaaa cacccacgac cttaaacggc acaccattca tctcaatgct 2828881 tttatgcaga gcttctccgt ctggaaacag ttcatctctg acagcttcat tgatcatcac 2828941 tacttggtgt gtgctgttta aatcgttttc cgtcagcttt ctcccttcgg ttattcggat 2829001 tggaaacatg tcgaagtaat catcgtccac tccatacact tggggatacg aaacgttagt 2829061 taaatgaaaa acgctcgcgc cttctgacaa gtaatataag gataatcctt tgaccatcgg 2829121 atctgatttg atcgccttta ctgtttcttc cgctacaggc ggcgcggacg catacgacac 2829181 ctgagggccg ccgctctcct cttctccgcc agacggctgg tagacaacat tgatggcgtt 2829241 gtttcccatg ccgatcatac tttgctttaa ctgctcactt tggcccttca gcattgaaac 2829301 aatcgcgatg attgccgcta tgccgataat gacgccaagc attgtcagaa tcgatcttaa 2829361 tttatgagag aaaatggatt gaaaggagat tcgaatatgt tcaagcatgg ctgatatccc 2829421 ctctctcatc taataccaac tctccgtctc tgataaaaac ggttctgtca gcttttttgg 2829481 cgacgtccgg gtcgtgggtt atcataataa tggtcttgcc ttcccgatgc agttcagaaa 2829541 acagtgccaa aatttgttca cttgatttgg tatcaagcgc cccggtcggt tcatcagcta 2829601 aaataaacct cggctgattg acaagggccc tcgctatcgc cacccgctgc ttttggccgc 2829661 cggacagctt aggcggtttg taggagaccc tgtcttttaa tccgactttt tccagcgctt 2829721 catatgcccg ttgccttctc tcttttttct tcactttatt gtagatcatc ggcagctcga 2829781 cattttgcag cgcggtgaga cgcggcagca aatgaaaagt ttgaaacaca aacccgattg 2829841 attcattgcg aatttcggct aaagccccgt ctttcccttt caatatatcg atctggtcaa 2829901 gcgtataggt tcctgaggtt ggcctgtcca aacagccgat aatattcatt aacgttgact 2829961 ttccagaacc ggaaggcccc ataatagcta aaaactcccc cgcctgaacg gtcagattga 2830021 tatgtttcaa gattggaact tcttcttttc ccagcttgta cgacttcgaa atattattca 2830081 gtgtcagcat tgactgtaac ctgctttcct tccttgaccg cgggatcagg atagatcaca 2830141 taatcttccg gcgtcaggcc gctcttaatt tccaccatgt cattttcatc agtctctccg 2830201 atttcaacag gctgcttaac cgctttgtga ttctcatcag ctttccatac gtacggttcg 2830261 ccgtcatcct gaatgaccat gtcggacggc agcttgatcg tgtccgcatc agcattatca 2830321 ctcatcactt cgatgttgac atgatagccg acttcaagac ctttatggct gtctaataaa 2830381 atggtgaaag gatagttaga ggactgggga ttcatttctt catcagcaaa gctttctgat 2830441 tcttcaccct cgcctgctcc cgctggaagc ttgccgatcg aggtgacctt tcctttccac 2830501 tcgccctcac cgcctgtttt cagcgtgacc ctgactttgc tgcctttttt gatcgtgtcc 2830561 attaacagct cattgatttg gcttttgacc agatatttgc ctgtcgaaac aatctggata 2830621 tacgggcctg ctgcctggtc gcctgttgca ccgtcagcga tatcctgatt gacgctttga 2830681 acgattccgt catgcttgct tgtaatgaca ttggaacctt tgtttttcgt caggccagcc 2830741 agttcttttt gatgctgctt cagttcaagc tggcttgttt tcaaatcgaa attggtttga 2830801 tcaagttcat cttgaagctg gtttttctct tcttttcctg caactttcag ctttttttcc 2830861 gtttccgtta ttgatttttg caaacggttg atttgcagat ttgtcatttc aatttgcaaa 2830921 ttggcttgct ccacttcatc agaatgatcc tcgccctcat actcaaaaag cttatcgccc 2830981 tttttaacct gatcgccttc tttgacgtat gtttttttaa tgctgccttt ttctgaatct 2831041 atgtatactt tctgctgttt ctcaggttca acctttccag aaaacgtttg gcctgattct 2831101 gaatctcctc ccatgtatac cgcgaccgat tcagcatagg gctccgatga tacggcaact 2831161 tggttcatgt gagtaaaaaa gtaaaaaccg ccagcgccga tcccagccaa tacaagcaca 2831221 ccggcacata tcgcaccgcc aataagccat tttttcttct tggacacaac gatctcctct 2831281 ttctgtaaac tatgtaatat tttcgaaaca ttctaaccaa tattatctat taattcaaaa 2831341 agacttgcaa tccttttatt gaaatgacgg aatcaaatag aaaaattgta ttttcaaagc 2831401 cgaataaaaa aaatcccggc ttcaaaccgg gattttttca tacagtaact agctcttttt 2831461 catttttaat caagtcatat gtcaagcata caggtttatt tgtacgggga tcagtcacga 2831521 tttcggcatc aatctgaaat acctgcttca aaatgtctgg tgtcatgacc tccagagcag 2831581 ttccttcctt gatgaccgtg ccttttttga gcgcgatcat ataatgagaa aaacgagctg 2831641 catggttaag atcatgaatg accattaaaa tcgtccgccc ttgctctttg ttgagtctgt 2831701 caagcagctg cagaatttca agctgatgtg caagatcaag atacgttgta ggttcatcca 2831761 gcagaagcag ttccgtccct tgcgcaagcg ccatggcaat ccacacacgt tgacgctgtc 2831821 cgcctgacaa tgcctcaatc ggccgttcag catattcagc catgcctgtt tcttcaagcg 2831881 cccatttgat aatccggcgg tcttcgtcat ttaatctgcc gaatcctgat tgatgcggaa 2831941 acctgccgta cgacaccaat tcgtgcactg ttaggccgct cggcgcttca ggtgtctgtg 2832001 gaagaatcgc catatctttt gcaatgtcct ttgtagacat tttatgaatc gctttgccgt 2832061 ttaaatagac ggcacctgca tgtgaacgca taattctgga cattgttttt aaaatcgttg 2832121 atttcccgca gccgttcggg ccaattaagg tggtaatttt ccctttagga atcgatatat 2832181 ttaaatcctc tacaatcacc ctgtcgccat aaccgattcc aagctgttcc gttgataatg 2832241 aattcatatt cggccccctc ctctaattcg ctttcatcaa taaataaata aagtaaggcg 2832301 cacctagcac ggaaatgaca agtccgaccg gaatttctga tggtgccaat acatttctcg 2832361 ccagcgtatc agcaagcaaa aacaggaatg agccgatgaa ggcggagacc ggtatcagcg 2832421 tctggtgacg tggaccggtc agccttctag ccacatgcgg cgcgatcaat ccgagaaacg 2832481 caatgccccc cgcagctgcc acgcatgaag cggcaagagt gaccgctgcc agaagaagaa 2832541 tccgtctttc cttttcaaca gcggtgccca gcccggtcgc caattggtct ccgagctgca 2832601 taatgttcaa atagcgtgcc ttatataaag taaacagaag caagatcaca atccaaggga 2832661 gaatcgccca gatcatattc cagttcgccc cccatattga gccggatatc caaaccgcgg 2832721 cttgcataaa atcatgaggg tccatcttga gctgaaaaat cagcaacagg gcgttgaatc 2832781 cggcattcac ccctatgccg actaaaatca gccgaatcgg tgtcacgcct tttttccatg 2832841 ccagaatata aatgagaaac gcagcgagga ttgctcctgc caaagcactg aacggcagca 2832901 taaatgttcc gaaaaagcta agatctgaag ctgacccttg aaaaaagtat ataaaaagca 2832961 ctacagcaag tgaaccgccg gcgttaattc cgagaatacc aggctcggca agttcatttt 2833021 gagacacgct ttgcaaaatg gctccagcta cggagatccc tgctccaaca agcaaagaaa 2833081 ggatgatccg gggcagcctg aactcaaata agacaagttc atcacgcgcc gttccttggc 2833141 cgaaaaagac ctgaagcgtt ttaagcggtg caattttgat aacgcccaaa ttgagactga 2833201 taaaaaagac caccacgata agcaaaaagg tcacagccat tacaatgagc ggtttgtttg 2833261 tttttgtttt cattacagcc ctctcctttc acgacgtgcc aaataaaaga aaaagggaac 2833321 gccgataaga gaagtcagcg cgccgacagg cgtttcaaag ggcgcattta cgagtctggc 2833381 cgctatgtca gcaaaaacaa gcaaaacagc accgagcacc gccgagcaag gaatgatcca 2833441 ccgataatcc acaccgacca aaaaacgggt aatatgcgga atgatcagcc cgataaatgc 2833501 aatggtgccg gcaatggaaa ccgcagctcc ggtcagaatt actacaataa gcatgccaac 2833561 cagtttcacc gctgatgtat attgtccaag cccttttgcc agatcgtcac cgagacttaa 2833621 cactgtaaca gaccgggcga tgaaaaacgc gagcgttaaa ccgacagccc ctgcaataag 2833681 caaaagctgg acccccgacc atttcacacc cgctaccccg cctgcgtacc aaaagctgat 2833741 atcctgagcg acatcaaagc ggattgcaat ggcagttgaa atgccggtaa agaaataagt 2833801 aactgccgta cccgccagag caagctttac aggcgtaagt ccgccccttg aaaacatgcc 2833861 tatgcccatt accgtcgatg cccccagccc cgctcccgca aaggaccata gcacaagccc 2833921 cattgcagaa agtccgggaa aaaaggcaaa cgcaatcgaa accgcaaacg cagagcctga 2833981 tgtcacaccc ataatcgaag gctctgccaa agggtttctc gtcatcccct gcatgattgc 2834041 tcccgacact gccaacaatg cgcctacaag cgcggcagcc gccgttctcg gaagccgaag 2834101 atcatgtata atttggtgag atgtctttgt cggctgataa tgaaaaatgg cctcccatac 2834161 agtgcgcaaa tgaatatccg ctgcacctag ggatatggat aaaaatgcgc caaggcaaag 2834221 caggcataga cctgcgataa ggacgatgac cgcgccatat gtccttgacg tccattggat 2834281 ttcttctgat gcagtccgta tatttttatg ttgactcaac tgccgtactt cctttctgtt 2834341 actgataatg attatcaatt gctgtttcag tatatcactt ttttcagctg atttaataga 2834401 gtgttttgaa caaaaatgaa aatgcatttg caaaaatatc gtgtcaaccg gcacttgcag 2834461 tggtataatc acagatgata atgattctct ttttcatcta tcttttagaa agaaggtatg 2834521 agatatgacc catatataca agaaactcgg agccgcgttt tttgccctgt tattgattgc 2834581 agcgctggca gcctgcggga ataactcaga aagcaaaggt tctgcctctg attcaaaagg 2834641 cgcagaaacc tttacataca aggctgaaaa cggaaatgta aaaatcccga agcatcctaa 2834701 acgggtggtt gtcatggcag acggctatta cggctacttc aaaacactcg gcatcaacgt 2834761 tgtaggtgcg cctgagaatg tatttaaaaa cccttactac aaaggaaaaa ccaacggcgt 2834821 cgaaaacatc ggagacggca cttcggttga aaaggtcatt gatttgaacc ctgacctgat 2834881 tatcgtctgg acaacacagg gcgctgatat taaaaagctt gaaaaaattg cgccgactgt 2834941 cgcagtaaaa tacgataagc tcgacaacat cgaacagctg aaagaatttg caaaaatgac 2835001 gggaactgaa gataaagctg aaaaatggct ggccaagtgg gataaaaaag ttgcggccgc 2835061 taaaacaaaa atcaaaaaag cggtcggtga caaaaccatt tccattatgc aaacgaacgg 2835121 aaaagacatt tacgtatttg gtaaagactt tggaagaggc ggaagcatca tttacaaaga 2835181 cctcggcctg caggctacaa agctgacaaa agaaaaagcc attgaccagg ggccaggtta 2835241 tacaagtatt tcattagaga agctccctga cttcgccgga gattacattt tcgcgggccc 2835301 atggcaatca ggcggtgatg atggcggcgt ttttgaaagc tccatttgga agaacctgaa 2835361 tgccgttaaa aatggccatg tatacaagat ggatccgatc ggattctatt tcacagaccc 2835421 gatttcatta gaaggacaac tggagtttat tacggaaagc ttgactaaat aaacaaaaga 2835481 gccgcctgcc cgcggctctt ttgcttattt ataaggaacg gctcaatttg aatcatatcg 2835541 gatattttct ttgagccatt catattaagc tgcatcctca tcacgatcag tttttttatg 2835601 ctggagagac tgaaaaacgt tttttgcata tttaacgaac ggattcctaa caggagaaat 2835661 tgtgatttta taaaaaagac acctgagcaa atcaggtgtc ttttcattat gcttgttttt 2835721 ctttctggaa cttgttactc acaaatggat aaacgattaa gccgacaaag aataaaccga 2835781 tgccgagtat aaatgtcgtt aaatctgctg tgcctgttac gataacaaac acggagtatg 2835841 cacacgccag tatcgcgatc aatccgtctc ttacacggga gcctttcagc tggtcatacg 2835901 tttcaccttt gatgactacc ttcaagctgt agattgcaga taccagatac ggaattaaat 2835961 atgcgagtgt agccgctgtc gttaaaaatg taaatgcgtc acttattgtc cgggaaataa 2836021 ccgagaaaat gaagacctgt gacatgacgt ttgtaataat gagtgcaatg accggacttc 2836081 cctttttatt cgtttttgca aaaaatgccg ggaaatctcc tgctttagcg gcttggtatg 2836141 gcacctcaga gccaagcaaa atccagccga gcatcgttcc gaataaacaa aggatagcca 2836201 aaagcgccat aatcacgctt cccgcgtttc caacaatcgc atagagtaca tcaacaaatg 2836261 gtttttcaga gccgacaagc ttatcatgcg gcagaacacc catcgtaatt aaagtcacaa 2836321 taatatatat gctcaaggca atcagcaagc cggtaattgt cgcacgtttc acatcacgct 2836381 gagagcgcgc acggccggac aggatcaccg cggattcaat tccgacaaac gcccacagtg 2836441 tagaaatcgc agcgttatga acctggccac caattccaat gcttgtgccg ttttctcctt 2836501 gaaccgggaa ataaaaatga ccgaataatg acgtttgaaa cacaaacaaa ccggcaacga 2836561 taaagaagac aaaacctaat actttagaaa gcgttgtgac aaagtttaat ttacttgcgc 2836621 cgttaatgct ggcaacaaga atcgcgtgcg ttccccataa caagatcgta catacggcaa 2836681 acgtcagtaa ttggccgagt gtcacctctt gcccgccgat cgaaaacatc tcacgtttat 2836741 caaccaagat cgggaagaac gaagtcaagt aaccggcgag acttgtgatg atcgccacgt 2836801 tactgatcca gctcgccacc cagtagcccc acaccattgt gaaaccggca gcgttgcctt 2836861 ttttcgggtc agaaaacagc gctcttgcat aactttgcgg tcccgctgtc agttcaggct 2836921 tgcgaatgga caagtgtccg aacacaagtg caatcatcag cacgccggca cctgtcaaaa 2836981 gccaggcgga cgtagctcca aacggactcg caattgaagc aagcgagctc ggcaaggaga 2837041 aaattcctga tccaaccata tttccaacga caaacgccgt taataaccaa aaaccccatt 2837101 tttttgtctg ttccattcca gtacctccat gattctttgt acggaccaga ccccgagatc 2837161 atataaacgc aaaaaaagcc tgaacaaaag tccatgctta aagaaacaca cacccttgat 2837221 ctccggatag ccctccgcga aaaagcacgc ggcagtcctg cacttattca gatacagtcc 2837281 cagcatagag aaggatcggc tttctccaca cttcggcgct gatgcctttt acacatgttt 2837341 aacagcccct gtcagcctag catgtgtgac tcatcatccg cgcaacctct acctcactga 2837401 gaaagagtga ggatttaatt attcagttac tcccagaagg ttatcaaaga aaggatgatc 2837461 tgtcaaaggg aacagatgga aaatacggat agagccaagc cctatccgca tgtggttatc 2837521 gattattttt ctttttttgc acagcttctt gaagcggatc atcttttaga gctgaaccag 2837581 catcttcaag agctccttgg attacgtttt tttctttttc ggaacgtttt cctttatctt 2837641 tattaaagaa acccattcgt atcacctctt ttaaaaaata ggtacatgtt taagatgcct 2837701 ttttcctgaa aaattatgcg ggatattttt tatcgtccaa agtcctgttg atcaaacata 2837761 cattctcttg atatatttgt aattcagaga ttttttgcaa aagataaaag gagaagcggc 2837821 aaatgacagg aaaaacacac atcatgggag gcatcgcttc ttgtacggca gcggcttatt 2837881 attatggatt tgatccagtg cttatggctg cgtcaggcgc ggttggagca ttaatacccg 2837941 atatctgcca cacacaaagc aaaatcggga gaaaatttcc tattttatcg aaagtggtca 2838001 gctccgtttt tggccatcgc acctttacac acagcctgct gtttatgctc atcatgtttt 2838061 ttatcacttc tacatacatt ccagataaaa acatatcagc cggcctgatg atcggaatgg 2838121 cgagccactt gattcttgac gcttggacgg tgaacggaat caaattatta ttcccttcca 2838181 cgatccgcgt tcggcttcca ttatatatga agacaggcag tttttctgag cagctcgtgc 2838241 tagccggcct gacccttgct tcatgttact acttttatat gctgtttcat ggccgcatgt 2838301 tttaaacatg agtgctgaga cttgtctgaa ccggctgttt ttagtaggtt ttacttaaga 2838361 agcatttcat gcagatgatc aagaaaacgt gaggagtcat attgatgaaa ggaacctttt 2838421 ttcacaatca gcggttttta tgtttttcga tcttatttat gtggatcaaa acgtatgtga 2838481 tatataaact cggctttgat ttgcaaatcg atactctgtt ggaggagcta atgctgctgg 2838541 tcaacccgct cagctttatt cttcctttat tcgggatcgg cctgtttcta aaagaaaaca 2838601 agcagcgggc ctttttgctg attgccaatt tggttctgac tgttatcttg atctctaata 2838661 cgatttttta cggcttttat atcgatttta ttaccatccc ggttttattt caggccagca 2838721 acatgagcga tatgggcagc agtgtaaaag aactgttcca tcctctgttt atcgccctgt 2838781 ttgtggattt ggtttttctg ctgttgttcg ccagaaaaac caaacaccca cagacaaaag 2838841 ccgctcccca cacgatcaaa cggtactatg cagcttcctg cggaatgctt ttatgcacac 2838901 tggcacttgc agaagtacag cagccgaagc ttttggcaca ttcttttgac cgggaaatgc 2838961 tagtcaaaag catcggcctg tttcagttcc atatttacga tacaatttct cagactgtta 2839021 atatcagcgc gaaagctttt gccgatgaag acagtataac tgccattaaa aactacacag 2839081 aggctgatta cagcaagcct gatcaaagca aattcggtct tgcaaagggg cgcaatgtca 2839141 tctttgtaac acttgagtcg acccaaagct ttgttctgaa tgaaaaagta aatggaaaag 2839201 aaattacccc atttatgaat gatctcataa aaaaaagcta ttcctttgat catttctatc 2839261 agcaaacaga acaaggcaaa acatcagatt cagaatttat cgtcgctaac tcactgtatc 2839321 cctcccttag cggcgccgtc tttttcacga aaagcgacca tcaatttcat acgatgtata 2839381 aatcgctgaa gcagcacgat tattattcag ccgtctttca cgctaaccat aaaacatttt 2839441 ggaacagaga tgtcatgtac gatacatttg gcattgaccg cttttttgat gttgatgatt 2839501 ttcatgtcac tcccgggaca tcgacaagct ggggcttaaa agacaaagaa tttttagagc 2839561 agtccgccaa aaagctgaaa agcctaccgc agccgttcta cagcagtttt atcacgttaa 2839621 cgaatcattt tccgtttgag attgatgaaa aggatcagct gatagatgaa ttcgattcaa 2839681 gcagtgatct gttaaaccgc tatgtgacca cggttcgcta tgaggatgaa gcattgaagc 2839741 attttatcaa aaaactgaag gacgaaggct tatacgaaaa ttcgatgatc gtatttatgg 2839801 gagatcatta cggcatttct gaagcccata acgaggcaat ggctgagttt ttagggaaag 2839861 acgaaatcac accgtatgac aacgttcagc tccagcgggt gccgtttatc atacatatcc 2839921 cgggaatcac cgatcaacag ccggaaacca tccctgatgc cgggggacag gtcgacgtca 2839981 ggccgacgct gatgcatttg ctcggcgttg agacaaaagg cgatatccaa ttcggcaatg 2840041 atttgctgtc gggcgaccgc accccattcg ccgttctgcg aaacggcagc tttattacga 2840101 acgattatgt atacacaaag aacacgtgct atagccaaaa aacaggtgaa gtgctggaag 2840161 atcaggatgc gtgcctccct tacaaggaga aagcaaacga agaactgtct ctctctgata 2840221 aaattttaaa tggtgacctg ctcaggtttt ccgaatgaaa aaatccctct atcaagaggg 2840281 attttttacg tttccaatat caccttgcca gtcagcttcg tttcatagcc gtttaaatga 2840341 gacagattcg ccttgtagtc ctcagaattc aaaatctcct tcacggcttt gagcaactgc 2840401 tcattttttt tcaaaacaac gatatcatat tgttcgtcga tgagcgggat aaaatcaaca 2840461 ctgcccatat gtgccgcgtg ctgtgccccg attcccgcgt cagcctgtcc gcttgaaact 2840521 tgtgaagcgg cagcgtaatg atcagtcacg atatcgccat atcccactac atcagccgga 2840581 ttcacaccaa gcaagccaag ctgttcatca aggagcaccc ttgcgccaga acccttttcc 2840641 ctgttgatga tccggatatc ggctcttttc aagtctttcc agccttgaat gtttttcgga 2840701 ttcccttttt gcacatacag tcctgctttg cggagaacga cattgatgag acaaaacggt 2840761 tcacctgtca aaatccgttt tacataaggc gcgttatact ggcccgtttc tgcatcgtac 2840821 aaatggaggc tgacaatgtc acacttgcct tgatacatat caatcaggct gtttaagctt 2840881 cctttgtatt tacggagcgg cgtctcctga atggcattct ccaaatgctt gctgaggata 2840941 tccatcgaaa tgtcctgtcc gctgatcatg acatttggtc tgccgtccgg ctcagcctcc 2841001 tgcacctgtt tcggcgcttc ttttgcagcg atgggctgag acattctcat attcgtttta 2841061 tattgcttta aatcttcttc atccacacgc atctgccttc cgacacggta agcaggcagc 2841121 acgccttttt taatcaagtc ataaacggtc agctttgata ccttcagcag acctgcaact 2841181 tcttctatcg tataggaaga ggtttcattc atcatcatca ctctcctatt ttattatacc 2841241 ttttcgccga atgtaaaaaa acccacataa accaaacata atcagttata attagttata 2841301 tctaatgata aggggtgcaa tcatgtttaa gaagtattct attttcatcg cagccttaac 2841361 tgcttttctg cttgtagcag gctgttcttc aaaccagtct tcaacggaca gcgagaaaaa 2841421 agtaacgtta accatctcag ctgccgccag cgcgcaggat gcacttgagg aaatccaaaa 2841481 aaattatgaa aaagatcatc aacatataac catccaagat aactatggct catccggcgc 2841541 cttgcaaaaa cagatttctc aaggagcagg agcagatctg ttcttctcag ctgctgagga 2841601 taaatttaaa aagctggtgg atgatggaga tatcgcaaaa aaagacagca ctgaattagt 2841661 cggtaatgaa attgtgctgg tcgtaccgaa aaacggagat tcacctgtga caagcttcag 2841721 caatctggct gaatcagaaa aaatcgctct tggcactccg gaatccgtac cggcaggagc 2841781 ttatgggaaa gaatcactga caaagctgtc tttatgggac aaagtgaagg ataaaattgt 2841841 gtatggaaaa gacgttcgcc aagttctttc ttatgttgaa accggcaatg tagacgcagg 2841901 tgttgtttat aaaacagatg ccctagtctc gaaaaaggtc aacattgttg acgaggcaaa 2841961 agcagataca cacagcccaa ttgtctatcc gttaggaatc gtaaaagata caaaacaccg 2842021 taaggaagcg aaggaatttt acgaatacct gcaatctgat gaagcaatga aagtatttga 2842081 gaaatatggc tttactgccg agtagcataa gcgcttcaga atttttcaca cccgttgtgc 2842141 tttcctttca ggtggcggca gttgccggaa ttgttgtcat tattctcgga acacttgctg 2842201 gagcatggat gtcacgggca tcatttttcg gaaaaacggc actcgaaaca tgttttatgc 2842261 ttccgctcgt tcttccgcct actgttgtcg gttttattct gatcgtcatt ttcggaaagc 2842321 acagcttcat cggacaagcc atcgagtgga ttttccagca gcctgtcatt ttcacctggt 2842381 gggccgctgt gatcgcctcg gctgttgtag cctttccgct tatgtatcaa tcagccaaaa 2842441 ccggatttgc tgacattgat cccgatatac aaggtgcggc aatggtagac ggcgctagca 2842501 gatggaaagt gtttatccat atctccgtcc cgcttgccta tccttcgtta ctgaccggaa 2842561 gcatccttag ccttgcgcgg gcgctcggag aatttggcgc aacactcatg tttgcaggaa 2842621 acatccccgg tgttacgcaa acactgccga cggcgatata tgtcgcattg gattccggca 2842681 acaataccct tgcttgggcg tgggtcgtct gtattgttgt catttccttt ttgatgctgt 2842741 ttttcattca acagaaaaaa acgcactaaa aaaactcccc ataacgggga gttttttgat 2842801 taaaacagaa gctcatcagg atttggaccg acacgctcat ctttatttaa tgcgtcaatt 2842861 ttgtccatgt cttcttgaga caattcgaaa tcaaaaatat cagcgttttc gatgatacgg 2842921 tgttctttaa tggattttgg aatggttaca actccatgct gcagatccca gcgcaaaatc 2842981 acttgagcca cagatttatt gtgtttttca gcaatctgtg tcagtacttc gttatccaaa 2843041 agctgtccct gcatgagcgg agaccacgct tccagctgaa tgccttgccc tttgcagtaa 2843101 tctcttaatt ctttttgcgt caagcgaggg tgaaattcaa cttggttcac catcggtttg 2843161 atttcagcat ctttcaacag ctcttctaaa tgatgaactt ggaaattgct gacgccgatc 2843221 gcgcgaattt tgccgtcttt gtacagcttt tcaagcgcgc gccatgtatc tttatattta 2843281 tctttgccag gccaatggat caaatataaa tctaagtaat caagctgcag tctttctagg 2843341 cttttttcaa aggcagcaag cgttgtttca tagccttgat cttcattcca cacttttgat 2843401 gtgatgaaga gctcttctct tgccacaccg gattctttaa tcccgatgcc aacgccttct 2843461 tcatttttgt agatcgctgc tgtatcaata ctgcgatagc catttttaat tgccgctttc 2843521 actgattcag tcgcttcatt accattttct actttaaaaa cgcccagacc gaaccaaggc 2843581 atttcaactc cgttatgtaa ctttacagta tcttttaaac ttgttggcac ttgaacctcc 2843641 accctttcac tgaaatgtaa gcgtctatat tatctcacat tcctctcagc cgataccaat 2843701 aatacgctta agaccctctt tttgcttctt ttttcacagc acaggcaaat ccaaacacta 2843761 tttttttcct attttaacaa tattgagatt acaaatacat tgagcagggt atgcgtgtag 2843821 tgtaaccaaa tgaaaacaaa ggaggaaaca acttgaaacg tattcgtatc ccaatgacac 2843881 ttgctcttgg tgccgctttg acaattgccc ctttgtcctt tgcttccgct gaagaaaatc 2843941 ctgctccgaa gatgtcgcag acaactactg ctggaacaac tgccgctgat gtaggtttaa 2844001 acgtcaacct ggatgtactt ggaattgcca accagatcgc tgatgccatc aaatccgcac 2844061 agaataggga tggctttgtg aaaaacctca tggagtcttc cttctacgcg tccggccaaa 2844121 aatataacgt catggtcttt aatttaagcc aggaatatga agatcatttg aacggtgtgc 2844181 aattttacgg ctcagccgtt tacgacggca ttacgtatgg catttgggta tttgaagatg 2844241 gaacctttac aaacaaaggc gatggcggct ggatcaactg ggccttcaga ggctggttcg 2844301 accgggatgg cagcactgtc gcatttcatc gcccttaata taaaaaaagc tggcgctcta 2844361 acgccagctt tttttctgca tttattcgcc gccttcaagc atggcggctt cgacatcatt 2844421 aatgtattgg cgaagctcat gggagatgtc ccgggaaatt tccctctctt cgaagagcgt 2844481 ttgaatttca tttctgatcg cctgcacagc cttcagcttc acttccagct tctgattttc 2844541 aaaatgggca cttgatttta actcatgatg gctgtgctcc agcctgaaaa ttaactgctt 2844601 atagaatgta atgacagata aaaacacttc tttatgctca tccgtcttat gtttttccag 2844661 atattctatc gctgcttttg ccgttttcac tcttgttgcc cgtatcaatc ccgcttcatt 2844721 taaaatcgac atctccggct ttttatgttc accgaagaaa atccaataca tcagcctctt 2844781 gagccttgtt tttgataacc cgactttaaa cgggttggca tacaaaattt ccaactcgtt 2844841 aaatcgttct tgcagcacat ttgctgtttc ttccgggatg tctccccgct ccagcatttt 2844901 catcagcgcc tcttgctcag ccttaacccc ctgcgcacgg acttttcgct cgtgcttctt 2844961 aatgcgatta gatgatgtat actgctgaaa acgaagattt ttcattttct cattgtattc 2845021 agctatcacc gcaagagagg ccgttttgtt tgtctcattc atgtcctctt taatcgtttg 2845081 aagggctgtt ttgatcaact tgcgtctcgc cgtcagcagc ttcttatttc gttcctcgtc 2845141 ctcttcttct ttttcagtca gaattggcag cacaacggtg gcaatgacaa gcgtgcataa 2845201 aatgacgccg gctgctaaaa agagaatcag atttctttcc ggaaacggcg taccgtcctc 2845261 caggaaatac ggaatggaaa aagaacctgc aagcgttact gctccacgca caccggaaat 2845321 cgaaattaac agcgtcgaac gaagacccgg tttatagatg ttctgatctt tattaaagaa 2845381 ccatttgccg ttccagaaga acagcaccca caggaatcta aggagcatta atgtaaatgt 2845441 gatgactagg atatagccga tcaccttcat gttgctgatg gcagtgtcgt taaagataac 2845501 agaaataaca tcagggattt gcgtgccgag aataacgaag accaggccgt tcaaaataaa 2845561 taaaataatg ttccacgtac ttgaggagac gatttgcagc ttgatcatcg ttgattccag 2845621 acgatcctgt tcaaccgcat gggtaatacc gccagctaca acagctaaaa tgcccgaaac 2845681 gccgatttct tcagctgcca aataaatcac aaacggcgtc agaatttgaa tcagcatatg 2845741 catcgtgaca tcctgcatgc caaggcggcg cagaaatagg cgaaaacgaa taatcaaaaa 2845801 tgaaatgaca accccgcaca gcaagcctcc gagagaaata aagacaaagc tgacagccgc 2845861 ttgtgctaat gaaaatgcac cagtcactgc cgctgcaatc gcaaacttaa aggccaccag 2845921 acctgatgca tcattcatca gcccctcacc ttccagcagg cgaagaatcc cttttggcat 2845981 tttcactctt cctgataatg cgctgacagc gacgacatca gtcggtgaaa gaatggccgc 2846041 aagtccaaag gccgctgcca gcggaatagc aggaatcatc cagtgaatcg tgtagccgcc 2846101 tacaatcaca gtcgcaaata caaggccgag tgcaagcaat aaaatcggag cccttaaatt 2846161 ccaaagctct gcccgcggtg tcctctttcc atcattaaat agcagaggcg cgataaaaag 2846221 aacaaaaaac aattcggtgt ttaattcaaa atgaagtccc tgtggaaatg aggcggcaag 2846281 aatcccaaga gccacttgaa tcagcggcac cggaataaac ggaataaacc ggttcacgat 2846341 attagaaatc gcaataatcg ttaataatac gagcacaact aaaaatatgt ccaaatgcat 2846401 gacctccttc gtctgttgtg tgtcggcatg atgagccaaa aaatctgttt gtctaaaagc 2846461 ccttgagcta gggtggcctt gcatccgcta tgtggtttcg caggagttct ctccacactt 2846521 gtcttctttt atagtaccct ttttagggta ttttttctca tgatatgctc acagtgaact 2846581 tttttgcaga agagcaaatt atagaaaaaa gagacaggaa gctactccct gtctctcgtc 2846641 tttctttctc aatcatgaaa attcgtaccg tcagttgttg ctttaataat gcccgcgcga 2846701 atgacaaagt caccgaaatg ctcgccttcc tcgcgttctt tcgcatagcg ggaaagaagg 2846761 atgcgcagct cgcttaaaat gtctgcttca ccgatgtttt cacggtacat tttgcttaaa 2846821 cggcttccgt caaacgcagc gccaagatac atattatatt tgcccggcgc ctttccgata 2846881 aatccgatct caccgagtgc atgacgtgca cagccgttcg ggcatcctgt catgcgaatg 2846941 gtgatttcct gatcacgaag gccgttttcg tcaataatct cttcaatctt atctaacagg 2847001 gtcggcaaat aacgttctgc ttcagccatt gccaatccgc aggtcggaag agcgacgcac 2847061 gccatcgagc tgcggcgaag cgctgaatag tgcttgccgt cagttagtcc gtactgttca 2847121 attaaagcac tgatttcttc ttttttatcg cttgaaacgt tcgcaatcat taagttctga 2847181 ttggctgtca gccggaactc acctgtatga actttggcga tttcccgcaa gccagtcatc 2847241 agcttataat catcgtaatc cgttatacgg ccgccttcga caaacagcgt gaaatgccat 2847301 ttatcctcga tgccttccac ccagccatag cggtcgccgt tatgatcgaa atgatacggc 2847361 ttcgcttctt ccaggctcca gccgagacgg ttttccaatt cttcttttac gttttctaaa 2847421 ccgaggcggt caactgtgta tttgaaccgc gcatttttac ggacagaacg gttgccgtaa 2847481 tcacgctgaa tcgtaatcgt tttttcagca acgtcataca tttgctcagg ccggcagaaa 2847541 ccgatcacct tggctaattg cggatatgtc gcagtatcgc catgcgtcat tcccataccg 2847601 ccgccgattg ccacgttaaa accgatcagc ttgccatcct cgacaatcgc aatgaatccg 2847661 agatcttgtg aaaagacgtc aatatcatta gacggcggaa cggcaatacc gattttaaac 2847721 ttccgcggca gatagagcgg tccgtacatt ggctcgactt cttcctccgg cgtgccggca 2847781 actctttcct catcaagcca aatttcatga tatgctctcg tccgcggcag cagatcatca 2847841 cttaattttt tagaccactc gtatacctct gagtggattt cagattgata agggtttgat 2847901 gcacacatga cgttacggtt tacgtctccg caggctgcga tcgtatccaa aagtgctgag 2847961 tggatcgtct gaatggtttt cttcatgttc catttcagaa ttccgtgcat ttggaatgtt 2848021 tcacgtgtcg tcaattttaa tgtgccgttc ccgtatttct gggacaggtc atccatgaca 2848081 agccattgtt caggcgtcga gacgccccct ggcatacgca cgcgcagcat gaactgatat 2848141 gcgggctcaa gcttctgctt ttggcgttca tttcggaggt cgcggtcatc ctgcaaataa 2848201 ctgccgtggt gtttcatcag gcggttatca tcatccggaa ttcccgcact gattcgatcg 2848261 agcatcactt ctttcagcgt gccgcgcaaa taatcacttt cttttttaat gcgttcaaca 2848321 tcacttggag agccgtccgg tgcttttaga attttggtca ccatgttgaa aaactccttt 2848381 caagtcaaat caatatacat cacgctgata gcgtttttgc tgctgcatat cggcaagata 2848441 agcctccgcc tcttcgcggc tcatattgcc ttctttttcg ataatttcaa gcaatgtgtt 2848501 atggacgtca tgcgccatgt gcttttcatc tccgcaaatg taaacagccg ctccttcttg 2848561 aagccattca aacaattctg cgctatgttc aagcatgcgg tgctgcacat atactttttc 2848621 ttccgtatca cgtgagaacg ccacatccat ttttgtcagc acaccgtctt tgagccaatt 2848681 ctgccactct gtctggtaaa ggaaatccgt gacaaagtgc tgatcgccaa agaacatcca 2848741 tgcctttcct tccgctcccg tctcctcacg ctcctgcata aacgaacgga aaggtgcgac 2848801 gcctgtccca gggcccacca tgataatcgg tgtttcaggg tctttcggaa gcttaaagtt 2848861 ttgattgtgc tgtacataaa ccggcagtgt gtctcccggc tgcagtcgtt ccgcgcacaa 2848921 aatcgagcag acgccttttc gttcacggcc gtgcgcatcg tagcggactg cgccgattgt 2848981 taagtgcact tcatccggat ttgcggataa actgcttgca atcgaataaa ggcgggcagg 2849041 catttttcgc aaaatcgaga caaactcctg cgcagataca ctaaatgggc catagtcacg 2849101 gacgagatca agcaaatcgc gcccttcaat ataggctttt acattctcct catttcccgg 2849161 ggctaaaagc tctctaagct catcgttccc tgtcagctgg gctgcctgtt caagaagcgg 2849221 ttttgtgaga acggtaatct catagtgaga aatcagcgct tctttcagcg gtcggacatc 2849281 accttgctta ttaagcgtca caatttcttc cgggtcccaa ttcatttcct taaggagcag 2849341 ctcgacaagt tccggatcgt tttccggata gacgccgagg ctgtcaccag gctcgtaagt 2849401 caggccagat ccttcaagag acagctccac atggcgtgtt tctttatttg atcctctgcc 2849461 gtttaaattt aaattttcta acacttcagc ccgaaacggg tttgttctgg aatacgaaga 2849521 ctcaccggtt tgtgacgcag ccgccggcgc aggcgcggcg cttccgcccc cagcttcatt 2849581 taatcctttc aatacaccct caagccattc ggctgccggt tcatcatagt caagatcgca 2849641 atcaacgcgc ggagaaatcc gttttccgcc gagttcttct aagcgttgat caaattcttt 2849701 ccctgtctgg cagaaaaatt cgtacgaact gtcaccaagc gccaaaacgg aaaagcgcag 2849761 gtcttcaagc ttaggcgccc gtcttccgtg cagaaattca tgaaacgaca gcgcgttatc 2849821 aggcggctcg ccttctccat gcgtactgac gacgattaaa agattggtta ccttcttcag 2849881 ctgattcggc ttaaaatcgc tcatggatga gacggtcact tgaaaaccgc tctgttcaag 2849941 ctgcttgccg gcattttctg caagcccctg tgcgtttccc gtctgtgaac cataaagaac 2850001 ggtcacttct tttgaaacgg ccggtgccgg tgcttccgct gacacagctg ccgccggcgt 2850061 acccgcagct tcttgggcgg aaacagattg agcggataaa tatccgctca gccagatttt 2850121 ctgggattcg gtcaaggtcg gcagaaggcg gttaaggagc tctgcctgct cctgattaaa 2850181 cggactgttc attacctgaa gttgcaacgt atccacctca caaagttata aactgatcga 2850241 aaattgcatc taattgaact ttaccggaat actaggctta agtaaaatat atttacatga 2850301 tgataactat taagaatcct aatgataaaa cggctatgct tcatgtaaat agaaaaaaga 2850361 gaaggactcc cttctcttca ttcagcaatc tgatataagt gaggcggcac agcggttaca 2850421 aacggactgg cttcacctgt ataaaatacc gccagcatgt gcatcgcacg ggtgcacgca 2850481 gtatataaaa gcctgcggtc gtgctctgta tgatagtgtt cttcagatgc atcatagaca 2850541 agcactgcgt caaattcaat tcccttcgct aaatacaccg gaatcacgca aacacccttt 2850601 tgaaatggtt gattttcttt atgaatcagg cgaacatctg tatattcact catgtgggcg 2850661 tgcgcctgta tgcattgatg cgcagtcttg cagatgacgg ctattgtttc gtgccctttt 2850721 ttcttgagcc ggccaatttc ttgcgcgagc ttttggcaaa ggctctcatg tccttcagtt 2850781 ttgacaacga gcggcatttc cccgcttcta ttaaacggct caatatccgc tccatcttga 2850841 agcatcgctt tggtaaactc gacaatctgc cttgttgatc tgtatgttct ctttaaacga 2850901 acatactcag caggctcatc ctcaaagcac gcatccatac gctgatcccc gtttatggta 2850961 tgcgcgtaga tggactgatt gatatcaccg agcactgtca tgctggcagc cggaaaaatg 2851021 cttctcatgt aagccatctg aaacggtgaa tagtcctggg cttcgtcaat aaatagatgt 2851081 ttgattttcg tatttttctt tctgccctca atcagatcct gcatataaag aaacggtgcc 2851141 gcgtcctcat agagcaattt attatccgta aatgccgaac gggtcagctc acctatcgca 2851201 tccatcttct catgttgaaa ttttcctccc cagccagaaa acaattgcaa ataaagttgt 2851261 gtaacatcaa gaaatgcaag gagcctgact gcctgtttga gcggtttgaa agcttttttc 2851321 acaatgatgg cggcaagcag ctgctgctct ctttgataat cgttaaacgt actctcgctg 2851381 aaccgtttcc tttcctgcag ttttttgtac acgtccaagt agtcctcttt gtcaagcagc 2851441 tcagcttcat gaacaaccca atcctttcgc cgttcctttt tctcaagctt gttaagctca 2851501 ctcagcagcc acttcgcggt ttgctccatc cgattcggaa tggagtgatt ttgatccaat 2851561 gagtaaaaat aggattgaat ttgctccttt gtgatcagct tttgtccgcg gaatataata 2851621 tttttaaaaa tcatcccttc agaggaaagc cgtgtgacgt attcattaat gaattgctga 2851681 aaggataaac ccgccttcca tgtgattcct gcaagccttg ttggaaaatc gcctcccttt 2851741 gtttcggtca ggcaatattc gagctgatca aaggggcttt cacatttgaa cttgcggcca 2851801 agacgatgct cgatatattc ctgaaacgtc gcctgctcca tattctcttc tcctaactcc 2851861 ggcaaaacag aggagacata gctgttaaat aagaagttgg gtgaaaacaa aacgatttgt 2851921 ccggcatcaa tgacaccgcg gtgcctgtat aacaaataag cgacacgctg aagcgcagcc 2851981 gatgttttcc cgctgccagc cgctccctgc acgatcagga tcttgctttt ttcattacgg 2852041 ataatctgat tttgttcttt ctgaatcgta gacacgatgt ttttcatttg ggtatcagag 2852101 tgatggctta atacctcttg cagcatttca tcgccaatcg tcatatcggt attaaacatc 2852161 gccttgagag tgccgttttt gatcataaac tggcgtttca gcaccatttc cccttctatc 2852221 gtttcaccgg gcacctcgta ctccgctttt cctggggaat aattgtagta caaacttgat 2852281 atcggcgccc tccagtcata gatcagaaag tgttcctcct tctcatccaa acaggaagct 2852341 aaaccgatat aaattcgctc tgcctgctcc tcgccgtttt caataaaatc aatccggccg 2852401 aaataaggcg attttttcaa ttgatgaatt cgtttgagct gctgatccat gcgccgatga 2852461 ttgtgttccc gatcagacag cagctctgcc tgctgcttaa tgctagccat cgtttcaatc 2852521 gcttcatggg catcatcaaa attaacctta acatcctccc aaaagctttt tcttaatccg 2852581 atgatatcat gcttcaaccc gcccgcagac gtttccagaa accgctcttt tttttcgagc 2852641 tccttcagca cctcatctat tctcgactgc tcttccttcc attccttatc ctgctgattc 2852701 atgaacggca cctccagaaa atagttgaca aacatagatg aaatactgta aaatataatt 2852761 ggatacatat attaaatata tgatgcaaac tggcaaatac aatttataat agcacattca 2852821 cccaatacca atcaaggttt gggttattta tattatgcag aaaaaaaccg atttcacttc 2852881 gaaatcggtt tttttgctat taattatcta agcgaaaaga acggtttggc agcttccaat 2852941 taaacatata ggaacaaacc cggcaaacaa cgagcacgaa aaacagaacg tataagccga 2853001 acgagttccc cagccagccc aagccgacga ttaaaccgcc gagcgccgcc cataccgcat 2853061 agatttccgc tttcagcaca agcggtttgc gcccggcaag aaggtcgcgg atgatcccgc 2853121 ccccgcttcc cgtcagcacc gcagccacga tcacggcact aagcggatgg cccattttga 2853181 cggcatacag tgcgccttgg atagcaaagg cagcgaggcc gatcgcatct gataaattgc 2853241 cccacttatt ccaatgcttc agcagcagct tcggaaacag aaacacaatt gtaatagata 2853301 aaagcgcgat ttgaaagtac gctccctgct cccatagcgc tgacaccgga acaccgatca 2853361 gcaaattgcg gatcgctcct cctccaaaag ctgtgacaat ccctaatata taaactccta 2853421 aaatatcata ttcctcttcc atcgcaacaa ttgcgccgct gactgcaaac gcaatgatgc 2853481 caatcacact aagcagctcc caagccattc tgatgactcc cttttatgtt tgttaaattt 2853541 tctgacgacc tctagatttt ataatcgctc cagcgtaaaa tcaataacat tttcatgaga 2853601 aaaaaagata aatttagagg gaatacggct attgctgatg gacatgagtt tgcgaaatta 2853661 aaaaagcgcc cggcatacgc gggcgctttt tttgttattc agatttttcg cctttcagca 2853721 ggcacataaa aatgataatc aggataaaag caatcagggc caggaatgga atcgtaataa 2853781 aaccaaacca gttaatatat tggcccgagc acggcacgcc gctgacacat ggcttaatgc 2853841 cgctaaagcc gggcactttt tgctctaagt aatgcatgat cgaaatgaat gccccaataa 2853901 tcgccatcgg gagcacatat tttttcactc gtgtgtcccc ttgaaaggtg gcgatgccta 2853961 aaatcaggac gagcggatac atgaggatac gctggtacca gcacagttca catggaataa 2854021 actttctgat ttcactgaaa tacaggctgc ccagcatagc gataagagcc acaacccagg 2854081 aagcatataa aaatacgatt ctatttttca tattgttact tccctttcag ctctttttct 2854141 attgtctctt tgatttcatc ataatccgca aaatttttga tcactttatc attgacgtaa 2854201 atcgtcggtg ttgcctgtat gttcattttt tgattaaggt cagaatcctt ttccacttga 2854261 gaagcgaatg tttccttatc aagattttcc ttgagcgtct caggttttat ctttgtggtg 2854321 ctttttgcaa gatcaccaag gaggcctggg gttacccatt cctgttccgt atccggctgt 2854381 ttttcgaaca gcttttcatg gaaatcccag aaagagtcag ggtcttcctt ccatacttct 2854441 tcagatgcaa gagccgctaa ccttgaacct tttccatgga acatgacgtt cacgaaagaa 2854501 aatttcacat cgcccttatc aataaagtct ttttgtattt ttggaaagat gtcactgtta 2854561 aacaccttgc aagacggaca tttgtaatct ccgaattcta ctacagttac cggtgcatcg 2854621 tccttgccaa gcacaggctg ccctttgata gacggctgtc cggacaccgc atcattgcct 2854681 tgttccgttt tgttattaat gatgacaatg gctgctagca atacaacaac cacaaccgta 2854741 aggatgaccg cgaatttcgc agaagactgc tgtttctttt tcactccgac acctcatcgt 2854801 tttaaaatta aaaaagaagc ggatcgcaat tgacccactt ctttatttta acaagacaag 2854861 cgctgataag aaaaccccga aaaaatgaat tctctccgac aatttatttg tttttgagac 2854921 gcatgacgcg catggcgttc gccacagcaa gcagtgtaac gccgacatct gagaaaaccg 2854981 cttcccacat ggtcgcaatt ccaaatgcac caagaatgag aaagatcgct ttcacaccta 2855041 aagcaaagcc gatgttttgc cacacgattc gccgtgtccg tttcgcaatc cgaatcgctt 2855101 ctgctatttt tgacggctga tctgtcatca gcacgatgtc tgcggcttct accgcggcgt 2855161 ctgagccaag gcctcccatc gcaaccccta tatctgcgcg tgcaagcacc ggcgtatcat 2855221 tgatgccgtc accgacaaaa atgagttttt cactaggcaa aagcttagct tctaatgctt 2855281 cgacctgcgc gactttatct tgcggcagca gctctgcata tacctcacca atcccaagct 2855341 gttttccgac ggcttctccc gtttgtttcg aatcacccgt cagcatagct gtctgtttga 2855401 tcccaagcga cttcagatca gcaaccgcct gtgctgcgtc ttcctttatc tcatccgcta 2855461 tgatgattgc tccggcatag cgttgatcta cagcaacgtg tacgattgtt ccagcatttt 2855521 catccgggac atcctcaatt tgttctcttt ccatgagctt tttattccca gcaaggatct 2855581 cagttccatt tacctttgca aaaatgccgt gaccggagat ttcttcgtat gactcaatct 2855641 catcggagga aagcattttc ccgtaagctt tacgcacaga ttcagcaatc ggatgctgtg 2855701 aatgaagctc agcgtatgcc gccgcttcaa gtaatctatc ctttgtaaaa ccttccgcgg 2855761 gtttgatttc tgtcacttca aagctgcctt ttgttagtgt tcccgtttta tcaaacaccg 2855821 cgtatttgac ttgattcaaa gcttctaaat aattgcttcc ctttacaagc actccggcct 2855881 ttgaggccgc tccgattcca ccgaagaaac cgagcggaat agagacaaca agcgcacaag 2855941 gacaagaaat cactaaaaag ataagcgcgc ggtacaccca atcggaaagc gcggcgccag 2856001 aaagaacaag cggcggaaca aaggccagca ataccgcaat gatcaccaca gcaggtgtat 2856061 aatacttggc aaacttcgtg ataaagtttt ctgtccgggc tttacggctg ctcgcattct 2856121 gaaccaagtc taatattttt gatactgctg attcctgata gccctttgtg acttcaatat 2856181 gcagaacgcc gttttgattg ataaagcctg acattacatc ttgtccttcc gcagcttttc 2856241 tcggaacgga ctcacctgtt aaagcagatg tatcaaccat cgctgaccct tgcacgacct 2856301 taccgtccag gggtatgctt tctcccggat taaccacaat gatgtctcct gtctgaacgt 2856361 cctccgacga aacctgttcg atgccgttct ttgttttgag attggcgtaa tcaggccgta 2856421 tgtccattaa cgcactaatt gattttctgg aacggctgac cgcggctcct tgaaaaagct 2856481 caccgatttg ataaaacagc ataacggcga ccccctcagg gtattgctga atcagaaaag 2856541 cgccgattgt ggcaagagcc attaagaaat gctcatcaaa cacctgaccg cggatgatgt 2856601 ttttgactgc gcggattata atgtcaccgc cgataatcaa ataagcaccg aggaaaagga 2856661 aaaattcaat ggttcccgac tgaaccaaat atgccgctgc gccgagaatg acagccgccg 2856721 ccattctgat cagcatattg accattcgat tacgatagcc atcatcagct gatttcttta 2856781 tatgcttttg gcgaaccgtt acatgcggat caattgattt cacttttttc tctactttat 2856841 tcgtgaccca ttgctcttct ttcccatcgg ctgagacagt taaggtgctt gccgcaaaat 2856901 ttaccgcgca tccgttaatg ccttttatgc ctttgactcc attttcgatt tttcgggcac 2856961 aattgctgca atccaaaccg tccagaacat attcctgttt cactagtctc accttacctt 2857021 ccgatttagg gttccctctt caaagcgtat caatgagtat tgtatttatt ttatatatat 2857081 gagcatatac tcatatataa gttacaccta ttatatgttg ttttccaaga aagtgtcaat 2857141 gaaaaacaaa aaccggcata tagccggttt ttcattttac tttttgcaga cgaagagcat 2857201 tcagaacaac ggaaacggag ctgaatgcca ttgctgctcc tgctatccac ggtgctaaaa 2857261 atccaagtgc tgcgattggg atgccgaggc tgttatagcc aagcgcccag aataagtttt 2857321 gtttaatgtt tttcattgtc aatctgctca tgcggattgc gtcggcaatg ctgttcagat 2857381 cgccgcgaat aagtgtaatg tctgctgttt ccatggcaat gtccgtgcca gttccaatcg 2857441 ccatgccgat gtcagctgtg gcaagcgccg gcgcatcgtt aattccgtcg cctaccattg 2857501 ctgtctggcg gccttctttt tgcaagcggg cgatttccgc cgccttttgt tcaggaagaa 2857561 cttccgcaat gatattcgca attcccgctt ccttcgcgat ggcttctgcg gttctgcgat 2857621 tgtctcctgt catcatgatg acatcaagac ccaactcttt cagacgggca acagccttcc 2857681 gcgacgtatc cttaatcgta tctgcaactg ctactagccc cgctgcttct ccatcaatgg 2857741 atacaagcat aactgttttc ccttcggcct ctagctcttc catttgggcg agaagagccc 2857801 catgctcaac ctgttcgctc tccattaatt ttcttgtgcc gacgagaatg ctttttcctc 2857861 cggcttcagc caaaatgcct gcgccgactt ttgcttcaaa gcgggtaagt ttcggtatct 2857921 caagcccttt atctttcacg ccagcaataa tcgcttcgcc aagcggatgc tctgatcccg 2857981 tttccgctgc cgctgcaaat tgaagcaaat ctttttcttc aaaacggccg aatggaatgg 2858041 catccgtcag acgcggcttc ccgtttgtca cggttccggt tttatcaaga acaattgtat 2858101 cgagacgatg tgttttttct aaatgctcgc cgcctttaaa taaaatcccg aattcagcag 2858161 cgcgtccaga tccagccatt atgctcgtcg gagtggcaag accgagggcg caaggacagg 2858221 caatgacaag aaccgcaatg aacttgctga tcgcttcggc aaaatcgcca ggagccgccc 2858281 aaagatacca aatgagaaaa gtgagaaccg caatccccaa tacaatgggt acaaaaatgc 2858341 ctgaaatctg gtcagcgaga cgctggatcg gcgcttttga cccttgtgct tcctcaacaa 2858401 ttttgatgat atgagaaagc gcagtatcct ttccgacgtt gacagcttta attttcagaa 2858461 agccgtttgc gttaacggtt gaacctgtca cgctgtcacc aggatttttg tcaacaggaa 2858521 gactttctcc tgtaatcatc gattcgtcaa ccgctgaacg gccttcaacc acttctccgt 2858581 cgacaggaat tcgttcgcca ggtttgacgt aaacaatgtc attaacaagc acttcgtcga 2858641 tcgggatgat ttgctcctgt ccgtctctta caacagtagc tgttttcgct tgaagcttca 2858701 tcagcttttt aatcgcatcc gaggaacggc cttttgcttt tgtttcaaac aacttgccta 2858761 ataaaatcag cgtcagcaaa atcgcgcttg tttcataata aaggccgtct gtatgcccgt 2858821 gagagccaat gctttgaaaa gttagataaa gactataagc gtaagcagcc gtcgtaccga 2858881 gggcgaccaa tacatccata ttggcgcttt tatttctaag cgccttatac gcacccacat 2858941 aaaacggcca gccgatcaga aactggactg gtgtcgccag cgcaaactgc atccacggat 2859001 tgagaaatat atccggtacc caaatgaatg atgtaaatgt aaaatggctc accatcgccc 2859061 aaagcaatgg aaatgacagg acagctgaaa aaatcagtct cgccgtttgc ttccgttctt 2859121 ctttcttttt agcagcagcc tcactgtcct gttcaccctt caactttagc ttatatccaa 2859181 gcttatctac cgcttctttc aaatcgctga cagacgcttc ttttggattg tattcgaccg 2859241 taactgtttc taaagcgaag tttactggtg catttgcgac gccttctatt ttgttaagcc 2859301 gtttttcaat ccgattggcg caagccgcac aggtcatgcc ctcaatatcg aattcagctt 2859361 tttctgtaac gacgtgatag cccagcttct ctattttttc ctgaatcgct gcagtccctg 2859421 tttcagcagg atcgtagatt acatttgatg tttccgttgc cagattaaca tttgcatccg 2859481 tgacaccggg catccgcttc aggccttttt caattctggc agcacatgcc gcacaggtca 2859541 taccagagac ctgcatcgcg atttcctttt gttcactcaa catactcact cctttatata 2859601 cacctggggg gtatataaaa atgaaagaaa tatcgcgcct ccctaaaggc gcgatacctt 2859661 gaatcacttg gctacgtcat agccctgatc ttctatcgca tccgcaatat ctttgactga 2859721 tactttgtca gcatcaaacg aaacatcgac tttacccgct tccagattga catgaacggc 2859781 actgacgccg tccagttctc ctacgcttgt ttctactgct ttgacgcagt gctgacaaga 2859841 cattccttca acttgcaatg ttttttgttc catatcaatt cctcctgttt attctttcta 2859901 ttttcatcct accatacccc cgtagggtat tacaataaaa aacgctttat gattttgtga 2859961 actttttaaa tacgtccaaa agctcagaaa tggcctgttc cccgtctccg cttttgatgg 2860021 catctgctac acaatgatgg gcatgatcct caagcaaatg aagcgccaca tttttcattg 2860081 ccgcctgaac agctgaaatt tgcacaagaa tatctacaca atatctgtcg ttttccacca 2860141 tgttttgaat gcctctgacc tggccctcaa tccgcttaag ccggtttgta atctgatcct 2860201 tttctttcga gcttttatgg tttaatgttt tatgttcgtt atgcttttcc atgcgtacac 2860261 ctctgtttaa tgatattaat tcccattata ctgattgtcc aaacggttgt ctaagcatgc 2860321 cgacgcaaaa aatgaatcag ttaggtttta ccatttgatc aggagggtat atacttctgt 2860381 tgataacgct tttaaagggg agaagaaaag tggatacgat caaggttgga atattaggat 2860441 acggattgtc cggttctgtt tttcacgggc cgctgctgga tgttctggat gaatatcaaa 2860501 tcagcaaaat catgacatca cggacagaag aagtgaaacg ggattttcca gatgctgagg 2860561 ttgtacatga gcttgaagaa atcacaaatg accctgccat tgagcttgtc attgtcacca 2860621 ccccgagcgg ccttcattac gagcatacta tggcatgcat acaggccgga aaacatgttg 2860681 tgatggaaaa accaatgaca gcaacggccg aagaggggga aacattaaaa agggctgccg 2860741 atgaaaaagg cgtattatta agcgtatatc ataaccgacg ctgggataac gattttttaa 2860801 cgattaaaaa gctgatctct gagggatccc ttgaagatat caatacatat caagtttcct 2860861 ataaccgcta cagacctgaa gttcaagcgc ggtggcggga aaaagaaggc actgccactg 2860921 gtacgctgta tgatctcggc tcccacatca tagaccaaac cctgcatttg tttgggatgc 2860981 ctaaagccgt gactgcaaac gtgatggccc agcgggaaaa tgccgaaacg gttgactatt 2861041 ttcatttaac cctggattat ggcaagcttc aagccattct atacggagga tcaatcgttc 2861101 cggcaaacgg acctcgttat caaatccatg gaaaagattc tagctttatc aaatatggaa 2861161 ttgacggaca ggaagacgca ctcagagcgg gaagaaaacc agaggatgac agctggggtg 2861221 cggatgttcc ggagttttac ggaaagctta caaccattcg tggctccgac aaaaaaacag 2861281 aaacgattcc atcagtaaat ggctcctacc ttacttatta ccgtaaaata gcggaaagca 2861341 tacgagaagg tgctgcgctg ccagtcactg ctgaggaagg tattaatgtc atccgcatca 2861401 ttgaagccgc gatggaaagc agtaaagaga aacgaaccat tatgctggag cactaaaaca 2861461 aaagcctccc caaataaggg gaggcttttt cattagaatg tttttcctgc ttctttcgca 2861521 cgcgcaatcg cgtcttcttt gatttgctgt gctttatcag gctccgcatt atgtccctct 2861581 acgaaaatgc catcgaatga tggtacgccg aagaagttca tcatgatgcc gatgtagcgg 2861641 tgccccattt ccatctcagc cgcagggcct tctgaatagt agccgccgcg cgcttggata 2861701 tgaattgctt ttttatcagt taacaagccg acaggacctt gttctgtgta tttgaatgat 2861761 tttcctgcaa cagcaacaga atcgagatac gctttcatca ctggcgggaa tgagaagttc 2861821 cataaaggag taacaaatac gtacttatca gctgatgcaa attgatcgct aagctctccc 2861881 aaacggccta ctttcgcttt ttcgctttca gaaagctctt caaagcctgt acctgactga 2861941 agctttcccc atccgctaaa tacatctgcg tcaatgtgcg gaatgttttc tttgtacaaa 2862001 tcgatatgta caacttcatc atttggattc gcttctttgt aagattcgat aaatgcttta 2862061 cctgttgcca tactgtacga agttgcttcg tcatgtggat gagcagtgat atataatact 2862121 tttgccattt ttaccagccc tttcgttttt aaaaatcaca catcaattat tatcatacag 2862181 atgcataatg attattctgt ctctcttaga ctttattata gagacaaaga aatttacttt 2862241 caagtaaaac atctcgaatt aaagattatt taactttccc aaacagctta cttttcaaaa 2862301 gctgttctca agccggaata cagcgcggac aattctttac tgatccgagg ataatgaggg 2862361 acatgcggca cttgaatatc cgcaggcatc cttttcatga taaaggattg ctcagcctgt 2862421 tcaaaaaacg cccgcagctg gttgatctct tcatcagaaa acggagcaga cggacggcgg 2862481 tgagcttgcg ccgagagcaa atagtaccct aagtgctgag caccggaaat ggcaggccag 2862541 agcgcatccg cattcgcgtg aggaaactcg ccaagcgcct tgtcatacgc atcccgaagc 2862601 ctgacaagac tcacccttaa cttgtgttcg tcggcaattt gcccggttaa cagtttctcc 2862661 ataaactgcc cttccagccg gatgacattc cgcacaagtt ctggcagccg cttggttgaa 2862721 aaccgccgcc acaaaagcat tgttcccaac agcccgatca cgctgccgac agctacatca 2862781 gtcagcctcg ctatcataaa ataaccggcg cccgccccgc catgcatact ttctgtgata 2862841 acaagcgcat ttgcggttaa aaagggaaca gccagcgcat aattgcggac gatcagcatc 2862901 tcaagaagac attgcagcgc tgcaatacaa aacgcaatat aaacaccgcc cggcttaaaa 2862961 aacaggattg cgcctgccag tataacaccg atcaccgttc cggccgaacg ctgaatagcc 2863021 ctgtgaagcg taaaaacaac agtagtgcca agcatgaccg ctgctgccga aagcggaatc 2863081 caataggagc gtgcaaagcc gaatgcgagg gcaaacatat cggcggcaaa cagaacaatt 2863141 ccgtacttta acgctctaat caaaactgga gacttccagt caaaggcatt tctcaaaaag 2863201 taaaaagagg atggcaggcg gcttggttcc ccgtcaagct gcttatcaaa acgtcctgaa 2863261 gcgatataca aaacctcatt gatttcttca aacagcttcc gcctaggctc agattcattt 2863321 tcattaatct gaaacgtatt gaaaacccgt gcattcgcaa gcatatctcc ggtttggcga 2863381 agtgcctttt caatctgcgc ggtctctctg tccggcgttt cagctgaaaa atgaataatg 2863441 gcaataaata tgtcgtcagc tttctcaagg aggcgaaaaa atcgttcatc atgccgcgat 2863501 tttttccgtc tgttcccttt cccaagaacc gtttggcggg ctgttctaag catgagcacc 2863561 gtctgatgct gtgcgttatg aaaacctggc gttccgacgg ctgaaagaca tgcagccagc 2863621 tgatgatatg ttttttgcag caccgctccc tccggtccat gtttgttcca taaccagccg 2863681 attaaagcga tacccatggc gaaaatgccg ccgagaaacg tcagtcccgc tctgaacagc 2863741 gcttgtgaag gatcggccgg cagcccggaa ctgactaaaa aggcaaggac aaaaaacatc 2863801 ggcgcagggc cttgaatgcc gagcgcgcta aaaataaaca tcgccgctgc accgatcagc 2863861 cccaaaacag ccgccatcat ccaaagcatc ccggacaaaa gcgtccctaa accaaatgag 2863921 agggcgatcc caatagaaac caagagcagc ttcaaggcgc gctttttgta cgattcaccg 2863981 cccgcatata aataaacaaa gcctccgata cttgcaatta atccgtaatc cgtgtgacct 2864041 gccaatgcac cgaccagcac aggaaaccct gaagcgaaac ctgatccgat agcctttttc 2864101 caaggaaatg gatttgcatg aatgcgaaag gcatccttca cgataggcat gattctttga 2864161 ttgttcgcag cagttttgtt catttgacaa aatccttttc aatgaatgtg tagaactttt 2864221 ccagtttctt cgctttagta tgcccaaaaa cgcggttagc ttctcaattg gtgcgcacga 2864281 taaaaaaaca gagacttata ccgtctctgc ttcattacat cagtttatta taaaagcggc 2864341 acctgtcagg actgttttgt ccttctgcct tccttcaaga gcaggtgaat aaaaaataaa 2864401 ggataaatca atagataccc attaaacagc caccacacaa gatcaaagtc actgctgaat 2864461 gtccagaatg atagcgcctg cagacctgaa caacaggtca gcacaagaga aatcagcgcc 2864521 atcagcttcc agtcagcacg attcacccgc tgtaggtaca agctgtacaa ccctgtgaca 2864581 gaaatcagga tatccagcgg aaaaaaagac cagttccaag cgatcataaa cggatggtca 2864641 tgatgtttaa aagcccagct ttccggtatg agcgaaaatc cggctgacag ccagtacaag 2864701 ataaaaccga tatcagtcac gagaaaaaac agcttcatat atctcatttg tactgcccgc 2864761 ttttatgtac cggctcagac accgcaacat gctcgatcag gtttaaagac acaacaccgg 2864821 caataatcaa tccaattgaa atgactttca tgacactcac atgttcttga aaaaacaaaa 2864881 aaccaacgac tgtaatcaag acaattccca tccctgacca tacagcataa gcaactgata 2864941 catcaatgga tttaagcgta agcgtcagaa agaaaagact ccctccataa aagaaaatca 2865001 acagcaaact gggaataagc tttgtaaaac cagacgatag cttcatgctg acagttcccg 2865061 caacctcaaa caaaatcgcc aagcatagaa acacccaatt catgtggcat cagcctcctc 2865121 atcagctgtt ataccgttaa acaaaacatc tacaattgat tcaagtacct ctcctgtcgt 2865181 gaactgatgt ttcagcggat attcagggtc atacacttga ttgatgctcc ctatatacat 2865241 gtgaacaaac aggtccggat tgatgtttct gattctcttt tgctgtttgc actcatttaa 2865301 taatgctagg acaatcgccc attcttcctt aataaacgcg tctaatgtaa gccacgcatc 2865361 gtaatggtat ttctttagtt catttaataa tcccatgttc agcagttcca tcccctgcgg 2865421 aaggctgatc agcatttgtt tcaccttttc gagcacattt aaactttcat tttcatagat 2865481 gtctctttct atttgcttca tttcagctat aaattgttcg acaaccgcct caacaagctg 2865541 atctttagat gaataatatg catagagcgt ccgcttgctc gttcccagcg ctgccgccaa 2865601 atcattcatc gtaaatgaaa atcctttctg cttgatcagc cggaaggttt ccgccagaat 2865661 tcttttatcc atattaatcc cccgctttcg gtaccaagaa aactatttcg gtaccaatat 2865721 tatacggcag aaatttatgg aaatcaacaa tatataaaaa aacctctcct attgggagag 2865781 gtttaaaaga cactgcggac caaaccgccg tccgcccgaa gtgccgcgcc attgatcgca 2865841 gaggaaagcg gactgcttaa aaatgtaacg aagtgggcga tttcttccgg acggatcagt 2865901 ctttgaataa tagatgtcgg ccggttttct ttcataaaac gtgcctcagc ttcttgaaca 2865961 gtcaggtttt caccaggata cagcgagttc agcatggttt ccacaccctc tgttaaggta 2866021 gagcccggca tgacggtgtt gactgtgaca ttcgtgccgg ttgccagctc cgccaaactg 2866081 cgggaaatgg acagctgcat cgtttttgtc gcactgtaat gggccatttc ctgtgacggc 2866141 ataatcgccg cttcactggc aatgaaaatc acacgccctt cttttttctc tatcatgtta 2866201 tgcaaatacc tgcgtgtcag ccttacaccg ctcataatat tcacttcaaa aaaacgaaac 2866261 cattcatcgt cgggaatatc aaagtactcc gccggttcaa aaatccctaa attgttgacc 2866321 aaaatatcaa cctctggata tgcctgaaac agctcattgc agccttcttc tgttcccaaa 2866381 tcaaatgcag ccggataaag aaccgcttca gcatgttgtg ttttcagttc atctatcgtt 2866441 tgattcactt tctcttcccg gcgtccgtta atgatcactg ccgcaccttc ttcagctaac 2866501 gaagaggcaa tagcttttcc gatccctgat gtcgaaccgg tcaccagtgc ggtttttcct 2866561 tgtaaattca gcttcattat tcatccctcc gtttttgatt cctcttattt attgacagaa 2866621 atctgattgg tgaaacatct gctctgcaat cagtatgaaa cagctgggat tgaaatggaa 2866681 gtacgcactt tttggtgcct gtggtttgga gaaaaaataa agcagaacct cttaagaggt 2866741 tctgctttat tgtcagtatg tatggagacg gtgggagtcg aacccacgtc cagaaacatc 2866801 gattacttaa gcgtctacga gcgtagcctg catatttatg gtttcactca tcttcttgcc 2866861 tgcgggcggg ccttccgaga gctagtctgt tcatctcttc ttacgttctc agacgggaac 2866921 gcaagcgtag cctacttgga tgtgctcttc acagacacat aggcaatgtc aggaagagct 2866981 cgctgcgctt attaggcagc taatgctacg ttttggttaa aactgttagt tttgccagtt 2867041 atatttaagt gcgtgtttac gagatcgcct ctcggctcgc agctcaagct cgatccatcc 2867101 ctgtcgaatc cgtaacgtcc ccttggtata agggaaatac gggagaaaat atcaagctct 2867161 cactcaaact ggctatagtc ttattataac atgatcacgg ctcttttcaa ttgtcaaatc 2867221 cttcaaatga atggcgtcgt gatctgatcg tgaacacagt atagcacagg cctgattttc 2867281 gaatcaagca ctatgccttt agaagccttt ttgactgtct ctgaacgctc tttcgatttc 2867341 ccgcttcgcg tccttgcgct tcagatcttc ccgtttgtca tagttcttct tcccttttcc 2867401 aaggccgaga agcactttgg caaagccgtt ttttaaatac agcttcagcg gaacgagaga 2867461 atagcctttt tcctttgtta acccgatcag cttattaatc tccttgcggt gcattaacag 2867521 ctttcttgtc cggagcggat cgtggttata gcggtttccc tgctcatatg ggctgacgtg 2867581 catattgtgg agaaacactt ctccccgttc gattttggcg aaggaatcct taaggtttac 2867641 gcggccggcg cgaatcgatt tgatttcggt tccttgcaga acgatgcctg tttcataggt 2867701 ttcttctata aaataatcgt ggttggcttt cttattttga gataatactt ttcctgaccc 2867761 ttttggcatg ccagaacctc ctctctctaa ggaaaaactg tccacctttt gcgatacgct 2867821 ctattttacc aaatgtcacg taccgctaca atgaaaagct gtttccgaaa gaaagcaaat 2867881 agagcgctgc ggccctattt gctggttgag ctgctatttc ttctttttcc gtttctgttt 2867941 cggagcattc tggaagccgc gttttttctt tttcttcttc ggcttagtga accactcccc 2868001 tttttcctca gacggagctg gagaaacagg tgtattggtg ctttgaacac gttttctggc 2868061 aggctttccg cgttttctgc tccggctgct gtccaattct ctcggacgcc gcggagtgcc 2868121 tttcatgccg acaatttcaa agtcgatatt gcgctcatct ttattgacat cgacaacctt 2868181 gactgtgatt tcatccccga tgcggaagac gttgcctgtc cgctcgccaa tcattgcgaa 2868241 atgctgttcg tcaaagcggt agtagtcatc tgtcataaag ctgacatgga cgagtccttc 2868301 aattgtattc ggcagctcga cgaacattcc gaagtttgtc acagagctga tcatgccgtc 2868361 aaactcttca ccgattttat caagcatgta ttccgctttt ttcagatcat ccgtctcacg 2868421 ctcggcgtca actgcacggc gctccataga tgatgtatgt tcggcgatat ccggcaggcg 2868481 ttcagcccac ttttcctgtg tcgcttcatc gaccttgccg ttgatcaaat acgttcggat 2868541 cagacggtga acgattaagt ccgggtaacg gcggatcggt gatgtgaaat gcgtatagaa 2868601 ttccgttgac agaccgaagt gccccaagct ttgcgggtcg tatttcgcct gtttcatcga 2868661 acggagcata acagtagata taaccgtttc ctctggtctg tcacgcacag cgtccagaat 2868721 gctttgcagc gcgcgcggat gaatattccc cgccgttcct ttcaccacat agccaaatgt 2868781 cgtcacaaat tctaaaaact tttgcagctt ttcagcattc ggctcttcgt gaatccggta 2868841 tataaacggg acattcatcc aatggaaatg ctccgcaact gtttcgtttg ctacaagcat 2868901 aaattcttca atcagcttct cggcgacaga gcgttctctg atcacaacgt ctttaaccgc 2868961 tccttcgtca tcaacaagca cctttgcttc tttgaaatca aagtcaacgg cgccgcggtc 2869021 catccgctta tcgcgcagaa tttgagccag acgctccatg tctttgaaca tcggaacaag 2869081 aggctcgtat ttttgtttca gctcttcatc atcatcaaca agaattttat tcacatctga 2869141 atatgtcatt ctttccgttg ttttgatgac actttggaag atctcgtgct ctgtcacctg 2869201 tccctgactg ttaattgtca tttcacaaga aagcgtcagg cggtcaacct ttggatttaa 2869261 ggagcagatg ccgtttgaca atctgtgcgg aatcatcggg atgacacggt caaccagata 2869321 cacacttgtc cctctttcaa gcgcttcttt gtcaatcggc gagttttcgg ttacgtaatg 2869381 gctgacatca gctatgtgaa cgccaagctt gtagcttcca tcatcaagct tcgtcacggt 2869441 aactgcatca tccaaatcct tcgcatccgc accatcaatg gtgacaatca cctggtcacg 2869501 gagatcacgg cggtctttca gatctttttc atcaatcgtg tcaggcgtac ttgatgcctg 2869561 ttccatcgcg tcagctggaa attctcccgg caggccgtgc ttatgaatga ccgataaaat 2869621 atcaatgccc gggtcgtttt tgtggccgag aatggtttca acctcaccct ctgcgttcat 2869681 gcggccttca ggatagctcg tcagcttgac aacaacctta tgcccttccg cagctccatt 2869741 tttcccattt ttcggaatga agatgtcact cgtgattttt ttgtcgtccg gaatgacaaa 2869801 gccgaagttt ctcgtttctg tatacgtgcc gacaacccgc tgaatcgctc tttctaaaat 2869861 ccgtatgacg gttccttcct gcctggagcc gcttgattgt gagttcagac gcaccatgac 2869921 gatatcgccg ttcattgccg tatttagctc attaggcgga ataaacacat cacttaacga 2869981 cgtatcctca ggcagcaaaa aggcgaatcc tttcgcatgg gctgaaatct ttccttttat 2870041 taaattcatc ttctccggaa tgccgtagcg gtcgcttctc gtccgtacga taagcccttt 2870101 ttcttccaag gcgactaacg ctttgacgag ctctttaaac tcctcggctt ccgtaatatt 2870161 taacatctcc tcaagttcct gaacggtcag aggtttgtac gcctcttcct tcataaacga 2870221 gagaagcttt tccataaatg cttctttttc cattatccga cctcctgttg attaccaatc 2870281 gagcttctct aaaaattcat acacatcctg atggacgagg tcacgttctt tgtcgagtgt 2870341 aatgacatgc cctgattcct cgtaccattt cagctgttta tcatcagttt ccacttcgtt 2870401 gtaaataata ttggcgcttt cggtattaat catgtggtca tgacgggcct gcaccacaaa 2870461 tgtcggtgaa taaatcatat cgacattatt ccgcacatca gcaattaagt cttgcagcgc 2870521 cttgagggta ttcatcggcg ttttttcgaa ttctttcatt tcctcttcaa tttgctccgg 2870581 gcttttcccc tcaaactttt tgtaattgcg agcgtatgaa agaacgcctt gatacatgac 2870641 ctcttcactc ttaatatgca tcggtgcgca cattgggaca attcccttta tgggtacagt 2870701 gtaacccaat ttcagcgaaa aaaccccgcc aagcgacagt ccgcaggcag caatgctctc 2870761 ataaccttca gattttaaat attcatagcc atccattacg tttttccacc agtcttcggg 2870821 ccccgtatgt acaagttctt caggcgggac gccatgtcct tcatattgag gcgcgtggca 2870881 cgtatagccg cgttcattca aatatcgtcc cagcatcctt acatccgctg tatttcctgt 2870941 aaagccatgc agcaaaagca ccgctttgtc tccgccttta aatgtaaatg gttttggtgt 2871001 cacaactttc atgctcatgt ctccctttct atctgcacga tcattttagt tttccacagt 2871061 ttaatcagaa aaaaacgttt tgaatatcat ccagaaacgt gaaaaaggcc tgacttcaca 2871121 tcagacctta tacaaacatt gccctatagg atataagcaa gcgcaatcgt taacacgaaa 2871181 aacaagactg ccagcactac cgtaatgcgg tgcaaaatta aatcaagacc tcttgctttt 2871241 tgtttcccga agagctgctc cgctccgcct gaaatcgcac cagataatcc ggcactttta 2871301 ctggattgaa gcaaaacgac aataataagt gcaatgctga cgataaccaa taaggtaatc 2871361 aaaactgcgt gcatcccata cacctccaga ctcactggct acattacttc tattttacat 2871421 gaaaagggtt ggcatgtcac gctgtatcag acgccaaaag gccggataag acgttttatc 2871481 ttggttaccc tattcatatg aaaaggtcaa aggagaaaag cgatgccgct tatcagcata 2871541 gacagcagga aacatctttt ttatgaagaa tatggacagg gaatccctat catttttatc 2871601 cacccgccgg gcatgggacg aaaggttttt tattatcagc gccttctatc caagcatttc 2871661 agggtgattt ttccggattt aagtggccac ggtgatagtg atcacatcga tcagccagcg 2871721 tctatttcct attacgcaaa cgagatcgcg caattcatgg acgctttgca cattgataaa 2871781 gctgtgttat tcgggtattc tgccggaggc ttaatcgcgc agcatatcgg cttcacccgc 2871841 ccggacaaag tgtcacacct tattctgtcc ggcgcctacc ccgctgttca taacgtaatc 2871901 ggccagaagc tgcacaaact gggaatgtat ctgcttgaaa aaaaccccgg tttgctcatg 2871961 aaaatcctcg ctggcagcca cacaaaagac agacagcttc gcagcatatt aacagaccat 2872021 atgaaaaaag cagaccaggc ccattggcat cagtattatc tggattcgct tggctacaac 2872081 tgcattgaac agctgccccg cctagaaatg ccaatgctgt ttatgtatgg cggcctgcgg 2872141 gactggacct ttacaaacgc aggctattac cgaagatcgt gcagacatgc cgaatttttc 2872201 agattggaat atcagggaca tcaattgccg acaaaacaat ggaaaacgtg caatgagctg 2872261 gtgacagggt ttgtgctgac acatcattca taggaataga aaacgcttgg cttccttgcg 2872321 ttttttgtta ctttattgac ttttgtcaac gaaatcatag taaaaaagat cctcaaattt 2872381 caaattaaaa tagtgaagca ttttaccaat cacaagctgc cccggccttc tttctccatt 2872441 cagcacgcgg ctcagtgtgg cgggtgagac tccgatttcc agcgcaagct gattaaggga 2872501 ataatcgtta ttaaccatat actgcaagac ataatcacgt ctaatctgta tcttttctac 2872561 tggcactttc ctcaccttcc attcctgaaa aacttttttc tatactttta cattacggct 2872621 tatgttaact tttgtcaata catttccagt ctacctattc cctttagtca ataaacatac 2872681 taaaatatga gtaacagtga gggacggggt gagatatatg gaaagctttg gcgaacaatt 2872741 acgggcattg cgtgaagaga gaaagttaac agtcaaccag ctggcgactt attcaggcgt 2872801 aagcgcggcc ggcatctcca gaatcgaaaa cggaaaacgg ggcgttccca aacctgccac 2872861 catcaaaaaa ctggcagagg ccttaaaaat tccttatgag gggcttatgt acaaggctgg 2872921 ttacatcgaa gaagtgcatg aagccagggc cccttatgaa acgaagtgca agctgcttga 2872981 aaaagcggag gcctatgacc tgaaaaacct tgcgcttctt gagaacgaaa agtggcaata 2873041 tctcaataaa gaagatttgc tcatgctgga tcattatttt tcgtttattt cagatgaagc 2873101 gaaaaaacgg tctgctgatg actgactctt gatagaaatg tgaggcgata gaccatgtca 2873161 ccgttcggac agcaattacg ggagctgcgc cgcgcccgca aactgacagt gaatcagctt 2873221 gcggtgtact caggcatcag ctcggccacc atttcaaaaa ttgaaaacgg caaacgcggg 2873281 acgccaaaac ccgccacgat taaaaaactg gcagccgtcc tgaaagtgcc gtacgaaaac 2873341 ctaatggccg ccgcaggcca tattcaggcc tttcctgaag aaatccgcga agcatctgaa 2873401 ggctatcaat ccgtttatga aatttaccag acggctgtca cacgcggagc ggagcacctc 2873461 ccgattttca atagtcaaaa atgggaacat ctctcaaagc aggatattga aaatctcagc 2873521 aaatacttcg attttttgtc ttcagaagca aaaaaacgcg cctcttcctc ataatcccct 2873581 gtttctcttt ctatatttta tcaatcacgc ttgcatgccc tccctcgtta tttgcgttat 2873641 aatagtgaca gacgaggtga aaagtatgaa ccaatcagaa atgtgtccta gatttgaaaa 2873701 agcagtcgac atcttaagta aacgctgggt cgctttaatc gtatttcagc tcttgaacgg 2873761 gtcgcagcga tttagcgaaa ttgaagcagc acttccaaat ctaagcggca gagttctgtc 2873821 agaacggctg aaagaacttg agcttgaagg agtagtgaag cgggatgtca tccctgaaac 2873881 tccggttcgc atcgaatatt cattgactga taaaggaaag gcactagcac ccatattagg 2873941 tgagatttct aaatgggcga ctgaatggat tgacccttcc tttcttgact aattgctaaa 2874001 atggttctga tctcaaagac gagaaaagaa ccgtttttta ttttccaggt gaaaaaaaga 2874061 tatctcagcc gatatatagt acatccacac attacgtttt taaaggagac cactatatgc 2874121 gactgacgat ttcccgcaaa ttcagcctgg tatttttgac actgatcctg atcaatttac 2874181 ttgtaggcgg aataggcgtt cttaatatgc agcatatcat tcaaaaaaca gatgaaatca 2874241 acacaaaatg gattgacggc atcaaaggaa tcacttcaat taattatgta accgagcacc 2874301 tgtcttctaa agaaaaggac tttctgattt atacagacaa aagtaaaatg gatacacttg 2874361 atcaagaaat gaatcaaatc atggaagaca ttaaccaaaa gctcgataac tacgaaaaaa 2874421 cgatctccac tgataaagag cagaaactgt tcgagcagct tcaaactaaa gtgaatacct 2874481 atatggatat tcatgcgcaa attatcgaaa gcggccgcac gaatgacatg gacaaagcaa 2874541 gaggtttatt ggttcagact gaggccagct ttgaggatat gaaaaaaaca atcactcagc 2874601 ttgttgactt aaatcaagaa ggcagcaaca cagcggtaaa agaaacgaag gccgtctatc 2874661 ataaagggct catttacact gctttgcttg tggcagcatc aatcctcatc agcattttca 2874721 tctggcttta tatcacgcga aacattgtaa agcctatcat tcgcatgaag gaatctgcca 2874781 atcatattgc cgaaggcgat ttgtcgaacg atatggaggc cctcaactca aaagacgagc 2874841 tgggtgatct gaatgaagcg ctgcaaaaaa tggtagggaa tctgagagat attgtcggat 2874901 attctaaaga catatcaagc cgggttcttt cttcttcaca ggtgcttgca accgcaacga 2874961 atgaaacaag atccggcagc aaacatatta ccgagacgat gaacgaaatg gctgagggct 2875021 ctgaacagca ggcccaagac gcggtgacga ttgccgaatc gatgaatgag tttaccgaaa 2875081 gcattgataa agcctataat cacggcatca caatcagcga tacgtctcaa aacgttctcg 2875141 aactcgcggt aagcgggaac gaaaatatgg ctacgtcatt acagcaaatg aaaaccatcc 2875201 atcatattgt tgaagaagcc gtgcataaag tgagatcact ggaacagcat tctcaggata 2875261 ttaacaagct cgttcaggtc atcaacggga ttgccgagca gacgaatttg ctgtccctta 2875321 acgccgcgat tgaagctgcc cgcgctggag aaagcggcaa aggcttcgcc gttgtggcag 2875381 aggaggtcag aaagctggct gacggcgttt ctgattccgt gcaggacatt acccggattg 2875441 taaacgggac acagcaggag atccacactg tcattacgta cttggaaagc agctttacag 2875501 aagtcgaaaa aggaacggaa aacctgacag acaccggaca ggctatgcag catatcaaac 2875561 aatccgtcac ccatgttgca gacagcatta aggaagtaac ggatggcttg aagcagttaa 2875621 caaaccaatc gattaccatc aatcaatcga ttgaaaatat cgcttctgta tccgaagagt 2875681 ctgccgccgg cattgaagaa acattttcaa ttaccgagca atccgcccat tcgatggatc 2875741 aagtgcttct aaatgctgaa gagcttgagc agctggccaa tgagcttaat gagaagatgg 2875801 gtcagtttac gatttaaaga gaaaaaagag gctggactcc agcctctttt tctattctat 2875861 gcagctgatt gaacatgttt cgccccggtt ctttttttct tcaccggact taatgcccgc 2875921 tccagccaag ccatgagcaa atccgcccct accgccatca ccgcagttgg tatcgctccg 2875981 gctagaataa tcgcagttcc gtttgttgcg tttgagccgc gtacgatcat gtccccaagg 2876041 cctccggcac cgacaaatgt gccgatcgct gtaattccga tggcaatgac gagagccgtg 2876101 cgaaggcccg ccataatgac agaaagtgcg agcgggagct caaccattct gagcacttgg 2876161 aatttcgtca tgcccattgc ttttccagat tctaagtagg catgttcaat actgataatg 2876221 cctgtgtacg tgtttcgaat aatcggcagc agggaataca gaaataatga tagaatcacg 2876281 gtatttgcgc cgagccccat aacaagcatt aagacggcca gcatagcgag cgccgggatt 2876341 gtttgaataa cgtttgttac ggcaaacacc caggctgaca aacggcgaaa atgcgcgatg 2876401 aggattccgg ccggaacccc gacgacagcg gcaaataaaa cgccgtaagc cgacatgaga 2876461 aagtggcggc cgaattcatc catgacgtaa ctgccattct gcgcgtaata cgtcattaac 2876521 tgttcaagca cgttcattga cctcttcccc ctttcacgat tcgaaatagc gatgtttttc 2876581 taaatattcc ttggcaacga cagacggttc tttgagattg ccgtcgactt catagttaag 2876641 ctcctgcatc gtggctgtgt cgatttttcc gagcattttc ttgatgatgc cttcaagttc 2876701 aggatgttct ttgagcacct tttccggaac aaccggagag cagtcgtacg gcgggaaaaa 2876761 ttgtttatca tcctttagca ttttgagacc ataggacttg attcttccat cggttgaata 2876821 cgcaagcaca atgtccattt ttccgctttt caccgcgtcg tacacaaggc cgatctgcat 2876881 cggatacgtg ccgccgaatg tcatgccgta ggttttcgta aaatcctgat agccgtttcc 2876941 tttgagcttc atccaatagt tatcaacgcc cagctttaat tgcggcgccc attttttaac 2877001 gtctgatacg gtctctaaat ggtattggtc ggccagctcc ttgctgactg taaaggcata 2877061 tgtattatca aacccgtagg agtcatacca ctttaaatca tatctttttt taaactcccg 2877121 ctgagtaagc gccagcgctt tgtccggatc tttttcaggt tccattctca acgtgcctgt 2877181 cagcgcgtct cccgtatatc ttgtggccgc aatgtcgatt tccccgttca ttaaagcctg 2877241 ctgctgcacc gcgttggagc caagattttt aatcgttgtt gttttgagat cagtatggtg 2877301 ttcgatcaac tggccaagca tgctggcgat gatttctgat tcgctcatgc tttgcgcgcc 2877361 gattttaatg gtctggtctg cagcagcgct gagaccagga agcgaacagc cgctcagcgt 2877421 cagcgttgcc gcaagtgcta aacctatcat taatttgaga tattttcttt tcatgagccg 2877481 cctccttatg acaattcctt caatctctgc atgccggcag gtgtcagttt tcgttcagca 2877541 actgccagca cataatcaat cacaattgcc aatatcgtga caggtaccgc gcccccgatg 2877601 atatattccg gctgatataa attcagtccg ataaaaatgt aatcacccaa tccgccgcct 2877661 ccgataaagg aagcaagcgt ggcccagccg attaagtaaa tcgtcgatgt tctgattccc 2877721 gccatgatca ctggtgcggc aagcggcagc tccaccaagc ggacttgttc agccggcgtc 2877781 attcctattc ctttaccaga ctcgagcaga tttttgttga cgccgcgaat gccggtatac 2877841 gtgttgcgaa gaatcggcaa tacggaatag aaaaacaaag ccacaatggc cggaaccttc 2877901 cctacaccaa ggagcgggat aaaaaaagcg aggatggcca gactcggcag cgtctgaatg 2877961 atattgacaa tgccgataat ggtgccggct ccttttttca ttctggtaag cacaaccccg 2878021 agggggacgg caaccagcac acctaagatc acagcaatga gcgatatcgt aatatgctcg 2878081 tatgttttat aaagaagctc tcccccattg gtttgcaaaa attgaacaat atgatgcatg 2878141 acttatcgcc cctccctatg acaatgctgc gagctgcttt tcttctcccc agagggagtc 2878201 atacacgatg tcgaccagac ttgccctcgt cacaattccg atcaggcgtc ggtcttcatc 2878261 cacaacggga acatatttga caccccgttt taaaattttg cggaccgtgt cgcgcagcag 2878321 tgtgccgccc agtactgtgt atatatcttc atgtaaaact tcactgacga gattggcctt 2878381 tttccggcat tgatcaatga tttcaacatc gacatagcct tgcagaacgc gctcgtcatt 2878441 gacgaccagc aatgaatcga cccgttcctg cctcatcagc tgaatggcct cagaaagcgt 2878501 tttatccgcg gtgatcgtta caggctgtgt gttcataatc tggtcaaccc gttcaacatc 2878561 cgggctggat gactgaatca gccgctcctt gccgataaat tcctcaacaa attcgtctgc 2878621 cggatttctt aaaatgtcat cgggcgttcc aacttgaacg atttctcccg cttttaaaat 2878681 cacaatccgg tctgccagct taatcgcttc atccatatcg tgggtaacaa atacgatggt 2878741 tttatgtaag gttttttgca gttttttaaa ttcttcctgg agggaatccc tcgtaatcgg 2878801 gtcgagtgcc ccaaacggtt catccattaa gataagcggc ggctccgcgg caagtgcccg 2878861 taatacacca attcgctgct gctgcccccc gcttaattca tgagggtaac ggtctacata 2878921 ttctggcccc atatcgacca attttaaaag ctcacgcgcc cgctctttcc gctgctgctc 2878981 cggccatttc agcagttttg ggacgagtga gatattctgc tgaatggtca tatggggaaa 2879041 caggccgatc tgctgaatca catagccaat tttgcgcctg agctctacag gatcctggtc 2879101 catgatgttt tcgccgtcaa tgaaaatctt cccggcggaa ggctcaatta atcggttaat 2879161 cattttcatt gttgtcgttt ttccgcagcc gctcggcccg ataaagcaga taaattcgcc 2879221 ttttgcaatc ttaagattta cgttgttcac ggcttttttg ccgcccttgt atgttttcga 2879281 gacattttct aatgtcagca aacatcgcac ctccaaaatt aagtttattc aatttgttca 2879341 gtttaaattt aatttttcag acaattgaat gcttcccatt atagaataaa gtttataaaa 2879401 taaaaagttt acaatttgtt catattattt ataaagtatg tgtaaacgct gatttacccg 2879461 cattgacgtg tgttgatctc cttattgctc caatttcctg ccaaattctc ttttgacagc 2879521 attttcgccg tatcaaaaat gtggtatatt gacatcggaa ttgttagctg aaaggatgaa 2879581 accgttggag aaagatccgt taacgatcat tgaacaagcc gaggaccatt ttatagaaag 2879641 aatcgcggaa aacatgcatg catttggaat gccctctacc gtcggacgag tgctgggcat 2879701 tatttatatg aatcgaaaac cgatgacgct tacggaatta tctgaggcca ccggcatgag 2879761 taaaacacgt atgagccagg tagtgcggga aatgcttgat gccaacattg ccgagaaggt 2879821 attcgaaaaa ggcgtgcgaa aagatttata tgaggttgag caggactact atcaaacatt 2879881 tatcacgctg ttttcagcca cctggagcaa agtcgtcagc aaaaacaaaa tgatgcataa 2879941 aaaactcaat cgggagctgc ttagcgtgtt ggatgaagag cttactcctg aagcggaaga 2880001 aaaagtgaat gagctgctga aggaattaaa ggaatggctc gattattata attggctcag 2880061 ccgtttgatt gagttttttg agagcgaaga catttttaaa tatgtgccga agccgtaaaa 2880121 agttcccaaa ttcaattctg ggaacttttt taagtccaat ccaaatggtt gaatatcaaa 2880181 cttcgagctc ccaacgctgg aaaatatgtt taacagatac taacacatgt tgtttattta 2880241 aaaaaaccac ctctgttgta tttaaataga ggtggttttt ctatcagcta taataaaatt 2880301 tccttttttc tttttaatcg ggcttaatgc tcgttcaagc cagcccatga ccaaatcggc 2880361 aatcaccgcc atcagagctg tggggatcgc tcccgctaat ataatcgcgg ttccgtttgt 2880421 ggcgtttgat cctctgacga tgatgtcccc gagaccgcca gcaccgacaa atgtcccgat 2880481 ggccgtaatg ccgatcgcaa tgacaagcgc ggtgcgcagg ccggccatta tgacagaaag 2880541 cgcaagcgga agctcgacca tccgcagcac ttgaaatttt gtcatcccca ttgcttttcc 2880601 cgattcaaga taggcgtgct caatactgat aatccctgta tacgtatttc tgataatcgg 2880661 cagaagagaa tacagaaata atgacaatat caccgtatta gcgcccagcc ccatgacaag 2880721 catcagcacg gcgagcatgg cgagagccgg gatggtctga atgacattcg tgaccgcaaa 2880781 aacccatccg cttaatcttc tgtatctggc tatcaggatg ccgagcggaa ttccaacaat 2880841 ggcggcaaat aaaacgccat acaccgacat cagaaaatgg cggtaaaatt cctgcagcac 2880901 gtaaccgccg ttttgcgaat agtatgtgcc aagctgctgt agtacttcca tatgatccac 2880961 ctcttttctt agtcaaaata atgatgtttc tctaaaaatt cctttgctac gacagacggc 2881021 tccttcagct tgccatccac ctcataatta agttcctgca tcgtttccgt gtcgatttgc 2881081 ccaatcagct tattgatcac accttcaagt tccggatgct ccttaagcac cttttccgga 2881141 atcaccggtg aacagtcata cggcggaaag aaacgcttat cgtcttttaa gattttcaga 2881201 tcatatgctt taatccgtcc atccgttgaa taagccaaaa ccgcatccat tttcccgttt 2881261 ttgactgcgt catagactag cccgatctgc attggataag ttgtgccgaa ctcaaagcca 2881321 tatgtgctga caaagccttt atacccgtcg ccttttcgtt tcagccaagc attgtcgacg 2881381 cctaatttat attgggaagc atttttcttc aggtcagaca cggtgttaat atgctccttt 2881441 tccgcaaact tttttgttac ggtgaaggca tatgtgttat caaagccgta ggaatcaaac 2881501 catttataag aaaagcgctt ttgaaactcg ttctgcacaa tgttcagcgc ttttttcgga 2881561 tctttctccg cttccttgcc gagggtgctt gttaaatctg ttccggaata gcgcgtggct 2881621 gaaatatcaa tgtcaccgcc cagcatcgct tggtgctgaa catagtttga gccgaggttt 2881681 ttcactaaag cagtattcaa atctgtatca tgttcaataa gctgcgcgat catattcgct 2881741 acaatttctg attctgtcat gctctgcgcc ccgattttga tcgtatcgtc agaagcgccg 2881801 cctagacccg gcagagagca gccgcctagc agcatgacaa agacgagagc aaacgcgcca 2881861 agccatttga tttttgtcat tttcaacagt gccaactcct tacgatactt ccttcatccc 2881921 ttgcaagcct ttcggcgtca cctttcgttc tgtcacagcc agaacataat caataataat 2881981 tgccagaatt gtgacaggca cggcaccgcc aatgatatat tcaggctggt ataggttcag 2882041 tccgataaaa atatagtccc cgaggccgcc tcccccgata aacgacgcaa gtgtcgccca 2882101 gccaattagg tagatcgttg atgtgcggat ccccgccatg atgatgggaa tcgccagcgg 2882161 gatttcaacg agccgaatct gctcccagcc ggtcatgcca attcctttcc ccgattccag 2882221 gaggttttta tttacacctt taatgccggt atacgtattg cgcaggatcg gcagtaccga 2882281 atagaaaaat aaagcgacaa tcgcaggcac ttttcctacg ccgagaagcg gaataaaaaa 2882341 ggctaaaatc gccagactcg gcagggtttg cacaatgttt acgaaaccga taaccgcacc 2882401 tgcgcctttt ttcattctgg taagagcaac gccgagcggc actgcaacga taatgcccaa 2882461 tacaacggct atgagtgaaa tatataaatg ctctcctgtt ttatacagca gctctccgcc 2882521 gttcgtttgc aaaaaagtca tcatttgatt catcttaaaa gagctcctcc cctggtcaga 2882581 tcgtcatgag ctggttttcc tcgtcgcccc aaatggaatc gtatacgata tcaacgaggc 2882641 tcgctcttgt cacaatccct gctaaatggt tctgttcatc gaccaccgga acatacttga 2882701 tcccctgctt caaaattttt cggactgtat cgcgaagaag cgcccctttt tgaacggtat 2882761 atatatctga acggtataca tcgccaacga tgctcgcttt tttgcggttt tgatcaatca 2882821 tttccacatc aacatagccc ttcagcacgt tttgccggtc cacaacgagc agcgagtcaa 2882881 cacgtttttc tctcatcagc tgaatcgcct gagaaagcgt tttgtccgca gataccgtca 2882941 ccggcgttct gttcatcatt tgctctaccc gctcgatatc cggtcttgac tgaatcaggc 2883001 gctctttccc gataaattct tcaacaaact catttgccgg gtttcgaaga atctcatcag 2883061 gtgtgccgac ttgaacgatt tctcccgctt ttaatatcac aatcctgtca gcaagcttaa 2883121 tcgcttcatc catatcgtgg gttacaaaca caatcgtttt gtttaaggtt ctctgcagtt 2883181 ttttgaattc ttcctgaagg gaatcacgcg taatcggatc aagcgctccg aacggttcat 2883241 ccattaaaat gagagggggt tccgctgcca gggcgcgcag cacgccgatt ctctgctgct 2883301 gtccgccgct gagctcatgc ggataacggt ctaaatactc tgggcccata tccacaagct 2883361 ttaacagctc gcgcgcccgt tctttccgtt tttcctcagg ccatttcagc agctttggta 2883421 cgagtgagat gttctgctgg atggtcatat gggggaacaa accaatctgc tgtatcacat 2883481 agccgatttt tctcctcagc tcaaccgggt cctgttccat aatattttct ccgtcgataa 2883541 agatccttcc agacgatggt tctatcagtc tgttgatcat cttcatcgtc gtcgtttttc 2883601 cgcagccgct cgggccgata aaacagataa attcaccttt tgcaatatct aaatcaatgc 2883661 tgttcacagc ttttttgccg cctttatata cttttgacac ttgttccaat ttcagcaatc 2883721 cgtgcacctc cgcaggtttc ctttaaattt tctgaaaagt ataatcctta ttatagtttg 2883781 aactttgtaa aataaaaagt ttacaatgtg ttgaaattat atgttattta tagattattt 2883841 attgttatga ccgagacgga aagggtgttc ttacaattac tccggatacc tcccacttcc 2883901 tctgcattca gctattttca acaccaggaa gaaatatgat atattgacac catcaattgc 2883961 catttgaagg gatgatcagc tgtgaaaaaa accgctctcg acatcattga acatgctgaa 2884021 gagcatctca ttgagaagat tgccgaaaat atgcatacgt ttggaatgcc ttcaactgtc 2884081 ggacgtgtgc tcggaattat ttatatgaat cgaaaaccaa tgaccttaag cgagctctct 2884141 gaggcaacgg gcatgagcaa aacacggatg agccaggttg tccgggaaat gatcgatgcc 2884201 aatatcgccg aaaaggtgtt tgaaaaaggc gtacgaaaag acctttatga cgtcgagcag 2884261 gattattatc aaaccttcat ttctttattt gcggcgaatt ggacaaaggt cgtgagcaaa 2884321 aacaaagtgc tgtataaaaa attaaaccgg gagctgagtg atcttttaca aagggacggg 2884381 cttaccccgg aagcggaaga gaaagtcaat cagctgctga atgaattaaa agaatggctt 2884441 cattactatg attggctgag caggttgatt gaattttttg agagtgagga agtctttcgg 2884501 tatgtgccga aaacaaaaga atgcagctct ctaaaataag agagctgctt tttgcatcat 2884561 gaagttaaga ccggaaacat gcctttcagc ccggcaccaa tcatcccgac cgcaaccacg 2884621 gctaagatta atcccatcag tctggtaatc acattcatct cggtttttcc gagtttgctg 2884681 ctgataaaag cagaatagtg gaaaaagaga aaggtcaggg caataacggc ggctatgccg 2884741 atcatgacag ccgcataatg accaatgccg ctatgtccgg cggaaaggct catcactgtt 2884801 gcaatcgttc cgggcccagc aatgatcgga atggataaag gtgtgactga tatatccgct 2884861 ttttccttgc tttccttatg ttcatcatgg tgaagagatt gcacgtgcga ttctttcgca 2884921 ttcaatagat tataggcaat gccgaaaatg aatatgccgc ccgccactcg gagcgcgtga 2884981 atgttgatat caaacagttt aaagataaga tgaccgaaaa ccaaaaaagc tgcgagaata 2885041 aaaaaggata aaatagctgc cttccgggca atcgcttttc tttccgctgc agtatagcct 2885101 tctgtcagcg tcagaaatat cggtacgttt ccgatcggat tcgatactgc gaataaagaa 2885161 atgaagacgt gaacgataaa tgagaacatc atatacctcc ttgttgatag tctctgcaca 2885221 ggaaatagaa tgattctcca cccttttacc cggaggcgat ttcccggtaa acctttatag 2885281 cctgtcagaa acgcgccatg ctacaatgaa gtgacaaatt gaataggaag gacgtataca 2885341 gatgttcaaa aaaattgcgg cagatgcctt gggcttatct gatatcggaa aaattatcga 2885401 acctcaggac tatgacaaaa cagacgcaga tgactatgtc atgcatgaag ataatgagaa 2885461 aatttatttc ttgattaaaa caaaagcaga cgagtattgc tttacgaacc tggccctgat 2885521 ccatgtggac ggcgaacgcg ccacttcctc aaaacgaacg ttgaaacgct atccttattc 2885581 gcaatataaa atctctgacg tttttcttga aactgccgga aaagtggatt tggatgttga 2885641 aattaagttc aagctgggcg gtgaacaatt cgacattgat gtccacaaag accagattga 2885701 aaagttaaaa gacctttata aagcactgct tcgcatcgct gaaacaacct atgaaaatga 2885761 cattttaatc aatcaagcgg agcaaagctt agataaagca gtgacgattc ttcaccatac 2885821 ccgccctgag cacgtcaata ttgaaacgca atacaaagag ctgaccgaat tcggattcac 2885881 ttggctgaca tccgttcgct cgcagtatca tattaaggat tttggggatg tatttgagaa 2885941 atatattaat aactagataa aaaaagacac agctgctatc gtgctcgtgt ctttttttgt 2886001 atgaatattg attactttac aacttttttc ttttataata aaactattag tctattttcc 2886061 ctatattaca gataaaggag ttattttatg tattgtcctc aatgcggcca tcaaacagat 2886121 ggcggaaatt tttgtgagaa atgcggatca ccgctccccg gtcaatcagg ccaccagcat 2886181 gcagctcaaa ctggagccgc tgcaaagcaa gcagcaaaac agttcggttc atttgtctta 2886241 tccgtcctga aacgccctta tcaggaatgt aaagcaacag gcggagaaca gctgatcagc 2886301 gcaatcatta cgatggttct tttcagtttg ctgacccctt tgatgtttta tattcttttt 2886361 tcagacggtc ccggaagcgt aagctttaca gcaatcttct tagagccaac catttatttt 2886421 attttatttc tatttggcct gcatgcatgc atctttttcg ccctgaaaat cgcgggaaac 2886481 caagtgtctt tcaaggattc attctcaaga ttcggagcat ttcttattcc ttttacggct 2886541 attttgattc ttgccctttt cttcttttta ttacatacag acatttgctt taccatatta 2886601 gccgttggtt taatcggtgc attcttcgcc attcctcctg cgatgctgag cagttaccag 2886661 cattcatata aagggaaggt tgatttcatt tactcaacga ttgtgattta tctgatcatc 2886721 tgcgttacat ttcagcttat tatcgaacac tatgtcaaag aaattttccg ttatatgctc 2886781 ttttaaaaac aaccccatca cctgctggtg atggggttgt tttattgaat agacgttaag 2886841 taaattcttc cgttcttcac tacgccggtg taggtccagt tatatgttct gagctttgga 2886901 ctgccgcctg attttgtgat atagaattct tcatacgtct taatcgtgat agccgaccca 2886961 ttttggctcc agcttttcac ttcatagtta ttaaagtctt ctgttgtccc ctctttattt 2887021 aatttcgaca cgagatgctg ctggtcggaa taaagggaac tgcctttttc aaggctgtct 2887081 tccatcagtg agaaattatt ttgattcacg gcatctgcct gactttgcag ataactgccc 2887141 ataaataatg tcacttgttc atctgtaaca tcgccgcttg cagagctttc actgcctttg 2887201 tttttcgagc cagcccaggc ggaagtgtat gtctctggtt tatcattttt gattttcttt 2887261 atatttgtgc ctgcagattc gaatgttgat tctgcatctt cgaaaatcca ctttttctgt 2887321 tttttatcat atgaaagaag atattcataa ctcggactgt cgtcagtcat ttcagacttt 2887381 gtatagtcgt tatacgaaga agactggtga agttcttttc ctgttaccga tacctgccac 2887441 gttccgtcgt ttttctgaga gagggcaaat gtgtccaggt caaaatcagt ttccaagtat 2887501 ctatctttta agtatgaatc cgcgcttttc atagaatcga cggtgtcctt cgtctccgcc 2887561 ttccaattgg cacttgcctc tgtcatctgg gctgtattcc catcagatag agctttggag 2887621 tattgttttg ttgttttgac aattgtgttc ataatctgtt cctgtgtatc ttgatcagga 2887681 attaacgtta actccatttc tttatcatcg atcggaacgc cggcagtttt tgtttttccc 2887741 cacggaaatt ctgcctcgac tgaagctgtc attgatccat ctgtcagcag cggaccatat 2887801 gttacggatt tgaacggatc tttatgaatt gatttaccgt taatcagcaa atctcccttc 2887861 ccgctcttga tgtcattcgc taagctgaat gtcacatcgt ctgcttccaa tgagagatca 2887921 acacgaaagc tgctatcgcc aatcgcctga atgtcttcct ttttcacaag gtcaacgaca 2887981 tcgtttttca gtttggctga gactgtatat tcgccgggaa tgtacggacc aagggtttgt 2888041 gcttgatctg ctttctttac agatccggct tcctctttat tgacatatag atcggtattt 2888101 ttataattgc tgctcacttc aaaataaaca ggtgctacct ttaagtcata atggtcaaat 2888161 accagcaggc ttttcccgtc tttttccgca tatacgatat ccttctgggc tgtttcatca 2888221 cgcagcgatg caaaaagttc atcttttttg tctggatgat ccttcaaata tgtaagaaac 2888281 ggttttacat tatttttagt gagtttaaga ttgtcattta ccggtgtaag cagagtcgcg 2888341 atttggtcct gatccccatc atttacggcc tgttcaaact tgtctactaa cctatccttt 2888401 gaagtaaaat acgctccggt tttatatgcg gcgaataata taacgcacgc cgcggcaatg 2888461 ctgctccata aaatgatggt tttcttaggg atcggttttc gcggagcctg cctcgtttct 2888521 gcagtgctag ctgtttcttg atttgcctgt ttgctgcccc ctccgatcgg ggtgccgcat 2888581 tgtttacaaa acttggctcc ttcattattc tgggagccgc aattcttaca aaataacatg 2888641 actttcctcc tattctacta atttgataac atttactgct tttcatattt tataataaaa 2888701 cagaatgaaa ttgggaacga atgaaaaaat taaatgtcta tcagactaaa aaggtggaat 2888761 gaatatgcaa aagctcagga ttgaattagg agaagaaaca aatgacgaat tatatgatct 2888821 attgctgctc gccgatccat cgaaagacat tgtagatgaa tatcttgaga ggggagaatg 2888881 ttacacagct tgggccggtg atgagcttgc aggggtttat gtattgctaa aaacaaggcc 2888941 gcaaacagtt gaaattgtaa atattgcggt aaaagaatct cttcagaaga aaggctttgg 2889001 caaacagctt gtacttgacg ccatcgaaaa agcgaagaag ctgggggcgg acacgattga 2889061 aatcggaacg gggaattcga gcattcatca gctttccctc tatcaaaaat gcggattccg 2889121 cattcaggcg atcgaccacg atttctttct cagacattat gatgaggaca tttttgaaaa 2889181 cgggattcaa tgccgcgata tggtaaggct ttatttggat ctctgaaagc ataaaaaagc 2889241 cgccgagaga aaatcccggc ggtcttttta ttacttgttt aagttgtaga aagagttgat 2889301 accgtggtat tgagcagttt cagccaactg atcttcgatg cgaagaagct ggttgtattt 2889361 cgcaacacgg tccgtacgag acggagcacc tgttttgatt tgtcctgcgt ttgttgccac 2889421 agcgatgtca gcgattgtgc tgtcttcagt ttcaccagaa cggtgagaga taacagctgt 2889481 gtagcctgcg cgtttcgcca tttcgatcgc atcgaatgtt tcagtcaatg taccgatttg 2889541 gtttactttg atcaggatag agttgcctac gccgttttta ataccttcag aaagtttttt 2889601 cgtgtttgta acgaagaggt cgtcaccaac aagctgaact tttttgccaa gacgctcagt 2889661 aagaagcttg tggccttccc agtcgttttc gtcaagtccg tcttcgatcg agatgattgg 2889721 gtatttagaa acaagctctt cataccagtc aaccatttca gcagatgttt tcacaacgcc 2889781 ttcgccagac agatggtatt tgccgtcttc tttgttgtag aactcagaag atgcagcatc 2889841 catagcaagt ttaacttctt cgccaggttt gaagccggct ttttcgattg cttcaacgat 2889901 tgtttgaagc gcttcttcgt tagaaccaag gtttggagcg aatccgcctt cgtcacctac 2889961 agcagtgttt aagccttttg cgcttaatac tgatttcagg ctgtggaaga tttgagcgcc 2890021 catgcgaagt gcttcacgga agttaggagc acctacaggc atgatcatga attcttgaat 2890081 atccacgttg ttatcagcat gctctccgcc gtttacgatg ttcatcatcg gtacaggaag 2890141 cgtttttgag ttgaatcctc caaggtattg gtaaagagga atctgtaaga aatcagcagc 2890201 agcacgcgca caagccatag atacgccaag gattgcgttc gcaccaagtt tgcctttgtt 2890261 ttcagtaccg tcaagctcga ttaaaagctg atcgattgcg ttttgttcag ttacatcaaa 2890321 gccaagaagc tctggagcaa tgatttcgtt tacgttgtta acagctgtta acacgccttt 2890381 tccaaggtaa cggtctttgt cgccgtcacg aagctcaacc gcttcgtatt cacctgtaga 2890441 agctccgctt ggcactaatg cgcggccgaa agctcctgtt tctgtatata cttcaacttc 2890501 aactgttggg ttgccgcggg agtctaatac ttcgcgtgca taaacatcaa caatgtatgg 2890561 catgagtttt gtctctcctt ttgattttca aattattttt gaattaaaga tgttcctgtc 2890621 atttctttcg gtttttcaac accaagaagg tctaataacg ttggtgcaag gtcgcctagg 2890681 attccgcctt cacgcagcgt aatgccttct ttcgttacaa tcacagggac tgggtttgtt 2890741 gtatgcgcag tgtgcggttc gcctgattct gtaatcagaa tgtcagcatt accgtgatca 2890801 gcggtaatga tagcgtgtcc gcctttagca aggatcgcgt caacgacttc gcccaagcat 2890861 tcgtccactg cttcaattgc tttaattgtt ggttcaacca ttccggagtg gccgaccata 2890921 tcagggtttg cgaagttaag aatgatcgcg tcatgcttgt cagcttcaat ttctttgaca 2890981 agcgcgtctt tcacttcata cgcactcatc tcaggcttca agtcatacgt tgcaacttta 2891041 ggcgagttga tgagaatacg ctcttcaccc gggaattcag cttcacggcc gccgctcata 2891101 aagaacgtga cgtgcggata cttttcagtt tctgcaattc gaagctgttt taacccgtgc 2891161 tgagataata cttctccgac tgtgttatca agatttatcg gtttaaacgc tacatagccg 2891221 tcaactgttt cactgaagtg agtcaggcag acgaaataca ggttctttgg ataattctcg 2891281 ccgcggtcga agtcacggaa gtctttgttt gtgaacgtgt tggaaatctg gatggcgcgg 2891341 tccggtctga aattatagaa aatcacagaa tcgccgtctt ggattttcgc aacaggctca 2891401 ccgttttctt ttgtgatgac agatggaatc acgaattcat cgtagatacc atttgcatat 2891461 gaatcatcaa caacatccag ggcgctgcgg taagatgggc cttcgccgta cgccattgcg 2891521 cggtacgctt tttctacacg gtcccagcgt ttgtcgcggt ccatagagta gtaacgtccg 2891581 gaaatgctgg cgatttcacc tacaccgatt tccttgattt gatcgttcaa ctggttgatg 2891641 tacgttttcg ctgtctgcgg acctacatca cggccgtcaa ggaagccatg gatataaacc 2891701 tttgtcagcc cttctttttt cgcaagcttt aacagtgcga ataaatgatt gatatggctg 2891761 tgcacgcctc cgtcagataa aagaccgaac aggtgcaagg ctttgttgtt ttctttcgcg 2891821 ttgctgatcg cgtcaaggaa tgtttgattg cgttcgaact ctccttcacg aatggcaaca 2891881 tttacgcgtg ttaagctttg gtacacaata cgtcccgcac cgatatttaa gtgacctact 2891941 tcggagttcc ccatttgccc ttcaggaaga cctacagcct cgcctgaagc agtcaaagtt 2892001 tgatgaggat actggttcca atagcggtca aaattcggtt ttttcgctaa agcgactgcg 2892061 ttccctactg tttcgttacg taatccgaac ccatcaagaa tgatgagtgc agctggtttt 2892121 ttactcatat tgaccttcct ccaataattg aacgaatgac tgtggctcaa ggctcgcgcc 2892181 gccgaccaaa gcaccgtcaa tatcggactc tgccatatat tctttaatgt ttgcaggctt 2892241 tacgcttccg ccatattgga tgcgaagctt gtctgcagct tcttggctga agctttcagc 2892301 gacggtttta cggatatgcg cacacacgtc attcgcatct ttcgctgtag aagatttgcc 2892361 tgttccgatt gcccagattg gctcatacgc aataacagaa gcagcaactt gttcttcaga 2892421 aagaccagca aggccttttt tcacttggtc agcaacaaga tcatttgttt tgccggcttc 2892481 acgctcttca agcgtttcac ctacacagat gatcggcaca atgccgtgtt tgaaagctgc 2892541 gtgtgctttt ttgttaactg tttcatcagt ttcagcgaac atttcacggc gctcagagtg 2892601 gccgatgacg cagtagtcaa cgccaaggtc tttcagagca accgggctga tttcgcctgt 2892661 gaacgcgccg ctttcttcga agtgcatgtt ttgagcgccg acttttaggt cagtgccttt 2892721 cacagcagaa gcaagctttt ctaagaaaag cgctggcgcg caaacaacag cttcagcttt 2892781 gtctgctgct ggaatggaag atttcacttc ttcaacgaag ctgacagctt cgccgagtgt 2892841 tttgttcatt ttccagttac cggcgataat tggttttctc atctgttcca cttccttata 2892901 gcagttttga gattatttat cgttcagtgc agctacccct ggaagctctt tgccttccat 2892961 aaactcaagg gatgcgccgc cgcctgttga gatgtggctc attttgtcag caaggccgaa 2893021 tttttcaacc gctgccgcag agtctcctcc gccgatgaca gagtatgtat ctttcgcctc 2893081 tgccaatgct tccgcaaccg cttttgttcc ttgagcgaac aagtcgattt cgaatacgcc 2893141 cattggtccg ttccacacga caagtttgct gtttttgatg acgtcagcat acgtttcgcg 2893201 tgttttcgta ccaatgtcga ttgcttctaa atcactaggg atttcagaga tcggcacaat 2893261 tttcacgttt gcatcgttag agaaatcatc tgcaacgagt acatcttcag gcatgtagaa 2893321 gttaacgcct ttttctttag cgcggtccat aaatgatttc gcaagctcga ttttatcctc 2893381 ttcaagaaga gatttcccga cttcatagcc aagcgctttt acgaaagtat aagcaagacc 2893441 tccgccgatg atcaggttgt ctactttatc aagaagactt tcgattacac cgattttgtc 2893501 ttttactttc gctccgccga tgatcgctgt gaacgggcgg tcaggattgg aaaccgcttt 2893561 tccaagtaca tcaagctctt tttccattaa gaaacctgca actgctggca gatgctcggc 2893621 aattccagct gtagatgcgt gagcacggtg ggcagcaccg aatgcgtcat ttacatatac 2893681 atctgcaagc tcagcaaatg cttttgcaag ctcaggatca tttttctctt caccaggata 2893741 gaaacgtacg ttttccaata caagaacgtc tccgtccttc atctcagaaa tttgtgcttt 2893801 tacagcatcg ccgtatgctt catccgcttt tttcacttct ttgccaagca gttcgccgag 2893861 acgtgcagcg acaggagtta aacgaagctc ctcaaccact tcgcctttcg ggcggcctaa 2893921 gtggctcgca agaaggactt ttgcgccttg gtctgcaagg tgtttgattg ttggaagcgc 2893981 agcacggata cgtgtatcgt ctgttacttc cccgtctttc attggaacgt taaagtcaac 2894041 gcggcagaat acaactttgc cttttacgtc gatgtctttg agagtttttt tattcatgcc 2894101 taggagatcc tccttcaaaa tggtttgcat acagcacgaa aaacgtgaaa ccgtctgttc 2894161 aagcgataac tccgctaggg cagatcgcag tctttttcgg cacagggcag ttcgtctaaa 2894221 agccagggca gcggccttag gcgaaagcgc cggcaaagct gcttaaaacg cggtcgtttc 2894281 tctatcacag agcgttttct gaaagccggt cttcatggaa aaagggaaag ggagtccgtc 2894341 cccttccctt gtccgctttc attatagcgc ttctattcga aagaaccaag tcaggtcctt 2894401 tttcagctat aaattaaaga cctttttttg cgatgtaagc tgcaaggtca acaacgcggt 2894461 tagagtagcc gctttcgtta tcgtaccaag agattacttt taccatgctg ccttccataa 2894521 ccattgtaga aagagcatcg attgtagaag agtttttgtt tccgttgtag tcgccagaaa 2894581 ctaatggctc ttcgctgtag ccaaggattc ctttaaggtc gccttcagcc gcttctttaa 2894641 gagctgcgtt tacttcttca gctgttactt cttggttcag ttcagcaacc aagtcaacta 2894701 gagaaacgtt tggagttgga acacgcattg ctccaccgtt cagtttgcct tttagttcag 2894761 gaagaactag agaaactgct ttagcagcac cagttgatgt tgggatgatg ttttcagctg 2894821 ctgcacgcgc acgacggtag tctttgtgcg gaagatcaag gatttgctga tcgtttgtgt 2894881 aagagtgaac agttgtcatc ataccgcgtt tgatgccgaa tttatcgtta agtacttttg 2894941 caaacggcgc aaggcagttt gttgtgcaag atgcgttaga gataacatcg tggttagccg 2895001 catcgtattt atcttcgtta acacccataa cgattgtgat atcttcttcg ttagcaggag 2895061 cagagatgat tacttttttc gcgccagctt ctaagtgttt cgcagcgtct gcgcgttttg 2895121 tgaagaaacc agtagattca actacgattt caacgccttg tttgccccag ctaagtttag 2895181 caggatcgcg ttctgcagaa acttcaattg ttttgccgtt aacaacaagg ttgttaccgt 2895241 caactgaaac ttcagcgtct aattttccgt gtacagaatc atattgtaaa aggtgagcca 2895301 gcatgttagc atctgttaaa tcgttaaccg ctactacctc aacttcagga ttgtttaatg 2895361 ctgcgcggaa tacgttacgt ccaatacgac caaaaccgtt aataccgact tttactgcca 2895421 tgattgtttc ctcctttaaa taagtgagag atatttatat tgagggatta ttcatccctt 2895481 aataacttct ttgcggctcc ttcgtctgtg acgagaaccg tgttgcgtgg ctttttaaag 2895541 taagcctcga tcgcttcggc ttttgatgat ccgcccgcta ccgcaataat atcggggatg 2895601 gcgtctatgt catccagctg cattccgaca gaatgcactt tgtgaaccac ttcgccgtcc 2895661 gcgttaaaat agtagccgaa cgcttccgtc accgcgtcgt tatcatctat tttctttaaa 2895721 tcttctaaag gcgtgtttct gcgctgagcc atagttttag cttcgccgat tccgtgaacc 2895781 agcatactcg ctgatttaat ggtgttcagc acctctttga cagaaggctc ttcaataata 2895841 gatgaatagg cgccttgtga cagctgtccc ggaacaaaca aaagccggta agtgcctgaa 2895901 gccttctccg ccatatgcgc gcatatggtg ttcgcctggt ttttcacgtc ttcgcctaaa 2895961 ccgcctcttg caggcacaaa caaaagctcg cggtttttag aatccggcgt catcatttcg 2896021 gcgacagctt caattgtcgt accgccagtt acagcgacga tatttttgcc tgaaaatctt 2896081 tttttcatac atgcgacagc cgctcttccc atttcttttt tgacccatgg ggattgatcg 2896141 ctgtctccgg atacgataat ggcatccttt agatttaaac gttcttttaa tgtcttttcc 2896201 aaaagagtca aacctaaaac atctttcatc gtatcttcca aaacagaaag cagttcatag 2896261 ccctcttctg tcaatgtcat gccgtttgtc ttaatatcga ccaggttctg ttcctttaaa 2896321 aactgaacct cgcccctcag cacacgctcg ctgattccga gactggcaga caggcttctt 2896381 cgcccgatgg gttctgtcag cctgatatac tgcaagattt caaacctctt ttgcataacg 2896441 agcagaagat caggcaataa ttttttttga gcttgtatta actggttcat gactcaaacg 2896501 ttccttcctt ttttgctgga cattatatgt cccgctatga caaaaaacgt cccgtcatag 2896561 ccaaaaaaaa tcatttctgc tttctttaat tattttaaca gggtggaatt gtttattcaa 2896621 ctgttaagag ccaattcatc gacaatattc gcagagtttt catgccgcgt cgttttatcc 2896681 agcaatattt tatcctatat atctttatct tatacagaaa gcgccaaatg gtgcatccca 2896741 atataaacag cccttcccgt agaaagggct gtttcattaa agcgttttca ttttatccaa 2896801 agcttttcaa tttcctcgag cgatttgttc ttcgtttctg gacagatcgt aacgacaaac 2896861 aggaaacaaa ggatgttaat caccgcaaag atccaaaatg tataggcgag cccgaaagaa 2896921 tcgatcatca ttggcacaaa ctgtccgatc gcccagtttg ctccccataa aaagatggtc 2896981 gcaatgcccg cggcccgcgc acgcagatgg ttcgggaaga tttcagaaat cataatccat 2897041 gtgatcggtc cgaccgagac acagaaagca gcgacaaaac ctaatataag gacgatcatc 2897101 atgatcccgc ttgttaactc aaaataaaac gacgtcccga ttaaaatcat aaaaatagcc 2897161 ataaaagcag aaccgatgga catcagtttt tttcgtccga ctttatcaat cagcaacacc 2897221 gcaataacgg taaaaataac ttctacaacc ccgacgatac aagtcgtcac aaatccggcg 2897281 ttttgcccga atcccatcat tttaaagatt tccggcccgt agtaagtaat cgcgttcatg 2897341 ccgatgactt ggttaaacag cgccagcagg attccaatga caagcgcctt tctgagaccc 2897401 ggcttaaaca gctgggagag cgaccccatt tgttctattt ttaaagagtt ctcaatgttc 2897461 tttaattctt cttttgcaac agtttctcca ttaatacgtg tcaggatctt taaagcttca 2897521 tttgttttgc ccgctttcgc cagccatctc ggactttccg ggacgacgag caggacaagg 2897581 aaaaaaatga cggatggcac cattccataa gcaagcatcc atctccagcc ggtgtgcacg 2897641 ccccattcgt atgttccgga ccgctgcaca gctagattaa taaagtatgt tgcggaaata 2897701 cccagtatcg taaagagctg atataacgaa gataaacttc cgcgtatagc gggcggtgcc 2897761 gcttctgtaa tatacgtaac agagagcgat gagcccatcc cgattcccag ccccccgata 2897821 atccttgcaa tgattaaggt ggacacgtct tgagaaagcg ctgaaacgat tgctgatatc 2897881 gcaaataaca aagcggctgt cattaaaatt tttctccggc cgaatctgtc acttaaaaat 2897941 ccggatatcc cgacgcccac aactcctcca atcataatgc ttgaaatgac aagtccctcc 2898001 ataaacggac tcaggctgta taaatctttc agaaaaccga tggcgccaga aatcactgcc 2898061 gtgtcatagc catacaataa gccgccaagc cccgccgcac atgagatcaa aatgacaaat 2898121 cccattgaat ggcttcttgt tacaggaaca tttggttcta attgagttgg agtattcttc 2898181 atttccctgc cctcccgaat gttgagtaaa gcgttttcat ttaaaccttc aattgtacgt 2898241 acttatatta aaatttaacg aaaattacat ttaattagta cgtacaaata tagaataatc 2898301 ttgtttgcat tttctgtcaa tgttttctta caaagaacgc tgtgatatac tgaaatttgt 2898361 ccgtatacat tttggaggaa tggatatgtt accaaaatac gcgcaagtaa aagaagaaat 2898421 cagttcttgg attaatcaag gcaaaatact gcccgatcaa aaaatcccta ccgaaaacga 2898481 attaatgcag caattcggcg tcagccggca taccatccgc aaagcgatcg gagacctcgt 2898541 atcacaaggt ctgctgtaca gcgtgcaagg cggaggcacc tttgtcgctt cacgctctgc 2898601 taagtcagcg ctgcattcca ataaaacgat cggtgttttg acaacttaca tatcagacta 2898661 tattttcccg agcatcatca gaggaatcga gtcctattta agcgagcagg ggtattctat 2898721 gcttttgaca agcacaaaca acaacccgga caatgaaaga agaggcttag aaaacctgct 2898781 gtcccagcat attgacggac tcatcgtaga accgacaaaa agcgcccttc aaaccccaaa 2898841 catcggctat tatctgaact tggagaaaaa cggcattcct tttgcgatga ttaacgcgtc 2898901 atatgccgag cttgccgcgc caagttttac cttggatgat gtgaaaggcg ggatgatggc 2898961 ggcggagcat ttgctttctc tcggccacac gcatatgatg ggtattttta aagctgatga 2899021 cacacaaggc gtgaaacgga tgaacggatt tatacaggcg caccgggagc gtgagttgtt 2899081 tccttctccg gatatgatcg tgacatttac aacggaagaa aaagaatcaa aacttctgga 2899141 gaaagtaaaa gccacactgg agaaaaacag caagcacatg ccgacagcca ttctttgtta 2899201 taacgatgaa attgcgctga aggtgattga tatgctgagg gagatggatc ttaaagtgcc 2899261 ggaggatatg tctattgtcg ggtacgatga ttcacatttc gcccaaatct cagaagtgaa 2899321 actaacctct gtcaaacatc cgaaatcagt gcttggaaaa gcagccgcca aatatgtcat 2899381 tgactgctta gagcataaaa agccgaagca agaggatgtc atatttgagc ctgagttgat 2899441 cattcgccag tccgcacgaa aactgaatga ataaaaaaag caatgtatgg gtctccccgc 2899501 tacattgctt tttttatagc tgttatctgt ttttccaaac gtcagcgatg atttcaaacg 2899561 aacgcattct gtctgcgtgt tcaaaggttt ctgagttaac cataatttcg tcagcctgtg 2899621 tcgttttgac gaaatcttca agcttcgcct tcacttcttc cggacctccg acaatcgtgg 2899681 agctcagctg ctcattgacc atcgcttttt catacgggct ccagatttgg tccatatcct 2899741 caacaggcgg tttaagctgg ttaggcgtac cgcggacaag atcaagaaac ctttgataat 2899801 gggaagtcgc aaggtgctgc gctttctcgt ttgtatctgc cgcgataatg gtgacaccga 2899861 ccatcgcata cggttcgtcg agcacgtctg acggcgtgaa ggaattgcgg tacagctcca 2899921 aagcgggaac cgtattcgcc ggtgagaaat gggccgcgaa cgcaaacgga agaccaagtt 2899981 cgccagccag acgggcgctg aagccgcttg agcccagcag ccaaatcggc acatctatgc 2900041 cctctccggg aatggcgcga acttgattgc gcacatttcc tgacggttta aaataattgc 2900101 gcagttcctc taattgttct ggaaaatcct ccccgctgtt gatgtttctg cggagcgctc 2900161 tggctgtcaa ttggtctgtt cccggcgcac gtccaagccc cagatcaatc cgcccgggat 2900221 acagtgtttc cagtgtgccg aattgttcag caatgactaa tgaagagtgg ttggggagca 2900281 taatgccgcc ggaaccgacg cggattttct tcgtgcctcc ggcaatatgg ccaatcaaaa 2900341 ctgcggtggc agagcttgca acaccttcta tattatgatg ttcagcaagc cagtaacggt 2900401 gatagcccca ttcctctgcc cggcgcgcca agtccatgct gtttcggaat gattctgcaa 2900461 tcgttcctcc ctgaacaacc ggagataaat tcaagacaga aagcaaggta tctttgcgtt 2900521 ggttgttaga catattgttc tcctttgcaa atgtgttatc agtaaacagc ccaaagctgt 2900581 caggtcatga ttgaaagaac ttctatcaca ccataacaca actgcattca ggaataaaag 2900641 aatttgattc gatgaaattc gaacaatata aaacgaacgg tttggaacat tattctgctc 2900701 caaacaactc cttagccatc tcaataaaga gcttagccgc cagagaagcc tcctttagcg 2900761 acggaacagc aagctgcaca tcacggtata cctgcgggtc caattccctg gtcaccacat 2900821 gctctggcag cggcatcccc gacatggaca tttctgataa aatggccagg cccaggcctt 2900881 ctctgatcat actgatcgag gtgttgatgt tatagaccgt gaaagctggg tgcagcgtag 2900941 cacccgcctg cctgaacata tcgataaatg gtgattcata gccgccgtca cagacgatca 2901001 tcggttcatg gtcaagatct ttcagcgtaa tggctgaatg actggcaagc gggtgatcgt 2901061 ccctgagcac gacagccatt ttgtcttttt tcaaatgaat gtactccatc tcctctgttg 2901121 gatacagaag aatcccaaca tctatcatcc gcgtatgaag ccactccttg acttcattta 2901181 cagttccctc gtgcagcacg agctcaagtt tcggatattt ttgtttaaat tcactgatca 2901241 gcttcggcat aaaataagcc gaggcagttg agaatgtgcc gatatggatc gttcccagtt 2901301 caagcccttt ttccgctgct gctacctgct caactttttc aatgcctttt aagacttctc 2901361 tgatgtgtac taagatctgt tttcccgtat ccgtcagcat caggccattg cggcggtcac 2901421 gaatgatcag ctttacatca agctcagctt cgatcgcaga aatcgcatgg ctgacagccg 2901481 gctgtgtcat gttcagcgcc tgacccgctt ttgtaaagct tcccgtttca gctattttca 2901541 caaaaacctt taattgagta atggtcataa caatttactt atgctcctta taaaaaagat 2901601 tcattttatt tatcttatgt tctaccgtat catatgatgg aaaagttcta caaggagtga 2901661 atgaacaatg aagcagctcc caaaaacgcg gacagctctc ctgctcgcat ttctcgtcat 2901721 catgtggggc gtcaattggc cgctgtccaa agccgcgctc gcctattctc cgccattatt 2901781 gttcgcgggc atccgaacgc tgatcggcgg gcttttatta gtcatagtcg cactgccgcg 2901841 tattcataaa ttacgcttaa aagaaacgtg gccgatttat cttgtttctg ctcttttaaa 2901901 tattacatta ttctacggcc tgcaaacgat cgggctgaat tatcttccgg ccggcctgtt 2901961 ttctgcaatc gtcttcttcc agcctgttct gatgggtgta ttttcttggc tgtggctcgg 2902021 cgaatccatg tttgtaatga aagtgattgg cctcatcctc ggttttgcgg gagtagccgt 2902081 cattagtgct gcgggctttg gcgggcatat ttctgtcatt ggggttctgc tggctctcgg 2902141 ctccgcagtc agctgggcgc tcgggacagt atatatgaaa aaaacaggca gccgcgtcga 2902201 ttccatctgg atggtcgctc tgcagctgac gatcggaagc gtgtttctgc ttatctccgg 2902261 cttttggaca gaaagctttt cggcgatcca atggacagct ccgtttatta cgagcctgct 2902321 gttcatctcc gtattcgtta tcgcactcgg ctggcttgtc ttttttacgc ttgtcggttc 2902381 aggagaagca agcaaggtcg catcttatac ttttttgatt ccgctcatat caatcgtggc 2902441 cagctccatt ttcctgcatg aaccgctcac ccttagcctc ttggcagggc tgctgctgat 2902501 tgtcacgagc atctgtctcg tgaatacaaa atcaaaagcg cagaaagctg cggcgattgg 2902561 tataaacgag aaagctgcac aataataaaa accctcttgc cggatgcggc aagagggttt 2902621 cttatttact gatgcttgcg tcctttgacc aaatatgcaa ctgtaatcaa aaggtagatc 2902681 gccgcagtaa tgccggtaat gacaattgat gttgtcatga tgaccccgat cagaatggcg 2902741 agtaatgcca caatcgcaaa ccatgtcgtg tacgggaacc attttacata ataggccggt 2902801 gtttccgttt gctgttttct cgattttaaa tgagcgaatc cgatgatcag ccaaatgaat 2902861 aaaacggtat atcccaatga tcccattaaa taattaaatg tttggcttcc tgcgaacaga 2902921 gaaatcaata cgccaatata gagagaagaa gtgcacatca gaatcgcaaa catcggtacg 2902981 tttttcgatg aaagcttcga gaagaccttt ggaagccttc cgtcacttgc ctgtgtatac 2903041 aaaatgcgtg atgatccgta taaacctgaa ttcatagaag aaatgatcgc cagcaggatg 2903101 actgcattca tgatatgatc cgcgcccgga atgcctacca ttttaaagac catcacgaaa 2903161 ggactttccg gaacggaatt gacttggttc catggaatca ggctgacgat gatgaaaaac 2903221 ggcagcaggt aaaacgcgac aatccgtgtc agtgtgctgc ggacagcttt cgggacaacc 2903281 ttttccggat tttttgtctc tgcaagcgtt acaccgataa tttctgtacc gccgtaagag 2903341 tagatgacga caagcatcgc cgtgatcagc cctgtgccgc cgtgcgggaa aaatccgccg 2903401 tggtctgtca ggttggaaaa tccggatgct gtatgatcac cgaatgatac aaataagagc 2903461 agcaatccca gaataataaa gataataata acggtaatct tgatcattgc cagccaatat 2903521 tcagtttcgg cgaagatttt aacagaaagc aagtttacaa tcgtgacgat aagagaaatt 2903581 cctaatgcca acacccagat cgggcagccc ggcagccaat attgaatgaa aatcgcagct 2903641 acaacagctt cagccgcaat gttaagcacc cacattttcc agtagatcca gtccaaaaag 2903701 taagcagcgt aatttcccaa tacctgctgg acaagatcac ggaaggttct ggcgttacgg 2903761 tttcgaacag ccatttccgc cagcccctgc ataataaaca gcaaaataat cccgccgagc 2903821 aggtatgcga taatgacaga tggccctgcc acatcgatcg ctgagctgct ccccttaaat 2903881 aaacctgcgc cgattgctcc gcccagcgcc atcatcataa tatggcggga cgtcatcgtg 2903941 cgttttaacg tttgattgtc gtttttcatc ctcttctacc tctccttctc gttttcaaaa 2904001 acaaaaaagc ccgccgtctc ctacctaatc taatagataa agagacgacg agccttcggc 2904061 tgaccgcggt accactcttg ttgattcttc atgaagaatc ctgcttttga cctgtaacga 2904121 aggttagccg ttaaaacata gggaatattc aatctattcc gttccgtctt accactcccg 2904181 ggcgagttca aagaagaatc aggctgcgtc gcaccacccc gcagctctct gttctgatca 2904241 ctttctttta ctgctcccaa tctatgtgtt ttagttttct gaaaaactca aattttatga 2904301 tctgaatata ttaacataat atacgtgctt ctcttttaac tgtcaataac ttcagagaaa 2904361 aaagaaactg ttattttgtc ccttttcgaa tggctttcca aaaggattct gactcgtttc 2904421 ctaatgcgta aactgaaaca cctgctattt tatattgctt tgccagatgg cttttcgttt 2904481 gaacggtttt ttcgttttca taccacacga catgtttatg cttctttttg tcaacataag 2904541 aaaacgtcat cgagcctgat tttttgttga atgccggctt tgctttttgt tttttgatga 2904601 gggatttgag ctcattccat tcccttattg tgctggtact tccgtctttt acatcccagt 2904661 catagccgta cgcagggatt cccatgatga ctttattggc tttgatcttt ttgactgaaa 2904721 actgcagaga gcttttgatc cagtttgtgc ttgccactga ccccggctca ccccaaatgc 2904781 cgtgttcatc gtaggtcatg acttgtacga agtcggcata tttgccgatt ttcgcataat 2904841 catacggcca gctccagtca tcatttttat catcggcgct tttggccgga acggatacca 2904901 ttgttttaat atgtttctta ttcaaagcct gtgagacata ttgaatgaag ttcgagtatg 2904961 cagcgcggtc ttctggattt actgcttcaa aatcgatatt gattccgtaa tatgagtgct 2905021 ttttggccag tgtaattaac tgatctgtga atcgtttttt cgctgtttta ttgctcatga 2905081 cccgactcgc taaatctccg tcaaaatcat aaatggcatc attatagttt gaaatgacag 2905141 cccatgtctt gatttttttc tttttcgcat atgtcagctg cttagttggg gcatcgccaa 2905201 tgatttgtcc gtttttttca aacgcaaatg tatcggttgc gatggcattc atgtatgtat 2905261 gatatttcgt aagagaattg tatgaagccg tatccccagt cgtgtagcct actgtcatac 2905321 cggctgcctt cgcttctcct tttgtataca taaacagaac aatcgcaatc gccagtgaaa 2905381 ccgctatgat cagccatttt ttcatcgcat ttcctcctgt atcaagtcat actcttctca 2905441 tcggccaaaa aattggaagt tgaagttttt tcaagcaaaa agcccggcat atgcctgccg 2905501 ggcttcctga gttcagcggt cagagacgag aatatatgct gcctttactg gtccatgcac 2905561 ccccacaact aaatccattt caatgtcggc tgagttactc ggtccggtaa tgtagttgat 2905621 acatgaagga acagtgacac cgttcgcaat gttttggcgg atgatatcac tggcttgtgt 2905681 cattctcggt acaatgcttg atttcggcac gatcgcaata taagtcgttg gcaaaaggct 2905741 gacagagcgg ccgatgtctt ttgaggagaa gaggacaacc gtccccgact cagccaatgt 2905801 aatttcgctg aatgtaatcc ctacattggc ttgctccgct tttttaatat tttcctcgcc 2905861 tttgtcagca tcccactccc agaccggcgt tccttcactc ggccagtcct tggtgagcag 2905921 gcttttcagt ccgtattctt caaagcgggg gtccttcgga atgatgacag ggcctccaga 2905981 aaagcggctg acttgctcgc gcagggcatc gtaaaggccg gttgaatccg tttcaatcag 2906041 ctctgtatgg attttgacac aatggttttt gagcactgtg actaagtcat ccgctgaata 2906101 accttcaagt gttttatatt gcggctgatg cgcccattca gggactgcca cgcctcctgt 2906161 tcttcgttca cggcccaggc tggatgcgat tcggtttaaa aagctctctt gattctgaat 2906221 ggttcccttc gtcatcactg ctcctccttc gtgcgttcac ttgtttctct gtccgcaaac 2906281 cagtctctga atctcgattt atgcggtgcc gggaagtcgc gaatctgggt ccaattttta 2906341 agcgggccgg gccctttcga aattttttcg tcctctgtaa aaggcgtcat ggcggccggc 2906401 gcccattttg agcccatttt gtaaagcgat aaggaggatg cgccaagtcc gaatgctttc 2906461 attgcaagct tttcactgat cggcgccctg ccttcttttt cgacgatatt ctgacgatgc 2906521 ttgagtagca gctcatgaag cgggattttg accgggcagg cttctgaaca agcagcgcac 2906581 agtgaagatg cgtacggcag ctccttataa tcgtcataac cgccgagcaa cggtgataaa 2906641 acagctccga tcggccccga gtagattgag ccgtatgaat gtccgccgac atggcggtac 2906701 acaggacaga cattgataca ggcggcacag cggatacatt gcagcacaga ctggaattcc 2906761 gttccaagga tattggatcg tccattatca acgatgacaa gatggaattc ttccggaccg 2906821 tccacttcac cttccagctt cggacccgtc aaagctgtaa tatagcttgt cagccgctgt 2906881 ccgacagcac ttctagtcag catgctgact agcacttcaa attcagaaaa tgacgggaca 2906941 atccgctcca ttcccatgac ggtaatttgt gttttcggca aggtgctcac aagccgtcca 2907001 tttccttcat tggtcacaag gctgacggaa cccgtgtcag cgatggcgaa gttacagccg 2907061 gtaatgccga tatccgcttc cagaaacttt ttccggagaa tggcgcgcgc atgcatcacc 2907121 agctcttccg gtttttctgt atgttgatag tccagtcttt ctttaaacac atcgcgtatc 2907181 tgctctttat ttttatgaag agcgggcgct acgatatgtg acggcggatc gtgatcatca 2907241 atctgcaaaa tatactcgcc gagatcggtt tctacgactt cacagccttc cttctccagc 2907301 acctcattca gattgatttc ctctgtgacc attgatttag atttcacaat tttcttcccg 2907361 ttcttctttt gaatgacatc ccgaatatag gaagacgcct cttccgctgt tttcgcgaaa 2907421 tagacatgtc cgcctctttt cgccacattt tcggcaagct gtccgagata gaaatcaagg 2907481 ttttcaagga catgctgcct gatttcctct gataatgagc gccactcctc ccagtttccc 2907541 agttcttctg ctgcctctag gcgccgcgtc cgcagacgct cctgtgcacc tgaaacagcg 2907601 cctctcataa attcattatc aatcccctgt gatacccgct ctttaaaagc gtcagtaccg 2907661 attttcatcg ccatgatcct ttccccctct gaatccagtt ttatctgctg ttgagcactt 2907721 cggcgatgtg catcactttg acattcttat cttttcggcc aagccgtccc ccgatattca 2907781 tcaaacagcc gcagtcagca ccgatcagca cctctgctcc cgtttcctcc acacattcga 2907841 ctttttcatc gaccatctgc tcagaaatct gcgccatctt gactgagaac gttcctccga 2907901 atccgcagca gttatgtttg cccggaagct ctgtaaactg caggcccttc acatggctca 2907961 acagcttcat cggctccttc cgaacaccca gcagcctagt catatggcac gacgtatgta 2908021 aggtcgcttt tgtatgaagg gtcgcgccga catcctctac cccaaggacg ttcacaataa 2908081 aatctgtcag ttcatacgtt ttatccgcca gctttttcgc tttatcggcc catttcggat 2908141 catcctgaaa caggtgcgga tactcccgga acatcgttgt gcaggaaccc gaaggactga 2908201 caacatattc ggaatcctga aacgtttcga tcatccgttt cattgctttt ttggcgtcat 2908261 gtacatagcc gctgttgtaa gccggctgtc cgcagcaaat ctgcccttct ggaaaatcaa 2908321 cctcgcaccc aagccgctcc agcagctcaa ccgttgcttt tccgacattt gtttgaaaca 2908381 tatcaacaag acaagtgaca aaaagtgaga ctttcatgat gaacccctct ctcatcccca 2908441 atatatgatc aggtcatctg atgacctgag ttaaaataac tatatgaata tcgtacacta 2908501 ttctgacaat ggaaggaaag agttttctag ggatattttc atttgtggca tatcaaaaac 2908561 actcccgatc tcccaggagt gcagtatatg gttagatcca gcccttttcc tcagcgatgc 2908621 tggcggcttc tgtccgattt ttcgcattaa gcttttggat gatttctgag atatagtttc 2908681 gaactgtgcc ttgagataaa tagagctcca gcgtaatgtc ttttgttgtc ttgcctaaag 2908741 ccgcaagcct cagaatttct tgctctctaa cggttagcgg attttcgtct cgcatcatat 2908801 taaacgtcag ctcagggctg aagacacgtt ttccctttac acattttcga atggcatcgg 2908861 ccagatcgtc aatttcaccg tctttcagca gatagccatg tgcaccggcc tttacggcgc 2908921 gttcaaaata tccggggcgg gcaaaggtgg ttaaaataat gaccttgctg acgcagcctt 2908981 ttttcattaa ttcctctgcc acattcagcc cgcttcgaac cggcatttca atgtccataa 2909041 tgcatacatc cggctccagc ttcaaaatag catgtagcgc ctcttccccg tttaatgctt 2909101 gtccgatgac tgtcatatcc tcttctaaat caagcaaaga tcccaaagcg cctaaaagca 2909161 ttcgctggtc ctcagcaata aacagacgaa tcattctttt cgtcctccaa tcattctgct 2909221 tttttaataa gcggaatcgt cagtgccaca accgttccgt tatggtctga aaccgttaat 2909281 cccccttcaa tgagcatgag ccgttcttcc attccccaca ggccattccc aaacattttc 2909341 tccttcggcg ctccctttcc gtcatcccgt attacgatcc tcattttgtc agcaaattga 2909401 gaaatggtga tggcacagtg ggttgctttg ctgtgcttga taatgttagt cacggcttcc 2909461 cgcatacaca tactgataat attttgagtg acgggagata tcactgaaaa gtcgtcggct 2909521 ccttcgtatt gaaaggtaat gttccccgct cttaatatgt gctgaatgtt tacgagctcc 2909581 tctgttatcg tgaccgttct catatcagaa accagctctc gaacttgctt gagtgcggag 2909641 cgtgaactgg tttccatttc ttttgcctca agcttggtcc gttctggatc agatgcagcc 2909701 agccgctgaa tgagctggct ttttaatgta agcagcgaca gggtgtggcc aagagtatcg 2909761 tgaagatcac gggcgattcg aacacgttcc tcccttttag agagttcttt tatctgttcg 2909821 ttggcttgtg caagcttagc ttcaagctca atcctccgaa acatagaacg aattccgaat 2909881 ggagaaatga gcataatgac gagaaacggg agaacagaaa aaagctcccg aagcgagacc 2909941 gaattcgcga taaattggta taggcatgga aaaagcagta taaagattaa agcgcagaac 2910001 gcacggttaa aattcgtttt ctctttgtaa taaccaacaa agtttgccgg aaaaaaacct 2910061 aagtatatat aggtgatatt gtaaaacaca ctatacatca aaataaccgc catttgcacg 2910121 ataagccaat atgtaaacga agctttgccc acgctgcaga ataactggcg atatgccgct 2910181 acaaaaagga gcagcatacc atatccgatc ccctgtttga cccctgattc ttttaataaa 2910241 gagaggaacg gcataatcgt atacaccaga aagatataag ggaaaaaccc gaattccttc 2910301 gggaaaatag atattgcctt tttcatgtat tacaccgctt cttgttttct tcttatatat 2910361 ttagatagta gcatgaagag catcatataa gcgattaata tcagaatatt tttccaagtc 2910421 ggactcccac cccggacaag ttcccacgct ccgctcccga aatgataaga cggaagccac 2910481 tggccaatgc tctgcatcat gtcaggcatg acctcaaacg gcatccacat ccctccgcct 2910541 aaagccagca gcatataaag cacattactg attccggccg ctgtttctac ttttctcatg 2910601 aggccgatta gtgtgcctaa tgctaaaaaa ggcaatgcgc caaacaaaat ccacagtccg 2910661 ctcatcatcc attcaaacgg tgacaaggca atatcattga tgattgcgcc gaacagaaat 2910721 atgacggtaa ttgataaaac gtgaatgaca ctttggccga tcatctgagc tgataaatag 2910781 atatgatccg gaagaggcgt aaggcggata aaggcggccc agccttgtga ccgttcttgt 2910841 accattcgga tgccaagcgt catgatagag gaacccatca cgctgaagac tgtcatcgac 2910901 atcaggtaat gggcttccca tgcacgttga tcagggacgt tggtattcac tacatttgta 2910961 aagaaataat aaaaggcaat cggcatgatc agagaccaaa gcacaaagta cttgttccta 2911021 agcacccttt tcatttcagc gatgctttgc ttttgcagca cgttcactca catcgcctcc 2911081 ctgttgccgt cagccagctg gcgaaatgcc tcatcgagcg ttgcttgctc aattcgaata 2911141 tcccgtgcat gtatgttttc ttgaaagatc agcgccaaca ctttgtctgt atttgatgtc 2911201 tggatgatgg ttctctcatg ctcgtggatc actctctcga cttccgggtg acaagacagc 2911261 ctttccaatg attcacttga atgaagcgta aaggaaacag actgtttttg aattcttgag 2911321 cggatttgca ttggtgagcc gtctgcaaca agctgtcctt cagtaaaaaa taggattcgc 2911381 tgtgcggcat catctgcttc ctgtaaataa tgagttgaaa aaataatcgt ttttccttgg 2911441 tccgacagtc cgtgaatggt ctgccagaat cggtgtcttg atgaagtgtc catgccgact 2911501 gtcggttcat caagtataag cagctccggg ttcccggcaa gagccaaagc aaagctcaaa 2911561 cggcgttttt gtccgccgga taatttttct gctcttgttt tcaaatcttc tttggtgagt 2911621 gctgttaacg aaacgagttc tttcatggac aatggattcg gataatagct ccggaagagt 2911681 tcaaggattt catccacctt aaggcccggc atgacactta cttcctgaag cattacacct 2911741 attttttcac gaacctgttg atcatcggga acccggttaa atagtttgat ttctccctca 2911801 ctcggtttca gcaatcctaa tatcatcgag acgacggtcg tcttccctgc cccatttggc 2911861 ccgagaatgg ctgcaatttc tcctttttca atactgaagc tgatgttgtt tacagcggtt 2911921 tttcgctgga aatgttttgt cacgttgctt actgttactg cttctttcat cacatgagca 2911981 cctcctgatc gtttacattg attgtaaaat gacggagaag acgatgttag tatggggtgt 2912041 catgatgatg gagtgacaaa tgtcattttt ttctcacccc ggtgtctagg caatcctcct 2912101 cctgcatctt ccaattcatc catcttttct atctcccatg tcctctttct tttaaactgc 2912161 tgtgacattc atagaaagat acactcttca aaccatccga gtgttatgat agaaatattg 2912221 aactttatat tactttccgg ctgaaaggag ccaatcatga acgaagcgat tttgtctaga 2912281 aatcatgtga aggtgaaagg cagcggcaaa gcatctatca tgttcgcacc tggttttgga 2912341 tgcgatcaaa gcgtgtggaa tgccgtggca cctgcctttg aagaagatca tcgggtgatt 2912401 ttatttgatt acgtcggttc gggacattca gatttgcgcg catatgacct gaatcgttac 2912461 cagacacttg acggctatgc ccaggatgtt cttgatgttt gtgaagcttt agatctgaag 2912521 gaaaccgtgt ttgtgggtca ctccgtcggg gccttgattg ggatgcttgc atccatccgc 2912581 cgcccggagc ttttttccca tctggtgatg gtggggcctt ctccttgcta tttgaatgat 2912641 ccgcctgagt attacggagg atttgaagag gagcagctcc ttggcttgct ggagatgatg 2912701 gagaaaaatt atatcggctg ggcgactgta tttgcggcaa ccgttctgaa tcagccagat 2912761 cggcctgaaa ttaaggaaga gcttgaaagc cgtttttgtt ctactgatcc tgtcattgcc 2912821 cgccaattcg cgaaagcggc gtttttttct gatcaccgag aggatctttc gaaggtaacg 2912881 gttccctctc ttattctcca atgtgcagat gatatcatcg cacctgcaac agtaggtaag 2912941 tatatgcatc agcatctgcc ttatagcagt ctgaaacaaa tggaggctcg cggacattgc 2913001 cctcatatga gccatccaga tgagacgata cagctgatcg gcgattattt aaaagcacac 2913061 gtgtgatata ggaacgaaag ggatagaggt gaccctctta gatggacaaa caattgaatg 2913121 atgcaccatg cggtttcctc gctttgtcag aagaggggtc gatcatagct gccaaccgca 2913181 cccttatcaa gattctggat tatgaaccgg agcaggttat cggccagcac atgaatatga 2913241 tgttgaccat tcccgcgcag cttttctgcc agctttattt ttttccgctt ttgaaattgg 2913301 agcatcacat cgaagaaata tacatttccc tgaaagcaag agatggagaa gaaattcccg 2913361 tccttatcaa tgctattgcg agacacgata gcggggcttc tgtctttgat tgtgttctga 2913421 ttccaatgcg aaagcgaaat gaatatgaaa atgagctgct gatagccaga aatgaggctc 2913481 aggaagcttt gcttgccaaa cagaaagcca atgcggagtt agaaattgcc ttggaaacgc 2913541 tgaaagcaaa acaagaagaa cttcttgaga tcaataaaca aaatcaacaa tttaaattaa 2913601 acaccaaaag agagcttgaa ctcgccagaa agatccagaa aaactcgttg actgaaccga 2913661 ttgtaaacga tcaggttcag attgactctt attacaacgc atcgagtgaa ttgtcaggtg 2913721 atctttacgg atattatcaa atcgatgaac accgttacgg cattattatc cttgatgtga 2913781 tggggcacgg aatttcatct gcattgatta cgatgtctct tcatcctttg ttccagcgcc 2913841 agatcacgca aggtctcagc cccgttaaag ttatgaagga attggaccgg caccttcaca 2913901 gcttgtttca aaatgatgag gaagcaagac attattgcac tgctatttat ctcgagattg 2913961 atatagcacg gcaaagaatt gattatgtca acgcagggca tccgccggca ctttggcagg 2914021 acgatagcgg aactcaacat ctgcttcacg cgacctcgcc tccgatcggg atgtttgaag 2914081 acttagagtt tcagtcaagc agcctttcat acacggagga cggaagattg cttctgtata 2914141 cggatggcgt gatggatcct acggcttcat gttatttatt tgatttacta aaggatcatc 2914201 ctgattcgcc aatcgctgac ctgaaggaga aaatccttac atcactgcag catcaaaagg 2914261 aagctcatca taagagtgat gacgaatgtt ttatattagt tgatgtaaaa taaaatgatc 2914321 catgagacat aacaatgatt tgttacatct catggatttt tttgtttcag cgtttctttg 2914381 gaatatgtcc tgactccgca tattgaaaca cctgcaagga aggcagcggg tgtccattaa 2914441 aatcaaataa agcttgatta tctacagcac ttcccccata ccacttcccg gcgtcttcag 2914501 ggtcgtattc agcagcatag ctggacgccc accctgaccc gtatgtttcc cataacactt 2914561 tgtttttctc tatctgtgtc ttcggcccga ctggaatcca cgccggctcc cagtagaaaa 2914621 caccaagtcc tgctttgccc gtattcgcca ctgcctccat tacatctctt actgcagttg 2914681 cctggccttg aacagaaatt ggatatggca acgtctgccc gctttttggt gctgtatttc 2914741 catgcccatc gccatcctca gcggtatagg tgtacgatgt ctccgccacc atgacttttt 2914801 tgccgtacgt attggcaaca gccttcagca cggaggtcaa attttgtaat gtgccatgcc 2914861 agaaaggata ataggagcta gcaaacacat cataatccac tttgtttttg ctgagtgttt 2914921 ctgcaataaa tgaatacctt ccagccgttt caggattggt aaaatgcagg gcgaccaaaa 2914981 tatttgaatt tgtctccctg accgctcggc ttccttcatt aaataattgg cacatcttcg 2915041 tccaatcagt ctcaccggca aatcctcctg ttgtttcatt tccgacctga accatgccga 2915101 tgtcaacgcc ttccttgatc atcttttgca ggctttgttt cgtatactca tagagctttg 2915161 ctttttttgc ttcaaagctg agattcgccc aggctttggg caccttttgt ttcgctggat 2915221 cggcccagaa atcagagtag tgaaagtcgg ccagcacctt cattccgttc gctgtcgctc 2915281 tttttccgat ttcgatggct ttttgaacat cattgtttcc cccgccatac ccgttgccat 2915341 ttgaatcata cgggtgattc cagatgcgga cgcgaacata gttgacccca gcctgtttta 2915401 aagttgtaaa gatatcctgg cgttttccgt ttgtattgta aaaggtgaca ccgctgtttt 2915461 ccaaagcaat aacgctggat acatctgccc ctttgataaa atccttgttc atcccctcta 2915521 cttttttaac aaaaagatcc tctgcccgaa gctctgacac gtgcttctcc ttctcaatgg 2915581 cagcggcata tcctgttgaa ctacatgcac tccacacgat ggcagccgca aagaacattt 2915641 tcactttgct tttcatgatt tcatcccccc aagacttagc aagcgttttc attctataga 2915701 aaaaagaatc cgcccatatc gagcggagca tcagcctaat gtgtgtttac gacaattctc 2915761 acttcatact tttccatcgt caggtcgcct gacaatatgt ctcctgtcat tatgtccttc 2915821 acactctgat caaacgtgac cagctgtttt tcttccgtga aattcatgac aaaaatataa 2915881 tcattgtcct gatcctgcct cgcttgtacg gagacgcctt ttccgtgccg aaccggaaaa 2915941 actggagaga gagacaggtc tgtgatcaga ccctcataga aatcacgctg aaattgatcc 2916001 tccaaacgcg cgccgataaa atacgccttg ccctgctgat actcatggct tgtgaccgct 2916061 ggcgtgcgcg cataaaaatc ttcttgatac accgcttcca ctgaagctgt ctttacatca 2916121 atcacggttg cataatcctt catttcatat atttggctgc ggtagctgac agcgtttcga 2916181 tccttcggat acagggtgtc cgtttcaaga ggctcaactc caaatatagc ttgaagatcc 2916241 ggatgccatc cgcctgtgta tgttaagtca tgctcattca caaccccgct gatatacgtc 2916301 atgactaagg tgccgccgtc agccgtaaac gcttttaaac gggaaacggt gtcctcgctg 2916361 attaaataca gcatcgggac gatcagcagt ttatatggtg aaaagtcttg ttctttcgtg 2916421 atgacgtcga cagggatatc gtgttcccag aatgtgcggt aatgctgctg aagcgtttgc 2916481 ggataacgtt ttgtcgcctt cgcaaacccc tgagcatcct cgagcgccca atgattttcc 2916541 cagtcatata aaatcgcggt ttgagccggc ctcttcgttc cgacaacttc ggacagccgt 2916601 tccaatgtct cgcctacctt ggccacttct tgaaagacgc ggttcttcgg gctattgtca 2916661 tgatccacaa ccgctccgtg taatttttct gatgaccccc gtgatttgcg gtattggaaa 2916721 tagagaacgc tgtccgagcc gtgggcaatc atttgcatgg atgacagcag attcatgccc 2916781 gggcgctttg ccttgttgac gttatgccaa ttgaccgcgc ttggcgtaca ctccattaat 2916841 aagaagggct gctgcttcaa gcttcggtac agatcattga taaagccgac cttcatcgcc 2916901 aaatcagctg tgctttccca gtcattgtgc cagacaggat aagcgtccca gctgatggca 2916961 tcgacatgct ttgcaaattt gctgtagtcg aggccctgat acgggatcaa atccggtgtg 2917021 tcagccataa aattcgttgt gatagggata tcaggcgtca attctttcag cggaatgatt 2917081 tcattttcat aaaacgaaat cgtttgatcg gtgacgaacc ggcgccaatc taaattcagg 2917141 ccatgcaagc cattttcacc gatcggcgaa gggctttcaa tttgtgacca gtcattgaac 2917201 gtatggctcc aaaaaggggt ccaccacgca tggttcaatg tcttgaggct gttgtcatat 2917261 ttcgatttca gccactcccg gaaagcatgc tggcataaat cacagtggca atctcccccg 2917321 tattcgtttg aaatgtgcca cattaacagc gccgggtgat gtccgtatcg ttctgctaat 2917381 aagcggttga tgtgccgtgt tttttctcgg tagactttag atgtgaggca gtggttgtgc 2917441 cttccgccgt gcagctgttt gacgcgggag gcattgacgc gcaaaacttc cggataggtt 2917501 tgcgacagcc aggccggacg ggctccgctc ggcgttgcta atatgacccg gccgcctata 2917561 ctgtgaatcc gctcaaaaat atcatccagc cattcaaatt gatatacgcc ctcctccggc 2917621 tcaagtgcgc tccatgcaaa aatgccgaca gaaaacgtat tcgtatgaga aagcttcatc 2917681 agtttgatat cgtcagctaa aatatcgggc cgatccagcc actgatcggg gttgtagtct 2917741 cccccatgga gcataaattt tgcttttgtt acgtgcgttt tttcaagctt tgacatcaca 2917801 ttctcctcct tgttctctta gcccttcgtt ccgcctgcgg ttaatccgga cacaaaattc 2917861 ttttgcagca taataaagat gacggcaacc ggtatgctga taagcagggc tccggccgca 2917921 aatgtcgtat agctggcccc catgacatca ttcactaaat tgaatagacc gacgggcaat 2917981 gtatatgatt caggcgttct caatatggtt gaggacagca caaaatctcc gagcggaccg 2918041 gtaaagccgt tcatggccac gactgccgcc atcggttttg ataatggcag aatgatctgg 2918101 aagaagattc tggtgctgct ggctccgtca atcttggcgc tttcgtctaa atccatcgga 2918161 atggaatcca tgtacccttt catcaaatac gtattcatcg ggatcaggcc gccgatataa 2918221 agcaagatta gcagccagtg gctattgatc attcccaaga tttgcgccag cacaaacaag 2918281 gcaattaaag ctgaaaactg aggaatcatc tgcagcaata aaaagagcgt taaagcgtat 2918341 ttcctccctt taaaccgaaa gcgcgaaaac gcataggccg taaacgtcac acagagcaaa 2918401 gaccctgcca ttgtaaacag gctgatcttc atagagttga cataccactg cacatattga 2918461 aggctttcct tgcccgcaaa taattccttg taatgatcga atgtcggatg cttcggaatg 2918521 atggatgtac tgattaagct gttgccggga ttaaagcttg cgcctgccgt ccaaaggaga 2918581 ggataaacaa tgatgaccgc cataaaggct agcaacaagt aagagaaaag gagacggata 2918641 tatcttctga ctttcatatc tgccagcata ccttatgcct cctctttaaa agactttgtc 2918701 tgtctgaact gccacaatgc gatggagata acaaatacag ataataaaat ggttaaagcc 2918761 gcagcaagtg aatattggct ggactgcatt gtcaatttat aaatccatga aacgaggata 2918821 tctgtcccgc cggctgttga tccggttaca gccggacctc cgccattgaa tagatagata 2918881 atattaaagt tattaaagtt aaacgtaaac tgagtaatga taatcggagc cattgcaatg 2918941 aacaccatcg gaagcgtgat gtatctcagc tttgaaaaga cagaagcgcc atcaatcgta 2919001 gctgcttcat acagatcgtc cgggatggat tgcaatacgc ctgttgagac gagaaagatg 2919061 tacggaaatc cgagccagcc ctgcatgaga atcaatgcaa gcctcgacca attggcatct 2919121 gtcatccacg gaagcggatc tatcccgaag aaagccaaga tgtcgtgatt catcgcaccg 2919181 aagctatcat taaacagtcc cgcaaaaatt aaaatcgtca caaaaccggg aacggcccat 2919241 ggcaaaatca gaatcgtccg aaaaaaacgt ttaaaccgaa ggtctttctg gttaacaatg 2919301 atcgcgagaa aaatccccaa ggtgacttgc agtgtggatg cagcaagtgt ccaaaccacc 2919361 gtccaagcca gtacatcaaa aaaagtcgac ctccaaatat caactgtgaa aatatttgcg 2919421 aacgtttgaa aaccgaccca atcaattaat tttgcaggag gagaatgata caaatcatag 2919481 tttgtaaacg ctaatgcaaa gctgaataag ataggaaaga tcacggcgaa aattaaaata 2919541 aacaaagatg ggccgctgac gacataagga tagccctcag aaatgatatg ctggtattgt 2919601 tcctttaagg aacttaatgg cttattttca tcacgctgtt ttccgctttg gaacgcatcg 2919661 cgaagattta cataatacac cgcaaggcca aagcaggtca cgatgacagc aataatccct 2919721 tccgccagca gaaaaacgga attatcccgc ggcacttctg ttcccagtgt aaagattccc 2919781 caaaacccca tattgagcag atctccaaag accgcaaaaa acgatgcgcc taagaaaaga 2919841 aagacaatac cttttatcca ttgcttgtta taaaattgcc cgagtcccgg aatgatagaa 2919901 agcaacaaag cgacttgacg atgctgcacc gttttcacct ctcttacaat acaaatctag 2919961 ctttctcttt attttccgct gtgctttgcc ttaatttgtc ctttggccgt ttcagctgct 2920021 tgatccaatg cttgtttcgg atctgccttc cctgttgcaa ccgtctgtaa tgctgaatca 2920081 gccggcgtcc atatttcatt catttccgga atatttggtg ttggctctga gaaacgggat 2920141 tgttcagtaa cagcccgtgc cgcctcgctt ttcataatag ccgggtcatt ggctagggat 2920201 ttcacagcag gaacttcttt cgtttcttca tatcgtgttt tagaattttt ttcatttgcc 2920261 aggaaaacgg ctaattcttg cgccagctct tcattctttg aaaatgcact gacgttgtag 2920321 cttttgacgc cgataaagga gctcatgttt ttcccatttt ccagcttcgg cagtttcgta 2920381 atgccataat tgattcctgc attcgaaaag gcttctacat tccatggacc agaaataatt 2920441 gcggcggctt ttccttctgt gaacagcgat tccaacacgt taatcccttg ttctccaata 2920501 atgccagccg ggaacaggcc atctttgtaa aacttctgaa tcagcgccgc acctttgaca 2920561 gctccttcat tattgattcc aatgtctgac gggttatagc tcccatcttt ggcctttcca 2920621 aaaatgtatc cgccatatcc gctcatcaca ctttctgcat aataaatttg atcgaatagg 2920681 gctaaaaagc caaatttgct gccgtcagca gtctttttgg aatagtcgta ccactcttcc 2920741 agcgttttgg gcaattcctt ttctgtgatg agatctttgt tgtaaaaaag cacagtcgtt 2920801 tcgaccgctt ttggcagtcc ataaagcttt tgatctacca tttgagactg aatggaagcg 2920861 tcagtataaa gtgattgaac gtcttttttg acatgtaatt ccttgagtaa tccttccgtg 2920921 acagcggttc cgatttggtc ccctggcatt gttaacacgt cagggcctgt gccggccggt 2920981 ccatccattc gcaaatcttc aatctgcttg gcatacggtt tttcaacgac tttgaccttc 2921041 acatcatgct ctttttcaaa tgcagccaca gcgtctttaa tgccgttgct cttttcttta 2921101 tcctcccata caacaagctc tgaccctttt gaactcgatt tggcgctgct gctttccttt 2921161 gggccgcaag ccgccaagga taaactgaca gctgcgcaga gcatgaatac ggaacacttt 2921221 tttgccattt tcattgattg tcaccctttc ggtaggaatg aaagcgcttt aaagataata 2921281 tagcatgcct gagaaaatgt gtaaacaaac tatttacttc atagagtaaa tttttttacc 2921341 taaataaaaa atgacttagt gtcctaagtc atccttaatt catactcttc ctgacgatta 2921401 attctgcgcc cacatataat gtttttaccg ttcttctctt gtcctgcact tgttcaagca 2921461 gtaattgaac agcgttttta cataattcat gtatatcaat atgaaacgtc gtcagaggag 2921521 gcgagacata cttcgcgaag ctgatgttgt tgatactcac aatgcttacc ctgtttggta 2921581 tggcaattcc tttttcgttc agggcttgca gacagcccac tgcaatcggg tccgctgcaa 2921641 tcataaaagc agtcggaagc tgatcgccta atgtgtcgat cgctgctgac atcaggcggt 2921701 agccgttttc tacagagaat ccgcgatgac agaaaatata gcgctcgtcc agcatggctt 2921761 tttccctcat ataggatctg aaggtttgtt cacggatgtc catttcatcc tgattggtat 2921821 tcggattttt gtatgtgccg ccgataaaac cgatgctctt atgccccttc tcagtcagga 2921881 tgtttaccgt cttccttgtc atttgtgcca aatcgggcct taccgagtca aaatgatcgg 2921941 gatcaggagt tgaatcgatg aacacgccgt tttcagtgag atttctgagg aaagccagct 2922001 cttcatctga aaatgtgccg acggcaataa acccttccgt atgttcagga atgctctcga 2922061 ttccatccgc tattttataa gtggtcatat cgacattgaa tgctttcgcc agtttctcta 2922121 cttctaatct catcgtttta aaatagacat cttctaattc ttctttatct gtcagccaat 2922181 ataaaaacgc aatatgtttc accagcggcc ttactgtttt tttgcggtaa ttgagctttt 2922241 ccgccgcttc atagattttc tcccgtgtct catcaggaac agaaaggctt tcatcgttat 2922301 ttaaaacgcg ggaaacggtt gagattgaaa atcccgcttc ctgcgcgata tctttaattg 2922361 tcgccattgt atctgcctcc attattcagc tcgcattgtt ttagtaaaat attttacttt 2922421 ctttttcaca aatgtcaagt gcacaaagcc ctctggctgc catgtaaaaa gactgaacca 2922481 tttgcggctc agtctcagtt gttcgtatca ttcggaaccg gcggaattgc ccgggaaatg 2922541 agttggttat tgcacatttt cctcgaaata tcccgaaagc acatcttcca cattcgtcaa 2922601 atgcgccagc atggcggctt ccgcctgtgc accgttcccg gcagccacag cattgtaaat 2922661 ccgttcgtgc tcctcataca gccgctgaac ggaggtcttc ttggaaaaca gccagatttt 2922721 cctcgtttcc ctcattgttt ccagcagcaa tgatgacacg tgattcatca agtgtttaag 2922781 aagttcattt tgagaagcgt ccgcaagcgc aagatgaaat gcaaagtctg ctttctctcc 2922841 cagctccccg tccgcttcaa tgctgcccat ttcctttagt gcatcctgaa ttctttcgag 2922901 atctgcttct gtcctttttt cagccgctag tgaagccacg ccgatttcaa gcagttttct 2922961 gacctcgagc agctgcttga cgtcctcttt tttcatcaga agggcggctg agagcggctg 2923021 agaaatttga ttgagctcaa attccttcag atacgtgcct tctccctgtt tcatttcgac 2923081 aagccccatc gcttttagcg cagaaagtgc ttcgcgaacc gctgaacggc tgacttgaaa 2923141 gctctcagca agcgcctgaa cagagtccag tttatccccc ggcttcaatt cgccattttt 2923201 gatcatatct aatagggcat ccgctacttc ttcatatatt tttttgtttt aatctgttta 2923261 tatttcaatg caattcaccc cgtaacttgt aggtctggct gtttacgatc tattatactc 2923321 tgttttgtgg gccgccaaaa gattttgact attttgtcaa aaagtcttgt actttgattt 2923381 ttttcaaaat ataatgctag gtaactggtc ttattaccca gtcatcagat gatcatatca 2923441 tctatagaaa ccgcttacat atggcgccag tttatgtttc aaggaggggt ttgggatgca 2923501 atggacacag gcatatacgc ctataggggg aaatttgcta ttatcagcgc ttgccgcact 2923561 tgtaccgatt attttctttt tttgggcact cgcgattaaa cggatgaagg ggtatacagc 2923621 aggcttggcc acattgggga tcgcccttat cattgctgta ttggtttatc gtatgccggc 2923681 ggaaaaagcg ctgatgtccg cgacacaagg agccgtatac ggattgttgc cgatcggctg 2923741 gatcattgtg acgtctgttt ttttgtataa aatcactgtg aaaacgggac agtttgatat 2923801 cattcgcagc tctgttctct cgattactga tgaccgacgg cttcaagctc tcttgatcgc 2923861 tttttcattc ggggcttttt tagaaggggc agcaggcttc ggagcgccgg tcgccatttc 2923921 tgccgcgctg ctggtcggtc tcggctttaa tcctctttat gctgcgggga tctgtttgat 2923981 cgccaatacg gcgccggttg cctttggggc aattgggatt ccaattacag ccgtagaagg 2924041 gccgacaggg attccggcga tggagatttc gcaaatggtt gggcggcagc tgccgttttt 2924101 atccgtattt attcctcttt atttaatcat catcatgagc gggttcagga aagccttgga 2924161 gatctggccg gcgattctcg tatccggtgt ttcctttgct gttgttcaat atctcagttc 2924221 caatttttta gggcctgagc tgcccgatgt tttgtcagct cttgtttcaa tggctgcgct 2924281 tgctgtgttt ttgaaatggt ggaagccgaa aacaacattc cggtttgccg gtgaacaaga 2924341 gtcggccgcc tcaattgaaa cggcgcgcac aaatccggcg gcgcctgcat acagaggcgg 2924401 acagattttt aaggcttggt cgccatttct gctgctgacg gcgatgattt ccgtatgggg 2924461 cattccatct gtcaaatccg cgctgaccgg gcattatgaa ggctctgcgg tgttcttgaa 2924521 gtggctgaat gctgttggag aaaaactgac tttttccccc ggtgtgcctt ttttgaacaa 2924581 tcagattgtc aatgctgacg gtacgccgat tgaagcggtt tacaagttgg aggtgcttgg 2924641 ttcggccggc accgcgatat tgattgccgc agtgctgtca aaattcatca cggcgatttc 2924701 gtggaaagac tggggaaccg tttttaaaga aacagtccag gaattgaagc ttccgatttt 2924761 gaccattgct tctgtcgttg gttttgccta tgtcaccaac tcctcgggaa tgagcacgac 2924821 actcgggatg acactcgcgc tgacaggttc gatgtttacc ttcttttcgc ccgttctcgg 2924881 ctggctcggc gtcttcatta ccggctcgga tacttctgcc aacctgctgt tcggcaacct 2924941 gcagaaagtc accgcattat cagtcggcat ggaccccgtt ctgtctgtgg ccgccaactc 2925001 ttcaggcggt gtcacaggaa aaatgatttc accgcagtcg atagcggtgg cgtgcgccgc 2925061 ggtaggactc gccggaaagg agtcagatct tttccgcttt accattaaac acagtctgtt 2925121 tttgctgctg ctcgtctgta tcatcacctt tttgcagcat cacgtattca gctggatgat 2925181 tccttaaaaa aatcctcccg tctagggagg attttattta tatcgctttc tcgctgccga 2925241 tgacggaata ttcatttgat cgcgatattt tgccacggtg cgtctcgaga tttggatgcc 2925301 gtgttgttca tacagcaaat cgacaagctt ttggtctgaa agcggttttg ttttgtcctc 2925361 ttgattgatc aggttttcca gatgcgtttt gactgcataa ttcgacgcat ctccatcacc 2925421 tgaagcctcg gcttttgctg agaaaaagag tttcatctca aacagcccgt aaggcgtttg 2925481 tattgttttc cctttaatgg cccggctcac agttgattca tgaaggctta gacagtctgc 2925541 cacctctctg agagtcagcg gcttcattgc gcttcgccct ttcagaaaga aatccttttg 2925601 gcgtgtgatc agttcattga taattctcgt gattgtctgt tttcgctgcc gcagcgcgcg 2925661 gctcagccag cgccactcct gatatttcgc agataaatag gagacagtat cctgacagga 2925721 gccggatgat aaaagcgttc tgtactgcgg atgcagatcg atctcgggaa acgagcgggt 2925781 attcagttcc gctgcgatgt gcccattttt tacggtgata aaaatgtcag gctcaatata 2925841 cacatcttgc tctggccggg caaacagaag gccaggtcta ggatgaagag ccgcgatatc 2925901 atctgagata tcttgaatgg tatgaagcgg aattcccgtc tctactgaaa gcgttttcca 2925961 ttttttttgc gcaaaagcat caaaatgagc tgaaaccagc atttccgctt gttcatttct 2926021 gttcggcagc cgctgtaatt gaagaaggat gcattcctgc aaagatctcg cgccgattcc 2926081 agccggttct aacgactgga gttttgccaa aacagcctcc gcttccttgg ccgatacaga 2926141 taatcgccgt gctgcctcct ctatatcttc ttccaagtac ccgtttgaat caagcgaatg 2926201 aatcagataa ttaaaaatct ttttttcagt gtttgtcaga ttcatatcga gtgactgctg 2926261 ttttaacgca tcctgcaatg ttttttgcgg attacttaat tgaaggcccg cttcctgtgc 2926321 attcatcctg tttttgtttg ttttatggta agatagtggc ggtgtgtctg tttcctttcg 2926381 ttcaataaga gggttttcca gtgagagctc atcaatgtac tcggcgagtt ctgccgaatg 2926441 atagccaagc agcgtgatgg cctgcctgag ctcctgtgtc agttgaggct ttaatacttg 2926501 tacttgctga agtttcatat ccatcttgct cactcccctt tcttcattgt acatgattga 2926561 gatcacaccg tatacattta tgaaaaagga gctgccaaag aaatgtctga acttttttcc 2926621 gtcccttatt ttattgagaa tttaaaacag catattgaaa tgaatcagtc tgaggataaa 2926681 atccacgcga tgaacagcta ctaccgttcc gtcgtctcaa cactagtgca ggaccagctg 2926741 acgaaaaacg cagttgtcct gaaacggatt cagcatttag atgaagcata caacaaagtc 2926801 aaacgtggag aatcaaaata aaccttccga attcgggaag atgatgatcg gttaaagggc 2926861 taacgttcgc atctataggg gaaatctgtt tataatgggg gaaaaaggga gagaacacaa 2926921 tgactcatca aatagtaacg actcaatacg gcaaagtaaa aggcacaacg gaaaacggcg 2926981 tacataagtg gaaaggcatc ccctatgcca agccgcctgt cggacaatgg cgttttaaag 2927041 cacctgagcc gcctgaagtg tgggaagatg tgcttgatgc cacagcgtac ggctctattt 2927101 gcccgcagcc gtctgatttg ctgtcacttt cgtatactga gctgccccgc cagtccgagg 2927161 attgcttgta tgtcaatgta tttgcgcctg acaccccaag taaaaatctt cctgtcatgg 2927221 tgtggattca cggaggcgct ttttatctag gagcgggcag tgagccattg tatgacggat 2927281 caaaacttgc ggcacaggga gaagtcattg tcgttacatt gaactatcgg ctggggccgt 2927341 ttggcttttt gcacttgtct tcatttaatg aggcgtattc tgataacctt gggcttttag 2927401 accaagccgc cgcgctgaaa tgggtgcgag agaatatttc agcgtttggc ggtgatcccg 2927461 ataacgtaac agtatttgga gaatccgccg gcgggatgag cattgccgcg ctgcttgcta 2927521 tgcctgcggc aaaaggcctg ttccagaaag caatcatgga aagcggcgct tctcgaacga 2927581 tgacgaaaga acaagcggcg agcacctcgg cagccttttt acaggtcctt gggattaacg 2927641 agggccaact ggataaattg catacggttt ctgcggaaga tttgctaaaa gcggctgatc 2927701 agcttcggat tgcagaaaaa gaaaatatct ttcagctgtt cttccagccc gcccttgatc 2927761 cgaaaacgct gcctgaagaa ccagaaaaag cgatcgcaga aggggctgct tccggtattc 2927821 cgctattaat tggaacaacc cgtgatgaag gatatttatt tttcaccccg gattcagacg 2927881 ttcattctca ggaaacgctt gatgcagcgc tcgagtattt actagggaag ccgctggcag 2927941 agaaagttgc cgatttgtat ccgcgttctc tggaaagcca aattcatatg atgactgatt 2928001 tattattttg gcgccctgcc gtcgcctatg catccgcaca gtctcattac gcccctgtct 2928061 ggatgtacag gttcgattgg cacccgaaga agccgccgta caataaagcg tttcacgcat 2928121 tagagcttcc ttttgtcttt ggaaatctgg acggattgga acgaatggca aaagcggaga 2928181 ttacggatga ggtgaaacag ctttctcaca cgatacaatc agcgtggatc acgttcgcca 2928241 aaacaggaaa cccaagcacc gaagctgtga attggcctgc gtatcatgaa gaaacgagag 2928301 agacgctgat tttagactca gagattacga tcgaaaacga tcccgaatct gaaaaaaggc 2928361 agaagctatt cccttcaaaa ggagaataaa tatggggaaa acaggataca ttggtgctgc 2928421 cattgttgtg gcagcttgta tcattatttt gtcggccgtg gtatgtttac gggacacagt 2928481 ctattaccag cctatgcgct ggactggcat catactgttt ttcgcgggaa ttgtgatggt 2928541 tcccgcatac tcagcaaaaa gaaaacccgg aaaagagaag taattctctt ttccgggttt 2928601 ttatgtttat tataatcttc ccgcgcgaat atcgtctgtc attccctcat aaggagcctt 2928661 cgaaatcact tcttcgttgt cgactccttc atttttcaga aatgtaattt ccgcaaattc 2928721 aggtacaacg tattttggat acgtttcata tttttcgcgg gattctttca tcaaatcaat 2928781 gtggtcattt tggtagcaaa ccgtaatttc aggatgttca tgcacccatt tcgggaagaa 2928841 aataatgcca tgcatgcgtt tttcatttgg cataaagttt aatgaaacat ccgtgccagt 2928901 cggctctgtc caagacactt tatatacgcc ttctgtcagt ttgacaatat tcacttcctg 2928961 atctcgaacc cagcgtccgg caaccattcc gctatgaatt ctataatcaa ttgtatggtc 2929021 gtttttaata taaatctcgt attcccatcc gttttcatac gtataaatca tgtggcttcc 2929081 gataaagttt tccatcttac acactctcct tagtctttta ctgtacttca taaatgtcta 2929141 gtagaacgta atcaggggtt ctttctgcgg aaccgataaa caagcggtca tggagccatt 2929201 gatagacttc actgcctgtt tcaaacgtcg gtaccgtacg aaaataaaca tgctccggtt 2929261 caataatttc cccggctgcc gcttgttttc gaaacggctt gctgacttgc cgtattccat 2929321 tgttttcaat gtaaatcagt tcatgatctg ctgtttcaat cacatacctg gcagataaat 2929381 ctgttctgcc gttagcgcga atcatttgtg aatcggcacc gcccggcaaa atacgtccct 2929441 ttacttcccc ggttattgtt cccgaacgaa tcggaatgaa tcatctcagt cccaggcttg 2929501 tctcaccaat cgtgataggc ggatcaacct tgatttctaa agaggcgaat ggttttaaaa 2929561 ccggcttctt cacgagaacc acctcacctt cagaaaaaat catgtaacta tttacatgtt 2929621 cactttaaca ccattgcagt taactgtcaa acaataggaa cataaaaaaa caaggactgt 2929681 ttgaagacag tccttgtctg aagctagctt tgataagcaa gatatgtgct gacagtgctt 2929741 ttggcaagac aggcagagga atctataatc ggaatctcac tttgaatatg atctaacacc 2929801 gcatttaaat ccgtgcaggc tgaaatgatg atgtctgcat gctgactgat ttcttcatat 2929861 agcgtctgcc acaatgcttg tgtatgctgc atatgatttg gctgtttgat tgcggcgata 2929921 agctggttca cagcctgctg ccaatggtcc ttgtgaataa cttcttgtcc atttcccttc 2929981 agaacttttt ggtagatggc ggattggatg gttggctctg ttcctaaaac caccgctttt 2930041 tttgcgggat gcggaatctc ttttatcgtt tcctcaacaa tatgcaacat aggaactgac 2930101 aatgcctgct gaatctcttc atagtagaca tgcgccgtat tacaaggcag cgcaatgaaa 2930161 tccacgcctg ttttctcgag ctttaccgct ccgtcgataa tcgctttttt catctcgtca 2930221 tggtcaattg gacgatctgc atagaagggc gtcgggcatg aatagatcat catgtgcgga 2930281 tagtcaatat cgtttgaagc cccatacagc ttctgacagt aatcaatcac cttatcaata 2930341 aacggcgagg tcgatttcgg ccccattccg gctaatattc cgatcatcaa attcattcct 2930401 ttctacttcg tacggaccgc ttcttcctct gagccatcct catagaggat aaagcttttc 2930461 gcagcatcct cacctaatgt aaactcgact tcaacagaca atgctcgcag aaagaaacgg 2930521 gtttccgagg aaggaaataa ctccagtctc agctgtccgg cgatctccaa ataaagccgt 2930581 tcattctcgg ttgtcacctg tgcagccgtc ccatcctgca acaggtagct gccaacatag 2930641 cggctgtata tcgccgtatc aattgctttt ttctttttat cagcaggacg ttccgggaca 2930701 tcatatggct ggccaaatag aatatgttcc gccgccttca gaatcgcttg ttcatattca 2930761 gtatcctctt ccttattact caaatagatc agcgttttac gatgatcgat atatcggatc 2930821 atcatcgtcg aatagccggg ccatcctccg ctgtggctga caatccgccc tttttcagga 2930881 ctgttttgca gcacccagcc aaagccataa tcaattgttt ctccattgtt gaggcgcact 2930941 ggagaaaacg cagattcctt agaagccttg ctgatgaaat cgtcctgata taaagcctga 2931001 tcaaatcgaa acaaatcgct tgtgacagag ttaaccgtcc catctccctg tatgccatcg 2931061 agatacacaa catagttcgt ttcctccagc tcatcaggga ggacgtatgt ttcggaatgt 2931121 acatcataca catatccata tgcataatga tcaattcgct caggcgaaag cctcctgtta 2931181 tacactcttg tttcattcat gcctgccggt aaaaaaatac ttgtttttat aaaatccgca 2931241 tagctcatgc cagatgcttt ttcaatgata accgccagca gcacataccc cgtattgctg 2931301 tacatccagc cttcattcgg ttcaaaataa ccagatagcc cctcattcat cagcatatcg 2931361 acaatatcct gattcaccgc aatcttgtgt gaatcccaat tggcaaaaaa ccatcccata 2931421 taatcaggaa gccctgacgt atggttcaat aaatgccgaa tcgttacgcc ctgatacgga 2931481 aaaccgggca gccagcgatc cactttatcc tcatagccaa gaatcccctt ctcctccagc 2931541 aagatgattc ccaatgctgt aaaaggcttt gacaaagacg ctaactcaaa caaagagttg 2931601 gttttcaacg ggcgtttttc cgtcatttcc gcatagccaa aagagtggtg atataaaata 2931661 tcgccaccct ccgcagccag aaccgtcccg ttaaactgat gtttttcgcc taatgtctca 2931721 aataacgtct gaagatgctt tcttttattc tgcttcattc ctccacctcc catatctctg 2931781 tacgttacta acctactaac gtttcaaata ttttgaaaaa tccttcagtt agagatcctt 2931841 tttaacccat cacatatacc tgccgttcac tattatttag tgaaatgaga tattatgata 2931901 ttttctgaat tgtgattaaa aaggcaactt tatgcccatg caacagaaac tataaaaaat 2931961 acagagaatg aaaagaaaca gatagatttt ttagttcttt aggcccgtag tctgcaaatc 2932021 cttttatgat tttctatcaa acaaaagagg aaaatagacc agttgcaatc caaacgagag 2932081 tctaatagaa tgaggtcgaa aagtaaatcg cgcgggtttg ttactgataa agcaggcaag 2932141 acctaaaatg tgtaaagggc aaagtgtata ctttggcgtc accccttaca tattttaggt 2932201 ctttttttat tgtgcgtaac taacttgcca tcttcaaaca ggagggctgg aagaagcaga 2932261 ccgctaacac agtacataaa aaaggagaca tgaacgatga acatcaaaaa gtttgcaaaa 2932321 caagcaacag tattaacctt tactaccgca ctgctggcag gaggcgcaac tcaagcgttt 2932381 gcgaaagaaa cgaaccaaaa gccatataag gaaacatacg gcatttccca tattacacgc 2932441 catgatatgc tgcaaatccc tgaacagcaa aaaaatgaaa aatatcaagt tcctgaattc 2932501 gattcgtcca caattaaaaa tatctcttct gcaaaaggcc tggacgtttg ggacagctgg 2932561 ccattacaaa acgctgacgg cactgtcgca aactatcacg gctaccacat cgtctttgca 2932621 ttagccggag atcctaaaaa tgcggatgac acatcgattt acatgttcta tcaaaaagtc 2932681 ggcgaaactt ctattgacag ctggaaaaac gctggccgcg tctttaaaga cagcgacaaa 2932741 ttcgatgcaa atgattctat cctaaaagac caaacacaag aatggtcagg ttcagccaca 2932801 tttacatctg acggaaaaat ccgtttattc tacactgatt tctccggtaa acattacggc 2932861 aaacaaacac tgacaactgc acaagttaac gtatcagcat cagacagctc tttgaacatc 2932921 aacggtgtag aggattataa atcaatcttt gacggtgacg gaaaaacgta tcaaaatgta 2932981 cagcagttca tcgatgaagg caactacagc tcaggcgaca accatacgct gagagatcct 2933041 cactacgtag aagataaagg ccacaaatac ttagtatttg aagcaaacac tggaactgaa 2933101 gatggctacc aaggcgaaga atctttattt aacaaagcat actatggcaa aagcacatca 2933161 ttcttccgtc aagaaagtca aaaacttctg caaagcgata aaaaacgcac ggctgagtta 2933221 gcaaacggcg ctctcggtat gattgagcta aacgatgatt acacactgaa aaaagtgatg 2933281 aaaccgctga ttgcatctaa cacagtaaca gatgaaattg aacgcgcgaa cgtctttaaa 2933341 atgaacggca aatggtacct gttcactgac tcccgcggat caaaaatgac gattgacggc 2933401 attacgtcta acgatattta catgcttggt tatgtttcta attctttaac tggcccatac 2933461 aagccgctga acaaaactgg ccttgtgtta aaaatggatc ttgatcctaa cgatgtaacc 2933521 tttacttact cacacttcgc tgtacctcaa gcgaaaggaa acaatgtcgt gattacaagc 2933581 tatatgacaa acagaggatt ctacgcagac aaacaatcaa cgtttgcgcc aagcttcctg 2933641 ctgaacatca aaggcaagaa aacatctgtt gtcaaagaca gcatccttga acaaggacaa 2933701 ttaacagtta acaaataaaa acgcaaaaga aaatgccgat atcctattgg cattttcttt 2933761 tatttcttat caacataaag gtgaatccca tatgaactat ataaaagcag gcaaatggct 2933821 aaccgtattc ctaacctttt taggaatatt gctgtttatc gacttatttc caaaagaaga 2933881 acatgaccaa aaaacaaaat caaaacagaa gccggactac cgggcggcat atcattttac 2933941 gacgccggat aaatggaaaa atgaccctca aaaaccgatc tattttgatg gcaagtatca 2934001 ttatttctat ctatataacc gggattaccc aaaaggcaac ggcacagaat ggcgccatgc 2934061 cgtctcagag gatttggtgc actggaccga tgaaggcgtg gcgattccga aatatacaaa 2934121 cccggacggt gatatttgga ccggttccgt cgtggtggat aaagagaaca cagccggctt 2934181 cgggaaaaat gcgcttgtcg cgattgtgac acagccctca gccaaagaca aaaaacagga 2934241 acaatatttg tggtacagca cagataaggg aaaatcattc aaattctaca gtggcaaccc 2934301 cgttatgcct aatccgggca cagacgattt cagagatccg aaagtcatat gggatgacca 2934361 agataacaaa tgggtcatgg tcatggctga aggatcaaaa atcggctttt atgaatccga 2934421 taatcttaag gactggcatt acacaagcgg attcttccca gaacaggcgg gaatggtgga 2934481 atgtcccgac ctctacatga tgcgggcaag cgacggaacg aataagtggg ttctcggtgc 2934541 cagcgcgaat ggcaaaccgt ggggcaaacc aaatacgtac gcctactgga ccggaagctt 2934601 cgacggaaaa gaattcaaag cggatcagac tgaagcccaa tggcttgact atggcttcga 2934661 ctggtatggc ggtgtgacgt tcgaagacag caaaagcaca gatccattag aaaagcggta 2934721 tgcgcttgcc tggatgaaca attgggatta tgccaacaac accccgacaa tgaagaacgg 2934781 ctttaacggc acagattctg tcatacgcga actccggctg aaggagcagg atggaacata 2934841 cagcctcgtc tcacagccga ttgaagcttt ggagcagctg actgtttcaa ctgacgaaat 2934901 agaggatcag gatgtgaacg gatcaaaaac attgtcgata acaggtgata cgtaccagct 2934961 tgatacggat ctttcttggt cagagctaaa gaatgcaggc gtcaggctca gagaatcaga 2935021 agaccaaaaa cgccatattg atgtcggcat tttcgctgaa ggcggctatg cttatgtcaa 2935081 tagagcagcc acaaatcagc ctgacaaaag caatacctat gtcgaaagca aagctcctta 2935141 tgatgtaaac aaacgtaagg tgcatttgaa aatacttgtc gataaaacaa cgatagaagt 2935201 atttgttggc gacgggaaaa ccgttttttc aaatgaagtc ttcccaaagc ctgaagataa 2935261 aggaattacc ctttattctg acggcggcac agcctccttc aaaaatataa cagtgaaaca 2935321 ctttgattcg attcatgaat aaaaacaggg gcggcgcagg ctgcccctgt ttttttatta 2935381 ggagcggtat tctctgttac atattgggca ttgtaaggaa tataaggctg gtttcaaagg 2935441 aggaagcgaa tgtctaaaca aggaaatttt caaaaatcaa tgtcgctgtt tgatctgatt 2935501 ttgattggga tgggagccat ctttggatca gcgtggctgt tcgctgtcag taatgtcgct 2935561 tcaaaagcag ggccctccgg cgctttttcc tggatcctcg gaggagccat tattttgtta 2935621 atcgggcttg tatatgcgga gctcggagcc gctctgcccc gtaccggagg catcattcga 2935681 taccccgttt attcacatgg ccaccttgtc ggctacttaa tttcgtttgt cacgattgtc 2935741 gcttatacaa gcttgatttc aattgaagtg acagctgtgc gccagtatgt ggcctattgg 2935801 tttcccggcc tgaccattaa agggtctgat tcgcctacca tttccggctg gatcttgcag 2935861 tttgccctat tatgcttgtt tttcctgctg aattattgga gcgtcaaaac cttcgctaag 2935921 gcgaatttca tcatatcgat ttttaaatat attgtgccga ttaccatcat tattgtgctg 2935981 atctttcatt ttcagccgga gaatttatcc gttcaaggat ttgcaccgtt tggatttaca 2936041 ggtattcagg ctgccatctc gacaggcggc gtcatgtttg cgtatctcgg cctgcatccg 2936101 attgtatctg tagcaggtga agtccaaaat ccaaaacgca atatcccgat cgctttaatc 2936161 atttgcatca tcgtttcaac catcatttat actgttttgc aggtcacctt tattggtgca 2936221 atcccgacag aaacactgaa acatggctgg ccggcaattg gccgggagtt ctcattgccg 2936281 tttaaggata ttgcggtcat gctcgggtta ggctggcttg caacgcttgt cattttagac 2936341 gccattctgt ctcccggagg aaacgggaat atctttatga atacgacatc ccgccttgtt 2936401 tacgcctggg cgcgtaacgg cacattattt ggcatattct caaaggtcaa taaagatacg 2936461 gggacacccc gcgcttcgct ttggctttcg tttgccctgt ccattttctg gacacttccc 2936521 tttccttcgt ggaacgcgct cgtcaatgtc tgttcagtcg cgctcattct ttcatatgcg 2936581 attgcaccca tttcttcagc tgcgctgagg gtcaacgcga aggacttaaa caggccgttt 2936641 tatttaaagg gaatgagcat tatcgggccg ctttccttta tatttacagc gtttatcgtg 2936701 tactggtcag gatggaaaac agtctcctgg ctgctcggtt cacaactcgt gatgtttttg 2936761 atctatctct gtttcagcaa atatacgcct aaagaagatg tcagccttgc tcagcagctg 2936821 aaatcagcct ggtggcttat cgggttttat attatgatgc tgatcttttc ctacatcggt 2936881 tctttcggac atggtttagg gattatcagc aatcccgtcg acctcatttt agtcgcgatc 2936941 ggctcacttg cgatttatta ctgggcaaag tataccgggc tcccaaaagc cgccattgat 2937001 tatgataaat aaagaagcaa gaggttttct tgcttcttta ttctttacaa acaaacatac 2937061 acgcgataaa atgaatgaga gtcagtcatt actggaggtg ttcctcatgc caaaacaaac 2937121 atcgggtaaa tacgaaaaaa tattgcaggc ggccatagaa gtcatttctg aaaaaggcct 2937181 cgacaaagct tctatttctg atattgtcaa aaaggccggc actgcccaag gaacattcta 2937241 tttgtatttt tcatctaaaa atgccctcat accggccatt gcagaaaatc tcctcaccca 2937301 tacacttgat caaatcaaag gtaggctcca tggggacgag gatttttgga ccgttttaga 2937361 tatattaatt gatgagacat ttctcattac agaacgccat aaggatatta ttgtcctctg 2937421 ttattccggg cttgcgatcg accactccat ggaaaaatgg gagacgatct atcagcctta 2937481 ttattcctgg cttgaaaaaa tcatcaacaa ggccattgca aaccatgagg taacggaagg 2937541 aatcaattca aaatggacgg ccagaacgat tatcaacttg gtcgagaata ctgcggaacg 2937601 attctatatc ggatttgaac aagatgaaaa tgttgaagtg tataaaaagg aaattttcac 2937661 tttcttaaaa cggagcttag gtactgctta aaaaatgact gggtaacacc gctcattttt 2937721 taatgcccta aaaatgactg acgttcattc ataaaataga gaggtgtttc atttgaattg 2937781 ggttcttgtt tttattgcag ggcttttaga ggttgtttgg gcctcttccc tcaaacatgc 2937841 cgattcgctt ttggattgga tcatcatttt tatcttaatc gcggtcagct ttatcctgtt 2937901 gatccgctct tatcaaaaaa tcccgatggc cgcggcgtac actgtgtttg tgggaatcgg 2937961 aaccgtcgga acatatctga ctggaattgt tctgggcgaa tccttctcag cagcccaaat 2938021 gttcttttta gctttattgc tggctggcat tttaggaatg aaattattta cgaaagaaag 2938081 caaatctcag ccgggaggtg aaaaataatg gcatggtttt tattagtgat tgccggcata 2938141 gaagaaatta tagctgccat tgccatgaaa tatatagacg gaacaagaaa aaaatggccg 2938201 atcattgtga tgactgttgg attcggctta tccttttact gcctgtccca agcgatgatc 2938261 gtcctgcctg ccggagtcgc atatgccgtc tggactggca ttggaagcat tggtgtttcg 2938321 gcggtcgggc tcatctggtt taaggagcgg tttcagcttt cacaggtgat ttcactttgc 2938381 cttatcctag ccggcgtcat cggcctgcgt cttacgtcat cttcataaaa tcaaggcata 2938441 tacagctgta tatgcctttg ccattaagct tcgtgatgtt tttgaagatg aagcggcggc 2938501 gggatgagcc agcctttgtt ttttagcagc cttaagtatt ttgcgccggt tgccgctttc 2938561 gacatatgaa attgcccaaa catcatggca atatcctcac gaatcgattg ccccatcatt 2938621 ttgctgcatg tcacaagacc tgcagcattt tctgctgccg cggaagccgc cacatccgga 2938681 tcgagaaacc gtgcaccagg cggaatatcg ttaagatctg ctgtcggcgg ttcaggagaa 2938741 gccggcggca gcgccacccc gttttctttc aggatcgtgc tgacctgttt gatttcatct 2938801 tggcatttct caatagactc acgaagcagc ttcttcaggt cgtcatcacc gacatgattc 2938861 aatagcattt ggtaattgcc gaccatttta ttgcccgcca tcacataact ccacaagccg 2938921 aatacctcac cgtaatgcat cggttcatcc tgcggatttc cgcttaaaat acccatgctc 2938981 attctcctcc catattcaat attgcacatt tcataacgtg cccaagcgga ggaacattta 2939041 tgtttcagcg gaaaagattt atgaaatgaa acaaaacaaa aaagacaaga gtggcaagtt 2939101 gccaaaccat tgtctttcct gttgtttgat tggacgcact gaagggattc gcaccccgac 2939161 agacaagata ccggaaacca ttcaagtgct ttttagtatg agtcattgat tctgtcttta 2939221 ataaacttta acgagatggc gggatgcttt gcggaaaacg aaatacattt tcggggtcat 2939281 atttcgcctt tatttctcga agccgcgcaa agtttgcgcc ataatattct tttccgaagt 2939341 tttcaatgtt ttgatctgga acattaacat atgaacctgc tacatatggt tgcatcagct 2939401 gacgcactct ttcaactgat gcaagatttg aatcttcttg tgatttattt ttccaactag 2939461 ccgtccattc cgtataaaat aatggatggc gccaaaaaaa ggcagtttcg tctttaggga 2939521 ctctgcttat agcaccaccc caattgataa aaaagaaatt ggcttctgtt ccagtagcat 2939581 cttccaaaaa ttttctcatg attgaaatgg gttcgtcaga ccaaaaatca tgaccccatg 2939641 ccgaggagaa tttaacactc tgatcatttc tgccagggat gggttcgtca gggtctaaga 2939701 aatctatagc atctggatag tataatgttt tgatatctgc ttctgttgga gttcccgcat 2939761 gtaataaagg ttttaataat cgaatcaatt cagttttcga accgaggaaa attccttctg 2939821 catgacacaa accatttatt ttgctgtaaa tttcaaggta gcatcctaat cgttcatcta 2939881 caaacggagc ccatttctgc caagctttaa ataccgtttc taattgttcc cacggccaga 2939941 taatattgaa gacggttgca gttttagggg cacgatgaac tttgaatgta tattgggtat 2940001 tatatccaaa gttacctcct cctccgcctc tagaagccca tagcaaatcc tcattgtgag 2940061 attgatctgc gtgaataatc cttccttttg catctaccgt tttcagcgcg agaaggttat 2940121 cacttataag gccaatcgat cgtgagagta caccaaatcc gccgcccatc gtaattcccc 2940181 cgattccaac tgttgggcta tctccaaacg gagccataaa accgtctcga gctaatccct 2940241 ttacaagcgg gccaacggga ataccagttt gaacggttgc aatagcgttt tcttcatcta 2940301 agaaaacttt attcatgtca ctcacatcaa taacaattcc tccacttact actgaaaggt 2940361 tcttatctaa agcatggcga ccgcttctga cacgtaaggg cactttattc tcacgagccc 2940421 atttaatggc attacttaca tcgtatgaat tttgcgcaaa aacaaagaca agaggataga 2940481 catccacata agggttccaa ttcttaatag cctctgtata gccggggtct cctttgaaga 2940541 ttacacgccc tgtcaactgt gttgatccca tatattattt cactcccaaa gaaattcgat 2940601 tcagatacta aaatatgcag gagctggata atcgcataga caaatgatct acgaactata 2940661 aatataatac gctaaggcct ttttcgtcgg tgaggtctgc tgagaaacat ttttcaaaca 2940721 attttgagca aacttcctgt ccaatcctcc aacaagcgtt ttttcttatc gtttttagga 2940781 gcagtgtcca gtttttttcg gagtgaatat tcgtttaggc caaaagaaaa gagagatgaa 2940841 gaagtgttta gtaccagagg tatacatcca tacaacagac tctagatcat catatactga 2940901 atgtatgtag aaaggagaca tcagctttgg caaaatatcg gattatgacc tttgacggcg 2940961 gcggtacctt aggtgcttta agtttacaac tattaaacag attggctagg caaaacccga 2941021 agttaattag tcgaacccat gtattttcgg gaaattcaat cggttcattt actgcccttg 2941081 cattagcaag cggaagatct ccgagggaaa cacttcagta ttttgaggat gaaatcctac 2941141 ccgcattcag catttcccgg ccaggcggac ctgttttcaa ccaacaatta ccctattccg 2941201 gttttattaa agcggtaaga aattttttcc cagcagatct tcaacttata gatttaagaa 2941261 aacgaattgt tgtcccatca ttcaaattat actctcaaaa actggaccgt tggactcctg 2941321 tcttatttca caattttccc ggctctccct atttaaatga aaaagtgagt gatgtcatac 2941381 tgcggagcag cggtgctccc gcgacgcaac gcgcctatca aaactatgtg gacggatatg 2941441 tagtagcaac gaatcccagt acagccagta tcgcgtttgc agttggtaaa gccaacgtgc 2941501 cattggatca aattgcggta ttgtccatcg gaacaggtga agccccgact cggttaagaa 2941561 gagatacgag gggatgggga atggtaagtg cagataacat acgtcccgaa aatctgaaga 2941621 accttcctcc aaattgggga gtccttttgg acaggtcgcc taatgaacct ttactgccat 2941681 ttcttcagat gattgctggc ggtaatgggt actatgaatc catggtcagt gcgaatcttc 2941741 tgggagatcg ttttttccgg ttagatccgc ggattccgaa cttctccaaa acggaccctg 2941801 ccgtcgttcc cgctgtcatt gaaattgcga acaaaacaaa cttacagcct gcgaatcaat 2941861 ttatagagaa gaactggggg agcaaataat tatttatttt aaatcaattc tcgcttatac 2941921 aattttgtcc gagagaagat tctcaaaata aatacaggca atgggtagaa ccggattttt 2941981 ttaaaggttt gttaatcaca agctaataag atgaatgaaa aaatcaattc atacttcttc 2942041 ttttgaaagt gagggttcaa actaaagaat gtaattgaaa tgttactcta aggtatgcaa 2942101 ttcccttttt cacacaaaaa aagacaagag cggcaaatcg ccaaaccctt gtctttcctg 2942161 ttgttctatt ggacgcgctc ggagggattc gaacccccga cagacgtggt accggaaacc 2942221 accgctctat ccaactgagc tacgagcgca tatagactgc gttatgagaa cgtcagcaca 2942281 actaattata cgataattcc tttcaaataa caaccctcta tttcgagagg ccgtttttta 2942341 aatagacaaa gcatcttaat tggcaatctg acatacgatg gtttgaaccc ctgtattttt 2942401 ggggaaaatg ggaaaaagag acgactttgc atatcaggcc agctttttgt ttgaccttta 2942461 ttgaccaaaa atgtatcatg taactacata cttacctaaa aggtgaagga ggagcattat 2942521 gaatttaata cctacagtca ttgaacaaac gaaccgcggg gaaagagcgt atgacattta 2942581 ttctcgtcta ttaaaggatc gtatcatcat gcttggatct gcgattgatg acaacgttgc 2942641 gaactccatc gtgtcacagc ttttattctt agcagcagaa gaccctgaaa aagaaatttc 2942701 tctttacatc aacagcccgg gcggctctat tacagccggt atggcgatct atgataccat 2942761 gcagtttatt aagccgaagg tatctacaat ttgtatcggt atggctgcgt caatgggcgc 2942821 gttcctgctt gcagccggcg aaaaaggcaa acgctatgcg cttccaaaca gtgaagtcat 2942881 gattcaccag cctcttggcg gtgcgcaagg tcaagcgaca gaaattgaaa ttgctgcgaa 2942941 acgcattctc ttgcttcgcg acaaattaaa caaagtccta gctgaacgta ctggccagcc 2943001 gcttgaagtg atcgaacgcg acacagaccg tgataacttc aagtctgctg aagaagcgct 2943061 tgaatacggc ctgattgaca aaattttgac tcacacagaa gacaaaaagt aataacacaa 2943121 cctgcaagag ctgcgtctct tgcaggtttt tttcatttca aggaattgac tcccttattc 2943181 tatactgctc ccattcctca tgtaacagct caagcgtcaa atcactcgtc tgcctcacaa 2943241 ccagatcagc accaagcatc ggctgtcctt gaccgacacc aaccgcaaac atccccgcag 2943301 atttgattgc agaaatgcct gcttctgcgt cttctattgc cgcgcaatca gcaggggaaa 2943361 catcgagcat cgctgcagct gttaaaaaga tgtcaggatc aggcttcccc ttcgcaagag 2943421 tcgtcggatc aacaatggca tgaaaatcat cgataattgc caagcgtctt aaaatcttag 2943481 gagcattgcg acttgaagat gctaacccga tttttatatt ttcgtttttc aattgacata 2943541 gaagcctgcc aatccccggt aaaagatctt ccggcgtcaa tttgctgatc agcatttgat 2943601 aatcgcgatt tttccgatgc ataagctctt gtttctccgc atttgtatac tttgtttccg 2943661 ccccgccaaa gatcaatatg ctttcaagtg actcttctct gctgattcct tttagccttt 2943721 cattcatgtc tctgtcaaaa gggatatcga tttgttctgc gatgtgcttc caagcgagaa 2943781 aatgatattc agcagtatct gttatcactc cgtctaaatc aaaaatgacc gctttcatat 2943841 actaatgccc atcacagctt cataaggttt gaggctaata ctctttaagt cagcccgctc 2943901 ctgcggatag tttgaaatta gcactttcca acgctcatga atcagttctg gaggcgcttc 2943961 gaacagagcc ttttcttccg ataaattcac aacgacaaga agcttttccc ctcgatattc 2944021 tcgaaggtaa gaaaagacct gcggatcatt ctcctgcaac agctgataat cgccatatat 2944081 cataatctta tattgctttc gtaattgaat gagcttctga tagtaaaaga aaatcgaatc 2944141 ttgatcttcc aaagactctt tcacattgat atcttgatag cgggaattta ccggtatcca 2944201 cgggtctccg gctgtgaatc ccgcatgttt tccggcatcc cactgcatcg gtgttctcgc 2944261 atgatccctt ccttttatca tcacggcttt gacaaactct ttttctgaca tcgttttgtt 2944321 ttcgacgact agttcacgat atgcattctt tatttcaaga tcatcataca tctccagcgg 2944381 catatcgctg ttgaccatgc cgatttcttc tccctggtaa ataaacggcg ttcctttcat 2944441 gccgtgcaga accgttgcaa atgccttcgc acattcctta cgcagtttcc tgtcattgcc 2944501 ccagcgggaa ataaccctcg gctggtcatg gttctcaaaa taaagggtat tccagccgac 2944561 attcattaac ccggtctgcc accttgtcat cgtctttttt aaagcaatca aatcaaacgg 2944621 cttgatctgc catttcccat ttggcgagtt ttgttcttta tcaatatcca tatgttcaaa 2944681 tgtaaagatc atattcagct cttgcctgct tgcatctgtg tactttttcg cctcttcaat 2944741 atcagagccg tttgcctctc cgactgtcat gcagtcgtaa tgagaaagca cttccctgtt 2944801 catctcttga ataaactcat gaagacgtgg gccgttagag tgataacggc cgacaatata 2944861 gctgcggctg tgatccgttt cgtagtccgg aaaatcggtg tatttagaaa tagagccaat 2944921 cacatccatc cgccagccgt caacgcctct atccatccag aatctcatta catcataaac 2944981 ttcccggcga acggcttcgt tttcccaatt taaatcaggc tgttttttcg aaaagtagtg 2945041 caaataatac tgccctgttc cttcatcgta tgtccacgct gagcctgaaa agatcgatcc 2945101 ccaattattc ggctctgagc cgtccggttt aggatctttc caaagataat aatcccggta 2945161 aggattgtcc ttcgacttgc ggctttcagc aaaccaagca tgctcatctg atgtgtggtt 2945221 cacgaccaaa tccatgacga ttttcattcc gcgtttatgg acttcatcaa tcagctgaaa 2945281 catatcttca tttgtcccaa acttttcgta catgtttttg taatcgctga tatcatatcc 2945341 gttgtcatcc tgcggggaat caaataccgg ggagagccag atgacatccg ccccgaggtt 2945401 tttgatgtaa tccagctttt gaatcacacc ttgcaaatct ccgaatccat ctccattggc 2945461 atcataaaaa ctgcgcgggt aaatttgata aacgacagct tctttccacc attcactcat 2945521 taggcgttct cctttcacat cgtccctgta ggacaaccgg ttcctcataa acgttcatgt 2945581 gcagcggctc gccttttaca agctcaaaaa taacgcgctt ttcgtcaacc gtcacattga 2945641 ttaatcgatt tcgataattg atgttgaatg aatattcgtc ccattctttc ggcaaaaacg 2945701 gagcaaatga cagcgtctca ttcgcggtgc gcatgcctgc aaagccatga acgattgcca 2945761 gccagctacc cgtcattgaa gtaatatgca agccttcttc cgtatcatga ttgtaattat 2945821 caagatcaag ccttgctgtg cgcttatata attcgagcgc tttcttttcc agcttgagtt 2945881 cggctgcgag aatcgcatgg acagagggcg ataggcttga ttcatgaaca gtcatcggct 2945941 cataaaattc aaaatttcgc cgtttttctt ccattgtaaa acggtcatta aaaagataaa 2946001 tgccttggag aacatctgcc tgcttaataa aattggagcg gagaatcttg tcccatgacc 2946061 aattctggta aagaggccgt tccgctggat ctaattcgtc aactgtttgc aggtctttgt 2946121 ccaagaacgt gtcatgctga acgaaaattt gcagttcttc actaaatgga tagtacatgt 2946181 gctggatgat ttctctccag acttccaatt ctacttcctg cacatccaga tggcggcgtt 2946241 tctccgctga gatactttcg agactttgta gagtatactc caacgtccaa gccgcaatga 2946301 cattcgtata ccaattgttg ttaacgttgt tttcgtattc attcggccct gtgacgccat 2946361 ggatcatata cttatttttt cgtttcgaga agtgaacacg gtcggcccaa aatctgctga 2946421 ctgccacaag tacgtctatc ccgtattctt ccatatagtt acggtcgcct gtataattga 2946481 tataattgta gatcgcataa cagatcgcgc cattgcggtg aatttcttca aaggtgattt 2946541 cccattcgtt gtggcattca tcacctgtga acgtcaccat cggataaagt gcccccttca 2946601 tccccaattt tgcagcgttt cgtttggcag cctccaactg atgatagcga tacaaaagca 2946661 ggtttttcgt cacctccggc tcggctgtcg ccaaatacat cggaacggcg tacgcctcag 2946721 tatcccaata tgcggcacct ccatatttct cgccagtaaa tcctttcggc ccgatattca 2946781 aacgggcatc gcccccgtaa tatgtcgaga ataactgaaa gatattgtag cggattcctt 2946841 gttgaagctc ctcatctcct ttaatctcaa tgtccgcttt tgcccatctt tccttccatc 2946901 gatcagtgtg cctccgtttt gcatcttcat agccgttctc taccacatcc gccaaaagct 2946961 ccttggcttt cgataaaagc tcttcctccc gaaaatcacg ggaagtcgtg acaatcacaa 2947021 actttttcaa tgatgccttc gtttgataac tgtagcgatt ctcgacatac atttcagtcg 2947081 ttttaaagct ttcatggaca aaaccctccg tctcgtttgc cattgcggct aataccgtga 2947141 agcgcggtgt tccaaatgga ttttcgatcg tttttgccgc taaatggccg ctgtgagaat 2947201 cagcaccttt cgcttcctcc tgccaaaact gttcttggta gttagaatct tcatttgcca 2947261 catttccatc caggtaagga acaagcgtaa tgacagcatc tcccgtcaag cactccgctt 2947321 cataatgaat cgcacagagt tcttttacag caaggctaag aaaccgctct gacctgattc 2947381 tgacggtttt atcttgaatg cggacaacag cgcttcgccg cagaatcccc tctttcatat 2947441 tgagttctac ctcaaataat tcgattgggt tttgatggag atcgattttt tcaccgtcaa 2947501 catataggcc tatgcccata aagttcatcg cattgatcac ttttccgaaa tattctggat 2947561 acccgttttt ccaccagcct actcgcgttt tgtcggggaa ccacacgcct gcaatatatg 2947621 tgccttggtg actgtcgcct gaatagcctt cttcaaaatt ccctctgacc cccatatagc 2947681 cattggcaag agacgtcagg ctttccagca gccgtgtatg ctccttatta aatgtatttg 2947741 ttttgatttt ccattcatca atctcaaata accgctgatt tatcatcatt tcctcccgaa 2947801 tgtaagtttc cattatcacg gcgggttttg gtcaaatatc taaatgcaaa agagatcatc 2947861 aaagtaacgc cacacgaatg gatcatcaat acagtaatca aatcaaaatg aaccatgccg 2947921 atagcagctg ccgcaaatgc cggcagtgct gatgcgcaaa tcgctataga ggccgcttcc 2947981 ttgaatgatg caatagagac catgtttgat atttttgtga tccagaggcc acctgcaaga 2948041 acaaacgtta acaaaagctg gatcatagaa accaccgtat atgccagcat catgatcatc 2948101 ggcttatact gtgccaacca caatgtatcg atcaagacct ctacatcatg gacgtttggt 2948161 ttctcgagct taacgtccat tttcgcatag ccaacagaaa accccgtttc gttttgatcg 2948221 gtgatcacca gttgatcagg ttgaaatatg atggcgtttt caaatccagt tactttcaat 2948281 cgcccatttt caccgcttgt ctcatattca tgcttcatat cgactgccat cacattctgc 2948341 ccatcttcaa tcctctcaga gctcttcccg cctgttagtt ttccgttcct gatttgaaaa 2948401 ccctgcaatt gatcagcaaa ttgatcatta actccttgaa tcgctgacgg catgaaagat 2948461 gaaacgctga agcgatccat tttcacaaac gaaaccgcta acggcgccat taagcaggcc 2948521 gttaaaaaca gaaagagaaa agagagctgc agccagctga aggtattccc atagcggcaa 2948581 acacctgatg gggatgcagc cgccttcagg cagcggatga taaagctttt attctccaga 2948641 ttcttcattg gcattacccc tttgttccgc cggctgtcaa accggacaca aagttctttt 2948701 ggagaaaaaa gaatagaacg catatcggca gtgcggctag tatggcaccg gctgcaaata 2948761 gagctacttt ttgctgctgc ggattagaaa taaaggattg taatcctaca gcgatggtca 2948821 gcctttccgg tgagcgaagc agaaatttcg tcagcaaata gtcgccaaac ggtgccataa 2948881 acgcccaaag cgcttgtacc gcgagcattg gcttaacaag cggtagaaca attgaagcga 2948941 aaatcctcag atgtcccgct ccgtcaattc gcgcggcttc atcaatttct ctcggcacag 2949001 tatcaaaata acctttcatc agccacgtgt tcatcggaat tccgccgccg atatagatcg 2949061 ctgttaaaaa ccagtattga tcgagtgcgc ctattagcat cgccaagaca taaaaagcag 2949121 tcagcgccgc cattgtcggc accatttgaa tgattaaaaa gaatatcagg ctcttttttc 2949181 tgcctgcaaa ccgatagcgg ctgtacgagt acccggcaag tgtcacaatc gtaacctgca 2949241 aaaccatgac cgatagcgcg atgacaagtg tattgctgta ccaattgaga taaagcgttt 2949301 cgtcaaatag ccgcttaaaa tgatccaatg tccaagaacc cgaaaaatcg agctgaaaag 2949361 ccgccgaatt ccccacacgg aaggctgatg atgccgtaat cagcaacgga tatataatga 2949421 caatacttaa aagcgtcaaa aataaatacg tacagatttt attaagcatt ctggcagtgc 2949481 tcgcgttcac ctacataacc tcctcattgc caaaagcatt cgattttttg aaagcaatca 2949541 gtgaaattcc aatgacaatg aaagaaatta acagtgtcac agccgccgca acggaatatt 2949601 ggggtgatgt gcctgttgtc agtttataaa tccacgaaat taagatatcg gtcgatccgg 2949661 ccccggctcc cgcactgcct ggccctccct cattaaataa atagatgatc gagaaattat 2949721 tgaaattaaa cgtatactga gtaatcatca cgggtgctgt ggcaaataaa atcatcggga 2949781 atgtaatatg ccgaaaacgc tgaataaaag tggccccgtc aatctttgcc gcttcataca 2949841 attcacctgg aatcgcctga agcactcccg ttaccatgac atatatatat ggaaagccga 2949901 gccacgtttg aatcataatg agggctgtct ttgtccagaa aggatcggtc ttccacgcga 2949961 tcgcaggcag ctcgacaaac ggcaggtgat tgaataatgg tatcacctgt gcattcaccg 2950021 ctcctatgct gtcgttaaac atgttggaaa aactcatgat tgtaataaac gccggaacag 2950081 cccatggaaa taagaaaatc attcgaaata tccgcttgcc ttttataaaa tcctgattga 2950141 cgaaaagtgc cgtcacaata cctaaaatga tttgcagcgt tgttgcacag attgtccaga 2950201 taaccgtcca gcccagtaca ttcacaaatg tttcacgata ggagccaagg aaaaaaatat 2950261 ttaagaaatt tttaaacccg acccagtcaa tcagacgatt aggcggaata tgataaaaat 2950321 catagtttgt taatgcaaca aacagagtca ccaaaaccgg aaaaataatc acaaacacca 2950381 tcatgatata tgccggcagt gtaaatagat acggaaaacc tttatcgccc gcatgacaga 2950441 tcatatcctt ggctgttgta ttgacttcca aacccgccgc tttcatagcg gcggtcttac 2950501 gtgaatcatg aatattaaag atatagaaca tgaggaaaat cattgtcacg atcaattgca 2950561 gcgtgccttc aatcagcata aacagcgagt gatcttcacc gggaacactt cccaatgtca 2950621 tcaatccggt tagcgcctgt ataccgaaaa cgcataattc aaaagcaaac aagcctgtga 2950681 tggcaagaaa taagagcccc tttgacaact gctgattcgc aatctgccca agtcctggaa 2950741 tgatcgataa aagccctgcc tttcgttttt gctttgtaag tgtgtgatgt ttattcattt 2950801 ttccgccctc tattcttccg gacgctatcc cgccgtttta tttcacatac ttttctttaa 2950861 tattttcctt tatgacgttt acagcatcat tcgctgatgt ttgtgtcgat ttttttcctg 2950921 aagctgcatc aaaaattaaa ctttccgctc ctgtccatac ttcagccatt tccggaatat 2950981 ttggagtcgg cgttgctgtt tcatattgtt taatcacagc tgacgtcagt tcattctttt 2951041 gctcatcggc tttcttcctt gcagccgtgt tggccggaac ttcgtttgta tcctcataaa 2951101 aagcgtaagc attggcatca tttgcagcat actcaagcca tttttcagcc agctcgggct 2951161 cttttgtata tttcgaggca acccagccct tcccgccagc aaaaggggcg tattcttctc 2951221 catttggcaa tgtcggaatg ggagccgctc cgtagttcaa tttagcctct ttatagttgg 2951281 cagctgacca aggaccgcca atgatcgcag ccgctttgcc ttctaaaaac atctgctgaa 2951341 taaagtcgtc tgcgcttgaa ttgtcttgca ttcctttcgg ccaatatgtc tcaaaccatt 2951401 tctccgcata tttcaccgct tctacagccc ctttattgtt caggccgatg tccccggaat 2951461 ctgtgccgtt ttttccaaac acatatccgc cgtatccagc caataagccg tacgacatat 2951521 aaaagtcagt ccattttgct aaaaatccgg ttgattttcc tttttccgaa gcaaacgcga 2951581 atcgaggatc ttccgttaac ttttcaaggt ctttaaatgt ttttggcgct gtttttaaaa 2951641 gatctttgtt gtaatacaaa ataagtgtct caatgactag cggcattccg tacactttgc 2951701 cgtcaactgt cacctgctgc atttctttat caccaaagct ttttgtgtta gatggcttaa 2951761 tatcaagtaa atgtccttgt tgtcccaaac cgccgatccg gtcatatgca gcaagcataa 2951821 catcaggcgc attacccgcc gggccatcaa gaggaagcgc ttctaactgt tcgaacattt 2951881 gcttttcaac aatttttact gtgacatcat tttctttttc gaactttgtt tttatgcttt 2951941 caatgtattc tttatacgtt tcttcgacag acacagtcag cacctttttg ccatcagagc 2952001 ttgctggatt ttttgaactt gagcaggcgg caaggccgat tgccaggaat gatgccgcca 2952061 atatggcgaa cccctttttt aaaagaacca tctcttttcc tccttctatt tacgaaacta 2952121 taacaattgt attgtcctat agaaagcggt tacaacaact ttcgatttgt taccgataac 2952181 agaatgttat acaggggcgg cagcactcaa aatcaaaaat tctcccggct gaacggcaat 2952241 gacatcgtga tgctgtagcg gctgctctgt ccatgcatca cagattttct tattcctatc 2952301 aatattcaac tctcgtaaac tgacgtgttg aaccacattc ccttgattaa agaaataaat 2952361 cagtattttt tcatcaagag tccgcgaaaa gctaatgaaa tcatttttgt cgtccagcag 2952421 attccactca agatgtcctt cagtcaataa agtgttttcc tgcttgcgta aagcaattaa 2952481 ccgtttcata aattgcagca tgtcttggtt ttgcttctct ttttcccaaa ccatacattt 2952541 ccggcataat ggatcatttt cgccgttcag cccgatttcc gttccgtaat aaatgcatgg 2952601 tgagcctgtc tgggcaaaca taaaggccag caacgcgcgt gctttcttct catcattgcg 2952661 gcatctggtc aaaaggcgct ttgtatcatg gctatccagt aaattaaaca tcacctcatt 2952721 ggcctgcttc attccattca tcaaatgtgc attgacacgg tgagccatac gtgaagctga 2952781 gatcgtctgg tcagcaaagt attcaatcat aggctctgta aaagggtaat tcatcgccgc 2952841 atgaaattca tcccctctaa gccagggttc ggcagaatgc cagatctcac ctaaaatata 2952901 aacatcaggc ttttcagtag atacagcctg cctaaatgtc ttccaaaaaa cgtgatccac 2952961 ttcatttgcg acatccaaac gccagccgtc aatgtcaaat tcgcgaatcc agtacaaagc 2953021 aatatcaagc aaatatttct gcacctcggg attagccgtg tttagcttcg gcatatcagc 2953081 tgtaaaagca aatctgtcat aattgtcgtc tgtgacggga aaagagtgaa tatggaacca 2953141 gtccttatag cgggattgat ctccgttttt gacgacatcc tgccattgcg gagacgcgct 2953201 tcctatatgg ttaaaaaccg catcaagcat aattctcatc ccccgctgat gcagctggct 2953261 gaccaatgta cgaaaaagct caggatcccc gaaatgcgga tcaatagaaa agtaatccag 2953321 cgtgtcgtat ttatgattag aaggcgcgga aaagatcggt gtcagataaa tgccgttcac 2953381 ccctaaatcc tctaaataat caagcttgtc aacaattcct tgtaaatccc ctccaaaaaa 2953441 atcattgacg tccgggtcct tgctccccca cggcaatgca ttcttcggtg acaagtcttc 2953501 tcttccattt gcaaaacgct ccggaaaaat ttgataccaa accgttgact tgacccattc 2953561 aggcgcttga aatgtatcag cctcgtgaac aaacggaaat ttaaagtaat aatgaatcgt 2953621 ttccagtgtt ttttcgttat aagggcatac acccgaactt ccgaaaaaga tgtcttcatg 2953681 atcgtctgtt acaacaaacg catattgtaa acgcctaaat ggcggcacca cttcagcaaa 2953741 ccaatagtca tgcatttctg tagcagcaat tttcctcatc ggctgctcgt ttgccgacca 2953801 tttgccgtcg ttgtactcat agggatcacc ccaaatgaat cgaatgtgat ctgcatcacc 2953861 ttttttcgtc cgaatcttga tatgcacagt ccgcccatca taagaataag catctgtgct 2953921 gaatggctgg tgatgaatcg ctgcatattc catcatgttt ccccctttga tttccgtttt 2953981 attgaagccg gctcatagtt tgaaagtatc atgatgaaat tgtgggaaca atccttttca 2954041 ccctgttacc gataacagaa taaggcgctt acagcgttga ttctcgtaca attaactctg 2954101 gttcaaaaaa tagacttcct tgtgcagcgc cgtcttcatt catttttttc agcaacattt 2954161 tcgcacaggc ttcccccatt tcaacaacag gctgtctgac cgtagtcaag cgcggcgagg 2954221 agatgcgatc aagaaacaca ccgtcattcc cggtaaccgc aacgtcttct ggaattcgct 2954281 ttccaaggga ttgcgccgca cgaatgacgc cgagcgcgat tcgatcagat gcgcagacaa 2954341 atgcggcctg attgtccatg gatttcagca gttctcttgc aaggcattca cttttcttag 2954401 aactgttgtc gatccgaaac atattcgatt ttttaaagct tttattcatc gcccgtatat 2954461 acccctgttc tcttgcacgt tcgaaaggct catctaaatc aatgccaaaa aagacaactt 2954521 cccgctcccc cagccccata acatggcggg ttgccataaa agtgcctttc tcgttattca 2954581 catcgataaa gtcatagccc atttcatttt gtccaaatac gacgagcggc ttctcaaaag 2954641 cttttattac accttcaaaa tcgttctttc tcaagccggt ggcaataatg ccgtcacatt 2954701 ggccaatatt aagagaattt cttgtcacaa gctggagagc atagtgattg cgatccagct 2954761 ccctgctgat tcctgtcagc aggttcatgt aatatggttc tgtcgtatcc atttcctcaa 2954821 gtatcaatag tttcacaacc tgtgttctgt tttgcacgag cgctctcgcc gcataattag 2954881 ggatgtaatt cagctctttc atcgcagaat gaacaagctt tttcaattca tccgtcaccg 2954941 tctcagggtg attgatcact cgtgataccg tcattttcga aacatttgct tttttcgcca 2955001 catctgacaa tgttgccatt ttcatcccct ccttatctgt gcttattatc caaactagtg 2955061 ataaagtcct ctattactgc taaatatacg atgcaggcca aagagaaata aaaaagagat 2955121 ttcccttaag gaaacctcac tttgttaaaa acactcgatt tttcatggat tcatacgcta 2955181 ggtggcagac tcattctctc cacttccatc agaaaatctc ttttttaaat ttctgtccac 2955241 tttttttcta aaatcggata agaataattt tgcatttgct caattaactc atccggccgt 2955301 gacgagctgt gaatcagttt taggtgcgat tcgttagaaa acccttcttg aatgctgtat 2955361 ttcaccattt tcatcattgg ttcaaaatat ccgtttacat tgtacagtcc aattggcttt 2955421 tggtggatgc cgatctgtgc ccagcacagc acttcaaata attcttcata tgtaccgaag 2955481 ccgcccggca tcgagataaa gccgtccgcc agctcgctca ttttagcctt tcgttcatgc 2955541 atcccgttta cttcaatcag ctcagtcaga ttctgatgga caacctcccc gctgaacaaa 2955601 ccgctcggca tgaccccgat tgcagttccg ccgttttcca taatcgcgtc agcaatcgtg 2955661 cccatcaagc ctacgcggga gcccccatag acaaggccga ttccctgctc agccatatac 2955721 acgccaagct ctgccgcttt tcttttatac gcttcatttc ccccagggtt tgatcccgca 2955781 aatacacaaa tggttttcat cttgtcatct ccgcatctat atatcgtgtt aaacattcaa 2955841 aaacacacta tatattgtcc catcttcatg tgataatatc aatatgaaat acataaagaa 2955901 tgcaggagtg atgaggttgc agctggctga tgcagaaaaa tggatgaaag agttttacga 2955961 aaaaagaggc tggacagaat acggaccttt tattcgcgtc ggctttttaa tggaggaagc 2956021 cggagaactg gcccgggctg tcagggcgta tgaaatcggc agagaccggc cggatgagaa 2956081 agaatcgtca cgcgctgagc aaaaacaaga attgattgaa gaaatgggag atgtcatcgg 2956141 aaatatcgcc attcttgctg atatgtatgg tgtctcttta gaagacgtca tgaaggccca 2956201 ccaagaaaaa ctgacaaaac gatttgagca tgcataaaaa agcggccgcg atggccgctt 2956261 tttttaacct gtgatttcat catggtgatc aaagaaatgc tgctttccta ttttgtgaaa 2956321 aaggcctgtt ttatgcagta gctccttcgg ctgcgattgc aatcctacaa tcatcagctt 2956381 tccattgtgg cgtttaattc gattcataat gttcccaagc accgcttcag ctgacgtatc 2956441 catatagtgc accttattca tgagcagaat aagggttttc ggttttttct gtacatgctc 2956501 cagcaatgac gattcaaggg aatcaattga tccgaaaaac agcggccctt ctatggcata 2956561 catgctgaca gatggatctt ctctcttcgc cagaacagga tgcgtttcct gattgtggat 2956621 gcgggtcgct tcgctcattc ttctgataaa gaacacgaat gcaagcagca atccggttgc 2956681 cacaccgatg attaagtcaa acagaaccgt aagggcgaag gtcgccgcca aaataaagga 2956741 atcagcattt ttcagtctca gcatgtttgc gacttccttg cgctcactca tattccatgc 2956801 gaccaccatg agaatcggtg ccatactggc gagcggcaca tgggacgcat aaggcgcaaa 2956861 tacaagcagg acaaggagaa cgactacgcc gtgaacgacg ccggaaactg gggaaaccgc 2956921 tccgtttttt atattggtcg ccgttctcgc aatcgctcct gtagccggga ttccgccaaa 2956981 caggggcgct gccatattcg caatcccctg gccgacaagc tccttgttgc tgtcatgctt 2957041 tgagcccttc atgttatcag cgaccattgc ggacaaaatc gactcaagtc ctccaagaag 2957101 cgcgatgaca agcgcagccg gaaacagcat aaccatttta tccaaagtaa gctcaggaaa 2957161 ctgaaattcc ggcaaatggc gggggatttc tccataagtt gacccgatcg ttgccatgcg 2957221 gtcagggaaa aagacaaccg cgaccactgt ggaaataaga agcgccaaca aagcgcccgg 2957281 cactttaggc atcaccttgg cggatacaag caaaatgacg agcccgatca cagctgtcaa 2957341 aatggcatac acgttaaagg tgccgagctg ctgcacaatt tcaaacatgt tgtgatgaaa 2957401 gttctcatgt ttttcaacat ttctcaatcc gagaaaatta gcgatttgtt ccgtaaagat 2957461 cagcacggca attccggctg taaaaccgac gataacgggt ttgggcacga atttcattat 2957521 ttttccgagc ttaaacagcc caaacagtac cagcatcact cctgccataa accccgcaat 2957581 cagcagattt tccaagccgt actgcatgat aatgccgaat aaaatcggga caaaggcgcc 2957641 cgtcggaccg ccaatctgat attttgatcc tccaaacaaa gaaatacaaa tccctgctat 2957701 aacaacagtg tatagcccat attcaggctc gactcccgag gcaatggcaa acgccattcc 2957761 taaaggaatt gccacgacac ctactacgat acctgcaatc aagtctttct gaaatttctg 2957821 caaattgtat cccttgaatc tccctgagaa tcgcatattt tgttataacc tcccttatga 2957881 gtgattgttt ataagctcag tttcataacc gttaatgacc acatcaagtt ttcctgtttc 2957941 agggtgaatg acaagcccgt gaaccggcac ttttttcgga agcagcggat ggttcttaat 2958001 catgttcaca ctgtgggaaa cgctttcttc cacgctgtga aaaccagtca gccacgtttt 2958061 caaatcgagt ccggcactcg tcagcaaatt caggcagcta tcctccaccc cgcgttcctt 2958121 tgctttctca agaatcgagg acgcattcag ccctgacatt ccgcattcat gatggccgac 2958181 aatgcatacc tcttcagcct gcaattcata aatcgcgacc agtatgcttc gcatcacgct 2958241 tccaaatggg tgagaaacga tggctcccgc gttttttaca attttagcat caccgttttt 2958301 aagccccatt gcttgcggaa gaagttctgt aagccttgta tccatacagg tgacaatgac 2958361 gagctttttc gaaggaaact ttgtcgtttt gtacggttca tacttcttct cactgacaaa 2958421 ccgctgattg tgttccaaaa ttgatgttaa agaaaccatt tgattcatct cccatccata 2958481 tgattttgca agccttctta cccagcttac agtaaggaat tatagcatag gaataagcca 2958541 agaaaaggtt ttcaaaaaaa gacactataa ttggactgta gaatcaaaac ataaacattt 2958601 atatctttca aagataataa aatttatatt taatgcatcc tataatccgg ctgcagttcg 2958661 tatatcgatg atttgtctga caaaaaatat gggtgaattc tgataattaa aaaacttttt 2958721 taagcagatt tagctgttcg atcttcattt taagttcaaa agaaccagaa attaaaaaaa 2958781 cgcagctata tttttaacat ctatttattt tcgatataat gaattagaca acagccataa 2958841 agggggagcc ttgttgaaac catttgtatt tatcacaaaa ccgattcctg aagagattga 2958901 agcattcatc ggtgaacatt gccgttatga agtatggcag gaggatacgc ttccgagtga 2958961 cgtgctattt gaaaaattaa aagaagcgga ggggctttta acatcaggga cgtccggacc 2959021 gtcaatcaat cgtgagttgc tggaacacgc gcctaagctc aaagtggtca gcaaccaatc 2959081 agtaggctac gataacttcg atatagaagc aatgaaagaa agaggagtcg tcgggactca 2959141 tacaccttat acactggatg acacagttgc agatctggct ttttcactga ttctgtcttc 2959201 cgccagacgt gttgccgaac tggaccgttt tgtcagagca ggaaaatggg gaaccgtgga 2959261 agaggaagcg cttttcggaa ttgatgttca tcatcaaacg ttaggcatta tcggcatggg 2959321 cagaattgga gaacaagcag cgagacgcgc caaatttggt tttgatatgg aagtgcttta 2959381 tcataaccga catcgcaaac aagaaacaga agacagcatc ggcgttaagt atgcagagct 2959441 tgatacattg ctggagcaat ctgattttat tcttctcatt acgccgctga ctgatgaaac 2959501 ctatcacatg ataggagaac gcgaatttaa gttgatgaag aattcagcaa ttttcgtcaa 2959561 tatttcccgg ggaaagacag ttgatgaaaa agcactgatt cgcgctcttc aggaaggctg 2959621 gatcagggga gccggcttag atgtatacga aaaagagcct gtcacccaag ataatccgct 2959681 cctgcagctg gataatgtca cgctgcttcc tcatatcggt tcagcaacag ctaaagtgcg 2959741 cttcaacatg tgcaaacagg ccgccgaaaa tatgctcgca gcgatccaag ggcaaacacc 2959801 gaaaaatctt acaagagaat ttcaataaat caaaaatccg gtctgataac agaccggatt 2959861 tcatattaca tacgctgaag aacagcacgc ttataaatat gacgggtgac gatataataa 2959921 agagcctgga atacaaaata aatgaagatg acaattacgg cctcaagaaa taaattggaa 2959981 ttcagcatat tacttaacgc tgcatacgca aagcccgcgt gaatcgtacc tgcgataaat 2960041 gggatgaaga ataaaaatcc tatttgcttt ccaaggatcg agtgaatctc tttgtccgta 2960101 acccctatcc tctttaacgc taacacctgc actcccgtat cttctatttc cgtaaacatc 2960161 cgcaaataca gcatgcttcc ttgcacgata aaaaacagca cgctgacaaa cagaccaata 2960221 aacagcatta atgcaactcc ctgcttcaca atttgataac taggagcacg tgtttgaaaa 2960281 tcagatgtat gttctttcgg caccatgttt tcaagctttt cagagacatc caccgtctcc 2960341 tgccaatgct caagctcata acctaccatt ctcatctgtt ccttcagcgg cacatcctgt 2960401 gacagactgt caaagctctt ttcgctgaca accaataaac ggctgactcc atcgacagac 2960461 atcaatatcc ctttgttttg ctgctttttc atgacatagg aaagggtttt tcctgacttc 2960521 atatgaaatg ctgctgtttc cccttctcca aatgtgtctt tcaccatcat ttgaaaagaa 2960581 acattaataa atgcttcatt ttcttgtaaa tgaataactg ggaacccttt ttcctttgcg 2960641 acttgattat agactttttc tgaaatcagc aaagcttcag cttccatctt cttatttcca 2960701 tacggcaagt ctgactgaaa agtgacagga atccctgtgg catccacctt atacgtgata 2960761 acagcatgag cttttttcaa tgtattctca gccgtctcag gcttcatgac ctgaaagcgg 2960821 gaagcatcct tttccaccca ggaaacagac tgaggaatgc tttgctcctc ctgcctttgt 2960881 aaatcggaat aaaacatata gatgacacct gtagctgtta gtatgaccgc tgtaatgaca 2960941 gaggttaaaa acagcatgcg tgcatgatcc ttcagcctga atatcatgtt ggaacgcaca 2961001 atgatatttg tgcctttgta gaagctgtgt ttctttcggt acagcatgcg gaaaaatgcc 2961061 acactgcttt gggtaaaaaa gaaatacgtg ccaattaaca ctaaaatcaa aattggaaaa 2961121 acccgaaaca tcatgtcaat tgcattggct gttgcagata gataataacc gctgccaaga 2961181 catagcaaag acaatacagt gagccatttc gaataaactg gcaaactttt cggctttttg 2961241 gctgatttaa tcagttcaat gatttccagc ttccgaatcc gtcccagtga taaaatgagc 2961301 agcgtctgaa acaggatgag aaagccggca attgtcatca caaacgcttt cggcacaatg 2961361 gcaaacgaaa tcggcacctt cacgctgagc atccatgtca tgatcataaa aaacagtttt 2961421 gaaaataaca ggcctgctcc aatgccggcc gcaatcgccg caagagaaat aagtgactgc 2961481 tcataataaa tcatcttgcg aagctgctgc tttgatgtgc caaacagtgt cagcagccca 2961541 aactctttct ttcttgcctg caaaaacgct gaattggaat atgtgatgaa aaatatacaa 2961601 aacacaatga tgacgacaag agctgcgctc aagcatgttt tgacaaggct tcctccatat 2961661 atattgtctt cattgacatc aggatgaaaa ataaatgatg tgaagacaaa aaacaccgaa 2961721 acggcaaaca cacagcttaa aaagtaggcc acataccgtt gcagattccc aagaatgttt 2961781 ttacgggcga tagttctcaa attcatgaaa atcgcctccc aacacactca aggtatccaa 2961841 tatactttga taaaacacct gcctgtttgt tcctctgtga atctctgaaa agaaacgtcc 2961901 gtctttaata aaaacaatcc gtttacagaa acttgctgct gtggcatcat gcgtaaccaa 2961961 caaaatcgtc gcttcctttt cctcattcag ctgagccagt gtgttcatca cttgctttgc 2962021 cgattttgag tcgaggtttc ctgtcggttc atcggcaaga atgagcgccg gattgtgaat 2962081 aatcgctctg gcacaagctg cccgctgctg ctgtccgccc gacacctcat atgtgcggtg 2962141 atcgagaata tgctttattt gcagcgtatc cgccagttca tccaatcgag cttccatttc 2962201 tctcagcttt accttatcca atgcgagcgg caagagaata ttttcacgaa tcgtcagcgt 2962261 atcaagcaga ttaaaatcct gaaagacgaa gccgagttct cttctgcgaa acaaagccag 2962321 ctcttggtcc tttaacgttt tcggctgaat gccgttgatc atcatctcgc cctgggtcgg 2962381 cttatcaatg gtagccagca aattcaaaag cgtggttttt ccgcttcccg acggccccat 2962441 aatcccgaca aattctcctt ttgacacact gagatcaaag gcgctgagcg cttggtatga 2962501 tattgttcct ttatttgaat agtatgtttt cgataggttc gttgtttgca acacgttcat 2962561 gttctgctcc tcctttttct ttattataaa aaggaagtca gcatcctccc atcgaacttt 2962621 cttgcaattc cgctccccaa tcttacaatg ctgtcacatt cacgagggtg tcacttgaaa 2962681 acacgatggt catcacagtg ccagcccctt cttttgattc cgcatacagc ttatggccga 2962741 gacggctgca cacctgtttt gctaaataaa ggcccattcc agttgcctct ttcatggttc 2962801 gtccgttttc tccggtaaaa aacgcgtcaa aaatccgcgg cagatcctgc ggcggtatgc 2962861 cgattccttc gtcggcaacc gacaagcgcg tctcatgtcc ctgtgtttca atccggattg 2962921 taatagggtc tcccacacct tgctttgaat attttaaggc gttgaaaagg atttgctcaa 2962981 caacaaagga aagccacttt tgatcactgg aaatctgaac ggcatttggc ggcacatgta 2963041 atgttggaaa aaggcgccgc ttgataaact gacgtttttc ctgattgatc agtgaacgaa 2963101 ccatttctgc caaatcaaag gtttgcggct ttacatcaaa tgcaaattcc tccagccggg 2963161 ccgtttgcag catcatatca agaccgtggc gaaatctctc attctcatcc tccagctcct 2963221 ctaaaaacgt cggaaaagag gatgaggttc cgttttttcc ttcctgaatc attaaggata 2963281 tgacagatac cggtgttttc atatggtgga cccattggtt ggtgaaggtg taatgctgtt 2963341 tttgctgatt gatatattgt gagagcctgc tttcgtattg ctgcccgagt gcgttgatca 2963401 tcttcgtcca aagcgcttgc tctcctgttc ttggctttct ggctttcaaa gactgtccga 2963461 tgtcattcga agaagaggct tgttctgcaa gctttttaac atatgtgaga aaggaaaatt 2963521 gccgaacata atcagcagca aaacctgcgg ctaaaagagt accgggcaaa atccatatgt 2963581 acatcatatt ttctttggaa ggttctgcgc cgctctctac aatgcttaaa tacgcaatca 2963641 gcatggcgga ccctatccct aataatgaaa atagaataat ggctaagcgg tcgatgagat 2963701 aagtctttaa cattccgctt catccttccg attgacttga aattgataac cttgtcctct 2963761 gattgtggaa atgcaatctg tcagtcctgc attctccagt tttctccgca gccgattgac 2963821 attgaccgtt aacgtattgt catcgacaaa atcaacgtca tcccataacg cctccaatag 2963881 ttcatcacga gagacaattt ttttatgctc cctcacaaaa atcgagagaa gctggaattc 2963941 tttttgggaa aacaaaatcc ggacgctgtt ccattcggcc tcattctgat caggataaat 2964001 cgtcagcccg ccaagctcca ctattctaga ttcctgcggc aaagagggcg aatattcacc 2964061 atatgtgcgg cgcaggacgc ttttgatttt ggccatcact acctctagat ggaacggctt 2964121 tgtgatataa tcatcgccgc cattttcaat cgccattacc tgattcagct catcggtccg 2964181 tgccgatata aagataatcg gcgcattgga aatggtacgg atttgcctgc accaataaaa 2964241 cccgtcaaaa aaaggcaggt tgatatcaag cagcacaaga tcaggcttca tttctgcaaa 2964301 ttccaatttt atatcattca gctgttcagc aattttcact tcatatccgt atttttgaag 2964361 atgaccgccc agcaaagaag caatccgctc atcatcttcc acaagcaaaa tccgatacac 2964421 gttgatcccc cttatatgta catcacgatg atttttctag aagattccaa aattattata 2964481 gcatgtgcgg aatagtaaat cggtcttttt ctttttgtta tgatagaatg ataaaggtaa 2964541 aattttcata ataggcaggt gtcgtgatga agaaaatcat gctgtttctg gcaatgacgt 2964601 caattctttc agcatgtcag cccaactata ccgggaaata catagaaatt ggggatacac 2964661 taactgacta taccaaagag tgctttaaag agaatgaaat tccttataaa tacgaaaagg 2964721 gaaaactgta tatcccagaa gacgcatttg atacagcaat ctacacttgt tcataagaaa 2964781 aagcttgcag ataacctgca agcttttcac gttacaaaaa atgagtattt aatttctctt 2964841 caaatcctga agggccgatg tcgctttttt gaatgttacc gccgttttca taaatcgtaa 2964901 aatggcgctc tgacatgacc atccttccgc tcggcgtcag ctttgaggca agcagggatt 2964961 tgttaaaagg agatttttca tgagagtgaa tgatgtcctt catgttatct aaatcaccga 2965021 gatcactctc ttcaagggta aaggcgtacc caatttgcca gccttctcct ttgtccatca 2965081 gcagaacata gctgcccttt tctgtctctt cctttttgat tcggaatgac ccgactggtg 2965141 actgtaccgt ttctccggaa agcggtatcg gctggagcgc caggttgatg ccgaagccga 2965201 tatcaacgag gtaatcgccg ttttccgcag acagccatac agcagcatgc gtcccttcta 2965261 gtgcccatcc ctcttgatcg cctgcataaa ccgttcctcg aatgagcttc acatgaaacc 2965321 cggcctcacg caagacaaaa taaaggaaac catttagatc gtagcatagg ccgccgtgct 2965381 gatctttgag cagacgtcgc catagctctt cttttgtgat cttataattc tcttttgcaa 2965441 gtacggcacg gttttcgaat ggaaaacggt atgccattgc tttaagaaaa aggggaagat 2965501 cgccgaagct gacatggtct ttctcccagc cgattttctg aaagcagtct tttagaaagt 2965561 cactcatttt tatcacctaa acttcttctt gaacgtaagc agccagcttc tccagcgcct 2965621 cttgttcatc ttctccctgg gcaatcaagg taacctcagt gcctgtgctt accgcaaggc 2965681 tcatcagccc catgatgctt ttggcgttta cttttttccc atccttctca agaaacacat 2965741 ctgacgtaaa ccggtttgct tcttgtacaa acaaagcagc aggacgtgct tgcagtcctg 2965801 tctttaatcg aacttccact ttctgttgaa ccataagatc tccccttttc tttacggtta 2965861 ttttaaagtg acggtttgcc ctgtccgcag ctgttctgcg atttcgtcaa gttttctcag 2965921 cctgtgattg atccctgatt tgctgatttt cccgcttgct accatttccc ctagctcttt 2965981 cagcgtcact tcctgataat caatccgcag ctgcgcaatt tcccgaagtt tttcaggcag 2966041 cgcctccagg ccgattcttt catcgatgta tttaatattt tccacctgtc tcagcgatgc 2966101 gccgatcgtt ttgtttaagt tggctgtttc acaattgacg aggcggttga ccgaatttct 2966161 catgtcccga acgattctga catcctcaaa tcgcagaagc gaattgtgag cgccaattac 2966221 gttcagaaac tctgtaatct tttcagcctc ttttaaatag gtaatatagc cttttttccg 2966281 ttcaagcgtt ttgctgttta actgaaactc atttaacagg tcacataatg aatcgttatg 2966341 ctccttataa agagagaaga tttctaaatg atacgaggag gtttccgggt tattgaccga 2966401 acctcctgcc aaaaatgctc ctctcatata agaacgcttg cagcatctct ttttgaccag 2966461 ctctttcgaa atacttcgtt caaacacaaa attctccccg agtattttta aatcctctaa 2966521 gatcgctttt gcattttctg aaaaacgcac aatatagacg ttattctttt tcagccgcat 2966581 tttctttctg accagcagct cgaccgacac atcatattgt tttttcagca atgtatagat 2966641 gcggcgggca atcgccgcgt tttcggtttg aacatcgagt acgagatggc ggtttgtaaa 2966701 tgataaagct ccattcatcc gaatgagtgc agacagctcg gcattaatgc agcagtcctt 2966761 cacttccaga ttcgttaatt ctttttttgt ttctgatgca aatgacatat agccacctca 2966821 tttcaaggct tcattctttc agtaaatcaa caagaagaga ggccacttta tgtgtatcgt 2966881 gacgtattac gtcattttta tacgttacaa tttgatctct gatgacttca agccccatcg 2966941 ctttcagctc ttcgatatca aaatcaacag gacgcgccga ttccatttcg tacttacgtt 2967001 ttatttcgtc gggaatgtct tcactgttca ctaatatcgt atcaataaaa ccacagccca 2967061 tatgctgatt gagcgctttc acatgatcag cagcggtgta atggagcgtt tcgccgggct 2967121 gagtcatcac gttgcaaatg tatacttttt tcgccggcgc ctttatcact tcttccccga 2967181 tttttgggac gagcaaattg ggaagaatgc tggtatagag gcttcccggg ccgataataa 2967241 tcaaatccgc ttccctgatt acgtctattg tttccggcag cggatcaatc tgttcaggcg 2967301 tgagaaaaac acgcttaatg cgctgtccgt attctgggat cgttgactcg cctgagacca 2967361 cgcggccatc ttccatctca gcatgcaaaa cgacactggc attggcagcc ggcaaaacct 2967421 ttcctcttac attcagcacc ttgctcattt ctgtgacagc gtgaaaaaaa tcaccggtta 2967481 tatttgtcat cgctgccaaa atcaaattcc cgagagaatg gcctgttaag tcattccctt 2967541 tattgaagcg gtgctgaaaa agatcttcaa caagcggctc cacatcggat aaagcggcaa 2967601 gcacatttct gatgtctccg ggaggcggaa ttttcagttc attccgcaga cggccagagc 2967661 tccccccatc atcggcaact gttacaatgg ccgtgatgtc aacgggttta tgctttaggc 2967721 cccgaagcaa tacagaaaga cctgtaccgc cgccaaagat tgcgattttc ggcttttgtc 2967781 ccatcttatt tccggcttct cttttcaatg tcccggtgag taacatgagt atagtaatcc 2967841 tttttgaaat aatcagctaa attctcggct aatgtcacag agcggtgctg gccccctgtg 2967901 cagccgatcg caatgacaac ctggcttttt ccttctcttt tgtaagatgg aagcataaag 2967961 ctcagcagat caattaattt ctcattgaac ttttgcgttt cattccactt catgacgtaa 2968021 gaggaaacct ctttatcctt gccagtcagc ggccgcatgc tttcgatata gtacggattc 2968081 ggcaaaaatc tgacatcaaa gacgagatct gcatcaattg gaataccgta tttaaaacca 2968141 aatgacatca catttacggt aaatgtctct ccttggtttg tcgcaaagtg cttcacgatt 2968201 ttttcacgca aatcacgcgg cttcatgtca gacgtatcgt aaatgatttg agagcggcct 2968261 tttaattcct caagcagctc tcgttctagc gcgatgcctt caagcggcag gccagtcgct 2968321 gccagcggat gcgagcgtct cgtttcttta tatcttgtga cgagaatgga atccttcgcg 2968381 tccaggaata aaattcgcgg tgtgatccac ggattttcgg ccatttcatc cagcgcttca 2968441 atcagccggt caaaaaattc gcggccgcgc aaatccatca cgagcgcaac tttgctcatt 2968501 ttcgaatttg attccttcat cagctctaaa aacttcggaa gcaatgaagg cggaagatta 2968561 tcgacgcaga aatagccgag atcttcaaag ctttggatcg cgacagtttt ccccgctccc 2968621 gacattccag ttataatgac aagctgaata tcatgtgatt cactaacact catctttctc 2968681 ccccctgact tgtctttcta tttgatgtgc tgcgggtcta aacgataact gagcagctca 2968741 aattccggtg tatacgtaaa tgtgccgtgc agcagccctt gtcccttcat cataaaatca 2968801 aggatatggc cgtctccagg ggccataggc aggttctgaa tgtcattgac atcgtgccac 2968861 tgcagtttgc cttcctctga ttctgataca ttttgtcctg tatatgaatc agcgacaaac 2968921 gtaaacatca tccactcgga gacaatgtgg tcaccgtctt taataataaa ggtaaaaacg 2968981 ccttttaatt gaggatttat gatatagata ccagtctctt ctctgtactc tctgatgacg 2969041 gagtctctga ctgattctcc gctctccatc ttgcctcccg gcgcgaccca ccatccgcgt 2969101 ctcggctttt gaagcagaag aactttgtca tccgtctgaa gcacacaatt tgtcactctt 2969161 tgcaagtacg tcacctaacc ttcgtcctgt catcgtctct ttattatacc gcttcaagat 2969221 gcctcccaca atgaagagac attgacaatc ttttcttcta ttttacagca tattcattcc 2969281 ttaattcaga tgattttgct gtaactggaa ttctctttta tttatggaca aaaaaaggac 2969341 acggataact ggagaatccg tgccaaaaaa gtgtattcat tataaaaagg gggtcaatta 2969401 ctttattaat cataaccgaa aagcattaca catgtgttac agcggaatta aaacccagta 2969461 acgtaatgtg aaactcgtat gacagccctt tttattttaa ggttttcagc gtttcttgga 2969521 gctcttcgac ataatgttgt acgctttgtg ccgcaatgct tccgtctcct gtagccgtta 2969581 cgatttggcg cagtgatttt tcgcggatgt ctccggcagc gaaaatccct tcaaccttag 2969641 tttccatgcg gtcgtttgtt tcgatatagc cttcttcatt cgtaatgccc aggttttcaa 2969701 acggtttaga cagaggaagc atgccgatgt aaatgaatac gccgtctgtt ttgaattcac 2969761 tttcttcacc ggttaccgta tcgacaagcg ttacgttacc gactttgccg ttttcctcat 2969821 gaatttcctt cacagttttg ttccatagga agtcaacttt ttcattatca aatgctctcg 2969881 cttgaagaat actttgagca cggagtttat cacgtctgtg aacaatcgtt acttttgaag 2969941 cgaaacgagt cagatatacg ccttcttcaa ccgcggaatc tccgccgcca acaacgacaa 2970001 gttctttgcc tttaaagaaa gcgccgtcac atactgcaca ataagataca ccgcgtccgc 2970061 ccaattcttt ttcgccaggc acgccgattt ttttatattc cgcacctgca gcaatgatga 2970121 cagcacgggc tttatattcc tttgaaccag ctttgactac tttgtactct ttgccgtcaa 2970181 tgacctcttt aatatcgcca taagcgtatt cagcgccgaa ttttttcgcg tgttcaaaca 2970241 ttttgttaga aagctcaggc ccaaggatac tttcgaatcc aggatagttt tctacatctt 2970301 ccgtattggc catttgtccg ccaggaattc ctctttcaat cattaatgtc gataaattcg 2970361 ctcttgatgt gtatacagcg gccgtcatcc cagcagggcc cgcgccgatt ataatcacgt 2970421 cataaatttt ttcttctgac acactattca ctccttaaac catcttttca agtttgggct 2970481 ctttcttata agataagaat ccccatcaaa cgtattcctt acccatatcc tataaaatct 2970541 catggtgata cgctattttt ttgctcaaca cgattaaatg tattcgaaaa gggtatatgt 2970601 taataaagaa agagccttct gtttatagaa ggcccttgtc atatttatta ttgaacaaca 2970661 cgtcttacaa cacctttaaa tgctgctttc cagtaaggat tgctcataga gtcaacagat 2970721 acgccatgag atgtattgtc gtttaggaaa gtaccgtttc ctaagtagat tcctacgtgt 2970781 ccatttgttt tgtaagtgtc aaagaacaca aggtctccgc gtttcatttc agacgcgctg 2970841 acagcttgtc ctctgccaac taacgtatca gttgttgttc cgcctacagg tccaaggtta 2970901 acacctgcag aagcgtatgc ccagcgtacg aatgatgagc agtcaaaaat acggttgttg 2970961 atatcagact gagtgcgtcc gccgccaaac ttgtacggag attgtcctac aatgcttgaa 2971021 ccaacgctga tcgcgccttc aattccgcca gagttgctga taacagtgcc gcctgaattg 2971081 ctgtttgagc cgctgctctt cttagaagat gagccgtttg acgaactgtt tgatgaaccg 2971141 ttagaagaat tgtctgaaga attgtctgaa gaatcatcag atgagcttgc ttttgatgat 2971201 tcagttgtcg ccgtttgact gtcatctgtt tgtgtttcat cagatgcttt ttgtgcttct 2971261 tcctgctttt tgatcaaagc agccgctgct tcttgttctt ttttgatgcg tgcttgttca 2971321 gcttcagtat ttgctttttg atttgcaagt tcagacgcct ctgattttaa ttcagaaatc 2971381 gctttagccg ttttcttttg gcttgctttt gcttcgtcga aaagcttgtc tttttcatta 2971441 agctgtttat caaggtcttt ttgcattgtt tctaatttag ccaaggcagc ttgaacttct 2971501 ttcagcttgt cattcaaatc cgcttcagaa tcttcgagct tcgctttatc ctgctcttgc 2971561 tgtttgatta aatctttgtc tgcgtccaca atagatgaaa ccgcagtcgc acgagagata 2971621 aagtcaccaa agcttgttga tcctaaaaga acatctatgt atccttgaga tccgccgctt 2971681 tcctgtaaag aacgaacgcg ttttttcagg atttcattgc gtttttcgat gcgtgcttca 2971741 gtttctttaa tctctttttt cagttttttg atttcttctt ttgttttatc gttttcttct 2971801 tttttatctt caatcttgtt gcttgtatca agcgccttat cgttaatgtc tttcagttct 2971861 ttttcaatct ttgattgatt ttcctgaagc tcggttaatt ctttttcctt cgcttcaatg 2971921 ctggaagcaa cctcagattg cttgctttcg attttttgtt tcttttcatc taatgtttcc 2971981 gccgatgcag ttttacttgt aaatgggatc aaaaaactgc ttgtcccgat gacggaagcc 2972041 aaaccaagtg taattaaact ctttctcact ttttatatcc tcccttttac tgtgaacctg 2972101 tcctcatttg gaatcgtatt ttgaacatca agtttcgttc ctcatactct acgaggaatg 2972161 atggttgttt atggttaatt attctgtgca tctcttattc tggttgtata gcgtttattt 2972221 cacatcatat gtaaaaaaca ctaattcctt atgtacgaga atcattatac catcaagttt 2972281 cgacaaatta gcgataaatt ttattacatt tatgtttcaa acagatgtca agtcacacat 2972341 catttgtcat ttttcttaag cgtgtaaaaa aactgtcgat attattttct taatataatc 2972401 tatctaacaa aaaaagagtc gattaaataa atcaactctt taaaatttac tattctagaa 2972461 tatcatcaat atatttcata tatttcgtca aagttgccgg agagatgccg aatcgggccg 2972521 ctgtgtcttt tttcgtgtct tgcttgccat gggcttcttt ccaaatataa cagatggctg 2972581 ctgcccagcc tttctcattc ttcaacggag cagctgcacg aatttgctgg atgacatgaa 2972641 aaacccagca gctcatgact tctgttttca tctcttcttt ttcagcttgc tctaatagtt 2972701 tgaccgtttg ataagcgaaa agtgcatcct ctgaaacgtc agcagccgca gaatctccat 2972761 tcagaagcag ctttacaaaa tgagtttcaa aaggagcggt aattctcttt gagcgtatca 2972821 ccgcttcaag atgctctgtt tctccctttg tgctgctgat ataataggct gcgagtcgct 2972881 gctccacaga tgaaggaaga gcttccctcc gctcaatcca aggcgccggg cggtcttcgc 2972941 cgggatattg cgactcgact tttctccaga tcgtctcggc aaagtcggta tgtcccgtaa 2973001 aataagcaga gcaggaaagc cagtaaaaga aggtgtcgtc accctcaaag ccggttttat 2973061 ataatgattt gagccattta tatccgatct cgtagcggcc gacaagcgcc aaagtagcac 2973121 ccaatttata acgctgctcc aatagcatcg gatagacatt ggagagctga tcactcaatt 2973181 ccgccacttt ttcgtcttct ctttcataat agtagaaaac gagaagattg cataaggcgt 2973241 gaagatttcc ttcattatga gaaagcactt cataagcggt ttgcttcgct tttacaacgt 2973301 ttcctgaata gaaataggca agcgcgagat tgttgtatgc tgaccaaagc tccggatatt 2973361 cagttgtgat ttcctcaagc gccgcaaccg cttcagcaag ctggccgctt tccagcaatg 2973421 actttgcccg atcctgtttc accagcagtt catcctgatc atacaacgaa tcctcaatgc 2973481 cgtcgtctcc taaatcgagc aaatcaagca gactatcgtt ttcttcggcg aattcaccat 2973541 ccgggtccgc atcagaataa gcggccgctt ctttataagc ttcctggaag agccccagat 2973601 gggcaaagtt attcgcttta aagtaatggc actccggcat ttcggcctcc agatttgcca 2973661 tgatatagtc aagaagatcg ttcgactctt gatactggcc catttccgaa taaatgaccg 2973721 caagctgtga aagcatctct gaatcctccg gctccaaatg aaccgcgcgc tgaatcagtt 2973781 tgcttgcccg ttttagattg cgctctttat acgctttcaa gcctttatga aaaaaatatt 2973841 gtccatcttg aagcagctgg acaatttgtg cgtgattttt atgttcagaa gtgtgttttc 2973901 ccacaactac cctccgtttt atacaatatt accgtcagta gtataccata aatcgtaagc 2973961 ccctcaatag ttcaaaagga aggattggga aaatccctcc tcttttttat tggctgattc 2974021 gaccaaaatt tacccggctt tgttttctaa gtccgcattc attttcagct gctgttcagc 2974081 aaaatcccgg taaaggccat gggaagccat taactcatgg tgtgttccac gaccggtaat 2974141 ttcccctttt tcaacaaaca aaagctggtc cgcatctaca acggtagata ggcggtgagc 2974201 gataacaatc gttgtgcggc cctccatcag cacctccagc gcctgctgaa ctgatttttc 2974261 agattggctg tcgagacttg aggtagcttc atcgagcata agaatgcttg ggttacggag 2974321 aagcgctctc gcaatcgcga ttctttgcct ttgtccgcct gacagcataa tgccgcgttc 2974381 gcccacttct gtatcaaact gattcggcag ctcctttata aaattgagcg catatgccat 2974441 ctccgcggct ttttcgatct cagcatccgt cacatctcgt tctaacccgt agcaaatatt 2974501 ttctctgatt gtcccggaca ttaacgggct ttcctgtgat acatacccga tatgctccct 2974561 ccacgattca agcgagtaag tatcgaccgg ctcgtccccc agccgaatgg tccctgcagt 2974621 cggagaataa aagcgttcaa gcagcttaaa cagcgtcgtt tttcccccgc cgctcggacc 2974681 gacgatcgct gtcactttcc ctgcttcaat gacggcgctg acctctttta agatcagctg 2974741 atcaggctta tatccaaaag acacgcgatc aagctggata ggcagatgtg cattttcaat 2974801 ttgttttcct gtcactgtat cttcctcttc ctctgccaaa atctcaatca ttcgttctgt 2974861 tgcaccgatt gatttttgca gctgtgtgaa aaacgttgta atctggccca tcggcataat 2974921 aatttgaaac aaatataaaa taaaagccac gagcgctccg gctgtgagct cgcctgatga 2974981 gacctgcatg ccgccatatc cgatcactgc gacaagcgct gccattaaca cgagtgaaat 2975041 aagcgggccg acaagcgatt gaaccttggc ttcacgaacg ccaagcttaa ataatgagga 2975101 aatccccatc ttcccgcgcc catattcgac atcctccgca tttgaagcct taacaagtct 2975161 gatttccggg agaatttgat taagcaggcc tgtaaaacga gccgtttcat cttgcgtttc 2975221 ccgtgaaatg gagaacattt tccgtccaat cggcaccaaa ataagagcgg ccagcggaac 2975281 gaccactaac acaagcagtg tcagcttcca gttcataata aacaagattg tcaatgatcc 2975341 aatgacagaa atgatgcctg taataaatcc gctgatatgg gttgtaatca attctttgac 2975401 caccatcgta tcgttcgtta cacggctgac tgtttctccg gaagcatttg tatcgaaata 2975461 agagacaggc agcttaatta atttcttcca taataactcc cgcagcccgg aaatgatttt 2975521 ttgtccatta tagttaagcg cataggtggc ataagcgctt aaacccgcct gaacgaaaaa 2975581 caccagcgcg atcaaaccga tttgcgtgcc tgacagattt gacatagaaa aaccatcgac 2975641 aagctgcttc gttaataatg gaatgagcag gctgaccagc gtggttacta cactgagggc 2975701 aagcgcaaag gcgagctttc cataagaagg attggtccgt cttactaagg caaaaaaggg 2975761 tttcaattta cttttagatt tttgtttctt ggttggcata tattttcctc ctgtttcagc 2975821 gttcagaaag gtgaaaagtc atagcaaaag gatgattttt actctttctc aatcatatca 2975881 atggagaaag actttttcag tatatttttg ccgtgatcaa aataaaaatc tcccactcat 2975941 tgtttgaata ggagattttt gtgttagaca tctttcactg gcttcttttt tctgtaagtc 2976001 aatgttacat cctgctgtcg caggtcttct attatcattt tgtaccgatc aacttttgcg 2976061 gtatgttctt cttttatcat ctgaagggca gcttttcgtt tttcgctatt agactcaagc 2976121 tcttttttta ttttttttac aatcaaccct ttttgccctt tgatttcctc ttttaatgaa 2976181 gactcaaatt tctttgtcag gctgagaaag tcgttgatcg gttgattgag ggtgcccgct 2976241 ttccccttca tttcatcttg ggtaagaaac atataggtcg ttgatacaat ttctgtttca 2976301 ctttctgaaa ataaggaagt cactcttcat attcctccta agactgaaaa tcaaataact 2976361 gagaaatcat ttcttctttt tcaaacagct tttcaatact ctcgcggata tttttgataa 2976421 aatctctttt ttctgttgtc tgttttttta attcagcaac aattccatca tttgcaggaa 2976481 gcgcacctgt gtggaatgat tcatgaactg agattttctc caatttatcg aatgtgtggc 2976541 tgaaaccagc tgcaagccgg aattgaagat cgaaggcata atgcgaaggg ttttcttcca 2976601 tatgatgaat agccgtgatg atcgcctgct ttttgtctat gaagtcttca tcgatttcct 2976661 gactgtaaac cttctggtac ttagaaatcg catcttccat atcttcaacg attttcatac 2976721 cgttttgata gattctgaca gcggatgaga gattgacttg aatcgtttct cccgagccac 2976781 tcttccctgt aaaataaata tcggagcctt tatagctgaa gcctttttcc tttgacaagg 2976841 cgttgagcat ttgaacgatg ctgtggccgt cgacgataag ttttagtgcg tcttttgttt 2976901 ctgtgtcgag tgttttcaat gaggacagaa ttgattttac atagtccact atttcaccaa 2976961 cgtcttttaa agcttgcata aattggccat gttttagatg gtctatgaaa tgttcgtacc 2977021 gtgactctat gcctcgcata ctcgcattaa tattcgttaa ttcttttttg atgactttct 2977081 tttgcgtttc atcaatataa ccattttcag ctaactgatc tacgaccggt ccgctgtttc 2977141 tcaacaaggt atgaagaaaa cctaaaaacg acggcagttc ctcttttatt cggccataca 2977201 tttgcttaac atcatcaaaa tgctcatata ggacacttac tttctttaaa gcgccgtctg 2977261 tgtttttcac tttttcaatc aggtctatgt ctatcccgct ggctgccttt ataaaaccgt 2977321 tcaagccgtc tttttcatag tcatccttat atttttgaag gaatttttga attgacctca 2977381 catcttcgtc aggaacccca tccataatgt ttcggatgcc ttttacactt gtatttgtat 2977441 ctgccatctt cacatcaccg aatgtaataa aatcggcctt gccgctgact ccatacagcg 2977501 ggtcatcttt tgagatgcgc tgagtgatgt ttgttgttac gcctttgtct tcataatatt 2977561 tttggatttc tttttttaac ttttctggcg ggatggaatc tatatcttca tatttataac 2977621 taaatttcct aataacatat ctatataaac tttcatcagt ttcaagtaat tgatcaatat 2977681 tgacttgagc tccatttacc ccataaactt catcatattc tccatcaatc aattgcacca 2977741 taacttggtt attatttgca agtgaatgtc ctaaggcgaa tgtttttaaa tcctcagagt 2977801 tacctgctgc tttctttgct ttgttagtaa actcctttgt agcctcatac tgactatgat 2977861 caattcctaa aaaaagacca aaaaagttat atgaccaatc cttattatcg gcactacctt 2977921 ctgaaataat ctgaagctga tcaatatgtt ttttctcatc tattatatgg attgccgttc 2977981 catcgtaacc tgattctctg gtcgaacttt gtatacttgt attctgattt acaagttcat 2978041 tggaggtgta aatttcaatt ttcatattct caggaagatc gtggtgggtt tcctctttat 2978101 aaattctgcg tatatctgct tcgaaatcct tcttagcttt cttaacttca ctcgcaatag 2978161 ttgaggcaaa cttttgttta tagtcatatt ctaaatcaat taaccttaac tttacgttct 2978221 cattctcaaa tacattttta tttcccatct tatttctcct ttttatctat taaaaaggtg 2978281 atagaattaa ttaatttctc aactttattt ttagcctttt cttcatctaa ggagcatggt 2978341 tgattttcat ttttgcatcc aagggtaaag gcgtattcta ctcctaggtt atcttcctct 2978401 gtagacttaa catatccaaa ataactgtat gaataattat attttctatc aatatcgtca 2978461 aagatgtctt ttttcttggc agtgtaaata tccgttttct ttttgctgct ttttttgtat 2978521 tcgcctttat aatcattttt tccactaaca atatctagca ttgtcttagg ttcattcgca 2978581 aaactttctt ctttgtaata tgttacatgg ccatcaaaca ttacattggt gtctttatca 2978641 taactattaa atccaatact ttctttgttt ttcccggtta acgatgatct tcttgataga 2978701 tactttccat cctccggaaa caacatccta aaccctttca gcttagattc cagcaaataa 2978761 tatcctggtt cctcttcttt tgttgacacc atgtactctc tcgttttctc gtcctgaaac 2978821 gcaggtactt gaggcagatc cttgggatcc ccgctagctt tttattttta aaaaattgtc 2978881 acagtcatgt gccaaagtcc tctttacttt caattgtata gggactgtaa gcgttttaac 2978941 atagagtcaa agggaagcat cattctctga acatatttct taagtgcaga aaaaggatgg 2979001 aggccataat atgagtcaga aaacagacgc acctttagaa tcgtatgaag tgaacggcgc 2979061 aacaattgcc gtgctgccag aagaaataga cggcaaaatc tgttccaaaa ttattgaaaa 2979121 agattgcgtg ttttatgtaa acatgaagcc gctgcaaatt gtcgacagaa gctgccgatt 2979181 ttttggatca agctatgcgg gaagaaaagc aggaacttat gaagtgacaa aaatttcaca 2979241 caagccgccg atcatggtgg acccttcgaa ccaaatcttt ttattcccta cactttcttc 2979301 gacaagaccc caatgcggct ggatttccca tgtgcatgta aaagaattca aagcgactga 2979361 attcgacgat acggaagtga cgttttccaa tgggaaaacg atggagctgc cgatctctta 2979421 taattcgttc gagaaccagg tataccgaac agcgtggctc agaaccaaat tccaagacag 2979481 aatcgaccac cgcgtgccga aaagacagga atttatgctg tacccgaaag aagagcggac 2979541 gaagatgatt tatgatttta ttttgcgtga gctcggggaa cggtattaga aaaataggtg 2979601 tatttggaag agaacgaaag caaggaggag cagacgtttg aaccgatcag gcaagcatct 2979661 tatcagcagc attatcctgt atccccggcc cagcggagaa tgtatatcct caatcagctt 2979721 ggacaagcaa acacaagcta caacgtcccc gctgtacttc tgctggaggg agaagtagat 2979781 aaagaccggc ttgaaaacgc gattcagcaa ttaatcaacc ggcacgaaat cctccgggga 2979841 tccccgggta ccatgggccc gcggccgcct cgagaattca tcgatacgta gccggctagc 2979901 acccaatata aatctaaata cctattactt ttttcacaaa acaaaaagag ccgtatcatc 2979961 cggctcttta ctcttcaatc tcagaatggc gttttttcaa tacgtcaagc acatcatcca 2980021 gcggcaggga ttgttctctg agcaggacaa gcaggtgata cagcaggtct gccgcttccc 2980081 atttgagttc ctcatgatcc cggtttttcg cggcgatgat gacttcggat gcttcttctc 2980141 cgactttttt caaaatctta tcgacgcctt cacggaagag gtacgtggtg taagctcctt 2980201 caggcatttc cgcttggcgt tccgcgatca cccgctccag ttcgttcatg atgccgaatc 2980261 ggtccgcggc ctgttcttct gtttgttcct ttgtaaaaca gctgtagctg ccagtgtggc 2980321 atgccgggcc tgacggttct acgagtacga gcagcgcgtc ttgatcgcag tcataccgga 2980381 tacctttgac ggcttgcgtg ttccctgagg tttctccttt atgccataac gcttggcgtg 2980441 agcggctgta aaaccatgtt tccttcgttt ccagcgtttt ttcgtacgat tccttgttca 2980501 tatacgcaag tgtcagcact tctttgcttg ccgcatcctg cacgatagca ggaattaatc 2980561 cgtcctcgtt aaaacgcagt tcatctgcct gtttcatctc acattcaccc cgtactcttt 2980621 caagtatgat ttcacttctt taatcgatgt ttctttataa tgaaaaattg aggcggccag 2980681 cgcggcgtcg gcttctcctt ttgtaaaagc ctcaagcata tgctgtgcgt ttcccgcgcc 2980741 tcccgaagcg ataacaggga cggggacagc ttcggaaaca agctttgtca gcgtgtggtc 2980801 gaaacctttt ttctcaccgt cggagtccat gcttgtcagc aatatttctc ctgccccgcg 2980861 tttgacgcct tcttttgccc acgcggtgac ctcccaatct gttttctttc tgccgccgtg 2980921 cgtgtagacc ttatatgtgt cagattcttt gtcatacttg gcatcaatgg caagtacgat 2980981 gcattgagaa ccgaaaaact cggctccttc tgtaatcagc tcagggcgga gaacagctgc 2981041 cgtgttcacc gacactttgt ccgctccggc acgcagtatc gttttcatat cgctgagctg 2981101 attgatgccg ccgccgactg taaacggaat ggcaagcttc gcggcaacct gctccacaac 2981161 gtcaaccatc gtctttcgtc cttcgtgcga ggcggagata tcaagaaaaa caagttcatc 2981221 cgcaccttcc cggtcgtaca cttcggcgag ttcaactggg tcaccggcat ccttcaattc 2981281 gagaaattga attcctttga caacgcgtcc ttctttgaca tcaaggcatg ggataatccg 2981341 ttttgtgatc atttgcgctt caccctttca agcgcctcac tcagcgtaaa ctgattggta 2981401 tacagcgctt ttccgatgat cgctccagag acgccgtccg cctcattgcg ggcgagagct 2981461 tcgagatccg cgacggagct gactccgccg gaagcgatca ccgatttccc cgtttcctta 2981521 gcaagctcga ccgtgctttt aacattgggg cctgacagca ttccatctgt cgcgatgtca 2981581 gtaaaaataa agacttccgc accttcattg gctagctctt tgcccagttc agttgcctta 2981641 agggttgatg tttcaagcca tccctctgtt gaaacaaaac cgtttctcgc atccagtccg 2981701 attgcaattt tctcgccata ttgtttcagc atttttttga caaacggagg gttagaaact 2981761 gctgagcttc ccaggatcac ccgctcgact cctgctgata aatattcata gacgtcattt 2981821 tcagaacgga tcccaccgcc gatttcgact ttcaggttca gcttttgcgc aatctcaatc 2981881 acatggcggt cattcactct tttcccttct ttggccccgt cgagatcaac gagatggatc 2981941 cattcggcac cctctttctc aaataactca gccatgtcgt acggtgaatc gccatatatc 2982001 gtttccttat tataatcccc ttgaacaagg cgaacacatt tgccgtttct catatcaatt 2982061 gccggatata atgtaaaagc actcattttt tcaccttctg ttctgctgcc attttcgtaa 2982121 attgggttaa aatagacatt ccgaccgtgc tgcttttttc cggatgaaat tgggcgccga 2982181 agacgtttct ttttccgact acagcaggca ctcgtacacc ataatcggcg cttgccagaa 2982241 gcgcgttctc ctccatcccg tcaatgtaat aggaatgaac gaagtaagcg tagccttgtt 2982301 ctgttttagt cagcagcgga gattcattat gaaaagaaag acgattccag cccatatgcg 2982361 gaaccttcag cttgtttcct ttttcatctt ctgctttcag cctgactgct tttcctttta 2982421 acagcccgag tcctgaagcg gtgccgtttt cttcgctttc ttcaaataaa agctgcatgc 2982481 cgaggcagat cccgagaagc agccttccct ctgagaccat atcgtgaatc aattgatcaa 2982541 gcttcgtgta gcccaaattg tccatcgcgt ctccaaatga accgactccc ggcaaaatga 2982601 aagcatcagc ttctttcagc tcctccggct tttcagaaac aaaatacggc acgccgacac 2982661 gttcaagcgc ctttgagaca ctgtataaat tccccattcc gtaatctatc acgccgatca 2982721 tttacagcat ccctttcgtt gacggtattc ctttaactcg cggatcgatc gttgtcgctt 2982781 catcaagcgc acgtcccagt gctttaaaaa cggcttcaat catgtggtgg gtatttgttc 2982841 cataatgaac gatgacgtgc aggttcattc gagcttcgag cgccagcttc cacaaaaatt 2982901 catgtacaag ctccgtatcg aaagttccga ctttagcagc cgggaaatca gcgcgcattt 2982961 ctaagtgcgg ccggttgctt aaatcaatca caacttgagc aagtgcctca tccatcggca 2983021 caaacgccga tccgtagcgt ttgattcctt ttttatcgcc caacgcttcg agcagcgcct 2983081 gccctaagca gatgccgata tcttcagtcg tgtggtgatc atctatatca acatcgcctt 2983141 ttgcgttaat ggaaagatca aattggccgt gtttcgtgaa taaatccaac atatgtgtca 2983201 taaacggcac atctgtttta atatccgctt gtcctccgcc gtctattgta aatgccagct 2983261 caatatctgt ttcgtttgtt ttcctgacgc gttccgcttt tctcatttag aaatcctccg 2983321 ttctctcgct tcaattgatc tggcatgggc ttctaaccct tccagtctgg caaaagccgc 2983381 gatgctttcg gcatgttctt caaaggctga ttgactgtaa gaaataatgc tcgatttctt 2983441 ttgaaaatca gttacgttta atggacttga aaatctggct gttccgtttg tcggaagcac 2983501 atggttcggt ccggcaaaat aatcaccgac aggctcaggg ctgtatctgc ctaagaaaat 2983561 tgcacccgca tgtttgatac tgccaagcaa agcttccgga gactgtgtta tgatttctaa 2983621 atgctctggc gcgagtgtat tgacagtctc aatcgcttct accattgttt ccgccacata 2983681 tatacaaccg taatctctca ctgaagcttc cgctatttct cttcgcggca aggtttccag 2983741 ctgcttattc acctcggctg aaaccgtctc ggccagcgcc atggaatctg tgacaaacac 2983801 acatgagcta agcttatcgt gttccgcctg tgacagcaga tcggctgcaa tttcgctcgg 2983861 aatcgctgtt tcatcagcca gcacgacgat ttcactcggt ccggcaatca tatcgatatc 2983921 gacatcgccg aacacttctc gtttggcaag cgcgacataa atgttgcccg gacccgtgat 2983981 tttatccacc ggctcaatgg tttctgttcc gtatgctaac gccgcaatcg cctgagcgcc 2984041 gcccattttg taaatgtctt ttatgcccag ctcggctgca gcaaccaaaa ctccaggaga 2984101 cagcagaccg tcttttcccg gaggcgtgac gagaacgatt ctttcaacgc ccgctacgag 2984161 cgccggaatc acattcatca aaacagatga aggatatgcg gccgttcccc ccggcacata 2984221 tacaccggcg gaatccagcg ccgtcacttt ctgccccagc attgtgccgt cctttctgtg 2984281 ataaaaccag gaggattgca gctgtctttc gtgatattcc ctaatatttt cgattgcctg 2984341 cctaatcacc tgaagaagac gtgaatccag tgaggtgtat gcctcctcaa attcttcttt 2984401 tgtgaccagc gggctgtcta tttcgatgca gtcaaatttc gccgtgtagc tgcgaaccgc 2984461 ctgatcaccg tttgctttaa catcttcaat aatggaccgg accgtctttc tttgctcttc 2984521 cgttccggca tcgatggaac gcttgagaga aagccgttcc gctccgctga tggttttgat 2984581 cttcattttg ccgtctctcc ttccacaacg agagataggc gggatgccat ttcgtcaatc 2984641 acatcgtctt tcatgcgata gcttaccggg ttgacaataa agcgagaggt aatgtcacaa 2984701 atgtgctccg tttcaacaag cccattttct ttcagcgtct gtcctgtgga aacaatgtcc 2984761 actatccgat ctgcaagccc aatgagcgga gccagttcaa ttgaaccgtt gagcttaata 2984821 atctcgactt gttctccctg ctctctgaaa taactggaag ccacattcgg atactttgtc 2984881 gcgattcttg gcgctactcc gctccagtct gtattcggaa gtccggcgac agctaagtgg 2984941 catttgctga tgtttaaatc cagtacctca tacacatcgc gttcctcctc cagcatgaca 2985001 tccttgcccg caattccgac gtctgccacg ccatgctcca catacgtggt tacgtccatc 2985061 ggcttcgcta atataaaccg aagattttcc tccggcacat cgatgatcag ttttctcgaa 2985121 tcttcaaact cctcagggag cctgtagcct gcctgcctca gcagccctgc cgcttcttca 2985181 aatatccggc cctttggcat cgccattgtg agtaacttac ccattttgct cttcctttct 2985241 ggcaccgata aaataagtga cgtttgcaaa agattttgtc atctggtcga tattttctat 2985301 tcccgataaa tcttgaagaa ccactttgtt ccctttcatg cgttcttcat tcgcataagc 2985361 gatggcttgc gcccgctgct ctttgctgaa aataacagcg tctatttcac aaggttcgtc 2985421 cttcatatga agggcttcaa tcagccggtc gatccgaagc ccgaagcctg ttgccggtgc 2985481 aggtgaatca aaatggccca gcagcttgtt gtaacggccg ccgcttccaa tgacaaaacc 2985541 gacattctcg gcgtacactt caaataaaat ccctgtgtaa tagctcatgt ggctgaccat 2985601 attcagatcc aggcggacat tttccgtaca tccgtaatcc tcaagaatgt cccacagcgc 2985661 cttcagctca tcaaccacgc tttttccttg cgcagaatcg acgatttcct cggcacgtcc 2985721 gcatacttct ataccgcccc gcagttcaag gagctcaagc agcctgcttt tatcaatgga 2985781 ggaaagcggg agagacttga catgctctct gtagccgacg tagttctttt catataagaa 2985841 cctccgcagc acatcagctc gttcaacgtt tccgagcacc tcaacaaaca aagcatccgc 2985901 aatgccggca tggccaattg caattttaaa ggatgccagc ccagcgtttt ttaatgcccc 2985961 gacgactaaa gcaatgacct ccgcatccgc gctcgtcgtg ccgtcaccga ttaactccac 2986021 tccgacctgc tcgaactcag ccggacgtcc gccttcacgc tcctgagccc tgaatacatt 2986081 tgccgcatag ccgactctta gcggatgacc gtgtttcaga agcttcgatg ccgccaccct 2986141 tgcaatcggc cccgtcatat ccgggcgaag caccaatgtc ttgccgtcct gatcaagtag 2986201 cttaaacagc tgctgctctt caattgctga ctggacgcca acggtatcgt aaaactccag 2986261 tgtcggcgtt tccataaatt gatatcccca tttatcaatc aaatcggtta acgatcgtct 2986321 cacctttttt ttcgtttcgt ataaaccggg cagtgtatct ctcatgccgt gcggtttttc 2986381 aaacataaac atcaacccga gcacctccgc tgttatctta tgaaggaaaa ttccgaatcc 2986441 tttagttcgc taatatgata atatgttagc agatgaaaga atgaaaatca acgcttaact 2986501 tcagtaagga tatttttagt tcaaatatcc ttctcctcat tatgaaaaaa tcatgaataa 2986561 tgtattaaag gtacgtaata tctcaaattc tttatgtttg gcatgctata atacaaatca 2986621 aatagagaac aaggagataa agatgaaaac actgcgaact ctatgtgtcc tgatgattct 2986681 ttcaggcgtt atttttttcg gacttaaaat agatgcaaaa gatatagata ttcctttttt 2986741 gaacagcctt aaaaaagtgg tttctgatag cgatacagac tcagctgcga atagcaaaaa 2986801 ggagctgaag ggaagcgcaa aaccgctgga tgtcatcctt tacaatcaaa tggacgcacc 2986861 ccggctctat aacggctgtg aagtaacaag ccttgcgatg gtgctgaatt atgcgggata 2986921 cgacgtgaca aaaaataccc tggcaaatca ggttgccaca gtgcctttga catacagcag 2986981 cggattaaag ggtgatccga atgacggatt tgtcggggat atggcgaatg gccctggtct 2987041 cggtgtctac catcgaccga tctatcagct ggcgaaaacc tatgcgggag acaaagtgtc 2987101 tgatctgact ggaaaaagta tttccgctgt ttatcagcag cttgaaaaag gcaatccagt 2987161 ttgggttatt acgacagcca actttacgcc agttgacaac atgcagacat ggaaaacgcc 2987221 aaacggaacg atagaaatta cgtacagcga acacagcgtc gccgttacgg gatatgatga 2987281 taaatatgtg tatctcaatg atccgtatgg ctataaaaac agaaaaaccg atagaacaag 2987341 ctttgaaaaa gcgtggaaac aaatgggcag ccaggccgtg gttattcaaa agtaaacacc 2987401 tgaagcctca ctatgctcta ttctgagcaa atacgacaat attcatgctt tttgtatcaa 2987461 tcggtaagat cgattcattt tccatttttc acccaaaatt gtctttactt tcaggctgtc 2987521 tgtttttatg attaaagcag attcagcctt gccccgatct atgcgagaga agccggtgca 2987581 agtcgctgac gcttctcttg caaaaaatga aagatatccg gggaggattt atcattgaaa 2987641 aaaatcgtgt ctatcctatt tatgttcggt ttggttatgg gtttcagcca gtttcagcca 2987701 tcaaccgttt ttgcagctga caaagtggtg cacgaaacaa ttatcgtacc aaaaaataca 2987761 acatatgacg ggaaaggaca gcggtttgtg gcagggaaag aattaggtga cggaagccag 2987821 tcagaaaacc aagaccctgt ttttcgtgtg gaggatggag caaccctgaa aaatgtggtg 2987881 cttggtgcac ctgcagctga tggcgtgcac acttatggaa acgttaacat tcagaatgtg 2987941 aaatgggaag atgttggtga ggatgcgtta acggtgaaga aggaaggaaa agtgacgatc 2988001 gacggcggtt ctgctcaaaa agcgtcagat aagatattcc aaatcaataa agccagtacc 2988061 ttcacagtga aaaatttcac ggcggataat ggcgggaagt tcattagaca gcttggtggt 2988121 tcaaccttcc acgttgatgt gatcatcgac aagtgcacca tcacaaacat gaaggaagcg 2988181 atattccgga cggacagcaa aacaagcacg gtcagaatga caaatacacg ctactctaat 2988241 gtcggtcaaa aatggattgg tgttcagcat atttacgaaa acaacaacac tcaattttaa 2988301 caaaaaaagt ccgctgatgt tattcagcgg actttttcaa tctttcttgc atttcttcct 2988361 tcgtatagat gatcctcatc ggatttccgc cgacaaatgc cccgtcaggc acatccttat 2988421 ggacaagcgt tccggcggac acaactgcgc catctcctat tttcaccccg ggcagaatgg 2988481 tcgtgttggc accaatcatc acttcgtccc cgatcagaac tttgccgatc cggtattcgt 2988541 gaatcaaata ctcatgggcc agaatggtcg tattgtaccc gatgattgta tttgttccga 2988601 ctgagatctt ttccggaaac atgatatctg gcatcaccat gagggcaaag gatgtctgtt 2988661 ttccaacctt catccgcaga aatgtgcggt acagccagtt tttcatccct ataaacggcg 2988721 tatatctcgc aatttgaatg acaatgaaat ttttgacgac ctttaaaaaa ggtaccgttt 2988781 gatagacatg ccacagtgag ttggcccccg agaccggatg acgatctgtt tttctcacag 2988841 attacttcac tccaacgatt tgtaatagat cactcatttt ctcaagcata aaatccggct 2988901 catgcttcgc cagcatttcc ggccctttaa tcgtccatgc gactcctgcc gtttttgtac 2988961 cggcgttttt ccctgccagc acatcatggt aattatcacc gaccataatg gcttccgccg 2989021 gctcgcttcc tagctgtttc agcgctaaca gcacaggctc gggatcaggc tttgcattcg 2989081 tcacatcatc aagggtgaca actgtttcaa agaattcgcc gattcccgtg agcttgaggc 2989141 ccatattgac agtatctctt aattttgttg tcacaattcc taatgtaaag ccggcttttt 2989201 ttaatgcatc cagggtctca tataccgttt catattcagt gacgagtgaa tcatgcatgt 2989261 catgattgta cgctctgtac atagcgatca tatcctcgca tttatcaggg tccatcgaag 2989321 agaacgtatc aaaaagagac ggcccgataa atgcaaggac atcttctcgt ttatacttgc 2989381 tcggataata atgctccagt gtatgcaaaa aggacgcgat aattaattca ttcgtattaa 2989441 taagcgttcc gtctaaatca aacagaatcg tcgttacttg tttgtcactc atattgcttc 2989501 ctttccaacc gctgagggtt tccatttttt ccacgtgtgc gcaatagcca ttgtcagcag 2989561 aactgctgtg gtgacacgaa tcaaaagaag cggccagacc ggtatgccaa gcggaataaa 2989621 gacaagtgta tcttccacga ccgcgtggca ggcaacgaga aatataaatg ccaatgtcat 2989681 gtcccgcttg ctcacgccgt catcctcgac agctttgatc atgacacccg ctccgtaggc 2989741 cagaccaatc gtcagtcccg tcaccatcgt catagacgta tttttattca tgccaagcag 2989801 ctgcgtaaac ggcgacagcc acctggaaaa ccgataaagc cagcctaaat ctcttaaaaa 2989861 ctggatgata atcatcagcg ggatcactat tgccgccagc tgcaaaacac caagtccggc 2989921 tttcgttaat gcttctgcca acattcctag ccagctgtct ggcgccgcgc tcttcgcagc 2989981 gataaaaccg tactgcgccg tttcctttcc gccatgccaa atgaggttga tgacgatggc 2990041 tgacacagcg gccaaaccga tgcgcacggc caatatgacg ccaattctga taccaacctt 2990101 tgcggcaact gtcgattcga taatcaagtt atgacagaaa gaaagcataa cagctaaaat 2990161 aaagacttct ttcacagata aatccaatgt taaaatcccg gcaattcccg catacagatt 2990221 cagcatattt cccagtacaa gcggaatggc cgcttcacca gaaagcccga agagacccat 2990281 taccggtgtg atcagccgta caagccaatc catgacaggg gtatgctgga gcaaagtgac 2990341 caatagcgtt accgggaaaa tcactttacc cagcgtccat gttgtttgaa aacctgctgc 2990401 aagaccggcc agaaagatct tcttcatccc tcatccccct ttgttgacgt ctactccgcg 2990461 taccgctcct tcgagtatcc cttgacgcgt ctgaagatga tggctgccac agccaaaaca 2990521 atcaatacga ttgaaatcac ctgagcgatg cgaagtgaat cagtcagcat taagctgtca 2990581 gtccgcattc cttcaataaa gtatcttccg attgaatacc aaatgatata gatcaagaac 2990641 atctcgcctc tacgcaaatt cgctctgcgc agcagcagta aaacaatgac gccgacaaag 2990701 ctccatagtg attcatataa aaaagtagga tgataatatt gcccattgat atacatttga 2990761 ttgatgataa attcaggcag gtgcaggttt tctaaaaagg ctctgctgac agcctcgccg 2990821 tgcgcttcct gattcatgaa gttcccccag cggccgatcg cctggccgag caaaatgctg 2990881 ggcgcggcaa tatccgcaag cttccagaac gaaaggtttt tcactctcga aaacacataa 2990941 cccgttaaaa tggcgccgat taatccgcca tgaatggcaa tgccgccctt ccaaatctta 2991001 atgatttctc ccggatgtgc cgcataatag tcccattcaa aggcaacata ataaattcgt 2991061 gcgcaaataa tcgcaattgg aatggcaaac aggacaagat caataaacgt atctttctgc 2991121 agcccccgtt tttcactttc cctcatcgct atccacagcc cgagcaaagc gccgagaccg 2991181 ataatgattc cgtaccagtg gacggctaac ggccccagct gaaatgctat cggattgagt 2991241 ggttctatcg cttcattcat ttaacgccaa ctcctattct tcttgttcac cgtcttcaat 2991301 gacgtccgcc agcttgttgg taaattgttc agcggcattc agccccatcc gcttcaatct 2991361 gaagttcatt gctgccactt cgatgatgac tgcaagattt cggcctgggc ggacgggaat 2991421 cgtcagtttt gtaatttctg tatcaatgat tttcatggtc tcttcctcaa gtccgagccg 2991481 gtcgtattgc ttgccctgct cccagagttc aagattcatg acaatcgtga ttcgtttatt 2991541 gcttctgacc gcgccagcgc caaatagcgt catcacattg ataatgccaa ggcccctgat 2991601 ctcaagaagg tgctcaatta attccggagc gtttcccaca agagtatcct gatcctcctg 2991661 ccgtatttca acgcaatcat cggcaacaag gcgatgccct cttttcacaa gctctagcgc 2991721 tgtttcgctt tttccgacgc cgctttttcc tgtgatcagc acgccgacac catatatatc 2991781 gacaagaacg ccatgaattg ctgtggtagg cgccagcctg ctctcaagga agttggttaa 2991841 acggcttgac agtcttgtcg ttttcagcgg cgatctgagg acaggcaccc catttttctc 2991901 ggaggcgtca atcagctcct gcgggatggg catatctcta gaaagaataa tagctggtgt 2991961 tacatcagtg cacagagaat ccattcgctg ctttttctcc tcttcaggaa gctgttcaaa 2992021 gaaagaaagc tctgtttttc cgagaagctg cacgcgctcc ctcgggtaat atgtaaaata 2992081 tccggcaatt tcaatacctg gtcttgatag gtcactcatt gtaatcgggc ggttaattcc 2992141 ttcttctccg ctgattaatt ccaaattgaa ctgttccatt acgtcttttg tgcgaacctt 2992201 tgccacgata tgttcctcct gttccgggct gccccgagct tgctcacaat actttcattt 2992261 tatcactttc gggcttgaac ctaaaacaga ttttataaaa ggggggaaaa cacctcagct 2992321 ggtctagatc actagtctga aaaagagtaa aataaaggta ttcaaattcc agaaaggcgg 2992381 atcatctatg gcagagagtc ttcttatcaa agacattgcg atcgtgacag aaaatgaagt 2992441 aatcaaaaac ggctatgtcg gaatcaatga cggaaaaatc agcacagttt caacagaacg 2992501 gcccaaggag ccatattcaa aagagattca agcacctgcg gattccgttt tgcttcccgg 2992561 catgattgac attcatatcc acggcggcta tggcgcagat acaatggatg ctagcttttc 2992621 cacgctcgac atcatgtcgt caagactgcc cgaagaaggc acgacgagct ttttagccac 2992681 aacgattacc caagagcatg ggaacatttc tcaagctttg gtgaacgcaa gagagtggaa 2992741 agcggctgaa gagtcctctt tattaggtgc agaactgctc ggcattcatt tagagggccc 2992801 ctttgtttcg cctaaaagag ccggagcgca gccaaaggag tggattaggc cttcggatgt 2992861 tgagcttttc aaaaagtggc agcaggaggc gggcggactg atcaaaattg ttacacttgc 2992921 gccggaggag gatcagcatt ttgaactgat ccgccatttg aaagacgaat cgattatcgc 2992981 atccatgggg cacacggatg ccgattccgc attgctgtcg gatgccgcaa aagcaggggc 2993041 gagccatatg actcatctgt acaacgcgat gagcccgttt catcaccgag agcccggagt 2993101 gatcggaacg gcgctggccc atgatgggtt tgtgacagag cttatcgccg atggcattca 2993161 ctcccatcct ttagctgcaa agcttgcttt tttggcgaaa ggcagcagca agctcatttt 2993221 aattaccgat tccatgaggg caaaaggact gaaagacggc gtatatgagt tcggcggcca 2993281 aagtgtgacg gtaagaggac gaacagcact tctttcagac ggaacccttg ccggttcgat 2993341 cctcaaaatg aacgaaggcg cacggcatat gcgtgagttt acaaattgct cttggacgga 2993401 tatagctaat ataacttctg aaaacgcggc caaacagctg ggcatctttg accgaaaagg 2993461 cagtgtgact gtgggaaaag atgcagattt ggtgattgtc agcagtgatt gcgaggtgat 2993521 tctcaccatt tgccgcggaa acattgcatt tatatccaag gaggctgacc agatatgaaa 2993581 gtaatggaat gtcaaacgta tgaagagcta agccaaatag cagccagaat aacggcagat 2993641 acaatcaaag aaaaacctga tgctgttctc ggtttagcga cgggcggcac accggaaggc 2993701 acgtatcgcc agctgatccg cctgcaccaa actgagaatc tctcatttca aaacatcact 2993761 acagttaatt tggatgagta cgccggactt tcaagcgatg acccgaacag ctatcacttc 2993821 tatatgaacg accgtttttt tcagcatatc gacagcaagc ctagccggca ttttattccg 2993881 aatggaaatg cagacgattt ggaggccgaa tgcagacggt atgaacagct agtcgattcc 2993941 ctcggcgaca ctgacattca gcttctcggc atcggccgaa acggacacat cggctttaac 2994001 gaaccgggaa cgtctttcaa gtcgcgaact catgttgtga cattaaatga gcaaacccgc 2994061 caagcgaatg ccagatattt tccctccata gacagcgtgc cgaaaaaagc actgacaatg 2994121 ggaattcaaa cgatactctc aagcaagcgc attctgctgc ttatttctgg aaaaagcaaa 2994181 gcggaagctg ttcgtaagct gttagaagga aacataagcg aagattttcc cgcatctgct 2994241 ttgcacctgc attccgatgt tacggttttg attgatcgtg aagccgcgtc attaagacct 2994301 tgaaaggaac atgctgactt atgaatatca ataaacaatc gcctattccg atttactatc 2994361 agattatgga gcaattaaaa acccaaatta agaacggaga gctgcagccg gatatgcctc 2994421 ttccttctga gcgcgaatat gccgaacaat tcgggatcag ccggatgaca gttcgccagg 2994481 cgctttctaa tttagttaat gaaggcttgc tctatcgcct gaaagggcgg ggcacctttg 2994541 tcagcaagcc aaaaatggaa caagcacttc aagggctgac aagctttacc gaggatatga 2994601 aaagccgcgg gatgacaccg ggcagcaggc tcattgatta tcagcttatt gattcaactg 2994661 aggagctcgc ggctatatta ggctgcgggc acccctcctc tatccataaa atcactcggg 2994721 tgcggctggc aaatgatatt ccgatggcga ttgagtcctc acatattccg tttgagcttg 2994781 cgggtgaatt gaacgaatcg cattttcagt cgtcgatcta tgatcatatt gaaaggtaca 2994841 acagcatacc gatttcccgt gcaaaacagg agcttgagcc aagcgctgcc accacggaag 2994901 aagcgaatat tcttggtatt caaaagggag cgcctgtcct attaattaaa cgaacaacat 2994961 atctgcagaa cggaactgct tttgagcatg caaaatccgt atacagaggc gaccgttata 2995021 catttgtcca ctatatggat cgtctttcat aaaaaaagcc tccaaccctt tttaaggatt 2995081 ggagacatgg cgaaaatcaa actggtctgg tgccggacga tatgtttctt ttttcgtctt 2995141 gaacttccag atcggtgatt tcgttttgcc gttaaaactg tcttccacta taatgtacca 2995201 ataataaaca gactgcggtt caagatgatc ccagcggaat tcagctgtgt ccccgctctt 2995261 cacttgctcc cgttttccga gctcttcatt ggtatatacg ttacattcaa aataatcggt 2995321 ttccaccttt ttgattcttg gcttcaaatc aagcgaaagg gaaaattcat ccttgttgcc 2995381 ataggtatcc gtatcatagt agttcttatc ctttacatac ggagagtacg tcgatacgtg 2995441 caccatgtca ttggcttggt caaattgaag caaacgcaaa tacccttggc cgccttctgg 2995501 cccgccctga taatcggcca gcatttgatg cacaagacga tccggtttcc catcaccatc 2995561 atcatccagc tcatctgttt ttctcatcgc actatgataa tgcccgctca acaccatcac 2995621 gacattcggg ttcggcttta cgatttcttt gaatattttc tctccgattg ggcttctgtt 2995681 tccgctgacc agcaaatact catgaaaagc taaaatggcc atccggtcag gatgcttctt 2995741 cagcacctga ttcatccacg cgatgtcttc atccgtaatg ccccatccca tgtacagcat 2995801 gatataatca ttgccgttgc tagaaatcag gtcataatgt ccgcggttat ttttatagga 2995861 accgccataa tgaaattttt tatcaaaacg atcgctgcca aaatatttgc caaacgccct 2995921 gtaggagccg tccttatgtc cgacatcgtg attgccggcc agcacgccgt aaggaattcc 2995981 gctcttatcc agaacggaca ttgaccgatc agcgtttttc cactgtctga tatcggcgga 2996041 atcatctaca atatcacccg tgtggaacac atatttgata ttgagctgct tttgattatc 2996101 ttttatccat tcggtctgtt tatcaaaaat atgcggatag ctttcggcgt aatactgtgt 2996161 atcagacatc cagacaaatg tgtacatatc cttcgcagga ggaatttcat cctgtacaat 2996221 cacattcatt ttcgactccc gtacaaaatc ggcggcaatc acagacgctt tcagcgtaaa 2996281 cggtttgtca tccttcgcga cgaagctgtc aacaggctgc cattcgtttg tccgataatt 2996341 ccaagcatac atcgtcacct ttctccccgg caaagaactg cccttccaga ctgattctgc 2996401 cagatcattc tcatcaattg atggatcaac cgtcacttca aagcgatgat aagggaaaag 2996461 ctctttgttt tctgtcgata ctgtttttcc atcagcagct gatacccgct ccaattcttt 2996521 attcgtaaat ggggtctccc tttccggcac aaagcttttc ggcggttcag tcagtgacgc 2996581 gtgcttaaat attttcacat gattgcgcgc tgtatattga aatcccctat aaaaaccaac 2996641 atccatggca tcattcgtcg gatctttcac ccgtacagaa agcttggcct tatgcgtgtc 2996701 ggcttcgctg tctataacct ccggctggtc cggatgctct cgttcggttt taaatatcct 2996761 ctcaatcact gttttattgc ccgcgagatc cgttgctgtc acttttagag aatgttttcc 2996821 cggcaaaagg tcagaagatg acgtatgata tgggagtgta atgctttctc catctaacga 2996881 cgcctccgct tcctcaattc tgctccattt atcatacata tccgcctgca ggataaggtt 2996941 tcctttatac gtttgcccct cggtgatatt cggctcaatg tgaggtcctg aattatctac 2997001 ccgtacaacc aggctgacat tttccttccc gtcgcttgct tgaatatggt gagcgccttc 2997061 agaaagcttt gatgtatccc actccagcag ctgtgatgta aatagtccgt caggcagatt 2997121 gaactgaaat tgccagcttt tattcgagcg ctgattatcg ccaataaaga gttccttctc 2997181 aggagacacc ctctgatctc tgatcaccgt tccatccgat aacaccaatc gggcgttttt 2997241 gactaagaag tcatcacggt tttcagccgt atcaaacgga gacaccttcg aacctgaacg 2997301 tatcgtaata cgctgcagct gcttcccttt ccgaagcagt gtctctggca atggaacaga 2997361 ataggtgcgg tatttatttg ttgtatcatc gaacaccttc agcactttgc cttccatcgt 2997421 taccgcgttt ttaaaataaa ggttcgtttt cctcgtatcg aatgcaaaat atacttcttt 2997481 ttccatcgcg ggctctgtca cttgtttttt cccgtcaatc catagcttaa tgctgtcagc 2997541 tcgcccttct gtcgtggctt tgagaaattg agttcccgac agcgtgtctc tgttttcaat 2997601 attcatccgc agaccgtgcg ccttgcttgt ttgtttaata tcaatcattt tgaccggcgt 2997661 tctcgcttca ttgatcccgt ccccggccgc cacataatac tctagctgat ccttcccgat 2997721 caattcaggc gaatacacaa tataatggaa gagattatcg ttgcggtctt tttcagcaag 2997781 aattcgctta aacggtttgt tctcatccgt ccggtagtaa aaggccactg ttttcactag 2997841 gcttcggtcc cgtatgtcag cccgcagctc aatgctttca gcagggcgga caggcttgcg 2997901 gtcagtcaaa tcctcaatga ccggcttttc tttatcgagc ttgattttcc gtttctggtc 2997961 gggcacctgt gcctgtaata cggttccggg agacggattc ttttccccga ttgaaatgtt 2998021 cagaagttct gctgttccgt tcagtggata cttataaagc actgatgaca gccggcgcag 2998081 cgcatgtttc cgataatgcg caaccgaaat gtcctttcct gtattcgttg atatcacaac 2998141 ggcccgcggc ctcgtattgg ccataccctc tgtctcgtct atcaccgcaa gattttttcc 2998201 ttcttttagt tgtgtctgat aataacgatt gaaatccgct gacgtcaatt ctggatgccc 2998261 ggcaggcttc agccagacga caaacgtttc gccggatggt atcaagatcc tttcatcagg 2998321 tctccaaatc agatcggagt caggcccttc ttttgggtag cggtaacgga tatggtagtc 2998381 tttaaaatca atcgttctgt cagtcgtatt aaaaatctca ataaattcat aaccgtctgc 2998441 gcgtcctata ttcttcgtat caaccgccag ctctgtgatc agaagctccg gaatatgggc 2998501 aaggtcagcc tggtatcctt caagcttcag tttcttcgtc tccgactcaa cccgctgctt 2998561 cccattcgac atcacaatgt aatactcaag ctcgctgttc caaatcaaac gtttcggaat 2998621 ttgtgccaaa aacttgcgga ccgctccggg ggtcgggtcc atcggcacca ttttgtagcc 2998681 cagctcatta ctttgtttat aaaaaagaaa ggcggaaaat gcttgatacg aattatcgcg 2998741 aacttgagcc tcaatcatta gattgcttct catttcagct ttcacatcaa tttgaggagg 2998801 attttcaagc aagggtatgt aatgaggcgt ttgaaatagt tcctgctgta caacaggaaa 2998861 agctttcgat tcatgatggc cgccagacaa aacggaaaga aaagacagta atatagaagc 2998921 aataaccgtg tatttcctca tcaaagcacc tcccttttca tgtattttgc gtctgaacag 2998981 ggaagcttat gagttcattt ttgtgcataa agaacaaaaa aacgtctgtc tcttgaaaat 2999041 tccactatta cccagtaaac taaggatagt taaccagtta acaattaaat cagagaggca 2999101 aattgatgga caacagcatt catgatgaat tatttcaagc tatacaacaa ttcgcattaa 2999161 aaagggataa acgcgtctgg caaaaggtgc agataccatc cattggcata tcctcacaac 2999221 atcacgatca cctcaaaaaa gactggactt tgacccagct tcacattgtt tcctgcatac 2999281 ataccagcca aaatgtgaac aacagcttct tagcatcccg tttacacatc tcaaaagccg 2999341 ctgtttcaaa agcggttcat gctttgttga aacacaatat cattacagtg acaaaaaagc 2999401 ctggcaacaa aaaagaaatt ttttatacgc taactgatag cggcagaaaa ttggcggcat 2999461 tacatgaaca gcttcatgag aaagcaaagg agcaatataa acagcttttc aatgaatttt 2999521 caattgatga tttaaaaaca gtgactgcgt ttttcaactt gtggatcaaa tatatgtaaa 2999581 aagagtctca cccgcatggg agagaccttt ggaattctat tatgccccgt caaacgcaac 2999641 gagaagtgaa acaggtccgc gtgtatacag accggactca gcataacaaa aatcttcctc 2999701 taatctgata ttccgcatct tatccagcac aatattagct acaatttcga tttcgttttt 2999761 ggcaaaagct gctcctacac agttatgaat gccggatccg aaagcgagat gccgggcggc 2999821 gccgctaaaa gcgctcttga taccaagatc ttcccgatga atattaaaca cgtcaggctg 2999881 ttcaaatgct tcagggtccc ggttagccgc accgatcata caaaaaacaa tcgtatcttt 2999941 tttgatttcc ataccgccga ccactgtatc ttgggacagc tgccgcggaa tcagctgaac 3000001 cggcggttta taacgcaatg tctccgcaat ggctctcgga actaacgaac ggtcagccaa 3000061 aacatcattc atctgctcag gattgttgag caaatggtag atcatcagtg ccagcgtctt 3000121 atcagccggt tccgttgcgg ctaacagcac attaagaatc agtgcgagta tatccttgtc 3000181 cgacagcgcc atgccttcat attcagaagt acataggatc gaaattaaat ctgatcccgg 3000241 attgacgcga cgttctttaa tgaccggcat caagtattgg gaaagctgtt cgctgcacca 3000301 taacgaatgt gcccgcgctt caggagattg agagatactc gtgataaaat cggcaactcc 3000361 gctgtgccac tcagagattt tttcatggtc tcttttatcc agcccgagca tgtccatcgt 3000421 gacgcacacc gcaaacgtct ttccaaaatc attgacgaga tcacttttcc ctctttcaag 3000481 ataaggcgct aacaagtttt ctgcattttg tttaatcaat ggagacagat gatccagtgc 3000541 gtcaccgata aagcttctca ctacaattct tcttttggca gagtgttctt ttccatgcat 3000601 ttgggccagc acagggcctc gcatgactgg ttcggcacgc tcaacaagtg atttcgtcgt 3000661 gaagatatcc ggatgctgaa ggatatagcg gacatcatga tagcggctga taaaataact 3000721 gtctatcgac tcttcataat gaaccggatc ttcctcccgc agttgtgaaa aataagcata 3000781 tggattgttt tgaaattgat cagaaagcac actaaacaat ttaatcgatt ggctcatgtt 3000841 ttactccccc tatcatcctt cagatgtgat ccgtttctca gaaagcatct gcgccatttc 3000901 ctgtacaatg agataccctt gattcggccg catacaaata gaaaattcat ggttactgat 3000961 cttctcaccc agcttccacg gacgatgata agcaaggagt gtctcttcca cctctaaaat 3001021 atccggagct ccgataaaaa acggcagctc agctatgaca tattccacag ccaaattcag 3001081 catatcctca ctgacttctt ccatcatcaa actgacgccc cgcgcacgcc cgattatcgc 3001141 ttcacgagac atgtccaaac aagcatgtcg aaaatgaggc tgctcaaaaa atgcatgttc 3001201 aacttcttgt ctcaacagct ggtaggcttt gttatctata aaatcagaaa atgtatgaat 3001261 cgccttcgga tccccgccat gagccacaag ggctctttct gcaaatctcc tgtttcgtga 3001321 tacctctttc cttacttttc gttcagcctt tcctctcgga gttccaagcg cttctagaag 3001381 attagccgcc tcatgccctg caagtaaaac tgaaacgctt ttaaattgag ctttcgccca 3001441 tccaattaat ctgtaaatat aatcctctga aaacctgctg ttaaatgggc tgatccccac 3001501 caaaacatgc ctgcgccgtt caaatatttc tctgcagttt tctgttaatg cctcagcaat 3001561 aaaatgcaca gaccttcttt ccgttaccat tccggtcatc tcattcaccc ctaaaactta 3001621 tcccgcttta agtcatcacc ctcaaataca agatggaata gctagaacaa ctgaacaaga 3001681 cgaatggcag gcatcactta aagtttccaa atgtttttta agattttaat aatcattttc 3001741 aatacccata tcatgataaa tgtttactag taaacattag tcattttatc ccttttcctt 3001801 ccaaacgtca atatgatctg tgcccaaata tttgaaaata aatgtaaaca tcacattttc 3001861 cacacacttt ttacacgcat attcagcatg acatatcaac aaatagtcta aacaccaaca 3001921 attgacaacg aaaacaagaa aagataaaat aaaattgttc accagtaaac gatttgtttt 3001981 attgtttcat cgtaaactat tattcctaag aaagaaggta gcctatgtct gatttgacaa 3002041 aacagatgat atacgacata tacgtgagac tgctgcacct taatgaacaa aaagcgaaca 3002101 cttcacttca gcaatttttt aaggaggccg cagaagagga tgtagctgaa attcccaaaa 3002161 atatgacaag cattcacgtc attgactgca tcggccagca tgaacccatt aataatgccg 3002221 gaattgccag aaaaatgaac ttatcgaaag cgaatgtaac gaaaatcagc acaaaactga 3002281 tcaaggaaga attcattaac agctatcagc tgacagataa caaaaaagaa gtttatttta 3002341 aattaacccg taaaggcaga cggattttcg acttacatga gaaactgcat aaaaaaaagg 3002401 agctggcttt ttaccaattc ctcgattcat tttcacaaga agaacaaaag gctgtattga 3002461 agtttctaga gcagttgacg tcaacacttg aagcagaaca aaccgatggg actccagaca 3002521 aacctgtaaa gtaaacaaaa aggcggtgta cactttggct catacaaaat caaaggcagt 3002581 attgatctta tacactgttt gcttcagtgc attttttgca tctttaagcc agaacattta 3002641 ttcacctatt cttccgatca ttaaagaatc attccatgtt tccacagcta tggtgaacct 3002701 gtcagtctca gtttttatga ttgtgacagc aataatgcaa attatattag gagcgatcat 3002761 tgattttaaa ggcgctcgga tcgtcttgat taccggtatt ctggcaacgg cagcagccag 3002821 catcggctgt gcggtgacta ctgactttac cttgtttctg atattcagaa tgatacaggc 3002881 agccggttcc gcagcactgc ctcttattgc tgccacaacg atcggacagc tgtttacagg 3002941 aaatgaacgc gggagtgcaa tgggaacgta tcaaatgctc ctgtctgtcg caccggctat 3003001 tgctccagtt ctaggaggat tcataggcgg agcagccgga tacgaaggga ttttttggat 3003061 acttgcggcc atctctatcg ttttgctggt gacaaacagc atcacctttc ctaaagattc 3003121 tccaactgaa tctatgcagc aagccaaagg caatgtgttc gctcattata aatcaatatt 3003181 tacaaatcga acagggaacg tcattttgac tttaagtttt gttctctttt tcatttattt 3003241 tgcagtaatt gtctacctcc caatattgct gacagagcat taccatatag atgtgggtat 3003301 agcaggactg ttatatttgc cgctggcgct gagcacgatt gcaggtacgt ttctgtttaa 3003361 aagaatacag gcaaaaatcg ggctgcacac cttgtttatc ggaagcaatg tgattgccgc 3003421 ctgcagcatc attttatttg ctgttacaca ttccgtttct ctcgttctca tggctctgac 3003481 gctggcactg tttggcatct cgatgggggt tattcctccc ttgtactcta caatgattac 3003541 taatgaattt gagcacaaca gagggagtgc aatcggaatg tttaacttta tccgatatac 3003601 aggcatggca gcaggtccga tggtatctgc ctacttgctc acaatgatgc cgtctgccat 3003661 gtcctttagc ctcctaggcc ttggatttgc cgcattgagc ttttgccttc ttccgccaat 3003721 gttttcgccg cagaagcgca cgaaacaaaa aaagcaccac atgtaaaaaa gctgcctttg 3003781 cgggcagctt tttttatttt tttctaagcg gctctaaaat gcctttttga atcagcaaat 3003841 ggaagaccga caggataacg gatgcccata tcgctgtgcc gaagccgtcg atttgaaagc 3003901 tgtcacccat aatggacgcg gtcatcataa gcgtgatggc gttaatcaca aacaagaaga 3003961 gtccaagcgt caccatggtg accggcagtg taaatataat taaaagcggt ttaatcagca 3004021 cgtttaagat cgataaaatg aggctggcga taatcgctgc cccaatgctg ctgatatgga 3004081 tggagtcaat atatccatca atgacgatta ataacaatgc attgactaaa atgctgactg 3004141 cccattttac catgtcattt catatccctt tctgacggga cgataaaaat ccaaatgata 3004201 taaatgagca aaaccggcaa gacacttgtc ataatggcta agatgacagt tatgactctg 3004261 aggagtgatg cgtcccaatt gaaatattcc gcgagacctc cgataacacc ggcgattttc 3004321 ttattttttt ctgagcgata aagcttattc attcgatcac ctctgtgagt actttagttt 3004381 gatggcgcct gttagtgatt ctgagaagac ggtgatgttt tgatcatgtg cctgatttga 3004441 agtgaacatc atttcttttt gaatcgtatc atttttttcc ttcagcatct ctacatccat 3004501 taattcatgg gacagcgtac caagattgct tttcagctct gccttcactg cgagatcgtc 3004561 cggaattgca agctctacat ttccagtcgt tgtttttgca taaatggagc ggcagtctga 3004621 ttctgttacg ttaatcgcaa tatttccgtt aaagctttga acgtcaatgg attcgctttt 3004681 ccctcggaga tcgatcaatc cgttaatggt ttccgcttct atcgtaccgc agctgtggct 3004741 tgcgagctta atttgcccgt tggccgtttc agctatggct ttttcggctg ttaaatacga 3004801 gaacgacagc acgccgtttg tcgttttcgc tgagaactct tttacatgta aatgttcccc 3004861 tctgactgga ccgttaaaca gcttcacccg aatcttatca tactccttct gaggaatata 3004921 caaagtgaca ttcgttttca tcgtcttttt ctcagtacgg ataaaaaact tattaccttt 3004981 gatttcacat tcaatatgct gaagaaatgc gtgtctcgcc gcatcctggc tgtcagcgcg 3005041 atataccttc gcctggcatt ccgctctgat atcgtcatct tcccaaggga cgatatttac 3005101 gctgccattg gcaatttgca gctcaacact ggaaaagtca gtatctttaa attgaaaaat 3005161 gtgctgaaca tcatacgcat ggccaaagtt taaatcaagg tcaacttcct tgaccttttt 3005221 cacagcagaa tcaatccagt caaacagctt ggctcctaaa gacggtttgc cgctttcttt 3005281 ttttgccgtt gtaaatggct cttcctcgtc atgaacgtga actgagagcg ctgtgatttt 3005341 ctcttctttt tccttgtagt cgctgtcaag cttttcaatc agtgtcaaag cttcttgtgc 3005401 tgtaagcttt ccttcctcaa caagcttaag gattcgttcc ttttcttgct tcattacgat 3005461 ctcctcccca ttgtctactt atgctgcacg caggacctta atgccctgaa tcacattcca 3005521 aatgataatg ccaatgacaa ctaagaaata aataaccgct cccccgatga ttacaaatac 3005581 aggaagcaag ctgtctccat caatcgcaac ggctccgcca agtaaagcaa taaaaaggaa 3005641 cagccagccg acaaacggaa caatgtgaga aataagagag cgtatcgcat ggcgttttgt 3005701 ttctttctca tttacaacaa aatatgcgac aatcggcaca atgattggcg caatgaacac 3005761 actgaaataa caaagtgatg caataatagc ttgattacgg ttcaattcat tccacactcc 3005821 tattgtgaat tgtccatgac aaaagatcag ggacgtttta cttatttata cgtttaaaat 3005881 ctcttcaggt ttcaaattca ttctttagac atgctccgat ttacggaaat tggattttaa 3005941 aaagttttag aagtagaatc ttccggctat accgattaca atatgtaaaa agcttacggc 3006001 aaccaaggag gctggacaag caatggagaa agatcccagt gactatacag taacacaaga 3006061 atcagtgtta aagctgattc aggaacaaaa aagaatgaat cgtgaaatga tcaccgagct 3006121 tgagcagatt cacggaccct tcccgatctc tcacgatatc caatatataa aagtgctgct 3006181 cgacagcagc aacacacata ttgttcaaga tttaatgagt gtaagtaagc agctgtataa 3006241 gaagactttg taattgcgga aaacatatca ttcattataa ctgaaacaaa gctaaaggtt 3006301 agatgacaat atcttgcctt ttttgttttg aaaaaacaag tgattccctg gctgtcacaa 3006361 aatgattgta acaaaaaaag cctgccggca catccagtta atggactctg tcggcaagct 3006421 gtaactatca gaaagagata gccgttcaaa attaacgtaa caattgaagc acgttttgcg 3006481 gctgttggtt tgcttgagca agcatcgctt gagaagcttg agaaggaatg ttgttctttg 3006541 tgaactcgct catttctttc gccatgtcaa cgtcacggat acgggactca gcagctgtca 3006601 ggttttcaga agaagcacca aggttgttga ttgtgtgctc tagacggttt tgtaccgcac 3006661 caagtttagc acgttggttt gagacattgt tgattgcagt atcaatactt tcaagttgtg 3006721 tatcaaaagg agtattagca aaatctgtta cattaagtgc gtttactcct aaagcagttg 3006781 atgacatgct gtcaatgtta actgtaagct gctggccagc atttgctcca atttggaaag 3006841 tgaaaccatc agtttcagta ccatctaata actttttgcc gttgaattca gtacgatttg 3006901 aaatgccatc aacttcctca ataagcgcat ccatttcatc tttaattgca ccaagatctt 3006961 ctgcttgttg tgtacctgtg tttcctgctt gaacagtaag ttcacttcta aacctattat 3007021 gccgtaaaga aaaagcttgc ctgctaagcc caaggatgga cttgccgaca agctgtcccc 3007081 tcttaacaga gggttttaag atgtagctgt ttcttttgct ttcaagagcg atttcatgcg 3007141 tgttttgtca cgttcgataa caggctttaa ataacggcct gtatacgatt cttcaacttc 3007201 agtgatttcc tcaggcgttc cagacgcgac aatggttccg cctccggctc cgccttccgg 3007261 gcccaaatcc acaatgtaat cggccgtctt aatgatatca agattgtgct caataaccag 3007321 tacagtgtct ccgttgtcta ccaaccgttg cagcacgaca agaagcctgg cgatatcgtc 3007381 gacatgcaaa cctgtcgtcg gctcatctaa aatgtagagc gtacgtccgg ttgagcgttt 3007441 gtgcagctct gacgcgagct tcacgcgctg cgcttctccg cctgacaagg tcgtcgccgg 3007501 ctggccgagc gtaatataac ctaaaccaac atcataaagg gtttggagct tgcgtttgat 3007561 tttcgggata ttttcaaaga aagaaagagc atcttcaacc gtcatatcaa gcacatcaga 3007621 gatgcttttt cctttgtacg tcacttcaag cgtttcacgg ttatagcgtt tgccgtgaca 3007681 cacctcgcat ggaacgtata cgtcaggaag gaagtgcatt tcaattttaa taatcccgtc 3007741 tccgcggcag gcttcacatc gtccgccctt cacgttgaag ctgaaacggc cttttttata 3007801 gccgcggacc ttcgcttcat ttgtctgcgc gaatacatca cgaatgtcat caaatacacc 3007861 ggtgtatgtc gcagggttgg atctcggcgt tcttccgatt ggcgcctggt caatgtcaat 3007921 gactttatct aaatgatcca aacctttaat ctctttatgg ctgccgggct tcgctttcgc 3007981 tttatgaagc ttttgcgcca gcgccttatg caaaatttca ttaacgagtg tactctttcc 3008041 tgaaccggaa acacctgtaa ctgctgtaaa cgtcccaagc gggaacttgg cattcacttt 3008101 tttcaggttg ttttctgatg cacctttaat ttcaatgtaa cgtccgtccg gctttcttct 3008161 ttcaggaggc aatgggataa actttttccc tgataaatag ctgcccgtta atgaatttgg 3008221 atcttccatc acttcttccg gcgtacccgc agatatcacc tgtccgccgt gaatgccggc 3008281 tcccggtcca atatctatta aataatctgc tgccatcatc gtgtcctcat catgttcgac 3008341 aacaatcagc gtgttcccga ggtctctcat atttttcaga gcgctgatca agcggtcgtt 3008401 atcacgctga tgcagaccga tagacggctc atctaaaata taaagcacac cggataaacg 3008461 cgagccaatt tgagtcgcca gcctgatgcg ctgcgcctct cctccggaca atgtacccgc 3008521 tgccctgctc aatgtcaggt aatcgaggcc gactttgtcc agaaagctta agcgctccac 3008581 aatttcgcgc aaaatcaaat tggcgatctg catatccttc tcagaaaggg taagatcttt 3008641 aaagaaggca agtgcgtcgg cgacagacag ctcggtaatt ttcccaatgt ggcggccgtc 3008701 aatcagtacg gcaagcgcct ctttctttaa ccgatagcct ttgcacgtcg gacaagactt 3008761 ctgagacata tactgctcca tttgctcacg tatgaaatcg gagcctgtct ccttatagcg 3008821 tctttcaatg ttgcgcaata cgccttcaaa ttgaatttca ccttcgcgga tttgtccaaa 3008881 atcattttca tatcggaaat aaatcaggtc atccccgctg ccgtacagca ctttatccag 3008941 ttgatgcttc ggcaaatctt tgaccggcac atccatatca atcccgtagt gggtgcagac 3009001 tgcctcaagc agctgaggat aatattgtga gctgatcggt gtccaagggg cgaccgcatt 3009061 ctccttcaat gacaaatctt gattggggat gacaagatcg gcatccactt caagcttcat 3009121 tccgagaccg tcacacgtcg gacacgcccc gaacggactg ttaaacgaaa acagacgcgg 3009181 ctcaagctca ccaattgaaa atccgcagtg cggacaggca tgatgctcgc tgaacatcag 3009241 ctcttcctca ccgatgacat cgatcataac ccgtccttca cctaaacgaa gcgccgtttc 3009301 caatgaatct gacagccggg ctgccacgcc ttctttcacg acaatccggt caatgactac 3009361 ctcaatggaa tgcttcttgt tcttttctaa ttcgatatcg tcggaaagct cagccatctc 3009421 gccgtcaatt ctgactctga catagccttg tttcctaatc tgttcaagca ctttgacatg 3009481 agcgcctttt cggcccgaga caatcggcgc cagcacctga agcttcgtcc gttccgggta 3009541 ttccagaatt ctgtccacca tttgctcgat ggtctgggat gtaatctcaa ttccgtgttc 3009601 cggacaatga ggcttcccta ctctcgcata taaaagacgc agataatcat aaatctcagt 3009661 taccgtaccg acagtagacc tcggattgcg gctcgttgtt ttctgatcaa tgctgatggc 3009721 gggagagagc ccctcaattg catccacatc cggcttatcc atttgcccta aaaactggcg 3009781 ggcataggca gacagcgact cgacataccg tctctgtcct tcagcatata tcgtgtcaaa 3009841 ggcaagggag gatttacctg atccggacaa acccgtgaca acgacaagct gatctctcgg 3009901 aatcgttaca tctatatttt tcaggttatg cgccctggct cccttcacct ctatccgatc 3009961 catagccatt tgttcatcat ccttccgctt ttagctctaa aagtaaatcg cgaagctccg 3010021 cggctctctc aaagtcaagc gccttggcgg cttccttcat ttcatgctcc atctgttcaa 3010081 cgactttctg gcgttctttc ttcgtcattt tcgacagctt cggcgcggct tttgttttgt 3010141 attccgcttt atcctcagct gctactgtgg cacgaatgac atcgcgaatt tctttattta 3010201 tcgttttcgg cgtaatgccg tgctcttcgt taaaccgctc ctgctgctcg cggcggcgtt 3010261 ttgtttcatt aatcgcaatt tccatagact tcgttatttt atcggcgtac ataatgacgc 3010321 ggccttccgc atttctcgct gcccgtccga tggtctggat cagcgaccgc tccgaacgaa 3010381 ggaaaccttc cttatccgca tccaaaatcg caacaaggga tacttcggga atgtccaaac 3010441 cttccctcag caggttgatg ccgacaagca catcgtactt gccaaggcgc aggtcgcgga 3010501 taatttcaat ccgttcaagc gtcttgatct cagaatgcag atagtttact ttaatgccga 3010561 tttcctttaa ataatcggtc agatcctctg acatcttctt cgtcaaagtt gtcacaagca 3010621 cccgttcatt ccgctcgatt cttgcttgaa tttcgccgat caagtcgtca atctgacctt 3010681 cgattggacg gacgtcaata agcgggtcaa gaagccccgt cggacgaatg atctgttcga 3010741 ccatttcatc tgtatgttca atctcgtacg gccctggtgt tgctgataca tacacgatat 3010801 tgtgcatatg cttttcaaat tcctcaaaac gaagcggacg gttatcaagc gctgatggaa 3010861 gccggaagcc gtgatccacg agcacctgtt tccgcgcctg gtctccgtta aacatgccgc 3010921 gcacctgagg aattgtcaca tgcgactcat ccaccacgat cataaaatcg tctgggaaat 3010981 aatcaagaag cgtatacggc gttgaacctg gaggccgcag agtcaaatgt cttgaatagt 3011041 tctcgatgcc ggagcagaaa cccatttcac gcatcatttc aagatcatat cttgtccgct 3011101 gctctaaacg ctgcgcttca aggagctttc cgttttcatg catgaccttc agctgctcct 3011161 caagctcctt ctcgatattt tgaatcgcct tctccatttt ctcggcccgc gttacgaagt 3011221 gggatgccgg gaaaatcgca acatgatctc ggtcgccgag aatttctcct gtcagcgcat 3011281 ctacttcccg aatccgttcg atttcgtcac cgaaaaattc aactctgaca caatgctcat 3011341 cacgggatgc cggaaagatt tccactacat ccccgcgcac acgaaatgta ccgcgctgaa 3011401 agtcgatatc gttgcgggca tattggatgt ctacaagttt tctgagcagc tcgttgcgct 3011461 caatttccat ttcagtccgc agtgacacga ccatttcccg gtattcctca ggcgaaccga 3011521 ggccgtatat acaagacaca ctcgcaataa taatgacatc tctgcgctca aacaaagctg 3011581 atgtggcgga gtgtctcagt ttatcaattt catcattaat actagcgtct ttctctataa 3011641 atgtatccgt ttgaggcaca tacgcctccg gctgataata atcatagtag ctgacaaaat 3011701 actcgacagc attgttcgga aaaaattcct tgaactcact gtaaagctgt ccagcaaggg 3011761 ttttgttatg ggcaatcacg agagtcggct tattgacttc tttaatcaaa ttggacaccg 3011821 taaatgtttt cccagttcct gttgcaccca gcagagtctg atgcttcttg ccctcctgaa 3011881 ttcctttcac aagcttttca atggctttcg gctgatctcc ctggggctga tatttcgaga 3011941 ctaactcaaa gcgatctttc acaaaaataa gcctccgttt ctttaacgaa atcttcctat 3012001 agatatagta acacaatgga aagcaaaatc actaaaaata cgaactaaag ttcggtggtt 3012061 ttttatttcc agctgttttt gtgtataaaa aacctgcttt taaaacgtaa aagcaggtat 3012121 tcagtcttta tattcattat gtccgattta ttcttctttt ttctctgcag cttttttggc 3012181 catatacagt ccgccagcca caagagacac aacatccaat cctacaataa aatacgtttc 3012241 tgtatagcct tttaaataag aggcaaacag caatgcagct gttaaagcga tcgccacata 3012301 atgattaaag gtgactctag taaatagaac aacaagcata aaagggaaaa acaatgcaaa 3012361 aacggctttt gtaatcaaca aaaaccctcc tcagggattc ttcatctgat ctgattatag 3012421 taaaaaatga agaatcggac aatcgtgcat tcgctccctc tacttacacc ataccccttt 3012481 tcagccaaaa tcaatcacca tatttgcatt ttggtgccgg tcaaaactta ttccatggtg 3012541 ccgctgttct aatcagcggc acttttttta ttacatcatc aagtccgccg ccagattccg 3012601 agaataaaag aaaataggca tacagtacca gtacggccgc atttttcagg ataatataac 3012661 caacttaact attcatttta tttaggactt tctgcgtttg acagcatttt cctgaaaacc 3012721 tacaattaaa tgatagtgtt tactatcatt ttttaaacac aggctccgca ataaaaagac 3012781 tagagagaaa aacaaaatga atgaagaaaa gaggggtttc aaatatgtat tctgttttat 3012841 ttcgccaggc agaagagtcc agccagctgg ctggagcaaa aggaatgaat ttgattaaat 3012901 tgaccaaaca cggtcttcct gttccggacg ggtttattat tcaaacgaat gcgctcgcac 3012961 gttttatgga ggacaaccag cttcaagaga ctagtgaaaa cgtcgaaggc gggatcattt 3013021 ccggaacatt ttcggatgag ctgaaagatg agctgactag ttccttttat aagcttagag 3013081 aatcatatcg atccgtagcc gtgcgttctt cgtctgcttc ggaagattta gaaggcgcct 3013141 cattcgcggg tcaatatgaa acctacttaa atatcaaaac agaggaagag tttctggcta 3013201 aagtgaaaga atgctgggcc tcattttttt ctgggcgggt cagcagctat aagaaaaaaa 3013261 tgaacaatca aatcgcagag ccgttaatgg gaatagtcgt tcaggggctg atcgattcag 3013321 aaatgtcagg tgttatcttc agccgcaacc ctgttaccca tgatgataga gagcttttaa 3013381 tcagcgccag ctacgggttg ggtgaagctg ttgtttcagg aaatgttacc ccagacacgt 3013441 tcattgttaa taaatcttcg tttgagattc agaaagaaat aggtgcaaag gaaatctaca 3013501 tggagtctgc ggcagaagga attgctgaaa aagaaacgag tgaagacatg cgcagccgtt 3013561 tttgccttac agatgaacaa gtgattgaat tggctgaaat cacaaaaaaa accgaagacc 3013621 tgtacggata tcctgttgat atagaatttg gaattgctga tcatcaaata taccttctgc 3013681 aagctcgccc gattacaacc attgatcagg acaaaaaagc ggcagaagaa aaacgcagct 3013741 tcatgattac cgacactgat atgaatgatt tctggcttaa catggagtct aatattgaag 3013801 gtccggtgag tccgttattt tcatccttca tcgtgccggc attggaatat ggcttgaaga 3013861 agagcatgca aaagtttccg attggtgtag ttgttgatga agtaaaactt tatcgcggac 3013921 atatttattc caaaaaccaa ggcggacagc agcctccttc tgaagactgc ggcaaagagc 3013981 ttttcccgat tttatcggag catatgtatg acatcatcaa tcacacatac ctcccttttt 3014041 accggacact ggaccagctc gcacaaactg agcataccgc agaaagcgca ctggaagctt 3014101 ttcaaaaact aaaggccttt tatctcacgg cttatgaaga gcactttaat atcgttttcc 3014161 cgcaaatcct tttaacaaac aaactgcaag cgatgtatca ggacattcaa ggagagtccg 3014221 aaaacgctca tttttacgag atgctgacag gaaaaatgaa caaatcactg gaaacggacc 3014281 gttgcttatg gctattttct gtggaagttc aggagaaccc gaaccttctg gccatttttg 3014341 aaaacaacaa gcctgaacag ctccaggaga aattggaaca aacagatgag ggaagacact 3014401 tcctgaagaa cgtccatgaa ttcttgcaag aatacggatg gagatctgtt aaaagtcatg 3014461 atctgattga acaaatctgg gtggaaaatc cgtatttcgc tctggccaat attcaaaatt 3014521 atgtccgtaa tggctatcat tttgacaatg aatttcagaa aacaaaagaa aaacgagaga 3014581 aattatacaa tgaattcttg gaaagcatag aagatcccgg tttacgcacc gaatttgacc 3014641 gctattatca atggacactg aactctgcaa atataaaaga tgatcaccac ttttatattg 3014701 acgccatgct ggatgccaag gcgagaatct ttctgctgaa gataggtgaa ttgctggcgg 3014761 aaaacggtgt cattcaagat cgggaggacc tttggttctt atatgacgac gaagtggaac 3014821 aagcgcttct tcaccctgta tccctgcaag aaaaggctga aaaacgcaga cagatttttc 3014881 atgagtatga gctggcccaa gccccggcct acctcggcac cccgacaaaa gaacagctca 3014941 aagcagctga agaaattgtc ggcgctgtga tagaggatga aaaaaacaca gagaatcata 3015001 tttttggcat tgcggcatca agcggcattg cgacaggtcc ggtgaaaatc attcgggacg 3015061 ccaatgaatt ttctcaattc gcgcctggag acgtactcgt ttgcaagatg accacaccgc 3015121 tatggaccag cctgtttcaa gacgccaaag cgattattac agacacaggc ggcattttgt 3015181 ctcacgctgc gattattgcc cgtgaatacg gcattccagc cgttctcggc acacgcacgg 3015241 caaccgaaag actgcgagac ggtgacatca tcactgttga cggaagcagc ggcaaaatca 3015301 cagttgtcag ccggtcctga tgcgtccccc tctttcttat acaagcgggg cgggtgtata 3015361 cttgtcctgc cagtatattc gtgaggtgaa acgtattgag accgacaaac aagagaatcc 3015421 ttgatgctgc catgcagctg ctcgtcaaaa aaggatatcg cgcaacgact acaaaagaaa 3015481 ttgcagaaaa agcaaatgta agtgaagcga cgattttcag gaactttaaa aacaaacaag 3015541 gactagttga ggctttgctt tctcagcatt cttcaaacag aggcagcatt ttggaacaaa 3015601 cagaagggga tttgtacaaa gacctgcttc atatcggaac ctgtctcttg gaggagctcg 3015661 aacatagaaa agatatcatt aaaatcagct ttcgtgaacc ggccatgttt caggatgtca 3015721 ttaaccacgt cactgaatat ccccaatcta tgaaacagct attggttgat tatctcaaaa 3015781 cgatgggtga gaaaggggtt attcagacag gaaatgaagc ggaacatgcc gacgtgttca 3015841 tgtcgattat cttcggttat ttcattcacc gtctccactt aggagaccgg gtcatatcaa 3015901 tgccccagga aaaaatgctg gagcatagca cagctctatt tgtcaaagga atttctgctg 3015961 attaactcct tggcataata aaaaggagga tcccaatgag ctcaagaaaa gaatgggcgc 3016021 tgatcgtctc gctattattg ggggccattc tggttcccat taactcaacg atgatcgcgg 3016081 tcgcgctctc atctatttcc catacgtata acgagtccat cgcaagcatc acttgggtgg 3016141 ttaccgttta tttaatcgtg atggcagtca cacagccgat tgcaggaaag ctcggtgaca 3016201 tgtacggcaa taaaacaatg tacttatggg gagtcggcct ttttctaatc gcatctctag 3016261 gctgcgccct ttcaccgagt ctgctcctgt taattgtctt tcgggcattg caggctgtcg 3016321 gcggggcatt gcttacgcca aacagcattg ccattatccg gcatgttgtt tctgaaaaac 3016381 gcctaccgaa agtgtttgga tttttcggac tgggcgcggg acttggtgca gcactcgggc 3016441 cttttatcgg ctctatactg attgacagct tcagctggca ttcgattttt tgggtcaaca 3016501 tcccgttcct cgccattgct ttatttacgg cattaacgat gtttcctcaa tataaagaaa 3016561 ataaatctga cgcgccgctg gatatcatcg gctctctctt gcttgcaggc agcatcgttt 3016621 ccattatcct gctgacgaaa aatgaggctc catggggata tactgtatac agtgtattga 3016681 tacttctttt tgttccgctt tttttcagaa gagaaaaacg tacccagcac cccatcattg 3016741 actttgcact gtttaaaagc tcaaccttta caaatgcgaa tctatcagtc ttgttaagca 3016801 atttgatgat gtatgccgtc ttattgatta tgccgttatt tatgacgaac caatttgggc 3016861 ttaatacatc taacagcggg atggcgcttt ctgtattttc gatcttcatg tcagccagca 3016921 actgggtggg cgcgcagctc catcacaaat ggggagccaa aaaaatcatt tttctttcat 3016981 ttgccatgat ggctggtgcg aatctattat ttttgctgtt aagcagctcg cattctgtct 3017041 tgttcctcat gctctctctt atccttggcg ggctcgcttc cggagtcggt ctgaccagca 3017101 tgcaggtttc atcccttgcc acagtagacc ccggtatgtc aggagtggca tctgggattt 3017161 tctcgacctt ccgttatttc ggaagcatca tttcatcagc cttaattggc ctgatttcgg 3017221 gatatcacac cctatttatg attctctttg ctgtatccat catcggcgtt tttgtttcat 3017281 tgggcatcaa atctgatgaa acggcacgga tagaaaaaaa ctcagcgtaa cacaaaacag 3017341 cccggcatcg catcatcctg cggtgccggg ctgcctttta tgatcccgaa gcgactgctt 3017401 cgtcttcacg gtcatccttt acgaagagga tgcccaattc atgatgttct ccttcataag 3017461 aagctcgctg gtcaaaacga atttctccat tcaaaccgat aatttcaagc tttacatatg 3017521 cacggttatg ctgaagcgct tcatagaaat cagaaacgtt cttaaccggt atgccattga 3017581 ctttcgttat gatttccccg attttcaatt ccagatcctc agccggcgta ttggggataa 3017641 tcccaagcac cattaagccc tgatcccttt tcgagaaata aaacggagcc gcgttatcat 3017701 tcactctttg ctttatggac agaaaaatac gccctaacaa agcggtacag accgctgcac 3017761 ccgcaagcgg cgtccacagt aagctcgctg caccgagaac tgcgacggca agaccgagaa 3017821 tacaaacgcg tttcgctgtg atccttatac tcgtttcagg cagcgatccc tgtacccttt 3017881 gtccaaatcc gacaaagtaa ggaatccata gaaaatggaa tgagccgccg ggaaccgtaa 3017941 acacgggcca ccagctaagg tgcgattcta aaccattacc gggcacgaga aggaacagcg 3018001 gcaaaagcca aacccggttt gccagctgct gtccgatcgg caaaccgcgg ctgcttacga 3018061 caagtgccgg tgatgttctc acatgcgcag aacgataagc aaccgctcct tcagtgataa 3018121 tcagcaaacc tagaaacaca gccacagccg gccaaacaac tgcaaatcct tgcggaaatc 3018181 tctccagaaa gggctccgcc tgatatattt gcagtccaaa acctatcagc atactcacac 3018241 tgacgatata tgcagcagac atccagtttg cgcgaagagt gaacgctgcc gctgcagtga 3018301 taacggcaat aatcgcaagt aaaccgagag gaatcgatat tccgagtcca cctaaaataa 3018361 ctgacaaaag aagacctgga atcagtccct ttgtatatgt aaatttcaga tcatcataaa 3018421 tatctgctat tcttgtatga aaggtttttc gttcccgttt gattcttaca tagccgaaag 3018481 ccaaggttat gatgataaaa aaccagaaaa gcgggtgtaa gaagaacaag cccgcgcttt 3018541 ttaacagttc aattccccat tgaacagaca ctatctctca ccgcctcaag ccaaacatgt 3018601 tactcatatt ctatcaaata ttaaatggct tggatatcct caggagagtt tatctctctt 3018661 gcgtcatcca cagcgtgaca ttcgatagtg aaaaatcctt taaatagtgg tttacatcca 3018721 catccaataa cccgctgatt agatgcatcg acctttttat atctgtcaga ttaattccta 3018781 atcgcttatg gtttttcatt aagtagttaa aataatgttt ggcgcattcc tcattaatgt 3018841 catttactga ttcgacattg gtgtaattga ccaaatatct gctgaacagc ataagaagac 3018901 ttagtgcttt tgtagctgaa aatgttacgt cttgtgttct gtcttttaat tgttccacta 3018961 attcataata tttttttttc acgcacaata cttgccctct tcaattgtga acccccattt 3019021 tctttataca gataagcacg ggccagtata agcagcagta ctggagtgct aacaagcatt 3019081 ctcgctaacg ttactcttta aatacctgtc gttcagctgc cattaacctg attactgttc 3019141 tttttagaac cttcttatat tgtatgaagt aaacaaagac taggcaactt gcaaaagttt 3019201 cattttaaat gcatattaac tcgttagaaa gtctctctca tatattgata tcgggtaata 3019261 acagtccttt ataaatgttt atttgtgaaa atttttttaa tttcttgtca aaaactcatt 3019321 ttttatgtga cttatgatcc ataatctctt taagcacaaa gaaacaggag atgaaatacc 3019381 atctccttta attgacaaat aatgatttca atgctgtttg aagctgcaaa tcattttttt 3019441 catctgattt tttcttttct atctgctgat ttaatgtctc tgcagtgcga gtgtcgatca 3019501 caccggtttt attcagcttg ttttgatcct gaaaagccat aaccgctttt ttcatgtctt 3019561 tgctgaaata gccatcctca cgtcccggat caaagctgag accttttaac aatacctgcg 3019621 catgcttgac gtcttcattg ttcatgtcca ctttaagcgg ctctttcagc tgtaagggcc 3019681 cggcggaaaa ataatcgggc tgcttaatcg caatggtcgg ttcaattcct ttcttatgaa 3019741 tccagtttcc atttggcgtc agccacttgt aaagcgttaa tttgatgttg ctgccgtccc 3019801 ccattggcac agcctgttga accgttccct ttccaaaaga cgtatcgcct acaacatcat 3019861 aatggccagc ttcctttaat gcgccggcaa gaatttctga tgcagaggca cttcctttat 3019921 ccgtaatcac attgacaggg tacgcttttt tatgggtcaa tgttgaaaaa taacgttttt 3019981 tatctccatt gcgttcagca atctgaatat acggctgatc ctttgtaacg aaatgcttaa 3020041 gaatttcttc cacactttga agatatccac ccgggttgcc gcgtacatca atgacaagtc 3020101 cttctatttc ttttttctca agctccctca gcgcttttgc aaaatcctct gcggtgtgct 3020161 cagaaaaagt agagatggca atatatccga cagaatgccc ctgtactttt ttctctgatg 3020221 caaaaaccgt ttcgagcgga atctcagctc tcttgatccg gaatgacaac tgcttcttcg 3020281 ttccaggccg ctgaatcttc attgaaacgc tggacccttt ttttcctctt atttttaaca 3020341 cagcgtggtt taaatccttg ccggccatcg attctccatt gatgctgata atttcatcat 3020401 taggcttcaa cccggctttt tccgctggcg atttcttgaa tggagaaaca ataataattt 3020461 tgccgtcttc cattccaacc tcagccccga tgccttcaaa tgaggaatca agagaatcag 3020521 aaaattgctt agctgtctgc ttgtccatgt aaacagaata aggatcattt agcgtagaca 3020581 gcattccctg gatggctccc tcgagcagct tttctctatc tactttttct acgtactcat 3020641 tcgaaattaa ctcatacgct ttttcgattt tgtccatagc tttatcccgt tcagagtcag 3020701 cttgtgccgt cgcgggaact gctgcagtct ggggcttatc catctcaagc aggttgattc 3020761 ccgcatatac accggcgcct ccgaacagca tgctccctgc tgctatcaca gccattattt 3020821 tttgattcat cctttactcc tcctgtatgc cagactgtct ttaccaaaac ctagagatag 3020881 tatatgtaaa ggatggagat ttcatgtaat catagaagaa aaagaaggca aatgaaaagc 3020941 cgtcccgaaa acggaacggc tttttcactt tatactcgca gaaacttgcg gatggaagtc 3021001 agacttcccc atactccaat tactgcgccg attgcaatca gcactagcga aacttggaat 3021061 acaaatggat tataaggaag aagagagaca aatgatcctt gaacctttgg aacgacccat 3021121 ccgatgacgt attggtaagt gctcagcacc agtgcaatcg gaatcacaga accgaatacg 3021181 cctagcagca atccttcaag gaaaaacggc cagcggataa accagtttgt cgcgccgaca 3021241 agcttcatga tttcaatttc ttttcttctt gcgaaaattg taattttaat ggtgttggaa 3021301 attaagaaca tcgccgtaaa taccaggccg ataattaacg cgattccgat gttgcgggaa 3021361 acgccgacca ctttaaacaa acggctgacc tcttcttttc cataagtgac tttataaaca 3021421 tgatccattt tttcgatctt tttcgccacg ttcggcgtat catgcggatc tgtcgttttg 3021481 acgacaaacg catcattaag cgggttttcc tgatccttca ttgtcaggga ttttccgctg 3021541 tcaccaaaac tgtcaaccag ctggtcaagc tctttttctt tagatgaaaa agtgacactc 3021601 tgaatgccct tcagttcctt aatatcgttc tgaagcttgt cctgtgcctt ctgatctgca 3021661 gtcagatcaa tcagcacttt gatttcgact tgtttttctg cattcgtggc catgttattc 3021721 aaattcagca taatcactaa aaacacgccg actaaaatca gcgtaacggt tacagcacta 3021781 atggatgcaa atgtcatcca tgtgtttctc ccgagagatt taaaactctc acgcaagtgg 3021841 cgcccgagaa ttttaatcat atgaaccata ctcccctctt gactcatcac gcacaatgat 3021901 accatcttcg attgcaatga cacgtttctt catggtgttt acgatttctt tattatgtgt 3021961 cgccatcacg actgttgtcc cgcggttgtt aatttcctcc agcgtcttca tgacttccca 3022021 ggacgtatcc ggatcaaggt ttcctgtcgg ttcatcagca atgacaacat cagggttgtt 3022081 cacaattgat ctggcaatag atacacgctg ctgctccccg cctgaaagct ggtcaggaaa 3022141 ttgtcgcgct ttatgcttca gctgcacgag atcaagcact tcaagcaccc gtttcttaat 3022201 gacagacggc tgttctccaa tcacttcaag ggcaaatgcc acattttcaa aaacagtaag 3022261 tttcggaaga agcttgaaat cctgaaagac aacacctatt ttgcggcgca cgaaaggaat 3022321 ctctttttct ttaattgtcg cgagatcttt atgattgatt aaaatttgtc cttttgtcgg 3022381 tttttcttct ctgtaaatca ttttaataaa agtagattta cctgctccgc tcggaccaac 3022441 aacatacaca aactcgccgg gatgaatggt aacagaaatc ccattgagtg cttttacgcc 3022501 gttcggatag gctttatata cttccttcat ctctatcatg aaatcaccta atcttttata 3022561 tcattttatc tatcacacgg tcatactctt cgaatgcatt cgacaattta tgacccattc 3022621 atttgtaaaa agatgaaaaa tctgaaagtt ccctttttca atacacttca ttatacgtca 3022681 aatttagaca taatactatt acagtttctt ttcattcata ttgtcaaggc ataaaaacat 3022741 ccttgccagc actcggcaag gatgttttta tcttactttt tttctgacag ccatttggca 3022801 ataacagcgg cttcgttatc atctacaagc ccctttggca tattgccgcg gccgttttta 3022861 ataatgcttt caattttgtg ttcatcgtat ttgcctccga cctcttggag attaggccct 3022921 gacacacctt ctaaatcctt gccgtggcag cctacgcagc tttgctgata taattcttcc 3022981 ccttcagatg cagtggcttc cgtcttgctg ccagtgtctg tcttctcttc ttttgcatcg 3023041 tttgatccgc aggcagccaa cagaacagaa agcgcaaatc caatcattag tatcgataac 3023101 tttgatttca tgttgagaag cacaactcct ttacgatctc ttccatatta taacctcgtt 3023161 taagcgcgtt tgaaaccctc gcccagcacc tcgctcgcgt ctgctacaat tacaaaagct 3023221 gactcatcaa tctgtttgac gatttgtttc aatttggtga attcagtttg cccaaccacg 3023281 cacattaaaa tcggacggtc atcgtcagta tatccgccga ctgcagaaat ttttgtcacg 3023341 cctctgtcaa tcttctgtaa gacagcctcc ttgacagcct gctcctgctt tgtaatgatg 3023401 agcgccattt ttgaacgatt aaagccgact tgcacaacat caatggtttt gctggacaca 3023461 tagacgccaa gcatggcata taagccttgc tcaatattaa atacaatcat agccgtaaca 3023521 acgatcattc cgtcaatgat ggcgagacac ttccccaatg acagaccgga gtacttatga 3023581 atgatctgtg cagccaaggc tgtacctccc gtcgaacctt tccctaagta cacaatacca 3023641 attccgatac ctatcccgac accgccaaaa atcgccgcca ggagttcatg atgagtggcg 3023701 ggctgaatat cccttgtcag aaacactact agcggcaaaa acacagaacc tgcaagcgtc 3023761 tttagtccaa atttcccgcc gagcaaaatg acgccagcaa taaataaagg gatattaata 3023821 atccactgta catacgctgc ttcaaaacca tatgattgta aaatcgtact gatcccgctg 3023881 accccgccgg cggcaatctt attcggaagc aaaaatacat taaaggacac ggccgtaatc 3023941 gctgctccta tcaatatgta tacataatcc cgcaaaatcc acaatgtttt attccgtacg 3024001 tccatcatat atcctccgtt tcttccaatg ctctccgata gcattttaat ccttccctga 3024061 ttagatgtaa ataacaccca aatacagtgg taatatgcta aagcagcagt gaaatcaagg 3024121 atataagaaa taaaaaaaca cacccgtatg catcaggtgt gtttttcagc ttatgaaagc 3024181 ttagaacgca ggtaggcatc aataaacgta tcaatgtcac catccattac agcttgaacg 3024241 ttccccattt ctgtattggt ccgatggtct tttaccatgg aatacggatg gaatacataa 3024301 gaacggattt ggctgcccca gccgatttct ttttgttcac cgcgaatttc atccagctct 3024361 gcctgctgct cttcaattct gcgctgatac agcttggcct tcagcatttt catggctctt 3024421 tcacggtttt taatttgtga gcgctccgtt tggcatgtca caactacgtt cgtcggcaag 3024481 tgagtaatcc gaacggctga atccgtcgta ttgacgtgct gtccgcccgc gccgcttgca 3024541 cggtacgtgt caactttaat atcctccgta cgaatatcaa tatcaatttc atcgttaaat 3024601 tcaggcatga cttcacatga aacgaaagat gtgtggcggc ggcctgatga atcaaatggt 3024661 gagatccgca caagacgatg aacacctttt tctgctttga gatacccgta agcgttgtgt 3024721 cctttgatga gcaatgtcac tgacttgatt cccgcctcgt cacctggaag gtaatcgaga 3024781 gtctctactt taaagccgcg gcgctctccc catcttgtat acattctaag aagcatagag 3024841 ccccagtcct gtgactctgt accgccagca ccagggtgca gttctaaaat cgcgttattt 3024901 ttatcatacg gctcgctgag aagaagctga agctcaaact cattgaactc ttttgttaat 3024961 gactttagtt ctttttcaag ctcaagctgg agatcagtgt ccggctcttc tttcaaaaga 3025021 tcatgagtca tttgtaattc ttcgtgggat tcattcaatt ttttatacga attgacataa 3025081 tcctttaaac cgtttgcttc atttataacc gtttgagctt tttgctgatc attccagaat 3025141 tccggatcag ccatttgttc atctagctca gcaatgcggg cctcctttga ttcgaggtca 3025201 aagagacccc ctaaagtccg ctaaacgaga agccatattt tcgagctctg ctctaatttc 3025261 tgataattcc atttcattca cctcattaaa agatccgcag gcgcctgcag gcgccgcggt 3025321 cagtaaactt gccggggcga actattcagt acggccgcag caatttttat attttttccc 3025381 gcttccgcag tggcatgggg catttcgtcc gatatcaacc actttgcgaa ccggtgcttt 3025441 ctttgctttt ttgttatcgt cgccttcttg cggctgatga gctgttgttt gaccttgtac 3025501 aacctcttca cgctccagat tgttttcaat ctcagctttc atcacaaatt ttgcgacttc 3025561 gtcctcaatt gattcaatca tatgctcaaa catcgcaaaa ccttccattt gatactcacg 3025621 aagcgggttc gtctgcgcgt aagcacgaag gtgaatccct tggcggagct gatccatcgc 3025681 atcaatatga tccatccatt tagaatcaac ggcacgaaga acgataactt tttcgaattc 3025741 gcgcatttgc tctttgccga attgctcttc cttctcatta tattttgtga tgatgcgatc 3025801 cataatgagc tcaagcattt catccggttc tttgccgaag atatcgctct tctcaagtgc 3025861 accttcatca agataagttg tgttgataag atcaactaga ccgtcaagct tccactcctc 3025921 aggaagctct tctcttggcg tataggctgc aattgcgcgt tcgagagaag acttgatcat 3025981 attttcaacg atttcacgca ggttttcaga gtcaatgact tcaaagcgct gcttataaat 3026041 gacctcacgc tgctggcgga gaacatcatc atattgcaga agctgtttac gcgaatcgaa 3026101 gttattgcct tcgacgcgtt tttgagacga ttcaaccgcg cgagatacca ttttgctttg 3026161 gattggagta gagtcgtcca tgccgaagcg gtcaagcatc gccattgtcc gctcagctcc 3026221 gaatctgcgc atcaattcat cttccataga aagataaaat tgagtaatcc ccgggtctcc 3026281 ctgacgtccg gaacgacctc gaagctgatt gtcaatccgg cgtgattcat gtcgttctgt 3026341 tccgactaca gcgagcccgc caagctcttt tacaccttcg ccaagcttaa tgtccgttcc 3026401 gcgccccgcc atgttagtcg caatcgtaac tgcgcctttt tggccggcct cttcaatgat 3026461 ctgcgcttca cgttcatggt ttttggcatt taacacttga tgcggaattc ctttgttttt 3026521 aagcagctta gaaatcaatt cagatgtttc aacggcaacc gtaccgacta gaacaggctg 3026581 tcccgtcatg taacgctgtg cgacatcctc cgcaactgcc ttaaactttc cttccatcgt 3026641 gcggtaaatt aaatccgggc ggtcatcacg gacaacaggc ctgttggtag ggatcgtgac 3026701 aacctgcatg ttgtagatgt tgcggaattc ttcttcctct gtcttagctg tacccgtcat 3026761 accggcaagt ttttcgtaca ttcggaagta gttttggaac gtaatcgtcg ccaaggtcat 3026821 gctttcgttt tgaatctcaa gcccttcctt tgcttcaatc gcttggtgaa gcccctcact 3026881 gtagcggcgg cctttcatca gacgtcccgt gaaggaatca acaataacaa cctgtccgtc 3026941 ttccactaca tagtcaacgt ccttttgcat cgcaacgtga gcttttaagg cctggttgat 3027001 atggtggttg agcgcgacat gcttcacatc aaagaggtta tcgatgccga atgctttttc 3027061 cgccttcgtc attccttctt cagtaagctg tacagctttt gttttgatat cgtacgtgta 3027121 atccttctcc gcttttaacg tgcggacaaa agcatttgcc tgtacgtaca gcttagtgga 3027181 ttttgcagct tgtccagaaa tgataagcgg tgttcttgct tcatcaatta aaatagagtc 3027241 aacttcatct attaccgcaa aatgaagcgg gcgctgaacc atctgctctt tataaagaac 3027301 catattgtca cgcaaatagt cgaagccaag ctcgttgttt gtggagtaag taatatcagc 3027361 ggcataagct tcccgttttt cgtcttttga cattgagttt aaattcaaac cgacagtcaa 3027421 accgagaaac tcgaaaattt tccccatttg ctcagcgtca cggcttgcca agtattcgtt 3027481 gacagtcacg acgtgtacgc ctttaccggt taacgcattt aaataaacag gcagggtaga 3027541 cgttaatgtt ttcccttccc ctgttttcat ttccgctata tttccgtcat gaagcgccac 3027601 gccccccatg agctggactt taaacggaaa catgcctgtt acgcggcgtg aagcttctcg 3027661 aacaacagcg aaagcttcaa caagaagatc atccgttgtc gccccttttt caagacgctc 3027721 tttaaattca attgttttat gtttcaatgc gtcgtcagag agattttcat agtctccgcg 3027781 aatcgcatca atatcgttag caattttttc gtatctattc agcgtacgtt ttgttggatc 3027841 aaacatttta tttaaaattc caagcattta taacgctcct ctatcatcac acgcctattt 3027901 tagaggcatg tataaataat ttactagtcc atgtatacct ctcattatca tatcatacct 3027961 tttgttattt ccaaagaatt tgcaaataag aaaaacaaaa accttccgcg gacatcacgg 3028021 aaggcttctc ttcattattc agtcggttca attaagccat atttcccgtc atttctgcgg 3028081 tacacgacat ttgtaaggtt tgtttccgca tttgtgaaaa caaagaaatt atggccgagc 3028141 atattcattt gcaagatcgc ttcttcacta tccatcggct ttaaattaaa gcgtttctga 3028201 cggacgatgt ccaagctctc ctcctcttct atgtcatcct gaaccgcaat atctgtatca 3028261 gagccaagac cgtttgccaa taaatatttt ggagagccct gctcacggaa tttacggttt 3028321 actttcgttt tatgcttacg gatttgacgt tccagtttgt ttgttgcgag atcaattgcg 3028381 ttgtacatat cctcgttatg cacctcggac cgaagcgcca gatctgtcat cggaatcgta 3028441 acctcaacct tagactcctt gtcattgtaa aacttcaagt tgacgttcac atcagcatcc 3028501 acgctatggt caaaatagcg ctccagcttg ccgatcttcc tctcgacatg atcctttaac 3028561 gcgggtgtca cttcaatatt ttctcctctg atgttatagt tcatcaaaga acgcctccct 3028621 tttattaagg atatgtatct atttctcttt taccctttac aattcctgct gaaacataaa 3028681 tcttttgtga aaattcagtg aactttgtcg aattttgttt gtatttgctc tgttattggc 3028741 ggctgctaag cttttgaatc aaacagtttc attttgctac ttttcggcag ctcagcttta 3028801 attgatttgc tgtaattgaa gttattttcc ttaggaacca gcatatcgta cgaaatagag 3028861 atgaattgca gcgcgtctct tgtcagctgc ctattcatct catttacttt tttcagacgt 3028921 ccgagaactt gagaaagaga ttcgtatagt tgttccagct cttccttttc actgcctgag 3028981 gttttggcga tacatgcgga aatagtatta ttttcgctat atccgagaaa ggccgaagtt 3029041 gttttgatcc ggtcatcttc tgtctgcgtg attgcttgaa tatatttttg ctcttttgtc 3029101 aaaatgttag aaagctcttt tgttttgccg gctttgagcg cttccgtctt ttcttcagac 3029161 agcgtgagca ggtgctcatg cagaacgcaa agtcgcttca attgttcaat aattgccttc 3029221 gctgacatgg gctttctcct tttttattgc tttttataaa aattaatcat atttttcgca 3029281 atatgatttg cgtctacttt gtatgacccg ttttcaattt gcgctttaag ctgcgcaatt 3029341 ttttcctgtc gtgaaccagt gactgcgtcg gatgcatgtt gcatttcttt agcctgtgat 3029401 gaaatttcaa ttttatcttg aggttgtgca acagtttttt gcaccgcttg cttatcataa 3029461 tttttttgat atggattaac ggattgtgtt ccaaattgat tgattttcat aggattcctc 3029521 tcgctttccg ttgcagtctt taaacaatct taaccctttt atcgactgcg ttttcagtta 3029581 gtttagggaa tcagctgttt ttggtattat aggcatagta tgtgtctttt ttactatttt 3029641 ctttctcgat tttcagagca tcctcgtggt tcaaatgatc catttgatcc ttaatatcag 3029701 actggcaagc cttgcagaac ttgccttctc taatcgatgt cccgcacctt tcacaagggt 3029761 atgccaaatt aggaagatga gtgatctgaa ttcgcttctg cctgatgaat ttcaatatca 3029821 gctcttcttc cacacctgtt tcctcagtta tccggctcaa agttgattgc cggttttcct 3029881 gttttcttaa aaatttatag acagtctcaa atgatttttc ttcttcctta atacacgcct 3029941 gacatacggt ttgcagcttt gtttttaaaa ataaagcatt gcatttcgga caattagcca 3030001 gttctcccat ctttttttct ccttattaga taatatgcct gtgtcaattt ctagtgatta 3030061 tatcggcata aaaacagaat catttagctt ctgatcaagg taaaagatga cactgaagcg 3030121 gcttttcctt tttctaataa gcagcgggct gcgaagtgca aggtggcgcc tgttgtataa 3030181 agatcgtcta ttaaaatgat attcatacct tctgctgaat tattttttgt atcaaaaatg 3030241 cactctgaca gcaggcgttc tgttttcttt ttctttgact gtttctcatt attcaggcga 3030301 atgaggggat ggtgggaagg ccggtctaaa cattctgcca agagatgtgc ctggttaaat 3030361 ccgcgctctt cttcccgttc cttgctcagc ggaataggta caagaacaaa atgcttatcg 3030421 gggtaaacct tagaaaaggt tgaagaaaaa tcacttttaa atgcatttat gatttctgca 3030481 tctcctctaa atttaaaacg ggagagcgtt tctttcatca tatcattata tgtgtaaact 3030541 gaacggtttt gacgcaatag caaactgtct ctgatccttg ttctccacac ctcgcaatcc 3030601 ctgcatacgg catgaacaga ttgaggtctg ccgcacaggg ggcagatatg tcctgtgatt 3030661 ttctttaatt tgcttctgca agaataacaa accttttcat caggctttag taaaaaaagg 3030721 gctctccatg taacatcttg agaaaattgc gaatcacata ataaacagat cagtttatga 3030781 atgcctcctc ctgcttcgtt tgacataaat cgcttggact ctctgaaact actgcagcag 3030841 attcagccaa aatgacaagc attgctgtgt ttttttgttt atctaccagc tcagctttcg 3030901 tatatgcgat ctttttaaaa tcagtaacgt aggatggact cactttgttt aaagaaagtg 3030961 ccaatacatc gttttggcat acttggcaag tacaggccat atgaagctgg tccatatatc 3031021 ggtcgagcag ttctttcatt acgatttctt ttgaattgac aagcattttt acagctcctc 3031081 atcatcggtt atatgagtat actgtaccac gttttcaaat aatggctagt ctgtacattc 3031141 aacttttgct gccaattcat tcatttcttt tatatgcttt cttgcatcga gcatactctt 3031201 tgttttgccg aagtgaaagt aaatgacatc gccgtccgca tattctttat gccggccggt 3031261 tcttcctgca atttgaacaa gtgcgctttc cgtaaagata gacgattccg ctcctagtac 3031321 acccgtttgc accttgggga ctgtgacgcc tctttccagt attgttgttg tgattaatag 3031381 atcgagctga ccatctctga attgctgcac tttctccttt ctatgcttgt cttccgcgtg 3031441 cacagatgcg gttcggcaat gaacaccttt aaagcacgca gcagcctttt ccagaataga 3031501 aacggaagga acgaataaaa aaacaggcct cccttctttt acatgaaact ctatccatct 3031561 tttcaccgct ggcggaattt tatttcggtt taatttcttc ttccagtttc cacaccatac 3031621 aaagcgcggt tcgggtaaag gtttccggtg gtgtcttgcg gggatgcgaa ctgaatgtaa 3031681 ctgtccgttc agtgcttttc tttttaattc tttaggaggt gttgcactta aataaacgag 3031741 ggtgctgttt ttctttcttg ctttttgaac agcgaattga agggtttgat cagcagaata 3031801 tggaaaagcg tcaacttcat caatgatcat aacatcgatt gcatctttat atcgcaaaag 3031861 ctgatgcgta gtggaaatca taagcggaga tagccgccct ttgtcatcgc ttcctccgta 3031921 aagcgctgaa atgtcagcac cctgaaaggc agccttgagt cttggagcaa gctctaatac 3031981 aacatcggtg cgaggtgttg caatacatac acgcagtcct tgatttaacg ctgattctat 3032041 accaggaaac agcatttctg ttttgccagc gccgcaaacc gcccagatga ggagctcttc 3032101 tttttttgat attgcttcaa ttaaaacatt ggcggctttt tgctgtccgc ttgaaagctt 3032161 gccatcccat gtcagcttaa tagacttcca gtttgattca ttttcctctt tccatgaata 3032221 taaaggaacc tcctcactca ctctgcccat catgacacag gaacggcaat acagcttatt 3032281 ctttccagat gagtgataaa aagaaaaata ccgctgatca gtttgtccgc acctattaca 3032341 tctatatctc cgtttattta tggatataga attttcagca gtgatatatc cattcttgat 3032401 atgccattca atcatctcat cggaaaatga gagctcagtc ctgagcaaat gacggcttcg 3032461 aagcgtctgc tgcaattctt ttgaaaagga actgtttttt tcaactggca cattcacata 3032521 gcacgcctcc tttcgaaaca gtatgcctga atgaatattt tctgtccaac tattaaaata 3032581 agaatataaa aaaatctccg ctctaaaaac ggagatttgg ccttatttaa aacaccagca 3032641 aattcctaac gcaccttcac ccaaatgagt gccgattacc gcgccaaaat agctgttata 3032701 aaattcaaca tgaggatatt ttgcagaaag ctcttcaatg attttcgctg cttcttcctc 3032761 tcgattagcg tggataacag cagctcgcat aggcaaccct ttactcgcat cttcgtctaa 3032821 aagctcataa attcgcgaaa ttgctttttt acgtgtgcga atcttctcaa aaggcacaat 3032881 taccttattg tcaaaatgaa ggataggctt tacctttaga agactaccaa tgaaggcttg 3032941 ggcgctgctt aatcgcccgc cgcgctgaag atgggctaag tcatctacca taaaataagc 3033001 tcgaactgtt tttttcattt cttccagttc ttttataata tcttccggcg atgatgctcc 3033061 gtttttgatt aattcagcag ctttaagggc ataaaagcct tgagccaagc agctgatctc 3033121 tgagtcaaat ggatacacat caatattgtc gaccatcgaa tcagccgctg ctgcactgct 3033181 gaatgttccg ctgatcccgc tggaaagatg gatactgata accgcatcat aagacttgcc 3033241 aagctcttca tacaacgcaa ccagctcgcc gattggcggc tgagaagtcg tcgggagctc 3033301 attatgtttt ttcacttctt cataaaagct tttccagtcc aactcaattt cttcacggta 3033361 agtctcctcc ctaaaaacaa cctggagagg gatcatatgt atctgatgtt gttcacgcat 3033421 ttctttcgga atatatgccg tgctgtctgt tacgactgca atattcatag cttcgatacc 3033481 tgccttattg ctttataact ctattgtaag ggaaacggca gcctaaaaaa agacctgcct 3033541 agtaaaaggc aagtctccta ttatactatc tcatttctac ccagccattt ttaatggcga 3033601 ccacaacggc ttgcgtccgg tcgtttacat tcattttttg taaaatattg ctgacatggt 3033661 ttttaacggt tttctcactg ataaacaatg attcaccaat accgcggttg ctttttccgt 3033721 ctgcaagcat ctgcagcact tcacattccc gcctagttaa aatatgtaat ggtctgcgga 3033781 tttcagggta aacctcatgt tgagggtgtg cagaaactcc gcttgttgca aggcggcgga 3033841 attcgttaac gaggttgtga gtaaccttcg gatggaggta agatccgccc tcagccacta 3033901 ctttaaccgc ttcaattaat gtatcagcat ccatctcttt cagcagataa cctcttgcac 3033961 ctgttttcag ggcatgtgtt acataatttt cgtcatcgtg aattgataga ataattactt 3034021 tagattcagg atacagctct acaagctgtt ttgtagcttc cacaccattt acgtttggca 3034081 tattgatatc catgatcaca acatcaggat gatagtgctc aacaatacga gccgcttcgt 3034141 ccccgtcatc accttcggct accacttcaa aggtaggttc aaaatccaat atccgtttaa 3034201 caccttcacg aaataactga tggtcgtcga taataacaat gtttacttta gtcacaagcc 3034261 acgcctcctt gtattattgt tctatatact ctagcattcg gtcaatatgc cttttggctc 3034321 tattttacaa atcatagtca aagagataac ggaaccttaa tcataataaa tgtcccaaga 3034381 cctattttcg aatctattgt catcgttcct tccaataaat ctactctttc tttcatgccc 3034441 agcaagccga atgatttgtt tttcttctct ttcgcttcct tcaggtcgaa ccctttaccg 3034501 ttatctttta tcattaaaat cacaaaatcc tttgtgatct caactttgac tgtaatttct 3034561 tcagattcag aatgctttag cgcattagac acagcttcct gtgcgagcct gaagagcgca 3034621 acctcaaact gaggcgctag cctctgatcc tctgtttctc caatgcactg aaaatgtatt 3034681 ttgaccttcc cgttatattc ctcggttgta tatagatatt ttcttaaagt tggaatcagg 3034741 cctaggtcat caagggccat cggtcttaaa tcatatataa tccttctcac ttcgtaaagg 3034801 gcattccgaa cattttggcg gagattttta atttcttgga atccgtcctc tgcgccccgg 3034861 tcacggaaaa tccgctcgat taattccgat ctcatcataa cattcgccag catttgagcg 3034921 ggtccgtcat ggatttctct tgagactctt tttcgctctt cttcctgcgc ctcaataatt 3034981 cttaagccga aatcctgttt tgcctgagca tcagcaagaa gcagtccaac ttcgcgcaaa 3035041 tcctgattca agtagttgag cacaactgta atttggctta ctaatgattc tgaccgctca 3035101 atgatttcct gaagccctag caatctgcgc tccaaatcgt cccgccgttc gcgcaattgc 3035161 ttctcacgct gctggatcat cgtcaattct acctgcagct tatgggcttt ttcataagca 3035221 ttgcggattt cctcttcact gaatctatga aaattacggc tgacctcgga taaacggttt 3035281 ctcgcatggc gagtttgcac ttcaagttta tcgccaagct caatcacttc atacacctgc 3035341 tgtttaattt gtttcagttc ttcgaccagc tgttcatact gctggcgtga ctgctccccg 3035401 atttgaaaaa cctcgtcctt gctcccgtca acggttttca gcatcttcat caaaatagaa 3035461 tccagcactt tggaatccat ctttgtttta ttcataattt ccctccgtca cggcgttgtc 3035521 atatattttt attataaatg taattgatct gcaaattatg tcgaattata atgaaagaat 3035581 gcgtatattc tagaaaaaaa catttttata tactatctac tctttatgat accaaaatac 3035641 gcacaaaaat tctaaagact gtacgaattt gtataggcag tcttttatgc ttagcaggag 3035701 ggtcagctag catgctgcac agctatttta ctgtgaaaga agcgggagaa cacgagattg 3035761 ttatagaaaa atcgcgtttt atctgtcatt taagccgtgt ttctaccgaa caagaggcac 3035821 aggaatttat acagaaaata aagaaacagc actggaatgc gactcataat tgctcggctt 3035881 atgttattgg cgagaatgat catatccaaa aagccaatga tgacggggaa ccaagcggta 3035941 cagcgggagt gccgatgctc gaggttttaa aaaaacgcag gctgaaggat acttgcgccg 3036001 tcgttacacg ctacttcgga ggcattaagc ttggtgctgg cggattaatt cgcgcttatg 3036061 ggaaatcagt gtctgaagga ttaaatcata taggtgttgt agaacggaag cttatgcgaa 3036121 tcatgcatac ttctgcagat tacacatggc ttggcaagat tgaaaatgaa ttaagggagt 3036181 cacaatttct gttaaaggaa atccattatt cagaaaatgt tgaattcgaa acatacgtgg 3036241 aagaaaaaga aaccaacgct ttttctgaat ggatgacaga actgacaaat ggaaagagtg 3036301 atattaaaga gggagagttg acgtatcttg aaaaagccgt caatcacata aaggagactg 3036361 aataatggct gaacgcgtta gagtgcgtgt gcgaaaaaag aaaaagagca aacgtaggaa 3036421 aattttaaaa agaataatgt tattgttcgc ccttgcacta ttggtagttg tagggcttgg 3036481 cgggtataaa ctttataaaa ccattaacgc tgcggatgaa tcgtacgatg ccctatcccg 3036541 cgggaataaa tcaaatcttc gcaacgaagt tgtagacatg aagaaaaaac cattttctat 3036601 tttatttatg ggaatagagg attacgcgac taaaggacaa aaagggagat cagactctct 3036661 tattgttgtt accctggatc ccaaaaataa aaccatgaaa atgctgagca ttccgcgtga 3036721 cacacgtgtg caattagctg gtgacacaac gggaagcaag acgaagatca atgccgctta 3036781 cagcaaaggc ggtaaagatg aaacagttga aactgttgaa aacttcttgc aaatcccgat 3036841 cgataaatat gtcacagttg attttgacgg atttaaagat gtgattaatg aagtcggcgg 3036901 tattgatgtt gacgtgcctt tcgatttcga tgaaaaaagt gatgtagacg aaagcaaacg 3036961 gatttacttc aaaaaaggcg agatgcattt gaacggcgaa gaagccttag catatgcccg 3037021 gatgagaaaa caggataaac gcggagactt tggccgtaat gacagacaaa aacaaatctt 3037081 aaacgcgctg attgaccgca tgtcaagtgc aagcaacatt gctaaaattg ataaaatcgc 3037141 agaaaaagcc agcgaaaacg ttgaaaccaa tattcgcatt actgaaggtt tagcgcttca 3037201 gcagatttac agcggcttta ccagcaaaaa aatcgacaca ttgagcatta caggttctga 3037261 tttgtattta gggcctaaca acacatatta ctttgaacct gatgctacaa atctcgagaa 3037321 agtcagaaaa acgcttcaag agcatttaga ttatactcct gatacaagca ctggcacttc 3037381 cggtaccgaa gacgggactg acagctcaag cagttctggc agcactggca gcactggcac 3037441 aacaactgac gggacgacga acggaagcag ctattcgaat gacagcagca caagctcaaa 3037501 caacagtaca acgaattcaa caactgattc atcctattaa aaaatgcccg gtccttttag 3037561 aggatcgggc atttttgcgc agaaaaaaac tccggcacat aagccggagt ttttaattcc 3037621 ttttcaccag ccgtttataa aactttgtaa acggcttaaa tttttcattc acgagtcctg 3037681 tcacttctgc tatgatttgc ataaaaataa tcaaaatgaa gataataaac aaagaaagcc 3037741 aaattgtggc acttttaagt acaatcgcac tgatactgaa aataaatcca attaaataaa 3037801 taactaagac cgacatccga tgtgaaaggc caaaggccat cagtctatgg tgaatatgcg 3037861 acttatcagg cgctgaaatc ggctgtttgt ttaatattct tctgatgata gcaaatgttg 3037921 tatcaaaaat cggtacgcct aatataataa tcgggataac gatactgaac aatgtgacac 3037981 ttttatacag gcctaataat gaaagaatcg agatactata ccctaaaaac agtgatcccg 3038041 tatctcccat aaagattttt gccggatgga agttgtaaaa caaaaacccc agcgtgctgg 3038101 caataacgac taatgagagt gacagaatga gcacttttcc gccggatagc gccatgacag 3038161 caatcgttga caggccgata acagaaagac cggcagcaag gccatccaat ccatcaatca 3038221 ggttaattgc gttcgtgatg ccgacaatcc ataataccgt cagcggataa gccatccatc 3038281 ctaactcaaa tcgttctgtt aaaaaaggta ctgagaaaaa gtccattttt aagccagtgc 3038341 ttacaatcat aatggctaca cctaattgaa tcaaaaactt aacttttgca cttaattgat 3038401 atttatcgtc aagaatacct aacacaataa tgatgaatgc tccgactgta attgccgtca 3038461 tccttgtttc tgtgtaaata ccggatgcaa gcacgcctgc aaccaccccg ataaatatgg 3038521 ccagcccgcc catgcggggc atgattttgt catgtacttt tcgattgctg ggctggtcaa 3038581 ctgcacctat tttaatcgca atccttttta cgattggggt tatgattaaa actgtcagca 3038641 gcgagacaat aaacgcaaca acaatgcgaa tcatgcgttc gtcaagcata aagaagtctc 3038701 ctttggaatt aaatgaagtc tttatttata tagagaaccg ttccttccat tataccttct 3038761 ccttagttat tataacaagc ttcatcaaaa agaaacacgt ataatcaaaa aacgcgcatc 3038821 ccaatttata ggactacgca tgtttttgaa tccctgtata tttcataatt tgtctaaata 3038881 agcaattcca atcttgtgtc cgggcgatgt ttcggcgcat ttctttatag gtctcgtctc 3038941 cgttttgacc gagaactttt tcacaagcgg ctataaaatc aatcggatga tcgccctcta 3039001 catattcgta tacatacggc ttttgcattt ttgaggttga cggaagatta gtgcctacaa 3039061 caggttttcc tgccgctaaa aattcaaata gtttcagcgg aaacacagct tgattatacg 3039121 gtgattgttt atatggcata atgccaatgt cgataagctc catataatga ggcacttctt 3039181 ttggatctgc cggaccggtc catatgacat tgggaagcct cagcagctct tgaaacgaaa 3039241 catcaccatt ggtggcatcc gggccaaccc ataaaaatgt ccaatcaggc ttttgcagtg 3039301 ccgcttcttt aatcatttta aaatcgagct tcggtttaat cccgccaata aaacctaaca 3039361 ctattccttc tctcccctgc agtatactgc gatcgggagc ttgtttattt gcagaaaaca 3039421 gctcatactc cacaccgttt tccacagtat gaaccttttc tcgtcctgca gtcagttttt 3039481 tgtctacttc cttgtgaaga taatctgatg aacaggttat tgaatctgct cgttgtataa 3039541 ttctcagctc tgccgattta atgacttttc gccggaattc agacagcaga tttgatcggc 3039601 cgctgatcgg cgcagcccat aggtcactgc agtcataaat gacctgatcc caagaataca 3039661 gcgaagacag cagcgggaat ccgggaaacg tgtaccataa acagcagcgt tcaccgtttg 3039721 cagaagcagg tgtaagctca tcgagtaatg gggagagctt atgtctgtaa aagacatctg 3039781 tatatcgtcc gaaacgaaac atttttttct gcagcaggtc tttgacagcg aattgcctga 3039841 tgccagaatg gacttcctga aactctttcc cttgggcacg cggagccgga catacccaaa 3039901 taacttcctt cgtttcctcc tgagcagcta aaaattctgc cagccggtgc cttctgtatc 3039961 tcaattggtc ttttccccat tcagcagtgg caacgatgac atgaatgatt gcttcttttg 3040021 tttccacctt catcaccttt tctctctgtt tgcagctata atcttttttt caccgcgttt 3040081 tttgcatatt gaacaaaaca ccatgttgct ttcataaaat gaagccgttc gatctccctg 3040141 tagacaaacc acgttttttt cgcagccttc catttgttgc tggaaattga attattgaca 3040201 agccgatatt cagccaggca ttcattcatt ccataggcag taaatccttt ttttaaaaga 3040261 gacagccatg tggctaagtc ctgtctcgtt ctgatattcg gcatttggat ctgtcccgtt 3040321 tgctccctgt caatcatcac cgtcaagcag ccgataattg tatttttcag ggcgtcatcg 3040381 tacgtcaggc tttccggcgc atgaataaat ttatcgagcg gggtcccgtc ctgcgccatt 3040441 aagctgtagc ccgtgaaaga gaacgcacag gagcgctcca tcataaactc aagctgcttt 3040501 tccagtttgt cttttttcca tttgtcatca ctgtccaaaa atgctacgta gcgcccttga 3040561 gcgcgttcca acgctttgtt gcgagcaacc gcagctccgg agttctcttc cagatacacc 3040621 acatgaattc tttcgtctat tttttcatac tgctgtaaaa tgtcgcgggt cccatccgtt 3040681 gagcaatcat ccacgataat catttcccaa tgaggatggc tctgatctaa taccgaatga 3040741 accgtgtctt caatatagtc acgcgcatta taggaaggtg taatgacaga tacgagaggt 3040801 ttccaattgg tcatgatcac atctccatcg tatgatttta aaaggattct ctgaaaaatt 3040861 caggaatgac aacgaacata aaggcaatcg taaggccaat cataacgccg agaactgctt 3040921 tctttttcgg agacataccg ccgcctgctg tctcacttac ggtttcggaa tcagtaacac 3040981 ttgccgcttt caggttaagc tgtgtgtttt tgagttcata taaaaatctc tctttatcca 3041041 ctttggaatc ctcgctcacc gactcgcctt caagcgcgtc tatgctgctg cggatgacgg 3041101 cttctctttc tgcatacagc ttttgatcgt ttttgaggaa ggtggaggat atggcgttta 3041161 agacagattc cgttctatcc ttatcctcgt cactatagct taaagtcagt aacgatttgg 3041221 attccgtatt gattgtaagc ttctctttga tctctgctac atcttcatcc ttttcatcag 3041281 gaagcgcctc cttcaaaaag gagtcgctct ttaatagaag cggaatctct tctgtgctgt 3041341 tataaaccgg atgatcatag ctccccacag ccaaagtatc ttcagctgta tagctctttt 3041401 gatcagcgat ctgtgacggc aggatatacc ccgccgcacc taatataatt ggcaccgcta 3041461 tgatccaaat gatatttttt tttatgcgac gggctattct tatcaatata tcgttcatat 3041521 aagtctccct gctttttgta gtctgtttat ctgtacatcg gctcaggcat ttgtctggat 3041581 cgccttaaca cattcacggc ggcgatgacg agcgccataa acacccaatg gaaaaataaa 3041641 tttgaaacag agcttgggct gatacttgat accaggaaac tgaccatagc ggtaataagt 3041701 ccttctgtga tcagttttga ctgattttct aattttcttt cataaaactt gtaaagcacc 3041761 catatgaggt aggcataaac ggacaaatat cccagcatga tgaacaaacc aaaattagca 3041821 agaatttcaa caagccagtt atgcacctct gccacattgt cagtatcata tacagcataa 3041881 tgctcaagat aataggatac atttcctgcc ccgactccga atccgtatga atcaaggaaa 3041941 aaatgccaag cgtttttcag cagatttgcc cgagccacat ttgatggaag cctgtcatga 3042001 aatgaatgca gcgtctgcgg ggccagaaac agctcccaaa actttgaata gattttgctg 3042061 gcgaaaagaa ctgcgaaaag agcaattccc gccgccgaca gccatatagc cattctcttt 3042121 aaaacaggcg gcaatacaat gaagatgtag acagcaatac ctgcaaaaat gcccagaagg 3042181 ctggctcttg aaccagtggc aaaaattaaa tacaacgcac agagcgagag cacaaggcca 3042241 attgccttga tgtatccatt cttaatgttt ttcatcatcg tgatgtaaaa aaagaagctg 3042301 atggataaaa aggtcgcaaa gtcattttga ttaaaaaaga ccgatgtcgg ataatgctgc 3042361 ttgtactccg gtccgctgta caatgtggaa ctcgcaagat gatggtgggt gatatgattg 3042421 taaaaaccaa tgatcatcag aaataccgtc atcaccagcc aaatggcata aacaatcatc 3042481 agccgctcca ttttttgcac gtacatgaca ataagataaa tgaagaagat ccccattgcc 3042541 aataaggcta aatacttgag gccaactgtt accgacttgg cccacagcag agaaacaagg 3042601 ccatatataa accaaaaggc gaaaaagagt aaaatccctt ttacttgcag cccatgccat 3042661 ctttcaatat gggttcgatt ccgaaccatg ccgaaaatat gaaggcaacc cgctgcaatg 3042721 agcagaagcc ggtaaaggaa caaactgaaa aatccaagat gaatggcaaa aaatgcatta 3042781 tttaaaaaag tgcaggcgat caaaatatag attacagcca taaagagccg ttcttttgtt 3042841 gtaaatgcgg ttgcaagcgt cagtaaaaac aggccaattg ccaacaccgc aagcacagca 3042901 gccatctgca tgaaacctat atctttatgg atggctccca gcaataggac gactccaaat 3042961 atagcagcgg ccagtaacgc tagcgtatgg accgctgatc gtttgatact cacatgttta 3043021 acccctttcc tgatgtttca ggagccggcg gccgagccta gcagccggca gcttcaacca 3043081 agtaacactt tttcttttta taaattgacg cttcccaagt ctttagccaa ttcttcaagc 3043141 ggcaagcccg gaaaatactt gtcagagggt tccgttcccc gaacagcggg acggccgata 3043201 gagtgataaa tgtatccggc tgcctgcatc tcttcaagtg aaaataaatt tctgccgtca 3043261 atgatgactg gctgttttaa gagggttttc acttttacaa gctccatttc tttcacttcc 3043321 ggccaatccg ttaaaatcag gcatgcatca gtgtcttcca tcgcagcata cacatctgtg 3043381 taatactcga cctgttcgcc aaggatcgct gaagcttcag gaatagcaat cggatcgtat 3043441 gcttttacat gggcgcccag ctgctgcagc attgggataa tatcaagcgc tggagcggat 3043501 ctcacatcgt tcgtattcgg tttgaaggct aatcccagga ctgaaatggt tctccctttg 3043561 acgcttccca taacagtcaa aagtttatct acaatatgaa cacgctgctt ttcgttcgtt 3043621 tcaatgacag cttcgatgag cttgaatgga tagcctgccg attttgcgat ttgaagcagc 3043681 gcggttgtat cctttggaaa acatgaaccg ccgaatccaa taccagcttt aaggaacttt 3043741 ctgccgatac ggctgtcaag accaacacca tcagcaactt ttgaaacgtc tgcgccgact 3043801 cgctcacaaa tgtttgcgat atcgttgata aaggaaatct ttgtcgccag aaatgcattc 3043861 gcggcgtatt taatcatttc tgcactttct aggtttgttt taatgacagg agcatggaat 3043921 ggctgatgaa gttcctcaat gatggcagcg gctttatgac ttgttgaacc aatcacggca 3043981 cgctccatat tcatcgtgtc atgaatcgct gacccttccc gaaggaattc agggttagat 3044041 acaacatcaa atgagtatct cccctttgag gctttttgaa cgatagattg caccagtttc 3044101 cctgttccaa ccgggactgt gcttttattt acgatcactt tgtagccgtt aagatgctca 3044161 ccgattgttt tcgccgccgc tttgacgtac gttaaatcag cttcacctgt tttggacata 3044221 ggcgttccga ctgcaatata aataatatct gaggcccgaa tggcagacgg gatatcgttc 3044281 gtaaaggtca ggcgctgatc cagcacattt ttttcaacta agtctgcaag ccctggttca 3044341 tagattggga ttaccccatt tttcaggctt ctgatttttg attcatcgat atcacagcaa 3044401 acaactttat tgccgatctc cgcaaagcaa gtgcctgata cgagtcctac ataacctgtt 3044461 ccaatgacag ctattttttt cacagcgctc aaccctctcc tgtaaaatga tcttccaatt 3044521 tataatggtc gcagtgtctt acgattaaac ggacgttttc gtgaccgtct gatactgatg 3044581 atgcaaggcc ttggcgtttt ttcctgcgtc aaattgagcc tgcacggttt catacaagtc 3044641 atctgctact tccggcttcc atatttgctc atgttcgtac cgagtgatcg cttccgccaa 3044701 ggcttgagcg gatttcggtt taatcagcag atgttggtgc tttccgaata aagacgacac 3044761 tccgccaaca tccgtacaaa taacaggaac ccttagcgcc agcgcctcaa tcacaacagt 3044821 cggcatcccc tcactgtaag aaggaagtac gaatagatct gccgcaagta aatagtctct 3044881 tacctgatga ttcgggactt ggcctgtgac gatatgcccc ttctgcgtca gcgtcgattt 3044941 tgcgggacca tccccgacaa agactgcctt aggagagtcc tgcagcgatt cgatcgcttc 3045001 agacagttca aaaatgcctt tctctctgac cagccggccg acatagacag ccagacgctg 3045061 atcgagcggg agtccgagtc tttttctgat ttcctctttc gtctcctcat tcccctgaaa 3045121 acggctgagc tgtatgccga ttggcaaaac cgagctgtca aagcccgaaa gctttttggc 3045181 ttcttcctga agcttgtggc tgactgctaa aacaactgac gcagaaccta cggcacgctt 3045241 gaaggcttta aacgcacctt tgctgtaatg cggatagaca ttcacatcac tgccatgcaa 3045301 ggtcaggaca taaggaattt gcgctgactc tgacacgact gccgcagccc cgcccgatgg 3045361 catggcaaaa tgcgcatgga tcagatccgg atataggtcg cgctgtttca ttgtttttaa 3045421 aacggctgat gcgattctcc gatgaggctg cgcccacttc agctggccgg gaactgcccg 3045481 atagaaaggc cggtaaaccg gtatcccctt tctaatctca tactccggtc tgacatcctt 3045541 ttttcgatat gtctttttca gcatgcggac aggtgctgaa tgaaaaggcc gtgggcatat 3045601 cacagtgata tcaagcccga gtttttgcag ctcttgcacc tgtgtctcat gaaacacacc 3045661 ctctccgggt ttcatactgc tcggatatac gcttgtgatc cacaaaatct tcatgacaaa 3045721 cgtccttttc ttagtagttt gcttttcgtt tgagggtacg cttttaccaa aagaaagaga 3045781 tagcacagcg ccccagccgc aactgaaatg gccagccgca tttctgcctg catactgaag 3045841 tgttcggtac tgaggcttac accaaacgcg atgatgccca tcgccgcagt aatcagaaat 3045901 ggcttcataa tcgactggaa ataagctgaa aggttaagct tgatgacata tgccaaaagc 3045961 cagcgcccaa tcaggaaatt aacaacgctg ataatggcat acacccatgc gactgtcagc 3046021 aggcttcccg tctgtacagc tgcaaacagt gataatccgt acagcagcag cacgccggaa 3046081 tcccaataaa acgctaagtc agctcttcct ttagccagca acacagatcc atttggattc 3046141 atgagcactc ttagtattcc gacaatcgca agaacattta ggatcggaac agcagcaagc 3046201 catttttctc cgaaaaccgc tgtgataaag gcgtctgaca cagacacgag cccgattaac 3046261 agcggaaacg aaacaagcgc cagcattttt gtcatattca gaaagccttc tctgatcacg 3046321 ctgttttcat atttgttttt tgcgaaaata gggaatgcca cccgtgtgac aatcggattg 3046381 atcttcaaaa ccggaatggt gacaatctga taagcgaggt tataaatccc caatgcttca 3046441 gcaccaataa accggccgat caaaatcatg tcgatatttg ctcccagcct gttcacaaga 3046501 cgggatgaaa gctgaaaggc tccaaaagaa aagaaatcct tcatgcctct caaatcaaaa 3046561 acaaaagcag gatgccactt ttttcggtat acagcccaat ataaaatccc tttactggac 3046621 tgcagcagga cttgagaaat cacgtacgcc aaaatcgcat ccatcataaa aaccgctatc 3046681 gctaaatatc cgaatgacaa tacatttgaa aaaatctcta ttttgcttaa cgtattaaaa 3046741 tgcagctgct tttgcagcat atactgatat tgctgtccaa ttggcgcgat caaaaacata 3046801 atcgccagaa tccgaaccag aaacaccagc tcttctcttt gataaaatcc cgcaatgaca 3046861 ggactgctca catataaaag aacaaacagc aaaacgcccg tcataatgtt aagccaatac 3046921 aatgttgaca gctggcgctc cgtcgcgtcg tctctctgaa ttaatgctgc gccaaaaccc 3046981 atatcgagca caatctgggc gaaaactgta accgttgtga tcatgccgac aagcccaaat 3047041 tctgttaagg tcatcatatt tccaagcagg gcaaactgaa caatttgtat gattgtaata 3047101 cacatggttg aaatacttgt ccactttgca ccgctcatga tttgttttgt aatacttggc 3047161 atcatattcc ctacttcttt ttaagctcag attgatggtg aataatggaa tcccgtttta 3047221 tcttgcacca tcacccgtcc aaactacttt acaagttttt aacataattt ttaattctaa 3047281 agtgaaagtc agattgcgaa tgtaatataa atcaaatatc agcttttcct tcggcgtcat 3047341 atcgtaaccg ccgttcacct gagcccagac gctgtgtaaa gcctggaatc tcattctgga 3047401 atttttccgt aaatacgggc cgttccggac gagggccaat catactcata tcgcctttca 3047461 gcacattaaa cagctgagga agctcgtcaa ttctcgttct tctgataaaa gctccgatcc 3047521 ttgtcacccg cggatcttgc ttctgtgccc aaaccgcccc agacttctcg gcatctattt 3047581 tcatggaacg aagcttataa agcttaaatg gcttcccgcc tttccctacg cgttcctgcg 3047641 tataaatggc aggccccggc gtctccaaac aaatcaaaat tgaaaatacc gcaatcattg 3047701 gcagcgcaat cgccaatcca atgagcgcaa accaaatatc cattacgcgc tttattgcca 3047761 aataacgagc cgtcttttca gataatgtaa aagaatgtat ttgttgaact gagaattcac 3047821 gactcacatt catgcttttc tctgcactca ctgacacaca cctcacgatt tgtttgggat 3047881 gttatgatga cctatgccag tcagtttagc agacggatgt taattggatg taaatggtat 3047941 gttaagaagt gtgaattacg tgttttttct gataaatgtt gttaatactc ttttactatt 3048001 ttatatacaa gtcctatttg ttttaatcat ttcatataaa aaagagacaa atctgtgatt 3048061 agatttgtct ctttcgatta tctgtaataa gatactgtgc cgtcatgaat agcttgtgca 3048121 gctttatctt tataaaccgc ttgcttcaat ttacttgcat ctgatgcatt agtgataaag 3048181 gcagtttcaa ctaaaacact cggcatttta gaatatttaa taacatagaa agcagctgtt 3048241 tttactcccc ggtctctcgt tccaagatta gccgctaact ttggttgaat ttgttcagcc 3048301 agtctcttgc tatttgcagc ttgatatgtt gtatcgtagt acgtctcact tccatttggt 3048361 gatgagctat cattagcatt tgcatgtata ctgagaaata aatctgcttg tgcagaagct 3048421 gctttattta ctctctcctg taaagaataa aaagtatcat tagatcttga cagtactgga 3048481 agagcacctg aagcatttag ctttgtattg actcttttcg ctatatcaag gttgacttct 3048541 ttctcaagga gtccattgcc gattgctcct gaatcttgat caccgtgacc cggatcaata 3048601 aagattgttt cacctacaac tggattcttt agctgattag caacctttgt gcttacggca 3048661 ggagtgtttc cgataatcat aaagtttgac atgtttttac ttccaataat tttacgggct 3048721 cctgtagata aattttcacc atttgtaaga ataagagatt gcttcttctt agctgccagt 3048781 gtagctcctg caatagagtc agggtagctg aatccattgc ttacatatac ggtgcttgtt 3048841 gataaattaa gtttttgtac gatatttgca gcaagctcat atctgtttga accgctaatt 3048901 cttgtaggag aaggtaactt gttgtatacc gtattgctga tacttccagt gcctcctaca 3048961 acaacggtac tcgaaattcc cttatctttt atcacagacg tagtcgcact atttatagat 3049021 gttttatttg taaaaagaat tggatacccg tttttcgctg cataagggat gacggccgga 3049081 gcgtctgcat ataagaagcc gttcaaaata acagcttttg aagtcgcacc catcgctttt 3049141 gccacccgtg cagccgtatc ataacggttg cttcctgcaa ttcgtttaat acttatcccc 3049201 aagcttttaa tctggttagc agtgttagaa gaaacagcag gtgttccgcc tacaataatt 3049261 acatttttag tctgcatctc tttcaatctt gttttcgttt catatgaaag cttatcagaa 3049321 ttagtgtaaa gcaatggcgc attcttctgg taagcaagag gtgctgctga aatagcatct 3049381 gcataggaac tcccaccaac aattacagct gtacttgctg ttgaatacat ttgctttgat 3049441 atttgtacag cagtgccgta tctattgctt cccccaactc ttttcactga gttatcggcc 3049501 aaagctgttg gcacaaaaag tatgagcccc agaaaacaca ttgttaggac ttttatataa 3049561 gaacgcaatt gatttcctcc ttaaatggcg ttatatccta aaataatcaa taacttgtca 3049621 gagttgtacc tggatagtaa aatttcaaaa ttgaactata tgaatctcca gcttctgctc 3049681 ttgcttttgc tccatattga ctcattccga tcccgtgacc atatccttta ccgctgattg 3049741 tgtactttga agtatctttt tttacagtca cataagtact tttaaataca gtcgctccaa 3049801 tcattgttct taactcactt gttggtacac taatggttgt aattttgctc aagttatagg 3049861 agccagtact gcttttaaca aaatacttca ctttcatcga tgctgttttt gcacgctgcc 3049921 cttgtgtcgt tccactaaag cttaaatcgt caatacttgc aattttgaca gaatcagcgc 3049981 ttgtttcttt atttttcaag atccagttct taactccgga aagtcttgca gaatcagttt 3050041 cagtcgctga agaccaccaa gaagaaggct tcgttaagtc caaagatttc gtatctagct 3050101 gttgttttga caaagtaagc gtccagccta tttgaggatc ctttgtatct ttttttgcaa 3050161 tcaagtaagg tacacttgac gaccacactt cattactagc ttctgtgtaa ccaccattac 3050221 tggaagaata agctgcagtt ataagagatc cattatattt cagaactttc cccttcgttt 3050281 gctctaccgc tttattggta ttcgaattcc aactgtagcc accataaact tgaaaagcgg 3050341 ttgtatcagg tacagtagtt cctgtttttg ttattgagta ggttcttgca gcgacagtct 3050401 gtgctttaag agcctcaagt gaccagctag caggcatttc attcggaatt actcctttta 3050461 agtaatcctc aaatggaata ttctcattta ccggtcggat atatttagta gactcaatag 3050521 agaaattaac cgtgccaaga tactgctttc catcaagact aattctgttt gaagtagaat 3050581 agttttctgg tttaattctt agggagtttc cgtaagtttt gatgttttca aggtttaatt 3050641 ttccgctgtt gatttttaga ttataggtgc caccgtcagc taaataaaat tcatcagcaa 3050701 gtgaattctc aacttcagca gaaattgaac tggtacttcc aataaagtcg tatgcatatg 3050761 tggctttatc tttcgttata cttttagccg cagccggaac gctatcttgt ttaacaaata 3050821 aaatttggct gtttttcttc gaggcaagcg aagcgcctat caatacgtct gcatattttg 3050881 tcccgttcgt cattacgact ttatcagcct tcaactttag ttgcttaatt atatttgccg 3050941 taagttcata tctggttgat ccaggaatcc tttgcacagt tgaagttttt ttaatttggt 3051001 tttctacact atcactgacg ctaaatgaac tgcctataat gatgacttgt tttggcaaat 3051061 cataatccgg aagcttgtct ttctctgtaa gcaaaatagg gtatccgtgt gctgctgcat 3051121 atggagcaat ggctaaagcg tcttgaaata ctcttccggt tacaacgatc gctttatcat 3051181 agctgcccat ttgctttgca atattttctg ataagacata tctatttttt ccgcttatcc 3051241 ttttcacagc gccatatgat ttcagcttgt tttctacgtc ttttgaaatg cttcgcgctc 3051301 ccccaatgat taaaatatta tcagggttaa acttagcaat ttgtctttca gtagtttttg 3051361 ttaacgtgtc aggctgagta aataaaactg gtgcgttcag ttttttcgcc aatggaataa 3051421 caggcaatgc atcaataaaa atatctcggt tcaccaatat cactgtatta ggatttttcc 3051481 actggctgtt ggatgcaaga gtcgcagttt cgtatcgtga agcgcctgca aaacgatccg 3051541 taacagcaac attatctcca gttactttat aaaatcctgt tggcgataga ctgatgctag 3051601 atttatttcc aatataattt aacaatttaa ctgagatgtt tgagtctgct gcaaaagaaa 3051661 ctgatggaat caataataag attgcagcaa gtgaacacac tatcaattgt ttgcaagatt 3051721 tcaaaatttc aggttcctcc ctatatctta gttggcacgt tcaatatctt ttaacagaag 3051781 ctgaccctca tcattttttt catatgtaat cgtgacctta tctccactgt taaacttatc 3051841 aagatcactt gtcgattctt cagtgatatc aagactaacc ggctcattat ctactgttac 3051901 ttctattgta tgagtatcag ctaaccctac ataagtacct tcttttgttt caatgttact 3051961 gtctggcgat acatcttcac cttgactctt ttgactatta accccgcaac ccgaaagaag 3052021 caatataaag aacagtaaag caataaattt tttcattttt ttcacctcat tatattttat 3052081 cgtcaaccta ttttatattt taaagaaaaa ttaagaaaca atgaaacttt tttttataaa 3052141 aaacgactat tttaggattt cattcttgta ttaaatagag ttgtatttat tggaaattta 3052201 actcataatg aaagtaattt aacagacgag gtgcaaagga tgagaaacga acgcagaaaa 3052261 aagaaaaaaa ctttattact gacaatttta acgataatcg gacttcttgt actcggaact 3052321 ggcggctatg catactactt atggcataaa gcagcttcaa ccgtggcaag tattcatgaa 3052381 agcattgata aatctaaaaa gagggataaa gaggtcagta tcaataaaaa agatcctttt 3052441 tccgtcttaa tcatgggtgt ggatgaacgc gacggcgata agggccgtgc cgatacgctc 3052501 atttatatga ccgttaaccc aaaaacgaat acaaccgaca tggtcagcat tccgcgtgac 3052561 acgtatacaa aaattatcgg aaaaggcaca atggataaaa tcaaccattc atacgctttc 3052621 ggcggcacac agatgacggt agacactgtt gagaacttcc tcgatgttcc ggttgattat 3052681 tttgtgaaag tgaacatgga aagctttaga gacgttgttg atacacttgg cggcattaca 3052741 gttaacagca cattcgcgtt cagttatgac ggttattcgt tcggcaaagg agaaatcacg 3052801 ctgaacggaa aagaagcgct cgcttatacc cggatgagaa aagaagatcc gagaggcgac 3052861 ttcggacgcc aggaccgcca gcgccaagtc atccaaggta ttattaataa aggcgctaat 3052921 atttcttcca tcacgaaatt cggagatatg tttaaagttg ttgaaaataa tgtgaaaacg 3052981 aacttgacct tcgataacat gtgggatatc cagtccgatt acaaaggtgc gcggaaacat 3053041 attaaacagc acgaactaaa aggtacaggc acgaaaatca atggaattta ctactaccaa 3053101 gctgatgaaa gcgccctttc cgatattaca aaagagctga aggaaagcct cgaaaagtaa 3053161 aacaaaaaga agcttcgcac aatgtgcaaa gcttcttttt tatttgcctg taaatgaatc 3053221 cggttgttct tttcgatacc cgtaatgaaa cagcaattct tccacaatcc ggcgggaagc 3053281 ctctccatct ccatacggat tagaagcctg ggacattttc ttgtactcat caggatcagt 3053341 taacagctgt tttgcaagct gataaatgtt ttcctcatcc gtacctgcaa gtttcagcgt 3053401 tcccgcttcc actccttcag gccgttccgt cgtatcacgc agaacaagaa ccggtttccc 3053461 gagagatggg gcttcctcct gcacgccgcc cgaatcggtc aatataaaat gcgatttcgc 3053521 tgcaaagtta tggaaatcga tcacctctaa aggttcaatc agatgcactc tgtcagaatc 3053581 accaaaatgc ttatgagccg cttcccggac aacaggattc aggtgcacag ggtaaacgac 3053641 ttgtacatct tcaaattccc ctacaattct gcggatggcc ttaaacatgt tttccattgg 3053701 ctcacccaaa ttttcccggc ggtgagcggt caagagaatc attttatcct cacccacctg 3053761 atcgagaaca ggatgtgagt aaccatccct aaccgttgtg ttgagtgcgt caatcgctgt 3053821 attgcccgtt acaaaaatag agtcggcctt tttgttttct tttaataaat tgtctttcgc 3053881 ctggcctgtc ggagcaaaat gcaaatcagc aatcgcccct gtcatctgtc gattgagctc 3053941 ttccggaaac ggggaatact tattccctgt acggagcccc gcctccacat gaccgacagc 3054001 aatttgatgg taaaaagcgg ctaggcttcc ggcaaacgtc gtcgtcgtat caccatggac 3054061 aagcacaata tcgggtttga tatctttaaa caactcatcc aatcttacaa gtgcgttaga 3054121 cgtaatctct gccagtgtct gccgctcctt cataatgttc aaatcgaagt caggcttgat 3054181 gtgaaacgca tctaacacct gatcgagcat ctgtctgtgc tgtgcagtta ccgttacata 3054241 ggaatctatt tcaggatatt ttttcaattc aagcacaagc ggtgccatct tgatcgcttc 3054301 aggcctggtc ccgaaaacgg tcatcacttt tagttttttc atatttgtca cctggttttc 3054361 tgctatagta aataaattca tactacatat tctacatgaa aatgcatcat tttaaatcat 3054421 ttcattcttg attcaaataa aatgatataa gttttaatat taaggataaa gcttgtttaa 3054481 aaatggttta tccgatatca taaaaatgtg taaaaacata ttgaaaaggg taaatagaga 3054541 atagtttaac cataaatttt ttcgatcata aggaaggtgc cttttaaatg aaaaaagtac 3054601 gtaaagccat aattccagca gcaggcttag gaacacgttt tcttccggct acgaaagcaa 3054661 tgccgaaaga aatgcttcct atcgttgata aacctaccat tcaatacata attgaagaag 3054721 ctgttgaagc cggtattgaa gatattatta tcgtaacagg aaaaagcaag cgtgcgattg 3054781 aggatcattt tgattactct cctgagcttg aaagaaacct agaagaaaaa ggaaaaactg 3054841 agctgcttga aaaagtgaaa aaggcttcta acctggctga cattcactat atccgccaaa 3054901 aagaacctaa aggtctcgga catgctgtct ggtgcgcacg caactttatc ggcgatgagc 3054961 cgtttgcggt actgcttggt gacgatattg ttcaggctga aactccaggg ttgcgccaat 3055021 taatggatga atatgaaaaa acactttctt ctattatcgg tgttcagcag gtgcccgaag 3055081 aagaaacaca ccgctacggc attattgacc cgctgacaag tgaaggccgc cgttatcagg 3055141 tgaaaaactt cgttgaaaaa ccgcctaaag gcacagcacc ttctaatctt gccatcttag 3055201 gccgttacgt attcacgcct gagatcttca tgtatttaga agagcagcag gttggcgccg 3055261 gcggagaaat tcagctcaca gacgccattc aaaagctgaa tgaaattcaa agagtgtttg 3055321 cttacgattt tgaaggcaag cgttatgatg ttggtgaaaa gctcggcttt atcacaacaa 3055381 ctcttgaatt tgcgatgcag gataaagagc ttcgcgatca gctcgttcca tttatggaag 3055441 gtttactaaa caaagaagaa atctaaacaa aaaggctatt ggacattcat ccaatagcct 3055501 ttttttattt caacatcaaa gtcaatgtat gctcttcatt atcaactgcg aagacctgat 3055561 caacggcctg ccgcaaaaat taataatccc agacaaacac actgattgta gagttaaaca 3055621 aactaaatga aaacataaat acaaacatgc agattaaata gtaaatatct tgtattcaat 3055681 gcaagctaag taaacaccac ttgctaaaag aacaatgact aaacaaccag cattacaaaa 3055741 taattaaata aatttgaagc aattacaaca gaaggcagtg aactgtcgga aagttcattt 3055801 tggctaccat attaatccct ttaactacgc tgttggattt atcaagaatt gtcgggctaa 3055861 tagaaaacca cggaatcaaa ccagccagca ttcaaacgat aaaaggcact tctccgatac 3055921 ctgttatgac cagcttactg ttgcgcatcc caaatacaaa ccagtacgcc atcattagaa 3055981 taaggggatt taaaacctgc cataatacac caaaataatt gattttttgg atctttcggt 3056041 taaagaaatt taaaagtacc agtgaatatt gtaacaaatg ttgagttttt ttcactttta 3056101 aaaagtaaag agaagtctcg cagaacttct cccaacattt gaagtgtcaa tataaaacaa 3056161 accaacctca tttagcaact ttattattat ctaattccaa aatagcatta taaatacgat 3056221 tcctattatt tttatcagta tatgcaaaaa agttatctac tctttttcta tacttatctt 3056281 ccatacgact attgtttttc atataataga taactttatc cactaagcta ttatgatttt 3056341 ctaatacatc accaaacccc atttttttat aatcataata atcaagttta aaatggtatg 3056401 acttttcgta ttgataataa ataacaggtt ttttctcata tgcaaaatca aacgcaacag 3056461 atgaaaaatc agtaatcatt atattagaag aattaaatag catttgatag ctgctgttat 3056521 agtcggcaaa ctccacataa tcatgctttt caaagtctac aatctgttgc tgaatatctg 3056581 ggtgaggaaa aaaagttatt ttataattat ttttcttagc aaattcgatt agccgttcat 3056641 cattaatcaa agcattatac ctagaaaaat attcactatc tttaaatttc gggttgtacg 3056701 gtcttactcc ttttgcctga tctttcggta atacaatatc ttttctccaa gtcggcatta 3056761 ttagaagttg cttttctccc tcactcttct taagattatc gtatctcgga aatccaccca 3056821 acaaaatatt ctctttttta tagttgtaat tccctttcac aatagaccga tattcaggtt 3056881 tggcagaagt gactaataat ttgatattct tgttgtattt gtttaaccat tcagaatgat 3056941 ctgccattgt tattccgtgc tgtaaaaaga taaactcaaa gttaaataaa tctctaaaat 3057001 aaatctccat attaaaaaat ggatttacaa cccatatatc tgcatgtgtc gatattactt 3057061 tggaagagga taaggttaaa attttatgtc taaaagatct gtatggtatg acctttccat 3057121 attttttgat tctgtcgtaa tccttgctat ctttttttat tataaagtat ttttttaccc 3057181 catcattctt gttgattgca tatttaaaga ggtgctcggc attatcatca gctttgtctt 3057241 gtctgtctat gaataaccat actggttttc tattaaaaat agtgaaaaca tggtgtacca 3057301 ttcttgccat cagtgccttc ttaatcgctg attttcgttt ttttgatttt tcccctgatt 3057361 tatgtaggga ttttaagaaa cgaaactctt ttataaatct atttttaaaa ttgttttttt 3057421 tgaacattaa ttttttataa ttataataaa aaatataatc ttttttagcc acataagtat 3057481 tatataaatc gtttgacaaa cctgaatact tgaaaaaacg aagttttgtc aacttccttt 3057541 ttttaccctt agttataaaa aactcaatat gatgattatc tgctagatga cctttgggaa 3057601 tatctattga aaaaccggga tattttttta ttacttctcc taaacttata taatcattat 3057661 gctgtctttt tatattcttt gcttttattt ttgtttcgcc aattttagca taaaacttaa 3057721 aacctttaga attaaacagc gagctccaaa agccttctat gtgaatggaa tcctcatttt 3057781 cttctaaaat ttcaatagtt aaagtttgat ccgataattt cgaaacaatt ttaccttctc 3057841 tgtataaata ataatcctgt tcagtttctc tttcatatac atacctacta taattttcac 3057901 cgtgctttat ttttaaagca tgatataaat agaaatggct gacacttttt gtttcaatga 3057961 tgacatcgtc gtcaatatac gacaatactt ctcgaatcaa tgttaaaaat tcactgtatt 3058021 cattttcgtc taaaggtgtt tcactgatat ccttaatcaa taatttccac ttcaaatcat 3058081 gcataaccat atattgaaga aataaaggta ttttctgttc atgatttttt ataatatcga 3058141 ttaaattctt tgagaaagtg ataagtgaat ggttaaacca attcttattt gctttagcag 3058201 tctgcatggc agatgatcca tcttctctaa ctctataatg gtattttgcc tctttaacca 3058261 gaccatactt tttcttttgc gatatgatta aattaactag tttggcatct tcacctattt 3058321 tacaattttc atcaaacctg atatttttca aggcatcttt ttttataaat gtagaacaac 3058381 aatgagttaa tatatgatgc ggttcttttt ctacatccaa aattcttgta gaagaaaact 3058441 tattatttag attatgttct ccagttcttc cttctgcaaa aaaaataggg attgctacaa 3058501 tatcaatttc attcttatgt tcgtcaaaga agtttaaaac attttcgaat gttccttctg 3058561 aaactaaatc atccggatcc aaaaattgaa tatatctacc ttcagcatac tttaaaccat 3058621 aatttcgagc actgctcact ccgccattct gtttctttgc atagacaatg ttattgggat 3058681 atttctgagc atattcttta caaatgattt cacttttatc ggggctatca tcattcacca 3058741 gtattaactg aatattctca aaaccaatag tttggttaat gatactttct atagcttcag 3058801 tgagatacaa ctcaacatta taaatcggca ttataacact gaaatcatag ttaaaacttt 3058861 tttcgttcat aaaagattac tcctaacata atgtttatat gaataagaat tcgggtaaat 3058921 aaaattaaga aacaagagag tactaatttt tgcaaaacaa ttttaattta gtaaaatgta 3058981 tgaaaagcat tccttacctt tttttaaaaa cccttgtaag caaactttta aaaatgttca 3059041 catggttaag ttctaaagaa tcatttggtg tttttagtac aaagtcaaat gcaaaggccc 3059101 aaatcggtat ttcgacaaca aaaccagcat atctaaaatc tcttaattta tatccccata 3059161 cttcaattgt ttttttcagt tcttttcgtt tgcatttttt taatctttta aaatatttta 3059221 tatatattct gtcattttct ttcatctcat aatactggtt aataaagtgc cctgttaatt 3059281 caagtctaag cccttttatt tttgccgaag taacagtaca tgaactatgc agtactcttt 3059341 ctttttttat attttcaaga gcttctgtat tttcttttaa taagtgaaac ataaattctt 3059401 tatagtacat cggcatatct tgttctttta taaattgcgg gtcaataaat tttaaaactt 3059461 taataaaatc atcaacaaaa actctttgtt cttgttgatc taaaacagac ttataaacat 3059521 ctctatagtt cggatataaa aacagtttta tatgatatac aattaaaaat tgcaaataag 3059581 gcaaaactat atcatatttg ttgaatgaat ccatcaacaa agtcatgtaa cattcattca 3059641 acaaatatgt gtaccttttt ttgttaaacc atgaacgatc aactaaagaa tcctgttctt 3059701 tccgttttct ataaaaatac tttccttctg caactgctcc gtatcttttt tctttcagta 3059761 ataactggtt aaaaaagata gcgtcttccc aaaactttat agattcatca aaaaggacgg 3059821 tactagttag tgtatgtctt ctgtaaaaag tgccgccaat ataaaaatga atagctttat 3059881 aatcgttgag aatatttata actcttgttc ctttttcaaa tctattattt aatttatgtc 3059941 ccccttcttt ttcacctgtg taataaacag gtaataccgc aatatttaca tgttcggaat 3060001 cacaaaaaaa atcataaaca ctttgcagcg cattttgaga gaatgcatcg tcagaatcaa 3060061 gaaaaccaat aaatttagat ctttcgctta catttgataa tccacaattt cttgcagcag 3060121 aaggtccaga gttttcaatt ttcatgattt taatattatt aggatataga tttttaaagg 3060181 attcacaaat ttgaggactg ctgtcaacac taccatcatc tattaatatc agttctatat 3060241 tttccttaaa tccaattgac tggttaagga cactctctat tgaatatctt aaataatttt 3060301 cagaattata tattggtata attatagaaa acatgtttgt acctctttat ttagaagtta 3060361 aaggatcgtt tcaattactc ttttagaagc cttgcctctt ctaaattaca aaatttatta 3060421 taaaaatcct catagttatg atctatataa ggattatgta acaactcttt taccgtatct 3060481 ataagttctt cacttgtttg aagcaagttt cctggcgttt tttgctgaaa attaaagtaa 3060541 aaacctctga tacagtctct ataagccggg agatcataca caaaaaatac aaggtttttt 3060601 taaaaattca tattatcaaa aaagacagaa gaataatcca taatcaataa atcactaatt 3060661 aaatataaat ctcgaatatc tttatttaaa gaaacatcgt tcacaaaata tttatatttc 3060721 cctaattaaa ttgttctgaa actggataat accattctta caagaataac catagagtct 3060781 ccaaggttcc ctcttcattt cctctaatca aattaaagtt aaatttatac tggccagctt 3060841 tcttaaaatt cattatcccg caaagttggt gcatataaaa ttatttttct ttaattcctt 3060901 atttgataat gtagaattgg taggggattg tagctaaact gtttccagaa tagctttcaa 3060961 ataaaattaa tttattgttt cttggcagaa ggacaaaaat tttaaacaaa actgaataaa 3061021 ctctaactag taaacttctg caattggtta taataaaaat ttcatcagtg aactccttaa 3061081 agagtgaaga ttaatattta cgcaaacaag aaaaaaagaa gcaactgaat ttacttcaag 3061141 cctcttttag ttagtgcttc tataaactag ccatatcttt tctgatttgg gtagttgaaa 3061201 tgcctgctat tcttgtaagg taaatggcct catagtattc ctttgtagac aatcgtacga 3061261 ttaagtaatc ccaggttctt ttgctctttc cagtagcttc atatgtccat agtgaaataa 3061321 atcaaacatt ccgtacgtat cactttcttc attagataac atcaccttcc aaccttttcc 3061381 aacttagaaa aaacaaaaat ccttaactga ttgtttatca tttcgacata ttttttacgt 3061441 tccattaata ataaacaata atagcatatg ttcctataaa agttaaggct ctttaaaaat 3061501 gtaaatcatc agcacttttt gacaatatcg ttgcattgat gtgtattttt tacagatctg 3061561 atatcttatc tatactcatt acaacaagtt ttctattccg gaagagtcaa ttctttttgt 3061621 cgcgttttca agtgtaatga ttttctttct gctgcgtcat ttattttgta cgccctcctc 3061681 atattacttc atcgtcaaaa cgtgaaggaa ttgtaatacg tagttcctaa aaattttcgt 3061741 ggtaaaattt agtgaagtct ttatcaggct aagggacttt atctaaacta cgaattacat 3061801 atggagatat atagatgaaa aggagggttg atatgatata aacgaaaatc aattagataa 3061861 aggaaaaact gaacacttct gaaaaaagtg ataagtttct ttcactatat cctccaaaaa 3061921 gaacctaaag gtcttggaca tgctgtctgg ttcgcgccta actttatcgg cgatgagccg 3061981 tttgcgtttc tgcttggaga cgatattgtt caggctgaca caccagggtt gcgccaatta 3062041 acggatgaat atgaaagaac actttcttct attatcggtg ttcagcaagt gcctgaagat 3062101 gaaacacact gttatggcat catcgccccg ctgacaagtg aaggccgccg ttatcaggtg 3062161 aaaaacttca ttgaaaaacc gcctaaagac acagcacctt ctaatcttgc catcttaggc 3062221 cgttacgtat tcacgcctga gattttcatg tatttagagg agcagcaggt tggcgccggc 3062281 ggagaaattc agcttacaga cgccattcaa aaactgaatg aaattcaaag agtgtttgct 3062341 tacgattttg aaggcaagcg ttatgatgtt ggtgaaaagc tcggcttcat cacaacaact 3062401 cttgaatttg cgatgcagga taaagagctt cgcgatcagc tcgttccatt tatggaaggt 3062461 ttactaaaca aagaagaaat ctaaacaaaa aggctattgg acattcatcc aatagccttt 3062521 ttttatttca acatcaaagt cagtgtatgc tcttcattat caactgcaaa aacctgatca 3062581 tctgtattca caagaaaacg cttcttgctg ctgtcataca atacatcgct atcacttaag 3062641 gatagtgacg ccgggttgat aggagaaatg ttatgaaaaa taagctctgt tgctttatca 3062701 ttctccagta cataactgat tttttcataa tcaaaattca gcgtttttct gccgtcagcc 3062761 ttatttcctt cagtataacc attcaatttc gattgaatgc tggtgctgct gtctcctagg 3062821 aatttcagaa agtattcata ggaagatgct gcgttttgcg agacataaga cgtaaatgca 3062881 gtggcatgca attcagcgtg tttcatgtta gttgcaacag cgctctgttt cacataataa 3062941 gagtgcccgt caaactttat tttcgctgct tgtttgcctt ttgcagctac cgttactttt 3063001 gtaccgaatg gcagtgtaac gtcagccttc tgtttcaaac cctgatcctt ataagcagcc 3063061 gctttttcat ttgctataaa cccttgctta ttgattgcag ttaagcgttc ctctgacttg 3063121 ccctttgcat cgccatgatg gttcttcact tcattttgcg gaatagcgcc aaacgaagca 3063181 attgtacgaa gcggggcatt aaagaacatc gttcccgcca tgaagacagt cagaatagac 3063241 aaaatagcaa tttgaatggc attggccagt gatttcggct ttttcttctt tttgcggaaa 3063301 cgggcaaacg cttcaggatc ttctttcttc ctctcttctg tctgctcttt tttatatgtc 3063361 tctttttctt ttttcgatag cttattaaac cagtcaataa acgctttgta ctctttcaca 3063421 accgtttttg tttcatcaaa catacgaagc tcgccatagt gcatccaagc aacacggtca 3063481 cacatctttt caatctgacc gattgagtgg ctgacaaaga aaatcgtttt tccttgcttt 3063541 ttaaactcat ttattctgtc tacacacttc tgataaaacg tttggtcccc cacagaaaga 3063601 gcttcgtcaa taattaaaat gtcaggatca atatgcacgg agatcgcgaa accgagacgc 3063661 gacttcatcc cgctggaata gtttttaacc ggctgattaa taaaatcgcc aatctcggca 3063721 aattcaacga tgctgtcata catatcatca atttctttat tggttaaccc catcatcaaa 3063781 cacttgagcc ggacattgtc ccggcccgtt aattggttat tcaaaccggc agcaatcgca 3063841 atcagcgacg gctggccgtt catttcaatt tcaccgctgg tcggcggaat aattttagcc 3063901 agcaggttag acatggtcga ttttcctgac ccgtttattc ctacaaagcc gattgtctcc 3063961 ccttcataca cgtcaaagga gacattccgc acagcaaaaa aaccattatc cttagccgga 3064021 aaaaacaatc ctttaatctt gtccgattgt tttttataca aatgatactg ctttgaaaca 3064081 tttcgaaacg aaacttttag tttcatcgta aaatctcctt acgtattaaa gaaagtcaac 3064141 aaacttgtct ctgaatttca tatgcaggat agaacctact aacaataaaa ggaatgtgaa 3064201 caaccaaaag tacagcgtgt acttcatgtc atggaaaaac catgctccat ctaagaagct 3064261 gttccggaat ccttcaataa tatagaatag tggattcaac ttcagaacag gcactaattc 3064321 ggggtggctt tgaccgagtt tcgcattaac atcccaaaaa attggcaaca agaaaaacaa 3064381 aagtcttgtt acggcctgca gcaaaaattg ataatctcta atcagcacac tgatcgttga 3064441 gttaaacaaa ctaaacgaaa acataaaagc aatcatacag atgaagtaat aaatatattg 3064501 taaccaatgc acactcggga acacaccatt aactaggagt acaatgatat aaatcaccat 3064561 catgatcata taactaaata agttagatgc aattgccacg gacggtagag aactaatcgg 3064621 gaagttcatt ttagccacca tattaatgcg cttaaataca ctatttgatc catcaagtat 3064681 agttggactg atgaaaaacc atgggattaa tcctgccagc atccaaataa taaaaggcac 3064741 ttcgcccgct ccggttgtca caggaccgcc ctttctaatc cccataccaa atacgaacca 3064801 gtaggccagc atttggataa gcggatttaa gaactgccat aagacaccta aataattcat 3064861 ttgatattta gacttggttt cataagccgc caatcttaaa attaaaggaa atgacgttat 3064921 ttgctctctg agtatacgca acaaatcatt cattttttat cttccttaga cttaattgtt 3064981 tttgggaatc tttctgttta aaatttgaaa gcaccgctga ttattgtaac agatcctgca 3065041 ttttttttca cttctcaaca agtatctaaa aagctgccga aaaatcgaca gctatacatt 3065101 ttataaaata acctaaatta ttcagcttta aatacagtat taacaacctt ttcagatgaa 3065161 cgtcctgact ctaaatagca aaacttatca tagaaaggac caaaagaaac cggaagctta 3065221 taatcaggcg atgagatctg cttgatagcc tcaatcgttt cttcagtagt ttttaccaaa 3065281 ggaccaggag cttctttttc aaaatcaaag tagaaaccac gcaacttgtc ccggtaggtt 3065341 tcgatgtcag ggacaaagaa tagcattggc cgttttaaat ttgcaaaatc aaagaatact 3065401 gaagaataat cagtaatcag caaatcagaa accatataca attctcgaat atcctcataa 3065461 gcagaaaaat catatgcaaa tccttcaaaa ggacctaaat caaaattctc agctaccaga 3065521 taatgcattc ttaagattac aatatattca tttccaagtt cttgtctaag ttgatgcaaa 3065581 tctaaatcga gatcgaactt ataacgccct tttgcataga actgatcatc tctccatgta 3065641 ggggcatata aaataacctt tttatcacga ggaatattta acctactctt tatcaatgat 3065701 attgtttcct cattattatc attatgaaga aaatcatttc taggatatcc agattcaatc 3065761 attgtcttgt taaactgaaa cgcccgtgta aagatctcag ttgaataacc atttggggaa 3065821 atcaagtaat cccaattaga agcttccttg ataaaattcc ttttatattt tttggtgttt 3065881 gtaccaggca tatggacttc ttccatatcc attgcaagtc tttttaaagg tgtgccatgc 3065941 catgtttgta aatatgttgt atgactaggt ttcggaatcc ataatggaag ccggctgtta 3066001 acaacccaat actcagctct tgccatagcg aagagccatt ttaatgagag gcgattaatg 3066061 taaggaattc ccttttcatc aaaaggcgct gaatattgtt tatttacact ccaatacatt 3066121 ttatactcag ggtggttttc ccgcatatat tcgtaaatcg ctctcggatt acaactgtat 3066181 tgtttcccat taaaactttc aaaaatgact gttttccttt taactggcat tctgctagcc 3066241 atcatgaata gagatttgta tgttttagtg attaacttgt ttctcatttt tgtgatcttt 3066301 tttatttttg atactaatct cttcttcttt cctttaataa agtatttcat ccttgttttc 3066361 aggctatagt cgtttactct gatacctaga gtctgctttt tctttttctt aaagacttca 3066421 taacgaactg gtgcgttgtt tgttttaata atacttacta atccttttaa tttgtttttt 3066481 cgatctccta aaacaagagc agtgctgttg aactgaatat ccgttccttc atcgtcattg 3066541 catatatact ccataaaaag acgataaaca taacgttttt catttgagaa aggaatttct 3066601 ttcaaaggca ctttcacttc aaaatcatac agttccggaa caaaaccatc tgctctcatg 3066661 ttttccaggc catgtgtttt tctttctagc ttgattggaa atttttcctc aataggtgtt 3066721 tctccaccct tttttaaaat aaggttcaag ttttttatcc gatattgatt ttcggaactc 3066781 aggtaccccg cataacctgt tatgcttatt tcttcagagc taatctcgat ttgatcaaat 3066841 ctgatgattt tggcctctct tttcacctta atagaaaagt tgcctttatc agttgtataa 3066901 ggtaaaatca aaagttctgt ggtttgatcg acatgaaagg cgcgctcaat tgaatttact 3066961 tcagcagaaa gacgcttcaa gagtggttcc tgctccgcat cttcatattt ttttcgaaat 3067021 tcgacataaa aatcatatgt ttgtcccatt tcaacaggca taggcaaaac atgagcattt 3067081 atctcagttt tatactctaa tgagccagtg ttttgaagcg gaaattcaga ttccgttcct 3067141 gaacgtctct ctttcagctt taaaaataac tggtaatcct ctaaaaattg gtgttctgaa 3067201 tcaattgaga ttaacaattc aagacttcct aaattgtttt tcaagctttt caaaatacat 3067261 ttaatcacag tgttttcaat cattactttt ttctgctcct ctgtataaaa gctctttcct 3067321 ttttgcttcc ttttattagt gtcaactact aaggacatta actctctttt atttccgtga 3067381 ccctccaaga gaaattgcct ttaactgttg tatagggctc tactctatag ccattattag 3067441 tatctatact gtttcctgac aattttgttt cttcactcga aagtcttcgc attgttttaa 3067501 tatggccatt tgcattgaaa acaatataaa aatcaataac ttgggtttta ttagcagcta 3067561 tcttttcaat atttacatct ttttcgagat caattacaaa cagttgatca ttttgtaagt 3067621 ttgttgaaat aatttcagcc ttattctttc tgtccaagcc cactaaacgt atttttttaa 3067681 tatcattatg atcaaaattc tcaatgtcaa tttctatttt agttttatca aaatcctcag 3067741 tataggaact aatagaagga tctttttttc caaccttttt agagaacttc tctctttcta 3067801 ttcgcacctc aatcatctga ttaagagcaa aagcccaatt ttcaatatag ttgggtcttg 3067861 aatatttttc agccatttta aaagcttgtt ctgaaaattt ttgatgagta ctttcatctt 3067921 tcatcaaaga gataatagct tgacccaatt tctctatatt atactgttca atgacatatc 3067981 catttgctcc gtcagtaact aagctccttg ctccgtaatc ataatcgtat gttacaactg 3068041 gacatccatt gctcagtgcc tccatatttg atagaccgaa cccttcaaaa tgagaggttg 3068101 aaatggttag ccaagctttt tgaaactctg agtcagggtt atccgtatag cctttcaaaa 3068161 agacattgtt ctgcagtttg gtatcttcaa tttctttttt tattttttcg aaatcttcac 3068221 ccgatccgaa tatatcaagt tttgcttcag gaatttcttt cacgactaaa ctaaatgctt 3068281 ttactgcatg tatcagattt ttcatagatg caagtcttga aataatgaca gctttgtatt 3068341 tttcactcgg cacattcaat acagcgggat caagaggctt atcaattgta tgcggagtaa 3068401 agaaaaacgt ctcttgttcc cctgaaatca atttaaaatc ttctagctgc tcctcagtta 3068461 taaaaaagac agcatccaaa ttatacatct gactaaatac ttctttatag cgacccttaa 3068521 tttgatattt attgctgccg taatgcttgt tatgaataat tgctccataa taggaagaag 3068581 gtgatttttt cactttaaag acatgtttgt cttgcggtct gctgtccact aaaaacaact 3068641 taggtttatc attttgtttt tgcagatatt ctatccaata ttgacgcagt tccgattcat 3068701 cttttacttt tatctcaccc tcaagggagt accaaataat atgagataat tgaacatctt 3068761 tttcttcatt gttccataca tagagtttgt ctaaatatac ttgattttgg tcattaatat 3068821 attcctgcag atacatcttg tttagctgca catcataatg agtaacgaga actaagtttc 3068881 cgttcttcgt atattcctct ctctttatga gctggttttt atcattccaa tagtcgacgt 3068941 accggatagt ttctccatct ccgtagtaaa ctacagacat ttcattgttc ttcttaccaa 3069001 acaatctcaa cagagttttt gcaaatttcc ccattccaac ttgctttttt atctggtcaa 3069061 ggcctatcct ttcttcgtat gatcttttcc catttgttct aacacttaaa aaatcatcga 3069121 atagattaat aacacttgtg aattttttat caatcttacc gttgctgtac aattcatcaa 3069181 tttttgaaga caactctaaa tcaaaacgaa acgttaagaa aaaggtgttt tggttacact 3069241 cttctccaaa taattttgaa cgcaataata atgatttcgt cagaccgcca taattacttg 3069301 gcagtccacc agagataaaa taataatcca tgtcaggaat ttgttttata ttagattcac 3069361 tcaccgcatg taaagacaat tttttactcc ctttcggcat ctagaatata tgatcattga 3069421 aatttatatc tacccggata ctttagtcac aaaaatcaat gtaagcatca aaaagtactt 3069481 cttatttcaa taagaagtac tttaattaga tattgaacca atgatatcag gatcctaaat 3069541 tataaaccag caatttcctc tttgatcttt gttgtagaga tgccttctgt tcttgggagg 3069601 taaacaacct cacactgatc tttgagaaag tcaaatttac cttcccagtc atcccccata 3069661 acaaaaacat caatattatg atcaataata tcttgctttt tttgctccca attcttttca 3069721 ggaattactt cgtccacata tcgaatggtt tctaaaatta atttacggtg ctcatagctg 3069781 tgataagctt ttttttgctt ttgtaaattg aattcatccg ttgaaatagc aacaactaaa 3069841 taatcaccaa gctgctttgc acgctcaagc aatttaatgt gaccccaatg cagtaaatca 3069901 aaagttccat atgtgataac ttttttcatt taaagaaacg ctccttccta atgttaaaca 3069961 ctattaaaaa cactactgac gttagcgatt aaattctaaa aacctgtttg tattccttat 3070021 atcgacatat ttctcgtatg tcttcactga tcattaatta tagcataccg cctaaaaaag 3070081 gttaagtact catgaggaga aaaacattcc aaaatatgta attacactca gactccattg 3070141 gcaccaaggt ctgttgttca ttcgttcatt caattgtaaa attggaaaca tatttaaatt 3070201 taatgtaaag ataatgttaa tcctttgttg aagatttatg ttaaaatata aggtagcttg 3070261 attttgcttt tagaaactct cggtttttaa ctatataaat agaatcttaa aggaaggagg 3070321 agccagacat gcaaacagag actattcaca atattcctta tgttaacagt aacttaacat 3070381 catttatcga ttacctagag aaacattata ttgatcaaaa gattggtgct gtcatttcca 3070441 cagtcaaccc tgaaattgca tttgcagcta ttaaagatcg ggactacttt gatgtactat 3070501 cttcttcaaa cttcattttg cctgatggga tcggtgtagt catgatgtca cgtttgacta 3070561 acaacaggct tcagtcccga atcgcaggtt acgatgtttt taaagaactt ctgggcgttg 3070621 ctaacaaaaa gaaaaaacgc atatttctgt acggtgcgaa gaaagatgtt ataaaaggtg 3070681 ttgtatccaa aatttcttct gaatacccaa acattaaaat cgcaggttat tcagacggtt 3070741 atgttcaaga tcgcacccta gtggcaaaac aaattgcaag agcaaatcct gacatggtat 3070801 tcgtagcttt agggtatcct catcaagaga aattcattca taactacaga cacttgttcc 3070861 ctaaagccgt atctataggt ctaggaggaa gctttgatgt atttagcggt aatgtcaaac 3070921 gggccccttc ctggatgata cgtttaaatt tagaatggtt ctaccggtta atcttgaatc 3070981 catggcgatg gaaaagaatg cttagcatcc caaaatatgc tttaacggtt ttaaaagaag 3071041 aaaaaaacaa aaaaactttc tatccaaagc ctgaaaaaga tcatacaaaa cagatttaaa 3071101 aacaaaactt tcaaataaat ggatgataaa aatgaaaata agatcactac tggcgaattg 3071161 ctatttgtat tttttatcag caatcgcctt ttttctgcaa tgggtgaaac ctgaaagcaa 3071221 agtgaccctc ctgatctcat tcgaagcaaa cgcaaaagcg attcttgagg aatatgaaca 3071281 aggacaatac tcttataaac ttaacatcct gtatacccag caggcctctg ctattgccga 3071341 gagcttcccg aatgtagatg catatttatt acaagaaaaa aaccctatcc atctcattaa 3071401 agctgtatac ctaatgttta acagtaaagt gatcataaca gataattact ttctattaac 3071461 aagtgtgtta aataagcgga agcaaacgaa atgtatccaa gtatggcacg caaatggctc 3071521 actcaaaaaa tttggtttgg aagacattac aaacatgcaa cggacgaaaa ctgatattaa 3071581 aaggttccaa aaagtataca gttcgtatga ttatttaact gttggctcag aagagatggc 3071641 aaatatcttc aagaaatcat ttggaataaa ggataaccaa ttattaaaaa taggtgtacc 3071701 tttaacagac ccttattacc gagaaaacaa gaaaaaaatt tcagatactc taaacataca 3071761 aagaaaaaaa ataatcctct atgcaccgac gtttagagat tataatatgc aatcaattca 3071821 attgcctttt acagaagaac aattaattca tcagttaaaa gaagaatatg ttttatttgt 3071881 taagctgcat cccgccattc agaacaatat tgatattaaa tattccagtg attatattaa 3071941 agatgtttct aactatgcct tgtttgatct actcatggct gcagacatat taatcactga 3072001 ctattcttct gttccctttg aattttcgat tttaaataaa cccattcttt tttatactta 3072061 cgatttaaaa ctttatcaac agaagcgggg attggttgat aattatcttt ccataatacc 3072121 tggaagagcc tgctatgaca gtgaatcatt aataaatgaa attcaaaccc catttaatta 3072181 ttccaaaata aaagtttttt ccgatagatg gaataagtat tctgatggga attcaagcca 3072241 aaatttattg aatttcatcg aaaatttaat aagctaaatg atgacacttg ttcaaaacag 3072301 aacaagtgtt cttttttcta ttgaataccg aacgtatgtt tgctttaatg taattagttg 3072361 cttatggcag caaataataa tagaggtggt aaatttatga gaaaaaaaga actgtttgat 3072421 ttcaccaaca tcacgccaaa attatttact gaactacgtg tagcagacaa aaccgtactt 3072481 caatcattca atttcgatga gaaaaaccac caaatttata caacccaagt cgcaagtgga 3072541 ttaggaaaag acaacaccca aagctatcgc ataactcgtc tatctcttga aggtttacaa 3072601 ttagacagca tgctgttgaa acatggaggt catggtacaa atattggaat tgaaaaccgt 3072661 aatggcacca tttatatttg gtctctatac gataaaccaa acgaaacaga taaaagtgaa 3072721 ttagtttgtt tcccatataa agcaggcgcg actttagatg aaaattctaa agaacttcag 3072781 cgattctcga atatgccttt cgatcatagg gttacacctg ctcttgatat gaagaataga 3072841 cagttggcaa ttagacaata cgatacaaaa aataataata ataaacagtg ggtgacaatc 3072901 tttaacctgg acgatgcaat agcaaataaa aacaatcctc tttatactat taacattcct 3072961 gacgaacttc attatttaca aggtttcttt ttagatgacg gttatttata ttggtataca 3073021 ggagatacaa acagcaaaag ctatccgaat ctcataactg tatttgattc cgataataaa 3073081 atagtgctgc aaaaagaaat tactgttggc aaagacttgt ccaccagata tgagaataac 3073141 ttccgtgaac cggaagggat ctgtatgtac accaatcctg aaactggggc aaaatcatta 3073201 atggtgggaa ttacaagtgg aaaagaagga aatcgtataa gcagaattta tgcataccat 3073261 tcttatgaaa acttcatgaa tcatgtacct atgcttcgat cccctttatt aaaaaccgtg 3073321 gggcaccaag atacacctcc agaaagattt caaccattta ttcaaacctt cattttagag 3073381 tataatgctc aaaacaaaaa atggatggtt ccgacttcag gttatttacc atcttacaca 3073441 tcaaatttag tccgaaatat tactatcaat gcagatggaa acttgcaagt cacattaaat 3073501 gaacgctata ttagtttact gcatcaatcg atagaaggag atttccgctt aaaacaaaag 3073561 gatatccgaa tgggatcctg gtattttgcc ggcggagaaa aatcaaatgt gcttgaaata 3073621 ggttttatga aagggagtac aaaaatcaga cccgatgatg cagccatctc aaatgcttca 3073681 agaatgagta tttttatgat tgttgcggac aagattgagg tgtgataatc aaataggctg 3073741 tagctattta atagctacag cctatttgca actttctaag ttttttatcg atattccgga 3073801 acatcggcct actttataga ccagcttctt tcggggcaat atgcataaag aaaagactcc 3073861 agagattgga gtctttttct tttattgcac ccgtatactt cctgcgtatt tatccttcca 3073921 atatgtgctc gtgttcatat tggtaatggt cacgccgttt gataatgtga catgaacaac 3073981 ttgtccgttt ccgatataga tggagggatt taagcttgtt gattgaaaga acacaatgtc 3074041 tcccggcttc aggtccgcct tctcaatctt agttccggca ttgtactggc ttgttgcgta 3074101 tcgaggcagg gaaataccgg ctgctttctg gtatacatat tggacaaatc cagctgtatc 3074161 aaatcccgtc tcaggtgtta ctccgccctg tttgtaaggc acttctccga cataaagcgt 3074221 cgcttcggaa acaatcggat tttctttcgg gattgtcagg ttgtcaaatc ggcgaatacc 3074281 cgtcatcttc gatttccagt aatcctctga caaataggaa atggttactt tttctgaccg 3074341 gcttgcctga atgaacctgc ctgcgcccgc ataaatgcct gcatgtgaaa ttcccgtttt 3074401 atacgtattg ctgaaataga cgacatcacc aggctttatg ttctgagggg ctaccttctc 3074461 gcccactgcc cactgctgtt cggctgatcg cggtagataa atgccgagtg cctgttgaaa 3074521 cacatattgc acaagccccg agcaatcaaa gccctctgac ggcgtgcttc cgccaaacac 3074581 atatgggaca ccgatatatt tttcggcctc ctgaacgaca ggaacatcag ccgttgccgg 3074641 atcggcagcg attcgtctcg ccccgatata agttccgctc caatagctgc tttttttgta 3074701 attggtgatg ataacccctt ttgactgtgt actgtgaacc atttggccgt ctccgatata 3074761 aagggcgtca tgtgtcggaa cagtgccggt gcttccctct ttcttgaaaa acaaaatatc 3074821 acccggcttc aggttttccg gttttacagc tgttccgatt ttatactggt cgtttacaga 3074881 tctcggcaga tgaatatcag ccttactgaa cacatattgt atcaatcctg atggatcgaa 3074941 accctctttc ggcgtttccc cgccatattt atactgatat ccaagcaggt tttttgcttc 3075001 gctgacaatc aattctgatg atgtatcagc ttccgcaatc tccgcttttg tcataattgg 3075061 aaccaaaaaa caaatgataa ccgccacaag caaaaacttc ttccagtttg ccagtgtgtt 3075121 cacttttatt atctcctcct ctttttgcag ttttaacatc ggtatttttt tgaatatgtt 3075181 aagagacttt ttaatatttt tacagaatga atatgctggg caaataaaaa gagagtgtct 3075241 catcagacac tctctttttt gaattattta ttggcgttta ccggttcttc ctgctgctgg 3075301 attttattca tttccatatc aatcttctgt ttttcctgat ctgtcagctg atcattgaat 3075361 ttaaaagctg acataaacat gaacacgatg gctacggcaa caaacggcca gatggctttg 3075421 acaaatttca tctttatcac tccgattatt tagattttag tttgtcacta tgatcaatat 3075481 caaacgtcag ttttccgtct tctactttcc aagcgaaatt agagtctttc gtcagttcgc 3075541 gaataatggt tttctgttta aggctgtctt ttttcacagg cgcaggtgtc gcttcatgga 3075601 tatcgatcgg tgtcacttca aagcgtcctg ttccattttt cttcaggtga tactgaacca 3075661 gtgcactgtc tcttgttctc gtccagcctt ggtcaaagac aaagttgccg aggctgtaga 3075721 aaatgacggt tccgttatat acttcaatcg gttctaagac gtgcgggtga tggccgacga 3075781 tgatgtcagc tcccgcatca gacatggctc ttgcaagctg gcgctggcgg tcatttggat 3075841 cattgtcata ctcttgtccc cagtgtgact gcacaacaac aatgtccgca tgttttttcg 3075901 cttctgaaat catagggatg aagatttcag gatctgcggg cagcacgccc ggcgtattct 3075961 ttttagccgc gaaacctttc ccggacacat cggtaaagcc aagcgtcgca atcgttaccc 3076021 cgttgacttt ctggtacgaa attttctttt tcgcatcact taagctgtat cccgctccaa 3076081 cgatatcaag attttgcttc gcaaattctc caagcgtatc tttcatgccc tgaacgccgt 3076141 aatccattgc gtggttgttg gcgctgttga gaaccgtgaa attcatatcc ttcaagactt 3076201 tcactgattc cttattcgtc tgcagatgaa tctctttatc tgcttgttta taattctttt 3076261 gataggttac cgggttttca aagtttcctg ctacataatc cgaggctcta aagatcggtt 3076321 caacatattg aaaaatactg tctgcccctt tttgctccgt tactttttca acatagcgtc 3076381 ccatcataat atcgcctaca aatgaggctg agagtacgtc gtcagaatac gttttgacct 3076441 tcggcgtttc cgcttttccc gcccacatga aagcgaacat aaggacaaaa acgatcggaa 3076501 tggcaataaa tacgtgctta ttggttttct ttttttgctg ttttgtcagc tttagcagct 3076561 tttcatgaaa gctcagttct tttttcatcg tttgacacac cttacattaa attaagtagt 3076621 aaacaaacat gatagcaaag gtcgctccgc tcaatagcag cgtgcttccg aacgtaatgg 3076681 ttaaaccttg tttctgaatg gtattggcaa ttaaacctgg cacgatgatg ccgattcctc 3076741 gaaattctgc gatttcaaat ggtacaatcg ggtatagaaa atcaaacgcg atttttagga 3076801 cgatccctgt tatcagcatg gcagcgaatt ttctgcgtcc gtacaaaatc ataaatttgg 3076861 ataaaccgta tttcacaatg acatacgtga gcaagctcac tagcaaaaca agtaaaataa 3076921 agaccggctg attaaacaca agtcctaaat atcccggtac aacaagtcct gccggcacga 3076981 tccctgtttt ttccgcaaaa attaaactga gtagtacacc taaaattagt gcgatgtata 3077041 aatctgatcc gaacatgtct gcatttcccc ctagcttacg agctgcttta ccttgtattc 3077101 gtggattttt tcaattaaag gctctgcggc accatgaata ttgccgacgc catatatgac 3077161 acggttgtgc attcttttct ttaacaattc cataatttca tctgttgact tatactctag 3077221 atcatgcagt ttgtctgcag gaattttgcc ttcttcgtag gcttttacga tcggttctgt 3077281 tgtttcaccg attaagatca gttcacttgc ttcaatataa ggcaatacgt catttgcgaa 3077341 ttgctgtgtc cgatcgacac ggtctgcgcg gcagttcatg atgatgatcg gatcatcggt 3077401 cgggtaaccg atttctttta cacgtttcca tatattcaaa gtagaagaag cgtcgtttgc 3077461 ggcaaaccca ttaacaaagt gcccaggctc gctcggactg atcagcggaa gaattctcat 3077521 tgctcccgga tctggcggcg cattcagcat tcccttaaat gctgtttctt cgtcaatgcc 3077581 gagtgcttga gccacaccca gcgccagaga agcgttatca gggaatacca tgtattcaaa 3077641 tttacgtaaa tactcatctg taatttttga gttatcagca atgatgactt ttgtgtttcg 3077701 ttcttttgct ttttgtttaa agaactcggt atattcacta tctgtaatga caagatggcc 3077761 attataagga attgtagcag taaacgcttc tgcaatttca tcaagcgtcg gccccatgac 3077821 atccatatgg tcttccaaaa cattcacaat gacgccgata ttggcctgca gaagttcttc 3077881 ctgaaagatg atttgataat ctgggttaac agccatgcat tcactgacaa tcgcgttagc 3077941 ccctctttct actgtttctc tcatgacttc tttttgctct ccgatattcg gcccctgagg 3078001 tttccgttta atcggctttt cctccggtgt gtcccagtaa atcattcttg catctgttcc 3078061 tgttgttttt ccaacagtct tgtaaccggc ttctattaat attccggttg tcagccttgt 3078121 cacagtcgat tttccgcgga tgccgttaat attcacccga acagggaggg catcaatgtt 3078181 tttctgatgt cgtcgttttt ctaatattcc gatgaccagt atgacagcac aggctataat 3078241 gagtaaccac attgcttttc gacatctcct tctatattgt tgtaaattca ttcatcagta 3078301 tatagaatca ctatgaattc tcaatcggca ttatgtaaca taatcttccc taatcgacta 3078361 agccaaactt ctcttttgaa agagatttta tacctacaaa ctgttttcta tttttggaaa 3078421 acagcaggac ttatacctta tcacttttta aaaaaatcaa agagaatgcg ctttcatttt 3078481 tctcctgata tccttctgga cgtatagtca caccctgctg tttgtattta atatgcattt 3078541 caaatcaatc tttttttcag cctttgttat caagcatttc ctgctatcat gcgtgtttcc 3078601 ggttcttatg aacacaaaat aattttatcc tgtttcttaa ggacaaggtc ataatgtcat 3078661 cctttctgca tggaataagc aatatgaggc ccattccaaa atgactaagg aggttcgaga 3078721 tgaaaacgct aaacatacga gtccgaattc tctaacataa ttaaacattt tctgggatga 3078781 tagtcttttc tgtttctccc catttacagg tctaaacgca tgactttgaa acaattttaa 3078841 taaaacttaa tatttgttca agaaatcttc atccatattt gtgaagactt tgtcaaaaaa 3078901 agagtgaaaa ccttaaattt ttcaattata tatacaattt acaattagat ttcttttgat 3078961 atttttattg ctaacttcgg attgttcatg ataatctatc tatgtaaacg gttacataaa 3079021 caaggaggag ctgttttggc tacaattaaa gatgtcgccg gagcggcggg cgtttcagtt 3079081 gcgacggttt cccgcaacct gaatgataac ggctatgtac acgaagaaac gcgaacgcgt 3079141 gtcatagcgg cgatggcgaa gctgaactat tacccgaatg aagtcgccag atctctatat 3079201 aaaagagaat cccgactgat cggacttttg ctcccggata tcacaaaccc tttcttcccc 3079261 cagcttgccc gcggtgcgga ggatgaattg aaccgggaag gctatcgcct tattttcggc 3079321 aacagtgacg aggaattgaa aaaagaactt gaataccttc aaacctttaa gcaaaatcat 3079381 gtcgcaggca ttattgccgc aacgaattac ccggatctcg aggaatacag cggcatgaat 3079441 tatccagttg tttttctgga cagaacgctt gaaggggctc cttctgtgtc cagtgacggc 3079501 tatacaggag taaagttagc cgcccaggct atcattcacg gaaaaagcca gcgcattacg 3079561 ctcttgagag gacccgctca cctgccgacc gctcaagacc gatttaacgg cgctttggaa 3079621 atcttaaagc aggctgaagt tgattttcag gtcattgaga cagcttcatt ttcaattaaa 3079681 gatgcacaat cgatggcgaa ggagctgttt gcctcttatc cagcgacaga tggtgtgatc 3079741 gcgagtaatg atattcaagc cgctgccgtt ttacatgaag cattgcggcg cggaaaaaac 3079801 gtgccggagg acattcaaat tatcggctat gatgacattc cgcaaagcgg acttctgttc 3079861 ccgccacttt ctacaattaa acagcccgca tatgatatgg ggaaagaagc tgccaaactg 3079921 cttttgggta tcattaaaaa acagccgctg gcagaaacgg caattcaaat gcctgtcacc 3079981 tatataggaa gaaagacgac aagaaaggaa gattaagatg cgtaatattt gtgtgattgg 3080041 tagctgttct atggatttag tggtcacctc ggacaaacgc ccaaaagccg gtgaaacggt 3080101 tcttggcacg tcatttcaga ctgtgccggg cggcaaagga gcaaatcagg ccgttgccgc 3080161 agccagactt ggggcgcaag tgtttatggt cggcaaagtt ggagacgatc attatggaac 3080221 agctattttg aataatctca aagctaacgg cgttcgcact gattatatgg aaccggttac 3080281 acatacggaa agcggaaccg ctcatattgt gcttgctgaa ggcgacaaca gcattgtcgt 3080341 tgtcaaaggc gcgaacgatg acatcacccc agcgtatgcg ttaaacgcgc tcgaacagat 3080401 tgaaaaggtc gatatggtgc tgattcagca ggaaatccca gaagaaacgg ttgatgaggt 3080461 gtgcaaatac tgccattctc acgatatccc gatcatacta aacccagcac cggcccgccc 3080521 gctcaagcag gaaacaattg atcacgctac ctatctgacg ccgaatgaac acgaggcttc 3080581 gattttattc cctgagctta ccatttccga agctctggcg ctttatccgg caaagctctt 3080641 tattacggaa ggaaaacaag gcgtccgcta ttcggctggc agcaaagagg tgctcatccc 3080701 gtccttccct gtagaacccg ttgatacaac cggagccggt gatacgttta acgcagcatt 3080761 tgccgtggcc ctggctgagg gaaaagacat tgaagccgca ttgcggtttg ccaatcgtgc 3080821 cgcttccctt tctgtctgct ccttcggtgc ccaaggcgga atgccgacaa gaaatgaagt 3080881 agaggagctg ctgtcatgaa aaaacacggt atactgaaca gccatcttgc caagatttta 3080941 gccgaccttg gccacactga taaaattgtc atcgcggatg ccggactgcc ggttcctgac 3081001 ggcgttttga aaattgatct ttcactgaag ccgggccttc cggctttcca agatacagcg 3081061 gcagtactgg ctgaggaaat ggcggtcgaa aaagtcattg ctgcagctga aataaaagca 3081121 tccaatcagg agaatgcgaa atttctagaa aatcttttct ctgaacaaga gattgaatac 3081181 ctttctcacg aggagtttaa gctgctgaca aaagatgcaa aggcagtcat aagaacagga 3081241 gaattcacac catatgccaa ctgcatcctg caggcaggtg tacttttcta gaaaggaaga 3081301 tgaaacatgc agattgaaat gaaagacatt cataaaacat tcggaaaaaa tcaggtgctg 3081361 tcaggcgttt cctttcagct catgcctggc gaggttcacg cattaatggg agaaaacggc 3081421 gccggcaagt ccacgcttat gaacattttg acaggcctgc acaaagcaga taaaggtcaa 3081481 atcagcataa acggaaacga aacgtatttt tccaatccga aagaagcgga acagcatgga 3081541 atagccttta tccatcagga attgaatatc tggccggaaa tgaccgttct tgagaatcta 3081601 tttatcggta aagagatatc ctccaagctg ggcgttttac aaacaagaaa aatgaaagcg 3081661 ctagcaaaag agcaatttga caaactttcc gtctctcttt ctcttgatca agaagccggc 3081721 gaatgttccg tcggacagca gcaaatgatc gaaattgcaa aagcgcttat gacaaatgcc 3081781 gaggtaatca ttatggatga accgaccgca gcgttgactg aacgtgaaat cagcaagctc 3081841 tttgaggtca ttacagcgtt aaaaaagaac ggcgtctcca ttgtctatat ttcgcatcgc 3081901 atggaagaaa tttttgcgat ttgcgacaga attaccatca tgcgtgacgg aaaaacggta 3081961 gatacaacaa acatctcaga aactgatttt gatgaagtcg tcaaaaaaat ggtcggacgg 3082021 gagctgactg aacgatatcc aaaacgcact ccttctctcg gtgacaaagt attcgaggtg 3082081 aaaaatgctt ccgtaaaagg gagttttgag gacgtcagct tttatgtgcg ttccggtgag 3082141 atcgtcggtg tttcaggatt aatgggagcc ggccggacag aaatgatgag agcgctgttc 3082201 ggcgttgaca ggctggacac gggtgagata tggatcgctg ggaaaaaaac ggctattaag 3082261 aacccgcagg aagccgtgaa aaaaggtctc ggctttatta cagagaatcg caaggatgaa 3082321 gggctcctgc tcgacacctc gatccgcgaa aatattgccc tgcccaatct gtccagcttc 3082381 tcaccaaagg gtctcattga tcataagcgg gaggctgaat ttgtcgatct gttaatcaag 3082441 cgcctcacta tcaaaacagc atcaccggaa acgcacgcac gccatttatc aggaggaaac 3082501 cagcaaaaag tggtgatagc caagtggatc ggcatcggac cgaaagtgct tatcttggat 3082561 gagccaacca gaggtgtgga tgttggcgcc aaacgagaga tttatacgct gatgaatgag 3082621 ctgaccgaac gcggtgtcgc tatcatcatg gtgtcatcag agcttcctga aattctggga 3082681 atgagcgatc ggattatcgt tgtccatgaa ggcagaatca gcggcgaaat ccatgcgcga 3082741 gaagcaacac aagaacgaat tatgacactt gccacgggag ggcggtaata tgaaaacgga 3082801 acaactgcaa acagaacaaa aacggattca cttcgacgga gtcatgcaaa aactcggccc 3082861 gtttcttggt ttatttattc tcgttatcat tgtatctatt ttaaatccca gctttcttga 3082921 accgctgaat attttaaacc tgcttcgcca ggtcgccatt aacggattaa tcgcgttcgg 3082981 gatgaccttt gttattttga caggcggcat tgatctttct gttggcgcta ttcttgccct 3083041 gtccagtgct ttagttgcgg ggatgattgt gtccggtgtc gatccggttc tcgcgatcat 3083101 ccttggctgt atcattggtg ccgtactagg catgatcaac ggattattga ttactaaagg 3083161 aaaaatggcg ccctttatcg ccacgcttgc gaccatgact gtgtttcgcg gactgacgct 3083221 agtgtataca gatggaaatc cgattaccgg acttggcaca aactacggtt ttcagatgtt 3083281 cggacgcggt tactttttag gcattcctgt accggcaatt acgatggttc ttgcctttgt 3083341 catcctttgg gtgcttcttc ataaaacacc attcggacgc cgaacgtacg ctatcggcgg 3083401 caacgaaaaa gccgcgctca tttcaggcat caaagtgacg cgcgtgaaag tgatgatcta 3083461 ttctttagcc gggcttttat ccgctcttgc aggtgccata ttgacttccc gcctgcattc 3083521 ggcccagccg actgcgggag aatcgtacga acttgatgct atcgcggcag tcgtcttagg 3083581 agggacaagt ctttccggcg gccgaggacg cattgtcggc acgttaatcg gggtgctgat 3083641 catcggcaca cttaataacg gacttaatct gcttggcgtc tcatcatttt atcagctggt 3083701 tgtcaaaggg attgttatct taattgcggt attgttagac cgcaagaagt cagcttagga 3083761 gggttttaca tgaaaaaggc tgtatccgtc attttaacgt tatcattatt tttgttaacc 3083821 gcctgttcgc ttgagcctcc ccaatgggca aagccatcaa actcggggaa caaaaaggaa 3083881 ttcaccattg gcttgtccgt ctcaacgctt aataatcctt tttttgtctc attaaaaaag 3083941 ggtatcgaaa aagaagctaa aaaacgggga atgaaagtca tcattgttga tgcacaaaat 3084001 gattcatcga aacagacgag tgacgtggaa gatttaattc agcaaggtgt tgatgcatta 3084061 ttaatcaacc cgactgattc ttcggcgatc tcaacggcag tagaatctgc aaacgcagtc 3084121 ggtgtgcccg tcgtaacaat cgatcgatct gcggaacaag gaaaagttga aaccctcgtt 3084181 gcttccgata atgtaaaagg cggtgaaatg gccgcggcgt ttattgccga caaacttgga 3084241 aaaggagcaa aggtggcaga gcttgaaggc gtccccggcg catctgccac acgggaacgc 3084301 ggctcaggat tccataacat cgcagaccaa aagctccaag ttgtcacaaa acaatcagct 3084361 gactttgacc gcacgaaagg cctgactgtc atggaaaacc tgctgcaggg acatcctgat 3084421 atccaagctg tttttgctca caacgatgaa atggcgctcg gtgctctcga ggcaattaac 3084481 agctcgggga aagacatatt ggtgatcggt tttgacggca ataaagatgc gctcgcttcc 3084541 attaaagaca gaaagctgtc agccaccgtc gctcagcagc ctgaattaat cggtaaattg 3084601 gctacagaag cagcagatga tattttgcac gggaaaaaag tgcaaaaaac aatatccgcg 3084661 cctctcaaac tagaaacaca aaaataattg tctgatgttt aggaacctgc gataacgtga 3084721 atagagatat agaatgaatt atttctctta cgtgaggaga ggaacggcat gaacaaacca 3084781 acaaaactat tttcaacatt agcacttgcg gctggaatga ctgcggcggc tgctggcggc 3084841 gctggcacga tccatgctca acagccagaa acaacggtaa gcattgatga tttatacagt 3084901 tatccgattg attcttattt ggtatcagca gaggctctaa atgtcagaac gaagccttcc 3084961 gcatcaagcc agaaagccga tacgctgcac ttaggagata gcctaaagct gatttccttc 3085021 tcaaatgctg actgggcaaa ggttaagtat aaaaatggaa aaacaggatt tgtatccact 3085081 cattacattg ttaaagcagc gacaacggta aaaaccaaaa caaaaacaaa agtgtataca 3085141 tccgctgacg gaaagagcat taagactctt ccagcagaca caagcgtttc ttttttaggc 3085201 tggagtaaaa cgaataaagg cggttttgat tttgattggg tattcgttga ttacggcggt 3085261 acgacaggtt atatgaaaac aaaggattta cacatgacaa aataactgag agggattccg 3085321 cataaatgcg gaatcccttt tattatgaat tgatttgtca cattcccaag atatttctca 3085381 ggaaatattg tcgtatgctg tgtcgaaacc ttacatgatc atcgacattt ttgttcacgc 3085441 taaaaagcgg aggtgtaaat atggatcaat ttgaagcagc atatgaatcg tataaagccc 3085501 ggcaaacaac tgccgatcaa gaaaatgttc catctggaaa agaagaaatt attgcggtta 3085561 gaagaaatga ggaagacaat attatcgcag tgaaaaccaa tacaggaaga gagctcgact 3085621 accctactgc gctgtcagaa gcaaaatcag gaaaactcgc tcatgttgat gtcttccata 3085681 aatacgggcg tgacattttg cgaagtgaac cggacggcat caaggaaaat aacctgtctg 3085741 agctgccgga tttttaaaca aatacagccc tgccgtatgt tggacagggc tgtattttaa 3085801 acaaaaggct gctggatgta ttcggctaac cgttttgcac tgtgagaaat atcctctgca 3085861 gctgcataat tcacgccata gaacacatat ggaggcagat acttcatgcc gatcagatta 3085921 ctcgtggcct gaaatggttt caatagctca ctgatcgagt aatgatttgc tccgcccgct 3085981 tgatattttt ccgcttcgct ccctgttgat acagccagca tcagctcctt gccatgcaag 3086041 gcatttcctt ctgaaccaaa agcccagcca taagtcagca caagatcctg ccattttttc 3086101 aagagcggcg gagagctgta ccaatatagc gggaattgaa agacaatccg atcgtattcc 3086161 tcgcacagct gctgttcctt cgcaacatct atcgcttcat ccgggtattc cttataaaga 3086221 tcccgtactg tgatattgtc atgtttactc aattcctcag cccacgcctt attaacaact 3086281 gaggtctcca tatgaggatg cactgccaaa accaatattt tcatcagacc acacctttac 3086341 tgttttgatg ttattttatc taaaatcagg aaaagagcca aataaaaaga aagccctgct 3086401 aaaaggggct ttcttttttt cttttattca gggcttcctt cagttgtttc gatatctttc 3086461 gcaaaatcag ggttatccag attcgcatta aagaaatccg ctgtgttcgg aagtctgaga 3086521 ttcatgttca ttttttgaga aatcgtaacc gtgcaatcct caagcacata gtcaaaaacg 3086581 tgtccgcctg aattgcgtcc ttcgtcaatg aagtgcaggt gatagccaga aacggcgatt 3086641 ccgtttgcat aagctggtgt caagaaacct acaatcgttc ctctcacgtt gtcgaagttg 3086701 aaaatcggct gtgttttgac cgcttcaacc attggcacgt aaggtttttc ttgaagttct 3086761 actgttcttg tctgcacctt tttaaacaat ccgtcaatgc gaattgcata aaataagttt 3086821 ctgcttggca gcatgctgtt gatctctttt tcaaagtctt cgcgtgtcat tttcgcatca 3086881 attttgtgcg tcatgtccgg tgtaaagaac gtaaatgaac agaacggtga acggtctcca 3086941 ttttggaccg gtgtcgcggt tccgtctgag cgaagacggt aaaattcgcc gtcaaaccca 3087001 atcagctctc cgtcaagctt gttaaaggtt ccgataccga agtctccata tttcggaatc 3087061 tctgacagtt caaaatctcc gtcatatact ccgtctaata gagaagtcat tgttgatact 3087121 tgataaatct ggctcacagg ctgatctttt tgaccacggc tgagcacttg aatgttgctt 3087181 tctcgtttca tatttccctt cactcctttt atttagtgct gttcataaaa cagtgtcgtg 3087241 atgcgcagag tgctagagag ctttcgtttt catgagttcc ccgaattctt tcggaagctt 3087301 gtcacttgct aaattaatgt tatcactgta gtcaaccggg acatcgatga tgacaggacc 3087361 ttcagcgttc atgccttgac gcagaacatc tgccagctgg tctggtgatt ctacgcgcaa 3087421 gccagttgct ccgaagcttt ccgcatattt cacgatatcg atatttccga aatcgaccgc 3087481 agatgtacgg ttatattttt tcaattgctg gaatgcaacc atgtcatatg tgctgtcgtt 3087541 ccatacaatg tgtacaattg gtgcttttag tcgaactgct gtctctaatt ccattgctga 3087601 gaataagaaa ccgccgtcac cagagacaga aaccactttt tctcccggtt tcaccaatga 3087661 agcgccgatt gcccaaggaa gcgcaacgcc gagtgtttgc ataccgttac tgatcattaa 3087721 tgttaacggc tcgtagctgc ggaaataacg tgacatccaa atggcgtgcg aaccgatatc 3087781 gcaagttact gtaacatgat catcgactgc attacgcaac tctttaacga tttcaagagg 3087841 gtgcgctctg tctgatttcc aatctgcagg cacctgctca ccttcatgca tatattgttt 3087901 taaatcagaa aggattttct gctcacgctc tgcaaattcc actttcacag catcgtgttc 3087961 gatatgattg atcgtggacg gaatgtcacc gatcaattca agatcaggct ggtaagcatg 3088021 atcaatgtca gcgataatct cgtctaaatg gataattgtc cggtctccat tgatattcca 3088081 gaatttcgga tcatattcaa tcgggtcata gccgatcgtc agaacaacat ctgcctgctc 3088141 tagcagtaaa tcgccaggct ggttgcggaa caaaccgata cggccaaaat attgatcctc 3088201 taaatctcta gaaagggtac cggcagcttg atatgtttca acaaatggaa gctgaacctt 3088261 tttcaaaagc ttgcgaaccg ctttaattgc ttccggtctt ccgcctttca tgccgaccaa 3088321 aacgacagga agttttgctg tttggatttt tgctatggcc gcactgattg catcatctgc 3088381 tgcaggaccg agttttggcg ctgcaacagc acgcacgttt ttcgtatttg tgacttcatt 3088441 cacaacatct tgcggaaagc tcacaaaagc ggccccagcc tgccctgctg acgctatcct 3088501 aaatgcattt gtaacagctt ccggtatatt ttttacatct tgaacttcta cactgtattt 3088561 tgtaatcggc tggaatagcg ccgcattatc caaagattga tgtgtccgtt ttaaacgatc 3088621 tgcacggatc acgtttccag caagcgcaac gacagggtct ccttcagtgt tcgctgtcag 3088681 caggcctgtt gccaagttag aggcacccgg tcctgatgtg actaacacga ctcccggttt 3088741 tccagttaaa cggccgactg cttgggccat gaatgctgcg ttttgttcgt gccgggcaac 3088801 gataatttca ggtcctttat cttgtaaagc gtcaaatacc gcatcaattt ttgcacctgg 3088861 aatgccaaat acatgtgtga caccttgctc cactaagcaa tcaacaacaa gctccgcccc 3088921 tctgtttttc acaagggatt tttgttcttt tgttgctttt gtcaacaccc tcactcctta 3088981 ttatgcattt taaacgtaaa attttaaata tcttgtgata agtttcacta tacactcttt 3089041 ggaaattgac ctccaatatc gattcgcctt atgattaata tgtaatacga attattaacc 3089101 tatggaaagg aatgcatatt gaatggagct tcgccatctt caatacttta tcgcagtagc 3089161 cgaagagctt catttcggaa aggctgcccg gcggctgaac atgacgcagc ctcctctcag 3089221 ccagcagatc aaacagctgg aggaagaagt cggagttacg cttctgaaaa ggacaaaacg 3089281 atttgtcgag cttaccgcag caggagaaat ctttttaaat cattgccgca tggcattgat 3089341 gcaaatcgga caaggaattg aactggcaca gcggacggcc cgcggcgagc aaggccttct 3089401 cgtaatcggt tttgtcggat cagctacata tgaatttctg ccgccgattg tccgggaata 3089461 tcgtaaaaaa ttcccatctg tgaaaataga actgcgtgaa atatcctcgt ctaggcagca 3089521 ggaggagcta ctaaagggca acattgatat tggtatactt catcctccct tacagcatac 3089581 agctttacat atcgaaaccg cccaaagcag cccttgtgtt ttagctttgc ctaagcaaca 3089641 cccattgact tctaaggaat caattacgat tgaggattta agagatgaac caattattac 3089701 tgttgctaaa gaagcatggc ctactctata catggatttt attcagttct gtgaacaagc 3089761 gggcttcaga cccaacattg tccaggaagc cacagaatat caaatggtga ttggtttagt 3089821 cagtgccgga attggtatga catttgttcc ttcctcggcc aaaaaattat ttaatttgga 3089881 tgttacttat cgaaaaatgg accaaataca gcttaatgca gaatgggtta tcgcttaccg 3089941 caaagacaat cataatccgc ttataaagca ttttattcat atttcaaatt gtcagcagac 3090001 aagaactaaa gagagtgatg caggtacatg aacaatactt gcaatctctt ttttcttttg 3090061 ggattcttat ggaattttta ttaatttaat ataatcgctt agtacaactt tatatcagta 3090121 tacgtataca tacagtacaa atagttggca aggacatcag taagcgcagg acattagttt 3090181 gattttaaaa atgaaagata gagaggtgaa gtaaattatt gagttcaccg gcatattcac 3090241 attgctcgct tttttcgtaa caatgatttt tattttctgg agaccaaaag gactaaatga 3090301 agctatcccc gccacatttg gcgctttaat ggttttattg tgcggaagtg tgtcattggc 3090361 agacttaggg gaaatcggaa caaaagtcac gggtgcatcg gttacaatcc ttgccactat 3090421 gattatggcc attgcactag aaagctttgg tttcttttat tgggtggctg caaaactgct 3090481 ccaacaatcc aagggttcag gcatcaagct tttttggcta accaatttgc tctgctttct 3090541 catgaccatt ttccttaata atgatgggag cattttgatc acaactccaa tccttttgct 3090601 tgtactaaaa tatttaggtt taaaaaaaca tcaaaaagcc ccatatttat taagcggtgt 3090661 tttaatagcc acagcctcta gcgcaccgat tggcgtaagt aatattgtta atttaatttc 3090721 tctcaaaatc attggaatgg atctatatct tcacaccgcc atgatgtttg tccctagtat 3090781 gatgggactc atttttatga cttgtctact gtttatgttc ttttataaac gtcttcccaa 3090841 aagcctgcca gatataccgg gccattttca gtctctgcgg catagaaggt accatcctct 3090901 tcattcgcca tcagctcctt taccagaacg aaatcaaaca aaaatcatgt tgtttgtgct 3090961 tgcatttgtt tttctcgtca gaatgagtct atttgcagca tcatataccg gtatttctgt 3091021 tcctctagtc gctgtcatcg gatcttttat cctgttgagc tggagatgga tttatttcaa 3091081 aacctcccca agagacttgt tatataaatc gccttggcac atttttatat tcgcttttac 3091141 tatgtatgtc ttaatttatg gtctgcataa tattggattc acagagttac ttgtgagtta 3091201 ttttgaacct gtggtttctg gaagcctcgc ccatgcaact ttcgcatcag gtatctctac 3091261 ttcagttttt tctaatctct ttaacaacca tccagcgtta atgatcagta cttttacctt 3091321 aactgaaatg accctgaatc cttcaacaac aaaaatcatc tacttggcaa atattatcgg 3091381 cagtgatatc ggttcattat tattacctat gggaacctta gcaacgctta tttggatgca 3091441 tatattaaaa cagcatgatg aaagtatttc atggggcgaa tatataaaaa cgaccattat 3091501 catcattccg ctgactgttc tttttacgtt aacatgttta tatttttgga tcagttggtt 3091561 atttctttag cacagtatga aacgaaaaac tgccttctgc ttttcaagag ggcagttttg 3091621 tatacactag ggaagatgca ttgtctttag atgatttaac ttccaaatga ctggctctcc 3091681 acttgcgtta ataagctcaa tgatattatt agagacaccc tttaatagtc cgactttttc 3091741 tggcacctct cccatatcaa atatgaccaa ttcaccaata ttttttttga tctgctcctc 3091801 aaaattacgc acaagaggaa ctttggaagg cacgaccggc aattgtgagt tgtcaagagt 3091861 atacggtgtt tgttcagttg aataaggggt aaaccatttt aaatgatgca tagatataaa 3091921 aagtatttta aatacgggtg agaaaaatac aatataatcg tttaaaacat ttgtaacata 3091981 tccatggatc gatcgacccc cagttacata aacttcaata aactggcctt tgaccttgtt 3092041 taatgtattt ctatatgaaa aagcttgagt ttctgcctct atcattggat cttccggatt 3092101 gatcaaaaat ggcttctcag tactggtcac tattttcgcc ttgtttattt gatgaagatg 3092161 caacaaggga atataaagat aattgcagcc atcaaaaata acaaaaatat cctgtccgat 3092221 atctatgagg gtgccgacaa accttgtatc tcctgaaatg acaacctcaa catctgtgtt 3092281 aaggaattga ttcaaacctt tcacgattct cctcctttaa ctgaaaaagg gcatcacttt 3092341 atctgatgct cctccattat ctattaaaat ttacgtttcc agtgatagtc tatcgttctg 3092401 acaatcgttt catagctata atcttccttt tgttttcctg aactttttat tgaacttgaa 3092461 tagcctggtg atcttgatga ttgataatct gaagatcttg gtgatcgttt agatgatttt 3092521 gatgattgat aatctgaaga ttttaatgat cgtttagatg attttgaaga actttttgaa 3092581 cgtgacgaac ggccagattt ggatgattga taatccgaag attttagtga tcgtttagat 3092641 gattttgaag aactttttga acgtgacgaa cgaccagatt tggatgattg atcatctgaa 3092701 gattttagtg atcgtttaga tgattttgat gagctatatg attttgaaga aatgaacgaa 3092761 ttgctgtcct tatcattatt gtcttcctgg ttttgttcat ttttttgatc ctcttttttg 3092821 tacgaccctt ttggacctaa gctgatgctt tttatgtgaa aaggatagat gcgaagcacc 3092881 tcttgatttt tcactatagt ataatggccg tcggcattat ctacaaggat accctcaatg 3092941 gcttccggac ctccacgatt aattgaaacc catttatgag tcagactctt aaaaacctcg 3093001 cttaaatcat cagcttccaa aactccaact ggcgtctgct cttctatttt caaatcaggc 3093061 tcgtgtttac ttatactttt gatgtgatgg atattaaaat acactacccc atcctcattt 3093121 gtgtttaacg cagcgtaatc atctcccagc cagaccaatc ttcctttttt agattccgga 3093181 cccccttggt taaattgaac tgattggttt attaaatgtc cgattaagct atgaaaatca 3093241 tcagcatcga gcatttcctc agtctcaatt gttgtggtgc tattattggt atcctcagta 3093301 atacttttca catgctccaa ctgataataa attatttttt tttcagcttg taaagctata 3093361 taatctgatt ttacagctgt taattttcct tttttagatt ccggacctcc acgatataca 3093421 gtaacaattt tatctttcat tgagtgcaaa aagttataat acgatatttc attatttgaa 3093481 tgatatttca ttctcctctt gctcattcaa attcctccta gtcacttata catagatgat 3093541 aaacatactg catatatacg tgtcacattt atttgttgaa ctaattcaat agcctaattg 3093601 tcgctttttc cgcgaatacc cattttcacg cattcataaa atacttaaat gatctttgag 3093661 gtattgtgaa cggtttttaa tatactcgca gatcacatcc ggctcacggt caaaacgctc 3093721 aatatcattc tttttatacg ggtccatgag gacaaacggc ctaatccgtt catacatcgc 3093781 catgattttc ggttccatat attctattgt aaaaagagat tggagcgttt tttctaacag 3093841 gcgcttgtag gacttgcgaa actcggattc atccaatatc cgggcggtta gtgtattaaa 3093901 tccttgaatt cttacataat cggcagccat ccgctctcca tggatatccc tgccccaagt 3093961 cgcatcataa tcccaaggaa tcacctcaaa taatccggtt tccccgcttc tgtataatgc 3094021 gtagttgtgg acaaacccgt catagttcga ggtgaataca ataccagcaa gccagcgcaa 3094081 atacttatcg acatccacgt gttttgtcac ttctgactta aactgagctt tagggaccgt 3094141 attaatttta aaaatcatat cttgtaaata aaaatcatct tcctcagtcc ctgttttctt 3094201 ttcatatcca agctccagcg atgttttcgt ttccctttct aaatcgctca tcagagaaaa 3094261 gttggcatca tcatccaccg cataaaaaat cgcgccatca gccagcttcc ttttcgccaa 3094321 ataatattca tctacggatt caagttcaag ataaacccct tcattcttcc cattcatctt 3094381 tacaaacgca aactctgcct ttggagacag tgtccctagc tccgagaaaa aatccagaga 3094441 caatttgttt ctcatcaagg aagggtcttt atactccgca tttaagtgaa tctctcgcgc 3094501 gccgcggaat gttttcggct gataaaagga aatatggtat gacttctttt tgaagtctct 3094561 gatatgtgat ccccgataag cgatatcaat atccagcctt ttttgattta ccttcatcac 3094621 agctggcacc ggatcatcgt cccatatatc cttttttaat tcacgcaagt cttttggatg 3094681 aacaaacagc tgataaagcg gtaaattgga ttgattcttc atccataatc ctccttacaa 3094741 attttaggct tttattttta taagatctca gcggaacact tatacacttt ttaaaaccgc 3094801 gcgtactatg agggtagtaa ggatcttcat ccttaacata tttttaaaag gaggatttca 3094861 aattgggcca ctattcccat tctgacatcg aagaagcggt gaaatccgca aaaaaagaag 3094921 gtttaaagga ttatttatac caagagcctc atggaaaaaa acgcagtcat aaaaagtcgc 3094981 accgcactca caaaaaatct cgcagccata aaaaatcata ctgctctcac aaaaaatctc 3095041 gcagtcacaa aaaatcattc tgttctcaca aaaaatctcg cagccacaaa aaatcatact 3095101 gctctcacaa gaaatctcgc agccacaaaa aatcgtaccg ttctcacaaa aaatctcgca 3095161 gctataaaaa atcttaccgt tcttacaaaa aatctcgtag ctataaaaaa tcttgccgtt 3095221 cttacaaaaa atctcgcagc tacaaaaagt cttactgttc tcacaagaaa aaatctcgca 3095281 gctataagaa gtcatgccgc acacacaaaa aatcttatcg ttcccataag aaatactaca 3095341 aaaaaccgca ccaccactgc gacgactaca aaagacacga tgattatgac agcaaaaaag 3095401 aatactggaa agacggcaat tgctgggtag tcaaaaagaa atacaaataa tctaagtttt 3095461 cattgtttca ataggctgcc ggcggaggta cggaagccta tttttttatt tgccctgtat 3095521 tagatatatg tcatgacata acatatgcaa cccgcatcat ttggtttcct ttaaaccatt 3095581 tcgttataat caaggtatcc taacgataaa ggcggttgtt gctatgtaca tatttcaagc 3095641 tgatcagctt agtgccaaag acacatacaa gctattgtca ggtaccgtta ttccccgccc 3095701 cattgcattt gtgacaacac tttcttcagg aggagcggta aatgccgcgc ctttcagttt 3095761 ttataacgtc gtcagctcag atcctccgct tctcagtatt tctgttaaca ggacggaagg 3095821 acgccaaaaa gatacagcac gaaacgcagt ggagaacgga gaatttgtcg ttcatgtcag 3095881 tgatgaagcc atcattgaag atatcaatga aacagctgca agcttaaggc cggatgaaag 3095941 cgagcttaca cgcacctcgc ttcatcctgt tgaaagcaaa gctgtttcag ttcccggcat 3096001 taaggaagcc cgcgttcgct ttgagtgcaa attagagcgg catattacct ttgacaatga 3096061 tcaaggcatc actacagcag atctgctcat cggaagagtt gtctgcttcc acctagatga 3096121 aaaggtgtat gatgcagaaa agggatatat tttaacggat gaattaaagc ctgcctcacg 3096181 attggcggga aatcactatg ccaagctggg ggaagaattc acactgattc gtcccagctg 3096241 aagagaagga ctatttaaat agaagaaact agtcaaaaag accttatgat tacaaaatat 3096301 cgcctgtaaa taactgaaaa aatatcaaaa aaaagaacac ccagagcaag ctcggggtgt 3096361 tcttttatga aacgtttttc ctttttcttc gtataaaggt agattaggag gaattggaat 3096421 gacaaacttt tggattttaa tgctgatcgc tattaccatc agtctcgcct ctcaattttt 3096481 tataaagaaa aaatacggta ttgataaatc cggctggcga tataagcatg tcagcaatac 3096541 acacaaatgg atcgaaatca ctttacttat tttgtttgtg ttttcactct ccttttttcc 3096601 agttgaatat ttgcttcttt tattttttat tgtgattgac tcaatacgta tttttatgga 3096661 gtggcattat agacctgaag ataaacagta tatgtaccac attgtagagg tctcccttat 3096721 gtttatgctt ttgatttatg tttgtaccct atagttattt aaatccccac agccgctccg 3096781 tctccccgag gatcggctcc gccttggaga aagccttctt catcaacttt gattgcagcc 3096841 gcttgtccca tcagcggatc atagtcaccg acaacctcca cgagatgccc gctgtctttc 3096901 agtttttgga ttgttttgtc tgtgaatctg ccctcgactc tgagaccttc gtattcctct 3096961 ccccacgttc tgccccatac ccagcgcggt tcgctgattg cctgctgtgg atgcattccg 3097021 tagtccagca ttcgggtaat gatggccgtc tgggtctgcg gctggccttc gccgccttgt 3097081 gtgccgtaca gaatttttgg ctttccgcct ttacagacca tagccggcat caacgtatgg 3097141 aaggtgcgct ttctcggttc aagcgtgttg acatgatttt catccagtga gaaaaacgat 3097201 ccgcggtttt gcagtaatat gcctgtatca ccggcagtga ctgccgagcc aaattcaaag 3097261 tacaggcttt gaatgaatga cactgcgttg ccatccgcat cgattacggc cgcatatgcc 3097321 gtatcacttc ccaccggcct gctttctgcc ggtattgcga gatagccgat ttcttctgcc 3097381 aattgttttg cataacgttt gtccaaaagc ctttcaagcg gaatgtctgc aaacgccgga 3097441 tcagtcagga cggcatcccg atctagaaaa ctctttttca atgcctccac aagcacgtga 3097501 taatactcaa atgaaccgtg ttcgatttgg gtgaaatcat agttttccaa aatgttcagt 3097561 gttaataaac cggtaaatcc ctgagaattc ggcggcgcct gatacacact gtatcctcga 3097621 taatcacttg atacaggcgc tgcccactca ccccgatgcg ctttaaaatc atcgattgtc 3097681 atgtaactgc cgttattctg taaatgtgag acaatccgct gagcgagatc tccttcataa 3097741 aatgcgcttc ttcctttttc agcaatcaag ttcagactgt ctgcaagctc tttttgcaca 3097801 aaccgctctc ccgggacagg tgctttgccc cttctcgtga agatgtcagc cgtgtaaggc 3097861 gtggaagcca gcagttcaat attcttttct gtgtgacgac actgatcagc tgatacagga 3097921 aacccatttt gggcataatc gcgtgcgggc tccaatacat ctgcaagaga cagacgcccg 3097981 tactccttca ggaccgcatc ccagctatca accattcccg gcacggtaat agcactgtca 3098041 attccccgca gcggaatcgc gctttttccc ttatatacat ctctcgttac gttttttcct 3098101 gaacggccgc tgccattgta gacttttact gcctttgttt cctggtgaaa ggtcagccaa 3098161 aaggaatccc cgccaagtcc ggtcatatgc gggtacacaa ccgcaagaca agcactcacc 3098221 gcaacagcgg cgtcaaacgc gttgcctccc ttatccagta tgcggtttcc ggcttgagaa 3098281 gcgagataat gcggactgac gaccatttgc tttgtaccga tgacagattt gttcatcaca 3098341 agtccccttt tttaagaaat tttcttcagt atagggagcc tgatttttca catctactga 3098401 tccggcagaa aaactgacga actttcttct tttcgcaaat aataagatat tttcgcattc 3098461 atttcgaaaa caaatgaaaa attattattt ctatacgtaa cttttatgat aaaatgattg 3098521 ctaaaaggct acgaaagcag gtggagcaat tgagtcatga atatcaaatc cccaaccttg 3098581 tacttgatga gactgataaa caaattctca cgattttgca tgaagaaggc agaatttctt 3098641 atacggatct tggcaaaaga gtcgatttgt cacgggtcgc cgttcaggcc cgtatcaacc 3098701 aattaattga agccggtgtt attgaaaaat tcaccgctgt catcaatccc gctaaaatcg 3098761 gcatccatgt ttccgtgttt ttcaatgtcg aggtagaacc gcaattttta gaagaggtcg 3098821 ctcttaagct tgaggaagag cctgcggtca ccagccttta tcacatgaca ggcccgagca 3098881 agctgcatat gcatgggatc tttaccaacg atcaagaaat ggaagaattc ttaacaaaac 3098941 ggctgtatcc attgcgaggc gtcgtcagtg ttgattgcca gatgctgatc aaacgataca 3099001 aaagccgtat gggaatgaag ctgtaaagga gagaaacaaa tgaaaaacca tccttatcgg 3099061 gatatgacgg ccgcaatggt tcgcaccggc atattagggt tcggcggcgg accttccgtg 3099121 attccgctga tccgccatga agcggtcaat aaatataaat ggattgacga tgatgaattc 3099181 ggagaaatat tagcaatcgc taatgcgctt cccggaccga ttgccaccaa aatggctgct 3099241 tatctgggct ttaagctaaa aggcacatta ggtgcaattg tggcgatcct cgcccacatt 3099301 ctgcctacat gtcttgcgat ggtgggcttg tttgcggctg taaatgtgtt aagccattca 3099361 gcaattgttg caggtatgat tggtgccgtc acgccggtaa ttgcggtcat gctcggaatc 3099421 atggcgtacg agtttggcca aaaagcgctt aaaggtttcg gctgggttac cggcatcctg 3099481 ttttttatca tcgcttttat cggcctgcaa actttacaga ttaatcccgg cctggtcatt 3099541 atcattttct tagcttacgg ggcgtttcat tttaaactga aagacaaaat cacaaataaa 3099601 cattcaaaag ataaaggaat gtcagcctca tgatatcgat ctatttattt atggcgtttt 3099661 ttatcgcaaa cctactggga tatggcggcg gacctgcgtc tatcccgcta atgtttgaag 3099721 aagtcgtaaa cagatacagc tggctctcaa acgatcaatt ctcaaatatg ctcgcacttg 3099781 cgaacgcatt gccgggcccg atcgccacga aaatcgctgc gtatgtcggc tacagcgcag 3099841 gcgggtggcc cggcttccta attgccctga tcgcaaccgt cgtaccgtcg gcgctcgcat 3099901 tgatcgtcct gctgcgcatc atccagcgct tccgccaatc acctgtcatc aaaggcatga 3099961 cgctgtccgt ccagcctgtc atcgcggtca tgatgctcat tcttacctgg caaatcggcg 3100021 cagacggcat caaagcgatc ggctgggtcc aatcgatcgt gattacggga atttcgctcc 3100081 ttgccatgac aaaattcaaa atgcatccgg catttttgat tattgcggcg tttttatatg 3100141 ggggccttgt gatcccttat ttatagaaaa aagcacctgg acaggtgctt ttttatttta 3100201 gcccagaaat gccgtttgat atgacagctg tttcttctcc tgcgtcactc ttgatcatgt 3100261 gcttgacttg cagcgtggtt cctgccattc tcacagattg cttcaactgg gacgaattgg 3100321 tttcaacttg tatccaaaca ggaggctgga ccttccaaaa taaatagagt gcaagaatca 3100381 gcaagccagc aatgaccgac agcaaaaact tcatatcgca tcgcttcttt tcagtaagcg 3100441 gctcgcagcg gacagcgcct gatgatcacg aagaatatcg cctggacgat tgccttctcc 3100501 cagcacatag cctttaaagg acattcccat aaaatgaaaa atatgttcga attgctgaat 3100561 cagcggcagc ccttttattt ttggattgtc tccgcccact gctattacat atgcctgttt 3100621 cactgacatt tgctgtttaa aatcaggaaa tctcggatct ctcaacgtct gtgaccagcg 3100681 atcaataaac agctttaatg tccctgacat gccaaaccaa taaattgggg tggcgaatat 3100741 aagaatatgg cactgcaata tccgttcaat gatagaatcg tagtcatctt gaacaggacg 3100801 aaagccgcct tgggcgtgac gcagatcttc aattggttga attggatatt tctgcaaata 3100861 aatgtgctcc gcatcgaatc cttgaacagc cttctccgca agaacatccg tatttccgcc 3100921 agaccgagtt ccgccgttaa taaccgcaat tttcatgatg catctgctcc tttgtttacg 3100981 aatgattttc ttcatcatat aatggattca tcaatcaata cagatgatta tttcgattaa 3101041 tccaatcgct aaaaccgatt tagaaaggaa gagaacaagt ggaattgaag cagctgatca 3101101 cctttattac ggcggctgaa catgtaaact tcaccctaac cgccaaaatg cttaattatg 3101161 cacaatcaag cgttacctct cagatcaaat cacttgaaga agaaatcgga acgcctttat 3101221 ttgaacggct cggcaagcgg cttatcttga cagaagcagg aaaaacgttc aaatcttatg 3101281 cacagaagat cattgcgtta acagaagaag cgaaaatggc cacaaatcaa gtaagagaaa 3101341 caaccggaac cttaaaaatc ggggcgacgg aaagccagtg cacataccgc ctgcccccta 3101401 tcataaaaga atttaaacag gcttttcccc aagtaaagct catattcaaa ccatatatct 3101461 ccaatgaaca agcgaaagaa cagctcttac agggccagct tgatatcacc ttcatcttgg 3101521 atgtaaaccg gatggaagac gcactgcacg ttgaatcttt gattcaggat gagatcaaaa 3101581 tggtggctgc taatgaccat ccttttcctg cggatttacc agtaacattg aaggatcttc 3101641 aaaacgaaac tcttctgctg acagaggacg gctgctcgta ccgcacgctc tttgagaaca 3101701 atttgcatga ctccggtatc tatcctaaca aattggaatt cgtcagcata gaagccatca 3101761 aacaatgcgt gatggccgga cttgggattg gaatcttgcc tgaaatgaca gtaaaagatg 3101821 atattgcagc aggccggatg aaagaactca attggcagag cgattgcccc gttttcactc 3101881 aattagcatg gcataaggac aagtggatgt ctgcgccatt aaaggctttt atcgatttga 3101941 cacggaaaac attcaaataa aacctctcca caaggacgac aaggtttttg agaccagggc 3102001 acacacatac aaaaaaaaca cttgatgact tagagcccca agtgttacac gtgatttttc 3102061 tgataaaacg ttcgcaaaac atgcgtctca aggtcagcca ggcggacagg gatcggcagc 3102121 ctgctttctt gattgatcaa gctcatcgtg atctgatagc tgctgtctaa atcaatataa 3102181 ttaccgcaag acaagaaaat aggcttcacg tcccgccgcg ttcgcagcgc ccgtccatat 3102241 acctcgccgt caatgataat atcggtgtat gcgcctactt caatttcagg cgtcacgaaa 3102301 tcgcagcctt tgattttgag ataggttttc gctatcccaa tcgtcggctt gcccagaaaa 3102361 aaagccgcat gggtggcaac gcccatatga ttgtaatgca gatatccgtt gccatcaaac 3102421 aagaagacat ccggctccgt ctccagcttt ttcgccgcct cgatgatcaa gggcagctcg 3102481 cgaaacgcaa gaaaaccgga aacatacggc acgctgattc tccccatgct gtgcactttt 3102541 tcaatgactt cttttgtatc agcgtcaatt acgataatac agcacactcc gtatggttct 3102601 ccatcctgct cccaataggc caggtcgacg cctgcgcagg tgttgatgga gtctggatgg 3102661 atcgtggggg ataggttgat acgattttta aggttaaatt gcacttgtaa aaagtcttgt 3102721 tcctttttca tatcaaattt atgcacatca aataccttca taacgattgc tcactctcga 3102781 cctaaattaa tgtgagtctc tcttctcgat tctagtattt caaaatgagg actatctgta 3102841 tctatctcgt acttatttaa tagattgcct tcttcatccc aattcttttc agaaattagt 3102901 atggaatgct catactgttg ctcacttttt ttcctgccat tttcaaacca aattatgctt 3102961 ataccgtgca attgcccata tcggtattct ttttcacttt ttttattccc gttttcataa 3103021 aattcacatg ttaaaccatg ggccagacca ttcttatatt tagtaaaata gatgatttga 3103081 ccatttggat ataattcgta agccagccct gtaaacggct ggccattttc gtcttcagga 3103141 ttatctaaaa tctcatcact taccgaagag aaccataaat cctcaaagtc cactcccttt 3103201 tcttttatac tcttcatatc atattcattt tccatacttt aaagcctccg gtatataatt 3103261 tgtattttga gttatatatt cacaatgtgg acatctaggc attgggacac cttctggcat 3103321 ctttttattt attttcctag cacttactac atataccatt aaatctttta aatccgcatc 3103381 aggtctttga agtaacgctt catttagagc attaacttcg gcatgagaac ccgcccctga 3103441 cgtctttata taaccttctt taagttctgt aggcatattt acaattctat catgaataag 3103501 tggatgtagt accttaggtg gcttcccatc tatattgttt attccaaaat aataattgcc 3103561 tgtttttttg tccaatacac cagctaccgc agggcctctt tgttttttag ttagaccaga 3103621 agatttaatt ctactaagtt cgtttagtac ttctgccctt agatttattc gatggtgaag 3103681 atcttcttta gacaatacac catgcttatt tcttaaatat tgaagcctag tttgtttttc 3103741 ttcagtagtc ttagcaatat tgctaataag gctttcatta ctcactttat tgacatatgg 3103801 agcatttttt tggtacaacc gatcaaagta gtgtgccaat cctgctccac caataatagt 3103861 aatagcttcc agcgcccctt gcttccgctt ctcctcagac actttgtttc cgaacatatc 3103921 ccggcctgtg acagcttctg agaatccgtt tgacgcaaca aggccgtatg cgcccatttc 3103981 tgtcattttg agaatgtcta aggatttgcc tgttttgtag gcgtctaatg cgtgttcagc 3104041 agcgatagct gcttttccgg ttttgtagat ggcttttccg cctttgaagg cccggcctgc 3104101 ccagccgacg actggtatga atccggcagc ggccatagct cctgctgtca cacgctccgc 3104161 ggtggagagt ttttctccgg taaccggatc aacgccttcg gttgctcttt tataatcata 3104221 atagccagtg acttctccag taaagttgca aactccatcc catgtttttt cgtaccacgg 3104281 tttgtttgct tcttcctcgg ctttttcctg gagccgtctt gcttctgctt gctgggtttt 3104341 tgcatcgata taggttgttc cttgattttc tacttcaatg acgcttttgt agacttcatt 3104401 gctgtggaag gcttttttgt catagtacat aggggatgcg ctcttcccat tgctggtggc 3104461 ctgcatgaga acagaatatt tggtgagcac tgcgttgtcc agagattcta aattttgata 3104521 ttcagtggtc agggattcat caagcttatc gacagctgtg attgtatcac gtctgatttt 3104581 ttgggcatcg cccatcttat ctgcatagtc gtcaagcgtg tacatgtcga gatcaataat 3104641 atcgctgatg cctgacaaaa tagaatcgat ttcttcttta tgagcggaga caatctctga 3104701 ggctttcagg tctccattgg gcagctcatg atccaaaaaa gaagtttcca catatgaatc 3104761 attcagttct tgatctttaa tatctcctga aatgccgttt aaaaacgcaa tttgagcaga 3104821 gacaagcgtc agccagctgt ctacgatttc tgcctgtccc tgaaaaaaat ctttaatatt 3104881 gtccgcgcca tttcctttaa aattatcgcc taaatcggca actccctgaa acgctttttt 3104941 cagcgtattc agctgctctt caagcgtctc atattgcttt tttctgctct tcgcttcttc 3105001 gattaaagat tttgattcaa atactttact catcgcactg ccctttctgt tctattttac 3105061 cgctatcgcc tcgtcctgct ctttgagtga atctacgtta tcctttgtat cctcgatatt 3105121 tttctgtacc gcttttttgt aatctccgag catggttttg atgttctcct cacgctcatg 3105181 gtattttttc gtataatcga ggctgttttt tccgttggat cctgcggcgc cgattgatac 3105241 gtcagcaagc gcatctttga cagaatctaa tgttttgatg actgtgtcgt acttcagctt 3105301 aatttctgac ataaaaaaag atcaccacca ttttagttta ctaattgtat ttccgacttc 3105361 ttccgcgaac tcttctccct ttttaagaag atctgctgca ccatttgcta tgaacaattc 3105421 cgatgcatat ttagctttat cccattcaag atcaaaaatt ttcccgttaa tcgaagccat 3105481 atactcgtta tatttatcat tcacaatctt agatgcttcc gatttcgcct cttctcttcc 3105541 cttgtcgaaa tcatcggctt ttgttcccgt ccaatgcttg cccaattccg gtttcacaat 3105601 ttctttgatt tcagtgattg cctcttcttg cagtgtgtct atgtcctttt ttgctttttt 3105661 cagcttttcg atcttgtctt ccacgtctga aatttttccg ttgagcgaac ttttgatatc 3105721 cgctagcata ctttcataac ccatctgaat cacctcttaa tactcaaaaa gtcgtatgga 3105781 ggggctgatg aagatagact tttccatact ttatttccat atattatatt ttaaaatagc 3105841 cagaaggcgg cttaaatagg gtaaatggct taatttaggc atataacgct cttgaaatgt 3105901 aggtatttga tcttgttttt gttcgttata cagctaataa aagcgtttta taaaatgaaa 3105961 tcacctaatg tcatagttat aaaggcactt gaaagaggca gatgttgttg atctgcctct 3106021 ttcggcgctg agcttattgt tcatgtttat gttcttcatc tggtcggcca tgtctgattt 3106081 tgtcatttgg cttctattat tccccccttc tgaccctttg gatcaaaagc ttgtattagc 3106141 tgcagtccca gttgtacaga acgtttgaaa agtctttttt ccttagatct tcaggtgtga 3106201 tgaaaaaatt ggcgatgccg acgtctcccc acattgaatc gatatcatcg tctgaatcaa 3106261 tttgtaacag catgatggtg tgttctttat atgcgtattc ccggggatca tgctgggtaa 3106321 aagaagcgta tccgccaatt ttatggccaa atccgttttc agccagttca ttataaatgt 3106381 cttcttcatc ctcgccgaac tgaccaaaga actccattgt ttccatgccc gtatactgct 3106441 caaattgaaa atctgtaggc agcacccatt ccgaagattt cacaggctcg actgccgctt 3106501 ctgataaaat cggaaaatca cattcgcctg tgccaataaa tgaaaaatca gaaacaagct 3106561 cgtcatcgtt ttctacgata ttttcaaaat agatcactct gaaattcttt tgttcacatc 3106621 gatcgtcaaa attcaatcca tagacgtcat catgaacaga aatgtagaac tgcaggatac 3106681 ctgaagaagg gtagccgtca agctggggaa tgtgcgagaa attaatctgc gccagaagtt 3106741 tcatcggctg tccattttcg tcagtcggat atgtttcatg cttggggaaa tagggatcac 3106801 cggcaatttt gctgtcatat cgtcctgttt tcccctttct cacattcagt ttcacgtatt 3106861 ctttcgctga tttctccagc aagtcgcggt acggtctcat tttttcgggc agatgattca 3106921 tcagattctc tccttttccg gcatctccaa ggttttattt tctggttttc ttctaatgtt 3106981 tttcaaacga atgtttaaag aagccctact tctgcataat tttccaaaca atagttaaat 3107041 agtagcaaat gtattcagca ccccgcaata gatgaaaaaa agactggtgc gcaaccagcc 3107101 tttctttttc atctattgaa ttgcacctga cggaacaacc gccttccgtc cgacagaata 3107161 atactccact cctgcagcca aagcctcatc caatgtgtag cagtttctgc cgtcaaatat 3107221 gagcggcgtt tccatcaaat cctgataagc cgctaacggg aattgtttaa tgtcagccca 3107281 gtcggttaaa atcatgacgg cgtcagaccc tttgacagct tcctcgatcg tctctttata 3107341 ttcaacagct tgcgggagaa catgctttgc atggctaact gcaatgggat cgtaggctct 3107401 gatacgggcg tcgagcgcag cgagacggtc tgcaataaca attgacggcg cttctctcat 3107461 atcgtcggta ttcggtttaa atgacaggcc taaaagggca atcgtttttc ccgtcacccc 3107521 accgagcctg ttcagcgctt tatcaaccag catcgcctgc tgattgttgt tgactttgat 3107581 aacggatttc agcagttcaa aatcatgctc gacattgccg gcaatttgca cgagggcgtt 3107641 tgtgtccttt ggaaaacaag agccgccgta gcctatgccc gcttttaaaa actggctccc 3107701 gatccgctta tcctgtccca tcccgtatgc gactgcttca atatcggcgc cgaccttttc 3107761 acatatattc gaaatttcgt ttataaaact gatcttagtg gccagaaaag catttgaggc 3107821 atatttgatc atctcggcgc ttctgatatc cgtttggtaa atcgggattt gaaacggacg 3107881 gaagagctcc tccagcgtat ttgctgtttt ctcatcggcc gtcccgatca cgatcctgtc 3107941 accatgaaag gtatcataga tcgccgaccc ctcacgcaaa aattccggat tggatgcgac 3108001 cgaaatactg acaggctccg ctagatgttc agtaatcagt ccattaatca aatcgtttgt 3108061 cccaacgggc actgtgcttt tcgttaccac gactgtatct cgtttgacat gctttgcgat 3108121 gcgtttggcc gcatctgtaa tttgctccag attggcgtgc ccgtcgcttt tctgcggtgt 3108181 gccgaccgct ataaaaatga tgtctgcctg tgccaagcct ttctcatagc tcgtttcaaa 3108241 gttcagccgt ccatcagctg tattttttct catcagctct tcaagacctg gttcaaatat 3108301 gggggaaatg ccctttctca tttcatcaat cttgtgagcg tcaatatcaa tgcaggttac 3108361 atgatgtcca atctcagaaa gagaaacacc tgtcacaaga ccgacatagc ctgttccgat 3108421 gactgttata ttcattgttt ccctccaaca gttaaattgc tgctttgcag cttccgtaat 3108481 atcgtatgag aacatcctat catgaatgcg aatgatctcc cgcatagcct gtcgggtaca 3108541 gcctgtacag atttctgaaa tgtgattcaa ccatacaata cactattata tcgctctcaa 3108601 aaagaaagtg gtgaaatgag aatcggctgt taaaaaaaac caaacaattt tcttcttttg 3108661 accggctgcg gaggctgtct gaagatggtc tgattccgca ggagaagctc tgcattttcc 3108721 gtcagcatat aaggaagttc cgagccgaat tctttctcta gaacataaag agcctcttga 3108781 gtgtgaaaat ttctcgtttt cacattatgg gcatctgagg ctacgaaatg gatcaaattg 3108841 gcttcaacca gccggagaga aaatgctttc agctgcttgc cgaagatccc cgcaagactt 3108901 cctgaagtaa tctgagatgc tgctcctttt tccacaagat gatacagcaa ggacgggttt 3108961 tcgcgaattt ccctgttgcg ttcaggatgg gcgataaccg gaatatatcc tttcagctgc 3109021 aaatcataaa aaagctgctc cgcatatcgg ggaacgtgat caaacggaaa ctcaatcaag 3109081 atgtattttg tatcattcag cgaaagcagc tgacgtttgg caaggtcttg ttccacctcg 3109141 ccgtagattc tgatttcctg tcccggaagc acatgtaaag gaatgtcttc tttgattaaa 3109201 cgtttgttta actgatctgc tgcttctctg actgcggctg gctcgttttt atacacaccg 3109261 ttgttatgat gaggtgtcgc aatgatcgtc cggattccct gacgaacagc tgctcttgcc 3109321 atttctatgc tgtcggccga atcacctgcc ccgtcatcca ttgcgggaag aatgtgacag 3109381 tgaatatcga tcatgtccta gccccctttt ttcgcaaaaa taaataacgg gcacgatgca 3109441 cgttatttat ttttgcatga aattgtcctt ggttccgtaa tatccgtatt cagagtgctt 3109501 cgaaagcttt ttgccgttca taatcgcccc aaggagcttg cttttgcacg ttgcaagcgc 3109561 ctctttcgct tttgcggctt gttctttttc tgttttcccg cttgaaataa ccagaacaga 3109621 accgtctgcc acgttgccta aaatctgtgc atctgctacg gcaagaatag gcggcgtatc 3109681 aaaaatgacc atatcatatg ccgcacacgc ttcgtatgca agctccttca tccacttcga 3109741 ggagagaagc tcggccgggt ttggcgggat cgggccgctc gtcagcacgt caagatgttt 3109801 ttcattcgat gcttgtacag cctgctccat agagcttttc tttaataaaa cagatgttaa 3109861 gccaaccgta ttttcaagaa aaaaagccgt atgtactgtt ggttttcgca aatcagcatc 3109921 aatcaggagc actttttttc cctgttgggc gaatacgaca gccaggttgg cggccgttgt 3109981 tgattttcct tcccccggac aagccgatgt aatcatgact gatttcattt gccggtccac 3110041 tgaagcaaat tctatattcg tgcgaatcgt ccgatattgt tcagagttca aggatttcgg 3110101 ctctgtcatt gcaatgacat ttctctgcat ccgcgagcct ctgttttttc taagcgccaa 3110161 aatgtccact ccccgttttt tcagattgga aaccctgtaa ggtctttgct gttttctgct 3110221 cattcgcaat ggtggaaact gtccctaaaa caggtatgtc cagcaaggat tcgagctgct 3110281 cttccgattt gatcgtatta tccaaatgct caagcaggaa ggccagtccg atgcttcccg 3110341 ccaatccggc cgcaaacgcg atggcaatgt ttagtagcgg ctttggcgat acaggggacg 3110401 ggtgttctga aacctcggct tttgacagaa tgctgacatt gtcaacattc ataatggatg 3110461 tgattttgtc ttgaaaaaca gatgctatag tattggcaat atgagccgct gtttccgcgt 3110521 tttcatccct gactgatatg ttgaccactt gggagtcctg ttcgctggat acggtaattt 3110581 tgtcattcag ttcttgggat gtcatcgaca ggcccatttc tttaatgact tcatctaaga 3110641 tggcagggct cttaatgatg acattgtacg tattgattaa ctgaagattg gtttggacat 3110701 cgttaaattg gacttctttt cgttcatttt tcgattggtt gaccagaatc tgagttgaat 3110761 tttcatagat gggtgtaagt gcgaagaaac taatgagtcc gccggcagca gtggcagccg 3110821 cggttacaat cataatcaaa agtatgcgtt ttgttaacgt tgataatatc tcttttaagc 3110881 ttgtagattc tcccatgata cctccaaatc tcttataaca tccttttcca tctacgatta 3110941 tacaacgttg aaaccgcatt tctccagctt ttcacgtgac ataattcgac atttttttac 3111001 aatgcgttat gttagtactt tttatgtaag cgctatattt actgtgttga cagtgctgtc 3111061 tcattttctc ttattcgggc agtcacgttc tctcgcataa aaaaatcccg ctaaaggcgt 3111121 gcgggatttt tatgttgcat atccattttt aatatgagaa atcaaatttt caagcatttc 3111181 cttcgtcgtc atctcagatg actgctcacc aatttcatgt gcatgcatca aaattttcag 3111241 aaattcttct tgattcaatt tcttttcact catctttttt ttcctttcag cttccattaa 3111301 gttgaaaaca cgattattat atgatgctgg ttatcaattt gcaatctcta atacatcatt 3111361 cgacacatcc tattttttat gtcctttttt aggaaaaact ttttaaggcc gatgtgttgc 3111421 gatataatag agaaattgga tctttttatt acgtgactcg gttaggagcg ataatcatgc 3111481 ttcagaatat gatttccaaa gacgatgtgc tggcatctgc tgaacagtta aaagaacttc 3111541 ttccttacaa tgaggaaaat gttcagctga tcaaaaaagc ccttatttta tatcggcagg 3111601 attcagtcta tcgtttacaa gcagtgagtc cgacggaagt tacggcttac gtgcaggatg 3111661 ttgtgcctgt gcgggtcaca ttgaacttgt ttgtcatagt caaaagcggc tgttcatgtc 3111721 cgtccggaag aatctgccgc catatgctgg ctgtgttttt atatgtatat gcaatgttcg 3111781 agcgagtggg tacttttaca gagtattggc tggagaggga aaagcttgag gaaagcaaag 3111841 agctcgtccg ccgccagttt caggaaaagg tgctgcctaa tgaagaatca ctttcaagct 3111901 ggcttgcttt ttttgattca gagttttctc tctggcaggc acgtacgcca gaaggcagcc 3111961 aaaacatgca gggcctctat tacggctacc tgtccgcatt aaaaaaacat gcgccgaaca 3112021 agccggagct gaaaagcctg tatcagattc attccgcgat tgcggtttgg cttcgcatgt 3112081 tcacattgat tgaagcgggc aagctaaacc ccgaacaaga tttttattcc ctcaatccgt 3112141 acgttgaaca gctgatggat acaatctaca gctctattga taaattaaaa acgtacgcgc 3112201 tgtcttttgc gcttgatccg tttttggata aaacaccgga tgttatccgg catttgctgt 3112261 tgaaagaaga aattttccaa tatgaacgca tccgcgtctt cggtgaaatt tggagtgcgc 3112321 tgctgtcgcg gccaaaatgg gtggcacgcg aacaggagat attgaaaaaa gaagcaggac 3112381 ggcgtttttc tcccgaattg caattcgggc gcctgcattt ggaattcctg caaaaaaatg 3112441 atgacgttat ttttgaggaa gcggatcaat tcccgccgga agcgctccct tatacattcc 3112501 aatggctgag tgaaatgact gccaagaagg actggaaacg gcttaaaaca tggtaccagc 3112561 aaattgaacc aattgcgatg ggttatacga agctggataa gccgtttaaa gagattcgcg 3112621 atgtgatcgg cgagctgttc cttctgttga atgcctatgt gcagcaaacc aatgatcaag 3112681 cgctgtttga gcgctttgcc gcgggctgtc tgccgtatac gttcacagaa tacagccatc 3112741 atttatatga aaaaaaacgc tatgccgagt ggattgaaat tcatagcctt gtcggctttt 3112801 ccatcaatga aatggataaa atgatgctca aggaaattgc agcgagcgac cctgaggcgc 3112861 ttataccggc ttaccataga gaagtggctt ttttcattga tcagaagaac cgtagctcgt 3112921 acaaggaagc cgcccggtat ttgaaaaaat tgcgcaccct gtacaaaaaa gcgaaaaagc 3112981 agaaggtgtg ggagcggtat attcagctgc tgagctcgca ttacaagcgc ctgcgtgcgc 3113041 ttcaagaaga actgcagaaa ggaaagttga ttgatggcga gtcttaaaga aattctcatc 3113101 cacgtcgaac aaatggaaga tgggtcattt acgctctcag cctttgatga gaatgagcag 3113161 cctcttccct acagccatat gaaaaagcat ttgttccaat ggcatgaatc ctcattttac 3113221 ggaacctttc tagaggatgt cagcttcatc gggacgactg ctgtccttct atctccatgg 3113281 atgactgtag agcttctcgg caaaaactcg ttcaactcat tcagctccgt gcagcttaca 3113341 gaagaaacgg agccgctgat cgaggcggca tcgaccatct atgaatttat cgcggacggc 3113401 gattttatgc ctgactatga cgcatggaca aacggtgttt ttcgctggaa ggaccgcgat 3113461 aatatactgg aaggctttac tgcggaatgg ttttccgctg ccgtacagga ttacatccag 3113521 tacgacgatg acctgcggga gaaatgggaa catatcaagg aaaaatcgcc tgcggttacg 3113581 acattccgtg gccattttct tgatgaagag gattttctgg aaggcattgg ctggattgac 3113641 gatcaatctc catttactgt cggcttgcgc ttaaatgaac cggactttga cggagacgaa 3113701 tggaagatcg agatgttttt acgcgataaa aagagcggtg ctgtagaatt ctttgacgga 3113761 ctgaagagcc tcaaaaaatc gtggcaggcg tacagcgata aaatcgcgcg tgagcaggac 3113821 cgctttcaca gaacggttcc gtggctgtcg tttgattccg ggacaacgct gatctcggag 3113881 gaagaagcct ggatcttcct gtcagaagca agtgagacgc ttgtcgatat gggggtagaa 3113941 atcctcctgc cgtcctggtg gcagattgtc agagacagca acatgatgct gaaagcaaag 3114001 gtgtcttcct ccccgcgcgg cgagtcattt gtcggcatga atgcactgct tgatttcaac 3114061 tggcggtttg cgacaaatgg aattgaactg actgaggctg aatttaatga gcttgtcgcc 3114121 agcaacaggc gccttgttaa tatccgcggg caatgggtta aaatcgatcc gcagtttatc 3114181 aaacagatga aacgcctgat ggaaaaagca gaatcagagg gactccacat gtctgatatt 3114241 ctggcgcggg agctaatgga tcagcaggat ggcggacttg aggattcgga cctgattgat 3114301 acatctgctt ttgccggcat tcagtttgat ctgtctaaac agctcaggtc actgattcga 3114361 aagctcactg ccgcggaaaa cctgccggag cacaaagtca gtccttcttt caaaggaacg 3114421 ctccgccctt atcagaaata cggcatgaac tggctgctgt ttctgcggga aagcggtttt 3114481 ggcgcctgtc tggctgacga tatggggctt gggaaaacga ttcaaatgat cgcctatttc 3114541 cttcacgtga aggaaagcgg ccgacaaaaa acgcctcatt tgattattgc gccgacatcc 3114601 gtacttggca actggcagcg ggagcttcaa acctttgccc ctgatctgtc tgtcgcgctc 3114661 cattatgggc cgcgccggcc aaagggtgat gatttcgccg cgcattatga aaacgcagac 3114721 gtggtgctca cttcatacgg tctgtcacat gccgatactg aagagctttc ttctgtgaca 3114781 tggaacacga tctgccttga tgaagcgcaa aatattaaaa acgcgcatac gaagcaatca 3114841 cgcgcaatca ggaagctgaa ggggcttcac catatcgcgc tgagcggcac gccgatggaa 3114901 aaccgactga ctgagctgtg gtctattttt gacttcatga ataaaggcta cctcggcagt 3114961 ttgaccggct tccataaacg ctatgtgctg ccgatcgaaa aagaccggga cgaaaagaga 3115021 atcggacagc ttcagcaatt aatccggcca ttccttctcc gccggacgaa acgggatgaa 3115081 gaggtcgcgc ttaatcttcc tgagaagctg gaagaaaaag aatttatccc tctgtcagcc 3115141 gagcaggcat ccctttatga gcagctcgtc aaagacactt ttgaccatat gacatccctg 3115201 accggcatgc agcgaaaagc gctgatcctc agcatgcttg gacggctcaa gcaaatatgc 3115261 gatcatcccg cgctttattt aaaggaagag caaaccgagc tgctggccgg cagatcagtc 3115321 aagctcgaaa aattgctgga actgatgaca gcgatccgcg cccaaaacga aagctgcctg 3115381 attttcacgc aatacattca gatggggaac atgatgaagc ggctgcttga aaaaacgttc 3115441 ggggaacctg tgcaattttt aaatgggagt ctctccaagc aagagcggga tacactcgtt 3115501 gagaaatttc aaaggaaaga atatccgaca ctgattcttt cactcaaagc tggaggcacc 3115561 ggacttaatt tgaccgccgc caatcacgtc atccattatg acagatggtg gaacccggcg 3115621 gttgaaaatc aagcgactga ccgtgcatac cgcataggcc aggagcgctt tgtccacgtt 3115681 cataaaatga ttacgacagg aacaatcgaa gaaaaaattg atgtcatgct tgaatccaag 3115741 caaaccctga acgatcaaat tatccaaagt gaaaactgga ttaccgagct ttccacacag 3115801 gagctcgaag aattgtttac attaagcgct acagcgcaat aatcatgact aaaaaagctg 3115861 gctctaaaag agccagcttt tttccgttca tagccgtcac gccgaatttc caaaaaatcc 3115921 gttacgccgg ttatcaacag ggtgcgcttt tgtggcagca catatactta caacaaatgt 3115981 ttcatcatat gtgcgacacc gtgttcgtca ttggttaagg tgacagcatc ggctatcgat 3116041 ttgatgtctt cccgggcatt gcccatcgct acaccttttc ccgcagcctc cagcatcgat 3116101 ttgtcattta aactgtcacc tacagcagca gtttcctcga gcggaatatt cagctgtttt 3116161 gcaagcctct tcagcgcctg ccccttggaa gctttgcggg aagaaagctc aaagttgtgc 3116221 tcagccgaac tgacaagcgt caaatcttcg gcatgctcat atcttttcca gcctgcctca 3116281 agcttttctt tgaagaaaga aaagccgaga atattgtaaa aatcgattgg ctcatcggct 3116341 tcaaacagct cttgaaagga gttaatgtaa gcaaagcccg attggctgta ttgcacctcg 3116401 gccgcctgct taaggacaga aagatccgct tccggatttg cgcttctgaa tctgtcgagc 3116461 tcaacatcaa gaagttctct gccgttttgc ggcgtataaa tcgctgaacc tgtgaatacc 3116521 tcataataat agttttccga ctcaagccat gagagaatgt catacgcccg tttcttatca 3116581 atcgtttcgt gatgataaag cctgccctcg ggatcgtgaa tgacggcgcc gtttgcactg 3116641 atgacccatg ttttgatccc cagcggttca aagattgaca tgacgtcaaa atgagcgcgc 3116701 ccagttgaca ccaccacttc aatgccgtcc cgctgcgcct gccgcagtgc gttttcattt 3116761 tccaagctta cctgatgctt gctgttgagt aaggttccat ctaagtcaat cgcaattaat 3116821 ttcacgtttg tcagtccttt ccttcatcct gctctgtcac gagaagctca acgccgtttc 3116881 ggtcaagcaa gtcacaaaat gcctgattcg gcagcctgtc tgtaatcaag aggtcgattt 3116941 cattcagctc cgcatactga taaaaactgg tgctgcccag cttagaatgg tctgcaagcg 3117001 caattacctg ctttgcctgc tgtatcattt tccgcttcac catgccatcc tcttcatgcg 3117061 caattgtaat gccatgttcg gaaatgccga ccacaccaat cagcgcttta tcaacatggt 3117121 agcttgagag cttttcaatc acagaggacc cgtacagaaa gcggtgctcc ttttccagct 3117181 tgcctcccag cagataaatt tcaattccct ctttatcgga cagcacatcc gcaagattaa 3117241 tcgaattggt gattacggta caatcaaccg cattcaaatg ctttgcacat gcctgaacag 3117301 ttgtagaggc gtctaaaatc acccggtctc catcatgaat aagcgatgct gcaagcctgc 3117361 cgatcttatt tttttcctca gacactgttt tcaggcggcc ggaatagctt tgaattttct 3117421 gatgcacagt cggtaaaatg gcgccgcctc ttgtgcggat gatggcattc tgttcctcaa 3117481 gtttcacaag atctcgtcgc gctgtatccc ttgacacttg caggagcgta cagatctgct 3117541 ccgttgtaat tcggttatgc tgttttaaaa aatccaaaat cgctactaat ctttcttctt 3117601 ggtacacgcc ctcattcctt ttctcagcaa tcatttataa gtaattataa gtttttattt 3117661 gattttattc aacattaata agtgatttta agtaaaaatg cgtcgagaga accaattttt 3117721 cctaagtagg caaaaagaaa gaaccagtct ggtcgactgg tcaattttga ggggatgatg 3117781 cgaagatccg gataatagtg aatggataga taacgggagg agcaggggtg tcaatcagca 3117841 gctttttccc ggggtttagg gtccataaaa cgaacagtgt cagccaacac ttctgttaca 3117901 tacacgttaa cgccttcctc gttttcatag cttcttgtct gaatccgtcc gcttacgccg 3117961 acgagagaac ctttttggca atacaacgcc gtgttttcag ctgtttttct ccaaagtgtg 3118021 caattgacgt aatcagcttc gatttcacct gaagcattct tgaagctgcg gttcaccgcg 3118081 agcgtaacat gtgcaactgc cgcaccggcg gaagtgtagc gaagatcagg atcttttgta 3118141 agacgtccga caagcatgac ctgattgaac atgcgattcc tcctctcctt gcggttgtat 3118201 gtattgtaaa tgatgcaaca agaaaagaaa aacgcttaaa aatggctttc agcctctgtt 3118261 tttatctttc gttttcattt ttccttcagc taaaaacatc ttttgctttt ttcctttgaa 3118321 gaaatatgta ctttttaaaa aacggaaaaa gatttgcttt gtcagccagt tttgcgtatt 3118381 catgcgcaca taggaagagc catcccacgc aaaccactga aagctcaatt ttttttccgg 3118441 cattgacagc ttgattttat actgctccat gccatcttgt gtttcgtata aaaaacttat 3118501 tcttcctttt ttgttcagat gaacctcaaa cacttcttta cggcttaaca tatatgttac 3118561 ttccttttga atcaaatgac tttcagaagg aacgccgtca atataaattt cttttaaacg 3118621 aaattgattc ataccacatc tctccgtaat ccatagtcag ttacagtata atgaaaaaat 3118681 agaaattatt aaatgtttcg ctcatacaaa attctttagc cccaacattg caggattttt 3118741 tcctcgaaaa cgtttatgtt ataatggaag gcaagaaaac tttggaagta atcggggtga 3118801 gaagaaatga aaacctttaa actggttgac ctgaatgtgg aacgagtgga caaggaagaa 3118861 caatcaattg aacagtttcc ccttattgac ggactgatta taaataaaga agacggtgaa 3118921 aatcactggc tgattgaggc gcttgtacag aaagaacatc tgtctttttt tgaacagctt 3118981 caaaacagcc aatctgaagc caaagtattt gtaacgatca cgaaaaaaag caatcgcccc 3119041 gcccagctga cagcagcagt gaaaaatatc gtcaagctgg aagaaagcat tcaggtttta 3119101 ctctacggac aaatggtcac aagaaaacag cagggcactg aaaccattct cgagtccctt 3119161 gtaaaagagg gctatacagg aacaaaactc attgaggcat ttaagcaaaa attataaata 3119221 tgagggggca tgttccccaa aacagactca gaaccgaaga gcatcacaat agacatttag 3119281 aatagatatg ttctgcatga aaaaagctgc cgttttgaac ggcagctttt ctcttcgtgc 3119341 tttcactctt gcatatttaa tttgtatggc caaaagaatc aaccaattcc cctttcacaa 3119401 cgaggcgccc ttcggttttg accgccttgt cacatgtgat taacgtaatc tcctttttgt 3119461 ttgtctcctc aactacatct gcatccattt ccgatatgat gtctttcgat gttacagaat 3119521 agatataatc ctttttaaaa tccgtgatga caatttgggc acctgttttt atgttttcca 3119581 gaggtccgaa cagaagattc ttttgcttca aatgatggcc cgccaacgga taatttccct 3119641 cacccatttt ttgatcccgg cgcattgttg ccgcccctat caaaagattt tcattggttg 3119701 tgccttttac gatcggaagc tccagatcga cacttttaat tgttatccgc cgccttgatt 3119761 gtgaagtaaa aataagtata tttcacgtgc tttcgacgtt ctccacttga ctggaatgct 3119821 ttaatggcga tcccggcatc tgtagcttca ggctttcctt cagaggaatc agaaatctca 3119881 aactctattt tctcagtgtt cagcacataa ccggctggcg ctttcgtttc aacaaaagcg 3119941 tattgtcccg gtgcaaggcc tgaagctgtg acttgatgat gccggatatg actggtttcg 3120001 aagtctgtat gaaaattcgc gaacgattca gcatggttga tcttccggtt ctgatcatta 3120061 cagctgccat tatcggccat gacaaataca aggcttttca tgccggagcg aatgacattt 3120121 tgcaaaaacc ctatcattac tctgaattta tggcgcgtat tcaaaacctg ataatgatga 3120181 aacatacagc aaatcaagcc acaagaatgg aaatggcgtt tctccagtcg caaatcaagc 3120241 ctcattttct ttataatgta ttaaacacga ttatttctct cactcatttg gatattgaaa 3120301 aggcccggga ggtaacagag gaatttacca actatttaag aatgagtttt gactttcaaa 3120361 atacatcagc catcagttcc ttcagacatg agctttcgat tatcaattcc tatctttcta 3120421 tagaaaagac gcgattcagt aatcggcttg aggttctttt cgatatagat gaagacattg 3120481 actttatcct tccgccttta atgattcagc ccttggtgga aaatgccgtt cttcacggtg 3120541 tcagcaagaa aagaggcgga ggatggatca aactgacagc taaaaaacaa agcaaaaatg 3120601 agtatcacat caaagtagag gataacggtc ccgggataac tccggaaaaa caaatagatc 3120661 tcttatcaac ggattttgat cgcagcgtcg gattgaaaaa tatcaatcag cggctgaaac 3120721 atttttgcgg aagcgagttg atgatcagca gcactccgga tgcaggcacc tctgtctcaa 3120781 tgctcattca tctcgctgaa acaacaggaa gccctaaaga actgaaggac acagaacgaa 3120841 cctaaacgaa aattgagata aaaaaagacg ccgtttctaa cggcatcttt tttattccgg 3120901 cgactttgct tgctgcttca gcaggtctct gatttctttc agcagctcct cctgcgcatc 3120961 caccgcttcc tccgcagcct cttcttctgc ttcttttttg cgccttaacc cattcaaagt 3121021 ccgaatgacg ataaaaatgg agaacgatat aattaagaag ttcacaatcg tctgtataaa 3121081 gctgccatat ttcactacag catcgccaaa cgtaaacgac aggcctgaaa agtcaagccc 3121141 tcccagcagc aaaccgacca aaggcataat gatatcattt actagagatg tgacgatctt 3121201 tccgaaagcg ccgcctatca caacaccaat cgcaaggtct acgatattcc cccgcatggc 3121261 aaaggcttta aattcattcc acatacaatc acctgctttt ctatatttgt aaagaaaaaa 3121321 agacaaatgt gccgctggcc atctgccttt tttcaattat tctccgaggg caaaagtcag 3121381 ttctacttcg caaacgactt cgccatcaac tgtggcaacg ccttttccgc gcccgattgt 3121441 gccgcgggca cgaatgattt caacctcaag gtgaagctgg tcaccaggct tgacttgttt 3121501 tttaaagcgg cagttatcaa tgcctgcaaa aaaagccagt ctgccgcggt tttcttcttt 3121561 aatcaacatc gcaacagctc cgacttgagc gagtgcttct acgattaata cgccgggcat 3121621 aaccgggtac tgaggaaaat gtccgttaaa gaactcttca ttagcggtta catttttata 3121681 gccttttgcc cgtttgccct cttcaacttc cgtaatccga tccacaagca aaaacggata 3121741 acggtgagga ataatttctt taatttgctg agtatcaagc attgtcttga catctccttc 3121801 atctgcatta gtatgtatag caatcatcaa agatccaatc tgtacatttg aaaagtatat 3121861 tatgaattaa tctctttttc aaccgcgcta aaatgtaacc aactgtcaat gagagccgtc 3121921 aaaagttatg atatgataat tatagatttt accaatagca aagaggtagg aaaatgattt 3121981 cgaagtttat tgaaaaaaga atgctaaaca tgttagacga gtggtattcc gcaatgagca 3122041 aacgcaaaat gaatcacgtt tgcacactga aagagaaaat tgatcagcac cttccaaaga 3122101 tcaaaaagaa cacaaaactt tggatgcgtt atcaattgtt tcaggcccgc catcagctgc 3122161 tttttgaaaa ccagaacgga ctcgattcat tgttcgatgg cctatatggc ctggaagaca 3122221 aaatggatga tgaattgaaa tattatctgt attttttctc tgggttatat gagatggtaa 3122281 aaacagctcc gaaacatgca gtacatcatt ttaaaaaagc tgaacagtac ctggccgcca 3122341 ttcacaatac gtttgaagcc gctgatttat attatcaaac cgccggcgcc tattacttga 3122401 tgaaatcacc gccgctttcc gtccaatacg tcaaaaaagc attacacatc tatttgcacc 3122461 aattcggcta tatcaaaaag gtaatcacct gtaaactttt gctcgccgtg aattatattg 3122521 atcaagaacg ctatgaaaaa gctgaacagc ttttcaaaga aatcattaag aaaacccagc 3122581 aactacatga cgaaaacctg ctatgccacg cttattataa ccttggcttt ttaaaagcga 3122641 ccgagaaaaa agaccaggaa gcgcttcttt actttagaaa agtattaaag aatcaagaat 3122701 ttgaaatgaa ttcaccagtc tcatatcttc attgtgtgta cgagtctgtc agagcgcttt 3122761 ttaaaacagg gaacatcaca gaagctaaag ccgtccttca aaaaggaaaa gaattatctg 3122821 aaaaggtaga cattcaaacc atttatttaa aattaaaaac gcttgaagcc ctctacacat 3122881 cagccgaaga cccttatgag cagctgctcg aatatgtgct tgaattagaa aaaatcgagg 3122941 cgtgggtgga tttagaagtg ctgttagaag atattacgga atactacaaa aaaaaggacg 3123001 atttcgaaaa agccgctttt tttatcatgc gcggctgatt gaaaaacgcc cattttctta 3123061 ttatctgact gaattgatta aaccgagcat ttgatctccc attgtgatcg ttctgctgtt 3123121 cagctgatat gaacgctggg acgtgatcaa atctgtcatt tgttctgaaa tatcgacatt 3123181 ggacatctca agtgagccct gctgcatgcc gatgttttgt ctattagcgc cgttcagctc 3123241 ttcaaaagct gccgcattat caatagagaa aaggttattc ccttcggatt tcagctcttg 3123301 agggttattc acttggacaa cgccaagatt aaaccgctga accgcgtttc cgtcagatgc 3123361 ggttaaggtg ccgttcttat taatggtgat attcttcatt gagctgtcga tgttcactgt 3123421 attgccgttc tcatcaagta cgggataccc atttccagtg acgagctgca gctggttggc 3123481 attcgcagcg gacggcgtta catacagcgc cccgtccctc gtatactggc ggtttccatt 3123541 tacatttacc tgaagatact ggtatggaga cgtaaatgcg atatccagat cgcgatcggt 3123601 cttctgaatg cttccttgat cagagactag gcgtgaactc atcatcgctc cgacgccaag 3123661 gcgcaagccg ggcggcgttt ttcgggcttt tgccacttcc tcgttttttt catcaacctg 3123721 atcgaattgc tgtctgacaa gctcagaaaa attcgtatct tttgccttat agccggttgt 3123781 gttgctgttt gaaaggttgc tgctgattgt gtcaatctgc tgctgcagct ggtttaaggt 3123841 tgttgatgcc gttagcattg acctgagcat agttgatgtc ccccgttttt ttcttccgtt 3123901 ttcttaaatt tttccaattt catttgctgc tttatccata cttttatcgt aagcctgaat 3123961 aaccttctga ttcgcctcaa acgatctgta cgcttcagtc atttctgtat aggcgcttgt 3124021 cacatccacg tttgaaagct ctgagacgcc ttgttttaat gaataggcta cctgattatt 3124081 tccggctgcg cttggcagat cattaccgtc cgccgtgctg tacaaatcat ttccgtcccg 3124141 tttgagattg cggacatctt ccgccattct gacatcaatc tggccggctg tgcgtccgtt 3124201 cgttgtcaca gtaccgtttt cagacacagt gaaattctca ttatcaacag tgattggctg 3124261 gcgatccgtc gataaaatag ggcgtccgtt gatcgtcagc tgattgttct catttagtga 3124321 aaatgtgctg ctttttgaat aacggattcc atccgctgtt tgaaccggat aaaaaagagc 3124381 agctttttca ttggtttccg cactcatcgg aacttgattt tcgatcaatg caatgtctgt 3124441 aggctggtct gtggacttca ggcttccctg tgtaaagaga ggcttgagct cctgcatata 3124501 tactccggta ttcacggaac cgatttccgt ccttgatgtc ccggccggag attttgattc 3124561 tattctgctg agcagcatct cagggaacgc gcgcatagag ccttgatcag ctttatatcc 3124621 tgatgtattt gcgttagcaa tattatttga aagcatttcc gttcttcgct gctgggcaat 3124681 cattgcggat gttgctgtat ataatccttt taacaaattt cccacctcta aaaatggcat 3124741 tttttccagt tgtcatatag gaacgttcgt tctataataa aaactcagta ttttatccta 3124801 ttatcgtcat ttaacatctt ttcgtgaagg ctttttcata aaaaaacctc attctttttc 3124861 agaatgaggt ttgtgaaatc agcttagttt gcgtttagga agcttgtcca tattatcaag 3124921 catgacacct gtgccgatgg ctacgcaatc cataggattt tcagcaacga ggaccggtac 3124981 cttcagctct tcagcaagca gctggtcaag gccgtttaag agcgcgcctc cgccggtaat 3125041 aataacgccg cggtcaataa tatcagcaga aagttcaggc ggtgttcttt cgagcacttg 3125101 ttttgcagcc tgaacaataa cagcgacaga ttcacgaagg gcttcttcaa cttctttact 3125161 gtttactgta attgttcttg gaagaccgga aaccatgtcc cgtccgcgaa tggaaatttc 3125221 ctcgtgacgt gcgtctggga aaacagttgc gactttaatc ttaatatcct ccgcagtacg 3125281 ttcgccgatc agcagcttgt actcgcgttt gatataattt aagatttcca tgtcaaactt 3125341 gtccccagcc attttaatag aagaggaggt gacaatatcg cccattgaaa taaccgcgat 3125401 atccgtcgtc ccgcctccga tgtctacaac catgttaccg cttggctgga atatttccat 3125461 acccgcgccg atagcggcaa ctttaggttc ttcttcaagg tacacatgtt tcccgccgct 3125521 tttttctgca gcttctttaa ttgctttttg ctcaacggat gtaatattcg tcgggcagca 3125581 aatgagcatg cgcggctttg agaacaggcc ttttacattc agcttgttaa taaaatgttt 3125641 cagcattgct tctgttactt caaagtcagc aataactccg tctttcagcg ggcgaatcgc 3125701 aacaatattc ccaggtgtac gtccaaccat tcgtcttgcc tcttcgccaa ccgccagcac 3125761 tttgccgctg tttttatcaa gtgcaacaac ggaaggttca ttcagaacaa ttcctttacc 3125821 tttaacatgg atcagtacat ttgcagtacc gaggtcaata ccaatatccc ttgcaaacat 3125881 ctatttatat cctccttgaa aatctgtttc acagtaaata tccacattgt gccctaatta 3125941 tatatattat cataaaatat agaaaaaaag ttggaagcac aataagttct ttacaaattt 3126001 ttgcggatgt tttatgaacg atttcaagaa ggcaatgcca ggtgattacg attgctgaac 3126061 aggctctcct tcgagaattt catctttttt atatttgagc tttgtcgctt ctcctcctct 3126121 taaatgcctg atggatttat gataatcgag tatttctttc acttcgtttg ccaagtcggg 3126181 gttaatttca ggcagacgct ctgttaaatc cttgtgtact gtacttttgg aaacaccaaa 3126241 ttccttcgca atgacacgaa cggttttctt tgtctccacg atgtacttcc ctatcttgat 3126301 tgttcgctct ttgatgtaat cgtgcacacc actcgacctc cctaaaatgg atgtgagaag 3126361 tgtgaaatga gatccgtatt ctgtaaagag tcgttcatta tgccgcttct tcgttgtatg 3126421 gttttaaaag taagtttgtg aaatatgccc acgatccctc acctcaaaca ctctctttgt 3126481 taggtttgta acagtgtatt agcattcttt tgggaatatg ctaaaaactc aataaggaca 3126541 aggggtgaaa cgaacttttt cagattcagc aaactatttc gcgtcactaa attttcatct 3126601 ttacaactat tgatcgctcc tgtaaaatga aataagcaat tagttactta ggtaagtttt 3126661 ttagaaggag accgacatgt cctacgtcaa cagacacctc attcatcaaa tcaaccaaag 3126721 cgcccgcctg attgccaaga aagccaatga acagctagag ccattcggcc tttattcatc 3126781 tcaatggtca gttttatatt gtttgcgtac gatcggacca atgactcaaa aagagatttg 3126841 gtcctattta aatgtggaag cgccgactgt gactcggacg atcaaacgcc tggaggagaa 3126901 cggctgggtt cagagacggc aaggtgaaga caaacgggaa aaacttgttg tcctcacaaa 3126961 agaagccgag aaaaaatacg aagaaatcaa tgtgaaaatg ttgaaattcg aggaagagct 3127021 gcttgcagat ttccgggatg aagataaaga agctttttct catttattcc gcatgttttt 3127081 acaacaatga aaataaggaa gtgacataca tttgaaaaaa gcggatgcga tatggaccaa 3127141 ggattttatt atggtcctgc ttgtcaattt atttgtgttt gtgttctttt atacattttt 3127201 aactgtattg ccgatctata cactgcaaga gcttggcggc acagaatcac aaggcgggct 3127261 tttaatcagc ctgttccttc tgtctgcgat cattacacgg cctttctccg gagccatcgt 3127321 tgagcgtttc gggaagaaaa gaatggcgat tgtatcaatg gcgctcttcg ccctatcatc 3127381 ttttctgtat atgccgattc ataacttttc cctgctgctc ggattgcggt tcttccaagg 3127441 gatttggttc agcattttaa cgactgttac aggtgcaatt gccgctgata ttattccagc 3127501 caaacggcgc ggtgaagggc ttggatactt tgccatgtct atgaacctcg ctatggcgat 3127561 cgggcctttc cttggcctga atttgatgag agtggtaagc tttcctgtat tctttacagc 3127621 ctttgcgctg tttatggttg cgggcttact tgtttcgttc ttgataaaag tgccgcaaag 3127681 taaggacagc ggcacgactg tattccgttt tgcgttctcg gatatgtttg aaaagggcgc 3127741 actcaaaatt gcgacggtcg gtttgtttat ttctttctgt tattcaacag tcacatcata 3127801 tctgtctgta ttcgccaaat cagttgacct ttcggatatc agcggatatt tctttgtttg 3127861 ttttgcggtg acaatgatga ttgcacgccc gttcacaggg aaattgttcg acaaagtcgg 3127921 accgggcatt gtcatttatc catcaatcct gattttctct gtcggactct gcatgctgtc 3127981 cttcacacat agcggcttaa tgcttctgct ttcaggggcg gttatcggtc ttggctacgg 3128041 atcaatcgtt ccttgcatgc aaacattggc gattcagaaa tctccggctc accgctccgg 3128101 ttttgcgacg gcaacgttct ttaccttctt tgacagcgga attgctgtag gatcgtatgt 3128161 attcggattg tttgtagcat ctgccggctt ctctgccatt tatttaacag cggggctgtt 3128221 cgttttaatt gctctgcttc tctacacgtg gagccagaaa aaacctgcag aggctgaagg 3128281 aaaagtgtct attgcagaat aacttgtcag actgccggga aatcccggca gtcttttttc 3128341 cattaaaaca cggcgccctc tcggttgaac gagagaacgc cgcttatagc aattattcaa 3128401 tgacaggccg cgcaggtgaa tcaggatcta acgaaaaatc ataggacgct tcatcacgaa 3128461 acatcggatc ggcatatatg gattgttgat cgttttttgt tgcttttcga tacgaagaaa 3128521 atgaatcata ttctttcttt ttccacatcc atatgccgtc ttgatccgct tccttgtggt 3128581 acacgttatg attgaccgta ttaccttcgt tttctgtaaa gtcgtttccg ataaataatc 3128641 tggaatcacc ggccgtcaat atattctttt caattgtgtt gtttttcgta tcgtactgca 3128701 gcagcagctg tccgccgtac agtccctttg tgtcattccg gtacataata ttgcgggcaa 3128761 tcagagaatt gctggtgccg ccccgctttt tgtcatatcc tccgattgaa ataccggtgt 3128821 acgcattgtt gtacactttg ttgtctgtga tctgaatggc atttgcatac tttcctttgt 3128881 gttcagacgt tgcttcaatc ccaatatcgt tatcgtaaac tgtgttgttc ttaatttcga 3128941 tatcgtgtcc tccatcgaca taaatcccgc ccgctgagta ttcatctcca taagcaggat 3129001 tgccgtaagt cgagttttga taaactgtat tgttttctac gactccgttt cgcacgtaat 3129061 cgtttttatc cgcggttccc tcataaccaa ttagatcaat cccgatgtta ttattgttgc 3129121 ggaccacatt gcctgcaact gtgaagccgt cgatattacc gttcagcaca actgcttcac 3129181 tcgctccaag cgtcagtttc tcaactgtat tgtcctcgat tcggatgtct ttcatgctgc 3129241 cagtcccata aactgcgatt ccgtgagcat ttccttcatc cgctgttgtc ttaatccccc 3129301 ggatgtgatt atccttaatg gcgatatgac tgctggaccc tgatacataa atccctatag 3129361 cagttgcttc ctcagatgaa acagaaagat cttgaattgt taaaccgctg atggcaatgt 3129421 catgtttatc gtgaatacga ataagcggtg tttcatattc agcgttcgca acggattcac 3129481 cgctaatcac gacgttttca ttttcatagt ttcggaatgt gataggcttt ccgtccgtac 3129541 cgctgtgctt tacatcaagg gtctcatgat acgtgccctc ccgaatcatg acagttgtgc 3129601 cggcagcagc cttctcagat gcgtgtgcca atgtacgaaa cggcttttct tttgttcctt 3129661 cattttgatc actgccattt ggcgaaacat acagataatc cccagatcct tcctcattcg 3129721 cttttgtctt atcataaacg aaagcgagga tgacagacgt taaaacaccc gccaaaagaa 3129781 taaaatacca ttttctcatt ttcgattccc atttcgtttt agaatagatt tctaaaacca 3129841 ttataaatgt tctatttatg gaaaaccatt tcaaaaatat gaaaatatac cgtctaaata 3129901 gatcttattc agcctggcgg acctgcgcat gttcaactgt ttcaattgcc aatgatgcag 3129961 gcgggtgaac acgcatcaga acaatgtaga aaagaaagga aatcagcaca cctacaaacc 3130021 aagaaatatc gtataagctc ttcaatacag gaacatacat gccaatcagc gaaatcagcg 3130081 ctcctaacat tgtggctgca aacgcacggt aattgtagcc cttccaatac acataccgtc 3130141 ctgtttcgga atacaggtca tctaccgaga gctcacgttt gcgaatgata aaatagtcgg 3130201 ccatcatcac gcctgccacc ggtccaagca tgccgcctat taagccaaga aacgcataca 3130261 cgcttgtcgc gctctccatc agcttccacg gaaccgtaaa taaagcgagc aacgctgtga 3130321 taaagctgcc acgtttgaaa ttgatatatt tcggcagggc attcgctata tcataagcgg 3130381 gtgatacgat attcgccgcg acatttacag agatcgtggc gatgcagagt gtgatcacgg 3130441 acaagacgat gacataaggg ttatcaaacc gcgccaaaat atcgacaaca tcccaaatcg 3130501 gctctccgaa cgcgacctgc gagccggagg tcaccgtaat acttgcgaat gcgaacagcg 3130561 caaacgttcc cggcaaaccg taaaattgtc ctttgatttg ctctttttgt gtttcagcaa 3130621 accgtgtaaa atcaggtata tttaagatca atgtcgccca gatgccgatg atgccagtaa 3130681 ctccggcagc aaacggccag aatgtttctg aaaacgtatg aaactttcct ggttgagagt 3130741 atatcgggcc caatcctcca gcaatatcaa cggcccacca taccatgccg ccaaatacca 3130801 gatacactaa aggccctgcc cacacctcaa aacgtttaat cgactccatg ccgtgatgca 3130861 atacgagtaa atgaatggcc caaaagaata caaaggaaag caaaccggac aagtgaatgc 3130921 cgagaatgtt ccactcgccg ccaatttctc cccaacctgg ccacatattc aaaagcaaaa 3130981 tgttcagtgc cgtgctaccc gcaaaggtct ggatgccaag ccacatgata gctgtaaacg 3131041 cccttagaag cgcggggata ttcgcgccgt atatcccgta agaagcccga atgatcactg 3131101 gaaacggcag cccgtatttt gtccccgcat ggccgtttaa ggcaagagcg ccaaatagga 3131161 taagtgatgc cgtaataatg atcgccagca cctgccaagg cgaaaggccg atcgcaatta 3131221 atcctcccac ggtcgcgtag gtcggtatgt tatgtataca tcccatccaa atggaggcaa 3131281 agttcattgc tttccacgtc cgtttttcct gtcccaaagg caccagatct tcattgctca 3131341 gcctgttgga ttgctgctga ctctctttta atttcatagc cggctcccct ttccatattg 3131401 tctatatgtc gtcacacgtt atgttttttg acattagatg tcacttaata taactgaaga 3131461 gtcagacaat aacactggct atgatataca attttcccgt ttgtatttga acagcttaaa 3131521 caagaaaaag agacagacct cagagcccgt ctctttctta agatgcagtt ttcattaatg 3131581 cagcaaatct cacagccatt aacaggcttg ctccgcccgc tataatcata atgattccca 3131641 tcatatcaaa atgggctgcc gtgatttctt taccaaaaag aatgccaagg atcaccgaag 3131701 acaaaatcga tcctaggtaa cggcaggttt gaaacaggcc tgaagtcgtt cctaccatgt 3131761 tggaaggact cgtttccagc atcgctgcct gaagcgcgac attgcccagt ccgtagccta 3131821 tacccaagag cgacagaatg aggcctttac cgatggtctg gacattgata aaaaagatgg 3131881 ttaagagcac ggctccagcc gtcatcaaaa gcgctcccgc aaagatcggc ttgacgacac 3131941 cagatcggtc gatccatttg ccggttagag gtgacacaac gatgctcatt ccagacataa 3132001 acagcataaa caggccgctc gtttgaacag aaagatgcat ttcatcctga aagtaacttg 3132061 gcaaaccaaa aaataaacaa tagaagaaaa cattcaataa aataaactga acatacacgg 3132121 ctgacaggtt tcgctgtgtt ttaaacagac ggacatcaat aaacggctta tccgttttca 3132181 gctcgcgcca gacaaacgca cagagcagaa gcaagccaag cacaccttca accgcatgcg 3132241 gcgacgtgct gaacgacagc aaaaaggata gaaggaaaat gattcccccg gcaaataaaa 3132301 caattccaag aatatcgagc tgccgaataa tggttttgat tcctgcccct tttttctgat 3132361 ctttcgggaa catatacagg cccaataaga agctgaggat aataaacggc aaattaacga 3132421 taaagatcgc cggccagcct ccccatacaa tcaaaaaccc gccggctgtc ggccccagcg 3132481 ccgtcatggc ggacgcaaaa atagagagta cagccaaggc tgaagcttgg cgctcatgaa 3132541 tatgattccg aatcaagccg acacctgacg gataaatcgc actgctcccc accgattgaa 3132601 acagccgcat gaccaataat gtcataaacg tcggcgcaaa cggcgccccg atggcagaaa 3132661 ccgcaacaag aataagcccg aataaaaaca agcgtttccg cccaatcaaa tcaccgagct 3132721 ttcccgttac gggctgcgct acggcactcg ccaagtaaaa cgaggaaatc agccaggaaa 3132781 ccgttgtaaa cgagaggtga aactcatgct ggatgctatg gagcgcaaga gagatcatag 3132841 acgagttcag cggattcagc attgttcccg aagccacagc tgttaaaaaa acagctcggc 3132901 tttttttcga taacatcatt tcacttgttc cagaaactct tccgttgtcc gcgatttacc 3132961 gattctcggg aaaataaagc gcagtgtggc ttcatgctct tcatcgctaa atgtggacat 3133021 ggcatctgta ataaaaatct gctgatagcc aagctgaaat gcctcccgtg ctgtgctttc 3133081 caccccgata ttcgttgcga tgccgcacaa tacaatcgta tcaatgccgc gacgtctcag 3133141 ctgcaagtct aaatctgtgc caaaaaaagc accccattgc cgttttgtca cagtataatc 3133201 gccatcctgc acaccgattt ccggaacaaa ttcggcccag tccgccggca tttcccctga 3133261 acctccctgc gcaggctcat ccgtttgcgg cttcagggcg tccgctccat catgaaaggc 3133321 tacatttaca aagctgatga acccgttatg tttccgaaat tcatctacga gctttttcgc 3133381 gttcgggaca acctggccgc tttgatcaat cggcacaatt cccttttgta aatcaatgat 3133441 aaccaatgct gttttttgaa aatcaatgtt gagtgtattc atcatacgtc tcctcctgat 3133501 actgttagtg tttctcacat tgcatatttt actcttcaca ctgcctaagt tcttttatga 3133561 tgcttgtgaa attctcagaa ggagcgtttt ctcatgattt ttcttttatg tagtagtaac 3133621 aggttgtgca tacgaacaaa ccggcaagca ctgtaatcat aaagggcgtc atcgcttcat 3133681 cacctgcctg ctgtctatcg gttcctgcct gaaaatgccc atgaatttgc ggcggtccat 3133741 ccaaagcagg ataagacaca taaccattaa tatcgtgcta agatcctgca cgccaatatc 3133801 aaaacaatag ttaatcaaga cgatgttcac aataatgggc ataaaaataa ccgcccctaa 3133861 tgcagccgtt cgcggaatca gtaataaaac agctgccagg atttcaccaa aacctataaa 3133921 cagttcatag acatgagaat aaccgaaaaa tgtccacgcg atcgtaaacc ccttcccggc 3133981 agccgcctcg atttcaggcg tcacctcgcc aaactggcca attaccactt tcgccagacc 3134041 gtacacgaaa aaattaaagg ctaaaaacaa tcggaacgtc gcgggaatcg acttgcgtac 3134101 cgctttcctc agcctgccgc ctttattcat catacatccc cctcagtgta ttatttgatg 3134161 tagtacactt aatacagtat agagtattct aattaatgtc aattcccttt tcagctcata 3134221 tgaatagttt cttttataga tacaaagtct tatatcgcaa aaaatgccat tctccttcct 3134281 ttccatccct cgataacatt tctcaaaaac catgtcagga aatcttacat gaaaatgttt 3134341 tatcattctt ttttctctat aatgaagaaa tataataatt gctttttatt ctgaaagata 3134401 cggaggaatg agacatgcaa atgggcgata cagtttttat gttcttttgc gctttactcg 3134461 tgtggctgat gaccccggga ttagcgttat tttatggagg aatggtaaag agcaaaaatg 3134521 tgctgagcac tgccatgcac agtttctctt ccattgccat cgtttccatc gtttgggtgc 3134581 tgttcggata tacacttgcc ttcgcaccag gcaattcaat catcggcggg ctggagtggg 3134641 caggcctcaa aggggtcgga tttgatccgg gagattacag cgataccatc ccccactcgt 3134701 tatttatgat gttccaaatg acgttcgccg ttctgactac agcgattatt tccggggctt 3134761 tcgcagagcg gatgcgattc ggcgcttttc ttttattctc ggttttatgg gcctctttgg 3134821 tttacacacc cgtagcgcac tgggtatggg gcggcggctg gatcggccag cttggagcgc 3134881 tcgatttcgc tggcggcaat gttgttcata tttcctccgg ggtggcagga cttgttcttg 3134941 ccattgtgct cggcaaacgg aaagacggta cagcgtcttc tccgcataac ctcatttaca 3135001 ccttcttagg aggagctttg atttggttcg gctggttcgg ctttaacgtc ggcagcgcat 3135061 tgaccttaga tggtgtggcc atgtacgcgt tcatcaacac aaacaccgcg gctgcagccg 3135121 ggatcgccgg ctggatctta gtagaatgga tcattaacaa aaaaccgaca atgctcggag 3135181 cggtatctgg ggcaatcgcc gggcttgtcg ccattacgcc ggctgccgga tttgtcacac 3135241 cgttcgcttc cattattatc ggcatcatcg gcggagctgt ttgtttctgg ggagtattct 3135301 cgcttaaaaa gaaattcgga tacgacgacg cgcttgacgc ctttggcctg cacgggatcg 3135361 gcggcacatg gggcggaatc gcaacaggat tattcgcaac aacctctgtt aactcagcgg 3135421 gcgcagatgg gttattttac ggtgatgcaa gcttaatctg gaaacaaatc gtcgccatcg 3135481 ccgccactta tgtttttgta tttattgtca ctttcgttat tattaaaatt gtaagcctct 3135541 tccttcccct tcgcgcaact gaagaagaag agtcacttgg gcttgactta acgatgcacg 3135601 gggaaaaagc atatcaagat tctatgtgag gagtgacgct atgagcggtc aaatgttcaa 3135661 ggtagaaatt gtaacgcgtc cggcaaattt tgaaaagctg aagcaggaac tcggaaaaat 3135721 cggagtgacc tctctgactt tctccaatgt acacggctgc ggccttcaaa aagcacatac 3135781 ggagctctat cgaggggtaa aaatagaaag caatgtatac gagcgtttaa aaatagaaat 3135841 tgtggtcagc aaggttcctg ttgatcaagt gacagagacc gctaaaaggg tgctgaaaac 3135901 gggatcacca ggtgacggta aaatatttgt ctatgaaatc agcaatacga tcaacatccg 3135961 cacaggcgaa gaaggacctg aagcacttta atatcggtac gagattcgga cactccggat 3136021 ctcttttttt gtgcacagaa tccccccaga aaccgcgatt cctcttcgaa ttctcttcaa 3136081 gcgccgttat ttcagacaat ctctattttt atttgaaact tttcatgagt aagattagtc 3136141 tactaaatat aaaaatgtaa aaggtgatta tttgaactac gaaattttta aagcaatcca 3136201 tggactatct catcacaatt cagttctcga ttccattatg gtcttcatca cggaatatgc 3136261 cattgtcgcc tatgccctta tcctattggc aatctggctg tttgggaaca cacaaagcag 3136321 aaaacatgtg ctatacgcag gcatcacagg aattgcaggc cttgtgatca actatttgat 3136381 tacgcttgtt tatttcgaac cgcgcccgtt cgttgcgcat acagtgcata cactgattcc 3136441 gcatgctgcg gatgcttcat ttccaagtga ccatacgaca ggtgcattag cgatttctat 3136501 tgcgatgctt ttcagaaacc gcaaaatcgg ctggccgctt gtcatttttg ggcttttgac 3136561 aggcttttcg agaatttggg tgggacatca ctatccggta gatgtattgg gcagcctcgt 3136621 tgtcgccatc attatcgggt tccttttctt tagattttca gatctgcttc gcccgttcgt 3136681 cgatttggtc gtgaggatct acgaagccat tatcaataaa ctgacgaaaa aaccaaccga 3136741 tcaaaatttc taagaaagac aaaagccggc gtctgaaatc aagacagccg gctttaatat 3136801 ttctcataca tctcttgttt tcttcgcttc gccaacacat ataaaccata aaacaaccca 3136861 attccaacag catcgatgag cacatcccgg atacaaccat tcctgctgaa gaagagctga 3136921 agaacttctg tgaaaaaagc aaacgcaaat gagccggctg cagctgatct tatgctgccc 3136981 cgctgtttcc acagcaaata tgtcagcaca aagaaggaaa acgcgtgtcc gattttttga 3137041 ataaacgctt caggtacagt aagctcagta aaatccataa ctaaaaattg agacagatca 3137101 gggtgcggct gaaaatgaaa agccaccgtt tgcgatacga ccatgccgct gaagctttcc 3137161 gtacagacag aaagcaggat aaaaaagatc cagcctgcga gcaataggcg gttcatgaca 3137221 taacctcctt tataacgtac gtgcctacat gtaactacat agacggtaaa acaaagcaaa 3137281 aagtaacaga aaaaaacgcc catcacaagg atagacgttt tcttcattaa gactgttcag 3137341 tgtcttctgt tgtgctgctt tctttagaac cagatttgtc agttgaatca tcctttttct 3137401 caccggattt ttcttctgtt cctttttcag ttgatccgtc ctttttctcg gaagattgct 3137461 gaatggattc ttctgtttct tgggtggcag ctttttcaat agaagaaact ggtttgtcca 3137521 taaagtttaa cggattcatt gcaaccccat ctttacggat ttcaaagtgc acgtggtttc 3137581 cgctgtcttc actgtaaagg ttcttgccag attttccgat cacttgattt tgttttactt 3137641 tgtcaccttg ctctacgctt acttcggaaa gagattgata cacagtcgat aaaccgtcgg 3137701 catgttctac ttccacaaca tatcccagca ctggatcttt ttcagcttta acaaccgtac 3137761 cgctcagaga agcagagaca tcgaaatctt ttccgtcttt ctcagctaag tcaattcctt 3137821 tgcttaggct gtacgtgtta ttataggtaa cgagtgctgc ttctttctct tcttttgcgg 3137881 catcggtttc atagaacttt ttcacaacag aaacgttttc agaatcaaca accggcattg 3137941 cgacattttc cattgacttt cctacttcaa ctgcatcgtc gttgttgtca tatgcggagt 3138001 ttccgccgtt atcagccaac tgatccttta cctcatcatt tgatactgat tgataccaaa 3138061 ggacagctgt taaaatgacg gccgcactga ctaagtaaat tgcagggaac acccagcgtt 3138121 tacgaaaaaa ctgctgaagt tttttgactt gagaagtttt cttttcttcc tctctcattg 3138181 tttcatcacc tcagcaacat tctgaacact tttctgaaaa tatatacaac ctatccaaaa 3138241 aaactttttt agatgtagtt tgcacagact gaacgaaaat atgtattttt ttgagaggag 3138301 tgccaaaaac gtatgaacat gacattgcgt cttgctgaac atagagactt ggaggctgtt 3138361 gtggcgattt ataattcaac gattgcttct cgaatggtaa cagccgatac cgaaccggta 3138421 actcctgaag accggatgga atggttttcg ggacatacag agtcacgtcc gctctatgtg 3138481 gccgaggatg aaaacggaaa cgtcgctgcc tggatcagct ttgaaacatt ttatggaagg 3138541 ccagcctata ataaaacagc ggaagtcagc atatacattg acgaagcatg ccgcggcaaa 3138601 ggtgttggat catatttgct tcaagaagcg ctccgcattg ccccgaatct tggcatccgc 3138661 tcacttatgg ccttcatttt cgggcataat aaaccaagcc tgaagctgtt tgaaaagcac 3138721 gggtttgcag aatggggact attccccggc atcgccgaaa tggacgggaa aagatacgat 3138781 ttaaaaattt tagggagaga gctttcatga ttagtctgga taaagatgaa aacgaaattg 3138841 aacatcataa tgaagaaaat agccttgttg aacaggagac tgcacctgtt ggacaggaga 3138901 gccgccagct gagcgcctcc gctgtcaagt cgctatccga cattgccaag tggggcaaaa 3138961 tttctggcat cttgttaatc attatgggat cgcttgtcac tctgtctgtt ttgatgacag 3139021 tgattggcgc catcccgggc gtactgctca ttatttcagg cgtatttttg atgcgctcag 3139081 caaaagcagc cgcggaagcc gaaggaaatc taaccggcag cgctggcgaa agcatgcttg 3139141 aaaattacgg gacatttata aaaatgcagc tgttttatgc agcatccagt atcgttactg 3139201 tcctgatcgg gatcattgta gccattttcg tgctggtggt aatcggcatt gctgcttttg 3139261 agaacacgcc ttcgtatgat gatccggatt cttattatta tgaggatgat ccggtgtttg 3139321 aataatgatg agacaggaca gggcatgagt tccatataaa cggaaccatg cctattttat 3139381 ttgactattc aaagcaggcc ggcgtaaaca ccaaatcctg aagcaagcat acaatagaca 3139441 tctctagtag aggaaatcaa caaagcaacg ctgttaccca gaaatgaata tcaaaaaaac 3139501 ggatgaagtc ggaatcaatc cgaaaccgca ctttttattt cgggtgtctg catgcaaaaa 3139561 aacacacccg gatcgtctgg aaaatctcaa caatccgggt gcagatcttc tttaatacat 3139621 ttttttgcgt ctgtcttcct cagtcaaaaa ttcaacaaaa ctccgcatcg caaaaggctc 3139681 ttcctttatt tgtcgtgcgt aggagctttt ccgctcttct gaaaggattt cgctcttttt 3139741 gatcctgttc agcatataga tgtgaaccgt tttttggatt tgtttatgct gatagcctgc 3139801 ctctttaaaa aatgcgagcc cgagcgccgc caaaagggcg aatatgcctg cgctgatcag 3139861 ggactccctg tcagctgaag catgaaatag aaaagcagct aaattaaaga gagagaatgc 3139921 agcaagcgga atagcaagaa aacggtaaat gacggttttt ttcatgaaag gctgtacggc 3139981 cttttgaatt ttttgcattt ctgttttgat gaaccccggc atttgttcga ctctgtaaaa 3140041 gttcatataa tcctccccct ttatttgatg tttcaagctt cacgaacgtt atcatatgtg 3140101 tttattttaa cgcaggtgca agctggtttt aaagaaatct gcccgtattt ttcacgaaga 3140161 atctggatcg ccgctcttta ttcttttaaa atgtgagtgt tataatttgt aatgggaatc 3140221 agatcactgt tattcatgga atactaatgg caatcttctt gataaatatg aatgagcggg 3140281 gttacaaagt gagtatttct tccatccttt tatcactttt tttcatttta aatattcttt 3140341 tggccatcat tgtcatcttc aaagaacggc gcgatgccag tgcatcttgg gcgtggctgc 3140401 ttgttctttt ctttattccc gttttaggct ttattttata cttattattc ggccataatc 3140461 tcagacgcaa gcatttgttt caatgggaag accggaaaaa gattggaatt gaaaggctgc 3140521 tgaagcatca gcttgaagat ttagaaacca agcaatttca gtttaacaac cgggcaacct 3140581 ttgataacaa agatttaatt tatatgctga ttatgaataa ccatgctgtg tttacagagg 3140641 ataattcagt tgacgtcatt acagatggac gggataaatt tcagcggctg ctgagtgaca 3140701 tttcaaaggc taaggatcat atccatttac agtattatat ttataaaggc gatgaattag 3140761 gcaaaaaatt gcgggacgct ctcatccaaa aggcgaaaga aggtgttcag gtcagagtgc 3140821 tttatgatga actcgggtcc agaacgctga gaaaaaagtt ttttaaagag cttcgcgagg 3140881 ctggcgggca tgtggaggtc tttttcccgt caaagctcag gccgattaac ctgcggctga 3140941 attaccggaa ccatcgaaag cttgtgatca tagacggtat gaccggttat gtcggaggct 3141001 ttaacgtcgg agatgagtat ctagggctta atccgaaatt cggttattgg cgggatacgc 3141061 atatccggct gcaaggaacg gccgtgcacg ccatccaaac acgattcatc cttgactgga 3141121 accaagcttc tcatcaccat acgctgacat atattccaaa tcactttcct gattacggcc 3141181 caaaaggcaa cgtcgggatg cagattgtca caagcggccc tgattcggaa tgggaacaaa 3141241 ttaaaaatgg ctacatcaaa atgatttcga acgccaagcg ttccattttg atacaaacac 3141301 cttattttat cccagatgca agcctgctgg atgctttaag gatcgcttgc ctttcgggca 3141361 ttgacgttaa cattatgatt ccgaacaagc ccgatcacgc ctttgtatac tgggcgacac 3141421 tttcgtatat cggcgatctg ctgaaagccg gagccactgt ctatatttac gataacggct 3141481 ttattcacgc gaaaaccatc gtggtggatg acgaaatcgc ttcagtcggc acagcgaaca 3141541 ttgatgtccg aagcttcagg ctgaattttg aggttaatgc atttatttac gatatcacca 3141601 ttgctaaaaa actggtttca acttttaaag aagatttgct agtatccaga aaattcacct 3141661 atgaggagta tctgcagcgc ccgttgtgga ttcgaataaa agaatccgtc tcgcggctgt 3141721 tgtcgccgat cttataagat gcgtaaaccc ccggccttta cggccggggg ttttcctgat 3141781 ggtcacagta aatgatgatt gcctcccgca aaaaagcggc aagaccttct ccatattgat 3141841 tgattgaatc ggtaaatcgc tcgtcagtga tatacacttc cccgagtcct ctgaaaatgt 3141901 cgagtgtgca atcgtaatga tattggcaaa tatgatcgcg aaatgccccc acagcggcct 3141961 gaatctctgc atcatcgggc ccatgcttca ttcgcgccgc aattcgtctg taaatcgaat 3142021 caaattcagc catgatcgtg cgccaatcat ctgccgagta tgcagatgtc cttttctctg 3142081 tttcttctgc gatttccttt ccatacagct ttctgacttc atcagcgtat gtctgctggt 3142141 gctcttcaat gtctttcatg cttaatccgg caaataaatc cctcttattc atcgtttccc 3142201 ctccatcaac ggacaaaagc gtcctgtcaa ttgtttgaat catctcatcc attctttgtt 3142261 ttttcttcat caatatctcc ttttgcgact gaagtgccgc tttccggtca aaattcggat 3142321 gatccagcat ctctttaatc tcatccagac gaaacccgat ttccttgaaa aataaaatct 3142381 gttgcagtct ttccaggtct gcgtcactgt acaaacgata cccagcatca gtaagcgctg 3142441 aaggattcag aagctcaata ttgtcatagt gatgaagcgt ccgaatgcta acgcctgata 3142501 tctccgccac ttgtttaact tgatatttca tacataacac ctcctctttt ttatcgtaaa 3142561 caatcacgca acgttagggt caatccccaa aatgttattt tctatataca aaacttctca 3142621 caaatagtgt ataaaagaaa agtgagtatt tttttgtaaa ggggagccag tatacatgaa 3142681 tcctgaaaca atgaacaaaa ccctcatcag catttcgaaa tggggaaaag ctacaggcat 3142741 tttatttatt attatgggcg caattaccgc gctttcaggc gcgttctttt ttctaatcgg 3142801 tgccgtgcca ggcgtactgc aaattatttc cggtatcttt ttgatgaggt cagctaggga 3142861 agcaggccaa atggctgaac acaatagcgg acagtctgaa gacttaatgc tggagaatta 3142921 cgcgaaattc gtaaagatgc aagggattta tttgatcgta agcattgctg tatccattct 3142981 tgcgattatc gccttcttca tctttttaat gcttgggatt gctgacggcc ttttcagcga 3143041 tacgtacagc acttattaat gagaaaaacc cggagctggc tccgggtttt ttattattcc 3143101 gcttcgctta ccactgtgaa gcgttcattt ttgtgttcgg gatgttcaag ctcgtccaac 3143161 acggcaatgg cataatctgc atagctgata tagctgtctc cttttgcatt tacgatgaca 3143221 ttgtcttttc ctttttggta agagccagtc cgttttcctg ctggatcaaa aaatgccgca 3143281 ggactgagga acgtccagga aatggagtct gtctgctgca aatctttcag gttctcgcct 3143341 tgatttgatg cagttggcaa atattctttc ggaaattccg gcgtatccat taaacgggtt 3143401 gttttggctt catcaacaaa caggcttccc gctccgccaa caacaagcaa tcttgtgtgc 3143461 ttcgcgtcct ttaaaatgct gatgagtgct cttcctgctt caacatgaag atgttcttgg 3143521 ccgggtgctg ctccaaaagc gtttacgacc gcgtcgaaag gcttgatgtc ttccgcagtc 3143581 agttcaaaca catctttttc caaaatcgct acgtcttgct cctgcacttt tgaagcgttt 3143641 ctgacgatgg ctgtcacttc atggcctctt tttttcgctt ctttcaaaat ctcgtttccc 3143701 gctttcccgc ttgcgcctat aataccaatt ttcatttttc atttcctcct tatttgtaac 3143761 aattttagtt acatgttagc ggtgagaagt catccctttt gattaaaaga gatgattcat 3143821 aacatctttt aatgacttgc ttgccagttc attttccatc gctctttgca cactttcaaa 3143881 cgtttcatcc agagcgttct gaattttttt ccctaccgga catttcggat tcgggttttc 3143941 atgaaccgca aagagttctt cttgcttttg gacagcccgg tacacttcta aaagagaaat 3144001 atcagcagga tcttttttga ggcttgcacc cggcaccccg gcgcgtgatg tgagaatatc 3144061 agcttttttc agcaggctga tcattcttcg cacaactacc ggattcgtgt tgacactgtc 3144121 tgcaatgatt tctgaagatg ttttttcatc catcgagatg agggataaaa tatgaatggc 3144181 aacagcaaga cggctgttaa tcatgttttt tcaccaccgt tgtaactata atagttacat 3144241 ttgattcgtt tgtcaacatc taatatacac taaatacatg ggttttgtgc accgttttta 3144301 gtcaatagaa cggccggatg cactccggcc gcgtcttatc aaaataagaa atatctttgt 3144361 ccaagtggga cataatcgac aggctggcaa gacaattcct ccccgtcagc aaagacctga 3144421 taggtttttg gatcaatctc aatcttcggc aaagccgaat tcagcttcat atccagcttg 3144481 ctcagctttc tgatattttt gactggagaa atcctttttt ccagccctaa gctttccgcc 3144541 acaccacgct ctatgcttgc ctgagacata aatgtaatcg aggttgagcg gttggctttt 3144601 ccgtaagacg catacatttg gcgcatgaaa accggttcag gagtcgggat ggacgcgttc 3144661 ggatctccca tttgcgcacg tgcaatcatg ccgcccttta agaccagttc cggtttcacg 3144721 ccgaaaaata ccgggtccca cagaacgaga tcagcaagct tccctttttc caccgagccg 3144781 acctcatggc tgagcccgtg cgtaattgcc ggattaatcg tgtatttggc aatgtaccgt 3144841 tttgcgcgca cattgtcatt cccgttttca ccggcaagag cgccgcgctg ttttttcatt 3144901 ttatcggcta cctgccatgt tcggatgatc acttcaccga cccgccccat cgcttgggaa 3144961 tccgatgatg tcatgctgat cgcacctata tcatggagaa tatcctccgc ggcaatcgtc 3145021 gccgccctga ttctggaatg gctgaatgcc acatcttcag gcactttcgc atctaaatgg 3145081 tggcagacca tcatcatgtc aagatgctca tccatcgtat taacggtata aggaatggtt 3145141 ggcgttgtag atgacggcag aatgttcgcg taagaggcga gcttcataat atccggagcg 3145201 tgaccgccgc ctgccccttc aatgtgataa gtatgaataa cccggtcccc gatcgcgtcg 3145261 agcgtgtttt ccaaaaagcc cgcttcgtta atcgtatcgg tatggatggc aacttgaata 3145321 tcagcctcgt ccacgacttc catacacgtt ttaatggcgc ttggcgtcgt tccccagtct 3145381 tcatggagct taagaccgat ggcgcctgct tccacctgct cgatcagcgg cgctttatcg 3145441 gatgcattcc cttttcctaa gaagccgaca ttgatcggaa actcctcggc cgcttccagc 3145501 atcctcgcca tataccacgc cccggacgta catgttgtcg ctttgcttcc tgtagcgggt 3145561 cctgttccgc ctcccaaaag ggtcgtcaca cctgaagaaa gcgcaacttc catctgctga 3145621 ggacaaataa aatgaatgtg cgtgtccact cccccggctg ttaaaatttt gccttcaccg 3145681 gaaatcacct ctgtccccgc tccgatgacc atgtgcggat cgactccatc catgatatca 3145741 ggatttccgc tttttccgac accgacaatc cggccgtctt tcacaccgac atccgctttg 3145801 acaatgcctg tgtaatccaa tagcacgacg ttggtgataa ccaaatccaa agcgccgtcc 3145861 ttccctgtga ttctgccgtt ttggcccatg ccgtctcgga tagtttttcc gccgccaaag 3145921 atcatttctt caccgtatac tgtgaaatcc ttttcgactt cgatccataa atccgtgtcg 3145981 cccaatctga ttttatcgcc cgttgtcggg ccaaacagtt ccgcatattc ctcccgtgac 3146041 attttcatcg gattacaccc tccatccagc cggcttgttt taagttggcc aacgtttttt 3146101 ctttgccgcg ttcatcgata aacgtgtcgg ccattccgtt cagccctcta attgtcttgc 3146161 gtcctctgat ttccactagt gagaccgttt tctgctctcc cggctcaaaa cggaccgacg 3146221 tgcctgatgg aacatcaaga cgcatgccga tcgccagctc acggtcaaat aataaagccc 3146281 cgttggcctc cgcaaaatga aaatgcgaac cgacttgaat ggagcgtgat ccggtgtttt 3146341 ttaccgttac ctcccgtatc tcacggcctt cattaatcgt aatggttccc tcagcaattt 3146401 gaaatgctcc cggcttcatg acttcacctc cgcagaaatt ggctgatgta ccgtaacaag 3146461 ctttacacca tccggaaatg tggcctccac ctgaatgctg tccagcatct caggcacacc 3146521 ctccatcaca tctttttccg ttaatacatg gcggccggct tccatcagct ctgctactcc 3146581 cttcccatca cgtgcgcctt ccataataaa gcaggtgata taagcagcag cctcaggata 3146641 gttcagcaga acgccccgcg cctttcgctg tttggctaat tcccccgctg caaaaatgag 3146701 caatttctct tgttcaactg gtgtcagttt catctgtagt cctccttctt ttgtcatata 3146761 aagcagatgc ggctactacg aatttgcgga acagtcaggc gggacatcac ctccctttct 3146821 tcgagaatgg gggtcatacg gtaagatgcc tttcaaagcg gcatgccgtt tcttcatcag 3146881 ccttgccatg gtcaacaacc gttcccctgt cgatcacgga aagatcagat taacgcgttt 3146941 tccagactgc gctcgactaa gataacaaat gtcttttttt ctggaaattt ctataataac 3147001 ttgtctgact agttcgacaa ttaaaatctg aattccttcc aattgtttat taagtaaaat 3147061 atttttcaga tttaccatca gcgctctggt gattgcaagc tgctgctgtt gaccgccttt 3147121 tcgttttgaa caaacgtttg attaaaacaa atagccccct ctgtttagcc ggagtcggcc 3147181 taatacagcg acaatctgcc ccgggcgaag ctaaggctgt gcaaaaccat cgattgatca 3147241 taaccagacg ttacattcct gatggcagcc cgttgttttg ctccgcaacc ggaagcatgg 3147301 catggaggcc agtctgaggc gccgacctcc acgataccga gaacccgact attgccatta 3147361 actccgcatc atggacggtc acttcgctga tcgccaccgt tcctcttaat gagtgaagaa 3147421 ttccggcctt cactgaatcc ccgcttgtgt cgatatcaac tgttttctcg cactcccgtg 3147481 gcttccgaca ctttcttcgg tgcagtacat tccgtcatca aaaccccttt gtttgatttc 3147541 ttcaaatgat gttataaaag tttacaactt atgtcatcat tatatagaag aggcctatta 3147601 attcaaagaa tatttaaaaa atttagttac cttgaccaaa tcagcttctt tttttgttat 3147661 atttattcac atcagaaaaa gcgaaaaaaa aagacaagaa acatttcgtt tcctgcctct 3147721 tccgtacgat taatctttat ctgaaaattt atccttggct ttcccgatat ccttttggat 3147781 ttcgcctttt gccttatctt ttttgccttc agcctgcatg tccgttctgt cagccatatc 3147841 tccgacttta tccttcactt ctcctttggc tttattgaag ccgcccttca ttttgtcttt 3147901 tacactatcg ttacccatgt taattctccc ctctcaatta tgtgtgtact tgttaacttc 3147961 ccgatctgag aggcaataaa cattctaatg ttatttatcg atttcgtagc gctctccgta 3148021 acggagcacc ttgtatatcg ccagcccgtc tgatgacttt ttctccgaat atcggaccgg 3148081 cagcagggca aaaaacacat aatacgtaga aaaatagaca aactgataga aaaacacatt 3148141 cggctttaat acactgtgta taatcagcag attgattgca aaaatcgtga tgaggttaaa 3148201 caagcagccc cctgcataca cgagtgcatt tgagaatcga ttgtcaattt tcaactcccc 3148261 gtaccggcaa aaagaatcga taaaataaat cgttctgaac cgtatgggtc caattttaag 3148321 cagcgttttt cccatgccta tatccaacga tccctttccg ccaaaaataa aagccataaa 3148381 gctgtgccct gaaacatgta taatctgtac aagcggcaga acaatgagga aagaccacag 3148441 aaacttcacc atatcattaa aaccaaacat tgaattcccc ctcacatgca tatctgcatc 3148501 ccaaaacggc ttttgttcaa aaaacagtgc tgtagcgatt tttcctgttc tccccggaaa 3148561 taaacgttcc gatgctcccc tttttttgca taaaaaaaaa ccatctgcca gcagatggtt 3148621 ttgtctcata cttcatataa acaatcgttc ctttgaatca tctctctcat gctgaccgct 3148681 ttttcataaa aatacaccgc ttctttatat tgttcgcgat gactgaaata agaggcagca 3148741 tctaaagcaa attcttcaat atatacatac aggccctttt cttccatata atcaaatact 3148801 tcttgaatca tattcaaatt gacagattcc acatataatg cctgcagaaa tttatatttt 3148861 gccagactga agaagtcgtt tcgtttttgg gcaatggcaa tccctttttc atagtaccgt 3148921 atcgcggctt cgctatcttg ttttttgaaa agaacgcgag tcaggctgaa gagcgctttt 3148981 ggaagctgtt ccagctgata atcctcgaag acaggaagcg ctttttcaaa gtattcggcg 3149041 gcctgatcca gctccccctt gtcatcatag caattaccaa tattataaag ggctgatccg 3149101 atcaaacggg gctgtccttc caataaagca aggcgatacg cgtcatctaa atgttcaagc 3149161 gctttttcat aatttctgta gtcaatgtag tttcctgata tgacgaaatg gcattgaatt 3149221 cttctgactc tgtaaaaatc gtgagcctta tacgtctcca gcgcctgtac ggcatggttc 3149281 atggaaaagt gcgtctgctt cataatataa aagacttccg ccactttaaa atgaaattcc 3149341 gctctttcaa tttcatcttc tacaaacgca agcatcttct cagctttccg ataaaaggat 3149401 atagccgaga tgtaattgtt ctgttcaaat tcgtacattc ctctaaacaa gtgaaaataa 3149461 tactcagata atccggagat gctgtcctga ttgctttcca gcgttttgat caattcacga 3149521 tattgaagct gagattcctc gtgcaggtca ggctttacat aatccagcat aatttggtgc 3149581 cggtagctga tcagctgata atacaggaga agcagctgat cctcttccat ctgttcgata 3149641 tctagatcaa tttcttcttt cagttttacg gcatcagcca cttgaaatgc taaaatgtgc 3149701 ttataccact tattgatttt cactcctact tgagatgacg ggatctcgta cgcggccatg 3149761 cccctccaac cctttctatt ttctaattgg ttatatttta tcataatgta tggctttgga 3149821 attaaatttt cttacaatga ttccttcttt atgcctatcc ttatatattt cggtttttct 3149881 acgtattttt tgcactcgga ttctaataaa aaagcttacc ggacagtgcc gataagcttt 3149941 tgacttcaaa ttaaccgcca atataagaca tttccacttt ctttttgcca gatgcttttg 3150001 atagcgtacg atcgactgaa tactgatcga tccgattttt ccatactgtc ccgatcattt 3150061 ctgatagttc gtcatcactt aattcctggc gaaccggagc tctgaggtca aatccgcttg 3150121 aagcgaataa gcaggtaaac agctctcctc tcgcagaaag acgggctctg ttgcaagatc 3150181 cgcagaatgc atcagataca gatgatatga cgccaatttc tccggagccg tccaagtagc 3150241 ggaatctgga agccacttcg cctatataat taggcgctat cggctcaacc ggcatgtgtt 3150301 tattgatcaa atctatgatt tccgcctttg tcatgacgtc tttcttttcc cattggttgg 3150361 tgttgcctac gtccataaat tcaatgaatc tcaggatatg ccctttttct ttaaaataac 3150421 gggccatagg cagtatatct ttttcattga cgcccttttg aacgaccata ttgattttaa 3150481 caccgagccc cgcttgcttc gccgcttcaa tgccttccag caccttgctg acagaaacac 3150541 cgcgcccgtt tatcttctta aaacgctcgt cttctaaaga atcaaggctg atcgtaaccc 3150601 ttttcagccc agcctccttg agcctcttag cataaacagg cagcagtgat ccgtttgtcg 3150661 tcatcgcgat gtcacgaata cccggtatgc gggccagttt tttgattaat tccggcatat 3150721 cctttctcat gaggggctct ccgccggtca agcggatttt ttcaacgcca aatcttgtga 3150781 caaacaatgt cgcaagccgt tccagctcct caaatgaaag cagctcctct ttctttaaaa 3150841 aaggataatc cgggccgaat aattcggcgg gcatacagta cgtgcatcgg aagttgcagc 3150901 ggtctgtaac agaaatgcga aggtctctca gcggtctgtt tcttttatcc aacatctgac 3150961 gcgactctgt aatcatagct acagcccctt cctactccct gattctctca gggtgtgtat 3151021 atacattaaa tgatccgttt ctgacaaatc caatcgctgt gatattcaat tcttcagcca 3151081 tttgaatcgc aagctccgtc ggggccgatt tggaaatgac aatcgacacg ccgattttgg 3151141 ccgcttttaa caggacctct gatgagattc tgccgctgaa cacaatcagt ttgtcgcgta 3151201 cggacatccc gtttagaagg cagtgtccgt atagtttatc aagtgcgttg tgccgaccga 3151261 tatctgtgcg catcaacaga agcttctctg tgtcgcaaag cgccgcatta tggacgcctc 3151321 ccgtatcctg aaacgtcccg ctcccttgct gcatgtcttt cataagcgcc agacatgcct 3151381 caggcgatat cttgatttgg ctgacagccg tcttggctgt tttgacatcc tgctgaaaat 3151441 aaaaatgacg gccctttccg cagcatgagc cgatcacccg tttcgtataa tccttttgat 3151501 ccaatgtctc agggtgaacg aggtcgacat atacaaaacc gagactttca tctattgtaa 3151561 accttttaat ttctttttga aatcgtataa caccctctga tgcgagaaat ccgatgacaa 3151621 gctcttcgat atgctcaggc gtacaaacga gcgtcacaaa ttcactgcca ttcagtatca 3151681 ctgtcaaagg gaattccgtc accatccggt cttctacttt gcttatttcc ccttgttcat 3151741 agcgccatac atccctgacc gcagttactt tatcgttcaa tgtctcttcc cctccgcaat 3151801 gttcctgcct ttatattttt tcacactcct cggattttgt cgaattctga gacacaaaaa 3151861 gagccctcta tataaagggc ttttacagga tgtgatgacg gcggtgttta ggcaggacgc 3151921 ctaagcattt agccgccgtt ccttttataa cacgtgagca ccaatgtgca ttgacaacga 3151981 acgcggggtt tgtcgacacg ctgagacacc tctgtataaa ggactctatg tttgattatg 3152041 ctgattcttt ttcagaaccg taaacagcac aatagctgcg atcaaggtga gaatgctgac 3152101 aaaaaagaag gctgccagtt ttagaagaac accaagcaat ataaatgcaa cggtggctat 3152161 aagaaaaatc attccgaata atttcatatg ttcaacccct ttttagggta tcattcccgc 3152221 ccaaactgtt tttaaaccaa taaaaaaggc gcctggggga gcgcctgatc tttaggttcc 3152281 ttactcagta aatttttgtg cttctttttc ccaagcctgt tcgaactcat ccgcactgtt 3152341 cgctgaaata tattctccgc cgccagcgac agctgcttgt ttcatctctt cattaccctt 3152401 gacatcaaag ttgaagccaa tgatgtttac aatcgtatcc acatttgatg cacggagctt 3152461 ttcgatttcc gccgcagggt ctccgccgca cgtttcttca ccgtcagtga ttaaatacac 3152521 cacgtttttc ccgtctgcgt caaatgcttc aaattctttt cttgtgtctg caagtgcttt 3152581 ggcaatcggt gtccatccag tcggcttgag ctcactcaat gaattgtcaa acagagaccc 3152641 ttcatatgga tgaaggccgt aaatggtttc cgtcgtactg cacgaaaggg ctttaccgga 3152701 cagtttattg ttccctgcat gcccgaaaac gcgaagcata agatttgtat cctttggaag 3152761 aagttcggca aaagatttta ctgatttttt ggcaatgtct attttgcgct ctcctcctgt 3152821 tttttgaacc atgcttccgc ttccgtcaaa caaaacagct acatttgtat cagcctgttt 3152881 ctcagcggca aaagacgggg aggcaatgga aacagtcaac aatccaatga taccggcagc 3152941 cagcaatttt ttcatatgat tacttccttt ctttttcata ttttccaact atatgttgga 3153001 ttcttcttta tgctagaata cgaaaatgca aaaagatata ggacatgctg ccttttgtgc 3153061 tgctttcacg atctgtccaa aatcgcttga aatgccgttc atttttagcc atttccgccc 3153121 agaaagcata aacagcttgt gtgatcattc attctttttt cgccttgatt atgacagaaa 3153181 aacggaaatc tgctactatg ctacaggcag acagctaatt agttttgaag tttttgttac 3153241 atacaaaaag aggctgacca tcaccagcct cttttttctt atttagataa cattagtgat 3153301 tgctgagtga aaattttctc aacatctttt tgggtataag ccgggaagta ttcaccgccg 3153361 cctactttcg caattgcgtt cagctggcct ttgtatccct ctttataatc aaagccgatc 3153421 acattaacag tgatattgtc tttttgcagt tcctttgctg ttttaatcgg gtttcctccg 3153481 cacgtttcct caccgtctgt caacagatac accacttttt ccccttttgc atcaagctgg 3153541 tcaaaagaag atttcgcctc gttcagcgct ttggcaattg gcgtccagcc agtcggccca 3153601 attgtattga gagaattgag gaagctttgc tcgttaaagc tttggaagcc gtatacgttg 3153661 cgaatggctt cacatgactg aacttttccg gaatttttat tgtttccttc agagccaaac 3153721 acgctcattt tcacctgagt tccttctggc aatgagctcg caaactttga aatttctttt 3153781 ttggctgaat taaatttaga tacaccatct attcttttcg ccatacttcc gctggcatca 3153841 agcaagaccg ccacgttcgc cggcgcttta gcctccgttt ctgtcttttc agctgcaaaa 3153901 gcaggtgaag ttaatccaaa aagcaatcct gtcatcatga tcagtgaaaa tcttttcttc 3153961 atgttcgtac ccctttacca atttgtttct gcgtgcagat gttcaacgct gaacataatc 3154021 tatcgtaatc aacaaaaacc gagaaataaa tagggcgggc ttccccattg ctgttgttta 3154081 cttttgcata gaaacctatg tttttattag tgatttccac ctaacgcccc tatgaaaaga 3154141 gaagattgtc cgcctttcgg ctttcgttat atgagtctgt cgaagtctgt cgacaaatgt 3154201 ggatgacttt accacaatct caaagcctga aatcaggaaa aaaggactga tccttaaaga 3154261 cggtcagaag ctcctctaaa ccgtttcagc tactcttaga taaaagatat tcaggaacag 3154321 aaaaagacgc ccaatgagcg tctttttcta ctttttcgcc atatatttat tcaaaaacgc 3154381 atctgcctca gaaatttgtg tgccttggta atagtacttt acaatgtcat caaccgtttt 3154441 gccttctttg gccataaaat tcgctccgta ttggctcatc cccacaccgt ggccaaatcc 3154501 tctcgtcgtg actgtaattg tgtctccatt tcgcttccat tcaaaatcgg cggagttgag 3154561 acccaacttt tcacgtatgt ctcttccttt cagcgtcttg ccgttaatga cggcagttgc 3154621 gacctggtgg cccggtgtct cgccggtaat cttccctact gcgctagatc catccagctt 3154681 gacgccaagc ttttgctgaa attctgccgc tgtaaaggtt ttcgttgcct tatatttcgg 3154741 agacttttta tcccatgggc ttttgacgct ttttaaatat gggatagcac ttgtccaata 3154801 agcttctgca ttctctgtgt agccgttgct tgtggagaaa aaggatgctt caatcggctg 3154861 gttgttgtac gttaagattt tgccttgcgt actggctacc gcatctgtga ttttcttcag 3154921 ttttgtctca tagcttgtgc cccactgttt tttcagctcc gctttgcttt tatacacctg 3154981 gaacatctgt gtatcatcca ccagtgagcc tttaggagct tctaccgctg aatttgacac 3155041 catcagtctg acaataaatg ttctggcggc aagcgcctgg gctttcagcg cttcaggttt 3155101 aaaggttgcc ggcatttcgg aggcgacgac tccaatcaca tactcttcaa gcggaatgtt 3155161 ttctacggat tgatttgcgg ttcgatagac gggaatagaa acaggtgatg ctttcaatgt 3155221 ttctgctcct ttcgatgctg gtttcgtgct gactgctgtc ttttctgatt ctacgctggc 3155281 ccccgcttcc ttattatgct ggaatggtat aaccaagagt gtgggaacca agagaatcaa 3155341 tgcacatagt acggatagtg tgattgcgaa ttgtttcata ttcagctgcc tcctgctcgg 3155401 gattcgactc tagtctagtc tatgggcagg gacaagctaa tatgactctc gttttggaca 3155461 gaaactttat ttgtcattta cgtattcttt tttgctattt tgcgcataat gatgataata 3155521 cacaaaaaat aaaaaaccag tatgccagag tgacatactg attttcaagt aagtttatgc 3155581 atttaagtca gaaacgactt ctttattctc ttgctcagaa gcagactcat catttacacg 3155641 ttcgatgtct gcgcccagag cggcaagctt ctgatggaaa tcaacgtaac cgcggtctaa 3155701 gtgcttcaat tcagtaacac gtgtgtgacc ttcagccact aaccccgcaa gaatcagcgc 3155761 tgcacctgca cgcaaatcag tcgctgcaac ttcagctccc tgaagctgta caggaccgtt 3155821 aatgatgaca gaacgtcctt caatcttgat atcaccattc atacggcgga attcttccgc 3155881 atgcataaaa cggttttcaa aaacggtttc tgtaatcatg cttgtgccgc ttgcacgaag 3155941 cagaagcgcc atcatttgtg actgcatatc agtcgggaag cccgggtgag gcattgtttt 3156001 gatgtcaatc ggtttaagct ctttcgggcc gatgacacgc agaccttcac cttcatcctt 3156061 aattgttaca cccatctctt ccatttttgc aattaaagag gtgaggtgct caggaaccgc 3156121 tccttttact aatacgtttc cttcagtgat tgcagcagca accataaatg tgcccgcttc 3156181 aatacggtca ggaataatat ggtgttttac gccgtgaagc ttttcgactc cttcaatttt 3156241 gatggtgccg gtgccagctc cgcggatttt tccgcccatg ccgttgatat agtttgctaa 3156301 atcaacgatt tcgggttctt ttgccacgtt ttccagcgtt gttgttcctt cagctagagc 3156361 ggctgccata atcaggttct ctgtagctcc tacacttggg aagtccagat aaatttttgc 3156421 gccttgcagt cggcctttta cttcagcttc aatgaagcca ttaccgactt tgatttctgc 3156481 gcccattgct tcaaaacctt ttaaatgctg atcaatcggt ctggaaccaa ttgcgcatcc 3156541 gcccggaagt gcaactcttg catgacctgt acgcgcaaga agcggcccca tgacaagcac 3156601 agacgcacgc attttacgaa catattcaaa aggtgcttca gtttgcaaag cgtatgaagc 3156661 atttacagtc acttcattat tttcaaaatg cacatctgct cctaaatgac gcaacacttc 3156721 gttaattgta tatacatcgg agagcgtagg tacatcacaa attacgcttt tttcttcact 3156781 tgctaataaa gatgcagcga taacaggtaa aacggcattt ttagcgcctt caactttgac 3156841 tgtgccgttt aacttctgac cgccgcggac gatgattttt tccaaggtat tcccctccgc 3156901 gtccctaaat tctctatatt aatattcagt cgtaacgatt ggtgtgccaa ccgtaacggt 3156961 atgttttccg cccattcctg cacttctaag tgcaatttgc aaattcattt tatgtttcga 3157021 ggtcataatg tactcttccc actcatctgt aaacgcagaa atagaaacga aatttggctc 3157081 aactacatgt tctactgatc ttgcttgaaa ttcatttaat aactgatttg cttttttttg 3157141 caaaacaata ttcatattat catctaagtg accatttaga caagtaaaaa taactacttt 3157201 ttcttggaat atcccaagtg tctcccgttc aaactgttca tatgtatcat tccagctatc 3157261 cggtgtctct agactcattt gctcatataa taaatacgaa gttggattgt gttttttgag 3157321 ggttgtgaca agctgcagtc taaaagaagt acgatttttt ttgtcagtat atgtgccaat 3157381 tgcctttatc attttatctt cccgtgcaat cacccaatca tattgacgat actcttgttt 3157441 taaacgttgc actttttgat aaaattcttt ttcggtcagt gacaagtttt gttttgcatg 3157501 caatgtccac ttatctattg acacatcttg acgttccatc ccctctgcca tctgtgctaa 3157561 cggcgttaat tcactcgcat gaatggtatg gaaaacagca atgacgaagc ttaacatgac 3157621 ggaaatgata atagcgtggc ttacttgttt tttcttcatg ttcatctctc ccccttatcc 3157681 ccagttttac cggaggcaag aggcgccata cgtaaaaatc ttcgtcaaaa ctcgagctat 3157741 tcgcttcaac ccgcttctcc caaccattta ataatgttca aaacctatta aaatagatag 3157801 ggaagctgct gtgaataatt gaggtaatct aaaaagaaat tggcaacggc cgttccaatg 3157861 gcgattgtca gcaaaatcat caggagtctt gcctgcacga ctttgccttt tttgattaac 3157921 ggatctatat tgacggcttg caacgcccac caagtcactg ctataaaaat caggtgaacg 3157981 acaatgccga ttgcagcctg ctgtcccaat acactcatct attacactcc tttctctgcg 3158041 ttcataccct ttcttattat ataagaagca cagataaaga tgatacattt tatacagaac 3158101 ggaataatca gccaaatcta gggctaatcc ccgcttaaag tgcgattctt ttacatggta 3158161 tactttattg gaaaggagct ggcaaatgtg aatcattctt tttttcagcc tgaaaagcaa 3158221 tatggtgagg acctgccaat ttttgatcag gaatgggaag caattgcatt ctattatgat 3158281 tatagacagt cacagattga agaactgaat gaattgtgtc agttttttaa catttctctt 3158341 acctatacga gagaaagcct tgaagagctt gaaaacctct attttcaaag tatacaagaa 3158401 cttttgcttg ctgattggaa tcttcctatt gaagaattcg agaaaatgat cagtgtttat 3158461 cttatagatt gtgtgattgc ccgccatgaa gatgctgaat gggttgtaaa accttatccc 3158521 tataaagacg gcgcttatac acttggcttt agaagacatc gcaaatcgtg gcatacaatg 3158581 aatgcctgtg atggtttata cctgcgtcca aaagaggatc gcccgttgct gtcgctgttt 3158641 gattctcttg tgcgttcata aaaaaatcct tctcataaag agaaggattt tttcttattt 3158701 ccctgctaca tccaatctgt tcaaagcccg ctgtaacgca agctcagccc gacgaatgtc 3158761 agtatcatct gattgagaat tcaaacgctc ctgcgcccgc tggcgtgcag cttcagcgcg 3158821 ctctttatcg atgccttccg ctgtctcggc agcctgggca aggatggtga catgatcagg 3158881 acggacttct acaaaaccgc cgctgacggc aaccatttca gtctgcccgt cttttttcag 3158941 acggacagcg ccgattttaa gaggagccac ggttggaata tggcctggca aaataccgag 3159001 atcgccgctt tcggctctca cactcaccat ttcgatatcc gcatcgtata ctgggccgtc 3159061 gggagtaacg atattgactt taacggtctt catgctttta ccctcctagg accagattaa 3159121 acttctacac ccatttcttt tgctttctca acaacttctt cgatacggcc tacaagacgg 3159181 aatgcatctt ctggaagatg gtcatattta ccggctaaga tttctttgaa gccttgtacc 3159241 gtctctttta caggcacgta agaacctttt tgtccagtga actgttcagc cacgtggaag 3159301 ttctgagaaa ggaagaactg gatacgacgt gcgcggtgaa cgacaagttt gtcttcctcg 3159361 cctaattcat ccataccgag aatcgcaatg atatcctgaa gctctttgta acgctgaagc 3159421 gttgactgta cttcacgcgc aaccgcatag tgctcttctc caacaatttc aggagcaagg 3159481 gcgcgtgatg tagatgccaa cggatcaacc gcagggtaaa tacccatttc agttaattta 3159541 cgctcaaggt ttgttgtcgc atccaagtga gcgaacgttg tcgccggcgc cgggtcagtg 3159601 tagtcatcgg caggcacgta gatcgcctgg atagatgtaa ctgatccaac gttcgtagac 3159661 gtgatacgct cttggagctg acccatctca gttgcaagcg tcggctgata accaaccgct 3159721 gaaggcatac ggccaagaag ggctgaaacc tctgaacccg cttgtgtgaa acggaaaatg 3159781 ttatcgatga agaacagtac gtcctgtcct tgtacatcac ggaagtgctc agccattgta 3159841 aggcctgtca aagcaacacg catacgtgcg cccggcggct cgttcatttg tccgaatacc 3159901 atggctgttt tgttgattac gccagagtca ctcatttcgt agaaaaggtc gttcccttca 3159961 cgagtacgct ctcctacgcc ggcgaataca gagataccgc cgtgctcttg cgcgatgttg 3160021 ttgattaatt cctggattaa tacggtttta cctacaccgg caccaccgaa caatccgatt 3160081 ttaccgccct taatgtaagg agcaagcaaa tcaacaactt taatacctgt ttcaagaatt 3160141 tcaacttctg ttgaaagctg atcgaatgaa ggcgcctgtc tgtgaatcgg atcctttttc 3160201 gcatccgcag gaaccggctc attcaaatca atattttctc cgagaacgtt aaatacacgt 3160261 ccaagtgtta catcaccaac cggtactgag attggcgctc ctgtatctac agcttccata 3160321 ccgcgctgaa caccatctgt agatgccatt gcgattgtac ggactgtatc atcacctaaa 3160381 tgaagagcga cctcaagcgt taaatcaata cctacttcgt tttcacttgc agctggctgt 3160441 gaaattttaa tcgcattata aatttcaggc aagtgaccgt cttcaaaacg cacgtcgacg 3160501 accggtccta atacctggct aacgcgtcct ttcttcatcg ctatccctcc tgacaaaatc 3160561 tttctattct aaagcggctg ctccgccgac aatttccgta atttcttgtg tgatggctgc 3160621 ttggcgagcg cggttgtaag aaagcgaaag tgaatcgata agttccttcg cgttgtctgt 3160681 cgcgtttttc atcgccgtca ttcttgcagc gtgctcactt gctttactgt caagaagcgc 3160741 accgaagatt aagctttctg catattgagg aagcaaaacc tccagaacct cctcttcaga 3160801 tggttcaaat tcataagacg ccgttctttt tccgccgccg ctgcccaaat cagataacgg 3160861 cagaagtttt ttctccgtta cttcttgagt aatggcgctg acaaaatggt tataaacaag 3160921 gtgcaattca tcaaacgcac cgtctataaa catttgaatc gtttgacggg caagatcttt 3160981 aatttctgta aacgttactt catctccaag tcctgttaac tcggaaatga tcggaatctc 3161041 ccgtttctta aagaaatcac ggcccactct tccgatggca atcaccgcat actcatcctt 3161101 agactgatga cgttcttgca tggcctgata agcactccgt aaaaccgaac tgttaaaagc 3161161 gccggcaaga ccgcggtcag acgtaatgac aaggtatgcc gtttttttca cttctctgct 3161221 gagaagcatc gggtgcttca cgttgccgga aactcttccg acgtttgaca caacctcttg 3161281 gattttatcc atatatggca caaatgattt tgcattgttt tcagcacgat tcagcttagc 3161341 cgcagatacc atctgcatgg cttttgtaat ctgacttgtt tttttcgttg acgtgatcct 3161401 tgacttaata tcgcgtaatg aggccaaaga tttcaccacc ttttctcttc atctgcgtaa 3161461 aaagagagaa aaagagaacc tttttctctc atcagcattc gagttagttg cttggtgcaa 3161521 atgtgcgttt gaagccttcg attgcagctt tgaagtcttc atcagcagga aggtttcctg 3161581 ttttcgcaat tccgtcaagc aggtctttat ggttttggtc aaggtacatg tagtactctt 3161641 cttcaaaacg tctgatatcc gccacaggaa tatcatcgag atatcctttt gtcagcgcat 3161701 aaagaatagc tacttgcttt tcaaccggaa gcggcttgtt cagatcctgc ttcagcactt 3161761 caactgtacg cgcaccgcgg ttcagttttg cctgagtcgc ttggtcgagg tcagaaccga 3161821 attgagcgaa tgcttccagc tcacggtatg acgcaaggtc aagacgcaaa gtacctgata 3161881 cttttttcat cgctttgatt tgcgctgagc cgccgacacg ggatacagac aatccggcat 3161941 tgatcgctgg acgtacgcct gagaagaaca aatcagattg caggaagatc tgtccgtcgg 3162001 tgatggaaat gacgttcgtc ggaatataag cagagatatc tccggcttgt gtttctacga 3162061 acggcagagc tgtaattgat cctgcgcctt tcgcgtcgct aagctttgct gcacgctcaa 3162121 gcagacggga atgaagatag aatacatccc cagggaacgc ttcacggcct ggcggacggc 3162181 gaagaagcaa ggacagctca cggtaagcgg ccgcttgttt agaaagatca tcgtatacaa 3162241 caagaacgtg cttgccgttg tacataaatt cttctgccat tgtaacccca gcatacggtg 3162301 ccaggtacag aagcggtgcc ggctgtgacg cagacgccgt tacaacaatt gtataatcaa 3162361 gcgcgccgtg tttacgcaat gtttctacta cgccgcggac tgttgattct ttttggccga 3162421 tcgcaacata tacacagatc atgtcttggt ctttttggtt caggatcgca tcgatcgcaa 3162481 cagatgtttt acctgtttga cggtcaccga tgatcagctc acgctggccg cggccgattg 3162541 gaatcagtgc atcgatcgct ttgataccgg tttgaagcgg ttcatgaacg gatttacggt 3162601 ccataacgcc tggtgcaggg ctttcgatcg gacgagtttt gcttgtcaga atcgggccta 3162661 gtccgtcaac cggctggcct agcgggttta caatacggcc gattaactct tcaccaacag 3162721 gaacctccat gatgcggcct gttcttttta cttcgtctcc ctcacggatc tcactgaaag 3162781 gtcctaagat gacgatacct acgtttgatt cctcaaggtt ttgagccata cccaaaacac 3162841 cgtttgaaaa ttcgacaagt tcaccggcca tacagttgtc aaggccgtgc acacgtgcaa 3162901 taccgtcacc gacttggatg actgtaccta cgtcttgaac ttcaatatca gattgataat 3162961 tttgtatttg ctgttttatc agcgtgctaa tctcttcagc tttgatgctc acttaggttt 3163021 caccccttct atcgattttc cccggctaat tgacgttcaa tgcgctgaag cttcccgctt 3163081 acgctgccgt cataaatccg gtttccaatg cggactttaa taccgcctat taaatccgtc 3163141 tgcacttcat ttctgattct cagtgaagcg actccggctt tttttgcaaa cacttgtgat 3163201 aatggtaaca tttctgcatc cgtcagcggt ttcactgaat atacgattgc gtcttctgtt 3163261 tgacgggcca catttgcgag tttgataaac tcatctgtga gctcagggac aatcgcggca 3163321 cgatggcggt caatcaaaag aaaaatcgta ttgagtacgg actgtgacaa agagccaaat 3163381 gcattttgaa tcagctcttt tttcttcgca gccggcacct tcggatggtt caacacatca 3163441 ttaagcgctt tttcattttg aaatacttgt tttacaacaa ttagctcttc ttctacttga 3163501 ttcagctgag cggactcatt ggctatatca aaaagagctg atgcatatcg tttagagaca 3163561 gctgatccac tcatcggctt tctcctacct ctttaagata gtcctggatc aatttctctt 3163621 gcgcttgttc atccagttct ttttcgatca ctttcgacgc aatcatgaca gaaagagacg 3163681 ctacttgctc acggagagca gaaaccgcct gttccttttc cttcacgatt tcagttcttg 3163741 ctgcttcttt cagacgttca gattctgcac gtgcagcctg aataatctct tctttttgct 3163801 tctctcccag tttctttgcg ttttcgataa gagtttggga ttcctgtctt gcttctttta 3163861 aaagaacgcg ctgctcttca atcagctgct gcgcttcttt atttttttct tcagcagacg 3163921 taatttctcc agcgatgtgg tcttcacgct gtttcattat gtttaatagc ggccctaaag 3163981 cgtatttctt cagaagcgct aataagatta acatagctaa cagttggaac aggatatctc 3164041 cgccgttaaa cgacaatcct agttcaagtg gtaattgaga catctactac ggcaactccc 3164101 ttctgcaggt ttttctttgc tgatccagca gccgcacttg tctcttttca gccggcaagg 3164161 cgggatgctt atcagacata aagcaatggc gaaggttctc ttggaatgat cttcgccatt 3164221 tttagttcat ataaggcttt tatgcttagc caaagaacgc taagaatgcg ataacgacag 3164281 cgataatagg aagggcttca actaatgcga tacccatgaa cataagagtt ctcagttctt 3164341 tacctgcttc cggctgacgg gcaatcccct ctaccgtacg tgaaacaatc aaaccgttac 3164401 caatacctgc accaagtgcg cctaaaccaa ttgcaatcgc agctgctatt aaattcatga 3164461 aaaagttcct cctttaaaat gttatccgtt tggatataat gttttaatga tcatgactga 3164521 ttttatgaga catgtacacc atcgtcagca ttgtaaagat aaatgcctgg atagcaccaa 3164581 taaataaact gaatgcttgc catgccagca tcggcagaat ggcaccgatt gtaccgacaa 3164641 gaccgagagc cacgctttgc gaataatggc ttgttgctaa tcccgcaagc aggccgagaa 3164701 gaatctcacc ggcgaagatg ttaccataca gccgcaaacc tagagtcagc gtattcgcaa 3164761 actcttcgat gattttcatc gggagcatga atggaacagg tcttaaatag tctttggaat 3164821 attccttgag ccctttcatc ttcacaccat agtagtgggt taaagcaaca accatcacgg 3164881 ctagcgttaa tgtaatggca ggatcggctg tcggagactt ccaccagagc tcatgtccga 3164941 ttgtaataga gaacggcagc cccagcatat tcgacacaaa tatgtacatc agcaatgtga 3165001 caccaagtgc caagaagtta gcccctgttt ttaaatccat tgtactgcca ataatattgc 3165061 ggacgaaatc aacaatccat tccataaagt tctgggcttt tccgggacgg atcgaaagcg 3165121 ttcttgtcgt caatatagca atcaataaaa caatcacact cgccacagta atcatcagaa 3165181 tgtttgtcag attaaaagta agacctagaa attctatagt tctgtaacca tgattcaaag 3165241 ggttttcacc tctcttccat tgatgaacgt ttaagctgga taaaggaatc tatcataatg 3165301 acagggtata ttgtcattaa tccaataact gtacttgcca tatgaaagta ttcgggattt 3165361 ttataggcaa cagccacagc aagaatcgca ttgcaccacc gcgctgcgct cccgagagat 3165421 cgtatggact ttcctttctc tacagctctg tcaaaagcat tcattcttct gacgagcagt 3165481 aaaaaattaa acaaactgaa aacagttccc agaataaggc ctaaaaaaac ggttttatac 3165541 gctgttaaac cataacccag tacatacact gccaaaatga acaataaata tttgcgttgt 3165601 ctgctaaatg taagcttggg atcgtccatc aattatctgt ctcctgatga aaaaataatg 3165661 tatagcttgg atacggcaaa aatcagcggt taacccttag tagaagacct tttttgaccg 3165721 gcaaaacggg cctgttcgaa aaaatcattc atccgcaagc cttgcaggga tgctgtttca 3165781 ttcgcttaaa taaatcctca taatacgggt ttgctgagag gatttacatt gaggatgagg 3165841 actataatga aagctatgaa aaccttctca taataccctc gtttagcata caatagcccc 3165901 taacatgtgt caatctgttt aaagttaaaa aactttttat actttacgtc tccacagaat 3165961 gttcacattt tcacctataa ttgtatacag attcaccgaa tagcaaaaaa ctggataaaa 3166021 aaatgaaacc cccttttggg gatttcattt tttattttgt tccaaacatg cggtcacccg 3166081 catctccgag acctggaaca atatatcctt tttcatttaa tttttcatct agcgccgcaa 3166141 tgtaaatatc aacgtccgaa tgatgcttct gcaattcttc cacaccctcc ggcgctgcta 3166201 caagacacat gaaacggata tttttcgcac cgcgtttttt aaggctgtga atggcttcaa 3166261 ctgcggaacc gcctgtagcg agcatcgggt caaccacgat gaattcacgc tcttccacat 3166321 cagaaggaag cttgacatag tattccacgg gttttaaggt ttctggatca cggtaaaggc 3166381 cgacatgtcc cacttttgcc gcaggaatca gctttaaaat gccgtcaacc attcccaatc 3166441 ctgctctgag gataggaacc actccgagtt ttttccctga gatgactttc gatttcgcag 3166501 cctgaaccgg tgtattgata tccacttctt ccagaggaag atcgcgggta atttcaaatg 3166561 ccatgagtgt agccacttca tctactaact ctctaaaatc cttcgtacct gtattttcat 3166621 tccgtatata tgtcagcttg tgctgaatta aaggatgatc aaatacataa acctttccca 3166681 tactgtgttt cagctccttt tttattgtcc catcaacaat tacacacttc tattgattct 3166741 acaaaaaaag acattgagtt tcaagaacat cgtcaaaaaa cccgccgggc ataagcccaa 3166801 gcgggtttta ggatcttaat aatctaattc tttatataaa ggaaatttat cagtcagagc 3166861 agctacacgc tgtcttgctt cttcaagttt tccttcatct tcgtggtttt tcaatgcaag 3166921 cgcaatgata gcaccgactt cttctaatgc gtctccgtca aaaccgcggc tggttacagc 3166981 agctgtacca agacggatgc cgcttgttac gaaaggtttt tcaggatcat atggaatcgc 3167041 gtttttgtta gacgtaatac caatttcatc aagtacatgc tccgcaacct taccagtcag 3167101 tccgagcgaa cgaaggtcaa caaggataag gtggttgtct gttccgcctg aaacgagctg 3167161 gatgccctct ttcgttaagg cttcagccag acgtttcgcg tttgaaatga cgttttgtgc 3167221 atatgttttg aaatcgtcct gcaatacttc accgaatgaa acagcttttg cggcaataac 3167281 gtgcatcaga gggccgcctt gaattccagg gaagatcgat ttatcaattt tcttgccaaa 3167341 ctcttcacgg caaaggatca taccgccgcg aggaccgcga agtgttttat gtgttgttgt 3167401 tgtaacgaaa tcagcgtaag gaaccgggtt tggatgaagg cctgccgcaa caagtcctgc 3167461 gatatgtgcc atatccacca tgaagtaagc gccgacttca tcagcaattt cacggaattt 3167521 cttaaagtcg attgtacgag gatacgcact tgctcctgct acgataagct tcggtttatg 3167581 agcgagggct ttttcacgca cgtcatcgta atcaatatat tgagtttctt tatctacgcc 3167641 gtactcaaca aagttatatt gaacaccgct gaagttgact gggcttccgt gtgttaaatg 3167701 gccgccgtgg gagaggttca tcccaagtac agtatcgcct tgctccaaaa tcgtgaagta 3167761 cactgccatg tttgcttgtg cgcctgaatg aggctgaacg tttacatgct ccgctccaaa 3167821 gatttccttc gcgcggtcac gggcgatatc ttcaacgaca tcgacgtgct cgcatccgcc 3167881 gtagtagcgt ttgcccggat atccttctgc gtacttattt gtcaaaacag atccttgtgc 3167941 ttccataacc gcttcactta caaagttctc agaagcaatc aattcgatct tagtctgttg 3168001 gcgttcacgc tcatttttaa tggcgttaaa cacttgttcg tcttgcgcag gtaaatgttt 3168061 catcagcgag atcctctcct atccgtatcc tgttctttgt ttttaccatc actattgtac 3168121 atggttttta aggccgatgt aaaagattat ttttaaaaaa tctaaatttt tattggtaaa 3168181 aacgaatatt aataacttaa atttaattta aagttcggaa tttatttcac tatcttaaaa 3168241 taaaagaaaa gactggctat gcagtccttt cattcgcact cataaaccgc ccgcactccg 3168301 ccgattagtt tcggccgtgt acgcgccaat gtcacatgag ctgaaccgag gctgttttga 3168361 gagacacgca cagggacagc caccggtttc agatgcatgc cgataaacgt atcgcctata 3168421 tcaattccgg cgtcagcctg aatggtttca acaagaacag gagacttcat ctgcttaaac 3168481 gcataagacg ccatcgctcc gcccgctttt ggaacgggca cggcagaaac ggttggaagc 3168541 ctgaacagct tggctgtttc tgcttcgacg acaagcgctc tgtttaaatg ctcgcagcat 3168601 tgaaacgcca gatggattcc cgttttttcc cggagctcag caagtccgct gtagatgctt 3168661 tcagcgatat ctacactgcc cgatgtgccg atccggctgc cggccacttc gctcgtgctg 3168721 catccaagga cgaagagctg atcttgtttc aattccgctt ggtcctgaaa ctcagacagc 3168781 atcgtcttcc acgtttgttt caactcattc attaaacagc acccctacag gtttttctct 3168841 tcataatcgg agatttttcc aatacgcgtt tggtgtcttc ccccggtaaa ctcagtagtc 3168901 agccagattt ttgcgatttc ccgagccaaa ccaggtccga tcacccgttc acccatcgca 3168961 aggatgtttg tgtcattatg ctccctcgtc gccttcgcgc tgaaggtatc gtgcgccagc 3169021 gcgcagcgaa tcccttttac tttattagcg gaaatgctca tgccgatgcc tgtcccgcaa 3169081 attaaaatgc ctctgtcaac ttcgccgcta accacttttt cggccaccgg aaaagcataa 3169141 tccggataat cgacagagcc gctgccgcag tcacagccca tatcaatata ttcaatttgc 3169201 aattcgtcca ttaactcttt gatttcattt cgaatgtgaa cgccgccatg atccgatgca 3169261 atggctactt tcatctgctt ttcctcccag cgtgtgtgat gcggcccgcc cgctttattg 3169321 accgcgcagc ctgtccgctc tttgattcac accatatgat gtgcttttca ctatattcta 3169381 ctccttcacg caggatttgc aaatgacctg tttgcagatt ttctgacaac ttatctacgg 3169441 tcttttttca gctgttttgc cagctgccga agaagctctt caagctcatc tcgcgtttgt 3169501 ttatagatgt caattgagcc gccgaacgga tcgaggacat caccatggct gcctgtgaca 3169561 tattctttta acgtaaacac tttatcacga taacgtccaa attggctggc aatgatctgt 3169621 ttgtgctgat gggtcatagc cagaaccaaa tcagccgatt ccataagttc ttcagttaat 3169681 ggagaagaca catgattaag ggcaatgtgt ttttcaaaca gcgcttcgac tgcatgaggc 3169741 gtcgctttcc cattaggtga agcaaacacg cctgccgagc ggacattgac attcagccct 3169801 tccctttctg caattgattt aaaaagcgcc tcagccattg ggctgcggca cgtatttcca 3169861 gtacagacaa aaataatatc catgtcagtc accccttatt tttctctatt atatatgaag 3169921 aaaaaagaaa cggcgacttc gtttctttta ttggtatatt aaattggcaa aagcagcttt 3169981 aatccaaaca cgattaatat gatgcccccg agcgcttcgc tgtatgtgcc aagccatgac 3170041 tgcacttgtt ttccgaccag caggcccagc catgtcaaca tcatgctgaa cagcccgaac 3170101 agggtaattg tgaggagcgg atgcgagccg tatatcccca agctcaagcc gacggaaaag 3170161 ctgtcaaggc tgacgccgat ggcaaacagc aataagcccg gccctgccgg tgacatgaat 3170221 cgttcttctg actgtttaaa agaggccata agcatttgaa ccccaagaac aaaaagcagc 3170281 gccccaccga tataaaccgc taacacgccg aggagccctg acagcatgtt accggccgcc 3170341 atccctgcga gaggcatgat gacgtgaaag aggccgatga tgaaaccaat atagaatatc 3170401 tgcttctttc taagtttgac catgcccatt ccaaggccga cagaaaaagc atccatccct 3170461 aaagcaaacg ccatgatgct taatgtaatc agttcgccta taaacaaatc cgacatacat 3170521 aaataacccc cttggacacg ccccgctttt ttagcctatg cgtgtccaaa aagggttaga 3170581 acatctgact gctttcagcg aatcactctt cctccggcgg ctttcatcag cctgttcata 3170641 atagcaagac cgacacctgt atccggaaag gattccgcta taatgaaatc caccttattc 3170701 tcatcaaagc tgcgcaaagc atcatacagc cctgccgcaa cagtctcaag ctgagcccgt 3170761 cttccgcagc tcttcacata atcagcggaa taaacgcccg ctttttcttc tgtcgtcagg 3170821 acaccgaccc gtcttccacc ctgttgatat tcttgaatga ggtgctgaat gcgctctggg 3170881 ctgccttcgc aaatggcaag aggcgctgtc ggcgcataat gtgtatattt catccctgga 3170941 gaaatcggct tctcgttttg gtcgctgagc cctttatcca catggatcgg cccgatcacc 3171001 gcttcaattt gttccttcgt aatgccgcca ggacgcaaga gaacagggat gtcgtccgca 3171061 catgaaagca cagttgattc gaccccgatt ccggtagggc ctccatccac aataccggct 3171121 atgcggccat ccaagtcgtg agccacatgc tccgcttttg tgggacttgg cttgcctgat 3171181 agattggcgc tcggtgctgc aatcggcagt cccgattcgc gaatcaatgc aagggcaagc 3171241 ggatgatccg gcattctaat ggcaaccgtt tcaagacctg ccgttacacg aggtgaaagc 3171301 gcatcaggtt tgcaaggcag aatgagcgta agtgctcccg gccaaaaccg tttcatcaat 3171361 gttttcgcct tttccggcgc cgggcccgtt aaatcctcaa gctggctgat atccgcaatg 3171421 tggacaatca ggggattatc gctcggccgc cctttcgcct catatatttt tttgacggca 3171481 tccgtatttt ttgcgtttgc gcctaggcca tatactgttt ctgtcggaaa ggcaacgacc 3171541 tcattttctc ggagcaaagc ggctgcttgt gcaatttgtg gatcatttgt ggataactcg 3171601 tcagttacat ccacaaacca tcttttcgtt ttcatttctg accaaactcc ttattcacaa 3171661 caataaaacg attgttttac gcgtgtaatc cttttgaaag tataaaagat gtcctgtaat 3171721 aaaacaagcg ttatccacaa attgtggaca acgctaataa agaagtggat aagtatgtgt 3171781 ataaactgca cttatccaga cgcttttttc atcaaaacgg ctccttctgt ttgccgcgat 3171841 tcacagaagt gatcagaaga aaacagctcc tccggtacac tctcagctct ttcaaaaccc 3171901 atggccgtca gaaagtccgc agaggaatgc tgatttgcta ctaggtacac ggttttgatc 3171961 tgatgctttt cgcacagcac ctccatgctt tgaaaaagcg tgacgatgtg gccttggtga 3172021 agcttgtccg atatgacaag tgatcgcagc agcccctggt cacagcttat tttttcaata 3172081 ccgaggcatc cggcaatgtt tttctcactg tcctccagca taagaaattg agtgaagcct 3172141 tctttcacgc cttcatagct ggtttttgcc tgttttaaaa atgcctcgag cacatctccg 3172201 tctttttccc ttgccacccg cagttgataa aacatccgtt caccccgttt ttgcgttctt 3172261 tcttccaatc tatgaggcaa atctattttt agaccagatg attaggaaaa aaggtcggaa 3172321 atccattcga ctaaaaagaa tttcacttct gtgccgtctt ctttttcttc gttctcttct 3172381 tttttggctt tttccgcttt agcggttacg tcctcaagca ctttttcagt ctgctttttt 3172441 gaggcttctt tatcttcttg ttctttgacg gcttccccgt tagaaaaatc aagaaagcag 3172501 aggggcggga acagcacaca ccaccagttg gcgccgtctc cgtttccaag cgtaatcaaa 3172561 atcgcttcat actcaccagc gggatatacc atgttgccgt aaagctttgt cggaaacgag 3172621 attttgtcaa aatcaacgga tatcgactga ttcgctcctt ctttctccat tgtttccttt 3172681 gcaattgctt tgatttcagg cagctttgaa cgaatcacgc gacgcgcttc ttcaatagaa 3172741 gtaatatcct ttacccaagt tgtgatttct ttattcaccg cgtctcttat atgacgtttt 3172801 aattgctggt cttgatcact atcgctgttt gccagtattc tcaaacgaat cgcctgatca 3172861 ggtatgacca ccggctgatt ttccgatttt tgtgccgtct cttcttttgc cagccctacg 3172921 agcgctccgg ataataaaag aaagatatat atacaaatga ttactgtttt tttcatcggt 3172981 ccccaccgtt cctctccgtg ctttgtttct agccctatta tggacaagga gagcctggga 3173041 taaacgtgca gggtgaaaaa aatctagcaa gctgttaatc ttatttatgg tacgatagtg 3173101 ttttaggagg tttaagatga aatacaatta tacagtgctg ttatcagcat tcacgatgtc 3173161 cgttctttat tcagtaattt atattcattc atttatcatt gccgctctca tcacaatggc 3173221 attttatttt ctgtttcctt atttgatctt cgcactgccg cttcaaatca tgatgaataa 3173281 aaagccgaaa cgtttcagcc ctttgtatct gctgtattac cttgccgctg cttttattgc 3173341 caacgcgatc attttcggca tgcttcagcc ttcgggacaa tctctgtttc aaaatacagc 3173401 cttttatctt ttcgctgtat taacagctct tatctattgg atatgggatt ctgttttact 3173461 gcaaaaaaag gaagcctaag aggcttcctt ttttattaaa acaaaatcgt cagtaaataa 3173521 catagaatgg aaggtatcgc cgcaacaaag aaagcggccg ccattttcat gcgagatgta 3173581 cggccttctt tggtttctga atggtagttt gcccgctgat cgcttccgct tacagccaaa 3173641 cccgatgtaa tgatcgcgag ccccactaaa acgagagacg caacgccaaa aatcgcttca 3173701 tatgaaagag cctgcggaaa aatggtgcca atcatgctct caatcgcaat gagcaggatt 3173761 cctgctgtca gggccttttt catgtttaca tcccctttgc tggtgttaaa cagcttgatc 3173821 cattcactcg ccagcaagct gcttatttat ttttatgaat cagagcgcat atggttctgt 3173881 cttttccatt aatatctttc agcacttcca cttccgcccc cttaaacgcc ttgaggatca 3173941 ggtctttgac cgccgctccc tgtttccagc cgatttcaaa aacgacaaat actttatcct 3174001 tcataacaag cggaatgtct tccataaacc gcttataaaa tttcagcccg tctccgccat 3174061 cggtgagtgc gtgcagcggc tcatgaaaac ggacaatttc cgataaatca gccatttctt 3174121 cctctgaaat atatggcggg tttgagacaa tgatatccgc tttttttccc gccttaataa 3174181 aaggctcaag cagatcgccc tgataaaagc gcacattcgc tccgagtttt tctgcattgg 3174241 cagaggcgac ttgcagcgcc tctttcgaaa tatcgaccgc cgacacagaa aagctttggt 3174301 tttcaagcgc aagcgtgacg gctattgcgc cgctccctgt accaacgtca acaacttcga 3174361 gcttgccgtc ttcagaaaaa acactccgat atttttcaag caaatgaaag acaacttctt 3174421 cagtttccgg ccgcgggatc agcacatcat cattcaccat aaattcccgt ccataaaaaa 3174481 actcttttcc tataatgtat tgaaccggca cgccctcttt atgcatctca acgtgacgct 3174541 taaagcgata cagttcgtct tcaccaatcg gttcctgtaa gcttgcgagc agcttgcttc 3174601 tctccattcc ggtatcataa agcaatagga gctcggccgc attttcttct cttcccgctt 3174661 cggttaaata agaagaagcc catttcaggg cttcgaatat cgtcttcatc ttaaccttcc 3174721 gactgctgaa gcttgcttgc ctgatcttca acaatcagcg cttcaaccac ttcgtcaagt 3174781 tttccttcaa gaatctgatc aagcttttga atcgtcaaac cgattctgtg atccgtcaca 3174841 cggttttgcg ggaagttgta tgtgcggata cgttcagagc ggtcaccaga tccgactgct 3174901 gatttccgtg tttgatcata ttcagcctgg gcttcctgct gaaatttatc atagattctg 3174961 gcacggagaa ccttcattgc tttttctttg ttcttaattt gagatttttc atcctggcat 3175021 gatacaacaa cacctgtcgg caagtgagtc agacgaaccg cagacattgt tgtgttaacg 3175081 ctttgtccgc ccggtccgct tgaagcaaat gtatcgacac ggatatcctt ctcatggatg 3175141 tcgacctcta cctcttctgc ctcaggaaga catgccactg ttgcagtgga tgtatggatg 3175201 cgtccgcctg attctgtttc cggaacacgc tgtacgcggt gggcgccgtt ttcatatttg 3175261 agtttagaat acgcgccgct tcctgtaatc ataaagatga tctctttgta gccgcccgtt 3175321 ccggttacat tcgcttccat gacctctgtt ttccagccct gaagctcagc ataacgggaa 3175381 tacattctgt acagattgcc cgcgaataaa gcggcttcct cgcctcccgc agccccgcgg 3175441 atctccatga taacgttttt gtcgtcatta ggatctttcg ggatcaggag caccttcagc 3175501 cgttctgaca gtgtttccgt ttccttctga agttcagaaa tctcttcctt caccatgtcg 3175561 cgcatctcag catccagctt ctcttcaagc atcgcttttg catcagccag ctgttctgac 3175621 gcatctctgt attgtctata tacgtcaact gtttcttgta tatcagattg ctcttttgaa 3175681 tattctctta gctttttcgg atcgttgact acttctggat cgctcaaaag ctcatttaat 3175741 ttctcgtatc gttcttcaat tgattttaaa cggtctaaca cggtcttcac ctctgttttc 3175801 ctgtgcgtaa cattctcatt atagtatagt gattaacccc agtcaaaagc atttcaatcc 3175861 cagctggaaa agctccctct gctatactgg aattcgagga gggatgatgt tgctgaaatc 3175921 catacatcat attgcaatca tatgttcaga ttacgaaaag tcgaaagctt tctacgtaca 3175981 taagcttggt tttcaggtga ttcaagaaac gtaccgcgaa gagcgcggct cctataagct 3176041 tgatttgtcg cttaacggct cgtatgtcat tgagctgttc tcgtttcccg atccgcccga 3176101 acgacaaacc cggcctgaag ccgcaggcct gcgccacctc gcctttacag tcggcagctt 3176161 ggataaagct gttcaagagc ttcatgaaaa aggaatcgaa acagagccaa tcagaacaga 3176221 tccgctgacc ggcaagcgtt tcaccttctt ttttgatcct gaccagcttc cattagaact 3176281 gtatgaacaa taacagtttt tgaagaaaaa aaggagatac ccactttctt tgccgaatct 3176341 tttcttgttt tgtctaacgg gaagggaacc gcattctatg gtcgaatacc tagcttaaaa 3176401 ggaggtatgg gatcatgaat acaaatatgg tagcaagtga actcggcgtc tccgcaaaga 3176461 cggtgcagcg gtgggtgaag cagctgaatc ttccggccga acgcaatgag ctcggacact 3176521 attcgttcac ggcagaagac gtgaaggttc taaaatccgt tcaaaaacaa atctctgaag 3176581 gcacggcgat tcaggatatt catctgccga aaagcgctaa aaagcgcaca ggcttccttg 3176641 tccaaaaaac aagtagcgac acagaacgaa gaatcgagca gcttgaacaa aagctggaca 3176701 cccttttaca gcaaaggcag gacgaaagcg aattgatggc aaggatgtcg gaactggaac 3176761 gccagctgaa acaaaaagcc gatgaaggtg tatcttacca gctgcttcag caccgcagag 3176821 aaatcgatga tattcttgca gatctgcaat cactgacctc acaaatgaaa gaattcaccg 3176881 ctcattcgat ccccgagact gctgctgctt ctgaaaaaac caaaacaaga aaaaaaccgc 3176941 tgctgtcact gttcaaattt caaacctaaa gcaaaaagct cccttaaagg gagctttttt 3177001 tgttacgcag taagcgcgat aatgattgga agtgaaatca atgacagaat cgcactgacc 3177061 acaaacgcag ttgcagtttc ttcttcttgt ttctcgaaac gagtcgcaat catggctgca 3177121 acggcagaac cagggaatgc aacaagaagg attgcttttg ttgtttggtc agctggaagt 3177181 ccgatagcaa gagcaatcag gaacattaac gcaggctgaa ccgcaacttt tagtaacgca 3177241 ataccgatag ccggcatact gagtttaatt ttacgaatac caacggtaac accaacagcg 3177301 aagagagcaa caccagatgt tgtgcttcca agctgatcaa gcattttaac acccagctca 3177361 ggaagagtga aattgaaaac cagcaccaag atcatactga ttaacggagc agctgcaagc 3177421 ggctcacaaa gaccatgcag gattgatttt cctgtcatct tccagaagct gtcgccactc 3177481 tcttcgtttt tcttagaaga ctcaccaaca gtagcgataa tgatcgcgag cggatcaaga 3177541 atcgcgttaa ccacgatacc tgtgaccgcg atcggaatcg caacttcatt cgctccgaat 3177601 aagcttccca ataccgggat acccataaat gcgaatgtcg gctgtgcaga gttcaaagaa 3177661 aatacagatg agttcgttaa atcatacttg aatataaatc tgcaaaccaa aagaatgatg 3177721 atatagaaac caacaatccc aataattaaa gaaatcatta aaggtacttg tgataaaaat 3177781 tcacttctgg aagttgtcaa aataccagcg ataaagtgag ctggaagtgc gtatttcgtt 3177841 actaacgtac ttaccccttt tgccgacttg gcatcataac ttccaaaatg tcctgcaaac 3177901 caacccagca cgataacaaa gaagatcggc gccaggagga ttaagatatc taagatgctc 3177961 aaaatattct cctccaaatc ctatgtccgt atactttagc tttacaaaaa gctttccctc 3178021 ggacagaaaa atttactcgc taattatttc gcgatgactt ttttgtattc aggtgtccac 3178081 attgcatcaa gtaccgcttg tttcacatct tcaggctgac gatttgccac gccgtcttta 3178141 attgctgctt cagcaacggc aatcgcaact tggatagaaa cctcttgaag cttatcaatg 3178201 cttggaagca atcctgctcc aggtgtttca agatcaacca tttcagcaat cgcatcagca 3178261 gttgcagcaa acatagcagg tgtaatgata cgcgcttcag ctacaattga accaagtcca 3178321 agaccaggga acgcgaatgc gttgttagat tgtccgattt cataagaaac accgttgtat 3178381 tctacattgt caaatgggct tcctgttgca ataagcactt ttccgtcagt ccatttgaac 3178441 agatcttcag gaacagcttc agcaaggtga gtcgggttag acatcggcat gataaccgga 3178501 cggtctacgt gagatgccat ttcttttaca atttcctctg tgaatgcacc tgaaacccct 3178561 gaagtaccaa tcaagattgt tggtttcgct tgacgaacaa cttcatcgaa tggaatttga 3178621 cctttttcat cgcgcttcca gtctttcact tcatccgcat tgcgaaggta aggtttttgg 3178681 aaatcaagga tgccttcgat gtcttcagtc agcaagcctc tgtaatcaag tgtgtagaaa 3178741 cgtttgttag cttcttcttc agataatccg gctagcacca ttgtgtcacg gatttggtca 3178801 gcaataccga taccagcaga accagcaccg aagataacaa cacgctgatc tttaatagaa 3178861 gcgccggttt tcttcatagc ggcaagcaca cctgcaagtg taatcgcgcc agtaccttga 3178921 atatcatcat taaatgtcag gatttcatga ttgtattttt tcatgatgtt gcgtgcattt 3178981 ttgttgccaa ggtcttccca gtgaagaagc gctttaggga agaatttcaa tgcagctttt 3179041 acataagcgt caatgaaagc ttcgtagcgt tcaccttgaa cacgttcatg cttgttacca 3179101 atatataaag gatcgtttag aagtttttcg ttgttcgtac cgacatcaag cacaaccggg 3179161 ataacacggc tagggtcaat accagctgca gcagtgtaga cagccaattt accgattgca 3179221 atattaatac cgcctacacc ccagtcaccg ataccgagaa tgctttcgga gtcagtagca 3179281 acgataagat caatatcgcc tgctgtcgca tgaaggtttt caaacgcttt ttcaataccg 3179341 tcaatgttat cgattgacaa gtagattcct tgaggtcttc tatattcatg gctgtattcc 3179401 tgaatcgctt caccaactgt tggcgtgtac acaacaggaa gcatttcgcg aagatggttt 3179461 ttcagcaatt tatagaaaag aacttcgtta cggtttgcaa gatcacttaa gtaaacattt 3179521 tgacgaaggc ggtcaggctg cgcttggaat tgctcgtacg cgcgttgtgc ttgttgatca 3179581 agagaaagta cagttggcgg cagaagccct tctaagccga gttcttgtct ttcttctagt 3179641 gaaaaagcaa cgcctttatt taaagtagga atagataaaa cttcttttcc tctaagagtt 3179701 gtttctaagt ggccttcttt cgtttttttt atgttattca agcaaatctc cttctttctt 3179761 gaaatagtta accaagttaa gtaataaccc atctaaaata tgaccgatca tgatctttat 3179821 gcgactttgt gacaattatt cgaacaatgt ctcaaaacta tttacattac gtaagctatt 3179881 gtatgcctgt caaaatcaaa attcaagaga agaaaattac ttaatttttt aatatactta 3179941 tttaaatttt ttaattgaat attatcagaa tataaaaaaa acaccggtgt ttttagccgg 3180001 tgcattctat ctttataccc atgttttgga ctatttttta gatttacctg ggacttcgtg 3180061 atgatgtctg catcttgctt catatgattc agctgcacca accaaaatga ccggatcatc 3180121 gtaagaagca ggtttgccgt caatgaggcg ctgtgttctg ctcgccggtg atccgcaaac 3180181 agaacagacg gcttgcagct ttgtcacact ttccgcaatc gccatgatat tcgggacgac 3180241 accgaacggc tctcccctaa aatccatatc aaggcctgct gctatcacac ggtagccttt 3180301 atcggcaaga gatgataaaa cctcaacaat ttcctgatca aaaaactgca cttcatcaac 3180361 cgcaaccaca tctgtacttt cactgatgtg atcccaaatg tccgcagcag acgaaatggc 3180421 atagctcgtc atcgatgttc cattatggga gacaacagca gcttcgctgt atcggttatc 3180481 aattacaggc ttaaataccc tgacttcctg cttggcataa gttgctctct tcactcttct 3180541 gatcagctct tcagatttcc ccgagaacat gctgccgcaa atcagctcaa gccacccgct 3180601 ttgtttcatt atgtacatag gcttcgctcc cctctctctg ccagctgtgt tttagacaat 3180661 ataaaaaaca ggcaagactg ctgcttgcct gttgagaaat ctattattac ttaagaccgt 3180721 attttttgtt aaagcgatca acacgaccat cagcagaagc gaatttttga cggccagtgt 3180781 agaatgggtg gcattcagag caaatctcaa cgcgtacctc ttcttttact gagcctgttt 3180841 caaattcatt tccgcaagcg catttaactg ttgctttttt gaaattagga tgaattcctg 3180901 ctttcattgt atccatctcc ttccgccctg aatcccgtgt ggaaacagag ttattatttc 3180961 ggagcattgt ccgaaacgca tatgagaaaa ttatatcagt gatttacttc ttttgcaaat 3181021 acaatttacc ttcttgcaga tgatagattt gcctgtttcc attcttgatt gagaatatcg 3181081 aaaaattcct ggtttgtttt ggtttttttc atttttctca tgaacttttc tgcgaaatca 3181141 ggtgaatcag acatcgtttt gcggatagac cataaacgat caagatgctc tttaggcaca 3181201 agcagctctt ctttgcgcgt tcctgaacgg cggatatcga tggcagggaa gatgcggcgc 3181261 tcggcaagag agcggtcaag atggagctcc atgttgcctg ttcccttgaa ttcttcataa 3181321 atgacatcat ccatacgtga acctgtatcg accagagccg tagcaaggat ggttaagctg 3181381 ccgccctctt cgatatttct cgcagcccca aagaagcgtt tcggacggtg gaacgccgct 3181441 gggtcaatcc ccccggaaag cgttcttcca cttggcggaa tcactaagtt gtaggcgcgg 3181501 gcaagacgtg tgatgctgtc catcaggata atgacgtctt ttttgtgttc cacgagacgc 3181561 atcgcacgtt caagcacaag ctcggccact ttgatatggt tttccggcac ttcatcaaac 3181621 gttgagctga cgacatcccc agctacagag cgctcgatat cggttacttc ctcaggtctt 3181681 tcgtcaatta aaagcacgat cagctctgct tcaggctggt tcgctgtaat gctgttggca 3181741 atttccttca gcaacatcgt ttttccggct ttcggcggcg caacaatcaa tccgcgctgc 3181801 ccaaatccaa ccggcgccat catgtccata attcttgtag acaagaagtt cggctttgtt 3181861 tcaagcacca tttgacgatc cggataaagt ggcgtaagag ccgggaaatg cacacgctct 3181921 tttgcagatt cgggatcatc cccatttact gcttcaacgt gcaaaagtcc atagtaacgc 3181981 tcattttctt ttggcgggcg aaccttgcca gatactttgt ctccgttccg caaatcgaaa 3182041 cggcggattt gtgaagctga gatgtaaatg tcttctgagc ttggagagta gttgatcggt 3182101 ctcaggaatc cgaaaccttc agactggatg atctcgagaa cgccttccat aaacagcaga 3182161 tcttcctgtt ctgcattcgc tttcagaatg gcgaaaatga gttctttttt tgtcagtttg 3182221 ctgtaatagg agattttata atgtcttgca agttcataaa gctctttcaa tttcatattt 3182281 tccaaagagg aaatagatac gtctttcata aaaacaccac gcttttcata gtcaatatct 3182341 tactctgaac atgtcatctg ctgcttttgc acaacatccg ccaaagcaca ttcttttttt 3182401 aacataaagg aacttctatc ggtaacactt ccacccatga tcggcgcttt tgttaaaagg 3182461 attgtcttaa tgagttttga aggaagcgag gacaaaaaca tgagaagatc aatacttata 3182521 tcgtctgtat gcggtagaaa ttgaaacttt cctagtgctt aaaagaaggt attacgcagt 3182581 aaaattcgca gcactcttta tttttacctt atttcaaaaa attattcaac tgaaataagg 3182641 ttttgacacg gaattgatag agttgacgct tttctgcaaa agttaaagcg ggctcacacc 3182701 cgctttttct gtttgttatg gacggattac aagatttggt ttctttttca agctgtgtct 3182761 gccgtcaacg aaacgaacag tgcccgattt tgcacggata actaagcttt cagttgtacc 3182821 gacagagcct ttgaattgaa ctccttttaa cagctcgccg tcagtaaccc ctgtagctgc 3182881 aaaaatcgcg tcatcaccct tcacaaggtc ttccatgcga agcactttgc ttaaatcaag 3182941 gcccattttg tgacagcgag tgatttcttc ttcgctttgc ggaagaagtt taccaatgat 3183001 ttctccgccg agtgctttta gcgcaacagc ggaaagcaca ccctcaggag cgccgcctga 3183061 tccgaacagg atatcaacgc ccgtgtggtc gaaagccgtg ttgatggcgc ctgcgacatc 3183121 gccgtcattg atcaatttga ttctggcgcc ggcctcacga agctcggaaa tgatttttgc 3183181 gtgtctttca cggtttaaaa ttgtggcaac gacgtcctca acgtccttgt ttttcgcttt 3183241 tgccaccgct ttaaggttgt caatgacagg tgcttcgatg tcaatgcagc ccaccgcttc 3183301 cggaccgact gcgatttttt gcatatacat gtcaggagca ttcagaagcg tgccatggtc 3183361 tgcgaccgcg ataaccgtca gcgcgttcca gccgccgctt gctaagatgt ttgtgccttc 3183421 aagagggtca actgcgacat caacgcgagg gccgtacccg tttccgagtt tttccccgat 3183481 atacagcatt ggcgcttcgt ccatttcccc ttcaccgatt acaacggtcc ctttcatcgg 3183541 cactgtatca aaaacgtctc tcattgcact tgttgccgct tcatcagcct catctttttt 3183601 tccccggccc atccatcttg ctgatgccaa tgccgcagct tctgtcacac gtaccaattc 3183661 cattgataaa cttctttcca tttcaacacg atctcctctc acaagaaacc attatgaatt 3183721 ttgaagctgt tctatttctt cgtcagtcat tctttcacgc caaattgtcg ctccaagccc 3183781 ctcaagcttc ttctcaaggc tgctgtatcc tcggtcaata tgctccagtc ccgtaatttc 3183841 cgtgacgcca tcagccatca gtccggctac caccaagcag gctccggcac gcagatcact 3183901 cgccttcact tttgcgcctt gaagctcgac aggacctgtg atgatggcag atctgccttc 3183961 tactttcata ttggcaccca ttcgtctcag ctcatcaatg tgcttgaatc ttgccgagta 3184021 gatggtgtct gtgacgacac tcgtcccttt cgcccttgtc aggagcgccg tcatcggctg 3184081 ctgtaaatca gtcggaaacc ccgggtatac gagggttttg acgtcaaccg gctttaagtt 3184141 cttctgcccg ccgacaatga ggagctggtc gtcgcttgtt tcgatatgat agcccatttc 3184201 tctcagcttt gccgttaacg actcaagatg agtagggatg acgttatcga taatgacttc 3184261 cttgcccatt gcagcccctg caatcataaa tgtcccggct tcaattctgt ccggaatgat 3184321 cgtatgcttg cagccgtgca gttccttcac gccgtcgatt cgaatcacat tggtgcccgc 3184381 acctttgatt ttggcgccca tgctggtaag caatgtcgcg acgtcaatga tctcaggctc 3184441 cttggcagcg ttttcgatga tcgttttccc ttctgccaaa acagcggcga gcataatgtt 3184501 aatcgttgcc ccaacgctta cgacatctaa ataaatccgt gcgcctctca gcctttcagc 3184561 tcgcaaataa atggcgcctt gttcattggt tacttcagct ccgagtgctt caaagccttt 3184621 gatatgctga tcaatcggac ggggccctaa gtgacagccg ccaggcaatc caatgaccgc 3184681 ctgcttgaag cggccgagca tcgcccccat taaataatat gacgcgcgaa gcttttttac 3184741 tttcccgtta ggaagcggca tgctgatcat cgacgtaggg tcaacaacca tttccccatt 3184801 ctcaaaatgc acgttgccgc cgatttcctt taacaggtca cgcagcgttt caatatctga 3184861 aatctctgga agcccttcaa ttgtcacctc ggaatttgcc aaaatggttg caggtattaa 3184921 cgcaacagcg ctgtttttag cgccgctgat atgtactgta ccgtttaacg agtcaccgcc 3184981 ggcaatattc aacttttcca tgatagtctc cttccataag aagatagctg cggagctaaa 3185041 taaaatgtca ttttattctg tctctgcaaa taaagctcat gtccaaaatc tagccaattc 3185101 gaagagaaag aatacaacac attgtaaaat atcaggaaga aaatagcgaa gctttggggg 3185161 gtacaggttt caaaagatgc acagagaccc gccggctcga gagacatcgt cgtcatccgg 3185221 caaaagcagt acgcataccc ttcattccga tatcagcttc tgcagcccaa tgattccttc 3185281 tctgtaaagc ggcgtcagca tctgaagatc cgctgtatca ggtcggtgaa atacaaaggc 3185341 cgcggcaaac aggcataaag ctgtttgccg cccctttcat tatttgttcc agtctgccag 3185401 gaattgttcg attcctttgt ctgttaacgg gtgtttagtg agcgcatgaa tgactttcag 3185461 cggcattgtg ccgatatgag cccctctaag agcagcttct gtcacgtgct gcggatggcg 3185521 gattgacgct gcaatgattt gcgtgtcaag gccgtgaatg tcaaaaatct gtttaacttc 3185581 tgaaatcagg tcaagcccgt tgtggccgat gtcatctaaa cgtcccagga atggagatac 3185641 atatgttgcc cccgctctgg cagcaagaag cgcctggttg gcattgaaga tcaatgtaac 3185701 gtttgttttg atgcctaagt cagtaagtgc tcttaccgct tttaaaccgt cagacgtcat 3185761 tgggattttc accgtaatgt tcggagcgat cttcgccagt tcttttcctt cctcgatcat 3185821 ttcctcagct ttcaaagaaa taacctctgc gcttacagac cctttcacga cgtctgtgat 3185881 ctcgcgaaga cggtcgtgga atgatacgtt agcttccttt gctactaaac taggattcgt 3185941 cgttacaccg gcgagaattc ctaattcatt cgcttctcta atttcatcga tattggctgt 3186001 atcaacaaag aataacattt tcaaaaagcc tccctgatta agaaattttc tgaactgcga 3186061 atatgattgc gctttctaaa gatagacgga aaaccgcctg tcaagctgtc aggcggctat 3186121 aaaaagttcc aattgaatta agcttggttt gaagaaccaa attcacgcat tttaccgata 3186181 actgtttctt tgatcgcttc acgagctggt ccaaggtatt tacgtggatc gtactcgtca 3186241 ggcttagctg ccaatgtttc gcgaacagct tttgcagaag aaatttggtt ttcagtattc 3186301 acgttgattt tagctgtacc aagtgaaatt gattttttga tgtcagcagt cggaattcca 3186361 gtaccgccgt gaagaactag cggaaggcca gttgattttc cgatctcttc catttctttg 3186421 aagccaaggt ttggctcacc tttgtaaggg ccgtgaacag aacctaatgc aggtgcaagg 3186481 cagtcgatgc cagtgcgctc aacaagctct tggcactctt taggatcagc gtagattacg 3186541 ccttcagcga taacgtcatc ttcttgtccg cctactgttc caagctcagc ttctacagat 3186601 actccgtgga aatgagcaag ctcaacaact ttagcagttg ttgctacgtt ttcttcaaat 3186661 ggatggtgag aagcgtcgat cattacagat gtgaaacctg catgaatcgc tttcgcacaa 3186721 gattcaaagc ttgaaccgtg gtctaagtga atcgcaacag gaactgtcac tttgtactct 3186781 tccataagtg cttttaccat agcaacgact gttttgaagc cgcccatgta gcgtcccgca 3186841 ccttcggaaa caccaaggat cactggagat ttttcttctt cagctgcttg taaaatcgct 3186901 tgagtaaact caaggttgtt taagttaaat tgtcctacag cgtacccttt ttctttagct 3186961 gtattcaaca tttccgtcat agaaactaaa ggcatgtcga atgtcctcct tatgtagcct 3187021 gattgtcttc tagcgaaaaa agctttccac cctagcatga cccatatatt gctgtcatat 3187081 gtaaatactc agatcgcttt ttctccataa ctaggatacc aacttttcga caaatcggca 3187141 acataatgac atgattcatt tgtttcttct ttttgtcagt tagacttcag gggcagatat 3187201 tttttgacgg cgtctctgat ttcgtcgatg tcaaacggct tggcaaagtg cgtcagagcg 3187261 cccaattcct tcgattcctg gatcatgtcg agctctccgt atgccgtcat gataatgacc 3187321 cggatgtttt cgtcaatgac cttcatccgt tttaagattt cgattccgtc catgccggga 3187381 attttcatgt ccaacagcac aaggtcgggc cgttcttttg tcacaatgtc aagcgcctgc 3187441 aggccgttcg cagcctgaaa cgtctggtag ccttctttat tgaacacttc atttagcaaa 3187501 atacgaatgc cgtattgatc atcaacgatt aaaatttttt cattcatcat tttacacccc 3187561 aatattatga ttttcgtcaa aagtaagcag tattgtatgt attctgtttg attttcctat 3187621 ttcctttaat tataatagtc tactttacga cattttctga gcattttctc ttttgttgta 3187681 tactgatatt gtacgttata aaggaggatt cacttatgtt gaaaatattc acgacgcagt 3187741 taacaggtat tttttcccgc attcaggata aggaatctga cgcgattgaa gatggggcgc 3187801 ggctgcttgc tcaagcggtg atcagcgggc attccattta tttatacgga gcgaatgagc 3187861 ttcagggcgt cttttatgag gccaccgaaa gcaaagaacc cttcccatct gtcaaagcct 3187921 ttccagaaaa cgctgaggaa gtgacagaaa gcgacagggt gctgatgttt tgctcaggga 3187981 cgggcacagc cgaagaacag gagctcgcaa aagagcttta tgaaaaaggt gcgggagtcg 3188041 tatgcgtatc gcccgcagcc aaagacagtg cgggaataga acagtattgt gatgtgcata 3188101 ttgattctaa attaaaaatg ccgcttgttc ccgatgaaga cggcacccgt tacgggtttc 3188161 cctctttaat gacagcactg tatgtctatc acgctttatc gtttacacta aaagaaattc 3188221 tgcaagagta tgcataatat cttattgtac atgctggaac ttgccggaaa caaataaaaa 3188281 agacttgccc gcttttgaca aacggcaagt cttttttatt acttctgatt tgcagcttcg 3188341 acagacgctc cgataaagcc tttgaataga ggctgaggtc ttgtcggtct tgacttgaac 3188401 tctgggtgga actgagaagc cacgaaccaa gggtggtctt tcagctcgat gatttcaaca 3188461 aggcgtccat cagggcttgt gcctgagaat acgaagcctt gctcttccat ttgctgtctg 3188521 aattcattgt taaactcata gcggtggcgg tggcgctcgt acaccacttc atcctgatac 3188581 acttcaaagg ctttcgtgcc ttcttcaagc ttacaagggt aaaggccgag acgaagcgtt 3188641 cccccaagat cctcaacatc cttttgttca ggaagaagat caatgatcgg gtattgagtt 3188701 gacggatcaa tttccgctga gtgagcgcct tttaagccca atacgtttcg tgcgtattca 3188761 atagacgcca cctgcatgcc caagcaaatg cccaagaacg gaatgttgtt ttcgcgcgcg 3188821 tattttgtcg cgacgatttt cccttcaaca ccgcggtctc cgaatccgcc cggcacaatg 3188881 atgccgtctg ttccgcttgt gagttctgcg atattgtttt ctgtcacttc ttccgcgttg 3188941 atccacttca cttttacatc tgtgtcaaac gcatagcccg catggcggag agactcgaca 3189001 acagaaatgt atgcgtcagg aagctcaacg tatttgccga caaggccgat tgtaatcgtt 3189061 tgagacaggt tgctgacttt gttaacaagc tctttccact cggacatttc cgcttctttg 3189121 catgccaatt tcatgtgctc gcaaacaagc ttatcaagcc cttgtttttg aagctccagc 3189181 ggaatggagt aaaggttgtc cgcatcttca cattcaataa ccgcttttgt atcgatgtcg 3189241 cagaaaagcg cgattttatc tttcatatct tgagaaatcg gcatttctgt acgaacgacg 3189301 atgatgtttg gctgaatgcc caagctgcgc aattctttta cgctgtgctg tgtcggtttt 3189361 gtttttaatt cgccagcagc tttaatgtaa ggcacgagcg tacagtggat gtacattacg 3189421 ttttcacggc cgatgtcgct cttcatttgg cggatcgctt caaggaatgg cagtgattcg 3189481 atgtctccga cagtaccgcc gatttctgta atgacaacat ctgcgtttgt ctctttccct 3189541 gcgcggtaaa cacggtcttt caattcgttt gtgatgtgcg gaatgacctg tacggttcct 3189601 ccaaggtaat ctccgcggcg ttctttttta agaactgttg aatagatttt acctgttgtc 3189661 acgttgctga atttattcag gttaatgtcg ataaaacgct catagtgacc aaggtccaag 3189721 tctgtttcag cgccgtcatc cgttacgaat acttcaccgt gctggtacgg gctcattgtt 3189781 cccgggtcaa cgttgatgta tggatcgaat ttttgaatcg tcacgttcag tccgcggttt 3189841 ttcagcaaac gccctaatga agctgctaca ataccctttc caagtgagga tacaactccc 3189901 ccggttacaa aaatatattt cgtcatttcg tttgctcctc tcttcgctct tagctacatt 3189961 tttaaaatgt actattttat aaaaaatcat ttagcctttt aaatgattta taagaaaaat 3190021 gaggggtgaa aataagaaag ctccctttca atttcttgaa agggagcata acgtactatg 3190081 ttctctcttc gtttttgaag agcccaaaat acatactaca tagttcgact atgaaagtca 3190141 agatcgtttt gaagatgaaa tctgatacta tttaatttcc tcttcttcat catcatagtc 3190201 ttcatcatct tcatcaataa tatcttcttc gatctcaaga tcatcgtcgt cttcatcaag 3190261 atcttcttcg tcaaaatcgt cggcttcaag atcgagttct tcctcaactt catccaaatc 3190321 aaggtcgtct tcgtcgatct cttcaaactc gtcaagatca agatcttctt cgactgcttt 3190381 cttcgctttt ttctttttcg ccttgactgt cggctgagtt tcttcatcaa gctgatcata 3190441 aggataccag ctgcgaagcc cccacgtctg gtcagaaagc gccaggaagc ggccgtcaat 3190501 gtttaaatct gtataaaatt gagcaatgcg gtctccaagc tcttcttttt tcacgccgag 3190561 caaagatgcg atttcattta aaagctcctg aaaaggaact ggttttttat gttcttcaaa 3190621 taattcgtga gcgatttcaa ctaaagccat ttcctttagc tcttcctgtg aatattgttt 3190681 gatacccaag gtcggacact ccctttctat tacttatatg tatctgtttt atcaataatg 3190741 aaagcgattt tgtatcgttc ttatacaaac catacctctc attataaaca aaataaaaca 3190801 gaatatgcta cccttaacag cgttaattta aataatttta caagagtgat ccgactgaga 3190861 gatgttttcc gttaatccgc gagcattctg gagatgacca gtctttgaat ttcttgagtg 3190921 ccttcataga tttgcgtgat ttttgcatca cgcatatagc gttctaccgg ataatctttt 3190981 gtatagccgt agccgccgaa aatctgcacg gcttcggtcg ttaccttcat cgccgtatcc 3191041 ccagccatca gtttggacat ggcggaagct tttccatatg gaaggcccga tgattctaac 3191101 catgcagcct gataggtcag tagccttgaa gcttctatca ttgtcgccat atccgcgagt 3191161 ttaaaagcga tgccctgctg ctcggcgatc gattttccga attgctttcg ctcttttgca 3191221 tattgaagcg ccgcatcaag cgctccttgg gcgatgccta cagcttgtgc agctatgccg 3191281 tttctgcctc cgtcaagcgt cttcatcgcg attttgaagc cttctccttc ttctccgaga 3191341 cgctttgatg cgggcactac acaatcttcg aacatgattt ccgttgtcgg tgaagaacgg 3191401 atgcccagct tcttttcttt cttgcctgta aaaaatcctt caaaatcctt ttctactata 3191461 aaagcggtaa cgcctttttt ctttttctcg ggatcggtga cggcaaaaac aatgtaaata 3191521 tcagcaacgc cgccgtttgt gataaacact ttggaaccat ttaacacata gtcatcgccg 3191581 attcgttcag cagttgtttt catgctgccg gcgtcagagc cagaccctgc ttcggtcaaa 3191641 gcgaatgcgc cgattttctc tccgagagcc agctgtgtta agtactctgt cttctgttcc 3191701 tctgtcccaa aggcaaacag cggccagctg caaagagaga tatgggcgga aagcgtcaca 3191761 ccggtggagg cgcacacttt tgacagctct tccaccgcga tgacgtaggc taaatagtca 3191821 cttccaattc cgccgtaatc ttcaggccat ggaattcccg tcaggcccag atttgccatt 3191881 tcccgaaaca gctcgcgatc gaagcgttct tgttcgtccc gttcagccgc tgtcggggcc 3191941 acctcatgct tcgcaaaatc gcgcaccaat tttcgtatca tctcatgttc ttctgataat 3192001 gaaaaattca ttgcttctcc cccattttca gatcagcgcc taaaacggat tgagccagaa 3192061 gctcgacgac gtcgtacgtt ttgacttggt cttcggcttc cttcgccttt gtgccgtccc 3192121 caagcatcgt gagacaatac ggacagccag aactgatcac cgatgggttg actgcgagcg 3192181 cttgctctgt cctggcgacg ttaatcctgt tgcctgtttc ttcctccatc cacattaatc 3192241 ccccgccggc tccgcagcac atgccggttt cccggcttct ctccatttca acaagctgca 3192301 cgcccggaat ggctttcaaa atctctctcg gcggatcata gacttcattg taccggccca 3192361 aatagcacga atcatggaag gtaatcgtct catgaagcgg gtgctgcggt cttaattttc 3192421 cgtttttcac aagctcggcc agcacttctg tatgatgata aacctcgcct tcaaatccga 3192481 aatccggata ttcgttttta aataaattgt atgcatgggg atcgatcgta acgatttttt 3192541 tgacatcatt tttttcaaat tcagaaatat tcttctcagc cagctcttgg aacaaaaatt 3192601 catttccgag gcggcgcggc gtgtctcctg aatttttttc tttattgccg agaatcgcga 3192661 aggacacgcc cgcgtgattg agcagcttgg caaaggaaat tgcgattttc tggcttctgt 3192721 tgtcgtaaga ccccatggag cctacccaga aaaggtactc aaattctttt ccttcttttt 3192781 tcatttcttt tacagtcgga atctcagcat ccggcgcctc gtcacgccaa ttttcacgtt 3192841 ccttgcggtt gagtccccac ggattccctt gccgctcaat acttgtcatt gcgcgctggg 3192901 cgtcactgtc catttttcct tctgtcagta cgaggtagcg gcggaggtcg atgattttat 3192961 ccacgtgctc attcatgacc gggcattgat cctcacagtt ccggcaagtg gtgcatgccc 3193021 aaatttcttc ctctgtgatg acgtcgccga tcaagcttgg attgtaatca agcgccgctg 3193081 cggcttcctg cgatccgctg cccgctgacg ccgcagccag ctgattgcct ctcgtatgcc 3193141 gaaacgctgc tgcgggcacc catggggagc gcgaggtgac ggcagcgcct ttttccgtga 3193201 gatggtctct gagacgcaaa atcaagtcca tcggagaaag catttttccg gtgcctgttg 3193261 caggacacat attggtacag cggccgcact cgacacacgc gtatagatca agcagctgag 3193321 actgtctgaa atcctcaatt tttcccgctc cgtagctttc tttcgtttcg tcggtaaaat 3193381 caattttttc aagttttccg gcagattcca ttcgattgaa aaagacgttt gccgggccgg 3193441 cgattaaatg ggcatgcttt gactgaggca cgtacactaa aaagctaagc aagaatagga 3193501 gatggatcca ccatgcgata tagaaaatca ccgccgcgcc tgttttcccg acaccgctaa 3193561 gcataaacgc aatacctgag gcaattggct cgctccaaga aagcccatgc tcatgccaaa 3193621 tcagattcat cccgttccca agcagaacgg tcagcattaa tcctccgata aaaatgagaa 3193681 cgagtccggc tttgaaaccg cgtttcagcc tcacgagctt ttcgatataa cgtctgtaga 3193741 atgcccaccc aacagcaatt aaaatgagaa acgtaacaat ttcctgaaaa aaggtgaagg 3193801 cgggatagac cgggccaagc gacagattcc ggccgggagc cagtcctttg atgataaagt 3193861 caattgctcc gaactgaacc aatataaatc cgtagaaaaa catgacgtga atgattccgc 3193921 ttttcttgtc cttgagcagt tttttctgtc cgaatacatt cacccatatg gcgtgaagcc 3193981 gttccttgaa ccgttgatca aattgttctt tctggccgag cttgatgtag gccagtctcg 3194041 ttttgaccaa gtaaacaaac aaatagacag cgtaagcggt tacaatcaga aataataatg 3194101 catttgcgat gagaaagccg ctcattccaa ttcccccttt ttactgataa agaccgcgat 3194161 cccctacccc cgaatctgta taagattatc tttatgataa ataatgaatg agtgttcagt 3194221 caataattaa attcctgctg ttcgggcaca ctacctttac tacggaaagg agtgccggta 3194281 tgaaggtatt tatcgtgatt atgatcattg tcgttatttt ctttgccttg attctgcttg 3194341 atatcttcat gggccgtgcc ggatacagaa aaaaggcgta cgagcctgtt ttttcaaaaa 3194401 agaagagtga catcgaattg atccactgcg gcgctgatct cgttgagcgg atgatgaatg 3194461 atattcgcca ggccgcctct tctgttcaca tgatgttttt tattatgaaa aatgatgagg 3194521 tcagccacaa tatgtatacc ttgctgaaaa caaaagccca agctggcgta tccgtttatt 3194581 tgcttctgga ttgggcgggc tgccgggcaa ttaaaaaaac ggcgcttcag acgatgaaaa 3194641 atgccggcgt ccatgtccat gtgatgaatc gtccccgttt tccttttttc ttttttcaca 3194701 tgcaaaaacg gaatcaccgg aagattacgg tgatagacgg aaaaatcggt tatatcggcg 3194761 ggtttaatat cgccgaagaa tatcttggaa agaaggcgaa gttcggcaat tgggaggatt 3194821 atcatctgcg catgatcgga gaaggcgtac atgatcttca aacgcttttt gcttctgatc 3194881 taaaacgaaa taccggaatc gaactgggtt cggatgtttg gccaaagctt cagcaaggga 3194941 ctatttctca caagatctat gcgaccgacg gttattccct tgaaaacata tacttggcca 3195001 acattgccca agcgaagaat cgccttacgg tttgcacgcc ttattacatt ccatcaaaac 3195061 cgcttcaaga ggcccttatt aacgcaagaa aaaacggcgt atccgtgaga atcattgtac 3195121 cgatgaaatc agaccatccg ctggtacgag aagcggcttt tacgtattat tcggagctct 3195181 tggatgccgg ctgtcttatt tatcgttatt atcaagggtt ttatcatgta aaagccctca 3195241 tcatagacga ccatctcagc attatcggaa cagccaactt cgataaacgg agcctgttct 3195301 taaatgaaga ggtgaatgtt gaaattgatg acgaagcgtt tacaagtgaa gtctatgcca 3195361 caattgagga ggatatgaaa aagtcggagc tgctgacgat ggaggatttc agcaagcgca 3195421 cattcaggca gcgcccggcg gaatggctcg gcagggcatt atcttatttc ttataaagga 3195481 gagttcctat gattttcaga ttcgggttcg tttcaaatgc gatgagcctt tgggatgcgt 3195541 ctcccgctaa aacattgaca ttcgcgcgtt attcaaagct ttcaaagact gaaagaaaag 3195601 aagcgcttct gactgtgaca aaagccaatt tgcgcaatac gatgagaacc cttcactata 3195661 tcatcggcca cggcattcct ttgtaccgtt tttccagttc gattgtgccg ctggctacgc 3195721 atcccgacgt gatgtgggat tttgtaacac cgtttcaaaa agagtttcgg gagattggag 3195781 agcttgttaa aacccatcaa ctgcgaacaa gctttcatcc aaatcaattc actctgttta 3195841 cgagcccgaa ggaatccgtc acaaaaaatg cggtaacaga tatggcgtat cactaccgca 3195901 tgcttgaggc catgggcatt gctgatcgct ccgttatcaa cattcatatt ggcggcgctt 3195961 acggaaataa agacaccgcc actgcacaat ttcatcaaaa tataaaacag ctgccgcagg 3196021 agatcaaaga gcggatgaca cttgaaaatg atgataaaac atatacaacg gaagaaacgc 3196081 ttcaggtctg tgagcaggag gatgttccgt ttgtctttga ctttcatcat ttttacgcca 3196141 atccagacga tcacgccgac ctgaatgtag cactgccccg catgatcaaa acgtgggagc 3196201 ggatcggcct tcagccaaag gttcacttgt cttccccaaa atcggagcaa gcgatacgca 3196261 gccacgccga ttatgttgac gccaactttt tgctgccact gttggaacgc tttaggcaat 3196321 ggggaactaa tattgatttc atgattgaag caaagcagaa agacaaggcg cttctccgct 3196381 tgatggatga attaagctcc atccgcggtg tcaaacgcat cgggggcggt gcgctgcaat 3196441 ggaagtcata aatgtgcaaa aataggttta cgacttgtca gctttgggaa cttaggctat 3196501 ataagacaac aatcgatgga ggagaaagat catgaaaaat atcaagtctc tgaaagtagc 3196561 cgcacaggcc tttactttaa gaaatttgat tcatctttat aaaatgtgcc attccggaag 3196621 ccacgaggtt tatatttatt caaagaaaac gatgtgcaaa atcaaaagct taattgagct 3196681 tgaaacgttc cgcatggctc ataatgaaaa ggaatatctg atcgtagttg aaggaacaaa 3196741 agcatcacag ctcattgaaa aattccaaaa tctcatcgag cctgctgaga gagaagcgct 3196801 ctaacttaca tacaaaaaag gatagacatc tgtctatcct ttttcttatg ctcttacata 3196861 atggagctga accgcttgtc caaattgttt tgtccctttt aaccgcagtt ttgtttcatt 3196921 tgttagttcg tgaaacagcg ggatgccgct tcctaaaacg acgggaataa cagtgatgat 3196981 gaattcgtcg atggcatctt ctttcataaa gtcattcaca agctctgccc cgccagctat 3197041 ccagatgttt gagccttttt cctgtttcaa acgggcagtg aaggctctgg ctccctcatt 3197101 gataaacgtc acatgttcat cttgataact gtcgggcgat cctgtaaaaa catagcaggt 3197161 tttatcctga tacgggaaaa ccggtgttag cactttaacg tgctcatatg tgctccgccc 3197221 taaaatgact gtatcaacag tctgataaaa atcactgtag ccgttgtcac cttcaccttc 3197281 aaattcatcc agccaatcga tgcttccatc ttcttttgcg atcatcccgt ccaatgaaac 3197341 agcaatgtac agcacagttt ttctttccat gttctcctcc tatcgatgca ccatttgccc 3197401 gaattgcgct tgatgcagcc tgctgtatag gcctccggct tcgatcaggt cttgatgacg 3197461 gccttgttct tcaataccgt tgtttgtgac gactacaatt ctgtccgcgt ctttgattgt 3197521 tgccagcctg tgggcgatga caagcgtcgt gcgcccctca gacaactctt gaagcgcctt 3197581 ttggatcgcc gcttccgtct ctgtatcaag ggctgaggtg gcttcgtcga gaatcaagat 3197641 cgacggattt ttcaagaaca tccttgcaat tgacagacgc tgtttttgcc cgccggaaag 3197701 cttcacgccg cgttcgccaa tcatagtatc caacccatcg ggcatgttat ggacgagctc 3197761 ttccagatgc gcctgcttca cagcttgcca aatgtcttct tctgatgcgc ctagtcggcc 3197821 gtaggcgata ttttctctaa gcgtgcccga gaataagaaa acgtcctgct gcacgacgcc 3197881 aatctgcccg cgcaacgaag aaagcgtcat gtcttttata ctgatgccgt caatcgtaat 3197941 gtcgccctcc gatgcttcat aaaaacgcgg aagcagactg caaagcgttg atttcccagc 3198001 acctgacgga ccgacgaacg ccaccgtttc ccccgcttga atggataggt tgatgtcatt 3198061 gaggacattg tgatggtcat catagccaaa cgaaacatgt ttatagcgga tattgccctt 3198121 caggccggaa acatctttcg aatcaggtga gtcctgaata tccggctctg tctccatgag 3198181 ctccatatag cttttgaaac ccgcgatccc cctcggatac atttcgataa tggcattaat 3198241 tttgtcaata ggcctgaaca gcacattcgt caagagtaca aacgccacaa attccccgta 3198301 cgataaggag ccgcgaatga caaaccacgt cccgcacaaa aggacaaaca gcgtgacaaa 3198361 ccgggtcagc atatagctga ttgaaccgtt tttcgccatg attttgtagg aagaaagctt 3198421 tgtgacacga aaacgctggt tgttgacggc gaagcgttct ttttcaaatg cttcatttcc 3198481 gaacgcctgc acaagccgga tgccgccgat gttattttct acacgcgcgc tgaagtctcc 3198541 gatatccttg ttcagcgtgg taaatgcttt ggtcattttt ttgttgaaat aaagcgctag 3198601 ccaaatgacg atcggcataa tgataaacgt taataaagca agctgccagt taataaacag 3198661 catcactccg aacgccccga gaatggtcat gaccgcaatg aataagtctt ccggtccgtg 3198721 atgggcgact tcaccgatat acattaaatc gttcgtgagc ttcgacatca gcgttcccgt 3198781 cttgttgttg tcgtaaaatt tgaacgagag cttttgcaaa tggtcaaaaa gcgactttct 3198841 catatcagtc tcaatattga taccaagcat gtgtccccag taggtcacga tatactgaag 3198901 agccgagctg agcgcgtaca ccgcaaataa cccgattgag gtcgcgatga tcagtcccca 3198961 gtccctgccc ggcagcaagg tatcaataaa ataattgacg atcaaaggaa aactcagctc 3199021 cattaaacct cccgcgatcg ctgagaaaaa gtcgagaaag aacaacgttt tatatggttt 3199081 ataatatgaa aaaaattgcc gcagcaccct atcttccccc aatgtataaa taactgataa 3199141 tatttctcaa ttatactata cacgggctgt tttgtaagat cagatttctt ttttcttaca 3199201 gaacacctga aaacaggcgg gcaaacgact cttttgtccg gtcagccaca cctcttttat 3199261 aaaagccgac agggctgagc ttttcacttt cctgcatatc ctcttcaaaa tgggcctcaa 3199321 gggttcggat cgcttcggca tccgtgaaga acacattcac ttcaaagttg agctgaaagc 3199381 tgcgcatgtc catattcgcg gtaccgacgg aggcgagatc gccatcaatg atcatgactt 3199441 tttgatgcat gaagcctttt tggtaggagt acacttcaat gccctcaagg agcagctccg 3199501 ggaaatagga cctcgacgcg tattgggtca aaaagctgtc gttcttctcc ggcaccataa 3199561 cccttacctc tacccccttt gtcgccgctg cttttagcgc cgtgcgaatg gattcattgg 3199621 ggacaaaata gggcgtggcg atccatattg atttctgcgc tgaagaaatc atttcataat 3199681 aaaggtcgct catgctttcc ttcatgtcag ggcctgtcgc gacaatttga taaatgcctc 3199741 ctccttccac gggaaccggg gtattgtact cctcttgatc aattagcact tcattggaga 3199801 catattccca atccagcata aagatagcgt ggagcgtttg cacaatttcc ccctcaagcc 3199861 gcaggtgtgt atctctccaa aatccgatgt acggatctct gctgatatat tccttcccga 3199921 catttaatcc acccacaaaa ccggttttcc catcgatgat cacgattttc cggtgatttc 3199981 tgaaattcag cttctggttg aaaaacccgt atttcagcgg agaaaacggg acgatgtcca 3200041 cccccgcttg tttcattctc ataatatctc ttcttgccag cttcatgctt cctgccgcat 3200101 cgtataaaaa cctcacctcg acaccctggc gcgctttctc catcataata tccatcatgc 3200161 cgcgtccgag catgtctgat ttaaacatgt agtattcaat atgtatgtaa gattccgctt 3200221 ttctcattgc tttgaaaatg tccgggaagg tttcttcgcc gtttttcagc actttgatgt 3200281 tgcttttcgt attgatattc atatgggcag ccctgatgga atatgtaaag aacctctctt 3200341 gattgtcctt cagccctgtc acttcgggcg tttcctcctt gtcaaacagc ttcctgagct 3200401 tttccctgtt gtacattcgt tttgtcttaa acagctttcc ctttacataa agctgtcccg 3200461 aaaacagata aaacacgtag ccgacgattg gaaaaaagac aagaatatgg atccatagca 3200521 gcgtgtgctg cgaggtgcgg ttttcaagaa ttaatgaata gatgctgaac aaaataatgc 3200581 ttatatagca aagcaatcct ccgtaaaact caagtctgga aaccggaaaa aaccaaatga 3200641 catatgcccc gatgagcatc atatataaaa agaaaaattc cagtctcctt ttcagcatcc 3200701 tgattctctc caatctgatt caattacctc tgtattacct cttttttcta atcgataaac 3200761 cttgtaagta aaaaacctct ccgccaaagg aggagaggtt tagagaaaac taactgtcac 3200821 ggaattcatc cgcatcgttt ctgcagaaat aaagcaagac tattggcaac gccgagtgac 3200881 aacatgagcg gcaagctgaa cccgctcagc actccggcaa gcgccgaaaa gaaggcggcg 3200941 ctgtgactgc aaatacggtg gatagagtaa atttgatacc cattctgatg agagaaaata 3201001 tataaaacgg gaaattgatc agaaagatat aaggagttag tcaggctgaa tcataatctg 3201061 gctgttccgc cggtttaaaa tgagtaaaat ccttgatgtt atttccatat acaaacataa 3201121 caggattccc ggcagcccag ccattacctt ggcagaaaaa accccctctt gcaaggggga 3201181 ttttcacgag cgtttccgat atacaacgta gctgcgggtc agatacttga gcggcagact 3201241 gaacacatga accaatctcg taaacggcca caggataaaa acgacgtatc ctatcacaat 3201301 atgaaactta aaccatagcg ggacactctc catcaaagag gcgtcaggcc tgaacaaaac 3201361 gatttccctg aaccagggcc cgactgtggt ccggtaatca aatcctttcg aatcaatgtt 3201421 gagaaacgtg gccgcaacgc ctgacagcat catgaacagc agcaggagga gcgtaaggat 3201481 atcggatggc gagctcgttt tgcggattct tttgtcaaac agccttctgt acgtcaggat 3201541 gacaagtccg gtacatgccg caatgcccgc cggcaagcca gcgccaatcg ccattttgtg 3201601 atacatatgc tctgaaatgc caagggaagc atacacgcct tctgggatca gaatccccat 3201661 gacatgcccg ccgacaacgc acagcagtcc ccagtgaaaa agtgtgctgc cagccgcaag 3201721 ttttttcttt tctaacagct cgcttgattt cgccgtccag ccaaattggt catgctgata 3201781 gcggtaaata tggccgccga taaagattgt caatacaatg tatggcataa taccccagag 3201841 gatctgcccg ctcatgcctg aacagcccct tcaacgcttt cacgtacgcc aatgttttca 3201901 agcgcggcca gcagcacgtg cagcagttca gcgtatatac tgtcattttt ttcgagacgg 3201961 gatgccagct ccctcacatt ggacagatat ttctcaaaca cgcttctcgc tgcttcaatt 3202021 tctgcagccg cagcaaattc cagcatcagc ggcagataat caggcagctc tttctctgtc 3202081 ggcaggaaac cggattgctc gtatgtgttt tttaaatgca gcaattcaat gccgcgttcc 3202141 ctttgctcgc ctgagttaaa gtaggtgaca tacatatttg tttttttccc gaagtcgaat 3202201 gtatagacat agtgttcaat cagcgcttcc ggagaatagc tggctgacgt ctcgaaaaag 3202261 tgcagcagct tctcccggat ttgccggttg ccgatttctt ggataagagc cttccaatcg 3202321 ggaagctcgg ctctccactc ttcatccgga taagagagaa gacaggaaag agcagagaac 3202381 gtgatttgcc ggtctgtggt gttcatcttg ttacacctca tttatcaaaa gttagaaaca 3202441 ggagccgggg ccgcctgaaa atgataagcc gcagcttcct tgttcagcgt ataaatctga 3202501 tacttcttct cgatggctgc tcggaatcac aaagcggtca tcatatttgg caatcgcaag 3202561 cagccgatac atatcttcaa tttgctgttc tgttaagccg acactggaga tcagttccgg 3202621 atcgattgat ttattcgtct ggaccgctct catatactgg cgcatgacag acattttctt 3202681 taatgttgac cgaatatgat ccgtatcacc ggctgttaac agctgcgcca aataatctat 3202741 cgggattctc atttggtcga tagccggaaa aatatcttcc gccgtttgcc ggctgccttt 3202801 tccttcaaag agattcataa tcgggctgag cggcggaatg taccacacca ttggcagcgt 3202861 gcggtactca ggatgaagcg gcagcgcgat cttccagtca atgatcattt tatagatcgg 3202921 tgattgctgc gcggcctcta tccattcagc cggaatgcct tgttcttttg ccagtttggc 3202981 aacctcagga tcattcggat caagaaaaac gtccaattgg gaatggtaga gatccttttc 3203041 attttcaaca gatgccgctt cctccacttt gtccgcgtca tatagcatga cgccgaggta 3203101 gcggattctg ccaacacacg tctcagagca gatggttggc agtcccgcct ccaaacgcgg 3203161 aaagcagagt gtgcattttt ccgctttgtt cgtttgccag ttaaaataga cttttttata 3203221 aggacaggat gagacgcaat atctccatga acggcatgcg ttttgatcca caagcacaat 3203281 gccgtcctcc tcgcgtttgt acatggcgcc ggatggacag gatgagacgc atgccgggtt 3203341 gatgcagtgc tcgcaaatac ggggcaaata catcataaag acgtcatcga attctgtttt 3203401 gatcgattcc tccatctttt gtacgttggg atcttcaagt cccgtaatgt ggccgcctgc 3203461 gagatcgtcc tcccagttcg gtccccattc gatattcatg aaatcccccg tcaaggacga 3203521 tttcgggcgt gctaccggct ggtgtttttt ctgcgggctg ttcgttaatg tttcataatc 3203581 atagttccaa ggttcatagt aatcatcaat tgacggctga ttcggattat agaaaaggcc 3203641 tgcaagccga ttggttttcg agcccgattt cagctcgagc tttccttttt tcaatgtcca 3203701 gccgccttta tatttgtcct ggtcctccca ttgcttcggg tagccgatgc ccggctttgt 3203761 ttctacatta ttgaagtaca tatattccgc accggaacgg tttgtccacg tgtttttgca 3203821 ggtgacgctg cacgtgtggc agccgatgca tttatccaag ttcatgacca taccgatttg 3203881 cgctttaatc ttcaagccaa tcgacctcct tcagcttgcg gatgacgacg ttcaggtcgc 3203941 gctgattccc cgttggaccg taataattaa agccgtagct gagctgggcg tagccaccga 3204001 tcatctgtgt cggcttgacg tgaatccttg tcgggctgtt atgggtgcct ccgcggttat 3204061 tcgtcagctt tgtgccgggc acgttgatgt ggcggtcctg ggcatggtgc ataaacgcca 3204121 ttcctttagg aatccgatga gacaaaacgg ctctcgcgac gacaacgccg tttcggttga 3204181 agcattcaat ccaatcgttg tctttgatat ccgtgtcctc tgcatcatct ttattcatcc 3204241 acacggtcgg cccgccgcgg aacagcgtca gcatcggcag agaatcaaaa tacatgctgt 3204301 ggacagacca tttattatgc ggcgtcaaat aattgaggac gatttctttt ccctcttgat 3204361 caggccgttt gctcagaaac gggcgatgct ggaggatcgg tttgaatgtc gccatcgttt 3204421 caccgaattc catcatcagt tcatgatcga cataatagga ttgtctgcct gtcagcgtcc 3204481 gccacggaat taatttttca acattcgttg taaacggcga atacctgcgc cctccttttt 3204541 cagagccggt aaacgctgga gacgtgatca ccgttttcgg ctgggctgta atttgttcga 3204601 acgtaaagca ttcttcctcg cgttcttccg ccaggtcttt cagcttcagg ttcgtgatgt 3204661 tttcaagtga ttcccatgct tttactgcga cctttccatt cgaagtggat gatagggtta 3204721 aaatcgcttc tgcagcctgc tttgcttcac ttatatttgg acatcccttt gccacgctgt 3204781 ccgaggtgat ttctcccagt ctctgtttga gtgattcata ttcatcggct attgaccagc 3204841 tcatcccttt tgttccgctc ggctttaaag caacgttcgg accaagtgca gtcattttat 3204901 gaaaaatgtg tttgtaatcc cgttcaacga cttggatgtt cggcatcgtt tttcccggaa 3204961 tggcttcaca ttcgcctttg ctccagtcat tgattttgcc gaatggctgg gccaattcct 3205021 gcatggtgtc gtggagcagc ggtgtcgcaa ccacttcttt caccggctcc atatcgactt 3205081 cttctgccag atcggaaacg gcttttgaca gcgccttgaa aatatcccag tctgacttcg 3205141 attcccacgg agccgagatc gcaggagcaa atggatgaat gaacggatgc atatctgtgc 3205201 tgctgagatc gtgtttttca taccatgtcg ccgccggcag cacgatatcg gaatacagcg 3205261 ccgtacccgc cattcgaaaa tcaagattga ttaataagtc gagctttcct tccggcgcct 3205321 gctcccgcca tttgatttct tctgggcgga tgctgtcgct gtcgtcattc attaaaccgt 3205381 tcgttgtccc cagcaaatgc ttgagaaaat attcatgccc ttttcctgag cttgagatca 3205441 gatttgcccg ccatacaaag agattccttg ggaaattcac ttcattgtca ggatcttcaa 3205501 tcgcgaattt cagttttttc tcttggagct gtgaggccac gtacgcacct acgtcttcag 3205561 gtgttgctgc ccctgctttt tcagcttctt tatacagatc gatgccattt tgattgaaag 3205621 tcgggtaaga cggaagccac cctagccgcg ccgccagcac attgtaatca gcgtggtgct 3205681 tgtagcggga tgaagcagca atcggtgatg ccaaatcact gatcggctgg tcctcataac 3205741 gccactgatc tgtcgcaaag tagaaaaatg aggtgccatt ttgcagcttg ggcacgcctt 3205801 cccagtcctt tgcagttgca atcgtctgcc acccttcagc aggtcggagc ttttcctgcc 3205861 ccacgtaatg ggcccagcct ccgccgttta cgccttgggc gcctacaagt aaaacaagat 3205921 ttaacactgc tcggtagatc gtgtcggagt tgaaccagtg gttaatgccg gcccctacga 3205981 taatcatgga ccggccgtct gtatcgatcg cattttgggc aaactctctg gcaatcttaa 3206041 cgacagcttc ttttttgatt cctgtcattt gttcctgcca ggcaggcgta aacggctcag 3206101 ggtcatcata ggagacagcc gatcgttcgc cgatgccccg gttcacgccg tagttagcca 3206161 gtatcaagtc aaacacggtc gtgatgtacg tttcttcacc gttcaggttc atttttttaa 3206221 taggaagatc ccgctcgagc actttgtttc cgtcatttga aaaatacggg atgcgcaccg 3206281 tgccgatttc gtcctctatt cccagcacag agagacgggg ttcaatcggt tccccggttt 3206341 cttcatcaat catgtgcagg ttccatttct gctgcccgtc ccagcgcgag cccattgtcc 3206401 cttggggtat ggcaaatgaa cttgtctgtt catcccaaac cgcaggcttc cactgatcat 3206461 gctttgtctt ccgcccgatg tccttcgcat gcagaaaccg tcccgctgtg tatacgccat 3206521 tttcttttga cagagtgacg agaaatggaa aatcagtgta ttgcttcgcg tactcaataa 3206581 aacgttcagt ttcttggttc acgtaaaatt cctgcagaat aacgtgaccc atcgccatcg 3206641 caagcgcccc gtcagtccct tggcgaatac tcagccagtc atccgcgaac tttgaggatt 3206701 ccgcaaaatc tggactgatc gaaatgacct tagcgccttt atagcgggcc tccgccaaaa 3206761 aatgcgcgtc aggcgttctc gttaacggaa cgttggagcc ccatgtgata atatagccgg 3206821 aattgtacca atcactgctt tccggaacgt ccgtctggtc accccaaatt tgcggggatg 3206881 ctggaggaag atccgcatac cagtcataaa aactgagcat agggcctccg attaacgaca 3206941 taaaccggga gcctgatgcg tggctgatca tggacatggc cggaatcgga gaaaaaccga 3207001 cgtttcggtc aggcccgtat ttcatcactg tatacagcag agaggctgaa atcagcttca 3207061 gcacctccgg ccattcagcg cgcacaaaac cgcctttccc tctcgcctgt ttataggact 3207121 tcgctttttc agggttttcg acgatcgatt tccaggcttc caatggattt tgatgcgtct 3207181 gcaatgcctc ccgccacaaa ttgatcagca caccgcgcac gtatggatat ttcacacgga 3207241 gcgggctgta gatataccat gaaaaactgg ccccccgcgg gcagcctctc ggttcaaaat 3207301 caggcatatc cgggcctgtt gatggataat tcaaattttg cccttcccac gtgactattc 3207361 cgtttttcac ataaatattc cagctgcaag accctgtaca gttgacgccg tgggtggagc 3207421 gaacgacttt gtcgtactgc catctgtttc tgtatacatt ctcccaatcg cgatcctcgc 3207481 gggtagtttg gctatgttta tttgaatggt gttcgatagg agagaaataa ttcaatctcc 3207541 taaacaacgg actccttttc tttttcttca tgagagttca ctccttccga gtcaggtgat 3207601 gctaagttca ctataaacag agacagcgtg tttccttgtg aactatgtca cacactctgc 3207661 ttttttcaca aaatgttcac acaaaggaga aggaaggctg cgttcaggca ggacgcttgg 3207721 gtcattagct gcctttcatt caaagatcaa aaaaaaccgg ctctatttaa gaaccgggct 3207781 cagcgttttc atcctgtgat gtatgcagat accgcaaaaa taattgatag gaacaaaaaa 3207841 cattttgctg aagcatagcc aaaaagttca tttgcagctg cggatgataa gacatcattt 3207901 tcttaaatat gtaatatggg atgttgagaa tcagaatgtc tgaagtggca ttgactgaga 3207961 taaagggcga taaataaagc ccgccttttt catcaatcgg aaacacatcg cctttttccc 3208021 acagcgcaac ggttttcgac ccttcaggga gccttgtgtc cataaaacgg acactgcctt 3208081 ttaatacaat ataaacagat tgagaatgaa gaaaagatgg agactgatca catgaaccgc 3208141 ggataaacgt gccgtttttc agcaaggttt cgacaatgga tagaggcact tcattaaaca 3208201 taggaagttg tttcagaaat aataaatagt cacactgatt cataggaaaa cctcctgtgc 3208261 taaggatagc tttagtgtag ctcgactgag cctgtacagc agtgatgtat ttcacagcct 3208321 gtatgatgaa tgtcacttat caggagggtg aatgcattta taatgaaaga aaaaaggagg 3208381 atttcgatga aggcgctgat tccgaagcag cacggggcgt gggcgatgct gctgatccca 3208441 tttttactcg gcatggtcaa gggaggcccc gttatttggc atattccgct cttccttggt 3208501 tggcttttcc tatacttagc ggtttatccc gttacgcttg ccttaaaaaa gaaacaaagc 3208561 aaaccatatc aaaagtggat gtgttattac ggttttccca cctgctgctt tttgatgatc 3208621 tcggtctttc ataagccgcc tctcatctgg gtgggcgttt ctttactgcc gctgtttctc 3208681 atacatatgt attttgcccg cagaaaaaac gaacgagcct tattgaatga tgttgcaggt 3208741 gtcttgttct tttgttcggg cgggtttgcg agctgctggc tggggatggg aacccttgac 3208801 ggctgggctt ggtttatttt cttgcagtct gctttatttt ttatcgggag ttccttttat 3208861 gtgaaatcgg tgatccgcga gagaaaaaac agggcatttg catactggtc atggggatat 3208921 cacctgctgc tccccttttt atccgctctt ttcggagcag gatgggcgtt tctcgctttt 3208981 atcccgagca gcttgcgggc atggtttttt catggaaggg attggcccgt aaaaacgatt 3209041 ggcattctgg aaatcgtgaa tgcctgcttc tttcttgccg tcatgtgcct gtttatcaca 3209101 aggtaaaaaa acaaggacac cgctgtcctt gtttttttca gtcaatattg caaatctcca 3209161 gcgggcaatt ttcacactca atctcacatc gtaaatagtc ccgcttgtgc aaaataattt 3209221 ttccggattc gtctatcgaa ataacccctt ttttgcggag atctccgagc atacgattga 3209281 cgctttcccg tgcagccgcg caaaactttg ccaaatcctg atttgtcagg acaatgttaa 3209341 tcagaatgcc gtcgcttcgc tccactccgt agctgtttga taagcggata agggtagaat 3209401 agagcgcccc ctttttgcca tgaagaagca gatccctgat tttggactga atcttccgga 3209461 ggtgcgtgct catccatttc atgaactcaa atgtcaaagc gccgttttgg attaattctt 3209521 tttccagctt atttttatta atgacgagca cctcgccatc ctctagtact tttgcactga 3209581 gcatatacct tggttcttca gtgaaaagtg ttaattctcc gacgatatca tgcttttggc 3209641 agattctaag cgtcaggtct tttccgtcag atgtcagctt gccgatttca atgagtcctg 3209701 attgaatcag ataaagctct tctgcatcca ttccttcccg aaacaaatac gtgtgttttt 3209761 ccatttttct tttcgtgctg atcgattcca gcaattcata cagatcgctg gatataagat 3209821 cactatcaga tggtcgaaca gagagaaaat tcatgagctc acctcgaaga aagtcacgtt 3209881 gtgtgtttat tgtaacgtga attgatttgt acccatcgag aaaaaactaa caatcttgtg 3209941 aatgccccag tgttagttga tgctctggct gtttctctcc gtgtgtgttt tcattctttc 3210001 ctgccaatac atccatatga caaggacaaa actggctaac gccacctctg aaagcgccat 3210061 aaacccgatc gcgtactggc ctgttgcctg aaatacactc gccaatatga gcggaggaaa 3210121 aaagccgcct aaaccgccca tggcagacac aatcccattg gcaatccccg cttgcttcga 3210181 aaaatagaaa ggcaccagtt taaaaacagt tccgtttcct atgcctgagc agacggccac 3210241 ggttaatgat ccaaacgtat aaaggccgat tgtcggcgag aacgatagga taatgcctga 3210301 taatgtaagc ccggcaaaaa caaacatcaa gatgcggagc gggctcattt tatcagccag 3210361 gaatccgccc gcaggcctga gcagcgtaga aaccgcaata aagccagccg tccgcaagcc 3210421 ggcatctgca ggattcagcc caaaatgctc caccagaaag ttcggcagat agatagtgaa 3210481 ggcgacaaag gcaccgaacg taataaaata aaacaggctc agaaaccata gcacatgatt 3210541 tcggtaaaca gctttgattt gagtcttaac agaaactttg accttcttct catgcctgtc 3210601 gccaaacaat acgtgcagta aggcaaagac agccagcaaa atcagataca tttgcacggt 3210661 tgatttccac ccgacggctt gagcgataac cggcgctgca aatgtcgtaa cggctgtccc 3210721 gatatttcct gcaccgtaaa tcccattgac gacaccgtgc ttttctttcg gataatattt 3210781 cgggagggag gtcaccccaa tggaaaacac cgctcccccg atccctaaga aaaagccgcc 3210841 tgcgattaaa tcaaacagag aatccgcgat actgatccaa aatacaggaa ataaaagcag 3210901 gatgaagctg accataaaca tgagccgcgc gccaaacctg ttcgttaaat accctaaagg 3210961 aatgcggaga agcgacccga ggatcacagg aatcgcggtc actaaagaaa tctcaccctt 3211021 gcttaaatga atatctaatg tgatttggga aatgagtgat gaaatcagca cccaaaccat 3211081 aaaccctgcc accaagctta atgactgtaa cgataattga atgtgttgac ggttgatcat 3211141 ttggcttgcc cctttcaatg attcaataat cagtcttatc atacaaaaac tagccaaaca 3211201 ggattgtgaa ttacatcaca cgtttttctc ataaaaaaag gacaaagccc gaagactttg 3211261 tccttttgat cgtgattaca ttttttccgg agccgatacg ccgatcagct gaagcgcatt 3211321 gttcagcgta atttgcgttg ccttcattaa agccaggcgc gcgcggcttt tctcttcatt 3211381 ttcagggtcg atgactttct ctgcgttgta gaagctgtgc agagcagaag ccagatcata 3211441 aatatagtta gtgacacggt gcggaattcg tttttccgct gcttccgcca ctgcctctgg 3211501 gaagccgccg atcgttttca gcagatcgta ttctttttct gattgaatat ggctgaaatc 3211561 aagatctgcc gccggtttaa gcccctgctc ttccccttgg cgaagcatgc tgcaaatacg 3211621 ggcatgcgcg tattgtgcat aatacacagg gttttcgtta gatgttgata cagcaagatc 3211681 taagtcaaaa tccatatggg tgtctgcact tcgcattgca aagaagtaac gcacggcatc 3211741 caagccgact tcttcaatca ggtcacgcat cgttacggct ttaccggtcc gtttgctcat 3211801 tttcattttc tcgccgtttt tgtaaaggtg aacgagctga atgatttcta cttcaagcgt 3211861 tcctttttca tagcccagcg cttcgattgc cgctttcata cgcgggatgt agccgtggtg 3211921 atcggcgccc caaacgttga tcagcttatc aaagccgcgg tcaagcttgt ccttatgata 3211981 cgcgatatca ggaagaaggt acgtgtacgt gccgtccttc ttgatcaata cgcggtcttt 3212041 atcatcgccg aaagtcgtgg aacggaacca agtcgcgccg tcttcttcat agacgtggcc 3212101 tttttcgcgg agcgcttcaa gcgccttgtc gatttttcca ttttggtaca gtgaagtttc 3212161 tgaataccac acatcaaacg gcacacggaa gttttccaag tccttgcgaa gcttttccag 3212221 ctcgtatttc aggccgtatt cacggaaaaa cgcgaggcgt tcactttcct cttcgttaac 3212281 gaaacgatca ccgtattcct cagcgagacg ctttccgatc gcaatgatat cctcaccgcg 3212341 gtagccatcc tccggcatcg gtttttccaa tccgagtgct tcaaagtaac ggacttcaac 3212401 agaaagcgcc agattgttga tttggtttcc cgcatcgtta atgtagtatt cgcggcttac 3212461 atcgtaaccc gcttttgaaa gcacgttgca caaggaatcg ccgacagccg ccccgcgcgc 3212521 atgcccgagg tgaaggtctc ccgtcggatt cgctgatacg aattctacct gaactcgttc 3212581 accgtttccg atgttcgttt ccccgtatgc ttcccctgct tccagtacag acggaatcag 3212641 ctttgttaaa tattgattgt tcatatagaa attgataaaa cccgggccgg cgatatccag 3212701 tttttcaatc gaagccttcc ctttatcaaa atgggcgaca atctcttcag cgatttgacg 3212761 cggcgctttt tttgccactc ttgccaactg catcgccata ttcgttgagt agtcgccgtg 3212821 tgttttatct ttcggtgttt ctaaaacaac attgggaatc tggctttctt cagccagtcc 3212881 cgctttcaga acggccgctt tgatttcttc tttcagcacg tccttcattt gttccgcaat 3212941 gttcatgcgt gagttcctcc ctcatacgtg atcgtcatat tatgtaaatg ctcctgctcg 3213001 tctccgacat gcatgtcata tgcgatgctg atacggcctt tttcttcatc gagatcagat 3213061 tgaatcgatt ttgtgcttgt tttcagctca agctcaccaa atgacatttt atatttagca 3213121 attgtggaag ctcccgttac gaaacgctga ttcattttga cagcgcctga cctcatgacc 3213181 aggacttcgc cttcgcttac tttcacaatc gttttgactt tgcctaagtc gtgttcttca 3213241 taataagata gatacacttt attttgtttt acatagtaaa atccggtggt gcggaattcg 3213301 atgacttctt ggtttccgtc atcctcgatc acagacttca catggagtgt tatcggtgtc 3213361 tcttgcttca ttctgacacg tccttttcat cattccactt tgacttgaat agtataatca 3213421 ttcggtttgt aaacttcaac tgcttctatc ttaccatcat tgctcatcag atttgaagat 3213481 aaacctcata aaaagcattt ccttatatag aagagaaaat catatcacta attaccttta 3213541 ggaaatgtta cgagctcgct acatcgcaat cgcagacgga cccgcgccaa ccggaatcac 3213601 cgtcacggct gtataatcac ttgtgcggta cacggtcaca gcattgtcgt tgggctgtgc 3213661 cgcataaata tactgtttgt ccggcgttac ggcgaggtca aaggcgccgg ggagagacac 3213721 gtttgcaatg atcctctgtc tggccgtatt aactacgtat aagttattaa tgagaaacgg 3213781 ttcactatat ggctctagaa aataagctct agtactatcg agagaaaata caatcgtcct 3213841 cagcgtttca aataaacggc tgaagtcccc tcccctgctt aatggtgaca aactaatctc 3213901 cgttacacct ttcggccaca gctcaccatt caatacgtac gcaaaatttc cagcgtaagg 3213961 agttgtaatt aaactgggaa attcaaatgt atctatgata ctttctacca actgcccagt 3214021 atttacatca tatttatcaa ccgaccaact gcttccatta gcggtataga catactgtcc 3214081 attcggatca agagcaaagt ctaaagcgcc gggtatcgga atgacatcaa tgaccgattg 3214141 agaggccgtg ttaatcacat atatagatcc ggcggccatc acgtatgcga actcatctgt 3214201 tggatcaaat tcgatttttc tcggccctcc tccaacagta atggtattta tgatggttaa 3214261 tgttttatta tcaatcactg agacaaggtt ggtatttcca tggaggacat acgtgaatgc 3214321 tttatcgaaa gtaacgccta gattagttgg cacgtcagaa aaagggattg tttttacaac 3214381 agtgtttaaa tctgcatcaa taaccgaaac cgtgctgtct ccagtattgg cagtaaacac 3214441 atacgattga gggtctggtg atggcggtaa aacaagtgtc ccggccaccg taagcggact 3214501 gccgtagaaa ggcggtacaa tgagcagatc ttccactgtt atttgactga aatcaggaca 3214561 gcggccagac tgtgctgcat aataaacaac ttgatcaatc tcttcagtat gaatcacaga 3214621 aacagccccg tctccttgtc catattgatt tcgtacaggc gacacactga caagaagcgt 3214681 aatggtccct tgtactctca cagcatatcg aacaccgata tcttctggtt ccggcccagt 3214741 ctggattaag caaggctcac tgatacagga caaattgtct gtactccatg taacagccgc 3214801 tgacgcttcg gccgtatcaa ccttgaagcc ctcagggaaa tctatcggca cttgaaacgg 3214861 cgcttcccgg ctaatttcct catcacaaaa acagaaacaa ttttcctgta aagcagaaag 3214921 atcattcttt ttcatgattt cacgtccttt tagaaatgca caacatgcag cggttaaatc 3214981 gtaatggcac ccggtgaaac cccaagagat atcacagttt cctcagaata atcatctgtg 3215041 ttgtaaacaa tgatgctctg ctctataaaa cgagttgcat acagaaaatc gccattcggg 3215101 gtaaacgcat agtctgttgc tgattgcgga acatttccta taacgcctgc tccatttgga 3215161 ctgacagaat ataaattgcc agtgaagccg tcatataaat acacctctgc tccactcgta 3215221 aacattcgat attccccttc atactccagc tcttgggtgc tgctgatggt aaacgtattt 3215281 aaatcaataa ccgtcaaata attaaaaaag aattcttgtt ctaatacata ggcataccgc 3215341 tccggccaat ttgtttctat ggttgatacg ataagctctc gttcaattgt tcctgtgact 3215401 tcaccggtag ttaggtccac tttttgcact attccaaaat tcagaacata ggcgaataac 3215461 ccattgggat cgattgcaac atcatatcct tccacaggaa tcgacctatc cacagttaac 3215521 gtatcaattc caatcacata aaccgcagta ccggtgaaaa cataagcaaa ctcatgatta 3215581 gggataaatc taatcaatcg aggcggctga tccagcaata tagttgctgt cactgttaat 3215641 gtgtcataat cgatgacaga aatcacatta ttgttgggat gtaagacaaa cacagcgctt 3215701 ttatctggcg taatttcaat acctgccgga ttgtacggaa gagcaatcgt tgtcacaaca 3215761 gtatcggtgt ttgtatcaat cacagaaact gattgatcat ttggattcgc tgtaaacgcg 3215821 tagacgggtt ccggctccgg tacaagcaca attgtccccg tcaccgataa aggactgccg 3215881 taaaacggcg gaacaacaac aaggttctca atcgtgatgt cactgatatc cgggcaatca 3215941 tccgattcat cggaataata gacgacttga tcgatttctg cattgtgaat gacggaaaca 3216001 gccccgtccc cttgtccata ttgatttcgg acaggtgaga cactgacgag tagcgtaacg 3216061 gttccctgca ggcgcactgc aaattgaaca ccgacctcat caggctcagg ccccgtttga 3216121 attaagcaac ggtcactgac acaagaaagg ctgtctgcat tccacgtcac gtttgcaaca 3216181 gcttcagccg gatcaacgac aaacccttca ggtaattcaa tcggtgcttg aaacatggct 3216241 tctcggcttg cttctccctc acaaaaacat aagcactctt cttgttctgc tcctgctttt 3216301 tctttaaagg aaagcttgtt ttttctcatt ccttcacttc cttttcagac atacactgct 3216361 cacgcagata taacagaata tggaagggta acgtgtttgc ttgtacaaat tgctgagggt 3216421 aaacgcttct ttttgaaaat atatctccaa acatgcggtg taacgaaaga aaaaattgcg 3216481 gtttttttgc gcttctcaca agaatgttga tgataaaata tgacatatat agaattatga 3216541 agggagggat ttgcaaacgt gacaggtgtc atatcttctt cttccatcgg agaaaagatt 3216601 aacgaatggt atatgtacat acgccgattc agcatacccg atgcagaata tttgcgacga 3216661 gaaatcaagc aagagctgga tcaaatggaa gaagatcaag accttcattt gtactattca 3216721 ctgatggagt ttcggcacaa cctaatgctt gagtaccttg aaccgttaga aaaaatgagg 3216781 attgaggaac agccgagact gtctgatctg ctgcttgaga ttgataaaaa acaggctcgt 3216841 ttaactggtc tgcttgagta ctattttaac ttcttcagag gcatgtacga gctggaccag 3216901 cgggaatatc tgtcggctat taaatttttc aaaaaggccg aaagcaagct gatattcgtt 3216961 aaggatcgga tagagaaagc tgagtttttc tttaagatgt ctgaatctta ttactatatg 3217021 aaacaaacgt atttttcaat ggactatgca cggcaagcat atgaaatata caaagaacat 3217081 gaagcttata atataagatt gctgcagtgt cattctttat ttgccaccaa ttttttagat 3217141 ttaaaacagt atgaggatgc catctcacat tttcaaaaag cttattctat ggcagaagct 3217201 gaaaagcagc cccaattaat ggggagaact ttgtacaata tcgggctttg taaaaacagc 3217261 caaagccaat atgaggatgc cataccttat ttcaaaagag caatagctgt ttttgaagaa 3217321 tcaaatattc ttccttcctt acctcaagcg tattttttaa ttacacagat ccattataaa 3217381 ttaggaaaaa tagataaagc tcatgaatat catagtaagg gaatggctta ttcacaaaag 3217441 gccggagatg taatatattt atcagagttt gaatttttga aatctttata cttatcaggc 3217501 ccggatgaag aagcaattca aggatttttt gattttctcg aaagtaaaat gttgtatgct 3217561 gatcttgaag atttcgctat tgatgtggca aaatattatc atgaacgtaa aaattttcaa 3217621 aaagcttctg cttatttttt gaaggtggaa caagtaaggc aacttattca aggaggagtg 3217681 agtttgtatg aaattgaagt ctaaactatt actctcttgt ctggctctaa gcactgtgtt 3217741 cgtggcaaca actattgcaa atgcacctac acaccaaatt gaagttgcac aacgaggaat 3217801 gatttaaccg ccgtccatcg gcggtttttt cgtcccctct ttaccaaagt ctcccaatcc 3217861 atgctatgat cttttcaata atcttgaaga gagtggaaat gcagcatgtc tctaaaaagt 3217921 gtgagaaccc actttactca atggaatcga gaaaatgatg tgacggagtt cgaaacgtcg 3217981 agtgcgacag ttgaacaggc agctgagaca atcggcgtaa gcctgtctag aatcgccaag 3218041 tccctgtcct tcagagggga aggagatcag gtgattctga ttgtggcagc cggcgatgcc 3218101 aagatcgaca acaaaaagtc caggcaaaca tttggcttta aagcaagaat gctctctcct 3218161 aatgaggtgc tggagcagac aggccatgaa attggaggag tttgcccatt tggattggct 3218221 catgatcctg aggtttatct tgatgtatcg ctgaaacggt ttcagactgt tttccccgca 3218281 tgcggcagca gaaactccgc tattgaatta acaccgaaag aattatccga attttctttc 3218341 tcaaaagtgt ggattgatgt ttgtaaagac tgggaataaa aaaacatcca gacatcgtct 3218401 ggatgtttac ttatttcaca aacccaagca gcatttcacg gatgattttg ctggctgtgt 3218461 ttgccgtttg ctctgagtgg tcgtataccg gcgcgacttc cactaaatca gcgcccttta 3218521 cgtttacctc tgaacgcgca atttcatgga ccgatgcaag cagttcttta gacgtgatgc 3218581 cgccggcgtc aaccgttcct gtacccggtg cgtgtgcagg gtctaatacg tcaatgtcaa 3218641 ttgtgacata aaccggacgg cccgccagct tcggaagcac ctctttcagc ggttcaagca 3218701 cttcaaattt tgagatgtgc atgccgtttt ccttcgccca ttcaaactct tctttcatgc 3218761 cggaacggat tccgaatgaa tacacattgt gcggtccgat caattctgcc gccttacgga 3218821 tcggcgtgga gtgagaaagc ggttctccct cataatcaac acgaagatct gtatgtgcgt 3218881 caaaatggat aatcgcaagg tctgggtatt tcttgtacat cgctttaatg acaggccatg 3218941 acacgaggtg ctccccgccc atacccattg ggaacttccc tttttctaaa atgctgtcca 3219001 cgtactcttc aatcatatcc aggcttcgct gcggatttcc gaacggcagc ggaatgtcgc 3219061 cagcgtcaaa gaagttcaag tcagccagat cgcggtctaa atatgggctg tattcctcaa 3219121 ggccgattga cacctcacgg attctgcttg gaccaaagcg tgagcccggg cgatagctga 3219181 ctgtccagtc catcggcatg ccgtaaagaa tggcgtccgc ctcttcccac tcgggacggc 3219241 tcgcgataaa tacttttcct gaataagctt catcaaatct catctataat accctcgctt 3219301 tcctgtaaaa aagcgcaaga ttcgctcctg cgccatacct tcattattta atcaggtcac 3219361 tcacaaattt cggcagaaca aacgccgctt tatgaatatc ttttgtgtaa tatttcgtct 3219421 caatatcgaa gaaacggctg tcttccactg caagcggatc atattttttc gagccaattg 3219481 taaatgtcca caaaccgctt ggatatgtcg gaatgttcgc cgtatacagc ttcgtaatcg 3219541 ggaagatttc cttcacgtcg cgctgtacat ttgtgattaa ttccggtgta aaccatgggt 3219601 tgtccgtctg cgcaacgaaa ataccgtctt ctttcagcgc ttttgcgatt cctgcgtaga 3219661 atccttttgt aaacaggttt acagccggtc cgactggttc agtcgaatct accatgatga 3219721 cgtcatattg attttcagat tttgcaatgt gcataaatcc gtcatctacc tgcacgtcaa 3219781 cgcgcggatc atccagtttg cctgcgatag aaggaaggaa ctttttagag tattcgataa 3219841 ccttgccgtc aatatctaca agtgtcgctt ttttcacgct tgggtgcttc aggatttctc 3219901 tgataacgcc gccgtcaccg ccgccgacta cgagaacgtg ctccggattt gggtgcgtga 3219961 ataatgggac atgcgccacc atttcgtgat aaacgaattc gtctttttca gatgtcatca 3220021 ccatgccgtc caaaaaaagc atgttgccga actcttctgt ttccaccatt tctaaatgct 3220081 gaaactccgt ttgttctgta tgtaacgtct tgttaacctt catcgtaatg ccaaagtttt 3220141 tcgtctgctt ctctgtgtac caaagttcgc tcaattgtca tctccctttc gaggctgtat 3220201 tcatttattg taagcgtctt atcagctttt attctcggtt gaaatctcat tttcacctaa 3220261 ggaaaaagta tagaggatgg cggggaaaaa gtaaagatgc gtcctgttct gcgatgttta 3220321 aaaacgatct ttttttctca taatagtaga aacataaaaa aagggggaac ccgttgtgga 3220381 tgcaatgaca aataaacggc tgagactgac gctgaaaacc gttcgcgcct ttatcttttt 3220441 aggggctttt gcggccttgg cggcagctgc tgtgtttatg actgtcattt tgatagccaa 3220501 ataccagggc gctccctcgg tgcaagtgcc gcaatccacg attttgtacg cgagtgacgg 3220561 ctcaaagctc ggggaaacga actacggcga aaagcgctat tgggtcccct taaaggacat 3220621 gaatccgacg atcgtaaaag cgacagtggc gattgaagac cagaatttct acgatcatca 3220681 cggctttgat tataaacgca tggccggcgc ggcgcttgct gacctgaaag catttgccaa 3220741 ggttcagggt gcaagcacca tcacccagca atatgcgaga aacttatacc ttgaacacga 3220801 caaaacgtgg aaacggaaat ggaatgaggc gttctacacg atccgtctgg aacaaaacta 3220861 ttctaaggac gagatattag aaggctattt aaatacgatt tactacggcc acggcgccta 3220921 cggcattgaa gcagcttccc gcctgtattt cggcaagcat gccaaaaacc tgacggatgc 3220981 ggaggcggcg cttttggcag gaatcccgaa aggcccttcc ggctattcac cgtatgtcaa 3221041 tgagacgaag gccaaggaac gccagaaaac gattgtgcgg atgatggaaa agcagcagat 3221101 gatcagccaa aagaaagcgg atgaattgat caaggaacct ctttcctatc agcctttgaa 3221161 taaacaagtt tccaagagaa aggctcctta tttctacgac aatgcgatga gagagctgga 3221221 aaaaaagctc ggcatgacac gggagcaaat tgaaacgagc gggttaaacg tctatacaac 3221281 ggtagataaa cggatgcagc gcatcgccga ggagaccatt accgaaacgg ttaacgcggg 3221341 ctctgacatt caagtcgggt tttcagccat tgatccccgc accggaaacg ttctcgccct 3221401 tgtcggcggc agggattatc aaaaaagccc gtttgaccgg acgacacagg cgaagcgcca 3221461 gcctgcttcg acgatcaagc cgttgctgta ctataaagcg attcagagcg gatttacgcc 3221521 agtcactttg atgaaaagcg aagaaaccga gtttcaaatt gatgcaaagg gagaaaccta 3221581 ttctccaagc aactataacg gatactatgc caacaagccg attacgcttc tgcaggcgct 3221641 ggcgctttcc gacaatattt acgctgtgaa aacgcatctt tttctcggca cgaacaaact 3221701 tgtaaagacg gcaaaggaat tcggcattac cgcccatctt caagcactgc cgtccctggc 3221761 actcggcacc gaacccgtac gtccgattga gatggtcaac gcctatgcca tgctcgcaaa 3221821 tggcggaaag aaaatcgaac cgacttttat ttcaagagta acggacgcag ccggccacgt 3221881 gctgtacgaa aacccgaatc agcataaaca ggtgcttgat gaaaaagccg cttttgtcac 3221941 agcgagtatg atgacaggca tgtttgatat cgatttaaat ggatatacgt cggttacggg 3222001 gcgaacgata gccaaccgcc tgacaagaac gtatgccgga aaatcaggaa ccaccagcgc 3222061 agacagctgg atgatcggct tcaatccgaa gctggccgcc ggtgtttgga ccggctatga 3222121 caaaaacagc accatcgact cggtcgaaga aaaaagctat gctaaaacca tttgggcgga 3222181 cttcatggag gacgcgctca aaggcgaacc ggaaaccgcg ttcaagccgc caaaaggcgt 3222241 aaccggtgtg tacattgatc cggaaacagg ctactcatca ggtcccggct gcgccgctaa 3222301 gcattacaca tattttgtga aagggacaga acccgcaaac gtgtgctacg gggcagaacc 3222361 cgcaaaacaa acaaaagacc ggcttccatc caaagaaaag cccgcttccg agaaaaagtg 3222421 gtgggacaaa tggctggggc gacatcattg aaaataaccc ggctcctcgg aggccgggtt 3222481 attcgtatgg ttccttcata atcgatggaa gaatgttaga caatcgagct gaacaatcag 3222541 ttttgggata aagtggtgaa tttctcattt cttcggcgct ggctttcatc tcccagtcgc 3222601 cgactcatat ccccctaaaa atgaaaaacc ccgagtcttg tttcggctcg ggattttcca 3222661 tgtcctattt ctgtatcacc agtttactca atgtttacga aaaatatctc aaatacttta 3222721 aaagttcaca aaaaattcat aaattaattg ttttctggaa gcaggctcgt ttttaactca 3222781 tctgaggaac ggtcccatag gccctgatca tgctttttca gaaattcgcc tagtacacgc 3222841 ttcgagctgt cgtccatttt atcaacgatg attttccgtt tcatggattt atccatcaga 3222901 ttcacatgct caggcagtga cttgtagcct cttctgatgc ttctgtcgac cgtcatttca 3222961 caggctgtca caccagcgta ataaggcccc tcttcttttc tgtcaatcgt tacccacaca 3223021 agccagtatg gttttccgtt cggcacttct tctttattcg ggagaaattt aattcctttt 3223081 tcaacggtgc tgcgggcatg catagcgccg atgtctacga acgcttcttt ttcctctaca 3223141 tcaacgaata cgggagaaat gttatcaagg ctgagtgccc ctacgccaaa accgccgtgt 3223201 ccgtctgtcg gatcactttt gataatatta aacccgattg attttttctt tttttcttcc 3223261 atgaagttct acctcctaca aaagcggttg aaatatcgct gaaaacagct ttaaaatcga 3223321 atctcttcct gcattgagca tcggccacag cacgtaagat cctagcggtg tcacaaacag 3223381 caccaaaaat acgataaagc cgtagctctc cgcctgcgtc attttggcac gcacgcccgg 3223441 cggaacgaga tcttctataa ttcgatagcc atcgagcgga ggaagcggca gcagattaaa 3223501 taaaaacaag acaagattca gctgtatcca aatagaaaaa aactgatcca gccccgtgct 3223561 gaacgccgca agcatttcca ttccgtacgc atgcatcaac actaacaaaa agaaaccaat 3223621 aaacgcaaga atcaggttac tgacgggccc ggctatagat acgagcacac cagcaagccg 3223681 gggtttctta aagaaacggc gattcacggg aatggggcgc gcccacccga atccggccac 3223741 cagaatcaaa atggttccga acggatcaag gtgtttaatg ggattcagcg tcagtcttcc 3223801 ttgttttttc gccgtatcgt caccgaattt gtatgcgaca taagcgtggg caagctcgtg 3223861 catcgtaaac gacacaatta gcgtgatgac gaggtatggc attaaagata acggataata 3223921 taaaaaacgg tccaagtgag atatccctct ttctcaaaat gcaagaattt actttattca 3223981 gtatactata agaagcctct ttttctaaag agaggaaacg agataaagga ggattcagca 3224041 cccatgccat acgtaactgt caaaatgctc gaaggccgta cagacgagca aaaacgcaat 3224101 cttgtcgaga aagtaacaga agccgtaaag gaaacaaccg gtgcttctga agaaaaaatt 3224161 gttgtcttta tagaagaaat gagaaaagac cattatgccg tcgcaggcaa acgcctgagc 3224221 gatatggaat aatctctata aagccggcgc ttcgcgcacc ggcttttatt atccctattg 3224281 agccagcttc gcaataatcg ccaagaacgt ctttttctct tcggctgtta aacgttcaaa 3224341 catgccatca atcagctgct ggcggttttc gatcatttgt tcagccgctc cccggcccga 3224401 ttcagaaaga gtaatccata cagtgcggcg gtcattgtta tttctggatc tctcaataaa 3224461 cccttcctgc tctaaatgat tcagagctgt ggtcgtggca gagggagaca gtgtgacctc 3224521 cttcaaaata tcctttatgg tgcagctccc atgtctgtat atgatccgca gaataaaccc 3224581 tcttacatta ttcacgtgtt tcggaacggt ggcttcatct aattgcttcg tgcttttcaa 3224641 atactttgta agtgcgtgat ccagcaaatt tgcttccagt ttgtcatggt ccatgtcaat 3224701 ttccccattt cgagatgcat tcataacata cgaacgatat gatttactta ttattttact 3224761 gattccgaat agggaaagtc aaaaaagcaa aatgtgaatt cacagctttt atcctacatg 3224821 cctcgatttt ccacctgttt cacaagttta tctttaaaag tttggaaagg aacgtgttca 3224881 ttctgctgat gtccgaatcg gcggacgttt accgcattct cctgctcctc atgatctcca 3224941 agcaccagca cgtacggaat tttttgcacc tgcgattctc tgattttata gccgagcttc 3225001 tcattgcgct catcaatgcc ggctcttatc cccgcctgct tcagctccgc ctgcactttt 3225061 ctgcaatagt ctaagtgaac gtgcgaaacc ggtatgattt gaacctggat cggtgcgagc 3225121 cagactggaa aagccccacc gtaatgctcg atcaaaatgc cgaagaaacg gtcgattgag 3225181 ccgaaaaccg ctctgtggat gacaacggga cgaaccttct cattgagttc gttgatatat 3225241 gttaaatcaa atttttccgg catttgaaaa tcaagctgaa ttgtcgcgca ttggtggctc 3225301 cgtttcaggg catcttttat atggaaatca attttcggcc cgtaaaacgc cccatcgcct 3225361 tcattgatct cataagagag gccaagctcc tcaaggacgc gtgctaaggc acgttccgac 3225421 gcttcccaaa ggctgtcatc gcctaatgaa tcctccgggc gagtcgaaag ctcaacagaa 3225481 tactcgaaac caaatgtccg atatacctca tcaatcagcc gaatcgcttc tttgatctca 3225541 ctctcaatct gatcctcccg aacgaaaata tgggcgtcat cctgacagaa cgtccgaacg 3225601 cgaagcattc cgtttaaagc gccgctgtat tcatggcggt gcacctgtcc gaattccgcc 3225661 atgcgaatcg gcagatcccg ataagaatac aggctgtttt taaagatgag catgtggccg 3225721 gggcaattca tcggcttcat tgcgaatctt gtatcatcca cttctgaaaa gtacatattg 3225781 tcgcgataat ggtcccaatg gcctgactgc tcccataacc gctgattcat cataaacggc 3225841 gtacgcacct catcgtagcc ggcatttgtt tgcagctcac gcgagaagcg ctccagctca 3225901 ttgcggacaa tctgcccttt cggcaaataa aacggcatcc ccggcgcttc ttcagaaaac 3225961 ataaacagcc ctaactgttt gccgagcttg cgatggtctc gttttgccgc ttcttctagc 3226021 atatgcaggt gcgcatccaa atcttttttc ttttgaaacg caaccccgta cacccgctgc 3226081 aggacttcat ttttgctgtc tccgcgccaa taagcgcctg atactcttgt cagtttgaac 3226141 gccttgatca tccctgtaga aggaagatgc ggccctcggc acaggtcaac gaattcccct 3226201 tgctggtaca gtgtgatatc ctccccgcgc ggaatatcct ttaaaatctc aagcttgagc 3226261 cgctcgtctt tttgtgcaaa cagctcttca gcttcttcgt aagaaacctc tatacgtttg 3226321 atttcaaggt tctcatttat tatgtttttc atttcttttt cgatggcctc taagtctcct 3226381 gatgccaagc ttttccccag cttcatgtca tagtagaagc cgtctaaaat cacaggccct 3226441 acccccaatg acacttcgcc gtacagccgt tttactgctt gggccagcac gtgcgctgtt 3226501 gtgtggcgaa gcacctgcaa gccttcttgt gaatcgagtg tgacaatcga aagctcagca 3226561 tcctcctcca gcttgaaact gagatcaaca agcttgccgt tgacctgacc tgcggccgcc 3226621 ttcttttgca gactggaact gatcgaacca gccgcttctt tgattgtgat gcctttcgga 3226681 tattcctgga tctgtccgtc cggaagctga atgtgtacat gtttgctcat tttagaacac 3226741 tccttattca ttgttgtata taaaaaaaca cacccgtccc gcagataggg acgagtgtgt 3226801 gattaacccg tggttccacc caagttcccg acaaatacta tgttgtcggc tcggtgctgt 3226861 aacgcagcat agacggcatt ggttacttca gttccccaat gctgctccaa ggcggtaaat 3226921 gatattccta agctgggaag ctctcacctt tccttccctc tctgaaaacc gtaactatca 3226981 ttcatgtcct tttcatcgca tgtattcaat tcataaaaaa acacacccgt cccacagata 3227041 gggacgagtg tgtgattaac ccgtggttcc acccaagttc ccgacaaata ctatgttgtc 3227101 ggctcggtgc tgtaacgcag catagacggc attggttact tcagttcccc aatgctgctc 3227161 caaggcggta aatgatattc ctaagctggg aagctctcac ctttccttcc ctctctgaaa 3227221 accgtaacta tcattcatgt ccttttcttc gcatgtattc aattcaaata aaaaaacaca 3227281 cccatccctc taaaagggac gaatgtgttg atcatccgtg gttccaccca aattcccgat 3227341 caattacaca tgatgatcgg cttaaagatg ctgtaacgca gcatgacggt atcagatact 3227401 tgttttccct gatacggctc aaaggcggta agctgctttc cctgcgttag gaagatctca 3227461 gctgtccttc cctctctgga aaccgtaaaa agcatctcgt gtccttatca gtgcctgttg 3227521 tttcaataat tttttatatc ttactatata ttcccacaaa gcgcaatcag tgatttacat 3227581 tttttctgac gcggcagtcc cgttatgggc agccagaaac agccatacaa gcaatgcagc 3227641 gaggctgtat gccgctccca tcatcaaaaa cgcaaacccg gcaccagcat accaagtggc 3227701 ggacagatga atgatcaccc cggttatcgc tacgccgacc aaggctccga tttgccggtt 3227761 tgcatttaac gccgcaccgg cgatattcgt atgtctttgc ccggcagcct gcatgatcac 3227821 agttgtcatg gcaggaactg taataccggt acagaggttc ataacagaca tcaacaccgc 3227881 cagctgccaa taaggaaaat ccggagaaat cagcacaaac aacagcaatg caatgataca 3227941 gctgaccgcc attgatacaa acataagctg accggcttca aaccgattcg ccagacgggc 3228001 aaacagcaga ttgccgatca cgaagaccgc catcatcggc agcagctcca ctccagccat 3228061 aaaggaactt gcccctcctg cttcctgcaa aaaaaggctg agcataaaca tgccgccaaa 3228121 aagggcgaaa ttcagcaaaa acccgataaa ttgggcagct gagaagcggc cgtttttgta 3228181 taaggacgcc ggcaggatgg gtgtttttgc agaaatttcc cgcagcaaaa acagcacaaa 3228241 tgccaaaacc gctgcagtaa atgctacaag aatcactggc gagcgccagc ccgctgaagg 3228301 cccctgtatc aaagcatagg aaagaaaccc gagagccatc atgccaagca gatgcccgat 3228361 gatgttcacg cggctgcttt tcccaggaac gcggctgagg attcggtaag ctgaaatgag 3228421 cgcagcagcc cctattggca cattgatcag aaaaatactc tgccagcccg ccaactgtac 3228481 cagcacgccc ccgataaaag gcccaagggc tgaagcggcg gaaacaagcg cggcccacag 3228541 tccaaacatt ctcgcccgcg cccgctcatc aaggtaagag gcagccaaaa ggctgagtga 3228601 gcttggcata aacaaagctg ccccaattcc ctgtatgaga cgtccggcaa tcagcatctg 3228661 cccatttata gatgcagcgc atagacagga ggccataaca aaaacggcta gacccaagat 3228721 atagatcgtc ttcgagccga aacggtcagc caaggctccg cccgccagca gaagcgacgc 3228781 aaaagtaaga atgtacccgt ccacaaccca cgttacacct gaaagtgaca ttgaaagagt 3228841 gtttttcata tcagccatcg ccacattcac aacggtcaca tcaagagttg ccatgaggaa 3228901 accaagtgcg agcacgatca gcacggatat gcctgttgat gatgttgatt cttgtataga 3228961 cccgctattt ttcattacaa ttgccctttc acttgcttga ttacccaatc atctattttt 3229021 tcaagatcat acaattcccc gactctgtcc ataacatgct gcaaggattc ttctctcata 3229081 agattggacc atttatcctc gatttccgcc atgactgtct ccagcacaca gtgactttca 3229141 ccctcaaata cagattgcag caagcctttc ccctgataca tcgaacctct gccttcgacc 3229201 gcttgataaa catcataaag cgtaatgtca gccaaaggct tcgtcagggt aaaaccgccc 3229261 ttcgtccctg gtaaggattc tgccaaaccg gcttgaacca atgttctcat cagcttcttc 3229321 aagtaagacg gagacacgcg caatcgctgg cttatagcct ctgacgtcaa agaagcctgt 3229381 accggcagcc gtgacagtaa cagcagcaca gaaaccgcct gctccattcc tgatttcatt 3229441 ttcatcctat tcactcctga ttcattatgg ataactatta tccataatga atctcttagc 3229501 agcttttgtc aataaaaaaa gcaaaagaaa cggatcattt cttttgcttg gtatggttaa 3229561 caaatctgct tcagttcctc tatgtattga agcgcttcgt catattcttc atttgtatat 3229621 ttttgcttgc ttttgatggt aaagactttt tctttctttt cctcatcctc aagcccgtca 3229681 aagtaaagga tcgtggaaac cagctctaaa aaccgtgatg aacggctgtt tacactgtcg 3229741 atatagcctt tcatatccgg catgtccaga tcagcatggt ctaaaaatgc ggagcctgtc 3229801 tcagtcagcg aataccggta ttgaaagtag ccgccctttt tttccttcac ctcatgcaga 3229861 aatccaaggt tgcacagctc ttcaatctgg agcgtcagtt cctctgaata tggtccgtaa 3229921 aagtgaaaat catatttctc atagaaagga aactgcattt tcttggcgat ataaatcatt 3229981 ttctgcagct tctttcgccc gatgatttct ccagaatccg agaacacctt catcagtttt 3230041 gcatgttctt tcaacaaatt cccgacatct cctttttcct tctttccaat ttctatgtca 3230101 gtcccagcag ctgccggatt ttcattttcg cttccggatg tttagtgccg tcacaaatca 3230161 agtcctttgg atagtacagc ttgtggtccg tccgccgttt acctgagatg gattccacaa 3230221 tagccgactg tctggacagc tctttaattt ggccgttttg cgtcaagaga tggatcggca 3230281 gacgctcctc ttcctctcct ggtcggtaaa aatcgtatgg cagatctgat gaagaatcaa 3230341 cgaccaaata atagctcgga tcgatccccg cctctttgaa caatgaagtc agctcaaaat 3230401 aagccgacat ttcttcattc ggattgaatt caacgtattg gaaaagctgg cggttaatga 3230461 atctgcggca caagtcggat aaaatcgcgt cttcttcatc ctcccaggcc tggaagtaat 3230521 acaaaataat agattcatcc agctttacat aatcctccag tgtcaatttt ccttcaaaaa 3230581 tagaatagaa atgaaccgga gcgtgagtga agacatagcc ttcatcgtgc agctgcttcg 3230641 ccctgtgaag aatcttcgtt aaaatgacct ctgcacttct agtcacagga tggaagtaga 3230701 cctgccagta catttggtaa cggctcatga tatagtcttc gacagcgtgc attccgcttt 3230761 ctttaatgac gatctgatcc tcgcgcggcc gcatcacccg aagaatccgc tccatatcaa 3230821 aatggccgta gctgacgccc gtataatatg cgtcgcgctg gaggtaatcc atgcggtctg 3230881 cgtcaatctg actcgaaatc aggctgacca cttgcttgtt tttatatgtt ttggcaatga 3230941 cttcagcaac atcctgaggg aaacccgggc tcacctttct gagcacctga ttaacctccg 3231001 tgtctcccaa aatgatacct cttgtaaaat cctcgtggtc aaggtgaaag accttttcaa 3231061 atgaatgcga gaacggcccg tgcccgaggt catgaagcag cgccgcggcc aaacagagtt 3231121 cgcgctcact gtcatcccat tcagggcggc ctttaaagac gtcatcaacc attcttctga 3231181 caatttcata gacaccgaga gaatggttga accggctgtg ctcagcccca tggaacgtca 3231241 aataggtcgt tccgagctgc ttaattctgc ggagacgctg aaattcacgg gttccgatca 3231301 aatcccatat cagcttgtcc cgaacatgaa catagcggtg caccggatct ttaaacactt 3231361 tttcttctga taattttcca tttggatacg ccatcgtcat tccctctttt ttttagccgt 3231421 gtttctatta tatcgactct attctttgaa aacatccttg aatttgcccg gcgatttgtt 3231481 ccatcttcat gaaaaacaca tcttgtgaag caaaaaagcc tgacctgagg gccgaggcta 3231541 agaaaaaata tgtttttact tttttatttt cttttttact ttgtcaatca gctcatcctc 3231601 tgtcggagct gacagcgggc gattgttcac aaaagcaaat gattttttcc gtccgggccc 3231661 gcaataagat tggcatccta cctcaacctt tgcgtccggg tccacttctt tcaaacgcgg 3231721 cagcaatgtt ttgatattag tggcttggca atcatcacac actcgaaatt cattagccat 3231781 gacgtacgct tcccttcatt tctatgttca tctatgtgaa taacctaaaa tcacgtttca 3231841 aaaaaaatca catcacactt cattttacaa ggattcgact gttcctgcaa gccgctccat 3231901 ccttcgtatc tcctattctt tcagccaatt tgtataaata ttttccaacc tggacattct 3231961 aataccatga aaagaaaaat gggagttgag ataaatgaca aaacagcgac aagacgcttg 3232021 gtcagaggaa aacgatctgc ttttagccga aacagtgctt cggcatgtga gggagggcag 3232081 cactcagctg aacgcctttg aagaagtcgg cgataaatta aaccggacat ccgcagcctg 3232141 cggattcaga tggaacgcag tggtccgcca tcaatatgaa aaagcgcttc agcttgcgaa 3232201 gaaacaacga aaacagcgga tgagagcgct cggaaacggg cagcccgcga aaaaaagatt 3232261 attatatcag cctcctgccg ttgatcctga aatcattcaa gaaaccgctg cagaagagcc 3232321 ggttaaaacg gaaacaccat ctgtcgaaaa tgagcaacct ttaatgtctg gcgaacacat 3232381 gccttttgtt gatgaaagct ttaaggaaga gttagctagt ctatcacact tattgtctcc 3232441 tcaaacgcct gcagctgcgc ctgagatgac gatgaatgat gtgatccgct tcctgcagaa 3232501 ttacgaaggc aatcacgagc aatcatcagc attaaaaatg gaaaacgagc gtttaaagaa 3232561 agaaaatcag gaattgcaaa acaaaacaga gcagctagag gcagaagttc aaaagcttga 3232621 aaaagaccaa aaaacgatcc aagaagatta tgaaaccttg gtgaaaatta tgaacagagc 3232681 cagaaagcta gttttatttg aagaagatga acatgcctct ccgtccttca aaatggaccg 3232741 gaacggcaat ttagaaaaat tagcggaatg acatagaaaa atcccaaaac gggcagctgt 3232801 tttgggattt tcgccatgtg caaaatcccc ttttctattg agaaaagaga atttcctcat 3232861 tttgcagccg gatcagctat tcttgtaaaa tgaggccaag cttatgtgaa tctattaaga 3232921 catgtgagct gcctcggccg ttttttgttt ccgaggcgca gcagaaatga ccaaaagccc 3232981 cagcatcata agcgcaatgc ccagccacga ggaaggcgaa agcatttccc ctatgaaaaa 3233041 cacgccaagc aatgaagccg tcagcggttc agctaaagac agcgtgaccg ccgccgaggc 3233101 cggaaccccg gtaagccctt tcgcaaacaa aaagtatgcg gcacatgttg caattaaccc 3233161 gatgtaaagg cttgttccca gtcctctagg ggtcaatatc cacgagatat ctaactgcca 3233221 taatagcggc gtcagcaaga tggcgctgat catgaataca acggcggagg tcgctcgcgg 3233281 aggctgggtt ttcatcatcg ctttactgat gagcgtatag cctgcaaaag aagcacccgc 3233341 tccaagcgcc ataagaacac cagccacatc aatccgaaca ttggaactgt cggaaaacag 3233401 aagccagcaa cccgctaaag ccagcacagt cgcaatccac caggagtttc gcgggcgttt 3233461 cttcaataca gcccattcga gggtcccggc aatgataggc gcactgccga tggcaatcac 3233521 agttcccact gcaattcccg tttctttaac cgctgtgaaa aacagcggct ggtaacacgc 3233581 catacaaaca gcggctaaaa atacgagcgg ccatgcccaa tttttcacgt gaagctcccg 3233641 gctgatccaa accgcaagca gcatggcgct tcctcctatt aataacctga acgctccaaa 3233701 tgccagcggt gtggcgcttt ctggagccaa tgcctgaacg gttcccgtgg tcccccagaa 3233761 aaaagccgca atcaatacaa aaaggctgta aatattcccc ttcatctgcc tctccccttt 3233821 aatatggatg ctgatgtcat tttatcgttt ttctttttgt cgtggttatc tgtatgtaag 3233881 aaggacttat ctgaaaataa gattattgag gtaaaatgcc gcttgagata aaaaatgcat 3233941 gccggcatat acagccggca tgcgaagaac gttcacccaa atacctttgc attccgctca 3234001 gccatccgga cgaggttttt ctcaaattcc atttcctcat caatggacag tccagctgaa 3234061 taaagatggg tgcttaacgc ttttaattcc gtcaataaag cgaacattaa gtcttgtacg 3234121 gagatgtctt tttgaagaag ctcacttaag gacgccatcg tttccggacg tatttccgga 3234181 tagacgcctt ttttatcgtt ttgtttgtct ttcagcgccg cttgatagaa tcgtctgatc 3234241 aagtcggccc tttcactgcc gcttttatct gcacagagat aaatttgaac agcgactccg 3234301 ccgcgaacgc gtctctgaga gatgccggcg aactttttgc catttatact gaggtcatag 3234361 ctgccgggac aataagaccc ttcaatttca taggcttcga tctttgcgtt gtacggtctc 3234421 agcattcgtc tcatcagctc gaccatcgct tcatatcctt tgtctatatc gatgcctttc 3234481 ttttcgtcct cgaatatgag agagatattt aaaacaccgt catccaatac gacggcaaga 3234541 ccgccggaat tgcgtacgat cacacggtat ccttcgctct ccagcaagga gataccatcc 3234601 tgcaaaaacg ggaggcgtgt atcctgtatt ccaaggacaa ttgtatcgtg gtgcacccat 3234661 gagcgcgctg tcgccggcga cacgcctttt ccgacggaca tgcatagcgt atcatccatt 3234721 gcgaaggatt gcttcgcatc aaataaaggg ccgagactgg attggtcaat gactctccat 3234781 ttcggctgca tcagtaaatc aatcggttgg tttgccatct atgtaaaacc ctttcatgtt 3234841 aggcttattg aacgaaaact attatatcat ttcagcagct gtgattgata attgcttttc 3234901 agcatcgtaa taaaaatttc tttatttttt gtattctcca tgagaggaga atgaatgtaa 3234961 gacagcttgc gctttaacga gaaattatta atatgcagaa ttgaaatttc gcggtggatc 3235021 aaatccttac gcagcacgct tctggataga accgaaagtc ccatgccgtt aatcaccgct 3235081 tcctttacac cttgattgct gctgatggta aacattgatt tcggccgaag tccatttgaa 3235141 ctgagtacat gatcgagata ttctctcgtc ccggagcctt tctctcttgt cacccacgct 3235201 tcgttctgca aatcgctgat cgaaatctct ttccgcccgg cgagcggatg ctgatttgga 3235261 gcggcaatgc acatttcatc ctccatgaac ggttcaattt ccagctcatt ctcgtttgta 3235321 tgtccttcaa tcagcccgat atcagcctga agcatccgca cacgctcgct gacctcctct 3235381 gtattgccaa tcatgacatc tagattcagc tctggataca gcttttgcag ctgggccaat 3235441 agcggcggaa gaatatactc accgattgta aagcttgcag ctattttcaa ttcacccttc 3235501 acatagtgat gatgcgcata gatttcagcc ttggcttgtt cgtagagaaa caccatttgc 3235561 tttgctcttt gatataaaat gtctcctgtc ggcgttgtcg taaagtgttt tggcgacctg 3235621 ttcagaagag ccgtttgaaa ttctttctca agatttttga tatgcagact gacgctgggc 3235681 tgggagatca tcagcttttc cgccgctttt gtgaagtttt tttcttctac caccgctata 3235741 aacgttttca gcacgtcgta atacaaaaac cccacccctg tcattaatga aatatatggt 3235801 tatgattagt tttctttatt gtactcatat catccgtctt ggtaaagaag ggctatacag 3235861 aagcgcaaaa aaggcagccc tcggtcgaga gctgccattg tcttcaattt tattacagtg 3235921 cttgcgccgc tgtaattaat gcgagattgt aaacatcttc agcgttacat cctcttgaaa 3235981 ggtcgtttac aggcatattt aaaccttgca ggattggtcc taccgcttca aagttgccca 3236041 aacgctgagc gattttatag ccgatgtttc ctgcttcaag acttgggaat acgaatacgt 3236101 tagcgtcccc tttgatctcg gaatccggcg cttttttctc agctacagat ggaacaaatg 3236161 cagcatcaaa ttggaattcg ccgtcaagtg tcagttcagg cgctttttct ttcgcgattt 3236221 tcactgcatc cgctactttt tctgtttcat cagattttgc tgagcctttt gtagagaagc 3236281 tgagcattgc cacgcgaggc tcaatgtcga acatttttgc cgtattggca ctttcgatcg 3236341 caatctcggc aagatcttgg ctgtcaggtg caatgttgat cgcgcaatct gcgaatacgt 3236401 attgctcttc tccgcgagcc atgatgaaca cgcctgaagt ctttttcacg ccttcttttg 3236461 ttttgatgat ttgaagagcc gggcggacag tgtcagcagt tgagtgagca gctccgctta 3236521 caagtccgtc tgcaagtcct ttatacacca gcattgtacc gaagtagttc tcgtctaata 3236581 atgctttacg agcctgttct tcagtcgctt tgcctttgcg gcgttctacg aatgcttgta 3236641 caaggtcttc catgccttca tatgtatgag gatcataaat cttaacgccg cccagcgtaa 3236701 ggttcaattc ttttgctttt gcttggatct cattttcatt gccgatcaca atcggattca 3236761 gcactttgtt tcctgcaagc ttgctgaccg cttctaaaat acgctcgtct aagccttcag 3236821 gaaatacaat tttaacgtct tttccagcta ctttttcttg cactgttgaa aataaatctg 3236881 ccacaataaa acctcctcaa aaagttacaa aaacgctttc ttttactagc atactcttct 3236941 tccaatcaaa ttcaaacagc caactttcat tatagcgctt tcataaaaaa atcttatttt 3237001 tctaactaat ttaagtgact caatcttccc ttataggttc ttctattttg atggagttat 3237061 acggaaggga tgttcaaggt ttctccacag tagaatcgga taaactatgg tatagtgaag 3237121 gcaatcatga aaagataatg ggagtgaaga taaatgagtg aacagcaaat gacgaatgaa 3237181 gcggcaaaaa cgcttgacgg ctggtatgcg cttcatgatt tccgcacaat ggattgggct 3237241 tcctggaagc ttctgtccag tgatgagcgc caatctatca tacatgaatt caccgggttg 3237301 cttgaaaaat ggggcgtagc ccaaaaagaa ggaaaaggat cgcaaactct ttacagcatc 3237361 gtcggccaaa aagctgattt tatgctgatg atccttcgtc ctacaatgga agaattaaat 3237421 caaattgagc ttgaattcaa caaatcaaga cttgctgagt tcaccattcc ggcatactcc 3237481 tacgtatcag tggtagagct gagcaactac ttggcaagcg gtgacggcga tccttatgaa 3237541 aatccgcatg tgcgcgctcg cctttaccct gaactgccgg aatctaaata tgtatgcttc 3237601 tatccaatgg ataaaagaag atctggcaac gacaactggt atatgctttc aatggaagaa 3237661 cgcagaaact tgatgagaag ccacggttta atcggccgca gctatgcggg caaagtcaaa 3237721 cagatcatca ccggctctgt cggctttgac gattacgagt ggggcgttac attatttagc 3237781 gatgatgtcc ttcaattcaa gaagctagtg tacgaaatgc gttttgacga agtcagcgct 3237841 cgctatggcg aatttggttc attctttgtc ggcaatcacc tttcgcttga tacacttcct 3237901 caattcttat atgtataata tccccgagct cgtttattga gataaggact gatcggcctt 3237961 ctgctcaagt ttgccgtact ttttatatgc gaatacactg agcacaaatc cgaggactgt 3238021 gatggcggcg caaatcaatc cgacagctgc atagccgtat gccacatata cgggtcccat 3238081 taaagcagaa cctaatgtca cggccagatt cgaggcgaga ctgtaaaaca ccatgacttt 3238141 tcctcgatga cgctctgagc agtcactcaa aatggtgctg agcagcgtca ccgtcaaact 3238201 ttgcattaat ccccaaataa ataggctggc gattaacaga aacatagacg ccggcgcata 3238261 tggtaaacac gccagcagaa cgctgatgac ccccagcgca atcaaaaggg agcgcatttt 3238321 tccgatgcgg tcggctatct ttcctgtaat cacactcatg gaaaacccga ttccataaat 3238381 catgataaat aagcccgcag ccgtgtttcc tccggtaaaa acgtcctgaa gataggtgcc 3238441 taaaaaggaa tacataccgt aaaaaccaat catattacaa aaggttattg tgatataaac 3238501 aggtacacga gggactttca gcgcatcccg gaatgttcct gcgggctctt ctatttcttc 3238561 cttgccgctg tttttatgtt gggcatggcg gcgcatttca aggagaatca gcagaacaac 3238621 taaaacaccc atcagggcga aaatccaaaa cgtccatctc caatgcagga cgccgccgat 3238681 aaatgatccg agcggcactc cgaaaatcag cgccagcgac cagcttgaaa cgatcagtcc 3238741 catcaccttg ccccggtatg tataaggaac acgatcaccg acaactgcgt aagcggtcgg 3238801 aacaaacgct cccgcagcca atcccgaaag cgcccggcct aaaaagaaga aaaaaatatt 3238861 ttgagctaaa gcgcatatca ccgttcctat gataaaaatc ataagcccgg ccaataagct 3238921 cagttctctg gagtatttat cgcctaatgg aaccaaaagc ggcgcaccga taaaaatcat 3238981 aacgccgtaa atactgatag ataacgcaag gacgctgaca tctgagctga aggcttttgc 3239041 taaatccggc agcagcggtg agatcacaag ctcttcagat ccggctgcaa atacccccat 3239101 cgttaaagcc agtgccaaca ataacggaaa atgatgtttt gttttgatgt cattgttttg 3239161 attgctgttc attctttctc aaacacctct tccataatct tcttatcata aagttgtatt 3239221 atagtttagc attgtttttt ctctatttac aattcgaacg aaatatttat aagttttatt 3239281 attttcattt aaatcccatt atatatttct atatttcatt ctaaaaatac atgaggatgt 3239341 aacacgtaaa aaaagctctc cggcctcccg gagagctttt tctattgcgc ctctgtctgc 3239401 tttttttcaa tcgtttcatg atttatacgc tttttgatgc ttagatgata gtatgcataa 3239461 cagaaaataa tgatcggcac accgcagtat aagccaattc tttgatccgg aatgaaaata 3239521 aggctgatca acacgcagcc atataaacaa aatccgagaa tcgggactag cggataaagc 3239581 ggcgttctga actccagatc attcacattt ccgccttctg ccaggaaacg cctgcgaaag 3239641 aaaaattgcg acgcacaaat ggacatccac gcgacaactg tcaccatgcc cgagattgag 3239701 atacaccata aatacactgt ttctgcagcc atgacacttg tcagcagcga acagcctgaa 3239761 atgcctagcg taatcagcag ggcattcatc ggcacgcctt tttttgtcag tctggtgaga 3239821 aaggagggac ccatttgatt tgatgaaagt gaccacatca tacgcgacgc cgcatacaat 3239881 cccgaattag caacagataa aatggccgtt aagatgacaa agttcatgat atctgccgaa 3239941 aatgggatgc cgatttgatc gagtactgct acaaacgggc tttcaatcac ccccgccgtt 3240001 ttgtacggaa ggatggcaac caagacgaac atagcgagca caaagaaaaa cagcgtgcgc 3240061 caaataacat ttcgaatgga ctttggcagt gttttttccg ggctttcact ttcccctgcc 3240121 gcaatgccga caagctccgt tccctggaac gagaagttta ccatgaccag cgtaaacata 3240181 acggccagca ccccattagg gaaaagccct ctatcagtca taaagttaga caaaaagggt 3240241 gtctcctgtc cgcctttaaa gtcaatcaag ccaaacacag cggctccgcc aatcacaata 3240301 aataatatga tcgccgccac tttgatgctt gaaaaccaaa attccatttc cgcaaagctt 3240361 ctgacagaga gcgcattaat caaaaagatg acgatgccga acacgaggca ccatatccag 3240421 atcggaacgg agggcagcca cctttgcatc aaaatgcctg ctgacgtcag ctctaaccct 3240481 actgtattgg cccagctgaa ccaatacagc cagccaatca taaagcctgt cgactgtccc 3240541 agaaatttag tggcgtaggc ctgaaacgat ccggccaccg gcatggcaac agccaattct 3240601 cctaaacaaa gcatgacgag atacattaaa aatccgccga tgatatacgc ggcaatggcg 3240661 ccgagcggtc ccgcctggct aatggtaaag ccagagccta gaaacagccc agtgccaatc 3240721 acccctccca aagcaatcat aaacaaatgc ctgcttttca tgctgcgctg caattcattt 3240781 ttatgattct gcatcatcct tccccctttg gttcttttgc cgtgatggtc atccggtagc 3240841 tttgcaaaag atgaacggtg gtttgctgta tgaggagagg caatacatga aatgtgtacg 3240901 gtttatagac tcgttctgtc catttatggc cgtcttttcc gtacacgccc atattaatgg 3240961 atggaatatt cagcttgcgt atgtctttga acggaatggt cccaatcata ttccacccag 3241021 ggaagttcct gataaaagaa tcaatttcgc catcggtttc gtgcagtgat aaaaaactgc 3241081 cgtctgccaa gtaggggaaa aactttttga agacaaatgt ttcgcctgtc gattcagcgg 3241141 ttttgtcagc cgcttcttta atcacatgct gcaaaagctg atctcttgcg ctatcttctt 3241201 tcaaatagtt atgcggcagg taaggaggtg cgtaaaatag aatgactttt gcgccttgat 3241261 cggggtcaag cttttgaagc tcttcgattg cctgaaagca tctcatgcga agttcaaggt 3241321 gctcgttggc tttgaatgtc tgctcgatac actgctcggg atctattccc cggtttctca 3241381 gcttttctaa gtattgctcc aggctataca cttgaatgcc ccatgataaa tgtttctttg 3241441 gcaggttggc tctttttaca tattcttcgt aataatctga taatttttgt tctgtctccc 3241501 ggcatgcttc ctcagtgact tcaataagca aatccatcat ttcttttgct gttctttcat 3241561 aaataaaaca attgaaatac aagctggtgc tgacagccgt ttgcacatta taggattcct 3241621 tgttatcacg ctgatacaaa caggatgggg gcagaaccaa ctccccttca accttttctg 3241681 ccagatggat gttattgtgg agacggcttg tgatttcaga tgaaatgaaa tttgggtcaa 3241741 tccctgccag tgtatcgcca acatggactt cacgcccgta aatgtaaaag caaggcaaca 3241801 gttttcccgc ggctccggta tagatatatc ttgtctgatc accatcgtaa agcggggtaa 3241861 taaaatccgt attaatagca gccaaatagt gaagctgttt ttcttttttt agccggttca 3241921 gctctgaaat gctggcgaga atgcccgaat gctggctctc ctcatcggga ttggccataa 3241981 acaatacatt tcccggcaac gtctcaaggt tctccgaaaa atgcaggaga ttggctaaat 3242041 gcacggcgat gccgctttgc atatcgacag atcctcttcc gaacatccac tcgcctgatt 3242101 tggcatcccg ctgaacatcc tgatcgaact catagcggct gaaatactcg gccaatttct 3242161 cacaatcaaa agcgatatcc tttaaagggc cgaaatcttc aattccaact gtatccagat 3242221 gggcatggta aatgactgta tttcggcttt ctccatgtcc tttaataaac gcaaaaatat 3242281 ttttgcgttt gtatgggtca ttgggaatgg cctgttccca cacatgactg gggttttcct 3242341 gaaaataagg atagctcgtg atcacttctt tgatgaaatc tgcttttgtc ccttctccaa 3242401 cggtgccgtt cacgctgctg aggctgacca gagatgctgt cagcgcctcc actctttcag 3242461 ccggattcat gtgactgatt tttgtatact gcataaattg tcctcctgat caaaaagttg 3242521 aaatcgtgcg atccgctaaa gaatcgcacg attttatttc tctcaaatca aaaagcttcg 3242581 gacgttgttt tggcttgcat atgaagaatt aagtaatcgg gaccgcctgc ttttgagtct 3242641 gttcctgaca tattaaaacc gccgaacggc tgatagccga caattgctcc ggtacatcct 3242701 ctgttaaaat ataggtttcc gacatggaaa tcctcgcgcg cccgttcaat gtgcgcacgg 3242761 tttttcgtca gaagcgcacc tgttaatccg tattccgtgt tattggcaat ctccagcata 3242821 tgatcgaaat cacgcgcttt gcaaatcgca acaaccgggc cgaaaatttc ttcctgcatc 3242881 aagcgggcgt tttcatcaac atctgcaaag atcgtcggct gaataaagta gccttttgaa 3242941 tcatcgcctt ctccgccggc caatagcttg ccttcagatt tgccgatttc aatgtatttc 3243001 atcactttgt tgtaggatgc ttcatgaatc acgggaccca tatacgtatc aggatcttct 3243061 ggattgccga cagtcagcgt tttggtcagc gccacagctt tttccaccac ttcatcatac 3243121 acatcctgat gaatgaccgc gcgggagccc gcagaacact tctgtcctga atatccaaat 3243181 gctgaataca cgatagagga tgcagcaagg tcaagatcag cgtccttgtc gacaagcact 3243241 gtgtcttttc cgcccatttc tgcaattacc cgtttgagcc atttttggcc cggctgcact 3243301 ttggcagctc gctcataaat ccggcagccg actgcacggg aacctgtaaa tgagacaaac 3243361 cgtgtcttcg gatgctcaac taagaaatca ccgatctccg caccatctcc cggaatgtaa 3243421 ttcagaacgc cgtttggcag acccgcttcc tccatgacct cgacaaattt tgctgccact 3243481 accggggctg cgtcagccgg ttttaagaga atcgtatttc ctgtcacaat cgctgccacc 3243541 gctgttcccg ccataatcgc gagcgggaag ttaaatggag aaatgacgat gccgacgcca 3243601 agcgcttcgt aatgatattg attgacctcg ccagcacggc tcttcaccgg agccccttcc 3243661 ttgagcttta acatttggcg cgcgtagaac tctaaaaagt ctatcgcttc agccgtgtcc 3243721 gcatctgctt ccttccacgg ttttcctgct tccttcacaa gatagcttga aaattcatgc 3243781 tttcttctgc gcaaaatagc cgctgcctta aagagaatat ttgcgcggtg ctccggtctt 3243841 tgttttttcc aggaatcaaa tgcctgcaat gcggcttgca tcgctttttc agcaagctct 3243901 tgatccgctg tagacgcgta cccaatgatc tcttctttat ttgccgggtt aatagaaatg 3243961 attttgcggt ccgtttcaat tttttctcca tttatgacaa gcggataatg cttgccgagc 3244021 tgagtgttta caaaggccaa tgactcccca aatgcagttt tattctttgc ttccgtaaaa 3244081 tcggtaaatg gttcgtgcgc gtatgtgact gtcatatgta gtccccctcg tgttatgaaa 3244141 tatatcttcg catatgaata aaaatgcaag aatcatgcca ttttcttgtc ttttgctgaa 3244201 aaaacttgtt gaatcgaaca gaaatttgtc taacaggtga tcacctttct ctttttccga 3244261 tcttgaacgc aaatttattt tgcgtttttt gctctttacg caaaaaacaa atgcaaaatt 3244321 attttgcgga ggcttctcaa attagaccca tccgcggaaa cgcgatgctt ctgccgattt 3244381 tctgatgccc gtcatgtaag ccgccaaacg catatccact ttatgtgttg ccgctgtttg 3244441 ataaattgtt tcgaacgagc tgaccatgac gcttctcagt ttttctgcaa cctcttcttc 3244501 cgaccaataa tatccttggt tgttttgcac ccattcaaaa taagaaaccg tgacgccgcc 3244561 ggcactcgct aggatatccg gcacaagcag cacgcctctt tcattcagga tcttagtggc 3244621 atcaatggtt gtcgggccgt tcgccgcttc aacgacgatt gacgcctgaa tgttatgtgc 3244681 gtttttggct gtgatttgat tggagatcgc ggcaggcact aaaatatcgc aatccttttc 3244741 aagcagctcc tcatttgtga tgacgtcagt aaataaattg gtgaccatac caaagctgtc 3244801 ccgtttatcg agcaaataag ggatatcaag gccgtctggg ttgtagagcc cgccattggc 3244861 atcagaaatc ccgatcacct tcgcgcccgc atcgtgcatg aatttggcca ggaagctacc 3244921 cgcgtttcca aagccctgta tgatgatgcg cgcgttttgc agcttgatcc cttttttctt 3244981 caccgcctct tcaatacaaa tcgtgacgcc ctgtgccgtc gctgtttccc gtccttgcga 3245041 tcctcccaaa acaagcggtt tacctgtaat aaagcccgga gaatcgaatt cccgcagccg 3245101 gctgtactca tccatcatcc acgccataat ctgcgaattg gtgtacacat cgggagctgg 3245161 aatatccttt gtcggaccga cgatctggct gatggcacgg acataccccc tgctcagcct 3245221 ttccagttct ccaaatgaca ttgtccgcgg atcacaaata ataccgccct tcccgccgcc 3245281 gtaaggaaga ttggcaatcc cgcatttgag cgtcatccaa atggataatg cctttacttc 3245341 ctcttcatta acttctggat ggaagcgaac gccccccttt gtcggaccga cagcatcatt 3245401 gtgctgtgac cggtagcctg tgaacacttt gacgctccca ttgtccattt tgaccggaat 3245461 gcggacagtg agcattctct gcggctcttt catgagttca tacatatctc ccggataacc 3245521 cagcttccga agggcttcct taatgattgt ttgggtagac agaaataagt taagagcttc 3245581 tttttcttca tctttcgaga cttgctttgc tgacatcttt ttcacctcat tgtttttttg 3245641 gccggctgta atgtaagcgc tttaaaaaat cagcccgcca attcctttct tcattggatt 3245701 cacccttatc atcatgcaag atccgtacca gcttttgaat ccacaaaaaa agagactgaa 3245761 aacatctcag tctctgacta caaatctatc gattaacggg gatcaatcac cagctgcgtt 3245821 tcagcataaa aactgccgat tcccaaaccg tttactacat cgcctttaat cgtgtaagtg 3245881 cctgcgcgag gaagagtttt acgcaccatg acaaggtcaa attcggatgc gcctaacaaa 3245941 tcaagcgtaa gcgggagtct gactgttttt ccatcgttta aaatctgtgt ttctttcagt 3246001 gttcttccat tcactgaatc tcttgtcgta gcatgaaacc cgtcaggaaa ttgaaattct 3246061 accgctccaa gagaaagcac cgcatttggt ttatatgtca cttcaatatc agaaatggtc 3246121 cactctttcg tgctgttaac tgtttttgcc tcgattgatg cagactgtgc atgagcttgg 3246181 cccgaaggaa gtaagattga tagtaaaaca gctgaactga tgaataatga agatacgaat 3246241 gaagttcttt ttagcatgac atttccccct aattgattgt tgaaatttgg ccagagcgtc 3246301 ctctgcagaa aaagcgcttt ttcataattc gcgaattacc agttcttttt cttaaaaatt 3246361 aatctatcat cattttccat ggaagtaaat gttttttaag gaatattaac acttggaatt 3246421 caatgagaat tccttcctgt ttatacaagg ttcaaatgga cgatttccct ctctttttct 3246481 agtaacatct gcctgacatt ttatatcttt tatcctattt taaaaaaggg caaaaaaagt 3246541 cgaagatgcc tctgctcttc gattgatcac gttcctattt ttatctgaat tcagtgttcc 3246601 agttaaaacc gatcgtctca tcatcccacg gaattctttt ttcatcaggc tgatccgggt 3246661 tatacgacat ggtggtaaaa tagataattg tcagcggcgt ctctcccagc actctatatc 3246721 cgtgagccac cccttttggg attaataaca gcatcgggtt gtcttcgccc atataataga 3246781 cgtccgtttc tccttttgtc tttgaatcct ctcgaagatc gtataggaca acctgagcgt 3246841 ggccggttgg gaagaaccag agatcatcct gcttctcatg ataatgaaat gccttaatca 3246901 cacccggata gcttttcgac caagaggcct gcccaaaatg ctcaaggaga ttctcatcgt 3246961 cccggaccag ctcagcaaaa aagcctctgt catcgctatg cttcatcaat tttttcacct 3247021 tgactccatc aatcacacgc actgctcctt tcctgcaaat actctcgtaa cgcttcccgc 3247081 cagtggcggg ggcggatgcc ggcttcttca atagcccgat ggctcagcac agagtatgcc 3247141 ggacggggcg ttttgttccc gtattcctct gtcgttacag acaaaatggc tgtttccagc 3247201 ccgctttctt ccataattgc cgtcgcaaac tcataccagc tgcatatgcc tgaattgctg 3247261 acatgataga tgcccggcgg atggctgaac agcttgatga ccgcttctgc taaatccttc 3247321 gtataagtcg gcgaaccaat ttgatcgctg acaacccgaa gctcttgttt cgtttcagca 3247381 agtttcagca tggtttcaac gaaattactg ccgccatgtc cgtacaccca cgatgtcctg 3247441 atgatcgtgc tgtcttttgt cgttaatcgt atcagttctt ctccgagcct tttgcttttg 3247501 ccataaatgg ttttcggatc gaggggatcg tcttccctat atggctgggt tcctttccca 3247561 ttgaatacat agtccgtgct gatatgaaca tattgagctc cgatgcgggt tgactcaagc 3247621 gctgtataat aagcgccgat tccgttaatc aagtacgctt tatcaagctc tttctcgcat 3247681 tgatcaaccg acgtaaacgc ggcgctattg accacgatat ccggctgata atggccaaac 3247741 gaatgccgta ctgagcgctg gtcagcaatg ttcatcatct tctttgttaa cgcaatgacc 3247801 tcatatccgg cttgcttcag ctggcggcat agttccaagc caagctgtcc tcccgcccca 3247861 gtcaccaata cctttgtcaa tcagatcacc ttctcatcgg tcattgtctg tataccactg 3247921 aatcgtacgc gcaatgcctt cttcaaacgt cacttcctgc cgccagccca gttcgttttt 3247981 cagctttgat gcattgatcg catagcgccg gtcatgccct tttcggtctt ccacgtgggc 3248041 gaacaattcc tcacagccca gatgcttcaa aatgacactc gccagctctt tattcgtgcg 3248101 ttcatttccg ccgccgatgt tatacacctc gccgtcggtc cctttttcta aaatcagctt 3248161 gatcgcgcgg caatgatcct ccgcaaacag ccagtctcgg atctggagtc catcgccata 3248221 cagcggaaca ggcaggccct gcttcgcatg acggataatc gtcggaatca ttttttcgct 3248281 gtgctgataa ggtccgtaat tgttgctgca tcgtgtaatg atggccggaa gcttgtgggt 3248341 tttcacataa gacaacacga gcaaatcaga gcttgctttg ctggctgagt atgggttatt 3248401 aggagaaagc ggcgtcgttt ctgtaaacgc gggatcatcc gcttttaaat ccccgtatac 3248461 ctcatctgtt gaaatatgaa tcagcttctt ggcttttcct ttcaagaccg cttccgccaa 3248521 tcggtatgtc cccatgacat ttgtggtgat aaacggctcc gcttgggaaa tgcttctgtc 3248581 cacatgcgat tctgctgcga agtgaatgac gccatcgtag gtctcgtcaa aagcgcggtc 3248641 gatatcctcc tgaacgctga tgtccccttt tacaaagcga aaacggctgt tttgctttaa 3248701 tttttccatt tcctccgggt ggctggcgta cgtcagttta tctaaaacgg taatgcgcgc 3248761 atccgtttcc ctcagcatga gctttgtaaa cgtgagcccg atgaagccgg ccccgcctgt 3248821 aattaaatat gattttgcca tcacttttcg tcctgtcctt tccgtaaagc ctggtgtaca 3248881 agctgggaag cgagataaag cgattcgtga gttccggcat ctacccacca gcctgataac 3248941 acatcatacg taagctggct gttttcgatg tatagattat tcacatcggt gatttccagc 3249001 tcgccgcgct ttgatggtga tatttgttca atatatgaaa acacctctgc atcatacata 3249061 taaatgccgg taacacaaag gttggtcggt ggctgttcgg gcttttcgat gatggaacga 3249121 atccgcttgt ttttctcatc aatctcagca atcccgaaac gttccgggtc atcaacttct 3249181 ttcagaagca cttttgctcc tttcccctgc tgttcaaagc gttctgtata aggctttaat 3249241 gaatcttcaa atatattatc acctaataat aaaatgaaag actctttttt cgtaaagcgc 3249301 tttgcataag acagcccatc cgaaatgccc gatgctgccg gctgtacttg ataagtgata 3249361 gtaacgccaa gctcttcccc gttcccaagc agtttgtaaa attgcggcat atgctccttt 3249421 tggctgatga gtaaaatgtc ttttattccg gcttcctgca gcttcataat cgaccagtat 3249481 atcatcggat acgggcctac aggaagcaaa tgcttgttga cggctttcgt taagggcata 3249541 aggcgtgagc cgtttcctcc ggctaaaata acacctttca cattaacact tccttacatg 3249601 catttttata tctcttgttc atataaatct tgaagaatag ctgttacccg tataatgcct 3249661 ttgccatcca cgagcggcct tcctcccttg tgcaaagaaa ggcgaagagg atagctgctc 3249721 ataatgcgtg acatctgata gatgagtgtt tcatccggta caagctcacc caatccaaga 3249781 tcaagagcgg cgccttggtc agcaaatgtt ttggctgtag ccgtttgatg ctcaacctga 3249841 gaaagaacaa ggcacggcac gccgatgcaa atggcttcat atagagagat gccgccagcg 3249901 acaatggctg cgtccgcttg tttcatcaaa cctgccatat catttgtctg ttcgatcatc 3249961 ttgtactgcg gcttcttttc gatccgcctt cggactgcct cttgatgcgg tgaagcgctc 3250021 cccatcacaa acatcatgtt tttgtctttt atgtcgggga cttgatcagc ggcagccagc 3250081 actttaaaaa taagctgctt cggatcactt cctcctaatg caacaaggat attgcggcag 3250141 tctttcttaa gtgtgtaatc ctctcttgcg gcctgaaagg cggggtgaag aataagatag 3250201 tccggacctt catagatgcg tgtgtttccc tgaacgtaca ccctgcttct gatgtcaccg 3250261 taaattccgt taatgactgc gtcactatat tgaatcgatt taccgttttt ctcttcaaaa 3250321 agaacaattt tcgcatctgt ctccgtcttt attttcttta acagctctgc aggcgcgcct 3250381 agaatatcaa acaaaagcaa atcaagcttc ttgcttttta tttcccggag aataaattcg 3250441 tgctgctgca gctccggctt tacgatgacc tgccaatgct cttcatgaag aaacgcttca 3250501 gaatcctgat tcgtataaaa cgtaatcaag catcgctgtt tgagcccctc cgcaagcctc 3250561 ttcatccgga caacatggcc cattcccttt tcatagccgc cgtctgcgaa gatcccaaca 3250621 tgcatggcta gtcagcctct cgttcggttg ccgcatcggg gttccggttc agaagggtga 3250681 taagctctga ggcggataca tcggggcgct cgcctgcttt ttgatagagg gcctttatcg 3250741 attcatagtc ttcctttgta tcaatggtca gccgatattg aggggcgcga aatcgttccg 3250801 gcgcctctaa aaactgaaca cgataaagag ctggatgatt ccttatatat aacgtgacat 3250861 gctcctgata ttgatcctcc aaagcctgaa tacggctgat gtcaattaac aggttggcgt 3250921 tgaccacttc gccgcaaatc cctaatgggg cattcaggat atacgtataa tccgagcctt 3250981 gatcaaaatg cgcctgaatc attacatcga gcagctcagg atcgacaaac ggattatcac 3251041 ctgttaaccg gatgatgact gacggtttaa cagcttctat gaccttcaca aacctatcga 3251101 ggacacgttc ttcgctcccg cggaaaacac gaaagccttg tttgatacag tgcgcctcta 3251161 atatgtcgtc agtttctttg tcagacgtgg cgatgacaag attatcccga tccttttggt 3251221 aaaacgcgct ttgccggaca cggtgaacga gaatatcaag taaacgattc gatccgagcg 3251281 gccgaagcac ttttcccgga agccttgttg aacccattct tgcttgaatg ataaagagaa 3251341 tatcattcat gaaacgggct gtccttcagt aaaatgtcat cccagacaat gcctgtgtcg 3251401 gctggaatgt ctcttacagc ccgaacaccg ctggtcagca gttcaaaaaa tctcgggtgc 3251461 agcccctgcg gcttttgtcc gggccgaagc actgcgatat tgtcttcact aaaggcttca 3251521 cctttttgaa tcggagctgt tgtaaaaatg cctctgtatg caaagtttct gatttctcct 3251581 tcgatggcgg tcgttgtttt gtatgaactg ccaagcagtt tttcagagac cggctttgtg 3251641 atcccctgtt tcagctcagc ttccgttttc ctgatgccat cgaccatttc tttcaattca 3251701 tccggattta atgcaaacga gtggtcagca cccggcagat ttttatcgat cgtaaaatgc 3251761 ttttctatca gttttgctcc gagccgaacc gcggcacacg gcgcttctgt cggatgctcg 3251821 ctatgatcgg agaagccgat taccgcctca ggaaaagcgg cggcaagcat cggaatgacg 3251881 ctgaggttgc tgtactccgg cggtgctggg tatttcgcca cacaatgcat tatggcaatt 3251941 tgattgtttc cctctgccct gatggtgcgc caagcttcgt gaacatcaga gatttcagct 3252001 ccggctgtcg agaaaatcat cggcctgttc agccgggcga catatttaag cagcgggaga 3252061 tggttaattt cataggatgc gattttaaaa gcgctcggcg aggtagactg aagcagatca 3252121 gctgacccct cgtcacatac cgtacttaaa aagatcacct gcttttcgcg gcagtaatcc 3252181 aatagcggta aaatccactc agcaggcatt tccatagatt gaaccaaaga aaaaatagag 3252241 acgtccttgc ccgctgccgt cttgtacaaa ccaggatctt tctggtacat cctatcagct 3252301 tggaacattt gaaatttcac ggcatccgct cccgcttccg ccgcggcgtc tatcagcgca 3252361 aaagcctgat caagcttccc gtcatgatta atccccgcct cagcaataat aaaaacagga 3252421 gcgtctttgc ctacagtttt attcgcgatc tgaaacgctg ccattatttc gcctccttgc 3252481 ccggccaaat atgataatag taatacgatt gttcagcggt gaagcccatt cgttcataaa 3252541 ggcggatcgc ccttacattg tgaagctgcg tccccgctgt taccgttcta tgcttctggg 3252601 tctccggttg ttctatgaga ttcgccaata aatgaaacgc aatacgtttc ccttcaaatc 3252661 ccggctttac agccatcaaa tcgagaatgc actcatcatc tcttgataag ccctgaagat 3252721 agccgatgac ctcgccattg tgtttagcga caatattgac cgccgccctt ccattcagat 3252781 tgtttcgtgt ccactcctga aatatttcgt ttgctgcatc gcggctgaga tgaggatcct 3252841 gaaaatatct gctttttgta aacgagtctc gggccagctc acatatcgct tctgtgtctc 3252901 cgggctcagg cgggcccagt tcaaaaaatg gcggtgtttt gtcataaaaa gacggaggca 3252961 tcgccagctt cagcaaactc ccgacaaagt aagaggatgg ctgctgttgt atcacatgcg 3253021 cggctccgat atcttcagcc ggaacacgga caaagataaa atccgtttca tccatttggc 3253081 gtacagtata aaaagcttca aacagcctct ttagctgccc ggtactattt gccgcaagaa 3253141 gtttgacgtt catgactttc ttctgaagca ccttgctttc ccacaaagaa tcttcgtaaa 3253201 gcaatacgcc ttggagcctg ctgttttcaa aaaggccgag ggaaaattga tacggaacat 3253261 ccaatgtaag ctttctgctt tggagaaatt cctcaattgc ctctttggag acattttctt 3253321 ttaccgtata cacttaatca gcccctttta cgatatcccg cacagcttca atgacatcat 3253381 ctacatcatc gtcagacatt gatggataga gcgggagaga aagggttcgt ttatagtaat 3253441 tcatggcatt cggaaagtcc gcttccttat atccaaattg cttttgataa tacggatgaa 3253501 tgtgtactgg aataaaatga acgctagtgc cgatattgta ttcatccttt aaagccgtaa 3253561 tcatttcgct gcgcgtaacc ccggcctttt tttcatcaac ttgcagaaca tatagatgcc 3253621 aggcgtgcct gccgtcatca tggacaaacg gcgtgatcag cccaggaatc tgctgaaaag 3253681 cggtttgata gcggccggca atctcttctc tccgtttctg catatcatcc agccgtttca 3253741 gctgatgaag tccgagggcc gcctgcaaat caaacatatt catcttatag ccgggcgatt 3253801 cgacttcata gtaccagctg ccatttgaag aataacggtt ccatgcggct ttactcatgc 3253861 cgtgaaggct tagcacccgt atcttatcgg caagctcctc atcatcagtc gtcagcatgc 3253921 cgccttcccc tgtcgcgagg tttttggtgg cgtaaaagct gaatgccgtt gcatccccga 3253981 tagaaccgat cattctttgc ttataagtcg tatataccgc atgtgccgca tcctccagca 3254041 cgaataaacc atgattttgg gcaacagcca atattgcatc catatcgcag gactgcccgc 3254101 caaagtggac gggcacaact gctttcgttc gcggtgtgac ggccgcctca agctttaccg 3254161 ggtcaatatt gagcgtgttt tcgtcaatat ccgcaaacac aggcgtcgct cccgtatgaa 3254221 taatcgtatt ggcggtcgag ctgaacgtaa gcggagaggt aatgacctcg tccccgggcc 3254281 caatcccttt tgctttcaaa gccaaaaata aagctgcggt acatgaattc accgccacgg 3254341 cgtgcttcgc cccgacaaac gcggcaaact ctttttcaaa ctgctgaacc ttcgggcctt 3254401 tagagagcca tcccgattca agcgtttctg taacctcctg aatttcttcc ttaccgatta 3254461 acggcaatga gtaagggaga aaatgatttc tcttttgcac catttctttg cgctcctatc 3254521 attttattca gtatcttccc gcctgtaatc aacccctgtt ttggctttca gttccgcaaa 3254581 taaagcattt gttgattctg ccaccggata attagccgct atgaatgcca ggcgcgcctc 3254641 ttctgctttt tgatgcacgt cgggacttcg aagaacctca accaaggtgt gcgccagttc 3254701 atccggctgg tcaaacataa aatcgccaag agactcataa tacggatacg agcgatttcc 3254761 ggacgatttt cctatcagca caggcttttg aaacagcatg gcttcaagac cgactgtcga 3254821 ggtttgcgtc actgcggcat caacatacgg cagcaaatca taaagctcca gctccttttt 3254881 gatgactctg catgcttgat gttttttcgc cgcctcgtga tacagatcaa gcttgttttt 3254941 tccgatttcc cacgggtggg gtttgataat gatttgcagc tgcttctgat cagaaagccc 3255001 ctgcagcaca ccggaataaa agtcttctga aaagggctga gtggcaatga gcacaatttt 3255061 tttagtcggc tgaaaagcaa gttttcgata gaatatggac atatccatag gcgttctgtt 3255121 aaaaatctga tcgaagcggg gatgtcccgt tacgagaatc tgctcgggtt tacagccttt 3255181 tcgtatgaac cactctgctt catacgcacc aaaaacagct tgataggttg taaaaacagg 3255241 aatgaaggct tcatctccca tcaatgcgcc atgctgaaga caaatgctga cggccccttt 3255301 tctttgacac atgagagcga gcaccctgct gtaaatgtct tctgccgttc cgacaataac 3255361 agctgaaatc ttttcctgtt caaacagcgc atcaactgta tcaatggcct ctataaataa 3255421 aggaatatct ttgaaaagcc ggtcgcgaaa cgcttgatca ccaaatgccg ggtgatcatc 3255481 ataaggggcg agaagcgaac aggctgtttc gagatactgc ttcgaatcgc ctttttggca 3255541 tgaatccgca atctcccgct tgctaattac aggcagatca caataatgcg gcaaactcca 3255601 tctggccaaa acagccgttt tttcaggatc aaattgatag taattttcgt ttgaaaaacg 3255661 caggtaatca aagtgcaaaa tgactttccc tttaacaggt tcgtcatttg ttttaacgat 3255721 gttttggatt ctttcttcaa aaaacggctg aatctgtccc tcatcgatat gctgatccac 3255781 cgatccgaat aattccggtt cttcttccat catcaccctc agttcagggc tgatgtattg 3255841 ataaaaatta ctgataagcc caagcggaat ccctttgtag cgaagtttgt caaaaagctc 3255901 cacgtacttc cggtacagca cccaataatt gcttaaatag gccgacaagc tctcacccca 3255961 ttccaagctt ttttaatgat tcacgcagct ctcggcaatt tcgctgcgga ggaaggttcc 3256021 tgacaaattc atttttttct aattcaaaca gctgaaagtg aatcgattgg tcggtaatat 3256081 aattcaggtc cagctcctca tccagtgggt aaaacggata aaaatgattg actctccaaa 3256141 agaaccgggc atctcctata cggtaaaacg ccgggctttc atcccaatag gagccaaact 3256201 tctcctttac cttctcaagc accgaatacc tgtgcatcac cgagcaatga tcaattgcgc 3256261 acggcgcgtt ccatgtcact tgagcggcag gcctgacagt ttcttttaca atgtcacgat 3256321 tctcgtttaa atgataggtt ttggaggctg agtaaatcac agccttttca ggatgggtat 3256381 cgagctcccg caccattttc aggaggcggt ccggcatata gatgttgtca tccgtcgcat 3256441 aggtgatata ttcaccctcc gccatctcaa tcgcctgatt gatcagtgcc gcgtatctcg 3256501 ttttttctgt tctttccttc actccagata tatcgctttg ataaaaacgc actcggttat 3256561 cattcaaaaa aggacggatt acattcagcg tctcttcatt ggagttgtca tccataataa 3256621 acaattcaaa atctgaaaac gtttgtgaga gtatgctaga aatggacttt gccacataat 3256681 cgcttttgtt atagctcgtc ataatgactg atactttagg caaatcctac acctccttct 3256741 tggaacttca cacctgaaac tatcgttatc ttatgttgct tatgctcaag ttgcgctagg 3256801 gatacaaacc aatatgcgaa aagtttgtgt atgtttctga aaaacagcgg ctgcccagag 3256861 cgaaatctga tcggtccgct gttctttttc agcataatcc aagcatcagc ctcataaggt 3256921 gaaagagata aaaatcgcac cagcgactaa gatcgttttc catcggaggt gagtcatcgc 3256981 ggagcgttca cctatacatc cagaacatgt tttgaatggt tttcataaaa aggaggaacg 3257041 atatgaaacc gaaaaaaaat caatatcagc aaatgcaggc atttgataat atgcaggggt 3257101 atcagcctca gtttggcgcc aacccgtacc cgcagcaagg ccaaggctca caaatgcaga 3257161 caatggggat gcagccaatg atgccaatgc agcagggaca gcaaggacaa caaggacagc 3257221 agggatttgg attcccgggc cagcagcagg gcggcggttt tcaaattcca tcggggccta 3257281 caccgtcagg accgggccaa agcgttcccg gcatgctgcc tgttgaggaa tcttacatcg 3257341 agaatatttt gcgcctgaat cggggaaaaa cggccaccat ttatatgaca tttgaaaaca 3257401 gcaaggaatg gggctcgaag atttttcgcg gcgtcatcga agctgcgggc cgggatcaca 3257461 ttattatcag cgacccgaaa tcaggaacac gctacctgct cctgacaatc tacctcgatt 3257521 acattacatt tgatgaagaa attgcttata cgtatccata ttccatggcg tcctattcgc 3257581 caagataaga aaaaagccaa tcactcatat gatgaggatt ggcttttttg tttatagata 3257641 tttgacggct gcgacaacga tcataatcca agaaataata aacgccacac cgccgagcgg 3257701 ggtgatcgct ccaagaatgg agatttgcgt cacacttaga atatataagc ttccggaaaa 3257761 cagcacaatt cccgcaaaca tcagccagcc ggctgtcgtg acactgccta tgccggataa 3257821 tttatcagcc agaaacgcga caacgaataa cccaagggcg tgatacatat gatactgcac 3257881 gcctgtgtgc caaacctgaa gatacttatc aggtattttc ccttctaatc cgtgagcgcc 3257941 gaatgctccg agtcccacgg caagcagggc gttaatggcc cctaatatga taaaaacttt 3258001 catctatctc tcccgccttt tcgttaaact catatcattt atcttatcgc acctgcacca 3258061 aaattcaatg tttgttctcc gttgacacga gattgtcgga ttttctcctg cgccaaagct 3258121 ggaactggtc agctgctatt gcagcaagcg tccctaatac gagcccgttg cttaatagag 3258181 aaataaatac cggatgcaat ccctttaacg cagtttcagg aacaaacatg ataccgaccc 3258241 ctgtcagcag tgagataccg atgatagacc tcaccctttt tgattcttct ttctcatatg 3258301 aatcaaattc ggcaaaggcc agaccgccca ttgcggagaa cacaacaaaa ttcaccgcaa 3258361 atccaacggg tgacggcagg ctcgcaaacg tattcataaa aaacgggatc acgctgatca 3258421 cgataaccag aatactgccg agcataaacg gttttttaga aggcatcttg gtcgtttcaa 3258481 taaaacctgc ggctcccgaa atcggaacag gcgcaatagc tcccgtcaaa ccgctaagca 3258541 gatggctgaa tgaagctgca aaaccggcat ggcgttcatg atgctttcca tcaggctgtt 3258601 tgctgaattt tttcatggcg atgtccacga ccttcatgct cgccagcata ttcacgatca 3258661 gcaagatggt aataaaaata gaagtgatga tcaggccgct gttaaataac ggggtcccaa 3258721 aaggaaacag ggaaggcagc tgaaacagcc ggtccggcat ttcaatcggc tttgcggctc 3258781 cggcagccgc aaacagcacc cacccgccga acaaggctaa taaaatagaa tattgcttaa 3258841 aaaacatgat gttcgaattt gtcattataa aagcggcagc gatcacaaca agcgccaggc 3258901 caaatacaag accgtccacc ccgtcctgtc gataaccgat tccgagaatt ccttttataa 3258961 tgggctgact cagctgcatg acaagaagca ataaatagac gcccgttaca accggagtaa 3259021 acaattttgc aagtctgtca atgaccttga aaacacttaa caaaaagaaa catacagcgc 3259081 ttacaagaag agctccctgc aaaccccgca gtgtgtctcc atatgtcgca aacacagttc 3259141 ccgtcagccc tgcgtaaatc gtatacactc cccaccacaa gccggctggg ctttcattga 3259201 tcggcagtct gtggcctttc aaacactgaa tgacggcggc aattcccagt acaaaaaaag 3259261 tgctttgaat caatcttgca gaatctgagt gatccagatg aaacgactgg gcaaccgcca 3259321 ccggaacaac aatcgccgca gcaataataa acgctgtcca ttgcagcgcg ccaagaacca 3259381 atttcacgta agctcaacct ctctctttaa aaatcaaata aagactctcc gtttccatcc 3259441 tcttcctgct tctctttttc ttgctttcga tatttgttta atcccgcgct ccccatcatt 3259501 ttttccatca tcagctggtc tgtcgatggc ggcgcggcgg gacttggcgt aacgctcggc 3259561 tgtatgcggg gcgcgctcgc gttctccggc tgatcaagca cgacatcaca cagagaacgg 3259621 acaaccgcta cataacgctt cagctcctca tcccgttcag ccgtttttgc tttttttagc 3259681 tcttcttcca tcttttgaat caaagcagat atatgaatgt tcatgaagca ccctccaaaa 3259741 aaataaatgt tgtcttcctg cattttatca aattcctgct gaaaacgcag atatgagttt 3259801 gttatttttt ctgacaaacc ttgcgcgatt gacaagcaga agagattttt cacataataa 3259861 atcaccatac cttacaaaaa ggagaaacgg aatgaacagc atcccctcta tcatcagcaa 3259921 gcataaagcc tattttgcgg cgggacatac gagaccgctt gaatcgagac tgaacatttt 3259981 gcgaaagctg aaacaagccg tcagaactca tgaagccgat ctcatagccg ctctctacca 3260041 ggatctccat aaatccgagc aagaagcata ctcaacagaa atcggaatcg tcttggagga 3260101 aatcagcttt gtcatgaaac ggctgagaaa atggtccaag ccgaaacgag tcaaaacgcc 3260161 gttgactcat ctaggctcca aaagcatcat catccctgag ccgtatggaa ccgttttggt 3260221 gattgcgcct tggaactatc ccttgcagct ggcgctttct ccgttgattg gcgccattgc 3260281 ggcggggaac acggtcgttc tcaagccatc agaatatacg ccggctgttt ctgctattct 3260341 ttccaaactc atcagcagcg tttttccaac tgattatgtc gctatggcag aaggcgggcc 3260401 cgatgtcagc acagcattat tacagcagcc ctttgactac attttcttta ccggcagtgt 3260461 agctgtagga aaaatcgtca tggaggccgc cgccaaacaa ttaattcccg taaccttgga 3260521 gctcggcggc aaaagtccct gcatcgtcca taaagatgct gacattcagc ttgccgccaa 3260581 acgcatcgtc ttcgggaaat ttacaaatgc gggacaaacc tgcatcgcac cggattattt 3260641 atttgtccac gaggacatca aaacgaagct cacagaagaa atgaagcgtg cgatcagaga 3260701 attttacggc cctcagccgg aacggaatcc acagtacggc aaaatcgtca gtgagcgcca 3260761 ctatcagcgg ctgctcagct ttctgaatga tggcatcccg ctcacaggcg gacaatctga 3260821 tcccaatcat cacaaaattg cgccgaccat tctcgaacaa gtgagagatg actctccagt 3260881 gatgcaggag gagattttcg ggccgattct tccgctcttt acataccgca atatcgggga 3260941 agtcattgag aaagtccaat cgcgccctaa gccgctcgcc ctgtatctct tcaccacaaa 3261001 caaagaaatt gagcgcgctg ttttaggaaa tctgtcgttt ggcgggggct gtgtcaatga 3261061 tacgttaatg catgttgcga cgccgtattt gccattcggc ggcgtcgggg aaagcggcat 3261121 cggcagctat cacgggtttg acagttttaa cacattcacg cacaaaaaaa gcgtcgtcaa 3261181 acaaacgaac cgtttcgact tcgcatttcg ttatccttcc tccaaaaacg ggctgcgaat 3261241 gattcgaaaa atactcaaat aaaaaagcgc agatcacctg cgctttttac aaatccttaa 3261301 tacaccaatc aatcggcgcc tctcccattt tctccaaata ggcattcgcc cgggaaaacg 3261361 gtctgctccc gaaaaatccg tttctcgcag aaaacgggct gggatgcgtc gattcaatga 3261421 taaaatgctt ggaggtgtcg atccgttctt ttttcatttg agcatgccgt ccccacaaaa 3261481 taaagataac cggccgctct ctttcactca gcacgtcaat aattcggtcc gtcagtcgct 3261541 cccagccttt tcccttatgg gaattcgcct gtccgcgcct tactgtcagc acagtattca 3261601 gcaaaagaac gccttgcttt gcccagctca caagcgaccc gtgattcggg atgctgcacc 3261661 cgatgtcctg ctgcagctca agaaagatat tttttaacga aggcggctgc tttacaccgg 3261721 gcttgacaga gaagcttaaa ccttgagcct gtcccggccc gtgatacgga tcttgaccca 3261781 aaatgacgac cttgacatca tcatatgatg tataatgcag cgcgttgaaa atatcccggc 3261841 tgtccggata aatcgtttgc tccgcgtatt ccctcttcag catctctctg agctcttgat 3261901 aatacggttt ctcaaactct tcctttagct gattccacca gctgtcttgt aaaagctgtt 3261961 tcaagattca ggcctcctta cgaacgatga agtctggaat agacaggctc gccatcccaa 3262021 accatttcac tttttgcttc ccgcctcttc atctcaggct cttcaagcag gacggcaaag 3262081 tttttcgtcg gcagctcccc gagtccgtgc ttttcactta aacgatccaa atattgcttc 3262141 cgcttggcgc caaggtcagc agactgattg tctcccgcgt cactgaaggc ataaatcacg 3262201 ctggcgcaag ggacacgctt cacccggtaa tccttggccg cgcgcaaata aaaatcccag 3262261 tcccagtaat tgtgcacatc agcatcgaaa tacccgattt catcatgcag aaaacgtctg 3262321 tacatgctgc ccgacggcac gtatgtagaa aacactctca tatcctcata gtcagcggta 3262381 taagcaaaca atttccgtga cactggatac cttgttccgt ttttctcttc aaacgaaact 3262441 atttccgcat cagaatgaac gaagtctgcc gtttctattt cctttgccat tttctcgata 3262501 tgccctggcg taaagaaatc atcgtcatca cacagcataa tgcaatcccc agacgcctct 3262561 tttacaccgg catttctcgc agccacatgc cccgagttct tttctaaatt gatgacagca 3262621 atcggcagct ccggataaag tgctttgacc ggcacgaccg attccccggc atcattcaca 3262681 ataataattt catacggcat caaggtctgg cgggaaatcg actccaaaag ctcacacaaa 3262741 gccggaatcc gattataggt cacaattacg atagaaatct tcatgatgct ctccttctca 3262801 ttttcatagt catgtactat taaaacatat attggacggg agatcagtgg gaatatccta 3262861 ctgaaacggc atactacaat gatagaaaca gcaaagtggc tccgatcaga agcaccatga 3262921 tcagcatcag atctccaaag acatgaaaga tatctttcat gcggacgcca ttcggaagga 3262981 taagacgcca cagcttagat tgatagaccg gcagcagcac cagtgcataa gaaagacaca 3263041 aaaatgtaaa agccggcggc acaaaagcac agcctgcatc gtcccaattc atcatgatgt 3263101 ctttcatact agatccatcc aataaaaaca aagatatcat gagggctagc aacacaaagg 3263161 accccaattg aacctcaaac aggcgcattt tctggttata tgcaaatcgg accgcccaaa 3263221 accagacata agcatatgaa catagcagcg taagaatggc acctgctgta aagacgacat 3263281 caggcagccg atcaagcaga aaaacaaaag gcaagctggc tgccatagcc aagagcatgc 3263341 agccaccagt aaacaaaaat actgccccat gagctacaaa accatataaa caagagctaa 3263401 tcctcacgac atacacctcc tttacataga aattctatgt atatacctaa aaaatcagac 3263461 aagctgacgc ctgccaatat aacagcccat tcggccaaat aacggaaata acagcgttgc 3263521 aaaagcacaa gttccaacaa accaaggtgt caacaaggat tgaaacagcg cagcaggaat 3263581 tacattgaat agaaaaacaa gcataaaaat gacgtttggc accattgaga tcagaatcgt 3263641 atgtagaaca agcttttctc cgcgttttcc aaactccttc acgccttgat acccaatcag 3263701 cacccagtag atcatatatg cagctaagat cagccaaaca gaaacagaaa tgcctttcca 3263761 tactgcttga acaaacggtg attcaagcca tacatgcatt attgtaatcg caatgccgac 3263821 agcgaatagg gcactgttac agaaaagatg gaacatcaaa aacgcacgaa acgttactgg 3263881 ctgtattttc ttaaacgaag aaacaatgtc agttggtgtt ccaaacgcct gcaataaagt 3263941 ctgcatagct tcctcctcac tctttccttc ctgaaaagag cgaaacagat gatgttcaat 3264001 atggctctca atctcttcta tcatcgcctc accctcagga agccctttaa gcccgctttt 3264061 gatttcggat acatatgttt ctttatccat tttgtccgct ccacttcagt attcggtcca 3264121 tcatggctga aaatacgctc cattccttcg tgcgttccgc cagcacttct ttgccctcgt 3264181 ctgtaatccg gtaatatttg cggtccggtc ctttctcctg cttctcccag taggaagaaa 3264241 tatacccttg gcgttcaagc ttgtgaagag aaggatacaa ggtcccttct ttcatctgca 3264301 gttcatttcc gctgcggctt cccatttctt ttacaagctc atagccgtac atcggccgct 3264361 cgttcagaag cgtcaatacc aatataaccg tgcttccctt aaccagctca cgatttaaca 3264421 tctcaaaacc cctacctagt tttcttatgt agcattttac gaaagcccgt tgagattgtc 3264481 aaatgattcc tatagatctt ctatattgtg atacagagaa aatctaacta taatgaaaga 3264541 caaaacatga tggaggttca agacatgtct atgcataaag cactcaccat tgccggctca 3264601 gattccagcg gcggtgctgg gattcaagct gatttaaaaa catttcaaga aaaaaacgta 3264661 tacgggatga ccgccttaac ggtgatcgtt gcgatggacc caaacaacag ctggaaccat 3264721 caggtattcc cgatcgatac tgatacaatc cgcgcccagc ttgcaacaat tacggacggc 3264781 atcggcgtgg acgccatgaa aacaggaatg ctgccaaccg ttgacattat cgagcttgcg 3264841 gcaaaaacga tcaaagaaaa acaattaaaa aatgtggtaa ttgacccggt tatggtttgc 3264901 aaaggtgcta atgaagtcct ttatccggag cacgcccaag ccctgcgtga gcaattggct 3264961 ccgctagcca ctgtcattac gccaaacttg tttgaagcca gccagctcag cggcatggat 3265021 gaactaaaaa cagttgacga tatgatcgaa gccgcgaaaa aaattcacgc actcggcgct 3265081 caatatgtcg tcattacagg cggaggcaaa ctcaaacacg agaaagccgt tgatgttctc 3265141 tatgacggag aaacagcgga agtccttgaa agcgaaatga tcgatacgcc ttatacacat 3265201 ggcgcaggct gtacattctc agcagccgtg acagcggagc ttgccaaagg tgcggaagtc 3265261 aaagaagcca tttacgcagc gaaagaattc atcacagcgg ccattaaaga atccttcccg 3265321 ctaaaccagt atgttggtcc tacgaagcat tctgcactgc gcctgaatca acaatcataa 3265381 aaaaaggggc tgccttacag agaggcagcc ctttttaaat caccgaagac ttttcacaga 3265441 aaaaactgcc gatcccatcg gcagcctgtt tatttgattt ttaaattgtt tgcagatttc 3265501 ctcaaaaatg tttctatcga ctgaacaaaa agtgcatatt ccttcatttg ttcatatgcc 3265561 cgcgtgagaa tttccgccgt ttcactgtgc ggcgttgttc cgccaagcat ttttttcagc 3265621 tgaagcagca catccttata ttcttctcgc ttatcttcaa cttggttagc agccttttcc 3265681 aaacattccg gtgttatctt ctgttcatgt atattcaaga aaacaactcc ttttacagaa 3265741 aaaaatagta ggttatcgtt gaagaatagc acagatggct cagatttcac ataagaaaat 3265801 agaaggattt tctacataag tgtccaaatt ccgacattca tttcagattt cccggtcgca 3265861 ctggctgtta cttcatgatt tcccgggaaa ggaaaatatc ttgcactcaa gacctcttct 3265921 ccgttattga taaagatttc cacagatgac gcgtcgagaa acatgtgtac ggtatgcaaa 3265981 tccttgatgc ggcaatgtct cgcttctgtt ctttttccgt caaagctctt tcgttccagc 3266041 gtaacaatcc cctcgtcttt atggaaggaa aacgtagccg ttccgcggat actgattgaa 3266101 aagccagact ccgtatgaat gtcttccagt agaatctcag ttctttcagg tttttccact 3266161 ggaagcgcac cagatgatcc atgcatgttg atgtgtattt ttttctcatt tctgcgcatg 3266221 gcttttagct caggcagcgg ctgctgaatc agcttctgtc ctgaaagcgt cagctgtctc 3266281 ggcagcgtca tgcagtgaat ccagtggcag tcaatggtcg gatgggaccc ttcatcctga 3266341 tcaggcaccg ccatccatgc aaataaaatc cgccttccct gatcgtcttc aagtgtttgc 3266401 ggcgcgtaaa aatcaaaacc ttgatcaagc tccgtaaatt caccatgctt cagttcaggc 3266461 ttgttataat cgaggcggcc gacaaaataa cctgattgat atacgttctg ataacggaaa 3266521 ccgtcagcct caagcccttg aggcgaaaca atcagcacat ccgatccttg aagggaaaac 3266581 aaatcagggc attcccacat gtatccaaaa tcgtccagcc cgttgaagcc cgcgccggtt 3266641 atcgggccaa gaaatctcca ctctgtcagg ttatcagaag caaacaacac agcctgccct 3266701 ttcaaattct ctgtttgcgc accaatcacc atataccatg tgccttcatg ctcccatacc 3266761 ttcggatcgc gaaaatgcgc cgtatatcct tccggaaggc gggcgacgac accctttttc 3266821 tcaaaggaca gcccgtcgtc agaaacagca aggcattgat acgtttcccg atttccatcc 3266881 tgatccctga catttcctgt gtaaaaaaga tagagccgat cgtctttcgt gacagcgctg 3266941 cccgagtagc agccgttttt atcaaaccaa tcactcggag ccagcgcaat ctcttcccgc 3267001 ttccaattca caacatcctg tgtcgtataa tgcccccaaa attttgcgcc gtgccccgtc 3267061 tgaaacggct gccactgaaa gaatacatga tagctgccct tccaataaat cacgccattc 3267121 gggtcattca gcagcccaac cggcggcatg atatgaaaat gctggcggtg cggatcgctg 3267181 ttagcgatgg gctctttttt ctccacttct tcataagccc ggcgacgaag ctcctggtca 3267241 tgtgctgtca ttttttcctc tcctcatcct cattaatctt catgacaaat gctgcaatga 3267301 acgctgacac tgccgcaatc gccatgccaa tcagatagtg aatcaagttg ctgaagccaa 3267361 acggagccgc aatggcgatc atcggaattc ccgttaaccc gtaagcgttt gcagctacat 3267421 gtgtaaagac gacatatgcc ccacccaatg cgcctccgat catcgcggcg ataaacggtt 3267481 ttcggtagcg cagattgact ccgaatatga cgggctcagt aatgccgaga aaagcggaaa 3267541 atgctgccgg aagcgcgatt tcttttgtct ttgccttttt cgccataaag aagacggcaa 3267601 gacctgcccc gccctgtgcg acattcgcca ttgaccagat cggcagcaag tagtttttgc 3267661 ctatatctgc aattagccct gcctcaatcg catggaagct gtgatgaacg cctgtcagca 3267721 cgatgagtga atacgtgccc ccgaaaatca gacctgcgac aaaaccggca tggtcatata 3267781 cataagttaa agcaaccgta atgccggagc caagcgctct gcctagaggg ccaatcgcga 3267841 taaaagcaac aaacccggtg acaatcacag taacaaatgg tgtaacaagc aaatccaccg 3267901 catgtggaac cacttttctc gtccatttct ctaccttgct catcacatac accgcaagca 3267961 ggacagggat aacagttccc tggtagccga gaagagcgat atcaaatccg aaaagatgca 3268021 tgtaatcagg tgtcgcttcc gccaatcccc atggatttaa aagattcgga tgaatcatga 3268081 ttcccccgat gaccgctccc aagtatggat tgctgccaaa ctcttttgaa gcgctgaccc 3268141 cgattagaat cggcaagaaa atgaatgctg cacttgaaaa catatcaagc agctgcaaaa 3268201 gcgcagaatc cttgctcatc caatgaaacg cattgatcat acccagcaat cccattaata 3268261 ggccgctggc tacaatagct gggatgattg gaacaaaaat attagaaagc gttttcgcaa 3268321 atctcgcagc gggattcagc ttttcttttg ccgcatcctg atgattgacg tgttcttcac 3268381 gctcgatatc agcttcttta gaaaaggcat cgaatacttt attcacaagg cctgttccga 3268441 aaatgatctg gtactggcca gagctgctga aagccccttt aacgccatca agctcttcta 3268501 cttgtgcttg atctatcttt gattcatctt tcatcactaa acgcagtctt gttgcacaat 3268561 gagccgcgct gataatattt tctttccctc cgagaagctc aatgaggcgt tttgcagtct 3268621 ctttgtaatc catctatttc tccccctttt atttaaacaa aaaagaccta aaattcgcca 3268681 acgaataaag gacacagcga tcctttttca tttacgcaaa ttttaggtct tgcctgcttt 3268741 accagtcaca atcccgctta ttcagattaa gaatacgctt tcatcataaa tcatgatagc 3268801 gttttcgtca actatttttt tagttaaata gtttgatata acatgtagac aaaaattcgt 3268861 aaaaattaat tgtgaaatac ttcacaatat cgtgctatac tatgctcaat catgaaagaa 3268921 agcaggaaaa gacaatggaa actcaagcat tacaaaaggt tgaacagtat gctttgaaaa 3268981 aacaaaacat attcgcttca agcaaaatcc gttatgtgct tcggtccatt ttggccagta 3269041 tatttattgg ttttggcatt acagccgcaa gcaaaacagg cagctatttc tttatggctg 3269101 attctccgtt tgcctttccg gcagccgctg tcactttcgg ggccgctatt ctgatgattg 3269161 cttacggagg cggagattta tttaccggca acacctttta tttcacctat accgcgctcc 3269221 ggaaaaaaat cagctggcgc gacaccctat acttgtggat gtcaagctat gccggcaatt 3269281 taatcggcgc cattctgttt gccatcctga tcagcgcgac gggacttttt gaggagcctt 3269341 ctgttcattc ctttttgatt catttggcag agcacaaaat ggagccgccg gcttccgaat 3269401 tgtttttcag aggaatgctg tgcaattggc ttgtgtgcct cgcctttttc attccaatgt 3269461 ctctcaaagg ggaaggagca aagcttttta ccatgatgct tttcgttttc tgcttcttta 3269521 tttccggctt tgaacacagc attgccaata tgtgcacatt cgccatctcg cttttgatcg 3269581 agcaccctga tacagtgaca ctgatgggag cagtcagaaa cttaatcccc gttacgctcg 3269641 gcaatctgac cgcgggaata gttatgatgg gctggatgta ctacacactg aatcctgatc 3269701 aataaaaaaa cttccagaga tcactccctg caagtcaaag cggttattcc gagagatctt 3269761 gaagacgctg gacatgcagc gtgatatagc cggcctcgga ttccggcaaa tgtaattgat 3269821 attcattttt caaaaactcc gccagctcca gcgcacattg ataggcgaat gaatactttt 3269881 tttggatgaa ataaagcatc tcctcgtcca tacgatggag cgcttcattt gattccaacc 3269941 ggctgaccgc gtatcgcaaa tgcgtgacaa ggcgttgata ggaaatgctg ttttcatcca 3270001 cctttcgatt aaagtattgt tttattttct ctatcatttc tttgatcatg gtcgtatgct 3270061 tcagcgctga atacatgctc tccgcatcca tcttcgccgt atggatgtga agggcaatat 3270121 aacccgcttc atcttcaggc agagacacgc ccaatgtctc ttttacatgt ccgatcgccc 3270181 acaggccgat ctcatattct tttttataga gcgcctttat ctcatgcagc aatttattct 3270241 gcacaagcag cccattttga atcctttcga tcgcaaagga caaatggtcg gaaagcgcga 3270301 tatgaatgtg atcgctcagc ggcgccgcga gctctccttc cgcatagctg atgatatcct 3270361 cagctatttc tatatgctcc tccggcagtg tttgcaggat ttgtttgaac ttttcattct 3270421 cgtcgcgcac gacaaagatc ttttccactt tattcatagg gatgagatca tttttctttt 3270481 tttgaaaagc gattcccggt cccatcacga ttttttcctg atcatcctct tttattaaag 3270541 ccgcattgtt gtttaatact ttatagattt tcaagaggtt atctctcccg ccaatttgct 3270601 tttgactggg attttacctc cttttgaccg ccatgtaaag atgcgggccc gctctctcct 3270661 gctttggcga ttccttgaag gcttgcaaac atcttctttt ataaagcgcg gcggctttcg 3270721 ctttctgctt ttcttcctca ttcacagcca tccgccattc ataaaacgaa acgagtcctg 3270781 cggcctgcac agccgccttt ctttggtatg tacgctgagc cgaatagacc gcggcagccg 3270841 cagtttttct gtccggcgtc acccagttca tcaaaaagac catccacacc cgtaaagata 3270901 caagcaaacg tttcatagaa aaacatccct ccgcttcttt ttggcaggca gcctttttag 3270961 cagcccgttt tctcagccgc agcccgcaag aaaagacggc cgatttcttt tctcgcaaac 3271021 tagcggctct agcaaaactc atgactctat gatagaccgt ggaaagagaa ttctttgtca 3271081 caatatgagt gaaaaaacca actagttttt agaagttttg ttgaaagctg aaagaattga 3271141 aatgaaaatt ggagaaccgc tttgaaaact ttatacacaa gttatcccaa agataagaac 3271201 aacttaatca caagagatat ccacatgtcc acaaactcta tctatatttt gtatacgaac 3271261 gtatattcct aactatatat atacacaggt ttattcactt atacacaggg ttctgtgtat 3271321 aactccttcg ttatacacaa acaaaatcca ataaatggtc caaatgacac aaggattttt 3271381 ttgaattttc aagaaatata tactagatct ttcacatttt ttctaaatac aaagggggaa 3271441 acacattgaa aaaggggatc agtcagcaaa cgcctcctgc aataagcgat acgatcggag 3271501 cttatcttca aaatgatgcg tgatggtcac caccatgatt tcctctgttt catacgcgtt 3271561 actcaaagct aacagccgct ccttaacctg ttctttcgta ccaacaatca ttcgatttcg 3271621 attatcagca attcgtctct gttcataagg agaatacgta tttttccgaa cagcttcata 3271681 cgaaggaact ccctctaaag gaataccctg ctctcccgcc aaaagtgtaa aatcaagcac 3271741 agccccaagc tcctctgcct tctcctccgt gtcagcacaa agaacaaaaa cagcaactgc 3271801 cgctcgaggc gtatctccta acacagacgg tttgaatcgc ctcttatact gtctgacagt 3271861 accctctccg ccctctccat tgataaaatg ggcaaacata tagccagcgc cagattcagc 3271921 tgcgagcagc gcgctttctc cagatgagcc gagcagccac acatccggag ccgttgaaat 3271981 atgcggcgca gcggtcagat tcggaaaacg gtgtttgtca tccgccaaat catgcaaata 3272041 catggtcagc tccttaattt gctgcggata ctgatcagca ttgcgcttac caccgtcatt 3272101 cagcgcccat gatgcaatcg gcattccccc cggtgctctg ccaagcccca ggtcaattct 3272161 tcctggtgtc agcccctcca gaacacgaaa gttttcagct actttataag cactgtaatg 3272221 cggcagcatg actcctcctg atccaacacg aattcgcttt gttttcgctg ctatatgact 3272281 gattagcacc tcaggactgg accctgccag ccgttttgaa aagtgatgct cagaaaccca 3272341 aaatctctta tatccaaggt cctcagcagc ttgggcaagc gcaacggttt gctgtaaggc 3272401 cgtttctgca ttgctgccct ctgatactgg agattgatct aatatactta atgaaaccat 3272461 ccctaccacc tcatcctcat cgtatcactg atcccctatt ttttctccaa agccgctcac 3272521 actgcttatc agtgtcccct atcattcgcc atttatttgt gaaagcatgt ccctatttgt 3272581 cggaatatgt tacacgtgaa acataaaaac ccctccagac ggagaggttt gctttagttt 3272641 ttattaaagc ccttttcttt cacgtagtca tttaaatacg tacgcggctt ttgcttcata 3272701 aagttcagta tttgatcgga ccacgtttct tcccgcttcc cgtttgttct ttctctatag 3272761 taatcagaaa tggttttgtc atacgtattc atagtatgac ggaaatcgtc tgtgttcaca 3272821 ttatacgtat tttcatgata aacggcctgc tttggcaatc tcggtttttt gccggaaagg 3272881 ttcgcaggat ggcctactgc cagtccgaaa agcgggagca catggtcagg cgtttgcagc 3272941 acctctgtca ccttgtccaa ttcattccga atgccgccga tatagcaaat gccaagcccc 3273001 atggattcag cggcaatgct catattttgc gctgccagcg ccgcatcaat caagctaacc 3273061 ataaacattt ctgtattctc gagcagctca gaaatatgtt cacctttttc ctcagccagt 3273121 tgttgatggc ggtacaaatc cgcacaaaat acaaaaaagt gtccgttctt ctcaacgtaa 3273181 ggctgattcc cagcaagcac ggacagctca cgttttttct caggatcaga aaccccgata 3273241 atcgaatatg cctgcacata gctggatgta gacgcagcct gcgcactttt cactaatgta 3273301 tcaatttctt cagctgtcaa aagctgatca gtaaaagacc ggattgaccg atgattcaaa 3273361 atggtttcga ttgtgttatt catcacaaaa acctccttat cactttttat catatccgaa 3273421 aaaaagtgat ctcaaaagtg aaatgctctg cacaaaaaaa gacagcctct gtaaaggctg 3273481 tctgcatatc aagaattaaa aagataactt ctgtatttcg tcagctgcac acttgcatta 3273541 tatacaatcc caaatccgat taacgtggaa agtgtcgagc ttcccccata gctgacaaac 3273601 agcagcggaa tcccggtaac aggcataatg ccaatgttca ttccgatatt ctggaatgtg 3273661 tggatcacaa ttaacgccgt atagccaacg caaaagaaag aagcgaaacg gttaaacgga 3273721 tgtattttgt ctatcagaac aacaagcctg tagattaaaa agaagaacat gatgacaaca 3273781 attgcacagc ctataaagcc aaatgactca cctattatag aaaagataaa gtcagtcgta 3273841 ctctctggaa cataaacctt caaattagaa ataccattac ctaaaatacc accagatcct 3273901 attgccatga tggcctggtc aacttgccag ctgtcatttg aatcttcctg tgtctcattt 3273961 gaagcagaca cccaagaagt gacccgctta atttgataat cctgtattcc aactgattta 3274021 gcaacgtcag gaaagtttat cattactaat aaaattaatg aaatgagtaa gatacctgaa 3274081 ccagctatga tcgcaatcaa tttccaattt atccctgaca taaaaaccat tacaagaacg 3274141 ataaacatac atattcccgc agtcccagca tcctgcatca ggataagacc tacaggaata 3274201 actgcgacac ccgcaatctt taataacaag tggatatcat ccctaagcgt ccgaactcct 3274261 ttaggatttg cttttccaat aactgaagca agcatcataa tcaaaccaac cttcataaac 3274321 tctgacggct gtattgttat tctaccgatc ctaaaccaac tttttgcccc tttaataaca 3274381 ggtgcaatag actcgggact gattttaaga ataatcaaag ataaaatacc aatgataaaa 3274441 atatataaac ttaacttttc aagctgttct aaatcaaagt acaaaagaac tgtaatggct 3274501 acagccccca aaagataaaa cacaatttgc tgaatccaat ccgtgttccc atactgccca 3274561 aactgaccgg cagcatatat tgatactacg cttataataa aaaacacacc aaatataaaa 3274621 atcaaatccc cctggtaaaa ggggctttgc tgtttcttat atcgactcat tctatcccgc 3274681 cttacatttt catcggaaaa tcactaatgt ttattataca tgaaccacgt tcaagatgac 3274741 acgtgaagct cgcttccttt tatgtttttt cagcatttgc ggcgcttttt cagctacacg 3274801 aaatatgacg tatcataaac cgaaatgttt cgattgacac aaaacttttc aaatgaaaaa 3274861 aacgccatac caatagaatt tgttaaaaaa cgaatgcgat aatgtgttat gttcccaaat 3274921 aatgtgatac ctcatataga aatagctaaa aattcagagc cccatgccca tacattctcc 3274981 tagcacatta aacgaaaaaa taagacgata gatccagtcc atttctgcaa aaacacgtat 3275041 caatttctgg aaaacatggt ataataattg taacagaatg ttcaaaaaac aatcacaaaa 3275101 cagacacaac tcagttcctc tatttcattt ttgtaaacgt tatcacaaaa tgaaaggaga 3275161 cgggtatgat ggacatgttt tttgcttact tattggttgc cagcgcaacg cctctcttta 3275221 tttggcttga taacaaaaaa gtcgcactct cagctattcc gccaatcatt ttaatgtggg 3275281 tattcttctt cttttacgca acagaaagcc tttctccact tggacacact ctcatgatta 3275341 tcttgtttgc cgttaacgtc attgtcgctc atatcgccgc atttatcatt tacggccttc 3275401 cgtatcttcg cagaaagcga agcagctgaa gacagcaaaa aaccctcttc cactgaagag 3275461 ggttttttgt attattcgtt atggcctgaa tgctctgagt gttcagcgcc tccaggagga 3275521 tttccgtcca tatggtcacc atggtgatag tgagccgcga aaatccagat ggatccaagt 3275581 acgataacga tcgcgccaaa gaatccgaac agcgtgtttc cgacttggat cgtgccgttt 3275641 tcgctctctg tcatatgcat gaacatgaga agctgcagcg ccgcctgaat gaaggcgaag 3275701 ccgaagataa tccaaagttt tgctgatgag ctcaggtcag tatacactgc aacccataga 3275761 gccagcaggg tcaaaacgat agacaggata aaacctacaa tgtgtttcca tggaaagtga 3275821 ctgtgttcag cagatttgtt tgccatttta cagacccccc aatcccatga gatagacacc 3275881 tgtaaagatg aaaatccata caacatctaa gaagtgccag tacaagcttg agataaagat 3275941 tttagatgaa gtttgcggag ttaagccgcg tttcttcaac tgaatcagaa ttcctgtgat 3276001 ccagaaaatc ccgattgtta cgtgagttcc gtgagttcca agtaaaacaa agaatccaga 3276061 ccagaacgca cttgtactga gagccgctcc ttcatgtaca tagtgaacaa actcgttgat 3276121 ctcgcatccg acgaagccgg caccgagaag aagagtgata attgtccaaa tgactacgcc 3276181 ttttaaactt ccgcggcgca tttcatgaac agcgatcccg caggtaaagc tgctgatcag 3276241 cagcaagaac gtcataatca ttaccagatt gacttcaaat agttcgtctg gcaagacacc 3276301 tccagctgtt ctgtttttaa gaacgaagaa ggttgcaaat agtgttgaga acaacacaat 3276361 ttctgcccct aaaaagatcc aaaacccgag aatattaagt ctgccggttt cagattgata 3276421 ttccataggc gcgttagaat tgccgtgttc tgcatgttcc ataactcacg cctccttatt 3276481 cggaaatctt tctttccgtc tcttttattt catcaacact aatgtagtag ccgttgtcgt 3276541 attcgaatga acgcagaacc atgcagagca ggactccgat caatccgact acgcccatcc 3276601 agtaccattc aaagacaagt ccaaagcctg cgagaccgaa ggcaacagac ataaagaacg 3276661 gtctgcctga gttgcttggc atatggattt tcttgaattt gctttcaggg tataattcag 3276721 ttttttcttc tttcatatgc aggaatgcat cttgagattt gacttcagga agcaccgcaa 3276781 agttgtaatg cggcggaatc gcagaagaag tcgcccaatc aagcgtacgt cccacacccc 3276841 atgaatctcc gctgatttca cgagtagagt aacggaagct gtagtagatg ttatagcaaa 3276901 ggattaagaa tcctacaccc atcatgaaag ctccgactgt tgagataaag ttcaatgttg 3276961 tccagccgtc attcggtccg tatgtgtaaa tacggcgcgg catgccttga agccccaaga 3277021 aatattgcgg gaagaaacaa atattgaacc cgatcataaa gatccagaag aaccattttc 3277081 cgattctttc gttcagcttg tggccgaaca tttttggata ccagaaaata aatccggcga 3277141 aacaagcaaa tacagtaccc gcaatcagca catagtggaa gtgagataca aggaagtacg 3277201 tattatggta ttgataatcc gctgctgcca tcgcaagcat aacccctgta accccgccga 3277261 taacgaagtt aggaatgaac gcaagcgccc acagcatagg tgttgtaaag ctgattcggc 3277321 ctttatacat tgtaaagagc cagttaaaga ttttaacccc ggttgggatt gagattgcca 3277381 ttgtcgtaat tgagaagaat gagttaacgg acgcactgtt ccccattgtg aagaagtggt 3277441 gagtccaaac taagaaactc aatacagaga tggcgataat agaaccaacc atcgctttgt 3277501 aaccaaacaa ttgttttctt gcaaagcttg agatgatttc tgagaaaata ccaaacgccg 3277561 gaagaataac gatatatact tcaggatgtc cccaaatcca gaacaagtta gcccaaagca 3277621 tcggcatacc gcctgcttcc aatgtgaaaa agtgagcgcc gaacaaacga tcaaatgata 3277681 aaagtgctaa tgctactgta agtacaggga acgcaaacac gataataacc attgtgatca 3277741 gtgttgtcca tgtgaacatc ggcatacgca ttaatgtcat gccttttgtt ctcattttta 3277801 agattgttac cataaagttg atccctgtca tcagggtacc gataccggca atctgaagtc 3277861 cgaggaggta gtagttctca cccggcccag ggctcatgtc gttacttgca agcggcatat 3277921 aactcgtcca gcctgcgttc ggagaacctc cgataacgaa agaaatattg aaaagcatcg 3277981 cccctacaaa gaacgtccag aagctcaggt tgttcaagta agggaacgca acgtcgcggg 3278041 caccgatttg aagaggcaca acaacgttga taagaccgat taagaacggc atcgccatga 3278101 agatgatcat gattgtaccg tgagttgtaa aaatttcatt atagtggttt gagtctaaaa 3278161 aactgttatt cggaagcgct agctgggcac gcatcatcag accgtcgaca ccgccacgga 3278221 ataacataat tacagcagat ataatataca tgattccgag ttttttatgg tcaacagtag 3278281 ttatccattc agaccacagc catttccact ttttgaagta agtcagaaca aaaataatgg 3278341 caatggttga aagcgcaatg gaaacttgtg cgcccagaat taatgggtca ccagttacga 3278401 aaaattcgtc ccatttgaat ttcatgcagg cttcctcctt tcctgatcaa tatcattctt 3278461 ctgtatcatc agacttctta aattcgtttt tctttacgtt ttcaaacgga tctgttttag 3278521 aatgcggtga aacggcttga tagccaaggc gtttgcgcgc ctccatcgcg tactcagcgt 3278581 cttgtccgtg atcaacgtat ttcaagtgag tagaagagaa cgttaattcg tccacatttt 3278641 caggaagcat caattcatca tacttctctt ttgtcagctt aggagcctcg ttctgagtct 3278701 ttttcaccca gctgttaaag tctttttctg tgactgcatt cacatcaaac tcttggtctg 3278761 caaaatgttc acctgtgaag ttcgcgttgc ggccttcgta agtacccact ttgtcagcct 3278821 gtaagtattg atccatcagc attcctgcca tcgcatattt ttgccctcca agctgaggaa 3278881 tccatagcga agccattgaa tctgcagatg agattttgaa caagatcggg cggtcgacag 3278941 gaatgtttaa gtagttgacc gtttcaatat cctgttcagg gtagctaaat acccatttcc 3279001 agtctaccga agtagcataa acaacaagag gctctttgtc ttttgttgct tcaggagctt 3279061 tttctaacga atatatcgtc tgtactgttg gcacagaaag tgcaatgacg attaaaattg 3279121 ggatcactgt ccagactact tctaaaaacg tgttaccgtg aatttctggg ttataagatc 3279181 cattatcttt gcctttacgg tcgcggtatt ttactaaaat aatggtaaat agaacaaaga 3279241 cgaccccgac gataaacagc ataaatccga tagataacag gattaaatca ctttgctgtt 3279301 cagctacagg tcctttcgga tctagtactg aagcattgct gcatccccca aggacgaaaa 3279361 ccacagttaa cagcgctaat acaagcaacg gttttaatgc tctgaacaag aagatcacca 3279421 tccttcctat tgatgtaata aatctgaagt gcatacttcc tcaaaatctt ttctctactt 3279481 tgttatgcta tcaaaaactt cacttattag ctttattttt ttataaactt catcccattt 3279541 tcgcttaaat gtcataaaat cgacaaaaat tgctccaact ttattcacat ctatcgctta 3279601 agatgaaaag tttctagtta tttccgcata taaagtaaag aaagatgatg aagaactaat 3279661 tctgacaaat taaggtttac cacaataaaa aacttaggtc aatcaaaaat ttcattttgt 3279721 taaactttct agataggaat tattttttcc tcgtctagca tcttttcaca cggttaccat 3279781 tttaacgcat caaatattga aagaaaaggc gcaatgaaga gccaatatgc tctgaattgt 3279841 ccgtattttt ttatgagagc atccagttgt ttatcttata caaaaaagag gaatgatata 3279901 agcaaataaa taaaaaatag gatgtgttgc atgatgagtt ttcttatttc acttatcgtc 3279961 gctattatta tcggatggct tggaagcctg tttgtaaaag gagatatgcc cggaggaatt 3280021 atcgggtcta tgatcgcagg tcttataggc gcctggatcg gacacgggct gcttggaaca 3280081 tgggggccgc acctagccgg atttgccatt attccagcgg taatcggcgc agccattgtt 3280141 gtctttctag taagcctgtt aaccagaaaa agaggataaa agcagcagca cccgaagcgt 3280201 cagcgctttg ggtgtttgtt ttgccataaa aatcgaaaaa gcctcaaccc tagcggttga 3280261 ggcttttgac tggtttggcg cccaactgat cgatgaacct tctgaaggcc tgttttccct 3280321 ctgctgtctg cttaaataca ccggcgtgtt caaggatgcg cgcgaataca tgtcccagct 3280381 cttcttttat gactagatct acgttctctt ttgttatggt tcttttttcc atcgtccgaa 3280441 gagcccactc actatgcttt gcagtgagcg gattttgttc taaggctgtt ttcggatcag 3280501 cagaacatag cgccgctgcc gtttctttca tttcctcctg taagcggcca ggcaatatcg 3280561 ccaatcccat gacctcaatc aggccgatat tttctttttt aatatggtgg acttcttgat 3280621 gaggatgaaa tattcctaat ggatgctcct catccgtccg gttgttcctc agtacgatat 3280681 cgagttcgta caagtctccc ctgcgccgcg caatcggtgt gaccgtatta tggggcgtat 3280741 cgcctgtata ggcggcaatg ccggcttttt catcggaata cgtctgccac gtgcggaaga 3280801 tatggtcagc agcttcggcg acatgacccg gttcgtctcc ttggagcctg agcacagaca 3280861 tcggccactt cactaagccc agcgacacgc cgggataatc atttaattca taaacgtctt 3280921 ccgcttctgc acgtgccatt ggaaaatcat gcgcgccgcc ttggaaatga tcatggctta 3280981 ggatgctgcc gccgacaatc ggcagatccg cgtttgaacc gataaaataa tgcggatatt 3281041 ggccaagaaa tgacagcagc ctttcaaatg tttttttgct gatctccatc ggttcatgtt 3281101 caccttttaa gacaatgcag tgctccggat aatagacata tggcgagaat tgcaggaacc 3281161 attgttcgtc ctcaaggatg accggaatga ttctgtgatt ttgccgggct ggatgattca 3281221 cgcttccctc gaagccgaca ttttctttac acagcaaaca catcggataa tttgtctgtt 3281281 cctgctcttt tgcagccgca atcgctttcg ggtccttttc aggctttgat aggttaatgg 3281341 tcatttccag ctcgccatat tcggtcggca ccgtccaatg aacatttttg gcgattctgt 3281401 cagtccgtat ataatagaca tcctctgaat attgatagaa ttcctttgtc gcctgttttg 3281461 ggccgtataa tgcttttgtc tcttcaaatt tgcgaatgac ctcggacggg gcaggcacaa 3281521 aacagcccat cagctttgcg ctgagcaggt cacggtacgt atctgtatcc gcttccattc 3281581 ggccggtttc ggcagcccat ttatagatgg gagctagcaa gtccggcagg ctttgtgact 3281641 gcttgatgct ggtgctggag ttcggctcgg gatgtgtgat gcccagcgct tcataaagac 3281701 ggtttctcgt atattcccga tcccagatcg aaatcaattt tcgttccagg ccatactcaa 3281761 gcagctgttc cagatgttca ataatactca tatgtcactc cccctttagt tctctcgctc 3281821 cctctccgat atccgcgaca taaaagtccg ctcggagccc tgttttttct tgatatctgt 3281881 ctccaacctt ctgaataaaa tcatcaacga actcatcttt tacaatgctg atggtgcagc 3281941 cgccaaagcc tgctcccgtc attcttgatc caattacacc ttcgtgatcc catgccgcaa 3282001 acacaagctc atcaagttca gggcatgtta cttcatagtc atccttcaat gaaaggtggg 3282061 attccttcat taactgcccg atttcatcta tattgttctc tttgaacata tgggccgtct 3282121 taatagcacg atgattttcg tatacagcgt gctttgcccg gcgtctgttc gtttcatttt 3282181 ggatcaggct ggaatgcgca tcgaaatcag aaggcttgat gtcgcccagt gcggcaatat 3282241 cgaggccttt tttcagatca agcaatgcat cattgcattc ttggcgtctc gtattatagc 3282301 tggagtcagc caatgtcctt tttttgttcg tgttcgcgat gaccagcgcg aggcctgaga 3282361 cattgagttt gctatattca tagtcaagcg tgtcacagtt cagcagcatc gcatgatgtt 3282421 ttttccccat tccaattgca aattggtcca taattccgca attgacgccg ataaaatggt 3282481 tttccgcatg ctgcgccatt ttcacaagct caagcgcatc tacttcagga tgaaaataac 3282541 tttggagcac gacccccatc agcagttcaa tagaagcgga agacgacagt cccgccccgt 3282601 ttggaatatt ccctgaaaat acaatgtcaa agccatgggg aactgcatat cccctctgtt 3282661 gaaattcata aatcacgcct tttgggtagt tcgcccagtc gtcttctttt tgatagcgaa 3282721 tgtcgtcaag gctgcattcc ttgatgcctg cgtttctaaa gttatctgaa tacatccgga 3282781 caagcccgtc gtttctttct gcaacagcag catatgtacc cattgtcagc gcgcacggaa 3282841 agacatgccc gccgttatag tctgtatgtt ctccaatcag attcactctt ccaggtgcga 3282901 aaaaaaaccg taacccctct ttttctccga atacacttgc aaatatcccc tttagctctt 3282961 cccgcatgtg caatcacctt tctggttttt attttttatt ccccttattt cttcatagaa 3283021 aacggcagat catatgctgc agtcctctca taccccttct tcttttgttt ttttaaagac 3283081 gagccatttg ctcgcaacat agttgacgac aacaatgacc gcgttgtcga gtattttggc 3283141 caaggtttca tttgtattga actggccgac aagaatgatc atcatgccta aatctatgcc 3283201 gagagacagg acccgaacgc tgaaaaaagc agtgagctct ttcagcaggc tctgcagatc 3283261 atgtgttttt tgctgaaaca catataattt atttgttatg taagcaaaca gcacggacaa 3283321 aatccaagcg gcaacagtgg cggctttgta atccacattc atgatctcta ccaatatata 3283381 aaagctggcg atattcacaa tggttgtgaa aacccccata atgatataca taattatttc 3283441 tctatacttc actgatgttc ctcgctttct gaaaaacttt tcaaaattct tggcctctcg 3283501 tgctctctgt ctaaagtaaa aaataccgag agtgcgtcta aaaagctgcg gaaggtggct 3283561 ggctggccca atacatatga ttgtttgatg attccgtcga ggactgcaca tattatttta 3283621 gccgtatatt caggatcaat acaggcgtca atcagctttc tctccttcag ccacttaata 3283681 tataacacat tttcttccac ccacaattcg tacagccgga cataggcctt gcatttcttt 3283741 aagactttat atgtcggcat gttcatggca aacgaggtga tgtcccacga cggcttattt 3283801 atgtaatagg aataaagcag ttctgcagcg tgttttgcag cctcgtccaa tgtcagcgat 3283861 ttcactgact cccgctccat ttgatcaaga taccctataa tgatcttttt tttcatctga 3283921 cgtttttcga gaaggtacag cagaaaatcg tccttgctga caaaatgaac ataaaatgct 3283981 cctttgctgt acccggcggc tctgctgata tcttctacag aaaccggatc atacgctcgg 3284041 tcaatcaaca aattcacgcc agcgtctata aaactttcaa atgttgcttc tcttttaatt 3284101 tgaaatttgt tttttttcat atttttctcc tggcggtaat gattaccctt atcttacacc 3284161 ggatcaatct ttagcggtat ttatttcttt aaacggttat gctattcggt ttcccagggg 3284221 tcatttttaa taggctaaat gatttatttt catttacata ctatccagtc agtatttaat 3284281 tgtttattat tataaataag gtccattggt tatattagtc atttttttag ggaataggta 3284341 ggtggttttt ccttcagttt gtgaacaccg agcaactatg tgtgaaattt gttgtactcg 3284401 cctccatcat cgcgctggct tgtcttttat tgcccgcatg ttgcaggaaa acattttata 3284461 caattggagg ttactatgaa aactcatgtt aaaaaagatt tggacaaagg ttggcatatg 3284521 ttaattcaag aagctagatc cattggatta ggcattcatg atgtgaggca gtttttagaa 3284581 tctgagacag catcaagaaa gaaaaaccac aaaaaaaccg tccggcaaga ctagtccgaa 3284641 caggcggatc tatttacctc tggcttttct atcacctgat ctgagttttc accatatcct 3284701 ctattcaaaa gcaaatcgct gcgctgagct tgaggacaaa cggtgtgtca gctaactacg 3284761 acagacagcc ggtgatgcga tcacctcttg gcacatgcat tgtcataaag aggtgatgcg 3284821 aacatgataa ccgtgctctg gtaaacagca gctttgctga gaacaagctg cattcggtga 3284881 ggttttgaaa gcaaactcgt ttatacacgg ccgagcttga aaaccttcgc ctgtctttag 3284941 accactgtgt tcacctcttc acgacttcct tcttttttca tcctccagct attgtacaac 3285001 gcataaatcg gactttcagt acatacctat tggtgtacct ttttgcttac gtttagcgaa 3285061 taaaaggagg aaagccatgt acaaagctga ttataaacag attgctgcaa cgccgtcttt 3285121 tcaagctttt ttaaagcaga aacgcgcttt tattgttcct tctgcgattt tcttttttgt 3285181 tttttatttt tcactccctg ttttgacatc ttatttcacc tttttgaatg caccggccat 3285241 tggagctgtt tcatgggctt ggctgttcgc catcgcccaa ttcgctatga cctggatact 3285301 gagtactgtg tattcccgga gagccgccca tttcgataag tatgtaagcg ctttaaaaga 3285361 ggatctgaag ggtgaacaga catgaatatg actgcttttt tattattttt ggcgattgtt 3285421 ggcctgacgc ttattatcac gtattttgcc gcgaagcgga cgaaaacgac gagtgagttt 3285481 tatacggcgg gcggcgggct caccggcgtt cagaatggac tggcaattgc cggtgactac 3285541 atgtctgccg cctcgtttct cgggattgcc ggaatgattg cgttatatgg atttgatggc 3285601 ttcttttaca gcatcggttt tctggtggct tatctcgttg tcttgtacat cgtggcggag 3285661 ccgcttcgga atcttggaaa gtacacgatg gcagacatga ttgccgctcg ctttaaagaa 3285721 aagaaaatcc gcggtgtcgc ggctctcaat accattgcca tctctacttt ttatatgatc 3285781 gcccagctcg tgggggcggg cgcgctgatc aaactgcttc tagggctgga ttataccgcg 3285841 gctgtcctca tcgtcggagt gctgatgacc atttatgtcg tgtttggcgg catgatcgcg 3285901 acaagctggg ttcaaattat taaagctgtt ttgctgatgg ccggcacact cgtgatttcg 3285961 attatcgtgt tttcgaaatt cggctttagc cttaatacca tgtttgaaca gatgaaaacg 3286021 gctactccgc ttggcgctga ttttttgaac cccggaaata aatacaaggt gccgcttgag 3286081 accttgtcgt taaacttggc actcgtgctg ggaaccgccg ggcttccgca tatattgatc 3286141 cggttttata ccgttaagga tgccaagacg gcccgtacat ccgttgtgtc agcgacatgg 3286201 attatcggtg tgttttacat tatgacggta tttctcggct ttggtgccgc ggcatttgtc 3286261 ggttttgacg cgattacggc ggctgatcaa gcgggaaata tggcggctcc gcttttagca 3286321 aaagcgctcg gaggagactt tctgttcgcg tttgtatcag ccatcgcctt tgccaccatt 3286381 ttggctgtcg tgacagggtt ggtgctgtct gccgcctcag catttgccca tgatatttac 3286441 agccagatca tcagaaaggg agaagcaact gaaaaagaac aaatgaaagc ggccagatgg 3286501 gcttctgtcg ccgtgtcagt gctctcgatt ctccttgcga tttttgcaca atccttaaat 3286561 gtggcgttcc ttgttgcact cgcgtttgcg gtagccgcca gcgcaaacct tccgctgatt 3286621 gtgtttacag tcttctggaa acgattcaat gcctcaggcg ctttatgggg cagcctgaca 3286681 ggcctgatca gcgcgcttgt gctggtatcg atgagcccta gtgtgtggga cccggccgga 3286741 ggtgctattt ttaccggtga tccgctcatt ccgctatcta atccaggaat tatttccatc 3286801 ccgctcggct ttctcggcgc gtggctcgga acggtgctgt cgtctgataa aacaattgat 3286861 gaagatacgt ttgcagaaat tcaggtgaag gcgcatactg gcgtccatat ggaacaggaa 3286921 taaaaaaagc tctctttatc gagagctttt tccttacttt ttcttctgct cgtcagaaat 3286981 cgctttttca aatacatcct tgccggcagc acccggaatt acagtgtcac cgataataaa 3287041 ggttggaacg gctgtgatgt cagcctcttc ataggcgtgc ttcaaggctt ggcgctgcac 3287101 gtcctgatat gttcttgttt ccagtgctga tttgaatgat gcaccgtcta atcccacttc 3287161 ctcggcgagc ttcgtcaaga tgtcaatatc gccgatattt tggtcctcct ggaaaaatgc 3287221 ctgaaagaca cgggtgttgt attcatgtcc tttattgtat tccttcgcaa aatggaagcc 3287281 ttcaaacgcg aggtctgtat acggatgggg cgagacgttt ggaaaattga tctcgactcc 3287341 taatttctcc gccattggct gaattgatgt ctgccacatg tactgtttag aaggatcatt 3287401 gaccggatca agctgaggag atgggcttgg gcgcagttca aacggcatcc actcgacttc 3287461 aacatccttt ccttttatcg cttcttcaaa agcggctttt ccaacaaaac aaaatgggca 3287521 gacgtaatct gaataaactt taatgtgtac tgtcatgata atctcctttc atactaaatt 3287581 gattttaaac tgtaacaatt aaagttacaa ctgtttttta ataaagaagc cgatttaggc 3287641 ttctttcaga ttgatgacaa aatcctaaaa agttttagga ttttgtcatc ctttcagcgt 3287701 gattgaaaac ccttgaagtc taggaaagcc gagcattgga gcggagcgaa tgctctaatt 3287761 cgtgagcacc aacgcacagg cttgacaacg aatgcgaggg tttgtcgaca cgctgaaaga 3287821 agcctgtaaa ggcttctttt atgattccag caaacgctgg gcaatatatt ctcctttttt 3287881 gcagccgcct gggcatgcgt ataaagcaga accgattgtt tgtgtatatt cgtttaacgc 3287941 atcctttgct gaaagagcct tcagcatcgg gataaactga ttgtcgggat ttttttgaaa 3288001 actgataaac aggagacctg catccatata gccggttttc ggatcaagtc cttctgtgta 3288061 agagaaagct cttcgcaaaa tttgtttccc agtagatttc gctagactga cgtgtgaatt 3288121 agacggaatt tgattcagct tcacgggatc tgtttccttt ttctgcccaa aaggcgcccc 3288181 cgagcttttt ctgcggccga aggtatcctc ttggtccttg agggaagagc ggtcccatac 3288241 ctcaaggaac attttgattt tccgaaaagc catataggtg ccgcccgtca tccagtcagg 3288301 ctcaccagac tgaatccaca cgatcgagtt catcaacgtg tcatccttcg tgctctggtt 3288361 gcctgttcca tctttaaacc cgaagaggtt gcgcggtgtt tcaccatttt ttccaccgct 3288421 taaaaagcct ttgttcacaa aacggacctc acaagtgccg accgcttgat ttagcaggtt 3288481 acgcagcgcg tgaaacgcca cttgctcgtc gtctgcacac acttgaatgc agatgtcccc 3288541 gcctccctgc ttttcatcca ggttgtcatt gggcatcgct ggaagagcgg ctaggtgctt 3288601 cggttttttg cttttcagtc cgaagcggtc ctttccgtct ttttcaaaaa agccaggccc 3288661 gaatccgaat gtgaccgtta agttggaagg ggataaatca gcagactcac ctgtatcctg 3288721 cggcggcaga tactgatttc tctgctccgc tgacattttc ttgccagacg tcagcatctg 3288781 tgtgagactt gtccagtttc taaataacgt aatgatgtcg cttttgtctt ttgctgttac 3288841 atccagtgca gcaaaataga catacgtctg atgggcagtt gtgattccgg cctgatgctt 3288901 tccgtaaaac ggaacaatct gctcctcctc tttttcatcc tttttcgatg gcttagccgc 3288961 agtctgaaca agcggagcga gaccgccgag accgctggca ccgatcgcaa cggctgcccc 3289021 cgccatcgct ccccatttta aaatgtcccg tctgtgaatt tgttctggct ttttctgttc 3289081 atcgctcatg atgttacaaa actcctttta tagcacattc gcaatcttcg acatggtttc 3289141 agaaagagtc gtcagcttag tgctcagctc tctgatttgc ttttcactta atttatcata 3289201 agacgtatag gactgatcat ttgttttgta ttttgccatt aaaacttcaa attcgctgaa 3289261 ctccgtatcc agtttttccg tcaagtcgga gtgatctttt acaagcgcgc ttttcactgt 3289321 ttgataaacg gcttcggagc cttccacatt tgccataagg tcaactaaat caattcgtga 3289381 gtagcgctct tcttctcccg tgattttcga aattccggct tcgttcagaa gctccatcgc 3289441 gcctgcaaca atttgttcag gtgttaattt cagtgattga attgaaccgt caagctcttt 3289501 tacatccttg agaagctggt cagctgttgc cttttccccg gaaatatctt gatccttcca 3289561 aatggccttc tcaagcttat ggaagcctgt ccatttgtct ccttcttcaa catcgttttc 3289621 tcgtgcgtca attttcggat caagatctcc gaggctttca gcgatcggtt cgattcgctc 3289681 gtaataaaca cgcgctttcg catataacgt tttggacttt tcgatatcgc cggatttcac 3289741 agcacccgta aatgcttcag tcgctttgac aagctggtca ctctgctctt tgacatagcc 3289801 tttatactca tccgctgctt ttgccagctg atcgctagcc tttttgccgc tcttcttcgc 3289861 ttctgtcagg tcttctaagg atgctttcaa tgactcggat tctgtcttga tttttcctgc 3289921 atccggtttg tctttttgcg cttctgtgta gattggctga agatgctttt cgatttctgt 3289981 atattcgaat ggatagtcgc tgcgaatatc gttttcaaag gaaagccagt agctgtttaa 3290041 ctctttcccc ttcttttcaa tctctttttg gtctcctttt tccactgagt cattcagctt 3290101 agaaatgatg gtttccattt tatttacgga tgcggtgatt tctttagtga ccccgctttt 3290161 ttcagatgaa gctttttctt tggttgaaga tgtgtcattg gctccgcagc ctgcgcacag 3290221 cgcaaggatg catccggctg atacagcgat ttttgtgaaa ttcattttgt cagttccttt 3290281 ccgtttgtaa aatgttttgc cgcttctgaa acaagcgcaa tcagtaaaaa gagtaaaatc 3290341 aacatttgcg gaatcgtgct gtacacagac ggataaattc ctagcaccga tacagacggc 3290401 agccagcttt ctgcatcaga cggaagaatg cccgccagtt gaaggctgtg aacgccggtt 3290461 ccgagaaatt tcacgcacat atacaggaca accgccattg atagaagaaa aaacggcttc 3290521 aatggaatgc gcattccgag cttgatcatc agaacaccga cgatgacgag aacgataagc 3290581 cctgcggcag ttccgccgat cagttcagtg agcgggagct tcccgacaag cccgatgaaa 3290641 aagatgaccg tttcgagacc ttctcttaca actgccagaa atgcaatgag cgcaaaggaa 3290701 agcaggcttc gtttttttag tgcctgtgac ttctggatat tgattttttc tctccattta 3290761 tccattgagg cgtttctgtg cagccacacc ccgacataca aaagcatgac agcggacagt 3290821 acgccggtaa cgccgccaag caagaaattg ttttctccga atacactgga ggagaacaga 3290881 accgtgacac cgatgccggc tgctaaggaa acagccatgc cggcggacgc cccgccccag 3290941 atccatgtcg aggaacgcgt aacccgcgct ttttttgtca tggttaatag cgctccgatg 3291001 acaaggaggg cctccattcc ttcacgaacc gggatcagcg ccgcatccca ccagctgtag 3291061 ctgcttgaag cgatcggctc gagcaattga atcatttcgt caatttgctt tgataccttt 3291121 tcaggatggc tgccgatctc cgccttcatc agcgccagat tttcctccga tgtcgtatag 3291181 gcttctttcg attgggacac gacatctccc tcaacagcga gccaggatgt aactaaattg 3291241 tcgattgcgg atgacgcttc atccaattgt tttttttcta tgaactgttt tgtgtctttc 3291301 aagctttgta tataggctgt taaggacgcc cttgattgac ctgaggatgt ctttttcagc 3291361 acgacagcct gctgataggt ttctaaatga gacgcaagct cttcaagctg tgttttgagc 3291421 ttacgtgcgt cttgattgat aaaagaaaga gaaatcatcg cgatattcgc gtccatttca 3291481 ctgtgagaag aaaggttttc tttcttaata gaaggttctt cttttttcca cttcgccttg 3291541 aaggtgtcaa acgtttgttg tgccgaatcc atatccccgt cttttacgga tttgatcatt 3291601 tgcttgttta attgaattaa tgcggcgatc ggatcatctt ccgcatgtgc cgcagaaccg 3291661 aaaaccatca acaagctgaa tagaataagt gccagccccc gagccatcat gttcctccta 3291721 taattgaaaa tgattatcat tgtataacat aatcatagcc agttcctgtc ctttgtcaat 3291781 taaaatttga aggtctgaaa accttgatgg acagcaaaaa agctgtcctt ttacagaaca 3291841 gccctttgaa ggaaaatgaa cgattatctt cctgttttat acgtttgaat ttcctcacga 3291901 aacttgcgtg cagcactctc aggatcctcc gcctgactga tggcgctgat catactgacg 3291961 ccatcggccc ccgcttggat aacaggtgcg gcattatcta ttgtgattcc gccgatgccg 3292021 acaattggaa tgctgatgcc ttggcggcgc actgcttcga taagagatac accctgtacc 3292081 gctctcgtat cttttttcgt ttcagtcgga tagatcggcc caagcccgac ataatccgct 3292141 ccgtcttctt cggcttgctt cacctcagac atcgtatggg cagaaacgcc gagaatcata 3292201 tcacctatgg cagctcttac ctctttcgca tttgcgtctt cctggccgat gtggatacca 3292261 tcagctttca gattcagagc caattccaca tcatcattga caatgaacgg aacaccagct 3292321 tcacggcaag ctgcctgcgc tttttcagca aatttaatcc gagcctctcc tgtcagcgca 3292381 tccccgcctt tttcacggaa ctggtacagg gtggcaccgc cttttaacgc tttttgtaca 3292441 actgtaacag gatcggcttt cgtattgttt gaccccataa tgaagtatac agataataac 3292501 tctttcatca tttcccgaga aatacgagtc atgagacagt caccctttct atagtcgccc 3292561 attcttggac gtcttgttca gtaacagttg aaagcttgtt cagcaattca atctgaaagc 3292621 ttccagggcc tttgtcagcc gtctgctgtg cggcaagctg agcggcgacc ccatacgaag 3292681 aaatggccgc aatagcagca aacaatggat tttcttccac agcgcaaaac gcaccgacga 3292741 cggaagtcag caggcaaccg gcgcctgtca cttttgtcag cagcttgtgg ccgttatgaa 3292801 gggtgtatac atgtgacgtg tcggctatga catcaacttc accagttatc gcaatgaccg 3292861 tgtttagctt ttgtgccgcc tgctgagcca gccggatgat gtcgcctcca ccttcacccg 3292921 catcaacacc tttgatcagc caatcggtca cgccgacggt atgggcaatt tccgccgcat 3292981 ttcctctgat tgcagcaagg cgcacctcac gaatgatgtc acgtgccgat tcagtgcgga 3293041 acggtgttgc tccggcaccg acaggatcaa gaatgacggg aacgccatgt tcattagctg 3293101 attttcccgc gatgatcatc gcttcgactg actccttgct cagtgttccg atatttaaaa 3293161 cgagtgcacc cgcaattttc gccatatcgg cgacctcttc ttttgcgtac gccataacgg 3293221 gcgatgcgcc gagcgcgagc aggccgtttg ctgtgaaatt cgttacgaca ttgttggtta 3293281 tgctatgcac cagtgggcta tgccggcgga cagccgtaag acattttgct gctgattgtg 3293341 catccatatt tgcatcatcc tttactatct tttttcgggt cccataaata cgatttcgta 3293401 tgttcgagcc aagctctggc ggcaaacgac aagtacctgt cctttctcca aataatggcg 3293461 aggtgccaag ggatgaccgg atcgacaagc ggaatgactt tcactttttc cgggtcaagg 3293521 ccgcggcaga tccgttccgg caaaagcccg atcccaaggt tggcggatac catctcacta 3293581 ataaaatccc attgtgatgt ttcataaatg atatggggcc ggaacccagc cttgatacat 3293641 tccgtcataa ttcggttgtg caggacaaaa tcctctctga agaaaataaa aggctcgtcc 3293701 ttcaactcac gcagctgaca ttctttctca tcagccagcc ggtgggaagg gtgaacgaca 3293761 agcattaagg tttcttttac gattgtaaac gaatgaaaga tatcttcgtt tgcgggaagg 3293821 accacaacgc cgatatcaag agagccgtcc ccgacacctt cttggacttt tatagaaccg 3293881 tcttcgacta gctgaaaggt gacattcgga tagttttcac ggaaatcgcc gagcactctg 3293941 gggaaaaacc ccgatccgat catcggcggc agtccaatcc gtacgtgccc tttcttgact 3294001 tccataatat catttaattc tgacgtcagg ttttgaaatg atttaatgat ttcctgcgcc 3294061 tgcacataca tgctatgacc ggcatcagtc agttccacct gcctgccgtt tcggtaaaac 3294121 agttcaattc cgagctcttc ttctaaattt ttgatcattt ttgatatcgt cggctgagaa 3294181 acataaaggg attgggaagc cttcgtaaaa ctttttaaac gggcgacttc caagaaatat 3294241 gttaaatggc ggatatccat gcgcttcacc ctttctatag acaaaaggaa tacttcttat 3294301 tcttaatata tattttacct atagagagac cttatgtaca ataagtatat aagggaggca 3294361 tcaatatgaa aaaactgttg ctaaccgtta ttcaaatcgc tctgttattt atatttgctc 3294421 ggctgattaa ttgggtgaca gcccttcttc atataaatat tcccggcagt ataataggga 3294481 ttgtgattct tttcacatta ttgcacttta acattatcaa gcttgaatgg atcgagcttg 3294541 gtgcagcgtg gcttctcggg gagctgcttt tattttttat cccgtctgcc gtcggagtga 3294601 ttgaatacgg agacattatg tcgaaatttg gtgtcagcat tctgcttgtt gtcatcatca 3294661 gcacgtttgt cgtgatggtg tctacaggaa cgcttacaca actcatcgca aagagaaagg 3294721 agaaaaagca tacgtgttca tcggaattgt aagtttgttt ttaacggttt tggtgtattt 3294781 aggagcaaaa aaggtatatc aacgctttcc gcgtgtttat acgtcgccgc tattggtgac 3294841 gcccgctgta ttagtcggtc tgctgctgct ggtgaatgtc ccgtacgagt cctataatct 3294901 cggcggcgga ttgctgaccg atatgctaca gccggccacc gtggcattcg cgatcccgtt 3294961 atataaatat ttccctgttt taaagaaata cgcagtggaa attattttga atgtggccgt 3295021 cggttcatgc atcgcgatta tttctaccgc tcttattgcg aaatggcttc acctcggcac 3295081 cggcttaatt gacagcctcg tcccaagatc agtgacaacg ccgatcgcga tgaacgtatc 3295141 tgaaatgatc ggcggtatgc ctgccgtcac agccgtgttt gtgattttaa ccgctttgct 3295201 cggcacagtg atcggcccga tggtcatccg ttatttccgc attgataacg aaattgcgcg 3295261 gggcgtgctg cttggcacaa gcgcgcacgg agcgggaacg tcaaaggcat ttgagctcag 3295321 ctctgtgtcc ggcacgattt ccagcgtgtc gatgatctta gctgcgatta tgacgctttg 3295381 cgcggcgccg tttttgcttt catttatgta aaaaactgtc ctctcgaggg cagttttttt 3295441 tatgtgcttc cccttattga aaagctggcg aattccaata taatgtattt gtggatacca 3295501 aaggaggcac cctgatgcac aacttgcagg tgaggcggca ttatgccgcg ttaaaaggat 3295561 tttatttgtt tgcttttctc ggtacgggca gcataattcc cttactcagt atgtatttaa 3295621 cgaaggaaca gcatttaagc ggatcacagg tcggcttgat catgtcactg ggcccgattg 3295681 tgatgatttt ctttcagccg ttttggggca tgctgagcga ctatacgcaa aaaacgaaag 3295741 gcctgctggc ggtttgcaca tcaatcacag gcatcattgg attagcctat attgcatttg 3295801 acagtttccc tctgtttatt ttgattgcgg cctgttttgc agcctttcaa agcacgatta 3295861 ttccactttc ggacagcatt tcactaaggt acacacaaga aacaaacggc aactacggcg 3295921 gaatccgcct gtttggttct ctcggcttcg gtgtcgcggt gtttgccatg ggacaggtga 3295981 cgaaccagct gtaccccatt cacgtgatct ttatctttgg ctgtgccttt ctgtgcattg 3296041 ctgccatatt ggcttcacaa gtgcccggcc agcagaaaac aacaaaggtc aatatccgca 3296101 aaggattccg ggagcttatc agcaacaaaa ctttcctcat ctttatgatc atcaccttta 3296161 cgacatttgc tccaaactta gcgaacaata cgtatttcag tctttttctg gacaaaagcg 3296221 gcgcgtcact ttccgctatc ggcattttat ttttcatcgg tgtcatttca gaaattccat 3296281 ttatgagatt cgcccaaaca tttatagata aaatggggct gctcaacgtc attatgctgt 3296341 caggcggagt ctcattattc aggtgggcgc tctatttcac ggcgccttca ctatggatca 3296401 tttatgcgac ggtctttctt cagggagtgg ccatcggttt atttatcccg gcggcgcttc 3296461 aatatgtgaa aaagattacc ccaagacacg ttgaagcgac ggcgctgacc atgtacgccg 3296521 ccattggcaa cgggttcggc aactggttct gcacatttgc aggcgggtac atttttgact 3296581 acgtgtcgat cttcgcagtc tacttgcttt ttggcattct gagcatagca ggctttggcc 3296641 tgacattata tttaatgaag gctgaaaaaa acaaacatac acttcatcag ccggctgtta 3296701 cttttaaacc ataatgacta taatgaacaa aagaaaggat gtgcgttatg aacgggcaag 3296761 agcgaaacag catttcgaaa gggttgcagg ttgatattgt attgaaagca gatcaaaaaa 3296821 caggaaaact gacgagaggg acagtgaagg atattttgac gaaatcaaac tttcatccgc 3296881 atggcattaa agtccgtctt gaagatggcc gcatcggccg cgaccagcag atcgtttcta 3296941 cataaaaaaa agctgcccct gaacagggca gctttttcat tattttttct gcagaaggac 3297001 cactttcagg tagttgcctt ccggaaatgc cgaaatcgtt ttgaaatcct ccggcagcgt 3297061 aaattcctca atgatcgtgt agcgttcatt tgtttcttta aaggcggcat caataaagcc 3297121 tttgaacttc ttcatgccaa aggcgctgct gtttgtagag gcaacaatga cacccttgtc 3297181 agcagtgatg gcgatcgttt ccttcagcag gtttttataa tccttggccg cgctgaaggt 3297241 gcgttttttt gtgcgcgcaa aggaaggcgg atctagaata atcagatcaa agcgcaaatc 3297301 cttttttgca gcatatgaaa aatagttaaa aacgtccatc actttaatgt cgtgcgcttc 3297361 gtaatccagc ttgttcacgc tgaattgctc gatcgttttg gcaagacttc gatttgccac 3297421 gtcgacgctt gttgttttct ccgctccgcc aagcgccgcc gccacggaga atgcacccgt 3297481 ataagaaaac gtatttaaaa cggttttccc ttttgcatag cggtctctga tcgccttgcg 3297541 cacatgtctc tgatccaaaa agatgcccgt catggcgcct tcattcagat ccaccgcgta 3297601 ttgaatgcca ttctcttgga tgatgatcgg gaactcgccc cttctccctt tcacgaagtc 3297661 atcatcttca acgtattgtc cagccgtgtc gaagcgtttc ttctcgtaaa tcgctttata 3297721 atcaagatcc atctcatcca atgcggaaat cagcatgtct ttaaaggtgt aaattccctt 3297781 gctgtaccat tgaatcagca ggtagccgtc ataatagtcg atggtgacgc cgccgacacc 3297841 gtcaccctca ccgttgaaca ggcggaaagc tgttgtatct tgagcctcaa atagtttggc 3297901 gcgcgcttgg gccgcttttg ttaatttgct gagaaaaaat gcttggtcaa tctgttcatg 3297961 tttattgcgg gtaagcgtcc agccaacccc tttgttttgc aggccgtaat agccccgcgc 3298021 gagaaactcg ccgccgctct cagacacgat atcaacgagg tctccttctt tcatgtgccc 3298081 cgcactccct gcgagagctt ctttttcaat aaggggatag ccttttttta ttttggcagc 3298141 gtgtgctttt tttagggtga gtagcttcat atatgtcgtc ctctttccgt ttgctttctc 3298201 ttatggtacc acaaaacgcc aagatgtctg cattgacaga aaggaaaggt ttttctacga 3298261 tagacaaaaa gagttacgag gaggagcagc atggcaaaac gaattgacca tacaggcatc 3298321 atggtaagag atattaacgc gtccatcaca ttttatgaag aggtactagg catgaaattg 3298381 aaggatcgca tcactcacac gaacggtgta atcgagcttg cttttcttgg ctttgaagac 3298441 ggcccggaaa cagaaattga actgattcaa ggctacagca gcgagcttcc cgctgaagga 3298501 aaagtgcacc acattgccct gctgacggat gacatcgcgg ctgaatatac aaaagcggaa 3298561 aaaatgaacg caaaatttat cgacgaggag atcacaacac ttccaaacgg ataccgttat 3298621 ttctatatcg aaggccctga cggtgagtgg attgagttct ttcagcggta aaaataaaga 3298681 acgtacattt tgtgatgtac gttctttttt atctatacca actgatatac ggctatacag 3298741 ccatgaacag cataaaatga acgttattac agttatcacc acatatggcg ggattgtgac 3298801 tgggcaggca ggcaagaccc aatgatgcaa agggagtatt aatgcctaaa aaacagggca 3298861 ttttaactct tcttttcgtg ttgggctcat aacggcgcct tggacaaccc cctattctca 3298921 tgctccgtcg tcgacgcggg catttttgtc attttcagcc ggtatttctc acttttttca 3298981 ttttgattgt caacttttca tttgatacga tgaacaagcc gacttttctt cagcaaagga 3299041 ggttttaatt gcttgcataa agagattgca aaagaattac tgctgctcgc aggaggaaaa 3299101 aacaatatta tcagcatcag ccattgtacg acccgtcttc gttttgatgt aaaggacgag 3299161 acgaaaattg atatacatgc cattgagaac ctgcaaggtg tgcagggcac ctttttccgc 3299221 tatgggcttt tccagattat cttcggagca ggcgtcgtca acaaaatata taaagaagtc 3299281 gttcatgtat gggagaccgc gccttctgaa gagcctgtcc accagaaaaa agccagccgg 3299341 aagctgaacc ctgccgcagc ttttgcgaaa acactgtccg atatttttgt gccgattatt 3299401 ccggcaataa cagcaagcgg cctgctcatg gggctgatcg gcatgattaa ggtgtttcat 3299461 tggttcgctg ccggcagccc atggattaaa atgctcgacc tcgtgtccag cacagccttt 3299521 attttactgc cgattttagt cggcttcagt gctgcacggc aatttggcag caacccatac 3299581 ctaggggcag tgattgcagg gcttttgacg catcctgatc tgctggaccc gtctatgctc 3299641 ggcagcaaaa ccccgtcttc tttagacata tgggggcttc atatcccaat gatgggctat 3299701 cagggttcca tgataccgat tcttctttcc gtttttgtca tgagcaaaat tgagaagcta 3299761 ttaaaatcga ttgtgccgaa gtcgcttgat gtcgtgatca ttccctttat tacggtcatg 3299821 gtgacagggt gcctcgcgct gattgtgatg aatcccgccg cgtccatcat cggccagatc 3299881 atgacacaat cgatcgtcta tatttatgat cacgccggca ttgctgccgg agctcttttc 3299941 ggcggcatct actccaccat cgtcctatct ggattgcatc atagctttta tgcaattgag 3300001 gcaacgctgc ttgctaatcc gcatgtcggt gtcaactttt tagtgccgat atggtcgatg 3300061 gcgaatgtgg cccaaggcgg agcggggctt gcggtattcc tcaaaacgaa acaatcaagc 3300121 ctgaagaaaa ttgcgctccc cgcttctctg accgcgtttt taggcattgt tgagccgatt 3300181 gtattcgggg taaatctcaa attgatccgt ccctttatcg gagcagccat cggcggtgct 3300241 attggcggag catacgtggt tgcggtacaa gttgtggcaa attcctacgg actgacaggc 3300301 attccgatga tttcaatcgt gctgccgttt ggcgccgcta attttgttca ttatatgatc 3300361 ggtttcttga tcgcagccgt ctctgctttt atagctacat tgtttctcgg gtttaaagaa 3300421 gagacagaat aactggattt attcgatttc attcataaaa cgggggatga aaggacaaaa 3300481 aagctatgaa aattaaaaga atcttaaatc ataatgctat cgtcgtaaag gatcaaaatg 3300541 aagagaagat tctcttgggt gcaggaattg cgtttaacaa aaagaagaat gatattgtcg 3300601 atccgtcaaa aatagaaaaa acctttatca gaaaagatac acctgactat aagcagttcg 3300661 aagagatttt agaaacattg cctgaagacc acattcagat ttctgagcaa attatctctc 3300721 atgccgaaaa agagctgaac atcaaaatca acgagcgcat tcatgtcgct ttttcagacc 3300781 atctttcttt tgcaattgaa cgcctgagca atgggatggt tatcaaaaat ccgctgctga 3300841 atgaaatcaa agtcctttat ccaaaggagt tccagatcgg cttatgggcc agagcactga 3300901 ttaaagataa actggggatt cacattcctg atgatgaaat cggcaatatc gccatgcata 3300961 tccacacagc aagaaacaat gccggcgata tgacacaaac gcttgatatt acaacaatga 3301021 tccgtgatat tatcgagatt atcgaaattc aactgtctat taatatcgtt gaagatacca 3301081 tctcttatga aaggctcgtg acccatctcc gctttgccat tcagcatatc aaagcaggcg 3301141 aatccattta cgagctggac gcagaaatga ttgacatcat taaagagaag tttaaggatg 3301201 ccttcctgtg tgccctaagc atcggcacct ttgtgaagaa ggaatacggc tttgagtttc 3301261 ctgaaaaaga attgtgctac atcgccatgc atattcagcg gttctaccaa cggtcagtcg 3301321 cacgctgaga caaacaaaaa acgcttttga tcatctcaaa agcgtttttt tatctgattt 3301381 attggttgat cgccggattc ccaatcgtat tccacttcgt ataggacatg taatggaaat 3301441 actcatcgcg atacggatgt tttgtattgg agttccaagg cttttctccg ccgcagaagt 3301501 gcacgattgc cgggttttct cttgtttcat tatattgctt ccgccctaac agagtcgatg 3301561 gggttttcag ctttaacatg atataggttt gagcgttcca gcgcggatga agttcatacc 3301621 actgatcata caagatcgca ttcagtgcat cttggtcatg cagcacaaga aagtcttcgt 3301681 ctgggtgttc attgataaag ttgatgactt tttctgtgat gttttgcttt ctccaagact 3301741 caaaatcaat aatcatgata cctgagttaa aatacttccc tgtatcagtg acgttcattt 3301801 ctttcaggcg ttcatgctgc cccgcatcct caacagcggc tacggtgtat ggcgcaatgt 3301861 ctaagtccca tagcttagaa atatcctcta ggacaagcgc atcacaatcg atgtaaatca 3301921 ttcgtttgat gctttcatcc ttaattaagt cgggaatcga aatgcggtaa tacgcggctt 3301981 ttgtaatatg gctgctctca accgcatgtt catacatgtt ggtatccact tctaaaaact 3302041 caatcggcac tccgaatttc aaagtggttt cttccagtct ttttttgtta tcaggcttaa 3302101 ttccgccatc aatgacgtat aattttacct ctctctcctg atccatgtta gtcaataaag 3302161 aaacgaacat cccacctaaa tgacgagcat aattatcatc tgcgcatgat acgatatgca 3302221 tgatttcatc tttcctcaat ggtattcatc tccctttttg ttgtacaagt tacataccct 3302281 ttttcaaaaa aataaacacg ttctccgaca tttttttaaa cagaatgtgt gatacaacaa 3302341 aaaaggtgtc attttttgaa gatgcgataa agccaataaa gaatgaaaaa gcttgcgatt 3302401 gtgatggctt cagccgagac gatataccac ggccatggcc cgagaacatc taagagagag 3302461 gaaccgcccg gttttttcgt caaatacata taattcgcgc caagccagcg atcaatcaga 3302521 aaaatacaga cgccgtacac attaacaagc aggactgtca cccataacga gcgctggccc 3302581 attctgtagg tgccaatcac agccatcagc agacaggata aaaacacaga cccgtgagaa 3302641 ataaaaaaga ggatatatcg gatatgcgga aatgaaaaca taccgaggtc aggagtggca 3302701 agagcctgaa tcgaactgcc gatgccgaca aaaaacaaaa acacaaacag ctttctgctt 3302761 tttgtcacta acataatagc tgacaaatac accgacaggt cactaagctg gagaggcaat 3302821 gaagtgcgca ccgaccacct gtccgtggcg accatccata tttgatagcc gatttgcgaa 3302881 ccaagcaaaa gaaacacaaa cagagaacgc aaaaaccggc tggccctcgg ctgcttgacc 3302941 tcatcttgga acaaaaacaa cagaatggcc aaaagggaga taatcgctaa cgtcactaca 3303001 tgctctgtcg aaaacagatg aaacggatca tgcttatagt cggattgaac atatttttgc 3303061 aaaactgcac ccccgttttc gggtttttgt ttattttggc gttgtttggg ctttttttat 3303121 tcaaccgata tatgggcttg aagttcacac cagactctgt taaaattcgt ttcatagcta 3303181 atgattctga taatttaagg caggcctaaa aaatggaacg ttcacatcaa catcagcagc 3303241 ttcggaagga agaacacgat acactttcta agctcaaaca aatgcccgtc gagtcactca 3303301 acctggaagc catttcgatc gctacgaatc tgtatcggtc tgcacaaagg ctccgtgtca 3303361 aaatggagac tgaggttctt tctacctata acctttcttg gaccgctttc tccattcttt 3303421 atgatctatg ggtatgggga gcgctcgaaa cgagaaaaat cgctgagctg tcagggatat 3303481 ctacagctac agcaagcaac gtgatcaaaa cgctcgaaaa aaagagtttt tgccgtaaaa 3303541 gcatcgacac aagagatcgg cgactcgtgt ttgtctcaat caccgattcc ggcaaacaag 3303601 cgatcgaaga actctacccg gagtttcaca aaggggaaac agagctcatt gcgggaatga 3303661 cgaaggacga acagaaaata ttgacagggc tgcttagaaa ggtagctgac aatcttcata 3303721 caacataagc tttgacggga atccagtagc ggtttgtctc cctgtttcag agagccggcg 3303781 gtaggtgcga gccggcgcac aggcaaacgt gaattacctc cccaagcttt ctttgtgaac 3303841 cttagtagca aagaacggga aaccgttatt cgaatgagcg gaagacaatg tcttcaacca 3303901 gggtggtacc gcgtgcattg agccacgtcc cttattggga tgggctcttt tttgtgtttg 3303961 taaaaaagga ggaaaaatga tgagaacatt tgagcagctc acagcgtcac aacaaaaaga 3304021 ggtagaaaga cagcttcagc tatacatgac aggcgcccac gaagtcatac cgccggagga 3304081 attaaaggca aagctcgtga aatcaatttc cacgggcacg ccgcttaaaa ttaagctcgg 3304141 attagatccg tctgcaccgg atgtacattt gggccatacg gttgtgttaa ataagcttcg 3304201 ccaatttcaa gaaaacggcc acattgtcca gctgttaatt ggggatttca caggaaaaat 3304261 tggtgatccg accggaaaat cggcagccag aaagcaactg actgatgaag aagttcagca 3304321 caatgccaaa acctactttg agcaattcgg aaaagtgctt gatccagaaa aagtcgagct 3304381 tcactataac tcaaaatggc tgaaaacatt gaatctagaa gatgtcattg aattagcagg 3304441 gaaaataacg gtagcccgcc tgatggagcg cgacgacttt gaagaacgca tcgccatgca 3304501 aaaaccaatc tcactgcatg aattctttta cccattgatg cagggctatg attctgtcgt 3304561 tctcgaaagt gatattgaat taggcggaac ggatcagcat ttcaatgtcc tcatgggacg 3304621 gcatttccaa gaacgataca acaaagaaaa acaagtcgtc atccttatgc cgctcttgga 3304681 aggcttggat ggcgtcgaga aaatgtcgaa gtcgaaacac aactacattg gcattaacga 3304741 acatccaaac gacatgtacg gaaaaacgat gtcactgccc gacagcctga tgaaaaagta 3304801 catccacttg gcgacagact tagagcttga agagaaaaaa cagctcgtaa aagacttaga 3304861 aaccggcgcc gttcatccgc gtgatgccaa aatgctttta gccagaacaa tcgtccgaat 3304921 gtatcacgga gagaaagcag cagaagctgc cgaacactcg tttaaaacag tctttcagga 3304981 aaacagcctg ccggaagata taccggccgt aaactggaaa ggcgaaaaaa cgatagcgat 3305041 gattgatctg ctcgtcaagc taaagctcct ctcttcgaag agcgaggcgc gccgcatgat 3305101 tcaaaacgga ggtgtacgca tcgacggaga gaaagtaaca gatgttcacg ccaaagcaga 3305161 gataagagag aatatgatca tccaagtcgg caaacgcaag tttttaaagc tccaataatc 3305221 tgatattccg aaacgcttat gacccttcat tcataagcgt ttttttgcag gtataaagca 3305281 ctgtcttttc aaaaacgctc tccatcttgc aggaaactcc tttagcatcc cgaaatattc 3305341 cccaaccata catttagggg aggtttattt ttgatgaaaa agcttttgac tgtcatgacg 3305401 atggctgttt taactgccgg cacactgctc ttgccggcac agagtgtcac ccctgccgcg 3305461 cacgctgtac aaatatcaaa tagcgagcgc gagcttccat tcaaagcaaa acatgcgtac 3305521 tctaccattt ctcagctaag tgaagcaatc ggccccagaa tagccggaac tgcagctgaa 3305581 aaaaagagtg ccctattgat cgcctcatca atgagaaaat taaagcttga tgtgaaggtt 3305641 caacgattca acattcctga ccggcttgag ggtacactgt cttcagcagg acgcgatatt 3305701 cttctccaag cggcgtcggg ctcagctccg actgaggaac aagggctgac ggccccgctt 3305761 tacaatgcgg gattgggcta tcaaaaggac tttaccgctg acgccaaggg caaaatcgcc 3305821 ttgatttcca gaggagacct gacttattac gagaaagcca aaaatgccga agccgccgga 3305881 gcgaaagctg tcatcattta taacaacaaa gaaagcctcg tgcctatgac gccaaacctg 3305941 tcgggaaata aagtcggcat tccggtcgtc ggcattaaga aagaagacgg cgaagcactt 3306001 acccagcaaa aagaagccac cttaaaacta aaagcattca caaaccaaac ctcccagaat 3306061 atcatcggaa tcaaaaaacc aaagaacatc aaacatccag acattgtgta cgtgaccgcc 3306121 cattacgaca gtgttccttt ttcgcccgga gcaaatgaca acggctcagg tacctctgtt 3306181 atgctggaga tggcgcgtgt cttaaaaagc gttccatctg ataaagaaat ccgctttatc 3306241 gctttcggcg ccgaagagct cggcctgctc ggctcctctc actatgtaga tcatctatcg 3306301 gaaaaagagc tgaaacgaag cgaagtgaac ttcaacttag atatggtagg cacaagctgg 3306361 gaaaaagcgt ctgagctgta tgtcaacaca ttggatggcc aatctaacta tgtttgggaa 3306421 tccagccgta cggctgctga aaaaattggg tttgacagcc tgtctctgac acagggagga 3306481 tcatctgatc atgtgccatt ccacgaagcc ggcattgatt ccgctaactt tatttgggga 3306541 gacccggaaa cagaagaagt tgagccgtgg tatcataccc ctgaagactc gatcgaacat 3306601 atcagcaaag aacgcctcca gcaagcaggc gatcttgtga cagccgctgt ctatgaggct 3306661 gtgaaaaaag agaagaaacc gaaaaccatt aagaaacaaa tgaaggcgaa agcatctgac 3306721 atttttgaag atatcaaata aaaaaagacg gcacttgggt gccgtctttt ttaatccact 3306781 tctttcttaa tccccagcat tttctcatct aggtaatggg caatctccgc ggcttctttc 3306841 agctcatctg ttaattgctt aggaacgtca ttgttcaatt tataataaat tttatgttca 3306901 aggctcgccc agaaatccat cgcgattgtc cggatttgaa tttctgcttt gacgtattcc 3306961 acacggttcg ttaaattcac aggcatctca atgattaaat gcaggcttcg atagccattc 3307021 ggtttgggtg tctggatata atcctttacc tttacgattc tcaaatcttc atgctgcttc 3307081 aacacattca cgacattata aatgtcagaa ataaaggaac agatgatgcg cacgccggca 3307141 atgtcgtgaa tatgctcctt catttccttc gtcgtaatct cacagccctt tctcattaac 3307201 ttattcacga tgctttcaaa gctttttaca cgggattttg tatgttcaat cgggttgtgt 3307261 ccgtgaatga ggttatattc ctggctgata attgagaact ttgtatcgag cgcatctagc 3307321 gcaaatttat aaactaataa ctcatttttc caatcttcca ttactgtttt taaatcgtcc 3307381 atatgtgtta cagataaatc catgttcgtc atctccttta acggaacttt atccgctgtc 3307441 catgtactag acgtccctgt ctgctgcaag gttctatgaa tttttttaca aaatgcggtc 3307501 gattgtaaca aaaaaagacc gcatgaaacg agcggtcttt tttattatcg gaaatagctg 3307561 atcaataatc cgatcgagag caggaatccg aaaaatgtat ttgtttgggc tgttgatttc 3307621 attgcgacaa tcatattcat cggcatttcg ttctggacga agcccttcac tgcctgaacc 3307681 ggcttaggca cgctcaaaaa gacgacaaac agccatgggc ttgcggcacc ggtaataacc 3307741 aagccgacaa cccagatata agcgacggca aacgacgcag ctaacagagt aacagctccc 3307801 ttatgcccca tcaaaatcgc caatgttttg cgtccgcctt ttttgtcctc ttcaatatca 3307861 cgaatgttgt tcgacaggtt aatcgcgccg acaagaatcg caatcgggat ggaaatcaaa 3307921 atgctctgca tattgatctt atctgtctga atgaaaaacg aaatcagcac aaacaccgaa 3307981 cccatgcaaa tgcctgagaa taattcaccg aacggcgtgt acgcaatcgg cagcggcccg 3308041 cctgtataca ggtagccgat cgccatgccg acaaggccga tcagcgcaag ccaccagctg 3308101 ctgctggcac aaatatagac accgagcaaa atggcaatcc cgtatgaggc aagagctaat 3308161 tgcaaaatcg ttttaggctt cattccgtgg cgtacaatgg cccctccgat tccgactgat 3308221 tctgctgtat ctaatccgcg tttaaaatca tagtattcat taaataagtt cgtcgcgatc 3308281 tggatccata ggcaagaaaa cagcatagcc aaaaacagca gcagatcaac cttcacataa 3308341 aacatcgcca aaacggttcc gagcagcaca ggcacaaacg atgcggttaa cgtatgagga 3308401 cgggttaact gccaaaggat ctgccccatg ctttcttttt gcggcgctgt ctgaccctca 3308461 cccttatttg tttggttcat cttcctcttc ctttctatta aaaggcttac tttttttcag 3308521 ccggcagctt aataaaaaac tccttttgct tccttatcta tcataatgac ttctccctta 3308581 tttcacaaga taccgcaaga aggcgttttc tttcttatta tacgcttctc gccctgattt 3308641 cattaggttt ctgctttcac ttgaacgaac aggtacagaa aaattttttt aagtacatta 3308701 cactttttaa aagttaaaaa gatcttttga ctccaggtat cttttccttt attatgaatc 3308761 agctcgaaac attccattct tgcccttgca ggtataaaga ttcattttca aaaacatacg 3308821 ccgatatatt aatttgaggg agattaggga aaaaatgaaa ctttttgagc atctgatcgt 3308881 caaataatca tgtgattgtc gaaaaaacgg gaagggaatt tttgatatgc tgcaattaat 3308941 gaaacagctg tatgaaaaac ccgctgtcaa gtggacatgt catacaggct tttatttgat 3309001 gatactgctt gttttgtttt ttatgtatgg ttttcacacc gcgaataccg gttcatatat 3309061 ttataacgat ttctaattgg agagagaata actatgaaac ttttacatgc tattcaaaca 3309121 catgcggaaa cttatccgca aaccgatgcc ttccgctctc aaggccagtc gctcacgtat 3309181 caggaattat gggagcagtc tgaccgcgcg gctgccgcga tccaaaaacg catttctggg 3309241 gaaaagaaat ctcctatcct tgtgtacggc cacatggagc cgcacatgat cgtttccttc 3309301 ttgggaagtg tcaaagcggg acatccttat attccggttg acctgtctat tccgtccgaa 3309361 cggattgcga aaattatcga aagctctgga gcagaattgc tgatccatgc agcaggactc 3309421 tcaattgatg cagtcggcca gcagattcag acagtttctg cggaagaact gctggaaaac 3309481 gaaggcggct ctgtcagcca agatcaatgg gtcaaagaac acgaaacgtt ttatatcatt 3309541 tacacttccg ggagcacagg aaatccgaaa ggcgtgcaga tttccgctgc gaaccttcaa 3309601 agcttcacag actggatttg tgcagacttt ccagtcagcg gaggaaaaat atttttaaac 3309661 caagcgccgt tctcatttga tttgtctgtc atggacctat atccgtgcct tcaatcaggc 3309721 gggactttac attgcgtgac aaaggatgct gtgaataagc cgaaagtctt atttgaagag 3309781 ctgaagaagt ccgggctgaa tgtgtggaca tcaacacctt cctttgtgca aatgtgcctg 3309841 atggatccgg gtttttcaca ggatctgctg cctcatgcgg acacatttat gttttgcgga 3309901 gaggttcttc cggtttctgt ggccaaagcg ctgcttgagc gttttccgaa agcgaagatt 3309961 tttaatacgt acggcccgac tgaagcgaca gtggctgtca catcggttga aattacgaat 3310021 gacgtcatca gccgcagcga atcgcttcca gtgggcttcg ccaaaccaga tatgaacatt 3310081 ttcattatgg atgaagaggg acagccgctt cctgagggag aaaaaggaga aatcgtcatt 3310141 gcagggccga gtgtaagccg aggctacctt ggtgagccag agctgacgga aaaagcgttt 3310201 ttctctcatg aaggccagtg ggcataccga actggcgatg ccggctttat tcaagacggt 3310261 cagattttct gccaaggacg tttggatttt cagattaaac ttcacggcta tcgaatggag 3310321 ctggaggaaa tcgagttcca tgtcagacag tcacagtacg ttcgttctgc tgtcgtgatt 3310381 ccttatcagc caaacggaac agttgagtat ctgatcgctg ctattgtgcc tgaggagcat 3310441 gagttcgaga aggaattcca gctgacaagc gctattaaaa aagagcttgc cgcttctctt 3310501 ccggcatata tgatcccgag aaaatttatc tatcaggatc acattcaaat gacggctaac 3310561 ggcaaaattg accgaaaacg cattggcgaa gaggttcttg tatgacgcct tacagctcgt 3310621 ttttattctt tatactgctt ggcattcttc ttctgccgac gatcattctc ggcttaaacg 3310681 gaaaaagatt tcaagcatac aacatgttca tatctatcat tatattggct ttaatttttt 3310741 cgcacgactt acacggggtc atcgcgctgt gcctgtttac aatatggcag gtgctcctga 3310801 tcagcggcta tctggcatac cggcagaaag cgaacagcgg ctttgtcttt tgcggagctg 3310861 ttatcgcgtc tattctgcct ttatttctgt caaaaatatg gccgtttctt tcacacccgc 3310921 agccgcatca tccgccgcat aacctgatca gctttttagg gatttcatat ttaaccttta 3310981 aaggcgttca gctgattatg gaagcaagag acggactgct gaaagaacag ctgccattgc 3311041 accgtctgct gtatttcatc ctgtttttcc cgacgatttc ctccggcccg atcgacagat 3311101 accgccggtt cgtcaaggat gaacagaagg cttggacgaa agaagaatac gccgacctgc 3311161 tgtatacggg aatccataaa atcttcatcg gtttcctgta taaatttatt atcggctacg 3311221 cgatcaatac gtacttcatc atgaatcttc ccgcaatcac gcacaataag attcttggga 3311281 acctgctgta catgtacggc tacagcatgt atttattctt tgatttcgcc ggctacacga 3311341 tgtttgccgt cggggtcagc tacattatgg gcattaaatc accagaaaac tttaataaac 3311401 cgtttatcag taaaaatatt aaagatttct ggaatcgctg gcatatgtct ctgtcatttt 3311461 ggttcagaga ttatgtgttt atgagattcg tattttggat gactaagaaa aagtggatca 3311521 aaaaccgtat ggccgtctca aacatcgggt atttcctgct gtttatgctg atgggggttt 3311581 ggcacgggct cgcgccgcaa tatatcattt acggcctcta tcacgccgtt ctgatgacgt 3311641 gttacaactt tttcgagaag tggaataaga aatataaatg gctgccgtcc aaccgctgga 3311701 caaccattct cgctattgtg atcacattcc atttcgtttg cttcgggttt tatattttct 3311761 caggaaaacc atttcatcac caccattaaa ggagattaga aagctatgga ttttaaacaa 3311821 gaggtattag acgttttagc agaggtttgc caggatgaca tcgtaaagga aaatcctgat 3311881 attgaaattt ttgaagaagg tttgcttgat tcttttggaa cagtagaatt gctgcttgcg 3311941 attgaaaacc gttttgatat tttagtgccg atcactgaat ttgaccggga cgtttggaat 3312001 acacctaaca acattgtaaa tcagctgtct gagttgaaat aatgaaaaag cgttttttcg 3312061 gtccaattat tttggcgttt attctattcg caggcgccat cgcaattcca tcttcatggc 3312121 tgacaggctt catcaccgat aagcgtgtga aagagtcagc aacagccttg aatccgagta 3312181 tgtttcaagg gctatattta caagatcaga tgctcaaaga tccgacatat cttccgattt 3312241 acgggtcttc tgagctttct cggctggacg agttccaccc atctaattat tttcaggtaa 3312301 acaatgaggg attcacgcca taccttgtcg gcaaaggcgg atcccagtca ttgattcatt 3312361 ctttaaactt cgctgcccac atggatcagc tgaagggcaa aaaaatcgta ttcatcgtgt 3312421 ctccgcaatg gtttattaag cgcgggtctg atgaacagca tttcgcgccg aactattctg 3312481 cgctgcaagg gcttgatttg gcatttaacg atcagatcga tcctgaaatt aaaaagaaaa 3312541 tgatgaaacg catgcttcgc tttaaggctg tgcaaaacga tgccattctt tctgagctgt 3312601 acaaagcaat ggtaaacggt cagacgtgga aagtgaacgc gctgaagccg gcggcgaaag 3312661 tgtattacag catgctggaa aagaaagatc tgtattattc aacgacagaa tcatccgggc 3312721 caaagcgcta tatctcgcag tcagtaaagg ataagtcatg gtctgaattg aataaactag 3312781 cggatcaatc gggcaaacgc cactccggtt ctaacgattt tcacatcgac aaccctgtct 3312841 ataaaaagct gaagccgaaa gtgcctaagc tgaaagggaa aaacaaagga agatcgtatg 3312901 cggtgtcacc ggaatatggc gactttgaaa tgatgctcga tatcctgaag gatgcgggcg 3312961 cagagcctat gtttgtcacc attcctgtta acgggaaatg gtacgattac acgggcttcc 3313021 cgaaaaaagg acgcactgac tattacaaaa aggtaaataa acaaatcaga gcgaagggct 3313081 tccaggttgc tgatttctca gggcatgaat atgacccgta tttcatgaaa gacaccattc 3313141 acatcggctg gaaaggctgg gtgtatgtcg ataaagcaat tgacgaattt tataaaaccg 3313201 gaaaagtcac ttcatcctga gcatctcata ggacgcggct gcatatttcc tgctaagatt 3313261 tgtaatagta aaggaatcac agccaactta attaagaggt gttacatcca atgaagatga 3313321 caaataatac ggttttaatc acagggggtt ctgctggcat cgggcttgaa ctggccaagc 3313381 gcctgctgga acttggcaat gaagttatca tttgcggacg cagcgaagca cgtcttgcag 3313441 aagcgaagca gcagctccca aacatccata caaagcaatg tgatgttgca gaccgttcgc 3313501 agcgggaagc attgtatgaa tgggctttaa aggaatatcc gaacttgaat gttctcgtca 3313561 acaacgccgg cattcaaaag gaaattgact ttaaaaaagg gacagaggag ctttttgtgg 3313621 acggtgatga aattgaactt aatttccaag cgcctgtcca tttatccgcc cttttcacac 3313681 ctcatttgat gaagcagccc gaggcggcaa tcgttcaggt cacatccggg cttgcgttta 3313741 acccgttagc tgtttatccg gtgtactgcg caacaaaagc ggcacttcac tcgttctcgc 3313801 ttacgctcag acaccagctc cgcgacacga gcgtggaagt gattgaaatg gcaccgccta 3313861 tggtggacac gggcttaaac caaaaatcac gcgataaaca aggcctgacg taccggggca 3313921 tttcatctga agaatatgtt caatatttct tggacggctt gaaggaaggc aaacaggaga 3313981 ttacaaatga acgtgttgaa ggtcttcggg atgccactcg cgccgattat gacaggttat 3314041 tcgagcaaat gaacacgcag gagaattaat ttctcctgct tttttcatat gaatttctta 3314101 caaatttgag caaacctatt gcgattattt gttgaaggta tacaatagaa tataattatt 3314161 ttcaaataag tttgataata taaacaattt aacagcaggg agattgacca tgactaaaca 3314221 aacaattcgc gttgaattga catcaacaaa aaaaccgaaa ccagacccaa atcagctttc 3314281 gttcggaaga gtgtttacag accacatgtt tgtaatggac tatgccgcag ataaaggttg 3314341 gtacgatcca agaatcattc cttatcaacc cttatcaatg gatccggctg caatggtcta 3314401 tcactacggc caaaccgtgt ttgaagggtt aaaggcttac gtgtcagagg atgaccatgt 3314461 tctgcttttc agaccggaaa aaaatatgga acgcctgaat caatcaaacg accgcctctg 3314521 catcccgcaa attgatgaag aacaggttct tgaaggctta aagcagcttg tcgcaattga 3314581 taaagactgg attccaaatg cggagggcac gtccctttac atccgtccgt tcatcatcgc 3314641 aaccgagcct ttccttggtg ttgcggcatc tcatacgtat aagctcttga tcattctttc 3314701 tccggtcggc tcttattaca aagaaggcat taagccggtc aaaatcgctg ttgaaagtga 3314761 atttgtccgt gcggtaaaag gcggaacagg aaatgccaaa accgcaggaa actatgcttc 3314821 aagcttaaaa gcgcagcagg tagccgaaga gaaaggattt tctcaagtac tctggctgga 3314881 cggcattgag aagaaataca tcgaagaagt cggaagcatg aacatcttct tcaaaatcaa 3314941 cggtgaaatc gtaacaccga tgctgaacgg gagcatcctg gaaggcatta cgcgcaattc 3315001 agtcatcgcc ttgcttaagc attggggcct tcaagtttca gaacgaaaaa ttgcgatcga 3315061 tgaggtcatc caagcccata aagacggcat cctggaagaa gccttcggaa caggtacagc 3315121 agctgttatt tccccagtcg gcgagctgat ctggcaggat gaaacacttt cgatcaacaa 3315181 cggtgaaaca ggagaaatcg caaaaaaact atatgacacg attacaggca ttcaaaaagg 3315241 cgctgtcgca gacgaattcg gatggacgac cgaagtcgca gcgctgactg aaagcaagta 3315301 agaaaaaagc cggcccatta caggccggct ttttttacgc ttcaattttg ttgaaaaact 3315361 gcggcagata cgctttgtgc gcctctagca tttcgtctaa aatctgtttg gccacagtat 3315421 cggacgggac aagcgggtta atcgtcatgg caaggagcgc agtttgatag tcacctgtaa 3315481 ctgccgcttc tgccgcgaca cgttcaaagg atttgatttg ctggacaagg ccgcggacag 3315541 acaccggcaa gtcgccgaca gcaattggct tagggccggt tttcgtcatc acacagttca 3315601 cttcaactgc ggaatcgtct ggaatactcg ctattgcacc attattgatc gtgttcaccg 3315661 gctgaatgtc atgtttatca ttataaatgg agctgattaa gttacatgct gcatcactgt 3315721 agtaagctcc gccccgtttt tccagctgcg gcggtttgat cgcaaggttt ggatctttat 3315781 aaagctcgaa cagctctttt tcgaccttct gtacgacttc agcgcgggtg ccctccgttt 3315841 gtgatgcttc cagttcgtgc tccagcatct cttttgtttt aaaatagtaa cggtgatagc 3315901 cgcaagggat gacattgagc gcttttaaga aatccggttc ccattcggcg cctgagatat 3315961 ttttcatcgt catcgcgttt ttcgggtcgc ccatcgcctc gatgacttgc tccttcacac 3316021 ttacgccgtc caagaaaaca tccagcccga ataccatatg gttcagtccg gcaaattgga 3316081 cttctacgcg gtccacatct acatcaagcg ctttggctac gcccattttg atgccgattg 3316141 gaacattgca aagaccgacg actttcttca ggttggagta gcgaagcaag gcttctgtta 3316201 ccatgccggc agggtttgtg aagttaacaa gccaagcgtt cgggcaaagc tcttctatgt 3316261 cctttgcgat ctcaaggatg accggaattg tgcgcaatcc tttaaacaga cctcccgggc 3316321 cgtttgtttc ctggcctatc actccgtatt ttagcggaat gcgctcatcc tttgctcttg 3316381 cctgcaaaag tccgacgcgg aattgggtcg tgacaaagtc tgcgtctttc agcgcctttc 3316441 tccggtcgag cgtaagatga atgtcaatcg ggacgccagc tttttcaacc atccgtttgg 3316501 cgagtgtgcc gacaatattc agcttttctt cgccctcggg gatatcgaca agccataatt 3316561 cacggacagg cagctcatca taccgtttaa tgaacccctc cactagctcg ggcgtatagc 3316621 ttgaacctcc gccaatcgtt acaatcttca atccttttgt catatgcttg ctcccctttg 3316681 ctcggtgatt ttttcatata actcaatgat ctctgcagcc atatccttca ctgtcattgc 3316741 attcattaaa tgatcctgtg catgaaccat cagaagcgtc atttccgtct tttctccgcc 3316801 cgcttcattt tggatcagct ctgtctgata atgatgggct tttgacaatt cttcagcagc 3316861 gtcttgaagc tttttccgcg cttcttctgc gtcaccgctt ttcgcagcgg caatggcctc 3316921 cattgcggag ctcctaccgt ttcctccgtg aaggatgatt tgaaaaatga tttgttccat 3316981 ttcctcattc acgcgattca cttcctttct ctacagagcc gcttctttgt catctgttgc 3317041 tgcaggcgtt tggaccagct ccagatcgtt ttcttctttc agcttctgct tatcccacat 3317101 tctgaagaat ggatagtaga caacaaagga cacggcaata ttaatggctt gcatgaccgc 3317161 gcctgagact tttcctcctg tcgccaagta gcctgaaaag atcggcggca tggtccacgg 3317221 cactgcgata cccgccggtt tggcgacaag gccggtgctc attccgatgt acgtgagtgt 3317281 cactgtgaca agcggcgtga tgataaacgg aagtaagagc attgggttca tgacgatcgg 3317341 cattccgaat ataatcggtt cgttaatatt gaagatggcc gggccgaccg caagcttccc 3317401 gagctgcttc atttgtttgc ttcgggcgcg caggaacatc gtgacaacca gtgccaatgt 3317461 ggcgccgctt ccgccaatat tgacccagat atcgaaaaat tgctgggtga aaatcttagg 3317521 aagctcctca ccggcttgga atgcgatccg gttggcatcc attgcgccgt accaaatcgg 3317581 tgccatgacg ccgccaacaa tgtttgcacc gtgaaggccg caggcccata aaagcatttt 3317641 gacggcttcg gcgacaaggc ttcctccaag gcttcctccc agaatggaaa gcggagtccc 3317701 caataaaacg cttacaatat tatgaaggct ttcaaacggt gtcgcttcaa caatcagccg 3317761 ggctgcccaa attaggaaga tgacggcaaa gccggggatt aacgcgacaa atgacttgct 3317821 taccgccggc gggacaccgt ccggcatttt gaagactaaa ttgcgctgga taataaggcg 3317881 gtaaatctct gtggacacca ttgcgataat catggcgaca aataagcctt tgcttcccat 3317941 gagcgaaagc ggaatcccgc cgccaaccat gatttctttc gtcgcgccat ccggcataaa 3318001 cggcacttga taaggtgttg ctaataaaaa tgccgcaagg gaaatggctc cggccgacaa 3318061 ggcatcaaca ccgtatttct cggcgagccg gtaggcaatg ccgaacgcgg cgacaagacc 3318121 cataatttca aaggtcgcgt cgactgggta ggccagtttt tcagaccagg agctgccaaa 3318181 cgtttttgcc ataaactcag cgtatcccgg gatcgggagg ttgccaatga tgaggaaaaa 3318241 ggaaccgatg ataatcaggg gcatcgtgag gatgatacca tcacgcagcg cctgcaaatg 3318301 acgctgtccc gcaattcttc ccgctatagg catgaccttt tcttctaaga tctgattgac 3318361 tttattcaca tagcccgccc ctctctatga cacatgtcca agctgttcag ctgatttcag 3318421 cacttccgcc ccattgcacg ttccataatg gacggtatta atgacgtcta ccggaacccc 3318481 ctttgactct cctaattttt tgagctgcgg aagcatgtaa cggacttgcg gaccgagaag 3318541 caatacatcc gctttatcga tatgattttg tacagaatcg cctgaaactg cccaaatggt 3318601 atagtctttt ccctgttcct gcgcactttt ttccatcttg ctcaccagta agctagtaga 3318661 catgcctgct gcacaaacga gtaatatatt catgtaaaag accccctaga gtttgatcaa 3318721 ttttgtaatg tcctgctgtt gctatcatca tattatgaaa tcgctttcat aaacactcag 3318781 ggtttttccg caggcaacgg aaaaaaggta tatacaggct gtcagctcag cattttttgg 3318841 tcaaacacat ccgaaagctc ttgatatgaa cggcatttga tcagctggtt catcgccgcc 3318901 gggtcatcca aaatgctgcc aagcagttta tacatgcttt gtaaatccgc tttgttctcc 3318961 ttttcgacac aaagcagaca gacaaattga actcgctgac tctcccaatc gatcggtttt 3319021 ttgagcgtac aaacggccca aaacgttgtt ttcgtctgcg gaacaagcgg gtgcgggatg 3319081 gcaacaagat tgccaaaaca cgttggcgac atgtcttctc tttcaaaaat ggaatctatg 3319141 atttcttcat cggcaaagcc gcattcgacc actttctgcc ctaaaaattg aatcacttct 3319201 tcttttgagc gcagatcctc ctgaaaaaaa acgagttctt tttttaggta gcgattggct 3319261 ttttcctttt catcactcag aatagattct atttttgtaa agtcagttcc gcctaagatg 3319321 gtgttaacct tcagtactgg tacagggagc tcttttttaa tcggaatggt gctgatgaca 3319381 aaatcaattg attcgtagga catttgatca agactataat actcagccgt tccaagaata 3319441 tcgagccgct tgccgaaatg ggaacgcagt ttttcgcgca gaagctgggc gcttccggct 3319501 cccgatgcgc atacaatgat acagcgtttc ggcgggcttt ctgttttttt tcgttcaatc 3319561 gcggcgccaa agtggagagc caaatatcca atttcgtttt catgaatctc aatacccgtt 3319621 tgttccttta tcacgattcc ggcaatgatc ccggcttcaa aagcgagtgg ataatgttcc 3319681 ttgatcgctg ccagcatcgg atttcgaaga ttcatgccgt atcggttgcg gctgatcgcc 3319741 ggcttcatat gcagtgccaa gccgattttc agctctttgt catgcaggat gccaagcttc 3319801 agttcacgat caacagcttt gatcatggca agtgtcagct gatcggtttc ctcttctatt 3319861 gaaaatgtgt cctctccgca ttgtgattgt gtcattcgtt ttgtgccaag gagatgcatg 3319921 gtgatgtagg ccgtctcgtc tttcggaaac gtaacggaaa gctttgattc cagctctttt 3319981 acgatggctt ctgcagcctg gtactccttt tgatgcagga tatgatccat atctttcggg 3320041 aaaagagaaa catagttttc cgttctgatc cgtttacagg cgatagcgat atggataatg 3320101 aggttattca gtcccatgtt ggacagaggg atgcggtcgt ttttcatttt tttcaagatg 3320161 gcggaacgga tgatctcaat ttcttctttt ggcaaaatat cagccttttc atttaaaaca 3320221 tctatctccg tttctctttc atcaacaatg tactccgcca tgcagtacct catctgcacc 3320281 tcgtccccgc gcagcttgaa gccgtaattc ggacgtgttt ccatgacgat gcggtaaggc 3320341 agcagacgtt tctttacttc ctttaaatcc gtttggagtg tagattttga gataaatagt 3320401 tcttcagcaa gttcatcgag cttgagataa tggtccgcca gcagcagacg tttcataaga 3320461 taggccattc tctcctccgg caataccggc aggccctttt tttgctgaaa ttcatcttgc 3320521 agcagtgttc tgaatacttg ctcgtcatca atgcggagct tgtagccgga gcctcttaca 3320581 gattgtacaa aggcaccgtg gccgcttagc acaccttgaa gttcctttat atcattgcgg 3320641 actgtccgcg tcgttacgtt taattgcgcg gcaaaaaacg aacttgtcac cggggcttca 3320701 gccgccatca gcaagcgcag aatatcacgt agtcgcccat gaagcatgag aaaaacctcc 3320761 taactagtag atgcagggat tcagtgaata ggcagaaagg atgatgaagg gatgcgaaat 3320821 gtatataaat tctataatgg agagaatggc aagtcaatga acatccggag gactagaggg 3320881 aaaactgacc tataaaaaaa cagccgggat cagccggctg ttctagatgc ggacatattc 3320941 ttttgtttag acgccttgcg gtccttcatg atttttcgaa caatcgggta aatgaccggc 3321001 gcccatttga taacggtttt gatcatcttt ttcaaagctc cgattctccc ttcttttttc 3321061 tcaaccattc ccctgattgc ctcttcctta aacatgctaa cgcgacacgt acctgtttcc 3321121 cgtcacccag aaacgccatg gataatcgcg tgcctccccg ctgttgtcaa tgccgatgcg 3321181 cgggccggtt gaaattgctt ccggtgtgta cccgctttcg atgtaaagcg gctgttccgt 3321241 gatccagcgt ccgtagtcat tcatcgtgac gccaagcgct ttcgtcagct ttcctggtcc 3321301 gtttgtccat tccctcggac tcctgcccgg ccttctctcc tccattaaca gctggccttc 3321361 atgcggctca atcgccctga ttaatactgc ttgcgggaca tcctcttccg ccgcaacgac 3321421 attcagcaat gtatgggtgt gcatcacgta tgtatatacc cgcccagctt ctgcaaacat 3321481 gatctcagtc cgcttcgtcc ggcggttgtt aaagctgtgg gccgctctgt ctccagcccc 3321541 catataggcc tctgtttcca caatatagcc tgacgctgtg ccttcgtctg tttcttttac 3321601 aagaaggcag cccagaagcg atggggcaag ctcaagagcg gttttttgat aaaacgtgat 3321661 gggcagcgga tttttttctc tcgtcacgaa tcgacctctc cttttaccga tttttgtaca 3321721 ttgtaccatt cccgaagcag atcaaaaaaa acggctgttt taaaatcttt ccattcaggg 3321781 aatattgtta ccgttcaaaa aaggagggcc aaccattgaa agatgatcat caaaacaagc 3321841 agcaccaatc aaatgcccaa gggagcgagg aagcgttttc tcataagaca tccgggaaaa 3321901 acgagtcaga ggatacctta acgaataggc aggggcatcc tgttactgac aaccagaatg 3321961 tgagaaccgt cgggaataga gggcctacaa cacttgagaa ctatgatttt ctcgaaaaga 3322021 tcagccactt cgaccgggaa cgcatcccag agcgggttgt tcatgccagg ggagcaggtg 3322081 cacatggata ttttgaagcg tacggaagct tcggagacga accgatttca acatacacaa 3322141 gggccaagct ctttcaggaa aaaggcaaga aaacaccggc atttgtccgt ttttcaactg 3322201 tgaatcatgg aaaacactcg cctgaaacat tgagagaccc gcgcggtttt gctgtaaagc 3322261 tatatacaga agacggaaac tgggatttgg tcggaaacaa cctgaaaatc ttttttatcc 3322321 gcgacccgct gaaatttccg gatcttgtac acgcatttca gcctgatcca gtgacaaaca 3322381 tccaggatgg tgaacgtatc ttcgatttca tttctcaatc tcctgaagcg acacacatga 3322441 tcaccttctt gttttcgcct tggggcattc cggccaacta ccggcaaatg cagggttcag 3322501 gcgtacatgc ctataaatgg gtgaatgagg agggcaaggc cgttctcgtg aaataccatt 3322561 ttgaaccgaa gcagggcatc cgcaacctga cacagaagga agcagaagag attcaaggga 3322621 aaaactttaa ccatgccaca caggatctat atgacgcgat tgaaaatggc gattatccag 3322681 agtgggaagt atatgctcaa atcatgagcg atgatgagca tcctgaactg gactttgatc 3322741 ctcttgatcc aacaaaactg tggtataaag acgatttccc atggaaaccg atcggcaaat 3322801 tggttctgaa caaaaatccg gaaaactacc atgcggaagt ggagcaagct tcatttggaa 3322861 cgggagtgct tgtcgacggg cttgattttt cagacgacaa attgctccag gggcgtacgt 3322921 ttgcctactc tgatacgcag cgctaccgtg taggcgcaaa ttacctgcag cttccgatca 3322981 actcgccgaa aaagcatgtc gccaccaacc aggaaggcgg gcaaatgcaa tatcgggtcg 3323041 atagagcaga aggacaaaac ccgcacgtca actacgagcc atccattatg ggcgggctga 3323101 aggaagcgaa gcaagacgga aaagaccata cgccgcatgt cgaaggtgat gtaaagcgtg 3323161 aagcgattga cagaacaaac aacttcggac aggctggaga aacgtaccgg agatttactg 3323221 aatttgagcg gaacgaattg attacgaatt tggtgaatac gctttctacg tgccgaaaag 3323281 aaattcagga tcaaatgatt gagaatttca caaaagctga tcctgactac ggaaaacgcg 3323341 tagcagaagg gctaaaaaag gtctccgaaa acaacagcaa cgggccgatc ggcacaactg 3323401 aaacggaaca ggctgcaaag caggctgaac aggagagtca tccgtctgat ccgtattaac 3323461 aacagcgaac agggcttttt tagaagccct gtttttttat ttttctattg aaacgctttc 3323521 aataattgtg ttgtacttgg aaggaaaggg gtggagagat acgatggaat tacagcagga 3323581 cttgattcct cagaaaaaaa caatcggcgc tttagatcac gccgtttttt tatgcatggt 3323641 attttgtttc tggttttcag gctatattta cgttcctgta ttcagtctgt atttggagga 3323701 tctgcacttt tcatatggcg caatcggcat cattctcggc agctacgggg tcacgcaaat 3323761 ccttctgcga ttcccgctcg gccttttgtc agacatcctg ttttccttgc gcaagcaatt 3323821 gttaattgcc gggttcggct tttccgtcct cagcagcctg ctttttctga tgtttgattc 3323881 tttcttcttc gtgctggccg cccggctttt cgcgggaatc actgcttcta cgtgggtgat 3323941 ggcgaccatt ttatacgcac attatttcaa caatggcaat gcatcaaaag caatgggcat 3324001 catgcagttt tttaccgtca tgcctcagtt tgccagcatt gtgttctgcg ggctcgccgc 3324061 agcccattta gggaggcagg ttcctttttg gatggcgctg gcagcttctg ccgcaggtct 3324121 ggtgatctgc tgctttattc aggatccgtc tgctcctccc gcaaaccgtg gcaccattcg 3324181 tgtcaatcag tacatcaaag atacattgcg gctgccaaag ctgaagcttt tcaccatcct 3324241 gtctatgacg gcccatgccg tattatttat cacagtgttt ggttttacgc cgctttacat 3324301 gaatcagctc ggaatgggcg acgcggagct gctttgggtg atgagcgcct ttttcctccc 3324361 acacgcagcc gccacattaa gctttgtgtt tctgcgcttt acaagccgta tcgcttactc 3324421 cgtgatgctc attagtttcg ctgtcaccgg ggtctgtttg ctatatgttc cttttttagc 3324481 tgcattgttc acggtttgca tcacacacgc ctgtattggg ctggcgctcg gcttcgtttt 3324541 tcctctgctg ctaagccatg tcgtcgaaat cagttctgcc cgtttaaaaa tgtcagtgat 3324601 ggggttttac caatcatttt atgcgctagg catcttcctc gggccccttc ttgccggaaa 3324661 aatcgcacag cttatcgggc ttgcgggagt tttttatgga gccggttctc tggcatttgc 3324721 cgcctttttt gtgatgctcg cgcaaaaacg taacatgatc aattaatagc tttcataccg 3324781 ccggaagcgc cacacagaaa acacggccag aagcatgatg cacagaatgg agaaagtgag 3324841 tgaccatccg aaaaaatctg cccgctctcc atgaagaagg atatgctccg cctgcttgca 3324901 aatctcagcc ggaagccact tcgcaccatc tggaaatagt gaaacagcaa aggaaacggc 3324961 tgctgtgagc ccgatcccgc aagccgcagc tgctccgaca gaccggaata tcgtacttcc 3325021 ggcaaggccg gcggtcacaa taaatatcac ccaaagagcg taaaggccaa ggcttgcggc 3325081 aaagcggctg aatgatgcgt cctcaaacag cagccggacg taatagtaag caagcccgta 3325141 tccagctgca aacgacataa tgccgatcac gctttggatg agccatttac tcacgatata 3325201 atgggctgcc gtcacaggcc gcgacataat cagcgctgtt accccttgat ttctttcatt 3325261 ggctacactg cccatcacgc taaagatgac cagagccatg ccaagcgtgt tgaattgaga 3325321 aagcgtgctg accatcactt cagacccgga gggcatcgta aaactgattt tcatgccgtc 3325381 aggaaggttc cctccatgtg cgatgatttc cggcatataa taaatggtca gcggctgtgt 3325441 cagcccgacg atcatcatcg caatcggcag ccaaatcagc ttgccgcttt tccatccttc 3325501 cagccactcc ttctgcaata gcgccatcat caccttcatg cgtgcaccac ctttagatag 3325561 acgtcttcta gagactccgt tttctgttca aagcgggtga cggtcaatcc ctttcggata 3325621 cagtcactta ataatgaccg gccagcgtgt atatcaggca gctcgaaaac cgcttgggac 3325681 ggattcttat agacaatagc tgagacgtaa ggcttctctt caagccaacc ttccagcttc 3325741 tctttcactg aaagggtaaa aacgttcgtt tgctgctgtt gtttcagctc ctgtaactcg 3325801 cctttccatg aaatctcacc gtttttcata atcaccactt gatcacacac ctgttctgca 3325861 tcgtgcaaaa catgtgtaga aaacagaacg gccatatgct ttttcagctc ccgcatcatg 3325921 tccagcacct cgaaccgtcc tgtcggatca agcgcagaca ccggttcatc caatatcaaa 3325981 aacttcggtt tatggagcag tgcctgtgcc agaccgagtc tttgtttcat gcctcctgaa 3326041 tagcccccga tccttttgtg cgccgcttcg tgcaaaccga caaattccag catctcgccg 3326101 attttctctt ggcattttct cttcgaaagg ccggacagtc tccccgcaaa tgtcaaaaat 3326161 tcatttgcgg tcatccacga ataaaaagca ggatactgcg ggaggtaccc aatcaaacgc 3326221 cgatccagct ttttctctcc taacagcttt atggttccag aggttggcga aagcagtccg 3326281 gccagcattt gcagagtcgt ggttttgccg gctccattag gtcctaatag tgcgacacac 3326341 tcattttcat tcacgtgaaa actgacattc tttacagctt catggtgcct gtacgatttg 3326401 cataatgatt caatagacag catatcggct tacctttgct ttctgccgac ggtgaaaaat 3326461 aaaatcggcc cgataatatt gatacatacg atgattgcag cccacatcca ctttggcccg 3326521 ttcgtccgct cttcttttat acagctgata agggcaaaca ccgccaaagc cagctgtaat 3326581 acaatcagcg gcaaaatcat ttcccaagaa atattcattg cttgatcccc cttttcttcc 3326641 gatccggcct aatgacaaaa aagtaataac aaatcagagg catcggtgct tgaatcaatc 3326701 cgacaatccc ccaaacccat gccatgtgat tacgtttttt cgcatcaata aataaaaaga 3326761 ttccctgcgc caatacgatg agacaagccg caaccgttat gataatttct gtttgtgtca 3326821 tccgcgtttc acctcgcatt cgccgagatg cctttttttc tcagccgcaa tcaaaatcgg 3326881 cagcaccgca agcacacaaa cctgaagcac aataaacaca gcaggagctt gagtgaaagc 3326941 taagattgca gcactcacaa ccatcagcgc gcagaataca aataaaatga tctcttgaag 3327001 aagttttttt ctgtattcag ctttcatttg tgacagctgg tgaagcagtt ctttttgatt 3327061 cggtatagag ggattggctg tttgatcaat ttttttccat tctgacttta aatgatcaga 3327121 aagcttttct ttattcatca tcccactcct ttctgatttg ctggagccct ttatgaactc 3327181 tggactttac agtgccttct ttgatttgaa gcatcacccc gatttcagcg taggtatagc 3327241 cgtagtaatg ccttaataaa accggtgtgc gcagtttagg gtccagcttt gaaaacagat 3327301 cgagcgtttc gctccactct gcccctttcg ccgacacgtc ccacttgatc ttgcggattg 3327361 tttcctccgt aactgtctga ttccgtttcc attctctctt tctctttttc tggtgatcga 3327421 gatagagccg cgatgcaatg gagatcagcc atgtggagaa ttttgaacgg ccctgaaagc 3327481 ttcttaaatg gatgtaccct ttcagaaagg tttcctgaac aagttcctcg ctgagatcgg 3327541 ggtgaaggga aagctttaac aagtatttat ataagaaaga atagtgatag tggaaaaggg 3327601 ctgtaaacgc ctcgtcgttt ccctctttcg cctgctggat cagccgctgt tcttcttgtg 3327661 tatccaatga ccgtgatccc cccttttttg tttttctgcc ttatgagacg acaccggatt 3327721 caaaagcgtt catctttttt acaattcttt tcagccattg acagatcagg cttcccggcc 3327781 gtttggctgc atatccttat ttgtaaaccc ccttatagtc tgttaagcta tgactttatg 3327841 tcgatttcaa aaaaacatcc aatatggagg acgatgcatt gaaagtagaa aggcgaacga 3327901 ttgaatatat tccgaatgaa gaaagacatg gtaaagcgaa agatttattt cccgtatggt 3327961 tcggggctaa tatgcatatc accacgttag tgaccggcac gattcccgtt gcaatgggac 3328021 ttaatctgtt ttggagtgtt gccgctatta tttgcggaac cttaatcggt gccatattta 3328081 tggcttctca ttccgcgcaa ggccctcagc taggcatccc gcaaatgatt caaagccgtg 3328141 cccaattcgg cgtaatcgga gcgattcttc ccctcttctt agtcatgttt atctaccttg 3328201 gtttcttcgc aagcagcacg attctggcgg ccggaacctt aagcagcttt gttcccatcc 3328261 cgggatcatg gagcattata ggcttaagtg ccgtatgttt tttactcacc attttcggcc 3328321 atgatttgat tcacaaaatg caaaaaatcc tttcttggac ctcttttgct gtattttttg 3328381 ctgcaacgat tctcattttt caattgccga ttccggcagg cagctggata cccggagcga 3328441 ttgatctgcc aattttccta gtggcagtca gcgcagttgc gacgtggcag cttgcctacg 3328501 cgccgtatgt tgccgattat tcaagatatc tgccagttaa aacaccggct tcaaaaacat 3328561 tttggtacag ctatgcaggt acatctgtca gctccatctg gatgatgctg ctcggcgcat 3328621 tgctgacaac ctcacttcct gactttacgg caaactcagg cagccagatt gtccaattgt 3328681 tcggtccctt ctcgtttatt atgctgatca ttgtgctatt tgggcaaatg gcaatcaatg 3328741 tttttaacct gtatggggct ttcatgtcca cgacaacaac gctggagccg tttctgaaat 3328801 taaaagtcac gcccaaagtc agaatcatca tgatcctggg tgtcacgctt gtcggcacag 3328861 tcttaagcct actgggacag agcaatttta tggaactgtt tttgaatttt atctttttca 3328921 tcagttattt cttaattccg tggacggcaa tcaatttagt cgattactac ttcgtccgcc 3328981 acggaaagta tcaagtcaaa gccatgttcg acgtaaacgg gccttatgga aaggtcaatt 3329041 ggatcaccac aattgcgttc gttctgtcta tcttgctgga aattccgttt atcaacacaa 3329101 gcttttacat cggaccgctt gccaaaatgt ttggcggcgg agacatcgca tggattatcg 3329161 gcttggccgt gccttctgtg ctttactatg tattaatgaa accgcgtctg aaaaaacggg 3329221 cggggtatca agaaaagctg tcttctctct gaagacagct tttttatcat tcaaatcgtt 3329281 tccacacgcg gggcaggatg tcagatagct catgagcgag caacgtatga gcggagtgct 3329341 cgtccgtcca gagctcggcg cacgcaccat gcaaatagac cgcgtttaat acggcgtgct 3329401 ttggatcttc atggcagcag agcatcccca atatcatgcc cgtcagcgtg tcaccggttc 3329461 cgcccttggc gagcgccccg tttccggttg gattgagcca gcagtctcca tcaggaaacg 3329521 cgatgacggt ttggtttcct tttaacacaa tgacagtctg cagctgagcc gcccattcct 3329581 ttgcatattc cgctcttttt ttctgcaatt cgttcacggg cacccctgtc attcggaaaa 3329641 actcgcccgg gtgcggcgtg aggatgacgg ggccctcccg tttcggatat gtgcgcttcg 3329701 ccagcgctcc ggcatccaaa ataacaggac aatcagccgt aagcacatga tcgactgcct 3329761 gctgtacgct ttccgtttgc ggaaggcccg gtccgatggc aatggcccgg tacgtctctt 3329821 caagctgagc atccgccgcc tttttccagc cgtcacgcca ataggtcgcc tcgggcaaaa 3329881 caggaacaat tagcgggatt acgttttctg atgtaccgat gacaagcttg ccgagaccgc 3329941 tccgcatggc cccaagccct gcaagcagcg ctgctcccgg catgtcgtca cttccagcca 3330001 gcagcaaagc cgtaccgtac gtgcctttat ggctctccgc atctctttca ggaagcgtgg 3330061 cccttacatg ctcttccgtc caaaatggaa cattcatctc tatccctcct ctgctttctt 3330121 ttcctatttt tcctgtccct tttctttttc aaacaaaaaa gacagccttt tagggctgtc 3330181 ttttatttta caggaacatc aaggtgatac aggcggcgat atcgttcgtt tgccgccagc 3330241 agctcctcat gggttccttc catttctgtt ttgccgtttt cgagaaatac gattttatcg 3330301 gctgcttcca ctcccgcgag atggtgtgta atccataaaa tcgtttttcc tttcagcacc 3330361 tcaaacaccg tttccatcaa ttcacgttcg gtaataggat cgaggccgac tgttggctca 3330421 tcgaggatga tgatcggtgt atcctgcagc aaaatcctcg caagtgcgat ccgctggcgc 3330481 tctccaccgg aaaaacggat gccggtttct tgtacagagg tatgatatcc gtcaggcaat 3330541 gactcaatgt agtcatgcag cttgacctgc tttgcggcgc ggcgcacatc ctcgtcgctt 3330601 gcttctccgt ttccgagcct gatgttgttc aaaatgcttg tatcaaacag gtgcggtttt 3330661 tgatttaaca cggccaccgc atccgcaatc tgatccttta acagcgctgt ctccactccg 3330721 tttaacgtca cagaaccgga gtccggtttc aaggcgcctt cgattaatgc aagcgatgtt 3330781 gatttcccag agccgcttcg gccgagcagc gccatttttt ctccttggcg cagcgtaaag 3330841 gaaaagttgt gcagcacttg gctgctgttg tcataagaaa acgtcacatc acgaaaggcc 3330901 aaggtgacat cttgaagatc gagaatttga tcccctgatt cagtttgtga cgcctccggc 3330961 tgaggagcca cattgttcat gcgtctgata gaatcctgat agcccggcac ttcgcctaag 3331021 gcatccgaaa gcggcaaaaa ggcttccgtc aacggaaaca ccactagcac aaaagcggca 3331081 atcatcgttt tagcgagctc gccgtccgct tgctgtcccg ctgtccaaaa cagcatcagc 3331141 aaaataaggc cagcgacaag gcattgcgca gcaaagtccc gccatcttgt aaagcgttgt 3331201 tttttccgtt caagctcaaa ccaatcacgt tcctcttttt cataagcatc aataaaagca 3331261 tgccggcgtc cgctgaacat ccagtcgctg acacccatca cagcatctgt cagacggctg 3331321 tacagcacat tccgtccgct tttcagcttc gcattcttcg ctctcgtcac gagcaaagac 3331381 acaaccggaa acaatacaac aagaacaaac aaatacagcg caagcaatat ggcaaacggc 3331441 caagagaaga agccgagcgc tatcactgac acagcataca ggagcaaggc tgagatcgca 3331501 ggaaaaatcg tttttaagaa agcatcctgc aaatgctcaa tatcctcaga caaaatgccg 3331561 agcatatccc ccgtgcgaaa acgggaacgc agcatcaaag cacccggctc aagcatattg 3331621 taaaggcgga cgcgcatgtc agatacgatt ttcaaaatga tgtgatggcc gacgagccgt 3331681 tccacatatc gcgacacaga gcgcgcaatc ccaaaggtgc gcacagcgac aatcggcaca 3331741 taaatgagca gaatgttttc cggccttgtc gccgctttag aaatcaaaaa acctgaggtg 3331801 aacatgagaa aagcagcaga aaaaatcgtc accgcaccca aaaagataac cagaacgaac 3331861 aggcgggcat tttgcttgat atacggcaaa atccattctt ctttcttcat gctctttccc 3331921 ccagttgtgc cttcacgagt ttggtataca caccgttttt ctccagcagt tcattgtgag 3331981 tcccaatttc cgcaaccctg cccccgtcaa gcacgataat ttcgtccata tcgagcatcc 3332041 agtgaaggcg gtgagtcgcg agaaagacga gcttatcctc aaataaatcc agcatcgttt 3332101 cttttatttc atattctgtt tcgatatcaa gatgggcggt cggctcatcc agcagcagga 3332161 tcggacggtt tcccaaaaag gcgcgggcca gcgcgacacg ctgtgcctgg ccgccgctga 3332221 gcgcccggcc gccttccccg atccgcccct ctaatccgtc aggaaggttg ttcaccagct 3332281 ccgtcagtcc cgctgaggca gcagcacgtg ttgtatcctc tgccgaagcg cttggatggt 3332341 agaagcgaat gttgttgcca agcgtatcat caaaaatgta cggatgctgg ggaatgtaaa 3332401 gaaggttctt ctgccagctg ccgtcctgca aatgggaccg gcttgtacca ttaacctcaa 3332461 tcatcccgcc atccggctct aaaaatccgc cgagaatatc aattaatgtt gattttccgg 3332521 cgccgcttgc accgataatg ccgatttttt tcttgccttt gaatgagaga tgaatatcag 3332581 acaccgaacg gccgactgac acgcctgaca gcttcagctc atcctgatcg gaccaagctt 3332641 cgagctgaag cggcgtctct tctttaaaac caggctgcga caaaatctct tgaatggttt 3332701 ttcctgcttc ctggccgttc agcgttgcat gataatcatt ccccacttcc cgcaccggca 3332761 aaaaatactc aggcgccaga ataagcgccg ttaaagcagg gccaagcaaa atatcgccgt 3332821 caatgaggcg caggcccaga aatactgcga ctgtcgccac cgacagcatc gtgaaaaaat 3332881 cgagggcgaa tgatgacaaa aacgccaccc ggagtgtgct catcgttgcc ttgcgatacc 3332941 gctcactcac atagaaaata tttttgctgt gtgacttgct caaacctagg aaacgcaatg 3333001 tctccagccc gcgaagagaa tcaacaaaat gattggaaag tctctgatag gatttccact 3333061 gacgatccgc ttttctctgc gcgacaaggc cgaggagaat cataaagatg atcagaatcg 3333121 gcatagcagc gactaaaatg atggctgatg tccgatcctg aaaaaacaca taaatgacaa 3333181 ctgccgcagg cacaatcgcc atgctgacca ttttcggcag aaacagctcc aggtagcggc 3333241 ggaactggct gatgccttcc atcgccagcg tcaccatttg ccccgtcccc tctttctttg 3333301 caaagcgggg gcctaatcgg aacagctgat caagaaaact tttcctcaaa tctgctcctg 3333361 tccgggcggc gtattgatag acgattttct gtcgcgccac cgtcatcccg tgccgggcga 3333421 taaaagcgat gaggaaaaag ccgatcaccg gtaaaaggga ggtaatgccc ttcccgttga 3333481 acagtccggt tacggcctca ctcagccact ctgcctgcat aataatggcg gctgtctgaa 3333541 tcaacgttaa acaagtaatc aaggtgagaa tccgcttcat tcctttatat cgaaacaggt 3333601 cttttcccat taataagtca taggctcctt atggctgacg cgcttccgga agacataata 3333661 gctccagatc tggctgccga tgacgaacgg caatagcgtt aatgctgcaa ttgacatgac 3333721 tttaagcgaa taatctccag aagaagcgtt agctactgtt aaatcgtatg cgctatgaag 3333781 cgagctgacc attacacgag ggaataggga aataaagatc attcccacgg tcagcgccag 3333841 accagcgcct gtcatcccaa atgtccagcc gtcttttttc ttacgaataa atacagccgc 3333901 gagcataaag cagatgacaa tcaaaacagc gagcggaatg gtaatctcgc cgcggcgtgt 3333961 aaacatgtct gtctgatacg cagaaagggc cgcgaaggca agaaccgcta caaaaacaac 3334021 acccattatc ttttgcgcca ttttccgggc gcggttttgc aaatcaccaa tcgtacgcag 3334081 cgtgataaac attaatccat gctggaagca aagaagcgtt accgtcacac cgccaagtat 3334141 agaatataca ttgatataat cagatacatg tgcgtgaatg ttcatgtcgg catcaatcgg 3334201 catcccgcgg aataatgtcg tgaacagcac accaagcaca aacggaggaa ttagactgcc 3334261 gaaaaaaacg acccagtccc aaacctttac ccattttaaa tgatccacct tgccgcggaa 3334321 ctcaaacgcg accccgcggc ccattaacgc aagcagcact atgacaaacg gaatgtaata 3334381 accgctcagc atcgttgcat accagtttgg gaatgccgcg aaaatggcgc ctgcgccagt 3334441 caaaagccac acttcattcg cgtcccagaa cggcccgatc gtgttgatca gcactctgcg 3334501 ttctaattca ttatggccaa gaaaacgggt cgccatgccg accccgaaat caaagccttc 3334561 caaaaagaag aatcctacaa acaatacagc aacgagtata aaccaaagat catgaagaga 3334621 tgccatggta tacctcctga ctaaatggat ctgttgatac aggcacatca tgatgattat 3334681 catgctccgc acctttttta atctcacgga taaacaagaa gacaagcagt gcaccaagaa 3334741 tcatgtacat cacaccgaat gcgatgattg agaataacaa ggaacccgct gttacgttag 3334801 gcgacacaga ttgagcggtt gtcattaacc ccataaccgt ccaaggctga cgtccgattt 3334861 ctgtcataat ccagcccgcg gagtttgcaa gaaacgggaa ggaaatcaac gcgatcatga 3334921 tgcgcaaata ccatttgctg ttttcaagct ttttacggcg gtttaaccaa aggccgccta 3334981 acgcagcaag aatcatgaca acacctgctc ctaccatgat gcggaagctc cagaatgtcg 3335041 ttttcactgg cggaatgtag tcgccttttc cgtatatttt ttcgtactca gcctgaaggg 3335101 ttttcatccc tttgacactt ccgctgaatt tctgataagc caagtagctc aaggcataag 3335161 gaactttgat ttcatttgag cttttttcat tttttgtatc gatcgtcgca aaagcggtcc 3335221 aagcagcagg gtcaccgctg tcttcccata ggccttcact ggcagccatt ttcatcggct 3335281 gtgattccat caagtgctca gcctgcatgt gtccgctaag gccgacgcca agaccggcac 3335341 aaagaccgac gatcattgcg agtttaaaag attgcttaaa gaacggcact tcttttttct 3335401 tcagcagttt aaaagcactc actccggcaa taaagaaagc tccagtggca agcgcaccga 3335461 aaataacgtg cgggaattca acccaaagct gagggtttgt aatcaacgcg ccaaaatcat 3335521 tcatttccgc gcggccgttt ttgatcgtaa agccgaccgg ctcctgcata aaggagtttg 3335581 ctgttaaaat ccagaaagat gacatgatcg ttccgaatga tacgagccat atgcagagcg 3335641 cgtgaatttt cttcggcagg cggtcccagc caaaaatcca taatccgata aaaatagatt 3335701 ccatgaaaaa cgccaataat gcttcaatcg caagcggagc gccaaataca tctccgacaa 3335761 aacgggagta atctgaccag ttcagtccaa actggaattc ttgcaaaatc cccgttacaa 3335821 caccgactgc gaaatttatt aagaataagt gtccccaaaa ctttgccatt ttgagataca 3335881 gctcattttt ctttacaaga taaagagtct ccatcaacgc aaccataaac acaagcccga 3335941 tagacatcgg cacaaacaag aagtgaaaca acgttgttga tgcaaattgt atgcgggcta 3336001 ataccaattc actcatgctt tctcctccat ttccggttaa aactgttaat ttgctcacta 3336061 cttcacaaat agaaccgaga ctttgatcag taattcacaa aatagacgaa aaaaatattg 3336121 ctcaatattt cacaaatgtg tcaaaaagtc atccaatatg atgcaagatt gccagactga 3336181 ccaaatgaca caatctctga ctggttcata ttaagtactt tacaacgatt catttcaaaa 3336241 ataaagccta aaatacctaa aaagtcccgc actatgtgac ggatttttgt ctattttgtt 3336301 gcttatttat gtcggctgct aggataaatg accctttatt atcgtacatc aacacatcgt 3336361 tccttgcgaa caaaatgctt gcccccgccc cagcactcga gtctcagcat tccgtcttaa 3336421 accgatttta gtcagaatgc ctcttttcat ttgaaccggt aagaggagaa aagttgaata 3336481 gtaaattttt aatatattaa taatttcaat tttttagtat acttaacata gtgaacaatt 3336541 tcactgcatc aagaataggg gaggtttttc aatgggagag cttcaaacac acatgcaatt 3336601 gcaaacggat acaattcacg aaggggttcg aaaagagaat tggtttgcga aagccatgaa 3336661 tataaaagta ggcatcatac cgcttcctgt gtatgccttg ctgtttatat taatcactgt 3336721 ttttgttatg catcacgatg taaaaagtga cattttgaca tccattgccg tcatggcgtt 3336781 tttcgggttt acctttgccc aaatcggcaa atcgataccg attgttcgtt ctatcggcgg 3336841 cccggccatc ctagctactt ttattccgtc cgctgtcgtg tactatcacc tgctgcctaa 3336901 tgatatcgtc aaatccacca cagaatttac agaaaactca aactttctat atttgtttat 3336961 cgccggtatt gtcgtcggaa gcattctcgg catgaaaaga gaaacactcg taaaagcatt 3337021 catgaaaatc tttattccgc ttattgtcgg ttctgtcaca gccgctattg tcggactggc 3337081 tgtcgggaca ttgctcggac tcggatttca gcataccctg ctgtacattg tcattccgat 3337141 catggctgga ggagtcggag aaggcgctat cccgctgtcc atcggatatt ctgacatcat 3337201 gcccatttct caaggggaag cgtttgcact tgttctgcca tcgattatgc tgggcagctt 3337261 gtgcgcgatt attctagcgg gattgctgaa ccgaatcgga aagaaaaaac cggaatggac 3337321 aggcaacggc aaagtggacc gctccgaaga agagtcccct gcgctggagg aatctcaaag 3337381 cggacagcaa atgttcaacc tttctttatt tgcgtcaggc ggtatccttg ctgtttcttt 3337441 atacttagtc ggcatgctcg ctcacgattt tttcggtttt ccggcacccg ttgccatgct 3337501 gttactggct gttctaatca agctgttcag attggtgcct gcctcaattg aaaatggcgc 3337561 gtttggagtg tcccgcttct tttcaacagc tgtgacctac ccgcttctct ttgcgattgg 3337621 ggtatccatg acgccgtggg acaagcttgt cgccgctttt aacctcagca atattatcac 3337681 gattctgtct gtcgttgtga ccatgatggc cgttggcttc ttcactggaa aatggctgaa 3337741 catgtatccg attgaaaccg ccattattaa tgcatgccat tctgggcaag gcggcacggg 3337801 tgacgttgcc attttaagcg ccgctgaaag gcttgagcta atgcctttcg cccaggtgtc 3337861 tacccgcatc gggggcgcga ttacagtatc cttaacctta ttgctgctgc accagtttta 3337921 ttgatccccg caagcaagtt cttcgtcaaa cgaaagagct tgcttttttg catgtccatg 3337981 tttttgcaag ttcccatccc atgctatagt aatagttgga aatactagat agaaaggaat 3338041 ctggcatgcc tatgggaact catctatttc tctttatgct tctcgggctg ggattttatt 3338101 tgatatcagc cctagctgca aaactcattc cggccataga cttctggatt gatattgttc 3338161 tatgggtcgg cgctgcggct tacatcttct ctcatctctc attcatggac ggcattgtct 3338221 cactcgcgac aatgttctac tgctattgga ccgcaatgga tctcattgtt tcagagcgtg 3338281 tggaaaaacc ttcgggagac tggcaggaaa tcgagcttgc caaaaacaaa acacgcctcc 3338341 tgtcagacat tacgctgacc gccattgtgt ttgcaggggc tgtcattttt ttcatctatg 3338401 gacctgacac aagccctctc aaatatgtga tccttctcgg aatgatctcc ggcggagggg 3338461 cacttgtgaa gcgaatactg aatgttttta gcgtaaaggt tttttattca gcagccttag 3338521 aaaaattgca tatcagctca cactatgaaa cccgtacata cccgctttcc gatttgaaga 3338581 acattcagct tgaatcaaca gcagatctct taaagctcca tccgcttctg acgatgtatt 3338641 catcccgttt agatttgaca acaagctttc agcaagtcat taaactgtct cttcccggcg 3338701 aaacactgtt tctgacggtg aaggaaccgc aaaaatggaa aacaattctt caggaataca 3338761 cagatgcaga aaacaatgtg gacaatgtga tttctgtttt gccgttttat catcgaaaaa 3338821 atgtgaagcg gctgctcggt aagctttatt ttgccgccag cgtaaaaggg gtatccgctt 3338881 acgccttatt ggtgctcgcg ttatacgcat tacacgcctc tccatgggtc atggctgttg 3338941 ccgtaatcct atattgggta ttcaacatgt atatgtcaga ccgtgtgttg cgggcggcga 3339001 tggacgccaa gtcttgtcat catccgcatg tacaggccgc ggccgataag attttcagat 3339061 cggccggcat ttcccatgtc cgcatatacg aaacggagag tgatgattac aacggaatgg 3339121 cagtaggcat gaatgtcggg aggtcaatgg tcatcctgac aagcgccaca ctaacacttc 3339181 cacagcgtgt cattgaaggc attctggccc atgaggcgat tcatatcaaa aaacgtgacg 3339241 ttctgtcatc acagcttttg cgttttctat atcttggagc tgtcgtgggg attttcctct 3339301 tgtttgagca gcatatcacc catcccgagg cccacaaaat tgcgctttgg gctttcatta 3339361 tggcaatcat tatcctattc cagctctatc aatccttttg ttcacaatgg atggaggtgc 3339421 gtgctgacaa ccttggcgca tcattgctgg acggcggtta caaacaaatg gctgaagcct 3339481 tgagaatctt ggcggttcgg caagatgagg atatacagaa acaaagtgcc tatagctctg 3339541 aagcaggtga agacgagctt caaattgatt ctctcacccg tgataaaagc tggtttttca 3339601 gattgattga ttttcagttc gctcctcatc ctcctatgta ttggcgtgtc ggcactttat 3339661 tgtcaaacaa aggacatggg gtgctaaagc gctggctcag agaccgactg aaagaatcga 3339721 tcactttgaa atgaaaccgg tcagcgtttc atccgtataa cagatatggt gaaaaaaggg 3339781 agtgacgcga agtgattgtg atcatcttat tgtttatatc tattattgtt tttctttcag 3339841 tcattcagcc gcagccctcg aaaaacaaaa gccgccagca ggcggacagc gggtatttcg 3339901 gttattcaga tcatagctca caccatgatg gatgcagcag tgacggaggt ttcagcgatt 3339961 ccggctgtgg cggcggaggg ggcggcgatt aaacgccgcc tttttttatt tcattgattc 3340021 gatgtacgca ccaaaagccg agcctgacat gcctggggac acgcgcacac gatggagggc 3340081 atacattccc tggtctctcg aagccgcgcc cggttctgtc gtcacgccca tttgatagcc 3340141 tgttttttca gcggccttca gcgtctcctc attgtagcgc cctaccggat agctgatgat 3340201 ggtggtttgc tgatgaaaca tgttgtcgaa cagctttttc gaatcagcca tctcactttg 3340261 ctgctgttga ggcgttaatc cgttcagctc aaggtggtca atcgtatggc tttcaatcga 3340321 tatgccgtgc tgtgccattt ccttcatttg ttcctctgtc agatggtgct tatgtccgat 3340381 cgatttgccg atcataaaaa tcgttgcctt catcccgtac tttttcagca ccggatacgc 3340441 atcttgataa ttgtcggtgt acccgtcatc aaatgtgatc agcacgcact tctcactcgg 3340501 ttttttatcc tgcgtcagca tgagagatgc ctctttcggc gttaatgtct gatagccgtt 3340561 atcatgaagc cacttcatat gcgcctcgaa ttctttcttt ggcacacgga ggctgtttcc 3340621 tgaagaaatg ctgtggtaca tcaaaatcgg cagctttgcc ggtttctctg ttttgatcca 3340681 tgcggatgta tcgtcttctt ttttctgaac ttgtactgcc tttttttccg gtttcttttg 3340741 ttccgctttt ggcatcggct gctctgcatt cgcctcttga tcagcacaag ccgcaagagc 3340801 caaacagctg cccaaaagaa agatgcttaa aaacaatcgt ttcatcgttc tcctgctttc 3340861 tgtctatttc ttcctccttt ttcatcggtt tgattctgag attttcaata gcaaaaaacc 3340921 ggacatgtct ccatgtccgg tttttttgat cttatcggat tctcacttct gtctcactgt 3340981 caaagaaatg gcctttattc atatcaaatg caaccgtcag ctcatcgccc gattgaatat 3341041 cgaggcgggc gtcgatccgc gcaataaagt cttggttgtc tatctgcgaa taaatcataa 3341101 tttcagaacc gagcagctct gcaacattaa ttttcgcctt aatcgaagag ttcttatatg 3341161 attccacgac aatcaattca tcatgtatat cctcaggacg gatgccgaag atgacctctt 3341221 tgccgatgta gcctttttca cgcagcactt tcatttttcc ttccgggacg gttaatgccg 3341281 cagaaccgat tttgattaag ccatccgtga gctttccttt gaaaaaattc atcgccggtg 3341341 atccgataaa cccgccgaca aagacgtttt cagggaattc atatacatcc ttcggcgtcc 3341401 cgatctgctg aattttccca tctttcatga ctacaatccg tgtcgccatt gtcagcgctt 3341461 ctgtctggtc atgcgtcaca taaatcgttg tagtctgcaa tctctggtgg agcttaatga 3341521 tttccgcccg catttgcacc ctcagcttcg cgtccaggtt tgacaaaggc tcatccatca 3341581 ggaacacctt tgcatcccgc acgattgccc ggcccagcgc aacccgctgt ctctgtccgc 3341641 ctgacagcgc tttcggttta cggtgcaaat attcctcaag cccgagaatt ttagcggctt 3341701 cttcgactct ttttttgatt tcaggcttcg gcattttccg aagcttgagc ccgaacgcga 3341761 tattatcgta gaccgtcata tgcggataaa gcgcgtagtt ctgaaatacc atcgcgatat 3341821 ccctgtcctt tggcgctaca tcattgaccc gttttccttc aatataaaaa tcacctttcg 3341881 aaatttcttc aagtcctgcg accattcgca gcgtcgttga tttcccgcag ccggacgggc 3341941 cgacgaatac gataaattcc ttatcggcaa tatgaaggtt aaagtcatca accgccggtt 3342001 ccttctgatc ataaaattta taaatgtgct ccatccgcaa ttcagccatc taacatcccc 3342061 ctttgttatt gtaaacgctt tcttatattg agtgtaacag caattccctc tcgctaaaat 3342121 gggcagcgtt cataaaatca cccagccatt tttcgtgcat atttccaatt tattctgaac 3342181 tttcattttg caggcagata aaataggcaa gaagcgcgcc tttgtacgat ttgatatcta 3342241 tccctgaccg ctcaataaat ttatcaatcc gatattgcag gctgttgcga tgcagatgca 3342301 gctttttcgc tgttaatgtg acgtttgagt tgttttcaat aaacagctta atggtcttcc 3342361 ttagctcaga ttcacttcca aataaaagct cagcttcttc agagagcagt gtttccagtt 3342421 tttctttttc tgtttctaat aatagaaaag gaaagatcat ctcaaaggtc acactctgca 3342481 cctgaggcag ccgtttttca gcaaacagga aatacgcctg ttcacgagcg taatgttttc 3342541 gcagacactc atccggctcg taaaatcttc cggcgtaaaa acggacactg aagtagaaat 3342601 cactttcaag aaccttagcg agcgattcca gttcgtcctt ctccgccgcc gcttcacttt 3342661 cctgctcgac aatcacacct ctgtcctcat ggatccacac aatcacaaaa gacaccggcc 3342721 aaaaatggcg aaccgcttcc gtaaaggacg tcctttctat tttgccgaat aaatgaaagt 3342781 gaacaaatct cgtccgtttc tttatatacg ccggcaattc ccctctggaa aaaaggaacg 3342841 aaaaccactt gttttcctca ggtgatttca tagacagttg attgccctca tccgcaggcg 3342901 tcaaaaatga ctgcagcacc aatacttctt tttcactgat ctctgttttc ggaatggaga 3342961 tatatctctg attgctctca tcaaaaaaac atagacagcc ttcccttatg caaagctcct 3343021 cagacacaat cgaaccggga taaatagcca gcagcgattt catagagtct cctctcttat 3343081 gtaaggatct gtatattcag tataaggcga aacacacatg ttctccacta aaaaagagta 3343141 tatccggtat agatagacga gaaactgaaa gggaaacctc attcgtttac atattggctt 3343201 cagcggaaat agaagaagac atgcaggacc aaaggagggt catcttatga gtttcgaaac 3343261 gttaaacaaa agttttatca acggaaaatg gactggggga gaaagcggac gtacggagga 3343321 cattttgaat ccgtatgacc agtctgtgat cacaacagca tctttggcaa cgggcaaaca 3343381 gcttgaggat gcgtttgaca ttgcacagaa agcccaaaaa gagtgggcca agagcacgac 3343441 ggaagaccga aaagccgtgc tgcaaaaagc gcgcggctat ttacacgaaa accgtgatga 3343501 catcattatg atgatcgccc gcgaaactgg cggaacgatc attaaatcaa caatcgagct 3343561 ggaacaaacg attgcgattt tagatgaagc catgacgtat actggtgaat taggcggcgt 3343621 caaagaggtg ccatccgaca ttgaagggaa aaccaataag atttaccgcc ttccgctagg 3343681 tgtcatttca tcgatttctc catttaattt cccaatgaat ctatccatga gatccattgc 3343741 gcccgcaatt gcgctgggta acagcgttgt tcacaagcct gatatccaaa ctgctatttc 3343801 cggcgggacc atcattgcga aagcgtttga acacgccggt cttcctgccg gtgtccttaa 3343861 cgtcatgctg acggatgtaa aggaaatcgg ggacggcatg ctcaccaatc caatcccgag 3343921 attaatcagc tttacagggt caacagcagt cgggcgccac atcggtgaaa tcgccggtcg 3343981 cgccttcaaa cgaatggcac ttgagctcgg cggcaacaat ccatttgccg ttctttcaga 3344041 tgcggatgtc gatcgtgctg tggatgccgc gattttcgga aaatttattc accagggaca 3344101 aatctgtatg attatcaaca ggatcatcgt tcatcaagat gtatacgatg agtttgtaga 3344161 aaaattcacc gcccgtgtca aacagcttcc gtacggcgat caaaccgatc cgaaaaccgt 3344221 tgtcggcccg ctgatcaacg agcgccaaat cgagaaagcg ctggagatca ttgagcaggc 3344281 aaagacagac ggcattgagc ttgcggttga aggaaaacgc gtcggaaacg tgctgacgcc 3344341 gtacgtcttt gtcggtgcgg acaacaacag caaaattgcc caaacggagc tgtttgcccc 3344401 aatcgcaacc attattaaag ctggcagcga ccaggaagcg attgacatgg caaatgatac 3344461 tgaatacggc ctcagctctg cggttttcac ttctgattta gaaaaaggcg aaaagttcgc 3344521 cctgcaaatt gacagcggca tgacccatgt caacgaccag tccgtcaatg attcgccgaa 3344581 tattgccttt ggcggaaaca aagcaagcgg tgtcggccgt ttcggcaatc cgtgggtcgt 3344641 cgaggaattt accgtgacga aatggatttc gatacagaag caataccgca aatatccgtt 3344701 ctaaatgaaa aaatccctct gtttcaagta cagagggatt tttctttatt tagatatatc 3344761 cacaaaccct tcgccaaaca catcgcgtac gtcatgtacg atcacaaacg cttttttgtc 3344821 gcagcttcta atgatttttt tcagcataga cagctcctgt ttgttaatga cgatatacaa 3344881 aatctctttt gactggcccg tataatttcc cttccctgat aaaatcgtca cgccccgatc 3344941 catcaaggta tttacctgct ctgcaatctc actcttattt tctgaaatga ccgtaatggc 3345001 ttttttcgta ttcaaacctt caataatgaa gtccatcact ttggtaccga tatacagcat 3345061 cacgatcgta aacatcattt tttctgcacc aataataaaa taagagctaa atactacgat 3345121 taaatcaaaa aacaagagtg catagctgat attccagtct aaatatttat tagcaattct 3345181 ggccagaatc gcggaaccgg ccgtcgtccc gccgacccgg ataatcatgc cgatcccgac 3345241 tccggcaaat acacctgcga aaatcgtatt aatgatcaat tcatcagacg gaatgctcca 3345301 cccatgtgtc agatgaagaa aaagcgaatt tgccgcaacc gcaatgatcg tataaaccgt 3345361 tgtttttcca tcaagaaact tgtagccgat taaaagcaaa aacgcattta agataaagtt 3345421 cgtgacacca ggagaccatt gaaacagata atacaaaatc agcgtaatcc cagtgactcc 3345481 gccttcccca agatcattgg gaatcgcaaa taaattaacc gcaagcgcga agaaaaaagc 3345541 gccaatcaca agcataagta catccagcat tctctttttc atcacgaaaa cactcctttt 3345601 cattgttctg ttctagcaaa taaaaaaacc caggagaacg ctctcgaaaa agagcagaaa 3345661 ctcctgggct tttatcccac cgtgtcataa cagccaagct gctatgtgtt ttctctcggt 3345721 cacagtccaa tttgcattgc ggaaccctag aaaaccactg tttttatcat atccttttca 3345781 ctttccaata ttagcattat aagggacggt tcgaattggt tcaaggggta tttgcggagt 3345841 tttcatcaga taagctggaa aaaaatacga tttatctatt aaaaaagaac agatataacc 3345901 gataagaaaa aaagcatata ttttacaagc gaatgtaact ataaatgata ataattataa 3345961 gaaattcata attttatatt gactaagaga aataatatag gcattatagt acatatgttt 3346021 cgtacatttt attacatagg aggaaatata atggcaggaa aactagtacc ctgtaaagct 3346081 tgcggtcaag aaattgcaaa gggtgtaaaa aaatgtccta actgcggtaa ggatcaacgt 3346141 aactttttta tgcgacataa aatcattacg tttattctcg cagttgttgt catcattatt 3346201 atcggtaata tgattggcgg cggaggcggc tcagaagcca cttccaaaac atcaagcagc 3346261 agcaaagcag aaactgaaaa aacatacaat atcggtgata ccgtaaaaac tgaaaaaact 3346321 gaagtgacgg ttacgaaggt agaggacaga gatactgtcg gtactcaata tgttgaaaag 3346381 aaagcatctg agggaggtac aattgtagct gttcaatata caattaaaaa cgtatctaaa 3346441 aagccgatta gctctttttc aattccaact gttaaattag ttgatgctga tggtacttct 3346501 tatgattctg atattgatgc ttctgtaaac tatgcaactg agacaaaagt tgataactct 3346561 aaaattttga gtgatctaaa tcctaatatt aaagtaacag gtgtaaaagc atttgaagtt 3346621 gacaaggaag cttatgcaaa aggcacttgg aaactaaaat tcagtaatga tgttattgtg 3346681 aaaatcaaat aacagctaac aagggtgcct gtttaggcac ccttgttctt taaaaaaggc 3346741 cttctcaatt gagaaggcct ccattcttat tccgcactct tatacccatt cacattagaa 3346801 gactgccatc tccaggaatc agcacacatt tcctcaaggc cgcgtttcgc ttcccagcct 3346861 agttctcgct tggctttcgc aggatctgca aagcatgtgg cgatgtctcc cggacggcgg 3346921 tccgcaaaac ggtatggaac ctctttccct gacacttttt caaaggcttt gaccatttcc 3346981 agcacgctgt agcctgtgcc tgttccaagg ttgtatgcat cggctcctgt agagttcaat 3347041 actttttcca gcgccttgac gtggccttct gcgagatcaa cgacgtgaat ataatcgcgt 3347101 acgcctgtcc cgtcttttgt cggatagtca tttccgaata cgcttaattg ctcgagcttc 3347161 ccgactgcta cctgtgccac atacggcata aggttatttg ggattccgtt cgggtcttca 3347221 ccgatccgtc cgcttggatg cgcgccgaac gggttaaagt aacgaagcag cgcaacgctc 3347281 cactcattgt cggctgtatg caaatcacgc aatatttgtt caagcatgag cttcgtctgc 3347341 ccataaggat ttgtcgcgcc taatggaaag tcttccgtaa tcggcgatgt ttccggaacg 3347401 ccgtatactg tcgcagatga actgaatacg attttcttga cgccgtattt ctccatggcc 3347461 tcgcataaaa taaacgttcc tgtcaaattg ttatgataat atttgagggg aatcgccaca 3347521 gattcgccga ctgcttttaa ccctgcaaaa tgaatcacag cttcgatttc attttcagca 3347581 aaaacggaat ctaccgcttc ccggtccaat aaatccgctt cgtagaacgt taaatctttt 3347641 cctgtaatct ccttgacacg gttcagcgct tcagctgaac tgttggacag attatcaaga 3347701 acaacaatct cgtagccgct gttcaatagt tcaacacatg tgtggctgcc aatgtaaccg 3347761 gcaccgccag taacaagtat tgccatgatg taaaccctcc taaaaaatga cctgttttca 3347821 ttatatagtg tttagaaccg gtccacatcc atttttaaga agtttaatcg tttattaata 3347881 gttttttcat attttttagc ttaaaccctt gccagcaatt cgatagaggt ttcagcaaga 3347941 atgtgctctt tcatttcttg atagagctca ttcaagtaaa agcccggctg aagattcagc 3348001 tcagcatcta aagcatagac cgtcaatgta tacgcatgat ccttgtcagg cggtgtcggc 3348061 ccgcaatact ggtgaatcac ctttggatcg ttgcttcccg caagcggtga agcaaagctg 3348121 ttttgccctt gtatcatcaa gtcctgtctt tcctcactcg catgttcagg aagctctccg 3348181 atgtaagccg gaatattagc cgctgtccag tgaatccagc tgaatccgca tacgggaatg 3348241 gcgtcatgat cgatgaaagt aagtgcgagc gtctttgctc cggacgggat gtcatcaaaa 3348301 tgaattggaa aggatacaaa tgggtttcct tctctcttat atttttcatc cgcgtatttt 3348361 gaatacttgt catgtaaata tggatttgct tctacgtata tgttcatatg aatccctctc 3348421 tctattttct cgttctatag gtatactaaa cgaatcgatg tataatcagt gataaacaaa 3348481 tacgcatgta aacgtaacaa tttgttatgg ataacttgca gtgaaggaga tatttcatgg 3348541 atttaaaatg gctgcaaacc tttattgccg cagcggaatc agagagcttc agggaggcgg 3348601 ctgagcatct gtatctcaca cagcctgccg tttctcagca tatgaggaaa ttggaagatg 3348661 aactggacat gaggttgttt ttgcatagcg gaagacgagt cgtactgact gacgaaggca 3348721 ggctcttttt gccttatgcc aaagaaatga tccatgttta ccaagctgga aagcagaaag 3348781 tcagtcaatg gaaacagggg tacagccgat cactcacgct ggccgtacac ccctacattg 3348841 cgtcctatat cttgcctcgc tttctgccag cctatatcca aaaacatccg catgtcgagc 3348901 tttcaactca tgtggctgga tctgacgcta ttaaacaagc ggtggaacac aatgaagctg 3348961 atattggttt gtcgcggaaa gacccgaaca ccaacactct ttattatcag catatatgcg 3349021 aaggtacgct ttgtctggcg gctcctttcc aagaaagcag accggatgct gcatccgtct 3349081 taacccgcta tcggctgcta acgcatgatc atccgtcata tggggatgcc tttttagata 3349141 acatccgatc acattacccg tatcttcaaa tgatggctgt cgggcagacg gatacggctg 3349201 tccacatgat gaaagcggga atgggggcat ctttcctccc tacctacatt atcaaacagg 3349261 aagaagccga aaaaaagctg atggctgtca gcacgcctgc acatctagaa ttgcctgcgt 3349321 cccaaacgtt tatgatgtgg aaaagaaaca gcgaagacat tcagcatttt cacgccatgt 3349381 tacatgactt tatgcagcgc gaacaagtat agagctgaaa aatcaatctg ccggttgacg 3349441 tttttctttc ctattttcgc tatgcttaat gcagaaagga tttgatgaca tggcgatgag 3349501 cccttatatt tttattgtat tgattcttat tattttatcg atgtatcgag aaagaacggt 3349561 aaagcccggg aagttgctga tcattccact gttgctctta tggggcgtat ctgcatcgtt 3349621 tcagccggcg tattttcatt ccgtattaca tgtggcgatc agcggcattt tattactgat 3349681 cgggctggcc tgcgggtttg gcattgggaa gatggtaaat gtacggattc acccggaaac 3349741 cggaaaggtc acttcacgcg gctcacttgg gagtgttatc ctcattctag tgatactttc 3349801 tttgcgcatg gccgcgagaa catggctgcc tgagagcaac gagatgttta ttgccattat 3349861 tcattctatg ttcttcgttc ccctcggcac catcacagcc cgcaacatca tgctttacaa 3349921 agcatacaga cgactgaccg ctggcaaagt atccattcaa taaccgaaag aaggaccagc 3349981 atgaacggac aaactccggc tcggcactac tacaagaagc ttgtgccgag ccttattctc 3350041 attttgaatt gcatacaatt tttatctcat ccaactaagg ctgatcccat tttgttagca 3350101 tttgtatttg cggtatactt agcattcatt tggatcattc cctatgtggc atccactgct 3350161 gttagtttga gcatattcat cggactctgg ctcctgaccg atttcttttg ggctgtttcc 3350221 ggccaagagc agggtgccgc ctattttttg attgtatttt taatgatata tgccgccttt 3350281 agactccctt cacggctatc cttgatcttc acagcatgtt taattggagg caacatatta 3350341 ctcctatcct cacaaggggg aagcttgaat accatcatca gcaacatctc gatcatgctc 3350401 ggtctgtacg tcctcttctc ctccatgcgt ttcagacgag aagcgagaag ggaggctgaa 3350461 cggaatcatg ctgaattggc aaaaatgcat gtgcagctgg agcatgctca taaagaactc 3350521 cagaaagcgc atgcagagct gcaggaggct tctgttcttt cattaaggta cgcggtcctt 3350581 gaggaacgta caagaattgc ccgcgacatt catgacagca tcggtcacga gctgacttct 3350641 gtgattgttc agcttcaatc ccttccctat atccttaaaa gcagcaagga ggattcagaa 3350701 aaagtcattc aaaatgtact gagtgtcgcc agggagtgtc ttcaagaagt gcggtctgtt 3350761 gttcaccaaa tgggccgtag tgaatcgatg gtggggctta ccgctttgcg ggggctcatt 3350821 catcaagtgg aggaacggag cggcttgcac gtttctttag atactgccgg actgtcagaa 3350881 gagtcttggc ctccaaacgt gagcgaaacg atctaccgca tcttgcagga agcgctgacc 3350941 aatatcattc gtcacgctga cgcttctcat gcggcggccg tcatttctaa tgacaagtcc 3351001 catctctatg tcacaatcac cgacgacgga caattcaccg gcagccttac ttatggattt 3351061 ggcctgacag gaatgaaaga gcgcgcagaa aaagcaggcg gttcccttac tttcagtgcc 3351121 gtacagccga gcggcctgaa aattgagctg tcattgccgc tcatgacaac gaataaggag 3351181 caaaaagatg aacaaagata aaatacgcgt agcgcttgcc gatgatcagc cgcttgtgcg 3351241 tgaaggcttc cgctacgtca tcaacgcaca gacggatatg acggtttctg gcgaggccgg 3351301 cgacggtcac gatattatag cactcgcaaa acaaacaaaa cccgatgtca tcctcatgga 3351361 tgtccagatg ccgcgttgct caggcatcga agcggcgaaa gacattatgt ccgcacttcc 3351421 aaatacaaag atagtcattt taaccacctt tgacacggaa gaatacgtat ttgaaggcat 3351481 ccgtgcgggc gcagtcggct atctgctgaa ggatacactt cctgaggagt tgatagatgc 3351541 gattcgcgct gcggccagag gcgaggcgat tttccgtaca gtcacagctg ctaaaatcat 3351601 cagtgagaca tttcgggcga aacagcaaac tcatgccgaa gaactggcag agccgttcac 3351661 caaaagagag cttgaggttc ttcagcaaat ggcctacgga ctgagaaatg aggatattgc 3351721 tgaaaagctt ttcgtcagtg aaagcactgt gaaaacccac gtgcaccgca tcctgcaaaa 3351781 atgcaatgcc caagaccgga cacaggcagt cgtttttgcc attcgaaacg gtattgtgca 3351841 atagaaatct ctcatcccgc catgctaaaa taagacaaag gagatgattg gaaatgaaag 3351901 aagaaatcat tgaacggttt actacatatg taaaagtcga tacacagtcc gatgaatccg 3351961 ttgacacttg tccttccaca cccggccaat tgacattagg aaacatgcta gttgatgaat 3352021 tgaagtccat cggcatgcag gatgcagcca ttgatgaaaa cggctatgtc atggcaactc 3352081 ttccctccaa tactgaaaaa gacgtgccga caatcggctt tctcgctcac gtcgacaccg 3352141 ctacagactt taccggcaaa aatgtgaatc cgcaaatcat cgaaagctat gatggaaaag 3352201 acatcgttct taacgaacag ctgcaggtca ccctgtcacc tgatcaattc cctgagctgt 3352261 ccggctataa gggccataca ctcatcacca cagacggcac cacccttctc ggcgcagaca 3352321 ataaggccgg tatcgctgaa atcatgacag ccatggatta cctcatcaaa caccctgaaa 3352381 tcaagcacgg cacaatcaga gtcgccttta cgcctgatga agaaatcgga agagggccgc 3352441 acaaatttga tgtgaaacgg ttcaatgcat cctttgccta cacggttgac ggcgggccgc 3352501 tcggcgagct tgaatatgaa agcttcaatg ccgctgccgc aaaaattacg attaaaggca 3352561 acaacgtaca tcccggaaca gctaaaggaa aaatgatcaa ctctgcgaaa atcgcgatga 3352621 agctgaacag cctgctgccg gcagacgaag cgcctgaata tacggaaggt tatgaaggct 3352681 tctaccacct gctgtcgatt caaggagacg tagaggaaac aaagctccac tacattatca 3352741 gagactttga caaagagaat ttccaaaaca gaaaagaaac aatgaagcgt gccgttgaag 3352801 aacttcaaaa cgaatacggg caagaccgga ttctgctgga tatgaacgac caatactaca 3352861 acatgagaga gaaaattgaa cctgtcatcg aaatcgtcaa cattgccaag caagcgatgg 3352921 aaaacctcgg catcgaaccg aagatttccc ccatccgcgg cggaaccgac ggatcacagc 3352981 tgtcctacat ggggcttccg acgccaaaca tctttacagg cggggaaaac ttccacggca 3353041 aatttgaata catctcagtt gacaacatgg tcaaagccgt aaatgtcatc gttgagattg 3353101 caaagcagtt tgaagcgcaa gcataacgcc aaaagccagt ccaaaaaagg actggctttt 3353161 ttgtgtgaaa atgaaacatt ttaaacacgt cctccgtaaa acaagtatca acaaatgagg 3353221 aggaaaaaca atgacaaaac atgcaatcgc tgccaagagt ctcttgaaaa aatggatcat 3353281 ttccaggccg cttaacatga aaaagaaatc cagcccattt caaaaaatca gaaaaatgtt 3353341 caaacgcttc ttcaaataaa acatcaaatc ccctaaatac aatccgtatt cacccgtacc 3353401 gcccaaatgc tccgtaattt gggttttttg tgttcaattc cgcaaaatag ggtataaacc 3353461 aaacaagcaa gaaaacagca cccaaaaaca ggtaattcga attacgtaaa cttaggttaa 3353521 aagttatata aaggaattta ttttatcgtc gatagtaact atagaaccaa tcatcaacaa 3353581 gagcaaacag cgtaattcaa gactattttc aggtcatcag gtaatactgt tttagaggga 3353641 cagtttcttg ttatttattg atttagaatt ttttgaatac tttttggcat tttatccgta 3353701 caatagagag taccaaaact ttttttggga ggtatgtaat atgatcctat ttattatcat 3353761 cgcattatgc ggctatcttc ttttttcttt cagcaaggac aatcgccgca aaccgcaaaa 3353821 gacaagccct ctgccagcag ccgcacctca tcacaacaac ctaatcgacc ttgacgccat 3353881 ccgccaaaaa cgccggatgc atctttccta attctatatt tcaaacgaaa aggctgctga 3353941 atcacgcagc cttttaaaat tgttttgatt tagagcctga aaccttttcg ccacctatcc 3354001 gtaatttcat acaaggcaaa cccaaaggag acttcagcaa tgatcgagtt atttatgaaa 3354061 caaaaaatgt tctcatttaa agatgcattt cacatttatg accgggatga acaagaaaca 3354121 ttcaaggtgg aggggcgttt tttctcgtta ggagactcat tacaaatgac agactcatct 3354181 gggaaaacgc tcgtttccat agaacaaaaa ctaatgtctt tattgccgcg ctatgagatt 3354241 tcaattggcg ggaaaacagt ttgtgaggta acgaagaaag taacgttttc caaaccgaaa 3354301 tttgtgattt ccgggcttaa ctgggaaata gatggtgatt tatggaggga tgaattccaa 3354361 ctgacggacg gggaaaatgt ccggatgtca gtgagcaaaa agtggctcag ttggggtgat 3354421 tcctatcact tgcagattgc atacgaggaa gatgttctga tttgcactgc catcgctatc 3354481 gtgcttgata tggttttata taacgatgaa gatgaaagta ttttctaaaa agcattgaca 3354541 attgatccaa aagtaataat attaagataa ttgaaatctg aatatgaagt tgtaccttat 3354601 caagagaggt ggagggactg gccctatgat acccggcaac cgctgtttca aacagaatgg 3354661 tgctaaatcc ttaagaacat tgcgttcttg cagatgaggc ggagatttga tcgttcaagc 3354721 tcttccttac acaaaggaag agctttttac atgcttaata tttcagaaaa gaggcgaata 3354781 acatggctca acaaacgaat gttgcaggac aaaaaacaga aaaacaacgc aaagcacctt 3354841 tccgcgccga tcatgtcggc agcttgcttc gttccgttcc ggtaaaggaa gcccggcaaa 3354901 aaaaagcggc tggtgagatg acagcggaac agcttcgtga tatcgaaaat caagagatca 3354961 cccgcatcgt ggaaaaacaa aaagaaatcg gtctcgatgt ggtaacagac ggggaattcc 3355021 ggcgttcctg gtggcattat gacttcctgg aagggcttga cggtgtggaa ccgttcatcc 3355081 cggctgaggg gattcagttc cataacacaa aaacgaaagc gcgcagcatc aaagtgacgg 3355141 gaaaactcga ttttacgagc cacccagcgc tcggtgatta tcaattttta catgagattg 3355201 ccggtaacgc gacgccaaaa ttgaccattc ccagtccaaa tatgctgttt tttggcgaaa 3355261 aggcggataa agggatttat gacgatcaag aggaatactt tcatgatatg gcccaagcgt 3355321 acaaaaaagc aatcaaagcc ttctatgatg ctggctgccg ttatctccag cttgatgata 3355381 cgtcatggtc tctcttcttt gaggacaaag gcagagaggt tgtccgggcg ctcggcggtg 3355441 atccagaaac attgccagcc atatttgcca aaacaattaa cgatgccgtc gcagaccggc 3355501 ctgacgattt aacgatcaca atgcacattt gccgcggcaa cttccgctca acctgggcgg 3355561 catcaggagg gtacgacgct gtagcggaaa cgattttgga cggcttaaac cttgacggcc 3355621 ttttcttgga atacgatgat gaccgctccg gaaactttga tccgctccgt tttgtgaagc 3355681 gcaaggatct gcaaattgtg ctcggcttga tcacatcgaa atacggcgag cttgaaaatc 3355741 ctgaggatgt gaaacgccgt atcaatgaag ccgcgcgttt tgtcagcttg gaccagctat 3355801 gcctgagccc gcagtgcggt ttcgcctcta cagaagaagg caaccttctg acagaggagc 3355861 agcaatgggc aaagctgcgc catgtcatcg acattgccaa cgatgtgtgg agataatcta 3355921 tcattgacag aaatagaaaa tgtgtgaata atagatacta tcagaaaatt taataaaaag 3355981 gttttcctta tcaagagagg tggagggact ggccctgcga tacccggcaa ccgctgttta 3356041 acagaatggt gctaaatcct ttagagcaat gattgctctt gaagataagg ttgagattgt 3356101 cacgcaagct cttccttatc caaaggaaga gcttttttat atttgaatgg aaagaaggaa 3356161 tggacaacat gtcacaacaa acaacacccg cagaacaaaa atcacttcaa agaaaaaaac 3356221 cgccgtttcg cgcggatcaa gtcggaagcc tgctaagatc tgagcccgtc aaaaaagcgc 3356281 ggctgcaaaa agcggccggc gaaatgaccg ctgagcagct tcgccaaatt gaaaacgacg 3356341 aaatcatccg cattgtggaa aaacagaagg aaaccggcct gaacgtcgtg acagacggtg 3356401 aattccgcag agcatggtgg cactttgatt tcctggaaaa cttagatggc gttgagccgt 3356461 ttactcctga gcaaggcatt caattccata acgtacagac aaaagcacgc ggcattaaag 3356521 tcacaggcga tatcgacttt tcaactcacc caatgcttga agattactca tttctccata 3356581 gcattgccgg tgacgcgacg ccaaagatga cgattccaag tccgaatatg ctgtttttcc 3356641 gcggaaaact ggaaaaggat gaatacaaaa acgattatca acttttccag cacgatgtat 3356701 ccaaagcata taaaaaagcg attcaagcgt tttatgacag aggctgccgc tacctccagc 3356761 ttgatgatac agcgtgggcc gttttcttat cagaaaaagg cttaaaacaa atcgaagcgt 3356821 tcggaacaac gcctgacgag cttcgccagc tgtttgcgaa atccattaac gacgcgattg 3356881 cagaccgccc ggatgacttg acggtaacca tgcatatttg ccgcggcaac ttccagtcca 3356941 cttggacagc ggaaggcggc tatgacgcag cagccgaaac catttttgac ggcttgaatc 3357001 ttgacggact tttcttagag tatgatgatt cacgctcagg cggatttgag ccgctccgtt 3357061 acgtaaaacg gtctgatctt cagcttgttc ttggcttagt gacatctaaa ttcggtgagc 3357121 ttgaaaatcc ggatgacgtg aaacgccgta tcgaagaagc gtcccgttat gtaagcttag 3357181 accagctttg cctcagccct caatgcggat tcgcttcaac tgaggaaggc aacaagctga 3357241 ctgaagaaca gcaatgggcg aagctccgcc atgtggttga gatcgctaat gatgtttgga 3357301 aataagcaaa gaaaaaaaca cacttgattc cctagcggag caagtgtgtt ttttatgtca 3357361 ttgtgcggtg tagcccccat caaggacgac agcctgccca gtgacgccct tcgccttctc 3357421 gcttgccaaa aacacggcat aatccgcaat ttccttgacg gaaagcagtc gcttttgcgg 3357481 cacaagcgga aaaatgactt gttcaagtac agagtcgtaa gggacatttc tagttttcga 3357541 tagatcgcta agctgattgc gtacaagctg ggtatcgaca taacccggac agagcgcatt 3357601 gactgttatg ccgtggggcg cgccttccag cgcccctact tttgtgagtc caatgacgcc 3357661 gtgcttggcg ctattataag cggatttccc tgcaaagccc actaatccat taacagacgc 3357721 aatattaatg attctgccaa actgctgttt tttcatgatc ggaaaaacat gcttcattgc 3357781 aataaaggga gccgtcagca tgaccttgat cagctgttca aaggtgtctg tcggaaactc 3357841 ttcaatcgga gcgacgtgct gaataccggc attgttcacc agaatatcca agcggccgta 3357901 ttgtttttgg atgacgttca ccgtatcagc aacttgcgct tcctttgtca catcatacgg 3357961 aatggccgcc gcgtcaaagc cttcttctgc aagcttggag gctgcttttt cacatgcttc 3358021 cggacggagg tctgaaacga tgacgctggc accttcccgg gcgaattctc ttgcgatttc 3358081 gaatccgatt ccgccggcag cccctgtcac caaagcgact tgttttctca tgtcaaacac 3358141 cttcccatta agaattgagt acagactggc ttacagcgaa atcagcttct gttttttcat 3358201 aaacctcttc aattgtgaca ccatcctgaa gctccgtcag tgtcatgcgg ccgttcacaa 3358261 aatcaaatac agccaaatcc gtaatcagcc tgtgtacgac tttctggcct gtcagcggaa 3358321 gggagcatgt ttttttcacc tttgattcac catgcttatt gacgtgctcc atgatgacaa 3358381 cgattcgttt cgccccgttg acgagatcca tggcgccgcc catccctttt accattttgc 3358441 ccgggatcat ccaattggcc aaatccccct gctccgaaac ctccattccg ccgagaatag 3358501 ctaaatcgat atgcccgcct cttatcatcg cgaatgactc agcgctgtca aaataagagg 3358561 cgcctgtcac ttcagtgatc gtttcctttc ccgcattgat caaatccgcg tcttccgttc 3358621 cttccagagg ataggggcca attccgagca agccgttttc cgactgaagc atgacgtgaa 3358681 cgccatcggg tatctcattt gcgacaagcg tcggcattcc aatcccgaga ttcacattca 3358741 tgccgtcctt gatttcttgt acagcccgtt tgaccattcg ttttctcgct tccttcactt 3358801 ggcctcaccc tttcccgatg cttgctgaac tgttcgtttt tcaatccgtt tttcttggct 3358861 cgcgccaagc acgacatgct gtacgtaaat tcccggcgta tggatgtgat ctggatcgag 3358921 ctctcctgct tccacgattt cttccgcctc ggcaatcgtg atcttgcctg ccatggcggc 3358981 aatgggattg aaatttctcg ccgttttcct aaaaatcaaa ttgcccatgg tgtccgcttt 3359041 ccacgctttg acgatcgcca catcgccggt aatgcctcgc tccagcacat aagtccggcc 3359101 gccgaatgtt ttatgttctt ttccctcggc tatggaggtg ccgacgcctg tcgccgtata 3359161 aaatcccggt atgcctgcac cgcctgcacg aattctctca gcgagcgttc cttggggaac 3359221 aagctctacc tcaagctctc cgcttaaaaa ctgccgctca aaaattttat tttcaccgac 3359281 ataggaagcg atcattttct tgatttgctt gttagccaga agcaaaccaa gcccccagtc 3359341 atcgactccg cagttattgc tgacaacggt taaatccttt actccctgat ctcttataga 3359401 caaaatgagc tgttcaggga tgccgcacag cccaaaccct cccgcgatca gcgtatcccc 3359461 atcatgaatc agtttcgcag cttccttgct tgatgacagc acttttccca tattgatgcc 3359521 cctttcgttt tcttctacac tagaccagtc aggctgtaaa tcgcgatcac agcaaatacg 3359581 gcagccgttt taatgagcgt gatcgcaaaa atatcgcgat aggattgccg gtgggtcaaa 3359641 cccgtcacgg ccagaagcgt gataacggcg ccattatgcg gcagtgtatc catcccgcct 3359701 gatgccattg aaatgacccg atgcatcacc tctggcggaa tattgtaagc ctgaatcgcc 3359761 tgtaagtatt gttctgacat cgcgcttaac gcaatgccca ttcctcccga agccgagccg 3359821 gtgattcccg ccagcgcagt tgtcgtaacg gcgccattta caagcggatc ggtaaaagta 3359881 tgtgaaattc cgctgctcag cttatgaaac cccggcagcg cggcgataat gccgccgaac 3359941 ccgtactcag cacccgtatt catagatgcc agcaaggcgc cgccaattcc ttcattcagc 3360001 ccttccttca attgggcaaa cacacttctc caatcaaata atatcgttgt gatgatgcca 3360061 atcactaaag caatctccac cgaccaaata gcagccgctg aagaaatatc aagcctgccg 3360121 aactccttta atcctatgga agaaaaatca aatccattcg gataccactt tggcaggtaa 3360181 atggtgaaat atttattcac tgcaccgacg agaataagcg ggacaaaggc aagcgcgtgc 3360241 cgaatcgggc ttttgtccgg ttcagccgcg gactcaatcg attcaggagc aggagcattc 3360301 tgcgaatcaa aaccgccata gccttcgcca gatgcctgcg ctttcttccg ccttgattcc 3360361 aaatagagca tcccagctgc cagcacaatc actgcgccca tcaaacccag ccaaggggcg 3360421 gcataaatgt ctgttttgaa aaacgacgtc gggatgacat tttggatttg cggcgttccc 3360481 ggaagtgcgt ccatcgtaaa cgtaaaagct cctaaagcaa tcgtacccgg gatgaggcgt 3360541 tttggtatgt ttgcttcttg gaacatgttt ttcgcaaaag gatatacagc aaatacgaca 3360601 acaaacaggc tgacaccgct gtacgtcaag acagcaccca tcagcacaat ggcaagtatc 3360661 gctctttttg ccccgacaag ccggacaatt gttttcgcga ttgatgccgc aagcccggcc 3360721 atttcaacga cctttccaaa aatagcaccg agcaaaaaca ctgggaaata cagcttaata 3360781 aaacccgcca tcttctccat aaaaattgat gaaaaaaaag gaagcacatg gcttggatct 3360841 gtcagcagca ccgcgaataa cgcgcaaatc ggcgcaaaca atatgacaga aaatccccga 3360901 tacgccgtaa acatcagcaa acctaacgcc aatagaatga tgatcagttc cacacacaca 3360961 tcccccgttt ccgcgaacta gaaagcgttt acaaaaacct gtccgcatcg gctgtttccg 3361021 tcccctttcc atatgtacga gaagcgtggg ccaactattc cgattaaaaa aggaaagctc 3361081 cttttttcgg agctttcctc taccattcat ttcattccta ttaggatatc aacatcaacc 3361141 gtaatatcgg ctgatttcat ctctttcagc aggctgactc gatctttcgg cgccgaccag 3361201 gcaagcggcg tcatcttgag aagccagtgg atcgcctgct ggtcaagcgt tttaacatag 3361261 cgcagcctga caggacggct gtgtgctgca tttgctgtaa aacgctcaac tgctgccgta 3361321 ttggaatacg tgcgccttgg tgaatcagta tataaaaatt gccttaattc tattaaatag 3361381 tcgcttcgcg gcactacttt tatgagcatg ccatcattct tcagcagtct atgaaactct 3361441 gcataattgg acggcgaaaa aatagacaga acaacatcaa attggcgatc atgaaaagga 3361501 gcacgcgcca catcggcaac cgcccacatc agatctttga atgccttaga agcttttaag 3361561 atcccgtcct tcgaaagatc tatgccggtt cctatcgctg ctttccctgc ataatcaaac 3361621 ccgcaaagcg cattcaaatg agaaccctca ccgcaaccgc tgtccaagat ggtgaatgcc 3361681 tcatgaccag atttgggatg actgatgagc tctgcaatcg catcatggag cgggtcaaaa 3361741 aaaccacatt ctccaatcag cctgctcctc gcttcaaaaa gctcggcacc gtaactggtt 3361801 ttgaccggct tcgtcagaaa gttcacgtag ccgtgccgag atagatcaaa tgtatgtcct 3361861 cgttctgtac aaatcaagct tttccctgat gccgcatcca tagaagaatc gcagagcggg 3361921 catcgaaaca tgctgaaatc aactgttcgc ttcatgataa aaaacacccc attcattcat 3361981 ttttagataa atgaaaaagg catagacaaa taaacctagg cctatctcaa aaattggcca 3362041 ggtctggcag tttgtctaca cctgtcatta tctataacga atgaattgga taatcatgaa 3362101 aaaaactccc tttctgctgt atgggtttcc ccgtttccat catacaacaa atatccagga 3362161 gctggaacct tatagtgaag aaaaatcagt actgacatgc tggtatcccg ccaacatcat 3362221 atcagcatag caatccagca tgtttttcct ttattttctc attttagaat ataaatttta 3362281 ttattgtgaa aatagttaaa aaggttgatt ttcaaaaagt gaaaggataa aatactgcta 3362341 tcatcttaga aaaagacatt cttgtatatg atcagtaata tggtctgatt gtttctacct 3362401 agtaaccgta aaaaactaga ctacaagaaa gtttgaataa atttgaacga gttgaaaagg 3362461 acaagttctt ttctgtttgc tcttattttt cacactttct gcacttccag aatttgtgaa 3362521 ggataagagc tttttttgtt tccataataa ccctcatagg agttgctatc atgtactttt 3362581 tactaaacct tgtcggtctc attgtgatta tggcagttgt attcctatgt tctccgcaga 3362641 aaaagaaaat caagtggcgc ccgatcatta cgttaattgt tctggaattg ctgattactt 3362701 ggtttatgct gggaacaaaa gtcggaagct gggccatcgg taaaatcggt gatttcttca 3362761 cttggctgat tgcttgcgcc agtgacggta tcgcgtttgc ctttccgtca gtgatggcga 3362821 atgaaacagt agactttttc tttagtgcgc ttcttccaat tatctttatc gtcacattct 3362881 ttgatatttt aacgtatttc ggcattttgc cttggctgat tgataaaatc ggatgggtga 3362941 tttcaaaggc ttcccgcttg ccgaaattag aaagcttttt ctctattcaa atgatgttcc 3363001 ttggaaatac cgaagcactt gcggtcatcc gccagcagct tacggtttta agcaacaacc 3363061 gcctgctcac attcggttta atgagcatga gcagcatcag cggctccatt atcggatctt 3363121 atctttcaat ggtgcctgcg acatacgtgt ttacagccat tcctttgaac tgcttaaacg 3363181 cgctgattat cgcaaacctg ctgaatcctg ttcacgtgcc ggaggatgaa gatatcatct 3363241 atacaccgcc taaagaagag aagaaagact ttttctctac gatttctaac agtatgcttg 3363301 tcggcatgaa catggttatc gttattttgg caatggtgat cggatatgtc gcattaacgt 3363361 cagcagttaa tggcattctt ggcgttttcg tacatggcct gaccatccag acaatttttg 3363421 cttatctgtt cagtccgttc gcattcctgc ttggactgcc agtgcacgat gcgatgtatg 3363481 ttgctcagct gatgggcatg aaattagcaa cgaacgagtt tgttgcgatg cttgacttga 3363541 aaaacaatct caaatccctt ccgcctcaca ccgttgcggt ggcgacgaca ttcctgacgt 3363601 cctttgcaaa cttcagtact gtcggcatga tttacggcac gtacaattcg atccttgacg 3363661 gagaaaagtc aacggtcatc gggagaaacg tgtggaaact gctcgtcagc ggaattgcgg 3363721 tatctttatt aagtgctgcg attgtcggcc tgtttgtgtg gtagaaacat tgagccatat 3363781 cccttttcgg atatggctct tttcattatt gataaataga ggctggcacc tgcacatccc 3363841 ggattcccgc tgcataaggc cccaagtcat actggccgaa gacgatggcg atcccgtttg 3363901 ccgtaaagta aaacattgtg tctctgttta gggttatatc ctctttcttt acatcagaga 3363961 aaaacagcac atcgtgtttt ttgatatagc tatataggta atctctcgtt ttgctgactt 3364021 ttgttttggt gttcagaatc tgatccagcg tcacccgctt ttgtgctttc aagtcatagt 3364081 tgaaggactg gacagacgtt agaccgtggg cgccccctga atagatataa ttgagtgttt 3364141 gaatgctgag cttgcctgcc gcattgtatt tgacgctgaa ggatgtttga tattcccgtt 3364201 ttaaagccct gctgttcgcc tgcttttttg tttttcaggt attcctgata cgattgttca 3364261 tgtaggcttt cagctcttga ttgattttct tttcaaacgc ggcattcccg acgtgatgca 3364321 cttgtggata cgttaactcc ttgatctttt tgtacgtatg ggtgctgaca gtcggtgttt 3364381 tcgcttgaac tgcttttaaa gatggggccg catatgcaaa tacagaaaaa agcaagactg 3364441 caatgcccgc ggctttcagc atgttattcc atttcataca atctactcct ttgatgtcgt 3364501 tgtttatcat tcccttattt aagcaataca cacttttata gactgattaa atcgaaagaa 3364561 gtttctaggt ctaacagcat gatttttcca ataaaaaaag agacacagga tgtctctttt 3364621 tttactgttt gcgcccagaa atcgcttcat gaagggcttg tgccaaatct gtatttccga 3364681 acatctctaa taccgcaatg acagtctggt ccggaatgtg ctctgcttcg tgttttggca 3364741 cgaccagatc gtccatggtt tttttcaagc tttcattcag cttttgctgc ggatacgctt 3364801 tggcgtacag ctccatcgga tcaagatcat ggttcacgca ccactgggca aacaccaaaa 3364861 tcatcatatt ttcatcgcgt tcgtaagctt cagtgagctg tttttcgttc atttgtcatg 3364921 ctccttatga aaagtatctt ccttaaagat acaggagccg atcaaattcg tctatcccaa 3364981 tggcgatgag cagcaaccgc atcgataaat gccttgctga aagcggtgta gtcaggttca 3365041 tctttagccg ttacgatgcc tagcccctct gttgtcccga cagaggattg aagaaggtca 3365101 attccttcat ttgccgcacc gatcgccttg tagtgattgt aagcttctct gataaacgcc 3365161 atcgcttgtt tgttgtcttt taactccagt cctcctgcgg catagacggc atcatacaga 3365221 acagaatcaa ccgtcaggaa cgtgccgctg gcctcaagct gctgtccgct gccgcttgtc 3365281 atatacccca gattttgact gatgatatcc actgtgattc cttcttgctt taaggcttcc 3365341 agtactgttt gcagctcttt ttcatgaaat ccgtttccgg cgagtacagc gacttttctt 3365401 gttgacgcgg ttttcactgt acgggcttgg cttaacgcag gcgaagtaag aatttcttta 3365461 gatgctttac gcttcgcggg cgccgccacg cctactcctt tggcgatttc ttctgctaaa 3365521 tctgcatcga cattgctgaa gacatcaacg acctgccgct gtacgtcttt gcttttgacc 3365581 ttcccgacct cgaagcagaa agcagaaatg atgtgctgtt tctccacagg agacatgctg 3365641 ttccagaaaa gcttcgcctg tgagtaataa tcgttgaagc tgtcgcttcg ctggcggatt 3365701 tttttgccct cgactttttc ctgatagtgg acgtagccgc cttcttcagc tgtcgcaggc 3365761 gacggatcat tgttttgcag tgagttttta tgataagcga caggtccctt attgatcgtc 3365821 atccggtgat agccgtcgta ttggttgtta tggaatggac agaccggccg gttaatcgga 3365881 atctcatgga agttcgggcc gccaagacgg atgagctgtg tatccgtata agagaaaagc 3365941 cgcccctgca atagcgggtc attggtaaaa tcgatgcccg gcacgacatt tcccgggtgg 3366001 aatgcgactt gttctgtttc cgcaaacaca ttatcctgat tgcggttcag cgtcattttt 3366061 ccaatgatct tcaccggcac aagctcttcc ggccacagct tagttgggtc aagaatatca 3366121 aaatcaaact tgaattcatc ttcctcatca atcatctgca cgccgagctc gtattcaacc 3366181 ttgccgccgt tttcaattgt ttcccacagg tcacggcggt ggaaatctgg atctttcccg 3366241 gcaatttttt gcgcttcatc ccatacgaga gaatgcacgc cgagcaccgg cttccagtga 3366301 aatttcacga aacgtgcctt tccttgttca ttgacaaaac ggaacgtgtg aacgccgaag 3366361 ccttccatca ttctgtagct gcgcgggatg cctctgtcag acatcgtcca catcaccatg 3366421 tgggcagact cagggttatt ggcgacaaaa tcccaaaatg tatcgtgagc agtcgcagcc 3366481 tgaggcattt cattgtgtgg ctcaggctta aacgcgtgaa ccaaatccgg aaatttgatt 3366541 gcgtcctgaa tgaaaaacac cggaatgtta tttcccacaa ggtcatagtt tccttcttca 3366601 gtataaaatt ttgtcgcaaa gcctctggca tcccgcaccg tgtctgcgga gcctttagaa 3366661 cccgcaaccg tagaaaaacg gacaaatacc ggtgtcttca ccgaagggtc ctgaagaaat 3366721 ttggcccgtg tgtattccgt cattggttcg taaacctgaa aaaagccatg cacgccaaat 3366781 ccgcgcgcat gcacaacgcg ctccggaatc ctctcatggt caaagtgcgt cattttctcc 3366841 cggaaatgaa aatcctccat cagcgtcggg ccgcgaaccc cggcttttaa cgagtgctca 3366901 tcctctgaca ctcgcaagcc ttggtttgtc gtcattttct tcccgctgtt atcggtcctg 3366961 tactgctcaa gctgctcgtc ctttgagtgt tcatttacac gtttgttttg gtcatcactc 3367021 atgtctgctc ccccttttta aaacgaaaca ttctacagca catttacccg tggcgttctt 3367081 catataaact gctaatccgc tcattaggat ttttggtcta catataaata tgcggtcata 3367141 cacatttgaa ataagccttc ttcacagaaa gaaaggatgg aagcgcttac caaaaaagct 3367201 gttgaatagg ggaggtcata tcatgcttgc catactcggt tttgtgatga tgattgtctt 3367261 tatgtacctt attatgtcta accggctttc cgctcttatt gctttgattg tcgttcctat 3367321 tgtgtttgcc ctgatcagcg gatttggcaa agatctcggc gagatgatga ttcagggcgt 3367381 tacagacctc gcccctaccg gtatcatgct gttattcgcc atcctgtatt tcggcattat 3367441 gattgactca ggcctgtttg atcctctcat tgccaaaatc ttatcgtttg tcaaaggaga 3367501 tccgttaaaa atcgccgtag gcacagcggt tctgaccatg accatttcgc tggacggaga 3367561 tgggacaaca acctatatga ttaccattgc agcgatgctg cctctctaca aacggctcgg 3367621 catgaaccgt ttggtgttag cgggaatagc gatgcttggt tcgggggtta tgaatattat 3367681 cccgtggggc gggccgactg cgagggtttt ggcttcctta aaattggaca cgtcagaggt 3367741 ctttacaccg ctgattcccg ctatgatcgc cggcattctc tgggtgatcg ccgttgctta 3367801 tatcctcgga aagaaagagc ggaagcggct cggcgtcatt tcgattgatc acgcaccgtc 3367861 ttccgacccg gaggccgcac cgctcaagcg tcccgctctt caatggttta acctgctgct 3367921 gactgtcgct ctgatggccg cactgatcac cagcctgctg ccgctccctg ttctttttat 3367981 gactgcgttc gccgttgcct tgatggttaa ctatccaaat gtcaaagagc agcagaaacg 3368041 aatctcggcg catgcgggta atgcgttaaa cgttgtctca atggtgtttg ctgcgggcat 3368101 attcacaggc attctctccg gcacaaaaat ggtggatgcc atggcgcatt ctctcgtttc 3368161 actcatccct gatgccatgg gcccgcacct gccgttgatc actgcgatcg tcagcatgcc 3368221 cttcaccttt ttcatgtcga atgacgcctt ttacttcggt gtccttccca tcatcgccga 3368281 agccgcttcc gcttacggaa tagacgccgc tgaaatcggg agggcctcct tgctggggca 3368341 gcctgtgcat ctgctcagcc cgcttgtgcc ttccacctat ctattggtag gaatggcagg 3368401 cgtcagcttt ggcgaccatc aaaaattcac tattaaatgg gccgtgggaa caacgattgt 3368461 gatgaccatt gcggcgcttt tgattgggat tatttctttc taaatgtatg agcttgatcg 3368521 tagcattgag tgagtacgtg atttacagag gggagaagat caaataggat attatgagtg 3368581 aatagaagat tcatgccaac aacttctcat tacaatcata agagcctgct atattgcagc 3368641 aggctctttc acatttggca ttattttttt gtatagcgca cccagtcata atgagcgtat 3368701 agcggattta caccattgta ggagccaagc cattcatcga cacccgtgcc attccacaag 3368761 ttcatcatga tctttccagg tgttgtcgga atttggtttg ttgcagtatg ttttaattgc 3368821 ccgtcgacat accatttaat agagtttggc tgccaatcga atgcatacgt atgataggca 3368881 ttggctgcat caaacccgag atcaacaatc ttctcatggt ttcctgcacc atttgtataa 3368941 tagttaaatt gaaccttcgt tgtgtctttt cctaaaaatt cgatatcaat ctcatcccaa 3369001 ggagttccat ctgttggacc tgtgtaagtg aagaacgatg aaacgatccc tgtgttttta 3369061 gctggtttca ttctgacttc ataaagtcca tagccatatg tttgaacaga acggttttcc 3369121 ccgcagtcaa acttgttata agctgggctt gttagcgcta aacgcatttc acccaatgac 3369181 gtcattgata cgttattagc ccgccacgtg cagttgaaca tatttccatt cgaataacca 3369241 tctgcttttt gccaaaaacc ggagttatag ccgttaaaag ggtcaaaaaa cgatccacct 3369301 gtttgagctg aggcagtagc agtgactgca aacaaactca taaacaatcc agtgacaaga 3369361 agcagcaaca ctcgtttcag ataaggcata ttggcattcc cctttcattg aaagcgtttt 3369421 ctatgttgat cttacatgat tcttttaaaa gggaacatcg gtcaaaataa tgataatatc 3369481 gaatcttact aacttgaatc ctgtaactat catcatcttc cctctgaaaa aaataaaaac 3369541 ctaaattacc atcagcacag acagagatga tccgcactca ttgcaattta ggttttgcct 3369601 gctttatcag taacaatcct accattttca tatgtgaatg taagaaaaag tgaacacaag 3369661 gaaacacaaa tgtcagcgct ctcattatgc ttgtttaact accctttcta tgtgaatggt 3369721 taaatacagc agctcgtcac ttgtgagctt gtgctcatac tcccgctcaa tgtaggtttg 3369781 gattttcttc gtgcattcat acgcgcgatg atacttttct ttcactgtat ccagcaaaaa 3369841 atcgtcctgg ctttccatgt gagtgccgtt aaatagacgc tgcgcgaaaa actttaagtg 3369901 ggtgacgaac cgataatagt gaagcgattc ttcgttgaat tcaatcttaa aatggtattt 3369961 tacaatactc aaaatctctt gcatgacttt tgtaatgttg ataatattgg gcatctcttc 3370021 attcagctcg gcatttacaa tatgcagagc aataaagcct gcttcatcct ctggcagaga 3370081 cacaccagtc ttgtttttta ccataaccaa cgcttctttg ccgatcgcaa attcgtcttt 3370141 gtagagccgt tttgtttccc acagcaaggc gtttttgata tcaagccctt tctggttgcg 3370201 ctggatggca aagttaatat ggtcggtcag cgacacatag atgctgtcgt tgagcttttt 3370261 gccgagctgt aattttgcgt agctgataat ctcttcggat acttccatac actcgatcgg 3370321 tatatcatac aaaagggttt tgaacttttc tgatacatcc ttgttatcga gcgtgaacac 3370381 tttctcaatg cgggcttcat cgacatcatc gccggacttt ttctgaaacg cgagccccct 3370441 gcccatgacg accaattctt tcccctgttc attgaccacg ctgatcacat tattgttgat 3370501 caccttcgca attttcatgg catgtccctc caaatctact aagaacagac tatatcttga 3370561 ttgtacattc tttttgtact aggtcaatat catcagggaa agacggaagc tggtcagtac 3370621 aattcactcc gtacctgctg cccgggctgt ttttgaagca gcgcctccag atggcgttca 3370681 aatgatgcct tgtcagcttt ctgctttttg acaatgctgt tcatgatttt aatgctttca 3370741 gcactgtatt gtgtatattg ttttttcagc tgatccagct gctgtcttgt cttcttcgcg 3370801 tttttcggtg tgacttggtt gatgagtttg atcatactgt ctgcggtctc aaaaaaaccg 3370861 gctctatttt ctgtcagctg ctgaatttcg atgcggctca tatcttgatt acgcgttttt 3370921 tgaagcaagg caaccgcctc gctgttttgt tttttgagcg atttgttctc aagcttaatc 3370981 gattcgagat tctccttcgc aatgtctgct tcttcttcag tcatgctgat tcgcacgaag 3371041 tattctggat tgccgattcc ataatcaaat gcttcgctca cttgtatcat ggaactgaac 3371101 acaatggcca gctgcctgtc gcttgcgagg gcttggaaat cctgcttttt cttactgctc 3371161 atcggtttgg ctgcggtttg ttttactgtc ttttgatcac agtctgcgaa catctgagcc 3371221 tcaccttcac tttcgcatgc gctcatcaca agaactgtga ccagcaggct tatacacaag 3371281 cctattcgcc tcatgctctg tctcctctct gctgaatccc ttctggaaaa taccataaaa 3371341 tatagttaaa tggtaccaga tgcacctaac cccagcaata aatcaaaagt atgatttgaa 3371401 gcgaaaaaac ataaatattt tgtaaaaatt gacgtgcatt ccattctttt caggcccatt 3371461 tctcgtacaa tagaagtatc gttaccggag aggggctctg atgatgaaac gttttacgaa 3371521 acaagaaaac agctgggtgt tatatgactg ggcaaattca gcttactcaa ttgtcgtgac 3371581 caccgcggta tttccgttat tttataaatc agcagctgcg gaaagcggtg tcagcgccgc 3371641 tcaatcgact gcctatctgg gctataccat tgcgatttca acgtttattc ttgcgatgct 3371701 cggccctatt ttaggcacaa tcgccgacta tgaagggtgc aagaaaaagt tcttcggttt 3371761 ctttgtgtca gccggtgtcg ccagcaccgc gatgctcgcc tttatcccta gtgaacattg 3371821 gctgctattg ttgctgtttt atacggtatc ggctatcggt ttttccggcg ccaatgtgtt 3371881 ttatgatgcc tttctcgtgg acgtcacgcc tgagaagcgg atgaatctcg tctcggcacg 3371941 gggttttggc ttaggataca ttggaagcac gattccattt atcatcagta ttgctgtcat 3372001 cctgctcgca caagcagaga ctattccagt gtctgtatcg gccgcaagcc agctgtcctt 3372061 cttcataacg gctgcctggt gggggctgtt caccatccca atgattaaac atgtccatca 3372121 acgctattac atcaaaaaag aacctcatat tgtcatcaac agctttaagc ggctcggcca 3372181 aacgatgaaa cggatcaggc aataccgggc acttttcctc ttcttgctcg cttatttctt 3372241 ttatatcgac ggagtcggca cgattattac gatgtcgaca tcctatggat cagatttagg 3372301 gatcggctcc tcaagccttc tgatcatcct atttgtcacc caggtagtcg ccgcgccgtt 3372361 ttcgattata tacggaaaac tggcagaacg cttcacgggg aagaccatgc tgtacgtcgg 3372421 gatcgtcatt tatatgatcg tctgcgtgta tgcctatttt atggagacaa cgcttgattt 3372481 ctggatactg gctatgcttg tcgccacctc gcaaggcggt attcaagccc taagccgttc 3372541 ctatttcgcc aagcttgtgc caaagcgcca cgccaatgaa ttctttggct tctacaacat 3372601 ttttggaaaa ttcgcctcaa ttatggggcc gctgctcatt gccgttaccg cccagctgac 3372661 cggtaaatcc tcgactgcgg tgttcagcct gatcattttg tttgtgattg gtattgtgat 3372721 tcttgccttt gttcccgagg aaaccagcac agatgtcagc cagcagcaaa atgacctgcc 3372781 cctttaactg ggagcaggtc attcatcatt tattcgcttt attcaccttc agctgtttcc 3372841 ctttgacggt tgtgttcttc atcactttga gaacatgagg gcctttacca tttaaaatct 3372901 caacgtatga ggcgttatcc atgatcgtga tgatgccgat gtcgtcagct gacacaccgt 3372961 caattttggc aatcgttcct acaaaatcaa cggctctgat tttctttttc tttccgccgt 3373021 taaaatacag cttcataatg tctttattca gctcttcgct tttgtccttt ttgctttccg 3373081 gacggtcatt cagtttagct agaaattctg gtttcttcct tgccacttcc tcttgagaag 3373141 gtgcttctat tttttggatt tcaaatccga tatattcttc aatgtcggct aaaaaccgtt 3373201 tttcgaaggc cgtgacaaac gaaatggcct ttcctttgtt ccctgcgcgt cccgttcggc 3373261 ccgtgcggtg gacatagctt tctttttcaa gcggcagatc atagttgatg acaagggaga 3373321 tattttcaat atcaatcccg cgcgcggcga catccgtcgc cactaagtaa cggtactcgc 3373381 cacgtttaaa ttcattcatg acgtcgaatc ggtcttcctg aatcattccg ccgtgaattt 3373441 tatcgcatgg atatcccaag tcatccaatt catcggtcag ctgattgacg tgctccttcg 3373501 ttcggcagaa aatgatgcag ctgtcgggat tctccgtcat cagcacatct ttcagcaatg 3373561 aaaacttatt ctcttctctt acttgaatca ccgcatgttc aatatttctt gtggttaggc 3373621 cggccgcttt gacctcgata tgctcggggt tttgcatata ttgacggctc agcttctcga 3373681 tatcctgcgg aagcgtcgct gaaaacagca tcgtcgtacg ctcagtcggc agatgcttga 3373741 taatcgcctc cacctgctca atgaagccca tattcagcat ctcatccgct tcatcaatga 3373801 ccaaataaga gagacgatcc aacggcagcg tgcctttttc gatatgatcc agaacacgtc 3373861 ccggcgtgcc gacaacaatg tggctttttt gcttaagctc agctttttgt ttatcaaagg 3373921 aggattttcc aaatacggct gtcgctttga tccgtttaaa tcgtccgatg ttcgtgatat 3373981 cttcctttac ttgcaccgca agctcacggg tcggtgttaa aataagcgcc tgcggcttgt 3374041 tttcatccca attcgccagc tcacagagag gaatcccgaa cgaagccgtt ttcccgcttc 3374101 ctgtctgtga tttgacgaca agatcctttc gttcaagggc agcggggatc acactctgct 3374161 gcaccttggt cggttctgta tatcccagtc cttccaatgc tcgtaaaatg tcatgactga 3374221 tttgatagtt tttaaaatga ctcatgtata aactcctgtc tcttgcagat gttctcatta 3374281 tactctaatt gaccaaggca tatgtgtttt gtcgaaaaat gatgtattaa aagccagcga 3374341 ttccctggcg ttttagctcc tgaacagcca atcgcgccag tgcgtcggcc cccgcgcgat 3374401 tcgggtgcag cgtatctcca tccatataaa gcccgagtgt tctttccgga ccgatcgatg 3374461 taaagtatgc cgagctgagg acatttaagt caatgagata tgttttttcc tcttcggcca 3374521 aagctaaaat agaggccctg taccatctgt ttacagacga atggatgcct tcagaagtaa 3374581 aatcggttgc ccggccctga ggcgttgata ggatgacgtc cgctcctttc gcttttacct 3374641 gacgaatcat atcacgcatc acctctttaa actccgcttc agattcttta tgcttcggat 3374701 ttgtgtcatt aatgccaagc tgcaacataa aataatctcc gggtttaata tacttcagaa 3374761 tcgcctcaag ctgtccatca tttctgaacc ctctcgcgat ctgcccgcca gacgccatgt 3374821 ttctcacttg aaaggtgtgt ttatcgatat agtgaggcag catctgcccc cagcccgcct 3374881 gcttgctgct gttgagcgga taataattgc acaccgtcga gtcgccgccg acataaatgg 3374941 ttcgattcgt taccggctga tcagacaatt tctttatttt caaggcgctg agcgtaaaag 3375001 cggtgcctgc ctttccctct gtcaccagca gattcagctg cccgtcggtg acgggaattt 3375061 ggaacgtatc ctccgcgcca tcccctgtca tattgatgac ctgaaacacg ccctccgctg 3375121 ccacactggc ccttgccgta ttgccaagcg tcaccttcac ctcataaagg ccattcggga 3375181 gatcaacatt aaacgtgtta ttgcttttcg tcccatacgc taaaaactga accgcatcac 3375241 tcttcacacc agccccggat gccgccacat ccctcatatt ctccggtgtt tgaaaaccgt 3375301 agccctttga ccggtcatac cgatcagacg ccctgacacc aatataacca ggctccatcg 3375361 aaccgcttcc aaagtcaaac tgatacacct tcggctccgc cgccttcaca ttctcaatcc 3375421 cgccaaaaca cagcatcagc atcatcacaa aaaccgctgc catccatttt ttcatcaaga 3375481 ctccccctct atgaaaacga atacattaat gcatactcgg tgattgtttc tttatgatga 3375541 ctgaattaag aaaaaaattg cgttgaggaa taaaaatgag gggagagtct caagaagggg 3375601 aaaatcagtg tgacttcttg tcacacttga tcacatccca acctccgcaa tagaagctta 3375661 tttggttttc ttcgtcatac acataataac ggagtctttc ccattgatcg tcagtcggta 3375721 caatctccaa tgcaaccgaa tcgatggatt caaggtcatc cagctttgat gcactaatgt 3375781 tttcaaaccg caattgaatg tcacaggttt gagcagatcg ttttcattca aacacaggaa 3375841 tatgaatata acgatcatct tctttcatat agaaagaaaa ctcgtttaat gtaaatggac 3375901 ctgtatcctc atcagaaaga tgctgtttca atttctcgta ttgtgtgata ttcaaatgaa 3375961 ttccctctat ttatatgatt caccgccaat catataaatg tccacagcat cgtattcaaa 3376021 ccatatgatc cgttcgcctg agtccgttag gcattggagc ttcccttctg aaaaatagct 3376081 tttatccggt tgaggatcag tgatcagaaa aacatcatca ttgatggaag ctagcagaaa 3376141 gagaaaatct gcaatatccc ggtctgcttc ctgtaatatg gattggaaat ggaattccct 3376201 tttggccagc ttcgtcacct tgtaagcatg accttcaaaa tactcggaca ggtcttctat 3376261 aaatgaacca gtcgttatta cctgtatcat gattcgatcg taggcaagcc ctgcccaaaa 3376321 acgataaaac gactctgcat cttcaagttc gcatgccata acggtttggt caggcttaag 3376381 ctcgatcatg tccaaattgc caatactgct tatagaggtt atttccataa aatcttcccc 3376441 ttatcagttg gatagcgcaa cgcaaatctc ttgtctgact tgttcataca agagaatgtg 3376501 atgatacaga tccttatcgt ttttgatcat atccggaagt atgtcaggat acagctcaaa 3376561 aaagcttttc tccaacgaac gccgctgatg ccggggtatc cttttattcg ccagcacata 3376621 atccaaactg ccagcaacaa gcataaaaaa ctcatagatt tccgcttcaa agccgtacaa 3376681 ttcatcaggg tactgctttt cttcaagctc tcgctgtctt tttctcagtt tttgaagcac 3376741 gttgatcctc tcccttccgc aataatctca tttatttcga aacagaatag gcggatcatt 3376801 atctatcgcc tccaacagct cttcaccaaa cacagtgatt gcacatttcc acgggtctcc 3376861 caaaagtccc caggagaagt cctgatgaaa aaagaaataa tagtctccat ttggaaatac 3376921 gggaacaggc cattcgccaa attcatcctt aggcattgcc tgatgaggac taaaggtata 3376981 tccgtcatgc tgccaatcta gtgcgtacat tacatcgttc tttccagtac ctaattgaaa 3377041 tgcttttaaa atagaagtct ctaaatcact tagcactccg ctcacatcat tatgaccagc 3377101 tttactgctc atcgcgcttg agatatcaaa cactcgatat ggatcaggcg ggatgatgtg 3377161 atgacatctg cttccgggct tccattttat gatcttgttc acttctgacc agatgcggtc 3377221 ttgttttgtc tgacttaaag cgcgccaatt catcataatc tcatccctac accttattgg 3377281 atatcctgct tataaacacc agaagaggcc actgcgtaaa cagcgtaact tgtcagtttc 3377341 agctgttgaa catctaggcc ttcaccgttc gaatcacagc atgttatctc ttccatctct 3377401 tgactcacat cggcagaaat caaataaaga gacgacttaa ggtctgcact gtaacaattg 3377461 aacgtcccaa ccaaaaaacc ttcttcggat atcgcgagct gatcaaatgc ttctgagtcc 3377521 ggctctttat ccgacagaat ccacacccgt ctcacgaccg tttcatcaaa tgcggcaatg 3377581 actgcatctc cgtaatacag catataaatc aagccgtttt tttctgcaag tccataacaa 3377641 tcatctacag caggcgcatc catttcttca agctttctat caatgtgtat ttccttctgc 3377701 tgaccatcta acgtaaaaca ccacacacta tggccgttgg gattctcatc atgataaatc 3377761 ccttcatcac ataaaccgac ccaaagctgt tgtttctaat ccaaaagaca gcaggaaacc 3377821 cctgaaggca agtgaaaaac acttttcacc cttccctctt ctgaaaaaac ctttaccttc 3377881 ggctcgtacg attcgtaata aacgaagaca tagccatctg cacattgttg aaagagcaga 3377941 atatcactgt atgaaatctg ctctttcact ctaaaatccc gaacatcacc ggaaggatca 3378001 tagattgtaa tggtgatacc acctttcaac ccttttccaa tgtagacacg cccctgtgga 3378061 tcagcatgga aaaaacaatc ttgggtgttc tcgttgatga ttttattcaa ttttaatttt 3378121 ttcattggtt atgctcctag gttcgaaatg aaatgataag aataaaccat ttattagcta 3378181 ttagtaacgg acaacctagt ttcattaatc gttttgggat aaatctactt tccaattcag 3378241 ccttaaatca tttagtgttt aattggtatg cataaaacga ttgatcatca aagcgaactg 3378301 tttcagcttc tatagcaatc agcattctgt tcatgtcaat aagaaagtta gcatttgatt 3378361 gatactccgg aattatagaa tttgatagat tcccgattcc ttctggatga taactcatct 3378421 caaatacttg ccaattgtat tcttccggat ctattttttc caatctcatg tcgccaacat 3378481 ctgcactata ataagcggat gccacatttt gaaatgaaat tttatgcgta tattcacctt 3378541 catcttcaaa aaccttaata tcaagtgaga gttctttttt aaacacatta aaatctaaat 3378601 gaaggacact gcacccctta tctatataat caacccattc attaatcgtt tgatacattg 3378661 tcatcccctg cctcttttta aacaataacg ccttgccacc aagcagaaaa caaattactc 3378721 cgtatattgt ttgatccaat catttaaatc atctgttgaa tgcaaataag tttctgatga 3378781 atctttcaaa tcaatcccac ttagaaggat taacatatcc cagactctat cgtcttctac 3378841 ttcggggtca tccgcataaa cataagttcc agcccaatcc gacacttctt ctcttgttgt 3378901 ttgtccattt aagacacttt tgattttatt tatgcattct attagatttg tctcgctcaa 3378961 tttgatcacc acgtattcaa gtactaaatg attttttatt agtatgcaaa gcaccgtact 3379021 gatatttaga tattgaagct ttttccgtaa aagatatgtt ccaaaaggtt tccaatctac 3379081 caataaacaa gctcacatcc gtattccgtg tgcaatatac ataaaccaaa ctggcactta 3379141 ggctcaacca aaataaaact atgattgaga atcccttcat cgaactcaat acactccaat 3379201 aagcagtcaa ggtgctcgag acattttcca aaagaacaaa ctaacgcacc aatttcgctg 3379261 ctgtattgat gaaacagcag aacgtcccgg tcatcgtaag caacatatga ctgagatatt 3379321 ttccagatca gctgtttcgc ttccgttttt tcgagggcat caacctcacg ggtgttggct 3379381 ggtattgaat ttgataaaac cagctcaagc aattgcctgc tttgcgccag atcagcaaaa 3379441 cgataagtga agcctctttc tgcacaaggg actagttttt ctttgatttc gctcatcaat 3379501 aaacgtcttt tattctcggc gagtttttcg atcaatcttt tttgcatgag ccgcattccc 3379561 tccgctgtca atttctcaac ttcttttaaa ttgattcatc attctcttgt tttcgttgtc 3379621 gttcatgttt agatttgttc taaaaaagct tgtatcgctt atcgatacaa gctttatctt 3379681 caactgctta aaactcaccc agtgggcttt tcacaaaacg ctgggaacct ttttggcaaa 3379741 tcctcttcat cccaatcaat tctatatttt tagattcttt tgtcatacaa ataagagagg 3379801 atggtaacat ctcttattta atgttccatc aataaatgcc ccatttttat ccaatgcaga 3379861 aattatttat aattaaggaa gtttagaagg attttttgta ttttcaagat ttaattttaa 3379921 agcggtcaca aaagactcta gcttttcttc attacaatta atttcgaaca agttggagtt 3379981 cgacttactt tctttataat catcaaatat aattttaatc ttaattctgt aatttccgtt 3380041 ttcttgatca atactaagaa ataagaatgg ttcaatagtc tctaaactga tactgtcttg 3380101 atttcctttt atcatagttt cgatcccaga tatcaacacc ttatattcac tttctaataa 3380161 aacagcagaa aaatcgcgaa cgacggcttt cttattttcc aacaattcaa atacagataa 3380221 aataaatgga tcatcgtcca actcttgata ccttctcggt gttaattcaa gttctataca 3380281 atcatctttt attttggcca tatttcctcc tcatttaaag tttaagtgag ggtagttgtc 3380341 atccccccct cgcttaacct tattaacgcc ttctcttaga tttatttcct tttccgtgtg 3380401 tatggaatac gtgtttagaa cccttagctc ttgaacttcc ataagctgtg attactttac 3380461 cccttttatt taaaacaact gtagcttttt ttccaacata tttcgttgcc ccattaggtt 3380521 gttttattac ttttttaggg cttcgcacag cattcagttt ggcccttaaa ttgactccac 3380581 ggcctccatt tcttcctata gattgattaa gtccatgtct tgtatgacct gtgattttaa 3380641 ctgccttctt cgtaaactta taggcgcgac tagcaccctt aaatatcttc ccaggaccaa 3380701 aattagaagc agctgcccaa gcagcacctt tccatccttt acctgattta tatgccttat 3380761 atccatcata ggctgcaaat ccggcattta ccacaagcca tacccaatgc ccgtccggat 3380821 caacattcat cactgggtta ttatttccat aagcataccc attctgatcc aatgaatctc 3380881 cgtcgctgcc cgggtctggg tcgagcgata ggaacacgcc gtttcttggc tcgtagtagc 3380941 gggccatgag atagtacagg ccggtttctt cgtcgtattg gtagcctgcg tagcggtagc 3381001 gattgtcttt tacttcgtcg cttgcttcgg tttttgttgg atttccccat gcgtcgtatt 3381061 gatacttggc aacggttttt ccagtgctgt ctgagatcgc gatgatgtcg ccgtgagcgt 3381121 tgtagtgata gaaatatttc ttaccatttt ctgtgtagga taacagctgg ccgctgtctc 3381181 cgtacgtgta tgattttgtg acgttgttgt ccgcgtctgt ttcatacaag acgttcaagc 3381241 tgtctccgtc gtagaagtag ttcgtgactt ttccgttgac ggttttttgg attctgtttc 3381301 ctttttcgtc atacttatat gttgcgaatg gcttgtcttc gccttttttg gtaacggcgg 3381361 tcaggttatc ttctgcatcc cacgtatatg tgaatttgcc gtcggatgtg cggttgccgt 3381421 ttttatcgta agagatgctt tcatcattga cttttgtcag ctggttcatg atgttgaagg 3381481 aagcgttcac cgttttgctt gagccgtctt ttatagttgt aacggttttc cggtttccga 3381541 atccatcata tgtgtattca ataacagtac cgtcttcatg ggtttctttg acaagctgat 3381601 tcagcttccc atactcatat tgcaccttgc cgcttgctga gctgtttatc gttgtgcggt 3381661 tgccgttggc atcatattca tagctttccg tcagaatgtc tccgccgttt ttgtcaccga 3381721 tatgcagcga gcttacaagg tttctttcgt catatgaaaa acttgttccg ccgccgttgc 3381781 ccgtaataaa ggtttggacg tttccatttt catcataatc aaatgaatat gaggatgtac 3381841 tgtctttcat ctcaatcatt tgatccagct tgttatacgt aaattgattc gttccttttt 3381901 ggtccccatg aatccacgag aaggttttca gcttatcgga gtcactagga tatgtccaag 3381961 tttggctgcc gccgcggtct gtcagttcgg ttaaacggtt tttgttgtca aatgtccgtt 3382021 tctttgtggt gttctgctct ttattgacga ccgacgtttc atttccattt ttgtcatacg 3382081 tgaaaatgta cttttctgta ccgttatacg actttgattt cacccggtct gttccatcat 3382141 aagaaagaga cacttcgttg ccatttggtg aaatggtttt ggtcaggttg ctgttggcat 3382201 catattcgct tgctaacaca ttgccgagag ggtcagttgt tttgacaagc ttgcccatga 3382261 catcatattc gaatttatag gtttgatctg ctcctgcccg gatggttttg cttacctcat 3382321 tgccttcctt atcatagctg tgaaggatag acgtgccgtt agagagcgtc atgtttgtca 3382381 attggtctgc ctgatcatac gtataggttg ttttttcacc ttttgcatct gtttcagacg 3382441 ttttcttacc agtttcatcg taatcagttg aagtggcgta acctagttcg tcctcttcct 3382501 tggtcacata gttgccatta ctgtcatacg tgcttttagt cagaaggctt ccttcaatca 3382561 aacggatatc atcaaaccag actgtgcctg tcgcactctt ttggaacaga atactgatat 3382621 cgactttatt gatcggcttt gttttaggga tgacgacagc tgctcggttc cattcctgtg 3382681 ttccagaagg gaatttcgca ttgtagatgc ctgtgctgcc gtcagcgtaa gtgacattcg 3382741 cctgcagaga atagtctttt tcatctgtaa atttgacgct gcttgctttc gacattcctg 3382801 tcagtgtgag ataaaccggt ttgtcatttg cgctttgccc taagacaacg gtttgttttg 3382861 ttactgatcc ggcttgggac gcactggtcc gggcagcttt taatgataca tcatcattaa 3382921 agccttcttc agaatcaacg gatgctccgc ttacattcca gttttccgtt gctgatgtga 3382981 agctgctgtt ttgaactggg ttatagcttg atgatacttc gcctttttcc agctggactt 3383041 catcaaacca tgcttttcct ttgccatctt tatctttatg atcgacttcc atatacacaa 3383101 cagctttgcc tgcattcgct ggagtcgtaa aagtgatttg ccgttttgtc cagtcatttt 3383161 ttccggctaa tgcactgtat tcattgtgaa tccattgaat tcgtttttga tctttgtctc 3383221 gcaaatcaat gttaaaatag gctcttgatt tcgcaagatc tgttttgatt ttcccgctta 3383281 atgtataggt tgtattcggc tccagctcaa ctgtttgtgt tgctgacgaa tacccatgat 3383341 ctgttccggc agacgttgat tggctcaaga cctccaatgc ctttgatccg gaaagaactc 3383401 cgcttttatc ggcgatgact gaaattttgc cgctgtcttt agaggcagtc agattccagc 3383461 cggatttttg agcttcaaag cttccatctt tcaaaatatt agttgaagct gataaatctt 3383521 tgctcgattg aatctggttt ccatatttat cataaacagc tgctgacgat gattttccgc 3383581 tctgatcggt ttcggataca gcatccagtc cgtcataagc aatatccgtg acattgccct 3383641 cggtatcctt catctttgtg acatcgttgt ttttgttgta ttcgtatgtc tcagttccat 3383701 atgcatcttt aaccgacgta acgttgccat ctttgtcata ttgatagctt tccgttgctt 3383761 ttccggtgcc gacgtcattt ggatctacat cttctacaac attgttgcct tcatactttg 3383821 tattcgttgt aatttttaac ccttccgcat catcaatgac ctgaatcgga tttcccgctt 3383881 cattatagcc atactgtact ttccggccat ttggctgtgt catgagaagc gtctttttat 3383941 cagcatcata gctgtagaca tatgtttctt ttttagcgtt gatcgctttt tcgagacggt 3384001 gaccgctata ctgatattcg gtaaagacag gctttgcttc ggtactgtta gctgaatatt 3384061 gtttgacaag gcgcccttca ctatcgtagt catagcttgt gacagtcccg tctgtatctg 3384121 taaccttctt cagcaaatca ttctcatatg agtaggtgac tttcttattc ttaggtcctg 3384181 tgatggacgt cacatggccg ttttcatcat aggtaaatgt aagcttgcgg cctgatgcat 3384241 ctgtaatggc ggtcagttga tttttgtcat tgtaagtata gacagttgca ttgttatggc 3384301 catccactac cttttggagt ttgccgcctt ttttattgaa ataagcgttg gtttgatcct 3384361 ttgtttttaa tatgaactga tcagctgttt ctgttaattc aagatataca ccggtcggcg 3384421 gctgatacgt gccatcggct tttttcgtga atcgatgtgt cgtagcgtct tcatcgatat 3384481 acattgcccc gccatccgtt gagatgacag atgtttctgc atcagcatac cagccttgtc 3384541 caaataagtg atcagagctg tcaagactgt tgtaggttct cgataagcca agtcccggac 3384601 cgcgtccatc aattgacaaa tcttcttcat tcacaatgac attgcctgtc gcaccattta 3384661 actggccgct tgggatatca atgatagacc agtactcttc tgtacctagg aattctgcgc 3384721 cttcatggaa cgttgggtta aagggcgccg ttggaatcgt ttcaccattc gcatcatagg 3384781 cgacaagcgt gaaagaataa ttcttcttcc ctttgtaatt cccatttgca ttgttataga 3384841 caggtgatgg atcgagggct aattccccgc cttttccatc tgtatgaagc ttatagcttc 3384901 cggctttgat ttcctcagaa gtcggccaga tgtttttatt ttgggttgtc caatgatcag 3384961 catcaccaac atcaaaggac tgatattctt taccgttgta aatgttaact ttatagccct 3385021 tcgcattttg aaccttttcc catatcaaat tcacataacc cgtttgactc gattttgtat 3385081 ttgtatacaa atagccagtt acattctttg gcctagcgat atcaggaagt gccggggtag 3385141 cagccgggga tgcaatggct tcgccgtctt tgttgtatgc gataatttta aacgagtaat 3385201 ttcttttggc tccatctccc ccggcgtttt tataggttgg tccgggattg atcggcagct 3385261 ctgctccgct tccgtccttt aggtgaagag catattttcc cgccttgatt tctgcacttg 3385321 tcggccagat ctttttccct tttgtggtcc aagacgtctg atttccgaga tcaagtgtct 3385381 caaagccttt cccattgaac acctgaacct tatagccggt tgcaccggat acagctttcc 3385441 aagaaaggtc gaagtatcct gtggcattcc cattattgta gccctttgct gacggtgctt 3385501 gtgcttttcc tacattaggg ataacgggct ttgccggtgc ggacatcgct ccttcacctt 3385561 ggtcaaatat cgcactgacg ccaatccaat agtttttgct tgtagcatag cttccgccgg 3385621 aattcttata gaccggggat ggatctaatg ccaattcagc tccatccttg ccgtccagat 3385681 gcagtttata tctcttggag gcaatttctg cgctcgtagg ccagattttt ttaccttttg 3385741 tgctccacga cgtgacgttg cctgcagaaa tcgcttgata ttccttacca ttgtaaatcc 3385801 ataccttata tccttttgcg ccttcaacct ttttccagct gatatcgaaa taaccagtgg 3385861 aatcgccgtt gtgataggct ttgattgtag gtgtgtttcc ctttggaatg gtatacgtca 3385921 cttcaatata tggtttattg gcggagttcg ctgaagaaat tagttttttc caatattcct 3385981 tgccgtttcc gtttgtatga agcttaaatc catagttggc cccgccggag ttccatgact 3386041 ttacagcagc ggtcacatca taactcgccc actgtccttt atggacgtcg gcttttccga 3386101 tatttttaga tgccggtttg gtgttccatg tcacttttgc attatcataa ttgctgttga 3386161 ccgtatccag ccaaaggccg gttgcctttg ttccataata ggaatgggct acgtatgttt 3386221 ttaatgtagc tttagtgaca gtcatatttt gaattggctt taggttgtta aatttcatga 3386281 acgcatagtt tgtgcctgtt gttttgtcat aatagcccgt tttcagtaca taggccttta 3386341 aattagcatc ccatttttgt gaggaggccg aatagttcgt cgtcgggtag gcactcatga 3386401 caaacgtatc cgatgaaaca gataaagaag ttgacgggtc gatagatact ggatatacgc 3386461 gttctgggtc tttcagccag ttctcgtctg ccgtaagatg aagcaaatac ccttcttcat 3386521 tcttttccag cttatagctg actttgtctg accgttcaac ctcgccggaa agctcatcta 3386581 gttttgaatc cgtcataaaa ggcttaggca cagaaaaaac aacttttcct ttttcatcag 3386641 aaaaatcaat ggatccatcc tcttgttctt tagcctgcaa atcggttttt aactgaaatg 3386701 taaatgtgtt gtatccatta tactgatgaa ggactaaatc ttcttttatg ttttcattga 3386761 atgtgaaagt ctgaagatca atattcggaa acacatccgg atacacaatc tcattactgt 3386821 cagtcttata atctgctgag gtatctttcg gagtaagtga agttttattc gggcctttcg 3386881 cttctgctag tgaatatgta accttatggt cattatgctc aaaagtcgca taaagcccgt 3386941 tcttcatttg cttttgaaaa tctgaattca aaatagcgtt ctctgtctcg acttgtttgc 3387001 ttgtcgactc ttttaactca ggagaaatgt cttcccagtc ggcatccggt gtttcctttg 3387061 tatgaatagg atcaaggtat acttcctgtt tatagacacc gtcaccttca taatagagtt 3387121 ttgtattttc tgttctttca gaggtgatct caccctcttt gtttatatct tttggatcaa 3387181 aaggtacagc ttcctcagtt tgttctttct gaagagtttc ttctggatca tcggcagcaa 3387241 tacggtttcc attctcttct tctgtagatt ttgctagtac atcggctggc actaatgaaa 3387301 tcattaaagc caacactaaa aatgctgcaa tgaacctttt aaagtttcgc ctctttcttt 3387361 ttttcatttc ctctctcctt ttgtaataaa agtaatattt actcaataat cttaactaga 3387421 ctgaaatatc attacaatat ttttctagaa aatttatctt attttaagga ttagcgagag 3387481 tcaattgacc taaaacaaaa aaaggccgca taggcctttt tacatttttt attgtatttg 3387541 ttcaatatcc gtaccctcag ctgtcacatt cgccttcccc tgcctcctga caagcgtcaa 3387601 ggccatgccc gcaaagatca ttacgatgcc aagcgtttga tagaggtcag ggcggaagcc 3387661 tgtgaagacg gtatcgagca cgatcgcgac agcggggtcg agaaatacaa tgattgaaat 3387721 aaatttcgtt gataaaaatc gtaaactgtc aaaaaacagc aaatatacaa tacccgtatg 3387781 gatgatgccg gtagatacca ccataatcca gtttccctga gataggtccg caaaagcgcc 3387841 aaagtgaata aacggaatca ggatgataac ccctaaacct gtctgcaaga aggtggtcgt 3387901 gtaaggactg agattgtgaa tgccttttcc caataaagtg gtgaacgcat aaaacagtgc 3387961 ggcgagaact gcccatatga tccctgatcc catcagctgt gtcaatgatg tgctgccgtt 3388021 aatcccggaa atcagcgcag tcccaagaaa gcagatgata atggagctga cggagatcac 3388081 atttaatttc tctctgtaga agaagctccc cagaagaaga acaagcaccg gcgctagatg 3388141 ataaacagag atggcaattg taacggacgt ttcttcaaaa gacttaaata agaacaccca 3388201 gttgaataca agaaagaaac cgcacgccaa tgtttgcagc acgtctctct tgctccattt 3388261 ttcagtttta tactggccgg acgccagcca gcaaaagcct aaaaacagcg tcgcgcaaag 3388321 gcagcggaca aagaccaatt caaatgacgg cagattggta tgctctgaga aaaagccgat 3388381 ggagccgaaa atcaccatag agatgaccat tttgattacg gctgttgatt tttgttttga 3388441 cgatatggaa ggatcctgtt gcatcaaacg tattctacct ccaatactgc atagcataaa 3388501 ctgttttttg tgaattcaga aatctacaca tagaattcct cttttttaca tgtagatatt 3388561 ataacacttc tattctaaat aaaaaaaagc gcccaagggc gcttttttta caaatctatc 3388621 gaacaatcaa aaccgggcat gttgataatt gagacacttt atggctgacg cttccaagca 3388681 tcatttcttt caggccgctg atcccccggc tgccaactac aatcaggctg acgcctttct 3388741 cttttgcgtg atttagtatc tcatgcgccg gctcgccatt cgcgtaaatg gtttcagctt 3388801 gaacgccttt ttcggctgct ttttcttttg cattctcaag gattttcagg ccctcttttt 3388861 taacctcgtt cctgatttca tcaataaagt gttcaggcac atagacaatt cccgtcagag 3388921 aagaagtcgt gacgacggct tctctcccca catgaagaat gcttagttcc gcttgttgct 3388981 cttttgccaa atgcactgcg gcatcaagcg cttttgcact catgtctgat ccgtcaatcg 3389041 ctactaacat tttgttaaac atgctcttcc cgcctttcgg actgtgggtg gttcatcttt 3389101 ctcttttatt gtccgcctgc atttcgttat tgtcaattga agcgcatgag ttttcaaaaa 3389161 attgtcagag actctctccg tttgtggcga taacctgctg ataccagttg aagctttttt 3389221 tcttgatgcg gttaaatgtt ccatttcctt cattgtcccg gtctacataa atgaagccgt 3389281 agcgcttttt catttccgca gtagatgcgc tgacaaggtc aattggcccc catgatgtgt 3389341 atccgattaa ttcaacgccg tccgcaatgg cttcgcgcgc ttcaattaaa tgatcacgca 3389401 gatagttgat tctgtaatcg tcctgaatcg tgccgtcctc ttcaaccttg tctacagcgc 3389461 caaggccgtt ttcaacgatg aacagcggct tctggtaacg gtcgtataag gtgttgagcg 3389521 tgatgcgcaa gcctttcgga tcaatctgcc agccccattc tgatgatttg aggtaagggt 3389581 ttttgactcc gcccagcagg ttgccccctg attttgcaag ctcttccgga tctgtgctcg 3389641 ccgccatcga catgtagtag ctaaatccaa tataatccac cgtatgttct ttcaagagct 3389701 cttcatcgcc ttcagccatt tcaatttcaa tattgttttc tgccagatag cgtttcatat 3389761 atcccgggta tgcgcctctt gcctgaacat ctgagaagaa aagtgttttg cgctcattct 3389821 ccattgccgc gaagacatcc tccggcttag aagtcatcgg ataggttgtc gttgccgcta 3389881 tcatacagcc gattttcgaa tcaggaatga tgtcgtgacc cgctttgaca gcaagagcac 3389941 tggccacaaa ttggtggtgt gccgcctggt acatcgcgtt taatttgttt tctccttctt 3390001 caaaaacaag accgcctccg gtaaatggcg catggagcac tacgttaatt tcattaaacg 3390061 tcatccaata cttcactttg tgttgatagc gtttgaaaac cgttttggca tagcgttcat 3390121 aaaactctat gactttgcga ttcttccagc cgccataatt tttcactaaa ccgagcggca 3390181 tctcataatg agagatggtt acgacaggct caatatgatg ctttaacagc tcatcaaaca 3390241 gatcatcata aaatctgagg ccttcttcat tgggctcctc ttcatcgcca ttcggaaaaa 3390301 ttctcgtcca cgcaatcgat gtgcggaacg ccttaaatcc catttctgca aataaggcga 3390361 tatcctcttt ataacgatga taaaagtcaa tcccgttgtg atacagattc aaggaagtca 3390421 ttgattcatc aaatggagac atgatcccgt tcggcgatac gtcagctgtc gaaagcccct 3390481 taccaccctc gttataagca ccctccactt ggttggcagc aactgcgccg ccccataaaa 3390541 atccttctgg aaatcgtttt tcatttgaac tcatattgat caccccatta gttttttcaa 3390601 gataaagcaa gcagcgcttc ttttggctgc actttaccga tctctttcac cggcgaaaac 3390661 gaatattggt ctgtgttggt cacaatcacc ggggtaatga cgtcatatcc cgcggctttg 3390721 atttgctcca gatcaaagga cacgagcgga tctcccggtg cgaccttgtc gccttctttg 3390781 atgtgagccg tgaaccattg tccctccagc tttaccgtgt ccaatccaat gtgtatgagt 3390841 atttcagctc cctgatcact cgtaatgcca attgcgtgtt ttgttttaaa aatggtggta 3390901 acgcttccac gaacaggcga aacaacttct ccttcttcag gctcaatggc aaatcctttt 3390961 cccatgaccc cagcagaaaa cactccgtct ttgacttcac ttaaggcttt cacttctccc 3391021 ttaatcgggc tgtgaatgat ctctctgctg ccttcatgca ctgccggctg ctggctgccg 3391081 tcagaaggca catcctcgaa tccaagcaaa tacgcagctg ctgttcccgc cgcaaacgca 3391141 atcacaaggc cgatcatcgc gtaaataaac gttgggccga taaagacagg gatgctcggc 3391201 agacctgcat tccccccgac gatataggaa gcaacacccg tcatgccgta aaacgcgcca 3391261 ccggctgcac cgccaatcaa agcggccgca aacggctttt tcaatcgcat attcacgccg 3391321 tacatcgcag gttctgtgat ccccatcagc gccgtgatgc ttgtggtaag cgcgagtgat 3391381 ttaaattttt tgtttctaga gcgaaggaag acggcaaatg atgctcccgc ctgccccata 3391441 ttcgccaaaa acatagccgg cagtaaataa tcgtggccgt tttgagcgat gttgttgatc 3391501 atgatcggca caaaggcata gtgcatgccc gtcataatga ttaaagagaa tgtacccgcc 3391561 agcaaaatca ttgccacaag ccctgcatga tcaaacaaat aattgacccc agaagacaag 3391621 tattctccta aaatagcgcc aagcggaccg actgtaatca atgtcagcgg cacgacaatc 3391681 aatagcgtga atgtcggaac cacaatcaat ttgagagatg cgtgtgtaaa acggtcaatc 3391741 catttttcca cgtatgaagc aatccaaatc gacagcaaaa tcgggatgac cgttgacgaa 3391801 taagtggcag cggttacagg aagcccgata aaggaaatcg gtttccccgc accgagcagg 3391861 gctgtcaaat ccggatgcag gatcgccgcc gcaatggcag ccgctacgta cggattgctt 3391921 ccgaattttc tcgccgcact catcgctagc aggagcggca ggaagtagaa cgcaccgtca 3391981 ccgacagccg tcaaaatgac atgaacctgg ctcttctccg ccatccagcc aaacgtgact 3392041 gccagcgcca caagtccttt gatcatcccc gctcccgcaa tcgcaggcag aataggggta 3392101 aacaccccag aaatcacatc aaagaccgca ctcagcacat tctttttctg agaggatgaa 3392161 ccagcgctct tttcatcact gagattgctg tgccgcacaa tcgcctgata caccttcggc 3392221 acatcgtttc cgataatgat ttgaaactgc tcgccgctga tattggtgcc catcactcca 3392281 ggcagctgct ccagctgact gcgatccgcc ttcgcgttgt catgaagatt aaaacgcagc 3392341 ctcgtcatgc agtggatcac gcgctgaacg ttttcttcac cgcctacgag ttgtaatatg 3392401 tccttcgata atttatcata atccatgtgt atacctcctt tttatggggg gactgctgga 3392461 tgaaaggtgg ccgcctttca ccagcttttt ttgtatcaaa tgctgcatca cctcctaaaa 3392521 gagaataaaa aaacctaaat gacacagatt gcgagagtct cctcctgcac ctgcaccatt 3392581 taggttttgc ctgctttcgc agtaacaatc ctgacgggtc gttttatttg tttgtaggta 3392641 tactttagca ctagattcgt gagatgtcaa cgctttcatt tttggtgttg actatcgttt 3392701 ctagaacaaa agtaatcata aagatttgaa cttagtatta acttcaataa aaaattattg 3392761 taattaaaaa ccttgaaagg cattttttcc aatcaaggtt atgaatcgtt accgtttaaa 3392821 tttttttaaa gacttcttta tctgtactat tacattcttt agccaatcta ttggttctaa 3392881 attaaacgca ggaagataca cgccatctgc gcaagattga atgtaatcgt ttttcttatt 3392941 gtctgaatgc tcactttcaa taaaatccgt taaaaagaca atagcatcct ccaaatattc 3393001 cttactttcc tctattaata actcttgtat agcgtcatca ggagtttcaa tatcttgatg 3393061 gaatgttcca gctaaaaact gaaaaacagg gtccttctgt ttattgatca ataacatgtc 3393121 atcttgctcc tttaagggag aggtaacggg ataatgttaa aatcattcat catctaataa 3393181 atcaagataa tactgatcat tctcttctat ttttcttaag aactcggtaa gagaagttgc 3393241 aatttgaata tcataatagt aaatcggatt tttattatta tcatttaatt caattgacat 3393301 taatgccgat tcactacctt caaaaaatat taatttatca ttctcaaact catcatatat 3393361 ttctatgtca ggataaaatt caaagtcatt tatcctcaat cgaaagtctc ttacagaata 3393421 tggatccaaa atgcgattag tattaaactc tgatccttta ataaacccat agccaacttc 3393481 taaataaaaa ttcactaatt cactaggtaa ttttaagttt aaattttttt caacctcttc 3393541 aatctcactt tgattcactg gataaaaatc attttctttg tttgatttta taaaattata 3393601 actcattttt ttttgcctcc tttaaataat tcatttgctg gtgagcctgt accatgaatc 3393661 ccagcttgat gctcgttagg aaattttgct ggatgcatat tccaccattc atgttctccg 3393721 ccaaaagtat tttcaattat atggtgagca tcatacttat cccctttttt tctaataatt 3393781 ttacctgttt tttcagatac aacattttcc ttataaacag gccatttttg tccagtgttt 3393841 tcttcccatt cttttataac tttatttttt actttatcaa atttagtcct gtgttttgca 3393901 gtctctattg gtgacatttt tttatattct ttatttctta atgcttcctt taatttatct 3393961 atttgatttt taggtaattc tctacctgtg cgttgttcta tatctctagc atactttttt 3394021 attaaatcag aattaatttt attagcagat ccacttacat cattcgcaat tttcccttta 3394081 tccttagcaa cgtttttaac ttccgaagcc ttcttagcct ttttcccatt attaataagt 3394141 ttattaatat ctattaactt ttctaactta gctattttgg caaatggtac tgagtttatg 3394201 gaggcaacaa cacggtcttt ccctgtgact ttttcgcctg ataccggatc tctgcccgtg 3394261 gctgctttaa atagatcata cacgccggta agttctacag ccgtctctaa aattttcaca 3394321 tatccattct catccacttt aatgtccgaa agcgagacga caggttcaag cttcatgtca 3394381 ttaccagata tgtatacatt gtaaagtgta tcattataaa cgacttgctt aacctctgca 3394441 tttgagaaat cagtttttat atgttctcta tgttcactcg tattatacac tttaccattg 3394501 ataacgatga tatttttact taccttttta gaatcacccg ttttgacaac tgaatccact 3394561 ttagactttt cattctcggc taatttcttc agcatcatct ccatcggtga atcatccgcc 3394621 tgcttcattt gcgggttaat cgcgccgaag atttggttga tgttttcttc ttcctgtgat 3394681 ttcaggatgg agccgctttt gtagcctgtg atttcaattt tcgggccggt gtacatggtt 3394741 tcgagctgat caatgtattt tttcatcgtt tgaaaatctg attttgcggc ttctagtgct 3394801 tgggtttgct ggccgtcaaa ttgaaagagc ttattcaggg tgtctgaaat cagccgctca 3394861 gcctgttctg tttccatccg aaaaaaggaa tcattgactg tcggcaggct gacgatgtga 3394921 tctatggctg atgtctggcg attgactgcg tcagtgagct gctctgtcac ttctcgtgca 3394981 tgcttgaccc catgtctcgc atcgtgtgag agaaaagcct ctgcgatcat gccgtgggag 3395041 ttagattcta cagaggaaat cgcatgctgt gtttgtttca gcactttttt gtattcgtcg 3395101 ataaatatgc caaagaaaag gagaaaaggc ttgtggcact cctcgtaaaa ggtccggatg 3395161 gcatctccgc cttttccttt cagcgcatcc ttcatgcctg ccagatgctc aacgcttttt 3395221 tccagcttct ccagctgttg tttttgcttg tccagtttct caatcgtatg ctgaatgccc 3395281 tcgtgaagag cgtggacatc taatgttttc aatcccttgt cctcccgcgc tttatttcat 3395341 ggaagatgat atgttttcgt ccgtttcctt catggcgttt accgcgcttt ccgtttgtgc 3395401 gatatgcttg gccagaacag acgcatatgc ttcagtgagc tctttgatgt ccttatttaa 3395461 ttgctcgatg gacttcacaa cattcaaatg gtttctgcct gagagatgac cgggcaatga 3395521 ggacttgagt tcagctgaat tcttgagctg agaaagccct tgcttcactg tgtcatacac 3395581 cattttaatt tcctgtgcca tttgtgctca cctcactttt tatgtttttc cttctctatt 3395641 tcatgctcta tcctcgtgat ttggcgtctt atagaataca catcgccctc taatgagtgg 3395701 atttttcctt ctatgctttc gatgattccg ctgacttgat cgcttttgat ttgctgatat 3395761 gctttgttca ttccttcacg aatatcttca aaccgctcag catgtgttcc tctccatgcc 3395821 tcccggttaa gatgaggccg gtgaatgaga tgctgggcct cagagaaatc gtgtttgatt 3395881 tgcctaattt cgtgcagcac tcgttttaat tgatggatct gttcctgctt ttcatgtaag 3395941 tcggctttta ccgaatgtaa caacatttca ctatgcatgc cgcaacacct cgtgtttcta 3396001 tcaaactgtg taaattcttt acaatacaga ctattttcat attacatgat gggtcatatt 3396061 ggataaatag gtaaaaagga ttgtcttgag aggtatagaa ctggttctaa attgctaaaa 3396121 atacgatctc atcaccctat gaaaggagaa aacaatcata gtagggactt tttatttaag 3396181 cctttaatct ctcctccagt tctaattttt cctcccactt aactgtttct tatagtcaat 3396241 aaagctcata aaaaaacacc ttccctcgaa ggcgcttctc catcttattt agatccccat 3396301 acagcctcac cgctggtatt cagcacacta aacgtcatga cgttcttctc tctcaccgaa 3396361 tcccactggc gtaaaaatac cccgttatac ttcttgcctg ctaacgtgat gtcggcggtg 3396421 ttttttccgg ttttcctcca tgttccggtc atttccccgg aaatggtgtg gtttttgttg 3396481 agctggatgt tgatggtttg tttgatgtcg gctgagatgt cttttccgtg ctggataagt 3396541 ttgtatgttc ctgtgatgtc tttttgtttt acttctttca atgtttcgcc cgcataacga 3396601 tatggtgctg ctaccggcca gccgtctttg ttcatgaaca attggtggac tctgacttcg 3396661 tgttcttcac ccctgcccgg gaagcgggtg tggaagatta aataggaacg cccggttttt 3396721 tcatcatagt atgcggagtt gtggcctggt gagacgtacc cggtgccttt ttcattttct 3396781 gtttcaaaag tgtagctgcc catgagtttg acgccgtatg gttcgatgga acggtcgtcg 3396841 aagaatgtgc ctcccttgcc gcggacgtcg agcattggat tgccttctgc atcatagtaa 3396901 gggccgtccg gtttcttgga gcgggccaca cggatgttgt agccgcctgt tgcatcgaga 3396961 ccgccatatg ataggtataa gtagtagtat tgggtgtctg gattgtagag aacatacggg 3397021 ccttcgattc tgctgtggtt gccgccgagc agttttttcc catatccctg tccaggaagc 3397081 gggaagcccg ttttcggatt catttcaagt atgaaaatgc cgcctgagta tgatccgtac 3397141 accatccaca gcttgccgtc tttatcaaag aaggtatgcg ggtcgacgac attcggatgt 3397201 ttggttgcat catacggtgt tccatcgctg cttgtgcctt ccattcctga tttcaaaaag 3397261 atgcctttgt ttttgtatgg gccttcgatg ttgtcagcaa cggcaacacc catggcggat 3397321 cttggcgaat cgccgcggca ggcgttgtag tacatgtagt atttgccgtc cgccagctgc 3397381 gtgacgtcag ccgcccaaag agtatcggat tgcgcccatt cgaaggtttc ttttaattct 3397441 tcatagacat tcgggataag tgggttgtca ttgcttacgc tggtggtcag ctgctgccat 3397501 tgcatgaggt cattcgattt agctgaagcg agatgagatc caaaaacata aaaagtgccg 3397561 tttgtttcaa tgatggaagg gtcatggacg ctgacttctt taaatatagg tttttgtgca 3397621 tagacggagt ttgggagggt gaaggccatg ataagagctg caagaaaaca tacacggaac 3397681 aatcggttga acatctaaac aattcgcctc tcttttttat taaattttaa acgcttacat 3397741 ttctctatga agataccccg gcctattaaa acagccgaat gttttcatat tcatccagat 3397801 aggtgatttc tcacttcact tacatagtca gactgatgtc tgtctgtttt gcgcagaact 3397861 tgttgcttgc atatcctctc cttcatagtt caactctttt gctgtttctc cttcttgcat 3397921 cacgtctgtt tttctttcgc gtacatgtaa taactgcttt gtcaggtttt gcatcaactg 3397981 tgatacagcc atttcgttgt cggcgttttt taagatgatg cctgattgcc cgtcaacacc 3398041 agagtcattc ggctggctct ttataaaacg ccttgcgaaa aatacgactt agtaaacgca 3398101 tattgagagt tagacagcgg cgcttgcctc cttgtctgga tatcgtgtgc aatcgctgaa 3398161 aaaacctgtt ctgctttctg cgtcacgcta ttacaatagc aatctaactt gttaaagact 3398221 ataaaaaaac cttttgactt ctgctgctga accaattaat ataatactca gttaatagtt 3398281 atcagaattt ttaggaattg agtgattcat atgacactgc ataaagagcg tcggatcggc 3398341 cggctgtctg ttctcctgct gctgaatgag gcggaagaaa gtacgcaggt tgaggagctg 3398401 gagcgagacg gatggaaggt ctgtcttggc aaggtaggat caatggacgc acataaagta 3398461 gtagccgcaa ttgaaaccgc ttccaaaaag agcggtgtca ttcaatctga gggttatcgg 3398521 gagtcacatg cgctttatca tgcgacgatg gaggctttgc atggcgtgac cagaggtgaa 3398581 atgctgctgg gatcgctgct tcggacggtg ggattgaggt ttgccgtttt gaggggaaat 3398641 ccttatgaaa gtgaagcgga aggcgattgg atcgctgtct cgctttacgg aacaatcggg 3398701 gcgccgatta aaggtcttga gcatgaaaca ttcggcgttg gaattaatca catatgaaac 3398761 agcccataga tcttagacga tagggggcta tgcgtgaaaa cagaagttca cagcatagct 3398821 cctttttgta tgggcgcttt accaaagtaa agaaaaagga gttgggctta tggtgacttt 3398881 agacggttct tcattgacaa cagccgacgt cgctcgtgtg ctgtttgatt ttgaggaggc 3398941 agcggcttct gaggaaagta tggagcgcgt gaaaaaaagc agagcagcag tggaacggat 3399001 tgtacgcgac gaaaagacaa tctacggcat caacaccgga tttggcaaat tcagcgatgt 3399061 cctgattcag aaagaagact cggcggcgct gcagctgaat ttaatccttt ctcatgcctg 3399121 cggagtcggc gacccttttc ctgagtgtgt ttccagggca atgctgcttt tgcgcgccaa 3399181 tgcgctgtta aaaggctttt ccggtgtacg cgctgagctg atcgagcagt tgcttgcttt 3399241 tttaaataaa cgcgtccatc ctgtcatccc tcagcaagga tcacttggcg caagcggaga 3399301 tctggcgccg ctttcccact tggcgcttgc gctgatcgga caaggagaag tcttttttga 3399361 gggggaaaga atgccggcaa tgacaggctt gaaaaaagca ggtattcaac cggtaacgct 3399421 gacatccaag gaagggcttg ccttgattaa cgggactcag gccatgactg caatgggggt 3399481 ggtcgcctac atcgaagctg agaaactagc ctatcaaaca gaacgaattg ccagcttaac 3399541 gattgagggg ttgcagggaa ttatcgatgc atttgacgag gatattcact tagcccgcgg 3399601 ctatcaggag cagatcgatg tcgcagaacg aattcgcttt tatctatctg acagcggcct 3399661 gacaacctcc cagggagaac tgcgggtaca ggatgcctat tcattgcgct gtattccgca 3399721 agtacacggt gcgacttggc agacactagg atatgtcaaa gaaaaattag agattgaaat 3399781 gaacgcagct acagacaatc cactcatttt caatgacggt gacaaagtga tttccggcgg 3399841 aaactttcac ggacagccaa tcgcctttgc catggatttt ctgaaaatcg caatatcaga 3399901 gcttgcgaat atcgcagagc gtaggatcga acgacttgtg aatccgcagc tgaatgacct 3399961 gccgccgttc ctgagccctc atcccggtct gcaatccggt gcaatgatca tgcagtacgc 3400021 cgcggcctca ctcgtttctg aaaataaaac actggcccat cctgcaagtg tggattccat 3400081 tccgtcatcc gccaaccaag aggaccatgt cagcatggga accatcgccg ctcggcatgc 3400141 ttatcaggtg atcgcaaata caaggagagt cattgcgatc gaagccattt gcgcattgca 3400201 ggctgttgaa tacagaggca tagaacatgc agcgtcctat acgaaacagc tttttcaaga 3400261 aatgagaaaa gtcgtgccgt ccattcagca ggaccgtgtt ttttcctatg acattgaacg 3400321 cttgactgac tggctgaaga aagaatcttt aatacctgat catcagaata aagaactaag 3400381 ggggatgaac atatgactga tgtaaaaaaa tcaatccgtg ccaacagagg aacagagctt 3400441 gaatgcttag gatgggagca agaggcagtg cttcggatgc ttcgaaacaa ccttgatcca 3400501 gaagtcgccg agaagccgga ggacctcatc gtatatggcg ggattggcaa agccgcacgg 3400561 gattgggacg cttttcacgc cattgagcat tccttgaaaa cattaaaaaa tgatgaaaca 3400621 ttgctcgtgc aatccggaaa gcccgttggc atgttccgta cacacccgca ggcccctcgc 3400681 gtgctcctag caaattctgt tcttgttccg aagtgggcag actgggagca tttccacgaa 3400741 cttgagaaaa aagggttaat gatgtacgga cagatgacgg ctggcagctg gatttacatt 3400801 ggctcacaag gcatattgca aggaacctat gaaaccttcg ctgagctggc gcgacagcac 3400861 ttcgggggca gcttaaaagg aacgttgacg ctgacagcgg gtctcggcgg aatgggaggc 3400921 gcccagccgc tgtcagtcac gatgaatgaa ggcgtcgtga ttgccgtcga ggttgacgag 3400981 aaacgcatcg acaagcggat cgaaacaaaa tactgcgatc gaaaaacagc atcgattgag 3401041 gaagccttag cttgggctga agaggcaaag ctggcaggaa aacctttgtc cattgcactt 3401101 ctcggaaacg cagctgaggt gcatcacaca cttttgaacc gaggcgtcaa aattgatatt 3401161 gtgacagatc agacatctgc ccatgaccct ttaatcggtt atgttcccga gggctattcc 3401221 cttgatgaag ctgaccgttt gcgtcaagac actccagagc tttacgtgcg ccttgcgaag 3401281 caaagcatga aaaaacatgt cgaagccatg ctggcctttc agcaaaaggg ctctattgta 3401341 tttgactacg gcaacaatat ccggcaagtc gcaaaggatg aagggctgga gaatgccttc 3401401 gattttccgg ggtttgtccc tgcctacatc cgccccttat tctgtgaagg aaaagggccg 3401461 ttccgctggg cggcgctttc cggagatccg gcagatattt accgtacgga tgcgttatta 3401521 aaagagctgt tcccgacaaa taaagccctt caccgctgga ttgatatggc acaggaaaaa 3401581 gtcaccttcc aaggcttgcc gtcccgtatc tgctggcttg gatatggaga acgaaaaaag 3401641 atgggcctcg ccattaacga gctggttaga accggggagc taaaagcgcc tgtcgttatt 3401701 gggagagatc atttggactg cgggtctgtc gcctctccaa accgggaaac agaagcgatg 3401761 aaggatggaa gtgacgctgt cggtgattgg gctgtgctaa atgcgcttgt caacacggcg 3401821 gcgggtgcaa gctgggtttc cttccaccat ggcggcggcg tcggaatggg ctattccctt 3401881 catgccggca tggttgcagt ggccgatgga agtgagctgg ctgacgagcg gctcgcgcgg 3401941 gtcttaacga gcgacccagg aatgggcatt atccgtcatg cggatgcggg ttatgaacgt 3402001 gccgttgaag tagcgaagga acaggacatt atcgtgccga tgcaaaaata aaggagtgat 3402061 gacatgccaa agcaaattga tacgattctc atcaacatcg gtcagctttt gacgatggaa 3402121 agcagcggtc cgcgggcagg caaaagcatg caggatcttc atgtgatcga agacgctgtt 3402181 gtcggcatcc atgaacagaa aattgtgttc gccggacaaa aaggggctga agccggttac 3402241 gaggcagacg aaatcattga ctgttcggga cgccttgtaa cgcctggcct cgttgatccg 3402301 cacacccatc ttgtatttgg cggatctcgt gaaaaggaga tgaaccttaa gcttcagggc 3402361 atttcatatt tggatattct ggcgcagggc ggcgggattc tgtctacagt caaggatacc 3402421 agggcggctt cagaagaaga gctgctgcaa aaagcccatt ttcatctgca aagaatgctg 3402481 tcctacggca caaccacagc agaagtgaaa agcggctacg gcttggaaaa agagacagag 3402541 ctcaaacagt tgcgtgtcgc aaagaaactg catgaaagcc agcctgttga ccttgtttcc 3402601 acatttatgg gagcccatgc gattcctccc gaatatcaaa acgatccaga tgattttctg 3402661 gatcaaatgc tttccctttt gccggaaatc aaagagcagg agctcgccag ctttgctgat 3402721 atttttacag aaacaggcgt ttttacagtc agccaatccc gccgttattt acaaaaagca 3402781 gctgaggcag gcttcggatt aaaaatacac gcagatgaaa tcgatccgct tggaggtgct 3402841 gaattagcag gtaagctaaa ggccgtctca gccgaccatt tggtaggtac atcggacgaa 3402901 ggcataaaga aattggctga ggcaggaacg atcgccgtcc tcttgccggg cacgacattt 3402961 tatcttggca aaagcacata cgccagggca agagctatga ttgatgaagg tgtatgtgtc 3403021 agcttggcaa cggattttaa tcctggcagc tcgccgactg aaaatatcca gctgattatg 3403081 tccattgccg cgcttcatct gaaaatgact gcagaagaaa tatggcacgc ggtcacagtc 3403141 aatgccgcat atgccatagg aaaaggagaa gaagccggtc agctcaaagc tggccgctca 3403201 gctgatcttg tcatttggca agccccgaac tatatgtata ttccgtatca ctacggggtc 3403261 aatcatgtac atcaagtcat gaaaaatgga acaattgttg tcaacaggga gggagccatt 3403321 cttggataag tacccttttc tcagagaggc cggatcttcg tttaaagacc gggatgtcac 3403381 aaaaatgagc gacctgatcg caacatggga cggccaggac attaagggac cggcgttgat 3403441 aggtgtcccc ctatcaaaat cctccatcag tcattcaggc gcttcctttg cacccggaac 3403501 aatacgccag gctctgaaac attcatcagc ctattctgct gagcttggag agcacgtcgt 3403561 atcagagctt ctatatgacc tgggggatat cgatattcat gtcactgata tcgtaaagtc 3403621 acatcatcac attttccaaa ccatgcacgc tctgctttcg gatcatccgg attgggtgcc 3403681 gctcatactt gggggagata actctatcag ctactccaca ataaaagcga tagcacaaac 3403741 aaaaggaacg acagcggtga ttcaatttga tgcccatcac gatgttcgca atacggagga 3403801 cggggggccg acaaacggca cccccttccg ccgccttttg gatgaagaga tcattgaagg 3403861 tcaacatttg atccagctgg gtatcagaga attcagcaac agccaggcct atgaagcata 3403921 tgcaaaaaaa cataacgtga acattcacac gatggacatg atccgggaaa aaggactaat 3403981 cccaacgata aaagagattt tgcctgttgt tcaagataaa acagatttca tttttatatc 3404041 tgttgacatg gatgtcttag accagtccca tgcacccggc tgtccagcga ttggcccggg 3404101 cggcctctat acagacgaat tgcttgaagc agtcaagtac atcgcacaac agcccaatgt 3404161 tgccgggatt gaaattgttg aagtcgaccc taccctcgat tttcgagata tgacaagcag 3404221 agctgcagct catgttctgt tacacgcatt aaaaggaatg aaactctccc cattcaagtg 3404281 atcttctggc aggttgtatt ttgggtataa gaaactcatc tgcctaagga atggcagcta 3404341 aaaggagggc gagacagtga atcttcagga gaacagcagc caacagctaa aacgcacaat 3404401 gaaaagcagg cacctattta tgatctcatt gggaggcgtc ataggcacag gacttttcct 3404461 cagtacgggc tatacgctac atcaagccgg acccggcggt acgatactcg cttatgtaat 3404521 cggcgggttg atgatgtacc tcgtcatgca atgtctcggc gaattgtcgg ttgccatgcc 3404581 ggtgaccggc tcttttcaaa aatatgctac aacatttatc ggtccatcta ccggttttat 3404641 ggtcggcatc atgtactgga tcaattgggt ggtgacggta ggctctgagt ttaccgcatc 3404701 cggtattctc atgcagcgct ggttccctga cagcagtgta tggatgtgga gtgcgatttt 3404761 tgcagccctt ctttttatat gcaacgcatt ttcagttaag ttatttgcgg aaactgaatt 3404821 ttggttttcc agcgtaaaga ttgtcaccat tattttattt atcattttag gaggagccgc 3404881 catgtttggc ctgatctctt taaacggaac ggcggatgct cctatgttgt caaacttcac 3404941 agatcatggc gggttgtttc caaatggctt tctcgccgtt tttatcgcga tgatatctgt 3405001 gagcttcgcc ttttccggta cagagttaat cggcgttaca gcaggagaat cagcaaatcc 3405061 tcaaaaggat ataccgcgat ccatccgtaa tgtcgcatgg agaaccgtga tttttttcat 3405121 tggcgctgtc ttcatattat ccgggttgat ttcatggaag gacgcaggcg tgattgaaag 3405181 cccgtttgtc gccgtatttg cggagatcgg aattccttac gctgctgata ttatgaattt 3405241 cgtaatatta acagccttgc tgtctgtcgc caactcaggc ttatatgctt cgacccgtat 3405301 gatgtggtct ttagcaaatg aaaacatgat cagctcccgt tttaagaaag tgacatctaa 3405361 aggcattcct ttaaatgcct taatgatcag tatggctgta tcttgtttat ctctcgtttc 3405421 cagtatcgtg gcccctggaa ctgtctatgt ggtgatggtc gcaattgctg gatttgcagg 3405481 agtcgtggtc tggatgagca ttgccttgtc ccaactcttg tttcgaaaga gatttttgaa 3405541 aaaagggggg gatgtaaaag atctgacatt tcgcacgccg ctttatcctc ttatgcctat 3405601 agccgctctc ttattatgtt ctgcttcttg tatcggtctt gcttttgatc ccaatcaaag 3405661 aatcgcactt ttctgcggag ttccttgtat catcctttgc tatctcatct accatttcaa 3405721 aagaaatgtt acaaaagcga aaaaaatcag ccaagaggaa tatccagccg atcacatcct 3405781 ataattaaaa aagcacaccc cgctcagcat gggatgtgct ttatttttta ttctgtaatt 3405841 aacgtatgaa tcagcttcgg cgccttcgct tccgcggcga tgcggatgtt gtcatagact 3405901 tttgcgatga cttcatcgac gttttctcgg ttagcgtaaa gcgttacgag cggttcccct 3405961 ttttctactt tgtcgccgac ctttttgcgg agcatgatgc cgacggctaa atcgatttcg 3406021 tcttcttttg tggcgcggcc ggcacctaac agcatcgccg cgacgccgat ttcgtccgcg 3406081 acgatttcag agacgacacc cgcttctttg gcaggcacat caatttgata tgcggcttgc 3406141 ggaagcttag acggatcgtc aacaattgag ctgtcgccgc cttggttttt caggaaatcc 3406201 ttgaatttct caagtgcttt gccgtttttc atgacttctt ccagcttcgc tctcgcttcg 3406261 tccaatgtat cggctttttt cgcaagcaca accatctggc tgccgagcgt taagacaagc 3406321 tcatgaagat cctcaggccc ctcgcctttg agcgtgtcga tcgcttcttt gacttcaagc 3406381 gcatttccga tcgcaaagcc gagtggctgg gacatgtctg aaatgacagc cattgtttga 3406441 cggccgacgt tatttccgat gcgtaccatc gctttggcaa gttcagctgc gtcttcttct 3406501 gttttcatga aggcgcccgc tcccgttttt acgtcaagca cgatggcgtc cgccccggca 3406561 gcgatttttt tgctcataat cgagcttgca atgagcggaa tggaattgac cgttcccgtt 3406621 acatcacgaa gcgcgtacag ttttttatca gccggcgtta aattgccgct ttggccgatg 3406681 accgcaacct tgtcgcggtt cacaagttta ataaattcat ccttcgtcag ttccacgtgg 3406741 aagcccatga ttgcctctaa cttatcaatc gtgccgcccg tatggccgag gccgcggccg 3406801 gacatcttag caaccggcac atcaagagcc gcaacaagcg gagcgagaac gagcgttgtc 3406861 gtgtcgccga cgccgccggt agagtgttta tccactttaa ttccttcaat ggcagaaaga 3406921 tcaatcgttt caccggagtt caccatagcc atcgtcaagt ccgcgcgttc acggtcactc 3406981 atatcctgga agaaaatcgc catagcaagc gcgcttgcct gataatcagg aatgcttcca 3407041 tctgtatagc cgttcacaaa aaattgaatt tcttcagtgg tgagttcttt tccgttttgt 3407101 tttttgatga tgatatctac cattctcatg tttggtcacc gatccttttc gattaagttc 3407161 agtaaatcaa gcccacaatt gctgctgata aaaagctgac aagcgtagca ccgtataata 3407221 atttcaagcc gaaacgagcg acgacatttc cttgcttttc attcagtcct tttacggcac 3407281 cggcaatgat tccgattgag gagaagttcg caaatgacac aaggaatacc gatacgatcg 3407341 ctgttgtacg gccgctgaaa tggaaaccgt tttgcgtaag cgacgtcatg gcgacaaatt 3407401 cattcgatac catttttgtt gccataatgc ttcccgcatt aacagcttca ttccatggga 3407461 taccgacaag aaaagcgaat ggagcaaaca catatccaag aatgccttgg aacgaaatac 3407521 cgaatactgc attaaaaatg ccattgatca atgcaataat cgcgacaaat ccaatcagca 3407581 tcgcagcgac gacaaccgct actttgaaac cgtcaagaat gtattctccg agcacttcga 3407641 agaaggattg tttttcttct tcctcaacac gaagcatatc ctcttctttt gcaacctcgt 3407701 acggattgat aatagaagcg ataatgaaac cgccaaataa gttcaaaaca agcgctgtta 3407761 caacatattc cggtttcagc attgtcatat acgcaccgac aatcgacatt gatacagttg 3407821 acatcgcaga tgcgcaaagc gtgtacaagc gctgctgatt taaaagaccg agttctttct 3407881 tcaaggagat aaatacttct gactgcccta aaatcgcaga agccactgcg ttatacgatt 3407941 ccaatcttcc cataccgttt accttgctga gggcaaggcc gatatatcta atgataaacg 3408001 ggaggacttt ccacttttgc agaatcccga tcagagcgga aataaacacg attggcaaga 3408061 gaacattcat aaagaatgtc gtttggtccg cattcaccaa gccgccaaac acaaagttaa 3408121 ttccctctgc cgcgtattca agcaggtaac cgaatccttt tgcaaatcct cccacgagga 3408181 aattccctat tccggtattg aggagaatgt agccaagaat aaattgcaaa atgagcataa 3408241 caacaattgg gcggatctta attctttttt tgccgctgct cgcgatccac gcgaggccta 3408301 aaaacacgat taaaccgata atcccaatca aatacttcat atgtgtttct cctttatttg 3408361 tattcgctta caattactgt ttcctcagaa aacggaaagc agtctgcctt ccgtcagctc 3408421 ttaatagttg tctccgcctg atgcattttc tccttttacg atagaaacgc ctgcgctggc 3408481 gccaattcgg cttgctccgg cctctaccat tgtgtctaca tcttctttcg ttctgacgcc 3408541 gccagatgct ttcacgccga tatcaggccc tactgttttg cgcattaagg cgatatcttc 3408601 cttcgttgcg ccgcctgtag aaaagcctgt tgatgttttt acgaaatccg ctcccgcaga 3408661 caccgctaaa cggcatgcac gttctttttc ttcatcagtc agaaggcacg tttcgataat 3408721 gactttgaca agcgcttttc cggctacagc ttccactaca ccgcggatat cagcttccac 3408781 cacatcgtct tccttgtctt ttaaagcggc aatattaatg accatatcca cttcagtggc 3408841 gccttttgaa atggcgtctt ttgtttcgaa cgcttttgtt tcagttgtat tggcaccgag 3408901 cgggaagccg atgaccgtac aaacgtcgac tccagttccc ttaagctctt ttgcagcaag 3408961 ctccacccat gtcggattga cacatactga agcaaatttg tatgttttcg cttcttcaat 3409021 tagttttaga atgtccgctt tttgtgtatg cggtttcaaa gctgtatgat caattatgtt 3409081 ggctaatgac atccttcgca cacttccttt tttgttaaga tattttttag cataaccgac 3409141 ttttgaacat atgtaaattg gtaattgaaa ttttgttcaa tgaaaggttt gaacgtgtca 3409201 caaatcatta acaagcgccc tcgcggtatg ctggtcaatg attaaaacgt tggcatattt 3409261 tccggttaat gctccgtgaa tggaagatac ttttctgctt ccgccggcaa ctaaaatgga 3409321 gcgttccttc agtctaaggt cttgaagctc aacaccgatg gtccggtcat tgatggcgct 3409381 gctgcaaata ttccctttcg catcaaaaaa gcgtgaacaa atatccccga cggcctgttt 3409441 tttcagcagg gctttctctt cttcgttaaa atatccgagc cgaaacaaca gcgcttcatc 3409501 acggacagtc ccgaccgtaa agagagcgat attcgcctgc ttgcccatct caatgatccg 3409561 ttcaatatga cggtctttct ccaccattcg cttcacatcc gcattatcaa acacgacggg 3409621 aagcgggaga tagcgcggca tcgtttgaaa agcctctgca aacagctgaa tcgtttcagc 3409681 cgaatacgtg tttacccggg aatggctgat gccgcctttc agctggacga cctcgacgcc 3409741 ttttacctgc ttcggctgca tgttttgcgc gatttgatac atggtggttc cccagctgac 3409801 gccgacaatg tcgccgtctt ttaccgtttc atgcatatat tctgcaccat agcggcttag 3409861 gtcatgtgta attcctgcat aatcgggtgt cggggaaaac acaacatgcg cctcaaggag 3409921 cccgtatttc tcttcaagta tggaaccgag cgcatccaaa tcctcaaaag ggtccatgac 3409981 gcgaatctgg acataccctt tttcctttgc atattgcagc agccgggaaa cggttggcct 3410041 tgaaatgttg agctgctcag caatttgctg ctgactgtag tcagactgat agtaaagcct 3410101 tgccgcttct atgcttaatt gctgtttttc ccgatccatt ctgcacctcc ctgtggatca 3410161 gtcctgataa aactgctttt gatttgcttt tattatacag gctggcgccg gctttcatcc 3410221 acctgatttc taagaaactg aaaaacgctc tgggcgcgga cctgcccaga gcttacttct 3410281 cccaagtcgg tttctctgag cataaagtta tttcgttttt cctaaactca gcggatctgt 3410341 gatcatctct tttggctata aagtttccgt tttttcaaaa caaatgtttc aaatgagata 3410401 ggaaatgggt actaatctat taactttgtt acatattttt agatactcat tggctcaaca 3410461 actgaggagg agacatttgt gaagaaagac acaaggaaat atatgatcta ctttttcggc 3410521 gctttagggg gactgctata tggttacgat acaggtgtta tctccggagc actcctgttt 3410581 atcaataacg atattccttt aacgacattg acagaaggat tggttgtcag catgctgctc 3410641 cttggcgcga ttttcggttc tgccttgagc ggcacatgct cagaccgctg gggcaggaga 3410701 aaggttgtat ttgtcctttc catcattttt attatcggtg cgctcgcttg cgcattttct 3410761 caaacaatcg gcatgctgat tgcatctagg gtgatactcg ggttggccgt cggcggttca 3410821 acggcacttg tgcccgtgta tctttccgaa atggcaccga cgaaaattcg cgggacactc 3410881 ggcacaatga acaacttaat gattgtcacc gggattttgc tcgcctatat cgttaactac 3410941 ctgttcacac cgtttgaagc gtggcgctgg atggtcggtc tggctgcagt gcctgccgtg 3411001 cttctattaa tcggcatcgc cttcatgccg gaatcgccaa gatggctcgt gaagcgcggc 3411061 agcgaagaag aagcgagacg catcatgaac atcactcatg accccaaaga catcgaaatg 3411121 gaattggcag agatgaagca aggggaagcg gagaaaaaag aaacgacact tggcgtgctg 3411181 aaagccaagt ggattcgccc tatgcttctg attggcgtcg gccttgccat tttccagcag 3411241 gcagtcggca ttaacacggt catctactac gcgccaacca tttttacgaa ggccggtctt 3411301 ggcacatcag cttcggcgct cggcacaatg ggaatcggca tcctcaacgt catcatgtgt 3411361 atcactgcca tgatcttaat tgaccgtgtc ggccgcaaaa aacttctgat ctggggaagt 3411421 gtcggcatca cactgagcct tgctgcttta tcaggcgtgc tcctgacact ggggctttcc 3411481 gcatcaacag cgtggatgac agtagtcttt ctcggtgtct atatcgtctt ttaccaggcg 3411541 acatggggtc cggtagtgtg ggtgctcatg cctgagctct tcccgtccaa agcacgcgga 3411601 gccgcgacag ggttcacgac tttggtgtta tcggcggcta acctgatcgt gtcgcttgtc 3411661 ttcccgctga tgctaagcgc gatgggcatc gcatgggtct ttatggtttt ctcagtcatt 3411721 tgtcttctct catttttctt cgcgttctac atggtaccgg aaaccaaagg gaaaagcttg 3411781 gaggaaattg aagcaagcct gaaaaaacgg tttaaaaaga agaaaagcac ccaaaaccaa 3411841 gtgctgaatg agcgtacatt ataaaaaaag gaatcgtctc cttatgagac gattcctttt 3411901 tctgtttaca ccatgacctt gcaaatattg ttcgtaaatt ccacagggtc ctgaatcggc 3411961 aggccttcga tgaggagcgc ctgattgtac agaaggtttg tgtacaggct cagcttctct 3412021 ttatcttgtt caaacgcgtc ctgcagtgtt tggaatacct cgtgatttgg gttgatttcc 3412081 agcacttttt ccgccttcac attttggctg tcaggcatcg catttaagat tttttccatc 3412141 tcaattgtca cttcgccgtc agcagcaagg cagactggat gtgatttaag ccgttttgag 3412201 attctgacgt ttttcacttt gtctgacaga atgtttttca tttcctcaaa cagatcctta 3412261 tacttgcttt cctcttcctc ggactgcttt tgatcctcat ccgtgtctat gccaaggtct 3412321 ccgcttgata cggacttgaa ttctttttcc tgataagaag ccagcatttt aattgcaaac 3412381 tcatcgatgt cctcagtaaa gtagaggatt tcatagcctt tgtccgccac catttccgtt 3412441 tgcggcagtt tctcaatgcg gtcgtaagaa tcaccggtcg cgtaataaat gaatttctgc 3412501 tcctctggca ttctggaaac atactcgtct aagctgacca gttttttctc ttttgaagag 3412561 tagaataaga ggagatcctt caattgatcc ttattcgcgc caaaatcatt gtacacgccg 3412621 aatttcagct gtctgccgaa cgacttgtag aacgtctcgt atttctcgcg gtcttttttc 3412681 aacaggcttt gcagctcgct tttgattttc ttgctgatgt ttttcgcgat cagcttcagc 3412741 tggcggtcat gctgcagcat ttctctggaa atattcagcg acagatcctc agaatcgacc 3412801 atgcccttca caaagctgaa gtggtccggt agcaggtctg cgcacttatt catgatcagc 3412861 acgccattgg aatacagctc caagcctttc tcatattcct tggaatagta gtcaaacggc 3412921 atgttttcag ggacgaatag aatcgcgttg tagcgaaccg ctccatccac gctgatatga 3412981 acgtgtgtca gcggtttatc aaacccgtaa tgcttttcag catagaattt ttcataatcc 3413041 tcatctgtca gctcgctttt gttttttctc cagatcggca ccatgctgtt gaccgtctgc 3413101 tcttcctgca cctcttcaaa ttcattttcg ctgccttcct tcggcttatt aatggttgta 3413161 tccattttga tcgggtagcg aatgaagtcg gagtacttct tgatgatcgc ttttaaacga 3413221 tattcctcta aaaactcgtc atagctgtca tcttctgtgt tctctttgat tttcaggata 3413281 atgtctgtac cgacagaatc cttttcacac ggctcaatcg tatagccgtc tgcacccgca 3413341 gactcccatt tataagcctc ttcgctgcca agcgctttac tgatgactgt cacgacatcg 3413401 gcaaccataa atgccgcgta aaaaccgaca ccgaactgcc cgataatgtc atgtccgtct 3413461 ttcagctcgt tttccttttt aaacgcgagg gaaccgcttt ttgcaattgt tccaagatgc 3413521 tgttcaagct catcctttgt cattccgatc cccgtatcag agatggttaa tgttctcgca 3413581 tctttgtcag ctgcgacctt tatgtagtaa ctgtctttat caaacgtaag cgcatcgtcc 3413641 gtaagcgctt tgtaatagat tttgtcaatc gcatcactcg aattggagat taactcgcgc 3413701 aggaaaattt ctttttgggt ataaatggag ttaatcatca tatccagcaa gcgtttagac 3413761 tctgctttaa actctttttt cgccactctt gatcgctcct ttaccattat gtaaaccctt 3413821 ttcagcatct atttatcaca taagatgaca attgtcaatt agattgatag atgcatatat 3413881 atgtaaattt aacattagtt ggatttgttt tcactctttt tctcactcat tctcataaaa 3413941 aagagaggct tcatcatcct ctcttttttt ctgtgtcatt ccaacggcca aactcccgct 3414001 tcatccatat atgcaccggg tagaaaaaca aaccgaacgg tatcaaaaac aaaagattat 3414061 gccatgaagc attcagaaat gcgcttgcag tcaccgggaa cgtaatctct tgcaataaaa 3414121 aagagatgac agtcagcaca acaaatgcag atggaatggt cacgatgcaa taaaacttga 3414181 gctccttctt atgctgtacc ttcaaacata caaacctccc aacaatttct aattcatctt 3414241 aacatatgct ggcctttctt ttctcgcatg tttatcactg cacatagcgg gaagacaaat 3414301 agaaaaagga ggtctcgtat catgggaaga cttgaaaaca aaacagcagt tatcacaggc 3414361 gccgcgacag gcattggtca agcgacggcg gaggtttttg ccaatgaagg cgcgcgtgtg 3414421 atcatcggag atatcaataa agatcaaatg gaagaaacag ttgacgcaat cagaaaaaac 3414481 ggaggacagg ccgaatcctt tcacctcgat gtgtcagatg aaaacagtgt gaaagcattt 3414541 gctgatcaaa tcaaggatgc atgcggaacg attgatattc tgtttaataa tgccggcgtt 3414601 gatcaggaag gcggaaaggt gcacgaatat ccggttgacc tgtttgaccg cattatcgcc 3414661 gtcgacctgc gcggcacatt cctttgcagc aaatatttga ttccgctcat gctcgaaaat 3414721 ggaggctcca tcatcaacac ctcctccatg tcaggccgtg ccgcggacct tgaccgctcc 3414781 ggctacaacg ccgcaaaagg cggtatcacc aacctgacaa aggcaatggc aatcgactac 3414841 gcacgaaacg gcatccgcgt caattccatt tcaccgggca cgatcgaaac accgctgatt 3414901 gacaaattag caggcacaaa agaacaggaa atgggcgaac aattccgcga agccaacaaa 3414961 tggatcacgc cgctcggacg tcttggccag cccaaagaaa tggcaacagt ggcactgttc 3415021 ctcgcatcag acgacagctc atacgtcaca ggagaagaca tcaccgcaga cggcggcatc 3415081 atggcgtaca catggcctgg gaagatgctg attgaggaga aatggaagga agaaacgaaa 3415141 taagagaggg agccccctct ctttttgtct tttaaagcaa tacaacctta tatttcttca 3415201 catccaaaaa ctgcaaaaac tccctcgcca gcacttcagg cggatgcgcc tttccttcat 3415261 ccagccgata caaaagcaac ccgataatca ttgcggatac ataatgggca taaagctttt 3415321 tctctgcgtg aatatcagtt tgctgatgca gataaaacga ttccagcgct ttgaacatat 3415381 caggtatcac atgaggaaca ccccattccc gattgagaaa atggacaatg ggcatgtttg 3415441 acaaagcaga aagcagaatg gcgagcgcct tctccgcttc ctttaaggaa aattcattcg 3415501 ggctggaggc aatcgtcagg tgatcaatga tctccgcaca tgatcgctgt atcatggttt 3415561 ggagcaattc ctccttattg gcatagtgat cataaaaggt tgcacggcgg atattgcttt 3415621 tacgcgtaat atctgaaatc gtgatgcccg cgtagtcttg tttctccgcc aatacatcca 3415681 gaaatgcctt ctgcagcgcc tctctcgttc gaaccacccg cctgtcgatt tgcttctcct 3415741 tctctcgctc tcctggcaca gcttttccaa acagccaata aaaccgcttt tgagaaacaa 3415801 gctcccatac cttctggctg atggcttcag gagacgcggc cgcatcctca ttcagccaat 3415861 acaggataat cgcgtacgtg tacaaggccc gataatgtcc ataaatgtcc cgttcaatcg 3415921 gcgttaaatt cacatggatc ggagccagca gcacatcctg ctgaaacaca tccttaaaaa 3415981 aacgatgaaa atgtcctctg ttcatcatca cagaaaaaaa ggaacgatgc tcatgaacaa 3416041 aggacagcgt cggatgcacc gtttgccgtt ttttgttcaa atgaagggta tccatatgac 3416101 tgaaggcgtc aaaaagcgct ttgcccagtc cttccttcat gtcttcgatc acatcctcaa 3416161 tgattgaaaa cttatcctca taataaaggt agagcgatcc gcggctcact ttggccttct 3416221 cagcgatttc tttcattgtg atgtgttgaa tatctctatc tttcaataaa gccagcagcg 3416281 cctctttcac ttgagcttcg gcagattccg gcacaaaaga cacctccaat cattagacag 3416341 atcttagata tatgtacggt aacgtataga tggttcaccg ttgtctttct tacagaaaag 3416401 gtaccacctt ataataggtc cgagaaaaga agaaagcaaa tgagggggat tttacaatgg 3416461 aacagcaagt aaaggacgac atccagcgtg tctttcagct tcagaaaaaa cagcaaaaag 3416521 ccttgcgcgc ttcaacagcg gaacagcgga gagaaaagct tcaacgcttt ttagattccg 3416581 tcatcgccca tgaagaagaa atcatcgaag cgatccgcaa agacgtccgc aaaccatatc 3416641 acgaagtcaa aaaagcggaa atcgaaggaa caaaaaaagc gattagagat aatatgaata 3416701 acctggaaca atggatggcg cctaaagaag tcggttcatc gttaagccct gacgcaaacg 3416761 gaattcttat gtacgagcct aaaggcgtca cactcatcct cggcccgtgg aactatccgt 3416821 ttatgctgac gatggcgccg cttgccgctt ctctcgcagc cggaaacagc gcgattgtga 3416881 agctgtccga tttcacgatg aacacgagca acattgctgc taaagtaata agagacgctt 3416941 ttgatgaaaa agaagtcgcg atttttgaag gagaggttga ggtggcaacc gaactacttg 3417001 atcagccgtt cgaccatatt ttcttcactg gaagcacaaa tgtcgggaaa attgtcatga 3417061 cagcggctgc caaacacttg gcatctgtca cacttgagct tggcggcaag agcccgacga 3417121 tcattgacag tgaatacgat ctgatggacg cagcgaaaaa gatcgccgtc gggaaattcg 3417181 taaacgccgg ccaaacctgc atcgcacctg attacctgtt cattaaaaaa gacgttcagg 3417241 acaggttcgc ggggatttta caaacagtcg tcaacgctgg atttatggag gatgatcata 3417301 ccccagaccg cagcaaattt acgcagatcg tcaatgaccg caacttcaac cgcgtcaaag 3417361 atctgttcga cgatgccatc gaaagagggg cggaagtggt gttcggcggc gtattcgatg 3417421 ccagcgaccg cacgatctcg ccaaccgttt tgaaaaacgt cacgcctgac atgaaaatca 3417481 tgcaggagga aatcttcgca tcgatcctgc caatgatgaa ctatgaagac atcgacgagg 3417541 tcatcgatta cgtaaatgac cgcgataaac cgcttgcact ttatgtgttc agcaaaaacc 3417601 aagatctgat tgacaacgtc cttcagcaca cgacatcagg aaatgccgcc atcaatgatg 3417661 tcgtcgtcca tttcagtgac gtcaacctgc cattcggcgg cgtcaacaca agcggaatcg 3417721 gctcctatca tggggtatac ggattcaaag agttttctca tgagaagggt gtatttattc 3417781 aggccgctga ataatcgcat gatcaaaagg cgcttcctta gaggagcgcc ttttattgta 3417841 actccttgac caaaagcaat tcatcacgga taggtatttt attatctgcc agtaaaggaa 3417901 tttcgggctt catctttctg gccgtctcga ctgcattcac aaatagtcga tccaaccggt 3417961 accctctctt ctgataaaac gctaatgcat gaatattatc attggttgtg atcagtttta 3418021 tttgtttgat atttctctct ctgcatgctt cctcggcttt ctctagcaga gctgttccga 3418081 tccctttatt ctcaatgaca ctatccagcg aaatgatttc acaggcatct tcttcaaata 3418141 tgtatgtaat aaggccaaca atctggttat catcgttgag cattccataa ccatctaatt 3418201 catcgcagtt ataaataccg ctagaaataa ccatttgcgg actgccccag tgtttttgaa 3418261 aaaacgcgga aacaagatct ttaggtacct ggcatgtcgg aataatattc atattttcct 3418321 ccttttagct gaacaaaaat aagagaatta acaacctatt ttatgtcatt aatcccctta 3418381 tctagtattt actagaactt ataacttgtc aaaagctgtc tgaataccaa ttgcgtggat 3418441 tgataaggat caaaatctga atcctgagat tggaagattt gctctggggt caatgtctct 3418501 gcgttctctg ataacgtttg aatcagactt tccaaatatc catttaactc tgatttggac 3418561 gattcatgta gggattgatg atttacagcg agttctctaa atctgttatc actgattaat 3418621 ttttttcgaa gagctgctag catcaagtca agccatgcag gctggccaaa tgtaatattt 3418681 aaagctaacg ttgcttgatc agatttggtg gagtgccata aacctcttgg caaatacagc 3418741 atggttcccg gtgttaaatt aacgatttct gcatctggca gatcctcttt tggcggatct 3418801 cctttccaat atgactgtaa atcatcagga tagtaaggag cctctgataa atcatagtgc 3418861 tgcattggat tgctcacatt ttcattcttg gcaagcttcc atgttttctc accttgaatt 3418921 tgaaaaatca agttggtgta ggcgtcaaaa tgggctttga atcccccgcc atttttcgcc 3418981 gcgtaaacaa tggctttgga agaagtaccc gcaggcagtc ttaattccgc tttgagtttt 3419041 tctatccacc ttctgacttg gggaataaat aggtcggtga aatcaaactc taatgcagcc 3419101 cctttttcat accactctaa agcctctgca ggtgacacaa gaaatctgtc tgtgatccct 3419161 tcagattctt caatcacagc atcaccaacg accatgactg gattattgta gatagccaat 3419221 acgttttcta gcgttctaac cttttcaaac cccggtatgc ttgtaaatct ctccacttct 3419281 cctctggcta ccaaaggttt tacaggccaa tattcttcta aaaactcact catcgttaca 3419341 ggactgatga tagactccaa aaccgattcg gttacagcac tcatattatc cctcccaaaa 3419401 aaagtaactt caccacaaag atataacatt tttttctaaa agtaaatatt gacagaatta 3419461 tcagaggatt ataatattta gttgtgcgtg atagcctatt tttttacaag gaaggaggga 3419521 aaaggatgaa aaaggcttat aagaaacctc gtctttttga actgcgccgt gctgtagcag 3419581 ctggcggcca ttaatctcat atagcatttg acatctagta ctctatttta ggagggatgc 3419641 tcaatgaaaa aagcttataa gaaacctcgc ctttttgaac tgcgccgtgc tgtagcagct 3419701 ggcggccatt aatctcatat agcatttgac atctagtact ctattttagg agggatgctc 3419761 aatgaaaaaa gcttataaga aacctcgcct ttttgaattg cgccgcgctg tagcagctgg 3419821 cggtcattaa tcttatccaa aacgattaac gtttgaggct atcacgccaa cttgataagg 3419881 aggatgctga agatgattac ggctgaagaa tgcagaacgt acaaagaatt tgttgatctt 3419941 taccaatcct atctttaccc cttgcttggc gccagactgt cccggatgta ttcccccaaa 3420001 aacaaagtca ttatcgatat gggcacaggt ccaggttatt taagcattca gttggctaaa 3420061 agaacaaatg cgcacgtgca tgctgtcgat attaacccgg ccatgcatga aatcgctcaa 3420121 gaagaagcta aaaaaagcgg agtaagcagc ctgatttcat ttgatttgga agatgtccac 3420181 catttatctt acgctgacca atatgctgac ttcatcgtct cctactcttg cctgcatcat 3420241 tgggaagacg ttgttaaagg acttaaagag tgctatagag ttctggctcc gggcggaaaa 3420301 attgtcattt tggatacatt taatccccaa ggaagccatt tagagattat gcgaaaacaa 3420361 atcaaagaac cggaatactt caggtttgta agagaggcat ttgaagaaag ttattccttt 3420421 gaagacattc accagtttgt tcaggatgcc ggcattccca attattcatt agaaaccttt 3420481 cactttttac cggaggattt tatagaaagc ttagatgagc tggaggatgc tcccctgtgg 3420541 gaacaaaatg atcaaagtac tgatcatgaa attgagtctg tcacatggat gttaacgata 3420601 gaaaaagaaa aggaaggtgc attgtaatga tcaatgaatc aactgtttta tccaaaaatc 3420661 cagaaatgcc atcaagaaaa tatttgaaaa gcattattat agagccgggc atcactttaa 3420721 atgaaatggc atcagatatt tataaccata tcgacggcaa ggtcagcata catgatattt 3420781 gctcaaaaat cgtcaatgaa tatgatgttg attatcaaac ctgcttagaa gattgtatgg 3420841 agctgtttga gttgcttatt gatcatgaag caatcaaagt taagcagggg gcatgagaat 3420901 tggaaaaaca aaaagtgctt gctttaccag acgatgtaca tgagctgagt acacaccgtt 3420961 ctaaatcaat cgtaaattac atcatcactc tgcttgcctt tgccaaaaaa caaggattga 3421021 ctcatcaaga tattgtaagc tggattcacg agcaatatga ggaaagagga tattatgatg 3421081 agtggagaca cattaacagc caacaaccag ttggatcatt tgtggaactc tttataaaag 3421141 gaagacgttt actttatgac aaaattgaat tgtttgaaac agaagataaa tatgtcgtaa 3421201 atacccacac ttggtatgaa aaagaaccta gtgaggcctt tttttatttt gaaattgatc 3421261 ccgaagaatt ttctgcgtac gcttccattc tcgcaatcga aaacgcaaaa cgtctcggaa 3421321 ttaaaatcga tattgtaaaa gaaacagatg tagagacagc ttatatctat aaacatcaat 3421381 aacgctattg ggagggagac atatgtgcgg gctcgcgggt attataaatc tggctgctcc 3421441 ccgttctcag gaatgtacct ttcatatatt gaaaggcatg gcagatgcca tcagctatag 3421501 gggaccggat gatgaacaat atcatattga ttccaaagtc ggctttgcat ttcggcgatt 3421561 gtccattctt gaccttgtaa atggacagca gcccttttta aatgaggatg gatcaatcgt 3421621 cgttatggta aatggagaaa tttataacta taaagaactg aaggcttctt tacacaatca 3421681 tatgtttaaa acgacatctg attgtgaagt aattgttcat ttatatgaag aaaaagggat 3421741 tggatttgta gacgacatca tcggaatgtt ttcaatagcc atttgggaca aaaataaaaa 3421801 caaagtattt ttagttcgtg accgctttgg gattaaaccg cttttttaca cagagctaaa 3421861 acacgagctt atatttgcct ctgaaataaa atccctattt tctcatcctc actgtccccg 3421921 ccaatttaat tggaaagaag cactctcaga catttggcta agcggggaag cagccagtaa 3421981 tcataaagaa accacttcct tttttgtaaa catccaaaat ctcgatgctg gccattatct 3422041 cgaaattaat ttgacaacaa atgaacgaaa aacagcaagc tattggtctt tacaggatat 3422101 tttgctcagg caaggctatc gtgagaatct ccatcccgat gacctgattg aaggatatag 3422161 agaactgctg gcagattcag tccatagatg tttacaaagc gacgttgaag tcgggttgtt 3422221 tcttagcggt ggcattgatt cagctgcagt cgcacatttt gctgcagaaa aacaggatct 3422281 ccatacgttt acagtattaa gccaaagtac atttacaaat gaagatgcaa aatatgccca 3422341 ttggctggct aaagatttac accttccaaa tcatcaggtt ctctatcaat tagggaacga 3422401 tgagttatta caaccagagt catataaaca tttgttatgg atctgtgaaa caccgttttg 3422461 cggaccggaa caattatata agtttcattt acataagtat gccaaagcga taaggccaaa 3422521 cctgaaagtc atgctgaccg gccagggcag cgacgaattt aacggcggtt acagcacgac 3422581 actttcacca gccgagaacc caagttggga aggatttatt gaatcggtca atacgatgga 3422641 gatgaaccgg ctgcatcggc tgcagggaaa tatctttaga gtgtgggagg agcattttgg 3422701 actttctcct ataaaccttt cttatttaaa gagcaatgat tccagccaag cagatccttg 3422761 gcaatcgtat gtcctgacaa aataccgtga tctgcaaatg tataattgct ggcatgaaga 3422821 tcggatcgcc gcggctaatc atatcgaaaa ccgtgtaccg ttcttggacc atcggcttgt 3422881 tgaatgggtt tgcggaatac ctgatggact ccgtaaagac ttgttatggg ataagtcggt 3422941 attgcgaaaa tcattaacaa atgagctgca tacaagctat acccaccggc caaaggttcc 3423001 ttttttctat ggtaaggacg tgagatatac acataaaatg atgtttcatc ttctgaagaa 3423061 aaacaattat cagcttatag aggaggcctt ctctcacagc gatgcctcca gcataataca 3423121 ggttgaacac attcatgcca tcatgacata tttggaggat gatcctgagt ttacaaattt 3423181 tgaattttta ttaagactgg tgaacatggg acttttatca aaaatgacta aagaaacccc 3423241 ttctgttcaa ttagacataa ccagccattt agaatcgata acaataaaag actggcactc 3423301 acaggaaggt gatattgcca gtcgtttaaa tatctcagcc aataagtgtg aaggacaaga 3423361 tattttggcg ctaaaccctg gcgtcactct gttaaggccg gaaagcgata gtgagcattg 3423421 catctacatt gcggaagaag gatttattca gtttattgtt tcggaggaag acgtcggagc 3423481 ttggctgcat attctctgcg atattaatgg aaaagacaca cttcatacga ttttagacag 3423541 acatggtgtc agccttgaag aagtggccaa atatattcaa gaagccatcg aacacaatat 3423601 cattttgatc aaacaaaaaa atctgccaga aggagcatat agatgagcat cttttattcg 3423661 ttttccgcac ttaggggatt agcaatgggg attttttcgc ctatttggat tctttatctg 3423721 atatctaaag attatgattt ccttcagatt ggattaatgg gagcggtact tgaaattgct 3423781 aagcttatat ttgaagttcc ttccggcgtt tttgctgatc gttatggaat taaaatttca 3423841 attgccagtt cattcttttt ctccatcctt acatgggcct tcttcccttt tatcgattca 3423901 gctgctattt gcatactggc tatgatcata tgggctttat cagattcctt aatttccggt 3423961 tcttttgaaa cttggatgag ccgtgtcgca ggggaagatc gattcggcaa agaaatgatg 3424021 aaaaacacac aattgctaat cactttttta attattggaa gtattgccag cgggtatttg 3424081 tattcattaa atatctattt tcctttcctg ctcgttatgg tgatctactt attactattt 3424141 atttggatgt ctgtatttat taaagtccct tctgtttccg aaacaaatca tggggatcag 3424201 aaccaacatg attcgataaa gattatcaaa gaaagtttaa aaattatctt taacaaaaaa 3424261 agggttcttt taatcgtcat agccggtttc tttacagcca cagcctatga cacaatttcc 3424321 cgttactggc agcctttttt gagtgattta ggcttttcag aaaagtcact gggatatatt 3424381 tttgccctag gagggtttac cgctctcgtt cttttgacat taaccatcag gttcgaaaag 3424441 aagatcgaaa aaaatccata tctcgcttta acctcattgg attccatggg catggtcatg 3424501 acttttctat tgtctagagc attcaggccg ctgggcattc catgtacagc gtttttgctt 3424561 gcaattgaag atattcatca tccgatcgta acaagttact taaataagtt tttccccgat 3424621 tcatacaaga acacactttt ctcgttaaac tcaggggtag gagcaattgg agaaattctt 3424681 tccggtgtca ttttcggcat catttccgca gcctttgggc tctctgccat gtttgttgtt 3424741 gtagctgtat ttctattaat ccctattatc ctttatacga tagtgcctaa gattaaagac 3424801 aatgatatga aagttcagat tgaaaaatcc cagcaagtgt aaatgttttg tatcacagta 3424861 agaagacctt cttattaaaa gaaggtcttc tgctattcta ttcagttatt tcccaaaagc 3424921 catcagcttc gtataacttc caatataaag tgttccgtcc tcagcgagct gaggagaaga 3424981 cacgacgttg ctgtcggttt gatagctcca taattcattg ccgtttgcgt ctgccgcata 3425041 aaccttcata tcatctgacc cgaaataaac cgttcccttc gcgtcaatca gcggcgccgt 3425101 tctgacaggg ccgtctgtgt agaatgacca gttcatatcc ccgtttttgc tgatggaaaa 3425161 cagctcgccg cttcctgagc cgatgtagat attgccatta tgatcaatcg caggagatga 3425221 gctggagaac ccgtttagcg ggaatgtcca tttcaaactg cctgttgatg tataagcata 3425281 cagctgtcca tcttggttgc cggcataaat gtttccgtcc ttatcaatca ccggatatcc 3425341 tttaaacgca tttgacgtcg ttctggacca tttcacctgt ccggttccgg agttgatcgc 3425401 ataaaacacg taattatatg tgccgacata cacggtgccg tttttggcaa gcaccggcac 3425461 agagctgacg accccatttg ttttcaactt ccagcgctct gtccaggttg attttgacgt 3425521 cggtttgatc gcgtgaacat aattatcaag tgttgagaaa tacaacgtcc cgtctgaacc 3425581 gatcaccgtt tcagagcttg gcccgccgct taacggaacc gttgttaaaa tttctcccgt 3425641 ttctttgtca ataaaataaa tctttttgtc ataggatgcc aaatagataa cgccgttggt 3425701 cccaagtaca ggagattgcg tatatgtttt tccaagattg cccgtcaccc atttgactga 3425761 gccgtctgga ttaaaggctt tcatttcccc gtctctggaa tgaagatata ctgtgccgtc 3425821 tccgtcaatc acagcccccg ctccattttg cggagtcgtt ctgatgtcgt tttgccattt 3425881 cagcgtcccg tctgtatttc cggcgaaccg gctttcgcgt gaccagttaa acatggcagg 3425941 cgccatcgct tgtacatcat atcttcctgg caaaaagcca gatgctccat tattttgaga 3426001 aaacaccgtt tccgccgcat aagcagctgt cggctgaagc actttggcag cgggcacatc 3426061 agaaacagcg ccggccgaaa cagccgccgc caccgcagct cccgcaatca aagctttcat 3426121 acgaaatgac ttgaccatca ttgagacccc cattatatgt aacttctaat ttgtgaccat 3426181 cataacatat tcatccattt tataaatcta tttcacaaaa acatcacaaa ctagaaaact 3426241 atgtaagagt attcacggac gttttttcag cacccgatcg aaatgcagcc acaaaccaaa 3426301 tgacgttgac agcagccgca gcgagactaa ctcccaaaac aaagatcacc tcagaaagca 3426361 gatggtcact aaagaaacta aacatcaaga taaaaccggc cgaagacaaa tgaatcaaaa 3426421 gcccgaagcc gcaaagcacc gccatgacat acctcattgc atcgactccg agcatataaa 3426481 cgagaaatgg aatgaaatac aagacaagga tcataccgac agctgaccac atgccagctg 3426541 aattaaactg attggccgcc gctcccgttc cggccagcgg cgaaagtgaa gccgccacaa 3426601 tcacggcgca aaaaagaaac gcagaaatgg ttgtcatgat cgccacgcta tttttttttg 3426661 acatcaaact cctcctttaa tagaaatatt aacctttttt attataagta agttgaatgt 3426721 tatattcatt atatttttaa aaaattccag aatacataca caaatgctat gcttctttct 3426781 agtatattta tatagtaaaa aacaaaggat aaaagactca tttttctgta atatcaggat 3426841 tttatcacca taccatattg catgtacatg tttttcaaag tatactattc cagattaatt 3426901 cagaggagag agaaaaatac atggaaaaac cagcaggatt ttggattcgt tttttagctt 3426961 attttattga cggcattatt gtatctgttc ctagttatat tattctattt attatcaatt 3427021 ctgtgtttgt agctggggct gtggcaacaa acccttacat gacggaagaa gagtatttag 3427081 tgaaatacat gacgcttgca tttttgccta ctatgctgat catgatcgtc atcagcgtgt 3427141 tatattacgg gctgctcaca gcttctaaaa tgcaaggcac acttggcaaa aaaattcttg 3427201 gcctgaaagt ggtcaatgaa caaggtgaac gggtttctgt cggacaggga attggccgtt 3427261 actttgccta tatcttatct ggaatcatct tttatatcgg gtttatcatg atcgcctttg 3427321 gagagaaaaa aggcctgcat gacatcattt gcaaaacacg tgtcgtgtat aaataataga 3427381 aaaaagtcta gacgccaata ggcatctaga cttttgtttt ctttgcaata ggctgccacg 3427441 acagatacgt agcgcttctc cacaaccact caaacggccc catccgaaag acacgaagcc 3427501 aaaggtggct gaagaccatt tgaacggcac aaacagcaat tgtaatgagc acaccggcag 3427561 cagggtacac ttttccatac aggcccaagc cgtaatgata aaaaatccaa gtacacacaa 3427621 tagactgcat caaataattg gtaaatgcca tcctcccaac agcggagaat gattgcagca 3427681 ctgttctcac tcttgtttta tgataaagat agacaaccgt tgtaacatag aaaaacatga 3427741 ggaaaggcgc gccaatcagc aaacatattt ctttatccgt tacactgtac agcacctggg 3427801 cgccgatgcc gatgacaagc ccagccatcc ataatcgttt taatcctttg cgatgctttt 3427861 ccggttcatg caaataccgt gattttgctg ccgcagctcc cagcaaaaac atgctgaaat 3427921 atggaatgga tgcaaagaag tagttgagcg gattatacgt aagcatgcca ttcgaagaca 3427981 tgtaaacaag acggtcgtgg atccgctgtt ctgcaatatc cttcaggctg ccgcttccat 3428041 aaacatgaat cgcttgtttt gcctgctgtg ttaccgcttg tacccattcc tgtccgtttg 3428101 attgatcaaa acttgtcaac atgaacggaa tggaaaacag aagatacaaa gagaccgccc 3428161 atatcagcag tgttttcggc tttgcttttc gaaacaagag caggacaaat ccgagcaggg 3428221 catattctgt taaaatatcc ccgtcccata tcaaaaaggc atgaatcgtt ccaaacaaga 3428281 gaagcgccat taaccttctc acatataacg gaacaaaccg tttccctttg ttttctgctc 3428341 tctccatcat gacaaccatg ccaaatccaa ataaaaagga aaacaataaa atacattttg 3428401 tttgaatgaa gaatttcagt atgtctgcgg cggcaaaatc agcttcagac cacttatcca 3428461 tgaaaaaatt ctcttttcca agcatagaca aatacatatc cggataactg aaatgtgcca 3428521 gattgacaaa taagatgccg aaaatcgcca ttcctctcag cacatcaagc acaccgatcc 3428581 gctcatttgt taaagtcggc tgtaatgaag acatagccat cacgctcctt ttttctgtac 3428641 cttaagggta ggaaaaaatg aagcgcggta acatcgattt aggtgtcagg ccggcatgaa 3428701 aaccttacaa tcttgtcatc tttatggttt catcaccttt aaatctaatg cttcgatatt 3428761 ctgcaaaatg cgatcaaagc gcaaagcctg aggctcacat gggaagatgt ggccttcata 3428821 cgggtcgcct aacgtccgga aaaacggttc aaataaacca ggaaccaata cgcccaccat 3428881 ctttgtatag tgagaatcaa ggcgatagga gtgaacggta tttgcaggga catgcaggaa 3428941 atctcccgga ttcagctgaa tttcctggcc atctgtccac atcgtcatct ggccttcaag 3429001 gcaataaaat gtttctgtat gatattcatg gtagtgatca acgattcggt cacctttagg 3429061 gccttcagat gatacgacga taaactggcc atctgtattt ttttgtgcag ccacaatgcg 3429121 gtgaagctga tctccagtca acagacgatc tccttctcca gattcaagaa cgtatggaac 3429181 cgctccatct ggcagctctg taagttccgc taatttggcc gaacatgcag gctttgcttc 3429241 atctagaaat acaatgtccg ctacagcggc tgcttctgca aatcgctcgt ttgagacttc 3429301 ttcgcttgcg tacggcggat gttcagcgtg atcatacgga ttcccaataa cggaatacaa 3429361 gtgcgctacg tttcctttca tcgtgtaaga caccagtctt gttctgtggc tctgcatccg 3429421 gtagctgtgc ggtgttcccg ccggaatgtt ggcataatca cctgatatta ataaatagcg 3429481 ttcaccatca agtgtcagtt ccagtttccc gtccaaaacg agaattcctt catgtgtgtc 3429541 cttgtggacg tgaagcggaa aggcatctcc ttttcccccg gaaagaagca cgatctcaaa 3429601 caaatcacct gtgctcctcc cattcgccat caccgtggca acctgtctgc cgaacagata 3429661 gcgctcgcct tctccgctcc ggagcaaata aggcattttt tctttaggca atgaatgtgt 3429721 acataatgtt ttcatattat cgcttcctcc aatttagacc agtctatata ttatcattca 3429781 tttgtctaga ccgttctata taattgtagg agaaaggata acaaaatgct accctttttt 3429841 tctcaccagc actggtattt gttcggcaat gagaagaaga ggcgttttgt ctttattcgt 3429901 taacgaaagc atgatgccgc cctcaatcat cgaattaatc agcgttccaa gctgatttgc 3429961 ttcttcttct gcaaatccgt tttccattaa ttttctggca aaaaccgctt cccagctttt 3430021 aaacaccttc atgcaaaccg tccgcagcgg ttcactgatt aacgctgtct cactcgccag 3430081 caaaccgact ggaatacctt taatgctttc tgtgttgtca aattggctgg ctgttttttt 3430141 gataaaaagc tgaatcgctt caacaggatc agaggattca tccatgcttt gctgtatcag 3430201 atgttcaacg atcttacctg tatatgtaac cgcttcaatt gctagttctt ctttgccatt 3430261 cggaaaaaag tgataaagcg atccttttgg agcaccgctt tcttttacaa tctggttcaa 3430321 acctgtcgcg tgatatcctt gcagctggaa cagacgtgac gccgtgtgaa ggattttttc 3430381 acgtgaatct cctctgctag tcattaaaac attccctcct aggtatggta gagcgactta 3430441 tataatataa aaaagaaccc tgtgattgtc aaaaggggta agacccttcc ggatggggta 3430501 atgtacaaaa acagcgtcta ggagggatct ctcaatgaca atcgatcatt cagtcacaaa 3430561 tacagagcag cttgaacaac agaaccccgc cataaaaaca aagctcaaac tgaaaaagct 3430621 taaggatcag gtgatcgtca ttaccggcgc ttcaagcggt atcggacttg tcacggcgag 3430681 aatggcagct gaaaaaggcg caaaggtcgt ggcagcagcg cgaaatgaag aggcgctgaa 3430741 ggagctcact gatgaactta aggaaaaagg gcacgacgcc atatgggtaa aggcggatgt 3430801 cggaaaagaa gaggacgtca accgcatcgc agaaaccgcg atcagcacat tcggccgctt 3430861 tgatacatgg gtcaacaatg cggccgtctc gactttcgga cacgccatgg acgtcaccgt 3430921 cgaagacatg aagcgcatgt tcgacacaaa tttctgggga cctgtttacg gaacaagagc 3430981 ggctgtcaaa cactacaccg gcagaggtgt gccgggcgca ctcattaatg taggaagcct 3431041 gttcggagac aggggaacgg tcattcaatc cacatatgca tctgccaaat ttgcgcttca 3431101 cggctggacg gaaagcatcc gaatggagct tgaaaaggaa caggcgcccg tctcggtaac 3431161 gctcatccac ccgggcagaa ttgacacacc atataacgag catgcgcaca gctacctcga 3431221 caaacagccg gctcattacc gctccatgat ctatccgccg gaagcggtcg ccgaagcgat 3431281 cctgtttgcc gccgaacacc ctaagcgcga catgtacatc ggctcacagg ccaaagccat 3431341 cgccatgctg ggcgcgcttt ttcctcgtct gaccgacaga ctgatggaaa aaatcatgta 3431401 tcacagccag catgccgaaa gaccgtccaa tccgagagaa gaaagcgctc tttatgatgc 3431461 tggctgcggt atgcatgaca gaggcacaaa taaaggatgg atgaggtcaa gaagctacta 3431521 cacaaaagcg acgaagcgcc caattgtatc ggcggctgtt gttgccggac tagtggcttg 3431581 ggctgccgcc aaacgatgca gataatctct gaccataaga aaaacccatg ctgttccagc 3431641 gaaccatggg tttttcagct gttaatcgat aaaagccttg ttcatacgct gcagcagctc 3431701 gccgaacatc tctttttcct gtgttgacca ttctttcagc atctgttcat aacgttcaag 3431761 gcgcttttgc tgatcggctt ttaatagttg tttgccgagt tttgtaatgg taaacaggct 3431821 gactctccca tcagacgggt ctgagaaacg atagatgagc tcctttgcct ctaatgcagc 3431881 tgcttgtctt gaaagagtag aaatatcaag cttaaacgat tcagccaatt ccttaacacg 3431941 agcaggccca aactcatcca attgtctcag taataagtac gaagatctct ccaaattccc 3432001 tgttcttttc tccgattgat ccagataaac agctctcctg ataaaagtcg tcagctcata 3432061 ttcaattaat tcaactggat tttgattttg caatcgctct cgctccctat tccaatctcc 3432121 ggcattgaca acatcatata tacttgtata atacaaatgt acattaactg aataaataca 3432181 agtcgttata tgactaaatc aattattata cttgtatagt acaatcatat aaaaagaaag 3432241 taaagcgatt cctcagaacc atcctagaag caagcaccag aaaggaggaa gctgttctga 3432301 ttggagagca gcacttgatg tgaaagtcat acgaattatt ttgcaagtgt tgatattata 3432361 tgtatttttt atgatcgggg aagccattca gcatctgttt catttacccg tgtcaggaag 3432421 catcgttgga ttggtattgc ttctgatctg cttgggcctc cgtattgttc ccgtctccat 3432481 cattgaagac ggagcagggt ttttattatc cttccttcca ttgttgttca tcccggcaat 3432541 gacaggagtg ataaactatc cgtctctcat ttcattcaat ggcctgatgc tgctgattac 3432601 agtcgttctc agcaccatcg tcacgatcat tgcggctgga ttcgccagcc agctattaga 3432661 gaaaaaagca aaaaaacggg aggagaaaga gaaatgcagc aagcatgtat cgcgatcatt 3432721 ataattcttt taacagttgc cgcttattta gcgatggtca aactctataa gcgattcccg 3432781 cttccatttc tgatccctgt tctgacaacg acaattttga ttgtagcggc tttgatgatg 3432841 tttcatgttt cctatgaagg ctatatgatc ggggggaaat ggatcaattc tttgcttggg 3432901 ccggctgttg tggcgctggc ctatccgctt tataagcaat ggcatatcat tgtcaaacat 3432961 tgtgttccca ttttaggcgg cgtcctggtc ggcttatgca tgggaatgat cagcgggctg 3433021 atcttcgcag aagcattcgg gattgatcat gatctcttat tatccattct gccaaaatcg 3433081 atcacaaccc ctgtcgctat tcagatcgcc gccggtcttg gcggcgtccc ttccatgaca 3433141 gtcgtatttg tcatgattgc gggcttttca ggcgtcatcc tcgggccgct tttcctaaaa 3433201 tggcttcgca tacgcagctc cctaggacaa ggcattgcat taggcagcgc ctcccatgca 3433261 ctgggtacct ccaaagcgtt ggaatatggg gaattggccg tatccatgag ttccgtctcc 3433321 atgacgcttt gtgcggtgct cggctcattc ttcggcccgc tcgtcgtctg gctgtttcat 3433381 atttaacaaa gaaagactgc cccgggggag ggcagtcttt ttcgtttaag aagcaaaaaa 3433441 atcaatcaac ggctgaaagt ccttagataa atcaacgtca ttcggttctg cttgaagcag 3433501 gcggtcaatc atacgctcca gctcctcaac atcattctta tccgtatatt caatgaagtt 3433561 taagctttca agccaatccc gatatgaatg tttggctttg ccatagctgt ttccaaagac 3433621 aaggcaaggt gttttggtga taatcgagaa aatcatcgcg tgaaggcggt cggtaatcac 3433681 caatttactg gagccgatgc ggtccagcat ctccataaaa tgcttttcac gatcagcgta 3433741 atcgatggtg tctaccgtat ccagcaccgt atcggtacgc tctgtgtaag ttgttttttc 3433801 tgcccattgc ttcatctgtg aaataaaatc ttcgtcagtc actttctcct tatccgctct 3433861 taaaataaag agaacgccgt cccgctcgag ctctcgcggc acaatatcca aggaaagcac 3433921 catgtccggt gtaaagatca cattggagtt gaaggtctct ttcacaacat ccagtgtttg 3433981 cgtctcacgc gcagcaatcg ttaagtttgt attttgatgg tacgcatcct gtgttttttt 3434041 cttttccttc tgtccttcct ctgtatcctc aaaataaacg gattgtggca gagaaattga 3434101 tttgtagtct ttaaacgccg aaaagacctt tcttctgtct tcctcaatat cgagataaag 3434161 gtttcctaaa ttccctccgc ctgtaaagca gacaatatcg tcttcacgaa tgatctcctt 3434221 caccagttca atgccctcat ccgtcgcata atccataatc tcaatgtatt cataatacgg 3434281 aaaatgattt ttgataaatt tctcttccgc atacgcaatc gcttggtcgc caatgtttgt 3434341 gtagctaggg gaaccaaaca aaaatacttt tcgtttatca tttaacagag cttccggctc 3434401 cacatttggc gcaatgcctt ttactagttt tttgcctttg atttcttgta cagtcatatc 3434461 tgcgtcctcc ttctgggatg aattcctcat tgtgtgttaa ctgtctctac ccaaaaagaa 3434521 ggatggctat gcattggcat gtgcatcggc tatatcagaa acatcgtttt cgccaatttg 3434581 atagacgctg caatgtcccg cgccgttctt tccatatatt ccgcggcatg ttcaaacgcg 3434641 tcttctagtg gcacggctcc ggggacgatg ctgaaaagcg catcgattcc gtgttgatag 3434701 acggcattac tgtctcggga aattgatccc gcaatgccga taacgggcac atcgtatgat 3434761 ttagcggcct tggccacccc gatcggtgtt tttccatgaa ccgtttggct gtcgattcgt 3434821 ccctcgccgg taatcacaag gtctgcatcc tgaacgatac tttcaaaatc aaccgcttca 3434881 aggacaatat caatgcctct tttcaggtca gcctgaagat aagttagcag gctccatcca 3434941 agaccgcccg ctgcaccggc gccctctgta tctcggaagg ttgatccgag cgctttttct 3435001 gccatatcag cgaaatggct tacgttctgg tctagtacat ccaacatgtc ggccgtcgcg 3435061 cctttttgcg gcccgaaaac agccgtagca ccctttggtc ctgttaacgg attgtccacg 3435121 tcacaggcaa cttccagttt gacattccgc aatctggaat caagcccgct cacatctatt 3435181 gatgcaagct gagataacgc gccgccccct gggccaatct cgctgcctga gttatcaaga 3435241 agccttccgc ccaatgcctg aatcatcccg gctcccccgt cgttcgtggc gcttccgccg 3435301 attccgatga tcaatcgctc cgctcccgca tcaagagctg ctccgattaa ttctcccgtt 3435361 ccccttgttg tagtgatgag cggatttcgc ttatctacag gcaccagatg cagccctgaa 3435421 gcagcagcca tttcaatcac agctgttctc ccatctccca tcatgccaaa gaaagctctc 3435481 accggttccc ccagcggccc tgtgacaact tgctctatga tccttccatt ggtcgcatcg 3435541 accagagatt gaacggttcc ctcgccgcca tccgccaccg gcaattttct gtaatcagca 3435601 cccggaaaga ccgatttgaa acctctttct atcgcttcgg ctgcctccag agctgataag 3435661 ctttccttaa aagaatcagg tgcaatgatg attttcatcc aaatcgcctc tttcaaaaca 3435721 tgattcactt aacctattga tctccaatgt accataattg atctggaaat acataccatg 3435781 caatatggta aaaatttaaa taaaaattag aaatgaaagt gtttgcataa aagaaatatt 3435841 cacgttatca tacttgtata caagtatact ccttgagtga ggaaggtgag tgtatgctag 3435901 actccaaaga cctgttgtat cccgcaaaat ggctctcaaa agcgtcaacc ggagttcgtg 3435961 tcgcatacga gctgagaatg cggatcgttt caggtctgat tgaaagcggt accattttat 3436021 cagaaaatac aatcgccgcc gagttttcag taagccgttc gccggttcgc gaagcgctaa 3436081 aaatactcgc atccgaaaaa atcatccgct tagaacgaat gggagcggtc gtaattggtt 3436141 taactgagaa gaaaatcgcg gaaatttatg atgtgcggtt actattagaa acatttgtct 3436201 ttgaacggct tgtcaaaata gacattgagc ctttagttaa ggatctcagc aaaattcttg 3436261 aaatgatgaa agtctcaatc aaatatgagg atgctgacga attttcattt caagatgtgc 3436321 tgttccatga aacgattatc cgagcgattg atcattcata cattcagatg atctggaaca 3436381 atctaaaacc cgtcatggaa agctttattc ttttatcgat gcgggtacgg ttaaaggaaa 3436441 agtatgaaga cttcacaagg attttagata accacgagct ttatattcaa gccatcaaaa 3436501 caaaggatag ggcgctgatg attcagtctc ttcaccaaaa ctttgatgat gtgcaggata 3436561 aggtagaaga cctatggctc tcacaacaaa tgctggcaaa aggagctgaa tacaacaatg 3436621 actagttata tgttaggaat cgatatcggc acgacaagca caaaagctgt gctgttcagt 3436681 gaaaacggag atgtggtaca gaaagaaagc atcggctacc cgctctatac accggacatc 3436741 tcaacagctg aacaaaatcc ggaagagatt tttcaggcag tcatccatac aacagcgaga 3436801 attacaaaac agcatcccga aaaacggatc tctttcattt cgttcagcag cgccatgcac 3436861 agcgtcattg caatcgacga aaatgacaag ccgctgacgc catgcattac atgggccgac 3436921 aacagaagtg aaggctgggc gcataagatc aaagaggaat tgaacggaca tgaggtgtac 3436981 aaacggacgg gaacaccgat tcatccgatg gcaccgttaa gtaaaattgc ctggatcacg 3437041 aatgaaagaa aagaaatcgc ttccaaggca aaaaaatata tcggcatcaa agaatacatt 3437101 tttaaacagc tgttcaatga gtatgtcatc gattactcat tggcatcagc gacaggcatg 3437161 atgaacctga agggcttgga ttgggacgaa gaggcactgc gcatcgcagg catcacgccg 3437221 gatcacttat ccaaactcgt gccgacaacc gagatctttc agcactgcag cccggaaata 3437281 gcgatccaaa tgggaatcga tccggaaacg ccttttgtca tcggcgccag cgacggcgtg 3437341 ctgtccaacc tcggcgtcaa cgccattaaa aagggtgaaa tcgccgtcac catcggtaca 3437401 agcggtgcca ttcggacgat tattgacaag ccgcaaaccg atgaaaaagg gagaattttt 3437461 tgctatgcct tgacggacaa gcattgggtt attgggggac ctgtgaacaa tgggggcatc 3437521 gtccttcgct ggatcagaga cgagtttgcc tcctccgaaa tcgaaacagc gacacggctg 3437581 ggcattgatc catatgacgt gctgacgaaa attgcccaac gcgtcagacc cggttctgac 3437641 ggtctgctgt tccacccata tctcgccgga gaacgcgctc cgttgtggaa tccggatgta 3437701 cgcggctcat ttttcggctt gaccatgtcg cataagaaag agcatatgat acgcgcggca 3437761 ttggaaggcg tcatttacaa cctgtacacg gtgttcttgg cgttaactga atgcatggat 3437821 ggcccggtaa cccgcatcca agcgacaggg ggttttgcaa ggtcggaggt ttggcgccaa 3437881 atgatgtcgg atatcttcga atcagaggtt gtcgttccgg aaagctacga aagctcatgt 3437941 ctcggcgcct gcattttagg cctgtatgca acaggaaaaa tcgattcttt cgacgccgtg 3438001 tccgatatga tcggcagcac atacagacat acgccgatcg aagactcagc caaggaatac 3438061 agaacattaa tgccgatttt catcaatcta tcaagattat tagaaaatca atatacacaa 3438121 attgcagatt atcagagggg cttaatcaca cacaaatagt acatgacatg aaggggaggg 3438181 cattaccatg ccgttaatca tcgttgcact tgggatctta gcattactat ttctgattat 3438241 gggcttaaaa ttaaacacat ttatttccct gctggtcgta tcgttcggcg tggcactggc 3438301 actcgggatg ccgttcgata aagttgtcag ctccatcgaa gcaggaatag gggggactct 3438361 tggccacatc gcgctcatct tcggactcgg tgcgatgctg ggcaaactga tcgcggattc 3438421 aggaggcgca cagcgcattg cgatgacgct cgtcaacaaa ttcggtgaga aaaatattca 3438481 atgggccgtt gtcattgcct cattcattat tgggattgcg ttattttttg aagtaggact 3438541 ggttctatta attccgattg tctttgcgat ttcaagagaa ttgaagattt ctattttatt 3438601 tctcggaatc ccgatggtcg cggcactatc cgtcacacac ggtttcctgc cgccgcaccc 3438661 gggacctacg gcgatcgccg gtgagtatgg cgcaaacatt ggagaagtgc tgctgtacgg 3438721 ctttatcgtt gctgttccga cagtgctcat tgcagggccg ttatttacaa agttcgcgaa 3438781 aaaaatcgtt cctgcatcat ttgcgaaaaa cggcaatatt gcatcactcg gcacacaaaa 3438841 aacatttaac cttgaagaaa cacccggctt tggaatcagt gtctttactg caatgctccc 3438901 gattatcatc atgtcggtcg cgaccattat cgacctgctt caagaaacaa tcgggtttgc 3438961 agataacgga gttttagctt ttatcagatt gattggaaac gcatcgactg ctatgattat 3439021 ttcgttattg gtcgcagtct atacaatggg catcaagcgc aacattccag tcaaaaccgt 3439081 gatggattct tgttcaactg ccatttcaca aatcggcatg atgcttttga tcatcggagg 3439141 aggcggcgcc ttcaaacaag tgctgatcaa cggcggtgtc ggcgattacg tagcagactt 3439201 attcaaagga acggcattat cgccaatcat tctggcatgg ctcatcgcag cgatcctgcg 3439261 catttctcta ggatcggcga ctgttgccgc actaagcaca acaggtctgg tcattccgtt 3439321 attgggccat tctgatgtta acctggcgtt agtcgtactc gcaacaggag ccggaagtgt 3439381 catcgcttca cacgtcaatg acgccggctt ctggatgttc aaggaatact tcggattaag 3439441 catgaaagaa acattcgcca catggacatt gctggaaacc attatttccg ttgctggact 3439501 gggattcatt ttattgttaa gtttagttgt atgaaattaa gaaggagctg taacacatgt 3439561 tcaattcgat tggtgtcata ggcttaggcg taatgggaag caacatcgcc ttaaacatgg 3439621 caaataaagg cgaaaacgtc gctgtctata attacaccag agatttaacg gaccagctta 3439681 tccaaaagct ggatggacaa tctctcagcc cgtattacga gcttgaggac tttgttcaat 3439741 cgttagaaaa accaagaaaa atctttttga tggtcacagc gggaaaaccc gtagattccg 3439801 tcatccaatc attaaagcct ttgcttgaag aaggcgacgt catcatggac ggaggaaact 3439861 cccactatga agacacagaa agaagatatg acgagctgaa ggaaaaaggg atcggctacc 3439921 tgggagtcgg catttccggc ggtgaagtcg gtgcgttaac agggccttcc atcatgccgg 3439981 gcggagatcg cgacgtctat gagaaagccg ctcctatcct gacgaaaatc gcagcccaag 3440041 tcggagatga cccttgctgt gtctatatcg gaccaaaagg ggcagggcac tttacaaaaa 3440101 tggtgcacaa cggcattgaa tatgccgaca tgcagctgat tgcagaagct tatacgtttc 3440161 taagagaaac gcttcgtctg ccgctagatg aaattgcatc tatttttgaa acatggaatc 3440221 aaggtgagct gaaaagctat ttaatagaga ttacagctga gattttacgc aaaaaagacg 3440281 aaaaaacagg acagcctctg atcgatgtca tccttgataa aaccggccaa aaaggcaccg 3440341 gaaaatggac gagcatgcag gcgattgata acggcatccc gtccacgatc atcacagagt 3440401 ccttgttcgc ccgctacttg tcatctttaa aagaagaacg gatggcagct caagatgtat 3440461 tagcaggccc ggaagccgaa gaaaaacact tggataaaga cacttggatt gaatacgtca 3440521 gacaggctct ttacatgggg aaagtatgcg cctatgcaca aggctttgcc caatataaga 3440581 tgtcatctga gctttacggc tggaatctgc cgctcaaaga catcgccttg attttccgag 3440641 gcggctgcat catccgcgct gatttcctaa acgtgatcag cgaagcattc agtgagcagc 3440701 caaatctggc taacctgctg atcgcgcctt atttcacaga taagctccat gcctatcaaa 3440761 caggcctgcg aaaagtcgtt tgcgagggta tcagcaccgg aatctctttc ccatgcttaa 3440821 ctaccgcgct ctcttattac gacggctacc gcacagggcg ttccaatgcg aacctcttgc 3440881 aggcacagcg cgattacttt ggcgctcaca cgtacgaacg gactgatatg gacggcgtct 3440941 tccatacgaa ttggtctgaa taacctgtat taaaaacacg gtcagtttca actgaaccgt 3441001 gtttttttct tctatcccaa acaacagaag acataagtta tgttttaaat atcataaaca 3441061 gtgatacaat aatagctaga aacaatcccc aagatcatca tgtgacagca gattgctgtt 3441121 ccgttctatt ctgcttttgg ccattgtcct ttgcccttga ccatggtgtc ataaaatgtt 3441181 caaatgccaa aacggcctgg cattctgatt tacaaaagtc cctgaaaacc ttatctaatt 3441241 gagaatcagc ctctcattta ttataaaaga aatgcctaaa tcctacctgt cacaccttta 3441301 ttaagatgaa aaaaagtagg ttatggcttg acaaaaaata tatattaatt aataattcat 3441361 atataattag aattattatt gaaagcgatt atgctttcta atacattttt aggaggaata 3441421 tacattatgt ctttaatcgg taaagaagta cttccattcg aagcaaaagc attcaaaaac 3441481 ggtgaattca tcgatgtaac aaacgaagat ttgaaaggcc aatggagcgt attctgcttc 3441541 tacccagcag atttctcttt cgtatgccca actgagcttg aagatcttca agaacaatat 3441601 gctgcactta aagaattagg tgttgaagta tactctgttt ctacagatac tcacttcgta 3441661 cacaaaggct ggcatgacag ctctgaaaaa atcagcaaaa tcacttacgc aatgatcggt 3441721 gacccatctc aaacgatctc tcgcaacttc gatgttcttg acgaagaaac tggccttgct 3441781 gaccgcggaa cattcatcat cgatccagac ggcgttatcc aaactgttga aatcaatgca 3441841 ggcggtatcg gccgtgacgc aagcaacctt gtaaacaaag taaaagcagc tcaatacgtt 3441901 cgtcaaaacc caggtgaagt ttgcccggct aaatgggaag aaggcggcga aactcttaca 3441961 cctagccttg atctagtagg taaaatctaa ggagtgcatt caattggtac ttgatgcaaa 3442021 tatcaaagca caattaaatc aatatatgca gctaattgag aatgacattg ttctcaaagt 3442081 tagcgcaggc gaagatgaca cttctaagga catgctggct ctcgttgatg agctggcttc 3442141 catgtcatcg aaaatttcag ttgaaaaagc tgaattaaac agaacgccga gcttcagtgt 3442201 caatcgtgtc ggagaagaca ctggcgtgac tttcgccggt atccctctgg gccacgaatt 3442261 cacatcatta gtgttggcgt tgctccaagt gagcggcaga ccgcctaagg tagaccaaaa 3442321 agtcattgat caggtgaaga agatcagtgg tgaataccac ttcgaatctt atatcagcct 3442381 gacatgccac aactgtcctg atgttgtaca agctttaaac atgatgagcg tgctgaaccc 3442441 gaacattacg cacacgatga ttgacggtgc agcatacaaa gcagaagttg aaagcaaaaa 3442501 catcatggca gtgccgaccg tttacctgaa tggcgaatcc ttcggaagcg gccgtatgac 3442561 gcttgaagaa attcttgcga aaatgggcag cggcacagat gcatctgagt ttgctgacaa 3442621 agagccgttt gacgttcttg tggtcggagg cggacctgct ggtgcaagtg cagcgatcta 3442681 cactgcacgt aaaggcatcc gaactggtgt tgtcgctgag cgcttcggcg gacaggttct 3442741 cgacaccatg agcatcgaaa acttcatcag cgtcaaagcg acggaaggac cgaagctagc 3442801 ggcaagtctt gaagagcatg tgaaggaata tgatattgat gtcatgaacc ttcagcgtgc 3442861 gaaacgcctt gagaagaaag atctgttcga acttgaactc gaaaacggcg ctgtcctgaa 3442921 aagtaaaaca gtgatccttt caacaggtgc acgctggcgc aatgtcaacg tccccggtga 3442981 acaagagttc aaaaacaaag gtgtcgcata ctgcccgcac tgtgatgggc cattgtttga 3443041 aggcaaagac gttgcggtaa tcggcggcgg aaactctggt atcgaagcag cgattgatct 3443101 tgcaggtatt gtcaatcacg ttactgtact agaattcgcg ccggaactga aagcagacga 3443161 agtcctgcaa aaacgtctct acagcctgcc taacgttact gtcgtgaaaa acgcacaaac 3443221 aaaagaaatc acaggtgatc agagtgttaa cggcatcaca tatgtagacc gcgaaacagg 3443281 cgaagaaaaa cacgttgaac ttcaaggtgt attcgtccaa atcggtctcg tgccaaacac 3443341 agaatggtta gaaggaacgg ttgaacgcaa ccgcatgggc gaaattattg tcgacaaaca 3443401 cggcgcaaca agcgtaccag gcttatttgc tgccggcgac tgcacagaca gtgcgtacaa 3443461 ccaaattatt atttctatgg gatcaggtgc aactgccgcc ctcggcgcgt ttgattacct 3443521 aatccgtaac taatataaga aatccgctat attgccagat tggcaggata gcggattttt 3443581 ctttttctac agaaaaaaac cgaaccaggc actacggtaa aagtgctcga ttcgagcgct 3443641 tcttatagtt cctcaccatt cgtttgaatg acatttttat accactcaaa ggagtctttc 3443701 ttatatcgtt tcatggatcc gtttccttca ttgtcacgat caacatagat catgccgtag 3443761 cgttttttca tttcgccagt tgtgaaggag acaatatcaa taatgcccca cggcgtgtag 3443821 ccaattaaat caacaccatc gtacgtgacc gcttttttca atgcttcaat atgcgatttt 3443881 aaatattgaa tgcgttccgg atcatgaacc ttgccgtcct cctccagcgt atccactgcg 3443941 ccaaagccat tttcaacgat gaataacggg atttggtatc ggtcataaaa acgatttaac 3444001 gtatatctca acccggttgg atcaatcgcc catccccagt cactcgaagt gatgtacgga 3444061 ttttcgacac cattcggcaa gccgccattt acaatatcgc cagtgttatc atttttcaca 3444121 tcgcttttca cagttgttga catgtaatag ctgaagccta agtaatcgac ggttccgttt 3444181 cttaaaatct catcatcgcc gtcttcgaat gtgatgttgt agccttcgcg ttcaaattcc 3444241 ttcaacgcgt agcttggata ataaccgcga acctgcacat cagggaagaa atagcgctgc 3444301 ctcatttctt cttcagccag catcacatct tcaggattgg aggagaaagg ataaatcggc 3444361 acgtgtgata ccatggcccc aatctggaac tctggattga tgtcttttcc ttttgccact 3444421 gctaaggcgc tcgccactaa ttcatggtgc gccgtttgat acatgacttc cttggcgttt 3444481 tcgttttcgc caaccacaac acctgaattc gtccatagga acagcggatt gttcacatcc 3444541 atttggttgt taatctcgtt aaatgtcatc cagtacttca ctttatcttt gtaacgggta 3444601 aagcaagcct ctgcgaagtt gacgaagaag tccacgactt tccggtttct gaagccgcca 3444661 tattctcttg ccaggtgcag cggcatttca aagtgagaca gggtaatgac cggctcgatc 3444721 ccatgcttca gcaattcatc aaacacatca tcataaaact gcaaaccagc ttcgttcggt 3444781 tcagcctcat cgcctttcgg aaaaatccgg ctccagccga tggacgtccg cagacatttt 3444841 aatcccattt ccgcaaacaa agcgatatct tccttgtatc tgtgatagaa atcaatggct 3444901 tcatggtttg gataaaattc gttttcttca atcgtgtcag tgatttttct cggcacgccg 3444961 tgcgcacccg ctgtcatcac atcgacgaca ctcggccctt taccgccttg attccatccg 3445021 ccttcaaatt ggtgggcagc taaagcaccg ccccataaaa aatcctttgg catgtttccc 3445081 atgtttaatt cctcctcagc ttacgactgt aaatattttt tgatgtaatg cactttcctc 3445141 aatgtcttca atgaaagctt tatcaaactc aacaagcact tcgccttttt tgacggtatc 3445201 gccttctttt accttcaagg aaaaaggcgt gccgtcaaat gtcaccgtat ccagcccgat 3445261 gtgcgcaagc aattcgacgc cggacgctga acgcaggcca atcgcatgct ttgtaggcgt 3445321 aaccatgaca accgtaatga cgccgggatg gtagcatcga tttcacgata tccttcgctt 3445381 taggggtaga ccgcttcagc accaatcgaa gtctggtagc gcagcgagaa gccccaatca 3445441 cattctcttc cccgcctacg gcctctaaaa tgtcttttgc tagtctcgta taatctctca 3445501 ctttccccga catttcaccc accccttcgt tttggttacg ctttcattat aattgtaacg 3445561 gtataattta tcaattccga aacaaaatat ttacgcacta actatcattg taagcggttt 3445621 atgctataat tttgacaagt gaaactaaac gaataaatga ggaatgcgta tgttaaaata 3445681 ccagcaaatc gcaacggaaa ttgaaacata tatagaagaa caccagcttc agcagggaga 3445741 caaactgcca gtcctagaaa ccctcatggc ccagtttgaa gtcagcaaaa gcaccatcac 3445801 aaagtccctc gagctattag agcaaaaagg cgcgatcttt caggtcagag gaagcggcat 3445861 tttcgtcaga aaacataaac gaaaaggcta tatcagcctt ctgtcgaatc agggatttaa 3445921 aaaagatctc gaggatttca acgtcacctc aaaagtcatc gaactggacg tgagaaagcc 3445981 aacaccggaa gcggcggaaa acctgaacat cggaatggac gaggacatct actatgtcaa 3446041 aagggtccgc tacatcaacg gccagaccct ttgctacgaa gaatcctatt acaccaaatc 3446101 catcgtgacg tatttaaaca acgaaatcgt ctcccactcc atcttccatt acatccggga 3446161 aggactgggg ttgaagattg gtttttctga tttgtttctg cacgtgggcc agcttaatga 3446221 ggaagaagcg gaatatttgg gattagaggc tggactgccg aagctgtata tagaaagtat 3446281 ttttcacctg acaaatgggc agccgtttga ttactcgaag atttcgtata attatgagca 3446341 gtcgcagttt gtggtacagg ctaatagttt tttattatag ggctcttcac tacggtaggt 3446401 ggtcgacatg tacaaaatta tcattcctgc catactagcc atctttgcgc tctggatact 3446461 cttacagatt tcactagaga tgagcatcgt taagaatcca atgaactact ttatcgtatt 3446521 cattatcttt ttcctctttg taaagatggt gaaagaaaaa caataatagt ttgggcgatg 3446581 caaacagaaa aacatccttc ccttaacaaa ctcagccagt cacatgcatt aatcttgatg 3446641 ttaatgatat ataggtgcac ataaaaagct acttcattgt gaagtagctc cctttattaa 3446701 aggcccattt tgatccatct agttttagaa aagcgaagga caatcgcatt tatgataata 3446761 attgaaacta aatacaaaat aataaataaa acatcattac tcccaagtgt catgttatca 3446821 gattgcagca ctctttctat tcgggggtac atagtgttac ctgcctcaaa aggagcaatg 3446881 aaaccaaacg ttttattgct tatagctact aagataacag aagtcatcca ataaacgata 3446941 ctgacaccta tactaattaa tatattagga cataacacgc ttatagttcc gataattaga 3447001 atatactgca gtataactgc agaaaataaa aaaagtaata atgcaaaatg cgaaaaatca 3447061 tggtacatca acgatatgat tagcaggcct agcgttataa atgcaaaaca ttctaaaaat 3447121 aaaacagcta tctttttata aaagaaagta tagatgttct ctccaattaa cttgtaaaag 3447181 agaatatttt tgtttgaata ctctctatta ataaagaaag ctataacaaa tgaaaataac 3447241 atcaaaccaa actgggtcgc aacagtatag gagctaaaga aaaacatttc aggtgtaaca 3447301 ttactgactt tatcgattcc aacaagtaaa aaataaccca gcaaaaataa aaatacaaac 3447361 attgctccta aaataatgat aactttgttg ctaatactct ttttaaactc taatttcatc 3447421 tcaagccccc actgttttat tactcattta tatacacttc aattaattta tccactgaat 3447481 gatattgttg aatttcttgg tgattaaata tataataatc cccttctatc gcctttaaat 3447541 cagacaaatc atgtgtaatg ttgatgataa tcttctcggg gttctcctga atatacttgt 3447601 ttaagaagcc atgaatctct ataaccgttt ttttgtctaa tgaattcgtt atttcatcta 3447661 aaacaataat atttttatcc tctaataaga aactgagcaa ttttaatttt tgcttttgtc 3447721 catcactcaa atttttgatc agaacttttc catcaatatt atccagatta agtaaatatg 3447781 cgattttatc tatcattttt gcatcaaatt ttttactcaa aaagtgtaat aaaaagtcct 3447841 tagaaacatc attaggtata ttcgacgagc tggatattaa agaaacattt tgacgaatat 3447901 ctctgccgat tcttttgcta ttattcaaca aaaagtcttt agcaagctgt gatttaccga 3447961 ctccattttt tccgacaacg tgattaattt tcccgctcga aaaatgcaag tcggtgtcct 3448021 gaagtaacgt tttgcctttc acttttaaag tgtaattcgc tatattcata tacatactcc 3448081 taggaaatat ttgcataata ataaaatgtt ctgccttgtg atttgttact aatgtctaag 3448141 cttttgaggt acctctttcg tttccgatcc ggaagcgaaa gaaatgtttt tagatggcta 3448201 atttggagat cttttactct agtttacaat atataatatc caatgtacaa ctgaattcac 3448261 tgcaaggcca atccctataa tttgaatcgt aagaactaac caatgatttg tcttaaaacg 3448321 gctatattca tctaagctca gaaaagctaa aagaattttg taaccatcag aattcaatat 3448381 tgggattaag ttccacaata aagtagacga gaaaagcata aatgccatag ttaatgcttc 3448441 actggaaaat gtaaattgat ttattaattc taatgtattt attaaaagat aattgataaa 3448501 caagccaaat aaatgaacga ttatcttttc atttcttgat agcatgtagg tttcattcaa 3448561 ttggacataa aaagcaggaa atacataaaa attcagtttg aatcccactt tatcaaagtt 3448621 tttcccgaaa aattttaagg aataaatatg tcccagttca tgaagcacta tattcattat 3448681 aaaataaata actataatta tccacatttt ccagccgtaa aatactgagg acaatccatt 3448741 ttgcaatttt attaaatgaa tataatttaa tatgaacatg agagccgtaa aggataagaa 3448801 cagataaaaa aactttggtg atactttctc tttatacatt ttaaaacgta ataattgttt 3448861 atctgacaga gaatttaaac tatttttata gtattctccg ctttttttgt cttttataaa 3448921 tacgttgttt tgcacaagca cttcatattt ttcatcttca tactttaaaa ttttcattat 3448981 agtatttttc catataagga tagaagtagt ttattttttc tgcagagttg aataaggaac 3449041 cacaaactcc acaaatagag gaaaattcat aaggaatgtc aaattcctct attttgttat 3449101 tttcttttaa aatattcaaa aaccatttga atccttcttt tctaagaata aataatagca 3449161 aattggaatt taacttttcc acggttcttt cgaaactttg gttatattct tcccttaggg 3449221 ttattttcgt ttcaaaaata gcaggggaac aacatggata aatttctcca tcatgatgat 3449281 atacaatgtc atatccggga caatgtaagg aatcttcatc ttcaagactg taaaatttat 3449341 gtatgttttc ttgcttaatt ctagttttag cagcgccaac tgatatcatt ggaaattttg 3449401 ttatctttac acctaagatt gaatccccca attcctctaa aatgtggttg gacattttgt 3449461 ctttggtaac tgccatatta agagaaatat cgatatcagg gtatttcctg ctatgttcta 3449521 atatgttttt aatactggaa gacttgacaa atggagcatg gtactcatca taacttatag 3449581 tcagtgctat cacatttaaa gaattcatat catgaaagta ctcctggacc tttttcttgc 3449641 tcaaacccca aaatccatta gagatcaacg ttatttgttt ttcatatggt ttaatgattt 3449701 ccattagttc ttttaaaaat ttataatcta aaaaaacttc cccacctgta aaagaaatca 3449761 cttgaatggt tttgtttttt gcaaattcag ttactaactc tcttatgtat tctttttcca 3449821 tcctggttgt tgaagttggt gaactagaaa aacaacaatg gtcacaggat gcattacacc 3449881 ttgaatctaa attgattgat actgttttat tatacatgaa atatccccca acaaatggta 3449941 aaggagagtt agactctcct ttgtacccct ctaattaatg accacttcca agaatccagc 3450001 gattttcttt tgattttaca aaataccaaa gatcattcac ttttgctaac ttttgtgatt 3450061 catctaatag acccttaaat tctaagtttt tcacagtctc attgttagtg atttcctttt 3450121 tcatattatc cctcctcctt ttctaatata aaccaattat tctatatcat tcaatacatg 3450181 tcaatatatt gtacctaaaa aatctgaaaa atgtcactat tcttggtata taaagcctat 3450241 agtcctctag cccctctaag ctataccgaa tgaaaggcca tagtttgatt taaagcttcg 3450301 taatgaaaag taaaacatca atattgacta cactagttaa gggatataca gattttaagt 3450361 ggaagaaatg aggcaaacaa tcttacccta aaccaacctg tactgaaaag ctgttttaag 3450421 ctcttgctta ccccatttgg cacctctttc tctcgtttta attgtctcta aaagcagtta 3450481 tgcggtacta tcatataaag gtccaatgtt taaaaataat gtcatacttt taaattcacc 3450541 ttatcatgca catgctcata aagaggggtt tattctaaaa aggggatgga cggttttgga 3450601 aagcaagtac ctagatctac tcgcacaaaa atacgattgt gaagaaaaag tggtaacaga 3450661 aatcatcaat ttgaaagcga tattgaacct gccaaaaggc accgagcatt ttgtcagtga 3450721 tctgcacgga gagtatcagg cattccagca cgtgttgcgc aatggttcag gacgagtcaa 3450781 agagaagata cgcgacatct tcagcggtgt catttacgat agagaaattg atgaattagc 3450841 agcattggtc tattatccgg aagacaaact gaaattaatc aaacatgact ttgatgcgaa 3450901 agaagcgtta aacgagtggt ataaagaaac gattcatcga atgattaagc tcgtttcata 3450961 ttgctcctct aagtataccc gctccaaatt acgcaaagca ctgcctgccc aatttgctta 3451021 tattacggag gagctgttat acaaaacaga acaagctggc aacaaggagc aatattactc 3451081 cgaaatcatt gatcagatca ttgaacttgg ccaagccgat aagctgatca ccggccttgc 3451141 ttacagcgtt cagcgattgg tggtcgacca tctgcatgtg gtcggcgata tttatgaccg 3451201 cggcccgcag ccggatagaa ttatggaaga actgatcaac tatcattctg tcgatattca 3451261 gtggggaaat cacgatgtcc tttggatcgg cgcctattcc ggttccaaag tgtgcctggc 3451321 caatattatc cgcatctgtg cccgctacga caacctggat attattgagg acgtgtacgg 3451381 catcaacctg agaccgctgc tgaacctggc cgaaaaatat tatgatgata atccagcgtt 3451441 ccgtccaaaa gcagacgaaa acaggccaga ggatgagatt aagcaaatca caaaaatcca 3451501 tcaagcgatt gccatgatcc aattcaagct tgagagcccg attatcaaga gacggccgaa 3451561 ctttaatatg gaagagcggc tgttattaga gaaaatagac tatgacaaaa atgaaatcac 3451621 gctgaacgga aaaacatatc aactggaaaa cacctgcttt gcgacgatta atccggagca 3451681 gccagatcag ctattagaag aagaagcaga agtcatagac aagctgctat tctctgtcca 3451741 gcattccgaa aagctgggcc gccatatgaa ttttatgatg aaaaaaggca gcctttattt 3451801 aaaatataac ggcaacctgt tgattcacgg ctgtattcca gttgatgaaa acggcaatat 3451861 ggaaacgatg atgattgagg ataaaccgta tgcgggccgt gagctgctcg atgtatttga 3451921 acgattcttg cgggaagcct ttgcccaccc ggaagaaacc gatgacctgg cgacagatat 3451981 ggcttggtat ttatggacag gcgaatactc ctccctcttc ggaaaacgcg ccatgacgac 3452041 atttgagcgc tatttcatca aagagaagga aacgcataaa gagaagaaaa acccgtatta 3452101 ttatttacga gaagacgagg caacctgccg aaacatcctg gcagaattcg gcctcaatcc 3452161 agatcacggc catatcatca acggccatac acctgtaaaa gaaatcgaag gagaagaccc 3452221 aatcaaagca aacggaaaaa tgatcgtcat cgacggcggc ttctccaaag cctaccaatc 3452281 cacaacaggc atcgccggct acacgctgct atacaactcc tacggcatgc agctcgtcgc 3452341 ccataaacac ttcaattcca aggcagaagt cctaagcacc ggaaccgacg tcttaacggt 3452401 caaacgatta gtggacaaag agcttgagcg gaagaaagtg aaggaaacga atgtgggtga 3452461 ggaattgttg caggaagttg cgattttaga gagtttgcgg gagtatcggt atatgaagtg 3452521 aggggtgtgg ggttcaggga tggtgatatg cgctgagaaa atgattggat aaatgaaaaa 3452581 cccccgcggg atgcgggggt tcaatttaac gaaagaatcc taaaacggtt tgtagtttta 3452641 ggattctttc atcttttcag cgtgattgaa aacccttgaa gtctaggaag aacgagcatt 3452701 ggagcgcagc gaatgtttgg aattcgtgag caccgaagcg caggcctgac aacgaatgcg 3452761 agggtttgtc gacacgctga aacccccgcg ggtgcggggg ttttcttatt acagcagctt 3452821 cttccctaac agggattcta cgagctctac tgctgttttg cccgttttgt ttttgtgatc 3452881 aaggatcggg ttaacctcaa cgaattcggc tgaggtaatg atgcctgcgt catacagcat 3452941 ttccatagcc aaatggctct cccggtagct gatgccgccg acgacagggg ttccgacacc 3453001 cggtgcgtcg ttcggatcaa gtccgtccag atcaaggctc agatggacgc catcacatgc 3453061 tgataaataa tcaagggttt cttcaatgac ctttgtcatg ccaagacgat cgatttcgtg 3453121 cattgtgtac accttcatgc cgctttcctt aatgtacttg cgctcccctt catcaagtga 3453181 ccgggcgcca atgatgacga cgttttccgg tttgatttta ggcgcgtagc cttcaaggtt 3453241 aaccagtgac tcgtggccaa tgcctaggct gaccgcgagc ggcatgccgt gaatattgcc 3453301 cgatggtgaa gtttcaagtg tattcaaatc gccgtgcgcg tcataccaga tgacgccgag 3453361 attatcgtaa tgcttcgctg tgcctgcaag cgtgccgatc gcaatactgt ggtcaccgcc 3453421 caggacaagc gggaattttt tctcttcaat gactttgttg accttttgcg cgagtttttc 3453481 atttcccgcc aaaacggaat tcaggttttt cagttcctcg tcatttttga ttttttcgcg 3453541 attgatcgga atgtcaccga gatcttcaac cgtatacccc atgtctgaca gcctctcgat 3453601 cagatgagcg taccggatgg cactcgggcc catatccact ccgcgtcgtg cttgtcctaa 3453661 atccattggc attccaataa ccgaaatcgt tttatccatc tgtgattcca cctcaacatt 3453721 taagataatg tcctatgcgg gttataacaa agatgacttg cggacaacgt ttttaaagct 3453781 ctagctgacg atttgcctgc tggcgttttt taatgacgac atgataaatg atgtagcaaa 3453841 tgatcataaa cggtacgccg caatacagcg cgatacgctg ctccggatca aatgcaagac 3453901 tgatgagcac gaccgtattt aacgttaggc cgatcagcgg aagcaccggg tacagcggtg 3453961 ttttaaattt caaatcttct atcttcccgc cctcacggat atatttgcgt ctgaacatga 3454021 tttgggaaag cgagatcgta atccagccga cctgcgcgct catgcccgcc aaagataaca 3454081 gtaccatata tacggtttca gcctgcgcaa actttgtcag aagtgatagg caggccacag 3454141 ccatcgttac gattaacgag tacatcggta caccgcgctg atttgttttg ccaagcgctt 3454201 tgaaggcttg tccttcattc gccatcgcgt acagaatacg tgttgatgcg tataaacctg 3454261 agttcgcaac agataacagt gcgattaaaa taacaaagtt catgatatca gctgcatatg 3454321 ggattccgat ttgctcaaat acggcaacaa atggactttc cacgacaccc gcctgtttcc 3454381 acggaatcat gccggcaatg acaatgattg aaagcacaaa gaacacaagc gttctccata 3454441 ctgtctgttt gatggaccgc ggaatcgttt tttcagggtc ttcactttct ccggctgcaa 3454501 ccccgatcag ctcagtcccc tgaaacgcaa agttcacagt aatcatcgta atcagcattg 3454561 cctttatgcc gttcggaaat aacccgtctt cataaaaatg tgtcaaaaac ggcgcctgct 3454621 ctccgccctt cagatcaatc aggccaaaca tggcagctcc gccgagaata ataaataaaa 3454681 ggataatcaa aattttaatg cctgagaacc agaattcaga ttccgcaaag gcttttgtgg 3454741 tgatcgcatt taaaataaac atcagtgccg caaagaccag acaccagatc cacacgtcta 3454801 tatgcggaaa ccagcgttgc atcagctgcc ccgctgataa aaattcaatg gcgcatgtaa 3454861 ccgcccagcc gagccagtac agccagccga acgcaaaccc gaaggccggg ctgataaatt 3454921 tcgtggcata ggtctggaag gaccccgaca caggaaaggc gactgccagc tctcctaagc 3454981 agagcatggt caaaaacatg ataaagccgc ccactaaata ggacagaacc gcgccgagcg 3455041 gtcccgcttg gttaatggta aacccggttc caaggaagaa accggttccg atcactccgc 3455101 ccaatgaaat catgaacaaa tggcgtgatt tcattgtccg ctggagctga tttccgttat 3455161 cttggtttgt attcacattc tgcacccctt cagcaacttg tattggatct aagctggaac 3455221 atctgcatgg tgctatccca gtttgctgtc caaagagtct ctatctattt aatataaaat 3455281 tcacttcttc tcataaagat acattatact aaaatactgt agctgagcaa atagggagtg 3455341 ctgatttttc tgttgtaaat ttatacaaac gaagtgaata tcccgccatg gtgcggattt 3455401 atgcgtttcg cagcacgtgc ttaattttct ctatcgccca atccaagtcc tctttggaaa 3455461 tgattaatgg cggtgcaaaa cgaatgactg tatcatgcgt ttccttgcat aaaagtccct 3455521 cttccttcaa acgctcacaa tacggacgtg ccgcttcagt caattccaca ccgataaaca 3455581 gccctctgcc gcggacttct ttaatgacag ggctgtcaat actctcaagc tcgcttttaa 3455641 agtattcacc aagttcaaga gaacgatccg ccagcttttc atcctccagc acttctaatg 3455701 aagcgataga cactgcacat gcaagcgggt ttccaccaaa tgttgagccg tgtgagccag 3455761 ggttaaacac gcctaggatc tcgcggtccg ccgcaatgca agagatcggg aacacaccgc 3455821 cgccaagcgc tttgcccaag atatacatat ccggaacaat gccgtcccag tcacaggcaa 3455881 acgtcttgcc tgtacgtccg agacccgtct gaatttcatc cgcaataaac aagacattct 3455941 cttccttaca aatcgccgcc gcttcctgta aaaatccttc aggcggaatc acaatgcccg 3456001 cttcgccttg aatcggttca aacaagaatg ccgctgtatt cggcgtaatg gcctgtcgaa 3456061 gcgcttccac atcgccgtaa ggaatgagtt tgattcctgg aagcatcggg ccgaatcctc 3456121 gtttatattc ctcttcagaa gaaagagata ccgccagcat cgtgcggccg tggaagttcc 3456181 cgacacatgc gataatttcc gcttgattgt cagctacgcc cttcacttca tacgcccagc 3456241 gtctcgccgc tttcaccgcg gattcaaccg cttcggctcc tgtattcatc ggcagaatca 3456301 tctctttgcc tgtcagttta gctgtttttt cgtaaaacgg cccaagctga tcgttatgaa 3456361 acgcgcgtga cgtgagggtg attttatcag cctgatcctt taatgcctga atgattttcg 3456421 ggtgtctgtg cccctggttt accgcagagt aagcactcag catatccata tattcattgc 3456481 cttccgggtc ctttacccaa gcacccagcg cttcagaaat aacaatcggg agcgggtgat 3456541 aattgttggc tccgtaatga gacgtctgat caataatttc tttggattta gataaagctg 3456601 tcatatttga attccccctt gttttctgtt tcaacatgtt atcctgcttt ccctttatat 3456661 aaatgcaagt tctgtgccaa atcaagaatt cgtgtgtttt ctacaatttt cgaggacaag 3456721 gtgcaaaaac attctgatat ttcgagcgaa aatttcagca agtgcaaaat tcttttgcat 3456781 atcctctccg tttttttata aaatagaagc aatattaaga aaataattga gggaggttca 3456841 tacagtggtc aaagacagcg aattcctcac attggttttt cagagtattt tagatgaaat 3456901 cgatgttggc ctgcacgtgg tagacgagca tggaaacaca atcgtttata acaataaaat 3456961 gatgcagatt gaagatatgg agaagcatga cgtcttgaat aaaaacctga tggatgtgtt 3457021 tatgttttca aagcagcagg acagcacact ggtacaggct cttcaggaag gcaagacgat 3457081 taaaaacgtc aaacagagct atttcaataa taaaggccag gaaattacga cgatcaatca 3457141 tacatatccc atcgtccaag acggcaaaat caggggcgcc gttgaaattg ccaaggatgt 3457201 gacaaagctg gaacggctga tcagggagaa tatgaacaaa aaaggcagca caacctatac 3457261 gtttgacagt attctcggca ccagtccggc cattcaagac gtcatcgaaa acgccaagcg 3457321 ggcaacccgt acgtcatcat ctgtccttct agcaggcgaa accggcacgg gaaaagaact 3457381 gttcgcgcaa agtatccata atggaagcga tcgttctggc ggcccgttta tttcgcaaaa 3457441 ctgcgcggca ctgccagaca gccttgtgga aagcattttg tttgggacga aaaaaggcgc 3457501 gtttaccggc gctgtcgacc agcccggcct gtttgaacaa gcccacggcg gcacactgct 3457561 gttagatgaa atcaactcgc tgaatctcag ccttcaggcg aagctgctgc gcgcccttca 3457621 agaacggaaa atcaggcgca tcggttcaac aaaggataca ccgattgacg tacgtattat 3457681 tgccacgatg aatgaagacc caattgatgc aattgcaggc gaacgaatgc ggaaggactt 3457741 gtattacagg ctgagtgtcg tcacactgat catcccgccg cttcgggaac gaaaagaaga 3457801 cattttgctt ctcgcgtcgg agttcatcca gaaaaacaac catctgttcc aaatgaatgt 3457861 tgaacacatc agcgatgacg tgaagcaatt tttcctttct tatgactggc cgggaaatat 3457921 tcgcgagctt gagcatatga tcgaaggcgc aatgaatttc atgacggacg agcaaacgat 3457981 tacggcttcc catctgccct atcaataccg catgaaaatc aagccggctg acatcccaga 3458041 gccggaaaca ccaagacacc agccagccgc ggacttaaaa gaaaaaatgg aaagcttcga 3458101 aaaatatgtg atagagaacg tgttaagaaa acacggccat aacatctcga aagctgctca 3458161 ggagcttggc atcagcagac aaagcctcca atatcggctg aagaaatttt ctcactcgtc 3458221 taacgaataa tccggagcag gaagcctgat cagaaaaaca gtgcctctgc cgatttcact 3458281 tttcacttca atcgtcccat tgtgattgtc gataatcgat ttcgttatgg caaggcctaa 3458341 tcccgaacct ccatatttcc gggagcggga tgggtctgcc ttgtaaaacc ggtcaaacac 3458401 taaaaaacgt cacttcttat gcattgaaga aagaaaatgg cacctatgtg tatcacagcc 3458461 agcaaccaca cggtacaaac cattaaagtc catgcaaata acggaagtat ttgcagctaa 3458521 ctgccatttg ctgtttcacg tgtaacatcc atcttgtatt tttcttcata ttcgatatat 3458581 cctttttcaa ctgaacgggc gtgacccctg ttcagttttt tttgcatatc aaaacagcct 3458641 ggcaacgatg ccagactgct tttattaact gcctaattgg tctgcggagg acagcttgat 3458701 atcaacagat ttttcttttc cgccgcgata aaacttcacc ttcacccggt caccgacttt 3458761 tttctgataa agccgttttc gcaggtcaac aatatcattt actttgtatc cgtcaaattc 3458821 cgtgatgaca tccagttcct tcagccccgc ttttccggca ggtgaaaagg cgtctacacc 3458881 catcacaacc gctccattgg tgacgttctt aggaagcttt aatgtttcat cccaatgata 3458941 gcttgcgatg tcacttagcg atttcatctc aatgccaagg aacgggcgtt tgacctttcc 3459001 gtatctctct aaatcctcta tcacagggat cacgagctta gacggaatgg acaggccaat 3459061 cccttcaacc gctgactcgg caattttcat tgaattgatg ccaatgacct tcccatccat 3459121 atttaacaaa gcgccgccgc tgttcccagg gttaatggcc gcatctgttt gcaggacttc 3459181 agcgttccag tcaggctgtc catcaccgtt tgaatctact gggatcgccc tctccgtacc 3459241 cgagatgacg ccttgtgtga cagagcctgc aaactcaagg cctaacgggt tcccgatcgc 3459301 aataaccggc tccccagact tcactttatc tgaatttccg aaatcagcga ctgctttaat 3459361 cttatcgctt ttcacccgta aaacggcaag gtccatcagc tggtcgctgc cgacaagatc 3459421 agctgataca cgtgagccgt ctttcaagct gatttcaatt tgggaagcgc cttcgatgac 3459481 atgatggttg gtcacgacat aagcggaatg gtcatttttc ttatagatga cgccagagcc 3459541 gctcccagcc tcgccgctct ctccccaaat atctgatttt tggatgttca caacaccgac 3459601 aacggcgggc gacatattgc tgacaatctt ggtgacggca ttgttgacac tgacattcac 3459661 cgtcctgatt gattcccggc cattgttgtt ttgctgctga tctaaggcgc ctgtatccag 3459721 cccttcattt gaaaggtacg gcatgataaa cgccattaat acggcaccga caatcacgcc 3459781 aatcagactc gaaagaaaat atcctttttt gcttctcttt ggctgttcag gagtagtatg 3459841 ttcttcctca cgttcgtaat ccaccatatt ccatcctttc caagaacgtt aatatggtta 3459901 tattgtgggt tagaaactcc tagaatagtc atgatttaca tagaaaaatt atacagcgca 3459961 aagcggagtg gccttcttcg gatcggtgtc gtataagtca aatgtctcac ccgtcacaaa 3460021 tcctttagaa gccaatgtct gctgcacaga cattcttgcc agctccttca tgttgttgtc 3460081 ctggctcaaa tgcgccaggt aaatacgaga cgtctcatcg ccaatgacat ccgtcatcgc 3460141 caaggcagca tcttcatttg acacgtgccc gacgtcactt aaaatccgcc gcttaatgct 3460201 ccatgggtat cttcccattt gcagcatacc gacatcgtga ttgctttcaa acacaaatac 3460261 attcgctgaa cggataatgc ctttcatccg gtcgctgaca tatcccgtat ctgtcattaa 3460321 cgcgagcttt cggccgctat aatggaatac ataaaacatc ggttccgccg catcgtggga 3460381 aacgccaaac gattcaacat caagtccgcc gaacgacttc accgtctcca ttggaaatac 3460441 aaacttttga tcggtgtcaa ttttgccgat ttgattctcc atcgctttcc aagtcttctc 3460501 attcgcatag atcggaagct tgtactttct ggcgacgaca ccaaggccct taatatggtc 3460561 actatgctca tgcgtcacaa aaatgccgtc tacatcatcc agcttacgcc cgatctgcgc 3460621 catcagccca tccatggctt ttccgctcaa accggcgtcc actaaaaatg cgtgatcctc 3460681 tgtttcgagg taaaacgcat ttcccgtact cccgctcgca agtacgctaa attgcaagct 3460741 catgtttgtc tcactccatt attttcattg atctgtatct aaaatcgtac tctccaaagc 3460801 attcacagta aaatactctt gtactgtctt tttctcaccg ttcacttttt tctcgtactc 3460861 gaccgtaatt ctccataccg gcgccagcac ctgcgtactt gtcagcggat attgtgctac 3460921 atagccgaat ttacagctct tcacagtgct gtattctttt aattgatttt gatagtacaa 3460981 tagctcaacc gcatccattt cagtaattaa gctttctttc tggatttgct tgaaggtctc 3461041 aagcgtagtc tggtcgtatg acacaacctc gtttttaccg tttaagtgca gcaccacttg 3461101 cccgatcata ttagagggat tgtcggtctt ttggtaaata taatgacctt cgtacgtttg 3461161 gaagaaaata atttctttct tcgatttatc aaccttccaa agcttatatt tttcgccatc 3461221 ttgaattttc gaagaaacaa gtgcctgagc atcgtcctcg atatccttct ttgatagtgc 3461281 gattggattt gcaaacttca ttttcaggct cgttacttta tgatcatcac taggcatgtc 3461341 catcaaaggc ttttgatcct tcagcgcctc aatttcctcc ttggagaaag acttttgatt 3461401 tgccgtgatc cgatagcctt ctgttgcttc cttattcaag ccttcatacg tgatatgatc 3461461 ggccttcatg tcatgctcga catcattttt aatgacttca tattctttgc cggtagcctg 3461521 ccatttttga aaaaactgat agcctaagaa aatatctaaa atgaggaagg caacgatgaa 3461581 gattgatttt gtcttattcc actccactgt tagccccctc cttcctcaat aaatcctttg 3461641 taatcggcac aatttttcca tttactttca tcgcccaaac cggttccagt tcaacgagag 3461701 gatcatcgtt ggttgatgtt gataccaatt gataagcaag gaagatctga tcaattttgt 3461761 ccgtatcata agcggtttgt ttcgaaagca gcatcttcac ttcgctgccg cccatgagct 3461821 ctgtttcact tgttttaatc ggattcgttc cgagactgta attcggccgc ttatagctga 3461881 gaatatcatc attcgcccat tgcaccgtaa tcgccgatgt cgccccgaaa ggtttggcgg 3461941 tgctgttaat gaccgggatc tgatccataa aaatatagaa gctcaactgc tggctgtcat 3462001 tgatattgaa aaattgatag tgatccgtcc agcttccggt atcctcaagg tatttttggc 3462061 tctttttgat taattcacct gtttgatagg atgtgctctg caccaaattg cgctgctgaa 3462121 attgcacctg tctctggctt agattcacat ctaaccggct gatcccatct gtcagcacat 3462181 ttctgttggt gtaattcgaa tcttctctta caatgctcgg atcactaaac aaagcctgct 3462241 taaaggtatt tgttttaatc gattctgtga caaattcttt tttgtccatc gtaagcggtt 3462301 tgttcggcag caagaactct ttctttgagc caatggagaa caaactgaac gccggcatat 3462361 ttgattgcct gtttttcaag tcgttcataa tgttccggta gtttgctgat tcaaccgtca 3462421 cttcaagaat gagctgcttg ctgtatgaca ccaaatagat tttcttgttc gcttttgttt 3462481 cattgaacgg gatcagaata tggtcaaacg aactgtattc aaacgactga ttagaccatt 3462541 taaacagcgt ttggaaaata tcaatcggga tcgtatcgct gaattgcaag tcaagcttgg 3462601 cttcagaacc gcctattcca taaaaccagc ttttgaatcc agccttgtca tactgatccg 3462661 aaatatcttt aattcctttc acatcccaat gcggcaagtc agaccaaatt tcttcataga 3462721 gggcattgtc atccactttg taatgagcgc cgtcatcatg gataaacatg tcccttggcc 3462781 ttaccgtttc agacagcttt tgggtggttt tttcgatttt atgtttcaca cgaacagtag 3462841 actctgttga ggatgagcct tcagaaaagt ttggctggaa cgtccatatc ccccatgtaa 3462901 aaacaagact gatgacgacg agtaccgtaa gtaatatcgt ttttatattt tcacgcttca 3462961 tcccaatcat cctcttgttc ctctttatat ggaagagtaa atgtaatcgt cgtgcctttt 3463021 ccttctatgc tgtccgccca aatatctcca ccgtgcgcct gtaccatttc cttggcaatc 3463081 gccaatccca gaccggtgcc gccaagcttt ctcgttctcg ctttatccac cctgtagaag 3463141 cggtcaaaga ctttttcgac atcttttttc ggaatgccga tcccttcatc cttcacgctg 3463201 atatagagaa gttcttcctc ttcattgaca tcaatcgaga acgtgacatg tccgccttcc 3463261 ggtgaatatt ttaaagcgtt agaaataata ttatcgagca cctgcgttat tttatcctgg 3463321 tcaatctcga catacagatc tctgtccggc agattgcgga taaactccac atgctgctct 3463381 tttgtcattt caaaacggtc aataataagt gacataaacc ggacaatctg aatccattcc 3463441 cggttaaatt gataatcttt actgtcaaat ttcgacagct gaagcagatc attgacaagc 3463501 cggatcatac gctctgtttc attttgcgtc accattaaga agcgcggagc aatgtcttta 3463561 ttttcccacg cgccttcagc taacgcttct aaatagctgc gcattgtcgt aagcggcgtc 3463621 cgcagctcat gtgatacatt cgcaacgaat tctctgcgtt cctgatccat tttctcttgt 3463681 tcggttacat cgtaaatgac agcgattaaa ccatcaattt tgccgtgttc cctttgaatc 3463741 acagagaaat tcacgcgaag caccgttaat tcatcatcgc gctcaatttc aagcagcata 3463801 gaatcctgct gttccactaa atcttcaaaa gtataattct cttgaagccc cagcaaactc 3463861 gtaatcggca tttctaaggc tgtttcacgt gaaacgttca acagttccag cgccgggctg 3463921 tttaagagaa taatcgctcc gtttcggttt gtggcgataa cgccgtctgt catataagca 3463981 atgacagagg ctagctttct gcgttctcct tcagtcatcg cctgggcatc ttcaagctct 3464041 ctcgttaagt ggttaaacgt tgtggccagc tgcccaattt catcatgtcc atacttttta 3464101 accttcctcg agaaattccc tttcgcaagc tccatcgcct gctttcgcat atctgaaagc 3464161 gggtgggtaa tggttcttgc cagaaaaata ccgagaagag ccgtcaaaac aagtgccaaa 3464221 cctgtgccgg acgccagtat cgtgttgatc gtcttcattt gattaaagac atcttccata 3464281 ctcgcgacaa cgtagatcgc gcccacaacc tcttggtttt cagtcatgac gggcttcgcg 3464341 gaaataagaa ctctgatttt gcttttcggg tcataatatt ttcttaaata cgactgtttg 3464401 gtagaaaaga ttcttttgaa aatcagatcg gtcgtttgtt tcccagccac ttcctcaccg 3464461 tacggctttg aagaaccgac cacttcatag cttttatcta caaagctaat ttcccgaacc 3464521 tcatcacttt tcgtgaagtc attcaaaata cggctgacgt catcctttat gacggtactg 3464581 tcgttatcgc tcttatattc ttgttcgata taataagaaa ggttgtcgat tcgctgattc 3464641 agcgattgtt cataagagct gatcagcgac ttctctacct gattgacaaa atacacacca 3464701 atgatttgca tggcaatgat aatcaaaagc acataaatca aggtaatctt aaattggatc 3464761 gaccgaaaaa aaccaacctt attcatatgg gcattagtcc tgttctgggt ttctcaagta 3464821 ataacctaca ccacggcgtg tgacgatcca atttggatgg ctcgggttgt cctcgatttt 3464881 ttcacgaagc cggcggactg ttacgtcaac cgttctgaca tcgccgaagt aatcatagcc 3464941 ccaaacggtt tgaagcaaat gttcacgggt catcacttgt ccgatatgtt ttgctaaata 3465001 atgaagcaat tcgaactcac gatgagtcaa ttcgattgtt tcgtctcgtt ttgatacaac 3465061 gtacgcgtca gggaagatga cgagagagcc gatatgaatc tcgttagagg aaggctcttc 3465121 ctccgcaggc gctgttgtca gctggcggcg caggttcgct tttacacgcg ccaagagctc 3465181 gcgtgtgctg aatggttttg tgacatagtc atcagcaccg atttcaagcc cgataacctt 3465241 gtcaatttct gaatccttag ccgtcagcat aatgattggc atatcgtatt tctttctgac 3465301 ttcgcggcat acttcaacgc cgtctttatt tgggagcata atatctaaaa gaattaaatc 3465361 aggctgaagc tcttctacca tttcaacggc ttcgtttccg tcgtgggcac agtgcacttc 3465421 atagccttct tttcttaagt taaattccaa tatatctgca atcggttttt catcatctac 3465481 tacaaggatc tttttatcca tcattttgat tttcctcctg ccgaatgact tcatttcatc 3465541 tatataacat tcgtttcatc acttatggcc catgtaaaga atgggtcctt gtctattata 3465601 acggtttaag gtcaaaagat aaaaaaaata aaggtttaga aaaaaaacac atgtttcacc 3465661 tttatcgcca gttgtttatc tattgtcatg ctggtcaact ttttttaaaa aagataactt 3465721 tattgaaacc tcccctcacc ggagtgcgtc tttatcaatg acgtcttctt ctttgaaccg 3465781 gccgcagggc cggttctccc tttttcttct attataacac tcctcatgtt tgcctttttc 3465841 ctaaaagaaa aaacgcacct acgattgcag atgcgtttgg taagtggctc gggacggaat 3465901 cgaaccgccg acacacggat tttcagtccg ttgctctacc aactgagcta ccgagccaaa 3465961 tgttttattt ttctctacta agtaaagtaa aatggcggtc cggacgggac tcgaacccgc 3466021 gacctcctgc gtgacaggca ggcattctaa ccaactgaac taccggacct tacagtaatt 3466081 gcccggagag ctgtcgtgtc agctctcaca gacaaataag gaatttagca ataacgctaa 3466141 agtaaatcaa tgacccgtac gggattcgaa cccgtgttac cgccgtgaaa gggcggtgtc 3466201 ttaaccgctt gaccaacggg ccttcacgaa atggtgagcc atgaaggact cgaaccttcg 3466261 accctctgat taaaagtcag atgctctacc aactgagcta atggctctta aagatgtcgg 3466321 aatttctata gagcaaacga cttaaatcta gttctcatct tgtactctat tgaagcagtt 3466381 tccgtaacaa cgagatttat aatatcacga acaaatagaa gtggcaataa cttttttggt 3466441 tttttttcat atttttttct cagaccaact tatatgcggc tttcaaacaa aaaacaagcc 3466501 ccttaaatag gggcttgcag acatattcta tttagttcgc acggtacaca ctgcgaagga 3466561 catttgtttg tgagcggtct ggaccgacag agaaaataga aagcggaatg cctgtcagct 3466621 gagacacacg ctcaagataa tggcgcgcat tttccggaag ctcgctcaag ctcttcgcac 3466681 ctgtaatatc ctcagtccag cccggcattt cttcatatac cggctcacat tcagcaagtg 3466741 ccttaagact tgctgggaat tcttcaatga tttcgccttt gtagcggtac gccacacaga 3466801 ttttcaacgt ttcaattcct gctaggacgt caattgagtt cagagaaaga tctgtaattc 3466861 cgctcacacg gcgggcgtgg cggacaacaa cgctgtcaaa ccagccgaca cggcgcgggc 3466921 ggcctgttgt tgttccatat tcgcgtccga cttcacggat ttgatcgccg atttcatctt 3466981 tcagctcagt cggaaaagga ccgtcgccga cacgagtcgt atatgctttt gatacaccga 3467041 caacgtgctt gattttggtc gggccgacac cagaaccgat cgtgacaccg ccggcaaccg 3467101 ggttagatga cgtaacaaac gggtatgttc cttggtcgat atcgagcata accccttgtg 3467161 cgccttcaaa taatacacgg cgcccttcat caagagcatc gtttaagaca acagatgtat 3467221 cgcaaacata ctttttaatc tgctgtccgt actcataata ttcgtctaag atatcctcaa 3467281 gtttaaaccc ttctgtctcg tacattttct cgagaagacg gtttttttct tcaagattgc 3467341 gctcaagctt ttccgcaaac gcgtcacggt ctaacagatc cgcgatgcga attccgatgc 3467401 gggctgcttt atccatgtaa gcagggccga ttcctttttt cgttgtgccg atcttgttag 3467461 cccctttacg ctcttcttcc acttcatcca atttcaaatg atacggcaga atgacgtgag 3467521 ctctgttgct gattctcagg ttatctgtac tcacgttgcg ctcatgaaga tacgcaagct 3467581 ctgtgactaa tgctttcgga tctacaacca ttccgtttcc gattacacac gttttatcct 3467641 tatagaaaat tccagacggg attaagtgaa gcttatatgt gattccgtca aacttgattg 3467701 tatgccctgc gttatttccg ccttgataac gggcgatcac ttctgcattt tctgatagga 3467761 aatctgtaat tttacctttt ccttcatcgc cccattgcgt acctactaca actactgaag 3467821 acatgtccgt gcacctccgt taacctttca aaacgattct attcaaacaa atcaagttta 3467881 tcagtgaaga aacagaaagt caattgtaaa tccgaacatt aatttattgt aaatctatat 3467941 tcgttcgctt ccattcgttt tataagcgtt ttctcactgc tttgtcataa aaagcttgcg 3468001 aaactttcat cctttagcat aagaaagaat cacttgcctg atatcccttt tgaattcata 3468061 aaaacgatcc gccagccgtc cgggtcctct atcgtcacgc ccccattgct ccagtacggg 3468121 ttctctgatt cgacctcttg atagcccatg tgctttagct ttgaagtgat cgctgccagt 3468181 tcaactgcat tcggcacata aaaaacaaga aggctgtcgg gatggggaac gggggcagtg 3468241 cttccccctt catactgggt gaattccaaa tgataatcgg catgaggaag gccgaacatg 3468301 acaccgtcat acccgttatg ctgtgaaaat tctcctattc gtttcaaaca cagtccctct 3468361 tcgtaaaaac gaataatctc atcaagctgg cccgtaggac gcgcaattcg gatttgtgct 3468421 gcttgaaaag acgaaaaacg ttttcccata ttgttaccat ctcctttttg caccatttta 3468481 ttaaaacgct ttcaattttt catccgctga gcgaacgtca tttcttccat ctttcgaatg 3468541 aaaaaaaccc caagagcagc tcttggggct tatgcgccgg gcggaacgcc tgcgtcatca 3468601 aaacgccgtt ccaggttgac gaatttgttg tattctttta cgaacgcaag agacacggtt 3468661 cctaccgggc cgttacgctg tttggcgata ataatttcga taatattttt attctcggtt 3468721 tctttgtcat agtagtcatc acgataaagg aacgcgacaa tatccgcgtc ctgctcgata 3468781 cttcctgatt cccggatatc agacatcatc ggacgtttat cctgacgctg ctcaacaccc 3468841 ctggaaagct gagaaagcgc gataacaggg acttgcagct ccctcgcaat cgacttcagt 3468901 tcacgggaaa tttcagatac ttcctgctga cggttgtcct ttgaacgacc gcttccctga 3468961 atcaattgca ggtaatcgat caaaatcatg cccagcccgc tttcctgctt caagcggcgg 3469021 cacttggcac ggatttcact cactcgaata cccggtgtat catcgatgta aatcccgctg 3469081 ttcgataggc ttcccattgc catcgtcagc ttgccccaat cctcttcggt caggttacct 3469141 gtacggagat tctgggcatt gatatttccc tcggcacaga gcatacgcat aacgagctgc 3469201 tcggcaccca tctcaagact gaaaatcgct acgctctcat cggtcttcgt cgccacgttt 3469261 tgtgcgatgt tcagggcaaa ggctgttttc cctactgaag gacgggcagc cacaatgatc 3469321 aagtcgttgc gctggaaacc cgcagtcatc cggtcaagct ccgtaaaccc tgttggaatt 3469381 cccgtgatat caccttttcg attgtgaagc tgttcgatat tatcataggt ctggacaagg 3469441 acgtccttaa tattttggaa ggcactcgtg tttttgcgct gtgccacttc cataatcgtt 3469501 ttttccgctt cactgagtaa atcctcgacc tcatcctcac gggtataccc gtcttgagca 3469561 atcgttgtcg cagttctgat taatcggcga agaatcgatt tttcctcaac gattttcgcg 3469621 taatattcta tgttagccgc tgtcggcacc gagtttgcga tatctgtcaa atatgaaata 3469681 ccgcctactt cttccagcag gtctgtgttc gcaagctctg atgtaactgt caccagatca 3469741 accggttcac ctcggtcacc gagcaccagc atcgcattat agattttttg gtgggacatt 3469801 ctatagaaat catctggaat caatacttct gaagccagtg ttaaagcaga cggctgtaaa 3469861 aaaatagcgc ctaacacggc ttgttcggct tctatatttt gcggaggaag ccggtcattc 3469921 agaaggtctg tcatgctaag caccgtcctc tcattaaaaa atctccaacc tccattctac 3469981 catttctaca gaaaaaaaat agaaaaattg tctgtttcct gtttttttca gttagcagat 3470041 tggatcgttt cggacagtaa caaggcggga aaaatgcaat aaaacataag ggaggaatga 3470101 aagatgataa agaaatatgc gattacacct aatgttgatg cggacggctg gtttattgag 3470161 gtggagaatg tagcgccgac agctttgtat acgtctaaag acgccgctat tgaaaaggcc 3470221 aaacaggtgg ctaaggaaaa cagtccgtct aagcttgtaa tttatgacca gtttaaaaat 3470281 gtggaagaag aacactcatt ttaatgaatg aaagccttcg ctgcagcgag ggttttttag 3470341 cggttatcgg tttatttcat ccattggatg cctatgtgca tcatcaaatc tgccgctttt 3470401 tgatacagat cccactcccc gatcgaagca aatttcccca tcagctcctg aagctttaac 3470461 ctcattgcta tatattcttc gaaagtgaca gctttttcag tgtctatttg gtgttccttc 3470521 agcatttgtt ttaataagga taacggtgcg tgcataagaa ccctccttac ctcttttata 3470581 acggtcattt tccgattgct ctattccttt gtgacatctt cttacatttc acatctgatt 3470641 cttgtacaat ggacagaaga gaggagggat cttttgtgag acctttgcaa atttctgccg 3470701 aaactgcaca aaagcttgca gagtccttga atctgccgct tgaacagatc atgcatatgc 3470761 ctcagcatat tctgcttgcc aaaatggctg aactgcaaaa agaggacaaa tcatagcctt 3470821 cattcacata cttgcttacc tgtttcggga taatatcatg tatatgttag aaaagaggag 3470881 taactgcttt gccacatcca cataataaaa aaatccaatc attttggctg atcaccggca 3470941 ttatctttat cgcctttaac ttacggcccg cgatcacttc agtcggtccg gtcatcagct 3471001 ctatccgggc agagctgcac atgtccaatg gggcagccgg ttttttgacc gcactgccgc 3471061 tgctttcgtt tgcagttctt tctccgcttg cacctaagct tggacagcgc ctcggtaatg 3471121 agcgaacttt atggctaggt ctcgtgatac tgctgatcgg tgttctgact cgttctaccg 3471181 gctatactgc cgctttgttt ttcggaacag cacttatcgg cgtcgggatt gcgattggta 3471241 acgtactttt gccaagctta atcaaacata aataccctga aaagccaggg atcatgatca 3471301 gcctgtatac gacatcaatg aatatattcg cagctttagc atcgggtgtc agcgttcctt 3471361 tagcgaccca gatgaatggc ggatggaaac aagcctttct cttatggggc gggctggctt 3471421 tacttgcatt gctaatctgg atacctcagc tgcgccatcg agatacggca aaccagacaa 3471481 tgaagctgca atccagttcc atttgggctt ccaaaatggc atggtatgtc accatcttta 3471541 tgggcctgca atcgttttta ttttacagca gcatcgcttg gtttcctgaa attctccgtt 3471601 cacacgggat tgatacggca acagccggat ggatggtatc actcatgcaa tttgcgagtc 3471661 tgccttccac ttttctgacg ccagttttag ctgaccgtgt gaaacagcag cgcggtatcg 3471721 ttgcggcgct ggcctcagtt tatctgatcg gcctttgcgg attattagcg ggcggaagcc 3471781 atacattgct tgccatctgg atgatcatta tcggtatcgg acaaggctcc agcattagtc 3471841 tggcccttac tttgattggt ctccgcagtg aaaatgccca acaggccgct gcgctgtcag 3471901 gcatgtctca gtcattcggc tacctgctgg cagcagtcgg gccaatcttt gtcggctatc 3471961 tctttgacca gacgcattct tggacgatgc cgattgtgct tctcattgct gccctgatcg 3472021 taatgggagc agccggacag ggagccggac gagatcgata cattttccag tcagaaaaac 3472081 aaagaaattc agcataaagc ggggaagata tctccgcttt tttctttgaa tatttatggt 3472141 ttattcataa gtttttcata tttgtttttt acaatgagac accataaaga ggtgaaaaac 3472201 gatgaaaacc aaacgattcg acgcagccct tattcttatt ttgctagcag cagctttttt 3472261 gaatacgtat cacatttggc aggatgatac agcaaaccag tactatttgg cggctgtaaa 3472321 aagcatgacg caaagcttcc ataacttttt ttatgcgtca tttgaccctt ctggatttgt 3472381 gacagtagat aagcctcctg tcgtgttatg gattcaaacg attttcgcac tgattttcgg 3472441 tgttcacacg tggagtgtca tcattcccca ggctcttgcc ggagttggat ctgtcttcct 3472501 tctctacaga atggttaagc cgacttttgg agttggagcg gcccgcattg ccgcacttgt 3472561 catggcactg acccctatcg cagtagctgt cagccggaca aacaatatcg acagcatgct 3472621 tgtttttacc ttattgctcg gttcaacttg tctgcttagg gcagtaaaac aaggcaagct 3472681 ggtttggctg ctgacggcat ttgccctgat tgggctcgcc tttaatatga agatgatgca 3472741 agcgtttatg gtattgcctg catttgtgtt attctacctg attgcatctc gggtttctct 3472801 gaagaaaaaa atcgggtccc tgcttctgtc tcttgtcctt ctgacaggcc tttcactctc 3472861 atgggcgatt gcagtggatt cagcctcttc ctcaagccgg ccttatgtag gaagcagcca 3472921 gactaactca gtgctagaac tggcctttgg ctacaacggc acagagcgtc tgtttgggca 3472981 aactacgggc cttgcaaagg gtgatatgaa tgctgctggc ggagggaaca tgcagaatca 3473041 agacaacatg caagcgccaa atggcaacgg ttcatctttt tctcagaacg gtaatcaatc 3473101 attcggaaac cattcacagg cgcctcagcc gcctaacgga caaaccggcg ctctcaatgg 3473161 aggcggaggc acacctccca caggtggcaa cggacctgga aatggagggc ctggcggcgg 3473221 aggcggaaaa agcgtgaata tgttcggcac cggtgatcct ggaccgcttc gtctcttcca 3473281 atcagcactt tccggccaaa tcagctggat gcttccattc tcattgatcg gattactggg 3473341 cgcaatcatc agctggtacc gtgatcgccg cggacatgct gctaaaatga aagaaacgct 3473401 attctgggcg gcttggcttg ttcccgtggc tggtttcttc agcatcgcag gattcttcca 3473461 ccagtattat ttgattatgc tggcaccgcc gattgccgcc ctttctggta tcggatggta 3473521 tacgatgcac cgcttataca aaaataataa agactggtcc agctatcttc tgccggcagc 3473581 cgtcttgatc acagccgtgt ttcaggtgta tattctgagc gcttatacaa gccaaatcgg 3473641 cagtgtatgg atgtatgtcc tggggctctt aggactgggc atcacccttg cacttctgat 3473701 gcttaaacgc agccatccgt tcagtaagct gctgaccatc atcagcttgt gcgttctgct 3473761 tctcacacca gtttactggt cagcaacgcc gcttctatac ggtggcaaca gcgtccttcc 3473821 tgaatccggc ccgcagctca aaggctcagc aaacggcggg aacatgttct cttcagaggt 3473881 cgacagcggg ctcctgtcct atctgagaaa acacaatacc ggcgaagagt atttatttgc 3473941 tactttgaca accgtaacag ctgcgccata catcatttac gaaaatgaat ctgttatggc 3474001 aatgggcggg tttaacggca cggatcccat tctgactgtg tcggaactga aaaaactgat 3474061 caaagaaggc aaagtgaaat acttccttct gtcagaaaac aactcaggca acagcgaact 3474121 tgtttcctgg attaagaaaa acggaaaaga aataacatct gacgagtaca gcggttcctc 3474181 cagcagcaca aacagcgtgc agggaatgcg aagaggacct ggcggagaaa gccagcaaac 3474241 tctttatctc gtggaataaa aaaagaggct tggatgaatc caagcctctt ttctattaag 3474301 cttcttcttt tacatgtacc tttaacacag cctgcacttc aggatgcagc ttcacaggca 3474361 cgtttgtata tcctaatgca cgaatgccgt ccggcagttc aagcttccgc ttatctactt 3474421 taatgttatg gtctttttgg agctgttcag tgatttgctt gcttgtcact gaaccaaata 3474481 aacggccgcc ctcacctgat tttgcgctaa gctcaacagt cagtttttct aatgtctctt 3474541 tcaagctctt agcctgctca agctcagcaa tggcttcttt tttctctttc tgcttttgtc 3474601 cgtttaacgc gctgatgttt gacgcgttcg cttcaaccgc gaggcctttt ttaattagaa 3474661 agttatgcgc ataaccgtct gctacgtttt tgacttcgcc tttttttcct tttcctttta 3474721 catcttgtaa gaaaataacc ttcatctctg tacgcctccc tcaaaatact catctatggc 3474781 gtgcttcagc cgttccagcg cttcagaaac tgaaatgccg gacaactgag tcgccgcatt 3474841 tgttaaatgc cctccgcctt ccagggcctc catgatgatc tgaacattta cctcgccaag 3474901 cgaccgagca ctgatacaaa ccgtttgttc atcccgtctc gccaccgcaa atgaagcctc 3474961 aacctcactc atcgatagca gcgaatcggc agcctgcgca atcagcactt gatcgaagta 3475021 ttcctcttca ttttcaggaa gagaagcaat cgcaatgtta tctttataga ggaccgtatg 3475081 ctggatcagc ttcgcccgtt taatatagga atcaacggtt tctttcagaa acttctgcac 3475141 cagcaccgtg tcggcgcctt ttgcccttaa ataagaagcc gcatcgaaag tccgcgagcc 3475201 cgtgcggaga gaaaagctct ttgtatccac tattatacca gctaataggg ctgttgcttc 3475261 aatcatattg atttttaagc gcttcggctg atattcaagc agctctgtca ccaattccgc 3475321 tgtggaagaa gcgtatggtt ccatataaac gagcagcgga tctctgataa actcctcacc 3475381 tcttcggtga tggtcgatga ccacgatatg ttcaatttta ttgaccagcc gttcctccat 3475441 gacgagtgac ggcttatgtg tatcaacgat cacaagcagt gtgtcatcat tggaaatctc 3475501 cattgcttct tcaggcgtaa taaatcttga ccacagttct tcatattttt tgatttcccc 3475561 aatcaaacgc tgcacacttg atccgatttg gtttgggtca atcacgataa aaccatcttt 3475621 gttatttgcc tgagccacct ttaaaatccc gatcgctgcg ccgatagaat ccatgtcggg 3475681 gaatttatgc cccatgataa tcacattgct gctttcggtg acgatttcct ttaaggcgtg 3475741 agaaatcacg cgggcccgca cccttgttcg tttctccatt gggtttgttt taccgccgta 3475801 aaacttcacc ttgccgtttg gcagcttaat ggctacctgg tctccgccgc gtcccagtgc 3475861 taagtccaag ctggattgcg ccaaatcgcc aagttctttc agggaagaga ctgaagcccc 3475921 gacaccgacg cttaacgtca gcgctacacc gtcaaacgag gttttttccc gcacttcatc 3475981 aagaatcgaa aacttcgaat tttcgagttc agttaagata tgttcattaa gtacagcaat 3476041 aaagcgttct gaagacgtcc ttttcaagaa gatcccgtac tcctgcgccc aagcgttcag 3476101 caaagatgtc acctggctgt tcatcgtgct tctcgtctgg tcatccaatc cttgtgtcac 3476161 atcatcatag ttatcaagga aaatatatgc caggacggtt ctttcgtttt catatagctt 3476221 ttcaatctgg atttgttctg ttacatcaaa gaaatataag agacgctcat cccgtttgat 3476281 gacaacccta aacttgcggt cattcaatgt aaccgtttcc gattccacct cttgtttgat 3476341 aagcggcact accgattcac aagtatcgta aagtgatctc cccactaaag tgctttcatt 3476401 aaaacaagag gaaagaaacg gatttgccca ttctatataa tattggtcat taaaaagcat 3476461 gattccaatc ggcatttcca tcaatgcctc ttcaccgact tttttcaacc tgtaggacaa 3476521 cgtagaaata taagcatcaa tctcttgtcg aataagagaa tcagcacgct taataaaaaa 3476581 caaaataact gccagcagca gcacttcgac ggttcctaat atccagttaa aataaaagct 3476641 gatgaggatt gtaataattg acagagcaat caatgcatag atgggatacc gaaacagcgg 3476701 tttttcataa aagcttggca tttctatcac tccccaccat gtgagtaaaa ctcatgttca 3476761 cttcacctta ttccttatat gaaagcccat atctaaaacg cctaaaatgc gaatggccgc 3476821 catgaagacc ggatgcacaa acccaagtat gacagcaatc acagccgcag cctttggata 3476881 ttgtttctta tggcaataga aaaagataaa tgataaacct tggatgaaaa tcagaaaccc 3476941 gagtataaac tccccattta aagcgataga gtacagcatt tggccttttt ctaaaggcaa 3477001 aaatgaaagc atgacaataa tcaaatacag tactacaaca ctttgcggaa acttcaactc 3477061 tctaaaaggc tttagattag gaatatcggg ggagaatcgc cttaagagcg gcttagcgat 3477121 aaggtaactg aggaaagaaa aaataactcc taccatcaca atagctgttg gaaaaagata 3477181 ttgaacgata cccaattgtt cttccatcag ttttaattgc ttctcaaact gcccagcatt 3477241 gcccgactgc ttcgctacag tttctacaat atcaagagat tgccggtatt gtgtcattgc 3477301 ctcatcaatg atattgatac ccaaaaactg aatgcttatc acaaaataga agacaatact 3477361 aagcatataa ataagagcgc ccgaaataat ggcgtgcccg ggctctttcc ttttgaaaaa 3477421 atgtcccatg gcaatgccgg cgcaagctga cataaaagct acaataagcc cgttaaagga 3477481 cccgacaata aaaacaaccg gaagactgac agcgcccatc catatcccta gcttcaatcc 3477541 atgtctgatc gtatacaaga tcattggcag cggcagtgca aataacagaa ttgttccaat 3477601 cacaggaaca taaacgacca gaagcgtaat gatcgcaaac agactgatta aaatagcacc 3477661 ttccattaaa gctctcgttt gtttcactta gtcacctcgt atcatcctga acatacgaat 3477721 agaaaagagc agcataaacg actgctcttt tgttcatcgc tgcaacatgc tttgcaccga 3477781 atgtttttat atcatctcta aattttactt ttatatttta acataagtcc aaatcgcaag 3477841 taaaatgacg ctaatgtttc atgtgaaaca tgaaaaagga aaagacattc tttgaaaaga 3477901 atgcccatca caattaatgt ttatcatcca taaagccaga agattccttg tttttctttt 3477961 tcgtttttct gacatacata aaaattaaga tcaccagtaa aagggttgtt gcttgcagaa 3478021 cgccgctgct aaacaagaaa aagttcttta tcatgtccca cattgtgttt cacctctttg 3478081 tgcatgttct caacccgtat cctatataag gtgaatttcc ctttttaaaa acttcaaaac 3478141 atcatgaaca acattgagcg ttgggcatat gctgatatgg aatctgatcg ataaaggaga 3478201 attttcacat ggatgaacgc agaacattgg cttggcatga aacattagaa atgcacgagc 3478261 tggttgcttt tcaatcaaac ggactcatta aactgaagaa aatgataaga gaagtaaaag 3478321 accctcagct cagacagctt tataacgtgt ctattcaggg tgttgagcaa aatttgagag 3478381 agcttcttcc gttctttcca caggctccgc acagagagga tgaggaagaa gaacgcgcag 3478441 ataacccatt ttacagcggt gacctgctcg gttttgccaa aacatctgtc cgcagctatg 3478501 ccatcgcaat tacagaaaca gcaacacctc aattaagaaa cgtactggtc aaacagctga 3478561 atgctgccat ccagctgcac gcccaagttt atcgatacat gtatcagcat ggatattatc 3478621 cgtcttacaa cctttctgaa ctgttgaaaa acgatgtcag aaacgccaac agagccattt 3478681 caatgaaata aaacaagcag caaaggagtt ccctttgctg ctatttctgc tgatccttca 3478741 ctaagccgtt cgaacgataa gattccagca cgtctctgtt ggattctccc cattctttca 3478801 tttgcaaaac aatcggttca agcgtgcgcc caaattccgt cagagagtac tctaccttgg 3478861 gcggcacctg gtgataaacc tcacggtgca cgatgccgtc cgcttccagc tccctcagct 3478921 ggagagtaag cattctttga gtaatactcg ggcagattcg ccgaaactca ttaaatcgtt 3478981 tcttgccatc tatcatgtga taaaaaagaa ttcctttcca ctttccgcca atgacatcta 3479041 gagtgaattc aactggacag ccttctttgt tcgggtatat attctttttt tcactcattc 3479101 ttgaccctcc aatagtacct tttttgatac tacattacat tttgcaacta atctacccag 3479161 tattttacac accttttctc cttagctcaa agaaaatgct tcttattcac atcaattttt 3479221 aagggtttgc atgattacac ctgcagcaag acgtgttaaa ctatataaag attacactac 3479281 ttaaaaaagg ataggagcta tcatggaaaa gatacttatt ttcggacacc aaaacccaga 3479341 tacagatacg atttgttctg cgattgctta tgctgatttg aaaaacaaac tcggcttcaa 3479401 tgctgagcct gtccgcctcg gacaagtcaa cggcgaaaca caatacgcgc ttgactattt 3479461 caaacaagaa agcccgcgtc ttgttgaaac agctgcaaac gaagtaaacg gcgttatcct 3479521 ggttgaccat aacgaacgcc agcaaagcat caaagacatt gaagaggttc aggttttaga 3479581 ggttatcgac catcaccgca tcgctaactt tgaaacagct gagccgcttt actatcgtgc 3479641 tgagcctgta ggctgtacgg ctaccatctt aaacaaaatg tacaaagaga ataacgtgaa 3479701 aatcgagaaa gaaattgccg gccttatgct gtctgcgatc atttctgatt ccctgttatt 3479761 taaatctcca acttgcacgg accaagacgt agcagcagca aaagagcttg cggagatcgc 3479821 tggagtagat gctgaagaat acggcttgaa catgttgaaa gcaggcgctg atctaagcaa 3479881 aaaaacagtg gaagagctca tttctcttga tgcgaaagaa tttacactcg gcagcaagaa 3479941 agtcgaaatc gcacaagtaa acacagtgga cattgaagat gtaaaaaaac gccaagctga 3480001 attagaagct gtgatctcaa aagttgtggc tgagaagaat cttgatctgt tccttctcgt 3480061 tatcacagat atcttagaaa atgattcact tgctcttgca atcggtaacg aagcagcgaa 3480121 agtggaaaaa gcgttcaacg ttacattaga aaacaacaca gccctcttaa aaggcgttgt 3480181 ttcccgtaaa aaacaagtcg ttcctgtctt aacagacgca atggctgaat aagccattac 3480241 aattgcttca aaatccttgc ggggtttccg cctacaacag tattagcggg tacatcctta 3480301 gtgacaacag atccagaagc aatcactgcg ttatcaccga ttgtcactcc cgggttaatc 3480361 accgcccggc ctccaatcca aacttgatct ccaattgtca caggcttacc gaactccttc 3480421 ccggatttcc tttcgatcgg atcaagagga tgaccggccg tgtagatatg tacacctggc 3480481 gcaatcaaac aatgacagcc gatacgcacc tcacacacat ctaaaatgac acagtcaaaa 3480541 ttaacaaatg tatgatctcc gatatgaatg tgatagccat aatcacagcg gaatgtcggc 3480601 aaaatcgtga cttgatcccc aaccgaaccg agcagctcct tcaaaagctt cgtccgcact 3480661 gcatcatctt ccggtgtttc gttgtattgt ctaatcagct gtctcgcatg cttgcgttct 3480721 agtaatagtt gttgatcttc cgaattgtat aattctccgg ctgccatttt ttctttttct 3480781 gtcctcagca tttaagtcac tccagatgtc agattgtaat ctcgatcaaa tttccttcat 3480841 catcctcaat cacgctttca tagtagccgt ctcctgttgt cctcgggccg tttactactg 3480901 cgaaaccatc cgccttcaat cgatcagtca gttcgtcaac tttctcccgg ctcccaacgg 3480961 aaaaggcaat atgtgcccag cctgtcattg tttgtgaggg cggatcggtc acattccctt 3481021 ttttcataat ttccagcctt gctccggaat caaacgtaat aaaataagac ttaaaatctt 3481081 ttttctcatt atgatacaaa tcattcgctt cgccattaaa atacgattca taaaaagact 3481141 tcattcgctc taaatcattg acccagaccg ctgtatgttc aatctgcatt tcttcctcct 3481201 ccttcgcctt caatgaagtt ataaggtatg aaatgcattt cagttcaagc ttttttctta 3481261 aatttatgct gaattttgat atcagcgggt tcatcctgca aaaatagaga aaatgctgcg 3481321 atgccgagct gctcaagatt caaatcaagc gacggaaaac caagaacacg gctgatagaa 3481381 gtatttccct cgcctatgat ttcaacatcc caattattct ttttggcaaa tagatgaatt 3481441 ccagctgcca cttcatcact atttgcataa atagcagtcg gaacccgccc gctcatataa 3481501 aaatgttcag ctgccagctc accatcattc atatcgttgc atccggacag catatggcgg 3481561 tcttccaacc ttccgcagac agctttatag gccgcagctt tatcagccgt gctcgggctc 3481621 ctatcagctt ctctgacaca cgtaaaagca atattctcat gcccgcggct ctttaaatag 3481681 cgaaagctct ctgcataagc agtttttctg tcattaaaag cacaagggac atcaatgtct 3481741 ccggtatcct cacaagcgat gaccggccca tattcctgat aagctaaaat gctgtcccaa 3481801 tgattggcgc gggaagtaat gatgagaccg tctattttct tcgttcttaa cagctctaaa 3481861 tatttgattt caatatcggg gttataattg gtggggagaa gggtcgttgc atactcatgc 3481921 tgaaaagccg ccttggtgat tccgttaacg attttatcaa agcagggatg atcgctataa 3481981 ggcagaatca caccgaccgt atgggttttc ccgcgaatga gatcgattgc ggttcgattt 3482041 ggtgtataat ccaattcctt catgacttga tgaacaagct ttctcttttc ttcagataca 3482101 tacggatgat gattcaatac acgcgagaca gtcgaaacag atacatttgc cagtcttgcg 3482161 atctctttta tatttgccat ctctttctcc ttttcatata aaaaaagcag taagtgtaaa 3482221 atccttactg ctatctcatc atatattgat gataagttca acaggacaat ggtcggaacc 3482281 catgacgtcc gctgatatgc tggcatcttc aatctgttcc ttaaggcttt cagaaacaac 3482341 aaaataatca atccgccatc caatatttct gtcccgggcg ccggcacgat acgaccacca 3482401 ggaataagcg ccttcaagat caggataaac atgacgaaaa gaatcaacaa agccagcttc 3482461 taagaaacga gtgaatgcct ctctttcttg atctgaaaat ccagcgttat tccggttcgc 3482521 ctttggattt ttcaagtcaa tctcctgatg ggctacattc aaatcaccgc ataaaatcac 3482581 tggttttttc tgatccaatt caagaatata agacagtaaa gcctcttccc attgcatgcg 3482641 gtaatcaatc cgctctaatc cccttctgga attgggcgtg taaacagtca tcacaaacac 3482701 gttttcaaat tccagcgtaa tcactctgcc ttcttggtca tgctcttcta ctccgatacc 3482761 gtagatgacc tgcagcggtt cttgcttaga aaaaacagct gtgccggaat atcctttttt 3482821 cactgcataa ttccagtaca catgatagtc ttcaggctgg agatcaacct ggccgtcctg 3482881 tatcttcgtt tcctgaagac atataatatc tgcatcctct tctttcaaat aagagaggaa 3482941 atccattttt ctcatcacag cccgcaggcc gtttacattc catgaaatca acttcatgtt 3483001 tcatcctccc ccctataaaa aagagcaaga acccgaaggt ccttgctctt tacatatcag 3483061 cttactcacc gcttacgtat ggaagtaaag ccatttgacg tgcgcgtttg atcgctgcag 3483121 tcaatttacg ttggtattta gcgtttgttc cagttacacg acgtggtaaa attttaccgc 3483181 gctcagaaac aaacttttta agaagatcta catctttgta gtcgatgtgc gtgataccgt 3483241 tagaagtgaa ataacacact ttacggcgtt tcgcacgacc gcctctgcgt cctcctgcca 3483301 ttgtcatttc cctcctttct ttttcatttt aggcgataat cacattagaa tggaagatca 3483361 tcatccgaga tgtcaatcgg tttgccgtcg ttggcaaatg ggtcatcatt aaagctgttc 3483421 ccctgattgc gtctctggtt gttttgattt cccccaaatg gattatcatt ttggcctccg 3483481 ccaaagtact ggcctccgcc gctgtttcct tcgttgtatc cacctgaacc agaaccgccg 3483541 ccgtttttcg gctcaagaaa ttgaacactt tcagcttgga cctctgtcac gaagacacgc 3483601 tgtccttgct ggttttcata gtttcttgtt tgtaaacggc catctacgcc tgcaaggctt 3483661 ccttttttca agaagtttgc aacgttttcg gcttgtcttc tccaagtgac acaattaatg 3483721 aaatcggcct cacgttctcc ggactggttc gtaaatgtac gattcacagc aagagtaaac 3483781 gtagcaacag ccgcaccgtt tggcgtataa cgaagctctg ggtcttttgt cagtcttccg 3483841 actaatacaa ctcggttaag cataagaaag accacctttt accattatat atttcaaaat 3483901 tgcttattct tcttctttaa caacaatgtg gcgaatgata tcgtcactga tcttagctag 3483961 acggtcaaat tcttgaactg ccgcagcgtc agattgaacg tttacgattt ggtagaaacc 3484021 gtcgcggaaa tcgttgattt cgtaagcaag acgacgttta ccccaatcct ttgttccagt 3484081 gatctccgca ccgttagaag tcagaacgtt gttgaaacgc tcgataactg cttttttaga 3484141 ctcttcgtca atgtttgggc ggataatgta cataacttcg tactttctca tctgtttgca 3484201 cctccttttg gactaagcgg cccataatgg gcaaggagca ataattctat tactcacaat 3484261 tttatattat accaaagctc ttgtcccttt acaactgcat cctatacatt aaatcggaaa 3484321 tgaataacat ctccgtcttg gaccacatat tctttccctt caaggcggac ttttcctgcc 3484381 tctttagctc ctgccatacc gccgcccgca agaagatcct cataagcaac tgtctcagca 3484441 cgaatgaagc cccgctcaaa gtcactatga ataattcctg cacactcagg ggctttcatg 3484501 ccttttttga atgtccaagc tctgacttcc tgttctccgg ctgtgaaata tgttgcgagg 3484561 ccgagaagag agtaagacgc tttgatcagc tgatcaagac ctgattcttg aatgcccagc 3484621 tcttccaaga acatttgctt ttcttcgcct tcaagctcag cgatttcaga ttcgattttt 3484681 gcacacacaa cgataacttc tgcgttttcg ccggcagcgt actcgcgaat cttcgctaca 3484741 ttttcattgc cagatggatc agcaacttca tcttcactta cgttggccac gtacaaaata 3484801 ggcttcgaag tcagtaaatg gagctgcttc acaagctttt gctgctcttc agtgaattct 3484861 acagatcgag caggcttttc actctcaaac gcttctttca gtttagataa aatctcaaac 3484921 tcaaatacag cgtctttatc tttttgcttc gcaagcttgc tgacgcgtgt aatccgcttt 3484981 tcaactgttt ccatatcagc gaggatcagc tcaaggttga tcgtttcaat gtcatcaatc 3485041 ggatcaacct ttccggaaac gtgtgtaatg ttgtcatcgg aaaaagcacg gacaacgtgg 3485101 caaatcgcgt caacttggcg aatatgagat aggaacttgt tgccgagtcc ttctccttta 3485161 gatgcgccct ttacaatccc tgcaatatca gtgaattcaa aagcagtcgg cacagtcttc 3485221 ttcgggttga ccagctcagt cagcttttgc agacgatcat ccggcacctc tacaattccc 3485281 acgttcggat caattgtaca gaacgggtag ttggctgatt cggcaccggc ctgtgtaatt 3485341 gcgttaaata gtgttgattt tccgacgttc ggcaaaccaa caattccagc tgttaaagcc 3485401 attctttcat ctcctctata taaaaccgtc attgtatgaa cgtattttga acctagagca 3485461 attataagga ggttcactgg aaaagacaag ctgacaaaaa agcattttca gcttgccaat 3485521 ccctttgatt atgctttttt caagcctact aaacagtcaa aaagcgtact tcccattcca 3485581 ttatcagaat ttgtatcatt tgtcagtgca ttgactgacc ctccaaaagc cgcccacatg 3485641 ccttcatcta tattaatcgt cttcgcatga gcctgcttca tcactttcac cttgcccttc 3485701 atgcttccgc ggtcattaaa gatgacaact tcgtctccat cctgaagatc ctgcccagcc 3485761 gctatatctg gagaaatatc gacctgaacg tgctgaagct tttcaataaa cggcacatgc 3485821 tgtgaatgat tggaacgctg cggatgaatg gataagagcg tataagggta ctttccagct 3485881 aactcctcat tatggaaaac agattcttcg ggcacattta attgaagcga gccgctaaat 3485941 cctttttgct cagctagcga cgaagtaaat tcaaattttc cactcggcgt caaaaactga 3486001 taatcatccc acggcacctg ttttactgga agagggaggt ggcctttttc ttttaaacgc 3486061 tcaagtgtca catcctctgc ttccaatgaa gaaagcccca tctctaaaaa ttcttgagtg 3486121 ctgtattcaa acagctcgcc aaacccaaga cgttttgcaa gctctgacca gatccagctg 3486181 tccgatttcg cttcaccctg cggctccaca agcttcttcc cgtactgaac ataatgatga 3486241 tacatactgg aatagtagat atcttcttct tcaaaaacag tggcagtcgg caaaacataa 3486301 tcacacagct ctgcggtatc cgtcataatg gaatcaatcg cgaccgtcat tggaaccttt 3486361 tcaaatgctt gtctcacctt atttgtattc ggcacctgag tcagcggatt tccgcacgtc 3486421 acaataatca tctcaatcgc aggatcagca gcggtcaaca cttcttcagc ctgtgtcatc 3486481 attgaaaaag aacgggatgt tgtttttaat tccggcagcg tcagctttgt ttttgcaaag 3486541 ctctcaccaa tctggacatt tccgaaattc gcgccgccgc ccttaattcc gacatttccg 3486601 cttgccgcca caagtgcatc aatccaacga atcgttcccc cgccgttttt atatcgctgc 3486661 atgccaagcc ccataaaagt agacaccgga ccatcagcat acaaacctgc caaatactcc 3486721 agctcctcca tagaagtttc tgttttcaca ataaactctt ccagagaaac ggtcttcaaa 3486781 agctctttca catcatcaaa accgacagaa tgctcagaaa taaacgtttc atccgttctt 3486841 cccatctcaa tcagaacctt caaaacggct gccgcaagcc agccgtccat tccaggcttt 3486901 acagagatat agcggtcggc aagcttagca gtcgggttga agatcggatc aatcaccgta 3486961 atcgtggcgc ccttcttttt cacctgctgc aagtgatggt ataagtgcat atttgttctt 3487021 gatacatttc ttccccacac aacaacatgc ttgctgttgt aaatatcaag cggtccgtga 3487081 ccgtacgaac ggccaaaatc ccagctttgc gcctcgatac cggagcccca gcatatgctt 3487141 ccgacgattt cggtcacgcc gccatatcca ttaaaaaaac gctgatcaag cgcttttaac 3487201 agaccgttat tcgcataatc atggctgtgc aaaacagcag tcgtctccga cgtttccttg 3487261 atttcccgaa gtttatcggc aatttcatca agtgcctgct cccaagaaat ccgcacaaac 3487321 tcgccatttt gttttttcat tggatagcga agccgatcag gcgaatttgt ttttgtctca 3487381 agcattctgc cgcggccgca gattttacct tccgtaatcg gatggtttgg atctccgtcc 3487441 acttttgtta cctttccatc atcaacagtc accaaaaagc cgcagctgtc ccaacaattc 3487501 agcggacatg ccgactgatg cactttgctc atcgccgtct tctccttacc ttctatatga 3487561 aaaagcatga gtgtcggcct atttatgaag taggctcctc atgcttgact agtacttttt 3487621 ttagttttct ttcaaattct cttctcggaa tcataacact gtgagagcat ccctcacact 3487681 taattcgaat atccattccc atgcgtataa ttttccagct gttcgctccg catggatgcg 3487741 gttttttcat ttctacgata tcattcaggc caaagtcttt atccgccaag acccttcacc 3487801 tcttttccta aactgctgta tctattgtac aaaaaaactg atcataagag caatcaagat 3487861 acccgaaaag aaatacatcc tcttatttcc atttactcaa aataggatat aagagcagac 3487921 aaactaacaa atacaaattg agcatcccat atatcggata caagaacgcg atcaaatcag 3487981 aaaatccgaa agaagtaaaa ggtaccatta acactaacaa aatcaacaca atcatccatc 3488041 tcggcatatg aataaacgcc atcagccggc tggacaaacc cagcaaacca gctaccgtcg 3488101 tcgtgtaaat cgccaggcac agcaccgccg tcatacataa aaaaaggaaa taaggcgcac 3488161 cctccagaac ggcaaacagc ggtatttcaa actgagaaag ggagcccgcc agctccacca 3488221 acgtttcatt ataaacaaat gagatcacgc caaaaataag accgcttgcc acacttgcga 3488281 tttttgcttc tccgagccct ttcatctctt tcccaacaga ggataaaatc gcaacaactg 3488341 aaaggatgtt taaagaggta aacgtaatgc tcgcaggcca gttatactgc tgggacaaat 3488401 caatcgtcca cgtatggtga tgtgtgctct gaaaggagat cagcgcatat aaaagccccg 3488461 ctactaacac aggaatcaaa atactattta tagataatat tcctttcaca tcccacaaaa 3488521 acaagcacac tgtcacgatg caaatcagcg tgattcccca ccagaaagga agcttgtaca 3488581 tttgcagggt cacaccgcct ccggcaatca tcaccatagt cgtcgaaaac aaataaaaaa 3488641 tgatgaggac atcataaatt ttcgccagcc atggccccat taaatgctcc agaaccggca 3488701 gaaaatgagt ggattgaacc ttaaaactga ttttcatcac aatataagac gagaaaatga 3488761 acataattgt aaacagcaca atagcaagtc cgctttccgc cccaaaaaac tgccatatct 3488821 cctgaccgct cgcatatccg gccccgatca ggctccctaa tatgagcagc atccacttca 3488881 ttccggctct ccacaacact atcacctcat agacaaagtt cagcttgttc ccgttattgt 3488941 tactatataa ataaaggaaa gcaaacatgc catattttca tagacatttg aacacaagct 3489001 gaaattatca tacgaaatac acataaaaaa gactgctaat acggcagtct aaaaagagat 3489061 atttatttgt ttgtccgcgg aatgaagaag tgaacttcac tcttcacttt tttctaacca 3489121 ttcctaccta ttcaagtgtt tcataagcag accattgctt gatcatgatc gaggcaatgg 3489181 gggacaatac ttgtaatcgc ccactaacca ttcatatcat gccctctact tttttaaaat 3489241 ctctggtgcc atacacaaag cataaaaaat catactgctg gatatactgt aaacaacctt 3489301 acataactac acacaccata gcaattctgt tacctactat aacaaggaag tgaaacccat 3489361 gaatcgaaaa ggcgggcttt tttcttctca ggaacgagta aagcaatatg tttcacatac 3489421 agatgctgca gcggcaaaac aaatccaaac catcctttct tcatccttac gtaaagctgc 3489481 tggcaaacca attgtcgtgg tttgtatcgg aacagaccgt tcaaccggtg actcattagg 3489541 cccgctcgta ggaatgaaac tcaaacagat gcagctcacc agattccatg tctacggaac 3489601 cttatctgac cccgtccatg ctgtgaacat gaaggataaa atcaatgaca ttcataaatt 3489661 acataaaaac ccatttgtta tagcagtcga tgcatgctta ggccgcgtta agagtgtggg 3489721 ttcatttcaa atcggggacg ggccattaaa gcccggagcc ggtgtacaaa aagaccttcc 3489781 tgaagtggga gatcttcata ttaacggaat cgtgaatgtg agcggtttta tggaatattt 3489841 tgtattgcaa aatactagac tcaacttggt catgaatatg gcaaatgttc tagcggaagg 3489901 tttgagttta acagatcgga cagagtggag gcaagaacgc cttaacccgt tgcaaaggct 3489961 cactgggcgc atataaaata aaaaccatct tcgtttgaaa gatggttttt tcatttatga 3490021 ttctcgttca gacaaaagct ctaaaatccg gtcaaggtct tcattagaga aaaattcaat 3490081 ttcgattttg ccttttttct tctgtctttt aatattaact gttgttccaa aataattttg 3490141 gagataggat tcccgttctt ttagaaccgc atctttcaca ggttcttttt tctttgtttc 3490201 acgtggaaca ttctgattca actgctgaat cagctgctca agttggcgaa cattgagctg 3490261 ctccgcaatc actttttgta ccagcggttc aagcttattt ttgtttttta agccaagaag 3490321 cgtgcgtcca tgtcccatag aaagcgtgcc ttcggcaata agctgttgaa tattttctgg 3490381 cagtgtcagc agtcttaaat gattcgcaat atgcggtctg cttttcccaa gacgtttggc 3490441 aagctgctct tgtgtgagat ctaagtgttt caaaagggag tcatatgcct gagcctcttc 3490501 aagcggagat aaatcttcac gctgaaggtt ttctaataaa gcaatttccc tcattaacgc 3490561 ctctgataat tcacggacaa tggccggaac tgtatctaaa cctgccagct ttgccgctcg 3490621 aaaacgccgt tcacccgcaa caatatcata gccttttaaa gattttctga cgataagcgg 3490681 ctgaagaatg ccatgctgca gcacagattc ttttagttca gctaatgcct cgtcatcaaa 3490741 gtgttttctt ggctgataag gattagggcg taaatcggca attttaattt cttcaactgt 3490801 ctcttcagac aaatctacct gattaaataa cgcattaatc ccttttccaa ggcctttagc 3490861 cattcgcagc cacttccttt gctaaatcta aatatacttc cgcacctctt gaccgcggat 3490921 cgtataaaat gatgggtttt ccgtgactcg gtgcctcact cagacggaca ttacgcggaa 3490981 taactgtctt atatacttta tccctaaaat actttttaac ctcttcaatc acttgaatgc 3491041 caaggtttgt ccgggcatca agcattgtca gcaatacacc ttcaatcatt aaatcagtat 3491101 tcaaatgctt ttgcacaaga cgtactgtat ttaataactg gctgagaccc tccaaggcat 3491161 aatattcgca ctgtacagga atcacaacgg aatccgaggc agtaagggca ttaatcgtca 3491221 gcaagcccaa tgacggcgga caatcaatga taatataatc ataattttgc tttactgctt 3491281 caagcgctct cttcaatctc acttctcttg atattgtagg aaccagctcg atctcagccc 3491341 ctgcaagctg aatcgtcgca ggaatcacat ccaagttctc tactgtcgtt gctttaataa 3491401 tatctattac atctgcatca tctactaaaa tatcgtacac acactgctct acatcggctt 3491461 tttcaatccc taatccgctt gtcgcatttc cctgcggatc aatatctacc agcagaaccc 3491521 ttttccctat gtaagccaaa catgccccaa ggttgacaga cgtcgttgtt ttgccgaccc 3491581 cgcctttttg gttcgtaatt gctatgattt ttcccacgat gtcacctact ttcacatgaa 3491641 catgtactat cttgcttcta ttctatcaaa aaaagattaa agcgtttcat ttttttcatc 3491701 attttgttcc gaatcagaag ggaaataatt gaaaattcaa gcacgcttta tgctttctct 3491761 tataaattct gcaatttcta tgtttttttg acttaaaaaa ggaatttctt aaagaaaaaa 3491821 agaagaagtc acagtacaga acgtggaaac aggatggtga gaaaatggtt tatcaaacga 3491881 agagagatgt acccgttacg ctgatgattg tgtttctcat attactgata caagcagatg 3491941 ccattgttcc ttttgtgctg ggaaatatga gagtttccgg ctggatcatt tttattctgc 3492001 tgactctttt aaatggactc atcatttgga gctttattga cctaaaatat gtattgaagg 3492061 aacaccatct gatcattaaa gccggattga tcaaacatca aattccttat gaaaacatcg 3492121 ataaagtcgt tcaaaaaaag aaactatggt ccggttttcg tctgatcggc tctcgccatg 3492181 ccatcacaat atattatcag gggggatggg gacatgcagt aatttcaccg caaaaatctg 3492241 aagaatttat ccacaagctc aaagaaaaga attctaatat aataatattc actaaaagta 3492301 agtgattacc ttttgttaaa aatataaaaa gctctcctgc ttttcaggag agcttctatt 3492361 ttggtatgcg aatcgttaat tgaatatatt cttcaaattc ttcttcttcc gtattcaatt 3492421 ttacaccgct gtcttccacc attgatagtg actggcgaat cgtgttcatc gcaattcttg 3492481 tatctctgct gaatgctttg cgtctcggct ttggctttct ctggccttgc tccagcattt 3492541 tcaccacgcg gtcttctgtc tgctttacat ttaaactttt ctcaataatc tctgtgagca 3492601 gtgtgacttg gagctcaggc tgtttcagcg gaatcagtgc tctggcatgg cgctcggtga 3492661 ttttcttctc cataatcgcc tcttggaccg gctgaggcag ctttaataac cgaagcttat 3492721 tcgcgattgt agactgccct tttcctaagc gctgtgcgag tgcctcctgt gttaaatcat 3492781 gcagctcaag cagcctagca taagcatgcg cttcctcaat agaagacagt tcttcccgct 3492841 gcaagttttc gattaacgcc acagaagcgg tttccgtgtc ggaaaaatcc ttaataattg 3492901 ccggaatctt ttcccactca agcgattgca ccgctctcca gcgtctttca cctgcaatga 3492961 gttcgtattg gccttcttct tctgtatgcc taacaacaat cggctgaata atgccgtgtg 3493021 tatgaatggt cattgctaac tctttgattt tttcatctga gaaaatggtg cgtggctgaa 3493081 aacggttggg aacgatagca tttaccggta tttccagaat ctcttctttg tttgtatcat 3493141 gttcagcaat ctccggctcc tgttccttct caccaagccc gaagaaacga gagaatgaat 3493201 gcttcatgta cctacaccac ctttaaaaac tgccattttt ataattctat tttctcatgg 3493261 tttttcctgc tgtacatcca tcaattttga tgaaaatatg atggtattgt catatcaggc 3493321 tgtctaaatt acccttcaat tggcgattta ttaggagttc ccggttttct tggatacttc 3493381 ttaggtgtat tttttatttt gcgtatcacc ataatattac gatcgctttc ttcaataggc 3493441 agcttaaaag aatggatatt ctcaagttct cctccaagcg tcgtgattgc ttttttgcct 3493501 gcattcagtt cttcttcagc tgatgcggct tttaaagcaa caaataaacc gtttttcttc 3493561 accagaggca agcaaagctc actcaaaaca gataatctcg caactgcgcg cgccgtcaca 3493621 atatcatagc tttcacgcac gtctttccgt tgcccgaacg tttcagctct gtcatggcag 3493681 aatgttgtat tctccaattg caaagcttca gacaactttt ctaaaaacgt aatccgtttg 3493741 tttagtgaat ccacgattgt gacatggagg tgcggaaagc atatttttat cggcagactt 3493801 ggaaaacccg ctcccgctcc aacatcacaa atcgtgttca cctgattgaa gtcgacataa 3493861 aaagcagctg taatggaatc ataaaaatgc tttaaataca cttctttttt ctctgttatt 3493921 gaagtcagat tgattttttc gttccattca accagcatgt cgtaatacag ctcaaattgc 3493981 tccagctgac ggggagaaag ggagatccct ttttccgcca aaccagaagt gaattcttca 3494041 atattcatgc cgtcatcctt tctactcggc tatcttcgca atgcgtccct gctctaaata 3494101 caccaataga attgaaatgt ccgccgggtt tacaccggaa atgcgggaag cctgggcaac 3494161 agacaaaggc cgtacatttt tcagtttttg acgcgcctcg gtcgcaatcc ccttaattgc 3494221 gtcataatca attcggtctg gaattttttt attttccatc ttcttcagtt tttccacttg 3494281 ctgaagagat ttttcaatat atccttcata tttcacttgg atttctactt gttctgccac 3494341 gtcttgagga accggcactt ctggcggcgc cagttttgtg actgtttcat agttcatttc 3494401 aggacgtttc atcaagtctg tgccgcgaac tccatctttc aattcgcttc cgccaagaga 3494461 acggatatat tcttgatttt ccggagacgg cttgataatt acagaatgaa gacgtttttt 3494521 ctccgcctcg atcgccgctt ttttcttctc aaaagccgca tagcgctcat cagaaatcaa 3494581 tccaatgcga tgtccgattt ctgtcagacg caaatcagca ttgtcatggc gaagcagcaa 3494641 tctgtattcc gcacgtgatg tcaaaagacg atatggctca ttggtacctt ttgtcacaag 3494701 gtcatcaatc agaacaccaa tataggcgtc agaacggctt agaattactt cttcttttcc 3494761 aagcgctttt cgtcctgcat tgattcccgc cataatccct tgtcccgcag cttcttcata 3494821 accggatgtt ccgttaattt ggcctgcagt ataaaggttt gtgatttttt tggtttcaag 3494881 tgtcggccat agctgtgtcg gtacgattgc atcatactcg atcgcatagc cggctctcat 3494941 catttgcacg ttttcaagtc caggaatcgt tgcaagcatt ctttgctgta cgtcttctgg 3495001 aagacttgta gataaacctt ggacatagac ttcctgtgta tttctgcctt ccggctcaag 3495061 gaagatttgg tgacgcggtt tatcattaaa acggacaact ttgtcttcaa tggatgggca 3495121 gtatcttggg cccgtacctt tgatcatacc ggaatacatc ggtgaacggt gcaggttgct 3495181 gtcaataatc tcatgtgtct cagggcttgt atatgtcagc cagcaaggga gctgatctgt 3495241 gatatattcc actgtttcat atgagaaagc gcgaggcaca tcgtcaccag gctgaatttc 3495301 cgttttgctg taatcaatcg tgtcgctttt aacgcgaggc ggcgtacctg ttttaaaacg 3495361 aacaaggtca aaaccgagtt cctccaaatg ctcagaaagc ttaatagaag gctgctggtt 3495421 attcgggccg cttgagtaag acagatcgcc aagaatgata cgtcctctta aatatgtccc 3495481 tgtcgtcatg acaactgctt tcgcacgata atgtgcgcct gtttgtgtaa taacgcctcg 3495541 gcattcgccg tcttcaacga tcagccgctc cacaattcct tgcagcaatg ttaagtttgg 3495601 ttctttttca agcgtatttt tcatttcgtg ctgatattgg aatttgtctg cttgcgcacg 3495661 caatgcacga accgcaggac cttttcctgt attcagcatt ctcatttgaa tatgtgtttt 3495721 atcgatgttt cttcccattt ctccgccgag cgcgtcaatt tcgcggacga caatcccttt 3495781 tgcggggccg ccgacagacg gattacatgg cataaatgca accatatcta ggttgatggt 3495841 caagacaagc gttttggcgc cttggcgtgc agatgcgagg gcagcctcaa caccggcatg 3495901 cccggcgcca atcacaatca catcgtattg gcctgcttca taccccatga ttctagttcc 3495961 tcctttaatt attttcctaa acagaattga gaaaagagct gatcaattaa gctttcgtgg 3496021 acagaatctc caatgatttc ccctaaaagc tcccagcatc ttgtaaggtc aatttgcacc 3496081 atgtcgatcg ggacatcctg ttcgatgccg ctaagcgcat cttcaatggc gcgttttgct 3496141 tgctgtaaaa tagtgatgtg acgtgtgttg ctgacataag tcagatcacc gctttcaatg 3496201 gcacccgtgt agaacagtga ttgaatcgct tcttccagat cattgatgcc ttcctctttt 3496261 aaaagagatg tcgtaacaac tggacgtcca ttggcaagct cacggacacg ttcagtgtca 3496321 atcttcggct caaggtcagt cttattcaaa atcacgataa catccatgcc ctcaacggct 3496381 tcaaaaagct tcacgtcttc ttcagaaagc tcttcactat aattaagcac aagtaaaatc 3496441 aggtccgctt cctttaggac ctggcgagaa cgttcaacac cgattcgctc aacaatatcc 3496501 tctgtttcac gaatacctgc tgtatcaacc agacgaagcg gaacgcccct tacattcacg 3496561 tattcctcaa tcacatcccg tgtcgttccg ggaatatcgg ttacaatggc ttttgcctca 3496621 tgaacgaggc tgttcagaag agatgatttt cctacgtttg gccggccgat aatgacggta 3496681 gaaagacctt cacgcaagat ttttccttgc tcagaagtcc tcagcagcgt ctcaatttcc 3496741 tttttcacgg cggttgcctt ttcgactaaa atctgatgcg tcatttcctc tacatcatca 3496801 tactccggat aatcaatatt cacctcaaca tgggccagtg tttctaaaat ctcactgcgc 3496861 aaacggcgca ccaaagcaga aagacgccct tccatttgat tcatagcaac gttcattgcc 3496921 cggtccgttt tcgctctgat taagtccata accgcttccg cctgtgaaag atcgattcgg 3496981 ccgtttaaaa acgcacgttt cgtaaattca ccaggctctg ccagtctcgc tccctctctc 3497041 aatgcaagct gaagcacttg gttcacagtc acaattcccc cgtgacagtt aatctcgatg 3497101 acatcttctc gtgtaaaagt tctcggcgct tttaacactg ataccattac ttcctcaacg 3497161 acacgatccg aaggtctgtc tacgatatga ccataatgaa tcgtatgtga ttcgaccgag 3497221 ctgagtgttt tccccttcgg tcccttataa attttatctg cgatttgaat ggcttctggt 3497281 ccgctcaacc gtacaatcgc aatcgcgcct tctcccatcg gtgtggaaat tgccgcaatt 3497341 gtatccatgt tgttcacctc tctttactta tacttcatct atataaaaaa atttttatta 3497401 tgccaaaact aaaagataac atagtttggt tcgaagtgga agatttgtta tccacagaaa 3497461 tagaaattcg tcccttatta ctttaactta tccacatgtg aataacaatt aattttattt 3497521 cctgaacttc ctttttatca acaggataca cctaaaaaga aaaaacttaa acggcaaaac 3497581 cttgatatta ctaggaaaag tagatttttc ggatacaaaa aaaccgaaat ccaattttta 3497641 tcggacttcg gttttatgct atcttttatg ggaaataacg agatgacgat tttcgccttc 3497701 acccattgaa tatgttttga tctggtggtt tgcatatcca gaaagagtat cgtgaataat 3497761 ttttctttcg ctggacggca tgggctcaag ctggatggat tttttcgttt tcaaaacctg 3497821 gtcagcaagc ttgatggcca gctggctcag tgtttctttt cttttcaaac gatagttttc 3497881 tgcatccacc gtcacatttt tatattggcc tggataacgg ttaagggcaa gctgtgtcaa 3497941 agtttcaagg gcgtttaaag tttgtcctct tttcccaatc aacaatgctg ccttttcacc 3498001 tgttatatga tatctcactg tctttttgct ttcttgaaca gtcacatcag acttcccggc 3498061 aatggcttcg gcaatcgttt gaagatataa cttcgcttgc tgaatcggat caatcttttc 3498121 aaccagcttt acgatcgcag gctttttacc gaaaataccg agaaaccctt tgtttccctc 3498181 ttcaataaca gtaatttcta ccttatcctt cgttaatccc aactcttgca atccggactg 3498241 tactgcttca tcgacatttc gccctgcagc agtcacattc ctcacttttt ctttcctccg 3498301 gctttttgcg gctcaggatt ttttttaata tcaggtcctt taatgaggaa agtttgcgca 3498361 atcataaaca agttaccaac tacccaataa agagaaagag ccgccgggaa gttgatcgca 3498421 aatacgataa tcataattgg cataatccaa agcatcatcg ccatttgcgg attttgctgc 3498481 gcattgccag ccatcatcag tttttgctga acaaatgtag cgacaccggc aacgatagga 3498541 agaatatagt aaggatcttt ttctcctaag tcaaaccata agaagctatg ctctgaaatc 3498601 gcctgggttc tcatgatcgc atgatagaat ccaattaaaa tcggcatctg gatcaaaatc 3498661 gggaaacatc ccgccaatgg attgacacca tgcttttgga ataaagccat tgtttcctgt 3498721 tgaagctttt gctgcgtttt ttgatccttt gagctgtatt tttctttaag cttttgcatt 3498781 tccggctgta aagcctgcat cgctttcgaa cttctcagct gcttaatcat cagcggtaaa 3498841 attaataaac gaattaaaat ggtaactaga ataattgaaa gcccgtagtt atctcccgtc 3498901 aatttcgcta catacgtaat gagctcagac aatggatata ctacgtactt gtcccagaaa 3498961 tgcggactat ctgcagtgat cggctctttc acactcgagc atccagccaa aagcatgaat 3499021 acgccaacca tacttaatag caaccctatt ctccttttca acaacatttc ctcctataat 3499081 taatctttac actcttttat tgcaaagcat acttgtatgt attttagcat ctttcagttt 3499141 taaatggtgt ctttttctga tcaaccagaa aggaagcgct tttaaaagtt gtaagaaagc 3499201 agtggtgatg cctactttga cgaagatttc ttatataatg aagactttct gaatagatgc 3499261 tgcagacttt ttttcgtttc ctcatatgtc agctggctcg ccggttttct ggcaataatg 3499321 atgtaatcct tttccttcag tctctctttc tcttcaagaa aggcctgccg aatcaaacgt 3499381 ttgatccgat ttcgcatcac agcattgcca atttttttgc tgacggaaag cccgacacgc 3499441 agttcatcat tttcaggctg atcaagcgta tataagacaa actggcggtt tgcaactgat 3499501 gtcccatgtt taaacacttt ttgaaaatct tcatttttct ttaaacgatt tcgcttcttc 3499561 aaatgactca ctccgatact ggctggcaga aacttttaaa atttattatg aacatgagat 3499621 gcatctgaac caggaagcat gccccggttc attacgcatc acatctatct tttcccataa 3499681 cgtgaaaaaa gaccactgac attattcagt ggcctaagct gataatactt ttctgccttt 3499741 gcggcgacgg cgtgctaaaa ctagacgacc gttttttgaa ctcatacggc ttctgaagcc 3499801 atgaactttg ctgcgtttac ggttattcgg ttggaatgtt cttttcattt atgacacctc 3499861 cctcgaggaa tagctgttaa agacagtctt acttattata tttgcgttac ctattcattg 3499921 tcaacttcac tagtgctttt atttcttgca accataatag gataccatac cttttcaact 3499981 ttcgaaacct tattttttag attccttaat tttacggaaa aaagacaaat tcaaacaatt 3500041 tgcccctaaa atcacgcatg tggatatctt tttcggcttt ttttagtatc cacagaggtt 3500101 atcgacaaca ttttcacatt accaacccct gtggacaagg ttttttcaac aggttgtccg 3500161 ctttgtggat aagattgtga caaccattgc aagctctcgt ttattttggt attatatttg 3500221 tgttttaact cttgattact aatcctacct ttcctcttta tccacaaagt gtggataagt 3500281 tgtggattga tttcacacag cttgtgtaga aggttgtcca caagttgtga aatttgtcga 3500341 aaagctattt atctactata ttatatgttt tcaacattta atgtgtacga atggtaagcg 3500401 ccatttgctc tttttttgtg ttctataaca gagaaagacg ccattttcta agaaaaggag 3500461 ggacgtgccg gaag //